{ "directed": true, "multigraph": false, "graph": {}, "nodes": [ { "id": "reaction_10509451", "map_id": "none", "name": "Release of Cytochrome c from mitochondria", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10567341", "map_id": "none", "name": "(DOCK7)", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10567330", "map_id": "none", "name": "HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "G5EDJ4", "map_id": "G5EDJ4", "name": "phospho-soc-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004928", "map_id": "WBGene00004928", "name": "phospho-soc-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XVQ7", "map_id": "Q9XVQ7", "name": "MET", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008711", "map_id": "WBGene00008711", "name": "MET", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P29355", "map_id": "P29355", "name": "sem-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004774", "map_id": "WBGene00004774", "name": "sem-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9NHC3", "map_id": "Q9NHC3", "name": "ced-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000416", "map_id": "WBGene00000416", "name": "ced-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q95XA9", "map_id": "Q95XA9", "name": "gap-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021238", "map_id": "WBGene00021238", "name": "gap-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10567343", "map_id": "none", "name": "HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:(DOCK7)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10567332", "map_id": "none", "name": "GAB1 recruits CRK,CRKL to MET", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. 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For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10520269", "map_id": "none", "name": "CRK, CRKL", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10543879", "map_id": "none", "name": "HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10567348", "map_id": "none", "name": "DOCK7 activates RAC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29438", "map_id": "CHEBI:15996", "name": "GTP", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10541992", "map_id": "none", "name": "RAC1:GDP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_29420", "map_id": "CHEBI:17552", "name": "GDP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "Q03206", "map_id": "Q03206", "name": "ced-10", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ced-10", "map_id": "ced-10", "name": "ced-10", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10509457", "map_id": "none", "name": "RAC1:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10567336", "map_id": "none", "name": "RAPGEF1 binds CRK,CRKL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10528529", "map_id": "H2KZX7", "name": "RAPGEF1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00021320", "map_id": "WBGene00021320", "name": "RAPGEF1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10567334", "map_id": "none", "name": "HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:RAPGEF1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "H2KZX7", "map_id": "H2KZX7", "name": "RAPGEF1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10567339", "map_id": "none", "name": "RAPGEF1 activates RAP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10518265", "map_id": "none", "name": "RAP1:GDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q18246", "map_id": "Q18246", "name": "rap-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004307", "map_id": "WBGene00004307", "name": "rap-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10518164", "map_id": "none", "name": "RAP1:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10502772", "map_id": "none", "name": "Inactivation of Cyclin E:Cdk2 complexes by p27/p21", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10502767", "map_id": "G5EEJ2", "name": "cki-2", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00000517", "map_id": "WBGene00000517", "name": "phospho-cki-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10502749", "map_id": "none", "name": "CCNE:CDK2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "O61847", "map_id": "O61847", "name": "cdk-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019362", "map_id": "WBGene00019362", "name": "cdk-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10502769", "map_id": "none", "name": "Cyclin E:CDK2:CDKN1A,CDKN1B", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "G5EEJ2", "map_id": "G5EEJ2", "name": "phospho-cki-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10517476", "map_id": "none", "name": "Autoubiquitination of phospho-COP1(Ser-387 )", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10517469", "map_id": "Q965F9", "name": "phospho-par-2", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00003917", "map_id": "WBGene00003917", "name": "par-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10502375", "map_id": "none", "name": "Ub", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P49632", "map_id": "P49632", "name": "ubq-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006728", "map_id": "WBGene00006728", "name": "ubq-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P37165", "map_id": "P37165", "name": "ubl-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006725", "map_id": "WBGene00006725", "name": "ubl-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P0CG71", "map_id": "P0CG71", "name": "ubq-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006727", "map_id": "WBGene00006727", "name": "ubq-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10517473", "map_id": "none", "name": "ubiquitinated phospho-COP1(ser-387)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q965F9", "map_id": "Q965F9", "name": "par-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10517478", "map_id": "none", "name": "Proteasome mediated degradation of COP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10502572", "map_id": "none", "name": "26S proteasome", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P91477", "map_id": "P91477", "name": "pbs-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003950", "map_id": "WBGene00003950", "name": "pbs-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q95PZ7", "map_id": "Q95PZ7", "name": "PSME3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": 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"inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q20058", "map_id": "Q20058", "name": "PSMD5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009445", "map_id": "WBGene00009445", "name": "PSMD5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9N599", "map_id": "Q9N599", "name": "pas-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003924", "map_id": "WBGene00003924", "name": "pas-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O16368", "map_id": "O16368", "name": "rpt-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004502", "map_id": "WBGene00004502", "name": "rpt-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O61742", "map_id": "O61742", "name": "rpn-10", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004466", "map_id": "WBGene00004466", "name": "rpn-10", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q09583", "map_id": "Q09583", "name": "pas-7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003928", "map_id": "WBGene00003928", "name": "pas-7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q966I8", "map_id": "Q966I8", "name": "pbs-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003947", "map_id": "WBGene00003947", "name": "pbs-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q04908", "map_id": "Q04908", "name": "rpn-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004460", "map_id": "WBGene00004460", "name": "rpn-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XUV0", "map_id": "Q9XUV0", "name": "pbs-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003951", "map_id": "WBGene00003951", "name": "pbs-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q27488", "map_id": "Q27488", "name": "pas-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003923", "map_id": "WBGene00003923", "name": "pas-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9GZH5", "map_id": "Q9GZH5", "name": "rpn-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004458", "map_id": "WBGene00004458", "name": "rpn-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O44156", "map_id": "O44156", "name": "pas-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003927", "map_id": "WBGene00003927", "name": "pas-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q22253", "map_id": "Q22253", "name": "rpn-9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004465", "map_id": "WBGene00004465", "name": "rpn-9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O76577", "map_id": "O76577", "name": "rpn-11", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004467", "map_id": "WBGene00004467", "name": "rpn-11", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P90868", "map_id": "P90868", "name": "pbs-7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003953", "map_id": "WBGene00003953", "name": "pbs-7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q19324", "map_id": "Q19324", "name": "rpn-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004461", "map_id": "WBGene00004461", "name": "rpn-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q17971", "map_id": "Q17971", "name": "PSME4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007588", "map_id": "WBGene00007588", "name": "PSME4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q23237", "map_id": "Q23237", "name": "pbs-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003949", "map_id": "WBGene00003949", "name": "pbs-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q20938", "map_id": "Q20938", "name": "rpn-6.1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004462", "map_id": "WBGene00004462", "name": "rpn-6.1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10517471", "map_id": "none", "name": "Translocation of COP1 from the nucleus to the cytoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13231", "compartment_display": "nuclear envelope" }, { "id": "species_10517467", "map_id": "Q965F9", "name": "phospho-par-2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10512670", "map_id": "none", "name": "Inactivation of Cyclin A:Cdk2 complexes by p27/p21", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10511613", "map_id": "none", "name": "CCNA:CDK2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10512663", "map_id": "none", "name": "Cyclin A:Cdk2:p21/p27 complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10552354", "map_id": "none", "name": "GGTs hydrolyse glutamate from AFXBO-SG, AFNBO-SG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_5490253", "map_id": "none", "name": "AFXBO-SG,AFNBO-SG", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "CHEBI:78581", "map_id": "CHEBI:78581", "name": "CHEBI:78581", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:78587", "map_id": "CHEBI:78587", "name": "CHEBI:78587", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_109276", "map_id": "CHEBI:15377", "name": "H2O", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_210382", "map_id": "CHEBI:29985", "name": "L-Glu", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_5490235", "map_id": "none", "name": "AFXBO-CG,AFNBO-CG", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "CHEBI:78579", "map_id": "CHEBI:78579", "name": "CHEBI:78579", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:78584", "map_id": "CHEBI:78584", "name": "CHEBI:78584", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10552351", "map_id": "none", "name": "GGT dimers", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "H2L0B7", "map_id": "H2L0B7", "name": "GGT5(1-387)", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020590", "map_id": "WBGene00020590", "name": "GGT5(1-387)", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O18256", "map_id": "O18256", "name": "GGT5(1-387)", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9N5V4", "map_id": "Q9N5V4", "name": "GGT5(1-387)", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A486WVP7", "map_id": "A0A486WVP7", "name": "GGT5(1-387)", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "B5BM47", "map_id": "B5BM47", "name": "GGT5(1-387)", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10552364", "map_id": "none", "name": "ACY1:Zn2+ dimer hydrolyses mercapturic acids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5490236", "map_id": "none", "name": "AFXBO-NAC,AFNBO-NAC", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:78580", "map_id": "CHEBI:78580", "name": "CHEBI:78580", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:78585", "map_id": "CHEBI:78585", "name": "CHEBI:78585", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_29356", "map_id": "CHEBI:15377", "name": "H2O", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_2022890", "map_id": "CHEBI:15366", "name": "CH3COO-", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_5490231", "map_id": "none", "name": "AFXBO-C,AFNBO-C", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:78583", "map_id": "CHEBI:78583", "name": "CHEBI:78583", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:78578", "map_id": "CHEBI:78578", "name": "CHEBI:78578", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10552361", "map_id": "none", "name": "ACY1:Zn2+ dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_216785", "map_id": "CHEBI:29105", "name": "Zn2+", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "Q5WRS4", "map_id": "Q5WRS4", "name": "ACY1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00015509", "map_id": "WBGene00015509", "name": "ACY1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10525168", "map_id": "none", "name": "Synthesis of dolichyl-phosphate-glucose", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_449299", "map_id": "CHEBI:16214", "name": "DOLP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_453087", "compartment_display": "integral component of cytoplasmic side of endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_29410", "map_id": "CHEBI:18066", "name": "UDP-Glc", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_532214", "map_id": "CHEBI:15812", "name": "DbGP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_453087", "compartment_display": "integral component of cytoplasmic side of endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_110096", "map_id": "CHEBI:17659", "name": "UDP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10525165", "map_id": "Q8WSL9", "name": "algn-5", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "WBGene00019276", "map_id": "WBGene00019276", "name": "algn-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10563798", "map_id": "none", "name": "NUDT14 hydrolyses UDP-Glc to G1P and UMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29548", "map_id": "CHEBI:16077", "name": "G1P", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_109402", "map_id": "CHEBI:16695", "name": "UMP", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10563795", "map_id": "Q95ZW9", "name": "NUDT14", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00008238", "map_id": "WBGene00008238", "name": "NUDT14", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10529329", "map_id": "none", "name": "SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10529324", "map_id": "none", "name": "SMG1:UPF1:EJC:Translated mRNP", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P91914", "map_id": "P91914", "name": "rpl-27", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004441", "map_id": "WBGene00004441", "name": "rpl-27", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q19869", "map_id": "Q19869", "name": "rpl-26", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", 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For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10529305", "map_id": "none", "name": "Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q09543", "map_id": "Q09543", "name": "paa-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003901", "map_id": "WBGene00003901", "name": "paa-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EDR3", "map_id": "G5EDR3", "name": "sur-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006352", "map_id": "WBGene00006352", "name": "sur-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EGK8", "map_id": "G5EGK8", "name": "let-92", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002363", "map_id": "WBGene00002363", "name": "let-92", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9BL68", "map_id": "Q9BL68", "name": "smg-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004884", "map_id": "WBGene00004884", "name": "smg-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10529290", "map_id": "none", "name": "mRNA Cleaved by SMG6", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10572480", "map_id": "none", "name": "Misfolded proteins bind PRKN:UBE2N:UBE2V1:Ub", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10572476", "map_id": "none", "name": "Ub:UBE2N:UBE2V1:PRKN", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q95XX0", "map_id": "Q95XX0", "name": "ubc-13", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006708", "map_id": "WBGene00006708", "name": "ubc-13", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O45495", "map_id": "O45495", "name": "uev-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006730", "map_id": "WBGene00006730", "name": "uev-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10572472", "map_id": "none", "name": "Misfolded Proteins", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "G5ED37", "map_id": "G5ED37", "name": "osm-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003885", "map_id": "WBGene00003885", "name": "osm-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "H2L0N8", "map_id": "H2L0N8", "name": "arl-13", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021349", "map_id": "WBGene00021349", "name": "arl-13", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P30644", "map_id": "P30644", "name": "Misfolded CETN1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011145", "map_id": "WBGene00011145", "name": "Misfolded CETN1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P90994", "map_id": "P90994", "name": "djr-1.1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00015184", "map_id": "WBGene00015184", "name": "djr-1.1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10572478", "map_id": "none", "name": "Misfolded proteins:PRKN:UBE2N:UBE2V1:Ub", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10572551", "map_id": "none", "name": "PolyUb-Misfolded Proteins:HDAC6 bind dynein motor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10572547", "map_id": "none", "name": "PolyUb-Misfolded Proteins:HDAC6", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q19625", "map_id": "Q19625", "name": "mrp-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003412", "map_id": "WBGene00003412", "name": "mrp-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q95QV2", "map_id": "Q95QV2", "name": "cft-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000477", "map_id": "WBGene00000477", "name": "cft-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q20296", "map_id": "Q20296", "name": "hda-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018319", "map_id": "WBGene00018319", "name": "hda-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10552960", "map_id": "none", "name": "Dynein complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q19020", "map_id": "Q19020", "name": "dhc-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000962", "map_id": "WBGene00000962", "name": "dhc-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O45087", "map_id": "O45087", "name": "dyci-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00015927", "map_id": "WBGene00015927", "name": "dyci-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q65XS9", "map_id": "Q65XS9", "name": "dlc-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00043067", "map_id": "WBGene00043067", "name": "dlc-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0AAC1", "map_id": "A0AAC1", "name": "dlc-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012424", "map_id": "WBGene00012424", "name": "dlc-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7YTJ8", "map_id": "Q7YTJ8", "name": "dlc-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012425", "map_id": "WBGene00012425", "name": "dlc-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q21557", "map_id": "Q21557", "name": "dlc-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010888", "map_id": "WBGene00010888", "name": "dlc-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q22799", "map_id": "Q22799", "name": "dlc-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001005", "map_id": "WBGene00001005", "name": "dlc-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5ED34", "map_id": "G5ED34", "name": "dli-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001007", "map_id": "WBGene00001007", "name": "dli-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10572549", "map_id": "none", "name": "PolyUb-Misfolded Proteins:HDAC6:Dynein complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10572520", "map_id": "none", "name": "Parkin transfers Ub to misfolded proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10572518", "map_id": "none", "name": "Ub:Misfolded proteins:PRKN:UBE2N:UBE2V1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10572522", "map_id": "none", "name": "Ub:misfolded proteins polymerize to PolyUb:misfolded proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10572500", "map_id": "none", "name": "PolyUb:Misfolded proteins:PRKN:UBE2N:UBE2V1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10550384", "map_id": "none", "name": "p62 links damaged mitochondria to LC3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10550378", "map_id": "Q23536", "name": "lgg-2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00002981", "map_id": "WBGene00002981", "name": "lgg-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10550373", "map_id": "none", "name": "K48polyUB Mitophagy Substrates:SQSTM1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "true" }, { "id": "Q23424", "map_id": "Q23424", "name": "fzo-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001509", "map_id": "WBGene00001509", "name": "fzo-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q17746", "map_id": "Q17746", "name": "SQSTM1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00015552", "map_id": "WBGene00015552", "name": "SQSTM1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q18746", "map_id": "Q18746", "name": "K48polyUb-MTERFD1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008236", "map_id": "WBGene00008236", "name": "K48polyUb-MTERFD1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q21752", "map_id": "Q21752", "name": "vdac-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019900", "map_id": "WBGene00019900", "name": "vdac-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10550382", "map_id": "none", "name": "LC3:K48polyUB Mitophagy Substrates:SQSTM1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q23536", "map_id": "Q23536", "name": "lgg-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10550417", "map_id": "none", "name": "Pink1 is cleaved on healthy mitochondria", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space" }, { "id": "species_10550393", "map_id": "Q09298", "name": "pink-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "false" }, { "id": "WBGene00017137", "map_id": "WBGene00017137", "name": "pink-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10550415", "map_id": "Q09298", "name": "pink-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "false" }, { "id": "reaction_10550409", "map_id": "none", "name": "LC3 binds the autophagosome membrane Atg5-Atg12 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_21994", "compartment_display": "phagocytic vesicle" }, { "id": "species_10550405", "map_id": "none", "name": "ATG5:ATG12", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_1222693", "compartment_display": "phagocytic vesicle membrane", "complex": "true" }, { "id": "Q3V5I7", "map_id": "Q3V5I7", "name": "atg-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022152", "map_id": "WBGene00022152", "name": "atg-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q10931", "map_id": "Q10931", "name": "lgg-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002982", "map_id": "WBGene00002982", "name": "lgg-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10550407", "map_id": "none", "name": "ATG5:ATG12:LC3:K48polyUB Mitophagy Substrates:SQSTM1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_21994", "compartment_display": "phagocytic vesicle", "complex": "true" }, { "id": "reaction_10550411", "map_id": "none", "name": "Uncleaved Pink1 accumulates in damaged mitochondria", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane" }, { "id": "species_10550389", "map_id": "Q09298", "name": "pink-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "false" }, { "id": "reaction_10550413", "map_id": "none", "name": "p62 binds ubiquitinated mitochondrial substrates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10550366", "map_id": "Q21752", "name": "vdac-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "false" }, { "id": "species_10550360", "map_id": "Q18746", "name": "K48polyUb-MTERFD1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "false" }, { "id": "species_10550371", "map_id": "Q17746", "name": "SQSTM1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10550354", "map_id": "Q23424", "name": "fzo-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "false" }, { "id": "species_10550352", "map_id": "Q23424", "name": "fzo-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "false" }, { "id": "reaction_10568834", "map_id": "none", "name": "FUNDC1 is phosphorylated by ULK1 at Ser17", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane" }, { "id": "species_10568806", "map_id": "Q22252", "name": "fndc-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "false" }, { "id": "WBGene00011528", "map_id": "WBGene00011528", "name": "phospho-fndc-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10568831", "map_id": "Q22252", "name": "phospho-fndc-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "false" }, { "id": "species_10568813", "map_id": "Q23023", "name": "unc-51", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "false" }, { "id": "WBGene00006786", "map_id": "WBGene00006786", "name": "unc-51", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10570165", "map_id": "none", "name": "Phosphorylated FUNDC1 links damaged mitochondria to LC3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10570159", "map_id": "none", "name": "p-S17-FUNDC1:LC3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "true" }, { "id": "Q22252", "map_id": "Q22252", "name": "phospho-fndc-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10568823", "map_id": "none", "name": "p-S13-FUNDC1 is dephosphorylated by PGAM5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10568809", "map_id": "Q22252", "name": "phospho-fndc-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "false" }, { "id": "species_10568820", "map_id": "Q09422", "name": "pgam-5", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "false" }, { "id": "WBGene00019941", "map_id": "WBGene00019941", "name": "pgam-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10568811", "map_id": "none", "name": "FUNDC1 is phosphorylated by CK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10515097", "map_id": "none", "name": "Casein kinase II", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P18334", "map_id": "P18334", "name": "kin-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002191", "map_id": "WBGene00002191", "name": "kin-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P28548", "map_id": "P28548", "name": "kin-10", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002196", "map_id": "WBGene00002196", "name": "kin-10", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10568828", "map_id": "none", "name": "p-S13, FUNDC1 is phosphorylated by CK2 at Tyr18", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10568826", "map_id": "Q22252", "name": "phospho-fndc-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "false" }, { "id": "species_10513079", "map_id": "none", "name": "Homologues of SRC-2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "G5EE56", "map_id": "G5EE56", "name": "src-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00005077", "map_id": "WBGene00005077", "name": "src-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9N3S5", "map_id": "Q9N3S5", "name": "LCK", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021635", "map_id": "WBGene00021635", "name": "LCK", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10568815", "map_id": "none", "name": "ULK1 Translocates to the mitochondria", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane" }, { "id": "species_10554651", "map_id": "Q23023", "name": "unc-51", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10527767", "map_id": "none", "name": "Binding of acetylcholine to highly sodium permeable postsynaptic acetylcholine receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10527685", "map_id": "none", "name": "Highly sodium permeable nicotinic acetylcholine receptors", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "G5EDF1", "map_id": "G5EDF1", "name": "acr-12", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000051", "map_id": "WBGene00000051", "name": "acr-12", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q93329", "map_id": "Q93329", "name": "lev-8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002975", "map_id": "WBGene00002975", "name": "lev-8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O17274", "map_id": "O17274", "name": "lgc-34", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020836", "map_id": "WBGene00020836", "name": "lgc-34", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9N4M3", "map_id": "Q9N4M3", "name": "acr-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000045", "map_id": "WBGene00000045", "name": "acr-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P48181", "map_id": "P48181", "name": "unc-29", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006765", "map_id": "WBGene00006765", "name": "unc-29", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9N587", "map_id": "Q9N587", "name": "unc-63", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006797", "map_id": "WBGene00006797", "name": "unc-63", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P48182", "map_id": "P48182", "name": "acr-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000042", "map_id": "WBGene00000042", "name": "acr-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q23022", "map_id": "Q23022", "name": "unc-38", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006774", "map_id": "WBGene00006774", "name": "unc-38", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q23355", "map_id": "Q23355", "name": "acr-8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000047", "map_id": "WBGene00000047", "name": "acr-8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q27218", "map_id": "Q27218", "name": "lev-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002974", "map_id": "WBGene00002974", "name": "lev-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q93149", "map_id": "Q93149", "name": "acr-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000043", "map_id": "WBGene00000043", "name": "acr-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "H2KZY7", "map_id": "H2KZY7", "name": "lgc-27", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022283", "map_id": "WBGene00022283", "name": "lgc-27", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_372533", "map_id": "CHEBI:15355", "name": "AcCho", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10527687", "map_id": "none", "name": "O-Acetylcholine bound to Acetylcholine receptor", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10527690", "map_id": "none", "name": "Activation of highly sodium permeable postsynaptic nicotinic acetylcholine receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_74113", "map_id": "CHEBI:29101", "name": "Na+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_83910", "map_id": "CHEBI:29101", "name": "Na+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10564113", "map_id": "none", "name": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_6810408", "map_id": "CHEBI:16500", "name": "PI5P", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_29358", "map_id": "CHEBI:30616", "name": "ATP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_113582", "map_id": "CHEBI:456216", "name": "ADP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_6810412", "map_id": "CHEBI:18348", "name": "PI(4,5)P2", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10564110", "map_id": "none", "name": "PIP4K2 dimers", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9BL73", "map_id": "Q9BL73", "name": "ppk-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004088", "map_id": "WBGene00004088", "name": "ppk-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10563787", "map_id": "none", "name": "TMEM55B translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_172574", "compartment_display": "late endosome membrane" }, { "id": "species_10563783", "map_id": "Q9BL29", "name": "TMEM55B", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_172574", "compartment_display": "late endosome membrane", "complex": "false" }, { "id": "WBGene00022167", "map_id": "WBGene00022167", "name": "TMEM55B", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10563785", "map_id": "Q9BL29", "name": "TMEM55B", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10563790", "map_id": "none", "name": "PI(4,5)P2 is dephosphorylated to PI5P by TMEM55B in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_113518", "map_id": "CHEBI:15377", "name": "H2O", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_113550", "map_id": "CHEBI:43474", "name": "Pi", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10511490", "map_id": "none", "name": "Ral-GDS binds to Ras-GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10511486", "map_id": "Q19852", "name": "rgl-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00017891", "map_id": "WBGene00017891", "name": "rgl-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10511481", "map_id": "none", "name": "p21 RAS:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "P22981", "map_id": "P22981", "name": "let-60", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002335", "map_id": "WBGene00002335", "name": "let-60", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10511488", "map_id": "none", "name": "Ras-GTP:RalGDS complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q19852", "map_id": "Q19852", "name": "rgl-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10512661", "map_id": "none", "name": "p38 MAPK phosphorylates MAPKAPK2, MAPKAPK3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10512628", "map_id": "none", "name": "MAPKAP kinase", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q21360", "map_id": "Q21360", "name": "phospho-mak-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010681", "map_id": "WBGene00010681", "name": "phospho-mak-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q965G5", "map_id": "Q965G5", "name": "phospho-mak-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007007", "map_id": "WBGene00007007", "name": "phospho-mak-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10512646", "map_id": "none", "name": "p-S272,T222,T334-MAPKAPK2, p-S,2T-MAPKAPK3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10512658", "map_id": "none", "name": "Phospho-MAP kinase p38 (Mg2+ cofactor)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q17446", "map_id": "Q17446", "name": "phospho-pmk-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004055", "map_id": "WBGene00004055", "name": "phospho-pmk-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8MXI4", "map_id": "Q8MXI4", "name": "phospho-pmk-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004056", "map_id": "WBGene00004056", "name": "phospho-pmk-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_114632", "map_id": "CHEBI:18420", "name": "Mg2+", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "reaction_10572080", "map_id": "none", "name": "p-T,Y MAPK dimers translocate to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10542082", "map_id": "none", "name": "p-T,Y MAPK dimers", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P39745", "map_id": "P39745", "name": "phospho-mpk-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003401", "map_id": "WBGene00003401", "name": "phospho-mpk-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10514067", "map_id": "none", "name": "p-T,Y MAPK dimers", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10572066", "map_id": "none", "name": "Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_74700", "compartment_display": "endosome membrane" }, { "id": "species_10572055", "map_id": "none", "name": "RAP1:GTP:activated BRAF dimer:MAPK2K:MAPK complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "true" }, { "id": "Q10664", "map_id": "Q10664", "name": "phospho-mek-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003186", "map_id": "WBGene00003186", "name": "phospho-mek-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P41932", "map_id": "P41932", "name": "par-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003920", "map_id": "WBGene00003920", "name": "par-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q20655", "map_id": "Q20655", "name": "ftt-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001502", "map_id": "WBGene00001502", "name": "ftt-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q07292", "map_id": "Q07292", "name": "lin-45", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003030", "map_id": "WBGene00003030", "name": "lin-45", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10572059", "map_id": "none", "name": "RAP1:GTP:activated BRAF dimer:p-2S MAPK2K:MAPK complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "true" }, { "id": "reaction_10572070", "map_id": "none", "name": "Dissociation of phosphorylated MAP2Ks and MAPKs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10572068", "map_id": "none", "name": "RAP1:GTP:activated BRAF dimer:p-2S MAPK2K:p-T,Y MAPK complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "true" }, { "id": "species_10555065", "map_id": "none", "name": "p-2S MAP2K homo/heterodimers", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10508583", "map_id": "P39745", "name": "phospho-mpk-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10572053", "map_id": "none", "name": "RAP1:GTP:activated BRAF dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "true" }, { "id": "reaction_10572057", "map_id": "none", "name": "Activated BRAF recruits MAP2Ks and MAPKs to the endosome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_74700", "compartment_display": "endosome membrane" }, { "id": "species_10508575", "map_id": "P39745", "name": "mpk-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10555040", "map_id": "none", "name": "MAP2K homo/heterodimers", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10572073", "map_id": "none", "name": "MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10555163", "map_id": "none", "name": "p-T,Y MAPKs dimerize", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10572078", "map_id": "none", "name": "BRAF autophosphorylates downstream of RAP1 and NGF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_74700", "compartment_display": "endosome membrane" }, { "id": "species_10572075", "map_id": "none", "name": "RAP1:GTP:B-Raf complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "true" }, { "id": "reaction_10572117", "map_id": "none", "name": "SGK phosphorylates SRF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10572112", "map_id": "Q18955", "name": "unc-120", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00006844", "map_id": "WBGene00006844", "name": "phospho-unc-120", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10572115", "map_id": "Q18955", "name": "phospho-unc-120", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10572104", "map_id": "Q2PJ68", "name": "phospho-sgk-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00004789", "map_id": "WBGene00004789", "name": "sgk-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10572132", "map_id": "none", "name": "NAB2 and CHD4 bind and repress EGR-mediated RRAD gene expression", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10572122", "map_id": "Q22002", "name": "mab-10", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00003107", "map_id": "WBGene00003107", "name": "mab-10", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10547994", "map_id": "none", "name": "Homologues of CHD4", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "G5EBZ4", "map_id": "G5EBZ4", "name": "let-418", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002637", "map_id": "WBGene00002637", "name": "let-418", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q22516", "map_id": "Q22516", "name": "chd-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000482", "map_id": "WBGene00000482", "name": "chd-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10572128", "map_id": "none", "name": "RRAD gene:EGR2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q18250", "map_id": "Q18250", "name": "egrh-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007772", "map_id": "WBGene00007772", "name": "egrh-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10572130", "map_id": "none", "name": "RRAD gene:EGR2:NAB2:CHD4", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q22002", "map_id": "Q22002", "name": "mab-10", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10572107", "map_id": "none", "name": "SGK phosphorylates CREB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10514243", "map_id": "D0Z5N1", "name": "crh-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00000793", "map_id": "WBGene00000793", "name": "phospho-crh-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10514246", "map_id": "D0Z5N1", "name": "phospho-crh-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10514065", "map_id": "none", "name": "ERK1/2/5 activate RSK1/2/3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10514008", "map_id": "none", "name": "Ribosomal protein S6 kinase", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q19858", "map_id": "Q19858", "name": "RPS6KA3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017898", "map_id": "WBGene00017898", "name": "RPS6KA3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q21734", "map_id": "Q21734", "name": "rskn-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011352", "map_id": "WBGene00011352", "name": "rskn-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10514054", "map_id": "none", "name": "Phospho-Ribosomal protein S6 kinase", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10514062", "map_id": "none", "name": "p-MAPK3/MAPK1/MAPK7 dimers", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "H2KYF8", "map_id": "H2KYF8", "name": "mpk-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003402", "map_id": "WBGene00003402", "name": "mpk-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10514435", "map_id": "none", "name": "ERKs are inactivated by protein phosphatase 2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10514418", "map_id": "none", "name": "MAPK3/MAPK1/MAPK7 dimers", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10514432", "map_id": "none", "name": "PP2A-ABdeltaC complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "A9UJN4", "map_id": "A9UJN4", "name": "pptr-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007554", "map_id": "WBGene00007554", "name": "pptr-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10514070", "map_id": "none", "name": "ERK1/2 phosphorylates MSK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10513966", "map_id": "Q18846", "name": "rskn-2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00008311", "map_id": "WBGene00008311", "name": "rskn-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10513972", "map_id": "Q18846", "name": "phospho-rskn-2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10513975", "map_id": "none", "name": "p38MAPK phosphorylates MSK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10510865", "map_id": "none", "name": "p-p38 MAPK alpha/beta", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10515399", "map_id": "none", "name": "ERKs are inactivated by dual-specific phosphatases (DUSPs)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10515396", "map_id": "none", "name": "ERK-specific DUSP", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9XUJ0", "map_id": "Q9XUJ0", "name": "DUSP7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012372", "map_id": "WBGene00012372", "name": "DUSP7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10514385", "map_id": "none", "name": "RSK1/2/3 phosphorylates CREB at Serine 133", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10514402", "map_id": "none", "name": "MAPKAPK2 phosphorylates CREB at Serine 133", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10514399", "map_id": "none", "name": "Homologues of p-T222,S272-MAPKAPK2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10514404", "map_id": "none", "name": "MSK1 activates CREB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10514393", "map_id": "none", "name": "MSK1 activates ATF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10514387", "map_id": "D0Z5N1", "name": "crh-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10514390", "map_id": "D0Z5N1", "name": "phospho-crh-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10513986", "map_id": "none", "name": "ERK5 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10513982", "map_id": "H2KYF8", "name": "phospho-mpk-2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10513984", "map_id": "H2KYF8", "name": "phospho-mpk-2", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10515269", "map_id": "none", "name": "PIP3 binds to RhoA and activates it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10509484", "map_id": "Q22038", "name": "rho-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "WBGene00004357", "map_id": "WBGene00004357", "name": "rho-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_179838", "map_id": "CHEBI:16618", "name": "PI(3,4,5)P3", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10515267", "map_id": "none", "name": "PIP3:RhoA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q22038", "map_id": "Q22038", "name": "rho-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10545459", "map_id": "none", "name": "Syndecans 1, 2, 4, (3) bind FGF2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10512869", "map_id": "Q11184", "name": "let-756", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "WBGene00002881", "map_id": "WBGene00002881", "name": "let-756", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10541682", "map_id": "P50605", "name": "sdn-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "WBGene00004749", "map_id": "WBGene00004749", "name": "phospho-sdn-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10545457", "map_id": "none", "name": "SDC1,2,4,(3):FGF2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "P50605", "map_id": "P50605", "name": "phospho-sdn-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q11184", "map_id": "Q11184", "name": "let-756", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10545556", "map_id": "none", "name": "Syndecan-1 binds Integrins alpha2beta1, (alpha6beta4)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10545552", "map_id": "none", "name": "Integrin alpha2beta1, (alpha6beta4)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "P34446", "map_id": "P34446", "name": "pat-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003929", "map_id": "WBGene00003929", "name": "pat-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q27874", "map_id": "Q27874", "name": "pat-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003930", "map_id": "WBGene00003930", "name": "pat-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10545554", "map_id": "none", "name": "Syndecan-1:Integrin alpha2beta1 (alpha6beta4)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10545560", "map_id": "none", "name": "Syndecans 2, (4) bind TGFB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10511429", "map_id": "none", "name": "Homologues of TGFB1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "G5EBY8", "map_id": "G5EBY8", "name": "unc-129", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006852", "map_id": "WBGene00006852", "name": "unc-129", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EEL5", "map_id": "G5EEL5", "name": "dbl-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000936", "map_id": "WBGene00000936", "name": "dbl-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10541684", "map_id": "P50605", "name": "sdn-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10545558", "map_id": "none", "name": "Syndecans 2, (4):TGFB1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10545913", "map_id": "none", "name": "Syndecan-4:PI(4,5)P2 binds PKC alpha:DAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10545909", "map_id": "none", "name": "Syndecan-4:PI(4,5)P2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_179856", "map_id": "CHEBI:18348", "name": "PI(4,5)P2", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10521475", "map_id": "none", "name": "Protein Kinase C, alpha type: DAG", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "P90980", "map_id": "P90980", "name": "pkc-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004033", "map_id": "WBGene00004033", "name": "pkc-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_114519", "map_id": "CHEBI:17815", "name": "DAG", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10545911", "map_id": "none", "name": "Syndecan-4:PI(4,5)P2:Protein kinase C, alpha type:DAG", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10545564", "map_id": "none", "name": "Syndecan-1 binds fibronectin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10517394", "map_id": "none", "name": "Fibronectin matrix", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "Q18705", "map_id": "Q18705", "name": "phospho-p-FN1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016769", "map_id": "WBGene00016769", "name": "phospho-p-FN1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q18914", "map_id": "Q18914", "name": "phospho-ensh-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017013", "map_id": "WBGene00017013", "name": "phospho-ensh-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XXE9", "map_id": "Q9XXE9", "name": "phospho-p-FN1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10545562", "map_id": "none", "name": "Syndecan-1:Fibronectin matrix", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10546406", "map_id": "none", "name": "DHX9 binds DNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_3134861", "map_id": "none", "name": "Unmethylated CpG DNA", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10546400", "map_id": "Q22307", "name": "rha-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00004355", "map_id": "WBGene00004355", "name": "rha-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10546402", "map_id": "none", "name": "DHX9:CpG", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q22307", "map_id": "Q22307", "name": "rha-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10546408", "map_id": "none", "name": "DHX36 binds DNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10546396", "map_id": "Q20644", "name": "DHX36", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00009922", "map_id": "WBGene00009922", "name": "DHX36", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10546398", "map_id": "none", "name": "DHX36:CpG", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q20644", "map_id": "Q20644", "name": "DHX36", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10527102", "map_id": "none", "name": "GRIK3 homomer binds glutamate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10526044", "map_id": "none", "name": "GRIK 3 homomer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "A0A1T5HUM0", "map_id": "A0A1T5HUM0", "name": "glr-7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001618", "map_id": "WBGene00001618", "name": "glr-7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O01623", "map_id": "O01623", "name": "glr-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001616", "map_id": "WBGene00001616", "name": "glr-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q17697", "map_id": "Q17697", "name": "glr-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001615", "map_id": "WBGene00001615", "name": "glr-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_2730999", "map_id": "CHEBI:17996", "name": "Cl-", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_10527100", "map_id": "none", "name": "GRIK3 homomer glutamate complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_113552", "map_id": "CHEBI:29985", "name": "L-Glu", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "reaction_10526120", "map_id": "none", "name": "Edited Kainate Receptor binds glutamate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10526116", "map_id": "none", "name": "Edited Kainate receptors", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10526118", "map_id": "none", "name": "Edited Kainate Receptor-glutamate complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10526123", "map_id": "none", "name": "Activation of Edited Kainate receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "reaction_10526080", "map_id": "none", "name": "kainate receptor binds glutamate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10526076", "map_id": "none", "name": "Kainate Receptors", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "G5ECY0", "map_id": "G5ECY0", "name": "dlg-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001006", "map_id": "WBGene00001006", "name": "dlg-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q22638", "map_id": "Q22638", "name": "mics-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011890", "map_id": "WBGene00011890", "name": "mics-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P36609", "map_id": "P36609", "name": "ncs-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003564", "map_id": "WBGene00003564", "name": "ncs-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q11083", "map_id": "Q11083", "name": "CALM1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020378", "map_id": "WBGene00020378", "name": "CALM1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P04630", "map_id": "P04630", "name": "cal-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000285", "map_id": "WBGene00000285", "name": "cal-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EF37", "map_id": "G5EF37", "name": "pat-10", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003934", "map_id": "WBGene00003934", "name": "pat-10", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A2C9C3L3", "map_id": "A0A2C9C3L3", "name": "CALM1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q18136", "map_id": "Q18136", "name": "cal-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006861", "map_id": "WBGene00006861", "name": "cal-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q09665", "map_id": "Q09665", "name": "tnc-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006583", "map_id": "WBGene00006583", "name": "tnc-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O02159", "map_id": "O02159", "name": "CALM1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EDZ8", "map_id": "G5EDZ8", "name": "cal-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000288", "map_id": "WBGene00000288", "name": "cal-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q94288", "map_id": "Q94288", "name": "cal-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000287", "map_id": "WBGene00000287", "name": "cal-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q09980", "map_id": "Q09980", "name": "cal-8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017394", "map_id": "WBGene00017394", "name": "cal-8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O16305", "map_id": "O16305", "name": "cmd-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000552", "map_id": "WBGene00000552", "name": "cmd-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EEG0", "map_id": "G5EEG0", "name": "cal-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000286", "map_id": "WBGene00000286", "name": "cal-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10526078", "map_id": "none", "name": "Kainate receptor-glutamate complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10526126", "map_id": "none", "name": "Activation of Ca-permeable Kainate receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_74112", "map_id": "CHEBI:29108", "name": "Ca2+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_74016", "map_id": "CHEBI:29108", "name": "Ca2+", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "reaction_10526193", "map_id": "none", "name": "arginine + H2O => ornithine + urea [ARG2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_374064", "map_id": "CHEBI:32682", "name": "L-Arg", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_113521", "map_id": "CHEBI:15377", "name": "H2O", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_374061", "map_id": "CHEBI:16199", "name": "Urea", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_113585", "map_id": "CHEBI:15729", "name": "L-Orn", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10526190", "map_id": "none", "name": "ARG2 trimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "species_266099", "map_id": "CHEBI:29035", "name": "Mn2+", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "A0A1X7RC97", "map_id": "A0A1X7RC97", "name": "argn-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020658", "map_id": "WBGene00020658", "name": "argn-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10503273", "map_id": "none", "name": "ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_113567", "map_id": "CHEBI:16349", "name": "L-Cit", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_29498", "map_id": "CHEBI:15729", "name": "L-Orn", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_29968", "map_id": "CHEBI:16349", "name": "L-Cit", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10503270", "map_id": "Q10050", "name": "SLC25A15", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "WBGene00020422", "map_id": "WBGene00020422", "name": "SLC25A15", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10503167", "map_id": "none", "name": "arginine + H2O => ornithine + urea [ARG1]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29468", "map_id": "CHEBI:32682", "name": "L-Arg", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_29514", "map_id": "CHEBI:16199", "name": "Urea", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10503164", "map_id": "none", "name": "ARG1 trimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10525558", "map_id": "none", "name": "Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10525555", "map_id": "none", "name": "p38 MAPK:MAPKAPK2,3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10525449", "map_id": "none", "name": "p-p38 MAPK: MAPKAPK2,3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10525533", "map_id": "none", "name": "p-S189,T193-MAP2K3, p-S207,T211-MAP2K6", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "G5EDF7", "map_id": "G5EDF7", "name": "phospho-sek-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004758", "map_id": "WBGene00004758", "name": "phospho-sek-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q58AU7", "map_id": "Q58AU7", "name": "phospho-sek-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018034", "map_id": "WBGene00018034", "name": "phospho-sek-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q58AU8", "map_id": "Q58AU8", "name": "phospho-sek-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018035", "map_id": "WBGene00018035", "name": "phospho-sek-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10525464", "map_id": "none", "name": "Active p38 MAPK phosphorylates MAPKAPK2 or 3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10525461", "map_id": "none", "name": "p-p38 MAPK:p-MAPKAPK2/3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10525468", "map_id": "none", "name": "Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10525466", "map_id": "none", "name": "p-p38 MAPK: p-S272,T222,T334-MAPKAPK2, p-S,2T-MAPKAPK3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10525535", "map_id": "none", "name": "Phosphorylated MKK3/MKK6 migrates to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10525521", "map_id": "none", "name": "p-S189,T193-MAP2K3, p-S207,T211-MAP2K6", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10525578", "map_id": "none", "name": "Activated human JNKs migrate to nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10510969", "map_id": "none", "name": "p-MAPK8,9,10", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q8WQG9", "map_id": "Q8WQG9", "name": "jnk-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002178", "map_id": "WBGene00002178", "name": "jnk-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "H2KZI0", "map_id": "H2KZI0", "name": "kgb-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002188", "map_id": "WBGene00002188", "name": "kgb-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O44408", "map_id": "O44408", "name": "kgb-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002187", "map_id": "WBGene00002187", "name": "kgb-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10510908", "map_id": "none", "name": "p-MAPK8,9,10", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10510988", "map_id": "none", "name": "Phosphorylation of human JNKs by activated MKK4/MKK7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10510949", "map_id": "none", "name": "MAPK8,9,10", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10510985", "map_id": "none", "name": "p-MAP2K4/p-MAP2K7", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q21307", "map_id": "Q21307", "name": "phospho-mek-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003185", "map_id": "WBGene00003185", "name": "phospho-mek-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q20347", "map_id": "Q20347", "name": "phospho-mkk-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003368", "map_id": "WBGene00003368", "name": "phospho-mkk-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10510992", "map_id": "none", "name": "Formation of Activated Protein 1 (AP-1) complex. ATF2/c-JUN heterodimer. ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10510926", "map_id": "G5ECU7", "name": "phospho-jun-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00012005", "map_id": "WBGene00012005", "name": "phospho-jun-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10510845", "map_id": "Q86MD3", "name": "phospho-atf-7", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00000223", "map_id": "WBGene00000223", "name": "atf-7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10510990", "map_id": "none", "name": "p-2S-cJUN:p-2T-ATF2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q86MD3", "map_id": "Q86MD3", "name": "atf-7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5ECU7", "map_id": "G5ECU7", "name": "phospho-jun-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10510929", "map_id": "none", "name": "Activated JNKs phosphorylate c-JUN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10510922", "map_id": "G5ECU7", "name": "jun-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10525492", "map_id": "none", "name": "Formation of Activated Protein 1 (AP-1) complex. cFOS/c-JUN heterodimer. ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10525488", "map_id": "none", "name": "Homologues of p-T325,T331,S362,S374-FOS", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "G5ECG2", "map_id": "G5ECG2", "name": "phospho-fos-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001345", "map_id": "WBGene00001345", "name": "phospho-fos-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9N5A8", "map_id": "Q9N5A8", "name": "phospho-zip-11", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021082", "map_id": "WBGene00021082", "name": "phospho-zip-11", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10525490", "map_id": "none", "name": "p-2S-cJUN:p-2S,2T-cFOS", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10510917", "map_id": "none", "name": "Phosphorylated MAPKs phosphorylate ATF-2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10510841", "map_id": "Q86MD3", "name": "atf-7", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10510914", "map_id": "none", "name": "Activated MAPK kinases ERK1/2, JNK, p38", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10525543", "map_id": "none", "name": "c-FOS activation by phospho ERK1/2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10525541", "map_id": "none", "name": "Homologues of FOS", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10528549", "map_id": "none", "name": "Translocation of p-STAT1:p-STAT1 dimer to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13231", "compartment_display": "nuclear envelope" }, { "id": "species_10528455", "map_id": "none", "name": "p-Y701-STAT1-1 dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10528543", "map_id": "none", "name": "p-Y701-STAT1 dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10528547", "map_id": "none", "name": "p-STAT1 dimer:KPNA1:KPNB1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q22560", "map_id": "Q22560", "name": "ima-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002072", "map_id": "WBGene00002072", "name": "ima-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9BIB8", "map_id": "Q9BIB8", "name": "imb-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002075", "map_id": "WBGene00002075", "name": "imb-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10537425", "map_id": "none", "name": "ISGylation of protein translation regulator 4EHP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10537411", "map_id": "Q22888", "name": "ife-4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00002062", "map_id": "WBGene00002062", "name": "ife-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10531955", "map_id": "none", "name": "ISG15:UBCH8:ISG15 E3 ligase", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9BL11", "map_id": "Q9BL11", "name": "herc-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021685", "map_id": "WBGene00021685", "name": "herc-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O01965", "map_id": "O01965", "name": "ari-1.1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016158", "map_id": "WBGene00016158", "name": "ari-1.1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P91057", "map_id": "P91057", "name": "ISG15", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00015842", "map_id": "WBGene00015842", "name": "ISG15", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q21633", "map_id": "Q21633", "name": "ubc-18", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006713", "map_id": "WBGene00006713", "name": "ubc-18", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10537413", "map_id": "none", "name": "ISGylated 4EHP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q22888", "map_id": "Q22888", "name": "ife-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10531986", "map_id": "none", "name": "Transfer of ISG15 from E1 to E2 (UBCH8)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10529367", "map_id": "Q21633", "name": "ubc-18", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10531957", "map_id": "none", "name": "ISG15:UBA7", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q27481", "map_id": "Q27481", "name": "uba-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006699", "map_id": "WBGene00006699", "name": "uba-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10529372", "map_id": "Q27481", "name": "uba-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10531946", "map_id": "none", "name": "ISG15:UBCH8", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10531971", "map_id": "none", "name": "ISGylation of host protein filamin B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10531966", "map_id": "none", "name": "Homologues of FLNB", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "D0VWL6", "map_id": "D0VWL6", "name": "phospho-fln-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016006", "map_id": "WBGene00016006", "name": "phospho-fln-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "U4PBJ9", "map_id": "U4PBJ9", "name": "phospho-fln-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022048", "map_id": "WBGene00022048", "name": "phospho-fln-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_111294", "map_id": "CHEBI:29888", "name": "PPi", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10531953", "map_id": "none", "name": "ISG15 E3 ligases", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_76577", "map_id": "CHEBI:16027", "name": "AMP", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10531968", "map_id": "none", "name": "ISGylated Filamin B", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10531975", "map_id": "none", "name": "Interaction of ISG15 with NEDD4 and inhibition of Ebola virus budding", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10530876", "map_id": "A0A061ACQ8", "name": "NEDD4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00022358", "map_id": "WBGene00022358", "name": "NEDD4L", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10529362", "map_id": "P91057", "name": "ISG15", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10531973", "map_id": "none", "name": "ISG15:NEDD4", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "A0A061ACQ8", "map_id": "A0A061ACQ8", "name": "NEDD4L", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10531960", "map_id": "none", "name": "Activation of ISG15 by UBA7 E1 ligase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10531992", "map_id": "none", "name": "ISGylation of protein phosphatase 1 beta (PP2CB)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10531988", "map_id": "Q19775", "name": "ppm-1.A", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00006460", "map_id": "WBGene00006460", "name": "ppm-1.A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10531990", "map_id": "none", "name": "ISGylated PP2CB", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q19775", "map_id": "Q19775", "name": "ppm-1.A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10532011", "map_id": "none", "name": "ISGylation of host proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10532007", "map_id": "none", "name": "ISG15 targets", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "H8W3X5", "map_id": "H8W3X5", "name": "UBE2E3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00219376", "map_id": "WBGene00219376", "name": "UBE2E3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q22070", "map_id": "Q22070", "name": "plc-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004038", "map_id": "WBGene00004038", "name": "plc-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10532009", "map_id": "none", "name": "ISGylated host proteins", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10531981", "map_id": "none", "name": "ISGylation of E2 conjugating enzymes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10531977", "map_id": "none", "name": "E2 congugating enzymes", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10531979", "map_id": "none", "name": "ISGylated E2 conjugating enzymes", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10537406", "map_id": "none", "name": "Regulation of protein ISGylation by ISG15 deconjugating enzyme USP18", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_141681", "map_id": "none", "name": "polypeptide", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10537403", "map_id": "none", "name": "USP18-like proteins", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "H2L010", "map_id": "H2L010", "name": "USP18", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020695", "map_id": "WBGene00020695", "name": "USP18", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10531983", "map_id": "none", "name": "Interaction of E3 ligase with ISG15:E2 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10537423", "map_id": "none", "name": "Competitive inhibition of translation initiation by ISGylated 4EHP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10537419", "map_id": "none", "name": "eIF4F:mRNA", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q20935", "map_id": "Q20935", "name": "EIF4A1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018997", "map_id": "WBGene00018997", "name": "EIF4A1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P27639", "map_id": "P27639", "name": "inf-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002083", "map_id": "WBGene00002083", "name": "inf-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O61955", "map_id": "O61955", "name": "ife-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002061", "map_id": "WBGene00002061", "name": "ife-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10537421", "map_id": "none", "name": "ISGylated 4EHP:mRNA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10537417", "map_id": "none", "name": "EIF4F", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10570813", "map_id": "none", "name": "PDE12 cleaves 2'-5' oligoadenylates ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_8983696", "map_id": "none", "name": "2'-5' oligoadenylate", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_70106", "map_id": "CHEBI:15378", "name": "H+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10570810", "map_id": "O18005", "name": "pde-12", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00011268", "map_id": "WBGene00011268", "name": "pde-12", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10528100", "map_id": "none", "name": "PIAS1 binds p-STAT1 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10528077", "map_id": "none", "name": "IFNG-activated factor (GAF)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10528091", "map_id": "none", "name": "Homologues of PIAS1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q21970", "map_id": "Q21970", "name": "miz-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011259", "map_id": "WBGene00011259", "name": "miz-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q94361", "map_id": "Q94361", "name": "gei-17", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001574", "map_id": "WBGene00001574", "name": "gei-17", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10528096", "map_id": "P55853", "name": "smo-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00004888", "map_id": "WBGene00004888", "name": "smo-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10528098", "map_id": "none", "name": "p-STAT1 dimer:PIAS:SUMO1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "P55853", "map_id": "P55853", "name": "smo-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10528079", "map_id": "none", "name": "Translocation of STAT1 dimer to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13231", "compartment_display": "nuclear envelope" }, { "id": "species_10528069", "map_id": "none", "name": "IFNG-activated factor (GAF)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10554345", "map_id": "none", "name": "FGFRL1 dimer binds FGFs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10554341", "map_id": "none", "name": "FGFRL1-binding FGFs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "G5EEF1", "map_id": "G5EEF1", "name": "egl-17", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001185", "map_id": "WBGene00001185", "name": "egl-17", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10554339", "map_id": "none", "name": "FGFRL1 dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q95XJ7", "map_id": "Q95XJ7", "name": "igcm-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022418", "map_id": "WBGene00022418", "name": "igcm-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_190915", "map_id": "CHEBI:28815", "name": "HS", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10554343", "map_id": "none", "name": "FGFRL1-binding FGFs:FGFRL1 dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10554354", "map_id": "none", "name": "KAL1 binds HS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10554350", "map_id": "G5EDX1", "name": "kal-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "WBGene00002181", "map_id": "WBGene00002181", "name": "kal-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10554352", "map_id": "none", "name": "KAL1:HS", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "G5EDX1", "map_id": "G5EDX1", "name": "kal-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10554370", "map_id": "none", "name": "FGFR1-associated PI3K phosphorylates PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10543825", "map_id": "none", "name": "Activated FGFR1:p-FRS2:GRB2:GAB1:PI3K", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q94125", "map_id": "Q94125", "name": "age-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000090", "map_id": "WBGene00000090", "name": "age-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EDP9", "map_id": "G5EDP9", "name": "aap-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000001", "map_id": "WBGene00000001", "name": "aap-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "E6N0V1", "map_id": "E6N0V1", "name": "phospho-rog-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018819", "map_id": "WBGene00018819", "name": "phospho-rog-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10512173", "map_id": "none", "name": "Binding of PIK3 regulatory alpha subunit to GRB2:GAB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10512121", "map_id": "none", "name": "GRB2:GAB1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10506883", "map_id": "G5EDP9", "name": "aap-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10512171", "map_id": "none", "name": "GRB2:GAB1:PIK3R1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10554373", "map_id": "none", "name": "FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10543855", "map_id": "none", "name": "Activated FGFR2:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10554358", "map_id": "none", "name": "Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10506890", "map_id": "Q94125", "name": "age-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10543831", "map_id": "none", "name": "Activated FGFR2:p-FRS2:GRB2:GAB1:PIK3R1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10543833", "map_id": "none", "name": "Activated FGFR2:p-FRS2:GRB2:GAB1:PI3K", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10554376", "map_id": "none", "name": "FGFR2-associated PI3K phosphorylates PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10554365", "map_id": "none", "name": "Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10512175", "map_id": "none", "name": "p21 RAS:GDP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10554362", "map_id": "none", "name": "Activated FGFR2:p-FRS:GRB2:SOS1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9N5D3", "map_id": "Q9N5D3", "name": "sos-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004947", "map_id": "WBGene00004947", "name": "sos-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10562965", "map_id": "none", "name": "PTB and hnRNPA1 bind FGFR2 pre-mRNA to repress IIIb splicing and promote formation of FGFR2c mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10504458", "map_id": "Q18999", "name": "ptb-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00004207", "map_id": "WBGene00004207", "name": "ptb-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10504465", "map_id": "P34541", "name": "HNRNPA1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00019881", "map_id": "WBGene00019881", "name": "HNRNPA1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10562961", "map_id": "none", "name": "capped, methylated pre-FGFR2 mRNA:CBC complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q8MYM8", "map_id": "Q8MYM8", "name": "gtf-2f2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012694", "map_id": "WBGene00012694", "name": "gtf-2f2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q17558", "map_id": "Q17558", "name": "gtf-2f1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00015296", "map_id": "WBGene00015296", "name": "gtf-2f1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q17684", "map_id": "Q17684", "name": "rpb-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007355", "map_id": "WBGene00007355", "name": "rpb-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q19826", "map_id": "Q19826", "name": "rpb-8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017830", "map_id": "WBGene00017830", "name": "rpb-8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O02092", "map_id": "O02092", "name": "rpb-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018391", "map_id": "WBGene00018391", "name": "rpb-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XVH6", "map_id": "Q9XVH6", "name": "rpb-11", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012187", "map_id": "WBGene00012187", "name": "rpb-11", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9GR61", "map_id": "Q9GR61", "name": "rpb-10", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021347", "map_id": "WBGene00021347", "name": "rpb-10", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9U3I0", "map_id": "Q9U3I0", "name": "rpb-12", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009078", "map_id": "WBGene00009078", "name": "rpb-12", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9N3C9", "map_id": "Q9N3C9", "name": "rpb-7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021845", "map_id": "WBGene00021845", "name": "rpb-7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q965S0", "map_id": "Q965S0", "name": "rpb-9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022400", "map_id": "WBGene00022400", "name": "rpb-9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P16356", "map_id": "P16356", "name": "phospho-ama-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000123", "map_id": "WBGene00000123", "name": "phospho-ama-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9N5K2", "map_id": "Q9N5K2", "name": "rpb-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019246", "map_id": "WBGene00019246", "name": "rpb-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q93338", "map_id": "Q93338", "name": "rpb-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007971", "map_id": "WBGene00007971", "name": "rpb-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q10578", "map_id": "Q10578", "name": "rpb-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016140", "map_id": "WBGene00016140", "name": "rpb-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10562963", "map_id": "none", "name": "FGFR2 IIIc-specific splicing complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "P34541", "map_id": "P34541", "name": "HNRNPA1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q18999", "map_id": "Q18999", "name": "ptb-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10554385", "map_id": "none", "name": "FGFR4-associated PI3K phosphorylates PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10543849", "map_id": "none", "name": "Activated FGFR4:p-FRS2:GRB2:GAB1:PI3K", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10554332", "map_id": "none", "name": "Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10554329", "map_id": "none", "name": "Activated FGFR3:p-FRS:GRB2:SOS1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10554379", "map_id": "none", "name": "FGFR3-associated PI3K phosphorylates PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10543841", "map_id": "none", "name": "Activated FGFR3:p-FRS2:GRB2:GAB1:PI3K", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10554367", "map_id": "none", "name": "Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10543839", "map_id": "none", "name": "Activated FGFR3:p-FRS2:GRB2:GAB1:PIK3R1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10554382", "map_id": "none", "name": "FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10543861", "map_id": "none", "name": "Activated FGFR3:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10546375", "map_id": "none", "name": "Beta-catenin migrates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10546373", "map_id": "O44326", "name": "phospho-hmp-2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00001979", "map_id": "WBGene00001979", "name": "hmp-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10546371", "map_id": "O44326", "name": "phospho-hmp-2", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10536514", "map_id": "none", "name": "Excess homocysteine yields homolanthionine and H2S", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_174369", "map_id": "CHEBI:17230", "name": "HCYS", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_1614532", "map_id": "CHEBI:16136", "name": "H2S", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_1614594", "map_id": "CHEBI:62856", "name": "HLAN", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10536511", "map_id": "none", "name": "PXLP-K212-CTH tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P55216", "map_id": "P55216", "name": "cth-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022856", "map_id": "WBGene00022856", "name": "cth-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10571811", "map_id": "none", "name": "MPST transfers sulfur atom from 3MPYR to form CysS248-MPST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_9012592", "map_id": "CHEBI:16208", "name": "3MPYR", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10570931", "map_id": "G5ECA0", "name": "mpst-6", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "WBGene00022006", "map_id": "WBGene00022006", "name": "mpst-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_113557", "map_id": "CHEBI:15361", "name": "PYR", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10571809", "map_id": "G5ECA0", "name": "mpst-6", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10571815", "map_id": "none", "name": "TXN2 binds CysS248-MPST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10547396", "map_id": "Q17424", "name": "trx-2", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "WBGene00007099", "map_id": "WBGene00007099", "name": "trx-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10571813", "map_id": "none", "name": "CysS248-MPST:TXN2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "G5ECA0", "map_id": "G5ECA0", "name": "mpst-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q17424", "map_id": "Q17424", "name": "trx-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10536520", "map_id": "none", "name": "Excess cysteine yields lanthionine and H2S", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_111707", "map_id": "CHEBI:35235", "name": "L-Cys", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_1614582", "map_id": "CHEBI:21347", "name": "L-Lanthionine", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10571817", "map_id": "none", "name": "CysS248-MPST:TXN2 dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10547399", "map_id": "Q17424", "name": "trx-2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_1655881", "map_id": "CHEBI:16136", "name": "H2S", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10536553", "map_id": "none", "name": "CDO1:Fe2+ oxidises L-Cys to 3-Sulfinoalanine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29368", "map_id": "CHEBI:15379", "name": "O2", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_1614519", "map_id": "CHEBI:16345", "name": "3-Sulfinoalanine", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10536550", "map_id": "none", "name": "CDO1:Fe2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q20893", "map_id": "Q20893", "name": "cdo-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018986", "map_id": "WBGene00018986", "name": "cdo-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_113531", "map_id": "CHEBI:29033", "name": "Fe2+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10536501", "map_id": "none", "name": "Sulfite is oxidized to sulfate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_113533", "map_id": "CHEBI:15379", "name": "O2", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_1614538", "map_id": "CHEBI:17359", "name": "sulfite(2-)", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_1614617", "map_id": "CHEBI:16240", "name": "H2O2", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_1614584", "map_id": "CHEBI:16189", "name": "SO4(2-)", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10536498", "map_id": "none", "name": "holo-SUOX", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q9XTQ8", "map_id": "Q9XTQ8", "name": "suox-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010397", "map_id": "WBGene00010397", "name": "suox-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_947539", "map_id": "CHEBI:25372", "name": "MoCo", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10536503", "map_id": "none", "name": "Sulfate is exported to the cytosol in exchange for dicarboxylate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane" }, { "id": "species_198498", "map_id": "CHEBI:30797", "name": "MAL", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_113544", "map_id": "CHEBI:30797", "name": "MAL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_174375", "map_id": "CHEBI:16189", "name": "SO4(2-)", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10518419", "map_id": "G5EE96", "name": "slc-25a10", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "WBGene00019656", "map_id": "WBGene00019656", "name": "slc-25a10", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10536538", "map_id": "none", "name": "Persulfide sulfur is dioxygenated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane" }, { "id": "species_10536526", "map_id": "O62133", "name": "sqrd-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "WBGene00008538", "map_id": "WBGene00008538", "name": "sqrd-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_113529", "map_id": "CHEBI:15378", "name": "H+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10536528", "map_id": "O62133", "name": "sqrd-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "species_10536535", "map_id": "none", "name": "ETHE1:2Zn2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "O17636", "map_id": "O17636", "name": "ethe-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007886", "map_id": "WBGene00007886", "name": "ethe-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10571219", "map_id": "none", "name": "MPST transfers sulfur from 3MPYR to HCN to form HSCN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_9013199", "map_id": "CHEBI:18407", "name": "HCN", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_9013191", "map_id": "CHEBI:29200", "name": "HSCN", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10571186", "map_id": "none", "name": "TST transfers sulfur from S2O3(2-) to HCN to form HSCN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_1614595", "map_id": "CHEBI:16094", "name": "S2O3(2-)", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_9013207", "map_id": "CHEBI:17359", "name": "SO3(2-)", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10571183", "map_id": "none", "name": "Homologues of TST", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "O17730", "map_id": "O17730", "name": "mpst-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008409", "map_id": "WBGene00008409", "name": "mpst-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EEV0", "map_id": "G5EEV0", "name": "mpst-7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011307", "map_id": "WBGene00011307", "name": "mpst-7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P91247", "map_id": "P91247", "name": "mpst-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017387", "map_id": "WBGene00017387", "name": "mpst-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XTX2", "map_id": "Q9XTX2", "name": "mpst-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010380", "map_id": "WBGene00010380", "name": "mpst-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "H9G340", "map_id": "H9G340", "name": "mpst-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010383", "map_id": "WBGene00010383", "name": "mpst-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10571221", "map_id": "none", "name": "MPST transfers sulfur from sulfanegen to HCN to form HSCN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_9013543", "map_id": "none", "name": "sulfanegen", "type": "reactant", "sub_type": "other", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10564244", "map_id": "none", "name": "ADO oxidises 2AET to HTAU", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_6814151", "map_id": "CHEBI:17141", "name": "2AET", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_1655445", "map_id": "CHEBI:16668", "name": "HTAU", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10564241", "map_id": "none", "name": "ADO:Fe2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q8IAA1", "map_id": "Q8IAA1", "name": "ADO", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021750", "map_id": "WBGene00021750", "name": "ADO", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10570934", "map_id": "none", "name": "MPST transfers sulfur atom from 3MPYR to HSO3- to form S2O3(2-) and PYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_9012724", "map_id": "CHEBI:17137", "name": "HSO3-", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10536540", "map_id": "none", "name": "Cysteine is degraded to serine and H2S", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_200736", "map_id": "CHEBI:33384", "name": "L-Ser", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "reaction_10536543", "map_id": "none", "name": "Homocysteine is degraded to oxobutanoate and H2S", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29382", "map_id": "CHEBI:16134", "name": "NH3", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_936714", "map_id": "CHEBI:30831", "name": "2OBUTA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10507392", "map_id": "none", "name": "Transport of Citrate from Mitochondrial Matrix to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29654", "map_id": "CHEBI:30769", "name": "CIT", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_76190", "map_id": "CHEBI:30769", "name": "CIT", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10507389", "map_id": "P34519", "name": "SLC25A1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "WBGene00010780", "map_id": "WBGene00010780", "name": "SLC25A1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10556609", "map_id": "none", "name": "PPT1 hydrolyses palmitoylated proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_1605715", "map_id": "CHEBI:15377", "name": "H2O", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_5690533", "map_id": "none", "name": "PALM:protein", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "true" }, { "id": "species_390435", "map_id": "CHEBI:15756", "name": "PALM", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_6785219", "map_id": "CHEBI:36080", "name": "protein", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_5690516", "map_id": "CHEBI:15756", "name": "PALM", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_10556606", "map_id": "Q20390", "name": "ppt-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "WBGene00004092", "map_id": "WBGene00004092", "name": "ppt-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10527328", "map_id": "none", "name": "ACSL3,4 ligate CoA to AA to form AA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29768", "map_id": "CHEBI:15843", "name": "AA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_76194", "map_id": "CHEBI:15346", "name": "CoA-SH", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_548819", "map_id": "CHEBI:15514", "name": "AA-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10527325", "map_id": "none", "name": "ACSL3,4", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "A0A4V0ING4", "map_id": "A0A4V0ING4", "name": "acs-17", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016716", "map_id": "WBGene00016716", "name": "acs-17", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10527264", "map_id": "none", "name": "ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29508", "map_id": "CHEBI:15531", "name": "Mal-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_113528", "map_id": "CHEBI:16526", "name": "CO2", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_548816", "map_id": "CHEBI:63821", "name": "3ODCT-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10527261", "map_id": "P49191", "name": "elo-3", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "WBGene00001241", "map_id": "WBGene00001241", "name": "elo-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10555303", "map_id": "none", "name": "PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_5676631", "map_id": "CHEBI:15456", "name": "VLC3HA-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_5676634", "map_id": "CHEBI:50998", "name": "2,3-TE-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10555300", "map_id": "none", "name": "PTPLs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "O17040", "map_id": "O17040", "name": "hpo-8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020517", "map_id": "WBGene00020517", "name": "hpo-8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10527321", "map_id": "none", "name": "TECR,TECRL dehydrogenate TOD-CoA to ST-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29364", "map_id": "CHEBI:16474", "name": "NADPH", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_548809", "map_id": "CHEBI:50570", "name": "TOD-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_428139", "map_id": "CHEBI:15541", "name": "ST-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_29366", "map_id": "CHEBI:18009", "name": "NADP+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10527316", "map_id": "Q9N5Y2", "name": "art-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "WBGene00000198", "map_id": "WBGene00000198", "name": "art-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10527308", "map_id": "none", "name": "ELOVL3,6,7 elongate PALM-CoA and Mal-CoA to 3OOD-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_200993", "map_id": "CHEBI:15525", "name": "PALM-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_548812", "map_id": "CHEBI:50571", "name": "3OOD-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10527305", "map_id": "none", "name": "ELOVL3,6,7", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q9NAC6", "map_id": "Q9NAC6", "name": "elo-9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001247", "map_id": "WBGene00001247", "name": "elo-9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q20300", "map_id": "Q20300", "name": "elo-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001243", "map_id": "WBGene00001243", "name": "elo-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EEE5", "map_id": "G5EEE5", "name": "elo-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001239", "map_id": "WBGene00001239", "name": "elo-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XVQ9", "map_id": "Q9XVQ9", "name": "elo-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001240", "map_id": "WBGene00001240", "name": "elo-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q20303", "map_id": "Q20303", "name": "elo-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001244", "map_id": "WBGene00001244", "name": "elo-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P49191", "map_id": "P49191", "name": "elo-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q20904", "map_id": "Q20904", "name": "elo-7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001245", "map_id": "WBGene00001245", "name": "elo-7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q03574", "map_id": "Q03574", "name": "elo-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001242", "map_id": "WBGene00001242", "name": "elo-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10514751", "map_id": "none", "name": "ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_3632881", "map_id": "CHEBI:15756", "name": "PALM", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10514748", "map_id": "none", "name": "ACSL1,3,5,6", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q9XWD1", "map_id": "Q9XWD1", "name": "acs-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013575", "map_id": "WBGene00013575", "name": "acs-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O16775", "map_id": "O16775", "name": "acs-15", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019920", "map_id": "WBGene00019920", "name": "acs-15", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "V6CLI5", "map_id": "V6CLI5", "name": "acs-13", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022037", "map_id": "WBGene00022037", "name": "acs-13", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O44560", "map_id": "O44560", "name": "acs-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020343", "map_id": "WBGene00020343", "name": "acs-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q21872", "map_id": "Q21872", "name": "acs-18", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011173", "map_id": "WBGene00011173", "name": "acs-18", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q20121", "map_id": "Q20121", "name": "acs-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018152", "map_id": "WBGene00018152", "name": "acs-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10527311", "map_id": "none", "name": "HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_548836", "map_id": "CHEBI:50583", "name": "3HODC-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10513362", "map_id": "Q10130", "name": "dhs-5", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "WBGene00000969", "map_id": "WBGene00000969", "name": "dhs-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10507383", "map_id": "none", "name": "ACLY tetramer transforms CIT to Ac-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29372", "map_id": "CHEBI:43474", "name": "Pi", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_76183", "map_id": "CHEBI:15351", "name": "Ac-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_76213", "map_id": "CHEBI:30744", "name": "OA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10507375", "map_id": "none", "name": "ACLY tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P53585", "map_id": "P53585", "name": "acly-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016995", "map_id": "WBGene00016995", "name": "acly-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10507381", "map_id": "Q23243", "name": "morc-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00022531", "map_id": "WBGene00022531", "name": "morc-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10514618", "map_id": "none", "name": "acetyl-CoA + bicarbonate + ATP => malonyl-CoA + H2O + ADP + orthophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_111627", "map_id": "CHEBI:17544", "name": "HCO3-", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10507411", "map_id": "none", "name": "Homologues of Btn-ACACA", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9XUC3", "map_id": "Q9XUC3", "name": "Btn-ACACA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012131", "map_id": "WBGene00012131", "name": "Btn-ACACA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "H2L0M0", "map_id": "H2L0M0", "name": "phospho-pod-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004076", "map_id": "WBGene00004076", "name": "phospho-pod-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10556619", "map_id": "none", "name": "SCD desaturates ST-CoA to OLE-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_4085415", "map_id": "CHEBI:16518", "name": "Fe(2+)Cb5", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_4085425", "map_id": "CHEBI:18097", "name": "Fe(3+)Cb5", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_5690558", "map_id": "CHEBI:15534", "name": "OLE-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10556616", "map_id": "none", "name": "SCD dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "G5EGN2", "map_id": "G5EGN2", "name": "fat-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001398", "map_id": "WBGene00001398", "name": "fat-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10510254", "map_id": "none", "name": "Formation of fatty acid synthase (FAS) dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10507450", "map_id": "P91871", "name": "phospho-fasn-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00009342", "map_id": "WBGene00009342", "name": "phospho-fasn-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10507452", "map_id": "none", "name": "FASN dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P91871", "map_id": "P91871", "name": "phospho-fasn-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10507455", "map_id": "none", "name": "acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10564542", "map_id": "none", "name": "SCD5 desaturates ST-CoA to OLE-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10564539", "map_id": "none", "name": "SCD5 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "G5ED44", "map_id": "G5ED44", "name": "fat-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001397", "map_id": "WBGene00001397", "name": "fat-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EGH6", "map_id": "G5EGH6", "name": "fat-7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001399", "map_id": "WBGene00001399", "name": "fat-7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10571480", "map_id": "none", "name": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(R)-HEPE to 18(R)-RvE1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9023708", "map_id": "CHEBI:138563", "name": "5S,6S-epoxy-18(R)-HEPE", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_9023712", "map_id": "CHEBI:81559", "name": "18(R)-RvE1", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10517863", "map_id": "none", "name": "LTA4H:Zn2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "G5EFT4", "map_id": "G5EFT4", "name": "ltah-1.1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016589", "map_id": "WBGene00016589", "name": "ltah-1.1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10571482", "map_id": "none", "name": "GPX4-2 reduces 18(R)-HpEPE to 18(R)-HEPE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9023653", "map_id": "CHEBI:138565", "name": "18(R)-HpEPE", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_29450", "map_id": "CHEBI:16856", "name": "GSH", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_9023651", "map_id": "CHEBI:81563", "name": "18(R)-HEPE", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_111745", "map_id": "CHEBI:17858", "name": "GSSG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10571475", "map_id": "A8WFK6", "name": "gpx-7", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00019846", "map_id": "WBGene00019846", "name": "gpx-7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10569921", "map_id": "none", "name": "PEX2:PEX10:PEX12 monoubiquitinates PEX5S,L at cysteine-11", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane" }, { "id": "species_10569909", "map_id": "none", "name": "PEX2:PEX10:PEX12:PEX5S,L:Ub:UBE2D1,2,3:PEX13:PEX14", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane", "complex": "true" }, { "id": "P35129", "map_id": "P35129", "name": "let-70", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002344", "map_id": "WBGene00002344", "name": "let-70", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P91853", "map_id": "P91853", "name": "uev-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006732", "map_id": "WBGene00006732", "name": "uev-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q17720", "map_id": "Q17720", "name": "ubc-22", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006717", "map_id": "WBGene00006717", "name": "ubc-22", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q20617", "map_id": "Q20617", "name": "ubc-24", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006719", "map_id": "WBGene00006719", "name": "ubc-24", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q19951", "map_id": "Q19951", "name": "prx-13", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004198", "map_id": "WBGene00004198", "name": "prx-13", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q93930", "map_id": "Q93930", "name": "prx-14", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004199", "map_id": "WBGene00004199", "name": "prx-14", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q18355", "map_id": "Q18355", "name": "PEX10", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016318", "map_id": "WBGene00016318", "name": "PEX10", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q19189", "map_id": "Q19189", "name": "prx-12", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004197", "map_id": "WBGene00004197", "name": "prx-12", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q18426", "map_id": "Q18426", "name": "prx-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004194", "map_id": "WBGene00004194", "name": "prx-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10569918", "map_id": "none", "name": "PEX2:PEX10:PEX12:Ub:PEX5S,L:PEX13:PEX14", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane", "complex": "true" }, { "id": "species_10532186", "map_id": "none", "name": "UBE2D1,2,3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10569911", "map_id": "none", "name": "PEX2:PEX10:PEX12 binds PEX5S,L (in PEX5S:PEX13:PEX14) and Ub:UBE2D1,2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane" }, { "id": "species_10569900", "map_id": "none", "name": "PEX5S,L:PEX13:PEX14:PEX2:PEX10:PEX12", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane", "complex": "true" }, { "id": "species_10569907", "map_id": "none", "name": "Ub:UBE2D1,2,3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10568412", "map_id": "none", "name": "RNF152 polyubiquitinates RRAGA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10568399", "map_id": "none", "name": "Ub:UBE2N", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10568401", "map_id": "none", "name": "RNF152:RRAGA:GDP:Ub:UBE2N", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "Q19214", "map_id": "Q19214", "name": "TRIM32", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008588", "map_id": "WBGene00008588", "name": "TRIM32", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q22743", "map_id": "Q22743", "name": "raga-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006414", "map_id": "WBGene00006414", "name": "raga-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10568392", "map_id": "Q19214", "name": "RNF152", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "false" }, { "id": "species_10568409", "map_id": "none", "name": "K63polyUb-K142,K220,K230,K244-RRAGA:GDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10515250", "map_id": "Q95XX0", "name": "ubc-13", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10568414", "map_id": "none", "name": "RNF152 binds RRAGA:GDP and Ubiquitin:UBE2D3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10568394", "map_id": "none", "name": "RRAGA:GDP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10551718", "map_id": "none", "name": "SYVN1 ubiquitinates Hh C-terminal fragments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10551711", "map_id": "none", "name": "C-terminal Hh fragments:ERLEC/OS9:SEL1:SYVN1dimer:DERL2:VCP hexamer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q09396", "map_id": "Q09396", "name": "OS9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018611", "map_id": "WBGene00018611", "name": "OS9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9NF22", "map_id": "Q9NF22", "name": "ERLEC1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013667", "map_id": "WBGene00013667", "name": "ERLEC1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EFG0", "map_id": "G5EFG0", "name": "sel-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004759", "map_id": "WBGene00004759", "name": "sel-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q21997", "map_id": "Q21997", "name": "DERL2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020109", "map_id": "WBGene00020109", "name": "DERL2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P54812", "map_id": "P54812", "name": "cdc-48.2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008053", "map_id": "WBGene00008053", "name": "cdc-48.2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q20798", "map_id": "Q20798", "name": "sel-11", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004768", "map_id": "WBGene00004768", "name": "sel-11", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10551715", "map_id": "none", "name": "ub-C-terminal Hh fragments:ERLEC/OS9:SEL1:SYVN1dimer:DERL2:VCP hexamer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10552665", "map_id": "none", "name": "GPR161 promotes cAMP production in a G alpha(s)-dependent manner", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_30389", "map_id": "CHEBI:17489", "name": "cAMP", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10552658", "map_id": "none", "name": "adenylate cyclases:Mg2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10552663", "map_id": "none", "name": "GPR161:IFT-A:TULP3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_18730", "compartment_display": "cilium", "complex": "true" }, { "id": "Q09306", "map_id": "Q09306", "name": "tub-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006655", "map_id": "WBGene00006655", "name": "tub-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q20255", "map_id": "Q20255", "name": "ift-139", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022696", "map_id": "WBGene00022696", "name": "ift-139", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q18859", "map_id": "Q18859", "name": "ifta-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016935", "map_id": "WBGene00016935", "name": "ifta-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EFW7", "map_id": "G5EFW7", "name": "daf-10", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000906", "map_id": "WBGene00000906", "name": "daf-10", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5ECZ4", "map_id": "G5ECZ4", "name": "dyf-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001118", "map_id": "WBGene00001118", "name": "dyf-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P90757", "map_id": "P90757", "name": "che-11", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000490", "map_id": "WBGene00000490", "name": "che-11", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10552670", "map_id": "none", "name": "NUMB binds ITCH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10524550", "map_id": "Q9XTY6", "name": "num-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "WBGene00003830", "map_id": "WBGene00003830", "name": "num-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10530869", "map_id": "Q9N2Z7", "name": "wwp-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00007009", "map_id": "WBGene00007009", "name": "wwp-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10552668", "map_id": "none", "name": "NUMB:ITCH", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9N2Z7", "map_id": "Q9N2Z7", "name": "wwp-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XTY6", "map_id": "Q9XTY6", "name": "num-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10552682", "map_id": "none", "name": "cAMP dissociates PKA, promoting GLI processing", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5263232", "compartment_display": "ciliary base" }, { "id": "species_10552678", "map_id": "none", "name": "PKA tetramer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5263232", "compartment_display": "ciliary base", "complex": "true" }, { "id": "P21137", "map_id": "P21137", "name": "kin-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002189", "map_id": "WBGene00002189", "name": "kin-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P30625", "map_id": "P30625", "name": "kin-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002190", "map_id": "WBGene00002190", "name": "kin-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10552680", "map_id": "none", "name": "PKA regulatory subunits:cAMP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5263232", "compartment_display": "ciliary base", "complex": "true" }, { "id": "species_10552672", "map_id": "P21137", "name": "kin-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5263232", "compartment_display": "ciliary base", "complex": "false" }, { "id": "reaction_10552654", "map_id": "none", "name": "The IFT-A complex recruits TULP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_18730", "compartment_display": "cilium" }, { "id": "species_10552650", "map_id": "none", "name": "IFT-A complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_18730", "compartment_display": "cilium", "complex": "true" }, { "id": "species_10552619", "map_id": "Q09306", "name": "tub-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_18730", "compartment_display": "cilium", "complex": "false" }, { "id": "species_10552652", "map_id": "none", "name": "IFT-A complex:TULP3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_18730", "compartment_display": "cilium", "complex": "true" }, { "id": "reaction_10554098", "map_id": "none", "name": "GLI2,3 are degraded by the proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10554096", "map_id": "none", "name": "ub-2p-GLI2,3:SPOP:CUL3:RBX1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q23457", "map_id": "Q23457", "name": "rbx-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004320", "map_id": "WBGene00004320", "name": "rbx-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34568", "map_id": "P34568", "name": "bath-43", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011815", "map_id": "WBGene00011815", "name": "bath-43", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9NF14", "map_id": "Q9NF14", "name": "bath-40", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013689", "map_id": "WBGene00013689", "name": "bath-40", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "H2KYJ3", "map_id": "H2KYJ3", "name": "bath-44", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00015567", "map_id": "WBGene00015567", "name": "bath-44", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P41886", "map_id": "P41886", "name": "bath-41", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018137", "map_id": "WBGene00018137", "name": "bath-41", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q94420", "map_id": "Q94420", "name": "mel-26", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003209", "map_id": "WBGene00003209", "name": "mel-26", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34371", "map_id": "P34371", "name": "bath-42", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016803", "map_id": "WBGene00016803", "name": "bath-42", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q17391", "map_id": "Q17391", "name": "cul-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000838", "map_id": "WBGene00000838", "name": "cul-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10554094", "map_id": "none", "name": "SPOP:CUL3:RBX1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10502318", "map_id": "none", "name": "Ub", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10512606", "map_id": "none", "name": "26S proteasome", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10554020", "map_id": "none", "name": "PTCH is internalized", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_261122", "compartment_display": "ciliary membrane" }, { "id": "species_10554012", "map_id": "none", "name": "Homologues of ub-PTCH1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_261122", "compartment_display": "ciliary membrane", "complex": "true" }, { "id": "H2L0G5", "map_id": "H2L0G5", "name": "ptc-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004210", "map_id": "WBGene00004210", "name": "ptc-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q09614", "map_id": "Q09614", "name": "ptc-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004208", "map_id": "WBGene00004208", "name": "ptc-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10554018", "map_id": "none", "name": "Homologues of ub-PTCH1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_24337", "compartment_display": "endocytic vesicle membrane", "complex": "true" }, { "id": "reaction_10554105", "map_id": "none", "name": "SPOP:CUL3:RBX1 ubiquitinates GLI2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10554102", "map_id": "none", "name": "2p-GLI:SPOP:CUL3:RBX1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10557600", "map_id": "none", "name": "GSTO1 dimer reduces methylarsonate to methylarsonite", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5696214", "map_id": "CHEBI:16005", "name": "methylarsonate", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_5696224", "map_id": "CHEBI:14597", "name": "methylarsonite", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10511838", "map_id": "none", "name": "GSTO1 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P34345", "map_id": "P34345", "name": "gsto-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016204", "map_id": "WBGene00016204", "name": "gsto-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10511831", "map_id": "none", "name": "NNMT transfers CH3 from AdoMet to PY", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_175973", "map_id": "CHEBI:16227", "name": "PY", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_71284", "map_id": "CHEBI:15414", "name": "AdoMet", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_175979", "map_id": "CHEBI:15761", "name": "MP+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_71285", "map_id": "CHEBI:16680", "name": "AdoHcy", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10511828", "map_id": "P34254", "name": "anmt-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00015124", "map_id": "WBGene00015124", "name": "anmt-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10511767", "map_id": "none", "name": "MTR transfers CH3 from MeCbl to HCYS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10511760", "map_id": "none", "name": "MTRR:MTR(MeCbl)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_73524", "map_id": "CHEBI:17621", "name": "FMN", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "Q17574", "map_id": "Q17574", "name": "mtrr-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006510", "map_id": "WBGene00006510", "name": "mtrr-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_113596", "map_id": "CHEBI:16238", "name": "FAD", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "CHEBI:28115", "map_id": "CHEBI:28115", "name": "CHEBI:28115", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q09582", "map_id": "Q09582", "name": "metr-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010988", "map_id": "WBGene00010988", "name": "metr-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_174390", "map_id": "CHEBI:57844", "name": "L-Met", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10511764", "map_id": "none", "name": "MTRR:MTR(cob(I)alamin)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_3159260", "map_id": "CHEBI:15982", "name": "cob(I)alamin", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10511802", "map_id": "none", "name": "AHCY:NAD+ tetramer hydrolyses AdoHcy", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_83909", "map_id": "CHEBI:16335", "name": "Ade-Rib", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10511799", "map_id": "none", "name": "AHCY:NAD+ tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_29360", "map_id": "CHEBI:57540", "name": "NAD+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "P27604", "map_id": "P27604", "name": "ahcy-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019322", "map_id": "WBGene00019322", "name": "ahcy-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10562143", "map_id": "none", "name": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to MMAIII", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_6806829", "map_id": "CHEBI:17826", "name": "MMAIII", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_6800127", "map_id": "CHEBI:48765", "name": "DMAA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10562137", "map_id": "none", "name": "N6AMT1:TRMT112", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "O16582", "map_id": "O16582", "name": "mtq-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016341", "map_id": "WBGene00016341", "name": "mtq-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O45241", "map_id": "O45241", "name": "TRMT112", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007312", "map_id": "WBGene00007312", "name": "TRMT112", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10509986", "map_id": "none", "name": "SULT1A3,4 dimers sulfate DA to DAOS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_158471", "map_id": "CHEBI:17980", "name": "PAPS", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_159362", "map_id": "CHEBI:18243", "name": "DA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_159352", "map_id": "CHEBI:37946", "name": "DAOS", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_158466", "map_id": "CHEBI:17985", "name": "PAP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10509940", "map_id": "none", "name": "SULT1A1 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9U2Z2", "map_id": "Q9U2Z2", "name": "ssu-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013748", "map_id": "WBGene00013748", "name": "ssu-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10511970", "map_id": "none", "name": "SULTs transfer (SO4)2- group to PREG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_193103", "map_id": "CHEBI:16581", "name": "PREG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_176665", "map_id": "CHEBI:35420", "name": "PREGS", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10511967", "map_id": "none", "name": "SULTs active on pregnenolone", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10512002", "map_id": "none", "name": "dehydroepiandrosterone (DHEA) + PAPS => DHEA sulfate + PAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_176626", "map_id": "CHEBI:28689", "name": "DHEA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_176496", "map_id": "CHEBI:16814", "name": "DHEA-SO4", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10511999", "map_id": "none", "name": "SULTs active on DHEA", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10511777", "map_id": "none", "name": "PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_174370", "map_id": "CHEBI:17709", "name": "APS", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10511772", "map_id": "A0A061AE05", "name": "pps-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00004091", "map_id": "WBGene00004091", "name": "pps-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10522868", "map_id": "none", "name": "SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_351626", "map_id": "CHEBI:15378", "name": "H+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_427648", "map_id": "CHEBI:16189", "name": "SO4(2-)", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10522865", "map_id": "none", "name": "SLC26A1,2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "O17951", "map_id": "O17951", "name": "sulp-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010789", "map_id": "WBGene00010789", "name": "sulp-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EEA7", "map_id": "G5EEA7", "name": "sulp-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010788", "map_id": "WBGene00010788", "name": "sulp-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O45016", "map_id": "O45016", "name": "sulp-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020914", "map_id": "WBGene00020914", "name": "sulp-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EED0", "map_id": "G5EED0", "name": "sulp-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016945", "map_id": "WBGene00016945", "name": "sulp-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q94225", "map_id": "Q94225", "name": "sulp-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018283", "map_id": "WBGene00018283", "name": "sulp-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EFB2", "map_id": "G5EFB2", "name": "sulp-8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013963", "map_id": "WBGene00013963", "name": "sulp-8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EC30", "map_id": "G5EC30", "name": "sulp-7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012259", "map_id": "WBGene00012259", "name": "sulp-7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10511780", "map_id": "none", "name": "PAPSS1,2 transfer SO4(2-) group to ATP to form APS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10527852", "map_id": "none", "name": "SLC35B2,3 transport cytosolic PAPS to Golgi lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_741440", "map_id": "CHEBI:17980", "name": "PAPS", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10527849", "map_id": "none", "name": "SLC35B2,3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "Q8MXJ9", "map_id": "Q8MXJ9", "name": "pst-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004206", "map_id": "WBGene00004206", "name": "pst-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q20787", "map_id": "Q20787", "name": "pst-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018827", "map_id": "WBGene00018827", "name": "pst-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10511973", "map_id": "none", "name": "beta-estradiol + PAPS => beta-estradiol 3-sulfate + PAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_176619", "map_id": "CHEBI:16469", "name": "E2", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_176492", "map_id": "CHEBI:4866", "name": "E2-SO4", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10511945", "map_id": "none", "name": "SULT1E1 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10569867", "map_id": "none", "name": "IMPAD1 hydrolyses PAP to AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "species_742343", "map_id": "CHEBI:17985", "name": "PAP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_2022884", "map_id": "CHEBI:15377", "name": "H2O", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_8851226", "map_id": "CHEBI:43474", "name": "Pi", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_8953493", "map_id": "CHEBI:16027", "name": "adenosine 5'-monophosphate", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10569864", "map_id": "none", "name": "IMPAD1:Mg2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "Q5ZEQ3", "map_id": "Q5ZEQ3", "name": "gpap-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012390", "map_id": "WBGene00012390", "name": "gpap-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_8953505", "map_id": "CHEBI:49713", "name": "Li+", "type": "inhibitor", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "reaction_10512011", "map_id": "none", "name": "p-nitrophenol + PAPS => p-nitrophenol sulfate + PAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5695950", "map_id": "CHEBI:16836", "name": "PNP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_176600", "map_id": "CHEBI:35422", "name": "p-nitrophenol sulfate", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10512008", "map_id": "none", "name": "SULT1A1,A2,C2,4A1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10511982", "map_id": "none", "name": "3,5,3'-triiodothyronine + PAPS => 3,5,3'-triiodothyronine 4-sulfate + PAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_176667", "map_id": "CHEBI:28774", "name": "T3", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_176564", "map_id": "CHEBI:35432", "name": "3,5,3'-triiodothyronine 4-sulfate", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10511979", "map_id": "none", "name": "SULT dimers (T3)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10512016", "map_id": "none", "name": "estrone + PAPS => estrone 3-sulfate + PAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_176575", "map_id": "CHEBI:17263", "name": "E1", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_176501", "map_id": "CHEBI:17474", "name": "E1S", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10512013", "map_id": "none", "name": "SULT1E1,2A1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10511985", "map_id": "none", "name": "lithocholate + PAPS => lithocholate sulfate + PAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_176655", "map_id": "CHEBI:16325", "name": "LCA", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_176555", "map_id": "CHEBI:35421", "name": "lithocholate sulfate", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10511949", "map_id": "none", "name": "SULT2A1 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10511987", "map_id": "none", "name": "taurolithocholate + PAPS => taurolithocholate sulfate + PAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_176565", "map_id": "CHEBI:17179", "name": "taurolithocholate", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_176483", "map_id": "CHEBI:17864", "name": "taurolithocholate sulfate", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10512021", "map_id": "none", "name": "N-hydroxy-2-acetylaminofluorene + PAPS => 2-acetylaminofluorene-N-sulfate + PAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_176566", "map_id": "CHEBI:17931", "name": "N-hydroxy-2-acetylaminofluorene", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_176500", "map_id": "CHEBI:35424", "name": "AAF-N-S", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10512018", "map_id": "none", "name": "SULTs active on NH2AAF", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10511958", "map_id": "none", "name": "3,3'-diiodothyronine + PAPS => 3,3'-diiodothyronine 4-sulfate + PAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_176486", "map_id": "CHEBI:35430", "name": "3,3'-diiodothyronine", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_176519", "map_id": "CHEBI:35431", "name": "3,3'-diiodothyronine 4-sulfate", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10511955", "map_id": "none", "name": "SULT dimers (T2)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10509943", "map_id": "none", "name": "SULT1A1 dimer sulfonates PARA to PARA-SO4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_158469", "map_id": "CHEBI:46195", "name": "PARA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_158472", "map_id": "CHEBI:32635", "name": "PARA-SO4", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10511995", "map_id": "none", "name": "Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10511992", "map_id": "Q23493", "name": "bpnt-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00044063", "map_id": "WBGene00044063", "name": "bpnt-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10509949", "map_id": "none", "name": "Phenol can form a sulfate conjugate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_158858", "map_id": "CHEBI:15882", "name": "PhOH", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_158850", "map_id": "CHEBI:27905", "name": "Phenyl sulfate", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10511997", "map_id": "none", "name": "cholesterol + PAPS => cholesterol sulfate + PAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_176478", "map_id": "CHEBI:16113", "name": "CHOL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_176618", "map_id": "CHEBI:41321", "name": "cholesterol sulfate", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10511962", "map_id": "none", "name": "SULT2B1-2 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10511965", "map_id": "none", "name": "SULTs transfer (SO4)2- group to 27HCHOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_176617", "map_id": "CHEBI:17703", "name": "27HCHOL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_176502", "map_id": "CHEBI:35419", "name": "27HCHOL3S", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10509951", "map_id": "none", "name": "SULT1A1 dimer sulfonates NHABP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_158847", "map_id": "CHEBI:16580", "name": "NHABP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_158859", "map_id": "CHEBI:32701", "name": "NHABP-SO4", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10510057", "map_id": "none", "name": "benzoyl-CoA + glycine => benzoyl glycine (hippuric acid) + Coenzyme A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_159549", "map_id": "CHEBI:57305", "name": "Gly", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_159447", "map_id": "CHEBI:15515", "name": "BEZ-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_29374", "map_id": "CHEBI:15346", "name": "CoA-SH", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_159564", "map_id": "CHEBI:18089", "name": "HIPA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10510054", "map_id": "none", "name": "GLYAT-like proteins", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q95ZT6", "map_id": "Q95ZT6", "name": "GLYAT", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018400", "map_id": "WBGene00018400", "name": "GLYAT", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q22371", "map_id": "Q22371", "name": "GLYAT", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10510059", "map_id": "none", "name": "salicylate-CoA + glycine => salicyluric acid + Coenzyme A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_159557", "map_id": "CHEBI:32587", "name": "Salicylate-CoA thioester", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_159572", "map_id": "CHEBI:9008", "name": "SUA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10511744", "map_id": "none", "name": "SLC35D1 hexamer transports UDP-GlcA, UDP-GlcNAc from cytosol to endoplasmic reticulum lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_158601", "map_id": "CHEBI:17200", "name": "UDP-GlcA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_162756", "map_id": "CHEBI:16264", "name": "UDP-GlcNAc", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_3499326", "map_id": "CHEBI:16264", "name": "UDP-GlcNAc", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_174384", "map_id": "CHEBI:17200", "name": "UDP-GlcA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10511741", "map_id": "none", "name": "SLC35D1 hexamer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q18779", "map_id": "Q18779", "name": "sqv-7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00005025", "map_id": "WBGene00005025", "name": "sqv-7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10502868", "map_id": "none", "name": "UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29494", "map_id": "CHEBI:15713", "name": "UTP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10502865", "map_id": "none", "name": "8xUGP2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9XUS5", "map_id": "Q9XUS5", "name": "UGP2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010665", "map_id": "WBGene00010665", "name": "UGP2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10511557", "map_id": "none", "name": "UDP-glucose is oxidised to UDP-glucuronate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_73473", "map_id": "CHEBI:57945", "name": "NADH", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10511554", "map_id": "none", "name": "6xUGDH", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q19905", "map_id": "Q19905", "name": "sqv-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00005022", "map_id": "WBGene00005022", "name": "sqv-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10557073", "map_id": "none", "name": "ESD dimer hydrolyses S-FGSH to GSH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_113519", "map_id": "CHEBI:15377", "name": "H2O", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_5693723", "map_id": "CHEBI:16225", "name": "S-FGSH", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_158543", "map_id": "CHEBI:16856", "name": "GSH", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_194712", "map_id": "CHEBI:30751", "name": "formate", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10557070", "map_id": "none", "name": "ESD dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "G5EF86", "map_id": "G5EF86", "name": "ESD", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013018", "map_id": "WBGene00013018", "name": "ESD", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10547222", "map_id": "none", "name": "GSTK1 dimer transfers GS from GSH to CDNB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_1655887", "map_id": "CHEBI:16856", "name": "GSH", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_3301954", "map_id": "CHEBI:34718", "name": "CDNB", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_3301973", "map_id": "CHEBI:17883", "name": "HCl", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_3301969", "map_id": "CHEBI:8927", "name": "DNPSG", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10547219", "map_id": "none", "name": "GSTK1 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q18973", "map_id": "Q18973", "name": "gstk-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017054", "map_id": "WBGene00017054", "name": "gstk-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10532353", "map_id": "none", "name": "OPLAH hydrolyses OPRO to L-Glu", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1247942", "map_id": "CHEBI:18183", "name": "OPRO", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_29404", "map_id": "CHEBI:29985", "name": "L-Glu", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10532350", "map_id": "none", "name": "OPLAH", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "A0A9S2", "map_id": "A0A9S2", "name": "OPLAH", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021430", "map_id": "WBGene00021430", "name": "OPLAH", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10511734", "map_id": "none", "name": "GCL ligates L-Glu to L-Cys", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_174393", "map_id": "CHEBI:17515", "name": "gGluCys", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10511731", "map_id": "none", "name": "GCL", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "A9CZN9", "map_id": "A9CZN9", "name": "GCLM", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017084", "map_id": "WBGene00017084", "name": "GCLM", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q20117", "map_id": "Q20117", "name": "gcs-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001527", "map_id": "WBGene00001527", "name": "gcs-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10532343", "map_id": "none", "name": "GGCT transforms gGluCys to OPRO", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10532340", "map_id": "none", "name": "GGCT dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q18596", "map_id": "Q18596", "name": "GGCT", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016629", "map_id": "WBGene00016629", "name": "GGCT", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10568716", "map_id": "none", "name": "GGT dimers hydrolyse GSH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_1247892", "map_id": "CHEBI:16856", "name": "GSH", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_1247934", "map_id": "CHEBI:4047", "name": "CysGly", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10532333", "map_id": "none", "name": "CNDP2:2Mn2+ dimer hydrolyses CysGly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1247904", "map_id": "CHEBI:4047", "name": "CysGly", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_29424", "map_id": "CHEBI:57305", "name": "Gly", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10532330", "map_id": "none", "name": "CNDP2:2Mn2+ dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "O18000", "map_id": "O18000", "name": "pes-9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003982", "map_id": "WBGene00003982", "name": "pes-9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10511790", "map_id": "none", "name": "GSS:Mg2+ dimer synthesizes GSH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10511787", "map_id": "none", "name": "GSS:Mg2+ dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q21549", "map_id": "Q21549", "name": "gss-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010941", "map_id": "WBGene00010941", "name": "gss-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10511885", "map_id": "none", "name": "GST dimers conjugate GSH with cytosolic substrates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_176070", "map_id": "none", "name": "Electrophilic substrate", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:29132", "map_id": "CHEBI:29132", "name": "CHEBI:29132", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:30614", "map_id": "CHEBI:30614", "name": "CHEBI:30614", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_176049", "map_id": "none", "name": "electrophilic substrate:SG", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:32639", "map_id": "CHEBI:32639", "name": "CHEBI:32639", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:34479", "map_id": "CHEBI:34479", "name": "CHEBI:34479", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10511882", "map_id": "none", "name": "GST dimers", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q18938", "map_id": "Q18938", "name": "gst-42", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001790", "map_id": "WBGene00001790", "name": "gst-42", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34277", "map_id": "P34277", "name": "gsto-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00015337", "map_id": "WBGene00015337", "name": "gsto-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "D7SFI3", "map_id": "D7SFI3", "name": "GSTO2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00043097", "map_id": "WBGene00043097", "name": "GSTO2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O17234", "map_id": "O17234", "name": "gsto-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019636", "map_id": "WBGene00019636", "name": "gsto-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O45352", "map_id": "O45352", "name": "gst-44", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001792", "map_id": "WBGene00001792", "name": "gst-44", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q09607", "map_id": "Q09607", "name": "gst-36", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001784", "map_id": "WBGene00001784", "name": "gst-36", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P10299", "map_id": "P10299", "name": "gst-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001749", "map_id": "WBGene00001749", "name": "gst-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10556844", "map_id": "none", "name": "AKR1A1 oxidises BaPtDHD to BaP-7,8-dione", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5692212", "map_id": "CHEBI:81626", "name": "BaPtDHD", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_5692216", "map_id": "CHEBI:87752", "name": "BaP-7,8-dione", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10554514", "map_id": "Q9NAI5", "name": "AKR1A1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00012722", "map_id": "WBGene00012722", "name": "AKR1A1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10510318", "map_id": "none", "name": "Furin cleaves pro-GAS6 to GAS6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10510296", "map_id": "none", "name": "Homologues of 11xCbxE-GAS6(31-691)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "G5EFX3", "map_id": "G5EFX3", "name": "phospho-p-GAS6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013416", "map_id": "WBGene00013416", "name": "phospho-p-GAS6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XWD6", "map_id": "Q9XWD6", "name": "phospho-ced-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000415", "map_id": "WBGene00000415", "name": "phospho-ced-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10510310", "map_id": "none", "name": "Homologues of GAS6(31-38)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "species_10510304", "map_id": "none", "name": "Homologues of 11xCbxE-GAS6(39-691)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "species_10510315", "map_id": "O17798", "name": "kpc-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "WBGene00002232", "map_id": "WBGene00002232", "name": "kpc-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10510298", "map_id": "none", "name": "Gamma-carboxy pro-GAS6 transport from the endoplasmic reticulum to the Golgi apparatus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13959", "compartment_display": "COPII-coated ER to Golgi transport vesicle" }, { "id": "species_10510290", "map_id": "none", "name": "Homologues of 11xCbxE-GAS6(31-691)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "reaction_10558353", "map_id": "none", "name": "FN3K phosphorylates ketosamines", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_6788868", "map_id": "none", "name": "ketoamines", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:87176", "map_id": "CHEBI:87176", "name": "CHEBI:87176", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:24103", "map_id": "CHEBI:24103", "name": "CHEBI:24103", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:87177", "map_id": "CHEBI:87177", "name": "CHEBI:87177", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_6788848", "map_id": "none", "name": "ketosamines 3-phosphate", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:87180", "map_id": "CHEBI:87180", "name": "CHEBI:87180", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:87178", "map_id": "CHEBI:87178", "name": "CHEBI:87178", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:87179", "map_id": "CHEBI:87179", "name": "CHEBI:87179", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10558348", "map_id": "Q9U2U7", "name": "FN3KRP", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00013802", "map_id": "WBGene00013802", "name": "FN3KRP", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10516057", "map_id": "none", "name": "DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10516005", "map_id": "none", "name": "Dhp-K50-EIF5A", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q20751", "map_id": "Q20751", "name": "iff-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002065", "map_id": "WBGene00002065", "name": "iff-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34563", "map_id": "P34563", "name": "iff-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002064", "map_id": "WBGene00002064", "name": "iff-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10516047", "map_id": "none", "name": "Hyp-K50-EIF5A", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10516054", "map_id": "none", "name": "DOHH:Fe++", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q17949", "map_id": "Q17949", "name": "dohh-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007555", "map_id": "WBGene00007555", "name": "dohh-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10516029", "map_id": "none", "name": "DHPS tetramer synthesizes EIF5A and spermidine from Dhp-K50-EIF5A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_204628", "map_id": "CHEBI:15725", "name": "1,3-diaminopropane", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_204635", "map_id": "CHEBI:16610", "name": "SPM", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10516019", "map_id": "none", "name": "EIF5A", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10516026", "map_id": "none", "name": "DHPS tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9XXJ0", "map_id": "Q9XXJ0", "name": "dhps-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012460", "map_id": "WBGene00012460", "name": "dhps-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10551593", "map_id": "none", "name": "DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10551582", "map_id": "P29691", "name": "eef-2", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00001167", "map_id": "WBGene00001167", "name": "eef-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10551585", "map_id": "P29691", "name": "eef-2", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10551590", "map_id": "Q17514", "name": "DPH5", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00007194", "map_id": "WBGene00007194", "name": "DPH5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10551579", "map_id": "none", "name": "DPH6 ligates ammonium to diphthine-EEF2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10551571", "map_id": "P29691", "name": "eef-2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_31633", "map_id": "CHEBI:28938", "name": "NH4+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10509919", "map_id": "P29691", "name": "eef-2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10551576", "map_id": "Q966L4", "name": "DPH6", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00017087", "map_id": "WBGene00017087", "name": "DPH6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10551615", "map_id": "none", "name": "DPH2 transfers a 3-amino-3-carboxypropyl group from AdoMet to residue 715 of nascent EEF2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10551595", "map_id": "P29691", "name": "eef-2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_353106", "map_id": "CHEBI:17509", "name": "MTAD", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10551612", "map_id": "none", "name": "DPH1:DPH2:DPH3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P49958", "map_id": "P49958", "name": "dph-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007576", "map_id": "WBGene00007576", "name": "dph-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q09454", "map_id": "Q09454", "name": "dph-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007488", "map_id": "WBGene00007488", "name": "dph-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q21102", "map_id": "Q21102", "name": "DPH3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010484", "map_id": "WBGene00010484", "name": "DPH3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10558335", "map_id": "none", "name": "ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_6788753", "map_id": "CHEBI:86019", "name": "S-FARN-Cys", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_6788758", "map_id": "CHEBI:87167", "name": "S-FARN-CME", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10558332", "map_id": "none", "name": "ICMT:Zn2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "P91402", "map_id": "P91402", "name": "ICMT", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019710", "map_id": "WBGene00019710", "name": "ICMT", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10558351", "map_id": "none", "name": "FN3KRP phosphorylates PsiAm, RibAm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_6788865", "map_id": "none", "name": "PsiAm, RibAm", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_6788858", "map_id": "none", "name": "PsiAm3P, RibAm3P", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10570837", "map_id": "none", "name": "SLIT2 binds Dystroglycan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10519315", "map_id": "G5EFX6", "name": "slt-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "WBGene00004854", "map_id": "WBGene00004854", "name": "slt-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10570833", "map_id": "none", "name": "Dystroglycan", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "O61756", "map_id": "O61756", "name": "dgn-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018943", "map_id": "WBGene00018943", "name": "dgn-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q22629", "map_id": "Q22629", "name": "dgn-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000961", "map_id": "WBGene00000961", "name": "dgn-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10570835", "map_id": "none", "name": "SLIT2:Dystroglycan", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "G5EFX6", "map_id": "G5EFX6", "name": "slt-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10564693", "map_id": "none", "name": "PLA2s hydrolyze phospholipids at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_429785", "map_id": "CHEBI:16110", "name": "PC", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "species_6814303", "map_id": "CHEBI:35366", "name": "fatty acid", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_8848483", "map_id": "CHEBI:17504", "name": "2-lysophosphatidylcholine", "type": "catalyst", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "species_10534904", "map_id": "Q95YD2", "name": "PLA2G6", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00016661", "map_id": "WBGene00016661", "name": "PLA2G6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10564918", "map_id": "none", "name": "Dynein drives COPI-independent retrograde traffic from the Golgi to the ER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10564872", "map_id": "none", "name": "RAB6:GTP:BICD dimer:COPI-independent retrograde cargo:Dynein:Dynactin:microtubules", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "Q9NA98", "map_id": "Q9NA98", "name": "arp-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013168", "map_id": "WBGene00013168", "name": "arp-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34685", "map_id": "P34685", "name": "cap-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000292", "map_id": "WBGene00000292", "name": "cap-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34686", "map_id": "P34686", "name": "cap-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000293", "map_id": "WBGene00000293", "name": "cap-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q18194", "map_id": "Q18194", "name": "dnc-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016124", "map_id": "WBGene00016124", "name": "dnc-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9N4I1", "map_id": "Q9N4I1", "name": "dnc-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022118", "map_id": "WBGene00022118", "name": "dnc-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9N3F1", "map_id": "Q9N3F1", "name": "dnc-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021827", "map_id": "WBGene00021827", "name": "dnc-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9GYR2", "map_id": "Q9GYR2", "name": "arp-11", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016793", "map_id": "WBGene00016793", "name": "arp-11", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q09248", "map_id": "Q09248", "name": "dnc-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001018", "map_id": "WBGene00001018", "name": "dnc-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "E2JKZ0", "map_id": "E2JKZ0", "name": "dnc-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001017", "map_id": "WBGene00001017", "name": "dnc-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "V6CJ04", "map_id": "V6CJ04", "name": "bicd-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016611", "map_id": "WBGene00016611", "name": "bicd-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q22782", "map_id": "Q22782", "name": "rab-6.2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004270", "map_id": "WBGene00004270", "name": "rab-6.2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34213", "map_id": "P34213", "name": "rab-6.1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004269", "map_id": "WBGene00004269", "name": "rab-6.1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8I136", "map_id": "Q8I136", "name": "gly-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001629", "map_id": "WBGene00001629", "name": "gly-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O61394", "map_id": "O61394", "name": "gly-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001631", "map_id": "WBGene00001631", "name": "gly-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10564859", "map_id": "none", "name": "BICD dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10553033", "map_id": "none", "name": "Dynein:Dynactin:microtubule", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10564898", "map_id": "none", "name": "RAB6:GTP:COPI-independent retrograde Golgi-to-ER cargo", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "species_10564916", "map_id": "none", "name": "RAB3GAP1:RAB3GAP2:RAB18:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q8MXS1", "map_id": "Q8MXS1", "name": "rab-18", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004277", "map_id": "WBGene00004277", "name": "rab-18", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q93538", "map_id": "Q93538", "name": "rbg-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004317", "map_id": "WBGene00004317", "name": "rbg-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q22670", "map_id": "Q22670", "name": "rbg-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004318", "map_id": "WBGene00004318", "name": "rbg-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10564982", "map_id": "none", "name": "RAB3GAP1:RAB3GAP2 recruits RAB18:GCDP to ER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10564910", "map_id": "none", "name": "RAB3GAP1:RAB3GAP2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "species_10564978", "map_id": "none", "name": "RAB18:GDP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10564980", "map_id": "none", "name": "RAB3GAP1:RAB3GAP2:RAB18:GDP", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10564985", "map_id": "none", "name": "RAB3GAP1:RAB3GAP2 promotes nucleotide exchange on RAB18", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "reaction_10564874", "map_id": "none", "name": "RAB6:GTP displaces PAFAH1B1 from dynein:dynactin complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10564861", "map_id": "none", "name": "RAB6:GTP:BICD dimer:COPI-independent retrograde cargo", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "species_10564870", "map_id": "none", "name": "Dynein:Dynactin:microtubules:PAFAH1B1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9NDC9", "map_id": "Q9NDC9", "name": "lis-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003047", "map_id": "WBGene00003047", "name": "lis-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10564868", "map_id": "Q9NDC9", "name": "lis-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10564863", "map_id": "none", "name": "RAB6:GTP and BICD homodimers bind COPI-independent Golgi-to-ER retrograde cargo", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10564846", "map_id": "none", "name": "COPI-independent Golgi-to-ER cargo", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "species_10564844", "map_id": "none", "name": "RAB6:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "reaction_10563841", "map_id": "none", "name": "GBF1 stimulates nucleotide exchange on ARF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10563830", "map_id": "none", "name": "RAB1:GTP:GBF1:ARF:GDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "G5EGS5", "map_id": "G5EGS5", "name": "gbf-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007703", "map_id": "WBGene00007703", "name": "gbf-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9UAQ6", "map_id": "Q9UAQ6", "name": "rab-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004266", "map_id": "WBGene00004266", "name": "rab-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q94231", "map_id": "Q94231", "name": "arf-1.1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000190", "map_id": "WBGene00000190", "name": "arf-1.1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10563834", "map_id": "none", "name": "RAB1:GTP:GBF1:ARF:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "reaction_10563843", "map_id": "none", "name": "RAB:GTP recruits GBF1 to the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10563535", "map_id": "none", "name": "RAB1:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "species_10563179", "map_id": "G5EGS5", "name": "gbf-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10563828", "map_id": "none", "name": "RAB1:GTP:GBF1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "reaction_10563890", "map_id": "none", "name": "NSF ATPase activity dissociates cis-SNARE at the ER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10563887", "map_id": "none", "name": "SEC22B:STX18:USE1:BNIP1L:3xSNAPs:NSF hexamer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q18921", "map_id": "Q18921", "name": "snap-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017016", "map_id": "WBGene00017016", "name": "snap-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q94392", "map_id": "Q94392", "name": "nsf-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003818", "map_id": "WBGene00003818", "name": "nsf-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q94241", "map_id": "Q94241", "name": "sec-22", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018853", "map_id": "WBGene00018853", "name": "sec-22", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "C0Z1Y7", "map_id": "C0Z1Y7", "name": "sec-20", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018239", "map_id": "WBGene00018239", "name": "sec-20", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O76413", "map_id": "O76413", "name": "syx-18", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020425", "map_id": "WBGene00020425", "name": "syx-18", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9N598", "map_id": "Q9N598", "name": "USE1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022460", "map_id": "WBGene00022460", "name": "USE1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10563883", "map_id": "Q9N598", "name": "USE1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10515624", "map_id": "Q94241", "name": "sec-22", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10563878", "map_id": "O76413", "name": "syx-18", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10557345", "map_id": "none", "name": "SNAPs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10557329", "map_id": "none", "name": "NSF hexamer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10563873", "map_id": "C0Z1Y7", "name": "sec-20", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "reaction_10563832", "map_id": "none", "name": "GBF1 recruits ARF:GDP to the Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10563191", "map_id": "none", "name": "ARF:GDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10563898", "map_id": "none", "name": "NSF and SNAPs bind cis-SNARE at the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10563896", "map_id": "none", "name": "SEC22B:STX18:USE1L:BNIP1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10563868", "map_id": "none", "name": "ARFGAPs stimulate ARF GTPase activity at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10563853", "map_id": "none", "name": "RAB1:GTP:GBF1:ARF:GTP:coatomer:p24 dimers:ARFGAPs:SEC22B:cargo", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "Q09473", "map_id": "Q09473", "name": "erd-2.2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016195", "map_id": "WBGene00016195", "name": "erd-2.2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P48583", "map_id": "P48583", "name": "erd-2.1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001331", "map_id": "WBGene00001331", "name": "erd-2.1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q18864", "map_id": "Q18864", "name": "sft-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004788", "map_id": "WBGene00004788", "name": "sft-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q20546", "map_id": "Q20546", "name": "tmed-10", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009829", "map_id": "WBGene00009829", "name": "tmed-10", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A4F319", "map_id": "A4F319", "name": "tmed-12", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011606", "map_id": "WBGene00011606", "name": "tmed-12", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9U1Z4", "map_id": "Q9U1Z4", "name": "tmed-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013360", "map_id": "WBGene00013360", "name": "tmed-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O17528", "map_id": "O17528", "name": "sel-9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004766", "map_id": "WBGene00004766", "name": "sel-9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O44738", "map_id": "O44738", "name": "tmed-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019003", "map_id": "WBGene00019003", "name": "tmed-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q09236", "map_id": "Q09236", "name": "copd-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00015734", "map_id": "WBGene00015734", "name": "copd-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q22498", "map_id": "Q22498", "name": "copg-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011775", "map_id": "WBGene00011775", "name": "copg-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9TYL9", "map_id": "Q9TYL9", "name": "copb-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021292", "map_id": "WBGene00021292", "name": "copb-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O17901", "map_id": "O17901", "name": "copz-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010333", "map_id": "WBGene00010333", "name": "copz-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q20168", "map_id": "Q20168", "name": "copb-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009542", "map_id": "WBGene00009542", "name": "copb-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O62246", "map_id": "O62246", "name": "cope-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009732", "map_id": "WBGene00009732", "name": "cope-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9N4H7", "map_id": "Q9N4H7", "name": "copa-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022119", "map_id": "WBGene00022119", "name": "copa-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q09531", "map_id": "Q09531", "name": "ARFGAP2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017217", "map_id": "WBGene00017217", "name": "ARFGAP2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P90904", "map_id": "P90904", "name": "ARFGAP1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010500", "map_id": "WBGene00010500", "name": "ARFGAP1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10563262", "map_id": "none", "name": "ARFGAP1,2,3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10563865", "map_id": "none", "name": "RAB1:GTP:coatomer:p24 dimers:SEC22B:cargo", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_432051", "compartment_display": "transport vesicle", "complex": "true" }, { "id": "reaction_10563855", "map_id": "none", "name": "ARFGAP, cargo, vSNARES and p24 proteins bind COPI vesicles at Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10563836", "map_id": "none", "name": "RAB1:GTP:GBF1:ARF:GTP:coatomer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "species_10563565", "map_id": "none", "name": "p24 dimers", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "species_10563851", "map_id": "none", "name": "Golgi-to-ER cargo", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "species_10563845", "map_id": "Q94241", "name": "sec-22", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "reaction_10563838", "map_id": "none", "name": "Active ARF recruits coatomer to the Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10563244", "map_id": "none", "name": "coatomer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10563982", "map_id": "none", "name": "COPI vesicle uncoating at the ER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10563980", "map_id": "none", "name": "RAB1:GTP:coatomer:p24 dimers:SEC22B:cargo:NBAS:RINT1:ZW10:STX18:USE1L:BNIP1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q19642", "map_id": "Q19642", "name": "czw-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017643", "map_id": "WBGene00017643", "name": "czw-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P90841", "map_id": "P90841", "name": "smgl-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008990", "map_id": "WBGene00008990", "name": "smgl-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10557214", "map_id": "none", "name": "RAB1:GDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10563978", "map_id": "none", "name": "Golgi-to-ER cargo", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "species_10563936", "map_id": "none", "name": "p24 dimers", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10555089", "map_id": "none", "name": "Dissociation of RAS:RAF complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10555069", "map_id": "none", "name": "activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10555030", "map_id": "none", "name": "RAF/MAPK scaffolds", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10555044", "map_id": "none", "name": "p21RAS:GTP:activated RAF1 homo/heterodimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10572917", "map_id": "none", "name": "Dual mechanism MAP2K inhibitors bind MAP2Ks", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_9657567", "map_id": "none", "name": "dual mechanism MAP2K1/2 inhibitors", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10555042", "map_id": "none", "name": "activated RAF:scaffold:MAP2K:MAPK complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10555074", "map_id": "none", "name": "activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors", "type": "inhibitor", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10555156", "map_id": "none", "name": "IL17RD binds p-2S MAP2Ks and MAPKs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10555152", "map_id": "none", "name": "Homologues of IL17RD", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "Q10128", "map_id": "Q10128", "name": "ilcr-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018960", "map_id": "WBGene00018960", "name": "ilcr-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9NA64", "map_id": "Q9NA64", "name": "ilcr-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013415", "map_id": "WBGene00013415", "name": "ilcr-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10555154", "map_id": "none", "name": "IL17RD:p-2S MAP2Ks:MAPKs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "reaction_10572919", "map_id": "none", "name": "Dual mechanism MAPK inhibitors bind MAPKs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10555067", "map_id": "none", "name": "activated RAF:scaffold:p-2S MAP2K:MAPK complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_9657570", "map_id": "none", "name": "dual mechanism MAPK inhibitors", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10555076", "map_id": "none", "name": "activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors", "type": "inhibitor", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10555078", "map_id": "none", "name": "MAP2Ks phosphorylate MAPKs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10555072", "map_id": "none", "name": "activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10572921", "map_id": "none", "name": "Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_9657574", "map_id": "none", "name": "single mechanism MAP2K1/2 inhibitors", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10555129", "map_id": "none", "name": "MAP2Ks and MAPKs are phosphorylated at the endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_74700", "compartment_display": "endosome membrane" }, { "id": "species_10555125", "map_id": "none", "name": "WDR83:LAMTOR2:LAMTOR3:activated RAF:MAP2K:MAPK complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "true" }, { "id": "Q19986", "map_id": "Q19986", "name": "wdr-83", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018014", "map_id": "WBGene00018014", "name": "wdr-83", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9N2U6", "map_id": "Q9N2U6", "name": "lmtr-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022402", "map_id": "WBGene00022402", "name": "lmtr-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8WQG5", "map_id": "Q8WQG5", "name": "lmtr-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007390", "map_id": "WBGene00007390", "name": "lmtr-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10555127", "map_id": "none", "name": "WDR83:LAMTOR2:LAMTOR3:activated RAF:p-2S MAP2K:p-T,Y MAPK complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "true" }, { "id": "reaction_10555161", "map_id": "none", "name": "MAP2Ks phosphorylate MAPK at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10555158", "map_id": "none", "name": "IL17RD:p-2S MAP2Ks:p-T,Y MAPKs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "reaction_10555131", "map_id": "none", "name": "WDR83:LAMTOR2:LAMTOR3 binds MAPK components", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_74700", "compartment_display": "endosome membrane" }, { "id": "species_10555123", "map_id": "none", "name": "activated RAF homo/heterodimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10555121", "map_id": "none", "name": "WDR83:LAMTOR2:LAMTOR3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "true" }, { "id": "reaction_10555053", "map_id": "none", "name": "MAP2Ks and MAPKs bind to the activated RAF complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10555006", "map_id": "none", "name": "p21 RAS:GTP:activated RAF homo/heterodimer complexes", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10555051", "map_id": "none", "name": "p21 RAS:GTP:activated RAF1 homo/heterodimer:PEBP1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "O16264", "map_id": "O16264", "name": "PEBP1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018218", "map_id": "WBGene00018218", "name": "PEBP1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10572925", "map_id": "none", "name": "Single mechanism MAPK inhibitors bind phosphorylated MAPK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_9657577", "map_id": "none", "name": "single mechanism MAPK inhibitors", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10572923", "map_id": "none", "name": "activated RAF:scaffold:p-2S MAP2K:p-2T MAPK:single mechanism MAPK inhibitors", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10555086", "map_id": "none", "name": "RAF phosphorylates MAP2K dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10555084", "map_id": "none", "name": "p21RAS:GTP:homo/heterodimerized RAF complex:RAF dimer inhibitors", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10534928", "map_id": "none", "name": "PG is hydrolyzed to 1-acyl LPG by PLA2[1]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_1483256", "map_id": "CHEBI:17517", "name": "PG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_1524021", "map_id": "CHEBI:57560", "name": "LCFA(-)", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_1498740", "map_id": "CHEBI:62747", "name": "1-acyl LPG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10534783", "map_id": "none", "name": "Homologues of PLA2G2F", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "O16654", "map_id": "O16654", "name": "PLA2G2A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00044468", "map_id": "WBGene00044468", "name": "PLA2G2A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q17790", "map_id": "Q17790", "name": "PLA2G2A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q3V5J7", "map_id": "Q3V5J7", "name": "PLA2G2A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10535857", "map_id": "none", "name": "PG is hydrolyzed to 1-acyl LPG by PLA2[16]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_1602402", "map_id": "CHEBI:17517", "name": "PG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_1602415", "map_id": "CHEBI:62747", "name": "1-acyl LPG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_1602366", "map_id": "CHEBI:57560", "name": "LCFA(-)", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10535837", "map_id": "none", "name": "PLA2(16)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "Q18339", "map_id": "Q18339", "name": "PLA2G12A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016288", "map_id": "WBGene00016288", "name": "PLA2G12A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10535855", "map_id": "none", "name": "Homologues of PLA2R1(21-?)", "type": "inhibitor", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "G4RY15", "map_id": "G4RY15", "name": "clec-89", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00015631", "map_id": "WBGene00015631", "name": "clec-89", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34472", "map_id": "P34472", "name": "clec-161", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010228", "map_id": "WBGene00010228", "name": "clec-161", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q22591", "map_id": "Q22591", "name": "clec-178", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020585", "map_id": "WBGene00020585", "name": "clec-178", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10534930", "map_id": "none", "name": "PG is hydrolyzed to 1-acyl LPG by PLA2G2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10534852", "map_id": "none", "name": "PLA2G2A:Ca2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10534742", "map_id": "none", "name": "1-acyl LPG is acylated to PG by LPGAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_1500578", "map_id": "CHEBI:17984", "name": "acyl-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10534739", "map_id": "A0A486WXW2", "name": "acl-14", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "WBGene00019465", "map_id": "WBGene00019465", "name": "acl-14", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10534792", "map_id": "none", "name": "2-acyl LPG is acylated to PG by LPGAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_1498730", "map_id": "CHEBI:27923", "name": "2-acyl LPG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "reaction_10534858", "map_id": "none", "name": "1-acyl LPG is acylated to PG by CRLS1 (IM)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane" }, { "id": "species_1524027", "map_id": "CHEBI:62747", "name": "1-acyl LPG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "species_1524038", "map_id": "CHEBI:17984", "name": "acyl-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_1524042", "map_id": "CHEBI:17517", "name": "PG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "species_10534747", "map_id": "O01916", "name": "crls-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "WBGene00017763", "map_id": "WBGene00017763", "name": "crls-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10534750", "map_id": "none", "name": "2-acyl LPG is acylated to PG by CRLS1 (IM)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane" }, { "id": "species_1524047", "map_id": "CHEBI:27923", "name": "2-acyl LPG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "reaction_10565132", "map_id": "none", "name": "RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10554985", "map_id": "none", "name": "HGF:p-4Y-MET dimer:GRB2-1:SOS1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10565135", "map_id": "none", "name": "RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10554983", "map_id": "none", "name": "HGF:p-4Y-MET dimer:RANBP9:SOS1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9XWK4", "map_id": "Q9XWK4", "name": "RANBP9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013202", "map_id": "WBGene00013202", "name": "RANBP9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10550976", "map_id": "none", "name": "CDK1 phosphorylates lamins and facilitates depolymerization of lamin filaments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10550899", "map_id": "none", "name": "p-S395-Lamin dimers", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q19782", "map_id": "Q19782", "name": "phospho-ifd-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002058", "map_id": "WBGene00002058", "name": "phospho-ifd-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P90900", "map_id": "P90900", "name": "phospho-ifa-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002052", "map_id": "WBGene00002052", "name": "phospho-ifa-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q21065", "map_id": "Q21065", "name": "phospho-ifa-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002051", "map_id": "WBGene00002051", "name": "phospho-ifa-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P90901", "map_id": "P90901", "name": "phospho-ifa-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002050", "map_id": "WBGene00002050", "name": "phospho-ifa-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q21067", "map_id": "Q21067", "name": "phospho-ifc-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002056", "map_id": "WBGene00002056", "name": "phospho-ifc-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q09501", "map_id": "Q09501", "name": "phospho-ifp-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002067", "map_id": "WBGene00002067", "name": "phospho-ifp-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q21443", "map_id": "Q21443", "name": "lmn-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003052", "map_id": "WBGene00003052", "name": "lmn-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q19286", "map_id": "Q19286", "name": "phospho-ifb-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002054", "map_id": "WBGene00002054", "name": "phospho-ifb-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O02365", "map_id": "O02365", "name": "phospho-mua-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003485", "map_id": "WBGene00003485", "name": "phospho-mua-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86DC6", "map_id": "Q86DC6", "name": "phospho-ifd-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002057", "map_id": "WBGene00002057", "name": "phospho-ifd-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q19289", "map_id": "Q19289", "name": "phospho-ifb-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002053", "map_id": "WBGene00002053", "name": "phospho-ifb-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O45168", "map_id": "O45168", "name": "phospho-ifc-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002055", "map_id": "WBGene00002055", "name": "phospho-ifc-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10550974", "map_id": "none", "name": "p-S22/23, S395-Lamin dimers", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10511241", "map_id": "none", "name": "CCNB1:p-T161-CDK1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "O45926", "map_id": "O45926", "name": "cyb-2.1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000866", "map_id": "WBGene00000866", "name": "cyb-2.1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q10653", "map_id": "Q10653", "name": "cyb-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000865", "map_id": "WBGene00000865", "name": "cyb-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9BLB5", "map_id": "Q9BLB5", "name": "cyb-2.2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000867", "map_id": "WBGene00000867", "name": "cyb-2.2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34556", "map_id": "P34556", "name": "phospho-cdk-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000405", "map_id": "WBGene00000405", "name": "phospho-cdk-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10550709", "map_id": "none", "name": "LPIN catalyzes conversion of phosphatidic acid to diacylglycerol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13231", "compartment_display": "nuclear envelope" }, { "id": "species_5221122", "map_id": "CHEBI:29089", "name": "1,2-diacyl-glycerol 3-phosphate", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_13231", "compartment_display": "nuclear envelope", "complex": "false" }, { "id": "species_5221124", "map_id": "CHEBI:17815", "name": "DAG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_13231", "compartment_display": "nuclear envelope", "complex": "false" }, { "id": "species_10549162", "map_id": "Q9XXT5", "name": "lpin-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_13231", "compartment_display": "nuclear envelope", "complex": "false" }, { "id": "WBGene00010425", "map_id": "WBGene00010425", "name": "lpin-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10550349", "map_id": "none", "name": "CDK1 phosphorylates LPIN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10549156", "map_id": "Q9XXT5", "name": "phospho-lpin-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10549181", "map_id": "none", "name": "CTDNEP1:CNEP1R1 dephosphorylates LPIN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13231", "compartment_display": "nuclear envelope" }, { "id": "species_10549178", "map_id": "none", "name": "CTDNEP1:CNEP1R1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_13231", "compartment_display": "nuclear envelope", "complex": "true" }, { "id": "Q20432", "map_id": "Q20432", "name": "cnep-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018474", "map_id": "WBGene00018474", "name": "cnep-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XXN3", "map_id": "Q9XXN3", "name": "nepr-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011828", "map_id": "WBGene00011828", "name": "nepr-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10550717", "map_id": "none", "name": "DAG and Ca+2 bind to PKC and tether it to membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13231", "compartment_display": "nuclear envelope" }, { "id": "species_29496", "map_id": "CHEBI:29108", "name": "Ca2+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10550711", "map_id": "P90980", "name": "phospho-pkc-2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10550715", "map_id": "none", "name": "DAG:active PKC:Ca+2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_13231", "compartment_display": "nuclear envelope", "complex": "true" }, { "id": "reaction_10520494", "map_id": "none", "name": "PTPRF, PTPRS, PTPRD bind Liprins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10520490", "map_id": "none", "name": "PTPRF, PTPRS, PTPRD", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "O01736", "map_id": "O01736", "name": "PTPRS", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00044348", "map_id": "WBGene00044348", "name": "PTPRS", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9BMN8", "map_id": "Q9BMN8", "name": "ptp-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004215", "map_id": "WBGene00004215", "name": "ptp-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O17889", "map_id": "O17889", "name": "PTPRS", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "W6RR46", "map_id": "W6RR46", "name": "PTPRS", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q22852", "map_id": "Q22852", "name": "PTPRS", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q95Y26", "map_id": "Q95Y26", "name": "PTPRS", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10520454", "map_id": "none", "name": "Liprins", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q21049", "map_id": "Q21049", "name": "syd-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006364", "map_id": "WBGene00006364", "name": "syd-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q94071", "map_id": "Q94071", "name": "hlb-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011904", "map_id": "WBGene00011904", "name": "hlb-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10520492", "map_id": "none", "name": "LAR,PTPRS,PTPRD:Liprins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10559201", "map_id": "none", "name": "NRXNs bind NLGNs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10559197", "map_id": "none", "name": "NLGN dimers", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q20826", "map_id": "Q20826", "name": "glit-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018878", "map_id": "WBGene00018878", "name": "glit-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XTG1", "map_id": "Q9XTG1", "name": "nlg-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006412", "map_id": "WBGene00006412", "name": "nlg-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10559159", "map_id": "none", "name": "NRXNs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "I2HAJ6", "map_id": "I2HAJ6", "name": "nrx-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007799", "map_id": "WBGene00007799", "name": "nrx-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O45000", "map_id": "O45000", "name": "itx-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002174", "map_id": "WBGene00002174", "name": "itx-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10559199", "map_id": "none", "name": "NRXNs:NLGN dimers", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10559280", "map_id": "none", "name": "ABP1 binds SHANK proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10515342", "map_id": "Q9XUT0", "name": "dbn-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00010664", "map_id": "WBGene00010664", "name": "dbn-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10559276", "map_id": "none", "name": "NRXNs:NLGN dimer:PSD-95:GKAP1-4:SHANK1,2,3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "B7WN72", "map_id": "B7WN72", "name": "shn-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006444", "map_id": "WBGene00006444", "name": "shn-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10559278", "map_id": "none", "name": "NRXNs:NLGN dimer:PSD-95:GKAP1-4:SHANK1,2,3:DBNL", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9XUT0", "map_id": "Q9XUT0", "name": "dbn-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10559284", "map_id": "none", "name": "NRXNs bind CASK:Protein 4.1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10559241", "map_id": "none", "name": "CASK:Protein 4.1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P54936", "map_id": "P54936", "name": "lin-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002991", "map_id": "WBGene00002991", "name": "lin-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "H2KZV9", "map_id": "H2KZV9", "name": "frm-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001489", "map_id": "WBGene00001489", "name": "frm-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EEG8", "map_id": "G5EEG8", "name": "frm-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001488", "map_id": "WBGene00001488", "name": "frm-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10559282", "map_id": "none", "name": "NRXNs:NLGN dimers:CASK:Protein 4.1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10559243", "map_id": "none", "name": "Protein 4.1 binds CASK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10559239", "map_id": "none", "name": "Protein 4.1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10519878", "map_id": "P54936", "name": "lin-2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10564964", "map_id": "none", "name": "PSD-95 binds NMDA receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10564960", "map_id": "none", "name": "NMDA receptor complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "G5EEH3", "map_id": "G5EEH3", "name": "phospho-nmr-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003775", "map_id": "WBGene00003775", "name": "phospho-nmr-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EGQ9", "map_id": "G5EGQ9", "name": "nmr-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003774", "map_id": "WBGene00003774", "name": "nmr-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10523840", "map_id": "none", "name": "Homologues of DLG4", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10564962", "map_id": "none", "name": "NMDAR:PSD-95", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10552287", "map_id": "none", "name": "55S ribosome with peptidyl-tRNA in A site binds GFM1:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10552283", "map_id": "none", "name": "GFM1:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q9XV52", "map_id": "Q9XV52", "name": "gfm-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009246", "map_id": "WBGene00009246", "name": "gfm-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10552276", "map_id": "none", "name": "55S ribosome:mRNA:tRNA:peptidyl-tRNA at A-site", "type": "reactant", "sub_type": "complex_component", "inferred": 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_33625", "map_id": "CHEBI:18303", "name": "PS", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_1602419", "map_id": "CHEBI:52603", "name": "1-acyl LPS", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10534870", "map_id": "none", "name": "PS is hydrolyzed to 1-acyl LPS by PLA2G2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_1500646", "map_id": "CHEBI:18303", "name": "PS", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_1498724", "map_id": "CHEBI:52603", "name": "1-acyl LPS", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "reaction_10534806", "map_id": "none", "name": "1-acyl LPS is acylated to PS by LPSAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10534803", "map_id": "none", "name": "LPSAT", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "G5EC53", "map_id": "G5EC53", "name": "mboa-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016934", "map_id": "WBGene00016934", "name": "mboa-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "H9G2W5", "map_id": "H9G2W5", "name": "mboa-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007446", "map_id": "WBGene00007446", "name": "mboa-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O01925", "map_id": "O01925", "name": "mboa-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020115", "map_id": "WBGene00020115", "name": "mboa-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10566472", "map_id": "none", "name": "OSBPL5,8,10 exchange PS with PI4P from ER membrane to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_392417", "map_id": "CHEBI:17526", "name": "PI4P", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_1806234", "map_id": "CHEBI:17526", "name": "PI4P", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10566469", "map_id": "Q8MPR9", "name": "obr-3", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00014215", "map_id": "WBGene00014215", "name": "obr-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10534861", "map_id": "none", "name": "2-acyl LPS is acylated to PS by LPSAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_1498722", "map_id": "CHEBI:37646", "name": "2-acyl LPS", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "reaction_10570607", "map_id": "none", "name": "PITRM1 proteolyzes mitochondrial targeting peptides (presequences)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10570599", "map_id": "none", "name": "Mitochondrial targeting peptides (from inner membrane proteins)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q9XWJ5", "map_id": "Q9XWJ5", "name": "NDUFB8(1-28)", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013094", "map_id": "WBGene00013094", "name": "NDUFB8(1-28)", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10570604", "map_id": "Q22370", "name": "ucr-2.2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "WBGene00011679", "map_id": "WBGene00011679", "name": "ucr-2.2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10529207", "map_id": "none", "name": "SLC46A1 transports hemes from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_9707310", "map_id": "none", "name": "Hemes", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_71185", "map_id": "CHEBI:17627", "name": "heme", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_9707308", "map_id": "none", "name": "Hemes", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10514650", "map_id": "none", "name": "Homologues of SLC46A1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9UAZ6", "map_id": "Q9UAZ6", "name": "slc-46a", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021159", "map_id": "WBGene00021159", "name": "slc-46a", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XWL3", "map_id": "Q9XWL3", "name": "slcr-46.2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012811", "map_id": "WBGene00012811", "name": "slcr-46.2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "H2KZC0", "map_id": "H2KZC0", "name": "slcr-46.1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016705", "map_id": "WBGene00016705", "name": "slcr-46.1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q20236", "map_id": "Q20236", "name": "slcr-46.3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009582", "map_id": "WBGene00009582", "name": "slcr-46.3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10532366", "map_id": "none", "name": "Activation of p38 MAPK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10532355", "map_id": "none", "name": "p38 MAPK", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10532363", "map_id": "none", "name": "Phospho-p38 MAPK", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10525519", "map_id": "G5EDF7", "name": "phospho-sek-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10532487", "map_id": "none", "name": "TXNIP binds reduced thioredoxin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10532483", "map_id": "none", "name": "Homologues of TXNIP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P91469", "map_id": "P91469", "name": "arrd-22", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020612", "map_id": "WBGene00020612", "name": "arrd-22", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XXN6", "map_id": "Q9XXN6", "name": "arrd-28", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", 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"none" }, { "id": "Q9XTU0", "map_id": "Q9XTU0", "name": "arrd-16", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013043", "map_id": "WBGene00013043", "name": "arrd-16", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q22321", "map_id": "Q22321", "name": "arrd-23", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020323", "map_id": "WBGene00020323", "name": "arrd-23", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O45782", "map_id": "O45782", "name": "arrd-17", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": 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"Q23672", "name": "arrd-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00014159", "map_id": "WBGene00014159", "name": "arrd-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O62274", "map_id": "O62274", "name": "arrd-10", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010268", "map_id": "WBGene00010268", "name": "arrd-10", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XXI0", "map_id": "Q9XXI0", "name": "arrd-8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012467", "map_id": "WBGene00012467", "name": "arrd-8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O17812", "map_id": "O17812", "name": "arrd-9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008843", "map_id": "WBGene00008843", "name": "arrd-9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q23674", "map_id": "Q23674", "name": "arrd-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00014161", "map_id": "WBGene00014161", "name": "arrd-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P30647", "map_id": "P30647", "name": "arrd-15", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00014033", "map_id": "WBGene00014033", "name": "arrd-15", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XXI4", "map_id": "Q9XXI4", "name": "arrd-7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012464", "map_id": "WBGene00012464", "name": "arrd-7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O17981", "map_id": "O17981", "name": "arrd-11", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011052", "map_id": "WBGene00011052", "name": "arrd-11", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9GYT4", "map_id": "Q9GYT4", "name": "arrd-19", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018061", "map_id": "WBGene00018061", "name": "arrd-19", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10506160", "map_id": "Q09433", "name": "trx-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00015062", "map_id": "WBGene00015062", "name": "trx-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10532485", "map_id": "none", "name": "Thioredoxin:TXNIP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q09433", "map_id": "Q09433", "name": "trx-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10532489", "map_id": "none", "name": "ROS oxidize thioredoxin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1250243", "map_id": "CHEBI:26523", "name": "ROS", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10506158", "map_id": "Q09433", "name": "trx-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10571508", "map_id": "none", "name": "PRKCI phosphorylates ELF3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10571503", "map_id": "G5EC57", "name": "svh-5", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00006462", "map_id": "WBGene00006462", "name": "svh-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10571505", "map_id": "Q19266", "name": "pkc-3", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00004034", "map_id": "WBGene00004034", "name": "phospho-pkc-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10538172", "map_id": "none", "name": "Mature NOTCH heterodimer traffics to the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10538156", "map_id": "none", "name": "NOTCH4", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "Q21850", "map_id": "Q21850", "name": "phospho-p-4S-NICD4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019957", "map_id": "WBGene00019957", "name": "phospho-p-4S-NICD4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10538165", "map_id": "none", "name": "NOTCH4", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10538170", "map_id": "O17528", "name": "sel-9", "type": "inhibitor", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_6791047", "compartment_display": "endoplasmic reticulum-Golgi intermediate compartment membrane", "complex": "false" }, { "id": "reaction_10532496", "map_id": "none", "name": "Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10532493", "map_id": "none", "name": "PI3K:p-ERBB4cyt1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10532624", "map_id": "none", "name": "WWOX binds ERBB4s80", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10532620", "map_id": "Q19062", "name": "dhs-7", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00000971", "map_id": "WBGene00000971", "name": "dhs-7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10532532", "map_id": "none", "name": "ERBB4s80", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P24348", "map_id": "P24348", "name": "let-23", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002299", "map_id": "WBGene00002299", "name": "let-23", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10532622", "map_id": "none", "name": "ERBB4s80:WWOX", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q19062", "map_id": "Q19062", "name": "dhs-7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10532677", "map_id": "none", "name": "Translocation of cytosolic ERBB4s80 to mitochondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10532675", "map_id": "none", "name": "ERBB4s80", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "reaction_10532663", "map_id": "none", "name": "ERBB4s80:STAT5A complex translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10532651", "map_id": "none", "name": "ERBB4s80:p-Y694-STAT5A", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10532661", "map_id": "none", "name": "ERBB4s80:p-Y694-STAT5A", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10532665", "map_id": "none", "name": "ERBB4s80 binds STAT5A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10532649", "map_id": "none", "name": "p-Y694-STAT5A homodimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10532603", "map_id": "none", "name": "Translocation of ERBB4s80 to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10532599", "map_id": "none", "name": "ERBB4s80", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10532601", "map_id": "none", "name": "ERBB4s80:MyrG-p-Y419-SRC", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10532589", "map_id": "none", "name": "Cleavage of ERBB4m80 by gamma-scretase complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10532522", "map_id": "none", "name": "ERBB4m80", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10532586", "map_id": "none", "name": "gamma-secretase complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q23316", "map_id": "Q23316", "name": "aph-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000148", "map_id": "WBGene00000148", "name": "aph-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P52166", "map_id": "P52166", "name": "sel-12", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004769", "map_id": "WBGene00004769", "name": "sel-12", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q01608", "map_id": "Q01608", "name": "spe-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004958", "map_id": "WBGene00004958", "name": "spe-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O02100", "map_id": "O02100", "name": "hop-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001985", "map_id": "WBGene00001985", "name": "hop-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9U357", "map_id": "Q9U357", "name": "pen-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003975", "map_id": "WBGene00003975", "name": "pen-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O45876", "map_id": "O45876", "name": "aph-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000147", "map_id": "WBGene00000147", "name": "aph-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10532637", "map_id": "none", "name": "Translocation of ERBB4s80:YAP1 complex to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10532631", "map_id": "none", "name": "ERBB4s80:YAP1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q19404", "map_id": "Q19404", "name": "yap-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008748", "map_id": "WBGene00008748", "name": "yap-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10532635", "map_id": "none", "name": "ERBB4s80:YAP1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10532639", "map_id": "none", "name": "ERBB4s80 binds YAP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10532629", "map_id": "Q19404", "name": "yap-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10538338", "map_id": "none", "name": "NEDD4 ubiquitinates ERBB4jmAcyt1s80 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10538331", "map_id": "none", "name": "ERBB4jmAcyt1s80:NEDD4", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10538335", "map_id": "none", "name": "Ub-ERBB4jmAcyt1s80:NEDD4", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10532613", "map_id": "none", "name": "ERBB4 ubiquitination by WWP1/ITCH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10532608", "map_id": "none", "name": "ERBB4/m80/s80:WWP1/ITCH", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10532610", "map_id": "none", "name": "Ub-ERBB4:WWP1/ITCH", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10532615", "map_id": "none", "name": "ERBB4 binds WWP1/ITCH ubiquitin ligases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10532606", "map_id": "none", "name": "ERBB4/ERBB4m80/ERBB4s80", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10530908", "map_id": "Q9N2Z7", "name": "wwp-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10572102", "map_id": "none", "name": "ERBB4s80 binds to SRC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10518187", "map_id": "none", "name": "Homologues of MyrG-p-Y419-SRC", "type": "inhibitor", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10538333", "map_id": "none", "name": "NEDD4 binds ERBB4jmAcyt1s80 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10532526", "map_id": "none", "name": "ERBB4jmAcyt1s80 dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10509830", "map_id": "none", "name": "Inactivation of APC/C via CDC20 sequestration", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10509819", "map_id": "Q09373", "name": "fzy-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00001511", "map_id": "WBGene00001511", "name": "fzy-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10509824", "map_id": "Q9NGT3", "name": "mdf-2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00003161", "map_id": "WBGene00003161", "name": "mdf-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10509828", "map_id": "none", "name": "MAD2*CDC20 complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9NGT3", "map_id": "Q9NGT3", "name": "mdf-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q09373", "map_id": "Q09373", "name": "fzy-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10509832", "map_id": "none", "name": "Formation of the MCC complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10509814", "map_id": "Q9XWH0", "name": "bub-3", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00013209", "map_id": "WBGene00013209", "name": "bub-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10509809", "map_id": "Q21776", "name": "bub-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00000275", "map_id": "WBGene00000275", "name": "bub-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10509826", "map_id": "none", "name": "hBUBR1:hBUB3:MAD2*:CDC20 complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q21776", "map_id": "Q21776", "name": "bub-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XWH0", "map_id": "Q9XWH0", "name": "bub-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10511637", "map_id": "none", "name": "Phosphorylation of Cdh1 by Cyclin B1:Cdc2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10511632", "map_id": "Q09649", "name": "fzr-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00001510", "map_id": "WBGene00001510", "name": "fzr-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10511634", "map_id": "Q09649", "name": "phospho-fzr-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10522739", "map_id": "none", "name": "DAG kinase produces phosphatidic acid from DAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_76108", "map_id": "CHEBI:29089", "name": "1,2-daG3P", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10522736", "map_id": "none", "name": "Diacylglycerol kinase", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q03603", "map_id": "Q03603", "name": "dgk-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000960", "map_id": "WBGene00000960", "name": "dgk-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q10024", "map_id": "Q10024", "name": "dgk-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019428", "map_id": "WBGene00019428", "name": "dgk-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "H2KZC9", "map_id": "H2KZC9", "name": "dgk-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006483", "map_id": "WBGene00006483", "name": "dgk-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "H2KYI9", "map_id": "H2KYI9", "name": "dgk-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000959", "map_id": "WBGene00000959", "name": "dgk-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q17860", "map_id": "Q17860", "name": "dgk-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000958", "map_id": "WBGene00000958", "name": "dgk-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10509684", "map_id": "none", "name": "IP3R tetramer:I(1,4,5)P3:4xCa2+ transports Ca2+ from platelet dense tubular system to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_114521", "compartment_display": "platelet dense tubular network membrane" }, { "id": "species_139827", "map_id": "CHEBI:29108", "name": "Ca2+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_114580", "compartment_display": "platelet dense tubular network lumen", "complex": "false" }, { "id": "species_10509681", "map_id": "none", "name": "IP3R tetramer:I(1,4,5)P3:4xCa2+", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_114521", "compartment_display": "platelet dense tubular network membrane", "complex": "true" }, { "id": "species_114520", "map_id": "CHEBI:16595", "name": "I(1,4,5)P3", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "Q9Y0A1", "map_id": "Q9Y0A1", "name": "itr-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002173", "map_id": "WBGene00002173", "name": "itr-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10522615", "map_id": "none", "name": "DAG is metabolized by DAGL to 2-AG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_426026", "map_id": "CHEBI:35366", "name": "Fatty Acid", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_426030", "map_id": "CHEBI:52392", "name": "2AG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10522612", "map_id": "H2KY93", "name": "dagl-2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "WBGene00018364", "map_id": "WBGene00018364", "name": "dagl-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10557468", "map_id": "none", "name": "ABHD6,12 hydrolyse 3AG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_5694509", "map_id": "CHEBI:75571", "name": "3AG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_422506", "map_id": "CHEBI:15843", "name": "AA", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_76116", "map_id": "CHEBI:17754", "name": "Glycerol", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10557465", "map_id": "Q965S2", "name": "abhd-12", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "WBGene00022393", "map_id": "WBGene00022393", "name": "abhd-12", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10509686", "map_id": "none", "name": "Binding of IP3 to IP3 receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10509679", "map_id": "none", "name": "IP3R tetramer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_114521", "compartment_display": "platelet dense tubular network membrane", "complex": "true" }, { "id": "reaction_10522696", "map_id": "none", "name": "DAG activation of TRPC channels", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10522688", "map_id": "Q8I6Y9", "name": "trp-2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "WBGene00006615", "map_id": "WBGene00006615", "name": "trp-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10522694", "map_id": "none", "name": "DAG-activated TRPC3/6/7", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q8I6Y9", "map_id": "Q8I6Y9", "name": "trp-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10522510", "map_id": "none", "name": "Activation of Protein Kinase C novel isoforms", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10513858", "map_id": "none", "name": "PKC-delta/epsilon", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P34885", "map_id": "P34885", "name": "pkc-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004032", "map_id": "WBGene00004032", "name": "pkc-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34722", "map_id": "P34722", "name": "phospho-tpa-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006599", "map_id": "WBGene00006599", "name": "phospho-tpa-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10522508", "map_id": "none", "name": "Protein kinase C, novel isoforms:DAG", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10506679", "map_id": "none", "name": "uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_83962", "map_id": "CHEBI:17568", "name": "Ura", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_500244", "map_id": "none", "name": "R1P, dRibP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:28542", "map_id": "CHEBI:28542", "name": "CHEBI:28542", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_112016", "map_id": "CHEBI:35425", "name": "R1P", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_500430", "map_id": "none", "name": "(d)Ura", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:16450", "map_id": "CHEBI:16450", "name": "CHEBI:16450", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:16704", "map_id": "CHEBI:16704", "name": "CHEBI:16704", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10506676", "map_id": "none", "name": "UPP1, UPP2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q23588", "map_id": "Q23588", "name": "upp-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022817", "map_id": "WBGene00022817", "name": "upp-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10508615", "map_id": "none", "name": "cytidine or uridine + ATP => CMP or UMP + ADP [UCK2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_500759", "map_id": "none", "name": "Cyt-Rib, Ura-Rib", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:17562", "map_id": "CHEBI:17562", "name": "CHEBI:17562", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_500761", "map_id": "none", "name": "CMP, UMP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_109395", "map_id": "CHEBI:17361", "name": "CMP", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10508612", "map_id": "none", "name": "UCK2 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q17413", "map_id": "Q17413", "name": "UCK 2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007089", "map_id": "WBGene00007089", "name": "UCK 2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10558281", "map_id": "none", "name": "HDHD1:Mg2+ dephosphorylates PURIDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_6788291", "map_id": "CHEBI:18116", "name": "PURIDP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_6788290", "map_id": "CHEBI:17802", "name": "PURID", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10558278", "map_id": "none", "name": "HDHD1:Mg2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "G5EG26", "map_id": "G5EG26", "name": "R151.8A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020113", "map_id": "WBGene00020113", "name": "R151.8A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10506106", "map_id": "none", "name": "cytidine or uridine + ATP => CMP or UMP + ADP [UCK1]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10506103", "map_id": "none", "name": "UCK1 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10569948", "map_id": "none", "name": "UCKL1 phosphorylates urindine, cytidine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10569945", "map_id": "H2L2A8", "name": "UCKL1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00008948", "map_id": "WBGene00008948", "name": "UCKL1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10506142", "map_id": "none", "name": "thymidine + ATP => TMP (deoxythymidine 5'-monophosphate) + ADP [TK1]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_83928", "map_id": "CHEBI:17748", "name": "Thy-dRib", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_109366", "map_id": "CHEBI:17013", "name": "TMP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10506139", "map_id": "none", "name": "TK1 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "G5EEZ5", "map_id": "G5EEZ5", "name": "thk-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006568", "map_id": "WBGene00006568", "name": "thk-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10506126", "map_id": "none", "name": "(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_500829", "map_id": "none", "name": "Cyt-Rib, dC", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:15698", "map_id": "CHEBI:15698", "name": "CHEBI:15698", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10506123", "map_id": "none", "name": "CDA tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q20628", "map_id": "Q20628", "name": "cdd-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000392", "map_id": "WBGene00000392", "name": "cdd-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10509057", "map_id": "none", "name": "GRK2 binds CALM1:4Ca2+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10509037", "map_id": "Q09639", "name": "grk-2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "WBGene00001709", "map_id": "WBGene00001709", "name": "phospho-grk-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10508995", "map_id": "none", "name": "CALM1:4xCa2+", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10509039", "map_id": "none", "name": "GRK2:CALM1:4xCa2+", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q09639", "map_id": "Q09639", "name": "phospho-grk-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10509055", "map_id": "none", "name": "active PKC (alpha, gamma, delta)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10508962", "map_id": "none", "name": "cAMP induces dissociation of inactive PKA tetramers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10508958", "map_id": "none", "name": "PKA tetramer:4xcAMP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10508954", "map_id": "P21137", "name": "kin-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10508960", "map_id": "none", "name": "cAMP:PKA regulatory subunit", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10508997", "map_id": "none", "name": "Adenylate cyclase produces cAMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10508992", "map_id": "none", "name": "Adenylate cyclase (Mg2+ cofactor)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q19523", "map_id": "Q19523", "name": "acy-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000068", "map_id": "WBGene00000068", "name": "acy-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O16880", "map_id": "O16880", "name": "acy-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000069", "map_id": "WBGene00000069", "name": "acy-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EE33", "map_id": "G5EE33", "name": "acy-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000070", "map_id": "WBGene00000070", "name": "acy-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q966F9", "map_id": "Q966F9", "name": "acy-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000071", "map_id": "WBGene00000071", "name": "acy-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10569054", "map_id": "none", "name": "cAMP binds PKA tetramer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10508956", "map_id": "none", "name": "PKA tetramer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10509064", "map_id": "none", "name": "PKC phosphorylates GRK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10509061", "map_id": "Q09639", "name": "phospho-grk-2", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10524537", "map_id": "none", "name": "CaMKK autophosphorylates in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10524529", "map_id": "none", "name": "CaMKK:CALM1:4xCa2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q3Y416", "map_id": "Q3Y416", "name": "phospho-ckk-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000518", "map_id": "WBGene00000518", "name": "phospho-ckk-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10524534", "map_id": "none", "name": "p-CaMKK:CALM1:4xCa2+", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10509018", "map_id": "none", "name": "cAMP hydrolysis by Cam-PDE 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10509015", "map_id": "none", "name": "activated PDE1 dimers", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "O18696", "map_id": "O18696", "name": "pde-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011433", "map_id": "WBGene00011433", "name": "pde-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10509020", "map_id": "none", "name": "Calmodulin activates Cam-PDE 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10562897", "map_id": "none", "name": "RABGGTA binds RABGGTB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10562893", "map_id": "P41992", "name": "ggtb-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "WBGene00015099", "map_id": "WBGene00015099", "name": "ggtb-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10562888", "map_id": "Q9TYY0", "name": "RABGGTA", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "WBGene00019778", "map_id": "WBGene00019778", "name": "RABGGTA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10562895", "map_id": "none", "name": "RGGT", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9TYY0", "map_id": "Q9TYY0", "name": "RABGGTA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P41992", "map_id": "P41992", "name": "ggtb-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10562906", "map_id": "none", "name": "CHM binds RGGT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10562902", "map_id": "Q9BKQ5", "name": "rep-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00022051", "map_id": "WBGene00022051", "name": "rep-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10562904", "map_id": "none", "name": "RGGT:CHM", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9BKQ5", "map_id": "Q9BKQ5", "name": "rep-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10562850", "map_id": "none", "name": "PIDD1 translocates to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10562842", "map_id": "none", "name": "Homologues of p-T788-PIDD1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q09564", "map_id": "Q09564", "name": "phospho-phlp-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009647", "map_id": "WBGene00009647", "name": "phospho-phlp-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q17989", "map_id": "Q17989", "name": "phospho-lrch-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00015779", "map_id": "WBGene00015779", "name": "phospho-lrch-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10562848", "map_id": "none", "name": "Homologues of p-T788-PIDD1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10563082", "map_id": "none", "name": "CK2 binds FACT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10563078", "map_id": "none", "name": "Casein kinase II", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10509283", "map_id": "none", "name": "FACT complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9N5R9", "map_id": "Q9N5R9", "name": "spt-16", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018849", "map_id": "WBGene00018849", "name": "spt-16", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P41848", "map_id": "P41848", "name": "hmg-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001974", "map_id": "WBGene00001974", "name": "hmg-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10563080", "map_id": "none", "name": "CK2:FACT", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10567715", "map_id": "none", "name": "PIN1 binds phosphorylated PIP4K2B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10567708", "map_id": "none", "name": "p-S326-PIP4K2B dimers", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10529334", "map_id": "Q9N492", "name": "pinn-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00022448", "map_id": "WBGene00022448", "name": "pinn-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10567713", "map_id": "none", "name": "p-S326-PIP4K2B dimers:PIN1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9N492", "map_id": "Q9N492", "name": "pinn-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10567711", "map_id": "none", "name": "MAP2K6 phosphorylates PIP4K2B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10567697", "map_id": "none", "name": "PIP4K2B dimers", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10525531", "map_id": "G5EDF7", "name": "phospho-sek-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10559206", "map_id": "none", "name": "TORC2 complex phosphorylates SGK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10545420", "map_id": "Q2PJ68", "name": "sgk-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10559204", "map_id": "Q2PJ68", "name": "phospho-sgk-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10513953", "map_id": "none", "name": "TORC2 complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P91040", "map_id": "P91040", "name": "mlst-8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00015697", "map_id": "WBGene00015697", "name": "mlst-8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q95Q95", "map_id": "Q95Q95", "name": "let-363", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002583", "map_id": "WBGene00002583", "name": "let-363", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EFN2", "map_id": "G5EFN2", "name": "rict-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009245", "map_id": "WBGene00009245", "name": "rict-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9NA80", "map_id": "Q9NA80", "name": "sinh-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013261", "map_id": "WBGene00013261", "name": "sinh-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10559211", "map_id": "none", "name": "PDPK1 phosphorylates SGK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10559209", "map_id": "Q2PJ68", "name": "phospho-sgk-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10508530", "map_id": "none", "name": "PDPK1:PIP3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9UA62", "map_id": "Q9UA62", "name": "PDPK1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021022", "map_id": "WBGene00021022", "name": "PDPK1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10559312", "map_id": "none", "name": "CCNK:CDK12 binds RNA Pol II at DNA repair genes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10559292", "map_id": "none", "name": "Elongation Complex at DNA Repair Genes", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9N554", "map_id": "Q9N554", "name": "ell-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021281", "map_id": "WBGene00021281", "name": "ell-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "H2KYV0", "map_id": "H2KYV0", "name": "mdt-26", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016115", "map_id": "WBGene00016115", "name": "mdt-26", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P52652", "map_id": "P52652", "name": "TCEA1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012000", "map_id": "WBGene00012000", "name": "TCEA1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q09413", "map_id": "Q09413", "name": "tceb-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010990", "map_id": "WBGene00010990", "name": "tceb-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9BKS1", "map_id": "Q9BKS1", "name": "elc-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001236", "map_id": "WBGene00001236", "name": "elc-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5ECR7", "map_id": "G5ECR7", "name": "elb-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001235", "map_id": "WBGene00001235", "name": "elb-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9TVL3", "map_id": "Q9TVL3", "name": "cdk-9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000410", "map_id": "WBGene00000410", "name": "cdk-9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34424", "map_id": "P34424", "name": "cit-1.2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000508", "map_id": "WBGene00000508", "name": "cit-1.2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34425", "map_id": "P34425", "name": "cit-1.1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000507", "map_id": "WBGene00000507", "name": "cit-1.1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O17869", "map_id": "O17869", "name": "ccnk-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009650", "map_id": "WBGene00009650", "name": "ccnk-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9TZ93", "map_id": "Q9TZ93", "name": "spt-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00005014", "map_id": "WBGene00005014", "name": "spt-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q21338", "map_id": "Q21338", "name": "phospho-spt-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00005015", "map_id": "WBGene00005015", "name": "phospho-spt-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XUM4", "map_id": "Q9XUM4", "name": "CTDP1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012236", "map_id": "WBGene00012236", "name": "CTDP1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9N3L2", "map_id": "Q9N3L2", "name": "xpd-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021752", "map_id": "WBGene00021752", "name": "xpd-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34567", "map_id": "P34567", "name": "gtf-2H2C", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011814", "map_id": "WBGene00011814", "name": "gtf-2H2C", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9N390", "map_id": "Q9N390", "name": "gtf-2h5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021904", "map_id": "WBGene00021904", "name": "gtf-2h5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9N4U0", "map_id": "Q9N4U0", "name": "cyh-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021714", "map_id": "WBGene00021714", "name": "cyh-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O17245", "map_id": "O17245", "name": "mnat-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018769", "map_id": "WBGene00018769", "name": "mnat-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EFV5", "map_id": "G5EFV5", "name": "cdk-7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000408", "map_id": "WBGene00000408", "name": "cdk-7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q09645", "map_id": "Q09645", "name": "gtf-2h3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00014230", "map_id": "WBGene00014230", "name": "gtf-2h3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O44499", "map_id": "O44499", "name": "gtf-2h1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019821", "map_id": "WBGene00019821", "name": "gtf-2h1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q95PZ4", "map_id": "Q95PZ4", "name": "xpb-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013441", "map_id": "WBGene00013441", "name": "xpb-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "K8F7X5", "map_id": "K8F7X5", "name": "GTF2H4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013529", "map_id": "WBGene00013529", "name": "GTF2H4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10559218", "map_id": "none", "name": "CCNK:CDK12", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "P46551", "map_id": "P46551", "name": "cdk-12", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007135", "map_id": "WBGene00007135", "name": "cdk-12", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10559294", "map_id": "none", "name": "CCNK:CDK12:Elongation Complex at DNA Repair Genes", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10559220", "map_id": "none", "name": "CCNK binds CDK12", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10509199", "map_id": "O17869", "name": "ccnk-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10559216", "map_id": "P46551", "name": "cdk-12", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10559226", "map_id": "none", "name": "CCNK binds CDK13", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10559222", "map_id": "P46551", "name": "cdk-12", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10559224", "map_id": "none", "name": "CCNK:CDK13", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10559310", "map_id": "none", "name": "CDK12 phosphorylates RNA Pol II CTD at DNA repair genes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10559307", "map_id": "none", "name": "CCNK:CDK12:CDK12-Phosphorylated Elongation Complex at DNA repair genes", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10547457", "map_id": "none", "name": "PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29408", "map_id": "CHEBI:16240", "name": "H2O2", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10547454", "map_id": "none", "name": "PRDX1,2,5", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "A0A0K3AUJ9", "map_id": "A0A0K3AUJ9", "name": "prdx-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "F09E5.15c", "map_id": "F09E5.15c", "name": "prdx-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10503060", "map_id": "none", "name": "D-fructose 6-phosphate <=> alpha-D-Glucose 6-phosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29512", "map_id": "CHEBI:57634", "name": "Fru(6)P", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_30537", "map_id": "CHEBI:58225", "name": "G6P", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10503055", "map_id": "none", "name": "GPI dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q7K707", "map_id": "Q7K707", "name": "gpi-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013597", "map_id": "WBGene00013597", "name": "gpi-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10504231", "map_id": "none", "name": "glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10504228", "map_id": "none", "name": "GSR-2:FAD dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q93379", "map_id": "Q93379", "name": "gsr-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008117", "map_id": "WBGene00008117", "name": "gsr-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10502920", "map_id": "none", "name": "alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_31467", "map_id": "CHEBI:16938", "name": "D-Glucono-1,5-lactone 6-phosphate", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10502917", "map_id": "none", "name": "G6PD dimer and tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q27464", "map_id": "Q27464", "name": "gspd-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007108", "map_id": "WBGene00007108", "name": "gspd-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10506170", "map_id": "none", "name": "thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10506167", "map_id": "none", "name": "TNXRD1:FAD dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q17745", "map_id": "Q17745", "name": "trxr-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00015553", "map_id": "WBGene00015553", "name": "trxr-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10553994", "map_id": "none", "name": "SESN1,2,3 bind overoxidized PRDX1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10553978", "map_id": "none", "name": "HOOS-C52-PRDX1 dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10553986", "map_id": "Q9N4D6", "name": "sesn-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00022279", "map_id": "WBGene00022279", "name": "sesn-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10553992", "map_id": "none", "name": "SESN1,2,3:HOOS-C52-PRDX1 dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9N4D6", "map_id": "Q9N4D6", "name": "sesn-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10553981", "map_id": "none", "name": "PRDX1 overoxidizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10547448", "map_id": "none", "name": "PRDX1 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10519966", "map_id": "none", "name": "RHEB in mTORC1:RHEB:GTP hydrolyses GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10510588", "map_id": "none", "name": "Active mTORC1 complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "Q19425", "map_id": "Q19425", "name": "SLC38A9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008774", "map_id": "WBGene00008774", "name": "SLC38A9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EGB3", "map_id": "G5EGB3", "name": "ragc-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012497", "map_id": "WBGene00012497", "name": "ragc-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O17268", "map_id": "O17268", "name": "lmtr-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020101", "map_id": "WBGene00020101", "name": "lmtr-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q68TI8", "map_id": "Q68TI8", "name": "daf-15", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000911", "map_id": "WBGene00000911", "name": "daf-15", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34443", "map_id": "P34443", "name": "rheb-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010038", "map_id": "WBGene00010038", "name": "rheb-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10519963", "map_id": "none", "name": "mTORC1:Ragulator:Rag:GNP:RHEB:GDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "reaction_10553998", "map_id": "none", "name": "SESN1,2,3 bind AMPK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10519954", "map_id": "none", "name": "p-AMPK heterotrimer:AMP", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9XUY2", "map_id": "Q9XUY2", "name": "aakb-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010115", "map_id": "WBGene00010115", "name": "aakb-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P45894", "map_id": "P45894", "name": "phospho-aak-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019801", "map_id": "WBGene00019801", "name": "phospho-aak-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q95ZQ4", "map_id": "Q95ZQ4", "name": "phospho-aak-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020142", "map_id": "WBGene00020142", "name": "phospho-aak-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A1T5HUK9", "map_id": "A0A1T5HUK9", "name": "aakg-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013732", "map_id": "WBGene00013732", "name": "aakg-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "H2L0K0", "map_id": "H2L0K0", "name": "aakg-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020135", "map_id": "WBGene00020135", "name": "aakg-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O02168", "map_id": "O02168", "name": "aakg-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020633", "map_id": "WBGene00020633", "name": "aakg-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9N501", "map_id": "Q9N501", "name": "aakg-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021527", "map_id": "WBGene00021527", "name": "aakg-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10553996", "map_id": "none", "name": "SESN1,2,3:p-AMPK heterotrimer:AMP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10503263", "map_id": "none", "name": "glutamine + H2O => glutamate + NH4+ [GLS]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_113522", "map_id": "CHEBI:58359", "name": "L-Gln", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_113561", "map_id": "CHEBI:28938", "name": "NH4+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10503260", "map_id": "none", "name": "GLS dimers", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "U4PRW7", "map_id": "U4PRW7", "name": "glna-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007480", "map_id": "WBGene00007480", "name": "glna-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q19013", "map_id": "Q19013", "name": "glna-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008435", "map_id": "WBGene00008435", "name": "glna-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q93650", "map_id": "Q93650", "name": "glna-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009271", "map_id": "WBGene00009271", "name": "glna-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10563027", "map_id": "none", "name": "SFN dimer binds CDK1 and CCNB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10563023", "map_id": "none", "name": "CCNB1:CDK1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10507049", "map_id": "none", "name": "SFN dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10563025", "map_id": "none", "name": "SFN Dimer:CCNB1:CDK1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10563029", "map_id": "none", "name": "SFN dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10507047", "map_id": "none", "name": "Homologues of SFN", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10569796", "map_id": "none", "name": "E2F7 forms homodimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10569792", "map_id": "Q20619", "name": "efl-3", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00009899", "map_id": "WBGene00009899", "name": "efl-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10569794", "map_id": "none", "name": "E2F7 homodimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q20619", "map_id": "Q20619", "name": "efl-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10569802", "map_id": "none", "name": "E2F7 binds E2F8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10569798", "map_id": "Q20619", "name": "efl-3", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10569800", "map_id": "none", "name": "E2F7:E2F8", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10569806", "map_id": "none", "name": "E2F8 forms homodimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10569804", "map_id": "none", "name": "E2F8 homodimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10517733", "map_id": "none", "name": "NPC1L1 inactivation by ezetimibe", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_265479", "map_id": "CHEBI:49040", "name": "EZE", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10517729", "map_id": "none", "name": "Homologues of NPC1L1-1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "P34389", "map_id": "P34389", "name": "ncr-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003562", "map_id": "WBGene00003562", "name": "ncr-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q19127", "map_id": "Q19127", "name": "ncr-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003561", "map_id": "WBGene00003561", "name": "ncr-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10517731", "map_id": "none", "name": "NPC1L1:ezetimibe complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10569030", "map_id": "none", "name": "p-Y705-STAT3 binds p-Y693-STAT4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10568972", "map_id": "none", "name": "Homologues of p-Y693-STAT4", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10531883", "map_id": "none", "name": "Homologues of p-Y705-STAT3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10569014", "map_id": "none", "name": "p-Y705-STAT3:p-Y693-STAT4", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10569018", "map_id": "none", "name": "p-Y705-STAT3:p-Y693-STAT4 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10569016", "map_id": "none", "name": "p-Y705-STAT3:p-Y693-STAT4", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10520825", "map_id": "none", "name": "ADRA1A,B,D bind ADR,NAd", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10519575", "map_id": "G5EBX8", "name": "ser-5", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "WBGene00008890", "map_id": "WBGene00008890", "name": "ser-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_390627", "map_id": "none", "name": "ADR, NAd", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_209794", "map_id": "CHEBI:28918", "name": "ADR", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_209789", "map_id": "CHEBI:18357", "name": "NAd", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10519581", "map_id": "none", "name": "ADRA1A,B,D:ADR,NAd", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "G5EBX8", "map_id": "G5EBX8", "name": "ser-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10520823", "map_id": "none", "name": "\u03b11-agonists:ADRA1A,B,D", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10520821", "map_id": "none", "name": "\u03b11-antagonists:ADRA1A,B,D", "type": "inhibitor", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10520831", "map_id": "none", "name": "ADRA2A,B,C bind ADR,NAd", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10519747", "map_id": "none", "name": "ADRA2A,B,C", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "O02213", "map_id": "O02213", "name": "ser-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004777", "map_id": "WBGene00004777", "name": "ser-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q19084", "map_id": "Q19084", "name": "tyra-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017157", "map_id": "WBGene00017157", "name": "tyra-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10519749", "map_id": "none", "name": "ADRA2A,B,C:ADR,NAd", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10512688", "map_id": "none", "name": "Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10512672", "map_id": "none", "name": "CCNA:p-T160-CDK2:E2F1/E2F3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "A5HWA8", "map_id": "A5HWA8", "name": "phospho-efl-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001162", "map_id": "WBGene00001162", "name": "phospho-efl-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10512685", "map_id": "none", "name": "CCNA:p-T160-CDK2:p-E2F1/p-E2F3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10512674", "map_id": "none", "name": "Association of Cyclin A:phospho-Cdk2(Thr 160) with E2F1/E2F3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10502089", "map_id": "A5HWA8", "name": "efl-2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10502278", "map_id": "none", "name": "CCNA:p-T160-CDK2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10565857", "map_id": "none", "name": "Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10513555", "map_id": "none", "name": "PP2A", "type": "catalyst", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10565838", "map_id": "none", "name": "p-Y307-PP2A", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10565854", "map_id": "none", "name": "Activated SRC,LCK,EGFR,INSR", "type": "catalyst", "sub_type": "", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_1806240", "map_id": "CHEBI:16500", "name": "PI5P", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10537250", "map_id": "none", "name": "PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10537051", "map_id": "O01759", "name": "ppk-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00004087", "map_id": "WBGene00004087", "name": "ppk-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10537082", "map_id": "none", "name": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10537079", "map_id": "none", "name": "PIP4K2 dimers", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10564090", "map_id": "none", "name": "AKT1 dephosphorylation by PP2A-B56-beta,gamma", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10513843", "map_id": "none", "name": "Homologues of p-T308,S473-AKT1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9XTG7", "map_id": "Q9XTG7", "name": "phospho-akt-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000103", "map_id": "WBGene00000103", "name": "phospho-akt-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G4S4W1", "map_id": "G4S4W1", "name": "phospho-p-T308,S473-AKT1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016980", "map_id": "WBGene00016980", "name": "phospho-p-T308,S473-AKT1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q17941", "map_id": "Q17941", "name": "phospho-akt-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000102", "map_id": "WBGene00000102", "name": "phospho-akt-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10520798", "map_id": "none", "name": "Homologues of AKT1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10564085", "map_id": "none", "name": "PP2A-B56-beta,gamma", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "O18178", "map_id": "O18178", "name": "pptr-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012348", "map_id": "WBGene00012348", "name": "pptr-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10543901", "map_id": "none", "name": "PI3K phosphorylates PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10543898", "map_id": "none", "name": "Activator:PI3K", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q94124", "map_id": "Q94124", "name": "rac-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004287", "map_id": "WBGene00004287", "name": "rac-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9BL44", "map_id": "Q9BL44", "name": "RHOH", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022177", "map_id": "WBGene00022177", "name": "RHOH", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A486WY88", "map_id": "A0A486WY88", "name": "cash-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010631", "map_id": "WBGene00010631", "name": "cash-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_1254400", "map_id": "CHEBI:50114", "name": "ESTG", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "A0A1I6CMA1", "map_id": "A0A1I6CMA1", "name": "phospho-Autophosphorylated FLT3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020678", "map_id": "WBGene00020678", "name": "phospho-Autophosphorylated FLT3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EGT9", "map_id": "G5EGT9", "name": "phospho-lin-18", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003007", "map_id": "WBGene00003007", "name": "phospho-lin-18", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9N413", "map_id": "Q9N413", "name": "pvf-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004249", "map_id": "WBGene00004249", "name": "pvf-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10513621", "map_id": "none", "name": "Phosphorylation of phospho- (Ser45, Thr41) beta-catenin at Ser37 by GSK-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10513614", "map_id": "none", "name": "p-T41,S45 CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q21227", "map_id": "Q21227", "name": "apr-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000156", "map_id": "WBGene00000156", "name": "apr-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9U2Q9", "map_id": "Q9U2Q9", "name": "gsk-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001746", "map_id": "WBGene00001746", "name": "gsk-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q09595", "map_id": "Q09595", "name": "GSK3B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010991", "map_id": "WBGene00010991", "name": "GSK3B", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q93372", "map_id": "Q93372", "name": "GSK3B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P42168", "map_id": "P42168", "name": "kin-19", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002202", "map_id": "WBGene00002202", "name": "kin-19", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O62090", "map_id": "O62090", "name": "pry-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004202", "map_id": "WBGene00004202", "name": "pry-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O44326", "map_id": "O44326", "name": "hmp-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10513618", "map_id": "none", "name": "p-S37,T41,S45 CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10513640", "map_id": "none", "name": "Phosphorylation of beta-catenin at Ser45 by CK1 alpha", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10513635", "map_id": "none", "name": "CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10513625", "map_id": "none", "name": "p-S45 CTNNB1:p-Axin:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10513628", "map_id": "none", "name": "Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10513631", "map_id": "none", "name": "Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10513598", "map_id": "none", "name": "p-S33,S37,T41,S45-beta-catenin:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10568784", "map_id": "none", "name": "TLE tetramers bind TCF/LEF at WNT promoters", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10547166", "map_id": "none", "name": "TLE tetramer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "O02482", "map_id": "O02482", "name": "unc-37", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006773", "map_id": "WBGene00006773", "name": "unc-37", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10568780", "map_id": "none", "name": "'canonical' WNT target genes:TCF/LEF", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q10666", "map_id": "Q10666", "name": "pop-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004077", "map_id": "WBGene00004077", "name": "pop-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10568782", "map_id": "none", "name": "'canonical' WNT target gene:TCF/LEF:TLE tetramer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10549443", "map_id": "none", "name": "TLE oligomerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10547150", "map_id": "O02482", "name": "unc-37", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10551337", "map_id": "none", "name": "TCF7L2/TCF7L1 bind CTBP1 to repress WNT target genes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10546301", "map_id": "Q20595", "name": "ctbp-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00006424", "map_id": "WBGene00006424", "name": "ctbp-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10547139", "map_id": "Q10666", "name": "pop-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10551335", "map_id": "none", "name": "TCF7L2/TCF7L1:CTBPs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q20595", "map_id": "Q20595", "name": "ctbp-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10542756", "map_id": "none", "name": "Association of beta-catenin with the RBX1:SCF(beta-TrCP1) ubiquitin ligase complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10516333", "map_id": "none", "name": "BTRC:CUL1:RBX1:SKP1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "G5ECU1", "map_id": "G5ECU1", "name": "skr-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004807", "map_id": "WBGene00004807", "name": "skr-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q17389", "map_id": "Q17389", "name": "cul-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000836", "map_id": "WBGene00000836", "name": "cul-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10513603", "map_id": "none", "name": "p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10542754", "map_id": "none", "name": "RBX1:SKP1:CUL1:beta-TrCP1:phosphorylated beta-catenin complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10513637", "map_id": "none", "name": "Association of beta-catenin with the destruction complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10513587", "map_id": "none", "name": "p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10513633", "map_id": "O44326", "name": "hmp-2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10550824", "map_id": "none", "name": "AXIN is phosphorylated in the destruction complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10515030", "map_id": "none", "name": "AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10513608", "map_id": "none", "name": "Phosphorylation of APC component of the destruction complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10513610", "map_id": "none", "name": "Dissociation of beta-catenin from Axin and association of beta catenin with phospho-(20 aa) APC in the detruction complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10542762", "map_id": "none", "name": "Degradation of ubiquitinated beta catenin by the proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10542758", "map_id": "none", "name": "ubiquitinated phospho-beta-catenin:RBX1:SCF(beta-TrCP1) complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10542760", "map_id": "none", "name": "p-AXIN:CK1alpha:GSK3B:phospho-APC (20 aa repeat region):PP2A:AMER1 complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10542764", "map_id": "none", "name": "Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10569984", "map_id": "none", "name": "PGM2L1:Mg2+ phosphorylates G6P to G1,6BP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29800", "map_id": "CHEBI:57604", "name": "1,3BPG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_8955759", "map_id": "CHEBI:18148", "name": "G1,6BP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_29728", "map_id": "CHEBI:58272", "name": "3PG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10502853", "map_id": "none", "name": "PGM2L1:Mg2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "O45934", "map_id": "O45934", "name": "PGM2L1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012803", "map_id": "WBGene00012803", "name": "PGM2L1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10504330", "map_id": "none", "name": "D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_30533", "map_id": "CHEBI:28602", "name": "D-Fructose 2,6-bisphosphate", "type": "catalyst", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10504327", "map_id": "none", "name": "PFKFB dimers", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q21122", "map_id": "Q21122", "name": "pfkb-1.2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019295", "map_id": "WBGene00019295", "name": "pfkb-1.2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9N590", "map_id": "Q9N590", "name": "pfkb-1.1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022456", "map_id": "WBGene00022456", "name": "pfkb-1.1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10502842", "map_id": "none", "name": "Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10502839", "map_id": "none", "name": "phosphoPFKFB1 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10504194", "map_id": "none", "name": "2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_30485", "map_id": "CHEBI:58289", "name": "2PG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_29492", "map_id": "CHEBI:58702", "name": "PEP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10503109", "map_id": "none", "name": "enolase dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q27527", "map_id": "Q27527", "name": "enol-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011884", "map_id": "WBGene00011884", "name": "enol-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10557538", "map_id": "none", "name": "ADPGK:Mg2+ phosphorylates Glc to G6P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_70113", "map_id": "CHEBI:17925", "name": "Glc", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10557535", "map_id": "none", "name": "ADPGK:Mg2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q86S40", "map_id": "Q86S40", "name": "ADPGK", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016810", "map_id": "WBGene00016810", "name": "ADPGK", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10504004", "map_id": "none", "name": "D-fructose 1,6-bisphosphate <=> dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_30014", "map_id": "CHEBI:32966", "name": "F1,6PP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_29578", "map_id": "CHEBI:59776", "name": "GA3P", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_75970", "map_id": "CHEBI:57642", "name": "DHAP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10503999", "map_id": "none", "name": "aldolase tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P54216", "map_id": "P54216", "name": "aldo-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011474", "map_id": "WBGene00011474", "name": "aldo-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P46563", "map_id": "P46563", "name": "aldo-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017166", "map_id": "WBGene00017166", "name": "aldo-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10503048", "map_id": "none", "name": "D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10503045", "map_id": "none", "name": "PFK tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9TZL8", "map_id": "Q9TZL8", "name": "pfk-1.1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022199", "map_id": "WBGene00022199", "name": "pfk-1.1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q27483", "map_id": "Q27483", "name": "pfk-1.2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008230", "map_id": "WBGene00008230", "name": "pfk-1.2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10511375", "map_id": "none", "name": "glucokinase [nucleoplasm] => glucokinase [cytosol]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13231", "compartment_display": "nuclear envelope" }, { "id": "species_10511373", "map_id": "none", "name": "Homologues of GCK", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q19440", "map_id": "Q19440", "name": "hxk-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008780", "map_id": "WBGene00008780", "name": "hxk-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9N4A5", "map_id": "Q9N4A5", "name": "hxk-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022306", "map_id": "WBGene00022306", "name": "hxk-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XU15", "map_id": "Q9XU15", "name": "hxk-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010416", "map_id": "WBGene00010416", "name": "hxk-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10502937", "map_id": "none", "name": "Homologues of GCK", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10502958", "map_id": "none", "name": "HK1,2,3,GCK phosphorylate Glc to form G6P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10502955", "map_id": "none", "name": "glucokinase and hexokinases", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10504334", "map_id": "none", "name": "1,3-bisphospho-D-glycerate + ADP <=> 3-phospho-D-glycerate + ATP", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10503093", "map_id": "none", "name": "PGK complexes", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P91427", "map_id": "P91427", "name": "pgk-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020185", "map_id": "WBGene00020185", "name": "pgk-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10502997", "map_id": "none", "name": "D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10502994", "map_id": "none", "name": "GAPDH tetramers", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P04970", "map_id": "P04970", "name": "gpd-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001683", "map_id": "WBGene00001683", "name": "gpd-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P17329", "map_id": "P17329", "name": "gpd-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001684", "map_id": "WBGene00001684", "name": "gpd-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P17330", "map_id": "P17330", "name": "gpd-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001685", "map_id": "WBGene00001685", "name": "gpd-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P17331", "map_id": "P17331", "name": "gpd-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001686", "map_id": "WBGene00001686", "name": "gpd-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10562107", "map_id": "none", "name": "GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_449701", "map_id": "CHEBI:15873", "name": "GlcN6P", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10562104", "map_id": "none", "name": "GNPDA1,2 hexamers", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9XVJ2", "map_id": "Q9XVJ2", "name": "GNPDA2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011399", "map_id": "WBGene00011399", "name": "GNPDA2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10504221", "map_id": "none", "name": "phosphoenolpyruvate + ADP => pyruvate + ATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29398", "map_id": "CHEBI:15361", "name": "PYR", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10504218", "map_id": "none", "name": "pyruvate kinase tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_74126", "map_id": "CHEBI:29103", "name": "K+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "B7WNA0", "map_id": "B7WNA0", "name": "pyk-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009126", "map_id": "WBGene00009126", "name": "pyk-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q23539", "map_id": "Q23539", "name": "pyk-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00014001", "map_id": "WBGene00014001", "name": "pyk-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10503007", "map_id": "none", "name": "dihydroxyacetone phosphate <=> D-glyceraldehyde 3-phosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10503004", "map_id": "none", "name": "TPI1 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q10657", "map_id": "Q10657", "name": "tpi-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006601", "map_id": "WBGene00006601", "name": "tpi-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10529025", "map_id": "none", "name": "PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_916850", "map_id": "CHEBI:59888", "name": "GABA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_113594", "map_id": "CHEBI:16810", "name": "2OG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_880046", "map_id": "CHEBI:57706", "name": "SUCCSA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10529022", "map_id": "none", "name": "PXLP-K357-ABAT dimer:2Fe-2S", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "CHEBI:33739", "map_id": "CHEBI:33739", "name": "CHEBI:33739", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q21217", "map_id": "Q21217", "name": "gta-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001794", "map_id": "WBGene00001794", "name": "gta-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10528302", "map_id": "none", "name": "ALDH5A1 dehydrogenates SUCCSA to SUCCA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_113526", "map_id": "CHEBI:57540", "name": "NAD+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_29362", "map_id": "CHEBI:57945", "name": "NADH", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_113536", "map_id": "CHEBI:30031", "name": "SUCCA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10528299", "map_id": "none", "name": "ALDH5A1 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "O02266", "map_id": "O02266", "name": "alh-7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000113", "map_id": "WBGene00000113", "name": "alh-7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10550736", "map_id": "none", "name": "WDR5 binds Me2sR3-replicative histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10550011", "map_id": "Q17963", "name": "wdr-5.1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00006474", "map_id": "WBGene00006474", "name": "wdr-5.1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10550698", "map_id": "none", "name": "Me2sR3-histone H3", "type": "inhibitor", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10550734", "map_id": "none", "name": "WDR5:Me2sR3-histone H3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q17963", "map_id": "Q17963", "name": "wdr-5.1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10550706", "map_id": "none", "name": "PRMT5:WDR77, PRMT7 methylate arginine-3 of histone H3 (H3R2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_77087", "map_id": "CHEBI:15414", "name": "AdoMet", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10546551", "map_id": "none", "name": "Histone H3", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_77502", "map_id": "CHEBI:16680", "name": "AdoHcy", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10550703", "map_id": "Q9XW42", "name": "prmt-7", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00012298", "map_id": "WBGene00012298", "name": "prmt-7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10554499", "map_id": "none", "name": "PRMT1,PRMT6 methylate methyl-lysine-4 of histone H4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10550424", "map_id": "P62784", "name": "his-56", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00001875", "map_id": "WBGene00001875", "name": "his-56", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10554497", "map_id": "P62784", "name": "his-56", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10546564", "map_id": "Q9U2X0", "name": "prmt-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00013766", "map_id": "WBGene00013766", "name": "prmt-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10550740", "map_id": "none", "name": "RBBP7 binds histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10517096", "map_id": "none", "name": "Homologues of RBBP7", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "P90916", "map_id": "P90916", "name": "lin-53", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003036", "map_id": "WBGene00003036", "name": "lin-53", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P90917", "map_id": "P90917", "name": "rba-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004312", "map_id": "WBGene00004312", "name": "rba-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10550738", "map_id": "none", "name": "RBBP7:Replicative histone H3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10550506", "map_id": "none", "name": "PRMT1 methylates arginine-12 of histone H2A (H2AR11)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10550491", "map_id": "none", "name": "MeR12-histone H2A, Histone H2A", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10550504", "map_id": "none", "name": "Me2aR12-histone H2A, MeR12-histone H2A", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10550427", "map_id": "none", "name": "PRMT1,PRMT6 methylate arginine-4 of histone H4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10506929", "map_id": "P62784", "name": "his-56", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10554048", "map_id": "none", "name": "MECOM (KMT8E), PRDM16 (KMT8F) methylate lysine-10 of replicative histone H3 (H3K9)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10554034", "map_id": "none", "name": "Histone H3", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10554038", "map_id": "none", "name": "MeK10-histone H3", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10554043", "map_id": "Q22024", "name": "egl-43", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00001207", "map_id": "WBGene00001207", "name": "egl-43", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10554160", "map_id": "none", "name": "WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C), ASH1L methylate methyl-lysine-37 of histone H3 (H3K36)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10549582", "map_id": "none", "name": "MeK37-histone H3", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10554153", "map_id": "none", "name": "Me2K37-histone H3", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10549759", "map_id": "none", "name": "Homologues of SMYD2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q23084", "map_id": "Q23084", "name": "set-30", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022499", "map_id": "WBGene00022499", "name": "set-30", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8I4F7", "map_id": "Q8I4F7", "name": "set-18", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00044070", "map_id": "WBGene00044070", "name": "set-18", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XV44", "map_id": "Q9XV44", "name": "set-10", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009370", "map_id": "WBGene00009370", "name": "set-10", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q09415", "map_id": "Q09415", "name": "set-14", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011068", "map_id": "WBGene00011068", "name": "set-14", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10549762", "map_id": "none", "name": "WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C) methylate lysine-37 of histone H3 (H3K36)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10554178", "map_id": "none", "name": "DOT1L (KMT4) methylates methyl-lysine-80 of histone H3 (H3K79)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10554165", "map_id": "none", "name": "MeK80-histone H3", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10554170", "map_id": "none", "name": "Me2K80-histone H3", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10554175", "map_id": "Q6AW06", "name": "dot-1.1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00021474", "map_id": "WBGene00021474", "name": "dot-1.1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10550023", "map_id": "none", "name": "SETD3, SETD7 (KMT7), WHSC1L1 (KMT3F), Core MLL complex methylate lysine-5 of histone H3 (H3K4)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10546549", "map_id": "none", "name": "MeK5-histone H3", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10550020", "map_id": "none", "name": "SETD3, SETD7, WHSC1L1, Core MLL complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9BL48", "map_id": "Q9BL48", "name": "set-27", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022173", "map_id": "WBGene00022173", "name": "set-27", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q10661", "map_id": "Q10661", "name": "dpy-30", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001088", "map_id": "WBGene00001088", "name": "dpy-30", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EFZ3", "map_id": "G5EFZ3", "name": "ash-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012458", "map_id": "WBGene00012458", "name": "ash-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q09309", "map_id": "Q09309", "name": "rbbp-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017683", "map_id": "WBGene00017683", "name": "rbbp-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q18221", "map_id": "Q18221", "name": "set-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004782", "map_id": "WBGene00004782", "name": "set-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EGI1", "map_id": "G5EGI1", "name": "set-16", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011729", "map_id": "WBGene00011729", "name": "set-16", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10552342", "map_id": "none", "name": "SETD8 (KMT5A) methylates lysine-21 of histone H4 (H4K20)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10543366", "map_id": "P62784", "name": "his-56", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10543801", "map_id": "Q22795", "name": "set-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00004781", "map_id": "WBGene00004781", "name": "set-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10554185", "map_id": "none", "name": "DOT1L (KMT4) methylates dimethyl-lysine-80 of histone H3 (H3K79)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10554183", "map_id": "none", "name": "Me3K80-histone H3", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10550985", "map_id": "none", "name": "Core MLL complex, SMYD3, PRDM9 methylate dimethyl-lysine-5 of histone H3 (H3K4)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10549629", "map_id": "none", "name": "Me2K5-histone H3", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10550978", "map_id": "none", "name": "Me3K5-histone H3", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10550982", "map_id": "none", "name": "Core MLL complex, SMYD3, PRDM9", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10550471", "map_id": "none", "name": "Me2aR3-histone H3, MeR3-histone H3", "type": "inhibitor", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10549737", "map_id": "none", "name": "SUV39H1 (KMT1A), SUV39H2 (KTM1B), SETDB1 (KMT1E), SETDB2 (KMT1F) methylate dimethyl-lysine-10 of histone H3 (H3K9)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10549601", "map_id": "none", "name": "Me2K10-histone H3", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10549722", "map_id": "none", "name": "Me3K10-histone H3", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10549734", "map_id": "none", "name": "SUV39H1, SUV39H2, SETDB1, SETDB2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "P34544", "map_id": "P34544", "name": "met-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019883", "map_id": "WBGene00019883", "name": "met-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10554187", "map_id": "none", "name": "DOT1L (KMT4) methylates lysine-80 of histone H3 (H3K79)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10554110", "map_id": "none", "name": "WHSC1L1 (KMT3F), Core MLL complex, SMYD3 (KMT3E) methylate methyl-lysine-5 of histone H3 (H3K4)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10554107", "map_id": "none", "name": "WHSC1L1, Core MLL complex, SMYD3, SETD3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10549670", "map_id": "none", "name": "KDM6A, KDM6B, KDM7A demethylate Me2K28-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_113671", "map_id": "CHEBI:16810", "name": "2OG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_113685", "map_id": "CHEBI:15379", "name": "O2", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10549648", "map_id": "none", "name": "Me2K28-histone H3", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_29478", "map_id": "CHEBI:16842", "name": "CH2O", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10549653", "map_id": "none", "name": "MeK28-histone H3", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_159942", "map_id": "CHEBI:16526", "name": "CO2", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_159939", "map_id": "CHEBI:30031", "name": "SUCCA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10549667", "map_id": "none", "name": "KDM6A,KDM6B,KDM6C,KDM7A", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q19760", "map_id": "Q19760", "name": "jmjd-3.2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009089", "map_id": "WBGene00009089", "name": "jmjd-3.2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q95QK3", "map_id": "Q95QK3", "name": "jmjd-3.1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017571", "map_id": "WBGene00017571", "name": "jmjd-3.1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q20367", "map_id": "Q20367", "name": "jmjd-1.1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00005013", "map_id": "WBGene00005013", "name": "jmjd-1.1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9GYI0", "map_id": "Q9GYI0", "name": "jmjd-1.2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017920", "map_id": "WBGene00017920", "name": "jmjd-1.2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10554473", "map_id": "none", "name": "KDM2A, KDM2B, KDM4A demethylate Me2K37-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10549596", "map_id": "none", "name": "KDM2A, KDM2B, KDM4A", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q95Q98", "map_id": "Q95Q98", "name": "jhdm-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020821", "map_id": "WBGene00020821", "name": "jhdm-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9U297", "map_id": "Q9U297", "name": "jmjd-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012982", "map_id": "WBGene00012982", "name": "jmjd-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10549608", "map_id": "none", "name": "KDM4A, KDM4B, KDM4C, KDM4D demethylate Me2K10-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10549603", "map_id": "none", "name": "MeK10-histone H3", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10549594", "map_id": "Q9U297", "name": "jmjd-2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10554475", "map_id": "none", "name": "KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate Me2K10-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10549616", "map_id": "none", "name": "KDM3A,KDM3B,KDM7A,PHF2:ARID5B,PHF8", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10549643", "map_id": "none", "name": "KDM5A-D demethylate Me2K5-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10549634", "map_id": "Q23541", "name": "rbr-2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00004319", "map_id": "WBGene00004319", "name": "rbr-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10554477", "map_id": "none", "name": "KDM5A-D demethylate Me3K5-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10549619", "map_id": "none", "name": "KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate MeK10-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10554484", "map_id": "none", "name": "KDM4A, KDM4B, KDM4C, KDM4D, MINA demethylate Me3K10-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10554486", "map_id": "none", "name": "KDM6A, KDM6B, KDM7A demethylate Me3K28-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10554189", "map_id": "none", "name": "Me3K28-histone H3", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10552345", "map_id": "none", "name": "PHF8 demethylates MeK21-histone H4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10543372", "map_id": "Q9GYI0", "name": "jmjd-1.2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10554488", "map_id": "none", "name": "JMJD6 demethylates Me2R3-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10550469", "map_id": "none", "name": "Me2aR3-histone H3", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10546774", "map_id": "none", "name": "MeR3-histone H3", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10549624", "map_id": "Q9GYI4", "name": "psr-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00004205", "map_id": "WBGene00004205", "name": "psr-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10554490", "map_id": "none", "name": "KDM1A, KDM1B demethylate Me2K5-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10546556", "map_id": "Q21988", "name": "amx-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00000137", "map_id": "WBGene00000137", "name": "amx-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10549627", "map_id": "none", "name": "JMJD6 demethylates MeR3-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10554492", "map_id": "none", "name": "JMJD6 demethylates MeR4-HIST1H4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10546559", "map_id": "none", "name": "KDM1A, KDM1B demethylate MeK5-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10549599", "map_id": "none", "name": "KDM2A, KDM2B, KDM4A demethylate MeK37-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10554494", "map_id": "none", "name": "JMJD6 demethylates Me2sR4-HIST1H4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10550476", "map_id": "P62784", "name": "his-56", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10547753", "map_id": "none", "name": "Type B histone acetlytransferase complex acetylates histone H4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_113560", "map_id": "CHEBI:15351", "name": "Ac-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_2485002", "map_id": "CHEBI:15346", "name": "CoA-SH", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10547743", "map_id": "P62784", "name": "his-56", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10547750", "map_id": "none", "name": "HAT1:RBBP7", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q21484", "map_id": "Q21484", "name": "hat-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00044069", "map_id": "WBGene00044069", "name": "hat-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10547932", "map_id": "none", "name": "EP300 acetylates histone H2A, H2B, H3, H4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10547761", "map_id": "none", "name": "Histone H2A, H2B, H3, H4", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10547929", "map_id": "none", "name": "AcK-histone H2A, H2B, H3, H4", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10532228", "map_id": "P34545", "name": "cbp-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00000366", "map_id": "WBGene00000366", "name": "cbp-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10547276", "map_id": "none", "name": "ATF2 acetylates histone H2B, H4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10547238", "map_id": "none", "name": "Histone H2B, H4", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "P62784", "map_id": "P62784", "name": "his-56", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q27484", "map_id": "Q27484", "name": "his-41", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001915", "map_id": "WBGene00001915", "name": "his-41", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q27876", "map_id": "Q27876", "name": "his-58", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001922", "map_id": "WBGene00001922", "name": "his-58", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q27894", "map_id": "Q27894", "name": "his-54", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001878", "map_id": "WBGene00001878", "name": "his-54", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P04255", "map_id": "P04255", "name": "his-34", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001885", "map_id": "WBGene00001885", "name": "his-34", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10547273", "map_id": "none", "name": "AcK-replicative histone H2B, H4", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10548040", "map_id": "none", "name": "HDAC1:2-containing complex deacetylate histones", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10547965", "map_id": "none", "name": "Acetylated core histone octamer", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10547971", "map_id": "none", "name": "Core histone octamer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_5566518", "map_id": "CHEBI:30089", "name": "acetate", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10548037", "map_id": "none", "name": "HDAC1:2-containing complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "G5ECR1", "map_id": "G5ECR1", "name": "mbd-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00023409", "map_id": "WBGene00023409", "name": "mbd-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O61907", "map_id": "O61907", "name": "lin-40", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003025", "map_id": "WBGene00003025", "name": "lin-40", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5ECH0", "map_id": "G5ECH0", "name": "hda-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001836", "map_id": "WBGene00001836", "name": "hda-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q09440", "map_id": "Q09440", "name": "hda-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001835", "map_id": "WBGene00001835", "name": "hda-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9NF71", "map_id": "Q9NF71", "name": "RCOR1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013632", "map_id": "WBGene00013632", "name": "RCOR1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O18691", "map_id": "O18691", "name": "RCOR1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q18919", "map_id": "Q18919", "name": "spr-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00005006", "map_id": "WBGene00005006", "name": "spr-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q95Y41", "map_id": "Q95Y41", "name": "rcor-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022278", "map_id": "WBGene00022278", "name": "rcor-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A5JYT9", "map_id": "A5JYT9", "name": "row-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009508", "map_id": "WBGene00009508", "name": "row-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q11107", "map_id": "Q11107", "name": "lin-13", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003002", "map_id": "WBGene00003002", "name": "lin-13", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10548187", "map_id": "none", "name": "HDAC10 deacetylates histone", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10548184", "map_id": "Q9U266", "name": "hda-10", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00001838", "map_id": "WBGene00001838", "name": "hda-10", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10520785", "map_id": "none", "name": "propionyl-CoA + carnitine => propionylcarnitine + CoASH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_192314", "map_id": "CHEBI:15539", "name": "propionyl CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_390294", "map_id": "CHEBI:17126", "name": "CAR", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_193514", "map_id": "CHEBI:15346", "name": "CoA-SH", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_390274", "map_id": "CHEBI:28867", "name": "Propionylcarnitine", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_10520782", "map_id": "Q17499", "name": "CRAT", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "WBGene00007175", "map_id": "WBGene00007175", "name": "CRAT", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10520754", "map_id": "none", "name": "trans-2,3-dehydropristanoyl-CoA + H2O => 3-hydroxypristanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_141343", "map_id": "CHEBI:15377", "name": "H2O", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_389894", "map_id": "CHEBI:63803", "name": "trans-2,3-dehydropristanoyl-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_389982", "map_id": "CHEBI:63914", "name": "3-hydroxypristanoyl-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_10513270", "map_id": "none", "name": "HSD17B4 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "true" }, { "id": "Q19058", "map_id": "Q19058", "name": "maoc-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017123", "map_id": "WBGene00017123", "name": "maoc-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10520739", "map_id": "none", "name": "ACOX2:FAD, ACOXL:FAD oxidise (2S)-pristanoyl-CoA to trans-2,3-dehydropristanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_113535", "map_id": "CHEBI:15379", "name": "O2", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_389893", "map_id": "CHEBI:64039", "name": "(2S) Pristanoyl-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_113575", "map_id": "CHEBI:16240", "name": "H2O2", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_10513307", "map_id": "none", "name": "ACOX2:FAD", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "true" }, { "id": "P34355", "map_id": "P34355", "name": "acox-1.5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008167", "map_id": "WBGene00008167", "name": "acox-1.5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O62138", "map_id": "O62138", "name": "acox-1.3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008566", "map_id": "WBGene00008566", "name": "acox-1.3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q93839", "map_id": "Q93839", "name": "acox-1.6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010336", "map_id": "WBGene00010336", "name": "acox-1.6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O62139", "map_id": "O62139", "name": "acox-1.4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008567", "map_id": "WBGene00008567", "name": "acox-1.4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O62140", "map_id": "O62140", "name": "acox-1.1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008564", "map_id": "WBGene00008564", "name": "acox-1.1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O62137", "map_id": "O62137", "name": "acox-1.2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008565", "map_id": "WBGene00008565", "name": "acox-1.2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10520787", "map_id": "none", "name": "acetyl-CoA + carnitine => acetylcarnitine + CoASH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_353123", "map_id": "CHEBI:15351", "name": "Ac-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_390287", "map_id": "CHEBI:15960", "name": "ACAR", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "reaction_10520756", "map_id": "none", "name": "3-hydroxypristanoyl-CoA + NAD+ => 3-ketoxypristanoyl-CoA + NADH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_192307", "map_id": "CHEBI:57540", "name": "NAD+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_193465", "map_id": "CHEBI:15378", "name": "H+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_389996", "map_id": "CHEBI:15371", "name": "3-ketopristanoyl-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_192305", "map_id": "CHEBI:57945", "name": "NADH", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "reaction_10520790", "map_id": "none", "name": "acetyl-CoA + H2O => acetate + CoASH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_390305", "map_id": "CHEBI:15366", "name": "CH3COO-", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_10513389", "map_id": "Q9BIA9", "name": "ACOT8", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "WBGene00015887", "map_id": "WBGene00015887", "name": "ACOT8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10520777", "map_id": "none", "name": "4,8-dimethylnonanoyl-CoA + carnitine => 4,8-dimethylnonanoylcarnitine + CoASH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_390271", "map_id": "CHEBI:63856", "name": "4,8-dimethylnonanoyl-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_390290", "map_id": "CHEBI:63874", "name": "4,8-dimethylnonanoylcarnitine", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_10520774", "map_id": "A0A486WVT5", "name": "CROT", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "WBGene00011850", "map_id": "WBGene00011850", "name": "CROT", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10520749", "map_id": "none", "name": "(2S)-pristanoyl-CoA + O2 => trans-2,3-dehydropristanoyl-CoA + H2O2 (ACOX3)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_10520746", "map_id": "none", "name": "ACOX3:FAD", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "true" }, { "id": "Q20992", "map_id": "Q20992", "name": "acox-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019060", "map_id": "WBGene00019060", "name": "acox-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10520751", "map_id": "none", "name": "Isomerization of (2R)-pristanoyl-CoA to (2S)-pristanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_389569", "map_id": "CHEBI:51341", "name": "(2R) Pristanoyl-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_10513241", "map_id": "Q18122", "name": "AMACR", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "WBGene00016034", "map_id": "WBGene00016034", "name": "AMACR", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10513025", "map_id": "none", "name": "HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_191293", "map_id": "CHEBI:15345", "name": "ACA-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_191374", "map_id": "CHEBI:15467", "name": "bHMG-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10513022", "map_id": "P54871", "name": "hmgs-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00017769", "map_id": "WBGene00017769", "name": "hmgs-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10513507", "map_id": "none", "name": "4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_194735", "map_id": "CHEBI:63842", "name": "4C4MZYMOL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_194667", "map_id": "CHEBI:50593", "name": "dh4MZYMOL", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10513504", "map_id": "Q9XWF0", "name": "hsd-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "WBGene00012394", "map_id": "WBGene00012394", "name": "hsd-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10513509", "map_id": "none", "name": "4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_194657", "map_id": "CHEBI:63844", "name": "4CZYMOL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_194661", "map_id": "CHEBI:52386", "name": "ZYMONE", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "reaction_10513665", "map_id": "none", "name": "Cholesta-5,7,24-trien-3beta-ol is reduced to desmosterol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_195655", "map_id": "CHEBI:27910", "name": "7dhDESOL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_196420", "map_id": "CHEBI:17737", "name": "DESMOL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10513662", "map_id": "G5ED82", "name": "dhcr-7", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "WBGene00007126", "map_id": "WBGene00007126", "name": "dhcr-7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10513673", "map_id": "none", "name": "Reduction of desmosterol to cholesterol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_193384", "map_id": "CHEBI:16113", "name": "CHOL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10513670", "map_id": "O17397", "name": "DHCR24", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "WBGene00018718", "map_id": "WBGene00018718", "name": "DHCR24", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10513065", "map_id": "none", "name": "MVD decarboxylates MVA5PP to IPPP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_191403", "map_id": "CHEBI:15899", "name": "MVA5PP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_191362", "map_id": "CHEBI:16584", "name": "IPPP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10513062", "map_id": "none", "name": "MVD dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9U294", "map_id": "Q9U294", "name": "MVD", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012984", "map_id": "WBGene00012984", "name": "MVD", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10513035", "map_id": "none", "name": "HMGCR dimer reduces bHMG-CoA to MVA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_191424", "map_id": "CHEBI:17710", "name": "MVA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10513032", "map_id": "none", "name": "HMGCR dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q19207", "map_id": "Q19207", "name": "hmgr-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017268", "map_id": "WBGene00017268", "name": "hmgr-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10563129", "map_id": "none", "name": "DHCR7 reduces 7-dehydroCHOL to CHOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_6807057", "map_id": "CHEBI:17759", "name": "7-dehydroCHOL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "reaction_10563131", "map_id": "none", "name": "DHCR24 reduces ZYMOL to ZYMSTNL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_194691", "map_id": "CHEBI:18252", "name": "ZYMOL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_6807048", "map_id": "CHEBI:16608", "name": "ZYMSTNL", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "reaction_10513073", "map_id": "none", "name": "Mevalonate-5-phosphate is further phosphorylated.", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_191296", "map_id": "CHEBI:17436", "name": "MVA5P", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10513070", "map_id": "I2HAD9", "name": "PMVK", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00009335", "map_id": "WBGene00009335", "name": "PMVK", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10513045", "map_id": "none", "name": "Mevalonate is phosphorylated to mevalonate-5-phosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10513042", "map_id": "none", "name": "MVK dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q65XX9", "map_id": "Q65XX9", "name": "mvk-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021534", "map_id": "WBGene00021534", "name": "mvk-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10569175", "map_id": "none", "name": "Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_191265", "map_id": "CHEBI:15442", "name": "PSQPP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_8952135", "map_id": "CHEBI:134117", "name": "presqualene monophosphate", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10569172", "map_id": "Q22461", "name": "PLPP6", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "WBGene00020486", "map_id": "WBGene00020486", "name": "PLPP6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10513017", "map_id": "none", "name": "Another isopentenyl pyrophosphate is added to geranyl pyrophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_191409", "map_id": "CHEBI:17211", "name": "GPP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_191385", "map_id": "CHEBI:17407", "name": "FAPP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10513014", "map_id": "none", "name": "2(FDPS:3Mg2+)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "O62336", "map_id": "O62336", "name": "fdps-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011058", "map_id": "WBGene00011058", "name": "fdps-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10551001", "map_id": "none", "name": "ARV1 transports CHOL from ER membrane to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_171095", "map_id": "CHEBI:16113", "name": "CHOL", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10550998", "map_id": "Q21765", "name": "arv-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "WBGene00011040", "map_id": "WBGene00011040", "name": "arv-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10513020", "map_id": "none", "name": "Addition of isopentenyl pyrophosphate to DMAPP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_191324", "map_id": "CHEBI:16057", "name": "DMAPP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10513055", "map_id": "none", "name": "Isopentenyl pyrophosphate rearranges to dimethylallyl pyrophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10513052", "map_id": "none", "name": "IDI1 or 2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "G5EFQ1", "map_id": "G5EFQ1", "name": "idi-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019460", "map_id": "WBGene00019460", "name": "idi-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10546084", "map_id": "none", "name": "Transfer of SUMO1 from E1 to UBE2I (UBC9)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10546073", "map_id": "Q95017", "name": "ubc-9", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00006706", "map_id": "WBGene00006706", "name": "ubc-9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10546009", "map_id": "none", "name": "SUMO1:UBA2:SAE1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9NAN1", "map_id": "Q9NAN1", "name": "uba-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006700", "map_id": "WBGene00006700", "name": "uba-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q17820", "map_id": "Q17820", "name": "aos-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000142", "map_id": "WBGene00000142", "name": "aos-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10546081", "map_id": "none", "name": "SUMO1:C93-UBE2I", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q95017", "map_id": "Q95017", "name": "ubc-9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10545999", "map_id": "none", "name": "UBA2:SAE1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10563041", "map_id": "none", "name": "HMGB1 binds LTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10563037", "map_id": "none", "name": "Homologues of HC23,45-HMGB1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "G5EFV4", "map_id": "G5EFV4", "name": "hmg-1.1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001971", "map_id": "WBGene00001971", "name": "hmg-1.1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q09390", "map_id": "Q09390", "name": "hmg-1.2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001972", "map_id": "WBGene00001972", "name": "hmg-1.2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_181015", "map_id": "CHEBI:28640", "name": "Lipoteichoic acid", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10563039", "map_id": "none", "name": "HC23,45-HMGB1:LTA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10563090", "map_id": "none", "name": "HMGB1 release from cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10517878", "map_id": "none", "name": "Homologues of HMGB1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10563045", "map_id": "none", "name": "HMGB1 binds LPS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_166005", "map_id": "CHEBI:16412", "name": "LPS", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10563043", "map_id": "none", "name": "HC23,45-HMGB1:LPS", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10566733", "map_id": "none", "name": "oxPL binds LBP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10510717", "map_id": "none", "name": "Homologues of LBP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "Q20380", "map_id": "Q20380", "name": "LBP", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022627", "map_id": "WBGene00022627", "name": "LBP", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q17654", "map_id": "Q17654", "name": "LBP", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "H9G2Z8", "map_id": "H9G2Z8", "name": "LBP", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q23365", "map_id": "Q23365", "name": "LBP", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q17738", "map_id": "Q17738", "name": "LBP", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O17768", "map_id": "O17768", "name": "LBP", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q93796", "map_id": "Q93796", "name": "nrf-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003812", "map_id": "WBGene00003812", "name": "nrf-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q18869", "map_id": "Q18869", "name": "LBP", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q10011", "map_id": "Q10011", "name": "BPI", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020563", "map_id": "WBGene00020563", "name": "BPI", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A8WFJ7", "map_id": "A8WFJ7", "name": "LBP", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_2186967", "map_id": "CHEBI:60156", "name": "oxidized phospholipids", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10566731", "map_id": "none", "name": "LBP:oxPL", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10510723", "map_id": "none", "name": "Association of LBP with LPS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10510719", "map_id": "none", "name": "LBP:bacterial LPS", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10510721", "map_id": "Q10011", "name": "BPI", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10569028", "map_id": "none", "name": "p-Y693-STAT4 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10568974", "map_id": "none", "name": "p-Y693-STAT4 dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10568984", "map_id": "none", "name": "Y693-STAT4 dimer translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10568982", "map_id": "none", "name": "Y963-STAT4 dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10569026", "map_id": "none", "name": "IL27RA dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10569022", "map_id": "Q9UB28", "name": "let-805", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "WBGene00002915", "map_id": "WBGene00002915", "name": "let-805", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10569024", "map_id": "none", "name": "2xIL27RA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9UB28", "map_id": "Q9UB28", "name": "let-805", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10569032", "map_id": "none", "name": "p-STAT1 binds p-STAT3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10528453", "map_id": "none", "name": "Homologues of p-Y701-STAT1-1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10531889", "map_id": "none", "name": "p-Y701-STAT1: p-Y-705-STAT3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10569020", "map_id": "none", "name": "p-Y701-STAT1:p-Y705-STAT3 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10531901", "map_id": "none", "name": "p-Y701-STAT1:p-Y705-STAT3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10568990", "map_id": "none", "name": "CANX binds EBI3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_10568986", "map_id": "Q9UB28", "name": "let-805", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10527249", "map_id": "P34652", "name": "cnx-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "WBGene00000567", "map_id": "WBGene00000567", "name": "cnx-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10568988", "map_id": "none", "name": "CANX:EBI3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "P34652", "map_id": "P34652", "name": "cnx-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10569012", "map_id": "none", "name": "p-STAT1:p-STAT4 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10569008", "map_id": "none", "name": "p-STAT1:p-STAT4", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10569010", "map_id": "none", "name": "p-Y693-STAT4:p-Y701-STAT1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10521955", "map_id": "none", "name": "ROCK activation by RHO", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10521949", "map_id": "none", "name": "ROCK1,ROCK2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P92199", "map_id": "P92199", "name": "let-502", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002694", "map_id": "WBGene00002694", "name": "let-502", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q21025", "map_id": "Q21025", "name": "ROCK2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019087", "map_id": "WBGene00019087", "name": "ROCK2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XVH4", "map_id": "Q9XVH4", "name": "ROCK2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10509488", "map_id": "none", "name": "RHOA:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10521951", "map_id": "none", "name": "Activated ROCK:RhoA/B/C:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10521953", "map_id": "none", "name": "ROCK1,ROCK2:ROCKi", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10573094", "map_id": "none", "name": "ROCK1,2 bind ROCKi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9686558", "map_id": "none", "name": "ROCKi", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10514868", "map_id": "none", "name": "Caspase-mediated cleavage of alpha adducin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10514862", "map_id": "Q20952", "name": "add-2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00000073", "map_id": "WBGene00000073", "name": "add-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10514866", "map_id": "Q20952", "name": "add-2", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10514864", "map_id": "Q20952", "name": "add-2", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10509422", "map_id": "none", "name": "Caspase-3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P42573", "map_id": "P42573", "name": "phospho-ced-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000417", "map_id": "WBGene00000417", "name": "phospho-ced-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10515348", "map_id": "none", "name": "Caspase mediated cleavage of HIP-55", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10515346", "map_id": "Q9XUT0", "name": "dbn-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10515344", "map_id": "Q9XUT0", "name": "dbn-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10515359", "map_id": "none", "name": "Caspase mediated cleavage of alpha-II-Fodrin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10515353", "map_id": "Q21408", "name": "spc-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00004951", "map_id": "WBGene00004951", "name": "spc-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10515357", "map_id": "Q21408", "name": "spc-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10515355", "map_id": "Q21408", "name": "spc-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10572369", "map_id": "none", "name": "HEXB cleaves the terminal GalNAc from small HA fragments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_2162223", "map_id": "none", "name": "GlcNAc-GlcA-GlcNAc", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_1678743", "map_id": "CHEBI:17411", "name": "GlcNAc", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_2162224", "map_id": "CHEBI:64024", "name": "GlcA-\u03b21,3-GlcNAc", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10536355", "map_id": "none", "name": "bHEXB", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "true" }, { "id": "Q22492", "map_id": "Q22492", "name": "hex-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020509", "map_id": "WBGene00020509", "name": "hex-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10543041", "map_id": "none", "name": "HEXA cleaves the terminal GalNAc from small HA fragments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_10536342", "map_id": "none", "name": "HEXA", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "true" }, { "id": "reaction_10543043", "map_id": "none", "name": "GUSB tetramer hydrolyses GlcA-1,3-GlcNAc", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_1678868", "map_id": "CHEBI:4178", "name": "GlcA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_10537432", "map_id": "none", "name": "GUSB tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "true" }, { "id": "Q95Q32", "map_id": "Q95Q32", "name": "GUSB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013693", "map_id": "WBGene00013693", "name": "GUSB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10543045", "map_id": "none", "name": "GUSB tetramer hydrolyses (HA)2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_2160866", "map_id": "none", "name": "(HA)2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "true" }, { "id": "reaction_10542936", "map_id": "none", "name": "HYAL1 hydrolyses (HA)50", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_2160864", "map_id": "none", "name": "(HA)50", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "true" }, { "id": "species_10537452", "map_id": "G5ECE8", "name": "chhy-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "WBGene00011923", "map_id": "WBGene00011923", "name": "chhy-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10542957", "map_id": "none", "name": "Hyaluronidase 2 (HYAL2) hydrolyses HA into 20kDa fragments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10542954", "map_id": "none", "name": "HA:HAR:HYAL2:SLC9A1:pCHP:Ca2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q23643", "map_id": "Q23643", "name": "phospho-chpf-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00014109", "map_id": "WBGene00014109", "name": "phospho-chpf-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P35449", "map_id": "P35449", "name": "nhx-9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003736", "map_id": "WBGene00003736", "name": "nhx-9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EDU2", "map_id": "G5EDU2", "name": "nhx-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003732", "map_id": "WBGene00003732", "name": "nhx-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8T5S1", "map_id": "Q8T5S1", "name": "nhx-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003730", "map_id": "WBGene00003730", "name": "nhx-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "H2L039", "map_id": "H2L039", "name": "nhx-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003734", "map_id": "WBGene00003734", "name": "nhx-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O16452", "map_id": "O16452", "name": "nhx-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003731", "map_id": "WBGene00003731", "name": "nhx-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5ECE8", "map_id": "G5ECE8", "name": "chhy-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_2160894", "map_id": "none", "name": "(HA)50", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10502580", "map_id": "none", "name": "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_30187", "map_id": "CHEBI:18077", "name": "dTTP", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_30185", "map_id": "CHEBI:16311", "name": "dCTP", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10502151", "map_id": "none", "name": "RNA primer:origin duplex:DNA polymerase alpha:primase complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "C7IVS4", "map_id": "C7IVS4", "name": "pola-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012936", "map_id": "WBGene00012936", "name": "pola-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34471", "map_id": "P34471", "name": "pri-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004180", "map_id": "WBGene00004180", "name": "pri-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O02334", "map_id": "O02334", "name": "pri-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004181", "map_id": "WBGene00004181", "name": "pri-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q21625", "map_id": "Q21625", "name": "div-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001002", "map_id": "WBGene00001002", "name": "div-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_29892", "map_id": "CHEBI:16497", "name": "dGTP", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_29604", "map_id": "CHEBI:16284", "name": "dATP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10502577", "map_id": "none", "name": "RNA primer-DNA primer:origin duplex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10502123", "map_id": "none", "name": "DNA polymerase alpha:primase", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10502154", "map_id": "none", "name": "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10502149", "map_id": "none", "name": "DNA polymerase alpha:primase:DNA polymerase alpha:origin complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "O62218", "map_id": "O62218", "name": "pole-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009368", "map_id": "WBGene00009368", "name": "pole-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q19196", "map_id": "Q19196", "name": "pole-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017237", "map_id": "WBGene00017237", "name": "pole-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q22798", "map_id": "Q22798", "name": "POLE3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020823", "map_id": "WBGene00020823", "name": "POLE3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9NAC5", "map_id": "Q9NAC5", "name": "pole-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013150", "map_id": "WBGene00013150", "name": "pole-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_30595", "map_id": "none", "name": "NTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_110614", "map_id": "CHEBI:17677", "name": "CTP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10502145", "map_id": "none", "name": "DNA polymerase epsilon", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10502343", "map_id": "none", "name": "Phosphorylated Orc1 is ubiquitinated while still associated with chromatin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10502250", "map_id": "Q9XX17", "name": "phospho-orc-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00012650", "map_id": "WBGene00012650", "name": "orc-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10502321", "map_id": "Q9XX17", "name": "phospho-orc-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10502340", "map_id": "none", "name": "SCF (SKP2) complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10502281", "map_id": "none", "name": "Orc1 is phosphorylated by cyclin A/CDK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10502240", "map_id": "none", "name": "pre-replicative complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "O16297", "map_id": "O16297", "name": "mcm-7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003159", "map_id": "WBGene00003159", "name": "mcm-7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q95XQ8", "map_id": "Q95XQ8", "name": "mcm-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003156", "map_id": "WBGene00003156", "name": "mcm-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XXI9", "map_id": "Q9XXI9", "name": "mcm-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003154", "map_id": "WBGene00003154", "name": "mcm-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q21902", "map_id": "Q21902", "name": "mcm-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003157", "map_id": "WBGene00003157", "name": "mcm-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34647", "map_id": "P34647", "name": "mcm-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003158", "map_id": "WBGene00003158", "name": "mcm-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XVR7", "map_id": "Q9XVR7", "name": "mcm-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003155", "map_id": "WBGene00003155", "name": "mcm-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XX16", "map_id": "Q9XX16", "name": "orc-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012651", "map_id": "WBGene00012651", "name": "orc-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q23249", "map_id": "Q23249", "name": "orc-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013857", "map_id": "WBGene00013857", "name": "orc-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XX17", "map_id": "Q9XX17", "name": "orc-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q21037", "map_id": "Q21037", "name": "orc-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003882", "map_id": "WBGene00003882", "name": "orc-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P91155", "map_id": "P91155", "name": "cdc-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000382", "map_id": "WBGene00000382", "name": "cdc-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86S68", "map_id": "Q86S68", "name": "cdt-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000413", "map_id": "WBGene00000413", "name": "cdt-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10502252", "map_id": "none", "name": "pre-replicative complex (Orc1-minus)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10502347", "map_id": "none", "name": "Ubiquitinated Orc1 enters the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10502345", "map_id": "Q9XX17", "name": "phospho-orc-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10502575", "map_id": "none", "name": "Ubiquitinated Orc1 is degraded by the proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10502611", "map_id": "none", "name": "Ubiquitinated Cdc6 is degraded by the proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10502609", "map_id": "none", "name": "ubiquitinated Cdc6", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10502601", "map_id": "none", "name": "Cdc6 protein is phosphorylated by CDK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10502084", "map_id": "P91155", "name": "cdc-6", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10502587", "map_id": "P91155", "name": "phospho-cdc-6", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10502598", "map_id": "none", "name": "CCNA:p-T160-CDK2,CCNE:p-T160-CDK2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "O01501", "map_id": "O01501", "name": "cye-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000871", "map_id": "WBGene00000871", "name": "cye-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10502605", "map_id": "none", "name": "Phosphorylated Cdc6 is exported from the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10502603", "map_id": "P91155", "name": "phospho-cdc-6", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10502615", "map_id": "none", "name": "Mcm4,6,7 trimer forms and associates with the replication fork", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10502216", "map_id": "none", "name": "MCM2-7", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10502189", "map_id": "Q9XVR7", "name": "mcm-3", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10502199", "map_id": "Q21902", "name": "mcm-5", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10502214", "map_id": "Q9XXI9", "name": "mcm-2", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10502613", "map_id": "none", "name": "Mcm4,6,7 complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10512052", "map_id": "none", "name": "Formation of GINS complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10512043", "map_id": "Q9BL54", "name": "psf-3", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00022043", "map_id": "WBGene00022043", "name": "psf-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10512038", "map_id": "O62193", "name": "psf-2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00009287", "map_id": "WBGene00009287", "name": "psf-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10512033", "map_id": "Q22019", "name": "psf-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00011275", "map_id": "WBGene00011275", "name": "psf-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10512048", "map_id": "Q9U2W9", "name": "sld-5", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00013768", "map_id": "WBGene00013768", "name": "sld-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10512050", "map_id": "none", "name": "GINS complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9U2W9", "map_id": "Q9U2W9", "name": "sld-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q22019", "map_id": "Q22019", "name": "psf-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O62193", "map_id": "O62193", "name": "psf-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9BL54", "map_id": "Q9BL54", "name": "psf-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10502657", "map_id": "none", "name": "Loading of PCNA - Sliding Clamp Formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10502653", "map_id": "none", "name": "PCNA homotrimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10502644", "map_id": "none", "name": "RFC Heteropentamer:RNA primer-DNA primer:origin duplex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10502655", "map_id": "none", "name": "RFC Heteropentamer:RNA primer-DNA primer:origin duplex:PCNA homotrimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10502661", "map_id": "none", "name": "RFC dissociates after sliding clamp formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10502659", "map_id": "none", "name": "RNA primer-DNA primer:origin duplex:PCNA ", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10502642", "map_id": "none", "name": "RFC Heteropentamer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10502646", "map_id": "none", "name": "RFC binding displaces Pol Alpha", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10502684", "map_id": "none", "name": "Formation of Processive Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10502680", "map_id": "none", "name": "DNA Polymerase delta tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10502682", "map_id": "none", "name": "Processive complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10502727", "map_id": "none", "name": "Removal of remaining Flap", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10502717", "map_id": "none", "name": "Processive complex:Okazaki fragments:Remaining Flap", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10502719", "map_id": "none", "name": "Processive complex:nicked DNA from adjacent Okazaki fragments", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10502724", "map_id": "Q9N3T2", "name": "crn-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10502715", "map_id": "none", "name": "Recruitment of Dna2 endonuclease", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10502711", "map_id": "Q9U3F2", "name": "dna-2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00001016", "map_id": "WBGene00001016", "name": "dna-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10502706", "map_id": "none", "name": "Processive complex:Okazaki fragment:Flap:RPA heterotrimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10502713", "map_id": "none", "name": "Processive complex:Okazaki fragment:Flap:RPA heterotrimer:dna2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9U3F2", "map_id": "Q9U3F2", "name": "dna-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10502689", "map_id": "none", "name": "Formation of Okazaki fragments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10502686", "map_id": "none", "name": "Processive complex:Okazaki fragment complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10502693", "map_id": "none", "name": "Formation of the Flap Intermediate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10502691", "map_id": "none", "name": "Processive complex:Okazaki fragment:Flap", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10502735", "map_id": "none", "name": "Joining of adjacent Okazaki fragments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_68452", "map_id": "none", "name": "Okazaki fragment", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_69172", "map_id": "none", "name": "ligated okazaki fragment", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10544506", "map_id": "none", "name": "Acetylation of SMC3 subunit of chromosomal arm associated cohesin by ESCO1 or ESCO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10544486", "map_id": "none", "name": "Cohesin:PDS5:WAPAL:Chromosomal Arm", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "H2L0H5", "map_id": "H2L0H5", "name": "wapl-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019953", "map_id": "WBGene00019953", "name": "wapl-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "B2FDA8", "map_id": "B2FDA8", "name": "smc-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004873", "map_id": "WBGene00004873", "name": "smc-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q19325", "map_id": "Q19325", "name": "phospho-scc-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004737", "map_id": "WBGene00004737", "name": "phospho-scc-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XUB3", "map_id": "Q9XUB3", "name": "phospho-rec-8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004333", "map_id": "WBGene00004333", "name": "phospho-rec-8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q19555", "map_id": "Q19555", "name": "phospho-scc-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004738", "map_id": "WBGene00004738", "name": "phospho-scc-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O01789", "map_id": "O01789", "name": "him-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001860", "map_id": "WBGene00001860", "name": "him-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EC05", "map_id": "G5EC05", "name": "evl-14", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001352", "map_id": "WBGene00001352", "name": "evl-14", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10544494", "map_id": "none", "name": "Ac-Cohesin:PDS5:WAPAL:Chromosomal Arm", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10544503", "map_id": "none", "name": "ESCO", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q19206", "map_id": "Q19206", "name": "ESCO2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017269", "map_id": "WBGene00017269", "name": "ESCO2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10544558", "map_id": "none", "name": "Acetylation of SMC3 subunit of centromeric chromatin associated cohesin by ESCO1 or ESCO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10544554", "map_id": "none", "name": "Cohesin:PDS5:WAPAL:Centromere", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10544556", "map_id": "none", "name": "Ac-Cohesin:PDS5:WAPAL:Centromere", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10511601", "map_id": "none", "name": "Formation of Cyclin A:Cdk2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10511204", "map_id": "none", "name": "CCNA", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10502737", "map_id": "O61847", "name": "cdk-2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10511599", "map_id": "none", "name": "CCNA:CDK2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10513907", "map_id": "none", "name": "AKT phosphorylates p21Cip1 and p27Kip1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10512493", "map_id": "G5EEJ2", "name": "cki-2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10513904", "map_id": "G5EEJ2", "name": "phospho-cki-2", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10513848", "map_id": "none", "name": "p-T,p-S-AKT", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10512676", "map_id": "none", "name": "Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10512678", "map_id": "none", "name": "CAK-mediated phosphorylation of Cyclin A:Cdk2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10506279", "map_id": "none", "name": "CAK", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10511719", "map_id": "none", "name": "Translocation of Cyclin A:Cdk2 complexes to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13231", "compartment_display": "nuclear envelope" }, { "id": "reaction_10512609", "map_id": "none", "name": "Degradation of ubiquitinated p27/p21 by the 26S proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10512520", "map_id": "none", "name": "Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B:3xubiquitin", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q17868", "map_id": "Q17868", "name": "cks-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001051", "map_id": "WBGene00001051", "name": "cks-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10512514", "map_id": "none", "name": "CUL1:SKP1:SKP2:CKS1B", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10512612", "map_id": "none", "name": "Ubiquitination of phospho-p27/p21", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10512516", "map_id": "none", "name": "Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10512518", "map_id": "none", "name": "Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10512502", "map_id": "none", "name": "Cyclin E/A:p-T160-CDK2:p-S130-CDKN1A,p-T187-CDKN1B", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10512505", "map_id": "none", "name": "Cyclin E/A:Cdk2-mediated phosphorylation of p27/p21", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10512497", "map_id": "none", "name": "Cyclin E/A:p-T160-CDK2:CDKN1A,CDKN1B", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10512668", "map_id": "none", "name": "Cyclin A:Cdk2 mediated phosphorylation of p27/p21", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10512665", "map_id": "none", "name": "Cyclin A:Cdk2:phospho-p27/p21 complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10512495", "map_id": "none", "name": "Translocation of p27 to the nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13231", "compartment_display": "nuclear envelope" }, { "id": "reaction_10511615", "map_id": "none", "name": "Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10511611", "map_id": "none", "name": "CCNA:p-Y15-CDK2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10502759", "map_id": "Q21762", "name": "cdc-25.4", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00000389", "map_id": "WBGene00000389", "name": "cdc-25.4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10511365", "map_id": "none", "name": "Adenylate cyclase increases the GTPase activity of Gi alpha", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10511333", "map_id": "none", "name": "(Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q7KPV0", "map_id": "Q7KPV0", "name": "gsa-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001745", "map_id": "WBGene00001745", "name": "gsa-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "V6CLB7", "map_id": "V6CLB7", "name": "gpa-18", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020997", "map_id": "WBGene00020997", "name": "gpa-18", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O76584", "map_id": "O76584", "name": "gpa-11", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001673", "map_id": "WBGene00001673", "name": "gpa-11", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9BIG5", "map_id": "Q9BIG5", "name": "gpa-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001666", "map_id": "WBGene00001666", "name": "gpa-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q21917", "map_id": "Q21917", "name": "gpa-7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001669", "map_id": "WBGene00001669", "name": "gpa-7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P91907", "map_id": "P91907", "name": "gpa-15", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001677", "map_id": "WBGene00001677", "name": "gpa-15", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q93743", "map_id": "Q93743", "name": "gpa-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001668", "map_id": "WBGene00001668", "name": "gpa-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q20907", "map_id": "Q20907", "name": "gpa-8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001670", "map_id": "WBGene00001670", "name": "gpa-8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9BIG2", "map_id": "Q9BIG2", "name": "gpa-14", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001676", "map_id": "WBGene00001676", "name": "gpa-14", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q20910", "map_id": "Q20910", "name": "gpa-9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001671", "map_id": "WBGene00001671", "name": "gpa-9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10511351", "map_id": "none", "name": "(Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10511353", "map_id": "none", "name": "Dissociation of the Gi alpha:G olf complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10511335", "map_id": "none", "name": "G alpha-olf:GDP complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10511349", "map_id": "none", "name": "G-protein alpha (i):GDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10511340", "map_id": "none", "name": "Adenylate cyclase increases the GTPase activity of G alpha-olf", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10511337", "map_id": "none", "name": "(Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GDP)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10511342", "map_id": "none", "name": "G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10511331", "map_id": "none", "name": "G-protein alpha (i):GTP:Adenylate cyclase", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10511283", "map_id": "none", "name": "G alpha-olf:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10511360", "map_id": "none", "name": "The G alpha-olf:GDP:Adenylate cyclase complex dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10511358", "map_id": "none", "name": "G alpha-olf:GDP:Adenylate cyclase (active) complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10511347", "map_id": "none", "name": "Galpha-olf:GTP binds to adenylate cyclase and activates it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10511344", "map_id": "none", "name": "G alpha-olf:GTP:Adenylate cyclase (active) complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10511363", "map_id": "none", "name": "Adenylaye cyclase increases the GTPase activity of G alpha-olf", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10511356", "map_id": "none", "name": "Adenylate cyclase converts ATP into cyclic AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10509072", "map_id": "none", "name": "Inactivation of PLC beta", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10508939", "map_id": "none", "name": "Activated PLC beta 1/4", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "G5EBH0", "map_id": "G5EBH0", "name": "egl-8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001177", "map_id": "WBGene00001177", "name": "egl-8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EGU1", "map_id": "G5EGU1", "name": "egl-30", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001196", "map_id": "WBGene00001196", "name": "egl-30", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9N4F4", "map_id": "Q9N4F4", "name": "gpa-17", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022196", "map_id": "WBGene00022196", "name": "gpa-17", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10509070", "map_id": "none", "name": "G-protein alpha:GDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10508913", "map_id": "G5EBH0", "name": "egl-8", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10508942", "map_id": "none", "name": "PIP2 hydrolysis", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_112275", "map_id": "CHEBI:18035", "name": "DAGs", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10509032", "map_id": "none", "name": "PDE4A,C,D hydrolyse cAMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10509025", "map_id": "Q22000", "name": "pde-4", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00020114", "map_id": "WBGene00020114", "name": "pde-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10572525", "map_id": "none", "name": "p-S54-PDE4B hydrolyses cAMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10512059", "map_id": "Q22000", "name": "phospho-pde-4", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10512062", "map_id": "none", "name": "PKA phosphorylates PDE4B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10512056", "map_id": "Q22000", "name": "pde-4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10510834", "map_id": "none", "name": "The receptor:G-protein complex binds GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10510829", "map_id": "none", "name": "Opioid:MOR:G-protein complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q20841", "map_id": "Q20841", "name": "npr-28", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018886", "map_id": "WBGene00018886", "name": "npr-28", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "H9G358", "map_id": "H9G358", "name": "SSTR3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018089", "map_id": "WBGene00018089", "name": "SSTR3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A0K3AXD3", "map_id": "A0A0K3AXD3", "name": "npr-26", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011372", "map_id": "WBGene00011372", "name": "npr-26", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q23033", "map_id": "Q23033", "name": "npr-24", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020086", "map_id": "WBGene00020086", "name": "npr-24", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34311", "map_id": "P34311", "name": "SSTR3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A2C9C3A4", "map_id": "A0A2C9C3A4", "name": "SSTR3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XVQ0", "map_id": "Q9XVQ0", "name": "SSTR3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q09502", "map_id": "Q09502", "name": "npr-18", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008065", "map_id": "WBGene00008065", "name": "npr-18", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A3B1DQQ4", "map_id": "A0A3B1DQQ4", "name": "npr-16", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006864", "map_id": "WBGene00006864", "name": "npr-16", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P17343", "map_id": "P17343", "name": "gpb-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001679", "map_id": "WBGene00001679", "name": "gpb-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P54406", "map_id": "P54406", "name": "gpc-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001681", "map_id": "WBGene00001681", "name": "gpc-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10509169", "map_id": "none", "name": "Opioid:MOR:G protein-GTP complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10508935", "map_id": "none", "name": "G-protein alpha (q/11/14/15)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10510836", "map_id": "none", "name": "G-protein beta-gamma subunits rebind the alpha-GDP subunit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_947587", "compartment_display": "cytoplasmic side of plasma membrane" }, { "id": "species_10509165", "map_id": "none", "name": "G-protein beta-gamma complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10510817", "map_id": "none", "name": "G protein-GDP complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10510831", "map_id": "none", "name": "The receptor:G-protein complex releases GDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10510819", "map_id": "none", "name": "Opioid:MOR:G protein-GDP complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10510815", "map_id": "none", "name": "G-protein alpha subunit is inactivated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_947587", "compartment_display": "cytoplasmic side of plasma membrane" }, { "id": "species_10508937", "map_id": "none", "name": "G protein alpha:GTP complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10524194", "map_id": "none", "name": "NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_172574", "compartment_display": "late endosome membrane" }, { "id": "species_445829", "map_id": "none", "name": "Divalent metals transported by NRAMP1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_445832", "map_id": "none", "name": "Divalent metals transported by NRAMP1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_1222282", "compartment_display": "phagocytic vesicle lumen", "complex": "true" }, { "id": "species_1470067", "map_id": "CHEBI:15378", "name": "H+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_1222282", "compartment_display": "phagocytic vesicle lumen", "complex": "false" }, { "id": "species_10524191", "map_id": "none", "name": "Homologues of SLC11A1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_172574", "compartment_display": "late endosome membrane", "complex": "true" }, { "id": "Q21433", "map_id": "Q21433", "name": "smf-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004877", "map_id": "WBGene00004877", "name": "smf-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q21434", "map_id": "Q21434", "name": "smf-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004876", "map_id": "WBGene00004876", "name": "smf-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q95XG8", "map_id": "Q95XG8", "name": "smf-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004878", "map_id": "WBGene00004878", "name": "smf-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10532076", "map_id": "none", "name": "Intraphagosomal pH is lowered to 5 by V-ATPase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_1222693", "compartment_display": "phagocytic vesicle membrane" }, { "id": "species_10532073", "map_id": "none", "name": "V-ATPase", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_1222693", "compartment_display": "phagocytic vesicle membrane", "complex": "true" }, { "id": "Q9XXU9", "map_id": "Q9XXU9", "name": "vha-11", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006920", "map_id": "WBGene00006920", "name": "vha-11", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q22494", "map_id": "Q22494", "name": "vha-15", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020507", "map_id": "WBGene00020507", "name": "vha-15", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q23680", "map_id": "Q23680", "name": "vha-9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006918", "map_id": "WBGene00006918", "name": "vha-9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34462", "map_id": "P34462", "name": "vha-14", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010130", "map_id": "WBGene00010130", "name": "vha-14", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XW92", "map_id": "Q9XW92", "name": "vha-13", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013025", "map_id": "WBGene00013025", "name": "vha-13", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q19626", "map_id": "Q19626", "name": "vha-12", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006921", "map_id": "WBGene00006921", "name": "vha-12", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9N5A0", "map_id": "Q9N5A0", "name": "spe-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004959", "map_id": "WBGene00004959", "name": "spe-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q95X44", "map_id": "Q95X44", "name": "vha-8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006917", "map_id": "WBGene00006917", "name": "vha-8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P91303", "map_id": "P91303", "name": "vha-10", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006919", "map_id": "WBGene00006919", "name": "vha-10", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EDB8", "map_id": "G5EDB8", "name": "vha-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006913", "map_id": "WBGene00006913", "name": "vha-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q20591", "map_id": "Q20591", "name": "vha-17", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009882", "map_id": "WBGene00009882", "name": "vha-17", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "C0HLB3", "map_id": "C0HLB3", "name": "vha-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006911", "map_id": "WBGene00006911", "name": "vha-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "C0HLB4", "map_id": "C0HLB4", "name": "vha-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006912", "map_id": "WBGene00006912", "name": "vha-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P30628", "map_id": "P30628", "name": "unc-32", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006768", "map_id": "WBGene00006768", "name": "unc-32", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "B2MZD0", "map_id": "B2MZD0", "name": "vha-7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006916", "map_id": "WBGene00006916", "name": "vha-7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EEK9", "map_id": "G5EEK9", "name": "vha-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006914", "map_id": "WBGene00006914", "name": "vha-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EGP4", "map_id": "G5EGP4", "name": "vha-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006915", "map_id": "WBGene00006915", "name": "vha-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q95YD5", "map_id": "Q95YD5", "name": "vha-16", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016258", "map_id": "WBGene00016258", "name": "vha-16", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10558402", "map_id": "none", "name": "Membrane-bound myeloperoxidase (MPO) produces hypochlorous acid (HOCl)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_21994", "compartment_display": "phagocytic vesicle" }, { "id": "species_1222719", "map_id": "CHEBI:16240", "name": "H2O2", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_1222282", "compartment_display": "phagocytic vesicle lumen", "complex": "false" }, { "id": "species_6788973", "map_id": "CHEBI:17996", "name": "Cl-", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_1222282", "compartment_display": "phagocytic vesicle lumen", "complex": "false" }, { "id": "species_1222475", "map_id": "CHEBI:15377", "name": "H2O", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_1222282", "compartment_display": "phagocytic vesicle lumen", "complex": "false" }, { "id": "species_6789150", "map_id": "CHEBI:24757", "name": "HOCl", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_1222282", "compartment_display": "phagocytic vesicle lumen", "complex": "false" }, { "id": "species_10558399", "map_id": "none", "name": "MPO:ferriheme:bacterial cell surface", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_1222282", "compartment_display": "phagocytic vesicle lumen", "complex": "true" }, { "id": "P91060", "map_id": "P91060", "name": "skpo-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00015841", "map_id": "WBGene00015841", "name": "skpo-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q1ENI8", "map_id": "Q1ENI8", "name": "pxn-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004256", "map_id": "WBGene00004256", "name": "pxn-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q20616", "map_id": "Q20616", "name": "skpo-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009897", "map_id": "WBGene00009897", "name": "skpo-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q23490", "map_id": "Q23490", "name": "mlt-7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022743", "map_id": "WBGene00022743", "name": "mlt-7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EG78", "map_id": "G5EG78", "name": "pxn-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004257", "map_id": "WBGene00004257", "name": "pxn-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "H2KZ53", "map_id": "H2KZ53", "name": "skpo-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017968", "map_id": "WBGene00017968", "name": "skpo-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:55376", "map_id": "CHEBI:55376", "name": "CHEBI:55376", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10558405", "map_id": "none", "name": "Myeloperoxidase (MPO) produces hypochlorous acid (HOCl)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_1222282", "compartment_display": "phagocytic vesicle lumen" }, { "id": "species_10558397", "map_id": "none", "name": "MPO:ferriheme", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_1222282", "compartment_display": "phagocytic vesicle lumen", "complex": "true" }, { "id": "reaction_10568119", "map_id": "none", "name": "Myeloperoxidase (MPO) catalyzes oxidation of nitrite to nitrogen dioxide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_1222282", "compartment_display": "phagocytic vesicle lumen" }, { "id": "species_6789221", "map_id": "CHEBI:16301", "name": "nitrite", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_1222282", "compartment_display": "phagocytic vesicle lumen", "complex": "false" }, { "id": "species_8933637", "map_id": "CHEBI:33101", "name": "NO2", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_1222282", "compartment_display": "phagocytic vesicle lumen", "complex": "false" }, { "id": "reaction_10558407", "map_id": "none", "name": "Myeloperoxidase (MPO) binds to the bacterial cell surface", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_21994", "compartment_display": "phagocytic vesicle" }, { "id": "species_983438", "map_id": "none", "name": "Cell surface", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10565654", "map_id": "none", "name": "Lactoperoxidase (LPO) produces OSCN-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_351629", "map_id": "CHEBI:16240", "name": "H2O2", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_8855492", "map_id": "CHEBI:18022", "name": "SCN(-)", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_8855489", "map_id": "CHEBI:133907", "name": "OSCN-", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10565651", "map_id": "none", "name": "LPO:ferriheme", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10573254", "map_id": "none", "name": "AKT phosphorylates FOXO3 downstream of FLT3 ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10514276", "map_id": "O16850", "name": "daf-16", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00000912", "map_id": "WBGene00000912", "name": "daf-16", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10514290", "map_id": "O16850", "name": "phospho-daf-16", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10514266", "map_id": "none", "name": "p-T,p-S-AKT", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10571976", "map_id": "none", "name": "SOS1-mediated nucleotide exchange of RAS downstream of FLT3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10554987", "map_id": "none", "name": "Active FLT3:GRB2:SOS1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10573256", "map_id": "none", "name": "AKT-phosphorylated FOXO3 translocates to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10572151", "map_id": "O16850", "name": "phospho-daf-16", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10573245", "map_id": "none", "name": "Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10508492", "map_id": "none", "name": "Active FLT3:GRB2:p-Y-GAB2:PIK3R1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10543896", "map_id": "none", "name": "Active FLT3:GRB2:p-Y GAB2:PI3K", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10573264", "map_id": "none", "name": "PDE3B hydrolyses cAMP to AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10573261", "map_id": "Q8I0P7", "name": "pde-3", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00008443", "map_id": "WBGene00008443", "name": "phospho-pde-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10572293", "map_id": "none", "name": "PDE3A hydrolyses cAMP to AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10572290", "map_id": "Q8I0P7", "name": "pde-3", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10573321", "map_id": "none", "name": "PDE4A hydrolyses cAMP to AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10521818", "map_id": "none", "name": "cAMP degradation by Phosphodiesterases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10521815", "map_id": "none", "name": "cAMP PDEs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q22000", "map_id": "Q22000", "name": "pde-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9N2V9", "map_id": "Q9N2V9", "name": "pde-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022389", "map_id": "WBGene00022389", "name": "pde-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P30645", "map_id": "P30645", "name": "pde-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011146", "map_id": "WBGene00011146", "name": "pde-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P91119", "map_id": "P91119", "name": "pde-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016328", "map_id": "WBGene00016328", "name": "pde-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10571834", "map_id": "none", "name": "PIP3 recruits PDK1 and AKT to the membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10515193", "map_id": "Q9UA62", "name": "PDPK1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10520802", "map_id": "none", "name": "AKT", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10571832", "map_id": "none", "name": "PDK1:AKT:PIP3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10521037", "map_id": "none", "name": "G beta:gamma activated PI3Kgamma converts PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10521034", "map_id": "none", "name": "G-protein beta-gamma:PI3K gamma", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10570240", "map_id": "none", "name": "CDC42 binds GNB/GNG:PAK1:ARHGEF6 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10570223", "map_id": "none", "name": "G-protein beta-gamma complex:Active PAK1:ARHGEF6", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q21430", "map_id": "Q21430", "name": "pix-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010776", "map_id": "WBGene00010776", "name": "pix-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EGQ3", "map_id": "G5EGQ3", "name": "max-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003144", "map_id": "WBGene00003144", "name": "max-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q17850", "map_id": "Q17850", "name": "phospho-pak-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003911", "map_id": "WBGene00003911", "name": "phospho-pak-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10512277", "map_id": "Q05062", "name": "cdc-42", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "WBGene00000390", "map_id": "WBGene00000390", "name": "cdc-42", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10570229", "map_id": "none", "name": "G-protein beta-gamma complex:PAK1:ARHGEF6:CDC42", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q05062", "map_id": "Q05062", "name": "cdc-42", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10570227", "map_id": "none", "name": "Active PAK1 and Active CDC42 dissociates from GNB/GNG:PAK1:ARHGEF6:CDC42 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10570225", "map_id": "none", "name": "G-protein beta-gamma complex:Active PAK1:ARHGEF6:Active CDC42", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10520670", "map_id": "none", "name": "Homologues of PAK1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10516119", "map_id": "Q21430", "name": "pix-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10512279", "map_id": "none", "name": "CDC42:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10570232", "map_id": "none", "name": "CDC42 in GNB/GNG:PAK1:ARHGEF6:CDC42 is activated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10570234", "map_id": "none", "name": "PAK1:ARHGEF6 complex binds G-protein beta-gamma complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10570221", "map_id": "none", "name": "Active PAK1:ARHGEF6", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10570236", "map_id": "none", "name": "PAK1 in GNB/GNG:PAK1:ARHGEF6:Active CDC42 is activated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10570238", "map_id": "none", "name": "PAK1 binds ARHGEF6", "reversible": "false", "notes": "", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10528036", "map_id": "none", "name": "Inactive G alpha (i) reassociates with G beta:gamma", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10519835", "map_id": "none", "name": "Heterotrimeric G-protein Gi (inactive)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10570486", "map_id": "none", "name": "Active G alpha (i)i1/i2/i3 binds RGS proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10570468", "map_id": "none", "name": "RGS1,3,4,5,6,7,8,9,10,11,12,13,14,16,17,18,19,20,21", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q18563", "map_id": "Q18563", "name": "rgs-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004349", "map_id": "WBGene00004349", "name": "rgs-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5ECK9", "map_id": "G5ECK9", "name": "rgs-8.1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004351", "map_id": "WBGene00004351", "name": "rgs-8.1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q23376", "map_id": "Q23376", "name": "rgs-9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004352", "map_id": "WBGene00004352", "name": "rgs-9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O45523", "map_id": "O45523", "name": "rgs-10", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004353", "map_id": "WBGene00004353", "name": "rgs-10", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8WQC0", "map_id": "Q8WQC0", "name": "rgs-7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004350", "map_id": "WBGene00004350", "name": "rgs-7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O45524", "map_id": "O45524", "name": "rgs-11", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004354", "map_id": "WBGene00004354", "name": "rgs-11", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P49808", "map_id": "P49808", "name": "rgs-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004345", "map_id": "WBGene00004345", "name": "rgs-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P49809", "map_id": "P49809", "name": "egl-10", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001179", "map_id": "WBGene00001179", "name": "egl-10", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A5S9MNH1", "map_id": "A0A5S9MNH1", "name": "rgs-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004347", "map_id": "WBGene00004347", "name": "rgs-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O17589", "map_id": "O17589", "name": "eat-16", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001145", "map_id": "WBGene00001145", "name": "eat-16", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10511329", "map_id": "none", "name": "G alpha (i): GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10570484", "map_id": "none", "name": "G alpha (i):GTP:RGS", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10570217", "map_id": "none", "name": "G protein alpha (i)-SRC complex catalyzes SRC to p-Y416-SRC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10570204", "map_id": "none", "name": "G alpha (i):GTP:SRC-1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10570214", "map_id": "none", "name": "G protein alpha (i):GTP:p-Y416-SRC", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10570489", "map_id": "none", "name": "G alpha (i)i1/i2/i3 in G (i):RGS complex is inactivated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10570470", "map_id": "none", "name": "G alpha (i):GDP:RGS", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10570472", "map_id": "none", "name": "G alpha (i):RGS dissociates to inactive G alpha (i)i1/i2/i3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10570219", "map_id": "none", "name": "G protein alpha (i)-SRC complex dissociates to G protein alpha (i) and Active SRC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10570212", "map_id": "none", "name": "Homologues of p-Y416-SRC", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10519851", "map_id": "none", "name": "Liganded Gi-activating GPCR acts as a GEF for Gi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_947587", "compartment_display": "cytoplasmic side of plasma membrane" }, { "id": "species_10519837", "map_id": "none", "name": "Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_390899", "map_id": "CHEBI:18295", "name": "Hist", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "Q9U7D5", "map_id": "Q9U7D5", "name": "gar-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001519", "map_id": "WBGene00001519", "name": "gar-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_266074", "map_id": "CHEBI:28666", "name": "LTD4", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_266013", "map_id": "CHEBI:16978", "name": "LTC4", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "CHEBI:15650", "map_id": "CHEBI:15650", "name": "CHEBI:15650", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "H2KZ99", "map_id": "H2KZ99", "name": "gnrr-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016570", "map_id": "WBGene00016570", "name": "gnrr-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_879629", "map_id": "CHEBI:15555", "name": "PGD2", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "G5ECB2", "map_id": "G5ECB2", "name": "gbb-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022675", "map_id": "WBGene00022675", "name": "gbb-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "H2L0Q3", "map_id": "H2L0Q3", "name": "gbb-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021528", "map_id": "WBGene00021528", "name": "gbb-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_352003", "map_id": "CHEBI:59888", "name": "GABA", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "A1IMB8", "map_id": "A1IMB8", "name": "mgl-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021152", "map_id": "WBGene00021152", "name": "mgl-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q09630", "map_id": "Q09630", "name": "mgl-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003232", "map_id": "WBGene00003232", "name": "mgl-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7JP61", "map_id": "Q7JP61", "name": "octr-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006411", "map_id": "WBGene00006411", "name": "octr-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "E7EM37", "map_id": "E7EM37", "name": "dop-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001053", "map_id": "WBGene00001053", "name": "dop-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EGH0", "map_id": "G5EGH0", "name": "ser-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004779", "map_id": "WBGene00004779", "name": "ser-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_380585", "map_id": "CHEBI:28790", "name": "5HT", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_351601", "map_id": "CHEBI:18243", "name": "DA", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "Q6RYS9", "map_id": "Q6RYS9", "name": "dop-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020506", "map_id": "WBGene00020506", "name": "dop-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q10042", "map_id": "Q10042", "name": "ADORA2B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019287", "map_id": "WBGene00019287", "name": "ADORA2B", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q19295", "map_id": "Q19295", "name": "ADORA2B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q19779", "map_id": "Q19779", "name": "gtr-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017779", "map_id": "WBGene00017779", "name": "gtr-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q1ZXT2", "map_id": "Q1ZXT2", "name": "ador-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011878", "map_id": "WBGene00011878", "name": "ador-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10519841", "map_id": "none", "name": "Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10519847", "map_id": "Q19955", "name": "ags-3", "type": "inhibitor", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00000092", "map_id": "WBGene00000092", "name": "ags-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10528028", "map_id": "none", "name": "The Ligand:GPCR:Gi complex dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10519833", "map_id": "none", "name": "Ligand:GPCR complexes that activate Gi", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10528030", "map_id": "none", "name": "Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10570497", "map_id": "none", "name": "G alpha (q) in G (q):RGS complex is inactivated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10570476", "map_id": "none", "name": "G alpha (q):GTP:RGS", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10570494", "map_id": "none", "name": "G alpha (q):GDP:RGS", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10519681", "map_id": "none", "name": "Liganded Gq/11-activating GPCRs act as GEFs for Gq/11", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10519672", "map_id": "none", "name": "Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_266056", "map_id": "CHEBI:15647", "name": "LTB4", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "Q20325", "map_id": "Q20325", "name": "npr-27", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018344", "map_id": "WBGene00018344", "name": "npr-27", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XUK8", "map_id": "Q9XUK8", "name": "npr-14", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012275", "map_id": "WBGene00012275", "name": "npr-14", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P91096", "map_id": "P91096", "name": "dop-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016037", "map_id": "WBGene00016037", "name": "dop-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_417891", "map_id": "CHEBI:52288", "name": "LPA", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "G5EG10", "map_id": "G5EG10", "name": "mgl-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003233", "map_id": "WBGene00003233", "name": "mgl-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:28716", "map_id": "CHEBI:28716", "name": "CHEBI:28716", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:28875", "map_id": "CHEBI:28875", "name": "CHEBI:28875", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:53460", "map_id": "CHEBI:53460", "name": "CHEBI:53460", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:27997", "map_id": "CHEBI:27997", "name": "CHEBI:27997", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:16196", "map_id": "CHEBI:16196", "name": "CHEBI:16196", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_2066763", "map_id": "CHEBI:28125", "name": "DHA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "CHEBI:53487", "map_id": "CHEBI:53487", "name": "CHEBI:53487", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:53486", "map_id": "CHEBI:53486", "name": "CHEBI:53486", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_8934421", "map_id": "CHEBI:9254", "name": "STEA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "CHEBI:53488", "map_id": "CHEBI:53488", "name": "CHEBI:53488", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:28661", "map_id": "CHEBI:28661", "name": "CHEBI:28661", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:28364", "map_id": "CHEBI:28364", "name": "CHEBI:28364", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:27432", "map_id": "CHEBI:27432", "name": "CHEBI:27432", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O17899", "map_id": "O17899", "name": "pcdr-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010329", "map_id": "WBGene00010329", "name": "pcdr-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_158602", "map_id": "CHEBI:17659", "name": "UDP", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_419777", "map_id": "CHEBI:30212", "name": "Photon", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "P90745", "map_id": "P90745", "name": "npr-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007006", "map_id": "WBGene00007006", "name": "npr-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10519674", "map_id": "none", "name": "Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10519678", "map_id": "none", "name": "LTC4:CyslTR1,2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10528034", "map_id": "none", "name": "Inactive G alpha (q) reassociates with G beta:gamma", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10509557", "map_id": "none", "name": "G-protein alpha (q/11):GDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10509559", "map_id": "none", "name": "Heterotrimeric G-protein Gq/11 (inactive)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10570499", "map_id": "none", "name": "G alpha (q):RGS dissociates to inactive G alpha (q)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10570474", "map_id": "none", "name": "RGS1,2,3,4,5,13,16,17,18,19,21", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10521540", "map_id": "none", "name": "G alpha (q) binds to Trio family RhoGEFs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10521536", "map_id": "O61528", "name": "unc-73", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00006805", "map_id": "WBGene00006805", "name": "unc-73", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10521538", "map_id": "none", "name": "G-protein alpha (q/11):Trio family RhoGEFs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "O61528", "map_id": "O61528", "name": "unc-73", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10527910", "map_id": "none", "name": "Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10519670", "map_id": "none", "name": "Ligand:GPCR complexes that activate Gq/11", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_2514888", "compartment_display": "photoreceptor disc membrane", "complex": "true" }, { "id": "reaction_10543427", "map_id": "none", "name": "SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10543424", "map_id": "none", "name": "GRB2:SOS1:HB-EGF:p-6Y-EGFR", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10543444", "map_id": "none", "name": "Activated PKC-alpha activate MMP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10543441", "map_id": "none", "name": "Homologues of MMP3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "A0A0K3ARD1", "map_id": "A0A0K3ARD1", "name": "MMP9(107-707)", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00194737", "map_id": "WBGene00194737", "name": "MMP9(107-707)", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EBU3", "map_id": "G5EBU3", "name": "zmp-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016283", "map_id": "WBGene00016283", "name": "zmp-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5ECC4", "map_id": "G5ECC4", "name": "zmp-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020646", "map_id": "WBGene00020646", "name": "zmp-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EGM1", "map_id": "G5EGM1", "name": "zmp-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006987", "map_id": "WBGene00006987", "name": "zmp-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O62390", "map_id": "O62390", "name": "MMP9(107-707)", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q21182", "map_id": "Q21182", "name": "MMP9(107-707)", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10534164", "map_id": "none", "name": "Homologues of MMP3(100-477)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10521477", "map_id": "none", "name": "Diacylgycerol activates Protein kinase C, alpha type", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10509044", "map_id": "P90980", "name": "pkc-2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10570478", "map_id": "none", "name": "Active G alpha (q) binds RGS proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10528019", "map_id": "none", "name": "The Ligand:GPCR:Gq complex dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10527995", "map_id": "none", "name": "GPCRs that activate Gq/11", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_2514888", "compartment_display": "photoreceptor disc membrane", "complex": "true" }, { "id": "Q18701", "map_id": "Q18701", "name": "nmur-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016747", "map_id": "WBGene00016747", "name": "nmur-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O17239", "map_id": "O17239", "name": "nmur-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019616", "map_id": "WBGene00019616", "name": "nmur-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q18130", "map_id": "Q18130", "name": "NTSR2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016044", "map_id": "WBGene00016044", "name": "NTSR2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EDI0", "map_id": "G5EDI0", "name": "dcar-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007395", "map_id": "WBGene00007395", "name": "dcar-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O62403", "map_id": "O62403", "name": "npr-32", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013782", "map_id": "WBGene00013782", "name": "npr-32", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q03566", "map_id": "Q03566", "name": "tkr-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006576", "map_id": "WBGene00006576", "name": "tkr-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q95YD7", "map_id": "Q95YD7", "name": "trhr-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016265", "map_id": "WBGene00016265", "name": "trhr-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O44731", "map_id": "O44731", "name": "gnrr-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018798", "map_id": "WBGene00018798", "name": "gnrr-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10528017", "map_id": "none", "name": "Ligands of GPCRs that activate Gq/11", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_29444", "map_id": "CHEBI:32551", "name": "L-Lys", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_8869214", "map_id": "CHEBI:52450", "name": "PAF", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "G5EE40", "map_id": "G5EE40", "name": "srp-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00005642", "map_id": "WBGene00005642", "name": "srp-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EFH4", "map_id": "G5EFH4", "name": "srp-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00005647", "map_id": "WBGene00005647", "name": "srp-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O17365", "map_id": "O17365", "name": "srp-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00005643", "map_id": "WBGene00005643", "name": "srp-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q18287", "map_id": "Q18287", "name": "(Glc)3(GlcNAc)2(Man)9-SERPINA1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016187", "map_id": "WBGene00016187", "name": "(Glc)3(GlcNAc)2(Man)9-SERPINA1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q19651", "map_id": "Q19651", "name": "srp-8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00005649", "map_id": "WBGene00005649", "name": "srp-8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A9Z1L1", "map_id": "A9Z1L1", "name": "srp-7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00005648", "map_id": "WBGene00005648", "name": "srp-7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5ECY2", "map_id": "G5ECY2", "name": "srp-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00005644", "map_id": "WBGene00005644", "name": "srp-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_29460", "map_id": "CHEBI:30751", "name": "HCOOH", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "CHEBI:31011", "map_id": "CHEBI:31011", "name": "CHEBI:31011", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:30772", "map_id": "CHEBI:30772", "name": "CHEBI:30772", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_427486", "map_id": "CHEBI:15366", "name": "CH3COO-", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "CHEBI:30768", "map_id": "CHEBI:30768", "name": "CHEBI:30768", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:50122", "map_id": "CHEBI:50122", "name": "CHEBI:50122", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_33549", "map_id": "CHEBI:30805", "name": "DDCX", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "CHEBI:42504", "map_id": "CHEBI:42504", "name": "CHEBI:42504", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:6498", "map_id": "CHEBI:6498", "name": "CHEBI:6498", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q10651", "map_id": "Q10651", "name": "apl-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000149", "map_id": "WBGene00000149", "name": "apl-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:17120", "map_id": "CHEBI:17120", "name": "CHEBI:17120", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_209849", "map_id": "CHEBI:15765", "name": "L-Dopa", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "CHEBI:15627", "map_id": "CHEBI:15627", "name": "CHEBI:15627", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_879535", "map_id": "CHEBI:15553", "name": "PGF2a", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_265287", "map_id": "CHEBI:15551", "name": "PGE2", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10521878", "map_id": "none", "name": "G alpha (q) auto-inactivates by hydrolysing GTP to GDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10521876", "map_id": "none", "name": "RGS proteins active for G alpha (q)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10521559", "map_id": "none", "name": "G alpha (q) inhibits PI3K alpha", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10506892", "map_id": "none", "name": "PI3K", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10521557", "map_id": "none", "name": "G-protein alpha (q/11):PI3K alpha", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10509655", "map_id": "none", "name": "PLC-beta hydrolyses PIP2 to DAG and IP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10509650", "map_id": "none", "name": "PLC-beta:G-alpha(q/11):PIP2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10509652", "map_id": "none", "name": "PLC-beta:G-alpha(q/11):DAG:IP3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10521563", "map_id": "none", "name": "GRK2 sequesters activated Gq", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10521561", "map_id": "none", "name": "G-protein alpha (q):GRK2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10528032", "map_id": "none", "name": "Inactive G alpha (z) reassociates with G beta:gamma", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10527902", "map_id": "none", "name": "G-protein alpha (z):GDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10527904", "map_id": "none", "name": "Heterotrimeric G-protein Gz (inactive)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10570482", "map_id": "none", "name": "G alpha (z):RGS complex dissociates to give inactive G alpha (z)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10570480", "map_id": "none", "name": "G alpha (z):GDP:RGS16,17,20", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10570434", "map_id": "none", "name": "Homologues of RGS16", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10527908", "map_id": "none", "name": "Liganded Gz-activating GPCRs bind inactive heterotrimeric G-protein Gz", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10527906", "map_id": "none", "name": "Ligand:GPCR complexes that activate Gz:Heterotrimeric G-protein Gz (inactive)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10521015", "map_id": "none", "name": "G alpha (z) inhibits adenylate cyclase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10521011", "map_id": "none", "name": "G-protein alpha (z):GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10521013", "map_id": "none", "name": "G-protein alpha (z):GTP:Adenylate cyclase", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10570438", "map_id": "none", "name": "Active G alpha (z) binds RGS proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10570436", "map_id": "none", "name": "G alpha (z):GTP:RGS16,17,20", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10528026", "map_id": "none", "name": "Liganded Gz-activating GPCR acts as a GEF for Gz", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10528023", "map_id": "none", "name": "ADRA2A-C:Catecholamine:Heterotrimeric G-protein Gz (active)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10528042", "map_id": "none", "name": "The Ligand:GPCR:Gz complex dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "reaction_10570492", "map_id": "none", "name": "G alpha (z) in G alpha (z):RGS complex is inactivated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10528049", "map_id": "none", "name": "Liganded G12/13-activating GPCR acts as a GEF for G12/13", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10528044", "map_id": "none", "name": "Ligand:GPCR complexes that activate G12/13:Heterotrimeric G-protein G12/13 (inactive).", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q19572", "map_id": "Q19572", "name": "gpa-12", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001674", "map_id": "WBGene00001674", "name": "gpa-12", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10528038", "map_id": "none", "name": "Ligand:GPCR complexes that activate G12/13:Heterotrimeric G-protein G12/13 (active).", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10509505", "map_id": "none", "name": "p115-RhoGEF activation of RHOA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10509486", "map_id": "none", "name": "RHOA:GDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10509502", "map_id": "none", "name": "G13-activated p115-RhoGEF", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "G5EFE1", "map_id": "G5EFE1", "name": "rhgf-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006468", "map_id": "WBGene00006468", "name": "rhgf-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10521106", "map_id": "none", "name": "LARG binds plexin B1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10518605", "map_id": "none", "name": "Homologues of PLXNB1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "O45657", "map_id": "O45657", "name": "plx-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004048", "map_id": "WBGene00004048", "name": "plx-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "U4PRY7", "map_id": "U4PRY7", "name": "plx-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004047", "map_id": "WBGene00004047", "name": "plx-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10521100", "map_id": "none", "name": "G-protein alpha (12/13):LARG", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "H2L0P5", "map_id": "H2L0P5", "name": "prhg-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022391", "map_id": "WBGene00022391", "name": "prhg-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10521104", "map_id": "none", "name": "G-protein alpha (12/13):LARG:Plexin B1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10509507", "map_id": "none", "name": "G alpha (13) activates Rho guanine nucleotide exchange factor 1 (p115-RhoGEF)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10509500", "map_id": "G5EFE1", "name": "rhgf-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10509495", "map_id": "none", "name": "G-protein alpha (13):GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10528051", "map_id": "none", "name": "Inactive G alpha (12/13) reassociates with G beta:gamma", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10521820", "map_id": "none", "name": "G-protein alpha (12/13):GDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10509524", "map_id": "none", "name": "G-protein G12/G13 (inactive)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10521958", "map_id": "none", "name": "GEFs activate RhoA,B,C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10521599", "map_id": "none", "name": "RhoA,B,C:GDP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10516176", "map_id": "none", "name": "GEFs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "G5EF62", "map_id": "G5EF62", "name": "uig-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009337", "map_id": "WBGene00009337", "name": "uig-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9U3P2", "map_id": "Q9U3P2", "name": "syg-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007750", "map_id": "WBGene00007750", "name": "syg-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "X5LV34", "map_id": "X5LV34", "name": "exc-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001366", "map_id": "WBGene00001366", "name": "exc-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "S6EZU2", "map_id": "S6EZU2", "name": "rhgf-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006476", "map_id": "WBGene00006476", "name": "rhgf-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q45FX5", "map_id": "Q45FX5", "name": "vav-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006887", "map_id": "WBGene00006887", "name": "vav-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q21653", "map_id": "Q21653", "name": "osg-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019832", "map_id": "WBGene00019832", "name": "osg-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A0K3AQN0", "map_id": "A0A0K3AQN0", "name": "ARHGEF28", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013682", "map_id": "WBGene00013682", "name": "ARHGEF28", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O01847", "map_id": "O01847", "name": "tiam-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00015704", "map_id": "WBGene00015704", "name": "tiam-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q965J0", "map_id": "Q965J0", "name": "ephx-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019487", "map_id": "WBGene00019487", "name": "ephx-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "H2KYI7", "map_id": "H2KYI7", "name": "cgef-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006496", "map_id": "WBGene00006496", "name": "cgef-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9U364", "map_id": "Q9U364", "name": "ect-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002297", "map_id": "WBGene00002297", "name": "ect-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A0K3AS36", "map_id": "A0A0K3AS36", "name": "itsn-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Y116A8C.36d", "map_id": "Y116A8C.36d", "name": "itsn-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10528040", "map_id": "none", "name": "The Ligand:GPCR:G12/13 complex dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10521096", "map_id": "none", "name": "G-protein alpha (12/13):GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_791498", "map_id": "none", "name": "Ligands of GPCRs that activate G12/13", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10528046", "map_id": "none", "name": "Liganded G12/13-activating GPCRs bind inactive heterotrimeric G-protein G12/13", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10521102", "map_id": "none", "name": "LARG activation by G alpha 12/13", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10516134", "map_id": "none", "name": "Homologues of ARHGEF12", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10521823", "map_id": "none", "name": "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10528246", "map_id": "none", "name": "CD97 binds CD55", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10528242", "map_id": "none", "name": "Homologues of CD55", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "Q22328", "map_id": "Q22328", "name": "lev-9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002976", "map_id": "WBGene00002976", "name": "lev-9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A1N7SYP5", "map_id": "A0A1N7SYP5", "name": "CD46", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009500", "map_id": "WBGene00009500", "name": "CD46", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q18849", "map_id": "Q18849", "name": "CD46", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10524688", "map_id": "G5ECX0", "name": "lat-2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "WBGene00002252", "map_id": "WBGene00002252", "name": "lat-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10528244", "map_id": "none", "name": "CD55:CD97", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "G5ECX0", "map_id": "G5ECX0", "name": "lat-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10524696", "map_id": "none", "name": "EGF-TM7 receptors bind chondroitin sulphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_444761", "map_id": "CHEBI:37397", "name": "CHS", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10524686", "map_id": "G5ECX0", "name": "lat-2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10524694", "map_id": "none", "name": "EGF-7TMs:CHS", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10518464", "map_id": "none", "name": "Metabotropic glutamate receptors bind glutamate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10518460", "map_id": "none", "name": "GRM1-8", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10518462", "map_id": "none", "name": "GRM1-8:L-Glu", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10522001", "map_id": "none", "name": "GABAB heterodimeric receptor binds GABA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10519829", "map_id": "none", "name": "GABBR1:GABBR2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10519831", "map_id": "none", "name": "GABBR1:GABBR2:GABA", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10524672", "map_id": "none", "name": "G-protein coupled bile acid receptor binds lithocholic acid", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_444840", "map_id": "none", "name": "Bile acids", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_5357505", "map_id": "CHEBI:28834", "name": "DCA", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_193451", "map_id": "CHEBI:16359", "name": "cholate", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "CHEBI:16755", "map_id": "CHEBI:16755", "name": "CHEBI:16755", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10524668", "map_id": "none", "name": "Homologues of GPBAR1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10524670", "map_id": "none", "name": "GPBAR1: Bile acids", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10563088", "map_id": "none", "name": "GPR35 binds kynurenic acid", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10563084", "map_id": "H2KZ99", "name": "gnrr-4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_6805204", "map_id": "CHEBI:18344", "name": "Kynurenic acid", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10563086", "map_id": "none", "name": "GPR35:Kynurenic acid", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10520929", "map_id": "none", "name": "DP2 receptor can bind PGD2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_416911", "map_id": "CHEBI:15555", "name": "PGD2", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10519813", "map_id": "none", "name": "Homologues of PTGDR2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10519815", "map_id": "none", "name": "PTGDR2:PGD2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10520931", "map_id": "none", "name": "UDP/CysLT receptor can bind cysteinyl leukotrienes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10519635", "map_id": "H2KZ99", "name": "gnrr-4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_416372", "map_id": "none", "name": "LTC4,LTD4,LTE4", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10519793", "map_id": "none", "name": "GPR17:Cysteinyl leukotrienes", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10520933", "map_id": "none", "name": "BLT receptors can bind LTB4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10519651", "map_id": "none", "name": "LTB4R,LTB4R2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_416436", "map_id": "CHEBI:15647", "name": "LTB4", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10519653", "map_id": "none", "name": "LTB4R,LTB4R2:LTB", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10520935", "map_id": "none", "name": "CYSLT2 binds LTC4,LTD4,LTE4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10519631", "map_id": "none", "name": "Homologues of CYSLTR2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10519633", "map_id": "none", "name": "CYSLTR2:LTC4,LTD4,LTE4", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10573113", "map_id": "none", "name": "CYSLTR1 binds CYSLTR1 antagonists", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10519623", "map_id": "none", "name": "Homologues of CYSLTR1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_9684615", "map_id": "none", "name": "CYSLTR1 antagonists", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10573111", "map_id": "none", "name": "CYSLTR1:CYSLTR1 antagonists", "type": "inhibitor", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10573117", "map_id": "none", "name": "CYSLTR1 binds LTC4,LTD4,LTE4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10519625", "map_id": "none", "name": "CYSLTR1:LTC4,LTD4,LTE4", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10521905", "map_id": "none", "name": "The UDP/CysLT (P2Y17) receptor can bind UTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_417888", "map_id": "CHEBI:17659", "name": "UDP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10519637", "map_id": "none", "name": "GPR17:UDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10521699", "map_id": "none", "name": "P2Y9 receptor can bind to LPA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10519598", "map_id": "H2KZ99", "name": "gnrr-4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10519600", "map_id": "none", "name": "P2RY9:LPA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10521701", "map_id": "none", "name": "P2Y10 receptor can bind to LPA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10519602", "map_id": "H2KZ99", "name": "gnrr-4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10519604", "map_id": "none", "name": "P2RY10:LPA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10521703", "map_id": "none", "name": "P2Y5 receptor can bind to LPA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10519594", "map_id": "H2KZ99", "name": "gnrr-4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10519596", "map_id": "none", "name": "P2RY5:LPA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10521923", "map_id": "none", "name": "ADORA2A,B bind Ade-Rib", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10521919", "map_id": "none", "name": "ADORA2A,B", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_83908", "map_id": "CHEBI:16335", "name": "Ade-Rib", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10521921", "map_id": "none", "name": "ADORA2A,B:Ade-Rib", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10521903", "map_id": "none", "name": "A1 and A3 receptors bind adenosine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10519789", "map_id": "none", "name": "ADORA1,3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10519791", "map_id": "none", "name": "ADORA1,3:Ade-Rib", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10524681", "map_id": "none", "name": "GPR4, GPR65, GPR132 and OGR1 are pH sensing receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10519655", "map_id": "H2KZ99", "name": "gnrr-4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10519659", "map_id": "none", "name": "pH sensing receptors:H+", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10521965", "map_id": "none", "name": "Melanospin is stimulated by light", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10519609", "map_id": "P90745", "name": "npr-3", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_2514888", "compartment_display": "photoreceptor disc membrane", "complex": "false" }, { "id": "species_10519611", "map_id": "none", "name": "Melanospin:photon", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_2514888", "compartment_display": "photoreceptor disc membrane", "complex": "true" }, { "id": "reaction_10520833", "map_id": "none", "name": "CHRM2,4 bind acetylcholine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10519751", "map_id": "Q9U7D5", "name": "gar-3", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10519755", "map_id": "none", "name": "CHRM2,CHRM4:AcCho", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10520829", "map_id": "none", "name": "CHRM1,3,5 bind acetylcholine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10519564", "map_id": "Q9U7D5", "name": "gar-3", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10519570", "map_id": "none", "name": "CHRM1,3,5:AcCho", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10572915", "map_id": "none", "name": "DRD2 binds DA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10572911", "map_id": "Q6RYS9", "name": "dop-3", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_380873", "map_id": "CHEBI:18243", "name": "DA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10572913", "map_id": "none", "name": "DRD2:DA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10520835", "map_id": "none", "name": "D2D3,4 bind to DA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10519725", "map_id": "none", "name": "DRD3,4", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10519727", "map_id": "none", "name": "DRD3,4:DA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10520837", "map_id": "none", "name": "HRH4 binds Hist", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10519710", "map_id": "Q9U7D5", "name": "gar-3", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10519712", "map_id": "none", "name": "HRH4:Hist", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10520846", "map_id": "none", "name": "HRH2 binds hist", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10520842", "map_id": "O45732", "name": "dop-5", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "WBGene00011382", "map_id": "WBGene00011382", "name": "dop-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10520844", "map_id": "none", "name": "HRH2:histamine", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "O45732", "map_id": "O45732", "name": "dop-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10573135", "map_id": "none", "name": "HRH3 binds Hist", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10573131", "map_id": "Q9U7D5", "name": "gar-3", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10573133", "map_id": "none", "name": "HRH3:Hist", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10520848", "map_id": "none", "name": "HTR1 and 5A receptors can bind serotonin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_114523", "map_id": "CHEBI:28790", "name": "5HT", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10519706", "map_id": "none", "name": "HTR1B,D,E,F,HTR5A", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10519708", "map_id": "none", "name": "HTR1B,D,E,F,HTR5A:5HT", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10520865", "map_id": "none", "name": "5-HT4, 6 and 7 receptors can bind serotonin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10520861", "map_id": "none", "name": "HTR4,6,7", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q86ME6", "map_id": "Q86ME6", "name": "dop-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001052", "map_id": "WBGene00001052", "name": "dop-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q22895", "map_id": "Q22895", "name": "ser-7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004780", "map_id": "WBGene00004780", "name": "ser-7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10520863", "map_id": "none", "name": "HTR4,6,7:5HT", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10520850", "map_id": "none", "name": "5-HT2 receptor can bind serotonin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10519586", "map_id": "P91096", "name": "dop-6", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10519592", "map_id": "none", "name": "HTR2A-C:5HT", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10573212", "map_id": "none", "name": "HTR1A binds 5HT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10573208", "map_id": "G5EGH0", "name": "ser-4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10573210", "map_id": "none", "name": "HTR1A:5HT", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10555425", "map_id": "none", "name": "ATG3 transfers LC3 from ATG7 to ATG3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10555420", "map_id": "none", "name": "LC3:CysO572-ATG7:ATG7:ATG3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9N369", "map_id": "Q9N369", "name": "atg-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021922", "map_id": "WBGene00021922", "name": "atg-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EBK4", "map_id": "G5EBK4", "name": "atg-7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010882", "map_id": "WBGene00010882", "name": "atg-7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q09490", "map_id": "Q09490", "name": "lgg-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002980", "map_id": "WBGene00002980", "name": "lgg-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10555422", "map_id": "none", "name": "LC3:CysO263-ATG3:ATG7 dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10555489", "map_id": "none", "name": "Autophagosome maturation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5683628", "compartment_display": "autophagosome membrane" }, { "id": "species_10555350", "map_id": "none", "name": "LC3:PE", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5679192", "compartment_display": "phagophore assembly site membrane", "complex": "true" }, { "id": "species_8959490", "map_id": "CHEBI:16038", "name": "PE", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10555480", "map_id": "none", "name": "LC3:PE", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5683628", "compartment_display": "autophagosome membrane", "complex": "true" }, { "id": "species_10555487", "map_id": "none", "name": "UVRAG complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9TXI7", "map_id": "Q9TXI7", "name": "vps-34", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006932", "map_id": "WBGene00006932", "name": "vps-34", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q22592", "map_id": "Q22592", "name": "phospho-bec-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000247", "map_id": "WBGene00000247", "name": "phospho-bec-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q23669", "map_id": "Q23669", "name": "vps-15", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00014151", "map_id": "WBGene00014151", "name": "vps-15", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A7DT33", "map_id": "A7DT33", "name": "UVRAG", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021319", "map_id": "WBGene00021319", "name": "UVRAG", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10529080", "map_id": "none", "name": "ESCRT-III", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9GYK4", "map_id": "Q9GYK4", "name": "vps-24", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020866", "map_id": "WBGene00020866", "name": "vps-24", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9BL60", "map_id": "Q9BL60", "name": "vps-20", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022027", "map_id": "WBGene00022027", "name": "vps-20", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9U2F6", "map_id": "Q9U2F6", "name": "vps-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012903", "map_id": "WBGene00012903", "name": "vps-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O02208", "map_id": "O02208", "name": "CHMP2B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007216", "map_id": "WBGene00007216", "name": "CHMP2B", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q22718", "map_id": "Q22718", "name": "chmp-7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011976", "map_id": "WBGene00011976", "name": "chmp-7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q18886", "map_id": "Q18886", "name": "vps-32.1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016961", "map_id": "WBGene00016961", "name": "vps-32.1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q21959", "map_id": "Q21959", "name": "CHMP4A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020025", "map_id": "WBGene00020025", "name": "CHMP4A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10554859", "map_id": "none", "name": "Thr-180 of ULK1 is phosphorylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10554667", "map_id": "none", "name": "p-AMPK heterotrimer:AMP:p-S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q22342", "map_id": "Q22342", "name": "epg-7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020334", "map_id": "WBGene00020334", "name": "epg-7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q23023", "map_id": "Q23023", "name": "unc-51", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q95XH2", "map_id": "Q95XH2", "name": "epg-9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022078", "map_id": "WBGene00022078", "name": "epg-9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34379", "map_id": "P34379", "name": "atg-13", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017045", "map_id": "WBGene00017045", "name": "atg-13", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10554856", "map_id": "none", "name": "p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10571498", "map_id": "none", "name": "ATG12 forms a thioester bond with ATG7 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10555409", "map_id": "none", "name": "ATG12:ATG7 dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10555535", "map_id": "none", "name": "ATG12:ATG7:CysO572-ATG7", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10555247", "map_id": "none", "name": "MTORC1 dissociates from ULK complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_74700", "compartment_display": "endosome membrane" }, { "id": "species_10555091", "map_id": "none", "name": "MTORC1 with p-S722,S792-RPTOR:RHEB:GTP:p-S758-ULK1:ATG13:RB1CC1:ATG101", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "species_10510623", "map_id": "none", "name": "mTORC1 with p-S722,S792-RPTOR:Ragulator:Rag:GNP:RHEB:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "species_10554866", "map_id": "none", "name": "p-S758-ULK1:ATG13:RB1CC1:ATG101", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10555567", "map_id": "none", "name": "ATG7:ATG3:LC3 dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10555407", "map_id": "none", "name": "ATG7 dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10555348", "map_id": "none", "name": "CysO263-ATG3:LC3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10554670", "map_id": "none", "name": "AMPK (complex) phosphorylates ULK1 (complex)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10554661", "map_id": "none", "name": "p-AMPK heterotrimer:AMP:ULK1:ATG13:RB1CC1:ATG101", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10555380", "map_id": "none", "name": "ATG16L1 complex transfers LC3 from ATG3 to PE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5681998", "map_id": "CHEBI:16038", "name": "PE", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5679192", "compartment_display": "phagophore assembly site membrane", "complex": "false" }, { "id": "species_10555352", "map_id": "Q9N369", "name": "atg-3", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10555377", "map_id": "none", "name": "ATG16L1 complex:WIPI2:PI(3,5)P2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5679192", "compartment_display": "phagophore assembly site membrane", "complex": "true" }, { "id": "Q19124", "map_id": "Q19124", "name": "atg-16.1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017178", "map_id": "WBGene00017178", "name": "atg-16.1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q09406", "map_id": "Q09406", "name": "atg-16.2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019427", "map_id": "WBGene00019427", "name": "atg-16.2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O16466", "map_id": "O16466", "name": "atg-18", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018294", "map_id": "WBGene00018294", "name": "atg-18", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_5334668", "map_id": "CHEBI:16851", "name": "PI(3,5)P2", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "reaction_10554871", "map_id": "none", "name": "Active MTORC1 phosphorylates ULK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane" }, { "id": "species_10554861", "map_id": "none", "name": "MTORC1:RHEB:GTP:ULK1:ATG13:RB1CC1:ATG101", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "species_10554868", "map_id": "none", "name": "MTORC1:RHEB:GTP:p-S758-ULK1:ATG13:RB1CC1:ATG101", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "reaction_10554873", "map_id": "none", "name": "p-AMPK:AMP binds the ULK complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10554659", "map_id": "none", "name": "ULK1:ATG13:RB1CC1:ATG101", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10555259", "map_id": "none", "name": "ULK1 phosphorylates ATG13 and RB1CC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10555256", "map_id": "none", "name": "p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:p-ATG13:p-RB1CC1:ATG101", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10555452", "map_id": "none", "name": "LC3 is cleaved by ATG4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10555433", "map_id": "none", "name": "LC3 family precursors", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10555340", "map_id": "none", "name": "LC3 family", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10555449", "map_id": "none", "name": "ATG4", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "K8ESC5", "map_id": "K8ESC5", "name": "atg-4.1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013595", "map_id": "WBGene00013595", "name": "atg-4.1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10555454", "map_id": "none", "name": "LC3 binds ATG7 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10555418", "map_id": "none", "name": "LC3:CysO572-ATG7:ATG7", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10555456", "map_id": "none", "name": "LC3 de-lipidation by ATG4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10536642", "map_id": "none", "name": "ULK1 phosphorylates AMBRA1:BECN1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10536602", "map_id": "none", "name": "AMBRA1:DYNLL1,DYNLL2:BECN1 complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9XWQ4", "map_id": "Q9XWQ4", "name": "epg-8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013695", "map_id": "WBGene00013695", "name": "epg-8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10536608", "map_id": "none", "name": "BECN1 complex:p-AMBRA1:DYNLL1,DYNLL2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10536639", "map_id": "none", "name": "p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10554883", "map_id": "none", "name": "Beclin-1 complex phosphorylates PtdIns", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_426639", "map_id": "CHEBI:16749", "name": "PI", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_5676030", "map_id": "CHEBI:26034", "name": "PI3P", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10554880", "map_id": "none", "name": "ATG14:PIK3C3:PIK3R4:p-S15-BECN1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10555396", "map_id": "none", "name": "ULK1 phosphorylates Beclin-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10555394", "map_id": "none", "name": "Beclin-1 complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10554887", "map_id": "none", "name": "Rheb in the MTORC1 complex hydrolyses GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane" }, { "id": "reaction_10555399", "map_id": "none", "name": "MTMR14, MTMR3 dephosphorylate PI3P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10537226", "map_id": "Q22712", "name": "mtm-3", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00003476", "map_id": "WBGene00003476", "name": "mtm-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10555401", "map_id": "none", "name": "ULK complex translocates to the ER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10554891", "map_id": "none", "name": "Active MTORC1 binds the ULK1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10555403", "map_id": "none", "name": "WIPI2 binds ATG12:ATG5:ATG16L", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10555375", "map_id": "none", "name": "WIPI2:PI(3,5)P2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5679192", "compartment_display": "phagophore assembly site membrane", "complex": "true" }, { "id": "species_10555373", "map_id": "none", "name": "ATG16L1 complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10555405", "map_id": "none", "name": "Beclin-1 complex translocates to the ER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10536600", "map_id": "none", "name": "BECN1 complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10555469", "map_id": "none", "name": "The phagophore extends from the PIP3-enriched structure", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10555460", "map_id": "none", "name": "ATG14:PIK3C3:PIK3R4:p-S15-BECN1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5679192", "compartment_display": "phagophore assembly site membrane", "complex": "true" }, { "id": "species_10555465", "map_id": "Q9TXN6", "name": "atg-9", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5679192", "compartment_display": "phagophore assembly site membrane", "complex": "false" }, { "id": "WBGene00020706", "map_id": "WBGene00020706", "name": "atg-9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10555598", "map_id": "none", "name": "ULK1 is dephosphorylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10555537", "map_id": "none", "name": "LC3:ATG7 dimer binds ATG3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10555411", "map_id": "none", "name": "ATG12 binds ATG7 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10555366", "map_id": "Q10931", "name": "lgg-3", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10555093", "map_id": "none", "name": "p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10555284", "map_id": "none", "name": "WIPIs bind PI3P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5693050", "map_id": "CHEBI:17283", "name": "PI3P", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5679192", "compartment_display": "phagophore assembly site membrane", "complex": "false" }, { "id": "species_10555280", "map_id": "none", "name": "WIPI1,WIPI2,(WDR45,WDR45B)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10555282", "map_id": "none", "name": "WIPI1,WIPI2,(WDR45,WDR45B):PI3P", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5679192", "compartment_display": "phagophore assembly site membrane", "complex": "true" }, { "id": "species_1806200", "map_id": "CHEBI:17283", "name": "PI3P", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "reaction_10563248", "map_id": "none", "name": "Active ARF recruits coatomer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_6791047", "compartment_display": "endoplasmic reticulum-Golgi intermediate compartment membrane" }, { "id": "species_10563199", "map_id": "none", "name": "RAB1:GTP:GBF1:USO1:ARF:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_6791047", "compartment_display": "endoplasmic reticulum-Golgi intermediate compartment membrane", "complex": "true" }, { "id": "G5EGG0", "map_id": "G5EGG0", "name": "uso-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010713", "map_id": "WBGene00010713", "name": "uso-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10563246", "map_id": "none", "name": "RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_6791047", "compartment_display": "endoplasmic reticulum-Golgi intermediate compartment membrane", "complex": "true" }, { "id": "reaction_10563616", "map_id": "none", "name": "cis-Golgi t-SNAREs bind YKT6 on tethered vesicle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10563612", "map_id": "none", "name": "cis-Golgi t-SNARES", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "Q95ZW1", "map_id": "Q95ZW1", "name": "gos-28", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017273", "map_id": "WBGene00017273", "name": "gos-28", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P41941", "map_id": "P41941", "name": "memb-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007128", "map_id": "WBGene00007128", "name": "memb-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q20797", "map_id": "Q20797", "name": "syx-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006373", "map_id": "WBGene00006373", "name": "syx-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EEU1", "map_id": "G5EEU1", "name": "nbet-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00043064", "map_id": "WBGene00043064", "name": "nbet-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10563597", "map_id": "none", "name": "RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "Q9N3Y1", "map_id": "Q9N3Y1", "name": "GORASP1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021536", "map_id": "WBGene00021536", "name": "GORASP1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q19989", "map_id": "Q19989", "name": "golg-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018017", "map_id": "WBGene00018017", "name": "golg-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9TXZ9", "map_id": "Q9TXZ9", "name": "ykt-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00015164", "map_id": "WBGene00015164", "name": "ykt-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "E0AHA7", "map_id": "E0AHA7", "name": "unc-70", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006803", "map_id": "WBGene00006803", "name": "unc-70", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EFW3", "map_id": "G5EFW3", "name": "sma-1", "type": "complex_component", 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"inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O44502", "map_id": "O44502", "name": "cogc-8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019820", "map_id": "WBGene00019820", "name": "cogc-8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q21444", "map_id": "Q21444", "name": "cogc-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000585", "map_id": "WBGene00000585", "name": "cogc-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P91151", "map_id": "P91151", "name": "cogc-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016608", "map_id": "WBGene00016608", "name": "cogc-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9U3K1", "map_id": "Q9U3K1", "name": "TMEM115", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008687", "map_id": "WBGene00008687", "name": "TMEM115", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10563614", "map_id": "none", "name": "RAB1:GTP:USO1:coatomer:p24 dimers:cargo:spectrin:ankyrin:COG complex:GOLGA2:GORASP1:TMEM115:cis-SNARE complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "reaction_10563202", "map_id": "none", "name": "GBF1 stimulates ARF nucleotide exchange", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_6791047", "compartment_display": "endoplasmic reticulum-Golgi intermediate compartment membrane" }, { "id": "species_10563193", "map_id": "none", "name": "RAB1:GTP:GBF1:USO1:ARF:GDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_6791047", "compartment_display": "endoplasmic reticulum-Golgi intermediate compartment membrane", "complex": "true" }, { "id": "reaction_10563622", "map_id": "none", "name": "cis-Golgi cis-SNARE binds NSF and SNAPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10563618", "map_id": "none", "name": "cis-Golgi cis SNARE bundle", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "species_10563620", "map_id": "none", "name": "cis-SNARE:3xSNAP:NSF hexamer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "reaction_10563195", "map_id": "none", "name": "GBF1 recruits ARF:GDP to the ERGIC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_6791047", "compartment_display": "endoplasmic reticulum-Golgi intermediate compartment membrane" }, { "id": "species_10563181", "map_id": "none", "name": "RAB1:GTP:GBF1:USO1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_6791047", "compartment_display": "endoplasmic reticulum-Golgi intermediate compartment membrane", "complex": "true" }, { "id": "reaction_10563419", "map_id": "none", "name": "ARFGAPs stimulate ARF GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_6791047", "compartment_display": "endoplasmic reticulum-Golgi intermediate compartment membrane" }, { "id": "species_10563328", "map_id": "none", "name": "RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer:ARFGAP1,2,3:PalmC-YKT6:p24 dimers:cargo:spectrin:ankyrin", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_6791047", "compartment_display": "endoplasmic reticulum-Golgi intermediate compartment membrane", "complex": "true" }, { "id": "species_10563416", "map_id": "none", "name": "RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_432051", "compartment_display": "transport vesicle", "complex": "true" }, { "id": "reaction_10563453", "map_id": "none", "name": "ERGIC-to-Golgi vesicles bind dynein:dynactin ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_432051", "compartment_display": "transport vesicle" }, { "id": "species_10563451", "map_id": "none", "name": "RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_432051", "compartment_display": "transport vesicle", "complex": "true" }, { "id": "reaction_10563183", "map_id": "none", "name": "RAB1:GTP recruits GBF1 to the ERGIC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. 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For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_6791047", "compartment_display": "endoplasmic reticulum-Golgi intermediate compartment membrane" }, { "id": "species_10563177", "map_id": "none", "name": "RAB1:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_6791047", "compartment_display": "endoplasmic reticulum-Golgi intermediate compartment membrane", "complex": "true" }, { "id": "species_10557302", "map_id": "none", "name": "USO1 homodimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10524156", "map_id": "none", "name": "ACSL3,4 ligates coenzyme A (CoA-SH) to palmitate yielding palmitoyl-coenzyme A in the pancreatic beta cell", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane" }, { "id": "species_1132084", "map_id": "CHEBI:33019", "name": "PPi(3-)", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10524153", "map_id": "none", "name": "ACSL3,4", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "true" }, { "id": "reaction_10559061", "map_id": "none", "name": "47S pre-rRNA is nucleolytically processed at A' (01,A1), site A0, and site 02 (site 6) to yield 45S pre-rRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. 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For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10559047", "map_id": "none", "name": "47S pre-rRNA:SSU processome", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9XX15", "map_id": "Q9XX15", "name": "EMG1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012652", "map_id": "WBGene00012652", "name": "EMG1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q22053", "map_id": "Q22053", "name": "fib-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", 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"compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10558892", "map_id": "G5EG59", "name": "crn-5", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10558639", "map_id": "none", "name": "32S pre-rRNA is nucleolytically processed at site 4 (4a) to yield 12S pre-rRNA and 28S rRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10558620", "map_id": "none", "name": "32S pre-rRNA:Rix1:LAS1L:NOL9:SENP3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9U3B6", "map_id": "Q9U3B6", "name": "nol-9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010709", "map_id": "WBGene00010709", "name": "nol-9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q22006", "map_id": "Q22006", "name": "pro-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004185", "map_id": "WBGene00004185", "name": "pro-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XWK5", "map_id": "Q9XWK5", "name": "TEX10", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012977", "map_id": "WBGene00012977", "name": "TEX10", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O44984", "map_id": "O44984", "name": "ulp-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006740", "map_id": "WBGene00006740", "name": "ulp-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q09353", "map_id": "Q09353", "name": "ulp-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006736", "map_id": "WBGene00006736", "name": "ulp-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q23238", "map_id": "Q23238", "name": "ulp-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006737", "map_id": "WBGene00006737", "name": "ulp-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q95Y89", "map_id": "Q95Y89", "name": "lpd-7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003063", "map_id": "WBGene00003063", "name": "lpd-7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P91343", "map_id": "P91343", "name": "wdr-12", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018893", "map_id": "WBGene00018893", "name": "wdr-12", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9U2A9", "map_id": "Q9U2A9", "name": "BOP1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012978", "map_id": "WBGene00012978", "name": "BOP1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9U1T1", "map_id": "Q9U1T1", "name": "LAS1L", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012393", "map_id": "WBGene00012393", "name": "LAS1L", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10558572", "map_id": "none", "name": "28S rRNA:12S pre-rRNA:Rix1:LAS1L:NOL9:SENP3:PeBoW", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10558557", "map_id": "Q9U1T1", "name": "LAS1L", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10558562", "map_id": "Q9U3B6", "name": "nol-9", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10558637", "map_id": "none", "name": "GNL3:EBNA1BP2:DDX21:PES1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q17978", "map_id": "Q17978", "name": "mut-14", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003507", "map_id": "WBGene00003507", "name": "mut-14", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q09958", "map_id": "Q09958", "name": "EBNA1BP2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00015941", "map_id": "WBGene00015941", "name": "EBNA1BP2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q21086", "map_id": "Q21086", "name": "nst-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003821", "map_id": "WBGene00003821", "name": "nst-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10558618", "map_id": "none", "name": "PeBoW complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10570551", "map_id": "none", "name": "p-Y-STAT3:p-STAT5 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10570523", "map_id": "none", "name": "p-Y-STAT3:p-STAT5A,p-STAT5B", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10570549", "map_id": "none", "name": "p-Y-STAT3:p-STAT5A,p-STAT5B", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10570525", "map_id": "none", "name": "p-Y-STAT3 binds p-STAT5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10570521", "map_id": "none", "name": "Homologues of p-Y705-STAT3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10570515", "map_id": "none", "name": "p-Y649-STAT5A, p-STAT5B", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10533095", "map_id": "none", "name": "Phosphorylated p130 (RBL2) binds SCF(Skp2):Cks1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10532102", "map_id": "G5EDT1", "name": "phospho-lin-35", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00003020", "map_id": "WBGene00003020", "name": "lin-35", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10533093", "map_id": "none", "name": "p-T401,S672,1035-RBL2:SCF(Skp2):Cks1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "G5EDT1", "map_id": "G5EDT1", "name": "lin-35", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10533100", "map_id": "none", "name": "Ubiquitination of p130 (RBL2) by SCF (Skp2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10533097", "map_id": "none", "name": "Ub-p-T401,S672,1035-RBL2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10533069", "map_id": "none", "name": "Dephosphorylation of p107 (RBL1) by PP2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10532114", "map_id": "G5EDT1", "name": "phospho-lin-35", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10532106", "map_id": "G5EDT1", "name": "lin-35", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10533066", "map_id": "none", "name": "PP2A", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10533071", "map_id": "none", "name": "Dephosphorylation of p130 (RBL2) by PP2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10532081", "map_id": "G5EDT1", "name": "lin-35", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10531928", "map_id": "none", "name": "STIM1 oligomerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10531921", "map_id": "none", "name": "STIM1:Calcium", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "G5EF60", "map_id": "G5EF60", "name": "stim-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021910", "map_id": "WBGene00021910", "name": "stim-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10531923", "map_id": "none", "name": "STIM1 Dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "species_10531925", "map_id": "none", "name": "ITPR:I(1,4,5)P3 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10542490", "map_id": "none", "name": "STIM1 binds TRPC1 forming STIM1:TRPC1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10542486", "map_id": "Q8I6Y9", "name": "trp-2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10542488", "map_id": "none", "name": "STIM1:TRPC1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10542493", "map_id": "none", "name": "TRPC1 translocates calcium from the extracellular region to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10514689", "map_id": "none", "name": "FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_200665", "map_id": "CHEBI:15641", "name": "5-methyl-THF", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_174404", "map_id": "CHEBI:63907", "name": "5-methyl-THFPG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10513791", "map_id": "Q09509", "name": "FPGS-2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00017777", "map_id": "WBGene00017777", "name": "FPGS-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10513794", "map_id": "none", "name": "FPGS-2 transforms THF to THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_111355", "map_id": "CHEBI:15635", "name": "THF", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_197969", "map_id": "CHEBI:28624", "name": "THFPG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10562914", "map_id": "none", "name": "MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_6803257", "map_id": "CHEBI:63907", "name": "5-formyl-THFPG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_200640", "map_id": "CHEBI:65049", "name": "5,10-methenyl-THFPG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10562911", "map_id": "Q9XWE6", "name": "MTHFS", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00013708", "map_id": "WBGene00013708", "name": "MTHFS", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10514628", "map_id": "none", "name": "5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_200739", "map_id": "CHEBI:60473", "name": "5,10-methylene-THFPG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10514625", "map_id": "none", "name": "MTHFD1 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q21285", "map_id": "Q21285", "name": "dao-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000929", "map_id": "WBGene00000929", "name": "dao-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10562916", "map_id": "none", "name": "MTHFD1L transforms 10-formyl-THF to HCOOH and THF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_113581", "map_id": "CHEBI:456216", "name": "ADP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_5389850", "map_id": "CHEBI:15637", "name": "10-formyl-THF", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_200671", "map_id": "CHEBI:15635", "name": "THF", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_6801451", "map_id": "CHEBI:30751", "name": "HCOOH", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_113593", "map_id": "CHEBI:30616", "name": "ATP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10557703", "map_id": "none", "name": "MTHFD1L dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "reaction_10514694", "map_id": "none", "name": "Mitochondrial FPGS-1 transforms THF to THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_200679", "map_id": "CHEBI:28624", "name": "THFPG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10514691", "map_id": "Q09509", "name": "FPGS-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10514697", "map_id": "none", "name": "MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_111353", "map_id": "CHEBI:28010", "name": "10-formyl-THFPG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10514666", "map_id": "none", "name": "SLC19A1 transports 5-methyl-THF from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_200709", "map_id": "CHEBI:15641", "name": "5-methyl-THF", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10514663", "map_id": "none", "name": "Homologues of SLC19A1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "O45166", "map_id": "O45166", "name": "folt-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018138", "map_id": "WBGene00018138", "name": "folt-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q17766", "map_id": "Q17766", "name": "folt-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007388", "map_id": "WBGene00007388", "name": "folt-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q22931", "map_id": "Q22931", "name": "folt-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00044738", "map_id": "WBGene00044738", "name": "folt-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10513802", "map_id": "none", "name": "DHFR2 reduces FOLA to DHF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_197965", "map_id": "CHEBI:27470", "name": "FOLA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_73604", "map_id": "CHEBI:15633", "name": "DHF", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10513799", "map_id": "Q93341", "name": "dhfr-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00007974", "map_id": "WBGene00007974", "name": "dhfr-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10557706", "map_id": "none", "name": "MTHFD1L dimer ligates HCOOH to THF to form 10-formyl-THF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "reaction_10514699", "map_id": "none", "name": "MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10513804", "map_id": "none", "name": "DHF is reduced to tetrahydrofolate (THF)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10514701", "map_id": "none", "name": "SLC25A32 transports THF from mitochondrial matrix to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane" }, { "id": "species_10514684", "map_id": "Q21084", "name": "slc-25a32", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "WBGene00010459", "map_id": "WBGene00010459", "name": "slc-25a32", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10514669", "map_id": "none", "name": "MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10514703", "map_id": "none", "name": "SLC46A1 transports FOLA from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_200716", "map_id": "CHEBI:27470", "name": "FOLA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10563441", "map_id": "none", "name": "ALDH1L2 dehydrogenates 10-formyl-THFPG to THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_113563", "map_id": "CHEBI:18009", "name": "NADP+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_6808499", "map_id": "CHEBI:28010", "name": "10-formyl-THFPG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_113600", "map_id": "CHEBI:16474", "name": "NADPH", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_29376", "map_id": "CHEBI:16526", "name": "CO2", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10563438", "map_id": "none", "name": "ADH1L2 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "G5ECV9", "map_id": "G5ECV9", "name": "phospho-alh-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000109", "map_id": "WBGene00000109", "name": "phospho-alh-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10514705", "map_id": "none", "name": "SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10503873", "map_id": "none", "name": "SHMT1 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P50432", "map_id": "P50432", "name": "mel-32", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003214", "map_id": "WBGene00003214", "name": "mel-32", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10514707", "map_id": "none", "name": "5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10573332", "map_id": "none", "name": "DHFR dimer reduces FOLA to DHF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10573329", "map_id": "none", "name": "DHFR dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q93341", "map_id": "Q93341", "name": "dhfr-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10514679", "map_id": "none", "name": "MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10514676", "map_id": "none", "name": "MTHFR dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q17693", "map_id": "Q17693", "name": "mthf-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00015512", "map_id": "WBGene00015512", "name": "mthf-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10563449", "map_id": "none", "name": "ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10563446", "map_id": "none", "name": "ALDH1L1 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10514653", "map_id": "none", "name": "Cytosolic folate export across the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10514655", "map_id": "none", "name": "5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10507440", "map_id": "none", "name": "Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10507428", "map_id": "none", "name": "Pol II initiation complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "G5EG49", "map_id": "G5EG49", "name": "gtf-2e1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013998", "map_id": "WBGene00013998", "name": "gtf-2e1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EG47", "map_id": "G5EG47", "name": "gtf-2e2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010054", "map_id": "WBGene00010054", "name": "gtf-2e2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O44625", "map_id": "O44625", "name": "pqn-51", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004136", "map_id": "WBGene00004136", "name": "pqn-51", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9NEX2", "map_id": "Q9NEX2", "name": "gtf-2A2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013736", "map_id": "WBGene00013736", "name": "gtf-2A2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q95ZS0", "map_id": "Q95ZS0", "name": "taf-10", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006392", "map_id": "WBGene00006392", "name": "taf-10", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9GZI6", "map_id": "Q9GZI6", "name": "taf-6.1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006387", "map_id": "WBGene00006387", "name": "taf-6.1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EF68", "map_id": "G5EF68", "name": "taf-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006386", "map_id": "WBGene00006386", "name": "taf-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O45784", "map_id": "O45784", "name": "taf-9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006391", "map_id": "WBGene00006391", "name": "taf-9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P32085", "map_id": "P32085", "name": "tbp-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006542", "map_id": "WBGene00006542", "name": "tbp-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O61707", "map_id": "O61707", "name": "taf-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006385", "map_id": "WBGene00006385", "name": "taf-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9NEW8", "map_id": "Q9NEW8", "name": "taf-7.2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006389", "map_id": "WBGene00006389", "name": "taf-7.2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9TYN3", "map_id": "Q9TYN3", "name": "taf-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006383", "map_id": "WBGene00006383", "name": "taf-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q18265", "map_id": "Q18265", "name": "fust-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016173", "map_id": "WBGene00016173", "name": "fust-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q17957", "map_id": "Q17957", "name": "taf-13", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006397", "map_id": "WBGene00006397", "name": "taf-13", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "E9P861", "map_id": "E9P861", "name": "taf-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006384", "map_id": "WBGene00006384", "name": "taf-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q20361", "map_id": "Q20361", "name": "taf-11.3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006395", "map_id": "WBGene00006395", "name": "taf-11.3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EGM3", "map_id": "G5EGM3", "name": "taf-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006382", "map_id": "WBGene00006382", "name": "taf-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O16991", "map_id": "O16991", "name": "ttb-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006648", "map_id": "WBGene00006648", "name": "ttb-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10507436", "map_id": "none", "name": "Pol II Initiation complex with phosphodiester-PPi intermediate", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10507430", "map_id": "none", "name": "NTP Binds Active Site of RNA Polymerase II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10507424", "map_id": "none", "name": "pol II open pre-initiation complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10507438", "map_id": "none", "name": "Newly Formed Phosphodiester Bond Stabilized and PPi Released", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10506530", "map_id": "none", "name": "pol II transcription complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10568438", "map_id": "none", "name": "RUNX1 binds ELF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10566201", "map_id": "none", "name": "RUNX1:CBFB", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q95ZL9", "map_id": "Q95ZL9", "name": "bro-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000272", "map_id": "WBGene00000272", "name": "bro-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EFQ5", "map_id": "G5EFQ5", "name": "rnt-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004393", "map_id": "WBGene00004393", "name": "rnt-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10568434", "map_id": "H2KYY1", "name": "elf-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00016029", "map_id": "WBGene00016029", "name": "elf-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10568436", "map_id": "none", "name": "RUNX1:CBFB:ELF1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "H2KYY1", "map_id": "H2KYY1", "name": "elf-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10558118", "map_id": "none", "name": "MEMO1 binds RHOA:GTP:DIAPH1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10558114", "map_id": "none", "name": "p-ERBB2 heterodimers:MEMO1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q22915", "map_id": "Q22915", "name": "memo-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016500", "map_id": "WBGene00016500", "name": "memo-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10554688", "map_id": "none", "name": "RHOA:GTP:DIAPH1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q19479", "map_id": "Q19479", "name": "inft-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008848", "map_id": "WBGene00008848", "name": "inft-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7JP75", "map_id": "Q7JP75", "name": "cyk-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000872", "map_id": "WBGene00000872", "name": "cyk-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10558116", "map_id": "none", "name": "p-ERBB2 heterodimers:MEMO1:RHOA:GTP:DIAPH1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10520920", "map_id": "none", "name": "Association of CCT/TriC with sphingosine kinase 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10520872", "map_id": "Q18425", "name": "sphk-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00007918", "map_id": "WBGene00007918", "name": "sphk-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10520916", "map_id": "none", "name": "CCT/TRiC:ADP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P46550", "map_id": "P46550", "name": "cct-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000381", "map_id": "WBGene00000381", "name": "cct-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9TZS5", "map_id": "Q9TZS5", "name": "cct-7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020391", "map_id": "WBGene00020391", "name": "cct-7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P47207", "map_id": "P47207", "name": "cct-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000378", "map_id": "WBGene00000378", "name": "cct-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9N4J8", "map_id": "Q9N4J8", "name": "cct-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018782", "map_id": "WBGene00018782", "name": "cct-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P47208", "map_id": "P47208", "name": "cct-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000379", "map_id": "WBGene00000379", "name": "cct-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9N358", "map_id": "Q9N358", "name": "cct-8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021934", "map_id": "WBGene00021934", "name": "cct-8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P47209", "map_id": "P47209", "name": "cct-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000380", "map_id": "WBGene00000380", "name": "cct-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P41988", "map_id": "P41988", "name": "cct-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000377", "map_id": "WBGene00000377", "name": "cct-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10520918", "map_id": "none", "name": "CCT/TRiC:ADP:Sphingosine kinase 1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q18425", "map_id": "Q18425", "name": "sphk-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10564273", "map_id": "none", "name": "PDCL promotes formation of G-beta:G-gamma heterodimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10509151", "map_id": "none", "name": "G-protein gamma subunit", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10564267", "map_id": "none", "name": "p-S18,S19,S20,S25-PDCL:G-protein beta 1-4 subunit", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9U1X7", "map_id": "Q9U1X7", "name": "mau-8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003142", "map_id": "WBGene00003142", "name": "mau-8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10564271", "map_id": "none", "name": "p-S18,S19,S20,S25-PDCL:G-protein beta 1-4:gamma complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10565025", "map_id": "none", "name": "G-protein alpha releases G-protein heterotrimer from PDCL ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10565023", "map_id": "none", "name": "G-protein heterotrimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10564228", "map_id": "Q9U1X7", "name": "phospho-mau-8", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10564213", "map_id": "none", "name": "TRiC/CCT binds unfolded G-protein beta subunit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10509163", "map_id": "none", "name": "G-protein beta subunit", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10564211", "map_id": "none", "name": "Unfolded G-protein beta subunit:CCT/TRiC:ADP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10565013", "map_id": "none", "name": "RGS proteins bind GNB5 and CCT/TRiC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10565009", "map_id": "none", "name": "RGS7,RGS9,(RGS6,RGS11)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10564993", "map_id": "none", "name": "GNB5:CCT/TRiC:ADP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q20636", "map_id": "Q20636", "name": "gpb-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001680", "map_id": "WBGene00001680", "name": "gpb-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10565011", "map_id": "none", "name": "RGS7,RGS9,(RGS6,RGS11):GNB5:CCT/TRiC:ADP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10564265", "map_id": "none", "name": "CK2 phosphorylates PDCL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10564263", "map_id": "Q9U1X7", "name": "mau-8", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10565017", "map_id": "none", "name": "PDCL promotes G-protein beta 5 folding", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10565015", "map_id": "none", "name": "p-S18,S19,S20,S25-PDCL:Partially folded GNB5:CCT/TRiC:ADP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10564232", "map_id": "none", "name": "PDCL binds G-protein beta and TRiC/CCT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10564230", "map_id": "none", "name": "p-S18,S19,S20,S25-PDCL:Partially folded G-protein beta subunit:CCT/TRiC:ADP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10564219", "map_id": "none", "name": "ATP hydrolysis promotes folding of G-protein beta by TRiC/CCT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10564217", "map_id": "none", "name": "Unfolded G-protein beta subunit:CCT/TRiC:ATP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10564234", "map_id": "none", "name": "ATP binds G-protein beta associated TRiC/CCT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10565021", "map_id": "none", "name": "Release of GNB5:RGS dimers from CCT/TRiC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10565019", "map_id": "none", "name": "GNB5:(RGS7,RGS9,(RGS6,RGS11))", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10564991", "map_id": "none", "name": "PDCL releases folded G-beta from TRiC/CCT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10564989", "map_id": "none", "name": "p-S18,S19,S20,S25-PDCL:Partially folded G-protein beta 1-4:CCT/TRiC:ADP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10524242", "map_id": "none", "name": "SLC31A1 transports Cu2+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_437295", "map_id": "CHEBI:29036", "name": "Cu2+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_209799", "map_id": "CHEBI:29036", "name": "Cu2+", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10524239", "map_id": "Q6BEW1", "name": "SLC31A1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "WBGene00017852", "map_id": "WBGene00017852", "name": "SLC31A1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10524450", "map_id": "none", "name": "SLC41A1,2 transport Mg2+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_29926", "map_id": "CHEBI:18420", "name": "Mg2+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10524447", "map_id": "none", "name": "SLC41A1,2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "O02340", "map_id": "O02340", "name": "SLC41A2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022682", "map_id": "WBGene00022682", "name": "SLC41A2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O44196", "map_id": "O44196", "name": "SLC41A2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O45182", "map_id": "O45182", "name": "SLC41A2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10524215", "map_id": "none", "name": "ZnT5 transports zinc into secretory granules in pancreatic beta cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_1462052", "compartment_display": "secretory granule lumen" }, { "id": "species_29426", "map_id": "CHEBI:29105", "name": "Zn2+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10524212", "map_id": "Q8WQB6", "name": "slc-30a5", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_216813", "compartment_display": "secretory granule membrane", "complex": "false" }, { "id": "WBGene00013668", "map_id": "WBGene00013668", "name": "slc-30a5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10524231", "map_id": "none", "name": "ZnT6 transports zinc into the golgi apparatus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_216667", "map_id": "CHEBI:29105", "name": "Zn2+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10524228", "map_id": "Q45EL5", "name": "toc-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "WBGene00006590", "map_id": "WBGene00006590", "name": "toc-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10524207", "map_id": "none", "name": "ZnT1 mediates the efflux of zinc from the cell", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_158417", "map_id": "CHEBI:29105", "name": "Zn2+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10524204", "map_id": "Q95QW4", "name": "cdf-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "WBGene00000393", "map_id": "WBGene00000393", "name": "cdf-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10524223", "map_id": "none", "name": "SLC30A8 transports Zn2+ from cytosol to secretory granule", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10524220", "map_id": "Q22541", "name": "cdf-2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_216813", "compartment_display": "secretory granule membrane", "complex": "false" }, { "id": "WBGene00011821", "map_id": "WBGene00011821", "name": "cdf-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10524385", "map_id": "none", "name": "ZIP7 mediates zinc efflux from the endoplasmic reticulum", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_442320", "map_id": "CHEBI:29105", "name": "Zn2+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10524382", "map_id": "Q9XTQ7", "name": "zipt-7.2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "WBGene00006494", "map_id": "WBGene00006494", "name": "zipt-7.2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10524344", "map_id": "none", "name": "ZIP6 and ZIP14 mediate zinc influx into cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10524341", "map_id": "none", "name": "ZIP6/ZIP14", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "U4PS08", "map_id": "U4PS08", "name": "zipt-15", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021936", "map_id": "WBGene00021936", "name": "zipt-15", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q22395", "map_id": "Q22395", "name": "zipt-16", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006486", "map_id": "WBGene00006486", "name": "zipt-16", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10524377", "map_id": "none", "name": "ZIP8 mediates zinc influx into cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10524374", "map_id": "none", "name": "SLC39A8-like proteins", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10524426", "map_id": "none", "name": "SLC39A1-4 transports Zn2+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10524423", "map_id": "none", "name": "SLC39A1-4", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q09957", "map_id": "Q09957", "name": "zipt-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00015940", "map_id": "WBGene00015940", "name": "zipt-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P91348", "map_id": "P91348", "name": "zipt-2.4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018897", "map_id": "WBGene00018897", "name": "zipt-2.4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q19913", "map_id": "Q19913", "name": "zipt-2.2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017936", "map_id": "WBGene00017936", "name": "zipt-2.2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q6BEU0", "map_id": "Q6BEU0", "name": "zipt-2.1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00014669", "map_id": "WBGene00014669", "name": "zipt-2.1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O62192", "map_id": "O62192", "name": "zipt-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009286", "map_id": "WBGene00009286", "name": "zipt-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XWH3", "map_id": "Q9XWH3", "name": "zipt-2.3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013207", "map_id": "WBGene00013207", "name": "zipt-2.3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10524199", "map_id": "none", "name": "SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_435347", "map_id": "CHEBI:29033", "name": "Fe2+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_71067", "map_id": "CHEBI:29033", "name": "Fe2+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10524196", "map_id": "Q21434", "name": "smf-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10570186", "map_id": "none", "name": "SLC30A10 transports Mn2+ from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29418", "map_id": "CHEBI:29035", "name": "Mn2+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10570183", "map_id": "Q95QW4", "name": "cdf-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10524366", "map_id": "none", "name": "SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10524363", "map_id": "none", "name": "SLC40A1:HEPH:6Cu2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "O44607", "map_id": "O44607", "name": "fpn-1.2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019977", "map_id": "WBGene00019977", "name": "fpn-1.2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8IA95", "map_id": "Q8IA95", "name": "fpn-1.1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021354", "map_id": "WBGene00021354", "name": "fpn-1.1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:28694", "map_id": "CHEBI:28694", "name": "CHEBI:28694", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q19687", "map_id": "Q19687", "name": "CP", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009008", "map_id": "WBGene00009008", "name": "CP", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10528430", "map_id": "none", "name": "SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10528427", "map_id": "none", "name": "SLC40A1:CP:6Cu2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10507115", "map_id": "none", "name": "Formation of AT-AC C complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10507111", "map_id": "none", "name": "ATAC B Complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q17348", "map_id": "Q17348", "name": "snr-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004914", "map_id": "WBGene00004914", "name": "snr-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9N4G9", "map_id": "Q9N4G9", "name": "snr-7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": 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For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10505213", "map_id": "none", "name": "CF I", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10505197", "map_id": "Q93233", "name": "pabp-2", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10505225", "map_id": "none", "name": "CF II", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10505192", "map_id": "none", "name": "Homologues of PAPOLA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10505175", "map_id": "none", "name": "CstF", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10505156", "map_id": "none", "name": "CPSF", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10505227", "map_id": "none", "name": "Cleavage and Polyadenylation Complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10505260", "map_id": "none", "name": "Formation of an intermediate Spliceosomal C (Bact) complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10505247", "map_id": "G5EBT5", "name": "mog-3", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10505242", "map_id": "Q21924", "name": "gkow-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10505237", "map_id": "O45244", "name": "mog-4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10505232", "map_id": "Q9BL61", "name": "EIF4A3", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10505037", "map_id": "O44787", "name": "usp-39", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10504940", "map_id": "none", "name": "U4 snRNP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10504907", "map_id": "Q9XUY1", "name": "wbp-4", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10505032", "map_id": "Q21739", "name": "snrp-27", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10504979", "map_id": "none", "name": "LSM2-8 complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10505027", "map_id": "O01524", "name": "sart-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10504608", "map_id": "none", "name": "U1 snRNP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10509836", "map_id": "none", "name": "Formation of Exon Junction Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10505291", "map_id": "none", "name": "Magoh-Y14 complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10509834", "map_id": "none", "name": "Spliceosomal active C complex with lariat containing, 5'-end cleaved pre-mRNP:CBC complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q09385", "map_id": "Q09385", "name": "syf-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019402", "map_id": "WBGene00019402", "name": "syf-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10505299", "map_id": "none", "name": "pre-EJC:Spliceosomal C:pre-mRNP:CBC", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10509984", "map_id": "none", "name": "NXF1:NXT1 (TAP:p15) binds capped mRNA:CBC:EJC:TREX (minus DDX39B)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10505377", "map_id": "none", "name": "polyadenylated, capped mRNA:CBC:EJC:TREX:SRSF proteins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "P91867", "map_id": "P91867", "name": "thoc-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009341", "map_id": "WBGene00009341", "name": "thoc-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "C2BR94", "map_id": "C2BR94", "name": "thoc-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021311", "map_id": "WBGene00021311", "name": "thoc-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9N5E3", "map_id": "Q9N5E3", "name": "thoc-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020172", "map_id": "WBGene00020172", "name": "thoc-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q18033", "map_id": "Q18033", "name": "thoc-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00015813", "map_id": "WBGene00015813", "name": "thoc-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9U3S3", "map_id": "Q9U3S3", "name": "thoc-7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007195", "map_id": "WBGene00007195", "name": "thoc-7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9N3G0", "map_id": "Q9N3G0", "name": "SARNP", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021813", "map_id": "WBGene00021813", "name": "SARNP", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q18212", "map_id": "Q18212", "name": "hel-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001840", "map_id": "WBGene00001840", "name": "hel-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q21278", "map_id": "Q21278", "name": "hSLU7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010629", "map_id": "WBGene00010629", "name": "hSLU7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10507168", "map_id": "none", "name": "NXF1,2:NXT1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9U757", "map_id": "Q9U757", "name": "nxt-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003836", "map_id": "WBGene00003836", "name": "nxt-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XVS8", "map_id": "Q9XVS8", "name": "nxf-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003835", "map_id": "WBGene00003835", "name": "nxf-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XVS7", "map_id": "Q9XVS7", "name": "nxf-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003834", "map_id": "WBGene00003834", "name": "nxf-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10509981", "map_id": "none", "name": "NXF1,2:NXT1::polyadenylated, capped mRNA:CBC:EJC:TREX:SRSF proteins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10509975", "map_id": "none", "name": "DDX39B:ADP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10505380", "map_id": "none", "name": "mRNA polyadenylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10505370", "map_id": "none", "name": "3' end cleaved, ligated exon containing complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10505375", "map_id": "none", "name": "Cleavage of mRNA at the 3'-end", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10505368", "map_id": "none", "name": "Spliced mRNA:CBC:EJC:TREX", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10505372", "map_id": "none", "name": "mRNA 3'-end cleavage factor", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10553705", "map_id": "none", "name": "Retrograde IFT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_18730", "compartment_display": "cilium" }, { "id": "species_10553703", "map_id": "none", "name": "retrograde IFT trains", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5263228", "compartment_display": "ciliary tip", "complex": "true" }, { "id": "Q19542", "map_id": "Q19542", "name": "che-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000485", "map_id": "WBGene00000485", "name": "che-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q18263", "map_id": "Q18263", "name": "wdr-60", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016165", "map_id": "WBGene00016165", "name": "wdr-60", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q19119", "map_id": "Q19119", "name": "xbx-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006960", "map_id": "WBGene00006960", "name": "xbx-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q22752", "map_id": "Q22752", "name": "dyrb-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012004", "map_id": "WBGene00012004", "name": "dyrb-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q0G838", "map_id": "Q0G838", "name": "dyf-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001122", "map_id": "WBGene00001122", "name": "dyf-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EDF6", "map_id": "G5EDF6", "name": "osm-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003886", "map_id": "WBGene00003886", "name": "osm-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q93833", "map_id": "Q93833", "name": "che-13", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000492", "map_id": "WBGene00000492", "name": "che-13", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A2C9C2L6", "map_id": "A0A2C9C2L6", "name": "ift-74", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016005", "map_id": "WBGene00016005", "name": "ift-74", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EGF0", "map_id": "G5EGF0", "name": "che-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000484", "map_id": "WBGene00000484", "name": "che-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A8DYR7", "map_id": "A8DYR7", "name": "ift-81", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017973", "map_id": "WBGene00017973", "name": "ift-81", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XUC2", "map_id": "Q9XUC2", "name": "ifta-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012132", "map_id": "WBGene00012132", "name": "ifta-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q17595", "map_id": "Q17595", "name": "dyf-11", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001127", "map_id": "WBGene00001127", "name": "dyf-11", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q6I6D4", "map_id": "Q6I6D4", "name": "dyf-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001119", "map_id": "WBGene00001119", "name": "dyf-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q95QT8", "map_id": "Q95QT8", "name": "dyf-13", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001129", "map_id": "WBGene00001129", "name": "dyf-13", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8I7G4", "map_id": "Q8I7G4", "name": "dyf-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001117", "map_id": "WBGene00001117", "name": "dyf-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q22830", "map_id": "Q22830", "name": "osm-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003883", "map_id": "WBGene00003883", "name": "osm-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8TA52", "map_id": "Q8TA52", "name": "ift-20", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022465", "map_id": "WBGene00022465", "name": "ift-20", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q965T6", "map_id": "Q965T6", "name": "klp-20", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002230", "map_id": "WBGene00002230", "name": "klp-20", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EEE6", "map_id": "G5EEE6", "name": "kap-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002182", "map_id": "WBGene00002182", "name": "kap-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q19633", "map_id": "Q19633", "name": "klp-11", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002222", "map_id": "WBGene00002222", "name": "klp-11", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10553699", "map_id": "none", "name": "retrograde IFT trains", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_18730", "compartment_display": "cilium", "complex": "true" }, { "id": "reaction_10552842", "map_id": "none", "name": "TRIP11:IFT20 dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10552840", "map_id": "none", "name": "IFT20:TRIP11", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "D0Z5P0", "map_id": "D0Z5P0", "name": "sql-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013730", "map_id": "WBGene00013730", "name": "sql-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10552838", "map_id": "D0Z5P0", "name": "sql-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "species_10552833", "map_id": "Q8TA52", "name": "ift-20", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "reaction_10553695", "map_id": "none", "name": "Anterograde IFT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_18730", "compartment_display": "cilium" }, { "id": "species_10553659", "map_id": "none", "name": "anterograde IFT trains", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_18730", "compartment_display": "cilium", "complex": "true" }, { "id": "species_10553693", "map_id": "none", "name": "anterograde IFT trains", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5263228", "compartment_display": "ciliary tip", "complex": "true" }, { "id": "reaction_10565360", "map_id": "none", "name": "Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10565305", "map_id": "none", "name": "Ub-Cys632-UBA1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10565307", "map_id": "none", "name": "Ub-Cys632-UBA1:ubiquitin adenylate", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10565363", "map_id": "none", "name": "Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10565228", "map_id": "none", "name": "Ub-Cys632-UBA1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10565258", "map_id": "none", "name": "Ub-Cys632-UBA1:ubiquitin adenylate", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10565303", "map_id": "none", "name": "UBA1 conjugates ubiquitin to cytosolic E2 enzymes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10565226", "map_id": "none", "name": "E2 ubiquitin conjugating enzyme (UBA1 substrate)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9U1Q1", "map_id": "Q9U1Q1", "name": "ubc-14", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006709", "map_id": "WBGene00006709", "name": "ubc-14", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q95XN7", "map_id": "Q95XN7", "name": "ubc-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006702", "map_id": "WBGene00006702", "name": "ubc-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9TZ69", "map_id": "Q9TZ69", "name": "ubc-20", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006715", "map_id": "WBGene00006715", "name": "ubc-20", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9N2W9", "map_id": "Q9N2W9", "name": "ubc-8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006705", "map_id": "WBGene00006705", "name": "ubc-8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34477", "map_id": "P34477", "name": "ubc-7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006704", "map_id": "WBGene00006704", "name": "ubc-7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q93571", "map_id": "Q93571", "name": "ubc-25", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006720", "map_id": "WBGene00006720", "name": "ubc-25", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10565260", "map_id": "none", "name": "UBA1:ubiquitin adenylate", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10565301", "map_id": "none", "name": "Ub:E2 (UBA1 substrate)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10565366", "map_id": "none", "name": "UBA1 conjugates ubiquitin to UBA1 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10565369", "map_id": "none", "name": "UBA1 adenylates ubiquitin in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10531318", "map_id": "Q27481", "name": "uba-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10565432", "map_id": "none", "name": "UCHL3,USP7,USP9X cleaves UBA52 yielding ubiquitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10565425", "map_id": "P37165", "name": "ubl-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10502349", "map_id": "P37165", "name": "ubl-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10505892", "map_id": "P37165", "name": "ubl-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10565429", "map_id": "none", "name": "UCHL3,USP7,USP9X", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q7JKC3", "map_id": "Q7JKC3", "name": "math-33", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010406", "map_id": "WBGene00010406", "name": "math-33", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9UAV3", "map_id": "Q9UAV3", "name": "ubh-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006721", "map_id": "WBGene00006721", "name": "ubh-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10565224", "map_id": "none", "name": "UBA1 adenylates ubiquitin in the nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10565179", "map_id": "Q27481", "name": "uba-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10565222", "map_id": "none", "name": "UBA1:ubiquitin adenylate", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10565371", "map_id": "none", "name": "UBA1 conjugates ubiquitin to UBA1 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_164121", "map_id": "CHEBI:16027", "name": "AMP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10565358", "map_id": "none", "name": "UBA1 conjugates ubiquitin to nuclear E2 enzymes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10565326", "map_id": "none", "name": "E2 ubiquitin conjugating enzyme (UBA1 substrate)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q20872", "map_id": "Q20872", "name": "uev-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006731", "map_id": "WBGene00006731", "name": "uev-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XWF6", "map_id": "Q9XWF6", "name": "ubc-16", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006711", "map_id": "WBGene00006711", "name": "ubc-16", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P52478", "map_id": "P52478", "name": "ubc-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006701", "map_id": "WBGene00006701", "name": "ubc-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10565356", "map_id": "none", "name": "Ub:E2 (UBA1 substrate)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10532323", "map_id": "none", "name": "RHAG transports CO2 from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1237009", "map_id": "CHEBI:16526", "name": "CO2", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10524631", "map_id": "none", "name": "Homologues of RHAG", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q17463", "map_id": "Q17463", "name": "rhr-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004359", "map_id": "WBGene00004359", "name": "rhr-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q22947", "map_id": "Q22947", "name": "rhr-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004358", "map_id": "WBGene00004358", "name": "rhr-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10534719", "map_id": "none", "name": "CA1:Zn2+,CA2:Zn2+ dehydrate HCO3- to CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10534714", "map_id": "none", "name": "CA1:Zn2+,CA2:Zn2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "O02637", "map_id": "O02637", "name": "cah-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000284", "map_id": "WBGene00000284", "name": "cah-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q10462", "map_id": "Q10462", "name": "cah-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000283", "map_id": "WBGene00000283", "name": "cah-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q21614", "map_id": "Q21614", "name": "cah-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000282", "map_id": "WBGene00000282", "name": "cah-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q27504", "map_id": "Q27504", "name": "cah-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000281", "map_id": "WBGene00000281", "name": "cah-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10568241", "map_id": "none", "name": "AHR:2xHSP90:AIP:PTGES3 binds TCDD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_8936852", "map_id": "CHEBI:28119", "name": "TCDD", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10568237", "map_id": "none", "name": "AHR:2xHSP90AB1:AIP:PTGES3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q18688", "map_id": "Q18688", "name": "daf-21", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000915", "map_id": "WBGene00000915", "name": "daf-21", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O44712", "map_id": "O44712", "name": "ahr-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000096", "map_id": "WBGene00000096", "name": "ahr-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q18888", "map_id": "Q18888", "name": "aipr-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016966", "map_id": "WBGene00016966", "name": "aipr-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q23280", "map_id": "Q23280", "name": "daf-41", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022599", "map_id": "WBGene00022599", "name": "daf-41", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10568239", "map_id": "none", "name": "AHR:TCDD:2xHSP90AB1:AIP:PTGES3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10568289", "map_id": "none", "name": "AHR:TCDD:2xHSP90AB1:AIP:PTGES3 dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10568281", "map_id": "none", "name": "AHR:TCDD:2xHSP90AB1:AIP:PTGES3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10556878", "map_id": "none", "name": "AHR:TCDD", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10568287", "map_id": "none", "name": "2xHSP90AB1:AIP:PTGES3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10568243", "map_id": "none", "name": "AHRR binds ARNT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10532219", "map_id": "O02219", "name": "aha-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00000095", "map_id": "WBGene00000095", "name": "aha-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10556884", "map_id": "O44712", "name": "ahr-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10556886", "map_id": "none", "name": "AHRR:ARNT", "type": "inhibitor", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "O02219", "map_id": "O02219", "name": "aha-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10568283", "map_id": "none", "name": "AHR:TCDD:2xHSP90AB1:AIP:PTGES3 translocates from cytosol to nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10568285", "map_id": "none", "name": "AHR:TCDD binds ARNT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10556882", "map_id": "none", "name": "AHR:TCDD:ARNT", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10569050", "map_id": "none", "name": "RUNX3 binds TEADs and YAP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10566205", "map_id": "G5EFQ5", "name": "rnt-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10542185", "map_id": "none", "name": "TEAD1:YAP1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q19849", "map_id": "Q19849", "name": "egl-44", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001208", "map_id": "WBGene00001208", "name": "egl-44", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10569048", "map_id": "none", "name": "RUNX3:YAP1:TEAD1,TEAD4,(TEAD2,TEAD3)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10569036", "map_id": "none", "name": "RUNX3 binds CTNNB1:TCF7L2,(LEF1,TCF7L1,TCF7)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10547172", "map_id": "none", "name": "TCF/LEF:CTNNB1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10569034", "map_id": "none", "name": "RUNX3:CTNNB1:TCF7L2,(LEF1,TCF7L1,TCF7)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10527860", "map_id": "none", "name": "SLC35A3 exchanges UDP-GlcNAc for UMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_735698", "map_id": "CHEBI:16695", "name": "uridine 5'-monophosphate", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_914003", "map_id": "CHEBI:16264", "name": "UDP-GlcNAc", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10527857", "map_id": "O16658", "name": "nstp-4", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "WBGene00015404", "map_id": "WBGene00015404", "name": "nstp-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10527876", "map_id": "none", "name": "SLC35B4 mediates the transport of UDP-N-acetylglucosamine into the Golgi lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10527873", "map_id": "O44166", "name": "nstp-2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "WBGene00017480", "map_id": "WBGene00017480", "name": "nstp-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10527879", "map_id": "none", "name": "SLC35B4 mediates the transport of UDP-xylose into the Golgi lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_742353", "map_id": "CHEBI:16082", "name": "UDP-Xyl", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_742361", "map_id": "CHEBI:16082", "name": "UDP-Xyl", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "reaction_10527832", "map_id": "none", "name": "SLC35A1 exchanges CMP-Neu5Ac for CMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_727810", "map_id": "CHEBI:17361", "name": "CMP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_4085435", "map_id": "CHEBI:16556", "name": "CMP-Neu5Ac", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_727815", "map_id": "CHEBI:16556", "name": "CMP-Neu5Ac", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10527829", "map_id": "none", "name": "Homologues of SLC35A1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "Q93890", "map_id": "Q93890", "name": "srf-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00005153", "map_id": "WBGene00005153", "name": "srf-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O01879", "map_id": "O01879", "name": "nstp-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022577", "map_id": "WBGene00022577", "name": "nstp-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O02345", "map_id": "O02345", "name": "nstp-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00014139", "map_id": "WBGene00014139", "name": "nstp-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q02334", "map_id": "Q02334", "name": "ugtp-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022721", "map_id": "WBGene00022721", "name": "ugtp-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10527868", "map_id": "none", "name": "SLC35C1 transport UDP-Fuc from cytosol to Golgi lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_742368", "map_id": "CHEBI:17009", "name": "GDP-Fuc", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_205683", "map_id": "CHEBI:17009", "name": "GDP-Fuc", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10527865", "map_id": "Q968A5", "name": "nstp-10", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "WBGene00008237", "map_id": "WBGene00008237", "name": "nstp-10", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10527884", "map_id": "none", "name": "SLC35D2 mediates the antiport of GDP-mannose in exchange for GMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_162860", "map_id": "CHEBI:15820", "name": "GDP-Man", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_744239", "map_id": "CHEBI:17345", "name": "guanosine 5'-monophosphate", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_113578", "map_id": "CHEBI:17345", "name": "GMP", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_744233", "map_id": "CHEBI:15820", "name": "GDP-Man", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10527881", "map_id": "Q18779", "name": "sqv-7", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "reaction_10527837", "map_id": "none", "name": "SLC35A2 exchanges UDP-Gal, UDP-GalNAc for UMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_735692", "map_id": "none", "name": "UDP-Gal, UDP-GalNAc", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_735700", "map_id": "CHEBI:16650", "name": "UDP-GalNAc", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_1981137", "map_id": "CHEBI:18307", "name": "UDP-Gal", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_735691", "map_id": "none", "name": "UDP-Gal, UDP-GalNAc", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "species_10527834", "map_id": "Q93890", "name": "srf-3", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "reaction_10527886", "map_id": "none", "name": "SLC35D2 exchanges UDP-sugars for UMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_744229", "map_id": "none", "name": "UDP-GlcNAc, UDP-Glc", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_173594", "map_id": "CHEBI:18066", "name": "UDP-Glc", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_744234", "map_id": "none", "name": "UDP-GlcNAc, UDP-Glc", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "reaction_10508358", "map_id": "none", "name": "Binding of ADAR2 homodimer to dsRNA duplex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_75086", "map_id": "none", "name": "dsRNA duplex", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10508354", "map_id": "none", "name": "ADAR2 homodimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q22618", "map_id": "Q22618", "name": "adr-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000080", "map_id": "WBGene00000080", "name": "adr-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10508356", "map_id": "none", "name": "Editosome (ADAR2) complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10508826", "map_id": "none", "name": "Formation of ADAR1 homodimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10507129", "map_id": "none", "name": "Homologues of ADAR", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q93412", "map_id": "Q93412", "name": "ADAR", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008397", "map_id": "WBGene00008397", "name": "ADAR", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9U3D6", "map_id": "Q9U3D6", "name": "adr-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000079", "map_id": "WBGene00000079", "name": "adr-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10507131", "map_id": "none", "name": "ADAR1 homodimer ", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10508828", "map_id": "none", "name": "Formation of ADAR2 homodimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10508352", "map_id": "Q22618", "name": "adr-2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10507135", "map_id": "none", "name": "Binding of ADAR1 homodimer to dsRNA duplex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10507133", "map_id": "none", "name": "Editosome (ADAR1) complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10508368", "map_id": "none", "name": "Deamination at C6 position of adenosine in Editosome (ADAR2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10508365", "map_id": "none", "name": "A to I edited RNA:Editosome (ADAR2) complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_76230", "map_id": "CHEBI:16134", "name": "NH3", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10508363", "map_id": "none", "name": "Deamination at C6 position of adenosine in Editosome (ADAR1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10508360", "map_id": "none", "name": "A to I edited RNA:Editosome (ADAR1) complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10508608", "map_id": "none", "name": "Dissociation of p-T,Y-MAPK1:p-S,T-MAP2K2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10508601", "map_id": "none", "name": "p-S,T-MAP2K2:p-T,Y-MAPK1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10508573", "map_id": "Q10664", "name": "phospho-mek-2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10508599", "map_id": "P39745", "name": "phospho-mpk-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10508579", "map_id": "none", "name": "MAP2K2 binds MAPK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10508577", "map_id": "none", "name": "p-S,T-MAP2K2:MAPK1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10508604", "map_id": "none", "name": "MAP2K2 phosphorylates MAPK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10525426", "map_id": "none", "name": "pyrophosphate + H2O => 2 orthophosphate [mitochondrial]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_159450", "map_id": "CHEBI:29888", "name": "PPi", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10525423", "map_id": "none", "name": "PPA2 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q18680", "map_id": "Q18680", "name": "pyp-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008149", "map_id": "WBGene00008149", "name": "pyp-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_109496", "map_id": "CHEBI:18420", "name": "Mg2+", "type": "catalyst", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10504277", "map_id": "none", "name": "pyrophosphate + H2O => 2 orthophosphate [cytosolic]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10504274", "map_id": "none", "name": "PPA1 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10571313", "map_id": "none", "name": "RHOJ GEFs activate RHOJ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10571305", "map_id": "none", "name": "RHOJ:GDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "O62422", "map_id": "O62422", "name": "crp-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012532", "map_id": "WBGene00012532", "name": "crp-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10571303", "map_id": "none", "name": "RHOJ:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10531723", "map_id": "Q20487", "name": "DOCK8", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00018520", "map_id": "WBGene00018520", "name": "DOCK6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10571310", "map_id": "none", "name": "RHOJ GAPs stimulate RHOJ GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10571307", "map_id": "none", "name": "RHOJ GAPs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "O45611", "map_id": "O45611", "name": "rga-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010374", "map_id": "WBGene00010374", "name": "rga-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "H2KZV6", "map_id": "H2KZV6", "name": "ARHGAP26", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020209", "map_id": "WBGene00020209", "name": "ARHGAP26", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q23130", "map_id": "Q23130", "name": "rga-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012203", "map_id": "WBGene00012203", "name": "rga-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10571008", "map_id": "none", "name": "RHOA binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10571004", "map_id": "none", "name": "RHOA plasma membrane effectors", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "A0A4V0IKG6", "map_id": "A0A4V0IKG6", "name": "gck-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007287", "map_id": "WBGene00007287", "name": "gck-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EDU3", "map_id": "G5EDU3", "name": "pld-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004040", "map_id": "WBGene00004040", "name": "pld-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A4V0ILM7", "map_id": "A0A4V0ILM7", "name": "phospho-pkn-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009793", "map_id": "WBGene00009793", "name": "phospho-pkn-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "D6VPA1", "map_id": "D6VPA1", "name": "daam-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018976", "map_id": "WBGene00018976", "name": "daam-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q17777", "map_id": "Q17777", "name": "RTKN", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007409", "map_id": "WBGene00007409", "name": "RTKN", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q09994", "map_id": "Q09994", "name": "ani-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019608", "map_id": "WBGene00019608", "name": "ani-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O17772", "map_id": "O17772", "name": "pes-7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003980", "map_id": "WBGene00003980", "name": "pes-7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10571006", "map_id": "none", "name": "RHOA:GTP:cytosolic RHOA effectors", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10570947", "map_id": "none", "name": "GDIs block activation of RHOA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10570939", "map_id": "Q20496", "name": "rhi-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00004356", "map_id": "WBGene00004356", "name": "rhi-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10570945", "map_id": "none", "name": "RHOA GDIs:RHOA:GDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q20496", "map_id": "Q20496", "name": "rhi-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10570274", "map_id": "none", "name": "RHOA GEFs activate RHOA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10570271", "map_id": "none", "name": "RHOA GEFs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10570420", "map_id": "none", "name": "RHOA GAPs stimulate RHOA GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10570417", "map_id": "none", "name": "RHOA GAPs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q20498", "map_id": "Q20498", "name": "rrc-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009800", "map_id": "WBGene00009800", "name": "rrc-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O01443", "map_id": "O01443", "name": "rga-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00015303", "map_id": "WBGene00015303", "name": "rga-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A0K3AW57", "map_id": "A0A0K3AW57", "name": "rga-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Y75B7AL.4c", "map_id": "Y75B7AL.4c", "name": "rga-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "U4PAK0", "map_id": "U4PAK0", "name": "rga-9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007064", "map_id": "WBGene00007064", "name": "rga-9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XW53", "map_id": "Q9XW53", "name": "rga-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013135", "map_id": "WBGene00013135", "name": "rga-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q20440", "map_id": "Q20440", "name": "gei-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001559", "map_id": "WBGene00001559", "name": "gei-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EF80", "map_id": "G5EF80", "name": "spv-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00014051", "map_id": "WBGene00014051", "name": "spv-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10570951", "map_id": "none", "name": "RHOA:GTP translocates to the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10570949", "map_id": "none", "name": "RHOA:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10571347", "map_id": "none", "name": "RHOQ GEFs activate RHOQ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10571331", "map_id": "none", "name": "RHOQ:GDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10553913", "map_id": "none", "name": "RHOQ:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10571344", "map_id": "none", "name": "RHOQ GEFs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10571336", "map_id": "none", "name": "RHOQ GAPs stimulate RHOQ GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10571333", "map_id": "none", "name": "RHOQ GAPs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10553928", "map_id": "none", "name": "RHOQ binds GOPC:CFTR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13949", "compartment_display": "Golgi-associated vesicle membrane" }, { "id": "species_10553903", "map_id": "none", "name": "RHOQ:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_13949", "compartment_display": "Golgi-associated vesicle membrane", "complex": "true" }, { "id": "species_10553892", "map_id": "none", "name": "GOPC:CFTR", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_13949", "compartment_display": "Golgi-associated vesicle membrane", "complex": "true" }, { "id": "O18302", "map_id": "O18302", "name": "gopc-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00014101", "map_id": "WBGene00014101", "name": "gopc-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10553905", "map_id": "none", "name": "RHOQ:GTP:GOPC:CFTR", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_13949", "compartment_display": "Golgi-associated vesicle membrane", "complex": "true" }, { "id": "reaction_10571342", "map_id": "none", "name": "RHOQ binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10571338", "map_id": "none", "name": "RHOQ effectors", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q19253", "map_id": "Q19253", "name": "toca-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017298", "map_id": "WBGene00017298", "name": "toca-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XUS7", "map_id": "Q9XUS7", "name": "toca-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010663", "map_id": "WBGene00010663", "name": "toca-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10571340", "map_id": "none", "name": "RHOQ:GTP:RHOQ effectors", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10571470", "map_id": "none", "name": "RHOQ translocates to the Golgi-associated vesicle membranes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10571361", "map_id": "none", "name": "GDIs bind RHOH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10571357", "map_id": "none", "name": "RHOH:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10571359", "map_id": "none", "name": "RHOH:GTP:RHOH GDIs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10571393", "map_id": "none", "name": "RHOH binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10571389", "map_id": "none", "name": "RHOH effectors", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "G5EFU0", "map_id": "G5EFU0", "name": "pak-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006443", "map_id": "WBGene00006443", "name": "pak-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q18462", "map_id": "Q18462", "name": "ZAP70", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016416", "map_id": "WBGene00016416", "name": "ZAP70", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5ECJ6", "map_id": "G5ECJ6", "name": "csk-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000812", "map_id": "WBGene00000812", "name": "csk-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10571391", "map_id": "none", "name": "RHOH:GTP:RHOH effectors", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10571363", "map_id": "none", "name": "RHOH binds GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10571355", "map_id": "none", "name": "Homologues of RHOH", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10571418", "map_id": "none", "name": "RHOU binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10571400", "map_id": "none", "name": "RHOU:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q19739", "map_id": "Q19739", "name": "chw-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009059", "map_id": "WBGene00009059", "name": "chw-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10571414", "map_id": "none", "name": "RHOU effectors", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q95PX0", "map_id": "Q95PX0", "name": "nck-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006410", "map_id": "WBGene00006410", "name": "nck-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10571416", "map_id": "none", "name": "RHOU:GTP:RHOU effectors", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10571423", "map_id": "none", "name": "RHOU auto-activates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10571420", "map_id": "none", "name": "RHOU:GDP", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10571105", "map_id": "none", "name": "RAC1 GDIs block activation of RAC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10571103", "map_id": "none", "name": "RAC1:GDP:RAC1 GDIs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10573125", "map_id": "none", "name": "RAC1 translocates to the endoplasmic reticulum membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10573123", "map_id": "none", "name": "RAC1:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10571067", "map_id": "none", "name": "RAC1 GAPs stimulate RAC1 GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10571064", "map_id": "none", "name": "RAC1 GAPs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P34288", "map_id": "P34288", "name": "pac-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00015418", "map_id": "WBGene00015418", "name": "pac-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XVI0", "map_id": "Q9XVI0", "name": "rlbp-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011970", "map_id": "WBGene00011970", "name": "rlbp-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P46941", "map_id": "P46941", "name": "tag-325", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008006", "map_id": "WBGene00008006", "name": "tag-325", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A2K5AU23", "map_id": "A0A2K5AU23", "name": "rga-8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021324", "map_id": "WBGene00021324", "name": "rga-8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q965N4", "map_id": "Q965N4", "name": "chin-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00015267", "map_id": "WBGene00015267", "name": "chin-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86NH1", "map_id": "Q86NH1", "name": "syd-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006363", "map_id": "WBGene00006363", "name": "syd-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q19370", "map_id": "Q19370", "name": "srgp-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006406", "map_id": "WBGene00006406", "name": "srgp-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10571101", "map_id": "none", "name": "RAC1 binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10571097", "map_id": "none", "name": "RAC1 effectors", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "O44518", "map_id": "O44518", "name": "gex-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001579", "map_id": "WBGene00001579", "name": "gex-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O01583", "map_id": "O01583", "name": "mrck-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006437", "map_id": "WBGene00006437", "name": "mrck-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q18879", "map_id": "Q18879", "name": "cav-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000302", "map_id": "WBGene00000302", "name": "cav-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q94051", "map_id": "Q94051", "name": "cav-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000301", "map_id": "WBGene00000301", "name": "cav-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9BL72", "map_id": "Q9BL72", "name": "frl-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021698", "map_id": "WBGene00021698", "name": "frl-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q17865", "map_id": "Q17865", "name": "PARD6A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007486", "map_id": "WBGene00007486", "name": "PARD6A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9NAN2", "map_id": "Q9NAN2", "name": "par-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003921", "map_id": "WBGene00003921", "name": "par-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A5Z2X2", "map_id": "A5Z2X2", "name": "BRK1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00303007", "map_id": "WBGene00303007", "name": "BRK1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P55163", "map_id": "P55163", "name": "gex-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001580", "map_id": "WBGene00001580", "name": "gex-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XVK6", "map_id": "Q9XVK6", "name": "wve-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006958", "map_id": "WBGene00006958", "name": "wve-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q10929", "map_id": "Q10929", "name": "phospho-abi-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00015146", "map_id": "WBGene00015146", "name": "phospho-abi-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10571099", "map_id": "none", "name": "RAC1:GTP:RAC1 effectors", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10571020", "map_id": "none", "name": "RAC1 GEFs activate RAC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10571017", "map_id": "none", "name": "RAC1 GEFs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "X5LX76", "map_id": "X5LX76", "name": "tag-77", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006450", "map_id": "WBGene00006450", "name": "tag-77", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10571433", "map_id": "none", "name": "RHOV binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10571429", "map_id": "none", "name": "RHOV effectors", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10571427", "map_id": "none", "name": "RHOV:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10571431", "map_id": "none", "name": "RHOV:GTP:RHOV effectors", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10571437", "map_id": "none", "name": "RHOV binds GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10571435", "map_id": "none", "name": "RHOV:GDP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10571156", "map_id": "none", "name": "CDC42 GAPs stimulate CDC42 GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10571134", "map_id": "none", "name": "CDC42:GDP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10571153", "map_id": "none", "name": "CDC42 GAPs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "H2KZV4", "map_id": "H2KZV4", "name": "ARAP3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017760", "map_id": "WBGene00017760", "name": "ARAP3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10571142", "map_id": "none", "name": "CDC42 GDIs block activation of CDC42", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10571138", "map_id": "none", "name": "CDC42 GDIs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10571140", "map_id": "none", "name": "CDC42:GDP:CDC42 GDIs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10573129", "map_id": "none", "name": "CDC42 translocates to the endoplasmic reticulum membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10573127", "map_id": "none", "name": "CDC42:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10571149", "map_id": "none", "name": "CDC42 GEFs activate CDC42", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10571146", "map_id": "none", "name": "CDC42 GEFs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "G5ECK4", "map_id": "G5ECK4", "name": "DNMBP", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00044989", "map_id": "WBGene00044989", "name": "DNMBP", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10571217", "map_id": "none", "name": "RHOD:GTP translocates to the endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10571194", "map_id": "none", "name": "RHOD:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10554702", "map_id": "none", "name": "RHOD:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "true" }, { "id": "reaction_10573201", "map_id": "none", "name": "RHOD translocates to the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10573199", "map_id": "none", "name": "RHOD:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "reaction_10573187", "map_id": "none", "name": "RHOD translocates to the mitochondrial outer membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10573185", "map_id": "none", "name": "RHOD:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "true" }, { "id": "reaction_10571202", "map_id": "none", "name": "RHOD GAPs stimulate RHOD GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10571190", "map_id": "none", "name": "RHOD:GDP", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10571199", "map_id": "none", "name": "RHOD GAPs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10573195", "map_id": "none", "name": "RHOD binds effectors at the mitochondrial outer membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane" }, { "id": "species_10573191", "map_id": "none", "name": "RHOD mitochondrial outer membrane effectors", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10573193", "map_id": "none", "name": "RHOD:GTP:RHOD mitochondrial outer membrane effectors", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "true" }, { "id": "reaction_10571197", "map_id": "none", "name": "RHOD auto-activates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10573181", "map_id": "none", "name": "RHOD binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10573177", "map_id": "none", "name": "RHOD plasma membrane effectors", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q23158", "map_id": "Q23158", "name": "atn-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000228", "map_id": "WBGene00000228", "name": "atn-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q23146", "map_id": "Q23146", "name": "rab-7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004271", "map_id": "WBGene00004271", "name": "rab-7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O02163", "map_id": "O02163", "name": "TOR1AIP1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020376", "map_id": "WBGene00020376", "name": "TOR1AIP1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7K7J0", "map_id": "Q7K7J0", "name": "gei-18", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001575", "map_id": "WBGene00001575", "name": "gei-18", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XUB9", "map_id": "Q9XUB9", "name": "nra-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012128", "map_id": "WBGene00012128", "name": "nra-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q20952", "map_id": "Q20952", "name": "add-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9U9K0", "map_id": "Q9U9K0", "name": "add-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000072", "map_id": "WBGene00000072", "name": "add-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9U2A6", "map_id": "Q9U2A6", "name": "efhd-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012980", "map_id": "WBGene00012980", "name": "efhd-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "B3WFV9", "map_id": "B3WFV9", "name": "abts-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009920", "map_id": "WBGene00009920", "name": "abts-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q58QG8", "map_id": "Q58QG8", "name": "abts-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019844", "map_id": "WBGene00019844", "name": "abts-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O02495", "map_id": "O02495", "name": "snb-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004897", "map_id": "WBGene00004897", "name": "snb-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "H2KY90", "map_id": "H2KY90", "name": "vang-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00015171", "map_id": "WBGene00015171", "name": "vang-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A679L8R0", "map_id": "A0A679L8R0", "name": "esyt-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020443", "map_id": "WBGene00020443", "name": "esyt-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10573179", "map_id": "none", "name": "RHOD:GTP:RHOD plasma membrane effectors", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10571215", "map_id": "none", "name": "RHOD binds effectors at the endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10571211", "map_id": "none", "name": "RHOD endosome effectors", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10571213", "map_id": "none", "name": "RHOD:GTP:RHOD endosome effectors", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "true" }, { "id": "reaction_10571267", "map_id": "none", "name": "RAC2 GEFs activate RAC2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10571245", "map_id": "none", "name": "RAC2:GDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10509471", "map_id": "none", "name": "RAC2:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10571264", "map_id": "none", "name": "RAC2 GEFs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "G5EEN3", "map_id": "G5EEN3", "name": "ced-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000419", "map_id": "WBGene00000419", "name": "ced-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10571251", "map_id": "none", "name": "RAC2 GDIs block activation of RAC2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10571249", "map_id": "none", "name": "ARHGDIA:RAC2:GDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10571269", "map_id": "none", "name": "RAC2 translocates to the phagocytic vesicle membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10554742", "map_id": "none", "name": "RAC2:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_1222693", "compartment_display": "phagocytic vesicle membrane", "complex": "true" }, { "id": "reaction_10573381", "map_id": "none", "name": "RAC2 translocates to the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10573379", "map_id": "none", "name": "RAC2:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10571257", "map_id": "none", "name": "RAC2 binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10571253", "map_id": "none", "name": "RAC2 plasma membrane effectors", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10571255", "map_id": "none", "name": "RAC2:GTP:RAC2 cytosolic effectors", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10573369", "map_id": "none", "name": "RAC2 binds effectors at the mitochondrial outer membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane" }, { "id": "species_10573348", "map_id": "none", "name": "RAC2:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "true" }, { "id": "species_10573365", "map_id": "none", "name": "RAC2 mitochondrial effectors", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "false" }, { "id": "species_10573367", "map_id": "none", "name": "RAC2:GTP:RAC2 mitochondrial effectors", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "true" }, { "id": "reaction_10573371", "map_id": "none", "name": "RAC2 translocates to the mitochondrial membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10571262", "map_id": "none", "name": "RAC2 GAPs stimulate RAC2 GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10571259", "map_id": "none", "name": "RAC2 GAPs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10573170", "map_id": "none", "name": "RHOF binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10573166", "map_id": "none", "name": "RHOF effectors", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "O17905", "map_id": "O17905", "name": "frm-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001490", "map_id": "WBGene00001490", "name": "frm-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10573139", "map_id": "none", "name": "RHOF:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10573168", "map_id": "none", "name": "RHOF:GTP:RHOF effectors", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10573142", "map_id": "none", "name": "RHOF auto-activates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10573137", "map_id": "none", "name": "RHOF:GDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10573206", "map_id": "none", "name": "RHOF GAPs stimulate RHOF GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10573203", "map_id": "none", "name": "RHOF GAPs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10553794", "map_id": "none", "name": "IQGAPs bind F-actin, which is inhibited by calmodulin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10523755", "map_id": "none", "name": "F-actin", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P0DM41", "map_id": "P0DM41", "name": "act-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000063", "map_id": "WBGene00000063", "name": "act-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P0DM42", "map_id": "P0DM42", "name": "act-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000065", "map_id": "WBGene00000065", "name": "act-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P10984", "map_id": "P10984", "name": "act-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000064", "map_id": "WBGene00000064", "name": "act-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P10986", "map_id": "P10986", "name": "act-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000066", "map_id": "WBGene00000066", "name": "act-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10553786", "map_id": "none", "name": "RAC1,CDC42:GTP:IQGAPs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10553790", "map_id": "none", "name": "RAC1,CDC42:GTP:IQGAP:F-actin", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10553792", "map_id": "none", "name": "RAC1:GTP,CDC42:GTP:IQGAPs:CALM1:4Ca2+", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10553797", "map_id": "none", "name": "IQGAPs bind CALM1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10515137", "map_id": "none", "name": "CALM1:4Ca2+", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10553788", "map_id": "none", "name": "GTP-bound RAC1 and CDC42 bind IQGAPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10553784", "map_id": "none", "name": "IQGAP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10520664", "map_id": "none", "name": "CDC42:GTP, RAC1:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10553925", "map_id": "none", "name": "RHOQ positively regulates trafficking of GOPC:CFTR to the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13949", "compartment_display": "Golgi-associated vesicle membrane" }, { "id": "species_10553923", "map_id": "none", "name": "RHOQ:GTP:GOPC:CFTR", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10553944", "map_id": "none", "name": "GOPC promotes translocation of CFTR to lysosomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13949", "compartment_display": "Golgi-associated vesicle membrane" }, { "id": "species_10553942", "map_id": "none", "name": "GOPC:CFTR", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "reaction_10554706", "map_id": "none", "name": "RHOD:GTP recruits DAIPH2-3 to endosomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10554698", "map_id": "none", "name": "DIAPH2-3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10554704", "map_id": "none", "name": "RHOD:GTP:DIAPH2-3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "true" }, { "id": "reaction_10554612", "map_id": "none", "name": "FMNL2 binds CDC42:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10554608", "map_id": "none", "name": "FMNL2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P34489", "map_id": "P34489", "name": "fozi-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010453", "map_id": "WBGene00010453", "name": "fozi-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10554610", "map_id": "none", "name": "CDC42:GTP:FMNL2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10548325", "map_id": "none", "name": "DAAM1 recruits GTP-bound RHOA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10548317", "map_id": "none", "name": "ppDVL:DAAM1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "A0A0K3AUI8", "map_id": "A0A0K3AUI8", "name": "phospho-dsh-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "C34F11.9e", "map_id": "C34F11.9e", "name": "phospho-dsh-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q18239", "map_id": "Q18239", "name": "phospho-dsh-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001102", "map_id": "WBGene00001102", "name": "phospho-dsh-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q22227", "map_id": "Q22227", "name": "phospho-mig-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003241", "map_id": "WBGene00003241", "name": "phospho-mig-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10548321", "map_id": "none", "name": "RHOA:GTP:Mg2+", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10548323", "map_id": "none", "name": "ppDVL:DAAM1:RHOA:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10554694", "map_id": "none", "name": "DIAPH1 binds RHOA:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10554686", "map_id": "none", "name": "DIAPH1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10554710", "map_id": "none", "name": "RHOD:GTP:DIAPH2-3 recruits SRC-1 to endosomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10554708", "map_id": "none", "name": "RHOD:GTP:DIAPH2:SRC-1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "true" }, { "id": "reaction_10554633", "map_id": "none", "name": "SRGAP2 binds RAC1:GTP:FMNL1:profilin:G-actin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10554629", "map_id": "Q19370", "name": "srgp-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10554624", "map_id": "none", "name": "RAC1:GTP:FMNL1:Profilin:G-actin", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10554631", "map_id": "none", "name": "SRGAP2:RAC1:GTP:FMNL1:Profilin:G-actin", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10548319", "map_id": "none", "name": "ppDVL binds DAAM1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10548315", "map_id": "D6VPA1", "name": "daam-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10548290", "map_id": "none", "name": "pp-DVL", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10554723", "map_id": "none", "name": "RHOA:GTP:RTKN binds LIN7B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10554719", "map_id": "none", "name": "RHOA:GTP:RTKN", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10519885", "map_id": "A5PEX5", "name": "lin-7", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "WBGene00002996", "map_id": "WBGene00002996", "name": "lin-7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10554721", "map_id": "none", "name": "RHOA:GTP:RTKN:LIN7B", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "A5PEX5", "map_id": "A5PEX5", "name": "lin-7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10554732", "map_id": "none", "name": "RHOA:GTP:RTKN binds TAX1BP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10554728", "map_id": "Q09506", "name": "txbp-3", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00016678", "map_id": "WBGene00016678", "name": "txbp-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10554730", "map_id": "none", "name": "RHOA:GTP:RTKN:TAX1BP3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q09506", "map_id": "Q09506", "name": "txbp-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10559350", "map_id": "none", "name": "PIK3C3:PIK3R4 phosphorylates PI to PI3P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_1222693", "compartment_display": "phagocytic vesicle membrane" }, { "id": "species_1524165", "map_id": "CHEBI:16749", "name": "PI", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_1629751", "map_id": "CHEBI:17283", "name": "PI3P", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10559347", "map_id": "none", "name": "PIK3C3:PIK3R4", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_1222693", "compartment_display": "phagocytic vesicle membrane", "complex": "true" }, { "id": "reaction_10554803", "map_id": "none", "name": "NF2 binds PAK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10542001", "map_id": "H2KYX3", "name": "nfm-1", "type": "inhibitor", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "WBGene00003593", "map_id": "WBGene00003593", "name": "nfm-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10520672", "map_id": "none", "name": "PAK1 dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10554801", "map_id": "none", "name": "PAK1:NF2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "H2KYX3", "map_id": "H2KYX3", "name": "nfm-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10542003", "map_id": "none", "name": "RAC1 and CDC42 activate PAK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10541994", "map_id": "none", "name": "RAC1:GTP,CDC42:GTP:PAK1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10553954", "map_id": "none", "name": "Autophosphorylation of PAK1,2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10553951", "map_id": "none", "name": "CDC42:GTP,RAC1:GTP:PAK1,PAK2,PAK3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10521284", "map_id": "none", "name": "p-S,T-PAK1,2,3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10554822", "map_id": "none", "name": "PAK1 phosphorylates FLNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10554807", "map_id": "none", "name": "p-S144,T423-PAK1:FLNA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10521268", "map_id": "none", "name": "Homologues of p-S144,T423-PAK1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10554819", "map_id": "none", "name": "p-S2152-FLNA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10554809", "map_id": "none", "name": "FLNA binds PAK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10554805", "map_id": "none", "name": "FLNA", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10570440", "map_id": "none", "name": "RAC1 and CDC42 activate PAK3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10520684", "map_id": "none", "name": "PAK3 dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10553949", "map_id": "none", "name": "CDC42:GTP,RAC1:GTP:PAK3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10520682", "map_id": "Q17850", "name": "pak-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10570442", "map_id": "none", "name": "RAC1 and CDC42 activate PAK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10520680", "map_id": "none", "name": "PAK2 dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10553947", "map_id": "none", "name": "CDC42:GTP,RAC1:GTP:PAK2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10520678", "map_id": "none", "name": "Homologues of PAK2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10554783", "map_id": "none", "name": "PAK2 phosphorylates myosin regulatory light chain (MRLC)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10554760", "map_id": "none", "name": "Smooth muscle/non-muscle myosin II", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q20641", "map_id": "Q20641", "name": "nmy-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003776", "map_id": "WBGene00003776", "name": "nmy-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EBY3", "map_id": "G5EBY3", "name": "nmy-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003777", "map_id": "WBGene00003777", "name": "nmy-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P19625", "map_id": "P19625", "name": "phospho-mlc-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003369", "map_id": "WBGene00003369", "name": "phospho-mlc-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P19626", "map_id": "P19626", "name": "phospho-mlc-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003370", "map_id": "WBGene00003370", "name": "phospho-mlc-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q09510", "map_id": "Q09510", "name": "phospho-mlc-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003372", "map_id": "WBGene00003372", "name": "phospho-mlc-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q20238", "map_id": "Q20238", "name": "cal-7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009585", "map_id": "WBGene00009585", "name": "cal-7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q21201", "map_id": "Q21201", "name": "mlc-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010554", "map_id": "WBGene00010554", "name": "mlc-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q69Z12", "map_id": "Q69Z12", "name": "mlc-7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00023451", "map_id": "WBGene00023451", "name": "mlc-7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XVI9", "map_id": "Q9XVI9", "name": "mlc-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011734", "map_id": "WBGene00011734", "name": "mlc-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P53014", "map_id": "P53014", "name": "mlc-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003371", "map_id": "WBGene00003371", "name": "mlc-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10554780", "map_id": "none", "name": "p-T19-MRLC-Smooth muscle/non-muscle myosin II", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10521278", "map_id": "none", "name": "Homologues of p-S141,T402-PAK2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10554799", "map_id": "none", "name": "PAK1 phosphorylates myosin phosphatase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10554791", "map_id": "none", "name": "Myosin phosphatase", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q27497", "map_id": "Q27497", "name": "gsp-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001747", "map_id": "WBGene00001747", "name": "gsp-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5ECD7", "map_id": "G5ECD7", "name": "phospho-mel-11", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003196", "map_id": "WBGene00003196", "name": "phospho-mel-11", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10554796", "map_id": "none", "name": "p-T696-PPP1R12A-Myosin phosphatase", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10554832", "map_id": "none", "name": "p-T774-PKN1 binds CDC25C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10553254", "map_id": "A0A4V0ILM7", "name": "phospho-pkn-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10509856", "map_id": "Q21762", "name": "cdc-25.4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10554830", "map_id": "none", "name": "p-T774-PKN1:CDC25C", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q21762", "map_id": "Q21762", "name": "cdc-25.4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10507073", "map_id": "none", "name": "Association of p-S216-CDC25C with 14-3-3 proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10507069", "map_id": "none", "name": "14-3-3 dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10507019", "map_id": "Q21762", "name": "phospho-cdc-25.4", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10507071", "map_id": "none", "name": "p-S216-CDC25C:14-3-3 protein complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10554835", "map_id": "none", "name": "p-T774-PKN1 phosphorylates CDC25C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10554850", "map_id": "none", "name": "p-T38-PPP1R14A binds MLCP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10554843", "map_id": "Q7YX00", "name": "phospho-p-T38-PPP1R14A", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00010109", "map_id": "WBGene00010109", "name": "phospho-p-T38-PPP1R14A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10554848", "map_id": "none", "name": "MLCP:p-T38-PPP1R14A", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q7YX00", "map_id": "Q7YX00", "name": "phospho-p-T38-PPP1R14A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10553239", "map_id": "none", "name": "RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10553227", "map_id": "A0A4V0ILM7", "name": "pkn-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10553235", "map_id": "none", "name": "RHOA,RHOB,RHOC,RAC1:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10553237", "map_id": "none", "name": "RHOA,RHOB,RHOC,RAC1:GTP:PKN1-3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10553243", "map_id": "none", "name": "RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10553241", "map_id": "none", "name": "RHOA,RHOB,RHOC,RAC1:GTP:PKN1-3:PDPK1:PIP3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10553263", "map_id": "none", "name": "PDPK1 phosphorylates PKN1,2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10553760", "map_id": "none", "name": "KDM4C demethylates Me3K-10-H3 associated with KLK2 and KLK3 promoters", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10553745", "map_id": "none", "name": "p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with p-T12, Me3K-10-H3:KDM4C", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_469662", "map_id": "CHEBI:16330", "name": "DHTEST", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "CHEBI:29117", "map_id": "CHEBI:29117", "name": "CHEBI:29117", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_193057", "map_id": "CHEBI:17347", "name": "TEST", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_193079", "map_id": "CHEBI:16422", "name": "ANDST", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "K7ZUH9", "map_id": "K7ZUH9", "name": "his-40", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001914", "map_id": "WBGene00001914", "name": "his-40", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q10453", "map_id": "Q10453", "name": "his-71", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001945", "map_id": "WBGene00001945", "name": "his-71", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10553757", "map_id": "none", "name": "p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with p-T12-Me2K-10-H3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10549605", "map_id": "Q9U297", "name": "jmjd-2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10553747", "map_id": "none", "name": "Demethylase KDM4C binds KLK2 and KLK3 promoters", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10553740", "map_id": "none", "name": "p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with p-T12,Me3K-10-H3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10553743", "map_id": "none", "name": "PKN1 phosphorylates histone 3 of nucleosomes associate with KLK2 and KLK3 promoters", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10553726", "map_id": "none", "name": "p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with Me3K-10-H3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10554846", "map_id": "none", "name": "p-T774-PKN1 phosphorylates PPP1R14A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10554840", "map_id": "Q7YX00", "name": "PPP1R14A", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10542752", "map_id": "none", "name": "ABL phosphorylates WAVEs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10542749", "map_id": "none", "name": "WRC:IRSp53/58:RAC1:GTP:PIP3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10542068", "map_id": "none", "name": "p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10519289", "map_id": "P03949", "name": "abl-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00000018", "map_id": "WBGene00000018", "name": "abl-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10542112", "map_id": "none", "name": "Branching and elongation of mother and daughter filaments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10542110", "map_id": "none", "name": "Mother filament:ARP2/3:actin:ADP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P58798", "map_id": "P58798", "name": "arx-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000204", "map_id": "WBGene00000204", "name": "arx-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A3P6PCS5", "map_id": "A0A3P6PCS5", "name": "arx-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000201", "map_id": "WBGene00000201", "name": "arx-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9N4I0", "map_id": "Q9N4I0", "name": "arx-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000199", "map_id": "WBGene00000199", "name": "arx-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8WTM6", "map_id": "Q8WTM6", "name": "arx-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021170", "map_id": "WBGene00021170", "name": "arx-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P53489", "map_id": "P53489", "name": "arx-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000200", "map_id": "WBGene00000200", "name": "arx-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XWV3", "map_id": "Q9XWV3", "name": "arx-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000203", "map_id": "WBGene00000203", "name": "arx-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O61861", "map_id": "O61861", "name": "arx-7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000205", "map_id": "WBGene00000205", "name": "arx-7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P91167", "map_id": "P91167", "name": "ARPC5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016729", "map_id": "WBGene00016729", "name": "ARPC5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10515381", "map_id": "none", "name": "G-actin", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10537825", "map_id": "none", "name": "Mother filament:branching complex:daughter filament", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10542085", "map_id": "none", "name": "p-ERK phosphorylates WAVEs and ABI", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10542054", "map_id": "none", "name": "p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10543483", "map_id": "none", "name": "Detachment of WASP/WAVE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10542074", "map_id": "none", "name": "Mother filament:branching complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10542070", "map_id": "none", "name": "WAVE2, WASP, N-WASP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10542076", "map_id": "none", "name": "(WASPs, WAVE):G-actin:ARP2/3 binds F-actin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10542072", "map_id": "none", "name": "WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10571243", "map_id": "none", "name": "TXLNA (IL14) binds syntaxin3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10525375", "map_id": "Q22666", "name": "TXLNA", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00011917", "map_id": "WBGene00011917", "name": "TXLNA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10571239", "map_id": "none", "name": "Homologues of STX3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q20024", "map_id": "Q20024", "name": "syx-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006371", "map_id": "WBGene00006371", "name": "syx-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q20574", "map_id": "Q20574", "name": "syx-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006372", "map_id": "WBGene00006372", "name": "syx-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O16000", "map_id": "O16000", "name": "unc-64", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006798", "map_id": "WBGene00006798", "name": "unc-64", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10571241", "map_id": "none", "name": "TXLNA:STX3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q22666", "map_id": "Q22666", "name": "TXLNA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10525389", "map_id": "none", "name": "TXLNA (IL14) binds syntaxin1A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10516749", "map_id": "O16000", "name": "unc-64", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10525377", "map_id": "none", "name": "TXLNA:STX1A", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10525387", "map_id": "none", "name": "STXA1:SNAP25,STXBP2, VAMP2", "type": "inhibitor", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "G5EEN8", "map_id": "G5EEN8", "name": "aex-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006454", "map_id": "WBGene00006454", "name": "aex-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A5PEW5", "map_id": "A5PEW5", "name": "ric-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004364", "map_id": "WBGene00004364", "name": "ric-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O44412", "map_id": "O44412", "name": "phospho-p-STXBP3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020298", "map_id": "WBGene00020298", "name": "phospho-p-STXBP3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34815", "map_id": "P34815", "name": "unc-18", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006757", "map_id": "WBGene00006757", "name": "unc-18", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10528533", "map_id": "none", "name": "CBL:CRKL binds RAPGEF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10528524", "map_id": "none", "name": "p(Y700,731,774)-CBL:CRK", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q19019", "map_id": "Q19019", "name": "sli-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004829", "map_id": "WBGene00004829", "name": "sli-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10528531", "map_id": "none", "name": "p(Y700,731,774)-CBL:CRK:RAPGEF1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10528518", "map_id": "none", "name": "CBL ubiquitinates PI3K", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10528462", "map_id": "none", "name": "FYN-like kinases:p(Y731)-CBL:GRB2:p85-containing Class 1A PI3Ks", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10528505", "map_id": "none", "name": "K48polyUb", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10528516", "map_id": "none", "name": "FYN-like kinases:p(Y731)-CBL:GRB2:Ubiquitinated p85-containing Class 1A PI3Ks", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10528535", "map_id": "none", "name": "CBL binds CRK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10528460", "map_id": "Q19019", "name": "phospho-sli-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10528266", "map_id": "none", "name": "CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10512267", "map_id": "Q19019", "name": "sli-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10506871", "map_id": "P29355", "name": "sem-5", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10528262", "map_id": "none", "name": "FYN-like kinases", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10528264", "map_id": "none", "name": "FYN-like kinases:CBL:GRB2:p85-containing Class 1A PI3Ks", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10528522", "map_id": "none", "name": "CBL binds VAV", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10516075", "map_id": "Q45FX5", "name": "vav-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10528520", "map_id": "none", "name": "p(Y700,731,774)-CBL:VAV1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10531907", "map_id": "none", "name": "STAT1 and STAT3 dimers translocate to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10531891", "map_id": "none", "name": "p-Y701-STAT1 dimer,p-Y705-STAT3 dimer,p-Y701-STAT1:p-Y705-STAT3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10531905", "map_id": "none", "name": "STAT1/3 homo and heterodimers", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10531893", "map_id": "none", "name": "Phosphorylated STAT1, STAT3 form dimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10531885", "map_id": "none", "name": "p-Y701-STAT1, p-Y705-STAT3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10573100", "map_id": "none", "name": "IL6R binds IL6R inhibitors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10573096", "map_id": "Q9UB28", "name": "let-805", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_9715042", "map_id": "none", "name": "IL6R inhibitors", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10573098", "map_id": "none", "name": "IL6R:IL6R inhibitors", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10558097", "map_id": "none", "name": "p-Y705-STAT3 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10531887", "map_id": "none", "name": "p-Y705-STAT3 dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10558095", "map_id": "none", "name": "p-Y705-STAT3 dimer translocates from cytosol to nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10531903", "map_id": "none", "name": "p-Y705-STAT3 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10570566", "map_id": "none", "name": "p-Y701-STAT1 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10570562", "map_id": "none", "name": "Homologues of p-Y701-STAT1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10570564", "map_id": "none", "name": "p-Y-STAT1 dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10570584", "map_id": "none", "name": "p-Y701-STAT1:p-Y705-STAT3 translocates from the cytosol to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10570572", "map_id": "none", "name": "p-Y701-STAT1:p-Y705-STAT3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10570582", "map_id": "none", "name": "p-Y701-STAT1:p-Y705-STAT3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10570570", "map_id": "none", "name": "p-Y649-STAT5A, p-STAT5B dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10570568", "map_id": "none", "name": "p-STAT5A,p-STAT5B dimer", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10570574", "map_id": "none", "name": "p-Y701-STAT1 binds p-Y705-STAT3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10570611", "map_id": "none", "name": "p-STAT1 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10569000", "map_id": "none", "name": "Homologues of p-STAT1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10570609", "map_id": "none", "name": "2 x p-STAT1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10570643", "map_id": "none", "name": "p-STAT1 dimer translocates from the cytosol to the nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10570641", "map_id": "none", "name": "2 x p-STAT1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10570629", "map_id": "none", "name": "p-STAT3 dimer translocates from cytosol to nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10570619", "map_id": "none", "name": "2 x p-STAT3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10570627", "map_id": "none", "name": "2xp-STAT3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10570633", "map_id": "none", "name": "p-STAT3 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10570617", "map_id": "none", "name": "Homologues of p-STAT3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10558321", "map_id": "none", "name": "p-Y-STATs dimerize", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10558317", "map_id": "none", "name": "p-Y701-STAT1,p-Y705-STAT3,p-Y641-STAT6", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10558319", "map_id": "none", "name": "p-Y701-STAT1 dimer,p-Y705-STAT3 dimer,p-Y641-STAT6 dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10558499", "map_id": "none", "name": "Expression of HSP90B1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_10558497", "map_id": "Q22235", "name": "enpl-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "WBGene00011480", "map_id": "WBGene00011480", "name": "phospho-enpl-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10558325", "map_id": "none", "name": "p-Y-STATs translocate to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10558323", "map_id": "none", "name": "p-Y701-STAT1 dimer,p-Y705-STAT3 dimer,p-Y641-STAT6 dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10558148", "map_id": "none", "name": "p-Y705-STAT3, p-Y641-STAT6 dimerise", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10558142", "map_id": "none", "name": "p-Y705-STAT3,p-Y641-STAT6", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10558146", "map_id": "none", "name": "p-Y705-STAT3 dimer, p-Y614-STAT6 dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10558206", "map_id": "none", "name": "p-Y705-STAT3 dimer, p-Y641-STAT6 dimer translocate to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10558204", "map_id": "none", "name": "p-Y705-STAT3 dimer, p-Y641-STAT6 dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10570774", "map_id": "none", "name": "STAT3 phosphorylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10519913", "map_id": "none", "name": "Homologues of STAT3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10526186", "map_id": "none", "name": "Pellino ubiquitinates IRAK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10526177", "map_id": "none", "name": "hp-IRAK1: p-Pellino-1,2,(3):UBE2N:UBE2V1:K63polyUb", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q22967", "map_id": "Q22967", "name": "phospho-peli-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017766", "map_id": "WBGene00017766", "name": "phospho-peli-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10526183", "map_id": "none", "name": "K63polyUb-hp-IRAK1:p-Pellino-1,2,(3):UBE2N:UBE2V1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10525239", "map_id": "none", "name": "Formation of caspase-1 p10/p20 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10525229", "map_id": "none", "name": "Homologues of CASP1(317-404)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "G5EBM1", "map_id": "G5EBM1", "name": "phospho-csp-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000819", "map_id": "WBGene00000819", "name": "phospho-csp-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10525235", "map_id": "none", "name": "Homologues of CASP1(120-297)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10525237", "map_id": "none", "name": "CASP1(120-197):CASP1(317-404)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10525261", "map_id": "none", "name": "Caspase-1 active tetramer formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10525259", "map_id": "none", "name": "Caspase-1 tetramer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10570684", "map_id": "none", "name": "MAPK8 phosphorylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10510931", "map_id": "Q8WQG9", "name": "jnk-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10510951", "map_id": "Q8WQG9", "name": "phospho-jnk-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10533055", "map_id": "none", "name": "GHBP binds GHR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10530700", "map_id": "Q9UB28", "name": "let-805", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10533051", "map_id": "Q9UB28", "name": "let-805", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10533053", "map_id": "none", "name": "GHBP:GHR", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10543479", "map_id": "none", "name": "MTMR4 dephosphorylates SMAD2/3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10543476", "map_id": "none", "name": "p-2S-SMAD2/3:MTMR4", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_171062", "compartment_display": "early endosome membrane", "complex": "true" }, { "id": "Q22712", "map_id": "Q22712", "name": "mtm-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q21733", "map_id": "Q21733", "name": "phospho-daf-8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000904", "map_id": "WBGene00000904", "name": "phospho-daf-8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10543474", "map_id": "Q22712", "name": "mtm-3", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_171062", "compartment_display": "early endosome membrane", "complex": "false" }, { "id": "species_10511457", "map_id": "Q21733", "name": "daf-8", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10543464", "map_id": "none", "name": "STUB1 (CHIP) ubiquitinates SMAD3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10543459", "map_id": "none", "name": "SMAD3:STUB1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "G5ECY6", "map_id": "G5ECY6", "name": "chn-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000500", "map_id": "WBGene00000500", "name": "chn-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10543461", "map_id": "none", "name": "Ub-SMAD3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10530864", "map_id": "G5ECY6", "name": "chn-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10543481", "map_id": "none", "name": "MTMR4 binds phosphorylated SMAD2/3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10511411", "map_id": "Q21733", "name": "phospho-daf-8", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10543466", "map_id": "none", "name": "SMAD3 binds STUB1 (CHIP)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10511459", "map_id": "Q21733", "name": "daf-8", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10543468", "map_id": "none", "name": "Degradation of ubiquitinated SMAD3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10543389", "map_id": "none", "name": "Degradation of ubiquitinated SMAD2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10543387", "map_id": "none", "name": "Ub-SMAD2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10543310", "map_id": "none", "name": "Degradation of TGF-beta receptor complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10543308", "map_id": "none", "name": "TGFB1:TGFBR2:Ub-p-TGFBR1:Ub-SMAD7", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "P20792", "map_id": "P20792", "name": "phospho-daf-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000897", "map_id": "WBGene00000897", "name": "phospho-daf-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EDS9", "map_id": "G5EDS9", "name": "tag-68", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006445", "map_id": "WBGene00006445", "name": "tag-68", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10512054", "map_id": "none", "name": "Secretion and activation of the latent large complex of TGF-beta-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "species_10511397", "map_id": "none", "name": "Large latent complex of TGFB1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "species_10511431", "map_id": "none", "name": "Dimeric TGFB1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10511399", "map_id": "none", "name": "Latent TGF-beta-1 is cleaved by furin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10511389", "map_id": "none", "name": "Pre-TGFB1 complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "reaction_10511464", "map_id": "none", "name": "Activated type I receptor phosphorylates SMAD2/3 directly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_171062", "compartment_display": "early endosome membrane" }, { "id": "species_10511461", "map_id": "none", "name": "TGFB1:p-TGFBR:ZFYVE9:SMAD2/3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_171062", "compartment_display": "early endosome membrane", "complex": "true" }, { "id": "H2KZI9", "map_id": "H2KZI9", "name": "aka-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000101", "map_id": "WBGene00000101", "name": "aka-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10511451", "map_id": "none", "name": "TGFB1:p-TGFBR:ZFYVE9:p-2S-SMAD2/3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_171062", "compartment_display": "early endosome membrane", "complex": "true" }, { "id": "reaction_10511419", "map_id": "none", "name": "Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10511404", "map_id": "P45897", "name": "sma-4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00004858", "map_id": "WBGene00004858", "name": "sma-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10511417", "map_id": "none", "name": "p-2S-SMAD2/3:SMAD4", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P45897", "map_id": "P45897", "name": "sma-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10511455", "map_id": "none", "name": "Phosphorylated SMAD2/3 dissociates from TGFBR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17941", "compartment_display": "early endosome" }, { "id": "species_10511453", "map_id": "none", "name": "TGFB1:p-TGFBR:ZFYVE9", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_171062", "compartment_display": "early endosome membrane", "complex": "true" }, { "id": "reaction_10511520", "map_id": "none", "name": "The SMAD2/3:SMAD4 complex transfers to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10511518", "map_id": "none", "name": "p-2S-SMAD2/3:SMAD4", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10543457", "map_id": "none", "name": "SMAD2/3:SMAD4 heterotrimer binds SP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10543453", "map_id": "Q9XW26", "name": "sptf-3", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00012735", "map_id": "WBGene00012735", "name": "sptf-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10543455", "map_id": "none", "name": "p-2S-SMAD2/3:SMAD4:SP1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9XW26", "map_id": "Q9XW26", "name": "sptf-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10542739", "map_id": "none", "name": "SMAD2/3:SMAD4 heterotrimer forms a complex with RBL1, E2F4/5 and DP1/2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10532108", "map_id": "none", "name": "RBL1:E2F4:TFDP1,TFDP2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "G5EF11", "map_id": "G5EF11", "name": "efl-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001161", "map_id": "WBGene00001161", "name": "efl-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q22703", "map_id": "Q22703", "name": "dpl-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001061", "map_id": "WBGene00001061", "name": "dpl-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10542737", "map_id": "none", "name": "p-SMAD2/3:SMAD4:RBL1:E2F4/5:DP1/2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10543448", "map_id": "none", "name": "Degradation of Ub-SMAD7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10543446", "map_id": "none", "name": "Ub-SMAD7", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10542699", "map_id": "none", "name": "WWTR1:SMAD translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10542170", "map_id": "none", "name": "WWTR1:p-2S-SMAD2/3:SMAD4", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10542697", "map_id": "none", "name": "WWTR1:p-2S-SMAD2/3:SMAD4", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10543404", "map_id": "none", "name": "Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10543397", "map_id": "none", "name": "p-T,2S-SMAD2/3:SMAD4", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10543401", "map_id": "none", "name": "CDK8:CCNC/ CDK9:CCNT", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "P90866", "map_id": "P90866", "name": "cdk-8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000409", "map_id": "WBGene00000409", "name": "cdk-8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9TYP2", "map_id": "Q9TYP2", "name": "cic-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000506", "map_id": "WBGene00000506", "name": "cic-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10542172", "map_id": "none", "name": "WWTR1 binds SMAD2/3:SMAD4 heterotrimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10541983", "map_id": "Q19404", "name": "yap-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10551215", "map_id": "none", "name": "ATP1B4 binds SNW1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13231", "compartment_display": "nuclear envelope" }, { "id": "species_10551211", "map_id": "none", "name": "Homologues of ATP1B4", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_13231", "compartment_display": "nuclear envelope", "complex": "true" }, { "id": "Q93235", "map_id": "Q93235", "name": "nkb-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007646", "map_id": "WBGene00007646", "name": "nkb-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XUG9", "map_id": "Q9XUG9", "name": "nkb-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008074", "map_id": "WBGene00008074", "name": "nkb-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XUY5", "map_id": "Q9XUY5", "name": "nkb-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010117", "map_id": "WBGene00010117", "name": "nkb-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10551213", "map_id": "none", "name": "ATP1B4:SNW1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10543472", "map_id": "none", "name": "Dephosphorylated SMAD2/3 translocates to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10516318", "map_id": "Q21733", "name": "daf-8", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10543410", "map_id": "none", "name": "NEDD4L binds phosphorylated linker region of SMAD2/3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10543406", "map_id": "A0A061ACQ8", "name": "NEDD4L", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10543408", "map_id": "none", "name": "p-T-2S-SMAD2/3:SMAD4:NEDDL4", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10516323", "map_id": "none", "name": "PPM1A dephosphorylates nuclear SMAD2/3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10516316", "map_id": "none", "name": "p-2S-SMAD2/3:SMAD4:PPM1A", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10516314", "map_id": "Q19775", "name": "ppm-1.A", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10511512", "map_id": "P45897", "name": "sma-4", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10543414", "map_id": "none", "name": "NEDD4L ubiquitinates SMAD2/3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10543412", "map_id": "none", "name": "Ub-p-T-2S-SMAD2/3:SMAD4", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10543416", "map_id": "none", "name": "Degradation of SMAD2/3:SMAD4 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10528057", "map_id": "none", "name": "Ubiquitinated SMAD4 translocates from the nucleus to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10528053", "map_id": "none", "name": "Ub-SMAD4", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10528055", "map_id": "none", "name": "Ub-SMAD4", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10511547", "map_id": "none", "name": "Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10511544", "map_id": "none", "name": "Nuclear ubiquitin ligase", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10543470", "map_id": "none", "name": "PPM1A protein phosphatase binds phosphorylated SMAD2/3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10548818", "map_id": "none", "name": "Clathrin internalises EPH:EFN complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10548814", "map_id": "none", "name": "AP-2 Complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q22601", "map_id": "Q22601", "name": "apa-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000161", "map_id": "WBGene00000161", "name": "apa-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9N4F3", "map_id": "Q9N4F3", "name": "apb-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000160", "map_id": "WBGene00000160", "name": "apb-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P35603", "map_id": "P35603", "name": "dpy-23", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001082", "map_id": "WBGene00001082", "name": "dpy-23", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q19123", "map_id": "Q19123", "name": "aps-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000157", "map_id": "WBGene00000157", "name": "aps-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10512890", "map_id": "none", "name": "Clathrin", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10512936", "map_id": "P39055", "name": "dyn-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "WBGene00001130", "map_id": "WBGene00001130", "name": "dyn-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10548503", "map_id": "none", "name": "EPHBs:EFNBs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "O44516", "map_id": "O44516", "name": "phospho-efn-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001165", "map_id": "WBGene00001165", "name": "phospho-efn-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q19475", "map_id": "Q19475", "name": "phospho-efn-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001164", "map_id": "WBGene00001164", "name": "phospho-efn-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9U3M2", "map_id": "Q9U3M2", "name": "phospho-efn-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001163", "map_id": "WBGene00001163", "name": "phospho-efn-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EEE7", "map_id": "G5EEE7", "name": "phospho-vab-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006869", "map_id": "WBGene00006869", "name": "phospho-vab-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O61460", "map_id": "O61460", "name": "vab-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006868", "map_id": "WBGene00006868", "name": "vab-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10548802", "map_id": "none", "name": "f-actin", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10548816", "map_id": "none", "name": "EPHB:EFNB:F-actin:AP-2:Clathrrin:Dynamin", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "P39055", "map_id": "P39055", "name": "dyn-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10549028", "map_id": "none", "name": "EPHA binds TIAM1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10548777", "map_id": "none", "name": "EFNAs:p-EPHAs:SFKs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10516084", "map_id": "O01847", "name": "tiam-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10548779", "map_id": "none", "name": "EFNAs:p-EPHAs:SFKs:TIAM1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10548616", "map_id": "none", "name": "SFKs phosphorylate VAV2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10548611", "map_id": "none", "name": "EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:VAV2,VAV3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10548613", "map_id": "none", "name": "EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:p-VAV2,VAV3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10548857", "map_id": "none", "name": "MMP2,9 cleave EPHB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10548844", "map_id": "O61460", "name": "vab-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10548491", "map_id": "none", "name": "EFNBs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10548820", "map_id": "O61460", "name": "vab-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10548854", "map_id": "none", "name": "MMP2, MMP9", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10548842", "map_id": "none", "name": "gamma-secretase cleaves EPHB2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10548830", "map_id": "O61460", "name": "vab-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10548840", "map_id": "O61460", "name": "vab-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10548618", "map_id": "none", "name": "p-EPHs bind VAV2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10516077", "map_id": "Q45FX5", "name": "vav-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10548609", "map_id": "none", "name": "p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10548763", "map_id": "none", "name": "VAV exchanges GTP for GDP on RAC1, activating it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10520575", "map_id": "none", "name": "RAC1:GDP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10548782", "map_id": "none", "name": "TIAM1 exchanges GTP for GDP on RAC1, activating it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10572371", "map_id": "none", "name": "HEXB cleaves the terminal GalNAc from keratan sulfate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_2105012", "map_id": "CHEBI:63852", "name": "GlcNAc-Gal-GlcNAc(S)-Gal", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_2105010", "map_id": "CHEBI:63853", "name": "Gal-GlcNAc(S)-Gal", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_1605658", "map_id": "CHEBI:28037", "name": "GalNAc", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "reaction_10536644", "map_id": "none", "name": "HEXA cleaves the terminal GalNAc from keratan sulfate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "reaction_10536555", "map_id": "none", "name": "GLB1 hydrolyses a glycosaminoglycan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_2104997", "map_id": "CHEBI:63850", "name": "Gal-GlcNAc(S)-Gal-GlcNAc(S)-Gal", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_1605637", "map_id": "CHEBI:28061", "name": "Gal", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_2104995", "map_id": "CHEBI:63851", "name": "GlcNAc(S)-Gal-GlcNAc(S)-Gal", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_10536350", "map_id": "Q27526", "name": "bgal-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "WBGene00011832", "map_id": "WBGene00011832", "name": "bgal-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10542450", "map_id": "none", "name": "HS3ST1 sulfates GlcN at C3 in heparan sulfate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "species_10541552", "map_id": "none", "name": "HS(3)-PGs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "G5EGU4", "map_id": "G5EGU4", "name": "gpn-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001687", "map_id": "WBGene00001687", "name": "gpn-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q18530", "map_id": "Q18530", "name": "lon-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003056", "map_id": "WBGene00003056", "name": "lon-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34710", "map_id": "P34710", "name": "unc-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "unc-6", "map_id": "unc-6", "name": "unc-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10541588", "map_id": "none", "name": "HS(4)-PGs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "species_10542445", "map_id": "Q9TZK5", "name": "hst-3.1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "WBGene00002030", "map_id": "WBGene00002030", "name": "hst-3.1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10542484", "map_id": "none", "name": "HS3STs sulfate GlcN at C3 in heparan sulfate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10542481", "map_id": "none", "name": "HS3STs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "Q4TTA0", "map_id": "Q4TTA0", "name": "hst-3.2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00044303", "map_id": "WBGene00044303", "name": "hst-3.2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9TZK5", "map_id": "Q9TZK5", "name": "hst-3.1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10541429", "map_id": "none", "name": "NDST1-4 can sulfate a glucosamine residue in heparan to form heparan sulfate (HS)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10541379", "map_id": "none", "name": "Heparan(4)-PGs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "species_10541415", "map_id": "none", "name": "HS(1)-PGs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "species_10541420", "map_id": "Q966W3", "name": "hst-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "WBGene00002028", "map_id": "WBGene00002028", "name": "hst-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10542470", "map_id": "none", "name": "HS2ST1 sulfates IdoA at C2 in heparan sulfate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10541516", "map_id": "none", "name": "HS(2)-PGs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "species_10542467", "map_id": "O17645", "name": "hst-2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "WBGene00002029", "map_id": "WBGene00002029", "name": "hst-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10541468", "map_id": "none", "name": "NDST1-4 N-deacetylates GlcNAc residues in heparan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10541465", "map_id": "none", "name": "Heparan(3)-PGs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "reaction_10542462", "map_id": "none", "name": "HS6STs sulfate GlcN at C6 in heparan sulfate/heparin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10541624", "map_id": "none", "name": "HS(5)-PGs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "species_10541656", "map_id": "none", "name": "HS/HPIN-PGs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "species_10542455", "map_id": "G5EFN7", "name": "hst-6", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "WBGene00002031", "map_id": "WBGene00002031", "name": "hst-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10541822", "map_id": "none", "name": "Some HSPGs are secreted to the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "species_10541658", "map_id": "none", "name": "HSPGs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "species_10541820", "map_id": "none", "name": "HSPGs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10538116", "map_id": "none", "name": "B3GALT6 transfers Gal to the tetrasaccharide linker", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10538108", "map_id": "none", "name": "Gal-Xyl-proteins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "Q8IG72", "map_id": "Q8IG72", "name": "D2,4,4(S)3-CSPG4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016751", "map_id": "WBGene00016751", "name": "D2,4,4(S)3-CSPG4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_735682", "map_id": "CHEBI:18307", "name": "UDP-Gal", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10537964", "map_id": "none", "name": "Gal-Gal-Xyl-proteins", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "species_205687", "map_id": "CHEBI:17659", "name": "UDP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10538113", "map_id": "Q9N491", "name": "sqv-2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "WBGene00005020", "map_id": "WBGene00005020", "name": "sqv-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10537925", "map_id": "none", "name": "XYLTs transfer Xyl to core protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10537876", "map_id": "none", "name": "GAG core proteins", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "species_10537915", "map_id": "none", "name": "xylosyl-core proteins", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "species_10537920", "map_id": "Q965Q8", "name": "sqv-6", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "WBGene00005024", "map_id": "WBGene00005024", "name": "sqv-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10538069", "map_id": "none", "name": "B3GAT dimers transfer GlcA to tetrasaccharide linker", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_1889970", "map_id": "CHEBI:17200", "name": "UDP-GlcA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10538003", "map_id": "none", "name": "GlcA-Gal-Gal-Xyl-proteins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "species_10538066", "map_id": "none", "name": "B3GAT dimers", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "Q09363", "map_id": "Q09363", "name": "sqv-8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00005026", "map_id": "WBGene00005026", "name": "sqv-8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O17708", "map_id": "O17708", "name": "glct-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008293", "map_id": "WBGene00008293", "name": "glct-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XU73", "map_id": "Q9XU73", "name": "glct-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011781", "map_id": "WBGene00011781", "name": "glct-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O17751", "map_id": "O17751", "name": "glct-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008479", "map_id": "WBGene00008479", "name": "glct-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A0K3AUF6", "map_id": "A0A0K3AUF6", "name": "glct-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "W07G9.2b", "map_id": "W07G9.2b", "name": "glct-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O62113", "map_id": "O62113", "name": "glct-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008160", "map_id": "WBGene00008160", "name": "glct-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O02304", "map_id": "O02304", "name": "glct-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011650", "map_id": "WBGene00011650", "name": "glct-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10538124", "map_id": "none", "name": "B4GALT7 transfers Gal group to xylosyl-unit of the tetrasaccharide linker", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10538121", "map_id": "P34548", "name": "sqv-3", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "WBGene00005021", "map_id": "WBGene00005021", "name": "sqv-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10572364", "map_id": "none", "name": "B3GAT3 dimer transfers GlcA to tetrasaccharide linker", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10538064", "map_id": "none", "name": "B3GAT3:Mn2+ dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "reaction_10537394", "map_id": "none", "name": "NAGLU hydrolyses Heparan sulfate chain(4)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_2090069", "map_id": "CHEBI:63807", "name": "Heparan sulfate chain(4)", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_2090080", "map_id": "CHEBI:63808", "name": "Heparan sulfate chain(5)", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_10537391", "map_id": "Q9NAP6", "name": "NAGLU(59-743)", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "WBGene00010722", "map_id": "WBGene00010722", "name": "NAGLU(59-743)", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10542691", "map_id": "none", "name": "NAGLU hydrolyses heparan chain(2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_2090053", "map_id": "CHEBI:63645", "name": "Heparan chain(2)", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_2065212", "map_id": "CHEBI:63505", "name": "CS/HS precursor", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "reaction_10542693", "map_id": "none", "name": "GLB1 hydrolyses linker chain(2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_2090075", "map_id": "CHEBI:63503", "name": "linker chain(2)", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_2090063", "map_id": "CHEBI:15936", "name": "D-xylose", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "reaction_10541480", "map_id": "none", "name": "HS-GAGs translocate to the lysosome for degradation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10537360", "map_id": "none", "name": "HS/HPIN-PGs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10537017", "map_id": "none", "name": "HS/HPIN-PGs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "true" }, { "id": "reaction_10537435", "map_id": "none", "name": "GUSB tetramer hydrolyses CS/HS precursor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_427963", "map_id": "CHEBI:29991", "name": "L-Asp", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "reaction_10542856", "map_id": "none", "name": "Growing HA is extruded from the cell by ABCC5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_2142896", "map_id": "none", "name": "HA polymer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_2160848", "map_id": "none", "name": "HA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10534273", "map_id": "G5EE72", "name": "mrp-5", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "WBGene00003411", "map_id": "WBGene00003411", "name": "mrp-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10540904", "map_id": "none", "name": "DSPGs are secreted", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "species_10540902", "map_id": "none", "name": "DSPGs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "species_10540868", "map_id": "none", "name": "DSPGs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10537457", "map_id": "none", "name": "HYAL1 hydrolyses Chondroitin chains", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_2065257", "map_id": "none", "name": "Chondroitin chains", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "true" }, { "id": "CHEBI:63512", "map_id": "CHEBI:63512", "name": "CHEBI:63512", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:63513", "map_id": "CHEBI:63513", "name": "CHEBI:63513", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:63515", "map_id": "CHEBI:63515", "name": "CHEBI:63515", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_2065239", "map_id": "CHEBI:63511", "name": "Chondroitin chain", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "reaction_10536470", "map_id": "none", "name": "ARSB hydrolyses DS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_2065231", "map_id": "CHEBI:63519", "name": "ChEBI:63519 chain", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_1606845", "map_id": "CHEBI:16189", "name": "SO4(2-)", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_2065213", "map_id": "CHEBI:63517", "name": "ChEBI:63517 chain", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_10536467", "map_id": "none", "name": "ARSB:Ca2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "true" }, { "id": "A0A4V0IJ66", "map_id": "A0A4V0IJ66", "name": "sul-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006310", "map_id": "WBGene00006310", "name": "sul-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10542695", "map_id": "none", "name": "HEXA cleaves the terminal GalNAc from DS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_2065269", "map_id": "CHEBI:63516", "name": "ChEBI:63516 chain", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_2105025", "map_id": "CHEBI:63873", "name": "IdoA-GalNAc(4S)-GlcA-Gal-Gal-Xyl", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "reaction_10537447", "map_id": "none", "name": "ARSB hydrolyses C4S/C6S chains", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_2065251", "map_id": "none", "name": "C4S/C6S chains", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "true" }, { "id": "reaction_10540892", "map_id": "none", "name": "DSPG and CSPG translocate to the lysosome for degradation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10540876", "map_id": "none", "name": "CSPGs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10540890", "map_id": "none", "name": "DSPGs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "true" }, { "id": "species_10540884", "map_id": "none", "name": "CSPGs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "true" }, { "id": "reaction_10572367", "map_id": "none", "name": "HEXB cleaves the terminal GalNAc from DS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "reaction_10541472", "map_id": "none", "name": "CSPG is secreted", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "species_10541470", "map_id": "none", "name": "CSPGs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "reaction_10572304", "map_id": "none", "name": "CHSY1 transfers GlcA to chondroitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10538300", "map_id": "Q8IG72", "name": "chondroitin(1)-CSPG4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10538309", "map_id": "Q8IG72", "name": "chondroitin(2)-CSPG4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10572298", "map_id": "Q7Z1Z1", "name": "sqv-5", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "WBGene00005023", "map_id": "WBGene00005023", "name": "sqv-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10538324", "map_id": "none", "name": "CHPF,CHSY3 transfer GalNAc to chondroitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10538303", "map_id": "Q8IG72", "name": "chondroitin(3)-CSPG4", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10538321", "map_id": "none", "name": "CHPF,CHSY3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "P45895", "map_id": "P45895", "name": "mig-22", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003253", "map_id": "WBGene00003253", "name": "mig-22", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7Z1Z1", "map_id": "Q7Z1Z1", "name": "sqv-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10538329", "map_id": "none", "name": "CHPF,CHPF2,CHSY3 transfer GlcA to chondroitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "reaction_10572301", "map_id": "none", "name": "CHSY1 transfers GalNAc to chondroitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "reaction_10510178", "map_id": "none", "name": "TFAM binds to mitochondrial promoters", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10510174", "map_id": "Q94234", "name": "hmg-5", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "WBGene00001975", "map_id": "WBGene00001975", "name": "hmg-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_163305", "map_id": "none", "name": "mitochondrial DNA promoter", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10510176", "map_id": "none", "name": "TFAM:mitochondrial promoter complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q94234", "map_id": "Q94234", "name": "hmg-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10508532", "map_id": "none", "name": "PDPK1 binds PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10508528", "map_id": "Q9UA62", "name": "PDPK1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10508551", "map_id": "none", "name": "PDPK1 phosphorylates AKT2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10508521", "map_id": "none", "name": "AKT2:PIP3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10508548", "map_id": "none", "name": "p-T309,S474-AKT2:PIP3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10508523", "map_id": "none", "name": "AKT2 binds PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10508519", "map_id": "none", "name": "AKT2:THEM4,TRIB3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "G5EED4", "map_id": "G5EED4", "name": "nipi-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010700", "map_id": "WBGene00010700", "name": "nipi-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10508500", "map_id": "G5EED4", "name": "nipi-3", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10510068", "map_id": "none", "name": "p-S295-PDE3B hydrolyses cAMP to AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10510065", "map_id": "Q8I0P7", "name": "phospho-pde-3", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10508495", "map_id": "none", "name": "PI3K-containing complexes phosphorylate PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10513499", "map_id": "none", "name": "RhoA is activated by nucleotide exchange and inhibits axonal growth", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10513496", "map_id": "H2KYI7", "name": "cgef-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10522807", "map_id": "none", "name": "eNoSC deacetylates histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10522790", "map_id": "none", "name": "Chromatin with acetylated H3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_427523", "map_id": "CHEBI:57540", "name": "NAD+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_427497", "map_id": "CHEBI:17154", "name": "NAM", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_427498", "map_id": "CHEBI:76279", "name": "2'-O-acetyl-ADP-ribose", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10517072", "map_id": "none", "name": "Chromatin", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10522804", "map_id": "none", "name": "eNoSC", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q21921", "map_id": "Q21921", "name": "sir-2.1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004800", "map_id": "WBGene00004800", "name": "sir-2.1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O44410", "map_id": "O44410", "name": "RRP8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020296", "map_id": "WBGene00020296", "name": "RRP8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10522810", "map_id": "none", "name": "eNoSC dimethylates histone H3 at lysine-9", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10507005", "map_id": "none", "name": "Chromatin (H3K9me2)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10522776", "map_id": "none", "name": "MBD2 binds methylcytosine in chromatin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10522772", "map_id": "none", "name": "Chromatin with H3K9me2, 5mC", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10522770", "map_id": "G5ECR1", "name": "mbd-2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10522774", "map_id": "none", "name": "Chromatin (H3K9me2, 5mC):MBD2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10547602", "map_id": "none", "name": "Constitutive phosphorylation by GSK3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10547597", "map_id": "G5EFT5", "name": "hsf-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00002004", "map_id": "WBGene00002004", "name": "phospho-hsf-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10547600", "map_id": "G5EFT5", "name": "phospho-hsf-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10513574", "map_id": "none", "name": "Homologues of GSK3B", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10547682", "map_id": "none", "name": "DBC1 binds SIRT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10547678", "map_id": "A0A0S4XR43", "name": "phospho-ccar-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10522802", "map_id": "Q21921", "name": "sir-2.1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10547680", "map_id": "none", "name": "p-T454-DBC1:SIRT1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10551170", "map_id": "none", "name": "HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10551131", "map_id": "none", "name": "Hikeshi:HSP70s:ATP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "G5EC99", "map_id": "G5EC99", "name": "HSPA1A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009691", "map_id": "WBGene00009691", "name": "HSPA1A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5ECU5", "map_id": "G5ECU5", "name": "HSPA1A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O45246", "map_id": "O45246", "name": "hsp-70", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002026", "map_id": "WBGene00002026", "name": "hsp-70", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "K8ERU5", "map_id": "K8ERU5", "name": "Hikeshi", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018328", "map_id": "WBGene00018328", "name": "Hikeshi", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10551129", "map_id": "K8ERU5", "name": "Hikeshi", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10551155", "map_id": "none", "name": "HSP70s:ADP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10551167", "map_id": "none", "name": "DNAJB1,B6,C2,C7", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9TY07", "map_id": "Q9TY07", "name": "dnj-24", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001042", "map_id": "WBGene00001042", "name": "dnj-24", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q94216", "map_id": "Q94216", "name": "dnj-11", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001029", "map_id": "WBGene00001029", "name": "dnj-11", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10551203", "map_id": "none", "name": "HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10551073", "map_id": "none", "name": "HSP70s:ATP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10551194", "map_id": "none", "name": "HSP70s:ADP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10551200", "map_id": "none", "name": "DNAJB1,B6,C2,C7", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10551077", "map_id": "none", "name": "Hikeshi binds HSP70s:ATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10551014", "map_id": "K8ERU5", "name": "Hikeshi", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10551075", "map_id": "none", "name": "Hikeshi:HSP70s:ATP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10549720", "map_id": "none", "name": "MAPKAPK2 phosphorylates HSF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10549717", "map_id": "G5EFT5", "name": "phospho-hsf-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10512624", "map_id": "none", "name": "Homologues of MAPKAPK2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10551241", "map_id": "none", "name": "HSP110s exchange ATP for ADP on HSP70s:ADP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10551231", "map_id": "none", "name": "HSP70 NEFs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q05036", "map_id": "Q05036", "name": "hsp-110", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016250", "map_id": "WBGene00016250", "name": "hsp-110", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O44739", "map_id": "O44739", "name": "bag-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000236", "map_id": "WBGene00000236", "name": "bag-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O61980", "map_id": "O61980", "name": "unc-23", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006760", "map_id": "WBGene00006760", "name": "unc-23", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10551239", "map_id": "none", "name": "ST13 tetramer", "type": "inhibitor", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "G5EE04", "map_id": "G5EE04", "name": "hip-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011735", "map_id": "WBGene00011735", "name": "hip-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10547675", "map_id": "none", "name": "Constitutive phosphorylation by pERK1/2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10547673", "map_id": "G5EFT5", "name": "phospho-hsf-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10547692", "map_id": "none", "name": "DBC1 is phosphorylated by ATM/ART", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10547684", "map_id": "A0A0S4XR43", "name": "ccar-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10547689", "map_id": "Q22258", "name": "atl-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00000226", "map_id": "WBGene00000226", "name": "atl-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10549888", "map_id": "none", "name": "Dissociation of HSF1:HSP90 complex in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10549886", "map_id": "none", "name": "HSF1:HSP90:PTGES3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "G5EFT5", "map_id": "G5EFT5", "name": "phospho-hsf-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10549884", "map_id": "none", "name": "HSP90:HSP90", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10549878", "map_id": "Q23280", "name": "daf-41", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10549859", "map_id": "G5EFT5", "name": "hsf-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10547717", "map_id": "none", "name": "Trimerization of cytosolic HSF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10547664", "map_id": "none", "name": "HSF1 trimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10509904", "map_id": "P53013", "name": "eft-4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00001168", "map_id": "WBGene00001168", "name": "eft-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10549861", "map_id": "none", "name": "Trimerization of HSF1 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10547668", "map_id": "none", "name": "HSF1 trimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10547670", "map_id": "none", "name": "HSF1 trimer translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10551291", "map_id": "none", "name": "Dissociation of cytosolic HSF1:HSP90:HDAC6:PTGES3 upon sensing protein aggregates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5324631", "map_id": "none", "name": "Ub-protein aggregates", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10551286", "map_id": "none", "name": "HSF1:HSP90:HDAC6:VCP:PTGES3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10517708", "map_id": "Q23280", "name": "daf-41", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10551288", "map_id": "none", "name": "HDAC6:VCP:protein aggregates", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10547652", "map_id": "none", "name": "HSP90:HSP90", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10547709", "map_id": "none", "name": "Dissociation of cytosolic HSF1:HSP90 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10547707", "map_id": "none", "name": "HSF1:HSP90:PTGES3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10549857", "map_id": "none", "name": "Phosphorylation of HSF1 at Ser230 induces transactivation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10549835", "map_id": "none", "name": "p-S230-HSF1 trimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10549854", "map_id": "none", "name": "CaMKII", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "O62305", "map_id": "O62305", "name": "phospho-unc-43", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006779", "map_id": "WBGene00006779", "name": "phospho-unc-43", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10549842", "map_id": "none", "name": "HSF1-mediated gene expression", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10549772", "map_id": "none", "name": "HSF1 trimer:target gene", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10549830", "map_id": "none", "name": "Heat shock inducible proteins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9U3B7", "map_id": "Q9U3B7", "name": "hsb-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002002", "map_id": "WBGene00002002", "name": "hsb-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q20660", "map_id": "Q20660", "name": "hsp-17", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002021", "map_id": "WBGene00002021", "name": "hsp-17", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q19227", "map_id": "Q19227", "name": "CRYAB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00014233", "map_id": "WBGene00014233", "name": "CRYAB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P06581", "map_id": "P06581", "name": "hsp-16.41", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002018", "map_id": "WBGene00002018", "name": "hsp-16.41", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "B0M0L8", "map_id": "B0M0L8", "name": "hsp-43", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002024", "map_id": "WBGene00002024", "name": "hsp-43", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q19228", "map_id": "Q19228", "name": "CRYAB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P06582", "map_id": "P06582", "name": "hsp-16.2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002016", "map_id": "WBGene00002016", "name": "hsp-16.2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EF99", "map_id": "G5EF99", "name": "CRYAB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q20363", "map_id": "Q20363", "name": "sip-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004798", "map_id": "WBGene00004798", "name": "sip-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34696", "map_id": "P34696", "name": "hsp-16.1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002015", "map_id": "WBGene00002015", "name": "hsp-16.1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P02513", "map_id": "P02513", "name": "hsp-16.48", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002019", "map_id": "WBGene00002019", "name": "hsp-16.48", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10549840", "map_id": "none", "name": "p-S326-HSF1 trimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10549876", "map_id": "none", "name": "Phosphorylation of HSF1 at Ser326 induces transactivation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10549873", "map_id": "none", "name": "mTORC1 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10547705", "map_id": "none", "name": "HSBP1 binds HSF1 trimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10547701", "map_id": "none", "name": "HSBP1 hexamer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10547703", "map_id": "none", "name": "HSBP1:HSF1 trimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10551274", "map_id": "none", "name": "HSP90:FKBP4:PTGES3 binds HSF1 trimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10551270", "map_id": "none", "name": "HSP90:FKBP4:PTGES3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "O45418", "map_id": "O45418", "name": "fkb-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001431", "map_id": "WBGene00001431", "name": "fkb-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10551272", "map_id": "none", "name": "HSF1 trimer:HSP90:FKBP4:PTGES3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10535090", "map_id": "none", "name": "PA is converted to CDP-DAG by CDS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane" }, { "id": "species_1524101", "map_id": "CHEBI:16337", "name": "PA", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_110577", "map_id": "CHEBI:17677", "name": "CTP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_1524064", "map_id": "CHEBI:17962", "name": "CDP-DAG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "species_10535087", "map_id": "P53439", "name": "cdgs-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "WBGene00016384", "map_id": "WBGene00016384", "name": "cdgs-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10535537", "map_id": "none", "name": "Fibronectin degradation by MMP1, 3, 7, 12, 13, 19, CTSS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10535515", "map_id": "none", "name": "Cleaved fibronectin matrix", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10535534", "map_id": "none", "name": "MMP1, 3, 7, 12, 13, 19, CTSS", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "O45734", "map_id": "O45734", "name": "cpl-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000776", "map_id": "WBGene00000776", "name": "cpl-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q23030", "map_id": "Q23030", "name": "CTSL1(114-288)", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019986", "map_id": "WBGene00019986", "name": "CTSL1(114-288)", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q93512", "map_id": "Q93512", "name": "CTSL1(114-288)", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10536417", "map_id": "none", "name": "MT-MMPs are sorted to the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "species_10536012", "map_id": "none", "name": "MT-MMPs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "species_10536415", "map_id": "none", "name": "MT-MMPs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10536167", "map_id": "none", "name": "Autocatalytic activation of MMP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10535663", "map_id": "none", "name": "Homologues of MMP3(55-477)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10536164", "map_id": "none", "name": "Homologues of MMP3(55-99)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10536136", "map_id": "none", "name": "Activation of MMP9 intermediate form by MMPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10535755", "map_id": "none", "name": "Homologues of MMP9(60-707)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10536134", "map_id": "none", "name": "Homologues of MMP9(60-106)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10534192", "map_id": "none", "name": "Homologues of MMP9(107-707)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10535771", "map_id": "none", "name": "MMP1 (2, 3, 7, 10, 13)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10535593", "map_id": "none", "name": "Full activation of MMP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10535588", "map_id": "none", "name": "Homologues of MMP1(84-469)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10534120", "map_id": "none", "name": "Homologues of MMP1(100-469)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10535590", "map_id": "none", "name": "MMP2,3,7,10,11", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10536014", "map_id": "none", "name": "Activation of MT-MMPs by FURIN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "species_10535950", "map_id": "none", "name": "proMT-MMPs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "reaction_10536047", "map_id": "none", "name": "Activation of proMMP11 by FURIN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "species_10536045", "map_id": "none", "name": "Homologues of MMP11(32-488)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "species_10534227", "map_id": "none", "name": "Homologues of MMP11", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10536244", "map_id": "none", "name": "Autocatalytic activation of proMMP13", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10536197", "map_id": "none", "name": "MMP13 intermediate forms", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10534136", "map_id": "none", "name": "Homologues of MMP13", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10536241", "map_id": "none", "name": "MMP13 intermediate form fragments", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10535571", "map_id": "Q19368", "name": "col-128", "type": "inhibitor", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "WBGene00000702", "map_id": "WBGene00000702", "name": "col-128", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10535573", "map_id": "none", "name": "Autocatalytic activation of proMMP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10535551", "map_id": "none", "name": "Homologues of MMP2(67-660)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10535565", "map_id": "none", "name": "Homologues of MMP2(67-109)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10534150", "map_id": "none", "name": "Homologues of MMP2(110-660)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10536277", "map_id": "none", "name": "Initial activation of proMMP13 by MMP14 (MT1-MMP)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10536061", "map_id": "none", "name": "Homologues of MMP13(20-471)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10536181", "map_id": "none", "name": "Homologues of MMP13(55-471)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10536258", "map_id": "none", "name": "Homologues of MMP13(20-54)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10536274", "map_id": "none", "name": "MMP14 (16)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10536120", "map_id": "none", "name": "Initial activation of proMMP2 by MMP1, 7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10536103", "map_id": "none", "name": "Homologues of MMP2(30-660)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10536117", "map_id": "none", "name": "Homologues of MMP2(30-66)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10536312", "map_id": "none", "name": "Initial activation of proMMP13 by MMP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10536291", "map_id": "none", "name": "Homologues of MMP13(20-76)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10536195", "map_id": "none", "name": "Homologues of MMP13(77-471)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10536309", "map_id": "none", "name": "MMP3, CTSK, CTSL2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10535774", "map_id": "none", "name": "Initial activation of proMMP9 by MMPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10535741", "map_id": "none", "name": "Homologues of MMP9(20-707)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10535769", "map_id": "none", "name": "Homologues of MMP9(20-59)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10536031", "map_id": "none", "name": "Autocatalytic activation of MMP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10535621", "map_id": "none", "name": "Homologues of MMP1(54-469)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10536028", "map_id": "none", "name": "Homologues of MMP1(54-83)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10534261", "map_id": "none", "name": "MMP1,3,13 (2, 7-12, 19) binding by Alpha-2 macroglubulin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10534199", "map_id": "none", "name": "A2M tetramer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "K8F7Z5", "map_id": "K8F7Z5", "name": "C3a-desArg", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008735", "map_id": "WBGene00008735", "name": "C3a-desArg", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7YTU0", "map_id": "Q7YTU0", "name": "tep-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013969", "map_id": "WBGene00013969", "name": "tep-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10534257", "map_id": "none", "name": "MMP1, 3, 13, (2, 7-12, 19)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10534259", "map_id": "none", "name": "Alpha 2-macroglobulin:MMP1, 3, 13, (2, 7-12, 19)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10568695", "map_id": "none", "name": "MMP13 cleaves OPTC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10568612", "map_id": "A0A4V0IJI7", "name": "lron-7", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "WBGene00019351", "map_id": "WBGene00019351", "name": "lron-7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10568618", "map_id": "A0A4V0IJI7", "name": "lron-7", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10568692", "map_id": "A0A4V0IJI7", "name": "lron-7", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10544776", "map_id": "none", "name": "Fibronectin degradation by MMP14, TMPRSS6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10534376", "map_id": "none", "name": "Homologues of MMP14", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10548232", "map_id": "none", "name": "Fibronectin degradation by ADAM8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10548207", "map_id": "none", "name": "Cleaved fibronectin matrix Ala(271)/Val(272)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10548229", "map_id": "none", "name": "Homologues of ADAM8", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q19844", "map_id": "Q19844", "name": "ADAM8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00270320", "map_id": "WBGene00270320", "name": "ADAM8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A1D3PCM0", "map_id": "A0A1D3PCM0", "name": "ADAM8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EDW5", "map_id": "G5EDW5", "name": "adm-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000074", "map_id": "WBGene00000074", "name": "adm-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EFD5", "map_id": "G5EFD5", "name": "unc-71", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006804", "map_id": "WBGene00006804", "name": "unc-71", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10535392", "map_id": "none", "name": "Collagen type V degradation by MMP2,9,10", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10519175", "map_id": "none", "name": "Collagen V", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "O76368", "map_id": "O76368", "name": "col-99", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000674", "map_id": "WBGene00000674", "name": "col-99", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q09457", "map_id": "Q09457", "name": "bli-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000251", "map_id": "WBGene00000251", "name": "bli-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9N4U2", "map_id": "Q9N4U2", "name": "col-71", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000647", "map_id": "WBGene00000647", "name": "col-71", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P17140", "map_id": "P17140", "name": "let-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002280", "map_id": "WBGene00002280", "name": "let-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O17641", "map_id": "O17641", "name": "col-178", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000751", "map_id": "WBGene00000751", "name": "col-178", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9N3X9", "map_id": "Q9N3X9", "name": "col-115", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000689", "map_id": "WBGene00000689", "name": "col-115", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10535387", "map_id": "none", "name": "Cleaved collagen type V fibril", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10535389", "map_id": "none", "name": "MMP2,9,10", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10543302", "map_id": "none", "name": "Collagen type XVIII endostatin release", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10543225", "map_id": "none", "name": "Collagen type XVIII multimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "Q19368", "map_id": "Q19368", "name": "col-128", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10543255", "map_id": "Q19368", "name": "col-128", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10543253", "map_id": "none", "name": "Cleaved collagen type XVIII multimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10543299", "map_id": "none", "name": "Endostatin-releasing proteases", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "P43510", "map_id": "P43510", "name": "cpr-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000786", "map_id": "WBGene00000786", "name": "cpr-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10535495", "map_id": "none", "name": "Collagen type VIII degradation by MMP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10535492", "map_id": "none", "name": "Collagen type VIII fibril", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10533894", "map_id": "none", "name": "Cleaved collagen type VIII fibril", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10544552", "map_id": "none", "name": "Endostatin degradation by cathepsins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10544549", "map_id": "none", "name": "Endostatin-degrading cathepsins", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "Q21966", "map_id": "Q21966", "name": "asp-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000217", "map_id": "WBGene00000217", "name": "asp-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10557611", "map_id": "none", "name": "PXLP-K278-PHYKPL tetramer hydrolyses 5PHL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_5696409", "map_id": "CHEBI:16752", "name": "5PHL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_5693978", "map_id": "CHEBI:16134", "name": "NH3", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_113556", "map_id": "CHEBI:17917", "name": "2AMAS", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10557608", "map_id": "none", "name": "PXLP-K278-PHYKPL tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "P91408", "map_id": "P91408", "name": "eppl-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020139", "map_id": "WBGene00020139", "name": "eppl-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10534379", "map_id": "none", "name": "Collagen type III degradation by MMP14", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10518945", "map_id": "none", "name": "Collagen type III fibril", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10533696", "map_id": "none", "name": "Cleaved collagen type III fibril", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10534384", "map_id": "none", "name": "Collagen type III degradation by MMP1,8,9,13", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10534381", "map_id": "none", "name": "MMP1,8,9,13", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10543312", "map_id": "none", "name": "Collagen type XIX degradation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10542657", "map_id": "none", "name": "Collagen type XIX", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10544561", "map_id": "none", "name": "Collagen type III degradation by MMP15", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10536395", "map_id": "none", "name": "Homologues of MMP15", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10544563", "map_id": "none", "name": "Collagen type II degradation by MMP15", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10517286", "map_id": "none", "name": "Collagen type II fibril", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10533498", "map_id": "none", "name": "Cleaved collagen type II fibril", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10544565", "map_id": "none", "name": "Collagen type I degradation by MMP15", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10509625", "map_id": "none", "name": "Collagen type I fibril", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10533300", "map_id": "none", "name": "Cleaved collagen type I fibril", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10534197", "map_id": "none", "name": "Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10534088", "map_id": "none", "name": "Cleaved collagen fibrils", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10534194", "map_id": "none", "name": "MMP1-3, 7-9, 12, 13", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10534266", "map_id": "none", "name": "Collagen type I degradation by MMP1,2,8,13, PRSS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10534263", "map_id": "none", "name": "MMP1,2,8,13, PRSS2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10534362", "map_id": "none", "name": "Collagen type II degradation by MMP1,3,8,13,PRSS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10534359", "map_id": "none", "name": "MMP1,3,8,13, PRSS2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10543197", "map_id": "none", "name": "Collagen type XIII ectodomain shedding", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10542932", "map_id": "none", "name": "Collagen type XIII", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10543195", "map_id": "none", "name": "Collagen alpha-1(XIII) ectodomains", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10543121", "map_id": "none", "name": "Cleaved collagen type XIII", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10548284", "map_id": "none", "name": "Laminin-322 degradation by MMP14", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10517354", "map_id": "none", "name": "Laminin-332", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "O44565", "map_id": "O44565", "name": "lam-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002247", "map_id": "WBGene00002247", "name": "lam-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q18823", "map_id": "Q18823", "name": "phospho-lam-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016913", "map_id": "WBGene00016913", "name": "phospho-lam-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q19981", "map_id": "Q19981", "name": "tag-53", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006432", "map_id": "WBGene00006432", "name": "tag-53", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EG68", "map_id": "G5EG68", "name": "agr-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018304", "map_id": "WBGene00018304", "name": "agr-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q06561", "map_id": "Q06561", "name": "unc-52", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006787", "map_id": "WBGene00006787", "name": "unc-52", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5ECE3", "map_id": "G5ECE3", "name": "lam-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002248", "map_id": "WBGene00002248", "name": "lam-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q21313", "map_id": "Q21313", "name": "epi-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001328", "map_id": "WBGene00001328", "name": "epi-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10548282", "map_id": "none", "name": "Cleaved laminin-332", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10568621", "map_id": "none", "name": "MMP2 cleaves OPTC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10568616", "map_id": "A0A4V0IJI7", "name": "lron-7", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10568614", "map_id": "A0A4V0IJI7", "name": "lron-7", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10511937", "map_id": "none", "name": "Loading of claspin onto DNA during replication origin firing", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10502234", "map_id": "none", "name": "CDK:DDK:MCM10:active pre-replicative complex:CDC45", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q7JMR0", "map_id": "Q7JMR0", "name": "evl-18", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009372", "map_id": "WBGene00009372", "name": "evl-18", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O01493", "map_id": "O01493", "name": "cdc-7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016421", "map_id": "WBGene00016421", "name": "cdc-7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9U2C2", "map_id": "Q9U2C2", "name": "mcm-10", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012935", "map_id": "WBGene00012935", "name": "mcm-10", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10511927", "map_id": "O17838", "name": "clsp-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00009127", "map_id": "WBGene00009127", "name": "clsp-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10511929", "map_id": "none", "name": "Cdc45:CDK:DDK:Mcm10:claspin:pre-replicative complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "O17838", "map_id": "O17838", "name": "clsp-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10511922", "map_id": "none", "name": "Recruitment of the Rad9-Hus1-Rad1 complex to DNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10511917", "map_id": "none", "name": "Rad17-RFC complex bound to DNA", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "G5EGG2", "map_id": "G5EGG2", "name": "hpr-17", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001998", "map_id": "WBGene00001998", "name": "hpr-17", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10511913", "map_id": "none", "name": "RAD9:HUS1:RAD1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "G5EFI9", "map_id": "G5EFI9", "name": "hus-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002042", "map_id": "WBGene00002042", "name": "hus-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EC44", "map_id": "G5EC44", "name": "mrt-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003417", "map_id": "WBGene00003417", "name": "mrt-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q95Q27", "map_id": "Q95Q27", "name": "hpr-9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001997", "map_id": "WBGene00001997", "name": "hpr-9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10511919", "map_id": "none", "name": "Rad9-Hus1-Rad1 bound to DNA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10502791", "map_id": "none", "name": "Phosphorylation of Cdc25A at Ser-123 by Chk1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10502781", "map_id": "Q21762", "name": "phospho-cdc-25.4", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10502788", "map_id": "Q9N3Z3", "name": "phospho-chk-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00000498", "map_id": "WBGene00000498", "name": "phospho-chk-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10507017", "map_id": "none", "name": "Phosphorylation of Cdc25C at Ser 216 by Chk1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10507012", "map_id": "Q21762", "name": "cdc-25.4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10507015", "map_id": "Q21762", "name": "phospho-cdc-25.4", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10542996", "map_id": "none", "name": "Arachidonic acid is epoxidated to 5,6-EET by CYP(4)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_2161753", "map_id": "none", "name": "8,9/11,12/14,15-EET", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:34130", "map_id": "CHEBI:34130", "name": "CHEBI:34130", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:34490", "map_id": "CHEBI:34490", "name": "CHEBI:34490", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:34157", "map_id": "CHEBI:34157", "name": "CHEBI:34157", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10519552", "map_id": "none", "name": "Release of CSK from SRC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10519544", "map_id": "none", "name": "Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "G5EGK1", "map_id": "G5EGK1", "name": "tln-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006771", "map_id": "WBGene00006771", "name": "tln-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34400", "map_id": "P34400", "name": "mig-10", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003243", "map_id": "WBGene00003243", "name": "mig-10", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10518223", "map_id": "G5ECJ6", "name": "csk-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10519550", "map_id": "none", "name": "Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10518244", "map_id": "none", "name": "Recruitment of GRB2 to p-PTK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10518240", "map_id": "none", "name": "Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q95YD4", "map_id": "Q95YD4", "name": "phospho-kin-32", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002213", "map_id": "WBGene00002213", "name": "phospho-kin-32", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10518242", "map_id": "none", "name": "GRB2 bound to pPTK2 in Focal adhesion", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10518263", "map_id": "none", "name": "Interaction of SOS with GRB2 bound to FADK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10506876", "map_id": "Q9N5D3", "name": "sos-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10518261", "map_id": "none", "name": "GRB2:SOS:p-PTK2:Focal adhesion", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10518210", "map_id": "none", "name": "Autophosphorylation of PTK2 at Y397", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10518200", "map_id": "none", "name": "Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10518207", "map_id": "none", "name": "Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10518277", "map_id": "none", "name": "Activation of Rap1 by cytosolic GEFs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10518274", "map_id": "none", "name": "CalDAG-GEFs:DAG:Ca2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q19770", "map_id": "Q19770", "name": "phospho-rgef-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009100", "map_id": "WBGene00009100", "name": "phospho-rgef-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10518246", "map_id": "none", "name": "Activation of Talin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10518171", "map_id": "none", "name": "Rap1-GTP:PIP2:RIAM", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10518194", "map_id": "G5EGK1", "name": "tln-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10518196", "map_id": "none", "name": "Talin:RIAM complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10523400", "map_id": "none", "name": "SYK binds to integrin alphaIIb beta3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10516474", "map_id": "Q18462", "name": "SYK", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10518198", "map_id": "none", "name": "Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10523398", "map_id": "none", "name": "Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10518255", "map_id": "none", "name": "Phosphorylation of pPTK2 by SRC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10523408", "map_id": "none", "name": "SYK activation by SRC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10523405", "map_id": "none", "name": "Talin:RIAM:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC):p(Y)-SYK", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10529458", "map_id": "none", "name": "Activation of Rap1 by membrane-associated GEFs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10520078", "map_id": "P34578", "name": "epac-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "WBGene00004255", "map_id": "WBGene00004255", "name": "epac-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10518259", "map_id": "none", "name": "Interaction of integrin alphaIIb beta3 with Fibrinogen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10515311", "map_id": "none", "name": "Homologues of FN1(32-2386)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10518229", "map_id": "none", "name": "Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_377604", "map_id": "none", "name": "Integrin binding divalent cations", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10518257", "map_id": "none", "name": "Focal complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10519542", "map_id": "none", "name": "Autophosphorylation of SRC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10519539", "map_id": "none", "name": "Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10518231", "map_id": "none", "name": "Integrin alphaIIb beta3 activation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10518227", "map_id": "none", "name": "Integrin alphaIIb beta3:p-Y530-SRC:CSK", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10519546", "map_id": "none", "name": "Clustering of Integrin alphaIIb beta3 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10518202", "map_id": "none", "name": "Translocation of PTK2 to Focal complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10514906", "map_id": "Q95YD4", "name": "kin-32", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10524570", "map_id": "none", "name": "SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10524564", "map_id": "none", "name": "Integrin alphaIIb beta 3:p(Y530)-SRC:CSK:Talin:RIAM complex:SHC", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10524568", "map_id": "none", "name": "Integrin alpha IIb beta 3:p-Y530-SRC:CSK:Talin:RIAM complex:p-Y427-SHC", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10518173", "map_id": "none", "name": "Translocation of RIAM to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10518169", "map_id": "P34400", "name": "mig-10", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10503824", "map_id": "none", "name": "TDO tetramer dioxygenates L-Trp to NFK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29500", "map_id": "CHEBI:57912", "name": "L-Trp", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_33179", "map_id": "CHEBI:18377", "name": "NFK", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10503821", "map_id": "none", "name": "TDO2 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q09474", "map_id": "Q09474", "name": "tdo-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016201", "map_id": "WBGene00016201", "name": "tdo-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10503843", "map_id": "none", "name": "3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_34351", "map_id": "CHEBI:17380", "name": "3HKYN", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_29432", "map_id": "CHEBI:57972", "name": "L-Ala", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_30487", "map_id": "CHEBI:15793", "name": "3HAA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10503840", "map_id": "none", "name": "KYNU dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q18026", "map_id": "Q18026", "name": "flu-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00015802", "map_id": "WBGene00015802", "name": "flu-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10503832", "map_id": "none", "name": "kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29970", "map_id": "CHEBI:16946", "name": "L-KYN", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10503829", "map_id": "Q21795", "name": "kmo-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00011089", "map_id": "WBGene00011089", "name": "kmo-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10528412", "map_id": "none", "name": "PXLP-KYAT1 dimer transaminates L-KYN to AP-DOBu", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_893615", "map_id": "CHEBI:17442", "name": "AP-DOBu", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10528406", "map_id": "none", "name": "PXLP-KYAT1 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9XX97", "map_id": "Q9XX97", "name": "nkat-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009232", "map_id": "WBGene00009232", "name": "nkat-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8MP09", "map_id": "Q8MP09", "name": "nkat-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010984", "map_id": "WBGene00010984", "name": "nkat-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_29502", "map_id": "CHEBI:58095", "name": "L-Phe", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_8939576", "map_id": "none", "name": "I3LACT, I3PROPA", "type": "inhibitor", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:55528", "map_id": "CHEBI:55528", "name": "CHEBI:55528", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:43580", "map_id": "CHEBI:43580", "name": "CHEBI:43580", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10503853", "map_id": "none", "name": "3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_36027", "map_id": "CHEBI:29044", "name": "ACS", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10503850", "map_id": "none", "name": "HAAO", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q19341", "map_id": "Q19341", "name": "haao-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010595", "map_id": "WBGene00010595", "name": "haao-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10566750", "map_id": "none", "name": "SLC36A4 transports L-Trp from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_352006", "map_id": "CHEBI:57912", "name": "L-Trp", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10566747", "map_id": "none", "name": "Homologues of SLC36A4", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "O45936", "map_id": "O45936", "name": "slc-36.1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012804", "map_id": "WBGene00012804", "name": "slc-36.1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O62286", "map_id": "O62286", "name": "slc-36.4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010421", "map_id": "WBGene00010421", "name": "slc-36.4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34479", "map_id": "P34479", "name": "skat-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010307", "map_id": "WBGene00010307", "name": "skat-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q18595", "map_id": "Q18595", "name": "slc-36.5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016628", "map_id": "WBGene00016628", "name": "slc-36.5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XX44", "map_id": "Q9XX44", "name": "slc-36.3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012629", "map_id": "WBGene00012629", "name": "slc-36.3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G4SQY7", "map_id": "G4SQY7", "name": "slc-36.2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020837", "map_id": "WBGene00020837", "name": "slc-36.2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10542434", "map_id": "none", "name": "Hydration of delta2-tetracosaheptaenoyl-CoA to 3-hydroxy tetracosahexaenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_2066767", "map_id": "CHEBI:65139", "name": "delta2-THA-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_2066766", "map_id": "CHEBI:65130", "name": "1-3-hydroxy-THA-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "reaction_10542291", "map_id": "none", "name": "Desaturation of alpha-linoleoyl-CoA to Stearidonoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_113534", "map_id": "CHEBI:15379", "name": "O2", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_194697", "map_id": "CHEBI:57945", "name": "NADH", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_2046062", "map_id": "CHEBI:51985", "name": "ALA-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_194653", "map_id": "CHEBI:57540", "name": "NAD+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_2046052", "map_id": "CHEBI:63545", "name": "SDA-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10542288", "map_id": "Q23221", "name": "fat-3", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "WBGene00001395", "map_id": "WBGene00001395", "name": "fat-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10542308", "map_id": "none", "name": "Desaturation of eicosatetraenoyl-CoA to eicosapentaenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_2046051", "map_id": "CHEBI:63542", "name": "ETA-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_2046059", "map_id": "CHEBI:63539", "name": "EPA-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10542305", "map_id": "none", "name": "Homologues of FADS1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "G5EG11", "map_id": "G5EG11", "name": "fat-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001396", "map_id": "WBGene00001396", "name": "fat-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q23221", "map_id": "Q23221", "name": "fat-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10542436", "map_id": "none", "name": "Conversion of DHA-CoA to docosahexaenoic acid (DHA)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_2066765", "map_id": "CHEBI:65132", "name": "DHA-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "reaction_10542294", "map_id": "none", "name": "Translocation of tetracosahexaenoyl-CoA to peroxisomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_2046054", "map_id": "CHEBI:63540", "name": "THA-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_211579", "map_id": "CHEBI:30616", "name": "ATP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_211606", "map_id": "CHEBI:456216", "name": "ADP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_2046047", "map_id": "CHEBI:63540", "name": "THA-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_10520379", "map_id": "O45730", "name": "pmp-4", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane", "complex": "false" }, { "id": "WBGene00004061", "map_id": "WBGene00004061", "name": "pmp-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10542438", "map_id": "none", "name": "Dehydrogenation of 3-hydroxy tetracosahexaenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_2066762", "map_id": "CHEBI:65131", "name": "1-3-oxo-THA-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "reaction_10542296", "map_id": "none", "name": "Elongation of stearidonoyl-CoA to eicosatetraenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_2046066", "map_id": "CHEBI:15531", "name": "Malonyl-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_113601", "map_id": "CHEBI:16474", "name": "NADPH", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_113564", "map_id": "CHEBI:18009", "name": "NADP+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_162743", "map_id": "CHEBI:15346", "name": "CoA-SH", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_159751", "map_id": "CHEBI:16526", "name": "CO2", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "reaction_10542440", "map_id": "none", "name": "Oxidation of tetracosapentaenoyl-CoA to delta2-tetracosaheptaenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_10520766", "map_id": "none", "name": "ACOX1 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "true" }, { "id": "reaction_10567994", "map_id": "none", "name": "26S proteasome degrades Ub-NFE2L2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10567992", "map_id": "none", "name": "Ub-NFE2L2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P34707", "map_id": "P34707", "name": "phospho-skn-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004804", "map_id": "WBGene00004804", "name": "phospho-skn-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10573338", "map_id": "none", "name": "NFE2L2 inducers bind to KEAP1:CUL3:RBX1:NFE2L2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10567990", "map_id": "none", "name": "KEAP1:CUL3:RBX1:NFE2L2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_9714134", "map_id": "none", "name": "NFE2L2 inducers", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10573336", "map_id": "none", "name": "NFE2L2 inducers:KEAP1:CUL3:RBX1:NFE2L2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10567982", "map_id": "none", "name": "NFE2L2 translocates from cytosol to nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10567974", "map_id": "none", "name": "p-NFE2L2", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10567980", "map_id": "none", "name": "p-NFE2L2", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10553087", "map_id": "none", "name": "SYK phosphorylates PLCG2 in p-6Y-SYK:p-Y65,Y76-FCER1G:PLCG2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10553084", "map_id": "none", "name": "pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:p-6Y-SYK:PLCG2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10553082", "map_id": "none", "name": "pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:p-6Y-SYK:p-Y753,Y759-PLCG2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10565886", "map_id": "none", "name": "CLEC10A binds Tn-MUC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10565882", "map_id": "none", "name": "Tn antigens", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9U2D6", "map_id": "Q9U2D6", "name": "cnp-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012901", "map_id": "WBGene00012901", "name": "cnp-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34501", "map_id": "P34501", "name": "Core 8 (MUC4)", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010540", "map_id": "WBGene00010540", "name": "Core 8 (MUC4)", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10565876", "map_id": "none", "name": "Homologues of CLEC10A", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9N4W4", "map_id": "Q9N4W4", "name": "clec-205", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021602", "map_id": "WBGene00021602", "name": "clec-205", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9N4W5", "map_id": "Q9N4W5", "name": "clec-204", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021603", "map_id": "WBGene00021603", "name": "clec-204", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O18076", "map_id": "O18076", "name": "clec-47", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011668", "map_id": "WBGene00011668", "name": "clec-47", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O44871", "map_id": "O44871", "name": "clec-150", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019914", "map_id": "WBGene00019914", "name": "clec-150", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P91214", "map_id": "P91214", "name": "clec-45", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017199", "map_id": "WBGene00017199", "name": "clec-45", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q21146", "map_id": "Q21146", "name": "clec-149", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019328", "map_id": "WBGene00019328", "name": "clec-149", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10565884", "map_id": "none", "name": "CLEC10A:Tn antigens", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10531875", "map_id": "none", "name": "FUT8 transfers fucosyl group from GDP-Fuc to GlcNAc of NGP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_975910", "map_id": "CHEBI:59520", "name": "NGP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_205689", "map_id": "CHEBI:17552", "name": "GDP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_1028779", "map_id": "none", "name": "NGP:1,6-GlcNAc", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10531872", "map_id": "G5EFE7", "name": "fut-8", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "WBGene00001508", "map_id": "WBGene00001508", "name": "fut-8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10530580", "map_id": "none", "name": "Trimming of mannoses on the alpha1,6 arm by MAN2A1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_964837", "map_id": "CHEBI:60625", "name": "(GlcNAc)3 (Man)5 (Asn)1", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_964752", "map_id": "CHEBI:4208", "name": "Man", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_975819", "map_id": "CHEBI:60615", "name": "(GlcNAc)3 (Man)3 (Asn)1", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10530577", "map_id": "none", "name": "MAN2A1:Zn2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "Q2PJ74", "map_id": "Q2PJ74", "name": "aman-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010284", "map_id": "WBGene00010284", "name": "aman-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10557159", "map_id": "none", "name": "FUT3 transfers L-fucose to Gal1,3GlcNAc", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "species_5693930", "map_id": "CHEBI:18915", "name": "Gal1,3GlcNAc group", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_5693933", "map_id": "CHEBI:18914", "name": "Gal1,3Fuc1,4GlcNAc group", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10557156", "map_id": "Q18255", "name": "FUT3", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "WBGene00016163", "map_id": "WBGene00016163", "name": "FUT3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10530588", "map_id": "none", "name": "Addition of a GlcNAc on the alpha 1,4 branch by MGAT2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_975822", "map_id": "CHEBI:60651", "name": "(GlcNAc)4 (Man)3 (Asn)1", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10530585", "map_id": "O17560", "name": "gly-20", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "WBGene00001645", "map_id": "WBGene00001645", "name": "gly-20", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10557151", "map_id": "none", "name": "FUCA1 hydrolyses NGP:1,6-GlcNAc", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_6784247", "map_id": "none", "name": "NGP:1,6-GlcNAc", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_6784248", "map_id": "CHEBI:59520", "name": "NGP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_6784249", "map_id": "CHEBI:2181", "name": "L-fucose", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_10557148", "map_id": "none", "name": "FUCA1 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "true" }, { "id": "P49713", "map_id": "P49713", "name": "FUCA1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012225", "map_id": "WBGene00012225", "name": "FUCA1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10502093", "map_id": "none", "name": "CDC6 protein is synthesized under the control of E2F transcription factors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10508790", "map_id": "none", "name": "Displacement of UNG glycosylase by APEX1 at the AP site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10508670", "map_id": "none", "name": "UNG-1:AP-dsDNA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9U221", "map_id": "Q9U221", "name": "ung-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013241", "map_id": "WBGene00013241", "name": "ung-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10508786", "map_id": "G5EBR7", "name": "exo-3", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10508664", "map_id": "Q9U221", "name": "ung-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10508788", "map_id": "none", "name": "APEX1:AP-dsDNA", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10508792", "map_id": "none", "name": "Displacement of NTHL1 glycosylase by APEX1 at the AP site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10508686", "map_id": "none", "name": "NTHL1:AP-dsDNA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "P54137", "map_id": "P54137", "name": "nth-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011201", "map_id": "WBGene00011201", "name": "nth-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10508657", "map_id": "P54137", "name": "nth-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10529620", "map_id": "none", "name": "Progressive trimming of alpha-1,2-linked mannose residues from Man8GlcNAc2 to produce Man5GlcNAc2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_964831", "map_id": "none", "name": "(GlcNAc)2 (Man)8 glycans", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "CHEBI:60629", "map_id": "CHEBI:60629", "name": "CHEBI:60629", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:60628", "map_id": "CHEBI:60628", "name": "CHEBI:60628", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:60627", "map_id": "CHEBI:60627", "name": "CHEBI:60627", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_964740", "map_id": "CHEBI:59087", "name": "(GlcNAc)2 (Man)5 (Asn)1", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10529593", "map_id": "none", "name": "MAN1A1/A2/C1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "P90787", "map_id": "P90787", "name": "mans-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008411", "map_id": "WBGene00008411", "name": "mans-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q18788", "map_id": "Q18788", "name": "MAN1C1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008258", "map_id": "WBGene00008258", "name": "MAN1C1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10529622", "map_id": "none", "name": "Progressive trimming of alpha-1,2-linked mannose residues from Man7GlcNAc2 to produce Man5GlcNAc2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_964828", "map_id": "CHEBI:60637", "name": "(GlcNAc)2 (Man)7bc", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "reaction_10529596", "map_id": "none", "name": "Progressive trimming of alpha-1,2-linked mannose residues from Man9GlcNAc2 to produce Man5GlcNAc2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_915149", "map_id": "CHEBI:59092", "name": "(GlcNAc)2 (Man)9", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "reaction_10568853", "map_id": "none", "name": "AKT phosphorylates MKRN1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10531086", "map_id": "Q9N373", "name": "lep-2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00002278", "map_id": "WBGene00002278", "name": "lep-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10568851", "map_id": "Q9N373", "name": "phospho-lep-2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10513917", "map_id": "none", "name": "AKT phosphorylates caspase-9", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10509443", "map_id": "none", "name": "Homologues of CASP9(1-416)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10513915", "map_id": "none", "name": "Homologues of p-S196-CASP9(1-416)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10523796", "map_id": "none", "name": "Aquaporin-9 passively transports glycerol into cell", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_192438", "map_id": "CHEBI:17754", "name": "glycerol", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10523793", "map_id": "none", "name": "AQP9 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q7YWQ1", "map_id": "Q7YWQ1", "name": "aqp-12", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013272", "map_id": "WBGene00013272", "name": "aqp-12", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q17571", "map_id": "Q17571", "name": "aqp-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000170", "map_id": "WBGene00000170", "name": "aqp-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7Z138", "map_id": "Q7Z138", "name": "aqp-8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000176", "map_id": "WBGene00000176", "name": "aqp-8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q19949", "map_id": "Q19949", "name": "aqp-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000169", "map_id": "WBGene00000169", "name": "aqp-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XW36", "map_id": "Q9XW36", "name": "aqp-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000171", "map_id": "WBGene00000171", "name": "aqp-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q21473", "map_id": "Q21473", "name": "aqp-7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000175", "map_id": "WBGene00000175", "name": "aqp-7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10523803", "map_id": "none", "name": "Aquaporin-7 passively transports glycerol out of cell", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10523800", "map_id": "none", "name": "AQP7 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10530450", "map_id": "none", "name": "GLRA:GLRB:Gly transports extracellular Cl- to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_188972", "map_id": "CHEBI:17996", "name": "Cl-", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_352022", "map_id": "CHEBI:17996", "name": "Cl-", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10530447", "map_id": "none", "name": "GLRA:GLRB:Gly", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "G5EBR3", "map_id": "G5EBR3", "name": "glc-1", "type": "complex_component", 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For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10527785", "map_id": "none", "name": "O-acteylcholine bound to calcium permeable postsynaptic nicotinic acetylcholine receptors", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "B3WFZ2", "map_id": "B3WFZ2", "name": "acr-19", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000058", "map_id": "WBGene00000058", "name": "acr-19", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10527790", "map_id": "none", "name": "Binding of acetylcholine to highly calcium permeable postsynaptic nicotinic acetylcholine receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10527783", "map_id": "none", "name": "Highly calcium permeable postsynaptic nicotinic acetylcholine receptors", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10527792", "map_id": "none", "name": "Binding of acetylcholine to highly calcium permeable acetylcholine receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10527760", "map_id": "none", "name": "Highly calcium permeable nicotinic acetylcholine receptors", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10527762", "map_id": "none", "name": "0-acteylcholine bound to calcium permeable nictonic acteylcholine receptor complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10527765", "map_id": "none", "name": "Activation of highly calcium permeable nicotinic acetylcholine receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10572694", "map_id": "none", "name": "HTR3A pentamer binds 5HT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10572692", "map_id": "none", "name": "HTR3A pentamer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10571568", "map_id": "none", "name": "p-S363,S380,T573 RS6K translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10571566", "map_id": "none", "name": "p-S221,T359.S363,S380,T573,T732-RSK", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10524491", "map_id": "none", "name": "p-S221,T359,S363,S380,T573,T732-RSK", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10524494", "map_id": "none", "name": "Phosphorylation of CREB1 by ribosomal protein S6 kinases (RSKs)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10572227", "map_id": "none", "name": "CaMKK autophosphorylates in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10572220", "map_id": "none", "name": "CaMKK:CALM1:4xCa2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10572224", "map_id": "none", "name": "p-CaMKK:CALM1:4xCa2+", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10572236", "map_id": "none", "name": "CAMK1 binds calmodulin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10572232", "map_id": "Q9TXJ0", "name": "cmk-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00000553", "map_id": "WBGene00000553", "name": "cmk-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10572234", "map_id": "none", "name": "CAMK1:CALM1:4xCa2+", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9TXJ0", "map_id": "Q9TXJ0", "name": "cmk-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10523910", "map_id": "none", "name": "Ca2+ influx into the post-synaptic cell", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10523907", "map_id": "none", "name": "Gly,D-Ser:L-Glu:GRIN1:GRIN2 NMDA receptors", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "O61967", "map_id": "O61967", "name": "let-413", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002632", "map_id": "WBGene00002632", "name": "let-413", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_376186", "map_id": "CHEBI:16523", "name": "D-Ser", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_9635195", "map_id": "none", "name": "Ifenprodil", "type": "inhibitor", "sub_type": "other", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10524270", "map_id": "none", "name": "Membrane depolarization upon activation of Ca impermeable AMPA receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10521150", "map_id": "none", "name": "Ca impermeable AMPA receptor ligand complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q10914", "map_id": "Q10914", "name": "glr-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001613", "map_id": "WBGene00001613", "name": "glr-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q21415", "map_id": "Q21415", "name": "glr-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001614", "map_id": "WBGene00001614", "name": "glr-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8MXV8", "map_id": "Q8MXV8", "name": "glr-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001617", "map_id": "WBGene00001617", "name": "glr-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34299", "map_id": "P34299", "name": "glr-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001612", "map_id": "WBGene00001612", "name": "glr-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10524268", "map_id": "none", "name": "Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors:p-T286-CaMKII dodecamer:CALM1:4xCa2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10571984", "map_id": "none", "name": "Formation of di-heterotetramers of GluN1 (GRIN1) and GluN2A (GRIN2A)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10571980", "map_id": "G5EEH3", "name": "nmr-2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10571978", "map_id": "G5EGQ9", "name": "nmr-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10571982", "map_id": "none", "name": "GRIN1:GRIN2A di-heterotetramer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10572100", "map_id": "none", "name": "GluN1:GluN2 (GRIN1:GRIN2) NMDA receptors traffic to the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10572098", "map_id": "none", "name": "GRIN1:GRIN2A,C,D di-heteromers, GRIN1:GRIN2 tri-heteromers", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "species_10523874", "map_id": "none", "name": "GRIN1:GRIN2A,C,D di-heteromers,GRIN1:GRIN2 tri-heteromers", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10530193", "map_id": "none", "name": "GABR heteropentamers:GABA transport Cl- from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10530190", "map_id": "none", "name": "GABR heteropentamers:GABA", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q6BET0", "map_id": "Q6BET0", "name": "lgc-36", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008551", "map_id": "WBGene00008551", "name": "lgc-36", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5ECN1", "map_id": "G5ECN1", "name": "lgc-37", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013914", "map_id": "WBGene00013914", "name": "lgc-37", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A5JYS3", "map_id": "A5JYS3", "name": "lgc-24", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00045385", "map_id": "WBGene00045385", "name": "lgc-24", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q17999", "map_id": "Q17999", "name": "lgc-23", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007594", "map_id": "WBGene00007594", "name": "lgc-23", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5ECD3", "map_id": "G5ECD3", "name": "unc-49", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006784", "map_id": "WBGene00006784", "name": "unc-49", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q4W520", "map_id": "Q4W520", "name": "lgc-28", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00044301", "map_id": "WBGene00044301", "name": "lgc-28", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5ECJ0", "map_id": "G5ECJ0", "name": "exp-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001373", "map_id": "WBGene00001373", "name": "exp-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A3P6NNS2", "map_id": "A0A3P6NNS2", "name": "lgc-38", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017389", "map_id": "WBGene00017389", "name": "lgc-38", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9U2E2", "map_id": "Q9U2E2", "name": "lgc-35", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012915", "map_id": "WBGene00012915", "name": "lgc-35", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O18276", "map_id": "O18276", "name": "gab-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001512", "map_id": "WBGene00001512", "name": "gab-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10530517", "map_id": "none", "name": "GABRR pentamers:GABA transports extracellular Cl- to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10530514", "map_id": "none", "name": "GABRR pentamers:GABA", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10531856", "map_id": "none", "name": "Association of GABA B receptor with G protein beta-gamma subunits", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10531752", "map_id": "none", "name": "GABA B receptor G-protein beta-gamma complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10531859", "map_id": "none", "name": "Activation of GIRK/Kir3 Channels", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10531851", "map_id": "none", "name": "GABA B receptor G-protein beta-gamma and Kir3 channel complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "A0A1C3NSK2", "map_id": "A0A1C3NSK2", "name": "irk-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002151", "map_id": "WBGene00002151", "name": "irk-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A1C3NSN6", "map_id": "A0A1C3NSN6", "name": "irk-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002150", "map_id": "WBGene00002150", "name": "irk-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P52192", "map_id": "P52192", "name": "irk-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002149", "map_id": "WBGene00002149", "name": "irk-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10531854", "map_id": "none", "name": "Binding of Gbeta/gamma to GIRK/Kir3 channels", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10531849", "map_id": "none", "name": "Kir heterotetramers", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10522049", "map_id": "none", "name": "Ca permeable AMPA receptor ligand binding", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10521159", "map_id": "none", "name": "Ca permeable AMPA receptors", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10521161", "map_id": "none", "name": "Ca permeable AMPA receptor ligand complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10521153", "map_id": "none", "name": "Activation of Ca impermeable AMPA receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10522051", "map_id": "none", "name": "Activation of Ca permeable AMPA receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10522047", "map_id": "none", "name": "Ca impermeable AMPA receptor ligand binding", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10521148", "map_id": "none", "name": "Ca impermeable AMPA receptors", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10530046", "map_id": "none", "name": "HTR3 pentamers:5HT transport Na+,K+,Ca2+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10530043", "map_id": "none", "name": "HTR3 pentamers:5HT", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10518753", "map_id": "none", "name": "L1 trans-homophilic interaction", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10518718", "map_id": "none", "name": "Homologues of L1CAM", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q21465", "map_id": "Q21465", "name": "phospho-zig-12", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019727", "map_id": "WBGene00019727", "name": "phospho-zig-12", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q5WRR1", "map_id": "Q5WRR1", "name": "phospho-wrk-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006942", "map_id": "WBGene00006942", "name": "phospho-wrk-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10518749", "map_id": "none", "name": "pL1:Ezrin", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "G5EBK3", "map_id": "G5EBK3", "name": "erm-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001333", "map_id": "WBGene00001333", "name": "erm-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10518751", "map_id": "none", "name": "L1 trans-homodimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10524545", "map_id": "none", "name": "Linkage of L1 with treadmilling F-actin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10524543", "map_id": "none", "name": "pL1:ERM:F-actin", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10521063", "map_id": "none", "name": "L1 binds to AP-2 Clathrin complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10512100", "map_id": "none", "name": "Clathrin:AP-2 complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "P34574", "map_id": "P34574", "name": "chc-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011867", "map_id": "WBGene00011867", "name": "chc-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P90961", "map_id": "P90961", "name": "clic-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020246", "map_id": "WBGene00020246", "name": "clic-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10521061", "map_id": "none", "name": "L1:clathrin-coated vesicle", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10527463", "map_id": "none", "name": "Formation of clathrin coated vesicle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10512105", "map_id": "B1V8A0", "name": "unc-57", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "WBGene00006791", "map_id": "WBGene00006791", "name": "unc-57", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10521065", "map_id": "none", "name": "L1:AP-2 Clathrin complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20592", "compartment_display": "clathrin-coated endocytic vesicle", "complex": "true" }, { "id": "B1V8A0", "map_id": "B1V8A0", "name": "unc-57", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10512940", "map_id": "none", "name": "Dynamin", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10524730", "map_id": "none", "name": "Phosphorylation of L1 by ERK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10524727", "map_id": "none", "name": "pL1 (S1204, 1248):ERK2:clathrin-dynamin complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17940", "compartment_display": "endosome", "complex": "true" }, { "id": "reaction_10521067", "map_id": "none", "name": "Transport of L1 into endosomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17940", "compartment_display": "endosome" }, { "id": "reaction_10524732", "map_id": "none", "name": "Phosphorylation of L1 by SRC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10518747", "map_id": "none", "name": "Homologues of p-Y1176-L1CAM", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10524556", "map_id": "none", "name": "Interaction of NUMB with L1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10524552", "map_id": "none", "name": "CRMP-2:NUMB:alpha adaptin", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q18677", "map_id": "Q18677", "name": "phospho-dhp-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000964", "map_id": "WBGene00000964", "name": "phospho-dhp-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q21773", "map_id": "Q21773", "name": "phospho-dhp-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000963", "map_id": "WBGene00000963", "name": "phospho-dhp-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q01630", "map_id": "Q01630", "name": "phospho-unc-33", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006769", "map_id": "WBGene00006769", "name": "phospho-unc-33", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10524554", "map_id": "none", "name": "L1:NUMB:CRMP-2:alpha-adaptin", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20592", "compartment_display": "clathrin-coated endocytic vesicle", "complex": "true" }, { "id": "reaction_10566112", "map_id": "none", "name": "AP-2 (TFAP2) transcription factors form homo- and heterodimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10566108", "map_id": "none", "name": "TFAP2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q09585", "map_id": "Q09585", "name": "aptf-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019424", "map_id": "WBGene00019424", "name": "aptf-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q19862", "map_id": "Q19862", "name": "aptf-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009203", "map_id": "WBGene00009203", "name": "aptf-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q19863", "map_id": "Q19863", "name": "aptf-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009202", "map_id": "WBGene00009202", "name": "aptf-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G2HK15", "map_id": "G2HK15", "name": "aptf-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013383", "map_id": "WBGene00013383", "name": "aptf-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10566110", "map_id": "none", "name": "TFAP2 homo- and heterodimers", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10566136", "map_id": "none", "name": "TFAP2B homodimer binds YEATS4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10566132", "map_id": "none", "name": "TFAP2B homodimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10566130", "map_id": "Q21501", "name": "gfl-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00001585", "map_id": "WBGene00001585", "name": "gfl-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10566134", "map_id": "none", "name": "TFAP2B homodimer:YEATS4", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q21501", "map_id": "Q21501", "name": "gfl-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10566124", "map_id": "none", "name": "TFAP2C translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10566118", "map_id": "Q09585", "name": "aptf-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10546739", "map_id": "Q09585", "name": "aptf-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10566120", "map_id": "none", "name": "TFAP2C:WWOX", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10546753", "map_id": "none", "name": "SUMOylation of TFAP2C with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10546741", "map_id": "none", "name": "TFAP2C homodimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10546751", "map_id": "none", "name": "SUMO1:TFAP2C homodimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10566122", "map_id": "none", "name": "WWOX binds TFAP2C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10529266", "map_id": "none", "name": "Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10529262", "map_id": "none", "name": "Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10529242", "map_id": "O76512", "name": "smg-2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10529264", "map_id": "none", "name": "UPF1:eRF3 Complex on Translated mRNA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10508129", "map_id": "none", "name": "Activation of GT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10508127", "map_id": "none", "name": "RNA Pol II with phosphorylated CTD: CE complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q17607", "map_id": "Q17607", "name": "cel-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000466", "map_id": "WBGene00000466", "name": "cel-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10508162", "map_id": "none", "name": "Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10508155", "map_id": "none", "name": "Capping complex (initial)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9XVS1", "map_id": "Q9XVS1", "name": "tag-72", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006447", "map_id": "WBGene00006447", "name": "tag-72", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10508159", "map_id": "none", "name": "Capping complex (hydrolyzed)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10508178", "map_id": "none", "name": "Dissociation of transcript with 5'-GMP from GT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10508171", "map_id": "none", "name": "Capping complex (GpppN..)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10508176", "map_id": "none", "name": "Capping complex (with freed 5'- GMP)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10508133", "map_id": "none", "name": "RNA Polymerase II CTD (phosphorylated) binds to CE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10508125", "map_id": "Q17607", "name": "cel-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10508131", "map_id": "none", "name": "Pol II transcription complex with (ser5) phosphorylated CTD containing extruded transcript to +30", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10508183", "map_id": "none", "name": "Methylation of GMP-cap by RNA Methyltransferase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10506316", "map_id": "none", "name": "TFIIH", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10504425", "map_id": "none", "name": "RNA Polymerase II (phosphorylated):TFIIF:capped pre-mRNA", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10508149", "map_id": "Q21338", "name": "phospho-spt-5", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10508180", "map_id": "none", "name": "mRNA capping factors", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10508169", "map_id": "none", "name": "Formation of the CE:GMP intermediate complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_113571", "map_id": "CHEBI:15996", "name": "GTP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10508166", "map_id": "none", "name": "Capping complex (intermediate)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_111349", "map_id": "CHEBI:17552", "name": "GDP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10508185", "map_id": "none", "name": "Formation of cap binding complex (CBC)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10504344", "map_id": "O01763", "name": "ncbp-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10504339", "map_id": "Q93594", "name": "ncbp-2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10504346", "map_id": "none", "name": "Cap Binding Complex (CBC)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10508153", "map_id": "none", "name": "SPT5 subunit of Pol II binds the RNA triphosphatase (RTP)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10508143", "map_id": "Q9XVS1", "name": "tag-72", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10508151", "map_id": "none", "name": "CE:Pol II CTD:Spt5 complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10508187", "map_id": "none", "name": "Recognition and binding of the mRNA cap by the cap-binding complex ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10504427", "map_id": "none", "name": "capped pre-mRNA:CBC:RNA Pol II (phosphorylated) complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10508157", "map_id": "none", "name": "Capping complex formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_72084", "map_id": "none", "name": "nascent pre-mRNA transcript", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_29428", "map_id": "none", "name": "DNA", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10508174", "map_id": "none", "name": "Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10508321", "map_id": "none", "name": "Cleavage of the 3'-end of Replication Dependent Histone Pre-mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10508315", "map_id": "none", "name": "Capped Intronless Histone pre-mRNA:CBP80:CBP20:SLBP:ZFP100 Complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q09599", "map_id": "Q09599", "name": "cdl-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000411", "map_id": "WBGene00000411", "name": "cdl-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q20709", "map_id": "Q20709", "name": "tra-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018740", "map_id": "WBGene00018740", "name": "tra-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "V6CKC3", "map_id": "V6CKC3", "name": "ZNF473", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021689", "map_id": "WBGene00021689", "name": "ZNF473", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7YWY5", "map_id": "Q7YWY5", "name": "LSM10", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010619", "map_id": "WBGene00010619", "name": "LSM10", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9GYQ8", "map_id": "Q9GYQ8", "name": "LSM11", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016791", "map_id": "WBGene00016791", "name": "LSM11", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10508319", "map_id": "none", "name": "Mature Intronless transcript derived Histone mRNA:SLBP:CBP80:CBP20", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10508313", "map_id": "none", "name": "U7 snRNP:ZNF473", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10508283", "map_id": "none", "name": "Binding of SLBP to Replication-Dependent Histone Pre-mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10508279", "map_id": "Q09599", "name": "cdl-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10508274", "map_id": "none", "name": "Capped Intronless Histone pre-mRNA:CBC complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10508281", "map_id": "none", "name": "Capped Intronless Histone pre-mRNA:CBP80:CBP20:SLBP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10508317", "map_id": "none", "name": "Recruitment of U7 snRNP:ZFP100 complex to the SLBP Bound Pre-mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10508337", "map_id": "none", "name": "Binding of Cleavage factors and Poly(A)Polymerase to the CstF:CPSF:Pre-mRNA Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10508331", "map_id": "none", "name": "CstF:CPSF:capped intronless pre-mRNA:CBC complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10508335", "map_id": "none", "name": "intronless pre-mRNA cleavage complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10508341", "map_id": "none", "name": "Cleavage of Intronless Pre-mRNA at 3'-end", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_112165", "map_id": "none", "name": "downstream intronless mRNA fragment", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10508339", "map_id": "none", "name": "upstream mRNA fragment:CPSF:PAP:PABPN1 complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10508329", "map_id": "none", "name": "Recognition of AAUAAA sequence by CPSF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10508325", "map_id": "none", "name": "capped intronless pre-mRNA:CBC complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10508327", "map_id": "none", "name": "CPSF:capped intronless pre-mRNA:CBC complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10508345", "map_id": "none", "name": "Cleavage and polyadenylation of Intronless Pre-mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10508343", "map_id": "none", "name": "Mature intronless derived mRNA complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10508333", "map_id": "none", "name": "Recruitment of CstF to the CPSF Bound Pre-mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10508842", "map_id": "none", "name": "Cleavage of the 3'-end of the Histone Pre-mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10508838", "map_id": "none", "name": "Capped Intronless Histone pre-mRNA:CBC:ZFP100 Complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10508840", "map_id": "none", "name": "Mature intronless transcript derived Histone pre-mRNA:CBC complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10508844", "map_id": "none", "name": "Recruitment of U7 snRNP:ZFP100 complex to the Histone Pre-mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10527075", "map_id": "none", "name": "p-S54,92,203-BRF1 binds 14-3-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10525899", "map_id": "none", "name": "Phosphorylated BRF1 (Ser54, Ser92, Ser203):mRNA Complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "G5EC86", "map_id": "G5EC86", "name": "phospho-oma-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003864", "map_id": "WBGene00003864", "name": "phospho-oma-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q09436", "map_id": "Q09436", "name": "phospho-mex-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003231", "map_id": "WBGene00003231", "name": "phospho-mex-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XUB2", "map_id": "Q9XUB2", "name": "phospho-mex-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003230", "map_id": "WBGene00003230", "name": "phospho-mex-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5ECB9", "map_id": "G5ECB9", "name": "phospho-mex-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003228", "map_id": "WBGene00003228", "name": "phospho-mex-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q20155", "map_id": "Q20155", "name": "phospho-ccch-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009532", "map_id": "WBGene00009532", "name": "phospho-ccch-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XV46", "map_id": "Q9XV46", "name": "phospho-moe-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003388", "map_id": "WBGene00003388", "name": "phospho-moe-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EF15", "map_id": "G5EF15", "name": "phospho-pos-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004078", "map_id": "WBGene00004078", "name": "phospho-pos-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q23359", "map_id": "Q23359", "name": "phospho-oma-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003865", "map_id": "WBGene00003865", "name": "phospho-oma-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O02289", "map_id": "O02289", "name": "phospho-gla-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011376", "map_id": "WBGene00011376", "name": "phospho-gla-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q94131", "map_id": "Q94131", "name": "phospho-pie-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004027", "map_id": "WBGene00004027", "name": "phospho-pie-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O18251", "map_id": "O18251", "name": "phospho-ccch-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013319", "map_id": "WBGene00013319", "name": "phospho-ccch-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9U1Y2", "map_id": "Q9U1Y2", "name": "phospho-p-S54,S92,S203-p-ZFP36L1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013797", "map_id": "WBGene00013797", "name": "phospho-p-S54,S92,S203-p-ZFP36L1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O45289", "map_id": "O45289", "name": "phospho-p-S54,S92,S203-p-ZFP36L1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9U2V1", "map_id": "Q9U2V1", "name": "phospho-p-S54,S92,S203-p-ZFP36L1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O45491", "map_id": "O45491", "name": "phospho-ccch-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009537", "map_id": "WBGene00009537", "name": "phospho-ccch-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9U2V2", "map_id": "Q9U2V2", "name": "phospho-p-S54,S92,S203-p-ZFP36L1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O45493", "map_id": "O45493", "name": "phospho-p-S54,S92,S203-p-ZFP36L1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9U2V4", "map_id": "Q9U2V4", "name": "phospho-dct-13", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013794", "map_id": "WBGene00013794", "name": "phospho-dct-13", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10507065", "map_id": "none", "name": "Homologues of YWHAB", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10527073", "map_id": "none", "name": "Phosphorylated BRF1 (Ser54, Ser92, Ser203):mRNA:14-3-3 Complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10525750", "map_id": "none", "name": "p-S92,203-BRF1 binds 14-3-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10525746", "map_id": "none", "name": "Phosphorylated BRF1 (Ser92, Ser203):mRNA Complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10525748", "map_id": "none", "name": "Phosphorylated BRF1 (Ser92, Ser203):mRNA:14-3-3 Complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10525911", "map_id": "none", "name": "BRF1 Complex recruits RNA degradation activities", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10525823", "map_id": "none", "name": "BRF1:mRNA Complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10523562", "map_id": "Q9N363", "name": "dcap-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00021929", "map_id": "WBGene00021929", "name": "dcap-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10523671", "map_id": "none", "name": "Exosome Complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q17632", "map_id": "Q17632", "name": "dis-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001001", "map_id": "WBGene00001001", "name": "dis-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10525907", "map_id": "Q9BHK7", "name": "xrn-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00012730", "map_id": "WBGene00012730", "name": "xrn-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10523569", "map_id": "O62255", "name": "dcap-2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00003582", "map_id": "WBGene00003582", "name": "dcap-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10525909", "map_id": "none", "name": "BRF1:mRNA Degradation Complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "O62255", "map_id": "O62255", "name": "dcap-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9BHK7", "map_id": "Q9BHK7", "name": "xrn-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9N363", "map_id": "Q9N363", "name": "dcap-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10525914", "map_id": "none", "name": "Protein Kinase B/Akt phosphorylates BRF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10525932", "map_id": "none", "name": "Butyrate Response Factor1 (BRF1) binds AU-rich element in 3' UTR of mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_450523", "map_id": "none", "name": "mRNA Transcript Targeted by BRF1", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10525821", "map_id": "none", "name": "Homologues of ZFP36L1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10525902", "map_id": "none", "name": "MK2 phosphorylates BRF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10512640", "map_id": "none", "name": "Homologues of p-S272,T222,T334-MAPKAPK2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10525984", "map_id": "none", "name": "p-S193-KSRP binds 14-3-3zeta in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10525928", "map_id": "none", "name": "Homologues of p-S193-KHSRP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q17936", "map_id": "Q17936", "name": "phospho-fubl-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007534", "map_id": "WBGene00007534", "name": "phospho-fubl-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q23487", "map_id": "Q23487", "name": "phospho-fubl-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022738", "map_id": "WBGene00022738", "name": "phospho-fubl-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9BLA0", "map_id": "Q9BLA0", "name": "phospho-fubl-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016489", "map_id": "WBGene00016489", "name": "phospho-fubl-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P91393", "map_id": "P91393", "name": "phospho-fubl-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019692", "map_id": "WBGene00019692", "name": "phospho-fubl-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10525970", "map_id": "none", "name": "Homologues of YWHAZ", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10525982", "map_id": "none", "name": "Phosphorylated KSRP (Ser193):14-3-3zeta Complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10525783", "map_id": "none", "name": "KSRP recruits RNA degradation activities", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10525774", "map_id": "none", "name": "KSRP:mRNA Complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10525779", "map_id": "Q21412", "name": "parn-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00010734", "map_id": "WBGene00010734", "name": "parn-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10525781", "map_id": "none", "name": "KSRP:mRNA Degradation Complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q21412", "map_id": "Q21412", "name": "parn-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10525930", "map_id": "none", "name": "Protein Kinase B (AKT) phosphorylates KSRP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10525772", "map_id": "none", "name": "Homologues of KSRP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10525964", "map_id": "none", "name": "KSRP binds AU-rich element in 3' UTR of mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_450386", "map_id": "none", "name": "mRNA Transcript Targeted by KSRP", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10513160", "map_id": "none", "name": "snRNA Cap hypermethylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10513152", "map_id": "none", "name": "Spliceosomal m7G capped snRNAs with SMN:SM protein complex bound", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "G5ED26", "map_id": "G5ED26", "name": "mel-46", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020284", "map_id": "WBGene00020284", "name": "mel-46", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EC16", "map_id": "G5EC16", "name": "smn-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004887", "map_id": "WBGene00004887", "name": "smn-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34399", "map_id": "P34399", "name": "GEMIN8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017357", "map_id": "WBGene00017357", "name": "GEMIN8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O01871", "map_id": "O01871", "name": "GEMIN6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017002", "map_id": "WBGene00017002", "name": "GEMIN6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9N405", "map_id": "Q9N405", "name": "smi-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004886", "map_id": "WBGene00004886", "name": "smi-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A7LPI7", "map_id": "A7LPI7", "name": "GEMIN7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007702", "map_id": "WBGene00007702", "name": "GEMIN7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:2274", "map_id": "CHEBI:2274", "name": "CHEBI:2274", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10513139", "map_id": "none", "name": "Spliceosomal m3G capped snRNAs with SMN:SM protein complex bound", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:1604", "map_id": "CHEBI:1604", "name": "CHEBI:1604", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10513157", "map_id": "Q94013", "name": "TGS1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00011631", "map_id": "WBGene00011631", "name": "TGS1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10513148", "map_id": "none", "name": "snRNP:Snurportin complex formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10513144", "map_id": "O17066", "name": "SNUPN", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00017746", "map_id": "WBGene00017746", "name": "SNUPN", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10513146", "map_id": "none", "name": "Spliceosomal m3G capped snRNA:SMN:SM:Snurportin complex ", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "O17066", "map_id": "O17066", "name": "SNUPN", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10523617", "map_id": "none", "name": "PAN2-PAN3 complex partially deadenylates mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10523602", "map_id": "none", "name": "Translatable mRNA Complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "H2L0A8", "map_id": "H2L0A8", "name": "EIF4B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019157", "map_id": "WBGene00019157", "name": "EIF4B", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10523590", "map_id": "none", "name": "Partially Deadenylated mRNA Complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10523614", "map_id": "none", "name": "PAN2-PAN3 Complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P53015", "map_id": "P53015", "name": "PAN2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017951", "map_id": "WBGene00017951", "name": "PAN2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34653", "map_id": "P34653", "name": "panl-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00014015", "map_id": "WBGene00014015", "name": "panl-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10568671", "map_id": "none", "name": "ZCCHC6, ZCCHC11 are mRNA uridyltransferases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_6782337", "map_id": "CHEBI:73747", "name": "uridine residue", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10568627", "map_id": "none", "name": "Uridylated partially Deadenylated mRNA Complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10568668", "map_id": "none", "name": "ZCCHC6, ZCCHC11", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q09409", "map_id": "Q09409", "name": "cid-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019629", "map_id": "WBGene00019629", "name": "cid-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O02094", "map_id": "O02094", "name": "ZCCHC6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00194706", "map_id": "WBGene00194706", "name": "ZCCHC6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O44768", "map_id": "O44768", "name": "mut-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003499", "map_id": "WBGene00003499", "name": "mut-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q20377", "map_id": "Q20377", "name": "ZCCHC6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EFR3", "map_id": "G5EFR3", "name": "ZCCHC6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "L8E6M1", "map_id": "L8E6M1", "name": "ZCCHC6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q09408", "map_id": "Q09408", "name": "pup-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019628", "map_id": "WBGene00019628", "name": "pup-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10523600", "map_id": "none", "name": "Lsm1-7 Complex binds deadenylated mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10523548", "map_id": "none", "name": "Lsm1-7 Complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q20229", "map_id": "Q20229", "name": "lsm-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003076", "map_id": "WBGene00003076", "name": "lsm-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q20374", "map_id": "Q20374", "name": "patr-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009661", "map_id": "WBGene00009661", "name": "patr-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_429974", "map_id": "none", "name": "mature mRNA (eukaryotic, capped and deadenylated)", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10523550", "map_id": "none", "name": "Deadenylated mRNA:Lsm1-7 Complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10523584", "map_id": "none", "name": "DCP1-DCP2 complex decaps mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_430004", "map_id": "CHEBI:20794", "name": "7-MeGDP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10523552", "map_id": "none", "name": "Decapped mRNA:LSM1-7 Complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10523581", "map_id": "none", "name": "DCP1-DCP2 Decapping Complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q21740", "map_id": "Q21740", "name": "edc-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011036", "map_id": "WBGene00011036", "name": "edc-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8ITV6", "map_id": "Q8ITV6", "name": "edc-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021551", "map_id": "WBGene00021551", "name": "edc-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q95YF3", "map_id": "Q95YF3", "name": "cgh-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000479", "map_id": "WBGene00000479", "name": "cgh-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10557208", "map_id": "none", "name": "NT5C3B hydrolyses 7MGP to 7MG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_430042", "map_id": "CHEBI:17825", "name": "7MGMP", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_5694090", "map_id": "CHEBI:20794", "name": "7MG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10557205", "map_id": "Q09315", "name": "NT5C3B", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00017775", "map_id": "WBGene00017775", "name": "NT5C3-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10523598", "map_id": "none", "name": "DCPS scavenges the 7-methylguanosine cap of mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_429926", "map_id": "none", "name": "capped oligoribonucleotide", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_429925", "map_id": "none", "name": "oligoribonucleotide with a 5'-diphosphate", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10523595", "map_id": "G5EFS4", "name": "dcs-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00000940", "map_id": "WBGene00000940", "name": "dcs-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10523695", "map_id": "none", "name": "Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10523692", "map_id": "none", "name": "Exosome:SKI complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9BKR2", "map_id": "Q9BKR2", "name": "ttc-37", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021613", "map_id": "WBGene00021613", "name": "ttc-37", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A5Z2V7", "map_id": "A5Z2V7", "name": "WDR61", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008533", "map_id": "WBGene00008533", "name": "WDR61", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q19103", "map_id": "Q19103", "name": "skih-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008502", "map_id": "WBGene00008502", "name": "skih-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P90922", "map_id": "P90922", "name": "HBS1L", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010622", "map_id": "WBGene00010622", "name": "HBS1L", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10567172", "map_id": "none", "name": "MET phosphorylates PTK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10567169", "map_id": "none", "name": "HGF:p-4Y-MET dimer:p-Y397-PTK2:MyrG-p-Y419-SRC", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10567156", "map_id": "none", "name": "HGF:p-4Y-MET dimer:p-Y194,Y397-PTK2:MyrG-p-Y419-SRC", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10567165", "map_id": "none", "name": "SRC phosphorylates PTK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10567162", "map_id": "none", "name": "HGF:p-4Y-MET dimer:p-Y194,Y397,Y576,Y577-PTK2:MyrG-p-Y419-SRC", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10548900", "map_id": "none", "name": "WNT:FZD complex promotes G-protein nucleotide exchange", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10548893", "map_id": "none", "name": "WNT5A/11:FZD:G-protein (alpha o/t2) inactive", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9N532", "map_id": "Q9N532", "name": "mig-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003238", "map_id": "WBGene00003238", "name": "mig-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EDV1", "map_id": "G5EDV1", "name": "lin-17", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003006", "map_id": "WBGene00003006", "name": "lin-17", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A0K3AWM6", "map_id": "A0A0K3AWM6", "name": "mom-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "T23D8.1b", "map_id": "T23D8.1b", "name": "mom-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5ECQ2", "map_id": "G5ECQ2", "name": "cfz-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000478", "map_id": "WBGene00000478", "name": "cfz-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P51875", "map_id": "P51875", "name": "goa-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001648", "map_id": "WBGene00001648", "name": "goa-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10548897", "map_id": "none", "name": "WNT5A/11:FZD:G-protein (alpha o/t2) active", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10549076", "map_id": "none", "name": "Dissociation of CaM and CAMK2 autophosphorylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10549073", "map_id": "none", "name": "p-T286 CAMK2:CaM", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10549071", "map_id": "none", "name": "p-T286,T305,T306-CAMK2A", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10548902", "map_id": "none", "name": "G-protein subunits dissociate from WNT:FZD complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10548887", "map_id": "none", "name": "G-protein alpha (o/t2)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10548880", "map_id": "none", "name": "WNT5A/11:FZD", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10549082", "map_id": "none", "name": "Active calmodulin binds CAMK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10523903", "map_id": "none", "name": "CaMKII dodecamer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10549078", "map_id": "none", "name": "CAMK2:CaM", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10549080", "map_id": "none", "name": "S-Farn-Me KRAS4B:CALM1:4xCa2+", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10549228", "map_id": "none", "name": "Translocation of NFATC1:CaN:CaM to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10549222", "map_id": "none", "name": "NFATC1:CaN:CaM", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q0G819", "map_id": "Q0G819", "name": "tax-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006527", "map_id": "WBGene00006527", "name": "tax-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_912516", "map_id": "CHEBI:29034", "name": "Fe3+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "G5EDN6", "map_id": "G5EDN6", "name": "cnb-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000554", "map_id": "WBGene00000554", "name": "cnb-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10549226", "map_id": "none", "name": "NFATC1:CaN:CaM", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10545533", "map_id": "none", "name": "Activation of Calcineurin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10541838", "map_id": "none", "name": "Calcineurin (CaN)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10545507", "map_id": "none", "name": "Calcineurin:Calmodulin (CaN:CaM)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10549086", "map_id": "none", "name": "Autophosphorylation and activation of CAMK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10549150", "map_id": "none", "name": "NLK phosphorylates TCF/LEF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10549137", "map_id": "none", "name": "TCF/LEF:CTNNB1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10549147", "map_id": "none", "name": "p-TCF/LEF:CTNNB1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10549133", "map_id": "none", "name": "pT298-NLK dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9U9Y8", "map_id": "Q9U9Y8", "name": "phospho-lit-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003048", "map_id": "WBGene00003048", "name": "phospho-lit-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10549135", "map_id": "none", "name": "NLK translocates to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10549129", "map_id": "none", "name": "pT298-NLK dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10508197", "map_id": "none", "name": "(S)-3-Hydroxydodecanoyl-CoA+NAD<=>3-Oxododecanoyl-CoA+NADH+H", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_77252", "map_id": "CHEBI:27668", "name": "(S)-3-Hydroxydodecanoyl-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_77253", "map_id": "CHEBI:27868", "name": "3-Oxododecanoyl-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10508194", "map_id": "none", "name": "HADH dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "P41938", "map_id": "P41938", "name": "HADH", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007129", "map_id": "WBGene00007129", "name": "HADH", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10508199", "map_id": "none", "name": "2-trans-Dodecenoyl-CoA+H2O<=>(S)-3-Hydroxydodecanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_77255", "map_id": "CHEBI:15471", "name": "2-trans-Dodecenoyl-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10503463", "map_id": "none", "name": "ECHS1 hexamer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "P34559", "map_id": "P34559", "name": "ech-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001155", "map_id": "WBGene00001155", "name": "ech-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10508238", "map_id": "none", "name": "3-Oxododecanoyl-CoA+CoA-SH<=>Decanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_77308", "map_id": "CHEBI:28493", "name": "DEC-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_113559", "map_id": "CHEBI:15351", "name": "Ac-CoA", "type": "catalyst", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10508211", "map_id": "none", "name": "Trifunctional Protein", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "P34255", "map_id": "P34255", "name": "HADHB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00015125", "map_id": "WBGene00015125", "name": "HADHB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9GYT0", "map_id": "Q9GYT0", "name": "ech-1.2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020347", "map_id": "WBGene00020347", "name": "ech-1.2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10570192", "map_id": "none", "name": "CUBN dissociates from 25(OH)D", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_10570190", "map_id": "none", "name": "CUBN:25(OH)D", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "true" }, { "id": "Q93212", "map_id": "Q93212", "name": "sol-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004944", "map_id": "WBGene00004944", "name": "sol-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_8963879", "map_id": "CHEBI:17933", "name": "25(OH)D", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10570188", "map_id": "Q93212", "name": "sol-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_350136", "map_id": "CHEBI:17933", "name": "25(OH)D", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "reaction_10516418", "map_id": "none", "name": "CYP2R1 25-hydroxylates VD3 to 25(OH)D", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_8963870", "map_id": "CHEBI:28940", "name": "VD3", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10516415", "map_id": "Q27482", "name": "cyp-33e1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "reaction_10516354", "map_id": "none", "name": "CYP24A1 hydroxylates 1,25(OH)2D, inactivating it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane" }, { "id": "species_209800", "map_id": "CHEBI:17823", "name": "1,25(OH)2D", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_350159", "map_id": "CHEBI:47828", "name": "CTA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10516351", "map_id": "none", "name": "Homologues of CYP24A1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "G5EGT6", "map_id": "G5EGT6", "name": "cyp-31a2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010354", "map_id": "WBGene00010354", "name": "cyp-31a2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O17851", "map_id": "O17851", "name": "cyp-37b1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009226", "map_id": "WBGene00009226", "name": "cyp-37b1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O45219", "map_id": "O45219", "name": "cyp-29a4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007140", "map_id": "WBGene00007140", "name": "cyp-29a4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q09660", "map_id": "Q09660", "name": "cyp-44A1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000375", "map_id": "WBGene00000375", "name": "cyp-44A1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9N525", "map_id": "Q9N525", "name": "cyp-29a3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021412", "map_id": "WBGene00021412", "name": "cyp-29a3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9N574", "map_id": "Q9N574", "name": "cyp-31a3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021200", "map_id": "WBGene00021200", "name": "cyp-31a3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XVA6", "map_id": "Q9XVA6", "name": "cyp-37a1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008499", "map_id": "WBGene00008499", "name": "cyp-37a1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EC97", "map_id": "G5EC97", "name": "cyp-29a2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011830", "map_id": "WBGene00011830", "name": "cyp-29a2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_29532", "map_id": "CHEBI:15824", "name": "Fru", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10570196", "map_id": "none", "name": "1,25(OH)2D binds VDR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10519369", "map_id": "none", "name": "Homologues of VDR", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q94407", "map_id": "Q94407", "name": "nhr-48", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003638", "map_id": "WBGene00003638", "name": "nhr-48", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XYB7", "map_id": "Q9XYB7", "name": "nhr-8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003607", "map_id": "WBGene00003607", "name": "nhr-8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EFF5", "map_id": "G5EFF5", "name": "daf-12", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000908", "map_id": "WBGene00000908", "name": "daf-12", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_8963912", "map_id": "CHEBI:17823", "name": "1,25(OH)2D", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10570194", "map_id": "none", "name": "1,25(OH)2D:VDR", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10551658", "map_id": "none", "name": "DNA ligase I ligates single stranded nick in double stranded DNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_5358610", "map_id": "none", "name": "DNA containing single strand nick (5' phosphate, 3' hydroxyl)", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_109966", "map_id": "none", "name": "Repaired double-stranded DNA", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10544314", "map_id": "none", "name": "DDR2 binds collagen type I, II, III, V, X fibrils", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10544310", "map_id": "none", "name": "Collagen type I, II, III, V, X fibrils", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10544308", "map_id": "none", "name": "DDR2 dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q95ZV7", "map_id": "Q95ZV7", "name": "ddr-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017381", "map_id": "WBGene00017381", "name": "ddr-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10544312", "map_id": "none", "name": "DDR2 dimer:Collagen type I, II, III, V, X fibrils", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10543934", "map_id": "none", "name": "DDR1 binds collagen type I, II, III, IV, V, XI fibrils", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10543930", "map_id": "none", "name": "Collagen type I, II, III, IV, V, XI fibrils", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10543928", "map_id": "none", "name": "DDR1 dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10543932", "map_id": "none", "name": "DDR1 dimer:Collagen type I, II, III, IV, V, XI fibrils", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10508096", "map_id": "none", "name": "CYP4A11 12-hydroxylates DDCX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17960", "compartment_display": "smooth endoplasmic reticulum" }, { "id": "species_156540", "map_id": "CHEBI:15378", "name": "H+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_42373", "map_id": "CHEBI:39567", "name": "12OH-DDCX", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10508093", "map_id": "none", "name": "Cytochrome P450 (CYP4A11 based)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10516947", "map_id": "none", "name": "CYP4F12 18-hydroxylates ARA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17960", "compartment_display": "smooth endoplasmic reticulum" }, { "id": "species_140356", "map_id": "CHEBI:15843", "name": "ARA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_352318", "map_id": "CHEBI:63590", "name": "18OH-ARA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10516944", "map_id": "none", "name": "Cytochrome P450 (CYP4F12 based)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10517062", "map_id": "none", "name": "CYP2J2 oxidises ARA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17960", "compartment_display": "smooth endoplasmic reticulum" }, { "id": "species_215062", "map_id": "none", "name": "cis-EET", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "species_10517059", "map_id": "none", "name": "Cytochrome P450 (CYP2J2 based)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10516957", "map_id": "none", "name": "CYP4B1 12-hydroxylates ARA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17960", "compartment_display": "smooth endoplasmic reticulum" }, { "id": "species_215075", "map_id": "CHEBI:19138", "name": "12-HETE", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10516954", "map_id": "none", "name": "Cytochrome P450 (CYP4B1 based)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10558194", "map_id": "none", "name": "CYP4V2 omega-hydroxylates DHA to HDoHE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_6786220", "map_id": "CHEBI:36005", "name": "DHA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_6786225", "map_id": "CHEBI:72790", "name": "hydroxydocosahexaenoic acid", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10558191", "map_id": "Q9U1R5", "name": "cyp-42a1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "WBGene00013585", "map_id": "WBGene00013585", "name": "cyp-42a1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10513355", "map_id": "none", "name": "CYP19A1 hydroxylates ANDST to E1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_193066", "map_id": "CHEBI:17263", "name": "E1", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10513352", "map_id": "none", "name": "Homologues of CYP19A1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10516928", "map_id": "none", "name": "CYP4F2, 4F3 20-hydroxylate LTB4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_2161636", "map_id": "CHEBI:15646", "name": "20OH-LTB4", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10516925", "map_id": "none", "name": "Cytochrome P450 (CYP4F2/4F3 based)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10552597", "map_id": "none", "name": "CYP4F22 20-hydroxylates TrXA3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_2142713", "map_id": "CHEBI:15630", "name": "TrXA3", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_5602281", "map_id": "CHEBI:83782", "name": "20OH-TrXA3", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10508091", "map_id": "none", "name": "Homologues of CYP4F22", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10516952", "map_id": "none", "name": "CYP4F8 19-hydroxylates PGH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17960", "compartment_display": "smooth endoplasmic reticulum" }, { "id": "species_30138", "map_id": "CHEBI:15554", "name": "PGH2", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_215545", "map_id": "CHEBI:63912", "name": "19OH-PGH2", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10516949", "map_id": "none", "name": "Cytochrome P450 (CYP4F8 based)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10517164", "map_id": "none", "name": "CYP4F3 20-hydroxylates LTB4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17960", "compartment_display": "smooth endoplasmic reticulum" }, { "id": "species_215557", "map_id": "CHEBI:15647", "name": "LTB4", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_571314", "map_id": "CHEBI:15646", "name": "20OH-LTB4", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "reaction_10516959", "map_id": "none", "name": "CYP24A1 24-hydroxylates CTL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_215607", "map_id": "CHEBI:17823", "name": "CTL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_215622", "map_id": "CHEBI:63911", "name": "CTLA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10507989", "map_id": "none", "name": "O-atom dealkylation of dextromethorphan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_39703", "map_id": "none", "name": "DEXM", "type": "reactant", "sub_type": "other", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_143501", "map_id": "CHEBI:16842", "name": "CH2O", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_76455", "map_id": "none", "name": "DEXT", "type": "product", "sub_type": "other", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10507986", "map_id": "none", "name": "Cytochrome P450 (CYP2D6 based)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10517052", "map_id": "none", "name": "CYP2D6 4-hydroxylates debrisoquine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_211993", "map_id": "CHEBI:34665", "name": "DSQ", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_211952", "map_id": "CHEBI:63800", "name": "HDBQ", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "reaction_10517057", "map_id": "none", "name": "CYP2W1 oxidises INDOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17960", "compartment_display": "smooth endoplasmic reticulum" }, { "id": "species_216547", "map_id": "CHEBI:16881", "name": "INDOL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_216598", "map_id": "CHEBI:31697", "name": "Oxindole", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10517054", "map_id": "none", "name": "Cytochrome P450 (CYP2W1 based)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10517044", "map_id": "none", "name": "CYP2U1 19-hydroxylates ARA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17960", "compartment_display": "smooth endoplasmic reticulum" }, { "id": "species_216620", "map_id": "CHEBI:63998", "name": "19HETE", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10517041", "map_id": "none", "name": "Homologues of CYP2U1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10517049", "map_id": "none", "name": "CYP4F11 16-hydroxylates 3OH-PALM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17960", "compartment_display": "smooth endoplasmic reticulum" }, { "id": "species_216621", "map_id": "CHEBI:37248", "name": "3OH-PALM", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_216612", "map_id": "CHEBI:63904", "name": "3,16DOH-PALM", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10517046", "map_id": "none", "name": "Cytochrome P450 (CYP4F11 based)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10545531", "map_id": "none", "name": "Translocation of CaN:CaM:NFAT to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10545511", "map_id": "none", "name": "NFAT:CaN:CaM", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10545529", "map_id": "none", "name": "NFAT:CaN:CaM", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10544706", "map_id": "none", "name": "Gt-GTP dissociates to GNAT1-GTP and GNB1:GNGT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_2514888", "compartment_display": "photoreceptor disc membrane" }, { "id": "species_10544704", "map_id": "none", "name": "Gt-GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_2514888", "compartment_display": "photoreceptor disc membrane", "complex": "true" }, { "id": "species_10544702", "map_id": "none", "name": "GNB1:GNGT1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_2514888", "compartment_display": "photoreceptor disc membrane", "complex": "true" }, { "id": "species_10544695", "map_id": "none", "name": "GNAT1-GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_2514888", "compartment_display": "photoreceptor disc membrane", "complex": "true" }, { "id": "reaction_10544724", "map_id": "none", "name": "cGMP dissociates from CNG channels", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10506568", "map_id": "none", "name": "cGMP:CNG channel", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "G5EEE2", "map_id": "G5EEE2", "name": "tax-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006525", "map_id": "WBGene00006525", "name": "tax-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q03611", "map_id": "Q03611", "name": "tax-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006526", "map_id": "WBGene00006526", "name": "tax-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7Z205", "map_id": "Q7Z205", "name": "cng-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000563", "map_id": "WBGene00000563", "name": "cng-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A8WI01", "map_id": "A8WI01", "name": "cng-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000562", "map_id": "WBGene00000562", "name": "cng-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9N4C1", "map_id": "Q9N4C1", "name": "cng-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022295", "map_id": "WBGene00022295", "name": "cng-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O61827", "map_id": "O61827", "name": "che-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000487", "map_id": "WBGene00000487", "name": "che-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_30991", "map_id": "CHEBI:16356", "name": "cGMP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10506566", "map_id": "none", "name": "CNG channel", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10544727", "map_id": "none", "name": "cGMP:CNG transports Na+ and Ca2+ into the rod outer segment", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10544802", "map_id": "none", "name": "NMT1/2 transfer MYS to GNAT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10544792", "map_id": "none", "name": "Homologues of GNAT1 (Met removed)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_2534019", "map_id": "CHEBI:15532", "name": "MYS-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10544691", "map_id": "none", "name": "Homologues of N-(C14:0)-GNAT1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_2514888", "compartment_display": "photoreceptor disc membrane", "complex": "true" }, { "id": "species_10544797", "map_id": "P46548", "name": "nmt-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00020549", "map_id": "WBGene00020549", "name": "nmt-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10544837", "map_id": "none", "name": "METAP1/2 demethylates GNAT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10544818", "map_id": "none", "name": "Homologues of GNAT1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10544834", "map_id": "none", "name": "METAP1/2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_880069", "map_id": "CHEBI:27638", "name": "Co2+", "type": "catalyst", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "H1UBK1", "map_id": "H1UBK1", "name": "map-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003130", "map_id": "WBGene00003130", "name": "map-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q965Y1", "map_id": "Q965Y1", "name": "map-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003129", "map_id": "WBGene00003129", "name": "map-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10544774", "map_id": "none", "name": "FNTA:FNTB transfers FARN to GNGT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_2514888", "compartment_display": "photoreceptor disc membrane" }, { "id": "species_10544764", "map_id": "P54406", "name": "gpc-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_2514888", "compartment_display": "photoreceptor disc membrane", "complex": "false" }, { "id": "species_2530486", "map_id": "CHEBI:50277", "name": "FPP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10544700", "map_id": "P54406", "name": "gpc-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_2514888", "compartment_display": "photoreceptor disc membrane", "complex": "false" }, { "id": "species_10544771", "map_id": "none", "name": "FNTA:FNTB", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q19752", "map_id": "Q19752", "name": "fntb-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006465", "map_id": "WBGene00006465", "name": "fntb-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O44501", "map_id": "O44501", "name": "fnta-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019823", "map_id": "WBGene00019823", "name": "fnta-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10544918", "map_id": "none", "name": "GUCA binds Ca2+ to form GUCA:Ca2+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10544904", "map_id": "P36609", "name": "ncs-2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_2514888", "compartment_display": "photoreceptor disc membrane", "complex": "false" }, { "id": "species_10544916", "map_id": "none", "name": "GUCA:Ca2+", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_2514888", "compartment_display": "photoreceptor disc membrane", "complex": "true" }, { "id": "reaction_10546711", "map_id": "none", "name": "CALM1:Ca2+ binds CNG channel", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10546709", "map_id": "none", "name": "CALM1:Ca2+:CNG channel", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10506570", "map_id": "none", "name": "cGMP binds CNG channel to form cGMP:CNG channel", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10544161", "map_id": "none", "name": "atROL binds RBP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_2473616", "map_id": "CHEBI:17336", "name": "atROL", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10506914", "map_id": "none", "name": "Homologues of RBP1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "O02324", "map_id": "O02324", "name": "lbp-8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002260", "map_id": "WBGene00002260", "name": "lbp-8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O01812", "map_id": "O01812", "name": "lbp-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002258", "map_id": "WBGene00002258", "name": "lbp-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O01814", "map_id": "O01814", "name": "lbp-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002257", "map_id": "WBGene00002257", "name": "lbp-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O02323", "map_id": "O02323", "name": "lbp-7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002259", "map_id": "WBGene00002259", "name": "lbp-7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10544159", "map_id": "none", "name": "RBP1:atROL", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_5623649", "map_id": "CHEBI:17336", "name": "atROL", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "false" }, { "id": "reaction_10544130", "map_id": "none", "name": "atRAL binds to RBP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10530542", "map_id": "none", "name": "Homologues of RBP2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_975622", "map_id": "CHEBI:17898", "name": "atRAL", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10530546", "map_id": "none", "name": "RBP2:atRAL", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_5623648", "map_id": "CHEBI:17898", "name": "atRAL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "false" }, { "id": "reaction_10530532", "map_id": "none", "name": "PLB1 hydrolyses RPALM to atROL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_975591", "map_id": "CHEBI:17616", "name": "RPALM", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_975590", "map_id": "CHEBI:17336", "name": "atROL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_426576", "map_id": "CHEBI:15756", "name": "PALM", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10530529", "map_id": "none", "name": "Homologues of PLB1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q8MXQ8", "map_id": "Q8MXQ8", "name": "PLB1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022256", "map_id": "WBGene00022256", "name": "PLB1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9N2Z4", "map_id": "Q9N2Z4", "name": "PLB1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10530548", "map_id": "none", "name": "atROL binds to RBP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10530544", "map_id": "none", "name": "RBP2:atROL", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10544165", "map_id": "none", "name": "Parenchymal atROL translocates to HSCs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10544163", "map_id": "none", "name": "RBP1:atROL", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10530570", "map_id": "none", "name": "BCMO1:Fe2+ cleaves betaC to atRAL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_975643", "map_id": "CHEBI:17579", "name": "betaC", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10530567", "map_id": "none", "name": "BCMO1:Fe2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9U2E4", "map_id": "Q9U2E4", "name": "bcmo-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012914", "map_id": "WBGene00012914", "name": "bcmo-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "H2L060", "map_id": "H2L060", "name": "BCMO1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018640", "map_id": "WBGene00018640", "name": "BCMO1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9TXT9", "map_id": "Q9TXT9", "name": "bcmo-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018755", "map_id": "WBGene00018755", "name": "bcmo-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10545931", "map_id": "none", "name": "AKRs reduce RBP2:atRAL to RBP2:atROL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10545928", "map_id": "none", "name": "AKRs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P91020", "map_id": "P91020", "name": "AKR1B10", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016985", "map_id": "WBGene00016985", "name": "AKR1B10", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q18903", "map_id": "Q18903", "name": "AKR1B10", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q23320", "map_id": "Q23320", "name": "AKR1B10", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10544155", "map_id": "none", "name": "RBP4:atROL binds TTR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10544137", "map_id": "none", "name": "RBP4:atROL", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "G5EEB8", "map_id": "G5EEB8", "name": "lpr-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011726", "map_id": "WBGene00011726", "name": "lpr-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10544151", "map_id": "none", "name": "TTR tetramer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "Q21882", "map_id": "Q21882", "name": "TTR", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022808", "map_id": "WBGene00022808", "name": "TTR", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O44578", "map_id": "O44578", "name": "TTR", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10544153", "map_id": "none", "name": "TTR:RBP4:atROL", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10545933", "map_id": "none", "name": "atROL binds RBP1 (parenchymal cell)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_2473610", "map_id": "CHEBI:17336", "name": "atROL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10544157", "map_id": "none", "name": "RBP4 binds atROL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10544135", "map_id": "G5EEB8", "name": "lpr-2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_2395761", "map_id": "CHEBI:17336", "name": "atROL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10550030", "map_id": "none", "name": "BCO2:Fe2+ cleaves betaC to APO10al and bION", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_5164389", "map_id": "CHEBI:17579", "name": "betaC", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_5164390", "map_id": "CHEBI:32325", "name": "bION", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_5164383", "map_id": "CHEBI:53153", "name": "APO10al", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10550027", "map_id": "none", "name": "BCO2:Fe2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "reaction_10544304", "map_id": "none", "name": "RDH12 reduces atRAL to atROL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_2473615", "map_id": "CHEBI:17336", "name": "atROL", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10544301", "map_id": "Q93291", "name": "RDH12", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_2473609", "compartment_display": "photoreceptor inner segment membrane", "complex": "false" }, { "id": "WBGene00007780", "map_id": "WBGene00007780", "name": "RDH12", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10506918", "map_id": "none", "name": "atROL binds RBP1 to form RBP1:atROL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_2473604", "map_id": "CHEBI:17336", "name": "atROL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10506916", "map_id": "none", "name": "RBP1:atROL", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10544295", "map_id": "none", "name": "RPE65 isomero-hydrolyses atREs to 11cROL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_2864099", "map_id": "none", "name": "atREs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_13977", "compartment_display": "lipid droplet", "complex": "true" }, { "id": "CHEBI:70762", "map_id": "CHEBI:70762", "name": "CHEBI:70762", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_2534407", "map_id": "CHEBI:17616", "name": "atR-PALM", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "CHEBI:70760", "map_id": "CHEBI:70760", "name": "CHEBI:70760", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:70761", "map_id": "CHEBI:70761", "name": "CHEBI:70761", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_30927", "map_id": "CHEBI:16302", "name": "11cROL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_2864103", "map_id": "none", "name": "FAs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_13977", "compartment_display": "lipid droplet", "complex": "true" }, { "id": "CHEBI:17351", "map_id": "CHEBI:17351", "name": "CHEBI:17351", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10544287", "map_id": "none", "name": "Homologues of RPE65", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10544293", "map_id": "P91443", "name": "hum-6", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00002039", "map_id": "WBGene00002039", "name": "hum-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10544339", "map_id": "none", "name": "atRAL is reduced to atROL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_2473607", "map_id": "CHEBI:17336", "name": "atROL", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10544336", "map_id": "none", "name": "Homologues of DHRS3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_74000", "compartment_display": "photoreceptor outer segment membrane", "complex": "true" }, { "id": "O18030", "map_id": "O18030", "name": "dhs-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000968", "map_id": "WBGene00000968", "name": "dhs-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q19843", "map_id": "Q19843", "name": "dhs-29", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000992", "map_id": "WBGene00000992", "name": "dhs-29", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q22392", "map_id": "Q22392", "name": "dhs-19", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000982", "map_id": "WBGene00000982", "name": "dhs-19", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A5JYX5", "map_id": "A5JYX5", "name": "dhs-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000967", "map_id": "WBGene00000967", "name": "dhs-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10543792", "map_id": "none", "name": "CDK1 phosphorylates condensin II subunit NCAPD3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10543756", "map_id": "none", "name": "Condensin II:Nucleosome with H4K20me1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q20818", "map_id": "Q20818", "name": "phospho-capg-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010093", "map_id": "WBGene00010093", "name": "phospho-capg-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q09591", "map_id": "Q09591", "name": "mix-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003367", "map_id": "WBGene00003367", "name": "mix-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34341", "map_id": "P34341", "name": "phospho-kle-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016202", "map_id": "WBGene00016202", "name": "phospho-kle-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q20060", "map_id": "Q20060", "name": "smc-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004874", "map_id": "WBGene00004874", "name": "smc-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q95Y84", "map_id": "Q95Y84", "name": "phospho-hcp-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001833", "map_id": "WBGene00001833", "name": "phospho-hcp-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10543788", "map_id": "none", "name": "Phosphorylated Condensin II:Nucleosome", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10543762", "map_id": "none", "name": "Condensin II complex binds H4K20me1-containing nucleosomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10543339", "map_id": "none", "name": "Condensin II", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10543368", "map_id": "none", "name": "Nucleosome with H3K4me2/3:H4K20me1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10543760", "map_id": "none", "name": "Condensin II:RB1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10543715", "map_id": "none", "name": "CDK1 phosphorylates PHF8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10543378", "map_id": "none", "name": "PHF8:Nucleosome with H3K4me2/3:H4K20me1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10543713", "map_id": "none", "name": "p-2S-PHF8:Fe2+", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10543385", "map_id": "none", "name": "PHF8 demethylates histone H4K20me1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10543382", "map_id": "none", "name": "PHF8:Nucleosome with H3K4me2/3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10543786", "map_id": "none", "name": "PLK1 hyperphosphorylates Condensin II complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10543770", "map_id": "none", "name": "p-T210-PLK1:Phosphorylated Condensin II:Nucleosome", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9N2L7", "map_id": "Q9N2L7", "name": "phospho-plk-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004043", "map_id": "WBGene00004043", "name": "phospho-plk-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10543783", "map_id": "none", "name": "Hyperphosphorylated Condensin II:Nucleosome", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10543804", "map_id": "none", "name": "SETD8 monomethylates histone H4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10543790", "map_id": "none", "name": "PLK1 binds phosphorylated condensin II complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10509851", "map_id": "Q9N2L7", "name": "phospho-plk-2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10543577", "map_id": "none", "name": "PLK1 phosphorylates GORASP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10543569", "map_id": "none", "name": "p-T216,S274,S373-GORASP1:p-S37-GOLGA2:p-RAB1:GTP:p-T210-PLK1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "species_10543574", "map_id": "none", "name": "p-T216,S189,S274,S373-GORASP1:p-S37-GOLGA2:p-RAB1:GTP:p-T210-PLK1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "reaction_10544207", "map_id": "none", "name": "MAPK3-3 or MAPK1 phosphorylate GORASP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10544192", "map_id": "none", "name": "GORASP2:BLZF1:RAB2A:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "Q21954", "map_id": "Q21954", "name": "BLZF1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020018", "map_id": "WBGene00020018", "name": "BLZF1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A2C9C2Y0", "map_id": "A0A2C9C2Y0", "name": "unc-108", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006833", "map_id": "WBGene00006833", "name": "unc-108", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10544198", "map_id": "none", "name": "p-T222,225-GORASP2:BLZF1:RAB2A:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "species_10544204", "map_id": "none", "name": "p-Y204-MAPK3-3/p-T185,Y187-MAPK1 homodimer", "type": "catalyst", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10514372", "map_id": "none", "name": "AKT can phosphorylate RSK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10514366", "map_id": "Q9NAH6", "name": "rsks-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00012929", "map_id": "WBGene00012929", "name": "phospho-rsks-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10514370", "map_id": "Q9NAH6", "name": "phospho-rsks-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10514300", "map_id": "none", "name": "AKT phosphorylates FOXO transcription factors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10514274", "map_id": "O16850", "name": "daf-16", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10514285", "map_id": "O16850", "name": "phospho-daf-16", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10514269", "map_id": "none", "name": "AKT phosphorylates CREB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10514382", "map_id": "none", "name": "AKT can phosphorylate NR4A1 (NUR77)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10514377", "map_id": "P41829", "name": "nhr-6", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00003605", "map_id": "WBGene00003605", "name": "phospho-nhr-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10514380", "map_id": "P41829", "name": "phospho-nhr-6", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10571544", "map_id": "none", "name": "CYPs hydroxylate DHA to 14(R)-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9024011", "map_id": "CHEBI:28125", "name": "DHA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_9027049", "map_id": "CHEBI:137346", "name": "14(R)-HDHA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10507820", "map_id": "none", "name": "Homologues of CYP2D6", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10523346", "map_id": "none", "name": "P2Y purinoceptor 1 activates MAP kinase p38 alpha", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10523344", "map_id": "Q17446", "name": "pmk-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10512654", "map_id": "Q17446", "name": "phospho-pmk-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10521881", "map_id": "none", "name": "Src activation following P2Y purinoceptor activation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10518252", "map_id": "none", "name": "Homologues of p-Y419-SRC", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10556833", "map_id": "none", "name": "PSMD14 cleaves K63-linked ubiquitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10511035", "map_id": "none", "name": "K63polyUb", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10511033", "map_id": "none", "name": "K63-Ub", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10502380", "map_id": "O76577", "name": "rpn-11", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10556830", "map_id": "none", "name": "MYSM1 deubiquitinates Histone H2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10556825", "map_id": "none", "name": "MYSM1:EP300:KAT2B:Ub-histone H2A", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "P34545", "map_id": "P34545", "name": "cbp-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9N3S7", "map_id": "Q9N3S7", "name": "pcaf-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021636", "map_id": "WBGene00021636", "name": "pcaf-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10556827", "map_id": "none", "name": "MYSM1:EP300:KAT2B:Histone H2A", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10511057", "map_id": "none", "name": "Reducing equivalents from beta-oxidation of fatty acids transfer to ETF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10511052", "map_id": "none", "name": "ETF:FAD", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q93615", "map_id": "Q93615", "name": "Q93615", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009187", "map_id": "WBGene00009187", "name": "Q93615", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9TXI4", "map_id": "Q9TXI4", "name": "Me3K200,Me3K203-ETFB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017734", "map_id": "WBGene00017734", "name": "Me3K200,Me3K203-ETFB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_31649", "map_id": "CHEBI:17877", "name": "FADH2", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10511054", "map_id": "none", "name": "ETF:FADH2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "reaction_10511065", "map_id": "none", "name": "ETFDH oxidises ETF (reduced) to ETF, reduces CoQ to QH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_73663", "map_id": "CHEBI:46245", "name": "CoQ", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "species_76633", "map_id": "CHEBI:17976", "name": "QH2", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "species_10511062", "map_id": "Q11190", "name": "let-721", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "WBGene00002855", "map_id": "WBGene00002855", "name": "let-721", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10562852", "map_id": "none", "name": "NDUF subunits bind to form the IP subcomplex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10561725", "map_id": "Q86NC2", "name": "nuo-2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "WBGene00020417", "map_id": "WBGene00020417", "name": "nuo-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10561709", "map_id": "none", "name": "NDUFAF7:NDUFS2:2x4Fe-4S", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q93873", "map_id": "Q93873", "name": "gas-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001520", "map_id": "WBGene00001520", "name": "gas-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q09644", "map_id": "Q09644", "name": "NDUFAF7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00014227", "map_id": "WBGene00014227", "name": "NDUFAF7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10561720", "map_id": "none", "name": "NDUFS8:2x4Fe-4S", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q22619", "map_id": "Q22619", "name": "NDUFS8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020636", "map_id": "WBGene00020636", "name": "NDUFS8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10561718", "map_id": "none", "name": "NDUFS7:4Fe-4S", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q94360", "map_id": "Q94360", "name": "nduf-7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012376", "map_id": "WBGene00012376", "name": "nduf-7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10561716", "map_id": "none", "name": "NDUFA9:FAD", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q9N3H3", "map_id": "Q9N3H3", "name": "nduf-9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021800", "map_id": "WBGene00021800", "name": "nduf-9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10561727", "map_id": "none", "name": "IP subcomplex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q86NC2", "map_id": "Q86NC2", "name": "nuo-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10561780", "map_id": "none", "name": "IP subcomplex binds NDUFAF3, NDUFAF4, TIMMDC1 to form Intermediate 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10561742", "map_id": "I2HAE1", "name": "TIMMDC1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "WBGene00021421", "map_id": "WBGene00021421", "name": "TIMMDC1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10561737", "map_id": "Q17439", "name": "NDUFAF4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "WBGene00007113", "map_id": "WBGene00007113", "name": "NDUFAF4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10561732", "map_id": "Q93931", "name": "nuaf-3", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "WBGene00011123", "map_id": "WBGene00011123", "name": "nuaf-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10561744", "map_id": "none", "name": "Intermediate 1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "Q93931", "map_id": "Q93931", "name": "nuaf-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q17439", "map_id": "Q17439", "name": "NDUFAF4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "I2HAE1", "map_id": "I2HAE1", "name": "TIMMDC1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10561748", "map_id": "none", "name": "Intermediate 1 binds HP subcomplex to form Intermediate 2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane" }, { "id": "species_10561700", "map_id": "none", "name": "HP subcomplex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "Q20412", "map_id": "Q20412", "name": "NDUFB2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009712", "map_id": "WBGene00009712", "name": "NDUFB2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q18359", "map_id": "Q18359", "name": "NDUFA5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007880", "map_id": "WBGene00007880", "name": "NDUFA5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q93831", "map_id": "Q93831", "name": "NDUFB10", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010326", "map_id": "WBGene00010326", "name": "NDUFB10", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q18095", "map_id": "Q18095", "name": "NDUFB3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007684", "map_id": "WBGene00007684", "name": "NDUFB3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9BL33", "map_id": "Q9BL33", "name": "NDUFC2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022169", "map_id": "WBGene00022169", "name": "NDUFC2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XWG2", "map_id": "Q9XWG2", "name": "NDUFA2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013406", "map_id": "WBGene00013406", "name": "NDUFA2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q23098", "map_id": "Q23098", "name": "nuo-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012166", "map_id": "WBGene00012166", "name": "nuo-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O44955", "map_id": "O44955", "name": "NDUFA13", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016393", "map_id": "WBGene00016393", "name": "NDUFA13", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "H2KYV1", "map_id": "H2KYV1", "name": "NDUFB5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016118", "map_id": "WBGene00016118", "name": "NDUFB5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O18236", "map_id": "O18236", "name": "nuo-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013308", "map_id": "WBGene00013308", "name": "nuo-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9U241", "map_id": "Q9U241", "name": "NDUFAB1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013237", "map_id": "WBGene00013237", "name": "NDUFAB1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P90789", "map_id": "P90789", "name": "NDUFB7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008414", "map_id": "WBGene00008414", "name": "NDUFB7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O44509", "map_id": "O44509", "name": "NDUFB11", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018361", "map_id": "WBGene00018361", "name": "NDUFB11", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O02267", "map_id": "O02267", "name": "NDUFA7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009740", "map_id": "WBGene00009740", "name": "NDUFA7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q21233", "map_id": "Q21233", "name": "nuo-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019401", "map_id": "WBGene00019401", "name": "nuo-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9BL03", "map_id": "Q9BL03", "name": "NDUFA8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021849", "map_id": "WBGene00021849", "name": "NDUFA8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q18036", "map_id": "Q18036", "name": "NDUFB9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00015810", "map_id": "WBGene00015810", "name": "NDUFB9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10561746", "map_id": "none", "name": "Intermediate 2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "reaction_10521531", "map_id": "none", "name": "PPARA binds RXRA forming PPARA:RXRA heterodimer at promoter of target gene", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10514477", "map_id": "Q9U2R6", "name": "nhr-91", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00003681", "map_id": "WBGene00003681", "name": "nhr-91", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_422139", "map_id": "none", "name": "Peroxisome Proliferator Receptor Element (PPRE)", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10519403", "map_id": "none", "name": "Homologues of PPARA", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "P41830", "map_id": "P41830", "name": "sex-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004786", "map_id": "WBGene00004786", "name": "sex-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q10902", "map_id": "Q10902", "name": "nhr-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003601", "map_id": "WBGene00003601", "name": "nhr-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q20765", "map_id": "Q20765", "name": "nhr-7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003606", "map_id": "WBGene00003606", "name": "nhr-7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XUK7", "map_id": "Q9XUK7", "name": "nhr-85", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003675", "map_id": "WBGene00003675", "name": "nhr-85", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10521529", "map_id": "none", "name": "PPARA:RXRA heterodimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9U2R6", "map_id": "Q9U2R6", "name": "nhr-91", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10542707", "map_id": "none", "name": "Duplex miRNA is loaded into Argonaute", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10542705", "map_id": "none", "name": "TARBP2,PRKRA RLC:duplex miRNA", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P34529", "map_id": "P34529", "name": "dcr-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000939", "map_id": "WBGene00000939", "name": "dcr-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EBF5", "map_id": "G5EBF5", "name": "rde-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004326", "map_id": "WBGene00004326", "name": "rde-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EES3", "map_id": "G5EES3", "name": "alg-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000105", "map_id": "WBGene00000105", "name": "alg-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10516856", "map_id": "none", "name": "TARBP2,PRKRA:DICER1:Pre-RISC (miRNA)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10516876", "map_id": "none", "name": "Removal of miRNA passenger strand", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10516874", "map_id": "none", "name": "TARBP2,PRKRA:DICER1:RISC (miRNA)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10567937", "map_id": "none", "name": "N6AMT2 transfers 3xCH3 from 3xAdoMet to EEF1A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10567929", "map_id": "P53013", "name": "eft-4", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10567934", "map_id": "Q5WRN3", "name": "N6AMT2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00043057", "map_id": "WBGene00043057", "name": "N6AMT2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10568005", "map_id": "none", "name": "METTL10 transfers 3xCH3 from 3xAdoMet to EEF1A1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10567997", "map_id": "P53013", "name": "eft-4", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10568002", "map_id": "Q9GYH9", "name": "METTL10", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00017919", "map_id": "WBGene00017919", "name": "METTL10", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10567926", "map_id": "none", "name": "ETFBKMT transfers 3xCH3 from 3xAdoMet to ETFB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10511050", "map_id": "Q9TXI4", "name": "ETFB", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_2162265", "map_id": "CHEBI:15414", "name": "AdoMet", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10567918", "map_id": "Q9TXI4", "name": "Me3K200,Me3K203-ETFB", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_2162252", "map_id": "CHEBI:16680", "name": "AdoHcy", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10567923", "map_id": "O01503", "name": "ETFBKMT", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "WBGene00016492", "map_id": "WBGene00016492", "name": "ETFBKMT", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10567962", "map_id": "none", "name": "VCPKMT (METTL21D) transfers 3xCH3 from 3xAdoMet to VCP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10551284", "map_id": "P54812", "name": "cdc-48.2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10567954", "map_id": "P54812", "name": "cdc-48.2", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10567959", "map_id": "A7IQW5", "name": "VCPKMT", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00016591", "map_id": "WBGene00016591", "name": "VCPKMT", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10523164", "map_id": "none", "name": "ROBO3.1 antagonizes ROBO1/ROBO2 to allow floor plate crossing", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10523160", "map_id": "Q53U87", "name": "sax-7", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "WBGene00004732", "map_id": "WBGene00004732", "name": "sax-7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10523158", "map_id": "none", "name": "Homologues of ROBO3.1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "H2KZ60", "map_id": "H2KZ60", "name": "rig-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016354", "map_id": "WBGene00016354", "name": "rig-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q18806", "map_id": "Q18806", "name": "rig-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004370", "map_id": "WBGene00004370", "name": "rig-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10523162", "map_id": "none", "name": "ROBO2,(ROBO1):ROBO3.1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q53U87", "map_id": "Q53U87", "name": "sax-7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10568768", "map_id": "none", "name": "Association of procollagen type XXIV", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_10539093", "map_id": "Q21437", "name": "col-84", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "WBGene00000659", "map_id": "WBGene00000659", "name": "col-84", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10540952", "map_id": "none", "name": "C-linked procollagen type XXIV trimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "Q21437", "map_id": "Q21437", "name": "col-84", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10568770", "map_id": "none", "name": "Association of procollagen type XIII", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_10540942", "map_id": "none", "name": "Alpha-1(XIII) chains", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "species_10540944", "map_id": "none", "name": "C-linked procollagen type XIII trimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "reaction_10568772", "map_id": "none", "name": "Association of procollagen type X", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_10540932", "map_id": "none", "name": "Alpha-1(X) chains", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "species_10540934", "map_id": "none", "name": "C-linked procollagen type X trimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "reaction_10568774", "map_id": "none", "name": "Association of procollagen type II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_10540908", "map_id": "none", "name": "Alpha-1(II) propeptides", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "species_10540910", "map_id": "none", "name": "C-linked procollagen type II trimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "reaction_10539495", "map_id": "none", "name": "Association of procollagen type XVIII", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_10539097", "map_id": "Q21437", "name": "col-84", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10539493", "map_id": "none", "name": "C-linked procollagen type XXVIII trimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "reaction_10568776", "map_id": "none", "name": "Association of procollagen type XI", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_10540938", "map_id": "none", "name": "Alpha-2(XI) propeptides", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "species_10540936", "map_id": "none", "name": "Alpha-1(XI) propeptides", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "species_10540940", "map_id": "none", "name": "C-linked procollagen type XI trimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "reaction_10568754", "map_id": "none", "name": "Association of procollagen type I", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_10536687", "map_id": "Q9N4U2", "name": "col-71", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10539099", "map_id": "Q9N4U2", "name": "col-71", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10540906", "map_id": "none", "name": "C-linked procollagen type I trimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "reaction_10568756", "map_id": "none", "name": "Association of procollagen type VIII", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_10539063", "map_id": "O17641", "name": "col-178", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10540928", "map_id": "none", "name": "Alpha-2(VIII) chains", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "species_10540930", "map_id": "none", "name": "C-linked procollagen type VIII trimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "reaction_10568758", "map_id": "none", "name": "Association of procollagen type V", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_10540920", "map_id": "none", "name": "Alpha-3(V) propeptides", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "species_10539061", "map_id": "P17140", "name": "let-2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10540916", "map_id": "none", "name": "Alpha-2(V) propeptides", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "species_10540926", "map_id": "none", "name": "C-linked procollagen type V trimers", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "reaction_10568762", "map_id": "none", "name": "Association of procollagen type XIX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_10540948", "map_id": "none", "name": "Alpha-1(XIX) chains", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "species_10540950", "map_id": "none", "name": "C-linked procollagen type XIX trimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "reaction_10568764", "map_id": "none", "name": "Association of procollagen type III", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_10540912", "map_id": "none", "name": "Alpha-1(III) propeptides", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "species_10540914", "map_id": "none", "name": "C-linked procollagen type III trimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "reaction_10568766", "map_id": "none", "name": "Association of procollagen type XXVII", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_10539095", "map_id": "P17140", "name": "let-2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10540954", "map_id": "none", "name": "C-linked procollagen type XXVII trimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "reaction_10512308", "map_id": "none", "name": "Phosphorylation of CBL (EGFR:GRB2:CBL)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10512305", "map_id": "none", "name": "EGF-like ligands:p-6Y-EGFR:CBL:GRB2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10512272", "map_id": "none", "name": "EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10566342", "map_id": "none", "name": "EGFR phosphorylates EPS15", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10566337", "map_id": "none", "name": "EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:EPS15:HGS:STAM", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9BIF4", "map_id": "Q9BIF4", "name": "phospho-ehs-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001224", "map_id": "WBGene00001224", "name": "phospho-ehs-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q18453", "map_id": "Q18453", "name": "rsd-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004682", "map_id": "WBGene00004682", "name": "rsd-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9BI71", "map_id": "Q9BI71", "name": "epn-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001329", "map_id": "WBGene00001329", "name": "epn-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q17796", "map_id": "Q17796", "name": "hgrs-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004101", "map_id": "WBGene00004101", "name": "hgrs-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O01498", "map_id": "O01498", "name": "stam-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004109", "map_id": "WBGene00004109", "name": "stam-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10566339", "map_id": "none", "name": "EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:p-EPS15:HGS:STAM", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10512298", "map_id": "none", "name": "Ubiquitination of stimulated EGFR (CBL:GRB2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10512290", "map_id": "none", "name": "EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10512296", "map_id": "G5EC69", "name": "PTPRK", "type": "inhibitor", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "WBGene00011755", "map_id": "WBGene00011755", "name": "PTPRU", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10512315", "map_id": "none", "name": "CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10512310", "map_id": "none", "name": "EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10512312", "map_id": "none", "name": "Ub-Beta-Pix:CDC42:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10512270", "map_id": "none", "name": "CBL-mediated ubiquitination of CIN85", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10512255", "map_id": "none", "name": "EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15L1:Eps15", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10512265", "map_id": "none", "name": "EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:Ub-CIN85:Endophilin:Epsin:Eps15L1:Eps15", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10512303", "map_id": "none", "name": "CBL binds to GRB2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10512301", "map_id": "none", "name": "CBL:GRB2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10512319", "map_id": "none", "name": "CDC42:GTP binds CBL:Beta-Pix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10512286", "map_id": "none", "name": "Beta-Pix:CDC42:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10512317", "map_id": "none", "name": "CBL:Beta-Pix:CDC42:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10566350", "map_id": "none", "name": "PTPN3 dephosphorylates EPS15", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10566347", "map_id": "P28191", "name": "ptp-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "WBGene00004213", "map_id": "WBGene00004213", "name": "ptp-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10541063", "map_id": "none", "name": "Cathepsin Z (Cathepsin X) hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10541036", "map_id": "none", "name": "Homologues of AGT(34-43)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10528011", "map_id": "none", "name": "Homologues of AGT(34-41)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10541060", "map_id": "none", "name": "Homologues of CTSZ", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9XWA4", "map_id": "Q9XWA4", "name": "(Glc)3(GlcNAc)2(Man)9-CTSZ", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013764", "map_id": "WBGene00013764", "name": "(Glc)3(GlcNAc)2(Man)9-CTSZ", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XXQ7", "map_id": "Q9XXQ7", "name": "(Glc)3(GlcNAc)2(Man)9-CTSZ", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EGP8", "map_id": "G5EGP8", "name": "cpz-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000788", "map_id": "WBGene00000788", "name": "cpz-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P92005", "map_id": "P92005", "name": "cpz-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000789", "map_id": "WBGene00000789", "name": "cpz-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q18740", "map_id": "Q18740", "name": "tag-329", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008231", "map_id": "WBGene00008231", "name": "tag-329", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9U2X1", "map_id": "Q9U2X1", "name": "(Glc)3(GlcNAc)2(Man)9-CTSZ", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10541193", "map_id": "none", "name": "Renin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10541102", "map_id": "none", "name": "Homologues of AGT", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10541190", "map_id": "none", "name": "Renin:Prorenin Receptor", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9XTY9", "map_id": "Q9XTY9", "name": "vha-20", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010993", "map_id": "WBGene00010993", "name": "vha-20", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O01530", "map_id": "O01530", "name": "asp-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000219", "map_id": "WBGene00000219", "name": "asp-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q22972", "map_id": "Q22972", "name": "asp-13", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017881", "map_id": "WBGene00017881", "name": "asp-13", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O01531", "map_id": "O01531", "name": "asp-12", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017678", "map_id": "WBGene00017678", "name": "asp-12", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7JKL9", "map_id": "Q7JKL9", "name": "asp-18", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013973", "map_id": "WBGene00013973", "name": "asp-18", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O01532", "map_id": "O01532", "name": "asp-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000218", "map_id": "WBGene00000218", "name": "asp-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86NE0", "map_id": "Q86NE0", "name": "asp-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000215", "map_id": "WBGene00000215", "name": "asp-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O45072", "map_id": "O45072", "name": "asp-9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00015700", "map_id": "WBGene00015700", "name": "asp-9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8MYN5", "map_id": "Q8MYN5", "name": "asp-17", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012683", "map_id": "WBGene00012683", "name": "asp-17", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P55956", "map_id": "P55956", "name": "asp-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000216", "map_id": "WBGene00000216", "name": "asp-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EC01", "map_id": "G5EC01", "name": "asp-19", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00077655", "map_id": "WBGene00077655", "name": "asp-19", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8MYN6", "map_id": "Q8MYN6", "name": "asp-16", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012682", "map_id": "WBGene00012682", "name": "asp-16", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q18020", "map_id": "Q18020", "name": "hrg-7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007605", "map_id": "WBGene00007605", "name": "hrg-7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EEI4", "map_id": "G5EEI4", "name": "asp-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000214", "map_id": "WBGene00000214", "name": "asp-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8MYN7", "map_id": "Q8MYN7", "name": "asp-15", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012681", "map_id": "WBGene00012681", "name": "asp-15", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_2022362", "map_id": "CHEBI:601027", "name": "aliskiren", "type": "inhibitor", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10541065", "map_id": "none", "name": "Neprilysin hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-7)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10541012", "map_id": "none", "name": "Homologues of AGT(34-40)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10541017", "map_id": "Q18673", "name": "nep-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "WBGene00013926", "map_id": "WBGene00013926", "name": "nep-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10541930", "map_id": "none", "name": "Mast Cell Carboxypeptidase hydrolyzes Angiotensin-(1-10) to Yield Angiotensin-(1-9)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10540996", "map_id": "none", "name": "Homologues of AGT(34-42)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10541927", "map_id": "none", "name": "Carboxypeptidase", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "Q9BL88", "map_id": "Q9BL88", "name": "CPB2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021984", "map_id": "WBGene00021984", "name": "CPB2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "H2L0D7", "map_id": "H2L0D7", "name": "CPB2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G3MU29", "map_id": "G3MU29", "name": "CPB2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9TZC6", "map_id": "Q9TZC6", "name": "CPB2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "H2L0K5", "map_id": "H2L0K5", "name": "CPB2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EC13", "map_id": "G5EC13", "name": "CPB2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XU75", "map_id": "Q9XU75", "name": "suro-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011235", "map_id": "WBGene00011235", "name": "suro-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q6A577", "map_id": "Q6A577", "name": "CPB2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EC96", "map_id": "G5EC96", "name": "CPB2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10541196", "map_id": "none", "name": "ACE hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10541067", "map_id": "Q18581", "name": "acn-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "WBGene00000039", "map_id": "WBGene00000039", "name": "acn-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10572173", "map_id": "none", "name": "ACEIs bind ACE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_9614913", "map_id": "none", "name": "ACEIs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10542353", "map_id": "Q18581", "name": "acn-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10542356", "map_id": "none", "name": "ACEIs:ACE(30-1232)", "type": "inhibitor", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "Q18581", "map_id": "Q18581", "name": "acn-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10541070", "map_id": "none", "name": "ACE hydrolyzes Angiotensin-(1-9) to Angiotensin-(1-7)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "reaction_10541235", "map_id": "none", "name": "Renin hydrolyzes Angiotensinogen to Angiotensin-(1-10)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10541232", "map_id": "none", "name": "Renin", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10541044", "map_id": "none", "name": "ACE2 hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-9)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10541041", "map_id": "Q18581", "name": "acn-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10542358", "map_id": "none", "name": "Secreted ACE hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "reaction_10541046", "map_id": "none", "name": "ACE2 hydrolyzes Angiotensin-(1-8) to Angiotensin-(1-7)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "reaction_10572216", "map_id": "none", "name": "CES1trimer hydrolyses ACEI pro-drugs to ACEIs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_9619052", "map_id": "none", "name": "ACEI pro-drugs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_8878776", "map_id": "CHEBI:30879", "name": "Alcohol", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_9619021", "map_id": "none", "name": "hydrolysed ACEIs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10557032", "map_id": "none", "name": "CES1 trimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "Q04457", "map_id": "Q04457", "name": "ges-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001578", "map_id": "WBGene00001578", "name": "ges-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10542396", "map_id": "none", "name": "Prorenin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10542393", "map_id": "none", "name": "Prorenin-Prorenin Receptor", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10541020", "map_id": "none", "name": "Neprilysin hydrolyzes Angiotensin-(1-9) to Angiotensin-(1-7)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "reaction_10549712", "map_id": "none", "name": "PIAS1,2-1 SUMOylate NR5A2 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10549685", "map_id": "none", "name": "NR5A2:cis-bicyclo(3.3.0)oct-2-ene", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "CHEBI:77361", "map_id": "CHEBI:77361", "name": "CHEBI:77361", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9N2W3", "map_id": "Q9N2W3", "name": "nhr-277", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022374", "map_id": "WBGene00022374", "name": "nhr-277", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q18190", "map_id": "Q18190", "name": "nhr-258", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016126", "map_id": "WBGene00016126", "name": "nhr-258", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XTJ4", "map_id": "Q9XTJ4", "name": "nhr-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003602", "map_id": "WBGene00003602", "name": "nhr-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q19345", "map_id": "Q19345", "name": "nhr-25", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003623", "map_id": "WBGene00003623", "name": "nhr-25", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q21104", "map_id": "Q21104", "name": "nhr-38", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003629", "map_id": "WBGene00003629", "name": "nhr-38", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10549707", "map_id": "none", "name": "SUMO1:NR5A2:cis-bicyclo(3.3.0)oct-2-ene", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10549709", "map_id": "none", "name": "PIAS1,2-1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10549218", "map_id": "none", "name": "PIAS1,3 SUMOylates NR5A1 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10519472", "map_id": "Q19345", "name": "nhr-25", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10549213", "map_id": "none", "name": "2SUMO1:NR5A1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10549215", "map_id": "none", "name": "PIAS1,3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10549683", "map_id": "none", "name": "SUMOylation of NR1H4 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10549672", "map_id": "none", "name": "NR1H4:chenodeoxycholate", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "G5ECR9", "map_id": "G5ECR9", "name": "unc-55", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006790", "map_id": "WBGene00006790", "name": "unc-55", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10549681", "map_id": "none", "name": "2SUMO1:NR1H4:chenodeoxycholate", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10549573", "map_id": "none", "name": "PIAS2-2 SUMOylates THRA with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10519457", "map_id": "none", "name": "Homologues of THRA", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10549571", "map_id": "none", "name": "2SUMO1:THRA-2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10548942", "map_id": "Q94361", "name": "gei-17", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10549096", "map_id": "none", "name": "SUMOylation of RXRA with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10549094", "map_id": "none", "name": "SUMO1:RXRA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10549548", "map_id": "none", "name": "PIAS2,3,4 SUMOylate RORA with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10519389", "map_id": "P41828", "name": "nhr-23", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00003622", "map_id": "WBGene00003622", "name": "nhr-23", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10549543", "map_id": "none", "name": "SUMO1:RORA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "P41828", "map_id": "P41828", "name": "nhr-23", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10549545", "map_id": "none", "name": "PIAS2-2,PIAS3,PIAS4", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10549117", "map_id": "none", "name": "PIAS4 SUMOylates PPARA with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10549115", "map_id": "none", "name": "SUMO1:PPARA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10546168", "map_id": "none", "name": "Homologues of PIAS4", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10549535", "map_id": "none", "name": "PIAS1 SUMOylates THRB with SUMO1.", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10519467", "map_id": "none", "name": "Homologues of THRB", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10549533", "map_id": "none", "name": "3SUMO1:THRB", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10554195", "map_id": "none", "name": "Oxidative damage to the AP site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10508796", "map_id": "none", "name": "APEX1:SSB(AP->5'-dRP)-dsDNA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10554193", "map_id": "none", "name": "APEX1:SSB(5'-ddRP)-dsDNA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10508799", "map_id": "none", "name": "APEX1 mediates endonucleolytic cleavage at the 5' side of the AP site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10508673", "map_id": "none", "name": "Cleavage of uracil by UNG glycosylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10508666", "map_id": "none", "name": "UNG-1:(Ura:Gua)-dsDNA", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_29554", "map_id": "CHEBI:17568", "name": "Ura", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10508689", "map_id": "none", "name": "Cleavage of thymine glycol by NTHL1 glycosylase ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10508684", "map_id": "none", "name": "NTHL1:Tg-dsDNA", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_110223", "map_id": "CHEBI:29128", "name": "Tg", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10508710", "map_id": "none", "name": "Cleavage of formamidopyrimidine (FapyA) by NTHL1 glycosylase ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10508707", "map_id": "none", "name": "NTHL1:FapyA-dsDNA", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_5637659", "map_id": "CHEBI:27983", "name": "FapyA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10508680", "map_id": "none", "name": "Cleavage of 5-hydroxyluracil by UNG glycosylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10508677", "map_id": "none", "name": "UNG-1:5-OHU-dsDNA", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_110216", "map_id": "CHEBI:29115", "name": "5-OHU", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10508696", "map_id": "none", "name": "Cleavage of cytosine glycol by NTHL1 glycosylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10508693", "map_id": "none", "name": "NTHL1:Cg-dsDNA", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_110225", "map_id": "CHEBI:29127", "name": "Cg", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10508703", "map_id": "none", "name": "Cleavage of dihydrouracil by NTHL1 glycosylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10508700", "map_id": "none", "name": "NTHL1:DHU-dsDNA", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_30140", "map_id": "CHEBI:15901", "name": "DHU", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10507554", "map_id": "none", "name": "Conversion of Glycerol to Glycerol-3-phosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_76114", "map_id": "CHEBI:15978", "name": "G3P", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10507551", "map_id": "none", "name": "GK,GK2,GK3P", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q21944", "map_id": "Q21944", "name": "GK", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020007", "map_id": "WBGene00020007", "name": "GK", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10507603", "map_id": "none", "name": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_75967", "map_id": "CHEBI:37554", "name": "FACoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_76103", "map_id": "CHEBI:17815", "name": "DAG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_549167", "map_id": "CHEBI:17855", "name": "TAG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10507600", "map_id": "none", "name": "DGAT1 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q9NCE1", "map_id": "Q9NCE1", "name": "mboa-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010408", "map_id": "WBGene00010408", "name": "mboa-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10557589", "map_id": "none", "name": "AGMO cleaves alkylglycerol into fatty aldehyde and glycerol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_29870", "map_id": "CHEBI:15372", "name": "BH4", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_5696122", "map_id": "CHEBI:52575", "name": "alkylglycerol", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_1497857", "map_id": "CHEBI:15375", "name": "BH2", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_5696116", "map_id": "CHEBI:35746", "name": "fatty aldehyde", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10557586", "map_id": "O17554", "name": "agmo-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "WBGene00007210", "map_id": "WBGene00007210", "name": "agmo-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10507542", "map_id": "none", "name": "glycerol 3-phosphate + acyl-CoA => 1-acylglycerol 3-phosphate + CoASH [mitochondrial membrane-associated]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_76112", "map_id": "CHEBI:16975", "name": "1-acyl LPA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10507537", "map_id": "Q22949", "name": "acl-6", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "false" }, { "id": "WBGene00017261", "map_id": "WBGene00017261", "name": "acl-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10527368", "map_id": "none", "name": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10527365", "map_id": "none", "name": "Homologues of DGAT2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q9XUW0", "map_id": "Q9XUW0", "name": "dgat-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010296", "map_id": "WBGene00010296", "name": "dgat-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O01881", "map_id": "O01881", "name": "AWAT1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021818", "map_id": "WBGene00021818", "name": "AWAT1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q23067", "map_id": "Q23067", "name": "dgtr-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020910", "map_id": "WBGene00020910", "name": "dgtr-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9N4S3", "map_id": "Q9N4S3", "name": "AWAT1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10507593", "map_id": "none", "name": "1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10507586", "map_id": "Q9XXT5", "name": "lpin-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "reaction_10562170", "map_id": "none", "name": "MOGAT1,2,3 transfer acyl group from acyl-CoA to 2-acylglycerol to form DAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_6800352", "map_id": "CHEBI:17389", "name": "2AG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10562167", "map_id": "none", "name": "MOGAT1,2,3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10523735", "map_id": "none", "name": "Rsu-1 interacts with Pinch1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10523726", "map_id": "Q09497", "name": "rsu-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00007924", "map_id": "WBGene00007924", "name": "rsu-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10523731", "map_id": "P50464", "name": "unc-97", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00006826", "map_id": "WBGene00006826", "name": "unc-97", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10523733", "map_id": "none", "name": "Rsu-1:Pinch1 complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P50464", "map_id": "P50464", "name": "unc-97", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q09497", "map_id": "Q09497", "name": "rsu-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10524057", "map_id": "none", "name": "PARVB/Affixin interacts with alpha PIX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10523717", "map_id": "O16785", "name": "pat-6", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00003932", "map_id": "WBGene00003932", "name": "pat-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10524055", "map_id": "none", "name": "ParvB/Affixin:Alpha-Pix", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "O16785", "map_id": "O16785", "name": "pat-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10523721", "map_id": "none", "name": "PARVB interacts with Alpha-actinin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10523712", "map_id": "Q23158", "name": "atn-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10523719", "map_id": "none", "name": "PARVB:alpha actinin", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10512192", "map_id": "none", "name": "GAB1 binds phosphatidylinositol-3,4,5-trisphosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10512159", "map_id": "none", "name": "GRB2:GAB1:PIP3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10512183", "map_id": "none", "name": "PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10512155", "map_id": "none", "name": "EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10512169", "map_id": "none", "name": "GAB1 phosphorylation by EGFR kinase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10512163", "map_id": "none", "name": "EGF-like ligands:p-6Y-EGFR:GRB2:GAB1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10512153", "map_id": "none", "name": "EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10512123", "map_id": "none", "name": "Binding of GRB2 to GAB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10512119", "map_id": "G5EDJ4", "name": "soc-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10512157", "map_id": "none", "name": "PI3K binds to EGF:EGFR:GRB2:GAB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10519952", "map_id": "none", "name": "Serotonin loaded synaptic vesicle docking and priming", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10516777", "map_id": "none", "name": "RIMS1:UNC13B:BZRAP1:Alpha-liprin", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q22366", "map_id": "Q22366", "name": "unc-10", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006750", "map_id": "WBGene00006750", "name": "unc-10", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P27715", "map_id": "P27715", "name": "unc-13", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006752", "map_id": "WBGene00006752", "name": "unc-13", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9N415", "map_id": "Q9N415", "name": "rimb-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006513", "map_id": "WBGene00006513", "name": "rimb-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10519865", "map_id": "none", "name": "Synapsin", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_374940", "compartment_display": "clathrin-sculpted monoamine transport vesicle membrane", "complex": "false" }, { "id": "species_10519944", "map_id": "none", "name": "Serotonin loaded synaptic vesicle", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_374940", "compartment_display": "clathrin-sculpted monoamine transport vesicle membrane", "complex": "true" }, { "id": "Q94057", "map_id": "Q94057", "name": "snb-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00044062", "map_id": "WBGene00044062", "name": "snb-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q95XH1", "map_id": "Q95XH1", "name": "vamp-7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022077", "map_id": "WBGene00022077", "name": "vamp-7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EBK2", "map_id": "G5EBK2", "name": "snb-7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00014084", "map_id": "WBGene00014084", "name": "snb-7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34351", "map_id": "P34351", "name": "snb-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004899", "map_id": "WBGene00004899", "name": "snb-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q19767", "map_id": "Q19767", "name": "snb-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004898", "map_id": "WBGene00004898", "name": "snb-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9GNP0", "map_id": "Q9GNP0", "name": "cat-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000295", "map_id": "WBGene00000295", "name": "cat-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q19136", "map_id": "Q19136", "name": "sue-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006306", "map_id": "WBGene00006306", "name": "sue-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q23056", "map_id": "Q23056", "name": "SYT1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020861", "map_id": "WBGene00020861", "name": "SYT1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q965S5", "map_id": "Q965S5", "name": "snt-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004923", "map_id": "WBGene00004923", "name": "snt-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "K8FE10", "map_id": "K8FE10", "name": "snt-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004922", "map_id": "WBGene00004922", "name": "snt-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O16700", "map_id": "O16700", "name": "snt-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004925", "map_id": "WBGene00004925", "name": "snt-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34693", "map_id": "P34693", "name": "snt-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004921", "map_id": "WBGene00004921", "name": "snt-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q94986", "map_id": "Q94986", "name": "rab-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004267", "map_id": "WBGene00004267", "name": "rab-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10516744", "map_id": "Q9GUM7", "name": "cpx-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00022271", "map_id": "WBGene00022271", "name": "cpx-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10516631", "map_id": "P34815", "name": "unc-18", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10516739", "map_id": "none", "name": "Homologues of SNAP25", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10519946", "map_id": "none", "name": "Docked serotonin loaded synaptic vesicle", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9GUM7", "map_id": "Q9GUM7", "name": "cpx-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10519894", "map_id": "none", "name": "loading of Serotonin in synaptic vesicles", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_374932", "compartment_display": "clathrin-sculpted monoamine transport vesicle lumen" }, { "id": "species_209914", "map_id": "CHEBI:28790", "name": "5HT", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10518406", "map_id": "Q9GNP0", "name": "cat-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_374940", "compartment_display": "clathrin-sculpted monoamine transport vesicle membrane", "complex": "false" }, { "id": "reaction_10519949", "map_id": "none", "name": "Release of docked serotonin loaded synaptic vesicle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10518827", "map_id": "Q9GNP0", "name": "cat-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10516825", "map_id": "Q94986", "name": "rab-3", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10516823", "map_id": "none", "name": "Homologues of SYT1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10516807", "map_id": "none", "name": "SNARE complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10522699", "map_id": "none", "name": "Cation influx mediated by TRPC3/6/7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_426219", "map_id": "none", "name": "Cations", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_426221", "map_id": "none", "name": "Cations", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10520082", "map_id": "none", "name": "cAMP activates EPAC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10520080", "map_id": "none", "name": "RAPGEF3:cAMP complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "P34578", "map_id": "P34578", "name": "epac-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10520163", "map_id": "none", "name": "Potassium voltage-gated channels close in reponse to PKA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10520161", "map_id": "none", "name": "Potassium voltage-gated channels (beta cell, open)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "A0A4V0INI0", "map_id": "A0A4V0INI0", "name": "kvs-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002242", "map_id": "WBGene00002242", "name": "kvs-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "H2KZQ6", "map_id": "H2KZQ6", "name": "exp-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001374", "map_id": "WBGene00001374", "name": "exp-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "J3K003", "map_id": "J3K003", "name": "kvs-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007862", "map_id": "WBGene00007862", "name": "kvs-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q20381", "map_id": "Q20381", "name": "kvs-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018402", "map_id": "WBGene00018402", "name": "kvs-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XXD1", "map_id": "Q9XXD1", "name": "kvs-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012967", "map_id": "WBGene00012967", "name": "kvs-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "U4PLR3", "map_id": "U4PLR3", "name": "kvs-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021948", "map_id": "WBGene00021948", "name": "kvs-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A3B1E007", "map_id": "A0A3B1E007", "name": "shw-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004793", "map_id": "WBGene00004793", "name": "shw-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EC00", "map_id": "G5EC00", "name": "shw-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008819", "map_id": "WBGene00008819", "name": "shw-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EFC3", "map_id": "G5EFC3", "name": "egl-36", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001202", "map_id": "WBGene00001202", "name": "egl-36", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10520051", "map_id": "none", "name": "cAMP activates EPAC2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10520047", "map_id": "P34578", "name": "epac-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10520049", "map_id": "none", "name": "RAPGEF4:cAMP Complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10520167", "map_id": "none", "name": "RAP1A exchanges GDP for GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10520165", "map_id": "none", "name": "RAP1A:GDP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10520075", "map_id": "none", "name": "ER calcium channels open in response to activated PKA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10520065", "map_id": "none", "name": "Ca-channel (closed)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "species_10520073", "map_id": "none", "name": "Ca-channel (open)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10507009", "map_id": "none", "name": "Elongation of pre-rRNA transcript", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_350", "compartment_display": "nucleolus" }, { "id": "species_74985", "map_id": "none", "name": "elongating pre-rRNA transcript", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10506322", "map_id": "none", "name": "RNA Polymerase I promoter escape complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "P46064", "map_id": "P46064", "name": "tag-51", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006430", "map_id": "WBGene00006430", "name": "tag-51", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O01914", "map_id": "O01914", "name": "Ac-TAF1B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017758", "map_id": "WBGene00017758", "name": "Ac-TAF1B", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9UAY9", "map_id": "Q9UAY9", "name": "rpac-40", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019275", "map_id": "WBGene00019275", "name": "rpac-40", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5ED21", "map_id": "G5ED21", "name": "rpoa-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012999", "map_id": "WBGene00012999", "name": "rpoa-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q95X83", "map_id": "Q95X83", "name": "rpoa-49", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017749", "map_id": "WBGene00017749", "name": "rpoa-49", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O17587", "map_id": "O17587", "name": "rpoa-12", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007616", "map_id": "WBGene00007616", "name": "rpoa-12", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q27493", "map_id": "Q27493", "name": "rpoa-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008781", "map_id": "WBGene00008781", "name": "rpoa-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10507007", "map_id": "none", "name": "Chromatin (H3K9me2):CBX3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "P34618", "map_id": "P34618", "name": "cec-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000414", "map_id": "WBGene00000414", "name": "cec-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10506324", "map_id": "none", "name": "Loss of Rrn3 from RNA Polymerase I promoter escape complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10506318", "map_id": "none", "name": "RNA Polymerase I Transcription Initiation complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "P48322", "map_id": "P48322", "name": "RRN3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007980", "map_id": "WBGene00007980", "name": "RRN3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10506238", "map_id": "P48322", "name": "RRN3", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10506242", "map_id": "none", "name": "Binding of RRN3 to RNA Polymerase I", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10506233", "map_id": "none", "name": "RNA Polymerase I Holoenzyme", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10506240", "map_id": "none", "name": "Active RNA Polymerase I", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10544853", "map_id": "none", "name": "Slo3 Potassium Transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10544850", "map_id": "none", "name": "Slo3 Channel", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q95V25", "map_id": "Q95V25", "name": "slo-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004830", "map_id": "WBGene00004830", "name": "slo-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10544843", "map_id": "none", "name": "SPAM1 Binds Hyaluronic Acid", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10544839", "map_id": "G5ECE8", "name": "chhy-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_1297302", "map_id": "CHEBI:16336", "name": "HUA", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10544841", "map_id": "none", "name": "SPAM1:Hyaluronic acid", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10568369", "map_id": "none", "name": "SERPINB13 binds cathepsin L", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_10568365", "map_id": "none", "name": "Cathepsin L", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "true" }, { "id": "species_10568363", "map_id": "none", "name": "Homologues of SERPINB13", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "true" }, { "id": "species_10568367", "map_id": "none", "name": "SERPINB13:cathepsin L", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "true" }, { "id": "reaction_10568373", "map_id": "none", "name": "SERPINB13 binds CTSK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_10542848", "map_id": "none", "name": "Homologues of CTSK", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "true" }, { "id": "species_10568371", "map_id": "none", "name": "CTSK:SERPINB13", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "true" }, { "id": "reaction_10573076", "map_id": "none", "name": "AAMP binds EGFR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_459", "compartment_display": "cytoplasm" }, { "id": "species_10512185", "map_id": "P24348", "name": "let-23", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10573072", "map_id": "E0R7L2", "name": "AAMP", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00013735", "map_id": "WBGene00013735", "name": "AAMP", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10573074", "map_id": "none", "name": "EGFR:AAMP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "E0R7L2", "map_id": "E0R7L2", "name": "AAMP", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10512180", "map_id": "none", "name": "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10512177", "map_id": "none", "name": "EGF-like ligands:p-6Y-EGFR:GRB2:SOS1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10508553", "map_id": "none", "name": "GRB2-1 binds SOS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10506878", "map_id": "none", "name": "GRB2-1:SOS1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10502745", "map_id": "none", "name": "Formation of Cyclin E:Cdk2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10502739", "map_id": "O01501", "name": "cye-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10502743", "map_id": "none", "name": "CCNE:CDK2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10509929", "map_id": "none", "name": "Translocation of Cyclin E:Cdk2 complex to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13231", "compartment_display": "nuclear envelope" }, { "id": "reaction_10502762", "map_id": "none", "name": "Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10502754", "map_id": "none", "name": "Cyclin E:p-CDK2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10512702", "map_id": "none", "name": "CAK-mediated phosphorylation of Cyclin E:Cdk2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10502596", "map_id": "none", "name": "Cyclin E:p-T160-CDK2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10546481", "map_id": "none", "name": "MRE11 binds cytosolic DNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10546477", "map_id": "Q23255", "name": "mre-11", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00003405", "map_id": "WBGene00003405", "name": "mre-11", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_874088", "map_id": "CHEBI:16991", "name": "Double-stranded DNA", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10546479", "map_id": "none", "name": "MRE11:dsDNA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q23255", "map_id": "Q23255", "name": "mre-11", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10546391", "map_id": "none", "name": "DDX41 ubiquitination by TRIM21", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10546380", "map_id": "Q9N5K1", "name": "sacy-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00019245", "map_id": "WBGene00019245", "name": "sacy-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10530724", "map_id": "Q9N3T6", "name": "TRIM21", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00021640", "map_id": "WBGene00021640", "name": "TRIM39", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10546388", "map_id": "none", "name": "K48polyUb-DDX41:TRIM21", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9N3T6", "map_id": "Q9N3T6", "name": "TRIM39", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9N5K1", "map_id": "Q9N5K1", "name": "sacy-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10571225", "map_id": "none", "name": "DDX41 binds bacterial c-di-AMP, c-di-GMP ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_8982080", "map_id": "none", "name": "c-di-AMP, c-di-GMP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:49537", "map_id": "CHEBI:49537", "name": "CHEBI:49537", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:47037", "map_id": "CHEBI:47037", "name": "CHEBI:47037", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10571223", "map_id": "none", "name": "DDX41:c-di-AMP, c-di-GMP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10513873", "map_id": "none", "name": "DAG stimulates protein kinase C-delta", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10513870", "map_id": "none", "name": "Phospho-PKC-delta/epsilon", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10542115", "map_id": "none", "name": "Production of AA by iPLA2 upon FCGR activation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_426925", "map_id": "CHEBI:16110", "name": "PC", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_428981", "map_id": "CHEBI:17504", "name": "LPC", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "reaction_10542106", "map_id": "none", "name": "Hydrolysis of PC to PA by PLD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_429802", "map_id": "CHEBI:16110", "name": "PC", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_264618", "map_id": "CHEBI:15354", "name": "Cho", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_1602448", "map_id": "CHEBI:16337", "name": "PA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10542103", "map_id": "none", "name": "PLD", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10541996", "map_id": "none", "name": "Autophosphorylation of PAK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10530663", "map_id": "none", "name": "C3b binds to cell surface", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10510806", "map_id": "none", "name": "C3b", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10530661", "map_id": "none", "name": "Cell surface:C3b", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10511597", "map_id": "none", "name": "Spontaneous hydrolysis of C3 thioester", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10510798", "map_id": "none", "name": "Complement factor 3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10511595", "map_id": "none", "name": "C3(H2O)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10530687", "map_id": "none", "name": "C4b binds to cell surface", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10510784", "map_id": "none", "name": "C4A(20-675):C4A(1454-1744):S-(L-isoglutamyl)-L-cysteine-C4A(757-1446)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10530685", "map_id": "none", "name": "Cell surface:C4b", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10569040", "map_id": "none", "name": "CD46 binds C4b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10531687", "map_id": "none", "name": "Homologues of CD46", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10569038", "map_id": "none", "name": "CD46:Cell surface:C4b", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10531691", "map_id": "none", "name": "CD46 binds C3b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10531689", "map_id": "none", "name": "CD46:Cell surface:C3b", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10565402", "map_id": "none", "name": "CPN, CPB2 cleave C3a, C5a", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10565379", "map_id": "none", "name": "C3a, C5a", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10565381", "map_id": "none", "name": "C3a-desArg, C5a-desArg", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10565399", "map_id": "none", "name": "CPN, CBP2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "Q22825", "map_id": "Q22825", "name": "cpd-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012073", "map_id": "WBGene00012073", "name": "cpd-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O17754", "map_id": "O17754", "name": "egl-21", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001189", "map_id": "WBGene00001189", "name": "egl-21", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9N5Z3", "map_id": "Q9N5Z3", "name": "tol-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006593", "map_id": "WBGene00006593", "name": "tol-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10545918", "map_id": "none", "name": "Hydrolysis of internal thioester in C4b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10530671", "map_id": "none", "name": "deamidated-Q1013-C4A-derived C4b", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10529380", "map_id": "none", "name": "ISGylation of DDX58", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10529344", "map_id": "Q93413", "name": "drh-3", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00008400", "map_id": "WBGene00008400", "name": "drh-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10529376", "map_id": "none", "name": "ISG15:UBEIL/UbcH8:CEB1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10529378", "map_id": "none", "name": "ISG15:DDX58 conjugate", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q93413", "map_id": "Q93413", "name": "drh-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10529352", "map_id": "none", "name": "CYLD mediated deubiquitination of DDX58 (RIG-I)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10529342", "map_id": "Q93413", "name": "drh-3", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10529349", "map_id": "Q7JMS4", "name": "cyld-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00009594", "map_id": "WBGene00009594", "name": "cyld-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10515197", "map_id": "none", "name": "Translocation of PDK1 to Plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_202277", "map_id": "none", "name": "PIP3, PI(3,4)P2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_202247", "map_id": "CHEBI:16152", "name": "PI(3,4)P2", "type": "catalyst", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10515195", "map_id": "none", "name": "PDK1:PIP2,PIP3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10515220", "map_id": "none", "name": "Translocation of PKC theta to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10514851", "map_id": "P34722", "name": "tpa-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10515218", "map_id": "none", "name": "PKC-theta (open): DAG", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10545484", "map_id": "none", "name": "Autophosphorylation of PKC-theta", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10515204", "map_id": "none", "name": "p-Y90-PKC-theta:DAG", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10545482", "map_id": "none", "name": "p-5Y-PKC-theta:DAG", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10545501", "map_id": "none", "name": "Autophosphorylation of LYN kinase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10545490", "map_id": "none", "name": "Homologues of LYN", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10545498", "map_id": "none", "name": "Homologues of p-Y396-LYN", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10560563", "map_id": "none", "name": "Exocytosis of tertiary granule membrane proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_6799713", "compartment_display": "tertiary granule membrane" }, { "id": "species_10560495", "map_id": "none", "name": "Tertiary granule membrane proteins", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_6799713", "compartment_display": "tertiary granule membrane", "complex": "true" }, { "id": "G5EE29", "map_id": "G5EE29", "name": "trpl-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021404", "map_id": "WBGene00021404", "name": "trpl-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P91448", "map_id": "P91448", "name": "trpl-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004149", "map_id": "WBGene00004149", "name": "trpl-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q19377", "map_id": "Q19377", "name": "TRPM5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008731", "map_id": "WBGene00008731", "name": "TRPM5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q23141", "map_id": "Q23141", "name": "trpl-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020972", "map_id": "WBGene00020972", "name": "trpl-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q19958", "map_id": "Q19958", "name": "sto-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006064", "map_id": "WBGene00006064", "name": "sto-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EFD9", "map_id": "G5EFD9", "name": "phospho-sup-17", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006324", "map_id": "WBGene00006324", "name": "phospho-sup-17", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "U4PBV8", "map_id": "U4PBV8", "name": "tat-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019166", "map_id": "WBGene00019166", "name": "tat-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q20707", "map_id": "Q20707", "name": "tsp-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006630", "map_id": "WBGene00006630", "name": "tsp-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G4RWX0", "map_id": "G4RWX0", "name": "tsp-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006632", "map_id": "WBGene00006632", "name": "tsp-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "H2L006", "map_id": "H2L006", "name": "tsp-14", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006640", "map_id": "WBGene00006640", "name": "tsp-14", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q22495", "map_id": "Q22495", "name": "tsp-12", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006638", "map_id": "WBGene00006638", "name": "tsp-12", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O62466", "map_id": "O62466", "name": "tsp-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006631", "map_id": "WBGene00006631", "name": "tsp-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9NEI8", "map_id": "Q9NEI8", "name": "SLC2A1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00043980", "map_id": "WBGene00043980", "name": "SLC2A1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A0S4XR36", "map_id": "A0A0S4XR36", "name": "ubr-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "C44E4.1d", "map_id": "C44E4.1d", "name": "ubr-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O17599", "map_id": "O17599", "name": "rap-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004308", "map_id": "WBGene00004308", "name": "rap-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q93874", "map_id": "Q93874", "name": "rab-14", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004276", "map_id": "WBGene00004276", "name": "rab-14", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O01312", "map_id": "O01312", "name": "rap-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004309", "map_id": "WBGene00004309", "name": "rap-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10560561", "map_id": "none", "name": "Tertiary granule membrane proteins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10561604", "map_id": "none", "name": "Exocytosis of azurophil granule lumen proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. 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"complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017012", "map_id": "WBGene00017012", "name": "acs-22", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q19878", "map_id": "Q19878", "name": "acs-20", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009218", "map_id": "WBGene00009218", "name": "acs-20", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O44186", "map_id": "O44186", "name": "DEGS1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017996", "map_id": "WBGene00017996", "name": "DEGS1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EC63", "map_id": "G5EC63", "name": "ttm-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013197", "map_id": "WBGene00013197", "name": "ttm-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q20026", "map_id": "Q20026", "name": "chtl-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018037", "map_id": "WBGene00018037", "name": "chtl-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O44836", "map_id": "O44836", "name": "zmp-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019212", "map_id": "WBGene00019212", "name": "zmp-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q20241", "map_id": "Q20241", "name": "tag-120", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006470", "map_id": "WBGene00006470", "name": "tag-120", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8MQ55", "map_id": "Q8MQ55", "name": "xbx-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009580", "map_id": "WBGene00009580", "name": "xbx-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9N3Y5", "map_id": "Q9N3Y5", "name": "TMBIM1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021537", "map_id": "WBGene00021537", "name": "TMBIM1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10562072", "map_id": "none", "name": "Specific granule membrane proteins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10552610", "map_id": "none", "name": "PKC-delta is activated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10552599", "map_id": "none", "name": "DAGs:p-T507,S645,S664-PRKCD", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10552608", "map_id": "none", "name": "DAGs:active p-T507,S645,S664-PRKCD", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10552614", "map_id": "none", "name": "p-Y753,Y759-PLCG2 translocates from cytosol to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10552612", "map_id": "Q22070", "name": "phospho-plc-3", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10552603", "map_id": "Q22070", "name": "phospho-plc-3", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10552601", "map_id": "none", "name": "PKC-delta translocates to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10550601", "map_id": "P34722", "name": "phospho-tpa-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10552606", "map_id": "none", "name": "p-Y753,Y759-PLCG2 hydrolyses PIP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10553376", "map_id": "none", "name": "SFKs phosphorylates RAF1 on Y340,Y341", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10553365", "map_id": "none", "name": "p21 RAS:GTP:p-S338-RAF1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10553371", "map_id": "none", "name": "p21 RAS:GTP:p-S338,Y340,Y341-RAF1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10553373", "map_id": "none", "name": "FYN, LYN", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10553381", "map_id": "none", "name": "PAK phosphorylates p21 RAF1 on S338", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10553378", "map_id": "none", "name": "p21 RAS:GTP:RAF1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10520688", "map_id": "none", "name": "PAK1,2,3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10553383", "map_id": "none", "name": "RAF1 binds p21 RAS:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10521086", "map_id": "Q07292", "name": "lin-45", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10565907", "map_id": "none", "name": "PLA2G2A binds bacterial phospholipids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10535794", "map_id": "none", "name": "PLA2G2A:Ca2+", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_8931784", "map_id": "none", "name": "Anionic phospholipids:microbial cell surface", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "CHEBI:62643", "map_id": "CHEBI:62643", "name": "CHEBI:62643", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10565905", "map_id": "none", "name": "PLA2G2A:phospholipids", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10562932", "map_id": "none", "name": "REG3A oligomerize to form a pore complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10562926", "map_id": "none", "name": "REG3A(38-175):anionic phospholipids", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10562930", "map_id": "none", "name": "REG3A hexamer:anionic phospholipid", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10562950", "map_id": "none", "name": "REG3A binds bacterial phospholipids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10562924", "map_id": "none", "name": "Homologues of REG3A(38-175)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10563816", "map_id": "none", "name": "PI3 binds the bacterial surface", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_6803081", "map_id": "CHEBI:16412", "name": "LPS", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_1222574", "compartment_display": "cell wall", "complex": "false" }, { "id": "species_10563812", "map_id": "none", "name": "PI3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10563814", "map_id": "none", "name": "PI3:LPS", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10562954", "map_id": "none", "name": "REG3A,REG3G binds bacterial peptidoglycan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_6789198", "map_id": "CHEBI:55424", "name": "GlcNac-(1-->4)MurNAc-L-Ala-gamma-D-Glu-L-Lys-(D-Ala)2", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10562952", "map_id": "none", "name": "REG3A(38-175), REG3G(38-175):peptidoglycan", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10563166", "map_id": "none", "name": "BPI binds LPS on the bacterial surface", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10563164", "map_id": "none", "name": "BPI:LPS", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10532731", "map_id": "none", "name": "Activation of Ca2+ activated Potassium channels with small conductance", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10532728", "map_id": "none", "name": "Small conductance Ca2+ activated potassium channel", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q11122", "map_id": "Q11122", "name": "kcnl-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00015387", "map_id": "WBGene00015387", "name": "kcnl-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "V6CLK4", "map_id": "V6CLK4", "name": "kcnl-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008570", "map_id": "WBGene00008570", "name": "kcnl-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EFI1", "map_id": "G5EFI1", "name": "kcnl-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007176", "map_id": "WBGene00007176", "name": "kcnl-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O17697", "map_id": "O17697", "name": "kcnl-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008265", "map_id": "WBGene00008265", "name": "kcnl-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10532702", "map_id": "none", "name": "Activation of Ca2+ activated Potassium channels with Intermediate conductance", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10532699", "map_id": "none", "name": "Homologues of KCNN4", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10513650", "map_id": "none", "name": "Dynamin is recruited to the gap junction plaque", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10512931", "map_id": "none", "name": "planar gap junction plaques associated with Dab2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "A0A486WXX8", "map_id": "A0A486WXX8", "name": "dab-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000894", "map_id": "WBGene00000894", "name": "dab-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10512942", "map_id": "none", "name": "Planar gap junction plaques associated with Dab2 and Dynamin", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10513652", "map_id": "none", "name": "Dab2 is recruited to the junctional plaques", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10512924", "map_id": "none", "name": "planar gap junction plaques", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10512929", "map_id": "A0A486WXX8", "name": "dab-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10524969", "map_id": "none", "name": "Aquaporin-3 passively transports water out of cell", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10524966", "map_id": "none", "name": "AQP3 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10527170", "map_id": "none", "name": "Aquaporins passively transport glycerol into cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10527167", "map_id": "none", "name": "AQP3,7,9,10", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10527172", "map_id": "none", "name": "Aquaporins passively transport water out of cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10527162", "map_id": "none", "name": "AQP0,1,2,3,4,5,7,8,9,10,11,12A", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "G5EEK0", "map_id": "G5EEK0", "name": "aqp-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000172", "map_id": "WBGene00000172", "name": "aqp-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10527174", "map_id": "none", "name": "Aquaporins passively transport glycerol out of cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10527179", "map_id": "none", "name": "Aquaporins passively transport urea out of cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_432019", "map_id": "CHEBI:16199", "name": "Urea", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10527176", "map_id": "none", "name": "AQP9,10", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10527165", "map_id": "none", "name": "Aquaporins passively transport water into cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10527181", "map_id": "none", "name": "Aquaporins passively transport urea into cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10551505", "map_id": "none", "name": "CYGB binds O2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10551501", "map_id": "none", "name": "CYGB dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "O17824", "map_id": "O17824", "name": "glb-14", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008996", "map_id": "WBGene00008996", "name": "glb-14", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10551503", "map_id": "none", "name": "CYGB dimer:O2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10570320", "map_id": "none", "name": "Neuroglobin:oxygen dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10570316", "map_id": "none", "name": "NGB:ferroheme b:O2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q7YZV1", "map_id": "Q7YZV1", "name": "glb-7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016024", "map_id": "WBGene00016024", "name": "glb-7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10570314", "map_id": "none", "name": "NGB:ferroheme b", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10570501", "map_id": "none", "name": "CYGB:O2 dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10570318", "map_id": "none", "name": "Neuroglobin binds oxygen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10522434", "map_id": "none", "name": "SLC4A5,7,9 cotransport Na+ with 3HCO3-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_425425", "map_id": "CHEBI:17544", "name": "HCO3-", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10522431", "map_id": "none", "name": "SLC4A5,7,9", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10567850", "map_id": "none", "name": "SLC4A4 cotransports Na+ with 3HCO3-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10567847", "map_id": "none", "name": "Homologues of SLC4A4", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10522447", "map_id": "none", "name": "Na+-driven Cl-/HCO3- exchanger transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10522444", "map_id": "none", "name": "Na+-driven Cl-/HCO3- exchanger proteins", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10555169", "map_id": "none", "name": "Phosphorylated MAPKs translocate into the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10555165", "map_id": "none", "name": "p-T,Y MAPK monomers and dimers", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10555167", "map_id": "none", "name": "p-T,Y MAPK monomers and dimers", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10555224", "map_id": "none", "name": "Cytosolic DUSPs dephosphorylate MAPKs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10555201", "map_id": "none", "name": "MAPK monomers and dimers", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10555221", "map_id": "none", "name": "cytosolic MAPK DUSPs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10508594", "map_id": "none", "name": "MAP2K1 phosphorylates MAPK3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10508567", "map_id": "none", "name": "p-2S-MAP2K1:MAPK3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10508585", "map_id": "none", "name": "p-T,Y-MAPK3:p-2S-MAP2K1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10508590", "map_id": "Q10664", "name": "phospho-mek-2", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10508569", "map_id": "none", "name": "MAP2K1 binds MAPK3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10508565", "map_id": "P39745", "name": "mpk-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10508560", "map_id": "Q10664", "name": "phospho-mek-2", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10509182", "map_id": "none", "name": "Inactivation of MAP2K1 by CDK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10509173", "map_id": "none", "name": "MAP2K1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10509179", "map_id": "P34556", "name": "phospho-cdk-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10508606", "map_id": "none", "name": "Dissociation of p-T,Y-MAPK3:MAP2K1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10570242", "map_id": "none", "name": "KDM6B binds iron", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10546680", "map_id": "none", "name": "Homologues of KDM6B", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_111793", "map_id": "CHEBI:29033", "name": "Fe2+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10546682", "map_id": "none", "name": "KDM6B:Fe2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10546756", "map_id": "none", "name": "PRC2-EZH2 trimethylates nucleosomes associated with CDKN2A promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10546668", "map_id": "none", "name": "CDKN2A Gene:Nucleosome", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10546666", "map_id": "none", "name": "CDKN2A Gene:H3K27Me3-Nucleosome", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10517100", "map_id": "none", "name": "PRC2 (EZH2) Core", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9GYS1", "map_id": "Q9GYS1", "name": "mes-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003224", "map_id": "WBGene00003224", "name": "mes-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O17514", "map_id": "O17514", "name": "mes-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003220", "map_id": "WBGene00003220", "name": "mes-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10546703", "map_id": "none", "name": "ROS oxidize thioredoxin and activate MAP3K5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10546692", "map_id": "none", "name": "MAP3K5:TXN", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q21029", "map_id": "Q21029", "name": "nsy-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003822", "map_id": "WBGene00003822", "name": "nsy-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10546690", "map_id": "Q21029", "name": "nsy-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10546697", "map_id": "Q23356", "name": "mig-15", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00003247", "map_id": "WBGene00003247", "name": "mig-15", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10546707", "map_id": "none", "name": "MAP3K5 phosphorylates MKK3 and MKK6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10525576", "map_id": "none", "name": "MAP2K3,MAP2K6", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10546685", "map_id": "none", "name": "KDM6B demethylates H3K27me3 on p16INK4A promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10524560", "map_id": "none", "name": "14-3-3-zeta binds Raf1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10507059", "map_id": "none", "name": "YWHAZ dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10524558", "map_id": "none", "name": "14-3-3-zeta:Raf1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10524541", "map_id": "none", "name": "c-Src binds Raf1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10524539", "map_id": "none", "name": "Active c-Src:Raf1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10516411", "map_id": "none", "name": "Tryptophan is hydroxylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_71112", "map_id": "CHEBI:15374", "name": "4aOH-BH4", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_209911", "map_id": "CHEBI:17780", "name": "5HTP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10516408", "map_id": "none", "name": "TPH:Fe++", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "G5EED8", "map_id": "G5EED8", "name": "tph-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006600", "map_id": "WBGene00006600", "name": "tph-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10516429", "map_id": "none", "name": "Decarboxylation of 5-hydroxytryptophan forms serotonin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10516426", "map_id": "none", "name": "DDC dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "O45137", "map_id": "O45137", "name": "bas-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000239", "map_id": "WBGene00000239", "name": "bas-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10533009", "map_id": "none", "name": "Phosphorylation of LIN52 component of MuvB by DYRK1A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10533001", "map_id": "none", "name": "MuvB complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q95QD7", "map_id": "Q95QD7", "name": "lin-54", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003037", "map_id": "WBGene00003037", "name": "lin-54", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q10120", "map_id": "Q10120", "name": "lin-52", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003035", "map_id": "WBGene00003035", "name": "lin-52", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P30630", "map_id": "P30630", "name": "lin-9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002998", "map_id": "WBGene00002998", "name": "lin-9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q23482", "map_id": "Q23482", "name": "lin-37", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003022", "map_id": "WBGene00003022", "name": "lin-37", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10532993", "map_id": "none", "name": "p-MuvB complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10533006", "map_id": "Q8WQL7", "name": "mbk-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00003149", "map_id": "WBGene00003149", "name": "mbk-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10533091", "map_id": "none", "name": "p107 (RBL1) binds CyclinE/A:CDK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10533075", "map_id": "none", "name": "Cyclin E/A:CDK2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10533089", "map_id": "none", "name": "RBL1:Cyclin E/A:CDK2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10532997", "map_id": "none", "name": "p130 (RBL2) associates with MuvB to form DREAM complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10532097", "map_id": "none", "name": "RBL2:E2F4,E2F5:TFDP1,TFDP2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10532995", "map_id": "none", "name": "DREAM complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10533079", "map_id": "none", "name": "p130 (RBL2) in complex with E2F4/5:DP1/2 binds to cyclin E/A:CDK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10533077", "map_id": "none", "name": "RBL2:E2F4/5:DP1/2:Cyclin E/A:CDK2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10532123", "map_id": "none", "name": "Recruitment of HDAC1 by p130 (RBL2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10532119", "map_id": "G5ECH0", "name": "hda-3", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10532121", "map_id": "none", "name": "HDAC1:RBL2:E2F4,E2F5:TFDP1,TFDP2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10533083", "map_id": "none", "name": "p130 (RBL2) binds Cyclin E/A:CDK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10533081", "map_id": "none", "name": "RBL2:Cyclin E/A:CDK2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10532127", "map_id": "none", "name": "Recruitment of HDAC1 by p107 (RBL1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10532125", "map_id": "none", "name": "HDAC1:RBL1:E2F4:TFDP1,TFDP2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10533087", "map_id": "none", "name": "p107 (RBL1) in complex with E2F4:DP1/2 binds to cyclin E/A:CDK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10533085", "map_id": "none", "name": "RBL1:E2F4:DP1/2:Cyclin E/A:CDK2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10509407", "map_id": "none", "name": "Detection of damage during initiation of DNA synthesis in S-phase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_113656", "map_id": "none", "name": "RNA primer-DNA primer:origin duplex with DNA damage", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10502244", "map_id": "none", "name": "Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10502184", "map_id": "Q9U2C2", "name": "mcm-10", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10502242", "map_id": "none", "name": "MCM10:pre-replicative complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10502246", "map_id": "none", "name": "Cdt1 is displaced from the pre-replicative complex.", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10502230", "map_id": "none", "name": "MCM10:active pre-replicative complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10502099", "map_id": "Q86S68", "name": "cdt-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10502584", "map_id": "none", "name": "DNA polymerase epsilon binds at the origin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_68419", "map_id": "none", "name": "origin of replication", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10502147", "map_id": "none", "name": "DNA polymerase epsilon:origin complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10502236", "map_id": "none", "name": "Cdc45 associates with the pre-replicative complex at the origin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10502232", "map_id": "none", "name": "CDK:DDK:MCM10:active pre-replicative complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10502161", "map_id": "Q7JMR0", "name": "evl-18", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10502156", "map_id": "none", "name": "DNA polymerase alpha:primase binds at the origin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10546046", "map_id": "none", "name": "SENP1,2,5 proteolytically process SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10546014", "map_id": "P55853", "name": "smo-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10546043", "map_id": "none", "name": "SENP1,2,5", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10570130", "map_id": "none", "name": "ZBED1 (DREF) SUMOylates CHD3 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10548000", "map_id": "none", "name": "Homologues of CHD3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10570122", "map_id": "none", "name": "SUMO1:CHD3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10570127", "map_id": "Q21374", "name": "ZBED1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00010704", "map_id": "WBGene00010704", "name": "ZBED1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10549430", "map_id": "none", "name": "SUMOylation of HDAC2 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10547980", "map_id": "none", "name": "Homologues of HDAC2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10549428", "map_id": "none", "name": "SUMO1:HDAC2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10549306", "map_id": "none", "name": "SUMOylation of Histone H4 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10549304", "map_id": "none", "name": "SUMO1:HIST1H4", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10549403", "map_id": "none", "name": "PIAS1 SUMOylates SATB1 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10518112", "map_id": "Q86MI0", "name": "dve-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00022861", "map_id": "WBGene00022861", "name": "dve-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10549401", "map_id": "none", "name": "SUMO1:SATB1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q86MI0", "map_id": "Q86MI0", "name": "dve-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10549391", "map_id": "none", "name": "SUMOylation of HDAC1 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10549389", "map_id": "none", "name": "2SUMO1:HDAC1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10508432", "map_id": "none", "name": "Concentrative transport (import) of nucleosides plus sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_179740", "map_id": "none", "name": "ligands of SLC28A2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_83927", "map_id": "CHEBI:17596", "name": "Ino", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "CHEBI:16750", "map_id": "CHEBI:16750", "name": "CHEBI:16750", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_179741", "map_id": "none", "name": "ligands of SLC28A2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10508429", "map_id": "G5EE77", "name": "slc-28.1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "WBGene00017867", "map_id": "WBGene00017867", "name": "slc-28.1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10508417", "map_id": "none", "name": "Concentrative transport (import) of a nucleoside and a sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_179738", "map_id": "none", "name": "ligands of SLC28A1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "CHEBI:17256", "map_id": "CHEBI:17256", "name": "CHEBI:17256", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_179739", "map_id": "none", "name": "ligands of SLC28A1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10508414", "map_id": "G5EE77", "name": "slc-28.1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10508420", "map_id": "none", "name": "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_179743", "map_id": "none", "name": "ligands of SLC28A3 & 29A1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_179737", "map_id": "none", "name": "ligands of SLC28A3 & 29A1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10508404", "map_id": "Q93690", "name": "ent-6", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "WBGene00009499", "map_id": "WBGene00009499", "name": "ent-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10527797", "map_id": "none", "name": "SLC29A3 transports nucleosides from lysosomal lumen to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_727782", "map_id": "none", "name": "nucleosides", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "true" }, { "id": "species_83951", "map_id": "CHEBI:16708", "name": "Ade", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_727746", "map_id": "none", "name": "nucleosides", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10527794", "map_id": "Q93690", "name": "ent-6", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "false" }, { "id": "reaction_10508422", "map_id": "none", "name": "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10508407", "map_id": "none", "name": "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_179747", "map_id": "none", "name": "ligands of SLC29A2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_83956", "map_id": "CHEBI:16235", "name": "Gua", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_113599", "map_id": "CHEBI:17368", "name": "Hyp", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_83960", "map_id": "CHEBI:17821", "name": "Thy", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "CHEBI:16040", "map_id": "CHEBI:16040", "name": "CHEBI:16040", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_179742", "map_id": "none", "name": "ligands of SLC29A2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10508402", "map_id": "Q93690", "name": "ent-6", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10508409", "map_id": "none", "name": "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10510169", "map_id": "none", "name": "SLC25A5,6 dimers exchange ATP for ADP across the mitochondrial inner membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane" }, { "id": "species_10510166", "map_id": "none", "name": "SLC25A5 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "P91270", "map_id": "P91270", "name": "SLC25A5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017770", "map_id": "WBGene00017770", "name": "SLC25A5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10508427", "map_id": "none", "name": "Concentrative transport (import) of a nucleoside and two sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10508424", "map_id": "G5EE77", "name": "slc-28.1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10528229", "map_id": "none", "name": "SLC27A1,4,6 transport LCFAs from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_879559", "map_id": "none", "name": "LCFAs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_879544", "map_id": "none", "name": "LCFAs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10528226", "map_id": "none", "name": "SLC27A1,4,6", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10527805", "map_id": "none", "name": "SLC33A1 transports Ac-CoA from cytosol to Golgi lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_727753", "map_id": "CHEBI:15351", "name": "Ac-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10527802", "map_id": "Q22816", "name": "SLC33A1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "WBGene00012033", "map_id": "WBGene00012033", "name": "SLC33A1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10528210", "map_id": "none", "name": "SLCOs, SLC16A2 transport T3,T4 from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_879603", "map_id": "none", "name": "T3,T4", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_352326", "map_id": "CHEBI:18332", "name": "T4", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_879628", "map_id": "none", "name": "T3,T4", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10528207", "map_id": "none", "name": "SLCOs, SLC16A2 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q95ZT3", "map_id": "Q95ZT3", "name": "SLCO1C1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018568", "map_id": "WBGene00018568", "name": "SLCO1C1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O62421", "map_id": "O62421", "name": "SLCO1C1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q20538", "map_id": "Q20538", "name": "SLCO1C1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q93550", "map_id": "Q93550", "name": "SLCO1C1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "X5LPS1", "map_id": "X5LPS1", "name": "SLCO4A1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "X5LV99", "map_id": "X5LV99", "name": "SLCO4A1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10528168", "map_id": "none", "name": "SLCO2B1 has a narrow substrate specificity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_879553", "map_id": "none", "name": "SLCO2B1 substrates", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "CHEBI:63836", "map_id": "CHEBI:63836", "name": "CHEBI:63836", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_879654", "map_id": "none", "name": "SLCO2B1 substrates", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10528165", "map_id": "none", "name": "Homologues of SLCO2B1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10572296", "map_id": "none", "name": "SLCO1B1 transports T3,T4 from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10528178", "map_id": "none", "name": "Homologues of SLCO1B1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10528234", "map_id": "none", "name": "SLCO4C1 mediates the transport of digoxin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_879521", "map_id": "CHEBI:4551", "name": "DIGX", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_879517", "map_id": "CHEBI:4551", "name": "DIGX", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10528231", "map_id": "Q9XWC5", "name": "SLCO4C1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10528155", "map_id": "none", "name": "SLCO2A1 transports PGT substrates from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_879566", "map_id": "none", "name": "PGT substrates", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "CHEBI:15544", "map_id": "CHEBI:15544", "name": "CHEBI:15544", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_879614", "map_id": "none", "name": "PGT substrates", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10528152", "map_id": "none", "name": "Homologues of SLCO2A1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10543903", "map_id": "none", "name": "AKT binds PDPK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10513830", "map_id": "none", "name": "p-S-AKT:PIP3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10513832", "map_id": "none", "name": "p-S-AKT:PDPK1:PIP3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10543806", "map_id": "none", "name": "PIP3 recruits PDPK1 to the membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10543581", "map_id": "none", "name": "PDPK1 binds PIP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10543579", "map_id": "none", "name": "PDPK1:PIP2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10513851", "map_id": "none", "name": "PDPK1 phosphorylates AKT at T308", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10513960", "map_id": "none", "name": "TORC2 (mTOR) phosphorylates AKT at S473", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10513939", "map_id": "none", "name": "AKT:PIP3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10513958", "map_id": "none", "name": "AKT:PIP3:THEM4/TRIB3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10509479", "map_id": "none", "name": "RAC1,RAC2,RHOG activate PI3K", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10509473", "map_id": "none", "name": "RAC1:GTP,RAC2:GTP,RHOG:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10509477", "map_id": "none", "name": "RAC1:GTP,RAC2:GTP,RHOG:GTP:PI3K alpha", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10514322", "map_id": "none", "name": "THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10513956", "map_id": "G5EED4", "name": "nipi-3", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10514330", "map_id": "none", "name": "PTEN dephosphorylates PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10514327", "map_id": "G5EE01", "name": "daf-18", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00000913", "map_id": "WBGene00000913", "name": "phospho-daf-18", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10543905", "map_id": "none", "name": "PIP3 recruits AKT to the membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10565073", "map_id": "none", "name": "Proteasome degrades polyubiquitinated PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10565071", "map_id": "none", "name": "PolyUb-PTEN, K48polyUb-K289-PTEN, PolyUb-K324,K344,K349-RibC-E40,E150,D326-PTEN", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "G5EE01", "map_id": "G5EE01", "name": "phospho-daf-18", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10564578", "map_id": "none", "name": "PTEN binds FRK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10564574", "map_id": "O45539", "name": "phospho-src-2", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10564576", "map_id": "none", "name": "PTEN:p-Y387-FRK", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10565061", "map_id": "none", "name": "Casein kinase II phosphorylates PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10565059", "map_id": "G5EE01", "name": "phospho-daf-18", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10563159", "map_id": "none", "name": "NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10563152", "map_id": "G5EE01", "name": "daf-18", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10563156", "map_id": "none", "name": "NEDD4,STUB1,WWP2 and XIAP", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10565079", "map_id": "none", "name": "TRIM27 binds PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10565075", "map_id": "Q9N3T6", "name": "TRIM27", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10565077", "map_id": "none", "name": "PTEN:TRIM27", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10568856", "map_id": "none", "name": "MKRN1 polyubiquitinates PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10563162", "map_id": "G5EE01", "name": "daf-18", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10564584", "map_id": "none", "name": "FRK phosphorylates PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10564581", "map_id": "G5EE01", "name": "phospho-daf-18", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10568861", "map_id": "none", "name": "RNF146 polyubiquitinates PARylated PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10568858", "map_id": "G5EE01", "name": "phospho-daf-18", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10565069", "map_id": "G5EE01", "name": "phospho-daf-18", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10547738", "map_id": "Q8WQB0", "name": "RNF146", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00013674", "map_id": "WBGene00013674", "name": "RNF146", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10565085", "map_id": "none", "name": "TRIM27 polyubiquitinates PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10565082", "map_id": "G5EE01", "name": "daf-18", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10568800", "map_id": "none", "name": "MAF1 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13231", "compartment_display": "nuclear envelope" }, { "id": "species_10568791", "map_id": "Q9TZN2", "name": "mafr-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00016622", "map_id": "WBGene00016622", "name": "phospho-mafr-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10568789", "map_id": "Q9TZN2", "name": "mafr-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10568738", "map_id": "none", "name": "MECOM (EVI1) recruits polycomb repressor complexes (PRCs) to the PTEN gene promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10568732", "map_id": "none", "name": "MECOM:PTEN gene", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q22024", "map_id": "Q22024", "name": "egl-43", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10568730", "map_id": "none", "name": "PRC1.4,PRC2 (EZH2) core", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10568736", "map_id": "none", "name": "MECOM:(PRC1.4,PRC2 (EZH2) core):PTEN gene", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10568726", "map_id": "none", "name": "SALL4 recruits NuRD to PTEN gene", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10548019", "map_id": "none", "name": "NuRD complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10568720", "map_id": "none", "name": "SALL4:PTEN gene", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "G5EFF4", "map_id": "G5EFF4", "name": "sem-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004773", "map_id": "WBGene00004773", "name": "sem-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10568724", "map_id": "none", "name": "SALL4:NuRD:PTEN gene", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10568798", "map_id": "none", "name": "mTORC1 phosphorylates MAF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10568796", "map_id": "Q9TZN2", "name": "phospho-mafr-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10563141", "map_id": "none", "name": "Monoubiquitinated PTEN translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10563135", "map_id": "G5EE01", "name": "daf-18", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10563139", "map_id": "G5EE01", "name": "daf-18", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10563146", "map_id": "none", "name": "USP7 deubiquitinates monoubiquitinated PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10563143", "map_id": "G5EE01", "name": "daf-18", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10556169", "map_id": "Q7JKC3", "name": "math-33", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10546215", "map_id": "G5ED20", "name": "tam-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00006523", "map_id": "WBGene00006523", "name": "tam-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10563149", "map_id": "none", "name": "Deubiquitinated PTEN translocates to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10503794", "map_id": "none", "name": "homogentisate + O2 => maleylacetoacetate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_30337", "map_id": "CHEBI:16169", "name": "HGTA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_31135", "map_id": "CHEBI:17105", "name": "4MAA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10503791", "map_id": "none", "name": "HGD hexamer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9Y041", "map_id": "Q9Y041", "name": "hgo-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001843", "map_id": "WBGene00001843", "name": "hgo-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10503765", "map_id": "none", "name": "tyrosine + alpha-ketoglutarate <=> p-hydroxyphenylpyruvate + glutamate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29406", "map_id": "CHEBI:16810", "name": "2OG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_29506", "map_id": "CHEBI:58315", "name": "L-Tyr", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_31365", "map_id": "CHEBI:15999", "name": "HPPYRA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10503762", "map_id": "none", "name": "TAT dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q93703", "map_id": "Q93703", "name": "tatn-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009628", "map_id": "WBGene00009628", "name": "tatn-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10503814", "map_id": "none", "name": "fumarylacetoacetate => fumarate + acetoacetate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_31175", "map_id": "CHEBI:18034", "name": "4FAA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_29666", "map_id": "CHEBI:13705", "name": "ACA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_29586", "map_id": "CHEBI:37154", "name": "FUMA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10503811", "map_id": "none", "name": "FAH dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q94272", "map_id": "Q94272", "name": "fah-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019620", "map_id": "WBGene00019620", "name": "fah-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10503784", "map_id": "none", "name": "p-hydroxyphenylpyruvate + O2 => homogentisate + CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10503781", "map_id": "none", "name": "HPD:AscH-:Fe2+ dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q18347", "map_id": "Q18347", "name": "HPD", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016294", "map_id": "WBGene00016294", "name": "HPD", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q22633", "map_id": "Q22633", "name": "hpd-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001993", "map_id": "WBGene00001993", "name": "hpd-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_198836", "map_id": "CHEBI:38290", "name": "AscH-", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "reaction_10503804", "map_id": "none", "name": "maleylacetoacetate => fumarylacetoacetate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10503801", "map_id": "none", "name": "GSTZ1 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10534912", "map_id": "none", "name": "DLCL is acylated to MLCL by LCLAT1 (ER)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_1524080", "map_id": "CHEBI:60431", "name": "DLCL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_1524069", "map_id": "CHEBI:60430", "name": "MLCL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10507525", "map_id": "O16526", "name": "acl-8", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "WBGene00020264", "map_id": "WBGene00020264", "name": "acl-8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10534881", "map_id": "none", "name": "MLCL and PC are converted to CL and 1-acyl LPC by TAZ (IM) (Reversible)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane" }, { "id": "species_1524075", "map_id": "CHEBI:16110", "name": "PC", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "species_1498773", "map_id": "CHEBI:60430", "name": "MLCL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "species_1524072", "map_id": "CHEBI:28494", "name": "cardiolipin", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "species_1524079", "map_id": "CHEBI:17504", "name": "1-acyl LPC", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "species_10534878", "map_id": "Q23598", "name": "acl-3", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "WBGene00006491", "map_id": "WBGene00006491", "name": "acl-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10534899", "map_id": "none", "name": "MLCL and PE are converted to CL and 1-acyl LPE by TAZ (IM) (Reversible)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane" }, { "id": "species_1524083", "map_id": "CHEBI:16038", "name": "PE", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "species_1524089", "map_id": "CHEBI:29017", "name": "1-acyl LPE", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "reaction_10534868", "map_id": "none", "name": "MLCL is acylated to CL by HADH (IM)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane" }, { "id": "species_10534865", "map_id": "none", "name": "HADH octamer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "reaction_10534910", "map_id": "none", "name": "MLCL is acylated to CL by LCLAT1 (ER)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_1524081", "map_id": "CHEBI:28494", "name": "CL", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "reaction_10520252", "map_id": "none", "name": "Olfactory Receptor - G Protein olfactory trimer complex formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10520171", "map_id": "none", "name": "GNAL:GNB1:GNG13", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "G5ECT6", "map_id": "G5ECT6", "name": "gpc-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001682", "map_id": "WBGene00001682", "name": "gpc-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10520178", "map_id": "Q86ME6", "name": "dop-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10520198", "map_id": "none", "name": "Olfactory receptor:G protein trimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10520250", "map_id": "none", "name": "REEPs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q10010", "map_id": "Q10010", "name": "REEP1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020562", "map_id": "WBGene00020562", "name": "REEP1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34296", "map_id": "P34296", "name": "REEP1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10520173", "map_id": "none", "name": "G Protein trimer formation (olfactory)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10509147", "map_id": "G5ECT6", "name": "gpc-2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10510821", "map_id": "P17343", "name": "gpb-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10511281", "map_id": "none", "name": "Homologues of GNAL", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10568896", "map_id": "none", "name": "F1Fo ATP synthase dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane" }, { "id": "species_10510406", "map_id": "none", "name": "F1Fo ATP synthase", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "O16314", "map_id": "O16314", "name": "ATP5S", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00015460", "map_id": "WBGene00015460", "name": "ATP5S", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q18803", "map_id": "Q18803", "name": "asg-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000210", "map_id": "WBGene00000210", "name": "asg-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q17763", "map_id": "Q17763", "name": "atp-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007385", "map_id": "WBGene00007385", "name": "atp-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q19126", "map_id": "Q19126", "name": "asb-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000207", "map_id": "WBGene00000207", "name": "asb-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9BKS0", "map_id": "Q9BKS0", "name": "ATP5G1(1-61)", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022336", "map_id": "WBGene00022336", "name": "ATP5G1(1-61)", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q21732", "map_id": "Q21732", "name": "ATP5I", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011015", "map_id": "WBGene00011015", "name": "ATP5I", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O16517", "map_id": "O16517", "name": "atp-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020275", "map_id": "WBGene00020275", "name": "atp-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q22021", "map_id": "Q22021", "name": "ATP5J2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011273", "map_id": "WBGene00011273", "name": "ATP5J2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q09544", "map_id": "Q09544", "name": "ATP5D", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019061", "map_id": "WBGene00019061", "name": "ATP5D", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XXK1", "map_id": "Q9XXK1", "name": "atp-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010419", "map_id": "WBGene00010419", "name": "atp-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O16298", "map_id": "O16298", "name": "hpo-18", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017982", "map_id": "WBGene00017982", "name": "hpo-18", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P46561", "map_id": "P46561", "name": "atp-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000229", "map_id": "WBGene00000229", "name": "atp-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q95XJ0", "map_id": "Q95XJ0", "name": "ATP5C1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022089", "map_id": "WBGene00022089", "name": "ATP5C1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7JNG1", "map_id": "Q7JNG1", "name": "atp-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000230", "map_id": "WBGene00000230", "name": "atp-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10568894", "map_id": "none", "name": "F1Fo ATP synthase dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "reaction_10549204", "map_id": "none", "name": "SRD5A3 reduces pPNOL to DCHOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_4419981", "map_id": "CHEBI:67132", "name": "pPNOL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_453087", "compartment_display": "integral component of cytoplasmic side of endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_449221", "map_id": "CHEBI:16091", "name": "DCHOL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_453087", "compartment_display": "integral component of cytoplasmic side of endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10549201", "map_id": "Q17428", "name": "SRD5A3", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "WBGene00007102", "map_id": "WBGene00007102", "name": "SRD5A3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10525099", "map_id": "none", "name": "DOLK phosphorylates DCHOL to DOLP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_110094", "map_id": "CHEBI:17239", "name": "CDP", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10525096", "map_id": "Q56VX7", "name": "dolk-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "WBGene00044233", "map_id": "WBGene00044233", "name": "dolk-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10549196", "map_id": "none", "name": "DHDDS:NUS1 elongates E,E-FPP with (n)IPPP to form pPPP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_4419987", "map_id": "CHEBI:17407", "name": "E,E-FPP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_4419982", "map_id": "CHEBI:37531", "name": "pPPP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_453087", "compartment_display": "integral component of cytoplasmic side of endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10549193", "map_id": "none", "name": "DHDDS:NUS1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q5FC21", "map_id": "Q5FC21", "name": "DHDDS", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00044025", "map_id": "WBGene00044025", "name": "DHDDS", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q20118", "map_id": "Q20118", "name": "NUS1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009505", "map_id": "WBGene00009505", "name": "NUS1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10523190", "map_id": "none", "name": "SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane" }, { "id": "species_428040", "map_id": "CHEBI:15378", "name": "H+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_428639", "map_id": "CHEBI:17012", "name": "Neu5Ac", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_428633", "map_id": "CHEBI:17012", "name": "Neu5Ac", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10523187", "map_id": "Q03567", "name": "SLC17A5", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "false" }, { "id": "WBGene00008000", "map_id": "WBGene00008000", "name": "SLC17A5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10525409", "map_id": "none", "name": "GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29472", "map_id": "CHEBI:58359", "name": "L-Gln", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10525406", "map_id": "none", "name": "GFPT1,2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q19130", "map_id": "Q19130", "name": "gfat-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008546", "map_id": "WBGene00008546", "name": "gfat-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q19699", "map_id": "Q19699", "name": "gfat-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009035", "map_id": "WBGene00009035", "name": "gfat-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10525137", "map_id": "none", "name": "GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_532204", "map_id": "CHEBI:7125", "name": "AcGlcN1P", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10525134", "map_id": "none", "name": "2xUAP1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q18493", "map_id": "Q18493", "name": "UAP1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007965", "map_id": "WBGene00007965", "name": "UAP1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10563013", "map_id": "none", "name": "NAGK dimer phosphorylates GlcNAc, GlcNGc to GlcNAc-6-P, GlcNGc-6-P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_6803785", "map_id": "none", "name": "GlcNAc, GlcNGc", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:27459", "map_id": "CHEBI:27459", "name": "CHEBI:27459", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_6803738", "map_id": "none", "name": "GlcNAc-6-P, GlcNGc-6-P", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_449703", "map_id": "CHEBI:15784", "name": "AcGlcN6P", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_6803743", "map_id": "CHEBI:88130", "name": "GlcNGc-6-P", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10563010", "map_id": "none", "name": "NAGK dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q23196", "map_id": "Q23196", "name": "NAGK", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021056", "map_id": "WBGene00021056", "name": "NAGK", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10525061", "map_id": "none", "name": "Isomerization of GlcNAc6P to GlcNAc1P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10525058", "map_id": "Q19680", "name": "PGM3", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00009006", "map_id": "WBGene00009006", "name": "PGM3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10525419", "map_id": "none", "name": "Acetylation of glucosamine 6-phosphate to GlcNAc6P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10525416", "map_id": "none", "name": "2xGNPNAT1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q17427", "map_id": "Q17427", "name": "gna-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001646", "map_id": "WBGene00001646", "name": "gna-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10563021", "map_id": "none", "name": "AMDHD2 hydrolyses GlcNGc-6-P to GlcN6P and CCA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_193473", "map_id": "CHEBI:16359", "name": "CCA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10563018", "map_id": "P34480", "name": "AMDHD2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00010308", "map_id": "WBGene00010308", "name": "AMDHD2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10527233", "map_id": "none", "name": "MPI isomerises Fru6P to Man6P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_532562", "map_id": "CHEBI:17369", "name": "Man6P", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10527230", "map_id": "P34650", "name": "MPI", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00014013", "map_id": "WBGene00014013", "name": "MPI", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10525119", "map_id": "none", "name": "PMM1,2 isomerise Man6P to Man1P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_532531", "map_id": "CHEBI:35374", "name": "Man1P", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10525116", "map_id": "none", "name": "PMM1,2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9XUE6", "map_id": "Q9XUE6", "name": "PMM1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009925", "map_id": "WBGene00009925", "name": "PMM1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10558241", "map_id": "none", "name": "FUK phosphorylates beta-Fuc to Fuc1P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_6787678", "map_id": "CHEBI:42589", "name": "beta-Fuc", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_6787542", "map_id": "CHEBI:12387", "name": "Fuc1P", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10558238", "map_id": "Q18214", "name": "FUK", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00007745", "map_id": "WBGene00007745", "name": "FUK", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10558259", "map_id": "none", "name": "GMDS dehydrates GDP-Man to GDP-DHDMan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_6787618", "map_id": "CHEBI:16955", "name": "GDP-DHDMan", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10558256", "map_id": "Q18801", "name": "bre-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00000266", "map_id": "WBGene00000266", "name": "bre-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10558262", "map_id": "none", "name": "TSTA3 dimer reduces GDP-KDGal to GDP-Fuc", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_6787646", "map_id": "CHEBI:86476", "name": "GDP-KDGal", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10558248", "map_id": "none", "name": "TSTA3 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "G5EER4", "map_id": "G5EER4", "name": "ger-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019813", "map_id": "WBGene00019813", "name": "ger-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10558233", "map_id": "none", "name": "FPGT transfers guanylyl group from GTP to Fuc1P to form GDP-Fuc", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10558230", "map_id": "Q0PDK5", "name": "FPGT", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00044903", "map_id": "WBGene00044903", "name": "FPGT", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10558251", "map_id": "none", "name": "TSTA3 dimer epimerises GDP-DHDMan to GDP-KDGal", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10555857", "map_id": "none", "name": "CHEK1 phosphorylates RAD51", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10555852", "map_id": "Q95Q25", "name": "rad-51", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00004297", "map_id": "WBGene00004297", "name": "rad-51", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10555855", "map_id": "Q95Q25", "name": "phospho-rad-51", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10503589", "map_id": "none", "name": "(S)-Malate + NAD+ <=> Oxaloacetate + NADH + H+", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_113587", "map_id": "CHEBI:30744", "name": "OAA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10503586", "map_id": "none", "name": "MDH2 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "O02640", "map_id": "O02640", "name": "mdh-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003162", "map_id": "WBGene00003162", "name": "mdh-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10504295", "map_id": "none", "name": "GDP + Orthophosphate + Succinyl-CoA <=> GTP + Succinate + CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_70958", "map_id": "CHEBI:57292", "name": "SUCC-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10504292", "map_id": "none", "name": "SUCLG1:SUCLG2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "P53596", "map_id": "P53596", "name": "sucl-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007350", "map_id": "WBGene00007350", "name": "sucl-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P53589", "map_id": "P53589", "name": "sucg-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016844", "map_id": "WBGene00016844", "name": "sucg-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10503561", "map_id": "none", "name": "isocitrate + NAD+ => alpha-ketoglutarate + CO2 + NADH + H+ [IDH3]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_29938", "map_id": "CHEBI:151", "name": "ISCIT", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10503558", "map_id": "none", "name": "IDH3 complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q20049", "map_id": "Q20049", "name": "idhg-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009440", "map_id": "WBGene00009440", "name": "idhg-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q93714", "map_id": "Q93714", "name": "idha-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009664", "map_id": "WBGene00009664", "name": "idha-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q93353", "map_id": "Q93353", "name": "idhb-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007993", "map_id": "WBGene00007993", "name": "idhb-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10525994", "map_id": "none", "name": "NADPH + NAD+ + H+ [cytosol] => NADP+ + NADH + H+ [mitochondrial matrix]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5462", "compartment_display": "mitochondrion" }, { "id": "species_10525991", "map_id": "none", "name": "NNT dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "Q18031", "map_id": "Q18031", "name": "nnt-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003778", "map_id": "WBGene00003778", "name": "nnt-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10570923", "map_id": "none", "name": "ME3:Mg2+ tetramer oxidatively decarboxylates MAL to PYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10570920", "map_id": "none", "name": "ME3:Mg2+ tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q9U296", "map_id": "Q9U296", "name": "men-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012983", "map_id": "WBGene00012983", "name": "men-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10525996", "map_id": "none", "name": "isocitrate <=> citrate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10503566", "map_id": "P34455", "name": "aco-2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "WBGene00000041", "map_id": "WBGene00000041", "name": "aco-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10503628", "map_id": "none", "name": "Succinate <=> Fumarate (with FAD redox reaction on enzyme)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_113588", "map_id": "CHEBI:18012", "name": "FUMA", "type": "catalyst", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10503625", "map_id": "none", "name": "SDH complex (ox.)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "P41956", "map_id": "P41956", "name": "mev-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003225", "map_id": "WBGene00003225", "name": "mev-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q09508", "map_id": "Q09508", "name": "sdha-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00015391", "map_id": "WBGene00015391", "name": "sdha-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O62215", "map_id": "O62215", "name": "sdhd-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009353", "map_id": "WBGene00009353", "name": "sdhd-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q09545", "map_id": "Q09545", "name": "sdhb-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006433", "map_id": "WBGene00006433", "name": "sdhb-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10503599", "map_id": "none", "name": "Fumarate + H2O <=> (S)-Malate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10503596", "map_id": "none", "name": "FH tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "O17214", "map_id": "O17214", "name": "fum-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001503", "map_id": "WBGene00001503", "name": "fum-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10570899", "map_id": "none", "name": "ME2:Mg2+ tetramer oxidatively decarboxylates MAL to PYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10570896", "map_id": "none", "name": "ME2:Mg2+ tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "reaction_10503988", "map_id": "none", "name": "alpha-ketoglutarate + CoASH + NAD+ => succinyl-CoA + CO2 + NADH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10503711", "map_id": "none", "name": "lipo-aKGDH", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "O61199", "map_id": "O61199", "name": "ogdh-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020679", "map_id": "WBGene00020679", "name": "ogdh-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_8878387", "map_id": "CHEBI:58937", "name": "ThDP", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "CHEBI:17460", "map_id": "CHEBI:17460", "name": "CHEBI:17460", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O45148", "map_id": "O45148", "name": "dlst-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020950", "map_id": "WBGene00020950", "name": "dlst-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O17953", "map_id": "O17953", "name": "dld-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010794", "map_id": "WBGene00010794", "name": "dld-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10526006", "map_id": "none", "name": "isocitrate + NADP+ => alpha-ketoglutarate + CO2 + NADPH + H+ [IDH2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10526003", "map_id": "none", "name": "IDH2 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "O17643", "map_id": "O17643", "name": "idh-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007942", "map_id": "WBGene00007942", "name": "idh-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10503579", "map_id": "none", "name": "Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10503576", "map_id": "none", "name": "CS dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "P34575", "map_id": "P34575", "name": "cts-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000833", "map_id": "WBGene00000833", "name": "cts-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10503643", "map_id": "none", "name": "ADP + Orthophosphate + Succinyl-CoA <=> ATP + Succinate + CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10503640", "map_id": "none", "name": "SUCLA2:SUCLG1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "P53588", "map_id": "P53588", "name": "suca-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009812", "map_id": "WBGene00009812", "name": "suca-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10570874", "map_id": "none", "name": "FAHD1:Zn2+ dimer hydrolyses OA to PYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10570871", "map_id": "none", "name": "FAHD1:Mg2+ dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "P34673", "map_id": "P34673", "name": "fahd-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022798", "map_id": "WBGene00022798", "name": "fahd-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10528274", "map_id": "none", "name": "(R)-2-hydroxyglutarate + succinate semialdehyde <=> 2-oxoglutarate + 4-hydroxybutyrate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_879997", "map_id": "CHEBI:32796", "name": "2HG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_880041", "map_id": "CHEBI:16724", "name": "HBUT", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10528271", "map_id": "Q9U2M4", "name": "hphd-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "WBGene00012608", "map_id": "WBGene00012608", "name": "hphd-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10528292", "map_id": "none", "name": "(S)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane" }, { "id": "species_880013", "map_id": "CHEBI:32797", "name": "2HG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10528289", "map_id": "Q9N4Z0", "name": "L2HGDH", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "WBGene00021564", "map_id": "WBGene00021564", "name": "L2HGDH", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10528282", "map_id": "none", "name": "(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10528279", "map_id": "G5EE46", "name": "D2HGDH", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "WBGene00010055", "map_id": "WBGene00010055", "name": "D2HGDH", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_880067", "map_id": "CHEBI:29105", "name": "Zn2+", "type": "catalyst", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_113527", "map_id": "CHEBI:29035", "name": "Mn2+", "type": "catalyst", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10563171", "map_id": "none", "name": "LDHAL6B reduces PYR to LACT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_6807616", "map_id": "CHEBI:422", "name": "LACT", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10563168", "map_id": "Q27888", "name": "ldh-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "WBGene00002262", "map_id": "WBGene00002262", "name": "ldh-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10503986", "map_id": "none", "name": "lipo-PDH decarboxylates PYR to Ac-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10503983", "map_id": "none", "name": "lipo-PDH", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "P52899", "map_id": "P52899", "name": "PDHA1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011510", "map_id": "WBGene00011510", "name": "PDHA1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O44451", "map_id": "O44451", "name": "pdhb-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00015413", "map_id": "WBGene00015413", "name": "pdhb-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q19749", "map_id": "Q19749", "name": "dlat-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009082", "map_id": "WBGene00009082", "name": "dlat-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10557975", "map_id": "none", "name": "HAGH hydrolyses (R)-S-LGSH to GSH and LACT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5694130", "map_id": "CHEBI:15694", "name": "(R)-S-LGSH", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_29708", "map_id": "CHEBI:422", "name": "LACT", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10557972", "map_id": "none", "name": "HAGH-2:2xZn2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9XXJ1", "map_id": "Q9XXJ1", "name": "HAGH-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012459", "map_id": "WBGene00012459", "name": "HAGH-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10503144", "map_id": "none", "name": "LDH tetramer oxidises LACT to PYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10503141", "map_id": "none", "name": "LDH tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q27888", "map_id": "Q27888", "name": "ldh-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10570888", "map_id": "none", "name": "ME1:Mg2+ tetramer oxidatively decarboxylates MAL to PYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10570885", "map_id": "none", "name": "ME1:Mg2+ tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10570839", "map_id": "none", "name": "DCA binds PDK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_9010792", "map_id": "none", "name": "DCA", "type": "inhibitor", "sub_type": "other", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10515600", "map_id": "Q02332", "name": "pdhk-2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "WBGene00022719", "map_id": "WBGene00022719", "name": "pdhk-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10515607", "map_id": "none", "name": "DCA:PDK2", "type": "inhibitor", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q02332", "map_id": "Q02332", "name": "pdhk-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10515609", "map_id": "none", "name": "PDK isoforms phosphorylate lipo-PDH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10515593", "map_id": "none", "name": "p-lipo-PDH", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "species_10515598", "map_id": "Q02332", "name": "pdhk-2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10514503", "map_id": "none", "name": "RXRA:PPARD:atRA", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_5334816", "map_id": "CHEBI:15367", "name": "atRA", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "reaction_10570846", "map_id": "none", "name": "GSTZ1 dimer dehalogenates DCA to glyoxylate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_904849", "map_id": "CHEBI:16891", "name": "glyoxylate", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10570843", "map_id": "none", "name": "GSTZ1 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "reaction_10515983", "map_id": "none", "name": "PDP dephosphorylates p-lipo-PDH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10515980", "map_id": "none", "name": "PDP", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q9U300", "map_id": "Q9U300", "name": "pdpr-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013718", "map_id": "WBGene00013718", "name": "pdpr-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9N4M0", "map_id": "Q9N4M0", "name": "pdp-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022832", "map_id": "WBGene00022832", "name": "pdp-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10504332", "map_id": "none", "name": "LDH tetramer reduces PYR to LACT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10570926", "map_id": "none", "name": "VDAC1 transports PYR from cytosol to mitochondrial intermembrane space", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9012375", "map_id": "CHEBI:15361", "name": "PYR", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "false" }, { "id": "species_10550419", "map_id": "Q21752", "name": "vdac-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "false" }, { "id": "reaction_10532289", "map_id": "none", "name": "Methylthio-ribose-P = Methylthio-ribulose-P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1237165", "map_id": "CHEBI:58533", "name": "MTRIBP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_1237107", "map_id": "CHEBI:58548", "name": "MTRIBUP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10532286", "map_id": "Q93169", "name": "MRI1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00007236", "map_id": "WBGene00007236", "name": "MRI1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10532309", "map_id": "none", "name": "Acireductone is created", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1237176", "map_id": "CHEBI:58828", "name": "2,3-DMPP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_1237155", "map_id": "CHEBI:58795", "name": "Acireductone", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10532306", "map_id": "none", "name": "E1:Mg++", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q21012", "map_id": "Q21012", "name": "ENOPH1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010286", "map_id": "WBGene00010286", "name": "ENOPH1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10532299", "map_id": "none", "name": "Acireductone is oxidized to MOB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1237122", "map_id": "CHEBI:16723", "name": "4MTOBUTA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10532296", "map_id": "none", "name": "ARD:Fe++", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q20340", "map_id": "Q20340", "name": "ADI1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009636", "map_id": "WBGene00009636", "name": "ADI1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10532319", "map_id": "none", "name": "MTA is cleaved and phosphorylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10532316", "map_id": "none", "name": "MTAP trimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q09438", "map_id": "Q09438", "name": "MTAP", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00015064", "map_id": "WBGene00015064", "name": "MTAP", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10510738", "map_id": "none", "name": "FA anion flip-flops to the opposite surface", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane" }, { "id": "species_10510733", "map_id": "none", "name": "FA anion:UCP dimer \"head-in\" complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "species_166216", "map_id": "CHEBI:28868", "name": "Fatty Acid anion \"head-out\"", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "O01883", "map_id": "O01883", "name": "ucp-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006729", "map_id": "WBGene00006729", "name": "ucp-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10510735", "map_id": "none", "name": "FA anion:UCP dimer \"head-out\" complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "reaction_10510740", "map_id": "none", "name": "FA anion diffuses laterally to UCP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane" }, { "id": "species_10510731", "map_id": "none", "name": "UCP dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "species_166213", "map_id": "CHEBI:28868", "name": "Fatty Acid anion \"head-in\"", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "reaction_10510742", "map_id": "none", "name": "The FA anion diffuses away laterally from UCP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane" }, { "id": "reaction_10511077", "map_id": "none", "name": "Protons are translocated from the intermembrane space to the matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane" }, { "id": "species_163953", "map_id": "CHEBI:15378", "name": "H+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "false" }, { "id": "species_30495", "map_id": "CHEBI:15904", "name": "LCFA", "type": "catalyst", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_170037", "map_id": "none", "name": "Purine nucleotide", "type": "inhibitor", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10567812", "map_id": "none", "name": "RUNX3 binds SMAD3 and SMAD4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10567808", "map_id": "none", "name": "p-2S-SMAD3:p-2S-SMAD3:SMAD4", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10567810", "map_id": "none", "name": "RUNX3:p-2S-SMAD3:p-2S-SMAD3:SMAD4", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10567805", "map_id": "none", "name": "RUNX3 binds ZFHX3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10567801", "map_id": "V6CLN5", "name": "zfh-2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00022518", "map_id": "WBGene00022518", "name": "zfh-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10567803", "map_id": "none", "name": "RUNX3:ZFHX3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "V6CLN5", "map_id": "V6CLN5", "name": "zfh-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10520769", "map_id": "none", "name": "hexacosanoyl-CoA + O2 => trans-2,3-dehydrohexacosanoyl-CoA + H2O2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_390260", "map_id": "CHEBI:52966", "name": "C26:0 CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_390249", "map_id": "CHEBI:52975", "name": "trans-2,3-dehydrohexacosanoyl-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "reaction_10520758", "map_id": "none", "name": "HSD17B4 dehydrogenates 3-hydroxyhexacosanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_390248", "map_id": "CHEBI:64972", "name": "3-hydroxyhexacosanoyl-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_390241", "map_id": "CHEBI:52977", "name": "3-ketohexacosanoyl-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "reaction_10520808", "map_id": "none", "name": "Peroxisomal uptake of very long-chain fatty acyl CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane" }, { "id": "species_390394", "map_id": "CHEBI:52966", "name": "C26:0 CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10520381", "map_id": "none", "name": "ABCD1 homodimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane", "complex": "true" }, { "id": "O45730", "map_id": "O45730", "name": "pmp-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10520760", "map_id": "none", "name": "HSD17B4 hydrates trans-2,3-dehydrohexacosanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "reaction_10563641", "map_id": "none", "name": "EHHADH hydrates trans-2,3-dehydrohexacosanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_10563638", "map_id": "O17761", "name": "ech-8", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "WBGene00001157", "map_id": "WBGene00001157", "name": "ech-8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10556490", "map_id": "none", "name": "Peroxisomal ACOT4,6,8 hydrolyse MCFA-CoA, LCFA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_5690520", "map_id": "none", "name": "MCFA-CoA, LCFA-CoA", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "true" }, { "id": "species_164991", "map_id": "CHEBI:33184", "name": "LCFA-CoA", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_5690542", "map_id": "CHEBI:61907", "name": "MCFA-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_5690539", "map_id": "none", "name": "MCFA, LCFA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "true" }, { "id": "species_5690531", "map_id": "CHEBI:59554", "name": "MCFA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_174602", "map_id": "CHEBI:15904", "name": "LCFAs", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10556487", "map_id": "none", "name": "ACOT4,6,8", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "true" }, { "id": "O45003", "map_id": "O45003", "name": "ACOT2(1-483)", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020989", "map_id": "WBGene00020989", "name": "ACOT2(1-483)", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9GYN3", "map_id": "Q9GYN3", "name": "ACOT2(1-483)", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "B3WFZ3", "map_id": "B3WFZ3", "name": "ACOT2(1-483)", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O01862", "map_id": "O01862", "name": "ACOT2(1-483)", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9BIA9", "map_id": "Q9BIA9", "name": "ACOT8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10530620", "map_id": "none", "name": "malonyl-CoA is decarboxylated to acetyl-CoA in peroxisome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_977323", "map_id": "CHEBI:15531", "name": "Malonyl-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_389536", "map_id": "CHEBI:16526", "name": "CO2", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_10530617", "map_id": "Q20048", "name": "mlcd-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "WBGene00009439", "map_id": "WBGene00009439", "name": "mlcd-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10563644", "map_id": "none", "name": "EHHADH dehydrogenates 3-hydroxyhexacosanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "reaction_10520641", "map_id": "none", "name": "pristanate + CoA-SH + ATP => pristanoyl-CoA + AMP + pyrophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_6811612", "map_id": "CHEBI:77268", "name": "pristanate", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_389573", "map_id": "CHEBI:30616", "name": "ATP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_389593", "map_id": "CHEBI:29888", "name": "PPi", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_389620", "map_id": "CHEBI:16027", "name": "AMP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_10520635", "map_id": "none", "name": "Homologues of SLC27A2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane", "complex": "true" }, { "id": "reaction_10520629", "map_id": "none", "name": "2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_389594", "map_id": "CHEBI:15475", "name": "3S2HPhy-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_389578", "map_id": "CHEBI:15522", "name": "FOR-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_389636", "map_id": "CHEBI:49189", "name": "Pristanal", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_10520626", "map_id": "none", "name": "HACL1 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "true" }, { "id": "Q17474", "map_id": "Q17474", "name": "HACL1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007143", "map_id": "WBGene00007143", "name": "HACL1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10520617", "map_id": "none", "name": "ALDH3A2-2 oxidizes pristanal to pristanate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_10520614", "map_id": "none", "name": "ALDH3A2-2 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane", "complex": "true" }, { "id": "reaction_10520651", "map_id": "none", "name": "phytanoyl-CoA + 2-oxoglutarate + O2 => 2-hydroxyphytanoyl-CoA + succinate + CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_389615", "map_id": "CHEBI:15538", "name": "Phytanoyl-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_389537", "map_id": "CHEBI:16810", "name": "2OG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_389583", "map_id": "CHEBI:30031", "name": "SUCCA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_10520648", "map_id": "none", "name": "PHYH:Fe++", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "true" }, { "id": "O62515", "map_id": "O62515", "name": "PHYH", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00014000", "map_id": "WBGene00014000", "name": "PHYH", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10520638", "map_id": "none", "name": "phytanate + CoA-SH + ATP => phytanoyl-CoA + AMP + pyrophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_389596", "map_id": "CHEBI:16285", "name": "Phytanate", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "reaction_10564665", "map_id": "none", "name": "ACBD4,5 bind MCFA-CoA and LCFA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane" }, { "id": "species_10564661", "map_id": "none", "name": "ACBD5,(ACBD4)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane", "complex": "true" }, { "id": "A0A1D3PCN1", "map_id": "A0A1D3PCN1", "name": "ACBD5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00270319", "map_id": "WBGene00270319", "name": "ACBD5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XTZ5", "map_id": "Q9XTZ5", "name": "maa-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007680", "map_id": "WBGene00007680", "name": "maa-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10564663", "map_id": "none", "name": "ACBD4,5:LCFA-CoA, MCFA-CoA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane", "complex": "true" }, { "id": "reaction_10558271", "map_id": "none", "name": "HAO2 tetramer oxidises 2OH-PALM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_6787810", "map_id": "CHEBI:65101", "name": "2OH-PALM", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_6787814", "map_id": "CHEBI:86988", "name": "2oxo-PALM", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_10558268", "map_id": "none", "name": "HAO2 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "true" }, { "id": "B1GRK5", "map_id": "B1GRK5", "name": "HAO1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018286", "map_id": "WBGene00018286", "name": "HAO1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10563806", "map_id": "none", "name": "NUDT19 hydrolyses acyl-CoA to 3',5'-ADP and acyl-PPANT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_6810523", "map_id": "CHEBI:37554", "name": "FA-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_6809360", "map_id": "CHEBI:37240", "name": "3',5'-ADP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_6810530", "map_id": "CHEBI:47983", "name": "acyl-PPANT", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_10563803", "map_id": "P91148", "name": "ndx-7", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "WBGene00003584", "map_id": "WBGene00003584", "name": "ndx-7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10516209", "map_id": "none", "name": "GTP-bound RAC contributes to JNK activation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10516065", "map_id": "none", "name": "RAC1:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10516179", "map_id": "none", "name": "p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10516063", "map_id": "none", "name": "RAC1:GDP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10513418", "map_id": "none", "name": "Active JNK moves to the nucleus and phosphorylates different transcription factors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13231", "compartment_display": "nuclear envelope" }, { "id": "species_10510872", "map_id": "Q8WQG9", "name": "phospho-jnk-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10523262", "map_id": "none", "name": "Gq activation by TP receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10523257", "map_id": "none", "name": "TP receptor:Thromboxane A2:G-protein Gq (inactive)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10523259", "map_id": "none", "name": "TP receptor:Thromboxane A2:G-protein Gq (active)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10523342", "map_id": "none", "name": "G13 activation by TP receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10523337", "map_id": "none", "name": "TP receptor:Thromboxane A2:G-protein G13 (inactive)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10523339", "map_id": "none", "name": "TP receptor:Thromboxane A2:G-protein G13 (active)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10546012", "map_id": "none", "name": "Conjugation of SUMO1 to UBA2:SAE1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10546368", "map_id": "none", "name": "SMC5-SMC6 Complex SUMOylates Cohesin with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10544476", "map_id": "none", "name": "Cohesin Complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10546332", "map_id": "none", "name": "SUMOylated Cohesin", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10546365", "map_id": "none", "name": "SMC5-SMC6 Complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "G5EG17", "map_id": "G5EG17", "name": "smc-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010056", "map_id": "WBGene00010056", "name": "smc-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P91501", "map_id": "P91501", "name": "NSMCE1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020843", "map_id": "WBGene00020843", "name": "NSMCE1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q23420", "map_id": "Q23420", "name": "NSMCE2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022881", "map_id": "WBGene00022881", "name": "NSMCE2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XTV3", "map_id": "Q9XTV3", "name": "EID3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010409", "map_id": "WBGene00010409", "name": "EID3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q18237", "map_id": "Q18237", "name": "smc-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016151", "map_id": "WBGene00016151", "name": "smc-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10549336", "map_id": "none", "name": "SUMOylation of MDC1 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10549326", "map_id": "Q9U370", "name": "pis-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00004031", "map_id": "WBGene00004031", "name": "pis-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10549334", "map_id": "none", "name": "SUMO1:MDC1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9U370", "map_id": "Q9U370", "name": "pis-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10549321", "map_id": "none", "name": "SUMOylation of XPC with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10549311", "map_id": "Q9N4C3", "name": "xpc-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00022296", "map_id": "WBGene00022296", "name": "xpc-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10549319", "map_id": "none", "name": "SUMO1:XPC", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9N4C3", "map_id": "Q9N4C3", "name": "xpc-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10546235", "map_id": "none", "name": "UBE2I, HDAC7 SUMOylate PML with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10546225", "map_id": "none", "name": "3SUMO1:PML", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "G5ED20", "map_id": "G5ED20", "name": "tam-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10546232", "map_id": "none", "name": "UBE2I,HDAC7", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "O17323", "map_id": "O17323", "name": "hda-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001837", "map_id": "WBGene00001837", "name": "hda-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10549243", "map_id": "none", "name": "PIAS4 SUMOylates RNF168 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10549233", "map_id": "Q7YWU1", "name": "RNF168", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00011366", "map_id": "WBGene00011366", "name": "SUMO1-RNF168", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10549241", "map_id": "none", "name": "SUMO1:RNF168", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q7YWU1", "map_id": "Q7YWU1", "name": "SUMO1-RNF168", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10546173", "map_id": "none", "name": "PIAS1,4 SUMOylates BRCA1 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10546154", "map_id": "B6VQ60", "name": "brc-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00000264", "map_id": "WBGene00000264", "name": "brc-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10546162", "map_id": "none", "name": "SUMO1:BRCA1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "B6VQ60", "map_id": "B6VQ60", "name": "brc-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10546170", "map_id": "none", "name": "PIAS1,4", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10549255", "map_id": "none", "name": "PIAS4 SUMOylates VHL with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10532238", "map_id": "Q19213", "name": "vhl-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00006922", "map_id": "WBGene00006922", "name": "vhl-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10549253", "map_id": "none", "name": "3SUMO1:VHL", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q19213", "map_id": "Q19213", "name": "vhl-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10546769", "map_id": "none", "name": "PIAS1 SUMOylates SP3 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10546758", "map_id": "Q9XW26", "name": "sptf-3", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10546766", "map_id": "none", "name": "SUMO1:SP3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10546189", "map_id": "none", "name": "PIAS4 SUMOylates TP53BP1 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10546178", "map_id": "Q7JKP6", "name": "hsr-9", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00002027", "map_id": "WBGene00002027", "name": "hsr-9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10546186", "map_id": "none", "name": "SUMO1:TP53BP1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q7JKP6", "map_id": "Q7JKP6", "name": "hsr-9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10546734", "map_id": "none", "name": "PIAS3 SUMOylates MITF with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10546716", "map_id": "H2KZZ2", "name": "hlh-30", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00020930", "map_id": "WBGene00020930", "name": "hlh-30", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10546725", "map_id": "none", "name": "2SUMO1:MITF", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "H2KZZ2", "map_id": "H2KZZ2", "name": "hlh-30", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10546731", "map_id": "none", "name": "Homologues of PIAS3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10549296", "map_id": "none", "name": "SUMOylation of NOP58 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10549285", "map_id": "O45012", "name": "nol-58", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10549294", "map_id": "none", "name": "2SUMO1:NOP58", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10548368", "map_id": "none", "name": "SUMOylation of DDX5 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10504695", "map_id": "Q9XUW5", "name": "ddx-17", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10548366", "map_id": "none", "name": "SUMO1:DDX5", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10548945", "map_id": "none", "name": "PIAS2-1 SUMOylates PARK7 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10548932", "map_id": "P90994", "name": "djr-1.1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10548940", "map_id": "none", "name": "SUMO1:PARK7", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10548961", "map_id": "none", "name": "PIAS1 SUMOylates SAFB with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10548950", "map_id": "O62203", "name": "phm-2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00009314", "map_id": "WBGene00009314", "name": "phm-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10548959", "map_id": "none", "name": "2SUMO1:SAFB", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "O62203", "map_id": "O62203", "name": "phm-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10549026", "map_id": "none", "name": "SUMOylation of HIPK2 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10549016", "map_id": "Q8MQ70", "name": "hpk-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00001994", "map_id": "WBGene00001994", "name": "hpk-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10549024", "map_id": "none", "name": "SUMO1:HIPK2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q8MQ70", "map_id": "Q8MQ70", "name": "hpk-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10548179", "map_id": "none", "name": "TRIM28 SUMOylates TRIM28:ZNF350 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10548151", "map_id": "none", "name": "TRIM28:ZNF350", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9N5S3", "map_id": "Q9N5S3", "name": "lsy-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003087", "map_id": "WBGene00003087", "name": "lsy-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O46016", "map_id": "O46016", "name": "klu-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013970", "map_id": "WBGene00013970", "name": "klu-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "B7WNA2", "map_id": "B7WNA2", "name": "ZNF350", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010264", "map_id": "WBGene00010264", "name": "ZNF350", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q19418", "map_id": "Q19418", "name": "ztf-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008762", "map_id": "WBGene00008762", "name": "ztf-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "H2L008", "map_id": "H2L008", "name": "ztf-16", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019960", "map_id": "WBGene00019960", "name": "ztf-16", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9BLC4", "map_id": "Q9BLC4", "name": "sdz-12", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017406", "map_id": "WBGene00017406", "name": "sdz-12", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O02050", "map_id": "O02050", "name": "klu-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022592", "map_id": "WBGene00022592", "name": "klu-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "H2L0K3", "map_id": "H2L0K3", "name": "nhl-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003599", "map_id": "WBGene00003599", "name": "nhl-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q19818", "map_id": "Q19818", "name": "nhl-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003598", "map_id": "WBGene00003598", "name": "nhl-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10548176", "map_id": "none", "name": "SUMO1:TRIM28:ZNF350", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10529660", "map_id": "none", "name": "Homologues of TRIM28", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10548358", "map_id": "none", "name": "SUMOylation of DDX17 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10548348", "map_id": "Q9XUW5", "name": "ddx-17", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10548356", "map_id": "none", "name": "SUMO1:DDX17", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10548346", "map_id": "none", "name": "SUMOylation of EP300 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10548344", "map_id": "none", "name": "2SUMO1:EP300", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10549506", "map_id": "none", "name": "SUMOylation of TOP1 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10549496", "map_id": "O17966", "name": "top-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00006595", "map_id": "WBGene00006595", "name": "top-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10549504", "map_id": "none", "name": "SUMO1:TOP1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "O17966", "map_id": "O17966", "name": "top-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10549491", "map_id": "none", "name": "SUMOylation of TOP2B with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10549474", "map_id": "none", "name": "Homologues of TOP2B", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q23670", "map_id": "Q23670", "name": "top-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010785", "map_id": "WBGene00010785", "name": "top-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5ECQ8", "map_id": "G5ECQ8", "name": "cin-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022854", "map_id": "WBGene00022854", "name": "cin-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34534", "map_id": "P34534", "name": "SUMO1-K-TOP2B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019884", "map_id": "WBGene00019884", "name": "SUMO1-K-TOP2B", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10549489", "map_id": "none", "name": "SUMO1:TOP2B", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10549460", "map_id": "none", "name": "SUMOylation of TOP2A with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10549450", "map_id": "P34534", "name": "TOP2A", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10549458", "map_id": "none", "name": "SUMO1:TOP2A", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10549415", "map_id": "none", "name": "SUMOylation of PCNA with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10502651", "map_id": "O02115", "name": "pcn-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10549413", "map_id": "none", "name": "SUMO1:PCNA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10548917", "map_id": "none", "name": "SUMOylation of PIAS4 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10548915", "map_id": "none", "name": "SUMO1:PIAS4", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10548971", "map_id": "none", "name": "SUMOylation of UBE2I with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10548969", "map_id": "none", "name": "SUMO1:K14-UBE2I", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10546255", "map_id": "none", "name": "UBC9 (UBE2I) SUMOylates RANGAP1 with SUMO, which targets RANGAP1 to RANBP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13231", "compartment_display": "nuclear envelope" }, { "id": "species_10546242", "map_id": "none", "name": "RANGAP1 homodimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_13231", "compartment_display": "nuclear envelope", "complex": "true" }, { "id": "P34342", "map_id": "P34342", "name": "ran-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004303", "map_id": "WBGene00004303", "name": "ran-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10546252", "map_id": "none", "name": "SUMO1:RANGAP1 homodimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_13231", "compartment_display": "nuclear envelope", "complex": "true" }, { "id": "reaction_10509888", "map_id": "none", "name": "Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a 'closed-loop' conformation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10505614", "map_id": "Q9TXU7", "name": "eif-1.a", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00019162", "map_id": "WBGene00019162", "name": "eif-1.a", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10509884", "map_id": "Q9U302", "name": "pab-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10509879", "map_id": "none", "name": "Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10505637", "map_id": "none", "name": "43S complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9BKU3", "map_id": "Q9BKU3", "name": "eif-2alpha", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021351", "map_id": "WBGene00021351", "name": "eif-2alpha", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q21230", "map_id": "Q21230", "name": "eif-2beta", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010560", "map_id": "WBGene00010560", "name": "eif-2beta", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q95XR0", "map_id": "Q95XR0", "name": "eif-2gamma", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021466", "map_id": "WBGene00021466", "name": "eif-2gamma", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q95QW0", "map_id": "Q95QW0", "name": "eif-3.L", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00015920", "map_id": "WBGene00015920", "name": "eif-3.L", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O01974", "map_id": "O01974", "name": "eif-3.H", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001231", "map_id": "WBGene00001231", "name": "eif-3.H", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q94261", "map_id": "Q94261", "name": "cif-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019543", "map_id": "WBGene00019543", "name": "cif-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34339", "map_id": "P34339", "name": "egl-45", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001209", "map_id": "WBGene00001209", "name": "egl-45", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XWP7", "map_id": "Q9XWP7", "name": "eif-3.j", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012738", "map_id": "WBGene00012738", "name": "eif-3.j", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P30642", "map_id": "P30642", "name": "eif-3.D", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001227", "map_id": "WBGene00001227", "name": "eif-3.D", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q965S8", "map_id": "Q965S8", "name": "eif-3.I", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001232", "map_id": "WBGene00001232", "name": "eif-3.I", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O02328", "map_id": "O02328", "name": "eif-3.C", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001226", "map_id": "WBGene00001226", "name": "eif-3.C", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q19706", "map_id": "Q19706", "name": "eif-3.G", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001230", "map_id": "WBGene00001230", "name": "eif-3.G", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O61820", "map_id": "O61820", "name": "eif-3.E", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001228", "map_id": "WBGene00001228", "name": "eif-3.E", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q18967", "map_id": "Q18967", "name": "eif-3.F", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001229", "map_id": "WBGene00001229", "name": "eif-3.F", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XUP3", "map_id": "Q9XUP3", "name": "eif-3.K", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001233", "map_id": "WBGene00001233", "name": "eif-3.K", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XWI6", "map_id": "Q9XWI6", "name": "eif-3.B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001225", "map_id": "WBGene00001225", "name": "eif-3.B", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9TXU7", "map_id": "Q9TXU7", "name": "eif-1.a", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10509886", "map_id": "none", "name": "43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10509927", "map_id": "none", "name": "Formation of translation initiation complexes containing mRNA that does not circularize", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10509925", "map_id": "none", "name": "mRNA:eIF4F:eIF4B:eIF4H", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10505676", "map_id": "none", "name": "48S complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10549921", "map_id": "none", "name": "WNT5A-FZD4 recruits DVL2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10549898", "map_id": "none", "name": "N4GlycoAsn-PalmS-WNT5A:FZD4", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "P34889", "map_id": "P34889", "name": "cwn-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000858", "map_id": "WBGene00000858", "name": "cwn-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10515048", "map_id": "none", "name": "Homologues of DVL2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10549902", "map_id": "none", "name": "WNT5A:FZD4:DVL2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10549909", "map_id": "none", "name": "DVL2 is phosphorylated by PKC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10549904", "map_id": "none", "name": "WNT5A:FZD4:p-DVL2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10549906", "map_id": "none", "name": "Activated Protein kinase C (alpha, beta, gamma isoforms)", "type": "catalyst", "sub_type": "", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10549900", "map_id": "none", "name": "WNT5A binds FZD4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10546954", "map_id": "P34889", "name": "cwn-2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10548869", "map_id": "none", "name": "Homologues of FZD4", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10549919", "map_id": "none", "name": "p-DVL2 recruits AP-2 and beta-arrestin 2 to promote clathrin-mediated endocytosis", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10521727", "map_id": "P51485", "name": "arr-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00000195", "map_id": "WBGene00000195", "name": "arr-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10549913", "map_id": "none", "name": "clathrin:AP-2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10549917", "map_id": "none", "name": "WNT5A:FZD4:p-DVL2:ARRB2:AP-2:clathrin", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "P51485", "map_id": "P51485", "name": "arr-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10549967", "map_id": "none", "name": "WNT5A:FZD4 is endocytosed", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20592", "compartment_display": "clathrin-coated endocytic vesicle" }, { "id": "species_10549965", "map_id": "none", "name": "WNT5A:FZD4:p-DVL2:AP-2:clathrin", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_24339", "compartment_display": "clathrin-coated endocytic vesicle membrane", "complex": "true" }, { "id": "reaction_10548310", "map_id": "none", "name": "DVL is recruited to the receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10548306", "map_id": "none", "name": "p-DVL", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10548304", "map_id": "none", "name": "WNT:FZD", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q27886", "map_id": "Q27886", "name": "lin-44", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003029", "map_id": "WBGene00003029", "name": "lin-44", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q10459", "map_id": "Q10459", "name": "mom-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003395", "map_id": "WBGene00003395", "name": "mom-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10548308", "map_id": "none", "name": "WNT:FZD:pDVL", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10548294", "map_id": "none", "name": "ppDVL recruits RAC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10548288", "map_id": "none", "name": "RAC:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10548292", "map_id": "none", "name": "pp-DVL:RAC:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10549994", "map_id": "none", "name": "FZD2, FZD5 and ROR2 are internalized in a WNT5A and clathrin-dependent manner", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20592", "compartment_display": "clathrin-coated endocytic vesicle" }, { "id": "species_10549978", "map_id": "none", "name": "WNT5A:FZDs/ROR", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "G5EGK5", "map_id": "G5EGK5", "name": "cam-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000289", "map_id": "WBGene00000289", "name": "cam-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10549992", "map_id": "none", "name": "WNT5A:FZDs/ROR", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_24339", "compartment_display": "clathrin-coated endocytic vesicle membrane", "complex": "true" }, { "id": "reaction_10549980", "map_id": "none", "name": "WNT5A binds FZD and ROR receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10549976", "map_id": "none", "name": "FZD2/FZD5/ROR2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10549896", "map_id": "none", "name": "WNT5A binding to FZD promotes PRICKLE1 degradation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10549892", "map_id": "none", "name": "WNT5A-binding FZDs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10549894", "map_id": "none", "name": "WNT5A:FZD", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10549370", "map_id": "none", "name": "PRICKLE1 is degraded by the proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10549368", "map_id": "none", "name": "Homologues of ub-PRICKLE1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "H2KYA1", "map_id": "H2KYA1", "name": "prkl-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022727", "map_id": "WBGene00022727", "name": "prkl-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "H2KZA3", "map_id": "H2KZA3", "name": "pqn-22", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004112", "map_id": "WBGene00004112", "name": "pqn-22", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q17525", "map_id": "Q17525", "name": "tes-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00015217", "map_id": "WBGene00015217", "name": "tes-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10567373", "map_id": "none", "name": "GGA3 associates with activated MET receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10565510", "map_id": "Q23165", "name": "apt-9", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_171062", "compartment_display": "early endosome membrane", "complex": "false" }, { "id": "WBGene00000166", "map_id": "WBGene00000166", "name": "apt-9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10565557", "map_id": "none", "name": "ARF6:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_262783", "compartment_display": "recycling endosome membrane", "complex": "true" }, { "id": "Q9U2S4", "map_id": "Q9U2S4", "name": "arf-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000184", "map_id": "WBGene00000184", "name": "arf-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10567371", "map_id": "none", "name": "HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:GGA3:ARF6:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_262783", "compartment_display": "recycling endosome membrane", "complex": "true" }, { "id": "Q23165", "map_id": "Q23165", "name": "apt-9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10515028", "map_id": "none", "name": "Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10515006", "map_id": "none", "name": "WNT:FZD:LRP5/6:DVL:AXIN:GSK3B", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "G5EBV9", "map_id": "G5EBV9", "name": "phospho-p-LRP6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020481", "map_id": "WBGene00020481", "name": "phospho-p-LRP6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q22179", "map_id": "Q22179", "name": "phospho-lrx-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003075", "map_id": "WBGene00003075", "name": "phospho-lrx-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7JP80", "map_id": "Q7JP80", "name": "phospho-p-LRP6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10515025", "map_id": "none", "name": "WNT:FZD:p5S/T-LRP5/6:DVL:AXIN:GSK3B", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10535159", "map_id": "none", "name": "DVL recruits GSK3beta:AXIN1 to the receptor complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10514942", "map_id": "none", "name": "GSK3B:AXIN1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10515004", "map_id": "none", "name": "WNT:FZD:LRP5/6:DVL", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10551830", "map_id": "none", "name": "WNT3A stimulates the caveolin-dependent internalization of FZD5:p-LRP6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10551808", "map_id": "none", "name": "WNT3A:FZD5:p-LRP6:GSK3B:AXIN:CAV1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10551828", "map_id": "none", "name": "WNT3A:FZD5:p-LRP6:GSK3B:AXIN:CAV1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_171062", "compartment_display": "early endosome membrane", "complex": "true" }, { "id": "reaction_10507606", "map_id": "none", "name": "RNA Polymerase II Promoter Opening: First Transition", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10507432", "map_id": "none", "name": "pol II closed pre-initiation complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10507459", "map_id": "none", "name": "Addition of Nucleotides 5 through 9 on the growing Transcript", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10507442", "map_id": "none", "name": "pol II transcription complex containing 4 nucleotide long transcript", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10506516", "map_id": "none", "name": "TFIID", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10506433", "map_id": "none", "name": "TFIIA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10507457", "map_id": "none", "name": "pol II transcription complex containing 9 nucleotide long transcript", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10506528", "map_id": "none", "name": "TFIIE", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10504433", "map_id": "none", "name": "RNA Polymerase II (unphosphorylated):TFIIF complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10507444", "map_id": "none", "name": "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10507394", "map_id": "none", "name": "pol II transcription complex containing 3 Nucleotide long transcript", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10506438", "map_id": "O16991", "name": "ttb-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10508100", "map_id": "none", "name": "Addition of nucleotides 10 and 11 on the growing transcript: Third Transition", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10508098", "map_id": "none", "name": "pol II transcription complex containing 11 nucleotide long transcript", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10507397", "map_id": "none", "name": "Addition of the third nucleotide on the nascent transcript", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10572134", "map_id": "none", "name": "Unwinding of DNA for the Nascent Transcript: Second Transition", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10572136", "map_id": "none", "name": "Unwinding DNA for the nascent transcript", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10508830", "map_id": "none", "name": "Addition of nucleotides between position +11 and +30", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10508135", "map_id": "none", "name": "Pol II transcription complex containing extruded transcript to +30", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10547360", "map_id": "none", "name": "GBE1 catalyzes branch formation in polyGlc-GYG2 complexed with GYS2-a", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10547348", "map_id": "none", "name": "polyGlc-GYG2:GYS2-a tetramer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9U2D9", "map_id": "Q9U2D9", "name": "phospho-gsy-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001793", "map_id": "WBGene00001793", "name": "phospho-gsy-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5ECZ5", "map_id": "G5ECZ5", "name": "oligo((1,4)-alpha-glycosyl) GYG2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011684", "map_id": "WBGene00011684", "name": "oligo((1,4)-alpha-glycosyl) GYG2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O45819", "map_id": "O45819", "name": "gyg-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012020", "map_id": "WBGene00012020", "name": "gyg-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10547358", "map_id": "none", "name": "glycogen-GYG2:GYS2-a tetramer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10547328", "map_id": "Q22137", "name": "GBE1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00011409", "map_id": "WBGene00011409", "name": "GBE1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10547331", "map_id": "none", "name": "GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-a", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10547303", "map_id": "none", "name": "polyGlc-GYG1:GYS1-a tetramer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10547323", "map_id": "none", "name": "glycogen-GYG1:GYS1-a tetramer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10547369", "map_id": "none", "name": "Autoglucosylation of GYG2 complexed with GYS2-b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10547364", "map_id": "none", "name": "GYG2:GYS2-b tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10547366", "map_id": "none", "name": "oligoGlc-GYG2:GYS2-b tetramer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10502858", "map_id": "none", "name": "PGM:Mg2+ isomerise G6P to G1P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10502855", "map_id": "none", "name": "PGM:Mg2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10547306", "map_id": "none", "name": "GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10547301", "map_id": "none", "name": "oligoGlc-GYG1:GYS1-a tetramer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10547374", "map_id": "none", "name": "Autoglucosylation of GYG1 complexed with GYS1-a", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10547371", "map_id": "none", "name": "GYG1:GYS1-a tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10547379", "map_id": "none", "name": "Phosphorylated GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10547315", "map_id": "none", "name": "oligoGlc-GYG1:GYS1-b tetramer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10547376", "map_id": "none", "name": "polyGlc-GYG1:GYS1-b tetramer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10547318", "map_id": "none", "name": "Autoglucosylation of GYG1 complexed with GYS1-b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10547313", "map_id": "none", "name": "GYG1:GYS1-b tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10547351", "map_id": "none", "name": "GYS2 catalyzes the polyglucosylation of oligoGlc-GYG2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10547346", "map_id": "none", "name": "oligoGlc-GYG2:GYS2-a tetramer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10547383", "map_id": "none", "name": "GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10547381", "map_id": "none", "name": "glycogen-GYG1:GYS1-b tetramer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10572378", "map_id": "none", "name": "PGM1:Mg2+ isomerises G1P to G6P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10572375", "map_id": "none", "name": "PGM1:Mg2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10547356", "map_id": "none", "name": "Autoglucosylation of GYG2 complexed with GYS2-a", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10547353", "map_id": "none", "name": "GYG2:GYS2-a tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10569064", "map_id": "none", "name": "TSPO:BZRAP1 transports CHOL from outer mitochondrial membrane to inner mitochondrial membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_8951853", "map_id": "CHEBI:16113", "name": "CHOL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "false" }, { "id": "species_193156", "map_id": "CHEBI:16113", "name": "CHOL", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "species_10569061", "map_id": "none", "name": "TSPO:BZRAP1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "true" }, { "id": "C7FZU5", "map_id": "C7FZU5", "name": "TSPO", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00077771", "map_id": "WBGene00077771", "name": "TSPO", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10513657", "map_id": "none", "name": "Reduction of isocaproaldehyde to 4-methylpentan-1-ol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_196095", "map_id": "CHEBI:17998", "name": "ISCAL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_196066", "map_id": "CHEBI:63910", "name": "MePeOH", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10513654", "map_id": "P91020", "name": "AKR1B1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10556977", "map_id": "none", "name": "HSD17B11 dehydrogenates EST17b to E1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_193132", "map_id": "CHEBI:16469", "name": "EST17b", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10556974", "map_id": "none", "name": "Homologues of HSD17B11", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10557699", "map_id": "none", "name": "AKR1B15 reduces EST17b to E1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_5696835", "map_id": "CHEBI:16469", "name": "EST17b", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_5696848", "map_id": "CHEBI:17263", "name": "E1", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10557696", "map_id": "none", "name": "Homologues of AKR1B15", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "reaction_10513367", "map_id": "none", "name": "CYP19A1 hydroxylates TEST to EST17b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10565899", "map_id": "none", "name": "HSD17B2 oxidises estradiol (E2) to estrone (E1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10565896", "map_id": "none", "name": "Homologues of HSD17B2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "O01758", "map_id": "O01758", "name": "dhs-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000966", "map_id": "WBGene00000966", "name": "dhs-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O16881", "map_id": "O16881", "name": "dhs-16", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000979", "map_id": "WBGene00000979", "name": "dhs-16", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q20012", "map_id": "Q20012", "name": "dhs-20", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000983", "map_id": "WBGene00000983", "name": "dhs-20", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q20840", "map_id": "Q20840", "name": "drd-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018885", "map_id": "WBGene00018885", "name": "drd-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10533200", "map_id": "none", "name": "Corticosteroids bind to CBG in blood", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_1449707", "map_id": "none", "name": "Corticosteroids", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "CHEBI:27584", "map_id": "CHEBI:27584", "name": "CHEBI:27584", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:17026", "map_id": "CHEBI:17026", "name": "CHEBI:17026", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_193977", "map_id": "CHEBI:17650", "name": "CORT", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "CHEBI:16973", "map_id": "CHEBI:16973", "name": "CHEBI:16973", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10533196", "map_id": "none", "name": "Homologues of SERPINA6", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10533198", "map_id": "none", "name": "CBG:Corticosteroids", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10513471", "map_id": "none", "name": "HSD11B2,HSD11B1 dimer oxidise CORT to COR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_194035", "map_id": "CHEBI:16962", "name": "COR", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10513468", "map_id": "none", "name": "Homologues of HSD11B2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10573281", "map_id": "none", "name": "SRD5A2 dehydrogenates TEST to DHTEST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10573278", "map_id": "none", "name": "Homologues of SRD5A2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q19605", "map_id": "Q19605", "name": "SRD5A2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00014241", "map_id": "WBGene00014241", "name": "SRD5A2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q20344", "map_id": "Q20344", "name": "SRD5A1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009635", "map_id": "WBGene00009635", "name": "SRD5A1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q23431", "map_id": "Q23431", "name": "SRD5A2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10513365", "map_id": "none", "name": "HSD17B3-like proteins reducde ANDST to TEST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10513360", "map_id": "Q10130", "name": "dhs-5", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "reaction_10573284", "map_id": "none", "name": "SRD5A3 dehydrogenates TEST to DHTEST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10526217", "map_id": "none", "name": "SRD5A1 dehydrogenates TEST to DHTEST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10526214", "map_id": "Q20344", "name": "SRD5A1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "reaction_10567315", "map_id": "none", "name": "MET phosphorylates CBL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10567312", "map_id": "none", "name": "HGF:p-4Y-MET dimer:GRB2:CBL", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10567233", "map_id": "none", "name": "HGF:p-4Y-MET dimer:GRB2:p-Y-CBL", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10567305", "map_id": "none", "name": "MET binds LRIG1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10521542", "map_id": "Q9XVQ7", "name": "MET", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10567301", "map_id": "Q965M2", "name": "sma-10", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "WBGene00020649", "map_id": "WBGene00020649", "name": "sma-10", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10567303", "map_id": "none", "name": "MET:LRIG1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q965M2", "map_id": "Q965M2", "name": "sma-10", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10567321", "map_id": "none", "name": "EPS15 and HGS bind ubiquitinated MET", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10512223", "map_id": "none", "name": "EPS15:HGS:STAM", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10567317", "map_id": "none", "name": "HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-METdimer:p-Y-CBL):CIN85:endophillin,(MET:Ub-LRIG1)", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10567319", "map_id": "none", "name": "HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-METdimer:p-Y-CBL):CIN85:endophillin:EPS15:HGS:STAM,(MET:Ub-LRIG1:EPS15:HGS:STAM)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10567245", "map_id": "none", "name": "CBL monoubiquitinates activated MET", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10567242", "map_id": "none", "name": "HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10508741", "map_id": "none", "name": "REV1 inserts dCMP opposite to AP sites in DNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10508730", "map_id": "none", "name": "REV1:MonoUb:K164-PCNA:RPA:RFC:AP-DNA Template", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q09615", "map_id": "Q09615", "name": "rev-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00014066", "map_id": "WBGene00014066", "name": "rev-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10508738", "map_id": "none", "name": "REV1:MonoUb:K164-PCNA:RPA:RFC:(AP:Cyt)-DNA Template", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10508732", "map_id": "none", "name": "REV1 binds AP-dsDNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10508715", "map_id": "Q09615", "name": "rev-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10508728", "map_id": "none", "name": "MonoUb:K164-PCNA:RPA:RFC:AP-DNA Template", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10567136", "map_id": "none", "name": "STARD5 binds DCA, LCA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10567132", "map_id": "Q21130", "name": "STARD5", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00010505", "map_id": "WBGene00010505", "name": "STARD5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10567134", "map_id": "none", "name": "STARD5:DCA,LCA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q21130", "map_id": "Q21130", "name": "STARD5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10510001", "map_id": "none", "name": "Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_194096", "map_id": "none", "name": "cholate; chenodeoxycholate", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_194073", "map_id": "none", "name": "choloyl-CoA; chenodeoxycholoyl-CoA", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_192356", "map_id": "CHEBI:15519", "name": "choloyl-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_193472", "map_id": "CHEBI:28701", "name": "chenodeoxycholoyl-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_10509998", "map_id": "none", "name": "Homologues of SLC27A5", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10513491", "map_id": "none", "name": "SLC10A2 transports bile salts and acids and Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10513481", "map_id": "none", "name": "Homologues of FABP6", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_192483", "map_id": "none", "name": "bile salts and acids", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "CHEBI:17687", "map_id": "CHEBI:17687", "name": "CHEBI:17687", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:28865", "map_id": "CHEBI:28865", "name": "CHEBI:28865", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:36274", "map_id": "CHEBI:36274", "name": "CHEBI:36274", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:9407", "map_id": "CHEBI:9407", "name": "CHEBI:9407", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10513483", "map_id": "none", "name": "bile salts and acids:FABP6", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:16525", "map_id": "CHEBI:16525", "name": "CHEBI:16525", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10513488", "map_id": "Q33BL1", "name": "SLC10A2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "WBGene00044650", "map_id": "WBGene00044650", "name": "SLC10A2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10551492", "map_id": "none", "name": "NR1H4 binds DCA, CDCA, LCHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_5340249", "map_id": "none", "name": "DCA,CDCA,LCHA", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10519476", "map_id": "G5ECR9", "name": "unc-55", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10551490", "map_id": "none", "name": "NR1H4:DCA,CDCA,LCHA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10513382", "map_id": "none", "name": "ABCB11 transports bile salts from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_193416", "map_id": "none", "name": "bile salts", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_193479", "map_id": "none", "name": "bile salts", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10513379", "map_id": "none", "name": "Homologues of ABCB11", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "P34712", "map_id": "P34712", "name": "pgp-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003995", "map_id": "WBGene00003995", "name": "pgp-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EG58", "map_id": "G5EG58", "name": "pgp-9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004003", "map_id": "WBGene00004003", "name": "pgp-9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10510026", "map_id": "none", "name": "Cytosolic chenodeoxycholoyl-CoA or choloyl-CoA are conjugated with glycine or taurine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_194069", "map_id": "none", "name": "glycine; taurine", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:15891", "map_id": "CHEBI:15891", "name": "CHEBI:15891", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10510023", "map_id": "none", "name": "Homologues of BAAT", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10513424", "map_id": "none", "name": "Isomerization of 3,7,24THCA-CoA to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_193732", "map_id": "CHEBI:27403", "name": "3,7,24THCA-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "reaction_10513426", "map_id": "none", "name": "3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_193778", "map_id": "CHEBI:48736", "name": "3,7,24THCA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_193739", "map_id": "CHEBI:27403", "name": "3,7,24THCA-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10513398", "map_id": "none", "name": "Homologues of SLC27A2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10513428", "map_id": "none", "name": "4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_193724", "map_id": "CHEBI:63838", "name": "4CHOL7a,24(S)DONE", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_193760", "map_id": "CHEBI:63829", "name": "5beta-cholestan-7alpha,24(S)-diol-3-one", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10513222", "map_id": "none", "name": "Homologues of AKR1D1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10513430", "map_id": "none", "name": "4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_193745", "map_id": "CHEBI:63839", "name": "4CHOL7a,12a,24(S)TONE", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_193707", "map_id": "CHEBI:63830", "name": "5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10513432", "map_id": "none", "name": "5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_213285", "map_id": "CHEBI:63831", "name": "5beta-cholestan-3alpha,7alpha,24(S)-triol", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10513233", "map_id": "none", "name": "Homologues of AKR1C4", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10513434", "map_id": "none", "name": "Isomerization of 25(R) TetraHCA-CoA to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_193793", "map_id": "CHEBI:27458", "name": "25(R) TetraHCA-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_193422", "map_id": "CHEBI:52050", "name": "(24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "reaction_10513436", "map_id": "none", "name": "TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_193762", "map_id": "CHEBI:63824", "name": "TetraHCA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_193741", "map_id": "CHEBI:27458", "name": "25(R) TetraHCA-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10513420", "map_id": "none", "name": "3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10513438", "map_id": "none", "name": "5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_193728", "map_id": "CHEBI:63834", "name": "5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10513422", "map_id": "none", "name": "TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10513440", "map_id": "none", "name": "5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_193829", "map_id": "CHEBI:48834", "name": "5beta-cholestan-7alpha,12alpha,27-triol-3-one", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_193843", "map_id": "CHEBI:17278", "name": "5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10513442", "map_id": "none", "name": "4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9617026", "map_id": "CHEBI:48833", "name": "4CHOL7a,12a,27TONE", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "reaction_10513444", "map_id": "none", "name": "4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_193835", "map_id": "CHEBI:48825", "name": "4CHOL7a,27DONE", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_193830", "map_id": "CHEBI:48778", "name": "5beta-cholestan-7alpha,27-diol-3-one", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10513446", "map_id": "none", "name": "5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_193842", "map_id": "CHEBI:28540", "name": "5beta-cholestan-3alpha,7alpha,26-triol", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10513205", "map_id": "none", "name": "Cholesterol is hydroxylated to 25-hydroxycholesterol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_192148", "map_id": "CHEBI:42977", "name": "25OH-CHOL", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10513202", "map_id": "none", "name": "CH25H (Fe2+ cofactor)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q20027", "map_id": "Q20027", "name": "CH25H", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018036", "map_id": "WBGene00018036", "name": "CH25H", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10566516", "map_id": "none", "name": "OSBP exchanges 25OH-CHOL with PI4P from ER membrane to Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_8868399", "map_id": "CHEBI:42977", "name": "25OH-CHOL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_1806217", "map_id": "CHEBI:17526", "name": "PI4P", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "species_8868393", "map_id": "CHEBI:42977", "name": "25OH-CHOL", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "species_10566513", "map_id": "A7DTF2", "name": "obr-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00012930", "map_id": "WBGene00012930", "name": "obr-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10566397", "map_id": "none", "name": "OSBPs transport 25OH-CHOL from ER membrane to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_8868400", "map_id": "CHEBI:42977", "name": "25OH-CHOL", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10566394", "map_id": "none", "name": "OSBPs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q93485", "map_id": "Q93485", "name": "obr-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008832", "map_id": "WBGene00008832", "name": "obr-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O01686", "map_id": "O01686", "name": "obr-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016331", "map_id": "WBGene00016331", "name": "obr-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10513248", "map_id": "none", "name": "THCA is conjugated with Coenzyme A (SLC27A5 BACS)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_192013", "map_id": "CHEBI:18402", "name": "THCA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_192096", "map_id": "CHEBI:37642", "name": "25(R) THCA-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10513250", "map_id": "none", "name": "5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_191980", "map_id": "CHEBI:2290", "name": "5beta-cholestan-7alpha-ol-3-one", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_192030", "map_id": "CHEBI:28047", "name": "5beta-cholestan-3alpha,7alpha-diol", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10513410", "map_id": "none", "name": "(24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_192339", "map_id": "CHEBI:27379", "name": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "reaction_10513412", "map_id": "none", "name": "Chenodeoxycholoyl CoA reacts with glycine or taurine to form glycochenodeoxycholate or taurochenodeoxycholate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_193463", "map_id": "none", "name": "glycine; taurine", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "true" }, { "id": "species_193453", "map_id": "none", "name": "chenodeoxycholate bile salts", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "true" }, { "id": "species_10513260", "map_id": "none", "name": "Homologues of BAAT", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "true" }, { "id": "reaction_10513414", "map_id": "none", "name": "(24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_193403", "map_id": "CHEBI:28533", "name": "3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "reaction_10513384", "map_id": "none", "name": "25(S) DHCA-CoA is dehydrogenated to 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_193442", "map_id": "CHEBI:15494", "name": "25(S) DHCA-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_193459", "map_id": "CHEBI:27393", "name": "25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "reaction_10513416", "map_id": "none", "name": "25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA is hydrated to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "reaction_10513225", "map_id": "none", "name": "4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_192136", "map_id": "CHEBI:17899", "name": "4CHOL7aOLONE", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "reaction_10513263", "map_id": "none", "name": "Choloyl CoA reacts with glycine or taurine to form glycocholate or taurocholate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_193404", "map_id": "none", "name": "cholate bile salts", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "true" }, { "id": "reaction_10513392", "map_id": "none", "name": "Hydrolysis of choloyl-CoA to cholate and CoASH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "reaction_10513236", "map_id": "none", "name": "5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_192064", "map_id": "CHEBI:2288", "name": "5beta-cholesten-7alpha, 12alpha-diol-3-one", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_192087", "map_id": "CHEBI:16496", "name": "5beta-cholestan-3alpha,7alpha,12alpha-triol", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10513401", "map_id": "none", "name": "THCA is conjugated with Coenzyme A (SLC27A2 VLCS)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10513273", "map_id": "none", "name": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) is hydrated to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_192342", "map_id": "CHEBI:27505", "name": "THCA-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "reaction_10513403", "map_id": "none", "name": "DHCA is conjugated with Coenzyme A (SLC27A5 BACS)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_193505", "map_id": "CHEBI:16577", "name": "DHCA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_193457", "map_id": "CHEBI:15494", "name": "25(R) DHCA-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10513244", "map_id": "none", "name": "Isomerization of 25(R) THCA-CoA to 25(S) THCA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_192308", "map_id": "CHEBI:37642", "name": "25(R) THCA-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_192316", "map_id": "CHEBI:37643", "name": "25(S) THCA-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "reaction_10513405", "map_id": "none", "name": "DHCA is conjugated with Coenzyme A (SLC27A2 VLCS)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10513246", "map_id": "none", "name": "4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_192195", "map_id": "CHEBI:28477", "name": "4CHOL7a,12aDONE", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "reaction_10513310", "map_id": "none", "name": "25(S) THCA-CoA is dehydrogenated to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "reaction_10513407", "map_id": "none", "name": "Isomerization of 25(R) DHCA-CoA to 25(S) DHCA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_193429", "map_id": "CHEBI:15494", "name": "25(R) DHCA-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "reaction_10516904", "map_id": "none", "name": "Translocation of caspase-3 to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13231", "compartment_display": "nuclear envelope" }, { "id": "species_10516902", "map_id": "none", "name": "active caspase-3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10517886", "map_id": "none", "name": "Association of HMGB1/HMGB2 with chromatin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10517882", "map_id": "none", "name": "HMGB1/HMGB2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10517884", "map_id": "none", "name": "HMGB1/HMGB2- bound chromatin", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10551440", "map_id": "none", "name": "RAR:RXR binds SUMO-CRABP2:atRA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10551436", "map_id": "none", "name": "SUMO-K102-CRABP2:atRA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10551432", "map_id": "none", "name": "RAR:RXR", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10551438", "map_id": "none", "name": "SUMO-CRABP2:atRA:RAR:RXR", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10553123", "map_id": "none", "name": "FABP5 binds atRA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10551364", "map_id": "Q965W1", "name": "lbp-9", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10553121", "map_id": "none", "name": "FABP5:atRA", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10552339", "map_id": "none", "name": "RXRA:PPARD binds FABP5:atRA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10552335", "map_id": "none", "name": "FABP5:atRA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10514501", "map_id": "none", "name": "RXRA:PPARD", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10552337", "map_id": "none", "name": "RXRA:PPARD:atRA:FABP5", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10552705", "map_id": "none", "name": "AKR1C3 reduces atRAL to atROL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_975599", "map_id": "CHEBI:17336", "name": "atROL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10551747", "map_id": "none", "name": "RDH10,16,DHRS9,RDHE2 oxidise atROL to atRAL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10551744", "map_id": "none", "name": "RDH10,16,DHRS9,RDHE2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10553251", "map_id": "none", "name": "RDH13 reduces atRAL to atROL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane" }, { "id": "species_5623644", "map_id": "CHEBI:16474", "name": "NADPH", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "false" }, { "id": "species_5623650", "map_id": "CHEBI:18009", "name": "NADP+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "false" }, { "id": "species_10553248", "map_id": "Q9XVS9", "name": "dhs-22", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "WBGene00000985", "map_id": "WBGene00000985", "name": "dhs-22", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10551781", "map_id": "none", "name": "RDH5,RDH11 oxidise 11cROL to 11cRAL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_32737", "map_id": "CHEBI:16066", "name": "11cRAL", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10551778", "map_id": "none", "name": "Homologues of RDH5(24-318)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10553125", "map_id": "none", "name": "CRABP1 binds atRA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10551761", "map_id": "none", "name": "Homologues of SUMO-K-CRABP1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10551763", "map_id": "none", "name": "SUMO-CRABP1:atRA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10551862", "map_id": "none", "name": "RDH11,14,DHRS3,DRHS4 reduce atRAL to atROL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10551859", "map_id": "none", "name": "RDH11,14,DHRS3,DHRS4", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "P91013", "map_id": "P91013", "name": "dhs-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000965", "map_id": "WBGene00000965", "name": "dhs-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q1XFZ3", "map_id": "Q1XFZ3", "name": "dhs-17", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000980", "map_id": "WBGene00000980", "name": "dhs-17", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EGA6", "map_id": "G5EGA6", "name": "dhrs-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010063", "map_id": "WBGene00010063", "name": "dhrs-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10551768", "map_id": "none", "name": "ADH1A,1C,4 oxidise atROL to atRAL in vitro", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10551765", "map_id": "none", "name": "ADH1A,1C,4 dimers", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q17335", "map_id": "Q17335", "name": "ADH4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019240", "map_id": "WBGene00019240", "name": "ADH4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10557581", "map_id": "none", "name": "ALDH8A1 oxidises 9cRAL to 9cRA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5362565", "map_id": "CHEBI:78273", "name": "9cRAL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_5362520", "map_id": "CHEBI:50648", "name": "9cRA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10557578", "map_id": "Q18822", "name": "alh-10", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00000116", "map_id": "WBGene00000116", "name": "alh-10", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10554022", "map_id": "none", "name": "FABP5:atRA translocates from cytosol to nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10554024", "map_id": "none", "name": "FABP5 dissociates from RXRA:PPARD:atRA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10552333", "map_id": "Q965W1", "name": "lbp-9", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10514505", "map_id": "none", "name": "CPT1A,B transfers PALM to CAR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_549207", "map_id": "CHEBI:17126", "name": "CAR", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "false" }, { "id": "species_201034", "map_id": "CHEBI:17490", "name": "L-PCARN", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "false" }, { "id": "species_10514471", "map_id": "none", "name": "CPT1A,B", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "true" }, { "id": "Q9N3N3", "map_id": "Q9N3N3", "name": "cpt-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021703", "map_id": "WBGene00021703", "name": "cpt-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O16992", "map_id": "O16992", "name": "CPT1B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021002", "map_id": "WBGene00021002", "name": "CPT1B", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9U2F2", "map_id": "Q9U2F2", "name": "cpt-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012907", "map_id": "WBGene00012907", "name": "cpt-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O44619", "map_id": "O44619", "name": "cpt-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019644", "map_id": "WBGene00019644", "name": "cpt-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q23066", "map_id": "Q23066", "name": "cpt-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020911", "map_id": "WBGene00020911", "name": "cpt-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EG54", "map_id": "G5EG54", "name": "cpt-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008629", "map_id": "WBGene00008629", "name": "cpt-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10554028", "map_id": "none", "name": "SUMO-CRABP2 dissociates from atRA:RAR:RXR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10551434", "map_id": "O01812", "name": "lbp-6", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10554026", "map_id": "none", "name": "atRA:RAR:RXR", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10551391", "map_id": "none", "name": "SUMO-CRABP2 binds atRA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10551387", "map_id": "O01812", "name": "lbp-6", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10551389", "map_id": "none", "name": "SUMO-K102-CRABP2:atRA", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10554030", "map_id": "none", "name": "SUMO-CRABP2:atRA translocates from cytosol to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10570912", "map_id": "none", "name": "p-TEFb phosphorylates serine 2 in RNA polymerase II CTD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10570907", "map_id": "none", "name": "MYB gene:hypophosphorylated RNA polymerase II:TFIIF:ESR1:ESTG:P-TEFb", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10570909", "map_id": "none", "name": "MYB gene:hyperphosphorylated RNA polymerase II:TFIIF:ESR1:ESTG:P-TEFb", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10570805", "map_id": "none", "name": "TBP and TFIIA bind TATA box on ESR1:estrogen bound TFF1 gene promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10506254", "map_id": "P32085", "name": "tbp-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10570801", "map_id": "none", "name": "ESR1:estrogen:TFF1 gene:FOXA1:GATA3:DDX5", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "CHEBI:142773", "map_id": "CHEBI:142773", "name": "CHEBI:142773", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:27974", "map_id": "CHEBI:27974", "name": "CHEBI:27974", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EGN3", "map_id": "G5EGN3", "name": "elt-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001253", "map_id": "WBGene00001253", "name": "elt-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P28515", "map_id": "P28515", "name": "elt-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001249", "map_id": "WBGene00001249", "name": "elt-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XUW7", "map_id": "Q9XUW7", "name": "end-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001311", "map_id": "WBGene00001311", "name": "end-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EF25", "map_id": "G5EF25", "name": "med-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003181", "map_id": "WBGene00003181", "name": "med-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EF71", "map_id": "G5EF71", "name": "med-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003180", "map_id": "WBGene00003180", "name": "med-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "U4PMB4", "map_id": "U4PMB4", "name": "egl-18", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001186", "map_id": "WBGene00001186", "name": "egl-18", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q21187", "map_id": "Q21187", "name": "fkh-9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001441", "map_id": "WBGene00001441", "name": "fkh-9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q17381", "map_id": "Q17381", "name": "pha-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004013", "map_id": "WBGene00004013", "name": "pha-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10570803", "map_id": "none", "name": "TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene:FOXA1:GATA3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10570772", "map_id": "none", "name": "FOXA1 and GATA3 bind to CCND1 promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10570727", "map_id": "none", "name": "CCND1 gene:H3K4me2 nucleosome:YY1:HDAC1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "P45972", "map_id": "P45972", "name": "ztf-17", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011639", "map_id": "WBGene00011639", "name": "ztf-17", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10570739", "map_id": "none", "name": "Homologues of FOXA1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10570768", "map_id": "none", "name": "Homologues of GATA3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10570725", "map_id": "P45972", "name": "ztf-17", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10570770", "map_id": "none", "name": "CCND1 gene:H3K4me2 nucleosome:FOXA1:GATA3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10571524", "map_id": "none", "name": "Histone acetyltransferases are recruited to the TFF1 gene", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10571512", "map_id": "none", "name": "histone acetyltransferases", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9TYU5", "map_id": "Q9TYU5", "name": "mys-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007029", "map_id": "WBGene00007029", "name": "mys-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10571520", "map_id": "none", "name": "ESR1:estrogen:TFF1 gene:FOXA1:GATA3:DDX5:TBP:TFIIA:CARM1,PRMT1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9U2X0", "map_id": "Q9U2X0", "name": "prmt-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10571522", "map_id": "none", "name": "ESR1:estrogen:TFF1gene:FOXA1:GATA3:DDX5:TBP:TFIIA:CARM1,PRMT1:HATs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10571526", "map_id": "none", "name": "PRMT1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10571518", "map_id": "none", "name": "ESR1:estrogen:TFF1 gene:DDX5:TBP:TFIIA:PRMT1:FOXA1:GATA3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10568500", "map_id": "none", "name": "ESTG binds ESR1:chaperone complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10568488", "map_id": "none", "name": "ESR1:chaperone complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q09637", "map_id": "Q09637", "name": "cyn-9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000885", "map_id": "WBGene00000885", "name": "cyn-9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10568490", "map_id": "none", "name": "ESTG:ESR1:chaperone complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10573334", "map_id": "none", "name": "ESTG binds ESR2:chaperone complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10568494", "map_id": "none", "name": "ESR2:chaperone complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10568496", "map_id": "none", "name": "ESTG:ESR2:chaperone complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10515169", "map_id": "none", "name": "eNOS synthesizes NO", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_202124", "map_id": "CHEBI:16480", "name": "NO", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10515166", "map_id": "none", "name": "p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_5693375", "map_id": "CHEBI:25682", "name": "ADMA", "type": "inhibitor", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10572255", "map_id": "none", "name": "AKT phosphorylates FOXO3 downstream of ESR1 and EGFR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10572334", "map_id": "none", "name": "p-S10 CDKN1B translocates to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10572330", "map_id": "G5EEJ2", "name": "phospho-cki-2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10572332", "map_id": "G5EEJ2", "name": "phospho-cki-2", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10514056", "map_id": "none", "name": "p-Y185,Y187 MAPK1 dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10511186", "map_id": "Q23089", "name": "xpo-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00002078", "map_id": "WBGene00002078", "name": "xpo-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10572317", "map_id": "none", "name": "PTK2 is recruited to methylated ESR1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10572313", "map_id": "Q95YD4", "name": "phospho-kin-32", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10572310", "map_id": "none", "name": "Me260-ESR1:STRN:ESTG:MyrG-pY419 SRC:PI3K alpha", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10572315", "map_id": "none", "name": "Me260-ESR1:STRN:ESTG: MyrG-pY419 SRC:PI3Kalpha:pY-PTK2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10572284", "map_id": "none", "name": "SPHK1 phosphorylates sphingosine in response to E2 stimulation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_1606609", "map_id": "CHEBI:16393", "name": "SPG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_5218688", "map_id": "CHEBI:37550", "name": "S1P", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10572339", "map_id": "none", "name": "PRKCZ recruits RAS in response to estrogen stimulation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10572324", "map_id": "none", "name": "PDPK1:PIP3:pS, p-T410 PRKCZ", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q19266", "map_id": "Q19266", "name": "phospho-pkc-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10572337", "map_id": "none", "name": "PDPK1:PIP3:pS, p-T410 PRKCZ:p21 RAS:GDP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10572327", "map_id": "none", "name": "PRKCZ autophosphorylates downstream of estrogen stimulation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10572319", "map_id": "none", "name": "PDPK1:PIP3:p-T410-PRKCZ", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10572343", "map_id": "none", "name": "ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10542080", "map_id": "none", "name": "p-T185,Y187 MAPK1 dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10572341", "map_id": "none", "name": "PDPK1:PIP3:pS, p-T410 PRKCZ:p21 RAS:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10572346", "map_id": "none", "name": "PRKCZ stimulates RAS nucleotide exchange in response to estrogen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10571584", "map_id": "none", "name": "Co-repressor complex dissociates from the transcription unit of the UGT1A3 gene ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10571574", "map_id": "none", "name": "UGT1A3 gene:NR1H2,3:RXR:NR1H2,3 ligand:NCOR", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "CHEBI:34310", "map_id": "CHEBI:34310", "name": "CHEBI:34310", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:67237", "map_id": "CHEBI:67237", "name": "CHEBI:67237", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:76591", "map_id": "CHEBI:76591", "name": "CHEBI:76591", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:41633", "map_id": "CHEBI:41633", "name": "CHEBI:41633", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34333", "map_id": "P34333", "name": "gei-8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001565", "map_id": "WBGene00001565", "name": "gei-8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10571582", "map_id": "none", "name": "UGT1A3 gene:NR1H2,3:RXR:NR1H2,3 ligand", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10517933", "map_id": "P34333", "name": "gei-8", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10571576", "map_id": "none", "name": "Oxysterol binds to the UGT1A3 gene:NR1H2,3:RXR:NCOR complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_9024383", "map_id": "none", "name": "NR1H3, NR1H2 ligands", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10571572", "map_id": "none", "name": "UGT1A3 gene:NR1H2,3:RXR:NCOR", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10537280", "map_id": "none", "name": "PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_1524146", "map_id": "CHEBI:16749", "name": "PI", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "species_10537269", "map_id": "Q93641", "name": "sac-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "WBGene00009264", "map_id": "WBGene00009264", "name": "sac-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10537217", "map_id": "none", "name": "PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_1806159", "map_id": "CHEBI:17283", "name": "PI3P", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "species_10537193", "map_id": "none", "name": "PIK3C2A/3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "G5EDY0", "map_id": "G5EDY0", "name": "piki-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009552", "map_id": "WBGene00009552", "name": "piki-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10537185", "map_id": "none", "name": "PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A/G at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_1806230", "map_id": "CHEBI:16152", "name": "PI(3,4)P2", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "species_10537182", "map_id": "none", "name": "PIK3C2A/G", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10537298", "map_id": "none", "name": "PI4KB binds to ARF1/3:GTP at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10537169", "map_id": "none", "name": "ARF1/3:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "G5EFK4", "map_id": "G5EFK4", "name": "arf-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000183", "map_id": "WBGene00000183", "name": "arf-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q10943", "map_id": "Q10943", "name": "arf-1.2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000182", "map_id": "WBGene00000182", "name": "arf-1.2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10537296", "map_id": "Q20077", "name": "pifk-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00018076", "map_id": "WBGene00018076", "name": "pifk-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10537171", "map_id": "none", "name": "ARF1/3:GTP:PI4KB", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "Q20077", "map_id": "Q20077", "name": "pifk-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10537141", "map_id": "none", "name": "PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_1806165", "map_id": "CHEBI:18348", "name": "PI(4,5)P2", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "species_10537138", "map_id": "O17590", "name": "ocrl-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00007620", "map_id": "WBGene00007620", "name": "ocrl-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10537174", "map_id": "none", "name": "PI is phosphorylated to PI4P by PI4KB at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "reaction_10537272", "map_id": "none", "name": "PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "reaction_10537322", "map_id": "none", "name": "PI is phosphorylated to PI4P by PI4KA/2A/2B at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10537319", "map_id": "none", "name": "PI4KA/2A/2B", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "O45318", "map_id": "O45318", "name": "PI4K2B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022501", "map_id": "WBGene00022501", "name": "PI4K2B", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q23083", "map_id": "Q23083", "name": "PI4K2B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XW63", "map_id": "Q9XW63", "name": "PI4KA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013557", "map_id": "WBGene00013557", "name": "PI4KA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10502079", "map_id": "none", "name": "Orc1 associates with Orc4:Orc5:Orc3:Orc2:origin complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10502075", "map_id": "Q9XX17", "name": "orc-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10502070", "map_id": "none", "name": "Orc4:Orc5:Orc3:Orc2:origin", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10502077", "map_id": "none", "name": "Orc1:Orc4:Orc5:Orc3:Orc2:origin", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10548052", "map_id": "none", "name": "WNT signaling stimulates CSNK1-dependent phosphorylation of DVL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10515075", "map_id": "none", "name": "p-DVL", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10515002", "map_id": "none", "name": "pp-DVL", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10548049", "map_id": "Q20471", "name": "kin-20", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00002203", "map_id": "WBGene00002203", "name": "kin-20", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10548055", "map_id": "none", "name": "DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10548042", "map_id": "none", "name": "ppDVL:PIP5K1B", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "O01759", "map_id": "O01759", "name": "ppk-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10515100", "map_id": "none", "name": "CSNK2-mediated phosphorylation of DVL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10515052", "map_id": "none", "name": "DVL", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10548044", "map_id": "none", "name": "Phosphorylated DVL recruits PIP5K1B to the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10537053", "map_id": "O01759", "name": "ppk-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10573013", "map_id": "none", "name": "ANKLE2 binds PP2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10546138", "map_id": "H2KZB2", "name": "lem-4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "WBGene00021945", "map_id": "WBGene00021945", "name": "lem-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10529273", "map_id": "none", "name": "PP2A (Aalpha:B55alpha:Calpha)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10573011", "map_id": "none", "name": "ANKLE2:PP2A", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "H2KZB2", "map_id": "H2KZB2", "name": "lem-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10546149", "map_id": "none", "name": "ANKLE2 binds VRK1,(VRK2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10546143", "map_id": "Q19848", "name": "vrk-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00017895", "map_id": "WBGene00017895", "name": "vrk-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10546147", "map_id": "none", "name": "ANKLE2:VRK1/VRK2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q19848", "map_id": "Q19848", "name": "vrk-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10572275", "map_id": "none", "name": "RCC1 stimulates GDP to GTP exchange on RAN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_1598585", "compartment_display": "chromosome" }, { "id": "species_10558002", "map_id": "none", "name": "RAN:GDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "O17915", "map_id": "O17915", "name": "ran-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004302", "map_id": "WBGene00004302", "name": "ran-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10572267", "map_id": "none", "name": "RAN:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10572272", "map_id": "Q18211", "name": "ran-3", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_1598585", "compartment_display": "chromosome", "complex": "false" }, { "id": "WBGene00004304", "map_id": "WBGene00004304", "name": "ran-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10572213", "map_id": "none", "name": "POM121 binds the Nup107-Nup160 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10507233", "map_id": "Q17602", "name": "npp-14", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_13231", "compartment_display": "nuclear envelope", "complex": "false" }, { "id": "WBGene00003800", "map_id": "WBGene00003800", "name": "npp-14", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10572209", "map_id": "none", "name": "Nup107-160 complex:AHCTF1:Chromatin", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P34343", "map_id": "P34343", "name": "npp-15", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003801", "map_id": "WBGene00003801", "name": "npp-15", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q17872", "map_id": "Q17872", "name": "npp-23", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007493", "map_id": "WBGene00007493", "name": "npp-23", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8T8M4", "map_id": "Q8T8M4", "name": "npp-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003792", "map_id": "WBGene00003792", "name": "npp-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9N4A7", "map_id": "Q9N4A7", "name": "npp-20", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003806", "map_id": "WBGene00003806", "name": "npp-20", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q22078", "map_id": "Q22078", "name": "npp-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003788", "map_id": "WBGene00003788", "name": "npp-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O45933", "map_id": "O45933", "name": "npp-18", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003804", "map_id": "WBGene00003804", "name": "npp-18", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q19131", "map_id": "Q19131", "name": "npp-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003791", "map_id": "WBGene00003791", "name": "npp-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EEH9", "map_id": "G5EEH9", "name": "npp-10", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003796", "map_id": "WBGene00003796", "name": "npp-10", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10572211", "map_id": "none", "name": "POM121:Nup107-160 complex:AHCTF1:Chromatin", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_13231", "compartment_display": "nuclear envelope", "complex": "true" }, { "id": "Q17602", "map_id": "Q17602", "name": "npp-14", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10572279", "map_id": "none", "name": "RAN:GTP recruits nuclear envelope (NE) membranes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9624879", "map_id": "none", "name": "Nuclear envelope vesicle", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_13231", "compartment_display": "nuclear envelope", "complex": "false" }, { "id": "species_10572277", "map_id": "none", "name": "RAN:GTP:Nuclear envelope vesicles", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_13231", "compartment_display": "nuclear envelope", "complex": "true" }, { "id": "reaction_10572282", "map_id": "none", "name": "RAN stimulates fusion of nuclear envelope (NE) membranes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9624890", "map_id": "none", "name": "Fused nuclear envelope vesicles", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_13231", "compartment_display": "nuclear envelope", "complex": "false" }, { "id": "reaction_10573042", "map_id": "none", "name": "VPS4 binds ESCRT-III assemblies at nuclear envelope (NE) fenestrations", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10573038", "map_id": "Q9BL83", "name": "vps-4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00021334", "map_id": "WBGene00021334", "name": "vps-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10573033", "map_id": "none", "name": "LEM2D:ESCRT-III:IST1:CC2D1B:SPAST", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_13231", "compartment_display": "nuclear envelope", "complex": "true" }, { "id": "Q9U2M8", "map_id": "Q9U2M8", "name": "CC2D1B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012578", "map_id": "WBGene00012578", "name": "CC2D1B", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XTB5", "map_id": "Q9XTB5", "name": "lem-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002275", "map_id": "WBGene00002275", "name": "lem-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8MNV0", "map_id": "Q8MNV0", "name": "spas-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016045", "map_id": "WBGene00016045", "name": "spas-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10573040", "map_id": "none", "name": "LEM2D:ESCRT-III:IST1:CC2D1B:SPAST:VPS4A", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_13231", "compartment_display": "nuclear envelope", "complex": "true" }, { "id": "Q9BL83", "map_id": "Q9BL83", "name": "vps-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10573044", "map_id": "none", "name": "CHMP7 binds CC2D1B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13231", "compartment_display": "nuclear envelope" }, { "id": "species_10573029", "map_id": "none", "name": "LEMD2:ESCRT-III:IST1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_13231", "compartment_display": "nuclear envelope", "complex": "true" }, { "id": "species_10573025", "map_id": "Q9U2M8", "name": "CC2D1B", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_13231", "compartment_display": "nuclear envelope", "complex": "false" }, { "id": "species_10573031", "map_id": "none", "name": "LEM2D:ESCRT-III:IST1:CC2D1B", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_13231", "compartment_display": "nuclear envelope", "complex": "true" }, { "id": "reaction_10573046", "map_id": "none", "name": "SPAST (spastin) binds the IST1 subunit of ESCRT-III at the sites of microtubule attachment to chromatin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10573020", "map_id": "Q8MNV0", "name": "spas-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10544436", "map_id": "none", "name": "Autocleavage of ESPL1 (Separase)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10544425", "map_id": "G5ED39", "name": "sep-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00004775", "map_id": "WBGene00004775", "name": "sep-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10544433", "map_id": "none", "name": "ESPL1 Autocleaved", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "G5ED39", "map_id": "G5ED39", "name": "sep-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10509875", "map_id": "none", "name": "PLK1 phosphorylates NUDC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10509869", "map_id": "G5EE74", "name": "nud-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00003829", "map_id": "WBGene00003829", "name": "nud-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10509873", "map_id": "G5EE74", "name": "phospho-nud-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10509861", "map_id": "Q9N2L7", "name": "phospho-plk-2", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10572564", "map_id": "none", "name": "EML4 trimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10572560", "map_id": "O45487", "name": "elp-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00001248", "map_id": "WBGene00001248", "name": "elp-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10572562", "map_id": "none", "name": "EML4 homotrimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "O45487", "map_id": "O45487", "name": "elp-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10544760", "map_id": "none", "name": "Dephosphorylation of CK2-modified condensin I", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10544748", "map_id": "none", "name": "CK2 Phosphorylated Condensin I", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "G5EFJ4", "map_id": "G5EFJ4", "name": "phospho-capg-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009254", "map_id": "WBGene00009254", "name": "phospho-capg-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9U2M1", "map_id": "Q9U2M1", "name": "phospho-dpy-28", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001087", "map_id": "WBGene00001087", "name": "phospho-dpy-28", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10544758", "map_id": "none", "name": "Condensin I", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_2529006", "map_id": "none", "name": "Unknown Phosphatase", "type": "catalyst", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10544762", "map_id": "none", "name": "CK2 phosphorylates condensin I subunits", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10544517", "map_id": "none", "name": "CDK1 phosphorylates CDCA5 (Sororin) at chromosomal arms", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_1598585", "compartment_display": "chromosome" }, { "id": "species_10544514", "map_id": "none", "name": "Sister Chromosomal Arms:Ac-Cohesin:PDS5:CDCA5:WAPAL", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_1598585", "compartment_display": "chromosome", "complex": "true" }, { "id": "species_10544390", "map_id": "none", "name": "Sister Chromosomal Arms:Ac-Cohesin:PDS5:p-CDCA5:WAPAL", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_1598585", "compartment_display": "chromosome", "complex": "true" }, { "id": "species_10511266", "map_id": "none", "name": "CCNB1,CCNB2:p-T161-CDK1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10544410", "map_id": "none", "name": "Phosphorylation of cohesin by PLK1 at chromosomal arms", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_1598585", "compartment_display": "chromosome" }, { "id": "species_10544407", "map_id": "none", "name": "Sister Chromosomal Arms:p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_1598585", "compartment_display": "chromosome", "complex": "true" }, { "id": "species_10511228", "map_id": "Q9N2L7", "name": "plk-2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10544537", "map_id": "none", "name": "Cohesin binding to decondensed chromatin is facilitated by NIPBL:MAU2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_1598585", "compartment_display": "chromosome" }, { "id": "species_2537690", "map_id": "none", "name": "Chromatin", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_1598585", "compartment_display": "chromosome", "complex": "false" }, { "id": "species_10544484", "map_id": "none", "name": "Cohesin:PDS5:WAPAL", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10544529", "map_id": "none", "name": "NIPBL:MAU2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "O17581", "map_id": "O17581", "name": "mau-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003136", "map_id": "WBGene00003136", "name": "mau-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q95XZ5", "map_id": "Q95XZ5", "name": "pqn-85", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004166", "map_id": "WBGene00004166", "name": "pqn-85", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10544535", "map_id": "none", "name": "Cohesin:PDS5:WAPAL:NIPBL:MAU2:Chromatin", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10544508", "map_id": "none", "name": "Cohesin binds PDS5 and WAPAL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10544478", "map_id": "G5EC05", "name": "evl-14", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10544482", "map_id": "H2L0H5", "name": "wapl-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10509854", "map_id": "none", "name": "Regulation of KIF23 (MKLP1) by phosphorylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10509841", "map_id": "Q8MQ03", "name": "zen-4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00006974", "map_id": "WBGene00006974", "name": "zen-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10509845", "map_id": "Q8MQ03", "name": "phospho-zen-4", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10569693", "map_id": "none", "name": "FAM20C phosphorylates FAM20C substrates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_8931885", "map_id": "CHEBI:30616", "name": "ATP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10569440", "map_id": "none", "name": "FAM20C:FAM20C substrates", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "Q9XTW2", "map_id": "Q9XTW2", "name": "famk-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010356", "map_id": "WBGene00010356", "name": "famk-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q22235", "map_id": "Q22235", "name": "phospho-enpl-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "H2L2L3", "map_id": "H2L2L3", "name": "anoh-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013326", "map_id": "WBGene00013326", "name": "anoh-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q17770", "map_id": "Q17770", "name": "phospho-pdi-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003963", "map_id": "WBGene00003963", "name": "phospho-pdi-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8WQF8", "map_id": "Q8WQF8", "name": "phospho-p-APOL1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017220", "map_id": "WBGene00017220", "name": "phospho-p-APOL1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8WQF7", "map_id": "Q8WQF7", "name": "phospho-p-APOL1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9GZD8", "map_id": "Q9GZD8", "name": "phospho-p-LGALS1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00235368", "map_id": "WBGene00235368", "name": "phospho-p-LGALS1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O01330", "map_id": "O01330", "name": "phospho-p-LGALS1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9GZD9", "map_id": "Q9GZD9", "name": "phospho-p-LGALS1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O01331", "map_id": "O01331", "name": "phospho-p-LGALS1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9GZE0", "map_id": "Q9GZE0", "name": "phospho-p-LGALS1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P36573", "map_id": "P36573", "name": "phospho-lec-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002264", "map_id": "WBGene00002264", "name": "phospho-lec-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9N384", "map_id": "Q9N384", "name": "phospho-lec-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002269", "map_id": "WBGene00002269", "name": "phospho-lec-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "C4RVF6", "map_id": "C4RVF6", "name": "phospho-p-LGALS1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q09581", "map_id": "Q09581", "name": "phospho-lec-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002266", "map_id": "WBGene00002266", "name": "phospho-lec-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "U4PM93", "map_id": "U4PM93", "name": "phospho-p-LGALS1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q18625", "map_id": "Q18625", "name": "phospho-lec-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002267", "map_id": "WBGene00002267", "name": "phospho-lec-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "K8ERT0", "map_id": "K8ERT0", "name": "phospho-p-LGALS1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q20684", "map_id": "Q20684", "name": "phospho-lec-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002265", "map_id": "WBGene00002265", "name": "phospho-lec-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O01329", "map_id": "O01329", "name": "phospho-p-LGALS1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8MQ51", "map_id": "Q8MQ51", "name": "phospho-nucb-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009674", "map_id": "WBGene00009674", "name": "phospho-nucb-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q11067", "map_id": "Q11067", "name": "phospho-pdi-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00015168", "map_id": "WBGene00015168", "name": "phospho-pdi-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q11186", "map_id": "Q11186", "name": "atgl-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00015484", "map_id": "WBGene00015484", "name": "atgl-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EC87", "map_id": "G5EC87", "name": "phospho-p-PRKCSH", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00014249", "map_id": "WBGene00014249", "name": "phospho-p-PRKCSH", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EBH7", "map_id": "G5EBH7", "name": "phospho-calu-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019760", "map_id": "WBGene00019760", "name": "phospho-calu-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34714", "map_id": "P34714", "name": "phospho-ost-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003893", "map_id": "WBGene00003893", "name": "phospho-ost-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q09EE8", "map_id": "Q09EE8", "name": "phospho-p-STC2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00044988", "map_id": "WBGene00044988", "name": "phospho-p-STC2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q5ZR75", "map_id": "Q5ZR75", "name": "phospho-p-FGG", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020516", "map_id": "WBGene00020516", "name": "phospho-p-FGG", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9BL47", "map_id": "Q9BL47", "name": "phospho-p-TMEM132A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022175", "map_id": "WBGene00022175", "name": "phospho-p-TMEM132A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q18096", "map_id": "Q18096", "name": "phospho-p-TNC", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007687", "map_id": "WBGene00007687", "name": "phospho-p-TNC", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10569686", "map_id": "none", "name": "FAM20C:Phosphorylated FAM20C substrates", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "species_8931884", "map_id": "CHEBI:456216", "name": "ADP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10569691", "map_id": "none", "name": "FAM20C:FAM20A", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "reaction_10554323", "map_id": "none", "name": "Rag dimer formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10510565", "map_id": "none", "name": "RRAGA, RRAGB:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10510578", "map_id": "none", "name": "RRAGC,RRAGD:GDP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10510580", "map_id": "none", "name": "RagA,B:GTP:RagC,D:GDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10554325", "map_id": "none", "name": "Ragulator:Rag dimers:SLC38A9 bind mTORC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane" }, { "id": "species_10510526", "map_id": "none", "name": "mTORC1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10510584", "map_id": "none", "name": "Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "species_10510586", "map_id": "none", "name": "mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "reaction_10554902", "map_id": "none", "name": "mTORC1 phosphorylates AKT1S1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane" }, { "id": "species_10510629", "map_id": "none", "name": "mTORC1:p-T246-AKT1S1:YWHAB", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "species_10554899", "map_id": "none", "name": "mTORC1:RHEB:GTP:p-S183,T246-AKT1S1:YWHAB", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "reaction_10569771", "map_id": "none", "name": "SLC38A9 transports L-Arg from lysosomal lumen to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_428011", "map_id": "CHEBI:32682", "name": "L-Arg", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "reaction_10554893", "map_id": "none", "name": "Phosphorylated AKT1S1:mTORC1 binds YWHAB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane" }, { "id": "species_10510627", "map_id": "none", "name": "mTORC1:RHEB:GTP:p-T246-AKT1S1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "reaction_10510643", "map_id": "none", "name": "Phosphorylation of Ribosomal protein S6 by activated S6K1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10505506", "map_id": "Q9NEN6", "name": "rps-6", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10510640", "map_id": "Q9NEN6", "name": "phospho-rps-6", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10510612", "map_id": "none", "name": "Homologues of p-S371,T389-RPS6KB1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9NAH6", "map_id": "Q9NAH6", "name": "phospho-rsks-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q21694", "map_id": "Q21694", "name": "RPS6KB1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00044281", "map_id": "WBGene00044281", "name": "RPS6KB1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10510660", "map_id": "none", "name": "Phosphorylation and activation of eIF4G by activated S6K1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10505665", "map_id": "A0A486WX07", "name": "ifg-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10510658", "map_id": "A0A486WX07", "name": "phospho-ifg-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10510631", "map_id": "none", "name": "mTORC1 phosphorylation of RPS6KB1 (S6K)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane" }, { "id": "species_10510602", "map_id": "none", "name": "Homologues of RPS6KB1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10510665", "map_id": "none", "name": "Phosphorylation and activation of eIF4B by activated S6K1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10505672", "map_id": "H2L0A8", "name": "EIF4B", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10510663", "map_id": "H2L0A8", "name": "phospho-p-S422-EIF4B", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10510653", "map_id": "none", "name": "Phosphorylation and inactivation of eEF2K by activated S6K1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10510648", "map_id": "O01991", "name": "efk-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00001160", "map_id": "WBGene00001160", "name": "phospho-efk-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10510651", "map_id": "O01991", "name": "phospho-efk-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10519956", "map_id": "none", "name": "Phosphorylated AMPK binds AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10514570", "map_id": "none", "name": "p-AMPK heterotrimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10525223", "map_id": "none", "name": "AMPK phosphorylates Raptor in the mTORC1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10519961", "map_id": "none", "name": "AMPK is dephosphorylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10514555", "map_id": "none", "name": "AMPK heterotrimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10519958", "map_id": "Q19775", "name": "ppm-1.A", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10510509", "map_id": "none", "name": "GTP loading by Rheb", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane" }, { "id": "species_10510505", "map_id": "none", "name": "RHEB:GDP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "species_10510507", "map_id": "none", "name": "RHEB:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "reaction_10510590", "map_id": "none", "name": "Formation of active mTORC1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10519535", "map_id": "none", "name": "Activated Akt1 phosphorylates AKT1S1 (PRAS40)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane" }, { "id": "species_10519532", "map_id": "none", "name": "mTORC1:RHEB:GTP:AKT1S1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "species_10515152", "map_id": "none", "name": "Homologues of p-T308,S473-AKT1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10509895", "map_id": "none", "name": "Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10509891", "map_id": "Q27389", "name": "phospho-rpl-16", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10509893", "map_id": "none", "name": "phospho-L13a associated wth the 3' UTR GAIT element of ceruloplasmin mRNA within the translation initiation complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10509899", "map_id": "none", "name": "Dissociation of L13a from the 60s ribosomal subunit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10505970", "map_id": "none", "name": "60S ribosomal complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10509897", "map_id": "none", "name": "60s ribosomal complex lacking L13a subunit", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10505768", "map_id": "Q27389", "name": "rpl-16", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10550786", "map_id": "none", "name": "ROCK1,ROCK2 are activated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10550784", "map_id": "none", "name": "RHOA:GTP:Mg2+:Activated ROCK1,ROCK2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10550628", "map_id": "none", "name": "FYN phosphorylates PAK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10550625", "map_id": "none", "name": "VEGFA:p-6Y-VEGFR2:NCK:p-S21,Y420-FYN:p-2Y-PAK2:CDC42:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10550576", "map_id": "none", "name": "VEGFA:p-6Y-VEGFR2:NCK:p-S21,Y420-FYN:p-3Y-PAK2:CDC42:GTP", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10550693", "map_id": "none", "name": "p-MAPK2/3 phosphorylates HSP27", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10550685", "map_id": "none", "name": "HSP27 oligomer:F-actin", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q17849", "map_id": "Q17849", "name": "phospho-hsp-25", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002023", "map_id": "WBGene00002023", "name": "phospho-hsp-25", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10550690", "map_id": "Q17849", "name": "phospho-hsp-25", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10550665", "map_id": "none", "name": "CDC42:GTP binds PAK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10550663", "map_id": "none", "name": "VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN:PAK2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10550636", "map_id": "none", "name": "VEGFA:p-6Y-VEGFR2:NCK:p-S21,Y420-FYN:PAK2:CDC42:GTP", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10550667", "map_id": "none", "name": "PAK2 binds NCK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10550562", "map_id": "none", "name": "VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10550639", "map_id": "none", "name": "PAK2 autophorylates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10550610", "map_id": "none", "name": "PKC autophosphorylates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10550592", "map_id": "none", "name": "p-PKCA,p-PKCB,p-PKCZ,p-PKCD", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10550607", "map_id": "none", "name": "p-PKC", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10550659", "map_id": "none", "name": "PKC phosphorylates sphingosine kinase 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10550656", "map_id": "Q18425", "name": "phospho-sphk-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10550630", "map_id": "none", "name": "DAG:active PKC:Ca+2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10550653", "map_id": "none", "name": "PDK1 phosphorylates PKC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10550650", "map_id": "none", "name": "PKCA,PKCB,PKCD,PKCZ", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10550579", "map_id": "none", "name": "p38 MAPK activation by VEGFR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10526151", "map_id": "none", "name": "MAP kinase p38 (Mg2+ cofactor)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10548788", "map_id": "none", "name": "RHOA:GTP:Mg2+ binds ROCK1,ROCK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10550644", "map_id": "none", "name": "VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10550641", "map_id": "none", "name": "VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10569044", "map_id": "none", "name": "p-VAV family:PIP3 binds RAC1:GDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10550646", "map_id": "none", "name": "p-VAV family:PIP3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10550669", "map_id": "none", "name": "p-VAV family:PIP3:RAC1:GDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10551522", "map_id": "none", "name": "PAK1-3 dimer disassociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10551518", "map_id": "none", "name": "2 x p-VAV family:PIP3:RAC1:GTP:PAK 1-3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10551520", "map_id": "none", "name": "p-VAV family:PIP3:RAC1:GTP:PAK 1-3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10551525", "map_id": "none", "name": "PAK1-3 autophosphorylates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10550671", "map_id": "none", "name": "p-VAV family:PIP3:RAC1:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10520686", "map_id": "none", "name": "PAK1,2,3 dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10551558", "map_id": "none", "name": "PAK1-3 phosphorylates VE-cadherin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10551551", "map_id": "none", "name": "VE-cadherin-Catenin complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "P90947", "map_id": "P90947", "name": "hmp-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001978", "map_id": "WBGene00001978", "name": "hmp-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10551555", "map_id": "none", "name": "p-S665-VE-cadherin-Catenin complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10551560", "map_id": "none", "name": "RAC1 binds PAK1-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10515164", "map_id": "none", "name": "AKT1 phosphorylates eNOS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10515154", "map_id": "none", "name": "eNOS:CaM:HSP90:p-AKT1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10515162", "map_id": "none", "name": "p-S1177-eNOS:CaM:HSP90:p-AKT1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10535150", "map_id": "none", "name": "The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10550679", "map_id": "none", "name": "p-Y420-FYN is phosphorylated on S21", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10550614", "map_id": "none", "name": "VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-Y420-FYN", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10550676", "map_id": "none", "name": "Protein kinase A catalytic subunit", "type": "catalyst", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10550617", "map_id": "none", "name": "FYN autophosphorylates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10550612", "map_id": "none", "name": "VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:FYN", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10565172", "map_id": "none", "name": "MET phosphorylates GAB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10565169", "map_id": "none", "name": "HGF:p-4Y-MET dimer:GRB2-1:GAB1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10565174", "map_id": "none", "name": "Phosphorylated GAB1 recruits PI3K to MET", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10543881", "map_id": "none", "name": "HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:PI3K", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10565177", "map_id": "none", "name": "MET bound PI3K generates PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10532954", "map_id": "none", "name": "RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10532951", "map_id": "none", "name": "NRGs/EGFLs:p-ERBB4:p-ERBB2:GRB2:SOS1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10532961", "map_id": "none", "name": "PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10532958", "map_id": "none", "name": "NRGs/EGFLs:p-ERBB4cyt1:p-ERBB2:PI3K", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10532945", "map_id": "none", "name": "PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10532942", "map_id": "none", "name": "EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PI3K", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10532947", "map_id": "none", "name": "Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR.", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10532938", "map_id": "none", "name": "EGF:p-EGFR:p-ERBB2:GRB2:GAB1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10532507", "map_id": "none", "name": "PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10532504", "map_id": "none", "name": "NRG1/2:p-ERBB3:p-ERBB2:PI3K", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10572739", "map_id": "none", "name": "ERBB2 binds TKIs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9652360", "map_id": "none", "name": "lapatinib, neratinib, afatinib, AZ5104, tesevatinib, canertinib, sapitinib, CP-724714, AEE78", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10538183", "map_id": "none", "name": "ERBB2:ERBIN:HSP90:CDC37", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "O02108", "map_id": "O02108", "name": "cdc-37", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021097", "map_id": "WBGene00021097", "name": "cdc-37", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10572737", "map_id": "none", "name": "ERBB2:TKIs:ERBIN:HSP90:CDC37", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10538193", "map_id": "none", "name": "CUL5 mediates ubiquitination of ERBB2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10538190", "map_id": "none", "name": "Ub-ERBB2:ERBIN:HSP90:CDC37", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10530998", "map_id": "Q23639", "name": "cul-5", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00000840", "map_id": "WBGene00000840", "name": "cul-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10538188", "map_id": "none", "name": "CHIP (STUB1) mediates ubiquitination of ERBB2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10538185", "map_id": "none", "name": "Ub-ERBB2:ERBIN:Ub-HSP90:CDC37", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10512456", "map_id": "none", "name": "PDGF-AA clevage by Furin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10512452", "map_id": "none", "name": "proPDGF-AA dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "species_10512392", "map_id": "none", "name": "active PDGF-AA dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10512454", "map_id": "Q9N413", "name": "pvf-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "reaction_10520337", "map_id": "none", "name": "Nck binds to the active PDGF receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10518510", "map_id": "Q95PX0", "name": "nck-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10512404", "map_id": "none", "name": "PDGF:Phospho-PDGF receptor dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10520335", "map_id": "none", "name": "PDGF:Phospho-PDGFR receptor dimer:Nck", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10512466", "map_id": "none", "name": "PI3K catalyses the phosphorylation of PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10512444", "map_id": "none", "name": "PDGF:Phospho-PDGF receptor dimer:PI3K", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10535202", "map_id": "none", "name": "Phosphorylation of PLCgamma by PDGFR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10512408", "map_id": "none", "name": "PDGF:Phospho-PDGF receptor dimer:PLC-gamma", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10535197", "map_id": "none", "name": "PDGF:p-PDGFR dimer:p-PLCgamma", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10519939", "map_id": "none", "name": "STAT binds to the active receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10519935", "map_id": "none", "name": "STAT family members", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10519937", "map_id": "none", "name": "PDGF:phospho-PDGF receptor dimer:STAT", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10512484", "map_id": "none", "name": "SH2 domain of Src binds to the active receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10512480", "map_id": "none", "name": "Homologues of MyrG-SRC", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10512482", "map_id": "none", "name": "PDGF:Phospho-PDGF receptor dimer:MyrG-SRC", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10512488", "map_id": "none", "name": "GRB2:SOS1 complex binds to the active receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10512486", "map_id": "none", "name": "PDGF:Phospho-PDGF receptor dimer:Grb2:Sos1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10512410", "map_id": "none", "name": "PLC-gamma binds to the active receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10512406", "map_id": "Q22070", "name": "plc-3", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10512491", "map_id": "none", "name": "SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10519901", "map_id": "none", "name": "Activation of Src", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10519898", "map_id": "none", "name": "PDGF:Phospho-PDGF receptor dimer:MyrG-p-Y419-SRC", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10512446", "map_id": "none", "name": "PI3-kinase binds to the active receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10535199", "map_id": "none", "name": "Activated PLC gamma dissociates from the PDGF receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10515233", "map_id": "Q22070", "name": "phospho-plc-3", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10520319", "map_id": "none", "name": "Crk binds to the active PDGF receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10520271", "map_id": "none", "name": "PDGF:Phospho-PDGF receptor dimer:Crk", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10573065", "map_id": "none", "name": "PDGFRs bind type I TKI", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10520554", "map_id": "none", "name": "PDGF alpha receptor: PDGF dimers", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_9674075", "map_id": "none", "name": "type I PDGFR-binding tyrosine kinase inhibitors", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10520559", "map_id": "none", "name": "PDGFR:type I PDGFR-binding TKIs", "type": "inhibitor", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10573067", "map_id": "none", "name": "PDGFRs bind type II TKI", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_9674079", "map_id": "none", "name": "type II PDGFR-binding tyrosine kinase inhibitors", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10512424", "map_id": "none", "name": "PDGFRA, PDGFRB", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10512436", "map_id": "none", "name": "PDGFR:type II PDGFR-binding TKIs", "type": "inhibitor", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10520333", "map_id": "none", "name": "Release of novel PDGFs as latent factors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10520321", "map_id": "none", "name": "Novel PDGF precursor dimers (CC, DD)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "species_10520331", "map_id": "none", "name": "Novel PDGF precursor dimers (CC, DD)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10566190", "map_id": "none", "name": "PDGF-BB clevage by Furin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10520297", "map_id": "none", "name": "proPDGF-BB dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "species_10512398", "map_id": "none", "name": "active PDGF-BB dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10566186", "map_id": "Q9N413", "name": "pvf-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "reaction_10512463", "map_id": "none", "name": "Autophosphorylation of PDGF beta receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10512458", "map_id": "none", "name": "PDGF beta receptor:PDGF chain B homodimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10512460", "map_id": "none", "name": "Phospho PDGF beta receptor: PDGF chain B homodimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10566192", "map_id": "none", "name": "PDGF-AB clevage by Furin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10520299", "map_id": "none", "name": "proPDGF-AB dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "species_10512400", "map_id": "none", "name": "PDGF A/B heterodimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10520561", "map_id": "none", "name": "Autophosphorylation of PDGF alpha receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10520556", "map_id": "none", "name": "Phospho PDGF alpha receptor:PDGF dimers", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10520311", "map_id": "none", "name": "Translocation of PDGF from ER to Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10520293", "map_id": "none", "name": "PDGF precursor dimers (AA, BB, A/B, CC, DD)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "species_10520309", "map_id": "none", "name": "PDGF precursor dimers (AA, BB, A/B, CC, DD)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "reaction_10512440", "map_id": "none", "name": "PDGF dimer binds two receptors simultaneously", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10512402", "map_id": "none", "name": "Active PDGF dimers (AA, AB, BB)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10512434", "map_id": "none", "name": "PDGF:PDGF receptor dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10512438", "map_id": "none", "name": "PDGFRA:olaratumab", "type": "inhibitor", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10520571", "map_id": "none", "name": "Autophosphorylation of PDGF alpha/beta receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10520566", "map_id": "none", "name": "PDGF alpha/beta:PDGF AB and BB dimers", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10520568", "map_id": "none", "name": "Phospho PDGF alpha-beta dimer:PDGF AB or BB dimers", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10520317", "map_id": "none", "name": "PDGF binds to extracellular matrix proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10512396", "map_id": "Q9N413", "name": "pvf-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10520313", "map_id": "none", "name": "Extracellular matrix ligands", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "CHEBI:18137", "map_id": "CHEBI:18137", "name": "CHEBI:18137", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:17421", "map_id": "CHEBI:17421", "name": "CHEBI:17421", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10520315", "map_id": "none", "name": "PDGF A and B chains:ECM complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10533137", "map_id": "none", "name": "PTP-RO interacts with p-c-Kit complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10533133", "map_id": "none", "name": "Homologues of PTPRU", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "G5EC69", "map_id": "G5EC69", "name": "PTPRU", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q20019", "map_id": "Q20019", "name": "PTPRU", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q21522", "map_id": "Q21522", "name": "PTPRU", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10516216", "map_id": "none", "name": "Homologues of KIT", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10533135", "map_id": "none", "name": "PTPRU:KIT", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10573104", "map_id": "none", "name": "KIT binds ripretinib", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_9674322", "map_id": "none", "name": "ripretinib", "type": "reactant", "sub_type": "other", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10573102", "map_id": "none", "name": "KIT:ripretinib", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10533140", "map_id": "none", "name": "Activation of RAS by p-KIT bound SOS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10516244", "map_id": "none", "name": "GRB2:SOS1:p-KIT complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10533155", "map_id": "none", "name": "PKC alpha interacts with and phosphorylates KIT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10533152", "map_id": "none", "name": "p-KIT (S741,746):PKC alpha", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10516248", "map_id": "none", "name": "Recruitment of CBL to KIT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10516246", "map_id": "none", "name": "CBL:Grb2/p-APS:p-c-Kit complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10533180", "map_id": "none", "name": "Synthesis of PIP3 from PIP2 by PI3K", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10533177", "map_id": "none", "name": "PI3K:p-KIT:sSCF dimer:p-KIT,PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10533119", "map_id": "none", "name": "Activation of RAC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10533116", "map_id": "none", "name": "p-VAV1:PIP3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10573054", "map_id": "none", "name": "KIT binds type II TKIs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_9669722", "map_id": "none", "name": "type II KIT binding TKIs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10573052", "map_id": "none", "name": "KIT:type II TKIs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10506848", "map_id": "none", "name": "Endosome acidification", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17940", "compartment_display": "endosome" }, { "id": "species_74722", "map_id": "CHEBI:15378", "name": "H+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_171907", "compartment_display": "endosome lumen", "complex": "false" }, { "id": "species_10506845", "map_id": "none", "name": "V-ATPase:ATP6AP1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "true" }, { "id": "Q9TYW1", "map_id": "Q9TYW1", "name": "vha-19", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021952", "map_id": "WBGene00021952", "name": "vha-19", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10506866", "map_id": "none", "name": "Re-integration of insulin receptor into plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10506864", "map_id": "none", "name": "insulin receptor", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "true" }, { "id": "Q968Y9", "map_id": "Q968Y9", "name": "daf-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000898", "map_id": "WBGene00000898", "name": "daf-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10506690", "map_id": "none", "name": "Insulin receptor", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10551244", "map_id": "none", "name": "ATP6AP1 binds V-ATPase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_171062", "compartment_display": "early endosome membrane" }, { "id": "species_10506843", "map_id": "Q9TYW1", "name": "vha-19", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "false" }, { "id": "species_10506838", "map_id": "none", "name": "V-ATPase", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "true" }, { "id": "reaction_10555984", "map_id": "none", "name": "MAPK4,6 translocate to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10555976", "map_id": "none", "name": "MAPK4,6", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10555982", "map_id": "none", "name": "MAPK4,6", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10555986", "map_id": "none", "name": "MAPK4,6 translocate to the cytoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10520692", "map_id": "none", "name": "Activation of PAKs by RAC1 and CDC42", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10520690", "map_id": "none", "name": "PAK1,2,3:CDC42:GTP, RAC1:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10555989", "map_id": "none", "name": "MAPK6 is degraded by the 26S proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10555953", "map_id": "P39745", "name": "mpk-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10556932", "map_id": "none", "name": "CDC14A,B bind MAPK6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10556926", "map_id": "P81299", "name": "cdc-14", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00000383", "map_id": "WBGene00000383", "name": "cdc-14", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10556924", "map_id": "P39745", "name": "phospho-mpk-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10556930", "map_id": "none", "name": "p-3S,T MAPK6:CDC14A,B", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "P81299", "map_id": "P81299", "name": "cdc-14", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10556937", "map_id": "none", "name": "CDC14A,B dephosphorylate p-3S,T MAPK6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10556934", "map_id": "none", "name": "MAPK6:CDC14A,B", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10555993", "map_id": "none", "name": "p-S215 FOXO3 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10555974", "map_id": "O16850", "name": "phospho-daf-16", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10555970", "map_id": "O16850", "name": "phospho-daf-16", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10555963", "map_id": "none", "name": "PAK1,2,3 phosphorylates MAPK6,4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10555955", "map_id": "P39745", "name": "mpk-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10555958", "map_id": "P39745", "name": "phospho-mpk-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10556940", "map_id": "none", "name": "CDK1 phosphorylates MAPK6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10555980", "map_id": "P39745", "name": "mpk-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10511154", "map_id": "P34556", "name": "phospho-cdk-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10555185", "map_id": "none", "name": "Activated MAPK phosphorylates RAF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10554998", "map_id": "Q07292", "name": "phospho-lin-45", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10555183", "map_id": "Q07292", "name": "phospho-lin-45", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10555193", "map_id": "none", "name": "Activated MAPKs phosphorylate BRAF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10555000", "map_id": "Q07292", "name": "phospho-lin-45", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10555191", "map_id": "Q07292", "name": "phospho-lin-45", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10555176", "map_id": "none", "name": "Activated MAPKs phosphorylate MAP2K1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10555059", "map_id": "none", "name": "p-2S MAP2K1:p-2S MAPK2K2 heterodimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10555173", "map_id": "none", "name": "p-2S,T MAP2K1:p-2S MAPK2K2 heterodimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10555140", "map_id": "none", "name": "PAQR3 binds inactive RAFs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10554946", "map_id": "Q07292", "name": "phospho-lin-45", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10555136", "map_id": "Q9U1V1", "name": "paqr-3", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "WBGene00013457", "map_id": "WBGene00013457", "name": "paqr-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10555138", "map_id": "none", "name": "PAQR3:inactive RAFs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "Q9U1V1", "map_id": "Q9U1V1", "name": "paqr-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10555236", "map_id": "none", "name": "PP2A dephosphorylates RAF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10555230", "map_id": "none", "name": "p21RAS:GTP:dephosphorylated RAF1 homo/heterodimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10555234", "map_id": "none", "name": "p21RAS:GTP:p-S621 RAF1 homo/heterodimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10555110", "map_id": "none", "name": "BRAP autoubiquitinates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10555100", "map_id": "none", "name": "p21 RAS:GTP:BRAP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q95QN6", "map_id": "Q95QN6", "name": "brap-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017144", "map_id": "WBGene00017144", "name": "brap-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10555107", "map_id": "none", "name": "p21 RAS:GTP:ub-BRAP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10566377", "map_id": "none", "name": "PTPN3 binds p-T183,Y185 MAPK12", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10525306", "map_id": "none", "name": "Homologues of p-T183,Y185-MAPK12", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10566373", "map_id": "P28191", "name": "ptp-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10566375", "map_id": "none", "name": "PTPN3:p-T183,Y185-MAPK12", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P28191", "map_id": "P28191", "name": "ptp-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10566488", "map_id": "none", "name": "MAPK12 phosphorylates PTPN3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10566485", "map_id": "none", "name": "p-S459 PTPN3:p-T183,Y185-MAPK12", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10555226", "map_id": "none", "name": "PEBP1 binds activated RAF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10555049", "map_id": "O16264", "name": "PEBP1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10555245", "map_id": "none", "name": "PP5 dephosphorylates RAF1 S338", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10555242", "map_id": "Q9NES8", "name": "pph-5", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00012665", "map_id": "WBGene00012665", "name": "pph-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10566380", "map_id": "none", "name": "PTPN3 dephosphorylates MAPK12", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10526147", "map_id": "none", "name": "Homologues of MAPK12", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10555102", "map_id": "none", "name": "BRAP binds RAS:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10555098", "map_id": "Q95QN6", "name": "brap-2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10572703", "map_id": "none", "name": "RAS intrinsic GTPase activity hydrolyzes GTP to GDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10572700", "map_id": "none", "name": "Intrinsic nucleotide exchange on RAS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10572741", "map_id": "none", "name": "Raf dimer inhibitors bind RAF heterodimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_9657579", "map_id": "none", "name": "RAF dimer inhibitors", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10554994", "map_id": "none", "name": "p21 RAS:GTP:homo/heterodimerized RAF complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10554964", "map_id": "none", "name": "YWHAB dimer dissociates from dephosphorylated RAF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10554962", "map_id": "none", "name": "dephosphorylated inactive RAFS:YWHAB dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10507067", "map_id": "none", "name": "YWHAB dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10554906", "map_id": "Q07292", "name": "phospho-lin-45", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10554996", "map_id": "none", "name": "RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10554935", "map_id": "none", "name": "p21 RAS:GTP:'activator' RAF:YWHAB dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10554967", "map_id": "none", "name": "PP2A dephosphorylates inactive RAFs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10554954", "map_id": "none", "name": "inactive RAFs:YWHAB dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10572954", "map_id": "none", "name": "MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10572951", "map_id": "none", "name": "S-GCC MRAS:GTP:SHOC2:PP1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "P48727", "map_id": "P48727", "name": "gsp-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001748", "map_id": "WBGene00001748", "name": "gsp-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q22875", "map_id": "Q22875", "name": "soc-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004929", "map_id": "WBGene00004929", "name": "soc-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EGA7", "map_id": "G5EGA7", "name": "ras-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004311", "map_id": "WBGene00004311", "name": "ras-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10554956", "map_id": "none", "name": "Inactive RAFs bind YWHAB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10554942", "map_id": "none", "name": "\"Activator\" RAF:YWHAB dimer binds RAS:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10554933", "map_id": "none", "name": "'activator' RAF:YWHAB dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10554940", "map_id": "Q9BKU4", "name": "phb-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00004014", "map_id": "WBGene00004014", "name": "phb-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10572966", "map_id": "none", "name": "RAS:GTP binds RAL GDS proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10572962", "map_id": "none", "name": "S-Farn-Me-2xPalmS HRAS:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10572964", "map_id": "none", "name": "S-Farn-Me_2xPalmS HRAS:GTP:RAL GDS proteins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10572576", "map_id": "none", "name": "ICMT methylates S-Farn RAS proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10572567", "map_id": "P22981", "name": "let-60", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10572572", "map_id": "P22981", "name": "let-60", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10572574", "map_id": "none", "name": "ICMT:Zn2+:Cysmethynil", "type": "inhibitor", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10572896", "map_id": "none", "name": "Calmodulin dissociates KRAS4B from the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10572894", "map_id": "none", "name": "S-Farn-Me KRAS4B:CALM1:4xCa2+", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10572610", "map_id": "none", "name": "S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10572592", "map_id": "P22981", "name": "let-60", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "species_10572607", "map_id": "none", "name": "ZDHHC9:GOLGA7", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "Q9XWD7", "map_id": "Q9XWD7", "name": "dhhc-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012948", "map_id": "WBGene00012948", "name": "dhhc-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10572612", "map_id": "none", "name": "FNTB inhibitors bind FNTA:FNTB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9653479", "map_id": "none", "name": "FNTB inhibitors", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10572587", "map_id": "none", "name": "FNTA:FNTB:FTase inhibitors", "type": "inhibitor", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10572679", "map_id": "none", "name": "RCE1 cleaves S-Farn proRAS proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10572583", "map_id": "P22981", "name": "let-60", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10572676", "map_id": "G5EEP3", "name": "fce-2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "WBGene00001406", "map_id": "WBGene00001406", "name": "fce-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10572902", "map_id": "none", "name": "ARL2:GTP bind PDE6D on KRAS4B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10572898", "map_id": "none", "name": "S-Farn-Me KRAS4B:CALM1:4xCa2+:PDE6D", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q18268", "map_id": "Q18268", "name": "pdl-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003966", "map_id": "WBGene00003966", "name": "pdl-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10550993", "map_id": "none", "name": "ARL2:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q19705", "map_id": "Q19705", "name": "evl-20", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001358", "map_id": "WBGene00001358", "name": "evl-20", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10572900", "map_id": "none", "name": "S-Farn-Me KRAS4B:CALM1:4xCa2+:PDE6D:ARL2:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10572906", "map_id": "none", "name": "PDE6D binds S-Farn-Me KRAS4B:CALM:4 Ca2+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10553585", "map_id": "Q18268", "name": "pdl-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10572904", "map_id": "none", "name": "PDE6D:Deltarasin", "type": "inhibitor", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10572589", "map_id": "none", "name": "pro-RAS proteins are farnesylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10572579", "map_id": "P22981", "name": "let-60", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10572909", "map_id": "none", "name": "KRAS4B recycles to the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10511479", "map_id": "P22981", "name": "let-60", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10572753", "map_id": "none", "name": "KRAS4B is phosphorylated on serine 181", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10572744", "map_id": "P22981", "name": "phospho-let-60", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10572750", "map_id": "none", "name": "PKCZ,PRKG2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "H2KYN2", "map_id": "H2KYN2", "name": "pkg-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00015650", "map_id": "WBGene00015650", "name": "pkg-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O76360", "map_id": "O76360", "name": "egl-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001173", "map_id": "WBGene00001173", "name": "egl-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10572881", "map_id": "none", "name": "S-Farn-Me KRAS4B binds calmodulin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10572598", "map_id": "none", "name": "mature RAS proteins translocate to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10511477", "map_id": "P22981", "name": "let-60", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10572886", "map_id": "none", "name": "pS181-S-Farn-Me KRAS4B translocates to the outer mitochondrial membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane" }, { "id": "species_10572884", "map_id": "P22981", "name": "phospho-let-60", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "false" }, { "id": "reaction_10572696", "map_id": "none", "name": "Mature S-Farn-Me KRAS4B translocates to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "reaction_10572666", "map_id": "none", "name": "Palmostatin B binds RAS depalmitoylases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_9647934", "map_id": "none", "name": "Palmostatin B", "type": "reactant", "sub_type": "other", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10572662", "map_id": "none", "name": "LYPLA1 dimer, ABHD17A,B,C", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9XVA7", "map_id": "Q9XVA7", "name": "ABHD17B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00044003", "map_id": "WBGene00044003", "name": "ABHD17B", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q21221", "map_id": "Q21221", "name": "aho-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00045192", "map_id": "WBGene00045192", "name": "aho-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q5FC17", "map_id": "Q5FC17", "name": "ABHD17B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7JKU8", "map_id": "Q7JKU8", "name": "ABHD17B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9BL52", "map_id": "Q9BL52", "name": "ABHD17B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A061ACY0", "map_id": "A0A061ACY0", "name": "ath-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010564", "map_id": "WBGene00010564", "name": "ath-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10572664", "map_id": "none", "name": "Palmostatin B:LYPLA1 dimer, ABHD17A,B,C", "type": "inhibitor", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10572698", "map_id": "none", "name": "mature p21 RAS binds GDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10511471", "map_id": "P22981", "name": "let-60", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10572890", "map_id": "none", "name": "pS181-S-Farn-Me KRAS4B binds BCL2L1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane" }, { "id": "species_10528114", "map_id": "P41958", "name": "ced-9", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "false" }, { "id": "WBGene00000423", "map_id": "WBGene00000423", "name": "ced-9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10572888", "map_id": "none", "name": "p-S181-S-Farn-Me KRAS4B:BCL2L1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "true" }, { "id": "P41958", "map_id": "P41958", "name": "ced-9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10572669", "map_id": "none", "name": "RAS proteins are depalmitoylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_8848337", "map_id": "CHEBI:7896", "name": "PALM(-)", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10554992", "map_id": "none", "name": "RAS GEFs promote RAS nucleotide exchange", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10554989", "map_id": "none", "name": "RAS GEFs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "W6RS10", "map_id": "W6RS10", "name": "RASGEF1A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019902", "map_id": "WBGene00019902", "name": "RASGEF1A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7YZG5", "map_id": "Q7YZG5", "name": "PTPRA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021702", "map_id": "WBGene00021702", "name": "PTPRA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "C6KRM7", "map_id": "C6KRM7", "name": "rig-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004372", "map_id": "WBGene00004372", "name": "rig-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EDB9", "map_id": "G5EDB9", "name": "pxf-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004254", "map_id": "WBGene00004254", "name": "pxf-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10572929", "map_id": "none", "name": "RAS:GTP binds PI3K", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10572927", "map_id": "none", "name": "p21 RAS:GTP:PI3K", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10542176", "map_id": "none", "name": "Translocation of WWTR1 (TAZ) to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10542174", "map_id": "Q19404", "name": "yap-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10542432", "map_id": "none", "name": "DVL2 binds phosphorylated WWTR1 (TAZ)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10541986", "map_id": "Q19404", "name": "phospho-yap-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10542430", "map_id": "none", "name": "p-WWTR1:DVL2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10542178", "map_id": "none", "name": "Translocation of YAP1 to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10532633", "map_id": "Q19404", "name": "yap-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10542339", "map_id": "none", "name": "Translocation of YAP1:ZO-2 (TJP2) to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10542333", "map_id": "none", "name": "YAP1:TJP2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q8I103", "map_id": "Q8I103", "name": "zoo-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013683", "map_id": "WBGene00013683", "name": "zoo-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10542337", "map_id": "none", "name": "YAP1:TJP2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10541988", "map_id": "none", "name": "Phosphorylation of WWTR1 (TAZ) by LATS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10541961", "map_id": "none", "name": "p-LATS2:p-MOB1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "O45797", "map_id": "O45797", "name": "phospho-wts-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007047", "map_id": "WBGene00007047", "name": "phospho-wts-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q20186", "map_id": "Q20186", "name": "phospho-mob-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009551", "map_id": "WBGene00009551", "name": "phospho-mob-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10542345", "map_id": "none", "name": "WWTR1 (TAZ) binds ZO-1 (TJP1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10542341", "map_id": "Q8I103", "name": "zoo-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10542343", "map_id": "none", "name": "WWTR1:TJP1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10541964", "map_id": "none", "name": "Phosphorylation of YAP by LATS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10541959", "map_id": "Q19404", "name": "phospho-yap-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10542349", "map_id": "none", "name": "WWTR1 (TAZ) binds ZO-2 (TJP2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10542331", "map_id": "Q8I103", "name": "zoo-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10542347", "map_id": "none", "name": "WWTR1:TJP2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10542351", "map_id": "none", "name": "YAP1 binds ZO-2 (TJP2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10541973", "map_id": "none", "name": "Phosphorylation of YAP by LATS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10541970", "map_id": "Q19404", "name": "phospho-yap-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10541956", "map_id": "none", "name": "p-LATS:p-MOB", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10542327", "map_id": "none", "name": "NPHP4 protein binds LATS proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10541935", "map_id": "O45797", "name": "wts-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10542323", "map_id": "G5ECP0", "name": "nphp-4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00011261", "map_id": "WBGene00011261", "name": "nphp-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10542325", "map_id": "none", "name": "NPHP4:LATS", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "G5ECP0", "map_id": "G5ECP0", "name": "nphp-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10541975", "map_id": "none", "name": "Phosphorylated MOB1A proteins associate with LATS proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10541944", "map_id": "Q20186", "name": "phospho-mob-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10541946", "map_id": "none", "name": "LATS:p-MOB", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10542329", "map_id": "none", "name": "Phosphorylation of WWTR1 (TAZ) by LATS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10541981", "map_id": "none", "name": "YWHAB (14-3-3 beta/alpha) dimer binds phosphorylated YAP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10541979", "map_id": "none", "name": "p-YAP1:YWHAB", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10573312", "map_id": "none", "name": "RHOBTB3 binds interacting proteins at trans-Golgi network", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane" }, { "id": "species_10573308", "map_id": "none", "name": "RHOBTB3 interacting proteins", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10573304", "map_id": "none", "name": "RHOBTB3:ATP", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane", "complex": "true" }, { "id": "species_10573310", "map_id": "none", "name": "RHOBTB3:ATP:RHOBTB3 interacting proteins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane", "complex": "true" }, { "id": "reaction_10573314", "map_id": "none", "name": "RHOBTB3 binds ATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane" }, { "id": "species_10573302", "map_id": "none", "name": "Homologues of RHOBTB3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane", "complex": "true" }, { "id": "reaction_10573319", "map_id": "none", "name": "RHOBTB3 hydrolyzes ATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane" }, { "id": "species_10573316", "map_id": "none", "name": "RHOBTB3:ADP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane", "complex": "true" }, { "id": "reaction_10571460", "map_id": "none", "name": "RHOT1 binds effectors at the mitochondrial outer membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane" }, { "id": "species_10571454", "map_id": "P91503", "name": "trak-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00020838", "map_id": "WBGene00020838", "name": "trak-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10571444", "map_id": "none", "name": "RHOT1:GTP", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "true" }, { "id": "Q94263", "map_id": "Q94263", "name": "miro-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019544", "map_id": "WBGene00019544", "name": "miro-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10571458", "map_id": "none", "name": "RHOT1:GTP:RHOT1 effectors", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "true" }, { "id": "P91503", "map_id": "P91503", "name": "trak-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10571449", "map_id": "none", "name": "RHOT1 hydrolyzes GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10571446", "map_id": "none", "name": "RHOT1:GDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "true" }, { "id": "reaction_10571466", "map_id": "none", "name": "RHOT2 binds effectors at the mitochondrial outer membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10571462", "map_id": "none", "name": "RHOT2 effectors", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10571464", "map_id": "none", "name": "RHOT2:GTP:RHOT2 effectors", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "true" }, { "id": "reaction_10571468", "map_id": "none", "name": "RHOT2 hydrolyzes GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10564802", "map_id": "none", "name": "PTK6 binds ARHGAP35", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10564606", "map_id": "none", "name": "Homologues of p-Y342-PTK6", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "A0A0K3ARA3", "map_id": "A0A0K3ARA3", "name": "phospho-p-Y342-PTK6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020106", "map_id": "WBGene00020106", "name": "phospho-p-Y342-PTK6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q10925", "map_id": "Q10925", "name": "phospho-sid-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002207", "map_id": "WBGene00002207", "name": "phospho-sid-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10521590", "map_id": "O45611", "name": "rga-5", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10564800", "map_id": "none", "name": "p-Y342-PTK6:ARHGAP35", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10564808", "map_id": "none", "name": "PTK6 phosphorylates ARHGAP35", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10564805", "map_id": "O45611", "name": "phospho-rga-5", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10564731", "map_id": "none", "name": "Activation of RAC1 by the PXN:CRK complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10564728", "map_id": "none", "name": "p-Y31,Y118-PXN:CRK:DOCK180:ELMO1,ELMO2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q8STE5", "map_id": "Q8STE5", "name": "ced-12", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000426", "map_id": "WBGene00000426", "name": "ced-12", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10564813", "map_id": "none", "name": "ARHGAP35 stimulates RHOA GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10564810", "map_id": "none", "name": "p-Y1105-ARHGAP35:RHOA:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10564815", "map_id": "none", "name": "ARHGAP35 binds RHOA:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10564769", "map_id": "none", "name": "PTK6 phosphorylates CBL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10564784", "map_id": "none", "name": "PTK6 binds ARAP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10564780", "map_id": "H2KZV4", "name": "ARAP1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10564782", "map_id": "none", "name": "p-Y342-PTK6:ARAP1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10564754", "map_id": "none", "name": "PTK6 phosphorylates AKT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10564733", "map_id": "none", "name": "p-Y342-PTK6:AKT1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10564751", "map_id": "none", "name": "p-Y342-PTK6:p-Y315,Y326-AKT1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10564775", "map_id": "none", "name": "CBL autoubiquitinates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10564772", "map_id": "Q19019", "name": "phospho-sli-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10564790", "map_id": "none", "name": "PTK6 phosphorylates ARAP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10564787", "map_id": "H2KZV4", "name": "phospho-p-Y231-ARAP1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10564760", "map_id": "none", "name": "PTK6 binds DOK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10564756", "map_id": "E6N0V1", "name": "rog-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10564758", "map_id": "none", "name": "p-Y342-PTK6:DOK1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10564735", "map_id": "none", "name": "PTK6 binds AKT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10564766", "map_id": "none", "name": "PTK6 phosphorylates DOK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10564763", "map_id": "E6N0V1", "name": "phospho-rog-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10564930", "map_id": "none", "name": "PTK6 phosphorylates SFPQ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10564924", "map_id": "B3GWA1", "name": "nono-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00017778", "map_id": "WBGene00017778", "name": "phospho-nono-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10564927", "map_id": "B3GWA1", "name": "phospho-nono-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10564796", "map_id": "none", "name": "Homologues of p-Y342-PTK6", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10564798", "map_id": "none", "name": "PTK6 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10564828", "map_id": "none", "name": "SRMS phosphorylates PTK6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10564823", "map_id": "none", "name": "Homologues of p-Y342,Y447-PTK6", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10564825", "map_id": "A0A0K3ARA3", "name": "SRMS", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10564610", "map_id": "none", "name": "SOCS3 binds activated PTK6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10531061", "map_id": "O45498", "name": "SOCS3", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00009556", "map_id": "WBGene00009556", "name": "SOCS3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10564608", "map_id": "none", "name": "p-Y342-PTK6:SOCS3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "O45498", "map_id": "O45498", "name": "SOCS3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10515265", "map_id": "none", "name": "I-Smad competes with Co-Smad for R-Smad1/5/8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_947587", "compartment_display": "cytoplasmic side of plasma membrane" }, { "id": "species_10515259", "map_id": "G5EDS9", "name": "tag-68", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10514789", "map_id": "none", "name": "p-2S-SMAD1/5/8", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q02330", "map_id": "Q02330", "name": "phospho-sma-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004856", "map_id": "WBGene00004856", "name": "phospho-sma-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "F5GUE5", "map_id": "F5GUE5", "name": "phospho-daf-14", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000910", "map_id": "WBGene00000910", "name": "phospho-daf-14", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P45896", "map_id": "P45896", "name": "phospho-sma-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004857", "map_id": "WBGene00004857", "name": "phospho-sma-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10515263", "map_id": "none", "name": "I-SMAD:p-2S-SMAD1/5/8", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10514817", "map_id": "none", "name": "Ubiquitin-dependent degradation of the Smad complex terminates BMP2 signalling", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10514815", "map_id": "none", "name": "p-2S-SMAD1/5/8:SMAD4", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10514839", "map_id": "none", "name": "The phospho-R-Smad1/5/8:Co-Smad transfers to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13231", "compartment_display": "nuclear envelope" }, { "id": "species_10514791", "map_id": "none", "name": "p-2S-SMAD1/5/8:SMAD4", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10514793", "map_id": "none", "name": "Phospho-R-Smad1/5/8 forms a complex with Co-Smad", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10571958", "map_id": "none", "name": "NICD4 traffics to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13231", "compartment_display": "nuclear envelope" }, { "id": "species_10571948", "map_id": "Q21850", "name": "NICD4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10517150", "map_id": "Q21850", "name": "NICD4", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10571956", "map_id": "none", "name": "p-4S-NICD4:YWHAZ dimer", "type": "inhibitor", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10571961", "map_id": "none", "name": "AKT1 phosphorylates NOTCH4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10571954", "map_id": "Q21850", "name": "phospho-p-4S-NICD4", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10546960", "map_id": "none", "name": "WNT ligands traffic to the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10546918", "map_id": "none", "name": "WLS:WNT", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "P34888", "map_id": "P34888", "name": "cwn-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000857", "map_id": "WBGene00000857", "name": "cwn-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7YWX7", "map_id": "Q7YWX7", "name": "mig-14", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003246", "map_id": "WBGene00003246", "name": "mig-14", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10546940", "map_id": "none", "name": "WLS:WNT", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10548112", "map_id": "none", "name": "WLS:WNT complex is internalized for maturation into exosomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10548088", "map_id": "none", "name": "WLS:WNT", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_3828050", "compartment_display": "multivesicular body, internal vesicle", "complex": "true" }, { "id": "reaction_10546848", "map_id": "none", "name": "Retromer recycles WLS to the Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10546842", "map_id": "none", "name": "WLS:retromer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_171062", "compartment_display": "early endosome membrane", "complex": "true" }, { "id": "Q9XW41", "map_id": "Q9XW41", "name": "snx-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006503", "map_id": "WBGene00006503", "name": "snx-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O01258", "map_id": "O01258", "name": "vps-26", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006931", "map_id": "WBGene00006931", "name": "vps-26", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86D99", "map_id": "Q86D99", "name": "vps-29", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00014234", "map_id": "WBGene00014234", "name": "vps-29", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q21053", "map_id": "Q21053", "name": "vps-35", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006933", "map_id": "WBGene00006933", "name": "vps-35", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10546846", "map_id": "none", "name": "WLS:retromer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "reaction_10546913", "map_id": "none", "name": "WNT ligands traffic to the Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "species_10546890", "map_id": "none", "name": "palmitoleyl-N-glycosylated WNTs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "species_10546906", "map_id": "none", "name": "palmitoleyl-N-glycosylated WNTs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "species_10546911", "map_id": "Q21336", "name": "tmed-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "WBGene00010670", "map_id": "WBGene00010670", "name": "tmed-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10546962", "map_id": "none", "name": "WLS is endocytosed to the early endosome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_171062", "compartment_display": "early endosome membrane" }, { "id": "species_10546922", "map_id": "Q7YWX7", "name": "mig-14", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10546835", "map_id": "Q7YWX7", "name": "mig-14", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_171062", "compartment_display": "early endosome membrane", "complex": "false" }, { "id": "reaction_10546916", "map_id": "none", "name": "Retromer associates with WLS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_171062", "compartment_display": "early endosome membrane" }, { "id": "species_10546830", "map_id": "none", "name": "VPS35:VPS29:VPS26", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10546840", "map_id": "Q9XW41", "name": "snx-3", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10546964", "map_id": "none", "name": "WLS dissociates from retromer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10546844", "map_id": "Q7YWX7", "name": "mig-14", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "reaction_10546920", "map_id": "none", "name": "WLS binds WNT ligands in the Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "reaction_10548110", "map_id": "none", "name": "WNTs are secreted in exosomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_383505", "compartment_display": "extracellular exosome" }, { "id": "species_10548108", "map_id": "none", "name": "WLS:WNT", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_383505", "compartment_display": "extracellular exosome", "complex": "true" }, { "id": "reaction_10546958", "map_id": "none", "name": "secretion of WNT ligands", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10546956", "map_id": "none", "name": "WNTs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "G5EG05", "map_id": "G5EG05", "name": "egl-20", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001188", "map_id": "WBGene00001188", "name": "egl-20", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10549441", "map_id": "none", "name": "DVL1 is ubiquitinated by HECW1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10549434", "map_id": "none", "name": "DVL1:HECW1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q09291", "map_id": "Q09291", "name": "hecw-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009738", "map_id": "WBGene00009738", "name": "hecw-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10549438", "map_id": "none", "name": "ub-DVL1:HECW1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10549445", "map_id": "none", "name": "Ubiquitinated DVL1 is degraded by the proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10549432", "map_id": "Q09291", "name": "hecw-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10535195", "map_id": "none", "name": "DVL is ubiquitinated by CUL3:KLHL12:RBX1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10535167", "map_id": "none", "name": "DVL:CUL3:KLHL12:RBX1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10535192", "map_id": "none", "name": "ub-DVL:CUL3:KLHL12:RBX1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10549436", "map_id": "none", "name": "DVL1 is bound by the HECT ubiquitin ligase HECW1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10515040", "map_id": "none", "name": "Homologues of DVL1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10547556", "map_id": "none", "name": "SET1 complex trimethylates H3K4 at the MYC gene", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10547529", "map_id": "none", "name": "MYC gene: H2B K121ub nucleosome", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10547533", "map_id": "none", "name": "MYC gene:H2B K121ub H3K4me3 nucleosome", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10547553", "map_id": "none", "name": "TCF/LEF:CTNNB1:BCL9:PYGO:SET1-like complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "O44447", "map_id": "O44447", "name": "PYGO1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00015330", "map_id": "WBGene00015330", "name": "PYGO1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10547174", "map_id": "none", "name": "Beta-catenin displaces TLE:HDAC1 from TCF/LEF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10514938", "map_id": "O44326", "name": "hmp-2", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10547170", "map_id": "none", "name": "TCF/LEF:TLE:HDAC1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10547387", "map_id": "none", "name": "Beta-catenin recruits CDC73 and LEO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10509311", "map_id": "Q9N5U5", "name": "cdc-73", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00018064", "map_id": "WBGene00018064", "name": "cdc-73", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10509321", "map_id": "Q17431", "name": "leo-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00007110", "map_id": "WBGene00007110", "name": "leo-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10547385", "map_id": "none", "name": "TCF/LEF:CTNNB1:PAF1-like complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q17431", "map_id": "Q17431", "name": "leo-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9N5U5", "map_id": "Q9N5U5", "name": "cdc-73", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10547391", "map_id": "none", "name": "Beta-catenin recruits CBP/p300", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10532226", "map_id": "P34545", "name": "cbp-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10547389", "map_id": "none", "name": "TCF/LEF:CTNNB1:CBP/p300", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10514940", "map_id": "none", "name": "Beta-catenin translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10553858", "map_id": "none", "name": "Beta-catenin binds SOX proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10553854", "map_id": "none", "name": "SRY,SOX2,SOX3,SOX4,SOX6,SOX7,SOX9,SOX17", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q8T3B9", "map_id": "Q8T3B9", "name": "sem-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004771", "map_id": "WBGene00004771", "name": "sem-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A1N7SZG1", "map_id": "A0A1N7SZG1", "name": "sox-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00015716", "map_id": "WBGene00015716", "name": "sox-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q20201", "map_id": "Q20201", "name": "sox-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004950", "map_id": "WBGene00004950", "name": "sox-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q21305", "map_id": "Q21305", "name": "sox-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004949", "map_id": "WBGene00004949", "name": "sox-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q23045", "map_id": "Q23045", "name": "egl-13", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001182", "map_id": "WBGene00001182", "name": "egl-13", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10553856", "map_id": "none", "name": "CTNNB1:SRY,SOX2,SOX3,SOX4,SOX6,SOX7,SOX9,SOX17", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10554594", "map_id": "none", "name": "TCF:Beta-catenin binds SOX proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10554590", "map_id": "none", "name": "SOX4,SOX13,SOX17", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10554592", "map_id": "none", "name": "TCF/LEF:CTNNB1:SOX4,SOX13,SOX17", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10547479", "map_id": "none", "name": "beta-catenin is replaced by repression complexes at the promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10547475", "map_id": "none", "name": "TLE1:HDAC1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10547473", "map_id": "none", "name": "TCF/LEF:CTNNB1:APC:CTBP:BTRC", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10547477", "map_id": "none", "name": "APC:CTBP:CTNNB1:BTRC", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10547948", "map_id": "none", "name": "YWHAZ and XPO1 mediate the nuclear export of beta-catenin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10547940", "map_id": "none", "name": "XPO1:YWHAZ:p-S20-CBY1:CTNNB1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q23089", "map_id": "Q23089", "name": "xpo-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10547946", "map_id": "none", "name": "XPO1:YWHAZ:p-S20-CBY1:CTNNB1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10551790", "map_id": "none", "name": "CHD8 binds beta-catenin to negatively regulate WNT-dependent gene expression", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10551786", "map_id": "O61845", "name": "chd-7", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00007053", "map_id": "WBGene00007053", "name": "chd-7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10551788", "map_id": "none", "name": "CTNNB1:CHD8", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "O61845", "map_id": "O61845", "name": "chd-7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10524625", "map_id": "none", "name": "RhCG mediates ammonium influx into kidney collecting duct cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_140912", "map_id": "CHEBI:28938", "name": "NH4+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10524622", "map_id": "none", "name": "Homologues of RHCG", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10525188", "map_id": "none", "name": "RhCG mediates ammonium efflux out of kidney collecting duct cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10525190", "map_id": "none", "name": "RhBG mediates ammonium influx into kidney collecting duct cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10524636", "map_id": "Q22947", "name": "rhr-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10524634", "map_id": "none", "name": "RHAG transports NH4+ from cytosol to extracellular region (red blood cells)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10524639", "map_id": "none", "name": "RhBG mediates ammonium effflux out of kidney collecting duct cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10524112", "map_id": "none", "name": "NaDC3 co-transports the dicarboxylic acid succinate and three sodium ion", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_433123", "map_id": "CHEBI:30031", "name": "SUCCA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_29434", "map_id": "CHEBI:30031", "name": "SUCCA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10524109", "map_id": "none", "name": "Homologues of SLC13A3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "P32739", "map_id": "P32739", "name": "nac-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003518", "map_id": "WBGene00003518", "name": "nac-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P46556", "map_id": "P46556", "name": "SLC13A2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007138", "map_id": "WBGene00007138", "name": "SLC13A2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q21339", "map_id": "Q21339", "name": "nac-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003519", "map_id": "WBGene00003519", "name": "nac-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q93655", "map_id": "Q93655", "name": "nac-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003517", "map_id": "WBGene00003517", "name": "nac-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10524130", "map_id": "none", "name": "NaS1 co-transports sulphate and a sodium ion", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10524127", "map_id": "none", "name": "Homologues of SLC13A1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10524099", "map_id": "none", "name": "NaS2 co-transports sulphate and two sodium ions", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10524096", "map_id": "none", "name": "Homologues of SLC13A4", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10524117", "map_id": "none", "name": "NACT co-transports trivalent citrate and a sodium ion", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_433138", "map_id": "CHEBI:30769", "name": "CIT", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10524114", "map_id": "Q93655", "name": "nac-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10524143", "map_id": "none", "name": "NaDC1 co-transports dicarboxylic acids and a sodium ion", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_433111", "map_id": "none", "name": "Dicarboxylates transported by NaDC1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_1650769", "map_id": "CHEBI:30031", "name": "SUCCA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_433124", "map_id": "none", "name": "Dicarboxylates transported by NaDC1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10524140", "map_id": "none", "name": "Homologues of SLC13A2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10523391", "map_id": "none", "name": "HMIT co-transports myo-inositol with a proton", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_429130", "map_id": "CHEBI:17268", "name": "Ins", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_426910", "map_id": "CHEBI:17268", "name": "Ins", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10523388", "map_id": "Q21455", "name": "hmit-1.3", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "WBGene00010811", "map_id": "WBGene00010811", "name": "hmit-1.3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10524074", "map_id": "none", "name": "SOAT can transport taurolithocholate-3-sulphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_433120", "map_id": "CHEBI:17864", "name": "taurolithocholate sulfate", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10524071", "map_id": "Q33BL1", "name": "SLC10A6", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10524593", "map_id": "none", "name": "VMAT1/2 can mediate the transport of biogenic amines", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_444154", "map_id": "none", "name": "Biogenic amines transported by VMAT1/2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_444152", "map_id": "none", "name": "Biogenic amines transported by VMAT1/2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_374932", "compartment_display": "clathrin-sculpted monoamine transport vesicle lumen", "complex": "true" }, { "id": "species_10524590", "map_id": "Q9GNP0", "name": "cat-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_374940", "compartment_display": "clathrin-sculpted monoamine transport vesicle membrane", "complex": "false" }, { "id": "reaction_10524580", "map_id": "none", "name": "SLC6A2 cotransports NAd, Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_374935", "map_id": "CHEBI:18357", "name": "NAd", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10524577", "map_id": "Q03614", "name": "dat-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "WBGene00000934", "map_id": "WBGene00000934", "name": "dat-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10518791", "map_id": "none", "name": "Uptake of Noradrenaline", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10518786", "map_id": "Q19442", "name": "pes-23", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "WBGene00003987", "map_id": "WBGene00003987", "name": "pes-23", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10524651", "map_id": "none", "name": "Cho transports from the extracellular space to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_264638", "map_id": "CHEBI:15354", "name": "Cho", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10524644", "map_id": "Q20026", "name": "chtl-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10527456", "map_id": "none", "name": "OCT3 mediates renal clearance of organic cations", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_549326", "map_id": "none", "name": "OCT3 substrates", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:8428", "map_id": "CHEBI:8428", "name": "CHEBI:8428", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:46020", "map_id": "CHEBI:46020", "name": "CHEBI:46020", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:42820", "map_id": "CHEBI:42820", "name": "CHEBI:42820", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:47499", "map_id": "CHEBI:47499", "name": "CHEBI:47499", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:47781", "map_id": "CHEBI:47781", "name": "CHEBI:47781", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:641", "map_id": "CHEBI:641", "name": "CHEBI:641", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:46631", "map_id": "CHEBI:46631", "name": "CHEBI:46631", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_549255", "map_id": "none", "name": "OCT3 substrates", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10527453", "map_id": "Q19442", "name": "pes-23", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10527408", "map_id": "none", "name": "SLC22A4 cotransports ERGT, Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_549261", "map_id": "CHEBI:4828", "name": "ERGT", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_549260", "map_id": "CHEBI:4828", "name": "ERGT", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10527400", "map_id": "none", "name": "Homologues of SLC22A4", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q4PIX1", "map_id": "Q4PIX1", "name": "SLC22A5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00044455", "map_id": "WBGene00044455", "name": "SLC22A5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9BKR9", "map_id": "Q9BKR9", "name": "SLC22A5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9U539", "map_id": "Q9U539", "name": "oct-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003842", "map_id": "WBGene00003842", "name": "oct-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9UAW9", "map_id": "Q9UAW9", "name": "SLC22A5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A0K3AWD3", "map_id": "A0A0K3AWD3", "name": "SLC22A5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A238UKL7", "map_id": "A0A238UKL7", "name": "SLC22A5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EEI9", "map_id": "G5EEI9", "name": "SLC22A5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EGL6", "map_id": "G5EGL6", "name": "SLC22A5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O18247", "map_id": "O18247", "name": "SLC22A5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P46499", "map_id": "P46499", "name": "SLC22A5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q09617", "map_id": "Q09617", "name": "SLC22A5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q18613", "map_id": "Q18613", "name": "SLC22A5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q18655", "map_id": "Q18655", "name": "SLC22A5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q18795", "map_id": "Q18795", "name": "suex-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008271", "map_id": "WBGene00008271", "name": "suex-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q23501", "map_id": "Q23501", "name": "oct-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003843", "map_id": "WBGene00003843", "name": "oct-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10527406", "map_id": "G5EFQ5", "name": "rnt-1", "type": "inhibitor", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10527537", "map_id": "none", "name": "SLC22A18 exchanges extracellular organic cations for cytosolic H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_597604", "map_id": "none", "name": "SLC22A18 substrates", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_597623", "map_id": "none", "name": "SLC22A18 substrates", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10527534", "map_id": "Q18797", "name": "SLC22A18", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "WBGene00008273", "map_id": "WBGene00008273", "name": "SLC22A18", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10527458", "map_id": "none", "name": "OCT1 transports organic cations out of hepatic cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_549250", "map_id": "none", "name": "OCT1 substrates", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:6801", "map_id": "CHEBI:6801", "name": "CHEBI:6801", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_549282", "map_id": "CHEBI:16797", "name": "MNA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_6798162", "map_id": "CHEBI:15354", "name": "Cho", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "CHEBI:65133", "map_id": "CHEBI:65133", "name": "CHEBI:65133", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:15854", "map_id": "CHEBI:15854", "name": "CHEBI:15854", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_141324", "map_id": "CHEBI:16610", "name": "SPM", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_353560", "map_id": "CHEBI:15746", "name": "SPN", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_549264", "map_id": "none", "name": "OCT1 substrates", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10518788", "map_id": "Q19442", "name": "pes-23", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10527507", "map_id": "none", "name": "OCT3 mediates renal uptake of organic cations", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10527412", "map_id": "none", "name": "OCT2 mediates tubular uptake of organic cations in the kidney", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_549237", "map_id": "none", "name": "OCT2 substrates", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "CHEBI:31941", "map_id": "CHEBI:31941", "name": "CHEBI:31941", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:16737", "map_id": "CHEBI:16737", "name": "CHEBI:16737", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_351164", "map_id": "CHEBI:17431", "name": "AGM", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_549266", "map_id": "none", "name": "OCT2 substrates", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10527494", "map_id": "none", "name": "OCT2 mediates tubular secretion of organic cations in the kidney", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10527451", "map_id": "none", "name": "SLC22A4, 5,15,16 cotransport CAR, Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_164988", "map_id": "CHEBI:17126", "name": "CAR", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_30235", "map_id": "CHEBI:17126", "name": "CAR", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10527448", "map_id": "none", "name": "SLC22A4, 5,15,16", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10527343", "map_id": "none", "name": "OCT1 transports organic cations into hepatic cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10527505", "map_id": "none", "name": "OAT2 and OAT4 mediate transport of sulphate conjugates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_561071", "map_id": "none", "name": "OAT2/4 sulfate conjugate substrates", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_561062", "map_id": "none", "name": "OAT2/4 sulfate conjugate substrates", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_561075", "map_id": "CHEBI:16810", "name": "2OG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10527502", "map_id": "none", "name": "OAT2/4", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q10917", "map_id": "Q10917", "name": "SLC22A11", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020701", "map_id": "WBGene00020701", "name": "SLC22A11", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q22686", "map_id": "Q22686", "name": "SLC22A11", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10527492", "map_id": "none", "name": "OAT1-3 transport organic anions with antiport of dicarboxylic acids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_561049", "map_id": "none", "name": "OAT1-3 substrates", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "CHEBI:104011", "map_id": "CHEBI:104011", "name": "CHEBI:104011", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_561052", "map_id": "CHEBI:2453", "name": "ACV", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_561078", "map_id": "none", "name": "OAT1-3 substrates", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10527489", "map_id": "none", "name": "OAT1-3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10527516", "map_id": "none", "name": "SLC22A12 exchanges extracellular urate for cytosolic LACT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_429056", "map_id": "CHEBI:17775", "name": "urate", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_373863", "map_id": "CHEBI:422", "name": "LACT", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_30034", "map_id": "CHEBI:17775", "name": "urate", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10527513", "map_id": "none", "name": "Homologues of SLC22A12", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10523423", "map_id": "none", "name": "SLC5A7 cotransports Cho, Cl-, Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10523420", "map_id": "O02228", "name": "cho-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "WBGene00000501", "map_id": "WBGene00000501", "name": "cho-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10515237", "map_id": "none", "name": "Translocation of PLC-gamma1 to PIP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10515230", "map_id": "Q22070", "name": "phospho-plc-3", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10515235", "map_id": "none", "name": "Activated PLC gamma1 bound to PIP2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10515245", "map_id": "none", "name": "PLC-gamma1 hydrolyses PIP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10515242", "map_id": "Q22070", "name": "phospho-plc-3", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10529204", "map_id": "none", "name": "Acidification of Tf:TfR1 containing endosome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_74700", "compartment_display": "endosome membrane" }, { "id": "reaction_10529221", "map_id": "none", "name": "MCOLN1 transports Fe2+ from endosome lumen to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_74700", "compartment_display": "endosome membrane" }, { "id": "species_917810", "map_id": "CHEBI:29033", "name": "Fe2+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_171907", "compartment_display": "endosome lumen", "complex": "false" }, { "id": "species_10529218", "map_id": "Q8T666", "name": "cup-5", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "false" }, { "id": "WBGene00000846", "map_id": "WBGene00000846", "name": "cup-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10543223", "map_id": "none", "name": "Hemopexin binds Hemes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10543219", "map_id": "none", "name": "Homologues of HPX", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10543221", "map_id": "none", "name": "HPX:Hemes", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10503456", "map_id": "none", "name": "isobutyryl-CoA + FAD => methacrylyl-CoA + FADH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_70851", "map_id": "CHEBI:15479", "name": "ISB-CoA", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_70858", "map_id": "CHEBI:27754", "name": "MACR-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10503453", "map_id": "none", "name": "ACAD8 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q95YB2", "map_id": "Q95YB2", "name": "acdh-9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017874", "map_id": "WBGene00017874", "name": "acdh-9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10527201", "map_id": "none", "name": "a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_508187", "map_id": "none", "name": "KIC,KMVA,KIV", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:28654", "map_id": "CHEBI:28654", "name": "CHEBI:28654", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:17865", "map_id": "CHEBI:17865", "name": "CHEBI:17865", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:16530", "map_id": "CHEBI:16530", "name": "CHEBI:16530", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_508182", "map_id": "none", "name": "Leu, Ile, Val", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:57427", "map_id": "CHEBI:57427", "name": "CHEBI:57427", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:58045", "map_id": "CHEBI:58045", "name": "CHEBI:58045", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_29702", "map_id": "CHEBI:57762", "name": "L-Val", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10503361", "map_id": "none", "name": "BCAT1 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P54688", "map_id": "P54688", "name": "bcat-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001149", "map_id": "WBGene00001149", "name": "bcat-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10503426", "map_id": "none", "name": "alpha-methylbutyryl-CoA + FAD => tiglyl-CoA + FADH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_70718", "map_id": "CHEBI:15477", "name": "2MBUT-CoA", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_70799", "map_id": "CHEBI:15478", "name": "tiglyl-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10503423", "map_id": "none", "name": "ACADSB tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "O44549", "map_id": "O44549", "name": "acdh-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019433", "map_id": "WBGene00019433", "name": "acdh-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10527203", "map_id": "none", "name": "beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O <=> beta-methylcrotonyl-CoA + ATP + CO2 [MCCA]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_70772", "map_id": "CHEBI:15488", "name": "bMC-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_70744", "map_id": "CHEBI:15486", "name": "bMC-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_29896", "map_id": "CHEBI:17544", "name": "HCO3-", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10503403", "map_id": "none", "name": "6x(Btn-MCCC1:MCCC2)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "P34385", "map_id": "P34385", "name": "MCCC2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00303021", "map_id": "WBGene00303021", "name": "MCCC2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O45430", "map_id": "O45430", "name": "mccc-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009319", "map_id": "WBGene00009319", "name": "mccc-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10503492", "map_id": "none", "name": "methylmalonate semialdehyde + NAD+ + CoA => propionyl-CoA + CO2 + NADH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_30004", "map_id": "CHEBI:16256", "name": "2M3OPROA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_70843", "map_id": "CHEBI:15539", "name": "PROP-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10503489", "map_id": "P52713", "name": "alh-8", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "WBGene00000114", "map_id": "WBGene00000114", "name": "alh-8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10556964", "map_id": "none", "name": "PPM1K dephosphorylates p-BCKDH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10556954", "map_id": "none", "name": "p-BCKDH", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q23571", "map_id": "Q23571", "name": "dbt-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00014054", "map_id": "WBGene00014054", "name": "dbt-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q93619", "map_id": "Q93619", "name": "phospho-bckd-1b", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006518", "map_id": "WBGene00006518", "name": "phospho-bckd-1b", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O45924", "map_id": "O45924", "name": "bckd-1A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012713", "map_id": "WBGene00012713", "name": "bckd-1A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10503350", "map_id": "none", "name": "lipo-BCKDH", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "species_10556961", "map_id": "none", "name": "PPM1K:Mn2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "G5EEM6", "map_id": "G5EEM6", "name": "tap-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006524", "map_id": "WBGene00006524", "name": "tap-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10527205", "map_id": "none", "name": "alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_70836", "map_id": "CHEBI:15476", "name": "2MACA-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_70829", "map_id": "CHEBI:15449", "name": "aMbHBUT-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10503433", "map_id": "none", "name": "HSD17B10 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q19102", "map_id": "Q19102", "name": "ard-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000181", "map_id": "WBGene00000181", "name": "ard-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10527207", "map_id": "none", "name": "methylmalonyl semialdehyde + NADH + H+ <=> beta-hydroxyisobutyrate + NAD+", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_573404", "map_id": "CHEBI:11805", "name": "bHIBA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10503481", "map_id": "none", "name": "HIBADH tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q9XTI0", "map_id": "Q9XTI0", "name": "HIBADH", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007122", "map_id": "WBGene00007122", "name": "HIBADH", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10503466", "map_id": "none", "name": "ECHS1 hydrates methacrylyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_71847", "map_id": "CHEBI:28259", "name": "bHIB-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10503474", "map_id": "none", "name": "beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10503471", "map_id": "Q19278", "name": "hach-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "WBGene00017301", "map_id": "WBGene00017301", "name": "hach-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10503380", "map_id": "none", "name": "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_508190", "map_id": "none", "name": "Leu, Ile, Val", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "species_508181", "map_id": "none", "name": "KIC, KMVA, KIV", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "species_10503377", "map_id": "none", "name": "BCAT2 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q9XXD8", "map_id": "Q9XXD8", "name": "PXLP-BCAT2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012855", "map_id": "WBGene00012855", "name": "PXLP-BCAT2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10503446", "map_id": "none", "name": "alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10503443", "map_id": "none", "name": "ACAT1 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q22100", "map_id": "Q22100", "name": "kat-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002183", "map_id": "WBGene00002183", "name": "kat-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10503416", "map_id": "none", "name": "beta-methylglutaconyl-CoA + H2O <=> beta-hydroxy-beta-methylglutaryl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_70784", "map_id": "CHEBI:15467", "name": "bHMG-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10503413", "map_id": "none", "name": "AUH hexamer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "O45106", "map_id": "O45106", "name": "ech-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001154", "map_id": "WBGene00001154", "name": "ech-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10503353", "map_id": "none", "name": "BCKDH transfers CoA group from CoA-SH to BCAAs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_508261", "map_id": "none", "name": "BCAA-CoAs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "species_70715", "map_id": "CHEBI:15487", "name": "ISV-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10503390", "map_id": "none", "name": "isovaleryl-CoA + FAD => beta-methylcrotonyl-CoA + FADH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10503387", "map_id": "none", "name": "IVD tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "G5EEH6", "map_id": "G5EEH6", "name": "ivd-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00015326", "map_id": "WBGene00015326", "name": "ivd-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10557989", "map_id": "none", "name": "OTUB1,(OTUB2) binds TP53, UBE2D1, ESR1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10511537", "map_id": "none", "name": "Homologues of UBE2D1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10557985", "map_id": "none", "name": "OTUB1,(OTUB2)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9XVR6", "map_id": "Q9XVR6", "name": "otub-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007718", "map_id": "WBGene00007718", "name": "otub-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10557987", "map_id": "none", "name": "OTUB1,(OTUB2):UBE2D1,ESR1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10556681", "map_id": "none", "name": "OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10556669", "map_id": "none", "name": "OTUB1,(OTUB2)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10556677", "map_id": "none", "name": "RNF128,TRAF3,TRAF6,RHOA,TP53", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9XX98", "map_id": "Q9XX98", "name": "RNF130", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019185", "map_id": "WBGene00019185", "name": "RNF130", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O76671", "map_id": "O76671", "name": "RNF130", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10556679", "map_id": "none", "name": "OTUB1,(OTUB2):RNF128,TRAF3,TRAF6,RHOA,TP53", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10566184", "map_id": "none", "name": "OTUD7A hydrolyses K11diUb", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10566176", "map_id": "none", "name": "K11-Ub", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10566181", "map_id": "Q9N4T5", "name": "otub-2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00021733", "map_id": "WBGene00021733", "name": "otub-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10554672", "map_id": "none", "name": "ADRM1 binds 26S proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10554643", "map_id": "Q09289", "name": "rpn-13", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00016981", "map_id": "WBGene00016981", "name": "rpn-13", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10554645", "map_id": "none", "name": "ADRM1:26S proteasome", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q09289", "map_id": "Q09289", "name": "rpn-13", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10554649", "map_id": "none", "name": "ADRM1:26S proteaseome binds UCHL5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10554638", "map_id": "Q09444", "name": "ubh-4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00006724", "map_id": "WBGene00006724", "name": "ubh-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10554647", "map_id": "none", "name": "ADRM1:26S proteasome:UCHL5", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q09444", "map_id": "Q09444", "name": "ubh-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10556601", "map_id": "none", "name": "UCHL1, UCHL3 cleave ubiquitin adducts", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10556596", "map_id": "none", "name": "UCHL1,UCHL3:Ub-Lys", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q8MNY0", "map_id": "Q8MNY0", "name": "ubh-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006722", "map_id": "WBGene00006722", "name": "ubh-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q965V9", "map_id": "Q965V9", "name": "ubh-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006723", "map_id": "WBGene00006723", "name": "ubh-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_1131871", "map_id": "CHEBI:32551", "name": "L-lysine", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_459", "compartment_display": "cytoplasm", "complex": "false" }, { "id": "species_10556598", "map_id": "none", "name": "UCHL1,UCHL3:Ub", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10556653", "map_id": "none", "name": "UCHL3, SENP8 cleave NEDD8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10556644", "map_id": "none", "name": "UCHL3,SENP8:NEDD8(1-88)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q93725", "map_id": "Q93725", "name": "ned-8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003587", "map_id": "WBGene00003587", "name": "ned-8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86FN3", "map_id": "Q86FN3", "name": "ulp-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006738", "map_id": "WBGene00006738", "name": "ulp-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10556650", "map_id": "Q93725", "name": "ned-8", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10556648", "map_id": "none", "name": "UCHL3,SENP8:NEDD8", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10556465", "map_id": "none", "name": "USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10556179", "map_id": "none", "name": "USP7:PolyUb-TP53,PolyUb-MDM2,PolyUb-MDM4,PolyUb-FOXO4,PolyUb-PTEN", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "O16850", "map_id": "O16850", "name": "daf-16", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10556462", "map_id": "none", "name": "PolyUb", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10556185", "map_id": "none", "name": "USP7:TP53,MDM2,MDM4,FOXO4,PTEN", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10557760", "map_id": "none", "name": "USP49 deubiquitinates H2B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10557755", "map_id": "none", "name": "USP49:Ub-histone H2B", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9GRV2", "map_id": "Q9GRV2", "name": "usp-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013506", "map_id": "WBGene00013506", "name": "usp-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10557757", "map_id": "none", "name": "USP49:Histone H2B", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10557827", "map_id": "none", "name": "USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10557820", "map_id": "none", "name": "USP15:Ub-SMAD1,Ub-SMAD2,Ub-SMAD3,Ub-SMAD7:SMURF,Ub-KEAP1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q8WT44", "map_id": "Q8WT44", "name": "cyk-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000874", "map_id": "WBGene00000874", "name": "cyk-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "V6CJY2", "map_id": "V6CJY2", "name": "USP15", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019259", "map_id": "WBGene00019259", "name": "USP15", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10557824", "map_id": "none", "name": "USP15:SMAD1,SMAD2,SMAD3,KEAP1,SMAD7:SMURF2:TGFBR1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10556130", "map_id": "none", "name": "ADRM1:26S proteaseome binds USP14", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10556126", "map_id": "Q17361", "name": "usp-14", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00006856", "map_id": "WBGene00006856", "name": "usp-14", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10556128", "map_id": "none", "name": "ADRM1:26S proteasome:USP14", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q17361", "map_id": "Q17361", "name": "usp-14", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10557670", "map_id": "none", "name": "USP12, USP26 deubiquitinate AR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10557665", "map_id": "none", "name": "USP12:WDR48:WDR20,USP26:PolyUb-AR", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "P34547", "map_id": "P34547", "name": "usp-46", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011216", "map_id": "WBGene00011216", "name": "usp-46", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "D9N129", "map_id": "D9N129", "name": "wdr-20", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007428", "map_id": "WBGene00007428", "name": "wdr-20", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q20059", "map_id": "Q20059", "name": "wdr-48", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009441", "map_id": "WBGene00009441", "name": "wdr-48", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10557667", "map_id": "none", "name": "USP12:WDR48:WDR20,USP26:AR", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10557721", "map_id": "none", "name": "USP44 deubiquitinates CDC20", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10557716", "map_id": "none", "name": "USP44:PolyUb-CDC20", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10557718", "map_id": "none", "name": "USP44:CDC20", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10557836", "map_id": "none", "name": "USP19 binds HIF1A,BIRC2,BIRC3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10532174", "map_id": "G5EGD2", "name": "hif-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00001851", "map_id": "WBGene00001851", "name": "hif-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10557832", "map_id": "G5EBW2", "name": "usp-50", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00008441", "map_id": "WBGene00008441", "name": "usp-50", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10557834", "map_id": "none", "name": "USP19:HIF1A,BIRC2,BIRC3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "G5EBW2", "map_id": "G5EBW2", "name": "usp-50", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EGD2", "map_id": "G5EGD2", "name": "hif-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10557788", "map_id": "none", "name": "USP37:RUVLB1:PSMC5 deubiquitinates CCNA1,CCNA2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10557781", "map_id": "none", "name": "USP37:RUVLB1:PSMC5:PolyUb-CCNA1,PolyUb-CCNA2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "O17607", "map_id": "O17607", "name": "ruvb-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007784", "map_id": "WBGene00007784", "name": "ruvb-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34638", "map_id": "P34638", "name": "cya-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000863", "map_id": "WBGene00000863", "name": "cya-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q22319", "map_id": "Q22319", "name": "CCNA1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011591", "map_id": "WBGene00011591", "name": "CCNA1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9U2M5", "map_id": "Q9U2M5", "name": "cyd-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000870", "map_id": "WBGene00000870", "name": "cyd-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10557785", "map_id": "none", "name": "USP37:RUVLB1:PSMC5:CCNA1,CCNA2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10557678", "map_id": "none", "name": "CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10557675", "map_id": "none", "name": "CYLD:K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q7JMS4", "map_id": "Q7JMS4", "name": "cyld-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9NAC7", "map_id": "Q9NAC7", "name": "K63polyUb-RIPK1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013149", "map_id": "WBGene00013149", "name": "K63polyUb-RIPK1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10511040", "map_id": "Q9NAC7", "name": "RIPK1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10556096", "map_id": "none", "name": "ATXN3 binds VCP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10554396", "map_id": "none", "name": "VCP hexamer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10556072", "map_id": "O17850", "name": "atx-3", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00006446", "map_id": "WBGene00006446", "name": "atx-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10556094", "map_id": "none", "name": "ATXN3:VCP hexamer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "O17850", "map_id": "O17850", "name": "atx-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10556092", "map_id": "none", "name": "ATXN3 family cleave Ub chains", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10556089", "map_id": "none", "name": "ATXN3,ATXN3L,JOSD1,JOSD2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q8IAA2", "map_id": "Q8IAA2", "name": "josd-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022190", "map_id": "WBGene00022190", "name": "josd-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10556076", "map_id": "none", "name": "ATXN3 binds RAD23", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10556065", "map_id": "Q23451", "name": "rad-23", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00013924", "map_id": "WBGene00013924", "name": "rad-23", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10556074", "map_id": "none", "name": "ATXN3:RAD23", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q23451", "map_id": "Q23451", "name": "rad-23", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10520355", "map_id": "none", "name": "Formation of NR-NCOR Corepressor Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10519526", "map_id": "none", "name": "NR", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "G5EDJ0", "map_id": "G5EDJ0", "name": "fax-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001400", "map_id": "WBGene00001400", "name": "fax-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XVV3", "map_id": "Q9XVV3", "name": "nhr-67", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003657", "map_id": "WBGene00003657", "name": "nhr-67", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P41829", "map_id": "P41829", "name": "phospho-nhr-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q3V5L2", "map_id": "Q3V5L2", "name": "nhr-41", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022423", "map_id": "WBGene00022423", "name": "nhr-41", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5ED17", "map_id": "G5ED17", "name": "hpo-11", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010427", "map_id": "WBGene00010427", "name": "hpo-11", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q17771", "map_id": "Q17771", "name": "nhr-35", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003628", "map_id": "WBGene00003628", "name": "nhr-35", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10520353", "map_id": "none", "name": "NR-NCOR CoRepressor Complex ", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10564209", "map_id": "none", "name": "ARL1:GTP binds SCOC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10564205", "map_id": "A7LPF8", "name": "unc-69", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00006802", "map_id": "WBGene00006802", "name": "unc-69", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10564157", "map_id": "none", "name": "MyrG-ARL1:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q20758", "map_id": "Q20758", "name": "arl-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000187", "map_id": "WBGene00000187", "name": "arl-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10564207", "map_id": "none", "name": "SCOC:MyrG-ARL1:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "A7LPF8", "map_id": "A7LPF8", "name": "unc-69", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10564165", "map_id": "none", "name": "ARFRP1 recruits ARL1 to the TGN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane" }, { "id": "species_10564149", "map_id": "none", "name": "AcM-ARFRP1:GTP:SYS1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane", "complex": "true" }, { "id": "Q9N3C8", "map_id": "Q9N3C8", "name": "AcM-ARFRP1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021841", "map_id": "WBGene00021841", "name": "AcM-ARFRP1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8I7G0", "map_id": "Q8I7G0", "name": "SYS1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020193", "map_id": "WBGene00020193", "name": "SYS1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10564163", "map_id": "none", "name": "AcM-ARFRP1:GTP:SYS1:MyrG-ARL1:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane", "complex": "true" }, { "id": "reaction_10564037", "map_id": "none", "name": "RIC1:RGP1 stimulates nucleotide RAB6 nucleotide exchange", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane" }, { "id": "species_10564028", "map_id": "none", "name": "RAB6:GDP:RIC1:RGP1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane", "complex": "true" }, { "id": "Q7YWW8", "map_id": "Q7YWW8", "name": "RGP1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010815", "map_id": "WBGene00010815", "name": "RGP1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q09417", "map_id": "Q09417", "name": "RIC1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011071", "map_id": "WBGene00011071", "name": "RIC1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10564034", "map_id": "none", "name": "RAB6:GTP:RIC1:RGP1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane", "complex": "true" }, { "id": "reaction_10564519", "map_id": "none", "name": "RAB43 hydrolyses GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane" }, { "id": "species_10564512", "map_id": "none", "name": "RAB43:GTP:USP6NL", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane", "complex": "true" }, { "id": "Q9U2D8", "map_id": "Q9U2D8", "name": "tbc-17", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012894", "map_id": "WBGene00012894", "name": "tbc-17", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9U1W9", "map_id": "Q9U1W9", "name": "rab-19", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004278", "map_id": "WBGene00004278", "name": "rab-19", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10564516", "map_id": "none", "name": "RAB43:GDP:USP6NL", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane", "complex": "true" }, { "id": "reaction_10564422", "map_id": "none", "name": "SNAPs and NSF hexamer bind cis-SNARE at the TGN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane" }, { "id": "species_10564418", "map_id": "none", "name": "STX10:STX16:VTI1A:VAMP3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane", "complex": "true" }, { "id": "Q9TY08", "map_id": "Q9TY08", "name": "syx-16", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022534", "map_id": "WBGene00022534", "name": "syx-16", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O18230", "map_id": "O18230", "name": "vti-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013302", "map_id": "WBGene00013302", "name": "vti-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10564420", "map_id": "none", "name": "STX10:STX16:VTI1A:VAMP3:NSF hexamer:SNAPs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane", "complex": "true" }, { "id": "reaction_10564200", "map_id": "none", "name": "ARL1:GTP binds ARFIP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10564196", "map_id": "P34445", "name": "ARFIP2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00010040", "map_id": "WBGene00010040", "name": "ARFIP2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10564198", "map_id": "none", "name": "ARFIP2:MyrG-ARL1:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P34445", "map_id": "P34445", "name": "ARFIP2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10564171", "map_id": "none", "name": "SYS1 binds AcM-ARFRP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane" }, { "id": "species_10564139", "map_id": "Q8I7G0", "name": "SYS1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane", "complex": "false" }, { "id": "species_10564169", "map_id": "none", "name": "AcM-ARFRP1:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10564523", "map_id": "none", "name": "RAB43:GTP binds USP8NL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane" }, { "id": "species_10564510", "map_id": "none", "name": "RAB43:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane", "complex": "true" }, { "id": "species_10564521", "map_id": "Q9U2D8", "name": "tbc-17", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10564191", "map_id": "none", "name": "ARL1 recruits TGN Golgin homodimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane" }, { "id": "species_10564187", "map_id": "none", "name": "TGN Golgin dimers", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "A0A3P6PCP8", "map_id": "A0A3P6PCP8", "name": "golg-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010306", "map_id": "WBGene00010306", "name": "golg-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q18013", "map_id": "Q18013", "name": "gcc-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002220", "map_id": "WBGene00002220", "name": "gcc-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10564189", "map_id": "none", "name": "AcG-ARFRP1:GTP:SYS1:MyrG-ARL1:GTP:TGN Golgin dimers", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane", "complex": "true" }, { "id": "reaction_10564030", "map_id": "none", "name": "RIC1:RGP1 recruits RAB6:GDP to the TGN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane" }, { "id": "species_10563998", "map_id": "none", "name": "RAB6:GDP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10564010", "map_id": "none", "name": "RIC1:RGP1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane", "complex": "true" }, { "id": "reaction_10546544", "map_id": "none", "name": "Phosphorylated ERF translocates to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10546532", "map_id": "none", "name": "Homologues of p-T526-ERF", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "A0A4V0IJZ6", "map_id": "A0A4V0IJZ6", "name": "phospho-p-T526-ERF", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00304788", "map_id": "WBGene00304788", "name": "phospho-p-T526-ERF", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O44138", "map_id": "O44138", "name": "phospho-ets-8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016798", "map_id": "WBGene00016798", "name": "phospho-ets-8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A4V0IK77", "map_id": "A0A4V0IK77", "name": "phospho-ets-9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016865", "map_id": "WBGene00016865", "name": "phospho-ets-9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EDL0", "map_id": "G5EDL0", "name": "phospho-lin-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002990", "map_id": "WBGene00002990", "name": "phospho-lin-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10546542", "map_id": "none", "name": "Homologues of p-T526-ERF", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10508244", "map_id": "none", "name": "3-Oxohexanoyl-CoA+CoA-SH<=>Butanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_77320", "map_id": "CHEBI:27648", "name": "3-Oxohexanoyl-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_77318", "map_id": "CHEBI:15517", "name": "BT-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10508246", "map_id": "none", "name": "(S)-Hydroxyhexanoyl-CoA+NAD<=>3-Oxohexanoyl-CoA+NADH+H", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_77322", "map_id": "CHEBI:28276", "name": "(S)-Hydroxyhexanoyl-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10508248", "map_id": "none", "name": "trans-Hex-2-enoyl-CoA+H2O<=>(S)-Hydroxyhexanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_77324", "map_id": "CHEBI:28706", "name": "trans-Hex-2-enoyl-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10557962", "map_id": "none", "name": "Ligation of newly synthesized repair patch to incised DNA in TC-NER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10557947", "map_id": "none", "name": "TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "P34409", "map_id": "P34409", "name": "polk-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017696", "map_id": "WBGene00017696", "name": "polk-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q18963", "map_id": "Q18963", "name": "csa-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008403", "map_id": "WBGene00008403", "name": "csa-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q21554", "map_id": "Q21554", "name": "ddb-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010890", "map_id": "WBGene00010890", "name": "ddb-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q17392", "map_id": "Q17392", "name": "cul-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000839", "map_id": "WBGene00000839", "name": "cul-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q23088", "map_id": "Q23088", "name": "uvs-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022812", "map_id": "WBGene00022812", "name": "uvs-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86D18", "map_id": "Q86D18", "name": "ERCC6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010011", "map_id": "WBGene00010011", "name": "ERCC6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q22139", "map_id": "Q22139", "name": "sel-13", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011411", "map_id": "WBGene00011411", "name": "sel-13", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10557960", "map_id": "none", "name": "TC-NER post-incision complex:dsDNA with transcription bubble", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10556705", "map_id": "none", "name": "(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10557950", "map_id": "none", "name": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10557945", "map_id": "none", "name": "TC-NER post-incision complex:incised DNA without lesion:trimmed nascent mRNA:PCNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10517125", "map_id": "none", "name": "DNMT1,3A,3B:PRC2 methylates cytosine and histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10517106", "map_id": "none", "name": "DNMT1,3A,3B:PRC2:Chromatin", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10517122", "map_id": "none", "name": "DNMT1,3A,3B:PRC2:Chromatin (5-mC, H3K27me3)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10568425", "map_id": "none", "name": "CDK6 binds RUNX1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10568421", "map_id": "none", "name": "RUNX1,RUNX1:CBFB", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10568419", "map_id": "Q9XTR1", "name": "cdk-4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00000406", "map_id": "WBGene00000406", "name": "cdk-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10568423", "map_id": "none", "name": "RUNX1,RUNX1:CBFB:CDK6", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9XTR1", "map_id": "Q9XTR1", "name": "cdk-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10566203", "map_id": "none", "name": "CBFB binds RUNX1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10566199", "map_id": "G5EFQ5", "name": "rnt-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10566197", "map_id": "Q95ZL9", "name": "bro-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10568429", "map_id": "none", "name": "PML binds RUNX1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10568427", "map_id": "none", "name": "RUNX1:PML", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10567459", "map_id": "none", "name": "SLC5A12 cotransports Na+ with LACT, PYR, NCA from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_8876310", "map_id": "none", "name": "LACT, PYR, NCA", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_8869604", "map_id": "CHEBI:32544", "name": "NCA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_8876304", "map_id": "none", "name": "LACT, PYR, NCA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_197230", "map_id": "CHEBI:15940", "name": "NCA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10567456", "map_id": "O17394", "name": "SLC5A12", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "WBGene00018716", "map_id": "WBGene00018716", "name": "SLC5A5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10553973", "map_id": "none", "name": "SLC26A4 transports I- from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_209785", "map_id": "CHEBI:16382", "name": "I-", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_209818", "map_id": "CHEBI:16382", "name": "I-", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10553970", "map_id": "none", "name": "Homologues of SLC26A4", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10522983", "map_id": "none", "name": "SLC26A3,6 exchange Cl- for HCO3-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10522980", "map_id": "none", "name": "SLC26A3,6", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10522894", "map_id": "none", "name": "Group 3 - Selective Cl- transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10522891", "map_id": "none", "name": "SLC26 chloride transporters", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "G5EDS5", "map_id": "G5EDS5", "name": "sulp-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017464", "map_id": "WBGene00017464", "name": "sulp-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10521777", "map_id": "none", "name": "ATP2B1-4 transport cytosolic Ca2+ to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10521774", "map_id": "none", "name": "ATP2B1-4", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q95XP5", "map_id": "Q95XP5", "name": "mca-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003153", "map_id": "WBGene00003153", "name": "mca-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9TYP9", "map_id": "Q9TYP9", "name": "mca-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019875", "map_id": "WBGene00019875", "name": "mca-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EFR6", "map_id": "G5EFR6", "name": "mca-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003151", "map_id": "WBGene00003151", "name": "mca-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10522476", "map_id": "none", "name": "SLC8A1,2,3 exchange 3Na+ for Ca2+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10522473", "map_id": "none", "name": "SLC8A1,2,3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "G5EF08", "map_id": "G5EF08", "name": "ncx-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003566", "map_id": "WBGene00003566", "name": "ncx-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "H2KYP2", "map_id": "H2KYP2", "name": "ncx-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003567", "map_id": "WBGene00003567", "name": "ncx-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10504094", "map_id": "none", "name": "Homologues of CALM1", "type": "inhibitor", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10521789", "map_id": "none", "name": "ATP2A1-3 transport cytosolic Ca2+ to dense tubular network lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_114521", "compartment_display": "platelet dense tubular network membrane" }, { "id": "species_427899", "map_id": "CHEBI:15378", "name": "H+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_114580", "compartment_display": "platelet dense tubular network lumen", "complex": "false" }, { "id": "species_10521782", "map_id": "G5EEK8", "name": "sca-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_114521", "compartment_display": "platelet dense tubular network membrane", "complex": "false" }, { "id": "WBGene00004736", "map_id": "WBGene00004736", "name": "sca-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10521026", "map_id": "none", "name": "Gi activation by P2Y purinoceptor 12", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10521021", "map_id": "none", "name": "ADP:P2RY12:G-protein Gi (inactive)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10521023", "map_id": "none", "name": "ADP:P2RY12:G-protein Gi (active)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10516882", "map_id": "none", "name": "Phosphorylated FOXO1A is excluded from the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10516880", "map_id": "O16850", "name": "phospho-daf-16", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10516878", "map_id": "none", "name": "AKT phosphorylates FOXO1A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10544176", "map_id": "none", "name": "Sec is reduced to H2Se by PXLP-K259-SCLY dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5359016", "map_id": "none", "name": "reduced acceptor", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_5357697", "map_id": "CHEBI:16633", "name": "Sec", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_5357660", "map_id": "CHEBI:16503", "name": "H2Se", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_5359011", "map_id": "none", "name": "acceptor", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10544173", "map_id": "none", "name": "PXLP-K259-SCLY dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q19434", "map_id": "Q19434", "name": "PXLP-K259-SCLY", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017442", "map_id": "WBGene00017442", "name": "PXLP-K259-SCLY", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10557618", "map_id": "none", "name": "PXLP-K278-ETNPPL tetramer hydrolyses PETA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_5696414", "map_id": "CHEBI:17553", "name": "PETA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_113532", "map_id": "CHEBI:15343", "name": "CH3CHO", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10557615", "map_id": "none", "name": "PXLP-K278-ETNPPL tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "reaction_10535129", "map_id": "none", "name": "PA is dephosphorylated to DAG by LPIN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_426755", "map_id": "CHEBI:16337", "name": "PA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_1500596", "map_id": "CHEBI:17815", "name": "DAG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10535126", "map_id": "none", "name": "LPIN", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q9XXT5", "map_id": "Q9XXT5", "name": "lpin-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10535146", "map_id": "none", "name": "ETA is phosphorylated to PETA by CHK/ETNK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1498751", "map_id": "CHEBI:16000", "name": "ETA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_428686", "map_id": "CHEBI:17553", "name": "PETA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10535028", "map_id": "none", "name": "CHK dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P46560", "map_id": "P46560", "name": "ckb-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000513", "map_id": "WBGene00000513", "name": "ckb-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O17610", "map_id": "O17610", "name": "cka-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000509", "map_id": "WBGene00000509", "name": "cka-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q22820", "map_id": "Q22820", "name": "ckc-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000515", "map_id": "WBGene00000515", "name": "ckc-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P46558", "map_id": "P46558", "name": "ckb-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000511", "map_id": "WBGene00000511", "name": "ckb-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q22942", "map_id": "Q22942", "name": "cka-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000510", "map_id": "WBGene00000510", "name": "cka-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P46559", "map_id": "P46559", "name": "ckb-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000512", "map_id": "WBGene00000512", "name": "ckb-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9GZF3", "map_id": "Q9GZF3", "name": "ckb-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000514", "map_id": "WBGene00000514", "name": "ckb-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10535118", "map_id": "none", "name": "PETA and CTP are condensed to CDP-ETA by PCY2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_1500603", "map_id": "CHEBI:16732", "name": "CDP-ETA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10535115", "map_id": "none", "name": "PCYT2 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "X5LPX5", "map_id": "X5LPX5", "name": "pcyt-2.1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021352", "map_id": "WBGene00021352", "name": "pcyt-2.1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10534959", "map_id": "none", "name": "CDP-ETA and DAG are converted to PE by CEPT1/EPT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_1500581", "map_id": "CHEBI:16038", "name": "PE", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10534956", "map_id": "none", "name": "CEPT1/EPT1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "G5EC09", "map_id": "G5EC09", "name": "cept-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009057", "map_id": "WBGene00009057", "name": "cept-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EC25", "map_id": "G5EC25", "name": "cept-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013024", "map_id": "WBGene00013024", "name": "cept-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O44732", "map_id": "O44732", "name": "ept-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018797", "map_id": "WBGene00018797", "name": "ept-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10557283", "map_id": "none", "name": "SEC4C,D bind GOSR2 and STX5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10515692", "map_id": "Q19371", "name": "sec-24.1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00004755", "map_id": "WBGene00004755", "name": "sec-24.1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10515690", "map_id": "none", "name": "GOSR2,STX5", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "species_10515696", "map_id": "Q9U2Z1", "name": "sec-23", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00004754", "map_id": "WBGene00004754", "name": "sec-23", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10515698", "map_id": "none", "name": "SEC23A:SEC24C,D:GOSR2,STX5", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q9U2Z1", "map_id": "Q9U2Z1", "name": "sec-23", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q19371", "map_id": "Q19371", "name": "sec-24.1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10557378", "map_id": "none", "name": "LMAN family proteins bind glycosylated cargo", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10515814", "map_id": "none", "name": "glycosylated LMAN cargo", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "species_10515745", "map_id": "none", "name": "LMAN family receptors", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "G5EDE8", "map_id": "G5EDE8", "name": "ile-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002070", "map_id": "WBGene00002070", "name": "ile-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10515816", "map_id": "none", "name": "LMAN receptor:glycosylated cargo", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10557287", "map_id": "none", "name": "SEC24A,B:SEC23A bind SEC22B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10515950", "map_id": "Q23368", "name": "sec-24.2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00004756", "map_id": "WBGene00004756", "name": "sec-24.2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10557285", "map_id": "none", "name": "SEC24A,B:SEC23A:SEC22B", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q23368", "map_id": "Q23368", "name": "sec-24.2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10557501", "map_id": "none", "name": "Inner coat assembly and cargo binding", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10515678", "map_id": "none", "name": "SAR1B:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q23445", "map_id": "Q23445", "name": "sar-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022678", "map_id": "WBGene00022678", "name": "sar-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10515818", "map_id": "none", "name": "COPII cargo:receptors", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q22361", "map_id": "Q22361", "name": "cni-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011648", "map_id": "WBGene00011648", "name": "cni-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10515956", "map_id": "none", "name": "SEC23:SEC24", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10515820", "map_id": "none", "name": "COPII cargo receptors:SAR1B:GTP:SEC23:SEC24", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10557388", "map_id": "none", "name": "CNIH2,3 bind GRIA1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10515725", "map_id": "none", "name": "Homologues of GRIA1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "species_10515703", "map_id": "Q22361", "name": "cni-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10515727", "map_id": "none", "name": "CNIH2,3:GRIA1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10557504", "map_id": "none", "name": "Loss of SAR1B GTPase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10515940", "map_id": "none", "name": "SAR1B:GDP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10557376", "map_id": "none", "name": "NSF ATPase activity dissociates cis-SNARE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_6791047", "compartment_display": "endoplasmic reticulum-Golgi intermediate compartment membrane" }, { "id": "species_10557371", "map_id": "none", "name": "cis-SNARE:NSF hexamer:3xSNAP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_6791047", "compartment_display": "endoplasmic reticulum-Golgi intermediate compartment membrane", "complex": "true" }, { "id": "Q20364", "map_id": "Q20364", "name": "sly-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009654", "map_id": "WBGene00009654", "name": "sly-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10557359", "map_id": "Q20797", "name": "syx-5", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_6791047", "compartment_display": "endoplasmic reticulum-Golgi intermediate compartment membrane", "complex": "false" }, { "id": "species_10557357", "map_id": "Q20364", "name": "sly-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10557352", "map_id": "P41941", "name": "memb-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_6791047", "compartment_display": "endoplasmic reticulum-Golgi intermediate compartment membrane", "complex": "false" }, { "id": "species_10557350", "map_id": "G5EEU1", "name": "nbet-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_6791047", "compartment_display": "endoplasmic reticulum-Golgi intermediate compartment membrane", "complex": "false" }, { "id": "species_10557367", "map_id": "none", "name": "ER-to-ERGIC v-SNARES", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_6791047", "compartment_display": "endoplasmic reticulum-Golgi intermediate compartment membrane", "complex": "true" }, { "id": "reaction_10515938", "map_id": "none", "name": "Vesicle budding", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13959", "compartment_display": "COPII-coated ER to Golgi transport vesicle" }, { "id": "species_10515831", "map_id": "none", "name": "COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer:SEC13:SEC31:SEC23IP:v-SNARES", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "G5EFY6", "map_id": "G5EFY6", "name": "sec-31", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011338", "map_id": "WBGene00011338", "name": "sec-31", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "H2KZQ8", "map_id": "H2KZQ8", "name": "sec-16a.2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017419", "map_id": "WBGene00017419", "name": "sec-16a.2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34643", "map_id": "P34643", "name": "sec-16A.1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013985", "map_id": "WBGene00013985", "name": "sec-16A.1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9U1W1", "map_id": "Q9U1W1", "name": "tfg-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006565", "map_id": "WBGene00006565", "name": "tfg-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10515935", "map_id": "Q23445", "name": "sar-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10515933", "map_id": "none", "name": "COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_13945", "compartment_display": "ER to Golgi transport vesicle membrane", "complex": "true" }, { "id": "species_10515827", "map_id": "none", "name": "TFG hexamer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10515648", "map_id": "none", "name": "SEC16A:SEC16B", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10557380", "map_id": "none", "name": "COPII coat binds TRAPPCII and RAB1:GDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13959", "compartment_display": "COPII-coated ER to Golgi transport vesicle" }, { "id": "species_10557263", "map_id": "none", "name": "TRAPPCII", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9NA81", "map_id": "Q9NA81", "name": "trpp-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013259", "map_id": "WBGene00013259", "name": "trpp-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G4SNB8", "map_id": "G4SNB8", "name": "TRAPPC2L", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00044604", "map_id": "WBGene00044604", "name": "TRAPPC2L", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34605", "map_id": "P34605", "name": "trpp-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00014222", "map_id": "WBGene00014222", "name": "trpp-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q93330", "map_id": "Q93330", "name": "trpp-9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007956", "map_id": "WBGene00007956", "name": "trpp-9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "B1V899", "map_id": "B1V899", "name": "trpp-10", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022138", "map_id": "WBGene00022138", "name": "trpp-10", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XU81", "map_id": "Q9XU81", "name": "trpp-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010699", "map_id": "WBGene00010699", "name": "trpp-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O02173", "map_id": "O02173", "name": "sedl-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021046", "map_id": "WBGene00021046", "name": "sedl-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q20100", "map_id": "Q20100", "name": "trpp-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018088", "map_id": "WBGene00018088", "name": "trpp-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10557265", "map_id": "none", "name": "COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GDP", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_13959", "compartment_display": "COPII-coated ER to Golgi transport vesicle", "complex": "true" }, { "id": "reaction_10557289", "map_id": "none", "name": "SEC16 complex binds SAR1B:GTP:SEC23:SEC24", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10515829", "map_id": "none", "name": "COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10515948", "map_id": "none", "name": "SAR1 Activation And Membrane Binding", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10515945", "map_id": "Q21115", "name": "sec-12", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "WBGene00010496", "map_id": "WBGene00010496", "name": "sec-12", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10564493", "map_id": "none", "name": "TBC1D20 binds RAB1:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_6791047", "compartment_display": "endoplasmic reticulum-Golgi intermediate compartment membrane" }, { "id": "species_10564489", "map_id": "Q9XWI2", "name": "tbc-20", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_6791047", "compartment_display": "endoplasmic reticulum-Golgi intermediate compartment membrane", "complex": "false" }, { "id": "WBGene00013196", "map_id": "WBGene00013196", "name": "tbc-20", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10564491", "map_id": "none", "name": "RAB1:GTP:TBC1D20", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_6791047", "compartment_display": "endoplasmic reticulum-Golgi intermediate compartment membrane", "complex": "true" }, { "id": "Q9XWI2", "map_id": "Q9XWI2", "name": "tbc-20", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10564496", "map_id": "none", "name": "TBC1D20 stimulates GTPase activity of RAB1, resulting in hydrolysis of GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_6791047", "compartment_display": "endoplasmic reticulum-Golgi intermediate compartment membrane" }, { "id": "reaction_10557460", "map_id": "none", "name": "BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_6791047", "compartment_display": "endoplasmic reticulum-Golgi intermediate compartment membrane" }, { "id": "species_10557386", "map_id": "none", "name": "COPII cargo:receptors:v:SNAREs:GOLGA2:GORASP1:USO1 homodimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_6791047", "compartment_display": "endoplasmic reticulum-Golgi intermediate compartment membrane", "complex": "true" }, { "id": "species_10557361", "map_id": "none", "name": "BET1:GOSR2:STX5:SCFD1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_6791047", "compartment_display": "endoplasmic reticulum-Golgi intermediate compartment membrane", "complex": "true" }, { "id": "species_10557295", "map_id": "none", "name": "GOLGA2:GORASP1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_6791047", "compartment_display": "endoplasmic reticulum-Golgi intermediate compartment membrane", "complex": "true" }, { "id": "species_10557369", "map_id": "none", "name": "cis-SNARE", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_6791047", "compartment_display": "endoplasmic reticulum-Golgi intermediate compartment membrane", "complex": "true" }, { "id": "species_10557458", "map_id": "none", "name": "COPII cargo:receptors", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_6791047", "compartment_display": "endoplasmic reticulum-Golgi intermediate compartment membrane", "complex": "true" }, { "id": "reaction_10557272", "map_id": "none", "name": "Nucleotide exchange on RAB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13959", "compartment_display": "COPII-coated ER to Golgi transport vesicle" }, { "id": "species_10557269", "map_id": "none", "name": "COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_13959", "compartment_display": "COPII-coated ER to Golgi transport vesicle", "complex": "true" }, { "id": "reaction_10557373", "map_id": "none", "name": "NSF and SNAPs bind cis-SNARE complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_6791047", "compartment_display": "endoplasmic reticulum-Golgi intermediate compartment membrane" }, { "id": "reaction_10557310", "map_id": "none", "name": "RAB1:GTP binds USO1 and GORASP1:GOLGA2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10557308", "map_id": "none", "name": "COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP:USO1 homodimer:GOLGA2:GORASP1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_6791047", "compartment_display": "endoplasmic reticulum-Golgi intermediate compartment membrane", "complex": "true" }, { "id": "reaction_10521505", "map_id": "none", "name": "Alpha-2A,alpha-2C Adrenergic Receptors bind adrenaline or noradrenaline", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10521511", "map_id": "none", "name": "Alpha-2A,alpha-2C Adrenergic Receptors activate Gi.Go heterotrimeric G proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10521509", "map_id": "none", "name": "G-alpha(i,o):GDP:G beta:G gamma", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10521501", "map_id": "none", "name": "G-alpha(i,o):GTP:G-beta:G-gamma", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10521518", "map_id": "none", "name": "G-beta:G-gamma inhibits Adenylate cyclase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10521499", "map_id": "none", "name": "G-beta:G-gamma (candidates)", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10521514", "map_id": "none", "name": "Adenylate Cyclase V or VI", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10521516", "map_id": "none", "name": "Adenylate cyclase type V or VI: G-protein beta gamma Complex", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10521503", "map_id": "none", "name": "Gi,Go Heterotrimeric G-protein complex dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10521493", "map_id": "none", "name": "G-alpha(i,o):GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10571830", "map_id": "none", "name": "FUT2 transfers Fuc to Type 1 chains to form H antigen-sec", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "species_9036984", "map_id": "CHEBI:140162", "name": "Type 1 chain", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_9037036", "map_id": "CHEBI:140180", "name": "H antigen-sec", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10571827", "map_id": "O61739", "name": "FUT2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "WBGene00015019", "map_id": "WBGene00015019", "name": "FUT2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10571804", "map_id": "none", "name": "FUT1 transfers Fuc to Type 2 chains to form H antigen-RBC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "species_9033790", "map_id": "CHEBI:139350", "name": "Type 2 chain", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_9033793", "map_id": "CHEBI:139351", "name": "H antigen-RBC", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10571801", "map_id": "O61739", "name": "FUT1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "reaction_10563778", "map_id": "none", "name": "RNA polymerase II binds initiation factors at promoter of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10504431", "map_id": "none", "name": "RNA Polymerase II holoenzyme complex (unphosphorylated)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10563743", "map_id": "none", "name": "Initiation factors:CDK7:snRNA gene", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "P91868", "map_id": "P91868", "name": "snpc-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001568", "map_id": "WBGene00001568", "name": "snpc-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q17694", "map_id": "Q17694", "name": "snpc-1.1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00015513", "map_id": "WBGene00015513", "name": "snpc-1.1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7YTH5", "map_id": "Q7YTH5", "name": "taf-8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006390", "map_id": "WBGene00006390", "name": "taf-8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10563741", "map_id": "none", "name": "RNA polymerase II (unphosphorylated):Initiation factors at promoter of snRNA gene", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10564498", "map_id": "none", "name": "CBCAP complex binds 7-methylguanosine cap of snRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10504700", "map_id": "Q966L5", "name": "SRRT", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10564404", "map_id": "none", "name": "RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:capped pre-snRNA:Initiation factors:snRNA gene", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "A5Z2V1", "map_id": "A5Z2V1", "name": "cids-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009451", "map_id": "WBGene00009451", "name": "cids-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34281", "map_id": "P34281", "name": "cids-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00015347", "map_id": "WBGene00015347", "name": "cids-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q22805", "map_id": "Q22805", "name": "ZC3H8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020827", "map_id": "WBGene00020827", "name": "ZC3H8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9U3K2", "map_id": "Q9U3K2", "name": "ints-11", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008642", "map_id": "WBGene00008642", "name": "ints-11", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "B7WN63", "map_id": "B7WN63", "name": "ints-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000994", "map_id": "WBGene00000994", "name": "ints-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O01483", "map_id": "O01483", "name": "ints-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00015499", "map_id": "WBGene00015499", "name": "ints-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EDW9", "map_id": "G5EDW9", "name": "ints-7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008361", "map_id": "WBGene00008361", "name": "ints-7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "H2KML7", "map_id": "H2KML7", "name": "ints-8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013021", "map_id": "WBGene00013021", "name": "ints-8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "E5QCH1", "map_id": "E5QCH1", "name": "ints-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013877", "map_id": "WBGene00013877", "name": "ints-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q95ZM2", "map_id": "Q95ZM2", "name": "ints-9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017608", "map_id": "WBGene00017608", "name": "ints-9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "W6RQY9", "map_id": "W6RQY9", "name": "ints-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022360", "map_id": "WBGene00022360", "name": "ints-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O18167", "map_id": "O18167", "name": "ints-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012234", "map_id": "WBGene00012234", "name": "ints-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q17749", "map_id": "Q17749", "name": "NABP2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00015554", "map_id": "WBGene00015554", "name": "NABP2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O44500", "map_id": "O44500", "name": "ints-13", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019822", "map_id": "WBGene00019822", "name": "ints-13", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9U267", "map_id": "Q9U267", "name": "ints-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013075", "map_id": "WBGene00013075", "name": "ints-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P30641", "map_id": "P30641", "name": "rpap-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011143", "map_id": "WBGene00011143", "name": "rpap-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10513169", "map_id": "Q9N4E8", "name": "PHAX", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00022192", "map_id": "WBGene00022192", "name": "PHAX", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10564380", "map_id": "none", "name": "RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9N4E8", "map_id": "Q9N4E8", "name": "PHAX", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10564407", "map_id": "none", "name": "Pre-snRNA is elongated and capped with 7-methylguanosine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_29470", "map_id": "CHEBI:17677", "name": "CTP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_113562", "map_id": "CHEBI:15713", "name": "UTP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10564402", "map_id": "none", "name": "RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10563753", "map_id": "none", "name": "CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10563750", "map_id": "none", "name": "RNA polymerase II (phosphoserine-5,7):Initiation factors:CDK7:snRNA gene", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10564396", "map_id": "none", "name": "Integrator complex processes the 3' end of snRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10564382", "map_id": "none", "name": "RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:Initiation factors:snRNA gene", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10564388", "map_id": "none", "name": "CBCAP:capped snRNA U1,U2,U4,U4atac,U5,U11,U12", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10505223", "map_id": "Q09345", "name": "pcf-11", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10564394", "map_id": "Q22453", "name": "ssup-72", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00020480", "map_id": "WBGene00020480", "name": "ssup-72", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10548576", "map_id": "none", "name": "EPH:EFN tetramers oligomerise", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10548574", "map_id": "none", "name": "EPHAs:EFNAs,EPHBs:EFNBs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10548572", "map_id": "none", "name": "EPH-EFN dimers", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10548507", "map_id": "none", "name": "EPH-ephrin oligomers", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10548786", "map_id": "none", "name": "EPHAs bind EFNAs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10548447", "map_id": "O61460", "name": "vab-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10548442", "map_id": "none", "name": "EFNAs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10548465", "map_id": "none", "name": "EPHAs:EFNAs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10549059", "map_id": "none", "name": "SDC2 multimerises", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10549032", "map_id": "P50605", "name": "phospho-sdn-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10549057", "map_id": "none", "name": "p-Y179,Y191-SDC2 cluster", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10548585", "map_id": "none", "name": "p190RhoGEF exchanges GTP for GDP on RHOA, activating it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10548582", "map_id": "none", "name": "EFNBs:p-EPHBs:p-Y397-PTK2:ARHGEF28", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10548714", "map_id": "none", "name": "PAK1 autophosphorylates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10548701", "map_id": "none", "name": "RAC1:GTP:PAK1 dimer:RAC1:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10548711", "map_id": "none", "name": "RAC1-GTP:p-S144,T423-PAK1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10549035", "map_id": "none", "name": "p-EPHB phosphorylates SDC2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10537380", "map_id": "P50605", "name": "sdn-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10548561", "map_id": "none", "name": "p-EPHB:EFNB oligomers", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10549038", "map_id": "none", "name": "p-TIAM1 exchanges GTP for GDP on RAC1, activating it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10548757", "map_id": "none", "name": "EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly:p-Y829-TIAM1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10548784", "map_id": "none", "name": "EPHB:NMDAR binds TIAM1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10548750", "map_id": "none", "name": "EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10548752", "map_id": "none", "name": "EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly:TIAM1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10548599", "map_id": "none", "name": "N-WASP binds ARP2/3 and G-actin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10537823", "map_id": "none", "name": "ARP2/3 complex (ATP bound)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10548595", "map_id": "none", "name": "p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP:PI(4,5)P2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10548597", "map_id": "none", "name": "p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP:PI(4,5)P2:ARP2/3;G-actin", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10548760", "map_id": "none", "name": "EPHB phosphorylates TIAM1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10548378", "map_id": "none", "name": "RHOA:GTP binds ROCK, activating it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10548603", "map_id": "none", "name": "Recruitment of p190RhoGEF to p-FAK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10548580", "map_id": "none", "name": "EFNBs:p-EPHBs:p-Y397-PTK2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10548578", "map_id": "A0A0K3AQN0", "name": "ARHGEF28", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10548605", "map_id": "none", "name": "CDC42 and PIP2 bind WASL, activating it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10548593", "map_id": "none", "name": "p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10548703", "map_id": "none", "name": "PAK1 binds RAC1:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10549055", "map_id": "none", "name": "p120-RasGAP activates GTP hydrolysis on RAS, inactivating it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10549048", "map_id": "none", "name": "p-EPHBs:EFNBs:RASA1:HRAS:GTP", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10549052", "map_id": "none", "name": "p-EPHBs:EFNBs:RASA1:HRAS:GDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10548566", "map_id": "none", "name": "EPH receptors autophosphorylate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10548563", "map_id": "none", "name": "p-EPH:ephrin oligomers", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10548601", "map_id": "none", "name": "EPH:EFN dimers tetramerise", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10548768", "map_id": "none", "name": "bPIX exchanges GTP for GDP on RAC, activating it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10548718", "map_id": "none", "name": "EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q19467", "map_id": "Q19467", "name": "git-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008805", "map_id": "WBGene00008805", "name": "git-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_114549", "map_id": "CHEBI:17552", "name": "GDP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10548720", "map_id": "none", "name": "EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10548770", "map_id": "none", "name": "p-EFNB binds GRB4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10518535", "map_id": "Q95PX0", "name": "nck-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10548675", "map_id": "none", "name": "EPHBs:p-3Y-EFNBs:SRC,FYN", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10548677", "map_id": "none", "name": "EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10548691", "map_id": "none", "name": "EFNBs bind SFKs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10548620", "map_id": "none", "name": "SRC,FYN", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10548689", "map_id": "none", "name": "EPHBs:EFNBs:SRC,FYN", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10548739", "map_id": "none", "name": "PAKs autophosphorylate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10548724", "map_id": "none", "name": "EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP:PAK1,3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10548736", "map_id": "none", "name": "EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP:p-PAK1,3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10548773", "map_id": "none", "name": "PAKs phosphorylate MLC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10525019", "map_id": "Q09510", "name": "mlc-4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10524835", "map_id": "Q09510", "name": "phospho-mlc-4", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10548775", "map_id": "none", "name": "PAK binds RAC and bPIX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10548722", "map_id": "none", "name": "PAK1/3, 2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10548765", "map_id": "none", "name": "GIT1 binds bPIX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10548685", "map_id": "none", "name": "EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10512284", "map_id": "Q21430", "name": "pix-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10548687", "map_id": "none", "name": "EFNB:GRB4 binds GIT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10548683", "map_id": "Q19467", "name": "phospho-git-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10548716", "map_id": "none", "name": "EPHBs bind EFNBs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10548493", "map_id": "O61460", "name": "vab-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10548796", "map_id": "none", "name": "NGEF exchanges GTP for GDP on RHOA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10548793", "map_id": "none", "name": "EFNAs:p-EPHAs:SFKs:p-Y179-NGEF", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10573063", "map_id": "none", "name": "DKC1 binds SHQ1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10510127", "map_id": "O17919", "name": "DKC1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00010478", "map_id": "WBGene00010478", "name": "DKC1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10573059", "map_id": "Q9TYM6", "name": "SHQ1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00021655", "map_id": "WBGene00021655", "name": "SHQ1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10573061", "map_id": "none", "name": "DKC1:SHQ1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9TYM6", "map_id": "Q9TYM6", "name": "SHQ1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O17919", "map_id": "O17919", "name": "DKC1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10528993", "map_id": "none", "name": "GCNTs transfer GlcNAc from UDP-GlcNAc to Core 1 mucins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "species_10528918", "map_id": "none", "name": "Core 1 mucins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "species_10528926", "map_id": "none", "name": "Core 2 mucins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "species_10528990", "map_id": "none", "name": "GCNTs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "G5EEZ8", "map_id": "G5EEZ8", "name": "gly-15", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001640", "map_id": "WBGene00001640", "name": "gly-15", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EBK7", "map_id": "G5EBK7", "name": "gly-19", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001644", "map_id": "WBGene00001644", "name": "gly-19", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O02315", "map_id": "O02315", "name": "gly-17", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001642", "map_id": "WBGene00001642", "name": "gly-17", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5ECK8", "map_id": "G5ECK8", "name": "gly-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001626", "map_id": "WBGene00001626", "name": "gly-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q19730", "map_id": "Q19730", "name": "gly-18", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001643", "map_id": "WBGene00001643", "name": "gly-18", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EDP7", "map_id": "G5EDP7", "name": "gly-16", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001641", "map_id": "WBGene00001641", "name": "gly-16", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10528675", "map_id": "none", "name": "Addition of galactose to the Tn antigen via an alpha-1,3 linkage forms a Core 8 glycoprotein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "species_10528570", "map_id": "none", "name": "Tn antigens", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "species_10528673", "map_id": "none", "name": "Core 8 mucins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "reaction_10529014", "map_id": "none", "name": "Addition of GlcNAc to Core 3 forms a Core 4 glycoprotein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10528693", "map_id": "none", "name": "Core 3 mucins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "species_10529011", "map_id": "none", "name": "Core 4 mucins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "species_10528960", "map_id": "G5EEZ8", "name": "gly-15", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "reaction_10538297", "map_id": "none", "name": "C1GALT1 transfers Galactose to the Tn antigen forming Core 1 glycoproteins (T antigens)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10538294", "map_id": "none", "name": "C1GALT1:C1GALT1C1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "Q18515", "map_id": "Q18515", "name": "C1GALT1C1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021403", "map_id": "WBGene00021403", "name": "C1GALT1C1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O44563", "map_id": "O44563", "name": "bus-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00044620", "map_id": "WBGene00044620", "name": "bus-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O17053", "map_id": "O17053", "name": "C1GALT1C1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q22900", "map_id": "Q22900", "name": "C1GALT1C1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O45579", "map_id": "O45579", "name": "C1GALT1C1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O17747", "map_id": "O17747", "name": "C1GALT1C1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5ECT3", "map_id": "G5ECT3", "name": "C1GALT1C1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P41881", "map_id": "P41881", "name": "C1GALT1C1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O18184", "map_id": "O18184", "name": "C1GALT1C1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O16535", "map_id": "O16535", "name": "C1GALT1C1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10528665", "map_id": "none", "name": "Addition of GlcNAc to the Tn antigen via an alpha-1,3 linkage forms a Core 5 glycoprotein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "species_10528663", "map_id": "none", "name": "Core 5 mucins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "reaction_10529003", "map_id": "none", "name": "Addition of GalNAc to the Tn antigen via an alpha-1,6 linkage forms a Core 7 glycoprotein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "species_10529001", "map_id": "none", "name": "Core 7 mucins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "reaction_10528685", "map_id": "none", "name": "Addition of GlcNAc to the Tn antigen via a beta-1,6 linkage forms a Core 6 glycoprotein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "species_10528683", "map_id": "none", "name": "Core 6 mucins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "reaction_10528910", "map_id": "none", "name": "Addition of GlcNAc to the Tn antigen forms a Core 3 glycoprotein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10528907", "map_id": "none", "name": "B3GNTs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "Q9XU74", "map_id": "Q9XU74", "name": "B3GNT6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011780", "map_id": "WBGene00011780", "name": "B3GNT6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O62163", "map_id": "O62163", "name": "B3GNT6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "H2L0F4", "map_id": "H2L0F4", "name": "bus-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00044618", "map_id": "WBGene00044618", "name": "bus-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O62165", "map_id": "O62165", "name": "B3GNT6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O02231", "map_id": "O02231", "name": "B3GNT6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O62375", "map_id": "O62375", "name": "B3GNT6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O02310", "map_id": "O02310", "name": "B3GNT6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q20575", "map_id": "Q20575", "name": "B3GNT6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O17750", "map_id": "O17750", "name": "B3GNT6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q6QMT2", "map_id": "Q6QMT2", "name": "bre-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000267", "map_id": "WBGene00000267", "name": "bre-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O62114", "map_id": "O62114", "name": "B3GNT6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5ECA6", "map_id": "G5ECA6", "name": "B3GNT6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8MQG4", "map_id": "Q8MQG4", "name": "B3GNT6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O62115", "map_id": "O62115", "name": "B3GNT6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EDB3", "map_id": "G5EDB3", "name": "bus-17", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00044630", "map_id": "WBGene00044630", "name": "bus-17", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10528639", "map_id": "none", "name": "GALNTs transfer GalNAc from UDP-GalNAc to mucins to form Tn antigens", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10528562", "map_id": "none", "name": "Mucins", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "species_10528636", "map_id": "none", "name": "GALNTs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "O61397", "map_id": "O61397", "name": "gly-7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001632", "map_id": "WBGene00001632", "name": "gly-7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q95ZJ1", "map_id": "Q95ZJ1", "name": "gly-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001630", "map_id": "WBGene00001630", "name": "gly-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34678", "map_id": "P34678", "name": "gly-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001628", "map_id": "WBGene00001628", "name": "gly-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7K755", "map_id": "Q7K755", "name": "gly-11", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001636", "map_id": "WBGene00001636", "name": "gly-11", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9U2C4", "map_id": "Q9U2C4", "name": "gly-9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012934", "map_id": "WBGene00012934", "name": "gly-9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10550347", "map_id": "none", "name": "POFUT2 transfers fucose to TSR domain-containing proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10550339", "map_id": "none", "name": "POFUT2 substrates", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "Q19305", "map_id": "Q19305", "name": "spon-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006893", "map_id": "WBGene00006893", "name": "spon-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5ECS8", "map_id": "G5ECS8", "name": "adt-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000082", "map_id": "WBGene00000082", "name": "adt-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q19791", "map_id": "Q19791", "name": "gon-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001650", "map_id": "WBGene00001650", "name": "gon-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O76840", "map_id": "O76840", "name": "mig-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003242", "map_id": "WBGene00003242", "name": "mig-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10550147", "map_id": "none", "name": "O-fuc-proteins", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "species_10550344", "map_id": "Q8WR51", "name": "pad-2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "WBGene00010757", "map_id": "WBGene00010757", "name": "pad-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10550251", "map_id": "none", "name": "B3GALTL transfers glucose to O-fucosyl-proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10550243", "map_id": "none", "name": "glc-fuc-proteins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "species_10550248", "map_id": "O01878", "name": "B3GALTL", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "WBGene00022576", "map_id": "WBGene00022576", "name": "B3GALTL", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10532278", "map_id": "none", "name": "Proteasomal clevage of exogenous antigen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1236719", "map_id": "CHEBI:16670", "name": "Exogenous soluble antigen", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_8942986", "map_id": "CHEBI:59869", "name": "L-amino acid", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_983036", "map_id": "CHEBI:25676", "name": "precursor peptide fragment (>16 aa)", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10534835", "map_id": "none", "name": "2-MAG and DAG are transacylated to TAG by PNPLA2/3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_1498728", "map_id": "CHEBI:17389", "name": "2-MAG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_1500594", "map_id": "CHEBI:17855", "name": "TAG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10534832", "map_id": "none", "name": "PNPLA2/3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q18948", "map_id": "Q18948", "name": "PNPLA5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00015241", "map_id": "WBGene00015241", "name": "PNPLA5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9N5Z7", "map_id": "Q9N5Z7", "name": "PNPLA5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10534837", "map_id": "none", "name": "2-MAG is transacylated to DAG by PNPLA2/3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "reaction_10534887", "map_id": "none", "name": "DAG is hydrolyzed to 2-MAG by PNPLA2/3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "reaction_10534873", "map_id": "none", "name": "TAG is hydrolyzed to DAG by PNPLA2/3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "reaction_10534923", "map_id": "none", "name": "DAG is acylated to TAG by DGAT1/2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10534920", "map_id": "none", "name": "DGAT1/2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10557644", "map_id": "none", "name": "AWAT2 transfers acyl group from acyl-CoA to MAG, forming DAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_5696449", "map_id": "CHEBI:17408", "name": "MAG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_6782195", "map_id": "CHEBI:17984", "name": "Acyl-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10557641", "map_id": "none", "name": "Homologues of AWAT2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10564718", "map_id": "none", "name": "DGAT2L6,L7P transfer acyl group from acyl-CoA to DAG, forming TAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10564715", "map_id": "none", "name": "DGAT2L6,L7P", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10517713", "map_id": "none", "name": "Prostaglandin E synthase isomerizes PGH2 to PGE2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_265283", "map_id": "CHEBI:15554", "name": "PGH2", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10517710", "map_id": "none", "name": "PTGES2(88-377), PTGES3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10542977", "map_id": "none", "name": "PGD2 is reduced to 11-epi-PGF2a by AKRIC3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_2142710", "map_id": "CHEBI:27595", "name": "11epi-PGF2a", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10542982", "map_id": "none", "name": "PGH2 is isomerised to PGD2 by HPGDS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10542979", "map_id": "none", "name": "HPGDS dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10542974", "map_id": "none", "name": "PGH2 is reduced to PGF2a by AKR1C3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10569857", "map_id": "none", "name": "SMDT1 assists in assembling MCU, MCUB, MICU1, MICU2 (or MICU3) yielding the MCU complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane" }, { "id": "species_10568878", "map_id": "Q9U3I4", "name": "emre-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "WBGene00008980", "map_id": "WBGene00008980", "name": "emre-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10568873", "map_id": "Q95PZ2", "name": "micu-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "WBGene00013462", "map_id": "WBGene00013462", "name": "micu-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10568887", "map_id": "none", "name": "MICU2,3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "Q18874", "map_id": "Q18874", "name": "MICU3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008345", "map_id": "WBGene00008345", "name": "MICU3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10568868", "map_id": "Q21121", "name": "mcu-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "WBGene00019296", "map_id": "WBGene00019296", "name": "mcu-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10568866", "map_id": "Q21121", "name": "mcu-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "species_10568889", "map_id": "none", "name": "MCU complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "Q21121", "map_id": "Q21121", "name": "mcu-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q95PZ2", "map_id": "Q95PZ2", "name": "micu-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9U3I4", "map_id": "Q9U3I4", "name": "emre-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10568954", "map_id": "none", "name": "PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane" }, { "id": "species_10568937", "map_id": "none", "name": "proSMDT1:C2orf47:AFG3L2:SPG7:PHB:PHB2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "P54813", "map_id": "P54813", "name": "ymel-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010842", "map_id": "WBGene00010842", "name": "ymel-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9N3T5", "map_id": "Q9N3T5", "name": "spg-7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004978", "map_id": "WBGene00004978", "name": "spg-7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9BKU4", "map_id": "Q9BKU4", "name": "phb-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P50093", "map_id": "P50093", "name": "phb-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004015", "map_id": "WBGene00004015", "name": "phb-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q2HQK3", "map_id": "Q2HQK3", "name": "C2orf47", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00044745", "map_id": "WBGene00044745", "name": "C2orf47", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EDB6", "map_id": "G5EDB6", "name": "ppgn-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021425", "map_id": "WBGene00021425", "name": "ppgn-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10568939", "map_id": "Q9U3I4", "name": "emre-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10568933", "map_id": "none", "name": "C2orf47:AFG3L2:SPG7:PHB:PHB2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "species_10568951", "map_id": "none", "name": "Mitochondrial processing peptidase", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "Q95XN2", "map_id": "Q95XN2", "name": "mppa-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022159", "map_id": "WBGene00022159", "name": "mppa-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q23295", "map_id": "Q23295", "name": "mppb-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013880", "map_id": "WBGene00013880", "name": "mppb-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10568957", "map_id": "none", "name": "AFG3L2 (m-AAA protease) degrades SMDT1 that is not assembled in MCU", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane" }, { "id": "reaction_10568959", "map_id": "none", "name": "C2orf47:AFG3L2 binds the transit peptide of SMDT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane" }, { "id": "species_10568935", "map_id": "Q9U3I4", "name": "emre-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "reaction_10568964", "map_id": "none", "name": "SLC8B1 (NCLX) exchanges sodium (mitochondrial intermembrane space) for calcium (mitochondrial matrix)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane" }, { "id": "species_2889072", "map_id": "CHEBI:29101", "name": "Na+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "false" }, { "id": "species_8949220", "map_id": "CHEBI:29108", "name": "Ca2+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_8949232", "map_id": "CHEBI:29108", "name": "Ca2+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "false" }, { "id": "species_2889083", "map_id": "CHEBI:29101", "name": "Na+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10568961", "map_id": "P34322", "name": "ncx-7", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "WBGene00003572", "map_id": "WBGene00003572", "name": "ncx-7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10568892", "map_id": "none", "name": "MCU translocates calcium from the mitochondrial intermembrane space to the mitochondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane" }, { "id": "reaction_10505728", "map_id": "none", "name": "Formation of eIF2:GDP:eIF2B intermediate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10505724", "map_id": "none", "name": "eIF2B subunits complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "G5EFF9", "map_id": "G5EFF9", "name": "eif-2bdelta", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008670", "map_id": "WBGene00008670", "name": "eif-2bdelta", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q18994", "map_id": "Q18994", "name": "eif-2bepsilon", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008428", "map_id": "WBGene00008428", "name": "eif-2bepsilon", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34604", "map_id": "P34604", "name": "EIF2B1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00014221", "map_id": "WBGene00014221", "name": "EIF2B1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P80361", "map_id": "P80361", "name": "eif-2Bgamma", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004090", "map_id": "WBGene00004090", "name": "eif-2Bgamma", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XWD5", "map_id": "Q9XWD5", "name": "eif-2bbeta", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012950", "map_id": "WBGene00012950", "name": "eif-2bbeta", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10505685", "map_id": "none", "name": "eIF2:GDP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10505726", "map_id": "none", "name": "eIF2:GDP: eIF2B", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10506002", "map_id": "none", "name": "eIF2 activation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10505633", "map_id": "none", "name": "eIF2:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10508240", "map_id": "none", "name": "(S)-Hydroxybutanoyl-CoA+NAD<=>Acetoacetyl-CoA+NADH+H", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_77251", "map_id": "CHEBI:15453", "name": "3HB-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_73871", "map_id": "CHEBI:15345", "name": "ACA-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10508242", "map_id": "none", "name": "Crotonoyl-CoA+H2O<=>(S)-3-Hydroxybutanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_77313", "map_id": "CHEBI:15473", "name": "Crotonoyl-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10552459", "map_id": "none", "name": "KCND tetramer:KCNIP tetramer transport K+ from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10552456", "map_id": "none", "name": "KCND tetramer:KCNIP tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q95XD1", "map_id": "Q95XD1", "name": "shl-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022240", "map_id": "WBGene00022240", "name": "shl-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O45313", "map_id": "O45313", "name": "ncs-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008307", "map_id": "WBGene00008307", "name": "ncs-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A4V0IK35", "map_id": "A0A4V0IK35", "name": "ncs-7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00015867", "map_id": "WBGene00015867", "name": "ncs-7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EGM2", "map_id": "G5EGM2", "name": "ncs-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008998", "map_id": "WBGene00008998", "name": "ncs-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O16638", "map_id": "O16638", "name": "ncs-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021116", "map_id": "WBGene00021116", "name": "ncs-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10571473", "map_id": "none", "name": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9022655", "map_id": "CHEBI:138490", "name": "5S,6S-epoxy-18(S)-HEPE", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_9022660", "map_id": "CHEBI:137038", "name": "18(S)-RvE1", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10571478", "map_id": "none", "name": "GPX4-2 reduces 18(S)-HpEPE to 18(S)-HEPE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9020583", "map_id": "CHEBI:138387", "name": "18(S)-HpEPE", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_9020474", "map_id": "CHEBI:132801", "name": "18(S)-HEPE", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10521687", "map_id": "none", "name": "SEMA4A binds to PLXND1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10521671", "map_id": "none", "name": "Homologues of PLXND1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10521683", "map_id": "none", "name": "Homologues of SEMA4A", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9TYS4", "map_id": "Q9TYS4", "name": "smp-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004890", "map_id": "WBGene00004890", "name": "smp-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q17330", "map_id": "Q17330", "name": "smp-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004889", "map_id": "WBGene00004889", "name": "smp-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q95XP4", "map_id": "Q95XP4", "name": "mab-20", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003111", "map_id": "WBGene00003111", "name": "mab-20", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10521685", "map_id": "none", "name": "SEMA4A:PLXND1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10521675", "map_id": "none", "name": "SEMA3E binds to PLXND1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10521665", "map_id": "none", "name": "Homologues of SEMA3E", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10521673", "map_id": "none", "name": "SEMA3A:PLXND1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10524174", "map_id": "none", "name": "SEMA7A binds to PLXNC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10524170", "map_id": "none", "name": "Homologues of SEMA7A", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10524162", "map_id": "none", "name": "Homologues of PLXNC1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10524172", "map_id": "none", "name": "SEMA7A:PLXNC1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10508448", "map_id": "none", "name": "Recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10507139", "map_id": "none", "name": "pol II promoter:TFIID:TFIIA:TFIIB complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10507141", "map_id": "none", "name": "pol II promoter:TFIID:TFIIA:TFIIB:Pol II:TFIIF complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10508450", "map_id": "none", "name": "Formation of the closed pre-initiation complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10507143", "map_id": "none", "name": "pol II promoter:TFIID:TFIIA:TFIIB:Pol II:TFIIF:TFIIE complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10507145", "map_id": "none", "name": "Binding of TFIIE to the growing preinitiation complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10508444", "map_id": "none", "name": "Recognition and Binding of Core Promoter Elements by TFIID", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_109627", "map_id": "none", "name": "DNA containing RNA Polymerase II promoter", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10507137", "map_id": "none", "name": "pol II promoter:TFIID complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10508446", "map_id": "none", "name": "Binding of TFIIA and TFIIB to the pol II promoter:TFIID complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10532932", "map_id": "none", "name": "Activation of TALK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10532929", "map_id": "none", "name": "TALK 1and 2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "O45891", "map_id": "O45891", "name": "twk-42", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006692", "map_id": "WBGene00006692", "name": "twk-42", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5ED42", "map_id": "G5ED42", "name": "twk-16", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006670", "map_id": "WBGene00006670", "name": "twk-16", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q65XY3", "map_id": "Q65XY3", "name": "twk-49", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019904", "map_id": "WBGene00019904", "name": "twk-49", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q18261", "map_id": "Q18261", "name": "KCNK17", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016168", "map_id": "WBGene00016168", "name": "KCNK17", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EEH1", "map_id": "G5EEH1", "name": "twk-43", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006693", "map_id": "WBGene00006693", "name": "twk-43", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q6BES3", "map_id": "Q6BES3", "name": "twk-24", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006677", "map_id": "WBGene00006677", "name": "twk-24", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q19525", "map_id": "Q19525", "name": "twk-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006661", "map_id": "WBGene00006661", "name": "twk-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "I2HAD3", "map_id": "I2HAD3", "name": "twk-23", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006676", "map_id": "WBGene00006676", "name": "twk-23", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q93732", "map_id": "Q93732", "name": "twk-29", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006681", "map_id": "WBGene00006681", "name": "twk-29", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "C0Z3L1", "map_id": "C0Z3L1", "name": "egl-23", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001190", "map_id": "WBGene00001190", "name": "egl-23", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q23435", "map_id": "Q23435", "name": "twk-9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006664", "map_id": "WBGene00006664", "name": "twk-9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10532792", "map_id": "none", "name": "Activation of TWIK-related K+ channel (TREK)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10532789", "map_id": "none", "name": "TREK homodimers", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "G5ECW6", "map_id": "G5ECW6", "name": "twk-20", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006673", "map_id": "WBGene00006673", "name": "twk-20", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O17185", "map_id": "O17185", "name": "sup-9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006318", "map_id": "WBGene00006318", "name": "sup-9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10532802", "map_id": "none", "name": "Activation of THIK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10532799", "map_id": "none", "name": "THIK1 homodimers", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "F5GUD1", "map_id": "F5GUD1", "name": "twk-14", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006669", "map_id": "WBGene00006669", "name": "twk-14", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10532833", "map_id": "none", "name": "Activation of tandem pore domain in a weak inwardly rectifying K+ channels", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10532830", "map_id": "none", "name": "TWIK channels", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q10937", "map_id": "Q10937", "name": "KCNK1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00015137", "map_id": "WBGene00015137", "name": "KCNK1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9NEV3", "map_id": "Q9NEV3", "name": "twk-46", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006696", "map_id": "WBGene00006696", "name": "twk-46", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10532854", "map_id": "none", "name": "Activation of TASK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10532851", "map_id": "none", "name": "TASK", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10532864", "map_id": "none", "name": "Activation of TRESK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10532861", "map_id": "none", "name": "TRESK homodimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q22043", "map_id": "Q22043", "name": "twk-22", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006675", "map_id": "WBGene00006675", "name": "twk-22", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10532761", "map_id": "none", "name": "KCNJs transport K+ from the extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10532758", "map_id": "none", "name": "KCNJ tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10532746", "map_id": "none", "name": "Activation of Potassium transport channels", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10532743", "map_id": "none", "name": "Potassium transport channels (Kir 1.1 and Kir 4.1/5.1)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10566209", "map_id": "none", "name": "CBFB binds RUNX3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10566207", "map_id": "none", "name": "RUNX3:CBFB", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10568338", "map_id": "none", "name": "RUNX3 binds SRC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10568334", "map_id": "G5EFQ5", "name": "rnt-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10568336", "map_id": "none", "name": "MyrG-p-Y419-SRC:RUNX3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10569702", "map_id": "none", "name": "Polyubiquitinated RUNX3 translocates to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10569698", "map_id": "G5EFQ5", "name": "rnt-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10569700", "map_id": "G5EFQ5", "name": "rnt-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10568344", "map_id": "none", "name": "SRC phosphorylates RUNX3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10568341", "map_id": "G5EFQ5", "name": "phospho-rnt-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10569704", "map_id": "none", "name": "Polyubiquitinated RUNX3 is degraded by the proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10568346", "map_id": "none", "name": "RUNX3 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10518768", "map_id": "none", "name": "L1 interaction with Integrins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10518764", "map_id": "none", "name": "Integrins", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10518766", "map_id": "none", "name": "L1:Integrin complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10524706", "map_id": "none", "name": "Activation of Rac1 by VAV2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10524306", "map_id": "Q45FX5", "name": "phospho-vav-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10524710", "map_id": "none", "name": "L1-EGFR trans-heterodimerization", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10524708", "map_id": "none", "name": "L1-EGFR trans-heterodimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10521079", "map_id": "none", "name": "Phosphorylation of L1 by CK-II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10521077", "map_id": "none", "name": "pL1:CK-II", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10518762", "map_id": "none", "name": "L1 and NCAM1 engaged in cis-interaction", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10518758", "map_id": "C6KRM7", "name": "rig-5", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10518760", "map_id": "none", "name": "L1:NCAM1 complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10524715", "map_id": "none", "name": "Interaction of PAK1 with Rac1-GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10524712", "map_id": "none", "name": "pPAK1:Rac1-GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10516546", "map_id": "none", "name": "SLC1A1-3,6,7 exchange L-Glu, H+ and 3Na+ for K+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10516538", "map_id": "none", "name": "SLC1A1-3,6,7", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q21353", "map_id": "Q21353", "name": "glt-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001621", "map_id": "WBGene00001621", "name": "glt-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q21751", "map_id": "Q21751", "name": "glt-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001624", "map_id": "WBGene00001624", "name": "glt-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q22682", "map_id": "Q22682", "name": "glt-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001622", "map_id": "WBGene00001622", "name": "glt-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9UAY8", "map_id": "Q9UAY8", "name": "glt-7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001625", "map_id": "WBGene00001625", "name": "glt-7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O18210", "map_id": "O18210", "name": "glt-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001623", "map_id": "WBGene00001623", "name": "glt-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q10901", "map_id": "Q10901", "name": "glt-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001620", "map_id": "WBGene00001620", "name": "glt-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10516544", "map_id": "H2KZJ7", "name": "praf-3", "type": "inhibitor", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00017070", "map_id": "WBGene00017070", "name": "praf-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10516838", "map_id": "none", "name": "L-Glutamate loading of synaptic vesicle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10516835", "map_id": "none", "name": "Empty Glutamate Synaptic Vesicle", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P34644", "map_id": "P34644", "name": "eat-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001135", "map_id": "WBGene00001135", "name": "eat-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q10046", "map_id": "Q10046", "name": "vglu-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011556", "map_id": "WBGene00011556", "name": "vglu-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EEK1", "map_id": "G5EEK1", "name": "vglu-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010755", "map_id": "WBGene00010755", "name": "vglu-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10516719", "map_id": "none", "name": "Glutamate loaded synaptic vesicle", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10516828", "map_id": "none", "name": "Release of L-Glutamate at the synapse", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10516779", "map_id": "none", "name": "Docked Glutamate Loaded Synaptic Vesicle", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10516809", "map_id": "none", "name": "SNARE complex:Ca2+", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10516791", "map_id": "none", "name": "Homologues of SLC17A7", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10516782", "map_id": "none", "name": "Glutamate synaptic vesicle docking and priming", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10516759", "map_id": "P27715", "name": "unc-13", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10543028", "map_id": "none", "name": "DeMQ10H2 is methylated to Q10H2 by COQ3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_2162212", "map_id": "CHEBI:64182", "name": "DeMQ10H2", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_2162198", "map_id": "CHEBI:64183", "name": "Q10H2", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10543025", "map_id": "O18235", "name": "coq-3", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "WBGene00000763", "map_id": "WBGene00000763", "name": "coq-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10543036", "map_id": "none", "name": "PHB and all-E-10PrP2 are combined into DHB by COQ2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane" }, { "id": "species_2162214", "map_id": "CHEBI:61011", "name": "all-E-10PrP2", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_2162213", "map_id": "CHEBI:30763", "name": "PHB", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_2162207", "map_id": "CHEBI:64136", "name": "DHB", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10543033", "map_id": "Q8I7J4", "name": "coq-2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "WBGene00000762", "map_id": "WBGene00000762", "name": "coq-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10543039", "map_id": "none", "name": "DHDB is methylated to MHDB by COQ3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_2162209", "map_id": "CHEBI:50775", "name": "DHDB", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_2162215", "map_id": "CHEBI:50776", "name": "MHDB", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10518304", "map_id": "none", "name": "Acetylcholine synaptic vesicle docking and priming", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10517503", "map_id": "none", "name": "Acetylcholine Loaded Synaptic Vesicle", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P34711", "map_id": "P34711", "name": "unc-17", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006756", "map_id": "WBGene00006756", "name": "unc-17", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10518301", "map_id": "none", "name": "Docked acetylcholine loaded Synaptic Vesicle", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10518401", "map_id": "none", "name": "Release of acetylcholine at the synapse", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10518398", "map_id": "P34711", "name": "unc-17", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10517506", "map_id": "none", "name": "Loading of acetylcholine in synaptic vesicles", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10517501", "map_id": "none", "name": "Empty Acetylcholine Synaptic Vesicle", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_372511", "map_id": "CHEBI:15378", "name": "H+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_372525", "compartment_display": "clathrin-sculpted acetylcholine transport vesicle lumen", "complex": "false" }, { "id": "species_264643", "map_id": "CHEBI:15355", "name": "AcCho", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10517483", "map_id": "P34711", "name": "unc-17", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_373334", "compartment_display": "clathrin-sculpted acetylcholine transport vesicle membrane", "complex": "false" }, { "id": "reaction_10517514", "map_id": "none", "name": "Cho is acetylated to AcCho by CHAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10517511", "map_id": "P32756", "name": "cha-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00000481", "map_id": "WBGene00000481", "name": "cha-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10554130", "map_id": "none", "name": "RP2 binds ARL3:GTP:UNC119B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_18730", "compartment_display": "cilium" }, { "id": "species_10554126", "map_id": "Q966I6", "name": "rpi-2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_18730", "compartment_display": "cilium", "complex": "false" }, { "id": "WBGene00019536", "map_id": "WBGene00019536", "name": "rpi-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10554121", "map_id": "none", "name": "ARL3:GTP:UNC119B", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_18730", "compartment_display": "cilium", "complex": "true" }, { "id": "O45379", "map_id": "O45379", "name": "arl-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000188", "map_id": "WBGene00000188", "name": "arl-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q10658", "map_id": "Q10658", "name": "unc-119", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006843", "map_id": "WBGene00006843", "name": "unc-119", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10554128", "map_id": "none", "name": "RP2:ARL3:GTP:UNC119B", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_18730", "compartment_display": "cilium", "complex": "true" }, { "id": "Q966I6", "map_id": "Q966I6", "name": "rpi-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10554148", "map_id": "none", "name": "RP2:ARL3:GDP:UNC119B dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_18730", "compartment_display": "cilium" }, { "id": "species_10554134", "map_id": "none", "name": "RP2:ARL3:GDP:UNC119B", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_18730", "compartment_display": "cilium", "complex": "true" }, { "id": "species_10554119", "map_id": "Q10658", "name": "unc-119", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_18730", "compartment_display": "cilium", "complex": "false" }, { "id": "species_10554132", "map_id": "none", "name": "ARL3:GDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_18730", "compartment_display": "cilium", "complex": "true" }, { "id": "reaction_10554137", "map_id": "none", "name": "ARL3 hydrolyzes GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_18730", "compartment_display": "cilium" }, { "id": "reaction_10554140", "map_id": "none", "name": "RP2 activates the GTPase activity of ARL3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_18730", "compartment_display": "cilium" }, { "id": "reaction_10553222", "map_id": "none", "name": "VxPx-containing ciliary membrane proteins are delivered to the ciliary membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_261122", "compartment_display": "ciliary membrane" }, { "id": "species_10553196", "map_id": "none", "name": "exocyst complex:RAB8A:GTP:RAB3IP:RAB11:GTP:RAB11FIP3 dimer:ASAP1 dimer:VxPx-containing ciliary membrane proteins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_13949", "compartment_display": "Golgi-associated vesicle membrane", "complex": "true" }, { "id": "O01803", "map_id": "O01803", "name": "rab-11.1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004274", "map_id": "WBGene00004274", "name": "rab-11.1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q95ZS6", "map_id": "Q95ZS6", "name": "rfip-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018869", "map_id": "WBGene00018869", "name": "rfip-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q20759", "map_id": "Q20759", "name": "RAB3IL1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010045", "map_id": "WBGene00010045", "name": "RAB3IL1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EFC1", "map_id": "G5EFC1", "name": "rab-8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004272", "map_id": "WBGene00004272", "name": "rab-8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q21137", "map_id": "Q21137", "name": "GGC-RAB8A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019317", "map_id": "WBGene00019317", "name": "GGC-RAB8A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XWS2", "map_id": "Q9XWS2", "name": "sec-8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004753", "map_id": "WBGene00004753", "name": "sec-8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q18406", "map_id": "Q18406", "name": "sec-10", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016376", "map_id": "WBGene00016376", "name": "sec-10", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q18286", "map_id": "Q18286", "name": "sec-15", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016188", "map_id": "WBGene00016188", "name": "sec-15", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P91149", "map_id": "P91149", "name": "exoc-7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016606", "map_id": "WBGene00016606", "name": "exoc-7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q95Q35", "map_id": "Q95Q35", "name": "exoc-8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013687", "map_id": "WBGene00013687", "name": "exoc-8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q20678", "map_id": "Q20678", "name": "sec-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018703", "map_id": "WBGene00018703", "name": "sec-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q22706", "map_id": "Q22706", "name": "sec-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004752", "map_id": "WBGene00004752", "name": "sec-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q19262", "map_id": "Q19262", "name": "sec-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017284", "map_id": "WBGene00017284", "name": "sec-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10553220", "map_id": "none", "name": "VxPx-containing ciliary membrane proteins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_261122", "compartment_display": "ciliary membrane", "complex": "true" }, { "id": "reaction_10553129", "map_id": "none", "name": "GBF1 stimulates nucleotide exchange on ARF4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10553127", "map_id": "none", "name": "ARF4:GDP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10553068", "map_id": "none", "name": "ARF4:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10517992", "map_id": "G5EGS5", "name": "gbf-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "reaction_10553198", "map_id": "none", "name": "The exocyst complex binds to RAB3IP in the ciliary targeting complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13949", "compartment_display": "Golgi-associated vesicle membrane" }, { "id": "species_10553194", "map_id": "none", "name": "exocyst complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10553176", "map_id": "none", "name": "RAB8A:GTP:RAB3IP:RAB11A:GTP:RAB11FIP3 dimer:ASAP1 dimer:VxPx-containing ciliary membrane proteins", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_13949", "compartment_display": "Golgi-associated vesicle membrane", "complex": "true" }, { "id": "reaction_10553265", "map_id": "none", "name": "Formation of the BBSome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10552766", "map_id": "Q9NEZ7", "name": "bbs-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00000241", "map_id": "WBGene00000241", "name": "bbs-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10552796", "map_id": "Q23049", "name": "bbs-8", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00000244", "map_id": "WBGene00000244", "name": "bbs-8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10552781", "map_id": "Q21626", "name": "bbs-5", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00010974", "map_id": "WBGene00010974", "name": "bbs-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10552776", "map_id": "Q5CZ52", "name": "bbs-4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00043992", "map_id": "WBGene00043992", "name": "bbs-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10552791", "map_id": "O01514", "name": "bbs-9", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00016744", "map_id": "WBGene00016744", "name": "bbs-9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10552786", "map_id": "Q9XW70", "name": "osm-12", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00003892", "map_id": "WBGene00003892", "name": "osm-12", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10552771", "map_id": "Q19640", "name": "bbs-2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00000242", "map_id": "WBGene00000242", "name": "bbs-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10552801", "map_id": "Q21273", "name": "BBIP1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00019482", "map_id": "WBGene00019482", "name": "BBIP1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10552803", "map_id": "none", "name": "BBSome", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q21273", "map_id": "Q21273", "name": "BBIP1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q19640", "map_id": "Q19640", "name": "bbs-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XW70", "map_id": "Q9XW70", "name": "osm-12", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O01514", "map_id": "O01514", "name": "bbs-9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q5CZ52", "map_id": "Q5CZ52", "name": "bbs-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q21626", "map_id": "Q21626", "name": "bbs-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q23049", "map_id": "Q23049", "name": "bbs-8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9NEZ7", "map_id": "Q9NEZ7", "name": "bbs-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10553298", "map_id": "none", "name": "ARL6:GTP and the BBSome bind ciliary cargo", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10553294", "map_id": "none", "name": "BBSome ciliary cargo", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10553272", "map_id": "none", "name": "ARL6:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q18510", "map_id": "Q18510", "name": "arl-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000193", "map_id": "WBGene00000193", "name": "arl-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10553296", "map_id": "none", "name": "ARL6:GTP:BBSome:ciliary cargo", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10553354", "map_id": "none", "name": "ARL6:GTP and the BBSome target cargo to the primary cilium", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_261122", "compartment_display": "ciliary membrane" }, { "id": "species_10553346", "map_id": "none", "name": "ARL6:GTP:BBSome:ciliary cargo", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_261122", "compartment_display": "ciliary membrane", "complex": "true" }, { "id": "species_10553352", "map_id": "none", "name": "LZTFL1 oligomer:BBSome", "type": "inhibitor", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10552812", "map_id": "none", "name": "BBSome binds RAB3IP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_2132649", "compartment_display": "ciliary basal body" }, { "id": "species_10552808", "map_id": "Q20759", "name": "RAB3IP", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10552810", "map_id": "none", "name": "RAB3IP:BBSome", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_2132649", "compartment_display": "ciliary basal body", "complex": "true" }, { "id": "reaction_10521804", "map_id": "none", "name": "cGMP is degraded by PDEs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10521801", "map_id": "none", "name": "Phosphodiesterases, dual (cAMP, cGMP) activity", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10514144", "map_id": "none", "name": "CYB5A:heme reduces Asc.- to AscH-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1497805", "map_id": "CHEBI:59513", "name": "Asc.-", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10514130", "map_id": "none", "name": "CYB5A:heme", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "true" }, { "id": "O01816", "map_id": "O01816", "name": "cytb-5.2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020931", "map_id": "WBGene00020931", "name": "cytb-5.2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q93315", "map_id": "Q93315", "name": "cytb-5.1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007848", "map_id": "WBGene00007848", "name": "cytb-5.1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_198816", "map_id": "CHEBI:38290", "name": "AscH-", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10514128", "map_id": "none", "name": "CYB5A:ferriheme", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "true" }, { "id": "CHEBI:36144", "map_id": "CHEBI:36144", "name": "CHEBI:36144", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10514114", "map_id": "none", "name": "SLC2A1,3 transports DeHA from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_198852", "map_id": "CHEBI:58539", "name": "DeHA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_198827", "map_id": "CHEBI:58539", "name": "DeHA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10514111", "map_id": "none", "name": "SLC2A1,3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q21381", "map_id": "Q21381", "name": "SLC2A1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9GYQ1", "map_id": "Q9GYQ1", "name": "SLC2A1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q21382", "map_id": "Q21382", "name": "SLC2A1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q21385", "map_id": "Q21385", "name": "SLC2A1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q5WRR9", "map_id": "Q5WRR9", "name": "SLC2A1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10514195", "map_id": "none", "name": "SLC23A1,2 cotransports AscH-, 2Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10514192", "map_id": "none", "name": "SLC23A1,2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "O18061", "map_id": "O18061", "name": "SLC23A2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021994", "map_id": "WBGene00021994", "name": "SLC23A2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "D6RYE3", "map_id": "D6RYE3", "name": "SLC23A2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q18771", "map_id": "Q18771", "name": "SLC23A2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G8JZM6", "map_id": "G8JZM6", "name": "SLC23A2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9TYX7", "map_id": "Q9TYX7", "name": "SLC23A2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O18057", "map_id": "O18057", "name": "SLC23A2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10514075", "map_id": "none", "name": "GSTO dimers reduce DeHA to AscH-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10514072", "map_id": "none", "name": "GSTO dimers", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10514141", "map_id": "none", "name": "CYB5R3:FAD reduces CYB5A:ferriheme to CYB5A:heme", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10514138", "map_id": "none", "name": "CYB5R3:FAD", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "true" }, { "id": "reaction_10529632", "map_id": "none", "name": "2xPDXK:2xZn2+ phosphorylates PXA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_964945", "map_id": "CHEBI:16410", "name": "PXA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_965146", "map_id": "CHEBI:18335", "name": "PXAP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10529629", "map_id": "none", "name": "2xPDXK:2xZn2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10529648", "map_id": "none", "name": "2xPNPO:2xFMN oxidizes PXAP to PXLP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29390", "map_id": "CHEBI:18405", "name": "PXLP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10529643", "map_id": "none", "name": "2xPNPO:2xFMN", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q20939", "map_id": "Q20939", "name": "PNPO", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018996", "map_id": "WBGene00018996", "name": "PNPO", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10529634", "map_id": "none", "name": "2xPDKX:2xZn2+ phosphorylates PDX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_965053", "map_id": "CHEBI:16709", "name": "PDX", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_964952", "map_id": "CHEBI:28803", "name": "PDXP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10529636", "map_id": "none", "name": "2xPDXK:2xZn2+ phosphorylates PXL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_965131", "map_id": "CHEBI:17310", "name": "PXL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10546502", "map_id": "none", "name": "AOX1 oxidises PXL to PDXate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_3204324", "map_id": "CHEBI:17405", "name": "PDXate", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10546499", "map_id": "none", "name": "2xAOX1:cofactors", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:33722", "map_id": "CHEBI:33722", "name": "CHEBI:33722", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:44074", "map_id": "CHEBI:44074", "name": "CHEBI:44074", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O17892", "map_id": "O17892", "name": "xdh-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010083", "map_id": "WBGene00010083", "name": "xdh-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O61198", "map_id": "O61198", "name": "AOX1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017487", "map_id": "WBGene00017487", "name": "AOX1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q960A1", "map_id": "Q960A1", "name": "gad-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00015057", "map_id": "WBGene00015057", "name": "gad-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10529646", "map_id": "none", "name": "2xPNPO:2xFMN oxidizes PDXP to PXLP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10513776", "map_id": "none", "name": "NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_197220", "map_id": "CHEBI:15763", "name": "NAMN", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_197256", "map_id": "CHEBI:18304", "name": "NAAD", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10513773", "map_id": "none", "name": "NMNAT2:Mg2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "P91851", "map_id": "P91851", "name": "nmat-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009176", "map_id": "WBGene00009176", "name": "nmat-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XXM2", "map_id": "Q9XXM2", "name": "nmat-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012295", "map_id": "WBGene00012295", "name": "nmat-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10514608", "map_id": "none", "name": "NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_8938083", "map_id": "CHEBI:15763", "name": "NAMN", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_8938078", "map_id": "CHEBI:33019", "name": "PPi(3-)", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_8938090", "map_id": "CHEBI:18304", "name": "NAAD", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10514605", "map_id": "none", "name": "4xNMNAT3:4xMg2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "reaction_10523473", "map_id": "none", "name": "SLC5A8 transports monocarboxylates from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_429739", "map_id": "none", "name": "monocarboxylates transported by SLC5A8", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_429748", "map_id": "none", "name": "monocarboxylates transported by SLC5A8", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10523470", "map_id": "O17394", "name": "SLC5A8", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10563652", "map_id": "none", "name": "NUDT12 hydrolyses NADH to NMNH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_6809289", "map_id": "CHEBI:74452", "name": "NMNH", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_10563649", "map_id": "Q19427", "name": "ndx-9", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "WBGene00003586", "map_id": "WBGene00003586", "name": "ndx-9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10563127", "map_id": "none", "name": "CARKD dehydrates S-NAD(P)HX to NADPH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_6807477", "map_id": "CHEBI:64084", "name": "S-NADPHX", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10563124", "map_id": "P32740", "name": "CARKD", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "WBGene00011298", "map_id": "WBGene00011298", "name": "CARKD", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10566729", "map_id": "none", "name": "SLC22A13 transports NCA from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10566726", "map_id": "Q10917", "name": "SLC22A13", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10551672", "map_id": "none", "name": "NNMT transfers CH3 from SAM to NAM to form MNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_197277", "map_id": "CHEBI:17154", "name": "NAM", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10563119", "map_id": "none", "name": "APOA1BP dimer epimerises R-NAD(P)HX to S-NAD(P)HX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_6807473", "map_id": "CHEBI:64085", "name": "R-NADPHX", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10563116", "map_id": "none", "name": "APOA1BP dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q9XW15", "map_id": "Q9XW15", "name": "APOA1BP", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012476", "map_id": "WBGene00012476", "name": "APOA1BP", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10513759", "map_id": "none", "name": "NAPRT1 dimer transfers PRIB to NCA to form NAMN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_73566", "map_id": "CHEBI:17111", "name": "PRPP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10513756", "map_id": "none", "name": "NAPRT1 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10568517", "map_id": "none", "name": "NMNAT2 transfers an adenylyl group from ATP to NMN to yield NAD+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_8869353", "map_id": "CHEBI:14649", "name": "NMN", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10514615", "map_id": "none", "name": "NMNAT1 transfers an adenylyl group from ATP to NAMN to yield NAAD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_200492", "map_id": "CHEBI:15763", "name": "NAMN", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_8878981", "map_id": "CHEBI:33019", "name": "PPi(3-)", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_200499", "map_id": "CHEBI:18304", "name": "NAAD", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10514612", "map_id": "none", "name": "6xNMNAT1:6xZn2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10569958", "map_id": "none", "name": "NADK2 dimer phosphorylates NAD+ to NADP+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10569955", "map_id": "none", "name": "NADK2 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q9XXI5", "map_id": "Q9XXI5", "name": "nadk-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012463", "map_id": "WBGene00012463", "name": "nadk-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10513786", "map_id": "none", "name": "NADSYN1 hexamer amidates NAAD to NAD+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10513783", "map_id": "none", "name": "NADSYN1 hexamer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9XXK6", "map_id": "Q9XXK6", "name": "qns-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007698", "map_id": "WBGene00007698", "name": "qns-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10513714", "map_id": "none", "name": "3xPPCDC:3FMN decarboxylates PPC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_196834", "map_id": "CHEBI:15769", "name": "PPC", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_196767", "map_id": "CHEBI:16858", "name": "PPANT", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10513711", "map_id": "none", "name": "3xPPCDC:3xFMN", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P91988", "map_id": "P91988", "name": "PPCDC", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009138", "map_id": "WBGene00009138", "name": "PPCDC", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10513683", "map_id": "none", "name": "2xPPCS ligates PPanK with Cys", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_196786", "map_id": "CHEBI:15905", "name": "PPanK", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10513680", "map_id": "none", "name": "2xPPCS", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9BL36", "map_id": "Q9BL36", "name": "PPCS", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022171", "map_id": "WBGene00022171", "name": "PPCS", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10513704", "map_id": "none", "name": "COASY phosphorylates DP-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_196778", "map_id": "CHEBI:15468", "name": "DP-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10513688", "map_id": "Q9BL56", "name": "COASY", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "false" }, { "id": "WBGene00022031", "map_id": "WBGene00022031", "name": "COASY", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10513691", "map_id": "none", "name": "COASY transfers an adenylyl group from ATP to PPANT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10514238", "map_id": "none", "name": "Phosphopantetheine conjugation of the ACP domain of FAS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10514230", "map_id": "P91871", "name": "fasn-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10514235", "map_id": "Q22856", "name": "AASDHPPT", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00012142", "map_id": "WBGene00012142", "name": "AASDHPPT", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10567381", "map_id": "none", "name": "SLC25A19 transports ThDP from cytosol to mitochondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space" }, { "id": "species_29480", "map_id": "CHEBI:58937", "name": "ThDP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10567378", "map_id": "A3QMB9", "name": "hpo-12", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "WBGene00016588", "map_id": "WBGene00016588", "name": "hpo-12", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10513701", "map_id": "none", "name": "2xTPK1:Mg2+ phosphorylates THMN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_196934", "map_id": "CHEBI:18385", "name": "THMN", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10513698", "map_id": "none", "name": "2xTPK1:Mg2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P30636", "map_id": "P30636", "name": "tpk-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00014027", "map_id": "WBGene00014027", "name": "tpk-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10514362", "map_id": "none", "name": "SLC19A2/3 transport extracellular THMN to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_199622", "map_id": "CHEBI:18385", "name": "THMN", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10514359", "map_id": "none", "name": "SLC19A2/3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10546096", "map_id": "none", "name": "HLCS biotinylates 6xMCCC1:6xMCCC2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10546090", "map_id": "none", "name": "6xMCCC1:6xMCCC2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_199207", "map_id": "CHEBI:15956", "name": "Btn", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10546094", "map_id": "none", "name": "6x(Btn-MCCC1:MCCC2)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10546065", "map_id": "Q9BI98", "name": "bpl-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00000259", "map_id": "WBGene00000259", "name": "bpl-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10546068", "map_id": "none", "name": "HLCS biotinylates 6x(PCCA:PCCB)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10546054", "map_id": "none", "name": "6x(PCCA:PCCB)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q20676", "map_id": "Q20676", "name": "pccb-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018701", "map_id": "WBGene00018701", "name": "pccb-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q19842", "map_id": "Q19842", "name": "pcca-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017864", "map_id": "WBGene00017864", "name": "pcca-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10546060", "map_id": "none", "name": "6x(Btn-PCCA:PCCB)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10546117", "map_id": "none", "name": "HLCS biotinylates ACACA:Mn2+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10546115", "map_id": "none", "name": "ACACA:2Mn2+", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10507413", "map_id": "none", "name": "Btn-ACACA:2Mn2+", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10549065", "map_id": "none", "name": "HLCS biotinylates ACACB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10549063", "map_id": "none", "name": "ACACB:2Mn2+", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "true" }, { "id": "species_10514575", "map_id": "none", "name": "Btn-ACACB:2Mn2+", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "true" }, { "id": "reaction_10546107", "map_id": "none", "name": "HLCS biotinylates PC:Mn2+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10546100", "map_id": "none", "name": "4x(PC:Mn2+)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "O17732", "map_id": "O17732", "name": "pyc-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004258", "map_id": "WBGene00004258", "name": "pyc-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10546105", "map_id": "none", "name": "4x(Btn-PC:Mn2+)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10547436", "map_id": "none", "name": "Cytoslic carboxylases translocate to mitochondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10547434", "map_id": "none", "name": "hCBXs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10546283", "map_id": "none", "name": "hCBXs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "reaction_10529569", "map_id": "none", "name": "Cyclisation of GTP to precursor Z", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_947537", "map_id": "CHEBI:59648", "name": "Precursor Z", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_947703", "map_id": "CHEBI:17319", "name": "dADE", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10529566", "map_id": "none", "name": "holo-MOCS1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q20624", "map_id": "Q20624", "name": "moc-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009885", "map_id": "WBGene00009885", "name": "moc-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10529522", "map_id": "none", "name": "Exchange of oxygen with sulfur in MoCo", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_947575", "map_id": "CHEBI:60102", "name": "sulfurated MoCo", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10529519", "map_id": "Q21657", "name": "mocs-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00010983", "map_id": "WBGene00010983", "name": "mocs-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10529557", "map_id": "none", "name": "Molybdenum ion transfer onto molybdopterin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_947561", "map_id": "CHEBI:36264", "name": "MoO4(2-)", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_947496", "map_id": "CHEBI:58698", "name": "MPT", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10529554", "map_id": "none", "name": "3xGPHN:3xMg2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "G5EGH2", "map_id": "G5EGH2", "name": "moc-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003384", "map_id": "WBGene00003384", "name": "moc-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10529545", "map_id": "none", "name": "PXLP-K258-NFS1 transfers sulfur from cysteine onto MOCS3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10529529", "map_id": "none", "name": "MOCS3:Zn2+ (red.)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "O44510", "map_id": "O44510", "name": "moc-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018357", "map_id": "WBGene00018357", "name": "moc-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10529534", "map_id": "none", "name": "MOCS3-S-S(1-):Zn2+", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10529542", "map_id": "none", "name": "PXLP-K258-NFS1-2 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "O61741", "map_id": "O61741", "name": "nfs-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00015021", "map_id": "WBGene00015021", "name": "nfs-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10513732", "map_id": "none", "name": "2xTRAP hydrolyzes FMN to RIB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_196931", "map_id": "CHEBI:17015", "name": "RIB", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10513729", "map_id": "none", "name": "2xTRAP", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "O01320", "map_id": "O01320", "name": "ACP5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008531", "map_id": "WBGene00008531", "name": "ACP5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10513749", "map_id": "none", "name": "2xENPP1 hydrolyzes FAD to FMN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29386", "map_id": "CHEBI:16238", "name": "FAD", "type": "inhibitor", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10513746", "map_id": "none", "name": "2xENPP1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "P90754", "map_id": "P90754", "name": "ENPP1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007755", "map_id": "WBGene00007755", "name": "ENPP1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P90755", "map_id": "P90755", "name": "ENPP1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10513722", "map_id": "none", "name": "FLAD1 phosphorylates FMN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10513719", "map_id": "Q22017", "name": "flad-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00011271", "map_id": "WBGene00011271", "name": "flad-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10546475", "map_id": "none", "name": "SLC52A1,2,3 transport RIB from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_3165253", "map_id": "CHEBI:17015", "name": "RIB", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10546472", "map_id": "none", "name": "SLC52A1,2,3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "G4SDH4", "map_id": "G4SDH4", "name": "rft-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021626", "map_id": "WBGene00021626", "name": "rft-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q3LFN0", "map_id": "Q3LFN0", "name": "rft-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00044637", "map_id": "WBGene00044637", "name": "rft-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10546433", "map_id": "none", "name": "MMACHC decyanates CNCbl", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_3149505", "map_id": "CHEBI:17439", "name": "CNCbl", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10546288", "map_id": "Q7Z144", "name": "cblc-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00022766", "map_id": "WBGene00022766", "name": "cblc-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_1130611", "map_id": "CHEBI:18407", "name": "HCN", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10546290", "map_id": "none", "name": "MMACHC:cob(II)alamin", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q7Z144", "map_id": "Q7Z144", "name": "cblc-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_3149479", "map_id": "CHEBI:16304", "name": "cob(II)alamin", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "reaction_10546436", "map_id": "none", "name": "MTR transfers CH3 group from MTHF to cob(I)alamin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10550725", "map_id": "none", "name": "ABCD4 may transport Cbl from lysosomal lumen to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_3000239", "map_id": "CHEBI:28911", "name": "Cbl", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_3000241", "map_id": "CHEBI:28911", "name": "Cbl", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10550722", "map_id": "F5GUC6", "name": "pmp-3", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "false" }, { "id": "WBGene00004060", "map_id": "WBGene00004060", "name": "pmp-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10546438", "map_id": "none", "name": "MMADHC targets transport of cytosolic cob(II)alamin to mitochondria", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10546415", "map_id": "none", "name": "MMACHC:MMADHC:cob(II)alamin", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9XWC9", "map_id": "Q9XWC9", "name": "MMADHC", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013577", "map_id": "WBGene00013577", "name": "MMADHC", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_3149564", "map_id": "CHEBI:16304", "name": "cob(II)alamin", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10546417", "map_id": "none", "name": "MMACHC:MMADHC", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10546504", "map_id": "none", "name": "cob(II)alamin binds to MTRR:MTR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10546425", "map_id": "none", "name": "MTRR:MTR", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10546427", "map_id": "none", "name": "MTRR:MTR(cob(II)alamin)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10546448", "map_id": "none", "name": "MMAB transfers adenosyl group from ATP to cob(I)alamin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_3159274", "map_id": "CHEBI:15266", "name": "PPP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_3159297", "map_id": "CHEBI:18408", "name": "AdoCbl", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10546445", "map_id": "none", "name": "3xMMAB", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q18218", "map_id": "Q18218", "name": "mmab-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016144", "map_id": "WBGene00016144", "name": "mmab-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10546450", "map_id": "none", "name": "MMAA:MUT binds AdoCbl", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10503659", "map_id": "none", "name": "2xMMAA:2xMUT", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q22111", "map_id": "Q22111", "name": "mmaa-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020169", "map_id": "WBGene00020169", "name": "mmaa-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q23381", "map_id": "Q23381", "name": "mmcm-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00014202", "map_id": "WBGene00014202", "name": "mmcm-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10503661", "map_id": "none", "name": "2xMMAA:2xMUT:AdoCbl", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "reaction_10503666", "map_id": "none", "name": "MUT isomerises L-MM-CoA to SUCC-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_71009", "map_id": "CHEBI:15465", "name": "L-MM-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10546419", "map_id": "none", "name": "cob(II)alamin dissociates from MMACHC:MMADHC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10546293", "map_id": "none", "name": "MMACHC reduces Cbl", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10546421", "map_id": "none", "name": "MMACHC:cob(II)alamin binds MMADHC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10546413", "map_id": "Q9XWC9", "name": "MMADHC", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10546296", "map_id": "none", "name": "ABCC1 transports cytosolic Cbl to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_3000125", "map_id": "CHEBI:28911", "name": "Cbl", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10517853", "map_id": "Q3S1M2", "name": "mrp-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "WBGene00003407", "map_id": "WBGene00003407", "name": "mrp-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10546430", "map_id": "none", "name": "MTRR reduces cob(II)alamin to meCbl", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10535154", "map_id": "none", "name": "BH2 binding can lead to eNOS uncoupling", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10535152", "map_id": "none", "name": "p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10534357", "map_id": "none", "name": "DHNTP is dephosphorylated by PTPS to PTHP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1474124", "map_id": "CHEBI:18372", "name": "DHNTP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_1475054", "map_id": "CHEBI:15266", "name": "PPP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_1474179", "map_id": "CHEBI:17804", "name": "PTHP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10534354", "map_id": "none", "name": "p-PTPS hexamer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "O02058", "map_id": "O02058", "name": "ptps-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00015010", "map_id": "WBGene00015010", "name": "ptps-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10534343", "map_id": "none", "name": "GCH1 reduces GTP to dihydroneopterin triphosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10534331", "map_id": "none", "name": "GCH1 decamer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q19980", "map_id": "Q19980", "name": "cat-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000298", "map_id": "WBGene00000298", "name": "cat-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10534341", "map_id": "none", "name": "2GCHFR:GCH1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "D6RYD9", "map_id": "D6RYD9", "name": "gfrp-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00044736", "map_id": "WBGene00044736", "name": "gfrp-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10534712", "map_id": "none", "name": "PTPS is phosphorylated by cGMP-dependant protein kinase II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10534700", "map_id": "none", "name": "PTPS hexamer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10534709", "map_id": "none", "name": "Homologues of PRKG2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10534346", "map_id": "none", "name": "GCHFR binds to GCH1 and negatively regulates its activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10534339", "map_id": "none", "name": "GCHFR pentamer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10520593", "map_id": "none", "name": "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_389545", "map_id": "CHEBI:151", "name": "ISCIT", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10520590", "map_id": "none", "name": "IDH1 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10552560", "map_id": "none", "name": "KCNK dimers transport K+ from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10552557", "map_id": "none", "name": "KCNK dimers", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10572199", "map_id": "none", "name": "FOXO4 binds ATXN3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10514278", "map_id": "O16850", "name": "daf-16", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10572197", "map_id": "none", "name": "FOXO4:ATXN3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10572203", "map_id": "none", "name": "FOXO1,FOXO3,FOXO4 bind p-2S-SMAD2/3:SMAD4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10572201", "map_id": "none", "name": "FOXO1,FOXO3,FOXO4:p-2S-SMAD2/3:SMAD4", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10572288", "map_id": "none", "name": "CREBBP binds FOXO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10572286", "map_id": "none", "name": "FOXO1:CREBBP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10572248", "map_id": "none", "name": "KAT2B,EP300 acetylate FOXO3 under oxidative stress", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10572243", "map_id": "O16850", "name": "daf-16", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10572245", "map_id": "none", "name": "KAT2B,(EP300)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_3785707", "map_id": "CHEBI:26523", "name": "ROS", "type": "catalyst", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10572251", "map_id": "none", "name": "SIRT1,SIRT3 deacetylate FOXO3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10572161", "map_id": "none", "name": "14-3-3 proteins bind AKT-phosphorylated FOXO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10572157", "map_id": "none", "name": "YWHAZ dimer,YWHAQ dimer,YWHAG dimer,YWHAB dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10572159", "map_id": "none", "name": "p-T24,S256,S319-FOXO1:YWHAZ,YWHAQ,YWHAG,YWHAB", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10572167", "map_id": "none", "name": "14-3-3 proteins bind AKT-phosphorylated FOXO3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10572163", "map_id": "none", "name": "YWHAZ dimer,YWHAQ dimer,SFN dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10572165", "map_id": "none", "name": "p-T32,S253,S315-FOXO3:YWHAZ,YWHAQ,SFN", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10572155", "map_id": "none", "name": "AKT-phosphorylated FOXO1,FOXO3,FOXO4 translocate to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10572171", "map_id": "none", "name": "14-3-3 proteins bind AKT-phosphorylated FOXO4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10572153", "map_id": "O16850", "name": "phospho-daf-16", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10572169", "map_id": "none", "name": "p-T32,S197,S262-FOXO4:YWHAZ dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10569079", "map_id": "none", "name": "EP300 acetylates RUNX3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10569066", "map_id": "none", "name": "RUNX3:CBFB:EP300", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10569076", "map_id": "none", "name": "Ac-K94,K171-RUNX3:CBFB:EP300", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10569160", "map_id": "none", "name": "CCND1 recruits HDAC4 to RUNX3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10549372", "map_id": "O17323", "name": "hda-4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10569156", "map_id": "none", "name": "Ac-K94,K171-RUNX3:CBFB:BRD2:CCND1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "O76561", "map_id": "O76561", "name": "BRD2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017423", "map_id": "WBGene00017423", "name": "BRD2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q95Y80", "map_id": "Q95Y80", "name": "bet-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022473", "map_id": "WBGene00022473", "name": "bet-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A0K3AWB8", "map_id": "A0A0K3AWB8", "name": "bet-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "F57C7.1d", "map_id": "F57C7.1d", "name": "bet-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10569158", "map_id": "none", "name": "Ac-K94,K171-RUNX3:CBFB:BRD2:CCND1:HDAC4", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10569165", "map_id": "none", "name": "HDAC4 deacetylates RUNX3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10569098", "map_id": "none", "name": "BRD2 homodimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10569162", "map_id": "none", "name": "RUNX3:CBFB:CCND1:HDAC4", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10569068", "map_id": "none", "name": "RUNX3 binds EP300", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10569102", "map_id": "none", "name": "Acetylated RUNX3 binds to BRD2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10569100", "map_id": "none", "name": "Ac-K94,K171-RUNX3:CBFB:EP300:BRD2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10549046", "map_id": "none", "name": "HRAS:GTP", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10570708", "map_id": "none", "name": "PPM1D dephosphorylates RUNX2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10570700", "map_id": "none", "name": "p-S432-RUNX2:CBFB", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10567753", "map_id": "none", "name": "RUNX2:CBFB", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10570705", "map_id": "Q95XK4", "name": "ppm-1.d", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00021856", "map_id": "WBGene00021856", "name": "ppm-1.d", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10568512", "map_id": "none", "name": "SCF(SKP2) polyubiquitinates RUNX2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10568502", "map_id": "none", "name": "RUNX2:SCF(SKP2)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10568507", "map_id": "G5EFQ5", "name": "rnt-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10568514", "map_id": "none", "name": "26S proteasome degrades PolyUb-RUNX2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10570789", "map_id": "none", "name": "STUB1 polyubiquitinates RUNX2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10570782", "map_id": "none", "name": "RUNX2:STUB1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10570784", "map_id": "G5EFQ5", "name": "rnt-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10570791", "map_id": "none", "name": "RUNX2 binds STUB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10570778", "map_id": "G5EFQ5", "name": "rnt-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10568504", "map_id": "none", "name": "SCF(SKP2) complex binds RUNX2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10567747", "map_id": "G5EFQ5", "name": "rnt-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10568390", "map_id": "none", "name": "RMB14 binds RUNX2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10568386", "map_id": "Q10667", "name": "rnp-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00004384", "map_id": "WBGene00004384", "name": "rnp-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10568388", "map_id": "none", "name": "RUNX2:RBM14", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q10667", "map_id": "Q10667", "name": "rnp-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10567757", "map_id": "none", "name": "RUNX2 binds SMAD1 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10567751", "map_id": "none", "name": "p-2S-SMAD1:p-2S-SMAD1:SMAD4", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10567755", "map_id": "none", "name": "RUNX2:CBFB:p-2S-SMAD1:p-2S-SMAD1:SMAD4", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10570776", "map_id": "none", "name": "CDK1 phosphorylates RUNX2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10570692", "map_id": "none", "name": "p-S451-RUNX2:CBFB", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10569938", "map_id": "none", "name": "E2F6:TFDP1:EPC1 binds the PRC2 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10569934", "map_id": "none", "name": "E2F6:TFDP1:EPC1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "G5EC14", "map_id": "G5EC14", "name": "epc-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007030", "map_id": "WBGene00007030", "name": "epc-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10569936", "map_id": "none", "name": "E2F6:TFDP1:EPC1:PRC2 (EZH2) core", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10569925", "map_id": "none", "name": "E2F6 binds TFDP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10532095", "map_id": "Q22703", "name": "dpl-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10569808", "map_id": "A5HWA8", "name": "efl-2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10569923", "map_id": "none", "name": "E2F6:TFDP2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10569812", "map_id": "none", "name": "E2F6 binds TFDP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10532093", "map_id": "Q22703", "name": "dpl-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10569810", "map_id": "none", "name": "E2F6:TFDP1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10569940", "map_id": "none", "name": "E2F6:TFDP1 binds EPC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10569932", "map_id": "G5EC14", "name": "epc-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10570682", "map_id": "none", "name": "CHEK1 phosphorylates E2F6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10570680", "map_id": "A5HWA8", "name": "phospho-efl-2", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10569855", "map_id": "none", "name": "E2F6:TFDP1 binds to MGA:MAX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10569851", "map_id": "none", "name": "MGA:MAX", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q23622", "map_id": "Q23622", "name": "tbx-36", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006555", "map_id": "WBGene00006555", "name": "tbx-36", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8TA81", "map_id": "Q8TA81", "name": "MGA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022695", "map_id": "WBGene00022695", "name": "MGA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q95PX3", "map_id": "Q95PX3", "name": "tbx-7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006544", "map_id": "WBGene00006544", "name": "tbx-7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9N2K7", "map_id": "Q9N2K7", "name": "tbx-42", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006549", "map_id": "WBGene00006549", "name": "tbx-42", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9NA55", "map_id": "Q9NA55", "name": "tbx-40", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006559", "map_id": "WBGene00006559", "name": "tbx-40", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9NA56", "map_id": "Q9NA56", "name": "tbx-39", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006558", "map_id": "WBGene00006558", "name": "tbx-39", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9NAH2", "map_id": "Q9NAH2", "name": "tbx-34", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006553", "map_id": "WBGene00006553", "name": "tbx-34", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9TZL0", "map_id": "Q9TZL0", "name": "tbx-31", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006550", "map_id": "WBGene00006550", "name": "tbx-31", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9U2C9", "map_id": "Q9U2C9", "name": "tbx-37", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006556", "map_id": "WBGene00006556", "name": "tbx-37", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XVD5", "map_id": "Q9XVD5", "name": "tbx-38", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006557", "map_id": "WBGene00006557", "name": "tbx-38", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O45291", "map_id": "O45291", "name": "tbx-33", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006552", "map_id": "WBGene00006552", "name": "tbx-33", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O61764", "map_id": "O61764", "name": "tbx-32", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006551", "map_id": "WBGene00006551", "name": "tbx-32", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q20257", "map_id": "Q20257", "name": "tbx-11", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006547", "map_id": "WBGene00006547", "name": "tbx-11", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q22289", "map_id": "Q22289", "name": "tbx-9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006546", "map_id": "WBGene00006546", "name": "tbx-9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q22292", "map_id": "Q22292", "name": "tbx-8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006545", "map_id": "WBGene00006545", "name": "tbx-8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q18711", "map_id": "Q18711", "name": "mxl-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003511", "map_id": "WBGene00003511", "name": "mxl-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10569853", "map_id": "none", "name": "E2F6:TFDP1:MGA:MAX", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10565458", "map_id": "none", "name": "VENTX disrupts binding of CTNNB1 (beta-catenin) to TCF4 or LEF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10565454", "map_id": "none", "name": "CTNNB1:TCF7L2,LEF1:CCND1 Gene", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10565450", "map_id": "Q19937", "name": "tab-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00006380", "map_id": "WBGene00006380", "name": "tab-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10565456", "map_id": "none", "name": "VENTX:TCF4,LEF1:CCND1 Gene", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q19937", "map_id": "Q19937", "name": "tab-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10567123", "map_id": "none", "name": "YAP1 binds TEAD4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10542193", "map_id": "Q19849", "name": "egl-44", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10567121", "map_id": "none", "name": "TEAD4:YAP1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10542197", "map_id": "none", "name": "WWTR1 (TAZ) binds TEAD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10542183", "map_id": "Q19849", "name": "egl-44", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10542195", "map_id": "none", "name": "TEAD:WWTR1(TAZ)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10567127", "map_id": "none", "name": "YAP1 binds TEAD3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10542191", "map_id": "Q19849", "name": "egl-44", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10567125", "map_id": "none", "name": "TEAD3:YAP1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10542187", "map_id": "none", "name": "YAP1 binds TEAD1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10542283", "map_id": "none", "name": "WWTR1 (TAZ), TBX5, and PCAF form a complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10542202", "map_id": "Q9N3S7", "name": "pcaf-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10542279", "map_id": "none", "name": "Homologues of TBX5", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10542281", "map_id": "none", "name": "TBX5:WWTR1:PCAF", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10567119", "map_id": "none", "name": "YAP1 binds TEAD2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10542189", "map_id": "Q19849", "name": "egl-44", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10567117", "map_id": "none", "name": "TEAD2:YAP1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10567590", "map_id": "none", "name": "RUNX1 binds FOXP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10567586", "map_id": "Q86MF0", "name": "fkh-7", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00001439", "map_id": "WBGene00001439", "name": "fkh-7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10567588", "map_id": "none", "name": "RUNX1:CBFB:FOXP3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q86MF0", "map_id": "Q86MF0", "name": "fkh-7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10568465", "map_id": "none", "name": "RUNX1 binds PAX5 (BSAP)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10568461", "map_id": "none", "name": "Homologues of PAX5", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "G5ED14", "map_id": "G5ED14", "name": "egl-38", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001204", "map_id": "WBGene00001204", "name": "egl-38", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EDS1", "map_id": "G5EDS1", "name": "vab-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006870", "map_id": "WBGene00006870", "name": "vab-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q21263", "map_id": "Q21263", "name": "pax-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003938", "map_id": "WBGene00003938", "name": "pax-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10568463", "map_id": "none", "name": "RUNX1:CBFB:PAX5", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10568444", "map_id": "none", "name": "RUNX1 binds ELF2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10568440", "map_id": "H2KYY1", "name": "elf-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10568442", "map_id": "none", "name": "RUNX1:CBFB:ELF2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10568259", "map_id": "none", "name": "PRMT6 arginine methylates H3K4me2-Nucleosome at the THBS1 gene promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10568254", "map_id": "none", "name": "RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:THBS1 gene:H3K4me2-Nucleosome", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "A5JYW9", "map_id": "A5JYW9", "name": "sin-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004117", "map_id": "WBGene00004117", "name": "sin-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10568256", "map_id": "none", "name": "RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:THBS1B gene:H3K4me2,H3R2me2a-Nucleosome", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10568275", "map_id": "none", "name": "PRMT6 arginine methylates H3K4me2-Nucleosome at the MIR27A gene promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10568270", "map_id": "none", "name": "RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:MIR27A gene:H3K4me2-Nucleosome", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10568272", "map_id": "none", "name": "RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:MIR27A gene:H3K4me2,H3R2me2a-Nucleosome", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10568130", "map_id": "none", "name": "PRMT1 arginine-methylates RUNX1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10568121", "map_id": "none", "name": "RUNX1:CBFB:PRMT1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10568127", "map_id": "none", "name": "MeR206,MeR210-RUNX1:CBFB:PRMT1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10568132", "map_id": "none", "name": "RUNX1 binds PRMT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10568196", "map_id": "none", "name": "Core MLL complex methylates H3K4Me2-Nucleosome at the ITGA2B gene promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10568187", "map_id": "none", "name": "H3K4me2-Nucleosome:ITGA2B gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10568193", "map_id": "none", "name": "H3K4me3-Nucleosome:ITGA2B gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10568212", "map_id": "none", "name": "PRMT6 arginine methylates H3K4me2-Nucleosome at the ITGA2B gene promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10568198", "map_id": "none", "name": "RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:ITGA2B gene:H3K4me2-Nucleosome", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10568209", "map_id": "none", "name": "RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:ITGA2B gene:H3K4me2,H3R2me2a-Nucleosome", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10568228", "map_id": "none", "name": "Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10568223", "map_id": "none", "name": "H3K4me2-Nucleosome:GP1BA gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10568225", "map_id": "none", "name": "H3K4me3-Nucleosome:GP1BA gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10568221", "map_id": "none", "name": "PRMT6 arginine methylates H3K4me2-Nucleosome at the GP1BA gene promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10568216", "map_id": "none", "name": "RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:GP1BA gene:H3K4me2-Nucleosome", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10568218", "map_id": "none", "name": "RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:GP1BA gene:H3K4me2,H3R2me2a-Nucleosome", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10568252", "map_id": "none", "name": "Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10568247", "map_id": "none", "name": "H3K4me2-Nucleosome:THBS1 gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10568249", "map_id": "none", "name": "H3K4me3-Nucleosome:THBS1 gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10568268", "map_id": "none", "name": "Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10568263", "map_id": "none", "name": "H3K4me2-Nucleosome:MIR27A gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10568265", "map_id": "none", "name": "H3K4me3-Nucleosome:MIR27A gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10567792", "map_id": "none", "name": "HIPK2 phosphorylates RUNX1 and EP300", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10567776", "map_id": "none", "name": "RUNX1:CBFB:EP300", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10567789", "map_id": "none", "name": "p-S249,S273,T276-RUNX1:CBFB:p-S,T-EP300", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10567794", "map_id": "none", "name": "HIPK2 phosphorylates RUNX1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10567787", "map_id": "none", "name": "p-S249,S273,T276-RUNX1:CBFB", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10567796", "map_id": "none", "name": "RUNX1:CBFB binds EP300", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10568377", "map_id": "none", "name": "RUNX1 binds the SWI/SNF complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10546652", "map_id": "none", "name": "SWI/SNF chromatin remodelling complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "H8ESF3", "map_id": "H8ESF3", "name": "swsn-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004203", "map_id": "WBGene00004203", "name": "swsn-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q21831", "map_id": "Q21831", "name": "snfc-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011111", "map_id": "WBGene00011111", "name": "snfc-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EF53", "map_id": "G5EF53", "name": "swsn-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004204", "map_id": "WBGene00004204", "name": "swsn-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P91094", "map_id": "P91094", "name": "pqn-15", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004106", "map_id": "WBGene00004106", "name": "pqn-15", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10568375", "map_id": "none", "name": "RUNX1:CBFB:SWI/SNF", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10570134", "map_id": "none", "name": "RUNX1 binds YAP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10570132", "map_id": "none", "name": "RUNX1:CBFB:YAP1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10555896", "map_id": "P03949", "name": "phospho-abl-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10570141", "map_id": "none", "name": "ABL1 phosphorylates YAP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10570138", "map_id": "Q19404", "name": "phospho-yap-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10568381", "map_id": "none", "name": "RUNX1:CBFB binds CREBBP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10568379", "map_id": "none", "name": "RUNX1:CBFB:CREBBP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10552368", "map_id": "none", "name": "Formation of MSH1:PMS2 Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10551625", "map_id": "G5EFG5", "name": "pms-2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00004064", "map_id": "WBGene00004064", "name": "pms-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10551620", "map_id": "Q9XU10", "name": "mlh-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00003373", "map_id": "WBGene00003373", "name": "mlh-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10551627", "map_id": "none", "name": "MLH1:PMS2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9XU10", "map_id": "Q9XU10", "name": "mlh-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EFG5", "map_id": "G5EFG5", "name": "pms-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10551667", "map_id": "none", "name": "EXO1 interacts with MSH2:MSH6 (MutSalpha) and MLH1:PMS2 (MutLalpha)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10551663", "map_id": "O62245", "name": "exo-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00009731", "map_id": "WBGene00009731", "name": "exo-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10551647", "map_id": "none", "name": "MLH1:PMS2:MSH2:MSH6:ATP:PCNA:DNA containing 1-2 base mismatch and single strand incision", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9TXR4", "map_id": "Q9TXR4", "name": "msh-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003418", "map_id": "WBGene00003418", "name": "msh-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9N3T8", "map_id": "Q9N3T8", "name": "msh-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003422", "map_id": "WBGene00003422", "name": "msh-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10551665", "map_id": "none", "name": "EXO1:MLH1:PMS2:MSH2:MSH6:ATP:PCNA:DNA containing 1-2 base mismatch and single strand incision", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "O62245", "map_id": "O62245", "name": "exo-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10551650", "map_id": "none", "name": "MLH1:PMS2 makes single strand incision near 1-2 base mismatch", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10551643", "map_id": "none", "name": "MLH1:PMS2:MSH2:MSH6:ATP:PCNA:DNA containing 1-2 base mismatch", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10551669", "map_id": "none", "name": "MSH2:MSH6 exchanges ADP for ATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10551654", "map_id": "none", "name": "MSH2:MSH6:ADP:DNA containing 1-2 base mismatch", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10551641", "map_id": "none", "name": "MSH2:MSH6:ATP:DNA containing 1-2 base mismatch", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10551656", "map_id": "none", "name": "MSH2:MSH6 binds 1 base mismatch or 1-2 base insertion/deletion loop", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10551652", "map_id": "none", "name": "MSH2:MSH6:ADP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_5358514", "map_id": "none", "name": "DNA containing mismatch or 1-2 base IDL", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10551645", "map_id": "none", "name": "MSH2:MSH6 recruits MLH1:PMS2 to mismatch and interacts with PCNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10552366", "map_id": "none", "name": "Formation of MSH2:MSH6 Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10551637", "map_id": "Q9N3T8", "name": "msh-6", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10551632", "map_id": "Q9TXR4", "name": "msh-2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10521473", "map_id": "none", "name": "Phosphorylation of CRMPs by GSK3beta", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10521396", "map_id": "none", "name": "Sema3A:Nrp-1:PlexinA:Fyn:Cdk5:pCRMP's", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "G5ECH7", "map_id": "G5ECH7", "name": "phospho-cdk-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000407", "map_id": "WBGene00000407", "name": "phospho-cdk-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q22695", "map_id": "Q22695", "name": "cdka-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011955", "map_id": "WBGene00011955", "name": "cdka-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10521470", "map_id": "none", "name": "Sema3A:Nrp-1:PlexinA:Fyn:Cdk5:pCRMP's", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10521399", "map_id": "none", "name": "Phosphorylation of CRMPs by Cdk5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10521323", "map_id": "none", "name": "CRMP's tetramers", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10521345", "map_id": "none", "name": "Sema3A:Nrp-1:PlexinA:Fyn:pCdk5", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10521435", "map_id": "none", "name": "Tyrosine phosphorylation of CRMPs by Fes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10521204", "map_id": "none", "name": "Sema3A:NRP-1:pPlexin-A:Fyn:Fes", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "O01325", "map_id": "O01325", "name": "FER", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009160", "map_id": "WBGene00009160", "name": "FER", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10521432", "map_id": "none", "name": "Sema3A:NP-1:Plexin-A:Fes:CRMP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10516270", "map_id": "O01325", "name": "FER", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10503744", "map_id": "none", "name": "q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_71129", "map_id": "CHEBI:20680", "name": "qDHB", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10503741", "map_id": "none", "name": "QDPR dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9XVJ3", "map_id": "Q9XVJ3", "name": "qdpr-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011398", "map_id": "WBGene00011398", "name": "qdpr-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10503734", "map_id": "none", "name": "PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10503731", "map_id": "none", "name": "PAH:Fe2+ tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P90925", "map_id": "P90925", "name": "pah-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000240", "map_id": "WBGene00000240", "name": "pah-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10528409", "map_id": "none", "name": "phenylalanine + pyruvate => 3-(indol-3-yl)pyruvate + alanine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_893599", "map_id": "CHEBI:29750", "name": "3IN-PYRA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10503754", "map_id": "none", "name": "4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10503751", "map_id": "none", "name": "PCBD1 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9TZH6", "map_id": "Q9TZH6", "name": "pcbd-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020397", "map_id": "WBGene00020397", "name": "pcbd-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10507618", "map_id": "none", "name": "2 H2O2 => O2 + 2 H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_10507615", "map_id": "none", "name": "CAT tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "true" }, { "id": "reaction_10548068", "map_id": "none", "name": "SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space" }, { "id": "species_3341308", "map_id": "CHEBI:18421", "name": "O2-", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "false" }, { "id": "species_189481", "map_id": "CHEBI:16240", "name": "H2O2", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "false" }, { "id": "species_189461", "map_id": "CHEBI:15379", "name": "O2", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "false" }, { "id": "species_10548065", "map_id": "none", "name": "SOD1 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "true" }, { "id": "P34697", "map_id": "P34697", "name": "sod-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004930", "map_id": "WBGene00004930", "name": "sod-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q27538", "map_id": "Q27538", "name": "sod-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007036", "map_id": "WBGene00007036", "name": "sod-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10547432", "map_id": "none", "name": "GSR catalyzes glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_1655882", "map_id": "CHEBI:17858", "name": "GSSG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10547429", "map_id": "none", "name": "GSR dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "reaction_10549770", "map_id": "none", "name": "Secretion of SOD3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "species_10549768", "map_id": "none", "name": "SOD3 tetramer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "species_10547194", "map_id": "none", "name": "SOD3 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10547467", "map_id": "none", "name": "PRDX6:GSTP1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10547464", "map_id": "none", "name": "PRDX6:GSTP1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10547212", "map_id": "none", "name": "SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1222424", "map_id": "CHEBI:18421", "name": "O2.-", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10547209", "map_id": "none", "name": "2xHC-SOD1:Zn2+:Cu2+ dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10547438", "map_id": "none", "name": "Superoxide reduces cytochrome c", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane" }, { "id": "species_10510159", "map_id": "none", "name": "Cytochrome c (oxidised)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "CHEBI:38574", "map_id": "CHEBI:38574", "name": "CHEBI:38574", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10510157", "map_id": "none", "name": "Cytochrome c (reduced)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "CHEBI:38573", "map_id": "CHEBI:38573", "name": "CHEBI:38573", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10547186", "map_id": "none", "name": "SOD2 catalyzes 2H+ + 2O2.- => O2 + H2O2 (mitochondrial matrix)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_3299683", "map_id": "CHEBI:18421", "name": "O2.-", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10547183", "map_id": "none", "name": "SOD2 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "P31161", "map_id": "P31161", "name": "sod-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004931", "map_id": "WBGene00004931", "name": "sod-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10547411", "map_id": "none", "name": "PRDX3,5 catalyze TXN2 reduced + H2O2 => TXN2 oxidized + 2H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10547408", "map_id": "none", "name": "PRDX3 dodecamer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q21824", "map_id": "Q21824", "name": "prdx-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011110", "map_id": "WBGene00011110", "name": "prdx-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10557597", "map_id": "none", "name": "NUDT2 hydrolyses GP4G to GTP, GMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_5696199", "map_id": "CHEBI:15883", "name": "GP4G", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_5696194", "map_id": "CHEBI:17345", "name": "GMP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10557594", "map_id": "Q9U2M7", "name": "ndx-4", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "WBGene00003581", "map_id": "WBGene00003581", "name": "ndx-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10547197", "map_id": "none", "name": "SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_3299686", "map_id": "CHEBI:18421", "name": "O2.-", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_352327", "map_id": "CHEBI:15379", "name": "O2", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10547423", "map_id": "none", "name": "TXNRD2 catalyzes the reduction of TXN2 by NADPH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10547420", "map_id": "none", "name": "TXNRD2 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "P30635", "map_id": "P30635", "name": "trxr-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00014028", "map_id": "WBGene00014028", "name": "trxr-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10502803", "map_id": "none", "name": "Phosphorylation of Cdc25A at Ser-123 by Chk2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10502800", "map_id": "Q9U1Y5", "name": "phospho-chk-2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00000499", "map_id": "WBGene00000499", "name": "phospho-chk-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10502779", "map_id": "none", "name": "Proteolytic degradation of ubiquitinated-Cdc25A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10502777", "map_id": "none", "name": "Ub-p-S123-CDC25A", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10557688", "map_id": "none", "name": "PARP1 or PARP2 PARylates DDB2 and autoPARylates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10557686", "map_id": "none", "name": "Ub:XPC:RAD23:CETN2:Distorted dsDNA:UV-DDB:PARP1,PARP2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10556156", "map_id": "none", "name": "Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10556733", "map_id": "none", "name": "XPC binds RAD23 and CETN2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10556067", "map_id": "Q23451", "name": "rad-23", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10549280", "map_id": "P30644", "name": "CETN2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10556731", "map_id": "none", "name": "XPC:RAD23:CETN2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10556781", "map_id": "none", "name": "XPC:RAD23:CETN2 and UV-DDB bind distorted dsDNA site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10556777", "map_id": "none", "name": "UV-DDB:COP9 Signalosome", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9GS00", "map_id": "Q9GS00", "name": "csn-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000813", "map_id": "WBGene00000813", "name": "csn-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9N359", "map_id": "Q9N359", "name": "csn-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000816", "map_id": "WBGene00000816", "name": "csn-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P91001", "map_id": "P91001", "name": "csn-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000817", "map_id": "WBGene00000817", "name": "csn-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O01422", "map_id": "O01422", "name": "csn-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000814", "map_id": "WBGene00000814", "name": "csn-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9N425", "map_id": "Q9N425", "name": "csn-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000815", "map_id": "WBGene00000815", "name": "csn-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q95PZ0", "map_id": "Q95PZ0", "name": "csn-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000818", "map_id": "WBGene00000818", "name": "csn-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_5688114", "map_id": "none", "name": "Distorted dsDNA", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10556779", "map_id": "none", "name": "XPC:RAD23:CETN2:Distorted dsDNA:UV-DDB", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10556775", "map_id": "none", "name": "COP9 signalosome", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10557965", "map_id": "none", "name": "UV-DDB ubiquitinates XPC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10557684", "map_id": "none", "name": "Ub:XPC:RAD23:CETN2:Distorted dsDNA:UV-DDB", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10537696", "map_id": "none", "name": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_994170", "map_id": "CHEBI:16783", "name": "I(1,3,4,5)P4", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_994123", "map_id": "CHEBI:18228", "name": "I(1,3,4)P3", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10537691", "map_id": "O17590", "name": "ocrl-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10537745", "map_id": "none", "name": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10537742", "map_id": "none", "name": "PLCdegh", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "G5EFI8", "map_id": "G5EFI8", "name": "plc-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004036", "map_id": "WBGene00004036", "name": "plc-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10537729", "map_id": "none", "name": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10537603", "map_id": "none", "name": "INPP5(4)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "O17590", "map_id": "O17590", "name": "ocrl-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34370", "map_id": "P34370", "name": "cil-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00086546", "map_id": "WBGene00086546", "name": "cil-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5ECL2", "map_id": "G5ECL2", "name": "unc-26", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006763", "map_id": "WBGene00006763", "name": "unc-26", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10537619", "map_id": "none", "name": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10537616", "map_id": "none", "name": "PLCB4:Ca2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10537513", "map_id": "none", "name": "I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by ITPKA/B/C in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10537510", "map_id": "none", "name": "ITPKA/B/C", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q95Q62", "map_id": "Q95Q62", "name": "lfe-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002979", "map_id": "WBGene00002979", "name": "lfe-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10537723", "map_id": "none", "name": "PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_2023856", "map_id": "CHEBI:18348", "name": "PI(4,5)P2", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10537720", "map_id": "none", "name": "PLD4:Ca2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q8I4C7", "map_id": "Q8I4C7", "name": "PLD4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020256", "map_id": "WBGene00020256", "name": "PLD4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "H2KZ05", "map_id": "H2KZ05", "name": "PLD4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O17405", "map_id": "O17405", "name": "PLD3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017316", "map_id": "WBGene00017316", "name": "PLD3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q19056", "map_id": "Q19056", "name": "PLD4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10537677", "map_id": "none", "name": "I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10537674", "map_id": "none", "name": "PTEN:Mg2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10572147", "map_id": "none", "name": "Autocleavage of ADGRG6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10572138", "map_id": "Q19930", "name": "mth-2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10572144", "map_id": "none", "name": "ADGRG6-CTF:ADGRG6-NTF", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10572149", "map_id": "none", "name": "ADGRG heterodimer translocates to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10519185", "map_id": "none", "name": "NCAM1 binds to ATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_114570", "map_id": "CHEBI:30616", "name": "ATP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10519183", "map_id": "none", "name": "NCAM-1:ATP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10519181", "map_id": "none", "name": "Interaction of NCAM1 with collagens", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10519177", "map_id": "none", "name": "Collagens", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10519179", "map_id": "none", "name": "NCAM-1:Collagen complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10520993", "map_id": "none", "name": "NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10520988", "map_id": "none", "name": "Grb2:Sos:pFAK bound to NCAM1:pFyn", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10520984", "map_id": "none", "name": "Recruitment of Grb2 to pFAK:NCAM1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10520978", "map_id": "none", "name": "Multiple phosphorylated FAK bound to NCAM:pFyn", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10520982", "map_id": "none", "name": "Grb2:pFAK bound to NCAM1:pFyn", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10520990", "map_id": "none", "name": "SOS binds Grb2 bound to pFAK:NCAM1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10570819", "map_id": "none", "name": "SLITs bind keratan sulfate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_2299699", "map_id": "CHEBI:60924", "name": "Keratan sulfate", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10570817", "map_id": "none", "name": "SLIT2,(SLIT3):Keratan sulfate", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10523182", "map_id": "none", "name": "Glypican-1 (GPC1) binds SLIT2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10523178", "map_id": "none", "name": "GPC1:HSPG", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10523180", "map_id": "none", "name": "SLIT2,SLIT2 cleavage fragments:GPC1:HSPG", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10571295", "map_id": "none", "name": "ROBOs bind keratan sulfate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10571293", "map_id": "none", "name": "ROBO1,ROBO2:Keratan sulfate", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10521289", "map_id": "none", "name": "Autophosphorylation of PAK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10521208", "map_id": "none", "name": "Sema3A:Nrp-1:PlexinA:Rac1-GTP:PAK", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10521286", "map_id": "none", "name": "Sema3A:Nrp-1:PlexinA:Rac1-GTP:pPAK", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10521210", "map_id": "none", "name": "Activation of PAK by Rac1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10521206", "map_id": "none", "name": "Sema3A:Nrp-1:pPlexinA:Fyn:Fes:Rac-1-GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10521249", "map_id": "none", "name": "Sema3A binds Nrp-1 bound to PlexinA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10521243", "map_id": "none", "name": "NRP1:PlexinA1-4:FARP2:FYN", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10521174", "map_id": "none", "name": "Sema3A dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10521247", "map_id": "none", "name": "Sema3A:Nrp-1:Plexin A:Fyn", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10521239", "map_id": "O17905", "name": "frm-3", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10521260", "map_id": "none", "name": "Inhibition of integrin activation by sequestering PIP5KIgamma", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10521256", "map_id": "none", "name": "PIP5K1gamma:Talin-1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10521258", "map_id": "none", "name": "FARP2:PIP5KIgamma", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10521608", "map_id": "none", "name": "Activation of Rho by LARG and PDZ-RhoGEF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10521605", "map_id": "none", "name": "SEMA4D:ERBB2:p-Y-PLXNB1:RND1:ARHGEF11,ARHGEF12", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10521610", "map_id": "none", "name": "LARG and PDZ-RhoGEF binds to Plexin-B1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10521603", "map_id": "none", "name": "ARHGEF11,ARHGEF12", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10521601", "map_id": "none", "name": "SEMA4D:ERBB2:p-Y-PLXNB1:RND1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10518622", "map_id": "none", "name": "SEMA4D interacts with Plexin-B1:ErbB2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10518607", "map_id": "none", "name": "Plexin-B1:ErbB2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10518591", "map_id": "none", "name": "SEMA4D dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10518619", "map_id": "none", "name": "SEMA4D:ERBB2:p-Y-PLXNB1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10521585", "map_id": "none", "name": "Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10521574", "map_id": "none", "name": "R-Ras-GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "G5EBK8", "map_id": "G5EBK8", "name": "ras-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004310", "map_id": "WBGene00004310", "name": "ras-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10521576", "map_id": "none", "name": "R-Ras-GDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10521582", "map_id": "none", "name": "SEMA4D:MET:p-Y-PLXNB1:RND1:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10521963", "map_id": "none", "name": "SEMA4D interacts with Plexin-B1:Met", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10521960", "map_id": "none", "name": "Plexin-B1:Met", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10521546", "map_id": "none", "name": "SEMA4D:MET:p-Y-PLXNB1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10521595", "map_id": "none", "name": "Inactivation of Rho-GTP by p190RhoGAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10521592", "map_id": "none", "name": "SEMA4D:MET:p-Y-PLXNB1:RND1:GTP:ARHGAP35", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10521597", "map_id": "none", "name": "p190RhoGAP binds Plexin-B1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10521550", "map_id": "none", "name": "Active Rac1 interacts with Plexin-B1:Sema4D", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10521548", "map_id": "none", "name": "Sema4D:pPlexin-B1:Met:RAC1-GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10518688", "map_id": "none", "name": "DCC interaction with Ezrin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10518684", "map_id": "none", "name": "p-T567-EZR:PIP2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10518486", "map_id": "G5EF96", "name": "unc-40", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10518686", "map_id": "none", "name": "DCC:p-T567-EZR:PIP2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "G5EF96", "map_id": "G5EF96", "name": "phospho-unc-40", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "phospho-unc-40", "map_id": "phospho-unc-40", "name": "phospho-unc-40", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10518706", "map_id": "none", "name": "DCC interaction with SIAH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10518702", "map_id": "Q965X6", "name": "siah-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00021369", "map_id": "WBGene00021369", "name": "siah-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10518499", "map_id": "none", "name": "DCC:NTN1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10518704", "map_id": "none", "name": "NTN1:DCC:SIAH2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q965X6", "map_id": "Q965X6", "name": "siah-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10518691", "map_id": "none", "name": "Phosphorylation and activation of Ezrin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10518677", "map_id": "none", "name": "EZR:PIP2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10515209", "map_id": "P34722", "name": "phospho-tpa-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10518533", "map_id": "none", "name": "DCC interacting NCK-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10518529", "map_id": "none", "name": "NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10518531", "map_id": "none", "name": "NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10521893", "map_id": "none", "name": "Activation of Cdc42", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10520579", "map_id": "none", "name": "CDC42:GDP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10521888", "map_id": "none", "name": "NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10521890", "map_id": "none", "name": "NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO:CDC42:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10518503", "map_id": "none", "name": "Netrin-1 induced DCC clustering", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10518501", "map_id": "none", "name": "NTN1:DCC oligomer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10518505", "map_id": "none", "name": "DCC interaction with Netrin-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10518497", "map_id": "P34710", "name": "unc-6", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10521899", "map_id": "none", "name": "RhoGTPase GEF's recruited to DCC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10521886", "map_id": "G5EEN3", "name": "ced-5", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10521901", "map_id": "none", "name": "Recruitment of Src and Fyn to DCC:FADK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10518527", "map_id": "none", "name": "MyrG-p-Y419-SRC,MyrG-p-Y420-FYN", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10518770", "map_id": "none", "name": "NTN1:DCC oligomer:p-Y397-PTK2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10518772", "map_id": "none", "name": "NTN1:DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10518781", "map_id": "none", "name": "Phosphorylation of DCC by Fyn", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10519264", "map_id": "none", "name": "DSCAM/DSCAML1 homodimerization", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10519260", "map_id": "none", "name": "DSCAM, DSCAML1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10519262", "map_id": "none", "name": "DSCAM/DSCAML1 homodimers", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10526129", "map_id": "none", "name": "Activation of JNK by DSCAM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10519282", "map_id": "none", "name": "DSCAM:p-S144-PAK1:RAC1:GTP", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10519284", "map_id": "none", "name": "DSCAM associates with Rac1-GTP:pPAK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10519252", "map_id": "none", "name": "Homologues of DSCAM", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10519280", "map_id": "none", "name": "p-S144-PAK1:RAC1:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10526154", "map_id": "none", "name": "Activation of p38MAPK by DSCAM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10518679", "map_id": "none", "name": "Translocation of Ezrin to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10518675", "map_id": "G5EBK3", "name": "erm-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10527529", "map_id": "none", "name": "Netrin-4 binds DCC/UNC5A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10527518", "map_id": "O44565", "name": "lam-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10527525", "map_id": "none", "name": "DCC, UNC5A", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q26261", "map_id": "Q26261", "name": "unc-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006745", "map_id": "WBGene00006745", "name": "unc-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10527527", "map_id": "none", "name": "NTN4:DCC,UNC5A", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10518700", "map_id": "none", "name": "DCC interaction with SIAH1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10518696", "map_id": "Q965X6", "name": "siah-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10518698", "map_id": "none", "name": "NTN1:DCC:SIAH1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10518727", "map_id": "none", "name": "L1 binds RanBPM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10518723", "map_id": "Q9XWK4", "name": "RANBP9", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10518725", "map_id": "none", "name": "L1:RanBPM", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10518546", "map_id": "none", "name": "Neurofascin and NrCAM heterodimerization", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10518542", "map_id": "Q53U87", "name": "sax-7", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10518540", "map_id": "Q53U87", "name": "sax-7", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10518544", "map_id": "none", "name": "NFASC:NRCAM", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10515214", "map_id": "none", "name": "Phosphorylation of PKC theta", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10515211", "map_id": "none", "name": "Active PKC theta bound to DAG", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10508214", "map_id": "none", "name": "3-Oxotetradecanoyl-CoA+CoA-SH<=>Lauroyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_77269", "map_id": "CHEBI:28726", "name": "3-Oxotetradecanoyl-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_77261", "map_id": "CHEBI:15521", "name": "LAU-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10508217", "map_id": "none", "name": "trans-Tetradec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxytetradecanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_77273", "map_id": "CHEBI:27721", "name": "trans-Tetradec-2-enoyl-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_77276", "map_id": "CHEBI:27466", "name": "(S)-3-Hydroxytetradecanoyl-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10508220", "map_id": "none", "name": "(S)-3-Hydroxytetradecanoyl-CoA+NAD<=>3-Oxotetradecanoyl-CoA+NADH+H", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "reaction_10510256", "map_id": "none", "name": "D-fructose 6-phosphate + D-erythrose 4-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29878", "map_id": "CHEBI:16897", "name": "E4P", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_29882", "map_id": "CHEBI:15721", "name": "SH7P", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10503949", "map_id": "none", "name": "TALDO1 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q966C7", "map_id": "Q966C7", "name": "tald-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021286", "map_id": "WBGene00021286", "name": "tald-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10510242", "map_id": "none", "name": "D-glyceraldehyde 3-phosphate + sedoheptulose 7-phosphate<=> xylulose 5-phosphate+ribose 5-phosphate ", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29790", "map_id": "CHEBI:57737", "name": "XY5P", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_73578", "map_id": "CHEBI:78679", "name": "R5P", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10503939", "map_id": "none", "name": "TKT dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "O17759", "map_id": "O17759", "name": "tkt-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008506", "map_id": "WBGene00008506", "name": "tkt-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10510252", "map_id": "none", "name": "D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate <=> xylulose 5-phosphate + D-erythrose 4-phosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10513329", "map_id": "none", "name": "Digestion of cholesterol esters by extracellular CEL (bile salt-dependent lipase)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_171076", "map_id": "CHEBI:17002", "name": "CHEST", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_171149", "map_id": "CHEBI:16113", "name": "CHOL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10513326", "map_id": "none", "name": "dimerized CEL:bile salt complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10513332", "map_id": "none", "name": "Digestion of monoacylglycerols by extracellular CEL (bile salt-dependent lipase)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_6814795", "map_id": "CHEBI:17408", "name": "MAG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10513334", "map_id": "none", "name": "Digestion of triacylglycerols by extracellular CEL (bile salt-dependent lipase)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_171126", "map_id": "CHEBI:17855", "name": "TAGs", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_174675", "map_id": "CHEBI:18035", "name": "DAGs", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10570265", "map_id": "none", "name": "LIPs hydrolyze TG to DAG and LCFA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10570262", "map_id": "none", "name": "digestive LIPs", "type": "catalyst", "sub_type": "", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10554517", "map_id": "none", "name": "AKR1A1 reduces D-glucuronate to L-gulonate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5661264", "map_id": "CHEBI:15748", "name": "D-glucuronate", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_5661268", "map_id": "CHEBI:13115", "name": "L-gulonate", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10554535", "map_id": "none", "name": "XYLB phosphorylates D-xylulose", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5661281", "map_id": "CHEBI:17140", "name": "D-xylulose", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10554532", "map_id": "P30646", "name": "XYLB", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00011147", "map_id": "WBGene00011147", "name": "XYLB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10554538", "map_id": "none", "name": "SORD tetramer oxidizes xylitol to D-xylulose", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5660033", "map_id": "CHEBI:17151", "name": "xylitol", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10554251", "map_id": "none", "name": "SORD tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q21702", "map_id": "Q21702", "name": "SORD", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011003", "map_id": "WBGene00011003", "name": "SORD", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10554509", "map_id": "none", "name": "DCXR tetramer reduces L-xylulose to xylitol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5660036", "map_id": "CHEBI:17399", "name": "L-xylulose", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10554506", "map_id": "none", "name": "DCXR tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q21929", "map_id": "Q21929", "name": "dhs-21", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000984", "map_id": "WBGene00000984", "name": "dhs-21", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10554527", "map_id": "none", "name": "CRYL1 dimer dehydrogenates L-gulonate to 3-dehydro-L-gulonate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5661262", "map_id": "CHEBI:57655", "name": "3-dehydro-L-gulonate", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10554524", "map_id": "none", "name": "CRYL1 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "C0VXV5", "map_id": "C0VXV5", "name": "CRYL1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022130", "map_id": "WBGene00022130", "name": "CRYL1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10543520", "map_id": "none", "name": "Formation of collagen fibres", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10534604", "map_id": "none", "name": "Collagen fibrils", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10543518", "map_id": "none", "name": "Collagen fibres", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10543796", "map_id": "none", "name": "Collagen XI cross-links with collagen II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10534598", "map_id": "none", "name": "Collagen type XI fibril", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10543794", "map_id": "none", "name": "Collagen type XI fibril:Collagen type II fibril", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10543528", "map_id": "none", "name": "Formation of collagen networks", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10543522", "map_id": "none", "name": "Network forming tropocollagens", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10543526", "map_id": "none", "name": "Collagen networks", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10544002", "map_id": "none", "name": "Formation of hydroxylysyl-pyridinoline cross-links", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10543979", "map_id": "none", "name": "Collagen type I fibrils with hydroxylysino-5-ketonorleucine crosslinks", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10544000", "map_id": "none", "name": "Collagen type I fibrils with hydroxylysyl-pyridinoline cross-links", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10544004", "map_id": "none", "name": "Formation of dehydro-hydroxylysino-norleucine cross-links", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10540843", "map_id": "none", "name": "Collagen type I fibril with allysines", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10543638", "map_id": "none", "name": "Collagen type I fibrils with deH-HLNL cross-links", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10543701", "map_id": "none", "name": "Formation of dehydro-lysinonorleucine cross-links", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10543699", "map_id": "none", "name": "Collagen type 1 fibrils cross-linked by dehydro-lysinonorleucine crosslinks", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10544086", "map_id": "none", "name": "Formation of hydroxylysyl-pyrrole cross-links", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10544084", "map_id": "none", "name": "Collagen type I fibrils with hydroxylysyl-pyrrole cross-links", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10544024", "map_id": "none", "name": "Formation of hydroxylysino-5-ketonorleucine cross-links", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10544022", "map_id": "none", "name": "Collagen type I fibril with hydroxyallysines", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10544026", "map_id": "none", "name": "Formation of lysino-5-ketonorleucine cross-links", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10543730", "map_id": "none", "name": "Collagen type I fibrils with lysino-5-ketonorleucine cross-links", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10543754", "map_id": "none", "name": "Formation of lysyl-pyrrole cross-links", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10543752", "map_id": "none", "name": "Collagen type I fibrils with lysyl-pyrrole cross-links", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10543642", "map_id": "none", "name": "Formation of histidino-hydroxylysinonorleucine cross-links", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10543640", "map_id": "none", "name": "Collagen type I fibrils with histidino-hydroxylysinoleucine cross-links", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10544063", "map_id": "none", "name": "Formation of lysyl-pyridinoline cross-links", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10544061", "map_id": "none", "name": "Collagen type I fibrils with lysyl-pyridinoline cross-links", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10543532", "map_id": "none", "name": "Type X collagen associates with collagen type II fibrils", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10543524", "map_id": "none", "name": "Collagen type X network", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10543530", "map_id": "none", "name": "Collagen type X:type II fibrils", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10534606", "map_id": "none", "name": "Formation of collagen fibrils", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10534596", "map_id": "none", "name": "Tropocollagens", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10556034", "map_id": "none", "name": "SIRT4 transfers ADPRib to GLUD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10503183", "map_id": "Q23621", "name": "gdh-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "WBGene00014095", "map_id": "WBGene00014095", "name": "gdh-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10556024", "map_id": "Q23621", "name": "phospho-gdh-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_5688274", "map_id": "CHEBI:17154", "name": "NAM", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10556031", "map_id": "none", "name": "SIRT4:Zn2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q20480", "map_id": "Q20480", "name": "sir-2.2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004801", "map_id": "WBGene00004801", "name": "sir-2.2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10573249", "map_id": "none", "name": "MLKL binds HSP90:CDC37", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10550681", "map_id": "Q07292", "name": "lin-45", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10538179", "map_id": "none", "name": "HSP90", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10538177", "map_id": "none", "name": "CDC37", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10573247", "map_id": "none", "name": "MLKL:HSP90:CDC37", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10505687", "map_id": "none", "name": "Ribosomal scanning ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_72617", "map_id": "none", "name": "eIF1", "type": "catalyst", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10505999", "map_id": "none", "name": "Start codon recognition", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10505631", "map_id": "none", "name": "EIF2S1:EIF2S2:EIF2S3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10505681", "map_id": "Q22918", "name": "EIF5", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00016496", "map_id": "WBGene00016496", "name": "EIF5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10567089", "map_id": "none", "name": "RGGT geranylgeranylates RAB proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1131164", "map_id": "CHEBI:48861", "name": "geranylgeranyl diphosphate", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10566884", "map_id": "none", "name": "RGGT:CHMs:RABs:GDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "G5EBF0", "map_id": "G5EBF0", "name": "glo-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011083", "map_id": "WBGene00011083", "name": "glo-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10567086", "map_id": "none", "name": "RGGTA:RGGTB:GGPP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10567084", "map_id": "none", "name": "CHMs:GGC-RABs:GDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10566886", "map_id": "none", "name": "RGGT:CHM binds RABs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10566765", "map_id": "none", "name": "RABGGTA:RABGGTB:CHMs:GGPP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10566882", "map_id": "none", "name": "RABs:GDP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10566761", "map_id": "none", "name": "RABGGTA and RABGGTB bind", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10566757", "map_id": "P41992", "name": "ggtb-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10566755", "map_id": "Q9TYY0", "name": "RABGGTA", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10566759", "map_id": "none", "name": "RABGGTA:RABGGTB", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10566767", "map_id": "none", "name": "RGGT binds the RAB-binding subunit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10565410", "map_id": "none", "name": "ENGASE hydrolyses unfolded protein:(GlcNAc)2 (Man(9-5)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10531865", "map_id": "none", "name": "Ub-unfolded protein:(GlcNAc)2 (Man)9-5", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_8853371", "map_id": "none", "name": "unfolded protein:GlcNAc", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_8853381", "map_id": "none", "name": "GlcNAc (Man)9-5", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_8853396", "map_id": "CHEBI:91280", "name": "alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "CHEBI:91284", "map_id": "CHEBI:91284", "name": "CHEBI:91284", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:91283", "map_id": "CHEBI:91283", "name": "CHEBI:91283", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:91282", "map_id": "CHEBI:91282", "name": "CHEBI:91282", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:91281", "map_id": "CHEBI:91281", "name": "CHEBI:91281", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10565407", "map_id": "Q8TA65", "name": "eng-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00017164", "map_id": "WBGene00017164", "name": "eng-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10565052", "map_id": "none", "name": "Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1022114", "map_id": "none", "name": "unfolded protein", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_8852852", "map_id": "none", "name": "(GlcNAc)2 (Man)9-5", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10565049", "map_id": "none", "name": "Deglycosylation complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q9TW67", "map_id": "Q9TW67", "name": "png-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010160", "map_id": "WBGene00010160", "name": "png-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9TXH9", "map_id": "Q9TXH9", "name": "ubxn-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017733", "map_id": "WBGene00017733", "name": "ubxn-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P90859", "map_id": "P90859", "name": "hrdl-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009164", "map_id": "WBGene00009164", "name": "hrdl-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q93561", "map_id": "Q93561", "name": "cup-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000843", "map_id": "WBGene00000843", "name": "cup-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10531867", "map_id": "none", "name": "Ub-unfolded protein:(GlcNAc)2 (Man)9-5 translocates from ERQC to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10531863", "map_id": "none", "name": "Ub-unfolded protein:(GlcNAc)2 (Man)9-5", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_927893", "compartment_display": "endoplasmic reticulum quality control compartment", "complex": "true" }, { "id": "reaction_10528423", "map_id": "none", "name": "Binding of ERp57", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_10527333", "map_id": "G5ED07", "name": "pdi-3", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "WBGene00003964", "map_id": "WBGene00003964", "name": "pdi-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10528419", "map_id": "none", "name": "unfolded protein:(Glc)1 (GlcNAc)2 (Man)9 (Asn)1:chaperone", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "CHEBI:59080", "map_id": "CHEBI:59080", "name": "CHEBI:59080", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P27798", "map_id": "P27798", "name": "crt-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000802", "map_id": "WBGene00000802", "name": "crt-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10528421", "map_id": "none", "name": "unfolded protein:(Glc)1 (GlcNAc)2 (Man)9 (Asn)1:chaperone:ERp57", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "G5ED07", "map_id": "G5ED07", "name": "pdi-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10529604", "map_id": "none", "name": "Addition of GlcNAc to the glycan on the A arm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10529601", "map_id": "Q11068", "name": "gly-13", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_6791047", "compartment_display": "endoplasmic reticulum-Golgi intermediate compartment membrane", "complex": "false" }, { "id": "WBGene00001638", "map_id": "WBGene00001638", "name": "gly-13", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10530596", "map_id": "none", "name": "Addition of GlcNAc to position 5 by MGAT5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_981617", "map_id": "none", "name": "Glycoprotein with GlcNAc in position 5", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10530593", "map_id": "Q9NDH7", "name": "gly-2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "WBGene00001627", "map_id": "WBGene00001627", "name": "gly-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10525152", "map_id": "none", "name": "ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_449222", "map_id": "CHEBI:18278", "name": "GlcNAcDOLDP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_453087", "compartment_display": "integral component of cytoplasmic side of endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_449293", "map_id": "CHEBI:18341", "name": "N,N'-DCDOLDP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_453087", "compartment_display": "integral component of cytoplasmic side of endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10525149", "map_id": "none", "name": "ALG13:ALG14", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "P92012", "map_id": "P92012", "name": "algn-13", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011193", "map_id": "WBGene00011193", "name": "algn-13", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "U4PE03", "map_id": "U4PE03", "name": "algn-14", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019725", "map_id": "WBGene00019725", "name": "algn-14", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10525186", "map_id": "none", "name": "Addition of the first mannose to the N-glycan precursor by ALG1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_449283", "map_id": "CHEBI:18396", "name": "MDCDD", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_453087", "compartment_display": "integral component of cytoplasmic side of endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10525183", "map_id": "Q22797", "name": "algn-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "WBGene00020820", "map_id": "WBGene00020820", "name": "algn-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10525074", "map_id": "none", "name": "ALG3 transfers Man to N-glycan precursor (GlcNAc)2 (Man)5 (PP-Dol)1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_449229", "map_id": "CHEBI:15809", "name": "DOLP-Man", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_453088", "compartment_display": "integral component of lumenal side of endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_449298", "map_id": "CHEBI:53022", "name": "(GlcNAc)2 (Man)5 (PP-Dol)1", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_453088", "compartment_display": "integral component of lumenal side of endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_449311", "map_id": "CHEBI:16214", "name": "DOLP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_453088", "compartment_display": "integral component of lumenal side of endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_449315", "map_id": "CHEBI:53023", "name": "(GlcNAc)2 (Man)6 (PP-Dol)1", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_453088", "compartment_display": "integral component of lumenal side of endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10525066", "map_id": "E5QCI3", "name": "algn-3", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "WBGene00010720", "map_id": "WBGene00010720", "name": "algn-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10525072", "map_id": "Q20157", "name": "mpdu-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "WBGene00018181", "map_id": "WBGene00018181", "name": "mpdu-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10525091", "map_id": "none", "name": "Addition of N-acetyl-D-glucosamine to Dolichyl phosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10525088", "map_id": "Q9U1Z2", "name": "algn-7", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "WBGene00013362", "map_id": "WBGene00013362", "name": "algn-7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10525107", "map_id": "none", "name": "ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_449312", "map_id": "CHEBI:59088", "name": "(GlcNAc)2 (Man)7 (PP-Dol)1", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_453088", "compartment_display": "integral component of lumenal side of endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_449365", "map_id": "CHEBI:59091", "name": "(GlcNAc)2 (Man)8 (PP-Dol)1", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_453088", "compartment_display": "integral component of lumenal side of endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10525104", "map_id": "Q23361", "name": "algn-12", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "WBGene00022629", "map_id": "WBGene00022629", "name": "algn-12", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10525127", "map_id": "none", "name": "Addition of the first glucose to the N-glycan precursor by ALG6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_449371", "map_id": "CHEBI:37637", "name": "(GlcNAc)2 (Man)9 (PP-Dol)1", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_453088", "compartment_display": "integral component of lumenal side of endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_532542", "map_id": "CHEBI:15812", "name": "DbGP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_453088", "compartment_display": "integral component of lumenal side of endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_449649", "map_id": "CHEBI:59081", "name": "(Glc)1 (GlcNAc)2 (Man)9 (PP-Dol)1", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_453088", "compartment_display": "integral component of lumenal side of endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10525124", "map_id": "Q09226", "name": "algn-6", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "WBGene00007435", "map_id": "WBGene00007435", "name": "algn-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10525160", "map_id": "none", "name": "Addition of a second mannose to the N-glycan precursor by ALG2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_449737", "map_id": "CHEBI:59085", "name": "(GlcNAc)2 (Man)2 (PP-Dol)1", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_453087", "compartment_display": "integral component of cytoplasmic side of endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10525157", "map_id": "Q19265", "name": "algn-2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "WBGene00017282", "map_id": "WBGene00017282", "name": "algn-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10525176", "map_id": "none", "name": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)6 (PP-Dol)1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_10525173", "map_id": "P54002", "name": "algn-9", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "WBGene00007556", "map_id": "WBGene00007556", "name": "algn-9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10525178", "map_id": "none", "name": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)8 (PP-Dol)1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "reaction_10525083", "map_id": "none", "name": "Addition of a second glucose to the N-glycan precursor by ALG8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_449638", "map_id": "CHEBI:53020", "name": "(Glc)2 (GlcNAc)2 (Man)9 (PP-Dol)1", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_453088", "compartment_display": "integral component of lumenal side of endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10525080", "map_id": "P52887", "name": "algn-8", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "WBGene00007464", "map_id": "WBGene00007464", "name": "algn-8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10565708", "map_id": "none", "name": "PALM-C36-ASGR1:PALM-C54,58-ASGR2 binds desialated glycoproteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_8855720", "map_id": "CHEBI:37396", "name": "proteoglycan", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10565704", "map_id": "none", "name": "PALM-C36-ASGR1:PALM-C54,58-ASGR2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10565706", "map_id": "none", "name": "PALM-C36-ASGR1:PALM-C54,58-ASGR2:proteoglycan", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10510086", "map_id": "none", "name": "glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_8855661", "map_id": "CHEBI:24275", "name": "glucosaminyl-PI", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_453087", "compartment_display": "integral component of cytoplasmic side of endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_8855666", "map_id": "CHEBI:52572", "name": "glucosaminyl-acyl-PI", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_453087", "compartment_display": "integral component of cytoplasmic side of endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10510083", "map_id": "D6RYD7", "name": "pigw-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "WBGene00022447", "map_id": "WBGene00022447", "name": "pigw-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10510118", "map_id": "none", "name": "(ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_8855663", "map_id": "none", "name": "(ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_453088", "compartment_display": "integral component of lumenal side of endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_162872", "map_id": "CHEBI:16214", "name": "dolichyl phosphate", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_8855667", "map_id": "CHEBI:53058", "name": "mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_453088", "compartment_display": "integral component of lumenal side of endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10510115", "map_id": "O02164", "name": "pigv-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "WBGene00020375", "map_id": "WBGene00020375", "name": "pigv-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10510102", "map_id": "none", "name": "mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_8855656", "map_id": "CHEBI:53059", "name": "mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_453088", "compartment_display": "integral component of lumenal side of endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10510099", "map_id": "G5EDN2", "name": "pigb-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "WBGene00194986", "map_id": "WBGene00194986", "name": "pigb-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10510110", "map_id": "none", "name": "N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_8855657", "map_id": "CHEBI:15935", "name": "N-acetylglucosaminyl-PI", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_453087", "compartment_display": "integral component of cytoplasmic side of endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_29416", "map_id": "CHEBI:15366", "name": "CH3COO-", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10510107", "map_id": "D4YWC2", "name": "pigl-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "WBGene00013131", "map_id": "WBGene00013131", "name": "pigl-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10510094", "map_id": "none", "name": "mannose(a1-4)glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose(al1-4)glucosaminyl-acyl-PI + diacylglycerol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_8855659", "map_id": "CHEBI:53056", "name": "mannose (a1-4) glucosaminyl-acyl-PI", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_453088", "compartment_display": "integral component of lumenal side of endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10510091", "map_id": "G4SNP0", "name": "pign-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "WBGene00021840", "map_id": "WBGene00021840", "name": "pign-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10569975", "map_id": "none", "name": "CAND1 binds cytosolic CRL E3 ubiquitin ligases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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"compartment_display": "none" }, { "id": "Q9GRV5", "map_id": "Q9GRV5", "name": "trp-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006616", "map_id": "WBGene00006616", "name": "trp-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q23595", "map_id": "Q23595", "name": "ASB2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00014077", "map_id": "WBGene00014077", "name": "ASB2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A0K3AV89", "map_id": "A0A0K3AV89", "name": "nphp-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Y32G9A.6d", "map_id": "Y32G9A.6d", "name": "nphp-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EBJ4", "map_id": "G5EBJ4", "name": "mlt-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013835", "map_id": "WBGene00013835", "name": "mlt-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O18152", "map_id": "O18152", "name": "ASB3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012124", "map_id": "WBGene00012124", "name": "ASB3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9GYM5", "map_id": 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10556637", "map_id": "none", "name": "UCHL3,SENP8", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10556646", "map_id": "Q93725", "name": "ned-8", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10570089", "map_id": "none", "name": "COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10570082", "map_id": "none", "name": "NEDD8-CRL4 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q93759", "map_id": "Q93759", "name": "swan-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009976", "map_id": "WBGene00009976", "name": "swan-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q22059", "map_id": "Q22059", "name": "cdt-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011318", "map_id": "WBGene00011318", "name": "cdt-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q4W5Q8", "map_id": "Q4W5Q8", "name": "adpr-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00044440", "map_id": "WBGene00044440", "name": "adpr-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q21934", "map_id": "Q21934", "name": "DCAF5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011242", "map_id": "WBGene00011242", "name": "DCAF5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P90794", "map_id": "P90794", "name": "wdr-23", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008419", "map_id": "WBGene00008419", "name": "wdr-23", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q09392", "map_id": "Q09392", "name": "DCAF4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018564", "map_id": "WBGene00018564", "name": "DCAF4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7JP60", "map_id": "Q7JP60", "name": "CCDC22", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019959", "map_id": "WBGene00019959", "name": "CCDC22", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10570086", "map_id": "none", "name": "CRL4 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10570084", "map_id": "Q93725", "name": "ned-8", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10570104", "map_id": "none", "name": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10532188", "map_id": "none", "name": "UBE2D1,2,3:Ubiquitin", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10570093", "map_id": "none", "name": "RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5:hydroxyPro-HIF-alpha", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10570097", "map_id": "none", "name": "ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:NEDD8-CUL2:RBX1:COMMDs:CCDC22:DCUN1D1,2,4,5", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10570102", "map_id": "none", "name": "RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5:UBXN7", "type": "inhibitor", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10569981", "map_id": "none", "name": "CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10569752", "map_id": "none", "name": "RBX1:CUL4:DDB1:DCAFs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10569977", "map_id": "G5ED41", "name": "cand-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10569979", "map_id": "none", "name": "CRL4 E3 ubiquitin ligase:CAND1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10570060", "map_id": "none", "name": "COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10570047", "map_id": "none", "name": "NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9U3C8", "map_id": "Q9U3C8", "name": "dcn-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010428", "map_id": "WBGene00010428", "name": "dcn-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10570057", "map_id": "none", "name": "CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10566026", "map_id": "none", "name": "COP9", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10570095", "map_id": "none", "name": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds hydroxyprolyl-HIF-alpha", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10570091", "map_id": "none", "name": "RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10532134", "map_id": "G5EGD2", "name": "hif-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10520016", "map_id": "none", "name": "EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10520013", "map_id": "none", "name": "p-S52-EIF2S1:EIF2S2:EIF2S3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10519989", "map_id": "none", "name": "PERK dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q19192", "map_id": "Q19192", "name": "pek-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003970", "map_id": "WBGene00003970", "name": "pek-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10519991", "map_id": "none", "name": "Dimerization of PERK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10519980", "map_id": "Q19192", "name": "pek-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "reaction_10520006", "map_id": "none", "name": "IRE1 dimer autophosphorylates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10519998", "map_id": "none", "name": "IRE1 dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q09499", "map_id": "Q09499", "name": "phospho-ire-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002147", "map_id": "WBGene00002147", "name": "phospho-ire-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10520003", "map_id": "none", "name": "p-S724-IRE1 dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10520008", "map_id": "none", "name": "IRE1 binds IRE1 forming dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10519996", "map_id": "Q09499", "name": "ire-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "reaction_10567201", "map_id": "none", "name": "CREB3L3 translocates from the endoplasmic reticulum membrane to the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10567199", "map_id": "O44743", "name": "let-607", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "WBGene00002783", "map_id": "WBGene00002783", "name": "let-607", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10567195", "map_id": "O44743", "name": "let-607", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "reaction_10567187", "map_id": "none", "name": "CREB3L3 translocates from the cytosol to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10567179", "map_id": "O44743", "name": "let-607", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10567185", "map_id": "O44743", "name": "let-607", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10567183", "map_id": "none", "name": "MBTPS2 (S2P) cleaves CREB3L3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10567177", "map_id": "O44743", "name": "let-607", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "species_10567181", "map_id": "O44743", "name": "let-607", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "species_10522008", "map_id": "Q9U227", "name": "MBTPS2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "WBGene00013225", "map_id": "WBGene00013225", "name": "MBTPS2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10519975", "map_id": "none", "name": "ATF6 (ATF6-alpha) translocates from the cytosol to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10519971", "map_id": "Q20435", "name": "atf-6", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00000222", "map_id": "WBGene00000222", "name": "atf-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10519973", "map_id": "Q20435", "name": "atf-6", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10522011", "map_id": "none", "name": "MBTPS2 (S2P) cleaves ATF6 (ATF6-alpha)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10520023", "map_id": "Q20435", "name": "atf-6", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "species_10522003", "map_id": "Q20435", "name": "atf-6", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "reaction_10520031", "map_id": "none", "name": "ATF6 (ATF6-alpha) translocates from the endoplasmic reticulum to the Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10520027", "map_id": "Q20435", "name": "atf-6", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10520021", "map_id": "Q20435", "name": "atf-6", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "reaction_10517698", "map_id": "none", "name": "Exocyst complex formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10517679", "map_id": "Q95Q35", "name": "exoc-8", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10517694", "map_id": "P91149", "name": "exoc-7", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10517659", "map_id": "Q9XWS2", "name": "sec-8", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10517674", "map_id": "Q18286", "name": "sec-15", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10517689", "map_id": "Q19262", "name": "sec-6", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_216813", "compartment_display": "secretory granule membrane", "complex": "false" }, { "id": "species_10517669", "map_id": "Q18406", "name": "sec-10", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10517684", "map_id": "Q20678", "name": "sec-3", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10517664", "map_id": "Q22706", "name": "sec-5", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10517696", "map_id": "none", "name": "Exocyst Complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10555315", "map_id": "none", "name": "MRSBs reduce L-methyl-(R)-S-oxide to L-methionine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5676932", "map_id": "CHEBI:49032", "name": "L-methionine (R)-S-oxide", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10555312", "map_id": "none", "name": "MSRBs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P34436", "map_id": "P34436", "name": "MSRB3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018419", "map_id": "WBGene00018419", "name": "MSRB3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10555323", "map_id": "none", "name": "PCMT1 transfers CH3 from AdoMet to isoAsp to form MetAsp", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5687536", "map_id": "CHEBI:85309", "name": "isoAsp", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_5687529", "map_id": "CHEBI:31882", "name": "MetAsp", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10555320", "map_id": "Q27873", "name": "pcm-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00003954", "map_id": "WBGene00003954", "name": "pcm-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10522946", "map_id": "none", "name": "SLC34A1,2 cotransports Pi, 3Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_109277", "map_id": "CHEBI:43474", "name": "Pi", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10522943", "map_id": "Q23530", "name": "SLC34A2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "WBGene00022767", "map_id": "WBGene00022767", "name": "SLC34A2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10555765", "map_id": "none", "name": "NAPSA, CTSH, PGA3-5 cleave pro-SFTPB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_3828046", "compartment_display": "multivesicular body lumen" }, { "id": "species_10555678", "map_id": "none", "name": "Homologues of pro-SFTPB", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_3828046", "compartment_display": "multivesicular body lumen", "complex": "true" }, { "id": "Q18279", "map_id": "Q18279", "name": "spp-8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004993", "map_id": "WBGene00004993", "name": "spp-8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_5685882", "map_id": "CHEBI:15377", "name": "H2O", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_3828046", "compartment_display": "multivesicular body lumen", "complex": "false" }, { "id": "species_10555690", "map_id": "none", "name": "Homologues of SFTPB(25-200)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_3828046", "compartment_display": "multivesicular body lumen", "complex": "true" }, { "id": "species_10555684", "map_id": "none", "name": "Homologues of SFTPB(201-279)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_3828046", "compartment_display": "multivesicular body lumen", "complex": "true" }, { "id": "species_10555696", "map_id": "none", "name": "Homologues of SFTPB(280-381)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_3828046", "compartment_display": "multivesicular body lumen", "complex": "true" }, { "id": "species_10555762", "map_id": "none", "name": "NAPSA, CTSH, PGA3-5", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_3828046", "compartment_display": "multivesicular body lumen", "complex": "true" }, { "id": "reaction_10555575", "map_id": "none", "name": "ABCA3 transports PC, PG from ER membrane to lamellar body", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_2133233", "compartment_display": "lamellar body membrane" }, { "id": "species_5684863", "map_id": "none", "name": "PC, PG", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "species_194276", "map_id": "CHEBI:16110", "name": "phosphatidylcholines", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_5684869", "map_id": "none", "name": "PC, PG", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_80738", "compartment_display": "lamellar body", "complex": "true" }, { "id": "species_10555572", "map_id": "Q9TXV8", "name": "abt-4", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_2133233", "compartment_display": "lamellar body membrane", "complex": "false" }, { "id": "WBGene00000022", "map_id": "WBGene00000022", "name": "abt-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10558534", "map_id": "none", "name": "SFTPB binds itself", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_3828046", "compartment_display": "multivesicular body lumen" }, { "id": "species_10555767", "map_id": "none", "name": "SFTPB dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_3828046", "compartment_display": "multivesicular body lumen", "complex": "true" }, { "id": "reaction_10572265", "map_id": "none", "name": "pro-SFTPB translocates from ER membrane to multivesicle body", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10572263", "map_id": "none", "name": "Homologues of pro-SFTPB", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10509923", "map_id": "none", "name": "GTP-binding activates eEF2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10509921", "map_id": "none", "name": "eEF2:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10505689", "map_id": "none", "name": "Formation of the cap-binding eIF4F complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10505660", "map_id": "O61955", "name": "ife-3", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10505655", "map_id": "none", "name": "eIF4A subunits complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10505667", "map_id": "none", "name": "eIF4F", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10505697", "map_id": "none", "name": "Met-tRNAi binds to eIF2:GTP to form the ternary complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_72393", "map_id": "none", "name": "Met-tRNAi", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10505635", "map_id": "none", "name": "ternary complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10505997", "map_id": "none", "name": "Formation of the 43S pre-initiation complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10505993", "map_id": "none", "name": "40S:eIF3:eIF1A", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10505695", "map_id": "none", "name": "De novo formation of eIF2:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10505987", "map_id": "none", "name": "eIF5B:GTP is hydrolyzed and released", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10505981", "map_id": "none", "name": "80S:Met-tRNAi:mRNA:eIF5B:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "G5EGT7", "map_id": "G5EGT7", "name": "iffb-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021857", "map_id": "WBGene00021857", "name": "iffb-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10505983", "map_id": "none", "name": "eIF5B:GDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10505985", "map_id": "none", "name": "80S:Met-tRNAi:mRNA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10505989", "map_id": "none", "name": "The 60S subunit joins the translation initiation complex ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10505979", "map_id": "none", "name": "eIF5B:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10505683", "map_id": "none", "name": "40S:Met-tRNAi:mRNA", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10505991", "map_id": "none", "name": "Release of 40S and 60S subunits from the 80S ribosome ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10505972", "map_id": "none", "name": "80S ribosome", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10505542", "map_id": "none", "name": "40S ribosomal complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10505995", "map_id": "none", "name": "eIF3 and eIF1A bind to the 40S subunit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10505609", "map_id": "none", "name": "eIF3 subunits complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10537497", "map_id": "none", "name": "Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10537493", "map_id": "none", "name": "ribosome:mRNA:polypeptide+signal", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10537491", "map_id": "none", "name": "Signal Recognition Particle", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "G5EE80", "map_id": "G5EE80", "name": "SRP54", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009012", "map_id": "WBGene00009012", "name": "SRP54", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P91240", "map_id": "P91240", "name": "srpa-72", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017245", "map_id": "WBGene00017245", "name": "srpa-72", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34642", "map_id": "P34642", "name": "SRP9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013984", "map_id": "WBGene00013984", "name": "SRP9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O61749", "map_id": "O61749", "name": "SRP19", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018159", "map_id": "WBGene00018159", "name": "SRP19", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q20822", "map_id": "Q20822", "name": "srpa-68", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010097", "map_id": "WBGene00010097", "name": "srpa-68", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10537495", "map_id": "none", "name": "SRP:polypeptide+signal:ribosome", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10556841", "map_id": "none", "name": "APEH hydrolyses NAc-Ser-protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5691496", "map_id": "none", "name": "NAc-Ser:protein", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_5691517", "map_id": "CHEBI:83690", "name": "NAc-Ser residue", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_6785226", "map_id": "CHEBI:36080", "name": "protein", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10556838", "map_id": "Q9TYX1", "name": "dpf-5", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10562140", "map_id": "none", "name": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to ETF1 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10562118", "map_id": "none", "name": "ETF1 dimer:eRF3:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10562125", "map_id": "none", "name": "Me-Q185-ETF1 dimer:eRF3:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10535108", "map_id": "none", "name": "PC is converted to PS by PTDSS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10535105", "map_id": "Q09643", "name": "pssy-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "WBGene00013920", "map_id": "WBGene00013920", "name": "pssy-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10534897", "map_id": "none", "name": "PC is hydrolyzed to 1-acyl LPC by PLA2[6]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_1524028", "map_id": "CHEBI:17504", "name": "1-acyl LPC", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10534894", "map_id": "none", "name": "PLA2(6)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q8MXR3", "map_id": "Q8MXR3", "name": "ipla-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022233", "map_id": "WBGene00022233", "name": "ipla-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10534753", "map_id": "none", "name": "1-acyl LPC is acylated to PC by LPCAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10534731", "map_id": "none", "name": "LPCAT", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10567209", "map_id": "none", "name": "THEM86B hydrolyses PMCHO, PMETAM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_8874447", "map_id": "none", "name": "PMCHO, PMETAM", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "CHEBI:17810", "map_id": "CHEBI:17810", "name": "CHEBI:17810", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:17476", "map_id": "CHEBI:17476", "name": "CHEBI:17476", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_8874450", "map_id": "none", "name": "GPCHO, GPETAM", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "CHEBI:36313", "map_id": "CHEBI:36313", "name": "CHEBI:36313", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:36314", "map_id": "CHEBI:36314", "name": "CHEBI:36314", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10567206", "map_id": "Q21552", "name": "TMEM86B", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "WBGene00010943", "map_id": "WBGene00010943", "name": "TMEM86B", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10534907", "map_id": "none", "name": "PC is hydrolyzed to 1-acyl LPC by PLA2[5]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "reaction_10535867", "map_id": "none", "name": "PC is hydrolyzed to 1-acyl LPC by PLB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_1602390", "map_id": "CHEBI:17504", "name": "1-acyl LPC", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10535869", "map_id": "none", "name": "PC is hydrolyzed to 1-acyl LPC by PLA2[16]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "reaction_10534734", "map_id": "none", "name": "2-acyl LPC is acylated to PC by LPCAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_975614", "map_id": "CHEBI:16728", "name": "2-acyl LPC", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "reaction_10534914", "map_id": "none", "name": "PI is hydrolyzed to 1-acyl LPI by PLA2[12]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_1498733", "map_id": "CHEBI:28914", "name": "1-acyl LPI", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "reaction_10534789", "map_id": "none", "name": "2-acyl LPI is acylated to PI by MBOAT7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_1498737", "map_id": "CHEBI:62746", "name": "2-acyl LPI", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10534763", "map_id": "Q19468", "name": "mboa-7", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "WBGene00008806", "map_id": "WBGene00008806", "name": "mboa-7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10535862", "map_id": "none", "name": "PI is hydrolyzed to 1-acyl LPI by PLA2[15]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_426658", "map_id": "CHEBI:16749", "name": "PI", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_1602420", "map_id": "CHEBI:28914", "name": "1-acyl LPI", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10534766", "map_id": "none", "name": "1-acyl LPI is acylated to PI by MBOAT7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "reaction_10557548", "map_id": "none", "name": "AGK:Mg2+ phosphorylates MAG, DAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane" }, { "id": "species_5696066", "map_id": "none", "name": "MAG,DAG", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "true" }, { "id": "species_5696069", "map_id": "CHEBI:30616", "name": "ATP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "false" }, { "id": "species_5696026", "map_id": "CHEBI:456216", "name": "ADP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "false" }, { "id": "species_5696037", "map_id": "none", "name": "LPA,PA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "true" }, { "id": "species_10557545", "map_id": "none", "name": "AGK:Mg2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "true" }, { "id": "Q10123", "map_id": "Q10123", "name": "AGK", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018674", "map_id": "WBGene00018674", "name": "AGK", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10534916", "map_id": "none", "name": "PE is hydrolyzed to 1-acyl LPE by PLA2[2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_1498738", "map_id": "CHEBI:29017", "name": "1-acyl LPE", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "reaction_10534918", "map_id": "none", "name": "PE is hydrolyzed to 1-acyl LPE by PLA2[3]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "reaction_10535864", "map_id": "none", "name": "PE is hydrolyzed to 1-acyl LPE by PLA2[16]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_1602375", "map_id": "CHEBI:16038", "name": "PE", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_1602372", "map_id": "CHEBI:29017", "name": "1-acyl LPE", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10557512", "map_id": "none", "name": "ABHD4 hydrolyses NAPE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5694568", "map_id": "CHEBI:61232", "name": "NAPE", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_5694580", "map_id": "CHEBI:52571", "name": "GPAEA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_5694567", "map_id": "CHEBI:22221", "name": "acyl group", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10557509", "map_id": "O02218", "name": "lid-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "WBGene00007711", "map_id": "WBGene00007711", "name": "lid-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10534842", "map_id": "none", "name": "1-acyl LPE is acylated to PE by LPEAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10534808", "map_id": "none", "name": "LPEAT", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10534811", "map_id": "none", "name": "2-acyl LPE is acylated to PE by LPEAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_1498729", "map_id": "CHEBI:28936", "name": "2-acyl LPE", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "reaction_10534786", "map_id": "none", "name": "PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane" }, { "id": "species_1500590", "map_id": "CHEBI:16337", "name": "PA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "false" }, { "id": "species_1500580", "map_id": "CHEBI:16975", "name": "1-acyl LPA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "false" }, { "id": "species_1524103", "map_id": "CHEBI:57560", "name": "LCFA(-)", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "false" }, { "id": "reaction_10534981", "map_id": "none", "name": "DHAP is converted to 1-acyl GO3P by GNPAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_75973", "map_id": "CHEBI:17197", "name": "GO3P", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10534978", "map_id": "G5EFP8", "name": "acl-7", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane", "complex": "false" }, { "id": "WBGene00012911", "map_id": "WBGene00012911", "name": "acl-7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10512710", "map_id": "none", "name": "Gly-3-P+FAD->DHAP+FADH2 (catalyzed by mitochondrial Gly-Phos dehydrogenase)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_188458", "map_id": "CHEBI:15978", "name": "G3P", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_188451", "map_id": "CHEBI:57642", "name": "DHAP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10512707", "map_id": "P90795", "name": "gpdh-3", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "WBGene00012031", "map_id": "WBGene00012031", "name": "gpdh-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10534758", "map_id": "none", "name": "1-acyl LPA is acylated to PA by AGPAT5 (OM)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane" }, { "id": "species_10534755", "map_id": "Q95R12", "name": "acl-11", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "false" }, { "id": "WBGene00017888", "map_id": "WBGene00017888", "name": "acl-11", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10534839", "map_id": "none", "name": "PA is hydrolysed to 1-acyl LPA by PLA2[1]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1500604", "map_id": "CHEBI:16975", "name": "1-acyl LPA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10534855", "map_id": "none", "name": "PA is hydrolysed to 1-acyl LPA by PLA2G2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "reaction_10507577", "map_id": "none", "name": "DHAP is converted to G3P by GPD1/GPD1L", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10507574", "map_id": "none", "name": "GPD1/GPD1L homodimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9XTS4", "map_id": "Q9XTS4", "name": "gpdh-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009824", "map_id": "WBGene00009824", "name": "gpdh-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34517", "map_id": "P34517", "name": "gpdh-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010778", "map_id": "WBGene00010778", "name": "gpdh-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10527340", "map_id": "none", "name": "G3P is acylated to 1-acyl LPA by AGPAT6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10507520", "map_id": "none", "name": "Homologues of AGPAT6", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "G5EE59", "map_id": "G5EE59", "name": "AGPAT6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010902", "map_id": "WBGene00010902", "name": "AGPAT6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q21812", "map_id": "Q21812", "name": "acl-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011106", "map_id": "WBGene00011106", "name": "acl-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9N5S8", "map_id": "Q9N5S8", "name": "acl-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018657", "map_id": "WBGene00018657", "name": "acl-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10507532", "map_id": "none", "name": "1-acyl LPA is acylated to PA by AGPAT (LPAAT)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10507529", "map_id": "none", "name": "AGPAT", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "O16526", "map_id": "O16526", "name": "acl-8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q93841", "map_id": "Q93841", "name": "acl-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010339", "map_id": "WBGene00010339", "name": "acl-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q95R12", "map_id": "Q95R12", "name": "acl-11", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10535100", "map_id": "none", "name": "PC is hydrolyzed to PA and choline by PLD1/2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10535095", "map_id": "G5EDU3", "name": "pld-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "reaction_10534863", "map_id": "none", "name": "G3P is acylated to 1-acyl LPA by GPAM/GPAT2 (OM)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane" }, { "id": "reaction_10535871", "map_id": "none", "name": "PA is hydrolyzed to 1-acyl LPA by PLA2[15]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_1602447", "map_id": "CHEBI:16975", "name": "1-acyl LPA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10569180", "map_id": "none", "name": "PLA2G15 hydrolyses LPC to GPCho and LCFA(-)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_2173763", "map_id": "CHEBI:60479", "name": "lysoPC", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_8954142", "map_id": "CHEBI:57560", "name": "LCFA(-)", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_8952253", "map_id": "CHEBI:16870", "name": "GPCho", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10569177", "map_id": "Q21515", "name": "PLA2G15", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "WBGene00010872", "map_id": "WBGene00010872", "name": "LCAT", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10534976", "map_id": "none", "name": "CDP-DAG is converted to PI by CDIPT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_426955", "map_id": "CHEBI:17962", "name": "CDP-DAG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10534973", "map_id": "none", "name": "CDIPT:Mg2+/Mn2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q9U2G1", "map_id": "Q9U2G1", "name": "pisy-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012897", "map_id": "WBGene00012897", "name": "pisy-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10535085", "map_id": "none", "name": "PA is converted to CDP-DAG by CDS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10535082", "map_id": "none", "name": "CDS1:Mg2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "P53439", "map_id": "P53439", "name": "cdgs-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10566702", "map_id": "none", "name": "PITPNM1,2,3 exchange PI for PA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10566697", "map_id": "G5EED9", "name": "pitp-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00010813", "map_id": "WBGene00010813", "name": "pitp-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10535034", "map_id": "none", "name": "PG and CDP-DAG are converted to CL by CRLS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane" }, { "id": "species_1524067", "map_id": "CHEBI:17361", "name": "cytidine 5'-monophosphate", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10535057", "map_id": "none", "name": "PCho and CTP are condensed to CDP-Cho by PCYT1 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_1524071", "map_id": "CHEBI:36700", "name": "PCho", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_1524060", "map_id": "CHEBI:16436", "name": "CDP-Cho", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10535054", "map_id": "none", "name": "PCYT1 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q8IU09", "map_id": "Q8IU09", "name": "PCYT1A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021215", "map_id": "WBGene00021215", "name": "PCYT1A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P49583", "map_id": "P49583", "name": "PCYT1B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017241", "map_id": "WBGene00017241", "name": "PCYT1B", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10534947", "map_id": "none", "name": "CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10534944", "map_id": "none", "name": "CEPT1:Mg2+/Mn2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10534966", "map_id": "none", "name": "CDP-Cho and DAG are converted to PC by CHPT1 at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_1524057", "map_id": "CHEBI:17815", "name": "DAG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "species_10534963", "map_id": "none", "name": "CHPT1:Mg2+/Mn2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "reaction_10535031", "map_id": "none", "name": "Cho is phosphorylated to PCho by CHK dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10557483", "map_id": "none", "name": "ABHD3 hydrolyses LPC(14:0) to 1AGPC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_5694502", "map_id": "CHEBI:64483", "name": "LPC(14:0)", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_5694457", "map_id": "CHEBI:11230", "name": "1AGPC", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_1861754", "map_id": "CHEBI:33575", "name": "RCOOH", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10557480", "map_id": "none", "name": "Homologues of ABHD3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q18610", "map_id": "Q18610", "name": "abhd-3.2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016644", "map_id": "WBGene00016644", "name": "abhd-3.2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9U1Z6", "map_id": "Q9U1Z6", "name": "abhd-3.1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013358", "map_id": "WBGene00013358", "name": "abhd-3.1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10567146", "map_id": "none", "name": "Casein kinase II phosphorylates STARD10", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10567141", "map_id": "O18155", "name": "STARD10", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00012127", "map_id": "WBGene00012127", "name": "phospho-p-S284-STARD10", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10567144", "map_id": "O18155", "name": "phospho-p-S284-STARD10", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10518395", "map_id": "none", "name": "AcCho is hydrolyzed to Cho and acetate by ACHE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_1524044", "map_id": "CHEBI:30089", "name": "acetate", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10518390", "map_id": "none", "name": "Cholinesterase", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q23268", "map_id": "Q23268", "name": "cest-2.3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013873", "map_id": "WBGene00013873", "name": "cest-2.3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "H9G2Y9", "map_id": "H9G2Y9", "name": "cest-2.2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013874", "map_id": "WBGene00013874", "name": "cest-2.2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A1C3NSL8", "map_id": "A0A1C3NSL8", "name": "cest-26", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017478", "map_id": "WBGene00017478", "name": "cest-26", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q4LDP0", "map_id": "Q4LDP0", "name": "cest-24", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020891", "map_id": "WBGene00020891", "name": "cest-24", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q21266", "map_id": "Q21266", "name": "cest-17", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019477", "map_id": "WBGene00019477", "name": "cest-17", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O01302", "map_id": "O01302", "name": "cest-1.1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011362", "map_id": "WBGene00011362", "name": "cest-1.1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EDJ7", "map_id": "G5EDJ7", "name": "cest-2.1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013875", "map_id": "WBGene00013875", "name": "cest-2.1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XW75", "map_id": "Q9XW75", "name": "cest-12", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013540", "map_id": "WBGene00013540", "name": "cest-12", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q22008", "map_id": "Q22008", "name": "cest-19", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020125", "map_id": "WBGene00020125", "name": "cest-19", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P92016", "map_id": "P92016", "name": "cest-1.2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011364", "map_id": "WBGene00011364", "name": "cest-1.2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "H2L0K7", "map_id": "H2L0K7", "name": "cest-16", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020330", "map_id": "WBGene00020330", "name": "cest-16", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10518393", "map_id": "none", "name": "ACHE:ACHEIs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10567581", "map_id": "none", "name": "STARD7 binds PC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10567577", "map_id": "Q17764", "name": "STARD7", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "false" }, { "id": "WBGene00007386", "map_id": "WBGene00007386", "name": "STARD7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10567579", "map_id": "none", "name": "STARD7:PC", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q17764", "map_id": "Q17764", "name": "STARD7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10535075", "map_id": "none", "name": "PI is exchanged with PC by PITPNB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10535071", "map_id": "none", "name": "PI:PITPNB", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "Q95XP0", "map_id": "Q95XP0", "name": "PITPNB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022155", "map_id": "WBGene00022155", "name": "PITPNB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q965T2", "map_id": "Q965T2", "name": "PITPNB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10535073", "map_id": "none", "name": "PC:PITPNB", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "reaction_10535139", "map_id": "none", "name": "PC:PITPNB is transported from the Golgi membrane to the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10535137", "map_id": "none", "name": "PC:PITPNB", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10535148", "map_id": "none", "name": "PI:PITPNB is transported from the ER membrane to the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10535141", "map_id": "none", "name": "PI:PITPNB", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10507366", "map_id": "none", "name": "Formation of RAD50:MRE11 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10507357", "map_id": "O44199", "name": "rad-50", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00004296", "map_id": "WBGene00004296", "name": "rad-50", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10507362", "map_id": "Q23255", "name": "mre-11", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10507364", "map_id": "none", "name": "RAD50:MRE11A", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "O44199", "map_id": "O44199", "name": "rad-50", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10571888", "map_id": "none", "name": "PEX19 binds class I peroxisomal membrane proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10571868", "map_id": "none", "name": "Class I Peroxisomal Membrane Proteins", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P54815", "map_id": "P54815", "name": "mspn-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010557", "map_id": "WBGene00010557", "name": "mspn-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7YWV6", "map_id": "Q7YWV6", "name": "PXMP2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011826", "map_id": "WBGene00011826", "name": "PXMP2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q6AHP8", "map_id": "Q6AHP8", "name": "fis-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001425", "map_id": "WBGene00001425", "name": "fis-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P91262", "map_id": "P91262", "name": "pxmp-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017574", "map_id": "WBGene00017574", "name": "pxmp-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q18598", "map_id": "Q18598", "name": "pmp-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004059", "map_id": "WBGene00004059", "name": "pmp-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10520426", "map_id": "P34453", "name": "prx-19", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00004201", "map_id": "WBGene00004201", "name": "prx-19", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10571870", "map_id": "none", "name": "PEX19:class I PMP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P34453", "map_id": "P34453", "name": "prx-19", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10571884", "map_id": "none", "name": "PEX3:PEX19:class I PMP dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane" }, { "id": "species_10571872", "map_id": "none", "name": "PEX3:PEX19:class I PMP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane", "complex": "true" }, { "id": "Q18028", "map_id": "Q18028", "name": "prx-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004193", "map_id": "WBGene00004193", "name": "prx-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10571882", "map_id": "none", "name": "Class I Peroxisomal Membrane Proteins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane", "complex": "true" }, { "id": "species_10520404", "map_id": "Q18028", "name": "prx-3", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane", "complex": "false" }, { "id": "reaction_10571886", "map_id": "none", "name": "PEX19:class I PMP binds PEX3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane" }, { "id": "reaction_10551384", "map_id": "none", "name": "FABPs bind LCFAs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_8876730", "map_id": "CHEBI:57560", "name": "LCFA(-)", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10551380", "map_id": "none", "name": "FABPs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10551382", "map_id": "none", "name": "FABPs:LCFA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10564685", "map_id": "none", "name": "PNPLA5 hydrolyzes TAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10564682", "map_id": "none", "name": "Homologues of PNPLA5", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10571751", "map_id": "none", "name": "PEX2:PEX10:PEX12 monoubiquitinates PEX5L at cysteine-11", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane" }, { "id": "species_10571746", "map_id": "none", "name": "PEX2:PEX10:PEX12:PEX5L:Ub:UBE2D1,2,3:PEX7:PEX13:PEX14", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane", "complex": "true" }, { "id": "species_10571748", "map_id": "none", "name": "PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane", "complex": "true" }, { "id": "reaction_10571738", "map_id": "none", "name": "Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane" }, { "id": "species_10571710", "map_id": "none", "name": "PEX5S,L:Cargo:PEX13:PEX14:PEX2:PEX10:PEX12", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane", "complex": "true" }, { "id": "Q18122", "map_id": "Q18122", "name": "AMACR", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O16249", "map_id": "O16249", "name": "IDE", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018426", "map_id": "WBGene00018426", "name": "IDE", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q17499", "map_id": "Q17499", "name": "CRAT", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A486WVT5", "map_id": "A0A486WVT5", "name": "CROT", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XW87", "map_id": "Q9XW87", "name": "lonp-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013541", "map_id": "WBGene00013541", "name": "lonp-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P91148", "map_id": "P91148", "name": "ndx-7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O01739", "map_id": "O01739", "name": "ddo-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017648", "map_id": "WBGene00017648", "name": "ddo-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O45307", "map_id": "O45307", "name": "ddo-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008127", "map_id": "WBGene00008127", "name": "ddo-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q19564", "map_id": "Q19564", "name": "ddo-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017565", "map_id": "WBGene00017565", "name": "ddo-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q95XG9", "map_id": "Q95XG9", "name": "daao-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022076", "map_id": "WBGene00022076", "name": "daao-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EFP8", "map_id": "G5EFP8", "name": "acl-7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q94055", "map_id": "Q94055", "name": "agxt-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011767", "map_id": "WBGene00011767", "name": "agxt-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q18006", "map_id": "Q18006", "name": "PIPOX", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00015783", "map_id": "WBGene00015783", "name": "PIPOX", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O76383", "map_id": "O76383", "name": "hpo-15", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016061", "map_id": "WBGene00016061", "name": "hpo-15", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q20048", "map_id": "Q20048", "name": "mlcd-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q95XN1", "map_id": "Q95XN1", "name": "HMGCL(1-325)", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022150", "map_id": "WBGene00022150", "name": "HMGCL(1-325)", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O17761", "map_id": "O17761", "name": "ech-8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q20959", "map_id": "Q20959", "name": "ECH1(1-328)", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019022", "map_id": "WBGene00019022", "name": "ECH1(1-328)", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9NA25", "map_id": "Q9NA25", "name": "ndx-8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003585", "map_id": "WBGene00003585", "name": "ndx-8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10571736", "map_id": "none", "name": "Cargo proteins containing PTS1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "true" }, { "id": "reaction_10571740", "map_id": "none", "name": "PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane" }, { "id": "species_10571708", "map_id": "none", "name": "PEX13:PEX14:PEX2:PEX10:PEX12", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane", "complex": "true" }, { "id": "species_10571706", "map_id": "none", "name": "PEX5S,L:Cargo protein", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10572195", "map_id": "none", "name": "SGTA binds mislocalized membrane protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10572191", "map_id": "none", "name": "Mislocalized membrane protein", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10571993", "map_id": "none", "name": "SGTA dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q21746", "map_id": "Q21746", "name": "sgt-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019893", "map_id": "WBGene00019893", "name": "sgt-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10572193", "map_id": "none", "name": "Mislocalized membrane protein:SGTA dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10572045", "map_id": "none", "name": "SGTA binds Tail-anchored protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10572041", "map_id": "none", "name": "Tail-anchored proteins", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q93838", "map_id": "Q93838", "name": "serp-1.1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010337", "map_id": "WBGene00010337", "name": "serp-1.1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8MXH3", "map_id": "Q8MXH3", "name": "serp-1.2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020374", "map_id": "WBGene00020374", "name": "serp-1.2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q95XS2", "map_id": "Q95XS2", "name": "sec-61.b", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021427", "map_id": "WBGene00021427", "name": "sec-61.b", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q19967", "map_id": "Q19967", "name": "sec-61.G", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001303", "map_id": "WBGene00001303", "name": "sec-61.G", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A2K5ATR7", "map_id": "A0A2K5ATR7", "name": "ubc-26", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022450", "map_id": "WBGene00022450", "name": "ubc-26", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10572043", "map_id": "none", "name": "Tail-anchored protein:SGTA dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10528387", "map_id": "none", "name": "Release of GABA at the synapse", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10528368", "map_id": "none", "name": "Docked GABA loaded synaptic vesicle", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "G5EDB7", "map_id": "G5EDB7", "name": "unc-25", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006762", "map_id": "WBGene00006762", "name": "unc-25", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34579", "map_id": "P34579", "name": "unc-47", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006783", "map_id": "WBGene00006783", "name": "unc-47", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10528374", "map_id": "P09446", "name": "hsp-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10528372", "map_id": "E5QCE7", "name": "dnj-14", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10516754", "map_id": "Q22366", "name": "unc-10", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10528370", "map_id": "P34579", "name": "unc-47", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10528384", "map_id": "none", "name": "PXLP-GAD dimers", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10528390", "map_id": "none", "name": "Loading of GABA into clathrin sculpted GABA transport vesicle lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_352011", "map_id": "CHEBI:59888", "name": "GABA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_428571", "map_id": "CHEBI:59888", "name": "GABA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_917775", "compartment_display": "clathrin-sculpted gamma-aminobutyric acid transport vesicle lumen", "complex": "false" }, { "id": "species_10528334", "map_id": "P34579", "name": "unc-47", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_917757", "compartment_display": "clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane", "complex": "false" }, { "id": "reaction_10529192", "map_id": "none", "name": "GABA loaded synaptic vesicle Docking and Priming", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_917758", "compartment_display": "clathrin-sculpted gamma-aminobutyric acid transport vesicle" }, { "id": "species_10528366", "map_id": "none", "name": "GABA Loaded synaptic vesicle", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_917757", "compartment_display": "clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane", "complex": "true" }, { "id": "reaction_10528325", "map_id": "none", "name": "Synthesis of GABA by GAD2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_917757", "compartment_display": "clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane" }, { "id": "species_10528322", "map_id": "none", "name": "PXLP-GAD dimers", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_917757", "compartment_display": "clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane", "complex": "true" }, { "id": "reaction_10528313", "map_id": "none", "name": "PXLP-K405-GAD1 decarboxylates L-Glu to form GABA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10528310", "map_id": "none", "name": "PXLP-K405-GAD1 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_917757", "compartment_display": "clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane", "complex": "true" }, { "id": "reaction_10511628", "map_id": "none", "name": "Dephosphorylation of phospho-Cdh1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10511618", "map_id": "Q09649", "name": "phospho-fzr-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10511606", "map_id": "Q09649", "name": "fzr-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10511625", "map_id": "none", "name": "phospho-Cdh1 phosphatase", "type": "catalyst", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10563824", "map_id": "none", "name": "Envoplakin binds periplakin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10563820", "map_id": "A0A1N7SYP3", "name": "vab-10", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10563818", "map_id": "A0A1N7SYP3", "name": "vab-10", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10563822", "map_id": "none", "name": "EVPL:PPL", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10564246", "map_id": "none", "name": "EVL:PPL heterodimer binds the inner surface of the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10563826", "map_id": "none", "name": "EVPL:PPL:Cell surface", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10564473", "map_id": "none", "name": "PERP binds desmosomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10564455", "map_id": "G5ED30", "name": "vab-9", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "WBGene00006875", "map_id": "WBGene00006875", "name": "vab-9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10564469", "map_id": "none", "name": "Desmosome", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10564471", "map_id": "none", "name": "Desmosome:PERP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "G5ED30", "map_id": "G5ED30", "name": "vab-9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10558492", "map_id": "none", "name": "LIPs hydrolyse TG to DAG and RCOOH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_6789319", "map_id": "CHEBI:33575", "name": "RCOOH", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10558489", "map_id": "none", "name": "keratinocyte LIPs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "O16956", "map_id": "O16956", "name": "lipl-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020016", "map_id": "WBGene00020016", "name": "lipl-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q20449", "map_id": "Q20449", "name": "lipl-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009773", "map_id": "WBGene00009773", "name": "lipl-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q93789", "map_id": "Q93789", "name": "lipl-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010062", "map_id": "WBGene00010062", "name": "lipl-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O17766", "map_id": "O17766", "name": "lipl-7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008510", "map_id": "WBGene00008510", "name": "lipl-7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O61866", "map_id": "O61866", "name": "lipl-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022642", "map_id": "WBGene00022642", "name": "lipl-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q94252", "map_id": "Q94252", "name": "lipl-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019376", "map_id": "WBGene00019376", "name": "lipl-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "E2S7J2", "map_id": "E2S7J2", "name": "lipl-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021963", "map_id": "WBGene00021963", "name": "lipl-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9U276", "map_id": "Q9U276", "name": "lipl-8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013050", "map_id": "WBGene00013050", "name": "lipl-8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10571492", "map_id": "none", "name": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9024577", "map_id": "CHEBI:138612", "name": "4S(5)-epoxy-17(R)-HDHA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_9024570", "map_id": "none", "name": "AT-RvD3, AT-RvD4", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:138615", "map_id": "CHEBI:138615", "name": "CHEBI:138615", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:138616", "map_id": "CHEBI:138616", "name": "CHEBI:138616", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10571494", "map_id": "none", "name": "GPX4-2 reduces 17(R)-Hp-DHA to 17(R)-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9024522", "map_id": "CHEBI:138590", "name": "17(R)-Hp-DHA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_9024463", "map_id": "CHEBI:91137", "name": "17(R)-HDHA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10571484", "map_id": "none", "name": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9024602", "map_id": "CHEBI:138613", "name": "7S(8)-epoxy-17(R)-HDHA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_9024574", "map_id": "none", "name": "AT-RvD1, AT-RvD2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:138179", "map_id": "CHEBI:138179", "name": "CHEBI:138179", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:138614", "map_id": "CHEBI:138614", "name": "CHEBI:138614", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10571490", "map_id": "none", "name": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9024768", "map_id": "CHEBI:138646", "name": "7S(8)-epoxy-17(S)-HDHA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_9024759", "map_id": "none", "name": "RvD1, RvD2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:81565", "map_id": "CHEBI:81565", "name": "CHEBI:81565", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:81564", "map_id": "CHEBI:81564", "name": "CHEBI:81564", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10571496", "map_id": "none", "name": "GPX4-2 reduces 17(S)-Hp-DHA to 17(S)-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9024012", "map_id": "CHEBI:136113", "name": "17(S)-Hp-DHA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_9024815", "map_id": "CHEBI:138640", "name": "17(S)-HDHA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10571486", "map_id": "none", "name": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(S)-HDHA to RvD3 or RvD4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9024781", "map_id": "CHEBI:138647", "name": "4S(5)-epoxy-17(S)-HDHA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_9024809", "map_id": "none", "name": "RvD3, RvD4", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:138649", "map_id": "CHEBI:138649", "name": "CHEBI:138649", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:138648", "map_id": "CHEBI:138648", "name": "CHEBI:138648", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10571488", "map_id": "none", "name": "LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9024893", "map_id": "CHEBI:140192", "name": "17R(16)-epoxy-DHA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_9024879", "map_id": "CHEBI:140202", "name": "AT-(N)PD1", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10571541", "map_id": "none", "name": "LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9024873", "map_id": "CHEBI:140225", "name": "16S,17S-epoxy-DHA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_9024886", "map_id": "CHEBI:138655", "name": "(N)PD1", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10555584", "map_id": "none", "name": "p-T68-CHEK2 autophosphorylates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10555579", "map_id": "none", "name": "p-T68-CHEK2 dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9U1Y5", "map_id": "Q9U1Y5", "name": "phospho-chk-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10555635", "map_id": "none", "name": "ATM phosphorylates EYA1-4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10555610", "map_id": "O17670", "name": "eya-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00001377", "map_id": "WBGene00001377", "name": "eya-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10555619", "map_id": "O17670", "name": "phospho-eya-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10555632", "map_id": "none", "name": "DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139,Y142-H2AFX-Nucleosome", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q19649", "map_id": "Q19649", "name": "HIST3H3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017638", "map_id": "WBGene00017638", "name": "HIST3H3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q23429", "map_id": "Q23429", "name": "htas-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00014240", "map_id": "WBGene00014240", "name": "htas-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10555638", "map_id": "none", "name": "EYA1-4 dephosphorylates tyrosine Y142 of H2AFX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10555554", "map_id": "none", "name": "DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10556984", "map_id": "none", "name": "ATM phosphorylates MDC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10556981", "map_id": "none", "name": "DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome:MDC1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10555565", "map_id": "none", "name": "DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome:p-5T-MDC1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10556989", "map_id": "none", "name": "ATM phosphorylates histone H2AFX on S139 at DNA DSBs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10556986", "map_id": "none", "name": "DNA DSBs:p-MRN:p-S-1981,Ac-K3016-ATM:KAT5:p-Y142-H2AFX-Nucleosome", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10555581", "map_id": "none", "name": "p-T68-CHEK2 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10555577", "map_id": "Q9U1Y5", "name": "phospho-chk-2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10555647", "map_id": "none", "name": "APBB1 and MAPK8 bind diphosphorylated H2AFX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10555643", "map_id": "Q9BKZ9", "name": "feh-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00001410", "map_id": "WBGene00001410", "name": "feh-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10555645", "map_id": "none", "name": "DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139,Y142-H2AFX-Nucleosome:APBB1:p-T,Y-MAPK8", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9BKZ9", "map_id": "Q9BKZ9", "name": "feh-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10556991", "map_id": "none", "name": "MDC1 associates with gamma-H2AFX at nuclear foci", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10556979", "map_id": "none", "name": "MDC1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10566033", "map_id": "none", "name": "COP9 and TOR1 deneddylate STON2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10566028", "map_id": "none", "name": "NEDD8-STONs:TOR1 hexamer:COP9", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P90761", "map_id": "P90761", "name": "unc-41", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006777", "map_id": "WBGene00006777", "name": "unc-41", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q95NU5", "map_id": "Q95NU5", "name": "ooc-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003870", "map_id": "WBGene00003870", "name": "ooc-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10566008", "map_id": "none", "name": "TOR1 hexamer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10565943", "map_id": "P90761", "name": "unc-41", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10556642", "map_id": "Q93725", "name": "ned-8", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10566256", "map_id": "none", "name": "AP-2 directly binds some endocytic cargo", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10566250", "map_id": "none", "name": "AP-2 cargo", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9XTT3", "map_id": "Q9XTT3", "name": "scav-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013039", "map_id": "WBGene00013039", "name": "scav-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10566252", "map_id": "none", "name": "AP-2:cargo", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10566254", "map_id": "none", "name": "AP2:chlorpromazine", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10566272", "map_id": "none", "name": "ARBB recruits GPCRs into clathrin-coated pits", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10566213", "map_id": "none", "name": "ARRB:ARRB-binding GPCRs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10565777", "map_id": "none", "name": "PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "G5ECQ3", "map_id": "G5ECQ3", "name": "sel-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004762", "map_id": "WBGene00004762", "name": "sel-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q20483", "map_id": "Q20483", "name": "gakh-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018516", "map_id": "WBGene00018516", "name": "gakh-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9TXS0", "map_id": "Q9TXS0", "name": "fcho-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018974", "map_id": "WBGene00018974", "name": "fcho-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9N489", "map_id": "Q9N489", "name": "ncap-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022453", "map_id": "WBGene00022453", "name": "ncap-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10566270", "map_id": "none", "name": "ARBBs:ARBB-binding GPCRs:clathrin-coated pit", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10566234", "map_id": "none", "name": "UNQLNs:UIM proteins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "G5EFF7", "map_id": "G5EFF7", "name": "ubql-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008852", "map_id": "WBGene00008852", "name": "ubql-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10566035", "map_id": "none", "name": "STON2 is neddylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10565990", "map_id": "P90761", "name": "unc-41", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10566371", "map_id": "none", "name": "PICALM binds R-SNAREs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10566365", "map_id": "Q9XZI6", "name": "unc-11", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00006751", "map_id": "WBGene00006751", "name": "unc-11", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10566363", "map_id": "none", "name": "VAMP2,3,8", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10566369", "map_id": "none", "name": "PICALM:VAMP2,3,8", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9XZI6", "map_id": "Q9XZI6", "name": "unc-11", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10573106", "map_id": "none", "name": "AP2 binds chlorpromazine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9648300", "map_id": "none", "name": "chlorpromazine", "type": "reactant", "sub_type": "other", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10566215", "map_id": "none", "name": "ARRB bind GPCRs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10521710", "map_id": "P51485", "name": "arr-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10566211", "map_id": "none", "name": "ARRB-binding GPCRs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10565949", "map_id": "none", "name": "STON2 binds SYT proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10565938", "map_id": "none", "name": "SYT dimers", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10565947", "map_id": "none", "name": "STON2,1:SYT dimers", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10566268", "map_id": "none", "name": "Epsin family proteins bind ubiquitinated cargo", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10566232", "map_id": "none", "name": "EPS15,EPN1,EPN2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10566264", "map_id": "none", "name": "EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10566266", "map_id": "none", "name": "EPS15,EPN1,EPN2:ubiquitinated cargo", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10566236", "map_id": "none", "name": "UBQLNs bind UIM-containing adaptor proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10566220", "map_id": "G5EFF7", "name": "ubql-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10565967", "map_id": "none", "name": "DAB2 binds LRP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10565951", "map_id": "A0A486WXX8", "name": "dab-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10565963", "map_id": "none", "name": "Homologues of LRP2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q21496", "map_id": "Q21496", "name": "LRP2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020010", "map_id": "WBGene00020010", "name": "LRP2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q21948", "map_id": "Q21948", "name": "LRP2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10565965", "map_id": "none", "name": "LRP2:DAB2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10566030", "map_id": "none", "name": "NEDD8-STON binds TOR1 hexamer and COP9 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10506050", "map_id": "none", "name": "CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_111628", "map_id": "CHEBI:15859", "name": "N-carb-L-Asp", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_76630", "map_id": "CHEBI:17025", "name": "(S)-DHO", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10506047", "map_id": "none", "name": "CAD hexamer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q18990", "map_id": "Q18990", "name": "pyr-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004259", "map_id": "WBGene00004259", "name": "pyr-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10506053", "map_id": "none", "name": "CAD hexamer transforms CAP to N-carb-L-Asp", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_111647", "map_id": "CHEBI:17672", "name": "CAP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_29448", "map_id": "CHEBI:29991", "name": "L-Asp", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10506056", "map_id": "none", "name": "CAD hexamer transforms L-Gln to CAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10506040", "map_id": "none", "name": "DHODH:FMN oxidises (S)-DHO to orotate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_76632", "map_id": "CHEBI:16742", "name": "ORO", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10506037", "map_id": "none", "name": "DHODH:FMN", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "O01815", "map_id": "O01815", "name": "dhod-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020932", "map_id": "WBGene00020932", "name": "dhod-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10506027", "map_id": "none", "name": "UMPS dimer decarboxylates OMP to UMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_111629", "map_id": "CHEBI:15842", "name": "OMP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10506024", "map_id": "none", "name": "UMPS dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "G5EDZ2", "map_id": "G5EDZ2", "name": "umps-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011559", "map_id": "WBGene00011559", "name": "umps-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10506030", "map_id": "none", "name": "UMPS dimer transfers phoshoribosyl group to ORO to form OMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10508834", "map_id": "none", "name": "Formation of phosphoribosyl pyrophosphate amidotransferase tetramer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10506404", "map_id": "none", "name": "PPAT dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q22134", "map_id": "Q22134", "name": "ppat-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011407", "map_id": "WBGene00011407", "name": "ppat-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:17909", "map_id": "CHEBI:17909", "name": "CHEBI:17909", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10508832", "map_id": "none", "name": "PPAT tetramer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_29602", "map_id": "CHEBI:17202", "name": "IMP", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "reaction_10508866", "map_id": "none", "name": "IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_35141", "map_id": "CHEBI:15919", "name": "ADS", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10508863", "map_id": "none", "name": "ADSS, ADSSL1 dimers", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P91134", "map_id": "P91134", "name": "adss-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016509", "map_id": "WBGene00016509", "name": "adss-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10508836", "map_id": "none", "name": "Dissociation of phosphoribosyl pyrophosphate amidotransferase tetramer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10506340", "map_id": "none", "name": "XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_111584", "map_id": "CHEBI:15652", "name": "XMP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10506337", "map_id": "Q09580", "name": "gmps-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00010912", "map_id": "WBGene00010912", "name": "gmps-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10506407", "map_id": "none", "name": "5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_111292", "map_id": "CHEBI:17284", "name": "PRA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10506376", "map_id": "none", "name": "SAICAR => AICAR + Fumarate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_111399", "map_id": "CHEBI:18319", "name": "SAICAR", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_111409", "map_id": "CHEBI:18406", "name": "AICAR", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10506373", "map_id": "none", "name": "ADSL tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q21774", "map_id": "Q21774", "name": "adsl-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011064", "map_id": "WBGene00011064", "name": "adsl-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10506409", "map_id": "none", "name": "adenylosuccinate => adenosine 5'-monophosphate + fumarate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10506352", "map_id": "none", "name": "IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10506347", "map_id": "none", "name": "IMPDH1 tetramer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10506350", "map_id": "none", "name": "IMPDH tetramers:IMPDH inhibitors", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10506386", "map_id": "none", "name": "CAIR + Aspartate + ATP => SAICAR + ADP + Pi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_111395", "map_id": "CHEBI:28413", "name": "CAIR", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10506383", "map_id": "none", "name": "PAICS octamer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q10457", "map_id": "Q10457", "name": "pacs-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00015116", "map_id": "WBGene00015116", "name": "pacs-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10506389", "map_id": "none", "name": "AIR + CO2 => CAIR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_111370", "map_id": "CHEBI:28843", "name": "AIR", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10506363", "map_id": "none", "name": "FAICAR => IMP + H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_111427", "map_id": "CHEBI:18381", "name": "FAICAR", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10506360", "map_id": "none", "name": "ATIC dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q95QQ4", "map_id": "Q95QQ4", "name": "atic-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016957", "map_id": "WBGene00016957", "name": "atic-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10558365", "map_id": "none", "name": "LHPP:Mg2+ dimer hydrolyses PPi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10558362", "map_id": "none", "name": "LHPP:Mg2+ dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "O01926", "map_id": "O01926", "name": "LHPP", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007548", "map_id": "WBGene00007548", "name": "LHPP", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10506397", "map_id": "none", "name": "FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_111354", "map_id": "CHEBI:18272", "name": "N-Formyl-GAR", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_111369", "map_id": "CHEBI:18413", "name": "FGAM", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10506394", "map_id": "Q19311", "name": "pfas-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00008654", "map_id": "WBGene00008654", "name": "pfas-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10573084", "map_id": "none", "name": "IMPDH tetramers binds IMPDH inhibitors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9678719", "map_id": "none", "name": "IMPDH inhibitors", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10506366", "map_id": "none", "name": "AICAR + 10-Formyl-THF => FAICAR + THF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_419151", "map_id": "CHEBI:15637", "name": "10-formyl-THF", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10573092", "map_id": "none", "name": "ITGA4:ITGB1 binds natalizumab", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10514207", "map_id": "none", "name": "ITGA4:ITGB1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_9679737", "map_id": "none", "name": "natalizumab", "type": "reactant", "sub_type": "other", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10573090", "map_id": "none", "name": "ITGA4:ITGB1:natalizumab", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10515321", "map_id": "none", "name": "Integrin alpha5beta1 binds FN1 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10515317", "map_id": "none", "name": "Integrin alpha5beta1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10515313", "map_id": "none", "name": "FN1 dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10515319", "map_id": "none", "name": "Integrin alpha5beta1:FN1 dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10515290", "map_id": "none", "name": "MERTK receptor binds ligands (Gas6 or Protein S)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10515286", "map_id": "none", "name": "Homologues of 11xCbxE-GAS6(39-691)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10515280", "map_id": "Q9XVQ7", "name": "MERTK", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10515288", "map_id": "none", "name": "MERTK:MERKT ligands", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10545950", "map_id": "none", "name": "E-selectin binds E-selectin ligand", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10545946", "map_id": "Q19459", "name": "GLG1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "WBGene00008800", "map_id": "WBGene00008800", "name": "GLG1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10545941", "map_id": "none", "name": "Homologues of SELE", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10545948", "map_id": "none", "name": "2xSELE ligands:SELE", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q19459", "map_id": "Q19459", "name": "GLG1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10572733", "map_id": "none", "name": "SERPING1 is secreted", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_10572731", "map_id": "none", "name": "Homologues of SERPING1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "species_10526610", "map_id": "none", "name": "Homologues of SERPING1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10509775", "map_id": "none", "name": "SERPINC1 binds SERPINC1 activators", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10509755", "map_id": "none", "name": "Homologues of SERPINC1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_9693058", "map_id": "none", "name": "SERPINC1 activators", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10509773", "map_id": "none", "name": "SERPINC1:SERPINC1 activators", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10566692", "map_id": "none", "name": "PAFAH2 hydrolyses PAF to lyso-PAF and acetate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_8869207", "map_id": "CHEBI:91144", "name": "lyso-PAF", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10566689", "map_id": "none", "name": "Homologues of PAFAH2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "G5EGT1", "map_id": "G5EGT1", "name": "paf-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003906", "map_id": "WBGene00003906", "name": "paf-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q22943", "map_id": "Q22943", "name": "paf-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003907", "map_id": "WBGene00003907", "name": "paf-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10523812", "map_id": "none", "name": "Fgr may phosphorylate p38 MAPK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10523809", "map_id": "none", "name": "Homologues of FGR", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10509648", "map_id": "none", "name": "Phosphorylation of Platelet Sec-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10509637", "map_id": "none", "name": "Homologues of STXBP3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10509645", "map_id": "none", "name": "Homologues of p-STXBP3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10509553", "map_id": "none", "name": "Activated conventional protein kinase C", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10509555", "map_id": "none", "name": "Activation of conventional Protein Kinase C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10526786", "map_id": "none", "name": "Surface deployment of platelet dense granule membrane components", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10526770", "map_id": "none", "name": "Platelet dense granule membrane components", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_114584", "compartment_display": "platelet dense granule membrane", "complex": "true" }, { "id": "species_10526784", "map_id": "none", "name": "Platelet dense granule membrane components", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10526658", "map_id": "none", "name": "Exocytosis of platelet alpha granule contents", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10526516", "map_id": "none", "name": "Platelet alpha granule contents", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_114506", "compartment_display": "platelet alpha granule lumen", "complex": "true" }, { "id": "Q09387", "map_id": "Q09387", "name": "FAM49B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019944", "map_id": "WBGene00019944", "name": "FAM49B", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q21154", "map_id": "Q21154", "name": "moma-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019333", "map_id": "WBGene00019333", "name": "moma-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q18685", "map_id": "Q18685", "name": "unc-112", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006836", "map_id": "WBGene00006836", "name": "unc-112", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q18245", "map_id": "Q18245", "name": "ISLR", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007764", "map_id": "WBGene00007764", "name": "ISLR", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q23580", "map_id": "Q23580", "name": "lron-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022789", "map_id": "WBGene00022789", "name": "lron-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9GZE9", "map_id": "Q9GZE9", "name": "ldp-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017719", "map_id": "WBGene00017719", "name": "ldp-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XXG5", "map_id": "Q9XXG5", "name": "tor-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006598", "map_id": "WBGene00006598", "name": "tor-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O45271", "map_id": "O45271", "name": "tor-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006597", "map_id": "WBGene00006597", "name": "tor-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q22174", "map_id": "Q22174", "name": "GTPBP2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011449", "map_id": "WBGene00011449", "name": "GTPBP2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P91917", "map_id": "P91917", "name": "ola-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012344", "map_id": "WBGene00012344", "name": "ola-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10526656", "map_id": "none", "name": "Platelet alpha granule contents", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10523396", "map_id": "none", "name": "ABCC4 accumulation of dense granule contents", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_114584", "compartment_display": "platelet dense granule membrane" }, { "id": "species_114565", "map_id": "CHEBI:456216", "name": "ADP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_114524", "compartment_display": "platelet dense granule lumen", "complex": "false" }, { "id": "species_10523393", "map_id": "Q19625", "name": "mrp-6", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_114584", "compartment_display": "platelet dense granule membrane", "complex": "false" }, { "id": "reaction_10526744", "map_id": "none", "name": "Exocytosis of platelet dense granule content", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10526706", "map_id": "none", "name": "Platelet dense granule content", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_114524", "compartment_display": "platelet dense granule lumen", "complex": "true" }, { "id": "H2L0F2", "map_id": "H2L0F2", "name": "CDC37L1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019497", "map_id": "WBGene00019497", "name": "CDC37L1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O16454", "map_id": "O16454", "name": "tag-196", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007055", "map_id": "WBGene00007055", "name": "tag-196", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q688B0", "map_id": "Q688B0", "name": "FAM3C", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019786", "map_id": "WBGene00019786", "name": "FAM3C", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10526742", "map_id": "none", "name": "Platelet dense granule content", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10526856", "map_id": "none", "name": "Surface deployment of platelet alpha granule membrane components", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10526830", "map_id": "none", "name": "Platelet alpha granule membrane components that are released on degranulation", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_114510", "compartment_display": "platelet alpha granule membrane", "complex": "true" }, { "id": "Q9N4L6", "map_id": "Q9N4L6", "name": "TMX3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022836", "map_id": "WBGene00022836", "name": "TMX3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XVI4", "map_id": "Q9XVI4", "name": "tsp-7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006633", "map_id": "WBGene00006633", "name": "tsp-7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34616", "map_id": "P34616", "name": "cdh-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000395", "map_id": "WBGene00000395", "name": "cdh-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "U4PMB9", "map_id": "U4PMB9", "name": "fmil-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021362", "map_id": "WBGene00021362", "name": "fmil-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O16522", "map_id": "O16522", "name": "CYB5R1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020267", "map_id": "WBGene00020267", "name": "CYB5R1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P91855", "map_id": "P91855", "name": "PHACTR2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009174", "map_id": "WBGene00009174", "name": "PHACTR2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10526854", "map_id": "none", "name": "Platelet alpha granule membrane components that are released on degranulation", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10518043", "map_id": "none", "name": "Exocytosis of Proactivator polypeptide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_10518035", "map_id": "none", "name": "PSAP,CHID1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "true" }, { "id": "Q18607", "map_id": "Q18607", "name": "chil-10", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016642", "map_id": "WBGene00016642", "name": "chil-10", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10518041", "map_id": "none", "name": "PSAP,CHID1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10527071", "map_id": "none", "name": "Release of platelet cytosolic components", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10526977", "map_id": "none", "name": "Platelet releasate cytosolic proteins", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "H2KYR1", "map_id": "H2KYR1", "name": "vig-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006924", "map_id": "WBGene00006924", "name": "vig-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P52274", "map_id": "P52274", "name": "tba-8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006534", "map_id": "WBGene00006534", "name": "tba-8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "H2L2E8", "map_id": "H2L2E8", "name": "tba-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006528", "map_id": "WBGene00006528", "name": "tba-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P91910", "map_id": "P91910", "name": "mec-12", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003175", "map_id": "WBGene00003175", "name": "mec-12", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O18154", "map_id": "O18154", "name": "tba-7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006533", "map_id": "WBGene00006533", "name": "tba-7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34690", "map_id": "P34690", "name": "tba-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006529", "map_id": "WBGene00006529", "name": "tba-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EDD4", "map_id": "G5EDD4", "name": "tba-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006530", "map_id": "WBGene00006530", "name": "tba-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O17939", "map_id": "O17939", "name": "aipl-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010685", "map_id": "WBGene00010685", "name": "aipl-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q09936", "map_id": "Q09936", "name": "TAGLN2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016898", "map_id": "WBGene00016898", "name": "TAGLN2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q23050", "map_id": "Q23050", "name": "clik-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020808", "map_id": "WBGene00020808", "name": "clik-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O44788", "map_id": "O44788", "name": "cpn-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000778", "map_id": "WBGene00000778", "name": "cpn-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q20318", "map_id": "Q20318", "name": "lin-49", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003034", "map_id": "WBGene00003034", "name": "lin-49", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9N3B0", "map_id": "Q9N3B0", "name": "manf-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021888", "map_id": "WBGene00021888", "name": "manf-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10527069", "map_id": "none", "name": "Platelet releasate cytosolic proteins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10509664", "map_id": "none", "name": "PLC gamma 2-mediated PIP2 hydrolysis", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10509661", "map_id": "Q22070", "name": "phospho-plc-3", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10524321", "map_id": "none", "name": "VAV3 is a GEF for Rho/Rac family kinases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10524313", "map_id": "none", "name": "VAV3 Rho/Rac effectors:GDP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10524315", "map_id": "none", "name": "VAV3 Rho/Rac effectors:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10524318", "map_id": "Q45FX5", "name": "phospho-vav-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10523412", "map_id": "none", "name": "SLP-76 stimulates PLC gamma 2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10523410", "map_id": "Q22070", "name": "plc-3", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10524309", "map_id": "none", "name": "VAV2 is a GEF for Rho/Rac family kinases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10524301", "map_id": "none", "name": "VAV2 Rho/Rac effectors:GDP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10524303", "map_id": "none", "name": "VAV2 Rho/Rac effectors:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10524295", "map_id": "none", "name": "VAV1 is a GEF for Rho/Rac family GTPases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10524283", "map_id": "none", "name": "VAV1 Rho/Rac effectors:GDP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10524285", "map_id": "none", "name": "VAV1 Rho/Rac effectors:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10524288", "map_id": "Q45FX5", "name": "phospho-vav-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10524293", "map_id": "none", "name": "PIP3:VAV1,2,3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10524291", "map_id": "none", "name": "VAV family:PIP2", "type": "inhibitor", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10524234", "map_id": "none", "name": "PI3K alpha, beta, gamma convert PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10521714", "map_id": "none", "name": "F2R binds ARRB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10521705", "map_id": "H2KZ99", "name": "gnrr-4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10521712", "map_id": "none", "name": "F2R:ARRB1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10509539", "map_id": "none", "name": "Thrombin-activated PARs activate G12/13", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10509526", "map_id": "none", "name": "Thrombin activated PAR:G12/13 (inactive)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10509536", "map_id": "none", "name": "Thrombin activated PAR:G12/13 (active)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10509512", "map_id": "H2KZ99", "name": "gnrr-4", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10521731", "map_id": "none", "name": "F2R binds ARRB2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10521729", "map_id": "none", "name": "F2R:ARRB2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10521092", "map_id": "none", "name": "Thrombin-activated PARs binds G-protein Gq", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10509561", "map_id": "none", "name": "Thrombin-activated PARs:Gq (inactive)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10521094", "map_id": "none", "name": "Thrombin-activated PARs:Gq (active) dissociate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10509563", "map_id": "none", "name": "Thrombin-activated PAR:Gq (active)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10521718", "map_id": "none", "name": "SRC-1 is activated (in F2R:ARRB1:MAPKs:SRC-1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10521716", "map_id": "none", "name": "F2R:ARRB1:MAPKs:SRC-1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10521735", "map_id": "none", "name": "F2R:ARRB2 binds MAPKs, SRC-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10521733", "map_id": "none", "name": "F2R:ARRB2:MAPKs:SRC-1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10521737", "map_id": "none", "name": "SRC-1 bound to ARRB2 is not activated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10521098", "map_id": "none", "name": "Thrombin-activated PARs:G12/13 (active) dissociate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10521723", "map_id": "none", "name": "Activated SRC-1 activates MAPKs (in F2R:ARRB1:MAPKs:active SRC-1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10521720", "map_id": "none", "name": "F2R:ARRB1:active MAPKs:active SRC-1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10509565", "map_id": "none", "name": "Thrombin-activated PARs activate Gq", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10521725", "map_id": "none", "name": "F2R:ARRB1 binds MAPKs, SRC-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10528130", "map_id": "none", "name": "F-actin capping protein is a heterodimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10528126", "map_id": "P34686", "name": "cap-2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10528121", "map_id": "P34685", "name": "cap-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10528128", "map_id": "none", "name": "F-actin capping protein", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10531587", "map_id": "none", "name": "Kinesin-5 is a homotetramer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10531494", "map_id": "G5ECF4", "name": "bmk-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00000257", "map_id": "WBGene00000257", "name": "bmk-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10531496", "map_id": "none", "name": "Kinesin-5 homotetramer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "G5ECF4", "map_id": "G5ECF4", "name": "bmk-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10531589", "map_id": "none", "name": "Kinesin-6 and RACGAP1 form the heterotetrameric complex centralspindlin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10531503", "map_id": "Q9XUS9", "name": "cyk-4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00000875", "map_id": "WBGene00000875", "name": "cyk-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10531498", "map_id": "Q8MQ03", "name": "zen-4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10531505", "map_id": "none", "name": "Centralspindlin", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q8MQ03", "map_id": "Q8MQ03", "name": "zen-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XUS9", "map_id": "Q9XUS9", "name": "cyk-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10531464", "map_id": "none", "name": "Kinesin-1 is a heterotetramer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10531453", "map_id": "none", "name": "KLC1,KLC2,KLC3,KLC4", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P46822", "map_id": "P46822", "name": "klc-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002215", "map_id": "WBGene00002215", "name": "klc-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "H9G2T2", "map_id": "H9G2T2", "name": "klc-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002214", "map_id": "WBGene00002214", "name": "klc-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10531458", "map_id": "P34540", "name": "unc-116", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00006840", "map_id": "WBGene00006840", "name": "unc-116", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10531462", "map_id": "none", "name": "Kinesin-1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P34540", "map_id": "P34540", "name": "unc-116", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10531593", "map_id": "none", "name": "Kinesin-3 is a dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10531591", "map_id": "none", "name": "Kinesin-3 monomers", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10531489", "map_id": "none", "name": "Kinesin-3 dimers", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10531595", "map_id": "none", "name": "Kinesin-13 is a dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10531521", "map_id": "Q9XU12", "name": "klp-7", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00002219", "map_id": "WBGene00002219", "name": "klp-7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10531529", "map_id": "none", "name": "Kinesin-13 dimers", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9XU12", "map_id": "Q9XU12", "name": "klp-7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10531636", "map_id": "none", "name": "HP1 alpha binds Histone H3K9(me)3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10531624", "map_id": "P34618", "name": "cec-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10531632", "map_id": "none", "name": "Histone H3 methylated at lysine-9", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10531634", "map_id": "none", "name": "HP1alpha:Histone H3 methylated at K9", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10566148", "map_id": "none", "name": "MICAL1 produces NADP+, H2O2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10566145", "map_id": "none", "name": "MICAL1:FAD", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "A0A061AD47", "map_id": "A0A061AD47", "name": "tag-273", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013289", "map_id": "WBGene00013289", "name": "tag-273", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10531622", "map_id": "none", "name": "Dual-specific AKAPs bind type I and II PKA regulatory subunits", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10531618", "map_id": "none", "name": "Dual-specific AKAPs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q10955", "map_id": "Q10955", "name": "rgs-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004348", "map_id": "WBGene00004348", "name": "rgs-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q09285", "map_id": "Q09285", "name": "akap-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016977", "map_id": "WBGene00016977", "name": "akap-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10531620", "map_id": "none", "name": "Dual-specific AKAPs:PKA tetramer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10531606", "map_id": "none", "name": "Mitofusins trans-interact linking mitochondria prior to fusion", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane" }, { "id": "species_10531600", "map_id": "Q23424", "name": "fzo-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "false" }, { "id": "species_10531604", "map_id": "none", "name": "Mitofusin complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "true" }, { "id": "reaction_10531750", "map_id": "none", "name": "Rabenosyn-5 connects Rab5 to VPS-45", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_74700", "compartment_display": "endosome membrane" }, { "id": "species_10531741", "map_id": "P91857", "name": "rab-5", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "false" }, { "id": "species_10531705", "map_id": "W6SBE5", "name": "rabs-5", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "false" }, { "id": "WBGene00021538", "map_id": "WBGene00021538", "name": "rabs-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10531746", "map_id": "H2KYN0", "name": "vps-45", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "false" }, { "id": "WBGene00016643", "map_id": "WBGene00016643", "name": "vps-45", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10531748", "map_id": "none", "name": "Rabenosyn-5:VPS-45", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "true" }, { "id": "H2KYN0", "map_id": "H2KYN0", "name": "vps-45", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "W6SBE5", "map_id": "W6SBE5", "name": "rabs-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10531739", "map_id": "none", "name": "DOCKs bind to RhoGEFs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10531735", "map_id": "none", "name": "RAC1, CDC42", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10531733", "map_id": "none", "name": "DOCK-GEFs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "A0A0K3AR51", "map_id": "A0A0K3AR51", "name": "DOCK11", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "F22G12.5c", "map_id": "F22G12.5c", "name": "DOCK11", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q20487", "map_id": "Q20487", "name": "DOCK6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10531737", "map_id": "none", "name": "DOCK-GEFs:RAC1, CDC42", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10531645", "map_id": "none", "name": "LRRC16A binds F-actin capping protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10531641", "map_id": "Q21301", "name": "crml-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00010641", "map_id": "WBGene00010641", "name": "crml-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10531643", "map_id": "none", "name": "LRRC16A:F-actin capping protein", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q21301", "map_id": "Q21301", "name": "crml-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10531709", "map_id": "none", "name": "EHD proteins interact with Rabenosyn-5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_74700", "compartment_display": "endosome membrane" }, { "id": "species_10531696", "map_id": "G5ECC3", "name": "rme-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "false" }, { "id": "WBGene00004373", "map_id": "WBGene00004373", "name": "rme-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10531707", "map_id": "none", "name": "C-terminal EH domain containing proteins:Rabenosyn-5", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "true" }, { "id": "G5ECC3", "map_id": "G5ECC3", "name": "rme-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10532193", "map_id": "none", "name": "Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10532190", "map_id": "none", "name": "hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1:LIMD1,AJUBA,WTIP:PHD2,3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "G5EBV0", "map_id": "G5EBV0", "name": "egl-9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001178", "map_id": "WBGene00001178", "name": "egl-9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10532164", "map_id": "none", "name": "ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1:LIMD1,AJUBA,WTIF:PHD2,3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10532259", "map_id": "none", "name": "Nuclear VBC complex ubiquitinylates HIF-alpha", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10532252", "map_id": "none", "name": "UBE2D1,2,3:Ubiquitin", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10532246", "map_id": "none", "name": "hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10532256", "map_id": "none", "name": "ub-HIF-alpha:VHL:EloB,C:CUL2:RBX1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10532262", "map_id": "none", "name": "Cytosolic PHD2,3 hydroxylates proline residues on HIF3A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10532176", "map_id": "G5EGD2", "name": "hif-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10532141", "map_id": "G5EGD2", "name": "hif-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10532162", "map_id": "none", "name": "PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10532214", "map_id": "none", "name": "Nuclear PHD1,3 hydroxylates proline residues on HIF3A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10532182", "map_id": "G5EGD2", "name": "hif-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10532201", "map_id": "G5EGD2", "name": "hif-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10532211", "map_id": "none", "name": "PHD1,3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10532248", "map_id": "none", "name": "Nuclear VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10532234", "map_id": "G5EGD2", "name": "hif-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10532244", "map_id": "none", "name": "VHL:EloB,C:CUL2:RBX1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10532264", "map_id": "none", "name": "ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10532145", "map_id": "none", "name": "ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10532266", "map_id": "none", "name": "Cytosolic PHD2,3 hydroxylates proline residues on HIF1A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10532138", "map_id": "G5EGD2", "name": "hif-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10532170", "map_id": "none", "name": "Proteasome proteolyzes ub-HIF-alpha", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10532166", "map_id": "none", "name": "ub-hydroxyPro-HIF-alpha:VCB (with or without LIMD1)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10532168", "map_id": "none", "name": "VBC complex (with or without LIMD1)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10532268", "map_id": "none", "name": "Nuclear PHD1,3 hydroxylates proline residues on HIF1A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10532180", "map_id": "G5EGD2", "name": "hif-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10532236", "map_id": "G5EGD2", "name": "hif-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10532270", "map_id": "none", "name": "Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10521058", "map_id": "none", "name": "Rap1 signal termination by Rap1GAPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10521051", "map_id": "none", "name": "Rap1 GTPase-activating proteins", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "H2L2C2", "map_id": "H2L2C2", "name": "sipa-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012100", "map_id": "WBGene00012100", "name": "sipa-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "H2L055", "map_id": "H2L055", "name": "phospho-p-S7-RAP1GAP2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018734", "map_id": "WBGene00018734", "name": "phospho-p-S7-RAP1GAP2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10521056", "map_id": "none", "name": "RAP1GAP2:14-3-3beta, zeta", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10521090", "map_id": "none", "name": "Rap1 sequesters Raf1 to inhibit ERK cascade", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10521088", "map_id": "none", "name": "Rap1-GTP:Raf1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10528644", "map_id": "none", "name": "14-3-3 proteins beta and zeta bind and inhibit Rap1Gap2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10521054", "map_id": "none", "name": "14-3-3 beta, zeta", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10521049", "map_id": "H2L055", "name": "RAP1GAP2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10528642", "map_id": "H2L055", "name": "phospho-p-S7-RAP1GAP2", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10521081", "map_id": "none", "name": "Activation of EPACs by cAMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10528655", "map_id": "none", "name": "PKA/PKG phosphorylate Rap1GAP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10528652", "map_id": "none", "name": "PKA catalytic subunits, PKG type I", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10531425", "map_id": "none", "name": "Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_983032", "map_id": "CHEBI:25676", "name": "oligopeptide fragment (8-16aa)", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10531422", "map_id": "none", "name": "IFN gamma stimulated aminopeptidases", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q4TT88", "map_id": "Q4TT88", "name": "pam-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003914", "map_id": "WBGene00003914", "name": "pam-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9NAA0", "map_id": "Q9NAA0", "name": "ERAP1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022073", "map_id": "WBGene00022073", "name": "ERAP1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A5A631", "map_id": "A5A631", "name": "ERAP1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EGH4", "map_id": "G5EGH4", "name": "ERAP1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "H2L0M5", "map_id": "H2L0M5", "name": "ERAP1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q22317", "map_id": "Q22317", "name": "anp-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011587", "map_id": "WBGene00011587", "name": "anp-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q09541", "map_id": "Q09541", "name": "tpp-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017686", "map_id": "WBGene00017686", "name": "tpp-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10531346", "map_id": "none", "name": "Polyubiquitination of substrate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10531247", "map_id": "none", "name": "Ubiquitin:E2 conjugating enzymes", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10531253", "map_id": "none", "name": "E3:Ub:substrate", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "O62235", "map_id": "O62235", "name": "rbpl-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009477", "map_id": "WBGene00009477", "name": "rbpl-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9N4I6", "map_id": "Q9N4I6", "name": "ZNRF2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022115", "map_id": "WBGene00022115", "name": "ZNRF2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "L8E6Y3", "map_id": "L8E6Y3", "name": "unk-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016407", "map_id": "WBGene00016407", "name": "unk-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P91133", "map_id": "P91133", "name": "ubr-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016326", "map_id": "WBGene00016326", "name": "ubr-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "B1Q249", "map_id": "B1Q249", "name": "RNF19B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00015926", "map_id": "WBGene00015926", "name": "RNF19B", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9UAQ3", "map_id": "Q9UAQ3", "name": "madd-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016539", "map_id": "WBGene00016539", "name": "madd-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q20871", "map_id": "Q20871", "name": "RNF19A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021721", "map_id": "WBGene00021721", "name": "RNF19A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q20874", "map_id": "Q20874", "name": "RNF19A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A8DJA6", "map_id": "A8DJA6", "name": "RNF19A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10531245", "map_id": "none", "name": "E2 Ubiquitin-conjugating enzyme", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10531312", "map_id": "none", "name": "E3:K48-polyubiquitinated substrate", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10531314", "map_id": "none", "name": "Release of E3 from polyubiquitinated substrate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_983123", "map_id": "none", "name": "K48polyUb-antigenic substrate", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10531179", "map_id": "none", "name": "E3 ligases in proteasomal degradation", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10531348", "map_id": "none", "name": "Interaction of E3 with substrate and E2-Ub complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_983035", "map_id": "none", "name": "antigenic substrate", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10531249", "map_id": "none", "name": "Ag-substrate:E3:E2:Ub", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10531316", "map_id": "none", "name": "Proteasomal cleavage of substrate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10531256", "map_id": "none", "name": "Transfer of Ub from E2 to substrate and release of E2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10531340", "map_id": "none", "name": "Transfer of ubiquitin from E1 to E2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10531337", "map_id": "none", "name": "E1 bound ubiquitin", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10531335", "map_id": "none", "name": "Ubiquitin activating E1 enzymes", "type": "catalyst", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10531343", "map_id": "none", "name": "E1 mediated ubiquitin activation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10531399", "map_id": "none", "name": "Trimming of peptides in ER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_983034", "map_id": "CHEBI:25676", "name": "oligopeptide fragment", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_8943716", "map_id": "CHEBI:59869", "name": "L-amino acid", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_983033", "map_id": "CHEBI:25676", "name": "Antigen peptide", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10531396", "map_id": "none", "name": "ERAP1/2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "reaction_10531304", "map_id": "none", "name": "Transport of Antigen peptide in to ER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_10531301", "map_id": "none", "name": "TAP", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q9U275", "map_id": "Q9U275", "name": "haf-7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001817", "map_id": "WBGene00001817", "name": "haf-7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O02086", "map_id": "O02086", "name": "haf-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001812", "map_id": "WBGene00001812", "name": "haf-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O18227", "map_id": "O18227", "name": "haf-8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001818", "map_id": "WBGene00001818", "name": "haf-8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O44897", "map_id": "O44897", "name": "haf-9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001819", "map_id": "WBGene00001819", "name": "haf-9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9TZD9", "map_id": "Q9TZD9", "name": "haf-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001814", "map_id": "WBGene00001814", "name": "haf-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10515960", "map_id": "none", "name": "Coat Assembly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10515958", "map_id": "none", "name": "SAR1B:GTP:SEC23:SEC24", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10543540", "map_id": "none", "name": "Reduction of disulphide bonds in MHC II antigens", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_2213221", "map_id": "none", "name": "Antigen", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_2213225", "map_id": "none", "name": "unfolded antigen", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_10543537", "map_id": "P34276", "name": "IFI30", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "WBGene00015336", "map_id": "WBGene00015336", "name": "IFI30", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10542853", "map_id": "none", "name": "MHC class II antigen processing", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_2213226", "map_id": "none", "name": "MHC class II epitopes", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_10542850", "map_id": "none", "name": "Cathepsin", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "true" }, { "id": "reaction_10531914", "map_id": "none", "name": "PRKCB (Protein kinase C beta, PKC-beta) binds diacylglycerol and phosphatidylserine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10509541", "map_id": "P90980", "name": "pkc-2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10509549", "map_id": "none", "name": "Activated PKC beta", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10531939", "map_id": "none", "name": "p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10531936", "map_id": "none", "name": "p-RASGRP1,3:DAG", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10520805", "map_id": "none", "name": "Dephosphorylation of AKT by PP2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10537056", "map_id": "none", "name": "PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10537312", "map_id": "none", "name": "PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_1806276", "map_id": "CHEBI:17283", "name": "PI3P", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10537307", "map_id": "none", "name": "INPP4A/B", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q21623", "map_id": "Q21623", "name": "INPP4B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010975", "map_id": "WBGene00010975", "name": "INPP4B", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10537153", "map_id": "none", "name": "PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_1806224", "map_id": "CHEBI:16851", "name": "PI(3,5)P2", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10537150", "map_id": "none", "name": "SYNJs,OCRL", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10537283", "map_id": "none", "name": "PI3P is phosphorylated to PI(3,5)P2 by PIP5K1A/B at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10537317", "map_id": "none", "name": "PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10537314", "map_id": "none", "name": "SYNJ/INPP5(1)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "G5EGN9", "map_id": "G5EGN9", "name": "inpp-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012016", "map_id": "WBGene00012016", "name": "inpp-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10537126", "map_id": "none", "name": "PI is phosphorylated to PI5P by PIP5K1A/B at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10537222", "map_id": "none", "name": "PI4P is dephosphorylated to PI by SYNJ at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10563656", "map_id": "none", "name": "MTMR6 binds MTMR9", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10563629", "map_id": "Q965W9", "name": "mtm-9", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00003479", "map_id": "WBGene00003479", "name": "mtm-9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10537228", "map_id": "G5ED68", "name": "mtm-6", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "F53A2.8a", "map_id": "F53A2.8a", "name": "mtm-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10563654", "map_id": "none", "name": "MTMR6:MTMR9", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "G5ED68", "map_id": "G5ED68", "name": "mtm-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q965W9", "map_id": "Q965W9", "name": "mtm-9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10537291", "map_id": "none", "name": "PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10537288", "map_id": "none", "name": "PIP4K2/5K1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10563661", "map_id": "none", "name": "PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10563658", "map_id": "none", "name": "MTMR6:MTMR9,MTMR8:MTMR9", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10537325", "map_id": "none", "name": "PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10537230", "map_id": "none", "name": "MTM1,MTMR1,MTMR3,MTMR6,MTMR14,SYNJ1,SYNJ2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9N589", "map_id": "Q9N589", "name": "mtm-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003475", "map_id": "WBGene00003475", "name": "mtm-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10537101", "map_id": "none", "name": "PI is phosphorylated to PI4P by PI4K2A/B at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10537098", "map_id": "none", "name": "PI4K2A/2B", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10537294", "map_id": "none", "name": "PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10537264", "map_id": "none", "name": "PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10537261", "map_id": "none", "name": "PIK3(2)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10563633", "map_id": "none", "name": "MTMR8 binds MTMR9", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10563624", "map_id": "G5ED68", "name": "mtm-6", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10563631", "map_id": "none", "name": "MTMR8:MTMR9", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10537233", "map_id": "none", "name": "PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10563664", "map_id": "none", "name": "PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10567095", "map_id": "none", "name": "PLEKHA3,8 bind PI4P, ARF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10567091", "map_id": "Q9BKS2", "name": "PLEKHA8", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "WBGene00022347", "map_id": "WBGene00022347", "name": "PLEKHA8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10517985", "map_id": "G5EFK4", "name": "arf-3", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "species_10567093", "map_id": "none", "name": "ARF1:PLEKHA3,8:PI4P", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "Q9BKS2", "map_id": "Q9BKS2", "name": "PLEKHA8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10537244", "map_id": "none", "name": "PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10537241", "map_id": "none", "name": "PIK3C(1)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10537215", "map_id": "none", "name": "PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10537212", "map_id": "none", "name": "INPP5(2)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10509393", "map_id": "none", "name": "DSIF complex binds to RNA Pol II (hypophosphorylated)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10509356", "map_id": "none", "name": "RNA Pol II (hypophosphorylated):capped pre-mRNA complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10509234", "map_id": "none", "name": "DSIF complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10509358", "map_id": "none", "name": "RNA Pol II (hypophosphorylated) complex bound to DSIF protein", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10509363", "map_id": "none", "name": "Hypophosphorylation of RNA Pol II CTD by FCP1P protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10509239", "map_id": "Q9XUM4", "name": "CTDP1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10509381", "map_id": "none", "name": "Separation of elongating transcript from template", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10509377", "map_id": "none", "name": "Elongation complex prior to separation", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9TXQ9", "map_id": "Q9TXQ9", "name": "eaf-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017011", "map_id": "WBGene00017011", "name": "eaf-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34703", "map_id": "P34703", "name": "emb-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001259", "map_id": "WBGene00001259", "name": "emb-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EBY0", "map_id": "G5EBY0", "name": "rtfo-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009103", "map_id": "WBGene00009103", "name": "rtfo-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q03560", "map_id": "Q03560", "name": "ctr-9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007184", "map_id": "WBGene00007184", "name": "ctr-9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P90783", "map_id": "P90783", "name": "pafo-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008338", "map_id": "WBGene00008338", "name": "pafo-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q19375", "map_id": "Q19375", "name": "IWS1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008729", "map_id": "WBGene00008729", "name": "IWS1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10509379", "map_id": "none", "name": "Elongation complex with separated and uncleaved transcript", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10509367", "map_id": "none", "name": "Addition of nucleotides leads to transcript elongation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10509350", "map_id": "none", "name": "Elongation complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10509365", "map_id": "none", "name": "Processive elongation complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10509399", "map_id": "none", "name": "Pol II elongation complex moves on the template as transcript elongates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10509352", "map_id": "none", "name": "Recruitment of elongation factors to form elongation complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10509343", "map_id": "Q19375", "name": "IWS1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10509259", "map_id": "none", "name": "Early elongation complex with hyperphosphorylated Pol II CTD", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10509338", "map_id": "none", "name": "PAF1C", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10509306", "map_id": "none", "name": "Elongin Complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10509271", "map_id": "none", "name": "Homologues of TCEA1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10509348", "map_id": "P34703", "name": "emb-5", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10510498", "map_id": "none", "name": "OCTN2 / SLC22A5 transports CAR from extracellular space to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10510495", "map_id": "none", "name": "Homologues of SLC22A5", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10514514", "map_id": "none", "name": "palmitoylcarnitine + CoASH => palmitoyl-CoA + carnitine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane" }, { "id": "species_201050", "map_id": "CHEBI:17490", "name": "L-PCARN", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_201023", "map_id": "CHEBI:17126", "name": "CAR", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_77281", "map_id": "CHEBI:15525", "name": "PalmCoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10514511", "map_id": "G5ECS9", "name": "cpt-2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "WBGene00011122", "map_id": "WBGene00011122", "name": "cpt-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10514597", "map_id": "none", "name": "Exchange of palmitoylcarnitine and carnitine across the inner mitochondrial membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space" }, { "id": "species_10514594", "map_id": "Q27257", "name": "dif-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "WBGene00000996", "map_id": "WBGene00000996", "name": "dif-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10567572", "map_id": "none", "name": "Btn-ACACB:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10514577", "map_id": "none", "name": "Btn-ACACB:2Mn2+ polymer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "true" }, { "id": "reaction_10507418", "map_id": "none", "name": "Btn-ACACA:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10507415", "map_id": "none", "name": "Btn-ACACA:2Mn2+ polymer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10514589", "map_id": "none", "name": "pAMPK inactivates ACACB, inhibiting malonyl-CoA synthesis", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10514584", "map_id": "none", "name": "Btn-p-S79-ACACB:2Mn2+ polymer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "true" }, { "id": "species_10514586", "map_id": "none", "name": "AMPK heterotrimer (active)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10554146", "map_id": "none", "name": "RAB11A:GTP-containing Golgi vesicles recruit RAB3IP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13949", "compartment_display": "Golgi-associated vesicle membrane" }, { "id": "species_10554142", "map_id": "none", "name": "RAB11A:GTP:Golgi derived vesicle", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_13949", "compartment_display": "Golgi-associated vesicle membrane", "complex": "true" }, { "id": "species_10554144", "map_id": "none", "name": "RAB3IP:RAB11A:GTP:Golgi-derived vesicle", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_13949", "compartment_display": "Golgi-associated vesicle membrane", "complex": "true" }, { "id": "reaction_10517298", "map_id": "none", "name": "Collagen type I binds integrin alpha11beta1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10517294", "map_id": "none", "name": "Integrin alpha11beta1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10517296", "map_id": "none", "name": "Collagen type I:Mg2+:Integrin alpha 11 beta 1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10549011", "map_id": "none", "name": "Endostatin binds integrin alphaVbeta3, alphaVbeta5, alpha3beta1, alpha5beta1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10549007", "map_id": "none", "name": "Integrins alphaVbeta3, alphaVbeta5, alpha3beta1, alpha5beta1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q03600", "map_id": "Q03600", "name": "ina-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002081", "map_id": "WBGene00002081", "name": "ina-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10549009", "map_id": "none", "name": "Endostatin:Integrins alphaVbeta3, alphaVbeta5, alpha3beta1, alpha5beta1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10517427", "map_id": "none", "name": "Interaction of integrin alpha9beta1 with Tenascin-C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10517423", "map_id": "none", "name": "Integrin alpha9beta1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10517415", "map_id": "none", "name": "Tenascin-C hexamer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10517425", "map_id": "none", "name": "Integrin alpha9beta1:Tenascin-C hexamer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10517398", "map_id": "none", "name": "Integrins alpha4beta1, alpha8beta1, alphaVbeta1, alphaVbeta3, alphaVbeta6 bind Fibronectin matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10517392", "map_id": "none", "name": "Integrin alpha4beta1, alpha8beta1, alphaVbeta1, alphaVbeta3, alphaVbeta6", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10517396", "map_id": "none", "name": "Integrin alpha4beta1, alpha8beta1, alphaVbeta6:Fibronectin matrix", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10544599", "map_id": "none", "name": "Collagen type XIII binds Integrin alpha1beta1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10543907", "map_id": "none", "name": "ITGA1:ITGB1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10544597", "map_id": "none", "name": "Collagen type XIII:Integrin alpha1beta1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10517290", "map_id": "none", "name": "Collagen type II binds integrin alpha10beta1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10517168", "map_id": "none", "name": "Integrin alpha10beta1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10517288", "map_id": "none", "name": "Integrin alpha10beta1:Collagen type II fibril:Mg2+", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10543915", "map_id": "none", "name": "Collagen types III, IV, V, VI, VIII, IX, XVI bind integrins alpha1beta1 and alpha2beta1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10543911", "map_id": "none", "name": "Collagen types III, IV, V, VI, VIII, IX, XVI", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10543909", "map_id": "none", "name": "Integrin alpha1beta1, alpha2beta1, alpha10beta1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10543913", "map_id": "none", "name": "Collagen types III, IV, V, VI, VIII, IX, XVI:Integrins alpha1beta 1, alpha2beta1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10517419", "map_id": "none", "name": "Interaction of integrin alpha8beta1 with Tenascin-C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10517386", "map_id": "none", "name": "Integrin alpha8beta1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10517417", "map_id": "none", "name": "Integrin alpha8beta1:Tenascin-C hexamer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10503155", "map_id": "none", "name": "PXLP-K314-GPT transaminates L-Ala to form PYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10503152", "map_id": "none", "name": "PXLP-K314-GPT dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "O01685", "map_id": "O01685", "name": "PXLP-K341-GPT2-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016333", "map_id": "WBGene00016333", "name": "PXLP-K341-GPT2-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10527117", "map_id": "none", "name": "PXLP-K341-GPT2 transaminates PYR to form L-Ala", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_379697", "map_id": "CHEBI:57972", "name": "L-Ala", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10527114", "map_id": "none", "name": "PXLP-K341-GPT2 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "reaction_10522765", "map_id": "none", "name": "Endonucleolytic RISC hydrolyzes target RNAs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_426523", "map_id": "none", "name": "RNA (exact match)", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_426511", "map_id": "none", "name": "Cleaved RNA with 5' Phosphate and 3' Hydroxyl", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10522752", "map_id": "none", "name": "Endonucleolytic RISC", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10571586", "map_id": "none", "name": "p-S216-CDC25C translocates to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10507368", "map_id": "none", "name": "Phosphorylation of Cdc25C at Ser216 by CHEK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10572187", "map_id": "none", "name": "All-trans retinoic acid binds RARA:RXRA at the promoter of the CEBPE gene", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_5334804", "map_id": "CHEBI:15367", "name": "atRA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10572179", "map_id": "none", "name": "CEBPE gene:RARA:RXRA", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10572185", "map_id": "none", "name": "CEBPE gene:RXRA:RARA:atRA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10520037", "map_id": "none", "name": "Formation of PPARG:RXRA heterodimer (ARF6 complex)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10519413", "map_id": "none", "name": "Homologues of PPARG", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10520035", "map_id": "none", "name": "PPARG:RXRA Heterodimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10535206", "map_id": "none", "name": "Phospho R-SMAD(SMAD2/3):CO-SMAD(SMAD4):FOXO3 binds FoxO3a-binding elements", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_1535904", "map_id": "none", "name": "FoxO3a-binding Element", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10535204", "map_id": "none", "name": "SMAD2,3:SMAD4:FOXO3:FoxO3a-binding Element", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10525296", "map_id": "none", "name": "Phosphorylation of MEF2 proteins by p38", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10525266", "map_id": "Q9U325", "name": "mef-2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00003182", "map_id": "WBGene00003182", "name": "phospho-mef-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10525280", "map_id": "none", "name": "phospho-p38 alpha/beta/gamma MAPK", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10525293", "map_id": "none", "name": "phospho p38:phospho MEF2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9U325", "map_id": "Q9U325", "name": "phospho-mef-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10525370", "map_id": "none", "name": "Interaction of MyoD:E protein with MEF2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10525291", "map_id": "none", "name": "phospho-MEF2 proteins", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10525366", "map_id": "none", "name": "Myod:phospho-E heterodimers", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "P22980", "map_id": "P22980", "name": "hlh-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001948", "map_id": "WBGene00001948", "name": "hlh-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EEG9", "map_id": "G5EEG9", "name": "phospho-hlh-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001949", "map_id": "WBGene00001949", "name": "phospho-hlh-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10525368", "map_id": "none", "name": "MyoD:phospho-E:phospho MEF2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10518843", "map_id": "none", "name": "CDO binds BOC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10518839", "map_id": "Q53U87", "name": "sax-7", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10518837", "map_id": "Q53U87", "name": "sax-7", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10518841", "map_id": "none", "name": "CDO:BOC", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10525341", "map_id": "none", "name": "Nuclear translocation of p38 MAPK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10525339", "map_id": "none", "name": "pp38 alpha/beta/gamma:ABL1:JLP:CDO complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "P34609", "map_id": "P34609", "name": "unc-16", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006755", "map_id": "WBGene00006755", "name": "unc-16", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P03949", "map_id": "P03949", "name": "abl-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10525337", "map_id": "none", "name": "ABL1:JLP:CDO complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10544128", "map_id": "none", "name": "Latent TGF-beta-3 binds integrins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10517390", "map_id": "none", "name": "Integrin alphaVbeta1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10544124", "map_id": "none", "name": "TGF-beta-3:LAP3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10544126", "map_id": "none", "name": "TGF-beta-3:LAP3:LAP3-binding integrins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10544040", "map_id": "none", "name": "Latent TGF-beta-1 binds integrins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10544036", "map_id": "none", "name": "LAP1 binding-integrins", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10544034", "map_id": "none", "name": "TGF-beta-1:LAP1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10544038", "map_id": "none", "name": "TGF-beta-1:LAP1:LAP1-binding integrins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10544857", "map_id": "none", "name": "Fibulin-1 and -2 bind fibronectin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10535682", "map_id": "Q17494", "name": "FBLN2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "WBGene00007170", "map_id": "WBGene00007170", "name": "FBLN2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10544855", "map_id": "none", "name": "FBLN1, FBLN2:Fibronectin matrix", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "Q17494", "map_id": "Q17494", "name": "FBLN2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10530641", "map_id": "none", "name": "PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_977329", "map_id": "CHEBI:30933", "name": "3POPA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_936706", "map_id": "CHEBI:15811", "name": "O-P-Ser", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10530638", "map_id": "none", "name": "PXLP-K200-PSAT1 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P91856", "map_id": "P91856", "name": "PXLP-K200-PSAT1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009177", "map_id": "WBGene00009177", "name": "PXLP-K200-PSAT1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10530630", "map_id": "none", "name": "PSPH:Mg2+ dimer dephosphorylates O-P-Ser", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10530627", "map_id": "none", "name": "PSPH:Mg2+ dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "A0A061ACK7", "map_id": "A0A061ACK7", "name": "PSPH", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013379", "map_id": "WBGene00013379", "name": "PSPH", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10568102", "map_id": "none", "name": "SERINC3,5,(1,2,4) transport L-Ser from cytosol to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_8932979", "map_id": "CHEBI:33384", "name": "L-Ser", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10568099", "map_id": "none", "name": "SERINC3,5,(1,2,4)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q95XV3", "map_id": "Q95XV3", "name": "SERINC5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021956", "map_id": "WBGene00021956", "name": "SERINC5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O45719", "map_id": "O45719", "name": "SERINC5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10571288", "map_id": "none", "name": "PXLP-K56-SRR dimer deaminates D-Ser", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10571285", "map_id": "none", "name": "PXLP-K56-SRR dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q93968", "map_id": "Q93968", "name": "serr-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011353", "map_id": "WBGene00011353", "name": "serr-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10571291", "map_id": "none", "name": "PXLP-K56-SRR dimer isomerises L-Ser to D-Ser", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10530651", "map_id": "none", "name": "PHGHD tetramer dehydrogenates 3PG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10530648", "map_id": "none", "name": "PHGHD tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "O17626", "map_id": "O17626", "name": "PHGDH", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007836", "map_id": "WBGene00007836", "name": "PHGDH", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10571806", "map_id": "none", "name": "PXLP-K56-SRR dimer deaminates L-Ser", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10542969", "map_id": "none", "name": "abacavir monophosphate + H2O => carbovir monophosphate + cyclopropylamine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_2161194", "map_id": "none", "name": "abacavir monophosphate", "type": "reactant", "sub_type": "other", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_2161176", "map_id": "none", "name": "carbovir monophosphate", "type": "product", "sub_type": "other", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_2161175", "map_id": "CHEBI:34660", "name": "cyclopropylamine", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10542964", "map_id": "none", "name": "ADAL:Zn", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q8IG39", "map_id": "Q8IG39", "name": "adal-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016632", "map_id": "WBGene00016632", "name": "adal-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10543017", "map_id": "none", "name": "carbovir + IMP => carbovir monophosphate + inosine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_2161514", "map_id": "none", "name": "carbovir", "type": "reactant", "sub_type": "other", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10506658", "map_id": "none", "name": "NT5C2 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q95X21", "map_id": "Q95X21", "name": "NT5C2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022201", "map_id": "WBGene00022201", "name": "NT5C2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10543020", "map_id": "none", "name": "abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_2161185", "map_id": "none", "name": "abacavir", "type": "product", "sub_type": "other", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_2162081", "map_id": "CHEBI:64192", "name": "abacavir 5'-carboxylic acid", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10504238", "map_id": "none", "name": "ADH1A:2Zn2+ dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10552511", "map_id": "none", "name": "AGO1,2:small RNA complexes interact with chromatin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10552507", "map_id": "none", "name": "AGO1,2:miRNA", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "O16720", "map_id": "O16720", "name": "alg-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000106", "map_id": "WBGene00000106", "name": "alg-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O61931", "map_id": "O61931", "name": "ergo-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019971", "map_id": "WBGene00019971", "name": "ergo-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O62275", "map_id": "O62275", "name": "wago-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010263", "map_id": "WBGene00010263", "name": "wago-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34681", "map_id": "P34681", "name": "tag-76", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006449", "map_id": "WBGene00006449", "name": "tag-76", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q09249", "map_id": "Q09249", "name": "EIF2C1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007624", "map_id": "WBGene00007624", "name": "EIF2C1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q21691", "map_id": "Q21691", "name": "nrde-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019862", "map_id": "WBGene00019862", "name": "nrde-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q21770", "map_id": "Q21770", "name": "wago-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011061", "map_id": "WBGene00011061", "name": "wago-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86NJ8", "map_id": "Q86NJ8", "name": "ppw-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004093", "map_id": "WBGene00004093", "name": "ppw-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9N585", "map_id": "Q9N585", "name": "ppw-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004094", "map_id": "WBGene00004094", "name": "ppw-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A0T7CIX3", "map_id": "A0A0T7CIX3", "name": "sago-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019666", "map_id": "WBGene00019666", "name": "sago-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9TXN7", "map_id": "Q9TXN7", "name": "wago-10", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020707", "map_id": "WBGene00020707", "name": "wago-10", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A0U1RML5", "map_id": "A0A0U1RML5", "name": "sago-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018921", "map_id": "WBGene00018921", "name": "sago-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XVI3", "map_id": "Q9XVI3", "name": "alg-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011945", "map_id": "WBGene00011945", "name": "alg-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "D9N120", "map_id": "D9N120", "name": "wago-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022877", "map_id": "WBGene00022877", "name": "wago-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5ED77", "map_id": "G5ED77", "name": "alg-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011910", "map_id": "WBGene00011910", "name": "alg-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EEH0", "map_id": "G5EEH0", "name": "rde-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004323", "map_id": "WBGene00004323", "name": "rde-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "H2KZD5", "map_id": "H2KZD5", "name": "csr-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017641", "map_id": "WBGene00017641", "name": "csr-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10552509", "map_id": "none", "name": "AGO1,2:miRNA:chromatin:RNA pol II", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10571531", "map_id": "none", "name": "AGO2 cleaves passenger strand of duplex siRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10542709", "map_id": "none", "name": "AGO2:duplex siRNA", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10571528", "map_id": "none", "name": "AGO2:cleaved duplex siRNA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10522748", "map_id": "none", "name": "Dicer cleaves double-stranded RNA to yield double-stranded siRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_426463", "map_id": "none", "name": "Double-stranded RNA", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10515589", "map_id": "none", "name": "TARBP2,PRKRA RLC", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10522745", "map_id": "none", "name": "TARBP2,PRKRA RLC:duplex siRNA", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10542733", "map_id": "none", "name": "Removal of siRNA passenger strand", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10542723", "map_id": "none", "name": "TARBP2,PRKRA:DICER1:Pre-RISC (siRNA)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10542731", "map_id": "none", "name": "TARBP2,PRKRA:DICER1:RISC (siRNA)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10542735", "map_id": "none", "name": "Duplex siRNA is loaded into Argonaute", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10536517", "map_id": "none", "name": "PXLP-K212-CTH cleaves L-Cystathionine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1614518", "map_id": "CHEBI:17482", "name": "L-Cystathionine", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10536491", "map_id": "none", "name": "PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10536488", "map_id": "none", "name": "PXLP-CBS tetramers", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "G5EFH8", "map_id": "G5EFH8", "name": "cbs-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013866", "map_id": "WBGene00013866", "name": "cbs-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10537680", "map_id": "none", "name": "I(1,3,4,5)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_2023891", "map_id": "CHEBI:16783", "name": "I(1,3,4,5)P4", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_2023901", "map_id": "CHEBI:16322", "name": "I(1,3,4,5,6)P5", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10537657", "map_id": "O62519", "name": "ipmk-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00014081", "map_id": "WBGene00014081", "name": "ipmk-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10537761", "map_id": "none", "name": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/2 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_2023940", "map_id": "CHEBI:30164", "name": "5-PP-IP5", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_2023941", "map_id": "CHEBI:62985", "name": "5-PPP-IP5", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10537560", "map_id": "none", "name": "IP6K1/2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "O02167", "map_id": "O02167", "name": "IP6K1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021260", "map_id": "WBGene00021260", "name": "IP6K1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q93644", "map_id": "Q93644", "name": "IP6K1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9BKX8", "map_id": "Q9BKX8", "name": "IP6K1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10537683", "map_id": "none", "name": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/2 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_2023929", "map_id": "CHEBI:17401", "name": "IP6", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10537767", "map_id": "none", "name": "I(1,3,4,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_2023892", "map_id": "CHEBI:16155", "name": "I(1,3,4,6)P4", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10537640", "map_id": "none", "name": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_2023922", "map_id": "CHEBI:62928", "name": "5-PP-IP4", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10537770", "map_id": "none", "name": "5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_2023948", "map_id": "CHEBI:62931", "name": "1,5-(PP)2-IP3", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10537563", "map_id": "none", "name": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_2023932", "map_id": "CHEBI:62919", "name": "1-PP-IP5", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_2023931", "map_id": "CHEBI:62923", "name": "1,5-(PP)2-IP4", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10537660", "map_id": "none", "name": "I(1,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_2023935", "map_id": "CHEBI:16067", "name": "I(1,4,5,6)P4", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10537773", "map_id": "none", "name": "I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by IPMK in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_2023907", "map_id": "CHEBI:16595", "name": "I(1,4,5)P3", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10537614", "map_id": "none", "name": "I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK (IP5-2K) in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10537611", "map_id": "Q9XXI1", "name": "ippk-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00012466", "map_id": "WBGene00012466", "name": "ippk-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10509797", "map_id": "none", "name": "PAO:FAD oxidises NASPM to PTCN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_141349", "map_id": "CHEBI:17927", "name": "NASPM", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_141327", "map_id": "CHEBI:30322", "name": "3AAPNAL", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_141350", "map_id": "CHEBI:17148", "name": "PTCN", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_10509794", "map_id": "none", "name": "PAOX:FAD", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "true" }, { "id": "reaction_10518005", "map_id": "none", "name": "Spermine => N-acetylated spermine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_353575", "map_id": "CHEBI:17312", "name": "NASPN", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10518002", "map_id": "O17731", "name": "SAT1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00008408", "map_id": "WBGene00008408", "name": "SAT1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10518007", "map_id": "none", "name": "Spermidine => N-acetylated spermidine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_353555", "map_id": "CHEBI:17927", "name": "NASPM", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10509799", "map_id": "none", "name": "PAOX:FAD oxidises NASPN to SPM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_141323", "map_id": "CHEBI:17312", "name": "NASPN", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "reaction_10518160", "map_id": "none", "name": "26S proteosome degrades ODC holoenzyme complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10517946", "map_id": "none", "name": "ODC:OAZ complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9NHZ6", "map_id": "Q9NHZ6", "name": "oaz-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022748", "map_id": "WBGene00022748", "name": "oaz-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P41931", "map_id": "P41931", "name": "odc-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003844", "map_id": "WBGene00003844", "name": "odc-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O01579", "map_id": "O01579", "name": "AZIN1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018764", "map_id": "WBGene00018764", "name": "AZIN1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10517940", "map_id": "Q9NHZ6", "name": "oaz-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10517948", "map_id": "none", "name": "Antizyme OAZ binds to Ornithine decarboxylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10503318", "map_id": "none", "name": "Homologues of PXLP-K69-ODC1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10517965", "map_id": "none", "name": "Antizyme inhibitor binds to OAZ and stablizes ODC complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10517959", "map_id": "none", "name": "Homologues of AZIN1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10517963", "map_id": "none", "name": "AZIN1 bound OAZ:ODC complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10517953", "map_id": "none", "name": "Arginine<=>Agmatine+CO2", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10517950", "map_id": "P41931", "name": "odc-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10518023", "map_id": "none", "name": "S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_353113", "map_id": "CHEBI:15625", "name": "dc-AdoMet", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10518020", "map_id": "O02655", "name": "smd-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00004875", "map_id": "WBGene00004875", "name": "smd-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10503321", "map_id": "none", "name": "ornithine => putrescine + CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29610", "map_id": "CHEBI:17148", "name": "Putrescine", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10518015", "map_id": "none", "name": "Putrescine + dc-Adenosyl methionine => Spermidine + 5'-methylthioadenosine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10518012", "map_id": "B4E3X6", "name": "spds-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00012909", "map_id": "WBGene00012909", "name": "spds-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10537235", "map_id": "none", "name": "PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_172574", "compartment_display": "late endosome membrane" }, { "id": "species_1806195", "map_id": "CHEBI:16749", "name": "PI", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_172574", "compartment_display": "late endosome membrane", "complex": "false" }, { "id": "species_1806198", "map_id": "CHEBI:17283", "name": "PI3P", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_172574", "compartment_display": "late endosome membrane", "complex": "false" }, { "id": "reaction_10537123", "map_id": "none", "name": "PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_172574", "compartment_display": "late endosome membrane" }, { "id": "species_10537120", "map_id": "none", "name": "MTM1,MTMR2,MTMR4,MTMR7", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10537247", "map_id": "none", "name": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_172574", "compartment_display": "late endosome membrane" }, { "id": "species_1806289", "map_id": "CHEBI:16851", "name": "PI(3,5)P2", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_172574", "compartment_display": "late endosome membrane", "complex": "false" }, { "id": "species_1806212", "map_id": "CHEBI:16500", "name": "PI5P", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_172574", "compartment_display": "late endosome membrane", "complex": "false" }, { "id": "reaction_10573048", "map_id": "none", "name": "Formation of the CTF18-RFC(7s) complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10502620", "map_id": "P34429", "name": "RFC5", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10502635", "map_id": "O44175", "name": "rfc-2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10511819", "map_id": "none", "name": "CTF18 complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q22664", "map_id": "Q22664", "name": "ctf-8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011915", "map_id": "WBGene00011915", "name": "ctf-8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O44992", "map_id": "O44992", "name": "dscc-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019595", "map_id": "WBGene00019595", "name": "dscc-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q21350", "map_id": "Q21350", "name": "ctf-18", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010676", "map_id": "WBGene00010676", "name": "ctf-18", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10502630", "map_id": "Q18547", "name": "rfc-3", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10502625", "map_id": "P53016", "name": "rfc-4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10511821", "map_id": "none", "name": "CTF18-RFC(7s) complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10573050", "map_id": "none", "name": "Formation of the CTF18 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10511807", "map_id": "Q21350", "name": "ctf-18", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10511817", "map_id": "O44992", "name": "dscc-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10511812", "map_id": "Q22664", "name": "ctf-8", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10555879", "map_id": "none", "name": "SIRT6 deacetylates RBBP8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10555871", "map_id": "none", "name": "Ac-K432,K526,K604-RBBP8 homotetramer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q18606", "map_id": "Q18606", "name": "com-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008082", "map_id": "WBGene00008082", "name": "com-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10555659", "map_id": "none", "name": "RBBP8 homotetramer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10555876", "map_id": "Q95Q89", "name": "sir-2.4", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00004803", "map_id": "WBGene00004803", "name": "sir-2.4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10506532", "map_id": "none", "name": "Abortive initiation after formation of the first phosphodiester bond", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_109877", "map_id": "none", "name": "template DNA with first transcript dinucleotide, opened to +8 position", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10509383", "map_id": "none", "name": "Formation of FACT complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10509276", "map_id": "P41848", "name": "hmg-4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10509281", "map_id": "Q9N5R9", "name": "spt-16", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10509385", "map_id": "none", "name": "Formation of P-TEFb complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10509215", "map_id": "none", "name": "CCNT1,CCNT2,CCNK", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10509194", "map_id": "Q9TVL3", "name": "cdk-9", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10509217", "map_id": "none", "name": "P-TEFb complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10507434", "map_id": "none", "name": "Fall Back to Closed Pre-initiation Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10509387", "map_id": "none", "name": "Formation of DSIF complex ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10509232", "map_id": "Q9TZ93", "name": "spt-4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10509389", "map_id": "none", "name": "Formation of Elongin BC complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10509293", "map_id": "G5ECR7", "name": "elb-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10509288", "map_id": "Q9BKS1", "name": "elc-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10509295", "map_id": "none", "name": "Elongin B:C complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10509391", "map_id": "none", "name": "Formation of Elongin complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10509300", "map_id": "Q09413", "name": "tceb-3", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10509395", "map_id": "none", "name": "Abortive termination of early transcription elongation by DSIF:NELF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10509360", "map_id": "none", "name": "DSIF:NELF:early elongation complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10509397", "map_id": "none", "name": "2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10509369", "map_id": "none", "name": "Paused processive elongation complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10509401", "map_id": "none", "name": "TFIIS-mediated recovery of elongation from arrest", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10509371", "map_id": "none", "name": "Resumption of elongation after recovery from pausing", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10509403", "map_id": "none", "name": "7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10507581", "map_id": "none", "name": "Abortive Initiation After Second Transition", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10507579", "map_id": "none", "name": "pol II transcription complex containing 4-9 nucleotide long transcript", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_75897", "map_id": "none", "name": "template DNA:4-9 nucleotide transcript hybrid", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10507422", "map_id": "none", "name": "Abortive Initiation Before Second Transition", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10507420", "map_id": "none", "name": "Pol II Promoter Escape Complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_110068", "map_id": "none", "name": "DNA containing Pol II promoter with transcript with 2 or 3 nucleotides", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10509375", "map_id": "none", "name": "Abortive termination of elongation after arrest", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10509373", "map_id": "none", "name": "Aborted elongation complex after arrest", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10517522", "map_id": "none", "name": "cholesterol + phosphatidylcholine (lecithin) => cholesterol ester + 2-lysophosphatidylcholine (lysolecithin)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_194236", "map_id": "CHEBI:17504", "name": "1-acyl LPC", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10517519", "map_id": "Q21515", "name": "LCAT", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10516629", "map_id": "none", "name": "Ca2+ influx through voltage gated Ca2+ channels", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10516626", "map_id": "none", "name": "Voltage Gated Ca2+ Channel", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "A0A3B1E663", "map_id": "A0A3B1E663", "name": "unc-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006742", "map_id": "WBGene00006742", "name": "unc-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EBI8", "map_id": "G5EBI8", "name": "stg-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017400", "map_id": "WBGene00017400", "name": "stg-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EDT2", "map_id": "G5EDT2", "name": "stg-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007670", "map_id": "WBGene00007670", "name": "stg-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O01661", "map_id": "O01661", "name": "ccb-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000368", "map_id": "WBGene00000368", "name": "ccb-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A078BQJ0", "map_id": "A0A078BQJ0", "name": "ccb-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021125", "map_id": "WBGene00021125", "name": "ccb-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10565831", "map_id": "none", "name": "FITM1, FITM2 bind TAGs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10565825", "map_id": "Q5CZ37", "name": "fitm-2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "WBGene00044094", "map_id": "WBGene00044094", "name": "fitm-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10565829", "map_id": "none", "name": "(FITM1,FITM2):TAGs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q5CZ37", "map_id": "Q5CZ37", "name": "fitm-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10565903", "map_id": "none", "name": "HSD17B13 binds lipid droplets", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_8866926", "map_id": "none", "name": "lipid droplet", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_13977", "compartment_display": "lipid droplet", "complex": "true" }, { "id": "species_8876704", "map_id": "CHEBI:17002", "name": "CHEST", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "CHEBI:16247", "map_id": "CHEBI:16247", "name": "CHEBI:16247", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10565901", "map_id": "none", "name": "HSD17B13:lipid droplet", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_13977", "compartment_display": "lipid droplet", "complex": "true" }, { "id": "reaction_10542689", "map_id": "none", "name": "Secretion of collagens", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_10542497", "map_id": "none", "name": "Collagens and tropocollagens:Serpin H1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "species_10542687", "map_id": "none", "name": "Collagens and tropocollagens", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10540972", "map_id": "none", "name": "Homologues of SERPINH1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "reaction_10536930", "map_id": "none", "name": "Prolyl 4-hydroxylase converts collagen prolines to 4-hydroxyprolines", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_10536805", "map_id": "none", "name": "P4HB:Collagen propeptides", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "species_1650779", "map_id": "CHEBI:16810", "name": "2OG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10536918", "map_id": "none", "name": "4-Hyp collagen propeptides:P4HB", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "species_10536927", "map_id": "none", "name": "Prolyl 4-hydroxylases", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "CHEBI:29073", "map_id": "CHEBI:29073", "name": "CHEBI:29073", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "B1V8J4", "map_id": "B1V8J4", "name": "phy-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012815", "map_id": "WBGene00012815", "name": "phy-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10539491", "map_id": "none", "name": "Glucosylation of collagen propeptide hydroxylysines", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10539158", "map_id": "none", "name": "PLOD3:Fe2+ dimer:Galactosyl-hydroxylysyl collagen propeptides", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q20679", "map_id": "Q20679", "name": "let-268", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002497", "map_id": "WBGene00002497", "name": "let-268", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10539488", "map_id": "none", "name": "PLOD3:Fe2+ dimer:Glucosyl-galactosyl-hydroxylysyl collagen propeptides", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "species_10538479", "map_id": "none", "name": "PLOD3:Fe2+ dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10568836", "map_id": "none", "name": "PLOD3 binds Lysyl hydroxylated collagen propeptides", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_10538808", "map_id": "none", "name": "Lysyl hydroxylated collagen propeptides", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10539156", "map_id": "none", "name": "PLOD3:Fe2+ dimer:Lysyl hydroxylated collagen propeptides", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10568838", "map_id": "none", "name": "PLOD3:Fe2+ dimer:Galactosyl-hydroxylysyl collagen propeptides dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_10539149", "map_id": "none", "name": "Galactosyl-hydroxylysyl collagen propeptides", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "reaction_10568840", "map_id": "none", "name": "PLOD3:Fe2+ dimer:Glucosyl-galactosyl-hydroxylysyl collagen propeptides dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_10539486", "map_id": "none", "name": "Glucosyl-galactosyl-hydroxylysyl collagen propeptides", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "reaction_10568842", "map_id": "none", "name": "COLGALT1,COLGALT2 bind Lysyl hydroxylated collagen propeptides", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_10538822", "map_id": "none", "name": "COLGALT1,COLGALT2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "Q18989", "map_id": "Q18989", "name": "COLGALT2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008426", "map_id": "WBGene00008426", "name": "COLGALT2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10538824", "map_id": "none", "name": "COLGALT1,COLGALT2:Lysyl hydroxylated collagen propeptides", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "reaction_10540780", "map_id": "none", "name": "Removal of fibrillar collagen N-propeptides", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10540153", "map_id": "none", "name": "Fibrillar procollagens", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10540761", "map_id": "none", "name": "Fibrillar procollagens -N", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10540777", "map_id": "none", "name": "Procollagen N-proteinases", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "Q20176", "map_id": "Q20176", "name": "nas-39", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003555", "map_id": "WBGene00003555", "name": "nas-39", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10568844", "map_id": "none", "name": "COLGALT1,COLGALT2:Galactosyl-hydroxylysyl collagen propeptides dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_10539151", "map_id": "none", "name": "COLGALT1,COLGALT2:Galactosyl-hydroxylysyl collagen propeptides", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "reaction_10568846", "map_id": "none", "name": "Lysyl hydroxylated collagen propeptides dissociate from Lysyl hydroxylases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_10538810", "map_id": "none", "name": "Lysyl hydroxylases:Lysyl hydroxylated collagen propeptides", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "species_10538481", "map_id": "none", "name": "Lysyl hydroxylases", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10568848", "map_id": "none", "name": "P4HB:4-Hyp collagen propeptides dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_10536685", "map_id": "Q17770", "name": "pdi-2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10536916", "map_id": "none", "name": "4-Hyp collagen propeptides", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "reaction_10540785", "map_id": "none", "name": "Removal of fibrillar collagen C-propeptides", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10540775", "map_id": "Q20176", "name": "nas-39", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10539154", "map_id": "none", "name": "Galactosylation of collagen propeptide hydroxylysines by procollagen galactosyltransferases 1, 2.", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "reaction_10540787", "map_id": "none", "name": "P4HB binds Collagen chains", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_10536803", "map_id": "none", "name": "Collagen propeptides", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "reaction_10542934", "map_id": "none", "name": "Secretion of transmembrane collagens", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "reaction_10539161", "map_id": "none", "name": "Galactosylation of collagen propeptide hydroxylysines by PLOD3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "reaction_10538460", "map_id": "none", "name": "Collagen prolyl 3-hydroxylase converts 4-Hyp collagen to 3,4-Hyp collagen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_10538344", "map_id": "none", "name": "Prolyl 3-hydroxylases:Fe2+:4-Hyp collagen propeptides", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "species_10538457", "map_id": "none", "name": "Prolyl 3-hydroxylases:Fe2+:3,4-Hyp collagen propeptides", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "reaction_10538813", "map_id": "none", "name": "Procollagen lysyl hydroxylases convert collagen lysines to 5-hydroxylysines", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10538483", "map_id": "none", "name": "Lysyl hydroxylases:Lysyl hydroxylase procollagen substrates", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10510320", "map_id": "none", "name": "PhosphoChREBP (Thr 666) is exported to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10510226", "map_id": "P41846", "name": "phospho-mml-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00003378", "map_id": "WBGene00003378", "name": "mml-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10510224", "map_id": "P41846", "name": "phospho-mml-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10510228", "map_id": "none", "name": "Nuclear transport of pChREBP (Thr 666) protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10572971", "map_id": "none", "name": "ABCC1 transports BIL from cytosol to extracellular region (blood)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_189386", "map_id": "CHEBI:16990", "name": "BIL", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_9661418", "map_id": "CHEBI:16990", "name": "BIL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10516833", "map_id": "none", "name": "glutamate uptake by astrocytes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10516830", "map_id": "none", "name": "Astrocytic EAATs", "type": "catalyst", "sub_type": "", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10503235", "map_id": "none", "name": "glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10503232", "map_id": "none", "name": "GLUL decamer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q95YD1", "map_id": "Q95YD1", "name": "gln-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001602", "map_id": "WBGene00001602", "name": "gln-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9U307", "map_id": "Q9U307", "name": "gln-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001604", "map_id": "WBGene00001604", "name": "gln-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O02225", "map_id": "O02225", "name": "gln-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001607", "map_id": "WBGene00001607", "name": "gln-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XVU2", "map_id": "Q9XVU2", "name": "gln-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001606", "map_id": "WBGene00001606", "name": "gln-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34497", "map_id": "P34497", "name": "gln-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001603", "map_id": "WBGene00001603", "name": "gln-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10544113", "map_id": "none", "name": "NUDT18 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_2395883", "map_id": "CHEBI:63728", "name": "8-oxo-dGDP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_2395817", "map_id": "CHEBI:63223", "name": "8-oxo-dGMP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10544108", "map_id": "O45830", "name": "ndx-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00003578", "map_id": "WBGene00003578", "name": "ndx-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10544116", "map_id": "none", "name": "NUDT18 hydrolyses 8-OH-dADP to 8-OH-dAMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_2395963", "map_id": "CHEBI:70963", "name": "8-hydroxy-dADP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_2395964", "map_id": "CHEBI:70964", "name": "8-hydroxy-dAMP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10543958", "map_id": "none", "name": "Mitochondrial NUDT9 hydrolyses ADP-ribose to R5P and AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_2393945", "map_id": "CHEBI:16960", "name": "ADP-Rib", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_2393950", "map_id": "CHEBI:17797", "name": "R5P", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_159448", "map_id": "CHEBI:16027", "name": "adenosine 5'-monophosphate", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10543955", "map_id": "none", "name": "NUDT9", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q09297", "map_id": "Q09297", "name": "ndx-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003583", "map_id": "WBGene00003583", "name": "ndx-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10543948", "map_id": "none", "name": "Cytosolic NUDT5 hydrolyses ADP-ribose to R5P and AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1131972", "map_id": "CHEBI:16960", "name": "ADP-D-ribose", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10543945", "map_id": "none", "name": "NUDT5 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "O61902", "map_id": "O61902", "name": "ndx-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003579", "map_id": "WBGene00003579", "name": "ndx-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10544111", "map_id": "none", "name": "NUDT18 hydrolyses 8-oxo-GDP to 8-oxo-GMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_2395880", "map_id": "CHEBI:65134", "name": "8-oxo-GDP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_2395877", "map_id": "CHEBI:65135", "name": "8-oxo-GMP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10529189", "map_id": "none", "name": "Cargo Recognition And Sorting", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10529158", "map_id": "none", "name": "ESCRT-I", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "true" }, { "id": "O76258", "map_id": "O76258", "name": "tsg-101", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00015658", "map_id": "WBGene00015658", "name": "tsg-101", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8WTK0", "map_id": "Q8WTK0", "name": "spe-48", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021771", "map_id": "WBGene00021771", "name": "spe-48", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q17687", "map_id": "Q17687", "name": "mvb-12", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00015508", "map_id": "WBGene00015508", "name": "mvb-12", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O44158", "map_id": "O44158", "name": "vps-37", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016990", "map_id": "WBGene00016990", "name": "vps-37", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q4R133", "map_id": "Q4R133", "name": "VPS37B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00044542", "map_id": "WBGene00044542", "name": "VPS37B", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9NA26", "map_id": "Q9NA26", "name": "vps-28", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013598", "map_id": "WBGene00013598", "name": "vps-28", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10529187", "map_id": "none", "name": "ESCRT-0/Cargo Complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "true" }, { "id": "species_10529160", "map_id": "none", "name": "ESCRT-I/Cargo Complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "true" }, { "id": "species_10529185", "map_id": "none", "name": "ESCRT-0", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10529181", "map_id": "none", "name": "Cargo Sequestration", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10529177", "map_id": "none", "name": "ESCRT-II", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9U354", "map_id": "Q9U354", "name": "vps-25", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012193", "map_id": "WBGene00012193", "name": "vps-25", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q19519", "map_id": "Q19519", "name": "vps-36", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008919", "map_id": "WBGene00008919", "name": "vps-36", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q18258", "map_id": "Q18258", "name": "vps-22", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016167", "map_id": "WBGene00016167", "name": "vps-22", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10529179", "map_id": "none", "name": "ESCRT-II/Cargo Complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "true" }, { "id": "reaction_10529183", "map_id": "none", "name": "MVB Vesicle Formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10529112", "map_id": "none", "name": "ESCRT-III/Cargo Complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "true" }, { "id": "reaction_10518835", "map_id": "none", "name": "Noradrenalin synaptic vesicle docking and priming", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10518823", "map_id": "none", "name": "Noradrenalin loaded synaptic vesicle", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20592", "compartment_display": "clathrin-coated endocytic vesicle", "complex": "true" }, { "id": "species_10518825", "map_id": "none", "name": "Docked Noradrenalin loaded synaptic vesicle", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10518409", "map_id": "none", "name": "Loading of dopamine into synaptic veiscles", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_374932", "compartment_display": "clathrin-sculpted monoamine transport vesicle lumen" }, { "id": "reaction_10518830", "map_id": "none", "name": "Release of noradrenaline at the synapse", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "reaction_10551442", "map_id": "none", "name": "LIN7, CASK and APBA1 bind", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10519883", "map_id": "A5PEX5", "name": "lin-7", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10519873", "map_id": "O17583", "name": "lin-10", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00002999", "map_id": "WBGene00002999", "name": "lin-10", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10519889", "map_id": "none", "name": "LIN7:CASK:APBA1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "O17583", "map_id": "O17583", "name": "lin-10", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10519891", "map_id": "none", "name": "Dopamine synaptic vesicle docking and priming", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10519854", "map_id": "none", "name": "Dopamine loaded synaptic vesicle", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_374940", "compartment_display": "clathrin-sculpted monoamine transport vesicle membrane", "complex": "true" }, { "id": "species_10519867", "map_id": "none", "name": "Docked dopamine loaded synaptic vesicle", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10519942", "map_id": "none", "name": "Release of docked dopamine loaded synaptic vesicle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "reaction_10563003", "map_id": "none", "name": "NAAA hydrolyses NAEs to FAs and ethanolamine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_6803725", "map_id": "none", "name": "NAEs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "true" }, { "id": "CHEBI:71466", "map_id": "CHEBI:71466", "name": "CHEBI:71466", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_5693752", "map_id": "CHEBI:2700", "name": "AEA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_13977", "compartment_display": "lipid droplet", "complex": "false" }, { "id": "CHEBI:85299", "map_id": "CHEBI:85299", "name": "CHEBI:85299", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:85263", "map_id": "CHEBI:85263", "name": "CHEBI:85263", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:71464", "map_id": "CHEBI:71464", "name": "CHEBI:71464", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:85262", "map_id": "CHEBI:85262", "name": "CHEBI:85262", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_6803745", "map_id": "CHEBI:16000", "name": "ETA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_6803778", "map_id": "none", "name": "FAs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "true" }, { "id": "species_10563000", "map_id": "none", "name": "NAAA dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "true" }, { "id": "Q9GUI1", "map_id": "Q9GUI1", "name": "NAAA (126-349)", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021917", "map_id": "WBGene00021917", "name": "NAAA (126-349)", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10565443", "map_id": "none", "name": "MAN2B1 hydrolyses GlcNAc (Man)5 to GlcNAc (Man)3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_6799577", "map_id": "CHEBI:91279", "name": "alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_6799594", "map_id": "CHEBI:4208", "name": "Man", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_10565440", "map_id": "none", "name": "MAN2B1:Zn2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "true" }, { "id": "reaction_10565448", "map_id": "none", "name": "MANBA hydrolyses GlcNAc:Man", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_8853719", "map_id": "CHEBI:71553", "name": "GlcNAc:Man", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_10565445", "map_id": "Q93324", "name": "MANBA", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "reaction_10562091", "map_id": "none", "name": "MAN2B2 hydrolyses GlcNAc (Man)3 to GlcNAc:Man", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_10562088", "map_id": "none", "name": "MAN2B2:Zn2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "true" }, { "id": "reaction_10554447", "map_id": "none", "name": "POLK incorporates dNMP opposite to damaged DNA base", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10554438", "map_id": "none", "name": "POLK:REV1:POLZ:MonoUb:K164-PCNA:RPA:RFC:Tg-DNA Template,OGUA-DNA Template,BPDE-G-DNA Template", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "A0A0K3AUS7", "map_id": "A0A0K3AUS7", "name": "rev-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021344", "map_id": "WBGene00021344", "name": "rev-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10554444", "map_id": "none", "name": "POLK:REV1:POLZ:MonoUb:K164-PCNA:RPA:RFC:(Tg:A)-DNA Template,(OGUA:A)-DNA Template,(BPDE-G:C)-DNA Template", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10506096", "map_id": "none", "name": "beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_73588", "map_id": "CHEBI:18261", "name": "UPROP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_73590", "map_id": "CHEBI:16958", "name": "b-Ala", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10506093", "map_id": "none", "name": "UPB1:Zn2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q19437", "map_id": "Q19437", "name": "upb-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017440", "map_id": "WBGene00017440", "name": "upb-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10506128", "map_id": "none", "name": "thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_73541", "map_id": "CHEBI:27468", "name": "5,6-Dihydrothymine", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10506073", "map_id": "none", "name": "DPYD dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q18164", "map_id": "Q18164", "name": "dpyd-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016103", "map_id": "WBGene00016103", "name": "dpyd-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10506130", "map_id": "none", "name": "5,6-dihydrothymine + H2O => beta-ureidoisobutyrate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_73617", "map_id": "CHEBI:1670", "name": "UIBA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10506083", "map_id": "none", "name": "DPYS tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10506132", "map_id": "none", "name": "beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_73619", "map_id": "CHEBI:16320", "name": "3AIB", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10506086", "map_id": "none", "name": "5,6-dihydrouracil + H2O => beta-ureidopropionate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_73584", "map_id": "CHEBI:15901", "name": "5,6-Dihydrouracil", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10506681", "map_id": "none", "name": "(deoxy)uridine + orthophosphate <=> uracil + (deoxy)ribose 1-phosphate (UPP)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10506076", "map_id": "none", "name": "uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10508397", "map_id": "none", "name": "(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C3)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_500347", "map_id": "none", "name": "(d)CMP, TMP, (d)UMP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:15918", "map_id": "CHEBI:15918", "name": "CHEBI:15918", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_500742", "map_id": "CHEBI:17622", "name": "dUMP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_500346", "map_id": "none", "name": "(d)C, T, (d)U", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10508394", "map_id": "none", "name": "NT5C3 holoenzyme", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q09315", "map_id": "Q09315", "name": "NT5C3-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q95ZJ9", "map_id": "Q95ZJ9", "name": "NT5C3-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10506641", "map_id": "none", "name": "(deoxy)inosine + orthophosphate <=> hypoxanthine + (deoxy)ribose 1-phosphate (NP)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_500172", "map_id": "none", "name": "Ino, dI", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:28997", "map_id": "CHEBI:28997", "name": "CHEBI:28997", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10506638", "map_id": "none", "name": "NP trimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10544722", "map_id": "none", "name": "ITPA hydrolyses dITP to dIMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_2509835", "map_id": "CHEBI:28807", "name": "dITP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_109330", "map_id": "CHEBI:28806", "name": "dIMP", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10544713", "map_id": "none", "name": "ITPA dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9GYG4", "map_id": "Q9GYG4", "name": "hap-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001823", "map_id": "WBGene00001823", "name": "hap-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10506661", "map_id": "none", "name": "(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_500120", "map_id": "none", "name": "(d)GMP, (d)IMP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:16192", "map_id": "CHEBI:16192", "name": "CHEBI:16192", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_500118", "map_id": "none", "name": "Gu-Rib, dG, Ino, dI", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:17172", "map_id": "CHEBI:17172", "name": "CHEBI:17172", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10506663", "map_id": "none", "name": "(deoxy)guanosine + orthophosphate <=> guanine + (deoxy)ribose 1-phosphate (NP)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_500245", "map_id": "none", "name": "G, dG", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10506665", "map_id": "none", "name": "Xanthine + H2O + O2 => Urate + H2O2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_30064", "map_id": "CHEBI:17712", "name": "XAN", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10506648", "map_id": "none", "name": "XDH dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10506651", "map_id": "none", "name": "Hypoxanthine + H2O + O2 => Xanthine + H2O2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10544716", "map_id": "none", "name": "ITPA hydrolyses ITP to IMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_2509836", "map_id": "CHEBI:16039", "name": "ITP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10544719", "map_id": "none", "name": "ITPA hydrolyses XTP to XMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_2509848", "map_id": "CHEBI:10049", "name": "XTP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10566331", "map_id": "none", "name": "SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_8866574", "map_id": "CHEBI:61560", "name": "dNTP(4-)", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_8866608", "map_id": "CHEBI:18274", "name": "2'-deoxynucleoside", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_8866567", "map_id": "CHEBI:18036", "name": "PPPi", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10566328", "map_id": "none", "name": "SAMHD1:Zn2+ tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q09374", "map_id": "Q09374", "name": "SAMHD1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022673", "map_id": "WBGene00022673", "name": "SAMHD1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10565105", "map_id": "none", "name": "NTPDase4 hydrolyzes nucleoside triphosphates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "species_8851233", "map_id": "none", "name": "UTP,GTP,CTP,dTTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "species_8851224", "map_id": "none", "name": "UDP,GDP,CDP,dTDP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "CHEBI:18075", "map_id": "CHEBI:18075", "name": "CHEBI:18075", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10565099", "map_id": "none", "name": "NTPDase4:Ca2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "Q18411", "map_id": "Q18411", "name": "ntp-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016380", "map_id": "WBGene00016380", "name": "ntp-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q21815", "map_id": "Q21815", "name": "mig-23", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003254", "map_id": "WBGene00003254", "name": "mig-23", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10565122", "map_id": "none", "name": "NTPDase6 hydrolyzes nucleoside diphosphates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_8851462", "map_id": "none", "name": "CDP,GDP,IDP,UDP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "CHEBI:17808", "map_id": "CHEBI:17808", "name": "CHEBI:17808", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_8851461", "map_id": "none", "name": "CMP,GMP,IMP,UMP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10565119", "map_id": "none", "name": "NTPDase6:Ca2+,Mg2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "Q9XU84", "map_id": "Q9XU84", "name": "uda-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010697", "map_id": "WBGene00010697", "name": "uda-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10565129", "map_id": "none", "name": "NTPDase7 hydrolyzes nucleoside triphosphates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_528865", "compartment_display": "endocytic vesicle lumen" }, { "id": "species_8851517", "map_id": "CHEBI:15377", "name": "H2O", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_528865", "compartment_display": "endocytic vesicle lumen", "complex": "false" }, { "id": "species_8851509", "map_id": "none", "name": "CTP,GTP,UTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_528865", "compartment_display": "endocytic vesicle lumen", "complex": "true" }, { "id": "species_8851513", "map_id": "CHEBI:43474", "name": "Pi", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_528865", "compartment_display": "endocytic vesicle lumen", "complex": "false" }, { "id": "species_8851518", "map_id": "none", "name": "CDP,GDP,UDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_528865", "compartment_display": "endocytic vesicle lumen", "complex": "true" }, { "id": "species_10565126", "map_id": "none", "name": "NTPDase7:Ca2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_24337", "compartment_display": "endocytic vesicle membrane", "complex": "true" }, { "id": "reaction_10565115", "map_id": "none", "name": "NTPDase5 hydrolyzes nucleoside diphosphates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_8936165", "map_id": "none", "name": "ADP,GDP,CDP,UDP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_8851369", "map_id": "none", "name": "AMP,GMP,CMP,UMP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10565112", "map_id": "none", "name": "NPTDase5:Ca2+,Mg2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10565102", "map_id": "none", "name": "NTPDase4 hydrolyzes nucleoside diphosphates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "species_8851227", "map_id": "none", "name": "UMP,GMP,CMP,dTMP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "reaction_10506608", "map_id": "none", "name": "Adenine + PRPP => AMP + PPi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10506605", "map_id": "none", "name": "APRT dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10542967", "map_id": "none", "name": "N6-methyl-AMP + H2O => IMP + methylamine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_2161190", "map_id": "CHEBI:40196", "name": "N6-methyl-AMP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_2161177", "map_id": "CHEBI:16830", "name": "methylamine", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10506631", "map_id": "none", "name": "(2'-deoxy)adenosine + H2O => (2'-deoxy)inosine + NH4+ (ADA)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_500173", "map_id": "none", "name": "Ade-Rib, dA", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10506628", "map_id": "H2KYI5", "name": "adah-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00015551", "map_id": "WBGene00015551", "name": "adah-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10527223", "map_id": "none", "name": "GMP + NADPH + H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10527220", "map_id": "none", "name": "GMPR tetramers", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "O16294", "map_id": "O16294", "name": "GMPR", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017984", "map_id": "WBGene00017984", "name": "GMPR", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10508120", "map_id": "none", "name": "AMP + H2O => IMP + NH4+ (AMPD)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10508117", "map_id": "none", "name": "AMPD tetramers", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10506618", "map_id": "none", "name": "guanine or hypoxanthine + PRPP => GMP or IMP + PPi (HPRT1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_500259", "map_id": "none", "name": "Gua, Hyp", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_500260", "map_id": "none", "name": "GMP, IMP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10506615", "map_id": "none", "name": "HGPRT tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9NF11", "map_id": "Q9NF11", "name": "hprt-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013690", "map_id": "WBGene00013690", "name": "hprt-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10508442", "map_id": "none", "name": "(2'-deoxy)adenosine + ATP => (d)AMP + ADP (ADK)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_500088", "map_id": "none", "name": "(d)AMP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_109386", "map_id": "CHEBI:17713", "name": "2'-deoxyadenosine 5'-monophosphate", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10508439", "map_id": "none", "name": "ADK", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q93934", "map_id": "Q93934", "name": "adk-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011128", "map_id": "WBGene00011128", "name": "adk-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10508640", "map_id": "none", "name": "AK5,7,8,9 phosphorylates (d)NMPs to (d)NDPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_6788778", "map_id": "none", "name": "(d)NMPs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_6788782", "map_id": "none", "name": "(d)NDPs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:28846", "map_id": "CHEBI:28846", "name": "CHEBI:28846", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:16174", "map_id": "CHEBI:16174", "name": "CHEBI:16174", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10508635", "map_id": "none", "name": "AK5 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q20140", "map_id": "Q20140", "name": "AK5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009531", "map_id": "WBGene00009531", "name": "AK5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10508896", "map_id": "none", "name": "glutaredoxin (oxidized) + glutathione (reduced) => glutaredoxin (reduced) + glutathione (oxidized)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10508874", "map_id": "Q9N456", "name": "glrx-10", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00021331", "map_id": "WBGene00021331", "name": "glrx-10", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10508871", "map_id": "Q9N456", "name": "glrx-10", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10506017", "map_id": "none", "name": "(d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP (CMPK1)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_500009", "map_id": "none", "name": "(d)CMP, UMP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_500006", "map_id": "none", "name": "(d)CDP, UDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10506014", "map_id": "none", "name": "CMPK1, AK1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q20230", "map_id": "Q20230", "name": "CMPK1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009575", "map_id": "WBGene00009575", "name": "CMPK1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10508642", "map_id": "none", "name": "(d)ADP + ADP <=> (d)AMP + ATP (AK1)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_500087", "map_id": "none", "name": "(d)ADP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10506620", "map_id": "none", "name": "Adenylate Kinase", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10508899", "map_id": "none", "name": "RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_8866401", "map_id": "CHEBI:57930", "name": "NDP(3-)", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_8866399", "map_id": "CHEBI:73316", "name": "dNDP(3-)", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10508890", "map_id": "none", "name": "RNR (M1M2)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q03604", "map_id": "Q03604", "name": "rnr-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004391", "map_id": "WBGene00004391", "name": "rnr-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P42170", "map_id": "P42170", "name": "rnr-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004392", "map_id": "WBGene00004392", "name": "rnr-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_110644", "map_id": "CHEBI:16284", "name": "dATP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10563109", "map_id": "none", "name": "NME1:NME3 heterohexamer, NME2P1 phosphorylate NDPs to NTPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_6806885", "map_id": "CHEBI:16862", "name": "NDP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_6806881", "map_id": "CHEBI:17326", "name": "NTP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10563106", "map_id": "none", "name": "NME1:NME3 heterohexamer, NME2P1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q7KX00", "map_id": "Q7KX00", "name": "NME1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021692", "map_id": "WBGene00021692", "name": "NME1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10526887", "map_id": "none", "name": "(d)NDP + ATP <=> (d)NTP + ADP (NME1,2,3)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_482627", "map_id": "none", "name": "(d)NDP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:28850", "map_id": "CHEBI:28850", "name": "CHEBI:28850", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:28862", "map_id": "CHEBI:28862", "name": "CHEBI:28862", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_482625", "map_id": "none", "name": "(d)NTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_500739", "map_id": "CHEBI:17625", "name": "dUTP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10526884", "map_id": "none", "name": "NME1,2 hexamers", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10506152", "map_id": "none", "name": "dUMP or TMP + ATP <=> dUDP or TDP + ADP [DTYMK]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_499997", "map_id": "none", "name": "dUMP, TMP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_499999", "map_id": "none", "name": "dUDP, TDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10506149", "map_id": "none", "name": "DTYMK dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q22018", "map_id": "Q22018", "name": "dtmk-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011272", "map_id": "WBGene00011272", "name": "dtmk-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10508650", "map_id": "none", "name": "ADP + ADP <=> AMP + ATP [AK2]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10508647", "map_id": "P34346", "name": "let-754", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "false" }, { "id": "WBGene00002879", "map_id": "WBGene00002879", "name": "let-754", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10508908", "map_id": "none", "name": "RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10508905", "map_id": "none", "name": "RNR (M1M2B)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10527086", "map_id": "none", "name": "(d)NDP + ATP <=> (d)NTP + ADP (NME4)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_482803", "map_id": "none", "name": "(d)NDP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "species_482807", "map_id": "none", "name": "(d)NTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "species_10527083", "map_id": "none", "name": "NME4 hexamer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "reaction_10506180", "map_id": "none", "name": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10506177", "map_id": "none", "name": "CTPS tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "G5EC98", "map_id": "G5EC98", "name": "ctps-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012316", "map_id": "WBGene00012316", "name": "ctps-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10506116", "map_id": "none", "name": "dUMP + N5,N10-methylene tetrahydrofolate => TMP + dihydrofolate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_109382", "map_id": "CHEBI:17622", "name": "dUMP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10506113", "map_id": "none", "name": "TS dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9N588", "map_id": "Q9N588", "name": "tyms-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022455", "map_id": "WBGene00022455", "name": "tyms-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10527109", "map_id": "none", "name": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10527106", "map_id": "none", "name": "CTPS2 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10566276", "map_id": "none", "name": "RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10558343", "map_id": "none", "name": "AK6 phosphorylates (d)NMPs to (d)NDPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_6788813", "map_id": "none", "name": "(d)NMPs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_6788807", "map_id": "none", "name": "(d)NDPs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10558340", "map_id": "Q09527", "name": "AK6", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00008458", "map_id": "WBGene00008458", "name": "AK6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10506190", "map_id": "none", "name": "dUTP + H2O => dUMP + pyrophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10506187", "map_id": "none", "name": "DUT trimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "G5EET2", "map_id": "G5EET2", "name": "dut-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010609", "map_id": "WBGene00010609", "name": "dut-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10508631", "map_id": "none", "name": "(d)GDP + ADP <=> (d)GMP + ATP (GUK1)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_500077", "map_id": "none", "name": "(d)GDP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_500071", "map_id": "none", "name": "(d)GMP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10506329", "map_id": "P91425", "name": "guk-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00020190", "map_id": "WBGene00020190", "name": "guk-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10508893", "map_id": "none", "name": "RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10508638", "map_id": "none", "name": "(d)ADP or (d)CDP + ADP <=> (d)AMP or (d)CMP + ATP", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10542971", "map_id": "none", "name": "abacavir [extracellular] => abacavir [cytosol]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_2161525", "map_id": "none", "name": "abacavir", "type": "reactant", "sub_type": "other", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10510416", "map_id": "none", "name": "Enzyme-bound ATP is released", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10510410", "map_id": "none", "name": "ATPase:ATP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "reaction_10510418", "map_id": "none", "name": "ADP and Pi bind to ATPase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10510408", "map_id": "none", "name": "ATPase:ADP:Pi", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "reaction_10510413", "map_id": "none", "name": "ATPase synthesizes ATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "reaction_10546133", "map_id": "none", "name": "COX15 transforms heme O to heme A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_2995328", "map_id": "CHEBI:24480", "name": "heme O", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_2995348", "map_id": "CHEBI:24479", "name": "heme A", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10546130", "map_id": "Q22251", "name": "cox-15", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "WBGene00011526", "map_id": "WBGene00011526", "name": "cox-15", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10529229", "map_id": "none", "name": "ABCG2 tetramer transports heme from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_917877", "map_id": "CHEBI:17627", "name": "heme", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10529226", "map_id": "none", "name": "ABCG2 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "D7SFK1", "map_id": "D7SFK1", "name": "abcx-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006522", "map_id": "WBGene00006522", "name": "abcx-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10546125", "map_id": "none", "name": "COX10 transforms heme to heme O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_189444", "map_id": "CHEBI:17627", "name": "heme", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_2162257", "map_id": "CHEBI:17407", "name": "FPP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10546122", "map_id": "K8ES01", "name": "cox-10", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "WBGene00012895", "map_id": "WBGene00012895", "name": "cox-10", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10512862", "map_id": "none", "name": "FECH binds Fe2+ to PRIN9 to form heme", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_189487", "map_id": "CHEBI:15430", "name": "PRIN9", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10512859", "map_id": "none", "name": "2x(FECH:2Fe-2S cluster)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "G5EBW5", "map_id": "G5EBW5", "name": "fecl-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010645", "map_id": "WBGene00010645", "name": "fecl-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_391232", "map_id": "CHEBI:27889", "name": "Pb2+", "type": "inhibitor", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10572969", "map_id": "none", "name": "SLCO1B1 transports BIL from extracellular region (blood) to cytosol (hepatocyte)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10573000", "map_id": "none", "name": "SLCO1B3 transports BIL from extracellular region (blood) to cytosol (hepatocyte)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10572997", "map_id": "none", "name": "Homologues of SLCO1B3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10572987", "map_id": "none", "name": "SLCO2B1-3 transports BIL from extracellular region (blood) to cytosol (hepatocyte)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10572984", "map_id": "none", "name": "Homologues of SLCO2B1-3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10573004", "map_id": "none", "name": "BIL dissociates from GSTA1, FABP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10573002", "map_id": "none", "name": "BIL:GSTA1, FABP1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10551347", "map_id": "none", "name": "Homologues of FABP1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10573006", "map_id": "none", "name": "BIL binds GSTA1, FABP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10572974", "map_id": "none", "name": "ABCG2 tetramer transports BMG,BDG from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5679042", "map_id": "none", "name": "BMG,BDG", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:18392", "map_id": "CHEBI:18392", "name": "CHEBI:18392", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:16427", "map_id": "CHEBI:16427", "name": "CHEBI:16427", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_5679034", "map_id": "none", "name": "BMG,BDG", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10535157", "map_id": "none", "name": "Uncoupled eNOS favours the formation of superoxide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10551508", "map_id": "none", "name": "CYGB dioxygenates NO", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_432031", "map_id": "CHEBI:17632", "name": "NO3-", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10567554", "map_id": "none", "name": "CARNMT1 methylates CARN to Anserine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_6786250", "map_id": "CHEBI:15727", "name": "CARN", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_8876775", "map_id": "CHEBI:18323", "name": "Anserine", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10567551", "map_id": "O62483", "name": "CARNMT1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00013015", "map_id": "WBGene00013015", "name": "CARNMT1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10503510", "map_id": "none", "name": "urocanate + H2O => 4-imidazolone-5-propionate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_30721", "map_id": "CHEBI:30817", "name": "UCA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_34979", "map_id": "CHEBI:27384", "name": "4I-5PROA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10503507", "map_id": "none", "name": "UROC1:NAD+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9NAE2", "map_id": "Q9NAE2", "name": "UROC1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013103", "map_id": "WBGene00013103", "name": "UROC1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10503500", "map_id": "none", "name": "histidine => urocanate + NH4+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29612", "map_id": "CHEBI:32513", "name": "L-His", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10503497", "map_id": "Q20502", "name": "haly-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00009813", "map_id": "WBGene00009813", "name": "haly-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10503518", "map_id": "none", "name": "4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_30158", "map_id": "CHEBI:18327", "name": "NF-Glu", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10503515", "map_id": "Q22419", "name": "AMDHD1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00020436", "map_id": "WBGene00020436", "name": "AMDHD1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10571277", "map_id": "none", "name": "HRSP12 deaminates 2AA to 2OBUTA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9014643", "map_id": "CHEBI:58020", "name": "2AA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10571274", "map_id": "Q10121", "name": "Q10121", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00016011", "map_id": "WBGene00016011", "name": "Q10121", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10503714", "map_id": "none", "name": "alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_70951", "map_id": "CHEBI:15753", "name": "aKADA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_70955", "map_id": "CHEBI:15524", "name": "GL-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10503541", "map_id": "none", "name": "alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_508531", "map_id": "CHEBI:17082", "name": "2AMA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10503538", "map_id": "none", "name": "ALDH7A1 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "P46562", "map_id": "P46562", "name": "alh-9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000115", "map_id": "WBGene00000115", "name": "alh-9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10503528", "map_id": "none", "name": "lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_30176", "map_id": "CHEBI:16927", "name": "SACN", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10503525", "map_id": "none", "name": "AASS tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "U4PFH6", "map_id": "U4PFH6", "name": "aass-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019819", "map_id": "WBGene00019819", "name": "aass-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10503531", "map_id": "none", "name": "saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "reaction_10518299", "map_id": "none", "name": "2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_113577", "map_id": "CHEBI:15753", "name": "aKADA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10518296", "map_id": "O62347", "name": "slc-25a21", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "WBGene00011226", "map_id": "WBGene00011226", "name": "slc-25a21", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10503724", "map_id": "none", "name": "glutaryl-CoA + FAD => crotonyl-CoA + FADH2 + CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_71045", "map_id": "CHEBI:15473", "name": "crotonyl-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10503721", "map_id": "none", "name": "GCDH tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q20772", "map_id": "Q20772", "name": "GCDH", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010052", "map_id": "WBGene00010052", "name": "GCDH", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10558014", "map_id": "none", "name": "PIPOX oxidises PPCA to P6C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_5693325", "map_id": "CHEBI:30913", "name": "PPCA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_6783877", "map_id": "CHEBI:58769", "name": "P6C", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_10558011", "map_id": "Q18006", "name": "PIPOX", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "reaction_10570157", "map_id": "none", "name": "SEPHS2 phosphorylates H2Se to form SELP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_8959518", "map_id": "CHEBI:16144", "name": "SELP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10570154", "map_id": "O62461", "name": "seld-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00012867", "map_id": "WBGene00012867", "name": "seld-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10551250", "map_id": "none", "name": "MeSeO2H is reduced to MeSeOH by TXNRD1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5357694", "map_id": "CHEBI:77012", "name": "MeSeO2H", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_5357663", "map_id": "CHEBI:77062", "name": "MeSeOH", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10551247", "map_id": "none", "name": "MeSeOH is reduced to MeSeH by TXNRD1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5357669", "map_id": "CHEBI:64685", "name": "MeSeH", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10518289", "map_id": "none", "name": "SLC25A12,13 exchange cytosolic L-Glu for mitochondrial matrix L-Asp", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_113553", "map_id": "CHEBI:29991", "name": "L-Asp", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10518286", "map_id": "none", "name": "SLC25A12,13", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "Q21153", "map_id": "Q21153", "name": "SLC25A12", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019326", "map_id": "WBGene00019326", "name": "SLC25A12", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10503201", "map_id": "none", "name": "GOT2 dimer deaminates L-Asp", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10503198", "map_id": "none", "name": "GOT2 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q17994", "map_id": "Q17994", "name": "got-2.2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00015778", "map_id": "WBGene00015778", "name": "got-2.2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10557141", "map_id": "none", "name": "NAALADases hydrolyse NAAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_5693762", "map_id": "CHEBI:76931", "name": "NAAG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_5693772", "map_id": "CHEBI:16953", "name": "NAASP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10557138", "map_id": "none", "name": "NAALADases", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "P91406", "map_id": "P91406", "name": "gcp-2.1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020082", "map_id": "WBGene00020082", "name": "gcp-2.1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q93332", "map_id": "Q93332", "name": "gcp-2.2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007954", "map_id": "WBGene00007954", "name": "gcp-2.2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10503190", "map_id": "none", "name": "PXLP-K259-GOT1 dimer deaminates L-Asp", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10503175", "map_id": "none", "name": "PXLP-K259-GOT1 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q22067", "map_id": "Q22067", "name": "got-1.2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020146", "map_id": "WBGene00020146", "name": "got-1.2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10559320", "map_id": "none", "name": "ASPG hydrolyses L-Asn to L-Asp", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29642", "map_id": "CHEBI:58048", "name": "L-Asn", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10559317", "map_id": "Q9U3P0", "name": "ASPG", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00007756", "map_id": "WBGene00007756", "name": "ASPG", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10503178", "map_id": "none", "name": "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10503296", "map_id": "none", "name": "glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_31339", "map_id": "CHEBI:17232", "name": "L-Glu5S", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10503281", "map_id": "none", "name": "OAT hexamer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q18040", "map_id": "Q18040", "name": "oatr-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00015814", "map_id": "WBGene00015814", "name": "oatr-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10503265", "map_id": "none", "name": "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT2]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "reaction_10503203", "map_id": "none", "name": "glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ [GLUD1]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_517495", "map_id": "none", "name": "NAD(P)+", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "species_517496", "map_id": "none", "name": "NAD(P)H", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "species_10503185", "map_id": "none", "name": "GLUD hexamer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q23621", "map_id": "Q23621", "name": "gdh-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10503188", "map_id": "none", "name": "alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ [GLUD1]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "reaction_10558039", "map_id": "none", "name": "PYCRL decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_35305", "map_id": "CHEBI:17388", "name": "1PYR-5COOH", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_113538", "map_id": "CHEBI:60039", "name": "L-Pro", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10558036", "map_id": "none", "name": "PYCRL decamer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q21544", "map_id": "Q21544", "name": "pycr-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010924", "map_id": "WBGene00010924", "name": "pycr-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q20848", "map_id": "Q20848", "name": "PYCR2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018904", "map_id": "WBGene00018904", "name": "PYCR2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10527197", "map_id": "none", "name": "glutamate + ATP + NADPH + H+ => L-glutamate gamma-semialdehyde + NADP+ + ADP + orthophosphate [P5CS]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10527194", "map_id": "none", "name": "P5CS dimers", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "P54889", "map_id": "P54889", "name": "alh-13", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011938", "map_id": "WBGene00011938", "name": "alh-13", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10558028", "map_id": "none", "name": "PYCR2 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_113590", "map_id": "CHEBI:17388", "name": "1PYR-5COOH", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_379717", "map_id": "CHEBI:60039", "name": "L-Pro", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10558025", "map_id": "none", "name": "PYCR2 decamer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "reaction_10503294", "map_id": "none", "name": "PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10503291", "map_id": "none", "name": "PYCR1 decamer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "reaction_10528415", "map_id": "none", "name": "glutamine + pyruvate => 2-oxoglutaramate + alanine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_893598", "map_id": "CHEBI:30882", "name": "2OGA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10516466", "map_id": "none", "name": "Dopa is decarboxylated to dopamine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10516446", "map_id": "none", "name": "Noradrenaline is converted to adrenaline", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10516443", "map_id": "none", "name": "Homologues of PNMT", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q20308", "map_id": "Q20308", "name": "anmt-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018340", "map_id": "WBGene00018340", "name": "anmt-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q22279", "map_id": "Q22279", "name": "anmt-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011573", "map_id": "WBGene00011573", "name": "anmt-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34254", "map_id": "P34254", "name": "anmt-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10516399", "map_id": "none", "name": "Tyrosine is hydroxylated to dopa", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10516396", "map_id": "none", "name": "TH:Fe2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P90986", "map_id": "P90986", "name": "cat-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000296", "map_id": "WBGene00000296", "name": "cat-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10516464", "map_id": "none", "name": "Monoiodinated tyrosine can be deiodinated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_351627", "map_id": "CHEBI:16474", "name": "NADPH", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_351639", "map_id": "CHEBI:27847", "name": "MIT", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_352030", "map_id": "CHEBI:58315", "name": "L-Tyr", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_351628", "map_id": "CHEBI:18009", "name": "NADP+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10516461", "map_id": "none", "name": "DEHAL1:FMN", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "P34273", "map_id": "P34273", "name": "sup-18", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00015334", "map_id": "WBGene00015334", "name": "sup-18", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10516468", "map_id": "none", "name": "DIT and MIT combine to form triiodothyronine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_352329", "map_id": "CHEBI:15768", "name": "DIT", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_352331", "map_id": "CHEBI:28774", "name": "T3", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_352036", "map_id": "CHEBI:57972", "name": "L-Ala", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10516386", "map_id": "none", "name": "Homologues of TPO", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10557028", "map_id": "none", "name": "DUOX1,2 reduce O2 to H2O2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10557025", "map_id": "none", "name": "DUOX1,2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "O01795", "map_id": "O01795", "name": "duox-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018771", "map_id": "WBGene00018771", "name": "duox-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O61213", "map_id": "O61213", "name": "bli-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000253", "map_id": "WBGene00000253", "name": "bli-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10516389", "map_id": "none", "name": "Tyrosine is monoiodinated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_351630", "map_id": "CHEBI:17606", "name": "I2", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_622410", "map_id": "CHEBI:43451", "name": "HI", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10516454", "map_id": "none", "name": "Iodide is taken up by thyroid epithelial cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10516451", "map_id": "O17394", "name": "SLC5A5", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10516470", "map_id": "none", "name": "Diiodinated tyrosine can be deiodinated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "reaction_10516472", "map_id": "none", "name": "Tyrosine is diiodinated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "reaction_10517997", "map_id": "none", "name": "Iodide is organified", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "reaction_10516413", "map_id": "none", "name": "Two DITs combine to form thyroxine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "reaction_10567841", "map_id": "none", "name": "TYRP1 oxidises DHICA to IQCA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5668575", "compartment_display": "melanosome membrane" }, { "id": "species_5662670", "map_id": "CHEBI:2003", "name": "DHICA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5668572", "compartment_display": "melanosome lumen", "complex": "false" }, { "id": "species_5668566", "map_id": "CHEBI:15379", "name": "O2", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5668572", "compartment_display": "melanosome lumen", "complex": "false" }, { "id": "species_8878586", "map_id": "CHEBI:81394", "name": "IQCA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5668572", "compartment_display": "melanosome lumen", "complex": "false" }, { "id": "species_5668574", "map_id": "CHEBI:15377", "name": "H2O", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5668572", "compartment_display": "melanosome lumen", "complex": "false" }, { "id": "species_10567838", "map_id": "none", "name": "Homologues of TYRP1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5668575", "compartment_display": "melanosome membrane", "complex": "true" }, { "id": "O01497", "map_id": "O01497", "name": "tyr-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016419", "map_id": "WBGene00016419", "name": "tyr-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O76708", "map_id": "O76708", "name": "tyr-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021553", "map_id": "WBGene00021553", "name": "tyr-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34269", "map_id": "P34269", "name": "tyr-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00015332", "map_id": "WBGene00015332", "name": "tyr-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q19673", "map_id": "Q19673", "name": "tyr-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009001", "map_id": "WBGene00009001", "name": "tyr-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q95XC6", "map_id": "Q95XC6", "name": "tyr-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022231", "map_id": "WBGene00022231", "name": "tyr-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XUS8", "map_id": "Q9XUS8", "name": "tyr-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010661", "map_id": "WBGene00010661", "name": "tyr-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10554582", "map_id": "none", "name": "Tyrosinase oxidises tyrosine to dopaquinone", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5668575", "compartment_display": "melanosome membrane" }, { "id": "species_5668573", "map_id": "CHEBI:29191", "name": "hydroxyl", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5668572", "compartment_display": "melanosome lumen", "complex": "false" }, { "id": "species_5668567", "map_id": "CHEBI:58315", "name": "L-Tyr", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5668572", "compartment_display": "melanosome lumen", "complex": "false" }, { "id": "species_5668577", "map_id": "CHEBI:15378", "name": "H+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5668572", "compartment_display": "melanosome lumen", "complex": "false" }, { "id": "species_5662695", "map_id": "CHEBI:16852", "name": "L-Dopaquinone", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5668572", "compartment_display": "melanosome lumen", "complex": "false" }, { "id": "species_10554579", "map_id": "none", "name": "TYR:2xCu2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5668575", "compartment_display": "melanosome membrane", "complex": "true" }, { "id": "reaction_10554584", "map_id": "none", "name": "Dopa is oxidized to dopaquinone by TYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5668572", "compartment_display": "melanosome lumen" }, { "id": "species_5668568", "map_id": "CHEBI:15765", "name": "L-Dopa", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5668572", "compartment_display": "melanosome lumen", "complex": "false" }, { "id": "reaction_10554586", "map_id": "none", "name": "DHI and DHICA polymerise forming eumelanin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5668572", "compartment_display": "melanosome lumen" }, { "id": "species_5662708", "map_id": "none", "name": "DHI, DHICA", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5668572", "compartment_display": "melanosome lumen", "complex": "true" }, { "id": "CHEBI:27404", "map_id": "CHEBI:27404", "name": "CHEBI:27404", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_5662678", "map_id": "none", "name": "Eumelanin", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5668572", "compartment_display": "melanosome lumen", "complex": "true" }, { "id": "reaction_10554575", "map_id": "none", "name": "Dopachrome is transformed to DHICA by DCT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5668572", "compartment_display": "melanosome lumen" }, { "id": "species_5662665", "map_id": "CHEBI:49108", "name": "Dopachrome", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5668572", "compartment_display": "melanosome lumen", "complex": "false" }, { "id": "species_10554572", "map_id": "none", "name": "DCT:2xZn2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5668575", "compartment_display": "melanosome membrane", "complex": "true" }, { "id": "reaction_10559330", "map_id": "none", "name": "DMGDH:FAD oxidatively demethylates DMGLY to SARC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_6797923", "map_id": "CHEBI:17724", "name": "DMGLY", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_6797917", "map_id": "CHEBI:15611", "name": "SARC", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_6797920", "map_id": "CHEBI:16842", "name": "CH2O", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10559327", "map_id": "none", "name": "DMGDH:FAD", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "A0A486WWC6", "map_id": "A0A486WWC6", "name": "DMGDH", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021355", "map_id": "WBGene00021355", "name": "DMGDH", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10559333", "map_id": "none", "name": "ALDH7A1 oxidises BETALD to BET", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_6798194", "map_id": "CHEBI:15710", "name": "BETALD", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_6798202", "map_id": "CHEBI:17750", "name": "BET", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10503536", "map_id": "P46562", "name": "alh-9", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10559341", "map_id": "none", "name": "CHDH oxidises Cho to BETALD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10559338", "map_id": "Q18429", "name": "CHDH", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "WBGene00007917", "map_id": "WBGene00007917", "name": "CHDH", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10569987", "map_id": "none", "name": "PRODH2 oxidises HPRO to 1PYR-5COOH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_113597", "map_id": "CHEBI:16238", "name": "FAD", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "species_6784215", "map_id": "CHEBI:18240", "name": "HPRO", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_164934", "map_id": "CHEBI:17877", "name": "FADH2", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "species_10558041", "map_id": "O45228", "name": "prdh-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "WBGene00007197", "map_id": "WBGene00007197", "name": "prdh-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10503304", "map_id": "none", "name": "PRODH oxidises L-Pro to 1PYR-5COOH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10503301", "map_id": "O45228", "name": "prdh-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "reaction_10520736", "map_id": "none", "name": "Conversion of glyoxylate to oxalate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_389678", "map_id": "CHEBI:16891", "name": "glyoxylate", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_389819", "map_id": "CHEBI:16995", "name": "OX", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_10520730", "map_id": "none", "name": "HAO1 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "true" }, { "id": "reaction_10559137", "map_id": "none", "name": "LIAS:2(4Fe-4S) transforms octanoyl-K107-GCSH to lipoyl-K107-GCSH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_6793610", "map_id": "CHEBI:26833", "name": "S", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10559127", "map_id": "Q20634", "name": "gcsh-2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "WBGene00009918", "map_id": "WBGene00009918", "name": "gcsh-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_379705", "map_id": "CHEBI:57844", "name": "L-Met", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10557165", "map_id": "Q20634", "name": "gcsh-2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_6793613", "map_id": "CHEBI:17319", "name": "5dAde", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10559134", "map_id": "none", "name": "LIAS:2(4Fe-4S)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "CHEBI:49883", "map_id": "CHEBI:49883", "name": "CHEBI:49883", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q21452", "map_id": "Q21452", "name": "LIAS", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010809", "map_id": "WBGene00010809", "name": "LIAS", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10558048", "map_id": "none", "name": "PRODH2:FAD dimer dehydrogenates HPRO to 1-pyrroline-3-hydroxy-5-carboxylate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_6784241", "map_id": "CHEBI:27391", "name": "1-pyrroline-3-hydroxy-5-carboxylate", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10558045", "map_id": "none", "name": "PRODH2 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "O45228", "map_id": "O45228", "name": "prdh-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10520721", "map_id": "none", "name": "glycine + O2 => glyoxylate + H2O2 + NH4+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_193446", "map_id": "CHEBI:57305", "name": "Gly", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_389843", "map_id": "CHEBI:28938", "name": "NH4+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_10520718", "map_id": "none", "name": "DAO dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "true" }, { "id": "reaction_10559104", "map_id": "none", "name": "LIPT1 transfers lipoyl group from lipoyl-GCSH to DHs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10559088", "map_id": "none", "name": "DHs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q23629", "map_id": "Q23629", "name": "ogdh-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00014098", "map_id": "WBGene00014098", "name": "ogdh-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10557167", "map_id": "Q20634", "name": "gcsh-2", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10559096", "map_id": "none", "name": "lipoylated DHs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "species_10559101", "map_id": "O45303", "name": "LIPT1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "WBGene00001590", "map_id": "WBGene00001590", "name": "LIPT1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10558051", "map_id": "none", "name": "PXLP-K279-GOT2 dimer transaminates 4-OH-L-glutamate to 4-hydroxy-2-oxoglutarate (HOG)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_6784236", "map_id": "CHEBI:32812", "name": "4-OH-L-Glu", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_6784229", "map_id": "CHEBI:17742", "name": "HOG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10520662", "map_id": "none", "name": "glyoxylate + alanine => glycine + pyruvate [peroxisome]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_389664", "map_id": "CHEBI:57972", "name": "L-Ala", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_389680", "map_id": "CHEBI:15361", "name": "PYR", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_10520659", "map_id": "none", "name": "AGXT dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "true" }, { "id": "reaction_10563702", "map_id": "none", "name": "DDO oxidizes D-Asp to OA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_6810061", "map_id": "CHEBI:17364", "name": "D-Asp", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_6810070", "map_id": "CHEBI:30744", "name": "OA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_10563699", "map_id": "none", "name": "DDO:FAD", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "true" }, { "id": "reaction_10528441", "map_id": "none", "name": "Mitochondrial AGXT2 tetramer transaminates glyoxylate and alanine to glycine and pyruvate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10528438", "map_id": "none", "name": "AGXT2 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "O02158", "map_id": "O02158", "name": "PXLP-AGXT2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020382", "map_id": "WBGene00020382", "name": "PXLP-AGXT2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10557190", "map_id": "none", "name": "AMT transfers NH2CH2 from GCSH:SAMDLL to THF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10557169", "map_id": "none", "name": "GCSH:SAMDLL", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "CHEBI:14949", "map_id": "CHEBI:14949", "name": "CHEBI:14949", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q20634", "map_id": "Q20634", "name": "gcsh-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10557182", "map_id": "none", "name": "GCSH:DHLL", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "CHEBI:50746", "map_id": "CHEBI:50746", "name": "CHEBI:50746", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_5693984", "map_id": "CHEBI:12071", "name": "5,10-methylene-THF", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10557187", "map_id": "Q22968", "name": "gcst-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "WBGene00017765", "map_id": "WBGene00017765", "name": "gcst-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10557195", "map_id": "none", "name": "DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10557192", "map_id": "none", "name": "DLD dimer:2xFAD", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "reaction_10557180", "map_id": "none", "name": "PXLP-K754-GLDC dimer decarboxylates Gly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10557177", "map_id": "none", "name": "PXLP-K754-GLDC dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q21962", "map_id": "Q21962", "name": "gldc-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020022", "map_id": "WBGene00020022", "name": "gldc-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10520733", "map_id": "none", "name": "HAO1 tetramer oxidizes glycolate to glyoxylate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_389822", "map_id": "CHEBI:29805", "name": "glycolate", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "reaction_10503876", "map_id": "none", "name": "SHMT1 tetramer cleaves HTMLYS to yield TEABL and Gly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_31503", "map_id": "CHEBI:15786", "name": "HTMLYS", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_31311", "map_id": "CHEBI:18020", "name": "TEABL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10503865", "map_id": "none", "name": "TMLHE dimer dioxygenates TMLYS and 2OG to form HTMLYS and SUCCA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_35139", "map_id": "CHEBI:17311", "name": "TMLYS", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_113546", "map_id": "CHEBI:15786", "name": "HTMLYS", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10503862", "map_id": "none", "name": "TMLHE:AscH-:Fe2+ dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q21526", "map_id": "Q21526", "name": "gbh-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001523", "map_id": "WBGene00001523", "name": "gbh-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10503886", "map_id": "none", "name": "ALDH9A1 tetramer dehydrogenates TEABL to form TEABT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_31369", "map_id": "CHEBI:16244", "name": "TEABT", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10503883", "map_id": "none", "name": "ALDH9A1 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q20352", "map_id": "Q20352", "name": "alh-11", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000117", "map_id": "WBGene00000117", "name": "alh-11", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10534694", "map_id": "none", "name": "Carbonic anhydrase dehydrates bicarbonate (mitochondria)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10534691", "map_id": "none", "name": "CA5A,B:Zinc", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "reaction_10534663", "map_id": "none", "name": "Carbonic anhydrase dehydrates bicarbonate (cytosol)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10534660", "map_id": "none", "name": "CA1,2,3,7,13:Zinc", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10534696", "map_id": "none", "name": "Carbonic anhydrase hydrates carbon dioxide (mitochondria)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "reaction_10534665", "map_id": "none", "name": "Carbonic anhydrase hydrates carbon dioxide (cytosol)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10537601", "map_id": "none", "name": "PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_2023943", "map_id": "none", "name": "PP-IP4", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_1629736", "map_id": "CHEBI:62926", "name": "1-PP-IP4", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_1629755", "map_id": "CHEBI:62928", "name": "5-PP-IP4", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "CHEBI:62927", "map_id": "CHEBI:62927", "name": "CHEBI:62927", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_994141", "map_id": "CHEBI:16322", "name": "I(1,3,4,5,6)P5", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10537589", "map_id": "none", "name": "NUDT4:Mg2+/Mn2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q95XC4", "map_id": "Q95XC4", "name": "NUDT3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022366", "map_id": "WBGene00022366", "name": "NUDT3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10537634", "map_id": "none", "name": "I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1629770", "map_id": "CHEBI:17401", "name": "IP6", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10537631", "map_id": "Q9XXI1", "name": "ippk-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10537666", "map_id": "none", "name": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/3 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1629740", "map_id": "CHEBI:62919", "name": "1-PP-IP5", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_1629732", "map_id": "CHEBI:62923", "name": "1,5-(PP)2-IP4", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10537575", "map_id": "none", "name": "IP6K1/3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10537764", "map_id": "none", "name": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1629765", "map_id": "CHEBI:30164", "name": "5-PP-IP5", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10541476", "map_id": "none", "name": "1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_2023974", "map_id": "none", "name": "1/3-PP-IP5", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:62922", "map_id": "CHEBI:62922", "name": "CHEBI:62922", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10537595", "map_id": "none", "name": "NUDT(1)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10537669", "map_id": "none", "name": "5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10541478", "map_id": "none", "name": "(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_2023968", "map_id": "none", "name": "(PP)2-IP4", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:62924", "map_id": "CHEBI:62924", "name": "CHEBI:62924", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10537578", "map_id": "none", "name": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1629759", "map_id": "CHEBI:62985", "name": "5-PPP-IP5", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10537652", "map_id": "none", "name": "5-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by PPIP5K1/2 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10537649", "map_id": "none", "name": "PPIP5K1/2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P91309", "map_id": "P91309", "name": "PPIP5K2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018508", "map_id": "WBGene00018508", "name": "PPIP5K2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10537758", "map_id": "none", "name": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/3 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10537726", "map_id": "none", "name": "IP6 is phosphorylated to 1-PP-IP5 by PPIP5K1/2 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10537598", "map_id": "none", "name": "(PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10537663", "map_id": "none", "name": "1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1629738", "map_id": "CHEBI:62931", "name": "1,5-(PP)2-IP3", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10555333", "map_id": "none", "name": "MIOX oxidises Ins to GlcA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_2162232", "map_id": "CHEBI:15748", "name": "GlcA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10555330", "map_id": "none", "name": "MIOX:2xFe2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q65CM5", "map_id": "Q65CM5", "name": "MIOX", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016920", "map_id": "WBGene00016920", "name": "MIOX", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10537637", "map_id": "none", "name": "I(1,3,4)P3 is dephosphorylated to I(1,3)P2 by INPP4A/B in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1629769", "map_id": "CHEBI:18225", "name": "I(1,3)P2", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10537606", "map_id": "none", "name": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1629739", "map_id": "CHEBI:17816", "name": "I(1,4)P2", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10537686", "map_id": "none", "name": "I3P is dephosphorylated to Ins by IMPA1/2 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1629731", "map_id": "CHEBI:18169", "name": "I3P", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10537530", "map_id": "none", "name": "IMPA1/2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q19420", "map_id": "Q19420", "name": "ttx-7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008765", "map_id": "WBGene00008765", "name": "ttx-7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10537672", "map_id": "none", "name": "I(3,4)P2 is dephosphorylated to I3P by INPP4A/B in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1629746", "map_id": "CHEBI:28858", "name": "I(3,4)P2", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10537689", "map_id": "none", "name": "I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1629753", "map_id": "CHEBI:18384", "name": "I4P", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10537755", "map_id": "none", "name": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10537752", "map_id": "none", "name": "INPP5A/B", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q17848", "map_id": "Q17848", "name": "ipp-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002146", "map_id": "WBGene00002146", "name": "ipp-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10537533", "map_id": "none", "name": "I1P is dephosphorylated to Ins by IMPA1/2 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_870330", "map_id": "CHEBI:18297", "name": "I1P", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10537629", "map_id": "none", "name": "Glc6P is isomerised to I3P by ISYNA1 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1629756", "map_id": "CHEBI:4170", "name": "Glc6P", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10537626", "map_id": "none", "name": "ISYNA1:NAD+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "G5ED01", "map_id": "G5ED01", "name": "inos-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012148", "map_id": "WBGene00012148", "name": "inos-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10520816", "map_id": "none", "name": "FAR1 reduces PalmCoA to HXOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_8848577", "map_id": "CHEBI:16125", "name": "HXOL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10520813", "map_id": "Q9TZL9", "name": "fard-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane", "complex": "false" }, { "id": "WBGene00022200", "map_id": "WBGene00022200", "name": "fard-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10564721", "map_id": "none", "name": "AWAT2 transfers PALM from PALM-CoA to HXOL, forming palmityl palmitate ester", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_8848499", "map_id": "CHEBI:75584", "name": "PALM-PALM", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10564724", "map_id": "none", "name": "AWAT2 transfers PALM from PALM-CoA to atROL, forming atR-PALM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_30209", "map_id": "CHEBI:17336", "name": "atROL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10557631", "map_id": "none", "name": "AWAT1 transfers acyl group from acyl-CoA to ARACOH, forming wax esters", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_192172", "map_id": "CHEBI:17984", "name": "Acyl-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_5696426", "map_id": "CHEBI:75627", "name": "ARACOH", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_5696412", "map_id": "CHEBI:10036", "name": "arachidyl ester", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10557628", "map_id": "none", "name": "Homologues of AWAT1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10520819", "map_id": "none", "name": "1-palmitoylglycerone phosphate + hexadecanol => O-hexadecylglycerone phosphate + palmitate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_390440", "map_id": "CHEBI:16125", "name": "HXOL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_390419", "map_id": "CHEBI:17868", "name": "1-Palmitoyl dihydroxyacetone phosphate", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_390409", "map_id": "CHEBI:17197", "name": "GO3P", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_10507473", "map_id": "none", "name": "GNPAT:AGPS complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "true" }, { "id": "O45218", "map_id": "O45218", "name": "ads-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000081", "map_id": "WBGene00000081", "name": "ads-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10507476", "map_id": "none", "name": "palmitoyl-CoA + DHAP => 1-palmitoylglycerone phosphate + CoASH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_390426", "map_id": "CHEBI:15525", "name": "PalmCoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_390404", "map_id": "CHEBI:57642", "name": "DHAP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "reaction_10507484", "map_id": "none", "name": "DHRS7B reduces GO3P to HXDG3P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_390422", "map_id": "CHEBI:63818", "name": "HXDG3P", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10507481", "map_id": "Q65ZI3", "name": "dhs-30", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane", "complex": "false" }, { "id": "WBGene00000993", "map_id": "WBGene00000993", "name": "dhs-30", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10537136", "map_id": "none", "name": "PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10537133", "map_id": "none", "name": "PI4KA/2B", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10563689", "map_id": "none", "name": "SBF1 binds MTMR2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10563685", "map_id": "Q9TXP3", "name": "mtm-5", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "WBGene00003477", "map_id": "WBGene00003477", "name": "mtm-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10537108", "map_id": "Q9N589", "name": "mtm-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10563687", "map_id": "none", "name": "MTMR2:SBF1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q9TXP3", "map_id": "Q9TXP3", "name": "mtm-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10537277", "map_id": "none", "name": "PI4P is dephosphorylated to PI by SACM1L at the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10537274", "map_id": "Q93641", "name": "sac-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "reaction_10563692", "map_id": "none", "name": "PI3P is dephosphorylated to PI by MTMR2:SBF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10563695", "map_id": "none", "name": "PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_6809774", "map_id": "CHEBI:16851", "name": "PI(3,5)P2", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_422529", "map_id": "CHEBI:16500", "name": "PI5P", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "reaction_10537328", "map_id": "none", "name": "PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A at the early endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_171062", "compartment_display": "early endosome membrane" }, { "id": "species_1806180", "map_id": "CHEBI:17526", "name": "PI4P", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_171062", "compartment_display": "early endosome membrane", "complex": "false" }, { "id": "species_1806238", "map_id": "CHEBI:16152", "name": "PI(3,4)P2", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_171062", "compartment_display": "early endosome membrane", "complex": "false" }, { "id": "species_10537178", "map_id": "none", "name": "PIK3C2A:Ca2+/Mg2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10563680", "map_id": "none", "name": "PI3P is dephosphorylated to PI by MTM1:MTMR12", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_171062", "compartment_display": "early endosome membrane" }, { "id": "species_1806199", "map_id": "CHEBI:16749", "name": "PI", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_171062", "compartment_display": "early endosome membrane", "complex": "false" }, { "id": "species_10563671", "map_id": "none", "name": "MTM1:MTMR12", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "V6CJW9", "map_id": "V6CJW9", "name": "MTMR12", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021683", "map_id": "WBGene00021683", "name": "MTMR12", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10537219", "map_id": "none", "name": "PI is phosphorylated to PI4P by PI4K2A/B at the early endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_171062", "compartment_display": "early endosome membrane" }, { "id": "reaction_10537286", "map_id": "none", "name": "PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_171062", "compartment_display": "early endosome membrane" }, { "id": "species_10537252", "map_id": "none", "name": "MTM1,MTMR2,MTMR4", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10537255", "map_id": "none", "name": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_171062", "compartment_display": "early endosome membrane" }, { "id": "species_1806205", "map_id": "CHEBI:16851", "name": "PI(3,5)P2", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_171062", "compartment_display": "early endosome membrane", "complex": "false" }, { "id": "species_1806259", "map_id": "CHEBI:16500", "name": "PI5P", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_171062", "compartment_display": "early endosome membrane", "complex": "false" }, { "id": "reaction_10563673", "map_id": "none", "name": "MTMR12 binds MTM1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10563669", "map_id": "V6CJW9", "name": "MTMR12", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10537106", "map_id": "Q9N589", "name": "mtm-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10537196", "map_id": "none", "name": "PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_171062", "compartment_display": "early endosome membrane" }, { "id": "reaction_10563677", "map_id": "none", "name": "MTMR12 binds MTMR2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10563675", "map_id": "none", "name": "MTMR2:MTMR12", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10537310", "map_id": "none", "name": "PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_171062", "compartment_display": "early endosome membrane" }, { "id": "reaction_10564974", "map_id": "none", "name": "PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_8849959", "map_id": "none", "name": "PI(4,5)P2, PI(3,4)P2, PI(3,4,5)P3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_171062", "compartment_display": "early endosome membrane", "complex": "true" }, { "id": "species_8849958", "map_id": "none", "name": "PI5P, PI3P, PI(3,5)P2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_171062", "compartment_display": "early endosome membrane", "complex": "true" }, { "id": "species_10564971", "map_id": "Q9U330", "name": "INPP5F", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_171062", "compartment_display": "early endosome membrane", "complex": "false" }, { "id": "WBGene00012353", "map_id": "WBGene00012353", "name": "INPP5F", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10564261", "map_id": "none", "name": "PNPLA6 hydrolyzes LysoPtdCho", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_6814253", "map_id": "CHEBI:58168", "name": "LysoPtdCho", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_1498750", "map_id": "CHEBI:16870", "name": "GPCho", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10564258", "map_id": "none", "name": "Homologues of PNPLA6", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q21534", "map_id": "Q21534", "name": "PNPLA6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022718", "map_id": "WBGene00022718", "name": "PNPLA6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q02331", "map_id": "Q02331", "name": "PNPLA6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10564484", "map_id": "none", "name": "ENPP6 hydrolyzes lysophosphatidylcholine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_2239407", "map_id": "CHEBI:60479", "name": "lysophosphatidylcholine", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_6814794", "map_id": "CHEBI:18132", "name": "ChoP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10564481", "map_id": "none", "name": "Homologues of ENPP6", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10564134", "map_id": "none", "name": "GDE1 hydrolyzes GroPIns", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_6813734", "map_id": "CHEBI:58444", "name": "GroPIns", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10564131", "map_id": "Q9UAW8", "name": "GDE1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "WBGene00020446", "map_id": "WBGene00020446", "name": "GDE1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10542310", "map_id": "none", "name": "Desaturation of dihomo-gamma-lenolenoyl-CoA to arachidonoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_2046045", "map_id": "CHEBI:27979", "name": "DGL-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_2046053", "map_id": "CHEBI:15514", "name": "AA-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "reaction_10542312", "map_id": "none", "name": "Translocation of tetracosapentaenoyl-CoA to peroxisomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_2046050", "map_id": "CHEBI:63546", "name": "TPA-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_5228339", "map_id": "CHEBI:43474", "name": "Pi", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_2046055", "map_id": "CHEBI:63546", "name": "TPA-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "reaction_10542314", "map_id": "none", "name": "Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_2046042", "map_id": "CHEBI:15508", "name": "GLA-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "reaction_10542316", "map_id": "none", "name": "Desaturation of Linoleoyl-CoA to gamma-linolenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_2046063", "map_id": "CHEBI:15530", "name": "LA-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "reaction_10542318", "map_id": "none", "name": "Desaturation of tetracosatetraenoyl-CoA to tetracosapentaenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_2046048", "map_id": "CHEBI:63548", "name": "TTA-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "reaction_10557520", "map_id": "none", "name": "ACAD11 dehydrogenates BH-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_5695963", "map_id": "CHEBI:65088", "name": "BH-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_5695976", "map_id": "CHEBI:85880", "name": "DHB-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10557517", "map_id": "O01590", "name": "acds-10", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "WBGene00019599", "map_id": "WBGene00019599", "name": "acds-10", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10556512", "map_id": "none", "name": "Cytosolic ACOTs hydrolyse MCFA-CoA, LCFA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5690044", "map_id": "none", "name": "MCFA-CoA, LCFA-CoA", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_5690064", "map_id": "none", "name": "MCFA, LCFA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10556509", "map_id": "none", "name": "Cytosolic ACOTs, THEM4", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P34419", "map_id": "P34419", "name": "ACOT13", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018370", "map_id": "WBGene00018370", "name": "ACOT13", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10567219", "map_id": "none", "name": "ACAA2 tetramer transfers acyl group from Ac-CoA to acyl-CoA forming 3OA-CoA and CoA-SH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_8874749", "map_id": "CHEBI:15489", "name": "3OA-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10567216", "map_id": "none", "name": "ACAA2 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "O45552", "map_id": "O45552", "name": "acaa-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009952", "map_id": "WBGene00009952", "name": "acaa-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10564674", "map_id": "none", "name": "ACBD6 binds LCFA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10564670", "map_id": "Q9XVJ0", "name": "acbp-5", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00011731", "map_id": "WBGene00011731", "name": "acbp-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10564672", "map_id": "none", "name": "ACBD6:LCFA-CoA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9XVJ0", "map_id": "Q9XVJ0", "name": "acbp-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10564645", "map_id": "none", "name": "DBI, ACBD7 bind MCFA-CoA and LCFA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_8848288", "map_id": "none", "name": "MCFA-CoA, LCFA-CoA", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "species_10564641", "map_id": "none", "name": "DBI, (ACBD7)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "Q09603", "map_id": "Q09603", "name": "ech-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001153", "map_id": "WBGene00001153", "name": "ech-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10564643", "map_id": "none", "name": "DBI,ACBD7:MCFA-CoA,LCFA-CoA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "reaction_10556532", "map_id": "none", "name": "ACOT2,9,THEM4,5 hydrolyse MCFA-CoA, LCFA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_5690540", "map_id": "none", "name": "MCFA-CoA, LCFA-CoA", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "species_5690519", "map_id": "none", "name": "MCFA, LCFA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "species_10556529", "map_id": "none", "name": "ACOT2,9, THEM4,5 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q94245", "map_id": "Q94245", "name": "ACOT9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019015", "map_id": "WBGene00019015", "name": "ACOT9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10503674", "map_id": "none", "name": "D-methylmalonyl-CoA <=> L-methylmalonyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_71019", "map_id": "CHEBI:15466", "name": "MEMA-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10503671", "map_id": "G5EEG4", "name": "mce-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "WBGene00008415", "map_id": "WBGene00008415", "name": "mce-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10503692", "map_id": "none", "name": "propionyl-CoA + CO2 + ATP <=> D-methylmalonyl-CoA + ADP + orthophosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10503689", "map_id": "none", "name": "6x(Btn-PCCA:PCCB)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "reaction_10508264", "map_id": "none", "name": "Octanoyl-CoA+FAD<=>trans-Oct-2-enoyl-CoA+FADH2", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_77337", "map_id": "CHEBI:15533", "name": "Octanoyl-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_77332", "map_id": "CHEBI:27537", "name": "trans-Oct-2-enoyl-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10508261", "map_id": "none", "name": "ACADM tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q22347", "map_id": "Q22347", "name": "acdh-10", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020366", "map_id": "WBGene00020366", "name": "acdh-10", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10508250", "map_id": "none", "name": "3-Oxooctanoyl-CoA+CoA-SH<=>Hexanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_77328", "map_id": "CHEBI:28264", "name": "3-Oxooctanoyl-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_77326", "map_id": "CHEBI:27540", "name": "HX-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10508252", "map_id": "none", "name": "(S)-Hydroxyoctanoyl-CoA+NAD<=>3-Oxooctanoyl-CoA+NADH+H", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_77330", "map_id": "CHEBI:28632", "name": "(S)-Hydroxyoctanoyl-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10508254", "map_id": "none", "name": "trans-Oct-2-enoyl-CoA+H2O<=>(S)-Hydroxyoctanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "reaction_10508272", "map_id": "none", "name": "Decanoyl-CoA+FAD<=>trans-Dec-2-enoyl-CoA+FADH2", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_77343", "map_id": "CHEBI:10723", "name": "tdec2-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10569787", "map_id": "none", "name": "MECR dimer reduces tdec2-CoA to DEC-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10569784", "map_id": "none", "name": "MECR dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "O45903", "map_id": "O45903", "name": "MECR", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012375", "map_id": "WBGene00012375", "name": "MECR", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10508266", "map_id": "none", "name": "3-Oxodecanoyl-CoA+CoA-SH<=>Octanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_77339", "map_id": "CHEBI:28528", "name": "3-Oxodecanoyl-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10508268", "map_id": "none", "name": "(S)-Hydroxydecanoyl-CoA+NAD<=>3-Oxodecanoyl-CoA+NADH+H", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_77341", "map_id": "CHEBI:28325", "name": "(S)-Hydroxydecanoyl-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10508270", "map_id": "none", "name": "trans-Dec-2-enoyl-CoA+H2O<=>(S)-Hydroxydecanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "reaction_10508230", "map_id": "none", "name": "palmitoyl-CoA+FAD<=>trans-Hexadec-2-enoyl-CoA+FADH2", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_77284", "map_id": "CHEBI:28935", "name": "trans-Hexadec-2-enoyl-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10508227", "map_id": "none", "name": "ACADVL dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q19057", "map_id": "Q19057", "name": "acdh-12", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017125", "map_id": "WBGene00017125", "name": "acdh-12", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10508232", "map_id": "none", "name": "trans-Hexadec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxyhexadecanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_77300", "map_id": "CHEBI:27402", "name": "(S)-3-Hydroxyhexadecanoyl-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10508234", "map_id": "none", "name": "(S)-3-Hydroxyhexadecanoyl-CoA+NAD<=>3-Oxopalmitoyl-CoA+NADH+H", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_77302", "map_id": "CHEBI:15491", "name": "3-Oxopalmitoyl-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10508236", "map_id": "none", "name": "3-Oxopalmitoyl-CoA+CoA-SH<=>myristoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_77272", "map_id": "CHEBI:15532", "name": "MYS-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10557528", "map_id": "none", "name": "ACSF2 ligates CoA-SH to MCFA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10557525", "map_id": "Q9UAV8", "name": "acs-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "WBGene00018488", "map_id": "WBGene00018488", "name": "acs-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10508370", "map_id": "none", "name": "dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_109986", "map_id": "CHEBI:29140", "name": "4-cis-decenoyl-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_109990", "map_id": "CHEBI:29119", "name": "2-trans-4-cis-decadienoyl-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10508380", "map_id": "none", "name": "Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_109994", "map_id": "CHEBI:29126", "name": "3-trans-decenoyl-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10508377", "map_id": "none", "name": "DECR1 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q23116", "map_id": "Q23116", "name": "decr-1.2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012177", "map_id": "WBGene00012177", "name": "decr-1.2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10542993", "map_id": "none", "name": "Arachidonic acid is hydroxylated to 19-HETE by CYP(2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_2142836", "map_id": "CHEBI:63998", "name": "19-HETE", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10542990", "map_id": "none", "name": "CYP(2)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10543003", "map_id": "none", "name": "Arachidonic acid is hydroxylated to 20-HETE by CYP(3)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_2142780", "map_id": "CHEBI:34306", "name": "20-HETE", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10543000", "map_id": "none", "name": "CYP(3)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10557108", "map_id": "none", "name": "FAAH hydrolyses AEA to AA and ETA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_5693754", "map_id": "CHEBI:2700", "name": "AEA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10557105", "map_id": "none", "name": "Homologues of FAAH", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q17449", "map_id": "Q17449", "name": "faah-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00015047", "map_id": "WBGene00015047", "name": "faah-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9U217", "map_id": "Q9U217", "name": "faah-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013232", "map_id": "WBGene00013232", "name": "faah-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O45089", "map_id": "O45089", "name": "faah-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019068", "map_id": "WBGene00019068", "name": "faah-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q17447", "map_id": "Q17447", "name": "faah-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00015048", "map_id": "WBGene00015048", "name": "faah-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9U243", "map_id": "Q9U243", "name": "faah-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013226", "map_id": "WBGene00013226", "name": "faah-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9U2I8", "map_id": "Q9U2I8", "name": "faah-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012750", "map_id": "WBGene00012750", "name": "faah-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10568057", "map_id": "none", "name": "PON1,2,3:Ca2+ dimers hydrolyse 5-HETEL to 5-HETE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_8932801", "map_id": "CHEBI:132873", "name": "5-HETEL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_8932804", "map_id": "CHEBI:60943", "name": "5-HETE", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10568054", "map_id": "none", "name": "PON1,2,3:2xCa2+ dimers", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "B1V898", "map_id": "B1V898", "name": "poml-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00077701", "map_id": "WBGene00077701", "name": "poml-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O01811", "map_id": "O01811", "name": "mec-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003170", "map_id": "WBGene00003170", "name": "mec-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q21427", "map_id": "Q21427", "name": "poml-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010775", "map_id": "WBGene00010775", "name": "poml-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q2V071", "map_id": "Q2V071", "name": "poml-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00044697", "map_id": "WBGene00044697", "name": "poml-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q966L1", "map_id": "Q966L1", "name": "poml-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017089", "map_id": "WBGene00017089", "name": "poml-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10517856", "map_id": "none", "name": "LTC4 is exported from the cytosol by ABCC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_266066", "map_id": "CHEBI:16978", "name": "LTC4", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10517848", "map_id": "none", "name": "GGT1, 5 dimers hydrolyse LTC4 to LTD4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10517845", "map_id": "none", "name": "GGT1, 5 dimers", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10542985", "map_id": "none", "name": "20oh-LTB4 is oxidised to 20cho-LTB4 by CYP4F2/4F3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_2142740", "map_id": "CHEBI:63979", "name": "20cho-LTB4", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10517866", "map_id": "none", "name": "LTA4 is hydolysed to LTB4 by LTA4H", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_265281", "map_id": "CHEBI:15651", "name": "LTA4", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10542988", "map_id": "none", "name": "20cho-LTB4 is oxidised to 20cooh-LTB4 by CYP4F2/4F3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_2161582", "map_id": "CHEBI:27562", "name": "20cooh-LTB4", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10543012", "map_id": "none", "name": "12R-HpETE is reduced to 12R-HETE by GPX1/2/4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_2142790", "map_id": "CHEBI:34145", "name": "12R-HpETE", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_2142716", "map_id": "CHEBI:34144", "name": "12R-HETE", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10543009", "map_id": "A8WFK6", "name": "gpx-7", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10543014", "map_id": "none", "name": "12S-HpETE is reduced to 12S-HETE by GPX1/2/4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_2142811", "map_id": "CHEBI:15626", "name": "12S-HpETE", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_2142678", "map_id": "CHEBI:34146", "name": "12S-HETE", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10557116", "map_id": "none", "name": "FAAH2 hydrolyses AEA to AA and ETA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13977", "compartment_display": "lipid droplet" }, { "id": "species_5693747", "map_id": "CHEBI:15377", "name": "H2O", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_13977", "compartment_display": "lipid droplet", "complex": "false" }, { "id": "species_5693736", "map_id": "CHEBI:16000", "name": "ETA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_13977", "compartment_display": "lipid droplet", "complex": "false" }, { "id": "species_5693733", "map_id": "CHEBI:15843", "name": "AA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_13977", "compartment_display": "lipid droplet", "complex": "false" }, { "id": "species_10557113", "map_id": "Q9NAB7", "name": "FAAH2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_13977", "compartment_display": "lipid droplet", "complex": "false" }, { "id": "WBGene00013164", "map_id": "WBGene00013164", "name": "FAAH2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10506598", "map_id": "none", "name": "acetoacetyl-CoA + CoA <=> 2 acetyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "reaction_10506586", "map_id": "none", "name": "OXCT dimers transfer CoA from SUCC-CoA to ACA, forming ACA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_73909", "map_id": "CHEBI:15344", "name": "ACA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10506583", "map_id": "none", "name": "OXCT dimers", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q09450", "map_id": "Q09450", "name": "OXCT2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007330", "map_id": "WBGene00007330", "name": "OXCT2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10506419", "map_id": "none", "name": "acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_73917", "map_id": "CHEBI:15467", "name": "HMG CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10506416", "map_id": "P54871", "name": "hmgs-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10506596", "map_id": "none", "name": "HMG CoA => acetoacetic acid + acetyl CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10506593", "map_id": "none", "name": "HMGCL dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "reaction_10557499", "map_id": "none", "name": "AACS ligates CoA-SH to ACA, forming ACA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10557496", "map_id": "Q21166", "name": "sur-5", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00006351", "map_id": "WBGene00006351", "name": "sur-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10558315", "map_id": "none", "name": "HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10558312", "map_id": "none", "name": "HMGCLL1:Mg2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10536353", "map_id": "none", "name": "Beta-galactosidase hydrolyses GM1 to GM2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_1605677", "map_id": "CHEBI:61048", "name": "GM1", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "false" }, { "id": "species_1605610", "map_id": "CHEBI:51013", "name": "GM2", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "reaction_10536324", "map_id": "none", "name": "Glucosylceramidase cleaves the glucosidic bond of glucocerebroside to form ceramide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane" }, { "id": "species_1605592", "map_id": "CHEBI:18368", "name": "Glucosylceramide", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_1605745", "map_id": "CHEBI:17925", "name": "Glc", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_1605673", "map_id": "CHEBI:52639", "name": "CERA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_10536321", "map_id": "none", "name": "GBA:SAPC", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "G5ECR8", "map_id": "G5ECR8", "name": "gba-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008706", "map_id": "WBGene00008706", "name": "gba-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10536360", "map_id": "none", "name": "Both hexosaminidase A and B can cleave GalNAc from globoside", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_1605608", "map_id": "CHEBI:61360", "name": "Globoside", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_1605716", "map_id": "CHEBI:18313", "name": "Gb3Cer", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_10536357", "map_id": "none", "name": "HEXA,B", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "true" }, { "id": "reaction_10536680", "map_id": "none", "name": "Ectonucleotide pyrophosphatase/phosphodiesterase 7 (ENPP7) hydrolyses sphingomyelin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_429776", "map_id": "CHEBI:17636", "name": "SPHM", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_429807", "map_id": "CHEBI:17761", "name": "CERA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_1610735", "map_id": "CHEBI:18132", "name": "ChoP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10536677", "map_id": "none", "name": "Homologues of ENPP7", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10537833", "map_id": "none", "name": "Glucosylceramidase 2 cleaves the glucosidic bond of glucocerebroside to form ceramide (plasma membrane)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_1861782", "map_id": "CHEBI:18368", "name": "Glucosylceramide", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10537830", "map_id": "O01893", "name": "GBA2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "WBGene00019965", "map_id": "WBGene00019965", "name": "GBA2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10536363", "map_id": "none", "name": "Ganglioside GM2 activator presents GM2 to hexosaminidase for cleavage", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_10536329", "map_id": "O02106", "name": "mlt-8", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_10536331", "map_id": "none", "name": "GM2A:GM2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "true" }, { "id": "reaction_10536427", "map_id": "none", "name": "Sphingomyelin phosphodiesterase 2 and 3 (SMPD2 and 3) hydrolyse sphingomyelin to ceramide (plasma membrane)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10536424", "map_id": "none", "name": "SMPD2,3:Mg2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "O45870", "map_id": "O45870", "name": "SMPD2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012105", "map_id": "WBGene00012105", "name": "SMPD2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10536459", "map_id": "none", "name": "Acid ceramidase hydrolyses ceramide into sphingosine and free fatty acid (lysosome)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_1861779", "map_id": "CHEBI:33575", "name": "RCOOH", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_1606588", "map_id": "CHEBI:16393", "name": "SPG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_10536456", "map_id": "none", "name": "ASAH1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "true" }, { "id": "reaction_10536652", "map_id": "none", "name": "Ceramide glucosyltransferase (UGCG) catalyses the transfer of glucose to ceramide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_744227", "map_id": "CHEBI:18066", "name": "UDP-Glc", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_428270", "map_id": "CHEBI:17761", "name": "CERA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "species_1660674", "map_id": "CHEBI:18368", "name": "Glucosylceramide", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10536649", "map_id": "G5EC84", "name": "cgt-2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "WBGene00017625", "map_id": "WBGene00017625", "name": "cgt-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10567887", "map_id": "none", "name": "B3GALNT1 transfer GalNAc to Gb3Cer to form Gb4Cer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "species_8879102", "map_id": "CHEBI:18313", "name": "Gb3Cer", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "species_8879101", "map_id": "CHEBI:18259", "name": "Gb4Cer", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "species_10567884", "map_id": "Q95US5", "name": "bre-5", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "WBGene00000270", "map_id": "WBGene00000270", "name": "bre-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10558126", "map_id": "none", "name": "UGT8 transfers Gal from UDP-Gal to CERA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29452", "map_id": "CHEBI:18307", "name": "UDP-Gal", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_6785915", "map_id": "CHEBI:18390", "name": "GalCer", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10558123", "map_id": "Q22770", "name": "ugt-54", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "WBGene00012013", "map_id": "WBGene00012013", "name": "ugt-54", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10537842", "map_id": "none", "name": "Glucosylceramidase 3 cleaves the glucosidic bond of glucocerebroside to form ceramide (cytosol)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1861764", "map_id": "CHEBI:18368", "name": "Glucosylceramide", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_194377", "map_id": "CHEBI:52639", "name": "N-acylsphingosine", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10537839", "map_id": "none", "name": "Homologues of GBA3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q18758", "map_id": "Q18758", "name": "klo-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016848", "map_id": "WBGene00016848", "name": "klo-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9TZA0", "map_id": "Q9TZA0", "name": "klo-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017103", "map_id": "WBGene00017103", "name": "klo-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10551475", "map_id": "none", "name": "GLTPD1 transports C1P from plasma membrane to Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1638840", "map_id": "CHEBI:16197", "name": "C1P", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_5339515", "map_id": "CHEBI:16197", "name": "C1P", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "species_10551472", "map_id": "A0A3P6NP42", "name": "tag-296", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00018632", "map_id": "WBGene00018632", "name": "tag-296", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10536660", "map_id": "none", "name": "CERK phosphorylates CERA to form C1P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10536657", "map_id": "Q9TZI1", "name": "cerk-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "WBGene00020398", "map_id": "WBGene00020398", "name": "cerk-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10536373", "map_id": "none", "name": "Alpha-galactosidase A removes a terminal galactose from alpha-D-galactoside oligomers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_1605601", "map_id": "CHEBI:17950", "name": "LacCer", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_10536370", "map_id": "none", "name": "GLA dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "true" }, { "id": "reaction_10536437", "map_id": "none", "name": "Sphingomyelin phosphodiesterase 4 (SMPD4) hydrolyses sphingomyelin to ceramide (ER membrane)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_1606283", "map_id": "CHEBI:17636", "name": "SPHM", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_428256", "map_id": "CHEBI:17761", "name": "CERA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_1606280", "map_id": "CHEBI:18132", "name": "ChoP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10536434", "map_id": "none", "name": "SMPD4:Mg2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q95ZR2", "map_id": "Q95ZR2", "name": "SMPD4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011037", "map_id": "WBGene00011037", "name": "SMPD4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10536439", "map_id": "none", "name": "Beta-galactosidase can also hydrolyse globosides to form cerebrosides", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "reaction_10536345", "map_id": "none", "name": "Hexosaminidase A cleaves GalNAc from GM2 to form GM3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_1605641", "map_id": "CHEBI:15681", "name": "GM3", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "reaction_10536381", "map_id": "none", "name": "Sphingomyelin phosphodiesterase (SMPD1) hydrolyses sphingomyelin to ceramide (lysosome)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_1605713", "map_id": "CHEBI:17636", "name": "SPHM", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_1605750", "map_id": "CHEBI:18132", "name": "ChoP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_10536378", "map_id": "Q23498", "name": "asm-2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "WBGene00000212", "map_id": "WBGene00000212", "name": "asm-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10551516", "map_id": "none", "name": "GLTP transports GSL from plasma membrane to ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_5340315", "map_id": "CHEBI:24402", "name": "GSL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_5340299", "map_id": "CHEBI:24402", "name": "GSL", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10551513", "map_id": "Q9BKS2", "name": "GLTP", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10565820", "map_id": "none", "name": "ESYT1:ESYT2:ESYT3 transport GPL from plasma membrane to ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_8857646", "map_id": "CHEBI:37739", "name": "GPL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_8857684", "map_id": "CHEBI:37739", "name": "GPL", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10565817", "map_id": "none", "name": "ESYT1:ESYT2:ESYT3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10536447", "map_id": "none", "name": "Galactocerebrosidase cleaves the galactosyl bond of galactocerebroside to form ceramide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_1606573", "map_id": "CHEBI:18390", "name": "GalCer", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_10536444", "map_id": "Q95QT2", "name": "GALC", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "WBGene00016207", "map_id": "WBGene00016207", "name": "GALC", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10523456", "map_id": "none", "name": "PRKD1,2,3 phosphorylates COL4A3BP-2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10523428", "map_id": "Q93569", "name": "COL4A3BP-2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00009120", "map_id": "WBGene00009120", "name": "phospho-p-S,S132,T-COL4A3BP-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10523431", "map_id": "Q93569", "name": "phospho-p-S132-COL4A3BP-2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10523453", "map_id": "none", "name": "PRKD1,2,3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9XUJ7", "map_id": "Q9XUJ7", "name": "dkf-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012352", "map_id": "WBGene00012352", "name": "dkf-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O45818", "map_id": "O45818", "name": "dkf-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012019", "map_id": "WBGene00012019", "name": "dkf-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10556864", "map_id": "none", "name": "ALDH3A2-1 oxidises HD2NAL to PALM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_428671", "map_id": "CHEBI:17585", "name": "HD2NAL", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10556861", "map_id": "none", "name": "ALDH3A2-1 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10523106", "map_id": "none", "name": "sphinganine (dihydrosphingosine) +ATP => sphinganine 1-phosphate + ADP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_428163", "map_id": "CHEBI:16566", "name": "SPA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_428275", "map_id": "CHEBI:16893", "name": "SPAP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10570149", "map_id": "none", "name": "SAMD8 transforms PE and CERA to CPE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_8959486", "map_id": "CHEBI:17761", "name": "CERA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_8959463", "map_id": "CHEBI:73204", "name": "CPE", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10570146", "map_id": "Q20696", "name": "SAMD8", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "WBGene00018735", "map_id": "WBGene00018735", "name": "SAMD8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10557124", "map_id": "none", "name": "FA2H hydroxylates CERA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_5693768", "map_id": "CHEBI:85781", "name": "2HCERA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10557121", "map_id": "Q9XVS0", "name": "fath-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "WBGene00007707", "map_id": "WBGene00007707", "name": "fath-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10523111", "map_id": "none", "name": "ceramide + H2O <=> stearate + sphingosine [endoplasmic reticulum]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_428193", "map_id": "CHEBI:16393", "name": "SPG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_428198", "map_id": "CHEBI:9254", "name": "STEA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17941", "compartment_display": "early endosome", "complex": "false" }, { "id": "species_10523108", "map_id": "O45145", "name": "ACER1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "WBGene00020947", "map_id": "WBGene00020947", "name": "ACER2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10523207", "map_id": "none", "name": "sphingosine 1-phosphate => phosphoethanolamine + hexadec-2-enal", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_428203", "map_id": "CHEBI:37550", "name": "S1P", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10523204", "map_id": "Q9Y194", "name": "spl-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "WBGene00004981", "map_id": "WBGene00004981", "name": "spl-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10563430", "map_id": "none", "name": "ALDH3B2 oxidises HXAL to PALM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13977", "compartment_display": "lipid droplet" }, { "id": "species_6808468", "map_id": "CHEBI:17600", "name": "HXAL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_13977", "compartment_display": "lipid droplet", "complex": "false" }, { "id": "species_2453691", "map_id": "CHEBI:15756", "name": "PALM", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_13977", "compartment_display": "lipid droplet", "complex": "false" }, { "id": "species_10563427", "map_id": "none", "name": "Homologues of ALDH3B2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_13977", "compartment_display": "lipid droplet", "complex": "true" }, { "id": "reaction_10523209", "map_id": "none", "name": "sphinganine 1-phosphate => phosphoethanolamine + hexadecanal", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_428663", "map_id": "CHEBI:17600", "name": "HXAL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10523051", "map_id": "none", "name": "3-ketosphinganine + NADPH + H+ => sphinganine + NADP+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_428182", "map_id": "CHEBI:17862", "name": "3-ketosphinganine", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10523048", "map_id": "U4PBL3", "name": "KDSR", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "WBGene00021367", "map_id": "WBGene00021367", "name": "KDSR", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10523468", "map_id": "none", "name": "monophospho-CERT + 2 ATP => multiphospho-CERT + 2 ADP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10523460", "map_id": "Q93569", "name": "phospho-p-S,S132,T-COL4A3BP-2", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10523465", "map_id": "Q8WQ99", "name": "csnk-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00013709", "map_id": "WBGene00013709", "name": "csnk-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10523217", "map_id": "none", "name": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [extracellular]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_419305", "map_id": "CHEBI:37550", "name": "S1P", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_428662", "map_id": "CHEBI:16393", "name": "SPG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10523214", "map_id": "H2KZD1", "name": "plpp-1.1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "WBGene00018756", "map_id": "WBGene00018756", "name": "plpp-1.1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10523251", "map_id": "none", "name": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - PPAP]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_428682", "map_id": "CHEBI:16393", "name": "SPG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10523248", "map_id": "none", "name": "PPAP2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q22250", "map_id": "Q22250", "name": "plpr-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011524", "map_id": "WBGene00011524", "name": "plpr-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "H2KZD1", "map_id": "H2KZD1", "name": "plpp-1.1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q10022", "map_id": "Q10022", "name": "plpp-1.2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020895", "map_id": "WBGene00020895", "name": "plpp-1.2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q19403", "map_id": "Q19403", "name": "plpp-1.3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008749", "map_id": "WBGene00008749", "name": "plpp-1.3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10573237", "map_id": "none", "name": "SPNS2 transports S1P from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10573234", "map_id": "none", "name": "Homologues of SPNS2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "A0A3B1DV80", "map_id": "A0A3B1DV80", "name": "spin-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013739", "map_id": "WBGene00013739", "name": "spin-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q19235", "map_id": "Q19235", "name": "spin-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008598", "map_id": "WBGene00008598", "name": "spin-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O01927", "map_id": "O01927", "name": "spin-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007549", "map_id": "WBGene00007549", "name": "spin-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q18545", "map_id": "Q18545", "name": "spin-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008033", "map_id": "WBGene00008033", "name": "spin-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10523509", "map_id": "none", "name": "phosphatidylcholine + ceramide <=> sphingomyelin + diacylglycerol [SGMS2]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10523506", "map_id": "none", "name": "Homologues of 2xPalmC-SGMS2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9U3D4", "map_id": "Q9U3D4", "name": "sms-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004892", "map_id": "WBGene00004892", "name": "sms-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q965Q4", "map_id": "Q965Q4", "name": "sms-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004894", "map_id": "WBGene00004894", "name": "sms-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9TYV2", "map_id": "Q9TYV2", "name": "sms-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021075", "map_id": "WBGene00021075", "name": "sms-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q20735", "map_id": "Q20735", "name": "sms-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004893", "map_id": "WBGene00004893", "name": "sms-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10523093", "map_id": "none", "name": "sphinganine + stearyl-CoA => dihydroceramide + CoASH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_428126", "map_id": "CHEBI:31488", "name": "DHCE", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10523090", "map_id": "none", "name": "LASS proteins", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q9XWE9", "map_id": "Q9XWE9", "name": "lagr-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006505", "map_id": "WBGene00006505", "name": "lagr-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5ED45", "map_id": "G5ED45", "name": "hyl-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002043", "map_id": "WBGene00002043", "name": "hyl-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7Z139", "map_id": "Q7Z139", "name": "hyl-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002044", "map_id": "WBGene00002044", "name": "hyl-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10523126", "map_id": "none", "name": "dihydroceramide + NAD(P)H + H+ + O2 => ceramide + NAD(P)+ + H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_428206", "map_id": "none", "name": "NAD(P)H", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_428218", "map_id": "none", "name": "NAD(P)+", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10523123", "map_id": "none", "name": "Homologues of DEGS1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10557561", "map_id": "none", "name": "ALDH3B1 oxidises HXAL to PALM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10557558", "map_id": "none", "name": "Homologues of ALDH3B1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10523129", "map_id": "none", "name": "dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9025544", "map_id": "CHEBI:31998", "name": "N-acylphytosphingosine", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "reaction_10523514", "map_id": "none", "name": "phosphatidylcholine + ceramide <=> sphingomyelin + diacylglycerol [SGMS1]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_429773", "map_id": "CHEBI:18035", "name": "DAGs", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "species_429789", "map_id": "CHEBI:17636", "name": "SPHM", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "species_10523511", "map_id": "Q9U3D4", "name": "sms-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "reaction_10573242", "map_id": "none", "name": "SPHK2 phosphorylates SPG to S1P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10523103", "map_id": "Q18425", "name": "sphk-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10573240", "map_id": "none", "name": "SPHK2:SPHK2 inhibitors", "type": "inhibitor", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10523132", "map_id": "none", "name": "SPHK1 phosphorylates SPG to S1P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10523101", "map_id": "none", "name": "ceramide + H2O => stearate + sphingosine [Golgi]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_428248", "map_id": "CHEBI:16393", "name": "SPG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "species_10523098", "map_id": "O45145", "name": "ACER2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "reaction_10536978", "map_id": "none", "name": "S2P hydrolyzes SREBP1A,1C,2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10536972", "map_id": "Q9XX00", "name": "sbp-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "WBGene00004735", "map_id": "WBGene00004735", "name": "sbp-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10536935", "map_id": "Q9XX00", "name": "sbp-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10542407", "map_id": "none", "name": "SREBP1A,1C,2:Importin beta-1 dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10536955", "map_id": "none", "name": "SREBP1A,1C,2:Importin beta-1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9XX00", "map_id": "Q9XX00", "name": "sbp-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10542403", "map_id": "none", "name": "RAN:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10536951", "map_id": "none", "name": "SREBP1A,1C,2 dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10542405", "map_id": "none", "name": "Importin-beta:Ran GTP complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10542409", "map_id": "none", "name": "SREBP1A,1C,2 binds SREBP1A,1C,2 forming dimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10536941", "map_id": "none", "name": "SREBP1A,1C,2 dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10542411", "map_id": "none", "name": "SREBP1A,1C,2 binds Importin beta-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10516892", "map_id": "Q9BIB8", "name": "imb-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10536943", "map_id": "none", "name": "SREBP1A,1C,2:Importin beta-1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10536957", "map_id": "none", "name": "SREBP1A,1C,2 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10557203", "map_id": "none", "name": "EPHX1 hydrates BaP4,5O to BaP4,5-DHD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_5694080", "map_id": "CHEBI:34560", "name": "BaP4,5O", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_5694091", "map_id": "CHEBI:81621", "name": "BaP4,5-DHD", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10557200", "map_id": "Q23068", "name": "EPHX1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "WBGene00020909", "map_id": "WBGene00020909", "name": "EPHX1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10568323", "map_id": "none", "name": "CES3 hydrolyses CHEST to CHOL and LCFA(-)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_163579", "map_id": "CHEBI:17002", "name": "CHEST", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_13977", "compartment_display": "lipid droplet", "complex": "false" }, { "id": "species_216762", "map_id": "CHEBI:16113", "name": "CHOL", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_13946", "compartment_display": "transport vesicle membrane", "complex": "false" }, { "id": "species_10568320", "map_id": "none", "name": "Homologues of CES3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10517444", "map_id": "none", "name": "FMO1:FAD N-oxidises TAM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17960", "compartment_display": "smooth endoplasmic reticulum" }, { "id": "species_159154", "map_id": "CHEBI:41774", "name": "TAM", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_217269", "map_id": "CHEBI:63825", "name": "TAMO", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10517441", "map_id": "none", "name": "FMO1:FAD", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "G5EBJ9", "map_id": "G5EBJ9", "name": "fmo-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001477", "map_id": "WBGene00001477", "name": "fmo-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5ECJ8", "map_id": "G5ECJ8", "name": "fmo-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001478", "map_id": "WBGene00001478", "name": "fmo-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5ED43", "map_id": "G5ED43", "name": "fmo-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001480", "map_id": "WBGene00001480", "name": "fmo-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EDG8", "map_id": "G5EDG8", "name": "fmo-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001479", "map_id": "WBGene00001479", "name": "fmo-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EDP6", "map_id": "G5EDP6", "name": "fmo-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001476", "map_id": "WBGene00001476", "name": "fmo-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10517461", "map_id": "none", "name": "FMO2:FAD:Mg2+ S-oxidises MTZ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17960", "compartment_display": "smooth endoplasmic reticulum" }, { "id": "species_217315", "map_id": "CHEBI:50673", "name": "MTZ", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_217320", "map_id": "CHEBI:63828", "name": "MTZ-SOX", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10517458", "map_id": "none", "name": "FMO2:FAD:Mg2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10509718", "map_id": "none", "name": "FMO3:FAD N-oxidises TMA to TMAO", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_30373", "map_id": "CHEBI:18139", "name": "TMA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_140963", "map_id": "CHEBI:15724", "name": "TMAO", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10509715", "map_id": "none", "name": "FMO3:FAD", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10504257", "map_id": "none", "name": "ethanol + NAD+ => acetaldehyde + NADH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_30203", "map_id": "CHEBI:16236", "name": "EtOH", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_29510", "map_id": "CHEBI:15343", "name": "CH3CHO", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10504254", "map_id": "none", "name": "alcohol dehydrogenase complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10557573", "map_id": "none", "name": "ALDH1B1 tetramer oxidises CH3CHO to CH3COOH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_113539", "map_id": "CHEBI:30089", "name": "CH3COO-", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10557570", "map_id": "none", "name": "ALDH1B1 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q20780", "map_id": "Q20780", "name": "alh-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000107", "map_id": "WBGene00000107", "name": "alh-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9TXM0", "map_id": "Q9TXM0", "name": "alh-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000108", "map_id": "WBGene00000108", "name": "alh-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10556853", "map_id": "none", "name": "ADH5 oxidises S-HMGSH to S-FGSH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5692221", "map_id": "CHEBI:48926", "name": "S-HMGSH", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_5692249", "map_id": "CHEBI:16225", "name": "S-FGSH", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10556850", "map_id": "none", "name": "ADH5:2xZn2+ dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10504267", "map_id": "none", "name": "acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10504264", "map_id": "none", "name": "ALDH2 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "reaction_10504285", "map_id": "none", "name": "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10504282", "map_id": "Q18496", "name": "acs-19", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00007969", "map_id": "WBGene00007969", "name": "acs-19", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10557063", "map_id": "none", "name": "CES1 trimer.CES2 hydrolyse COCN to BEG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_5693702", "map_id": "CHEBI:27958", "name": "COCN", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_5693711", "map_id": "CHEBI:17790", "name": "MeOH", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_5693712", "map_id": "CHEBI:41001", "name": "BEG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10557060", "map_id": "none", "name": "CES1 trimer, CES2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "reaction_10556121", "map_id": "none", "name": "AADAC deacetylates PHEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_5689006", "map_id": "CHEBI:8050", "name": "PHEN", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_5689001", "map_id": "CHEBI:40574", "name": "acetyl group", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_5688995", "map_id": "CHEBI:85505", "name": "4-ethoxyaniline", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10556118", "map_id": "none", "name": "Homologues of AADAC", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q19839", "map_id": "Q19839", "name": "trcs-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009186", "map_id": "WBGene00009186", "name": "trcs-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XWL5", "map_id": "Q9XWL5", "name": "nceh-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012810", "map_id": "WBGene00012810", "name": "nceh-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7JMM5", "map_id": "Q7JMM5", "name": "NCEH1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017515", "map_id": "WBGene00017515", "name": "NCEH1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q94187", "map_id": "Q94187", "name": "NCEH1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10558105", "map_id": "none", "name": "BPHL hydrolyses VACV to ACV", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_6784964", "map_id": "CHEBI:35854", "name": "VACV", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10558102", "map_id": "Q9TZ58", "name": "BPHL", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "false" }, { "id": "WBGene00019280", "map_id": "WBGene00019280", "name": "BPHL", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10556888", "map_id": "none", "name": "ALD3A1 oxidises 4HPCP to CXPA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5692409", "map_id": "CHEBI:196991", "name": "4HPCP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_5692433", "map_id": "CHEBI:3410", "name": "CXPA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10556870", "map_id": "none", "name": "Homologues of ALDH3A1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10568168", "map_id": "none", "name": "MARC1,MARC2 reduce N-hydroxylated compounds", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_8936443", "map_id": "CHEBI:47823", "name": "NOHA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10568165", "map_id": "none", "name": "MARC1:Mo-MPT:MARC2:Mo-MPT:CYB5B:CYB5R3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "true" }, { "id": "CHEBI:21437", "map_id": "CHEBI:21437", "name": "CHEBI:21437", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "U4PC34", "map_id": "U4PC34", "name": "MARC1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018925", "map_id": "WBGene00018925", "name": "MARC1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P91321", "map_id": "P91321", "name": "MARC1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O45394", "map_id": "O45394", "name": "MARC1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10544101", "map_id": "none", "name": "FDXR transfers electrons to FDX1,2 (FDX1L)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10533041", "map_id": "none", "name": "FDX2 (oxidized)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "CHEBI:33737", "map_id": "CHEBI:33737", "name": "CHEBI:33737", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9NA32", "map_id": "Q9NA32", "name": "FDX2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013532", "map_id": "WBGene00013532", "name": "FDX2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10544097", "map_id": "none", "name": "FDXR:FADH2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q9U1X0", "map_id": "Q9U1X0", "name": "FDXR", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013376", "map_id": "WBGene00013376", "name": "FDXR", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10533037", "map_id": "none", "name": "FDX2 (reduced)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "CHEBI:33738", "map_id": "CHEBI:33738", "name": "CHEBI:33738", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10544099", "map_id": "none", "name": "FDXR:FAD", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "reaction_10544103", "map_id": "none", "name": "NADPH transfers electrons to FDXR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "reaction_10533044", "map_id": "none", "name": "FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_379721", "map_id": "CHEBI:35235", "name": "L-Cys", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10533030", "map_id": "none", "name": "2 Iron:FXN:NFS1:ISD11:ISCU", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q9TY03", "map_id": "Q9TY03", "name": "frh-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001486", "map_id": "WBGene00001486", "name": "frh-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O45948", "map_id": "O45948", "name": "iscu-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012885", "map_id": "WBGene00012885", "name": "iscu-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A2R8F5A8", "map_id": "A0A2R8F5A8", "name": "LYRM4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00302998", "map_id": "WBGene00302998", "name": "LYRM4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10533039", "map_id": "none", "name": "FXN:NFS1:ISD11:ISCU:2Fe-2S Cluster", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "reaction_10567878", "map_id": "none", "name": "Formation of 4Fe-4S cluster on ISCA1:ISCA2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10567869", "map_id": "none", "name": "ISCA1:ISCA2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "A5HWB2", "map_id": "A5HWB2", "name": "ISCA1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012666", "map_id": "WBGene00012666", "name": "ISCA1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XVZ9", "map_id": "Q9XVZ9", "name": "ISCA2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013218", "map_id": "WBGene00013218", "name": "ISCA2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10567857", "map_id": "none", "name": "GLRX5:2Fe-2S", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q9XTU9", "map_id": "Q9XTU9", "name": "glrx-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013029", "map_id": "WBGene00013029", "name": "glrx-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10567855", "map_id": "Q9XTU9", "name": "glrx-5", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10567871", "map_id": "none", "name": "ISCA1:ISCA2:4Fe-4S", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "species_10567876", "map_id": "Q21324", "name": "dnj-15", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "WBGene00001033", "map_id": "WBGene00001033", "name": "dnj-15", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10533049", "map_id": "none", "name": "Frataxin binds iron", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10533047", "map_id": "none", "name": "FXN:ISD11:NFS1:ISCU", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "reaction_10554321", "map_id": "none", "name": "SLC2A1 tetramer transports Glc from cytosol to Golgi lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "species_964746", "map_id": "CHEBI:17925", "name": "Glc", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10554318", "map_id": "none", "name": "SLC2A1 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "reaction_10562084", "map_id": "none", "name": "GLYCTK phosphorylates DGA to 3PDGA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_6799497", "map_id": "CHEBI:32398", "name": "DGA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_6799493", "map_id": "CHEBI:58272", "name": "3PDGA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10562081", "map_id": "Q09235", "name": "GLYCTK", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00015733", "map_id": "WBGene00015733", "name": "GLYCTK", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10502888", "map_id": "none", "name": "DAK dimer phosphorylates D-glyceraldehyde to form D-glyceraldehyde 3-phosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_30393", "map_id": "CHEBI:17378", "name": "GA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10502885", "map_id": "none", "name": "TKFC:2Mg2+ dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9N5C4", "map_id": "Q9N5C4", "name": "TKFC", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020962", "map_id": "WBGene00020962", "name": "TKFC", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10502878", "map_id": "none", "name": "ALDOB tetramer cleaves Fru-1-P to GA and DHAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_31221", "map_id": "CHEBI:18105", "name": "Fru 1-P", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10502875", "map_id": "none", "name": "ALDOB tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10554242", "map_id": "none", "name": "AKR1B1 reduces Glc to D-sorbitol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5652213", "map_id": "CHEBI:17924", "name": "D-sorbitol", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10554254", "map_id": "none", "name": "SORD oxidizes D-sorbitol to Fru", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10502896", "map_id": "none", "name": "GALT transfers UMP from UDP-Glc to Gal1P to form UDP-Gal", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_30170", "map_id": "CHEBI:17973", "name": "Gal1P", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10502893", "map_id": "Q27536", "name": "GALT", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00014203", "map_id": "WBGene00014203", "name": "GALT", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10502906", "map_id": "none", "name": "GALE:NAD+ dimer reversibly epimerises UDP-Gal to UDP-Glc", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10502903", "map_id": "none", "name": "GALE:NAD+ dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q564Q1", "map_id": "Q564Q1", "name": "gale-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008132", "map_id": "WBGene00008132", "name": "gale-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10504192", "map_id": "none", "name": "((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)glycogenin => poly{(1,4)-alpha-glucosyl} glycogenin + alpha-D-glucose", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10504148", "map_id": "none", "name": "((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)GYG dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10504189", "map_id": "none", "name": "poly((1,4)-alpha-glucosyl)GYG dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10504153", "map_id": "O62334", "name": "agl-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10526209", "map_id": "none", "name": "PGYM dimer, b form + 2 AMP <=> PGYM b dimer:AMP complex", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10504012", "map_id": "none", "name": "PGYM dimer, b form", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9N5U1", "map_id": "Q9N5U1", "name": "phospho-pygl-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020696", "map_id": "WBGene00020696", "name": "phospho-pygl-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10526195", "map_id": "none", "name": "PGYM b dimer:AMP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10504099", "map_id": "none", "name": "glycogen phosphorylase (PYGM) dimer b + 2 ATP => glycogen phosphorylase (PYGM) dimer a + 2 ADP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10504017", "map_id": "none", "name": "PGYM dimer a form", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10504096", "map_id": "none", "name": "phosphorylase kinase complex (PHKM)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9N3L4", "map_id": "Q9N3L4", "name": "PHKG1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021753", "map_id": "WBGene00021753", "name": "PHKG1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34335", "map_id": "P34335", "name": "PHKA1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00015754", "map_id": "WBGene00015754", "name": "PHKA1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "H2L0I6", "map_id": "H2L0I6", "name": "PHKB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022059", "map_id": "WBGene00022059", "name": "PHKB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10504156", "map_id": "none", "name": "limit dextrin-glycogenin => ((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl) glycogenin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10504128", "map_id": "none", "name": "limit dextrin-glycogenin dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10503904", "map_id": "none", "name": "6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29996", "map_id": "CHEBI:16863", "name": "PDG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_29732", "map_id": "CHEBI:17363", "name": "RU5P", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10503901", "map_id": "none", "name": "PGD dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q17761", "map_id": "Q17761", "name": "PGD", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012015", "map_id": "WBGene00012015", "name": "PGD", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10570503", "map_id": "none", "name": "PGM2:Mg2+ isomerises dR1P to dR5P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_6787326", "map_id": "CHEBI:11563", "name": "dR1P", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_6787328", "map_id": "CHEBI:16132", "name": "dR5P", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10502849", "map_id": "none", "name": "PGM2:Mg2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10569995", "map_id": "none", "name": "RBKS phosphorylates ribose to R5P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_8955853", "map_id": "CHEBI:47013", "name": "D-ribose", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10569992", "map_id": "Q19133", "name": "RBKS", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00008548", "map_id": "WBGene00008548", "name": "RBKS", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10558222", "map_id": "none", "name": "DERA cleaves dR5P to GA3P and CH3CHO", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10558219", "map_id": "Q19264", "name": "DERA", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10558225", "map_id": "none", "name": "PGM2:Mg2+ isomerises R1P to R5P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10503924", "map_id": "none", "name": "RPE dimers isomerise RU5P to XY5P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10503921", "map_id": "none", "name": "RPE:Fe2+ dimers", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q95ZW2", "map_id": "Q95ZW2", "name": "RPE", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017272", "map_id": "WBGene00017272", "name": "RPE", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10506066", "map_id": "none", "name": "D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10506063", "map_id": "none", "name": "PRPS1 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q6AHR3", "map_id": "Q6AHR3", "name": "PRPS1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020107", "map_id": "WBGene00020107", "name": "PRPS1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10508824", "map_id": "none", "name": "D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10512117", "map_id": "none", "name": "ribose 5-phosphate <=> D-ribulose 5-phosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10503929", "map_id": "P41994", "name": "rpia-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00015101", "map_id": "WBGene00015101", "name": "rpia-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10503894", "map_id": "none", "name": "D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10503891", "map_id": "O18229", "name": "PGLS", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00013301", "map_id": "WBGene00013301", "name": "PGLS", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10514364", "map_id": "none", "name": "xylulose 5-phosphate <=> D-ribulose 5-phosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10570173", "map_id": "none", "name": "SHPK phosphorylates Sedo to Sedo7P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_8959707", "map_id": "CHEBI:16802", "name": "Sedo", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10570170", "map_id": "O45814", "name": "shpk-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00012017", "map_id": "WBGene00012017", "name": "shpk-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10503076", "map_id": "none", "name": "D-fructose 1,6-bisphosphate + H2O => D-fructose 6-phosphate + orthophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10503073", "map_id": "none", "name": "FBP tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "G5EBJ7", "map_id": "G5EBJ7", "name": "fbp-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001404", "map_id": "WBGene00001404", "name": "fbp-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10513893", "map_id": "none", "name": "malate + NAD+ <=> oxaloacetate + NADH + H+", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10513890", "map_id": "none", "name": "malate dehydrogenase 1 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9UAV5", "map_id": "Q9UAV5", "name": "mdh-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018491", "map_id": "WBGene00018491", "name": "mdh-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10502823", "map_id": "none", "name": "oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [cytosol]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10502820", "map_id": "none", "name": "Homologues of PCK1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9TYQ8", "map_id": "Q9TYQ8", "name": "pck-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019151", "map_id": "WBGene00019151", "name": "pck-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O02286", "map_id": "O02286", "name": "pck-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011232", "map_id": "WBGene00011232", "name": "pck-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O44906", "map_id": "O44906", "name": "pck-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021043", "map_id": "WBGene00021043", "name": "pck-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10519528", "map_id": "none", "name": "Exchange of alpha-ketoglutarate (2-oxoglutarate) and malate across the inner mitochondrial membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10513880", "map_id": "none", "name": "SLC25A11 homodimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "P90992", "map_id": "P90992", "name": "misc-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00015186", "map_id": "WBGene00015186", "name": "misc-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10513901", "map_id": "none", "name": "Cytosolic glucose 6-phosphate is exchanged for orthophosphate from the endoplasmic reticulum lumen by SLC37A4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_113551", "map_id": "CHEBI:43474", "name": "Pi", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_113782", "map_id": "CHEBI:58225", "name": "G6P", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10513898", "map_id": "C0RSI9", "name": "SLC37A4", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "WBGene00302978", "map_id": "WBGene00302978", "name": "SLC37A4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10518414", "map_id": "none", "name": "oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [mitochondrial matrix]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_372364", "map_id": "CHEBI:58702", "name": "PEP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10518411", "map_id": "O02286", "name": "pck-2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10503122", "map_id": "none", "name": "Pyruvate + CO2 + ATP => ADP + Orthophosphate + Oxaloacetate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10503119", "map_id": "none", "name": "pyruvate carboxylase holoenzyme", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "reaction_10518291", "map_id": "none", "name": "phosphoenolpyruvate [mitochondrial matrix] + citrate [cytosol] => phosphoenolpyruvate [cytosol] + citrate [mitochondrial matrix]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10518422", "map_id": "none", "name": "malate [mitochondrial matrix] + orthophosphate [cytosol] <=> malate [cytosol] + orthophosphate [mitochondrial matrix]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10513883", "map_id": "none", "name": "malate [mitochondrial matrix] + alpha-ketoglutarate [cytosol] <=> malate [cytosol] + alpha-ketoglutarate [mitochondrial matrix]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10571905", "map_id": "none", "name": "FUT3 transfers Fuc to Type 1 chains to form LeA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "species_9605607", "map_id": "CHEBI:140878", "name": "LeA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "reaction_10571890", "map_id": "none", "name": "FUT2 transfers Fuc to LeA to form LeB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "species_9605394", "map_id": "CHEBI:140910", "name": "LeB", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "reaction_10571973", "map_id": "none", "name": "FUT3,5,6,7 transfers Fuc to Type 2 MSGG to form sLeX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "species_9605685", "map_id": "CHEBI:140918", "name": "Type 2 MSGG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_9605661", "map_id": "CHEBI:140916", "name": "sLeX", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10571970", "map_id": "none", "name": "FUT3,5,6,7", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "Q18255", "map_id": "Q18255", "name": "FUT3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10571892", "map_id": "none", "name": "FUT2 transfers Fuc to LeX to form LeY", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "species_9605593", "map_id": "CHEBI:140911", "name": "LeX", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_9605586", "map_id": "CHEBI:140912", "name": "LeY", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "reaction_10571946", "map_id": "none", "name": "B3GALTs transfer Gal to GlcNAc-1,3-Gal-R to form Type 1 chain", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "species_9604808", "map_id": "CHEBI:140876", "name": "GlcNAc-\u03b21,3-Gal-R", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10571943", "map_id": "none", "name": "B3GALTs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "Q95US5", "map_id": "Q95US5", "name": "bre-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10571964", "map_id": "none", "name": "FUT3 transfers Fuc to Type 1 MSGG to form sLeA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "species_9605595", "map_id": "CHEBI:140917", "name": "Type 1 MSGG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_9605615", "map_id": "CHEBI:140914", "name": "sLeA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "reaction_10571903", "map_id": "none", "name": "FUT4,5,9,(10,11) transfer Fuc to Type 2 chains to form LeX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "species_10571900", "map_id": "none", "name": "FUT4,5,9(10,11)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "reaction_10571966", "map_id": "none", "name": "FUT3 transfers Fuc to Type 1 DSGG to form dsLeA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "species_9605649", "map_id": "CHEBI:140919", "name": "Type 1 DSGG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_9605651", "map_id": "CHEBI:140915", "name": "dsLeA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "reaction_10510218", "map_id": "none", "name": "AMP binds to gamma subunit of AMP kinase heterotrimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10510212", "map_id": "none", "name": "AMPK heterotrimer (inactive)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10510216", "map_id": "none", "name": "AMPK heterotrimer:AMP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10517761", "map_id": "none", "name": "Calcium Influx through Voltage-gated Calcium Channels", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10517758", "map_id": "none", "name": "Voltage-gated Calcium Channels (pancreatic beta cell)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "G5EG74", "map_id": "G5EG74", "name": "tag-180", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007041", "map_id": "WBGene00007041", "name": "tag-180", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34374", "map_id": "P34374", "name": "unc-36", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006772", "map_id": "WBGene00006772", "name": "unc-36", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8MQA1", "map_id": "Q8MQA1", "name": "egl-19", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001187", "map_id": "WBGene00001187", "name": "egl-19", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10527093", "map_id": "none", "name": "Transport of Extracellular Glucose to the Cytosol by GLUT1 and GLUT2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_70115", "map_id": "CHEBI:17925", "name": "Glc", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10527090", "map_id": "none", "name": "GLUT1,2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10510248", "map_id": "none", "name": "Transcriptional activation of Acetyl-CoA carboxylase by ChREBP:MLX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10510246", "map_id": "none", "name": "ACC", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10510237", "map_id": "none", "name": "ChREBP:MLX", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "P41846", "map_id": "P41846", "name": "mml-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9TZ70", "map_id": "Q9TZ70", "name": "mxl-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003510", "map_id": "WBGene00003510", "name": "mxl-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10510250", "map_id": "none", "name": "Transcriptional activation of GP-acyl transferase gene by ChREBP:MLX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10507496", "map_id": "none", "name": "Homologues of AGPAT1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10510239", "map_id": "none", "name": "Transcriptional activation of FAS monomer gene by ChREBP:MLX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10568065", "map_id": "none", "name": "PQLC2 transports L-Arg,L-His,L-Lys from lysosomal lumen to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_8932838", "map_id": "none", "name": "L-Arg,L-His,L-Lys", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "true" }, { "id": "species_8932842", "map_id": "none", "name": "L-Arg,L-His,L-Lys", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10568062", "map_id": "Q95XZ6", "name": "laat-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "false" }, { "id": "WBGene00021546", "map_id": "WBGene00021546", "name": "laat-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10551456", "map_id": "none", "name": "NIPAs transport Mg2+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10551447", "map_id": "G4S7C7", "name": "nipa-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "WBGene00021820", "map_id": "WBGene00021820", "name": "nipa-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10551488", "map_id": "none", "name": "CTNS cotransports CySS-, H+ from lysosomal lumen to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5673778", "map_id": "CHEBI:16283", "name": "CySS-", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_379444", "map_id": "CHEBI:16283", "name": "CySS-", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10551485", "map_id": "Q09500", "name": "ctns-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "false" }, { "id": "WBGene00008052", "map_id": "WBGene00008052", "name": "ctns-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10550773", "map_id": "none", "name": "ADD1:ADD3 binds DMTN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10550757", "map_id": "Q95QM5", "name": "unc-115", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00006839", "map_id": "WBGene00006839", "name": "unc-115", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10550769", "map_id": "none", "name": "ADD1:ADD3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10550771", "map_id": "none", "name": "ADD1:ADD3:DMTN", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q95QM5", "map_id": "Q95QM5", "name": "unc-115", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10550761", "map_id": "none", "name": "ADD1:ADD2 binds DMTN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10550752", "map_id": "none", "name": "ADD1:ADD2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10550759", "map_id": "none", "name": "ADD1:ADD2:DMTN", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10551480", "map_id": "none", "name": "MAGT1 transports Mg2+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10551477", "map_id": "P34669", "name": "MAGT1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10551467", "map_id": "none", "name": "TUSC3 transports Mg2+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10551464", "map_id": "P34669", "name": "TUSC3(1-348)", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10509864", "map_id": "none", "name": "Activation of Cdc25C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10509859", "map_id": "Q21762", "name": "phospho-cdc-25.4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10510078", "map_id": "none", "name": "Inactivation of Myt1 kinase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10510073", "map_id": "O18209", "name": "wee-1.3", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00006940", "map_id": "WBGene00006940", "name": "wee-1.3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10510076", "map_id": "O18209", "name": "phospho-wee-1.3", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10555392", "map_id": "none", "name": "CFTR transports Cl- from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10520442", "map_id": "none", "name": "Homologues of CFTR", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10534309", "map_id": "none", "name": "The ABCC family mediates organic anion transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1454930", "map_id": "CHEBI:25696", "name": "organic anion", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_1454919", "map_id": "CHEBI:25696", "name": "organic anion", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10534306", "map_id": "none", "name": "ABCCs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "G5EE72", "map_id": "G5EE72", "name": "mrp-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q3S1M2", "map_id": "Q3S1M2", "name": "mrp-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q20943", "map_id": "Q20943", "name": "mrp-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003408", "map_id": "WBGene00003408", "name": "mrp-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EFP3", "map_id": "G5EFP3", "name": "mrp-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003410", "map_id": "WBGene00003410", "name": "mrp-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9U2G5", "map_id": "Q9U2G5", "name": "mrp-7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003413", "map_id": "WBGene00003413", "name": "mrp-7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q19048", "map_id": "Q19048", "name": "mrp-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003409", "map_id": "WBGene00003409", "name": "mrp-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XW61", "map_id": "Q9XW61", "name": "mrp-8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003414", "map_id": "WBGene00003414", "name": "mrp-8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10566312", "map_id": "none", "name": "VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10566310", "map_id": "none", "name": "Ub-misfolded nascent CFTR:ERAD complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "A3QMC6", "map_id": "A3QMC6", "name": "erl-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016592", "map_id": "WBGene00016592", "name": "erl-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q09463", "map_id": "Q09463", "name": "rnf-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004381", "map_id": "WBGene00004381", "name": "rnf-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10566284", "map_id": "none", "name": "Ub-misfolded nascent CFTR", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10566308", "map_id": "none", "name": "ERAD complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10517776", "map_id": "none", "name": "ABCG5:ABCG8 transports sterols from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_265784", "map_id": "none", "name": "sterols", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:26125", "map_id": "CHEBI:26125", "name": "CHEBI:26125", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_265781", "map_id": "none", "name": "sterols", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10517773", "map_id": "none", "name": "ABCG5:ABCG8", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q18900", "map_id": "Q18900", "name": "abch-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016973", "map_id": "WBGene00016973", "name": "abch-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10520430", "map_id": "none", "name": "PEX-19 docks ABCD1/D2/D3 to peroximal membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane" }, { "id": "species_10520428", "map_id": "none", "name": "PEX19:ABCD1/2/3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10520396", "map_id": "none", "name": "ABCD1-3 dimers", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane", "complex": "true" }, { "id": "reaction_10520399", "map_id": "none", "name": "ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane" }, { "id": "species_382577", "map_id": "CHEBI:15904", "name": "LCFA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_382571", "map_id": "CHEBI:15904", "name": "LCFA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "reaction_10550732", "map_id": "none", "name": "ABCB9 transports peptides from cytosol to lysosomal lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5223341", "map_id": "none", "name": "23mer peptide", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_5223344", "map_id": "none", "name": "23mer peptide", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_10550729", "map_id": "none", "name": "ABCB9 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "reaction_10566317", "map_id": "none", "name": "RNF5 and RNF185 ubiquitinate misfolded CFTR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10566314", "map_id": "none", "name": "misfolded CFTR:ERAD complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10520374", "map_id": "none", "name": "ABC7, mABC1 and mABC2 mediate heme transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane" }, { "id": "species_10520371", "map_id": "none", "name": "Heme transporters", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "G4SRS5", "map_id": "G4SRS5", "name": "abtm-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022281", "map_id": "WBGene00022281", "name": "abtm-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10533110", "map_id": "none", "name": "ABCB6 transports porphyrin from cytosol to mitchondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane" }, { "id": "species_1369066", "map_id": "CHEBI:8337", "name": "porphyrin", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_1369027", "map_id": "CHEBI:8337", "name": "porphyrin", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10533107", "map_id": "none", "name": "MTABC3 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "true" }, { "id": "G5EFD4", "map_id": "G5EFD4", "name": "hmt-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001815", "map_id": "WBGene00001815", "name": "hmt-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10566319", "map_id": "none", "name": "CFTR binds components of the ERAD machinery for ubiquitination and degradation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10566282", "map_id": "none", "name": "Homologues of misfolded CFTR", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10566321", "map_id": "none", "name": "misfolded CFTR is degraded by the 26S proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10534322", "map_id": "none", "name": "ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_1131652", "map_id": "CHEBI:35703", "name": "a xenobiotic", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_1467459", "map_id": "CHEBI:35703", "name": "a xenobiotic", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10534319", "map_id": "none", "name": "ABCA8/B1/B5", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10555389", "map_id": "none", "name": "ABCB4 transports PC from plasma membrane to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_382539", "map_id": "CHEBI:16110", "name": "PC", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10555386", "map_id": "none", "name": "Homologues of ABCB4", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10566333", "map_id": "none", "name": "CFTR transits to the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10520445", "map_id": "none", "name": "HCO3- transport through ion channel", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10550782", "map_id": "none", "name": "ABCF1 binds EIF2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10550778", "map_id": "Q19554", "name": "abcf-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00006512", "map_id": "WBGene00006512", "name": "abcf-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10550780", "map_id": "none", "name": "ABCF1:EIF2S1:EIF2S2:EIF2S3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q19554", "map_id": "Q19554", "name": "abcf-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10518493", "map_id": "none", "name": "Caspase cleavage of DCC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10518490", "map_id": "G5EF96", "name": "unc-40", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10518488", "map_id": "G5EF96", "name": "unc-40", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10556804", "map_id": "none", "name": "SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10556692", "map_id": "Q23500", "name": "aco-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00000040", "map_id": "WBGene00000040", "name": "aco-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10556795", "map_id": "Q23500", "name": "aco-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10556801", "map_id": "none", "name": "SKP1:FBXL5:CUL1:NEDD8", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10535239", "map_id": "none", "name": "Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5691103", "map_id": "CHEBI:78619", "name": "Fe(3+)O(OH)", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10535236", "map_id": "none", "name": "Ferritin Complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10556813", "map_id": "none", "name": "CANDI binds CUL1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10516329", "map_id": "Q17389", "name": "cul-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10556811", "map_id": "none", "name": "CANDI:CUL1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10529202", "map_id": "none", "name": "CYBRD1:Heme reduces Fe3+ to Fe2+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_917828", "map_id": "CHEBI:10545", "name": "e-", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10529199", "map_id": "none", "name": "CYBRD1:Heme", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "O16271", "map_id": "O16271", "name": "CYBRD1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018210", "map_id": "WBGene00018210", "name": "CYBRD1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10556690", "map_id": "none", "name": "ACO1 binds 4Fe-4S", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10556686", "map_id": "Q23500", "name": "aco-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_5690881", "map_id": "none", "name": "4Fe-4S", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10556688", "map_id": "none", "name": "ACO1:4Fe-4S", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q23500", "map_id": "Q23500", "name": "aco-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10556695", "map_id": "none", "name": "ACO1:4Fe-4S isomerises CIT to ISCIT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10556792", "map_id": "none", "name": "FTMT 24mer oxidises 4Fe2+ to 4Fe(3+)O(OH)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_5691135", "map_id": "CHEBI:78619", "name": "Fe(3+)O(OH)", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10556789", "map_id": "none", "name": "FTMT 24mer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "reaction_10529210", "map_id": "none", "name": "SLC40A1:CP:6Cu2+ oxidises Fe2+ to Fe3+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_947586", "compartment_display": "external side of plasma membrane" }, { "id": "reaction_10529213", "map_id": "none", "name": "SLC40A1:HEPH:6Cu2+ oxidises 4Fe2+ to 4Fe3+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_947586", "compartment_display": "external side of plasma membrane" }, { "id": "reaction_10534717", "map_id": "none", "name": "CA1:Zn2+,CA2:Zn2+ hydrate CO2 to HCO3-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10570305", "map_id": "none", "name": "GLUT4 (SLC2A4) tetramer transports Glc from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10570302", "map_id": "none", "name": "GLUT4 / SLC2A4 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10551459", "map_id": "none", "name": "GLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10525428", "map_id": "none", "name": "GLUT1 / SLC2A1 tetramer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10570307", "map_id": "none", "name": "GLUT2 (SLC2A2) tetramer transports Glc from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10512849", "map_id": "none", "name": "GLUT2 / SLC2A2 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10570293", "map_id": "none", "name": "GLUT14 (SLC2A14) tetramer transports Glc from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10570290", "map_id": "none", "name": "GLUT14 / SLC2A14 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10523383", "map_id": "none", "name": "SLC2A9 transports Fru, Glc, urate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_429078", "map_id": "none", "name": "Fru,Glc,urate", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_429148", "map_id": "none", "name": "Fru,Glc,urate", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10523380", "map_id": "none", "name": "Homologues of SLC2A9", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10523335", "map_id": "none", "name": "GLUT7 and GLUT11 transport glucose and fructose", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_428819", "map_id": "none", "name": "hexoses transported by GLUT7/11", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_428802", "map_id": "none", "name": "hexoses transported by GLUT7/11", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10523332", "map_id": "none", "name": "GLUT7/11", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10525432", "map_id": "none", "name": "GLUT1 tetramer binds 4xATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10525430", "map_id": "none", "name": "GLUT1:ATP tetramer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10525434", "map_id": "none", "name": "GLUT1:ATP tetramer dissociates to GLUT1 tetramer and 4xATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10570298", "map_id": "none", "name": "GLUT3 (SLC2A3) tetramer transports Glc from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10570295", "map_id": "none", "name": "GLUT3 / SLC2A3 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10525437", "map_id": "none", "name": "GLUT2 (SLC2A2) transports Glc from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10522496", "map_id": "none", "name": "SLC24A1-4 exchange extracellular 4Na+ for cytosolic Ca2+, K+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10522493", "map_id": "none", "name": "SLC24A1-4", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "G5EC02", "map_id": "G5EC02", "name": "ncx-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003570", "map_id": "WBGene00003570", "name": "ncx-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P90858", "map_id": "P90858", "name": "ncx-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003569", "map_id": "WBGene00003569", "name": "ncx-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10522504", "map_id": "none", "name": "K+-independent Li+/Ca2+ exchanger transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_425815", "map_id": "CHEBI:49713", "name": "Li+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_425810", "map_id": "CHEBI:49713", "name": "Li+", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10522501", "map_id": "P34322", "name": "ncx-7", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10522595", "map_id": "none", "name": "Na+/H+ exchanger transport (at cell membrane)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10522592", "map_id": "none", "name": "SLC9A1-5", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10522518", "map_id": "none", "name": "SLC9A9 exchanges Na+ for H+ across the late endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_172574", "compartment_display": "late endosome membrane" }, { "id": "species_425999", "map_id": "CHEBI:15378", "name": "H+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_173031", "compartment_display": "late endosome lumen", "complex": "false" }, { "id": "species_425977", "map_id": "CHEBI:29101", "name": "Na+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_173031", "compartment_display": "late endosome lumen", "complex": "false" }, { "id": "species_10522515", "map_id": "G5ED88", "name": "nhx-5", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_172574", "compartment_display": "late endosome membrane", "complex": "false" }, { "id": "WBGene00003733", "map_id": "WBGene00003733", "name": "nhx-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10522525", "map_id": "none", "name": "SLC9A6,7 exchange Na+ for H+ across the early endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_171062", "compartment_display": "early endosome membrane" }, { "id": "species_425978", "map_id": "CHEBI:15378", "name": "H+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_171043", "compartment_display": "early endosome lumen", "complex": "false" }, { "id": "species_425971", "map_id": "CHEBI:29101", "name": "Na+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_171043", "compartment_display": "early endosome lumen", "complex": "false" }, { "id": "species_10522520", "map_id": "G5ED88", "name": "nhx-5", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_171062", "compartment_display": "early endosome membrane", "complex": "false" }, { "id": "reaction_10522607", "map_id": "none", "name": "Na+/H+ exchanger transport (at trans-golgi membrane)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_425969", "map_id": "CHEBI:15378", "name": "H+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_425958", "map_id": "CHEBI:29101", "name": "Na+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10522604", "map_id": "none", "name": "SLC9A7/8", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "G5ED88", "map_id": "G5ED88", "name": "nhx-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EBN7", "map_id": "G5EBN7", "name": "nhx-8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003735", "map_id": "WBGene00003735", "name": "nhx-8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10522643", "map_id": "none", "name": "SLC12A3 cotransports Cl-, Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10522640", "map_id": "none", "name": "Homologues of SLC12A3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "H8ESD5", "map_id": "H8ESD5", "name": "nkcc-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012543", "map_id": "WBGene00012543", "name": "nkcc-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34261", "map_id": "P34261", "name": "SLC12A3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00015131", "map_id": "WBGene00015131", "name": "SLC12A3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10522634", "map_id": "none", "name": "SLC12A1,2 cotransports Na+, K+, 2Cl- from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10522631", "map_id": "none", "name": "SLC12A1,2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10522683", "map_id": "none", "name": "SLC12A4,5,6,7 cotransport K+, Cl- from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10522680", "map_id": "none", "name": "SLC12A4,5,6,7", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "S6FWN4", "map_id": "S6FWN4", "name": "kcc-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006504", "map_id": "WBGene00006504", "name": "kcc-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "H2KZC3", "map_id": "H2KZC3", "name": "kcc-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019205", "map_id": "WBGene00019205", "name": "kcc-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q09573", "map_id": "Q09573", "name": "kcc-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019289", "map_id": "WBGene00019289", "name": "kcc-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10523043", "map_id": "none", "name": "SLC17A6,7,8 exchange cytosolic L-Glu for synaptic vesicle H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_201753", "compartment_display": "synaptic vesicle membrane" }, { "id": "species_428548", "map_id": "CHEBI:15378", "name": "H+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_20600", "compartment_display": "synaptic vesicle", "complex": "false" }, { "id": "species_428614", "map_id": "CHEBI:29985", "name": "L-Glu", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_20600", "compartment_display": "synaptic vesicle", "complex": "false" }, { "id": "species_10523040", "map_id": "none", "name": "SLC17A6,7,8", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_201753", "compartment_display": "synaptic vesicle membrane", "complex": "true" }, { "id": "reaction_10523476", "map_id": "none", "name": "Passive I- efflux mediated by SMCT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10567367", "map_id": "none", "name": "SLC25A18,A22 cotransport Glu, H+ from cytosol to mitochondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10567364", "map_id": "none", "name": "SLC25A18,A22", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "Q20847", "map_id": "Q20847", "name": "slc-25a18.2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018901", "map_id": "WBGene00018901", "name": "slc-25a18.2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q93540", "map_id": "Q93540", "name": "slc-25a18.1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008979", "map_id": "WBGene00008979", "name": "slc-25a18.1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10523415", "map_id": "none", "name": "SLC5A5 cotransports Na+ with I- from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10523020", "map_id": "none", "name": "SLC1A1,2,3,6,7 cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_428027", "map_id": "none", "name": "L-Glu,L-Asp,D-Asp", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_427997", "map_id": "none", "name": "L-Glu,L-Asp,D-Asp", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10519220", "map_id": "none", "name": "SLC36A2 cotransports Gly, L-Pro with H+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_375409", "map_id": "none", "name": "Gly, L-Pro", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_375414", "map_id": "none", "name": "Gly, L-Pro", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10519217", "map_id": "none", "name": "Homologues of SLC36A2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10519225", "map_id": "none", "name": "SLC36A1-mediated uptake of glycine, proline, and alanine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_375400", "map_id": "none", "name": "ligands of SLC36A1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_375411", "map_id": "none", "name": "ligands of SLC36A1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10519222", "map_id": "O45936", "name": "slc-36.1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10522933", "map_id": "none", "name": "SLC20A1,2 cotransport Pi, Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10522930", "map_id": "none", "name": "Type III Na+/Pi cotransporters", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "P91840", "map_id": "P91840", "name": "pitr-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012285", "map_id": "WBGene00012285", "name": "pitr-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q17454", "map_id": "Q17454", "name": "pitr-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00015054", "map_id": "WBGene00015054", "name": "pitr-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O17404", "map_id": "O17404", "name": "pitr-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017312", "map_id": "WBGene00017312", "name": "pitr-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q17455", "map_id": "Q17455", "name": "pitr-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00015055", "map_id": "WBGene00015055", "name": "pitr-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O45220", "map_id": "O45220", "name": "pitr-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007141", "map_id": "WBGene00007141", "name": "pitr-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q18697", "map_id": "Q18697", "name": "pitr-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016739", "map_id": "WBGene00016739", "name": "pitr-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10522941", "map_id": "none", "name": "SLC34A3 cotransports Pi, 2Na+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10522938", "map_id": "Q23530", "name": "SLC34A3", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10565621", "map_id": "none", "name": "SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10565618", "map_id": "Q18934", "name": "slc-25a26", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "WBGene00008364", "map_id": "WBGene00008364", "name": "slc-25a26", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10566753", "map_id": "none", "name": "SLC36A4 transports extracellular L-Pro to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_352033", "map_id": "CHEBI:60039", "name": "L-Pro", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10519233", "map_id": "none", "name": "SLC7A2, isoform B (CAT-2B)-mediated uptake of cationic amino acids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_375765", "map_id": "none", "name": "L-Arg, L-Lys, L-Orn", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_375781", "map_id": "none", "name": "L-Arg, L-Lys, L-Orn", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10519230", "map_id": "U4PLX3", "name": "SLC7A2-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "WBGene00013159", "map_id": "WBGene00013159", "name": "SLC7A1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10570181", "map_id": "none", "name": "SLC25A29 transports basic amino acids from cytosol to mitochondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_8959777", "map_id": "none", "name": "SLC25A29 substrates", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:28229", "map_id": "CHEBI:28229", "name": "CHEBI:28229", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:27747", "map_id": "CHEBI:27747", "name": "CHEBI:27747", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_8959775", "map_id": "none", "name": "SLC25A29 substrates", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "species_10570178", "map_id": "Q8I4M0", "name": "slc-25a29", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "WBGene00008320", "map_id": "WBGene00008320", "name": "slc-25a29", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10519238", "map_id": "none", "name": "SLC7A1 (CAT-1)-mediated uptake of cationic amino acids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10519235", "map_id": "U4PLX3", "name": "SLC7A1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10519240", "map_id": "none", "name": "SLC7A2, isoform A (CAT-2A)-mediated uptake of cationic amino acids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10518156", "map_id": "none", "name": "SLC1A5-mediated exchange of alanine and glutamine across the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_212615", "map_id": "CHEBI:58359", "name": "L-Gln", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10518153", "map_id": "none", "name": "Homologues of SLC1A5", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10518133", "map_id": "none", "name": "SLC1A4-mediated exchange of extracellular serine for cytosolic alanine, threonine, or cysteine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_352002", "map_id": "CHEBI:33384", "name": "L-Ser", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_352355", "map_id": "none", "name": "alanine, serine, threonine, or cysteine", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_351990", "map_id": "CHEBI:57926", "name": "L-Thr", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_352359", "map_id": "none", "name": "alanine, serine, threonine, or cysteine", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10518130", "map_id": "none", "name": "Homologues of SLC1A4", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10523018", "map_id": "none", "name": "Proton-coupled di- and tri-peptide cotransport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_428037", "map_id": "none", "name": "Di-peptides/tri-peptides", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "CHEBI:90799", "map_id": "CHEBI:90799", "name": "CHEBI:90799", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:47923", "map_id": "CHEBI:47923", "name": "CHEBI:47923", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_428026", "map_id": "none", "name": "Di-peptides/tri-peptides", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10523015", "map_id": "Q17758", "name": "pept-2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "WBGene00003876", "map_id": "WBGene00003876", "name": "pept-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10523198", "map_id": "none", "name": "Vesicular inhibitory amino acid transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_201753", "compartment_display": "synaptic vesicle membrane" }, { "id": "species_428592", "map_id": "none", "name": "Inhibitory amino acids", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_428632", "map_id": "none", "name": "Inhibitory amino acids", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20600", "compartment_display": "synaptic vesicle", "complex": "true" }, { "id": "species_10523195", "map_id": "P34579", "name": "unc-47", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_201753", "compartment_display": "synaptic vesicle membrane", "complex": "false" }, { "id": "reaction_10565987", "map_id": "none", "name": "ASICs bind STOML3, (STOM)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10565983", "map_id": "none", "name": "STOML3, (STOM)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q20657", "map_id": "Q20657", "name": "sto-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006065", "map_id": "WBGene00006065", "name": "sto-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7YZV6", "map_id": "Q7YZV6", "name": "sto-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006067", "map_id": "WBGene00006067", "name": "sto-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10544954", "map_id": "none", "name": "ASIC trimers:H+", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "G3MU02", "map_id": "G3MU02", "name": "acd-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007775", "map_id": "WBGene00007775", "name": "acd-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EGI5", "map_id": "G5EGI5", "name": "flr-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001465", "map_id": "WBGene00001465", "name": "flr-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10565985", "map_id": "none", "name": "ASIC trimers:H+:STOML3,(STOM)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10544963", "map_id": "none", "name": "ASIC trimers:H+ transport extracellular Na+ to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_2672379", "map_id": "none", "name": "amiloride", "type": "inhibitor", "sub_type": "other", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_2672383", "map_id": "CHEBI:35475", "name": "NSAID", "type": "inhibitor", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10544961", "map_id": "none", "name": "Homologues of ASIC4", "type": "inhibitor", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10545603", "map_id": "none", "name": "TTYH2/3 transport cytosolic Cl- to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10545598", "map_id": "Q20332", "name": "ttyh-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "WBGene00009632", "map_id": "WBGene00009632", "name": "ttyh-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10545477", "map_id": "none", "name": "CLCN4/5/6 exchange Cl- for H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_2731008", "map_id": "CHEBI:17996", "name": "Cl-", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_171907", "compartment_display": "endosome lumen", "complex": "false" }, { "id": "species_10545472", "map_id": "G5EGT4", "name": "clh-5", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "false" }, { "id": "WBGene00000532", "map_id": "WBGene00000532", "name": "clh-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10545608", "map_id": "none", "name": "TTYH1 transports cytosolic Cl- to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10545605", "map_id": "Q20332", "name": "ttyh-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10573259", "map_id": "none", "name": "TRPV1 transports Ca2+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10547087", "map_id": "G5EBV8", "name": "osm-9", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "WBGene00003889", "map_id": "WBGene00003889", "name": "osm-9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10547102", "map_id": "none", "name": "TRPs transport extracellular Ca2+ to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10547099", "map_id": "none", "name": "TRPs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "G5ECM4", "map_id": "G5ECM4", "name": "gtl-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001795", "map_id": "WBGene00001795", "name": "gtl-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34641", "map_id": "P34641", "name": "ced-11", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000425", "map_id": "WBGene00000425", "name": "ced-11", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q20766", "map_id": "Q20766", "name": "gtl-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001796", "map_id": "WBGene00001796", "name": "gtl-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q93971", "map_id": "Q93971", "name": "gon-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001651", "map_id": "WBGene00001651", "name": "gon-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8T666", "map_id": "Q8T666", "name": "cup-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EBV8", "map_id": "G5EBV8", "name": "osm-9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10547119", "map_id": "none", "name": "TRPM4,5 transport extracellular Na+ to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10547116", "map_id": "none", "name": "TRPM4,5", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10572715", "map_id": "none", "name": "ASIC trimers bind H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10545262", "map_id": "none", "name": "SCNN channels", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "P24612", "map_id": "P24612", "name": "mec-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003168", "map_id": "WBGene00003168", "name": "mec-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q21974", "map_id": "Q21974", "name": "unc-8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": 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"none" }, { "id": "WBGene00000950", "map_id": "WBGene00000950", "name": "deg-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q20852", "map_id": "Q20852", "name": "egas-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018906", "map_id": "WBGene00018906", "name": "egas-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_947590", "map_id": "CHEBI:43474", "name": "Pi", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10545415", "map_id": "none", "name": "Ub-SCNN channels", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": 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"sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10545446", "map_id": "X5M5N0", "name": "wnk-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00006941", "map_id": "WBGene00006941", "name": "wnk-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10545550", "map_id": "none", "name": "CLCN7:OSTM1 exchanges Cl- for H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "reaction_10545970", "map_id": "none", "name": "SLC9B1/C2 exchange Na+ for H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10545967", "map_id": "none", "name": "Homologues of SLC9B1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "G5EFS0", "map_id": "G5EFS0", "name": "SLC9B1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009618", "map_id": "WBGene00009618", "name": "SLC9B1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q20273", "map_id": "Q20273", "name": "slc-9b.1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009617", "map_id": "WBGene00009617", "name": "slc-9b.1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XU88", "map_id": "Q9XU88", "name": "slc-9b.2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010214", "map_id": "WBGene00010214", "name": "slc-9b.2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10545907", "map_id": "none", "name": "BESTs transport cytosolic Cl- to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10545904", "map_id": "none", "name": "BESTs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "O17206", "map_id": "O17206", "name": "best-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00015286", "map_id": "WBGene00015286", "name": "best-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q18303", "map_id": "Q18303", "name": "best-7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007808", "map_id": "WBGene00007808", "name": "best-7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O17671", "map_id": "O17671", "name": "best-11", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008186", "map_id": "WBGene00008186", "name": "best-11", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q19978", "map_id": "Q19978", "name": "best-14", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009340", "map_id": "WBGene00009340", "name": "best-14", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O18303", "map_id": "O18303", "name": "best-25", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00014102", "map_id": "WBGene00014102", "name": "best-25", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q21973", "map_id": "Q21973", "name": "best-15", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011258", "map_id": "WBGene00011258", "name": "best-15", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O18304", "map_id": "O18304", "name": "best-26", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00014103", "map_id": "WBGene00014103", "name": "best-26", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q22566", "map_id": "Q22566", "name": "best-17", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020559", "map_id": "WBGene00020559", "name": "best-17", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O45363", "map_id": "O45363", "name": "best-12", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008821", "map_id": "WBGene00008821", "name": "best-12", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q23369", "map_id": "Q23369", "name": "best-22", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013921", "map_id": "WBGene00013921", "name": "best-22", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O45435", "map_id": "O45435", "name": "best-13", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009323", "map_id": "WBGene00009323", "name": "best-13", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7YXH3", "map_id": "Q7YXH3", "name": "best-16", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020046", "map_id": "WBGene00020046", "name": "best-16", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O62095", "map_id": "O62095", "name": "best-8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007988", "map_id": "WBGene00007988", "name": "best-8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q94175", "map_id": "Q94175", "name": "best-9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016613", "map_id": "WBGene00016613", "name": "best-9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34319", "map_id": "P34319", "name": "best-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007404", "map_id": "WBGene00007404", "name": "best-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q965X4", "map_id": "Q965X4", "name": "best-20", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00021368", "map_id": "WBGene00021368", "name": "best-20", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34577", "map_id": "P34577", "name": "best-18", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011868", "map_id": "WBGene00011868", "name": "best-18", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9NA59", "map_id": "Q9NA59", "name": "best-21", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013520", "map_id": "WBGene00013520", "name": "best-21", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A5JYR2", "map_id": "A5JYR2", "name": "best-23", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00014989", "map_id": "WBGene00014989", "name": "best-23", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34672", "map_id": "P34672", "name": "best-24", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022797", "map_id": "WBGene00022797", "name": "best-24", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "J7RNL4", "map_id": "J7RNL4", "name": "BEST1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00220250", "map_id": "WBGene00220250", "name": "BEST1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q17528", "map_id": "Q17528", "name": "best-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007203", "map_id": "WBGene00007203", "name": "best-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O16779", "map_id": "O16779", "name": "best-19", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00206487", "map_id": "WBGene00206487", "name": "best-19", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q17529", "map_id": "Q17529", "name": "best-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007204", "map_id": "WBGene00007204", "name": "best-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O17205", "map_id": "O17205", "name": "best-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00015288", "map_id": "WBGene00015288", "name": "best-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q17851", "map_id": "Q17851", "name": "best-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00015628", "map_id": "WBGene00015628", "name": "best-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10545975", "map_id": "none", "name": "SLC9B2 exchanges Na+, Li+ for H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space" }, { "id": "species_2889081", "map_id": "none", "name": "Na+/Li+", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "true" }, { "id": "species_2889062", "map_id": "none", "name": "Na+/Li+", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "species_10545972", "map_id": "Q20273", "name": "slc-9b.1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "reaction_10545593", "map_id": "none", "name": "CLCN1/2/KA/KB transport cytosolic Cl- to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10545590", "map_id": "none", "name": "CLCN1/2/KA/KB", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9BMK9", "map_id": "Q9BMK9", "name": "clh-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000530", "map_id": "WBGene00000530", "name": "clh-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EG93", "map_id": "G5EG93", "name": "clh-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000529", "map_id": "WBGene00000529", "name": "clh-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "H2L0J1", "map_id": "H2L0J1", "name": "clh-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000531", "map_id": "WBGene00000531", "name": "clh-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q22833", "map_id": "Q22833", "name": "clh-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000528", "map_id": "WBGene00000528", "name": "clh-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10545467", "map_id": "none", "name": "ANOs transport cytosolic Cl- to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10545464", "map_id": "H2L2L3", "name": "anoh-2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10545916", "map_id": "none", "name": "BESTs transport cytosolic HCO3- to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10529392", "map_id": "none", "name": "ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_167012", "map_id": "CHEBI:29108", "name": "Ca2+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10529389", "map_id": "none", "name": "ATP2C1/2:Mg2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "G5EDU1", "map_id": "G5EDU1", "name": "pmr-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004063", "map_id": "WBGene00004063", "name": "pmr-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10523009", "map_id": "none", "name": "ATP2A1-3 transport Ca2+ from cytosol to ER lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_111875", "map_id": "CHEBI:29108", "name": "Ca2+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10522985", "map_id": "G5EEK8", "name": "sca-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10523007", "map_id": "none", "name": "CAMK2 heteromer:CALM:4xCa2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10529571", "map_id": "none", "name": "P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_947588", "map_id": "none", "name": "APLs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_947587", "compartment_display": "cytoplasmic side of plasma membrane", "complex": "true" }, { "id": "species_947594", "map_id": "none", "name": "APLs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_947586", "compartment_display": "external side of plasma membrane", "complex": "true" }, { "id": "species_10529510", "map_id": "none", "name": "P-type ATPases type IV", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "O18182", "map_id": "O18182", "name": "tat-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012360", "map_id": "WBGene00012360", "name": "tat-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7JPE3", "map_id": "Q7JPE3", "name": "tat-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020784", "map_id": "WBGene00020784", "name": "tat-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10556898", "map_id": "none", "name": "ATP13A1 transports Mn2+ from cytosol to ER lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1981162", "map_id": "CHEBI:29035", "name": "Mn2+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10556895", "map_id": "P90747", "name": "catp-8", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "WBGene00007514", "map_id": "WBGene00007514", "name": "catp-8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10556918", "map_id": "none", "name": "ATP13A2 transports cations from cytosol to lysosomal lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5692450", "map_id": "CHEBI:36916", "name": "cation", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_5692484", "map_id": "CHEBI:36916", "name": "cation", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_10556915", "map_id": "none", "name": "Homologues of ATP13A2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "true" }, { "id": "Q9N323", "map_id": "Q9N323", "name": "catp-7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022010", "map_id": "WBGene00022010", "name": "catp-7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q21286", "map_id": "Q21286", "name": "catp-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019493", "map_id": "WBGene00019493", "name": "catp-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q27533", "map_id": "Q27533", "name": "ATP13A2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012341", "map_id": "WBGene00012341", "name": "ATP13A2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10529455", "map_id": "none", "name": "ATP4A/12A:ATP4B exchanges K+ for H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10529452", "map_id": "none", "name": "ATP4A/12A:ATP4B", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "O16331", "map_id": "O16331", "name": "catp-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00015660", "map_id": "WBGene00015660", "name": "catp-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O16436", "map_id": "O16436", "name": "catp-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00015338", "map_id": "WBGene00015338", "name": "catp-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P90735", "map_id": "P90735", "name": "eat-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001137", "map_id": "WBGene00001137", "name": "eat-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EBE7", "map_id": "G5EBE7", "name": "catp-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00013672", "map_id": "WBGene00013672", "name": "catp-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EFV6", "map_id": "G5EFV6", "name": "catp-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00007248", "map_id": "WBGene00007248", "name": "catp-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10565635", "map_id": "none", "name": "VLDLR:PCSK9:Clathrin-coated vesicle translocates from the plasma membrane to lysosomal membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10565625", "map_id": "none", "name": "VLDL:PCSK9:Clathrin:AP2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q04833", "map_id": "Q04833", "name": "lrp-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003071", "map_id": "WBGene00003071", "name": "lrp-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10565633", "map_id": "none", "name": "VLDL:PCSK9:Clathrin:AP2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "reaction_10567491", "map_id": "none", "name": "NPC2 binds CHOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_10567487", "map_id": "O17271", "name": "heh-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_8848047", "map_id": "CHEBI:16113", "name": "CHOL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_10567489", "map_id": "none", "name": "NPC2:CHOL", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "true" }, { "id": "reaction_10511510", "map_id": "none", "name": "LDLR [endosome membrane] => LDLR [plasma membrane]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_74700", "compartment_display": "endosome membrane" }, { "id": "species_10511502", "map_id": "none", "name": "Homologues of LDLR", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "true" }, { "id": "O01768", "map_id": "O01768", "name": "lrp-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003072", "map_id": "WBGene00003072", "name": "lrp-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10511508", "map_id": "none", "name": "Homologues of LDLR", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10567497", "map_id": "none", "name": "NPC2 transfers CHOL to NPC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_10567493", "map_id": "P34389", "name": "ncr-2", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "false" }, { "id": "species_10567495", "map_id": "none", "name": "NPC1:CHOL", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "reaction_10567499", "map_id": "none", "name": "CHOL translocates from lysosome membrane to ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "reaction_10558091", "map_id": "none", "name": "PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_1660541", "compartment_display": "endolysosome membrane" }, { "id": "species_10558057", "map_id": "none", "name": "PCSK9:LDLR:Clathrin:AP2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10558089", "map_id": "none", "name": "PCSK9:LDLR:Clathrin:AP2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_1660541", "compartment_display": "endolysosome membrane", "complex": "true" }, { "id": "reaction_10567546", "map_id": "none", "name": "SOAT1,2 transfer acyl group to CHOL forming CHEST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10567541", "map_id": "Q17498", "name": "mboa-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "WBGene00007174", "map_id": "WBGene00007174", "name": "mboa-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10558093", "map_id": "none", "name": "Degradation of PCSK9:LDLR:Clathrin-coated vesicle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_1660541", "compartment_display": "endolysosome membrane" }, { "id": "species_10558087", "map_id": "none", "name": "Clathrin:AP2 complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_24339", "compartment_display": "clathrin-coated endocytic vesicle membrane", "complex": "true" }, { "id": "reaction_10564126", "map_id": "none", "name": "NCEH1 hydrolyzes cholesterol esters", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10564123", "map_id": "none", "name": "Homologues of NCEH1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10511233", "map_id": "none", "name": "Phosphorylation of Cyclin B1 in the CRS domain", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10511226", "map_id": "none", "name": "CCNB1:p-T161-CDK1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10511126", "map_id": "none", "name": "phospho-cyclin B1(CRS):phosph-Cdc2(Thr 161)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10511230", "map_id": "none", "name": "CRS kinase", "type": "catalyst", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10565795", "map_id": "none", "name": "PP2A methylation by LCMT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10565787", "map_id": "none", "name": "MeL-PP2A", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10565792", "map_id": "P46554", "name": "lcmt-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00007137", "map_id": "WBGene00007137", "name": "lcmt-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10511235", "map_id": "none", "name": "Translocation of CRS phosphorylated Cyclin B1:Cdc2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13231", "compartment_display": "nuclear envelope" }, { "id": "species_10511156", "map_id": "none", "name": "p-4S-CCNB1:p-T161-CDK1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10511269", "map_id": "none", "name": "Dephosphorylation of cytoplasmic Cyclin B1/B2:phospho-Cdc2 (Thr 14, Tyr 15) complexes by CDC25B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10511262", "map_id": "none", "name": "CCNB1,CCNB2:p-T14,Y15,T161-CDK1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10511222", "map_id": "Q21762", "name": "cdc-25.4", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10511239", "map_id": "none", "name": "Translocation of active Cdc25C to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13231", "compartment_display": "nuclear envelope" }, { "id": "species_10511237", "map_id": "Q21762", "name": "phospho-cdc-25.4", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10511175", "map_id": "none", "name": "Myt-1 mediated phosphorylation of Cyclin B:Cdc2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10511168", "map_id": "none", "name": "CCNB:CDK1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10511170", "map_id": "none", "name": "CCNB:p-T14-CDK1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10511172", "map_id": "O18209", "name": "wee-1.3", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10511208", "map_id": "none", "name": "Formation of Cyclin A:Cdc2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10511166", "map_id": "P34556", "name": "cdk-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10511206", "map_id": "none", "name": "CCNA:CDK1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10511177", "map_id": "none", "name": "Formation of Cyclin B:Cdc2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10511164", "map_id": "none", "name": "CCNB", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10565803", "map_id": "none", "name": "PP2A demethylation by PPME1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_8857797", "map_id": "CHEBI:17790", "name": "methanol", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10565800", "map_id": "Q9BIB3", "name": "PPME1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "WBGene00007188", "map_id": "WBGene00007188", "name": "PPME1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10511214", "map_id": "none", "name": "CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10511210", "map_id": "none", "name": "CCNA:p-T14-CDK1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10511212", "map_id": "none", "name": "CCNA:p-T14,T161-CDK1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10511246", "map_id": "none", "name": "Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10511144", "map_id": "none", "name": "CCNB1:p-T14,Y15,T161-CDK1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10511243", "map_id": "none", "name": "CDC25", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10511218", "map_id": "none", "name": "Translocation of Cyclin A:phospho-Cdc2 (Thr 14) to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13231", "compartment_display": "nuclear envelope" }, { "id": "species_10511216", "map_id": "none", "name": "CCNA:p-T14-CDK1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10511252", "map_id": "none", "name": "Dephosphorylation of nuclear Cyclin A:phospho-Cdc2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10511248", "map_id": "none", "name": "CCNA:p-T14,Y15,T161-CDK1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10511250", "map_id": "none", "name": "CCNA:p-T161-CDK1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10511188", "map_id": "none", "name": "Translocation of Cyclin B1:phospho-Cdc2 to the cytoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13231", "compartment_display": "nuclear envelope" }, { "id": "species_10511104", "map_id": "none", "name": "CCNB1:p-T14,Y15,T161-CDK1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10511160", "map_id": "none", "name": "Translocation of Cyclin B1:phospho-Cdc2 complexes to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13231", "compartment_display": "nuclear envelope" }, { "id": "species_10511128", "map_id": "none", "name": "cytoplasmic Cyclin B1:Cdc2 complexes", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10511158", "map_id": "none", "name": "nuclear Cyclin B1:Cdc2 complexes", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10511192", "map_id": "none", "name": "CAK-mediated phosphorylation of Cyclin B1:Cdc2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10511140", "map_id": "none", "name": "CCNB1:p-T14-CDK1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10511181", "map_id": "none", "name": "CCNB1:p-T14,T161-CDK1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10511224", "map_id": "none", "name": "Translocation of Cdc25B to the cytoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13231", "compartment_display": "nuclear envelope" }, { "id": "species_10511220", "map_id": "Q21762", "name": "cdc-25.4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10511258", "map_id": "none", "name": "Translocation of Cdc25 to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13231", "compartment_display": "nuclear envelope" }, { "id": "species_10511256", "map_id": "none", "name": "CDC25", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10546257", "map_id": "none", "name": "Cytosolic PLK1 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10546277", "map_id": "none", "name": "Myosin phosphatase dephosphorylates PLK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10546259", "map_id": "Q9N2L7", "name": "plk-2", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10546274", "map_id": "none", "name": "Phosphorylated Myosin Phosphatase", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10548983", "map_id": "none", "name": "CDK1 phosphorylates BORA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10548981", "map_id": "H2FLK2", "name": "spat-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00010198", "map_id": "WBGene00010198", "name": "spat-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10546195", "map_id": "H2FLK2", "name": "phospho-spat-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10546204", "map_id": "none", "name": "PLK1 phosphorylates BORA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10546197", "map_id": "none", "name": "p-S252-BORA:p-T210-PLK1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "H2FLK2", "map_id": "H2FLK2", "name": "spat-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10546201", "map_id": "H2FLK2", "name": "phospho-spat-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10565466", "map_id": "none", "name": "SCF-FBXL7 ubiquitinates AURKA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10565421", "map_id": "none", "name": "SCF-FBXL7:AURKA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "O01427", "map_id": "O01427", "name": "air-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000099", "map_id": "WBGene00000099", "name": "air-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10565463", "map_id": "none", "name": "SCF-FBXL7:PolyUb-AURKA", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10565468", "map_id": "none", "name": "Proteasome degrades AURKA ubiquitinated by SCF-FBXL7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10565414", "map_id": "none", "name": "SKP1:CUL1:RBX1:FBXL7", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10565423", "map_id": "none", "name": "SCF:FBXL7 binds AURKA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10565419", "map_id": "O01427", "name": "air-2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10565570", "map_id": "none", "name": "TBC1D11 binds RAB6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10565566", "map_id": "H2KZZ6", "name": "tbc-11", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00018075", "map_id": "WBGene00018075", "name": "tbc-11", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10565568", "map_id": "none", "name": "RABGAP1:RAB6:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "H2KZZ6", "map_id": "H2KZZ6", "name": "tbc-11", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10565591", "map_id": "none", "name": "TBC1D25 accelerates GTP hydrolysis by RAB33B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5683628", "compartment_display": "autophagosome membrane" }, { "id": "species_10565586", "map_id": "none", "name": "RAB33:GTP", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "Q20365", "map_id": "Q20365", "name": "rab-33", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004283", "map_id": "WBGene00004283", "name": "rab-33", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10565588", "map_id": "none", "name": "RAB33:GDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "reaction_10565561", "map_id": "none", "name": "TBC1D10A (EPI64) binds ARF6:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_262783", "compartment_display": "recycling endosome membrane" }, { "id": "species_10565550", "map_id": "O44873", "name": "tbc-10", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_19363", "compartment_display": "microvillus", "complex": "false" }, { "id": "species_10565559", "map_id": "none", "name": "TBC1D10A:ARF6:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_262783", "compartment_display": "recycling endosome membrane", "complex": "true" }, { "id": "reaction_10565576", "map_id": "none", "name": "TBC1D15 accelerates GTP hydrolysis by RAB7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane" }, { "id": "species_10565537", "map_id": "none", "name": "RAB7A:GTP", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "species_10565574", "map_id": "none", "name": "RAB7:GDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "reaction_10565547", "map_id": "none", "name": "TBC1D2A accelerates GTP hydrolysis by RAB7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane" }, { "id": "species_10565539", "map_id": "none", "name": "RAB7A:GDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "species_10565545", "map_id": "G5EEB5", "name": "tbc-19", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00007849", "map_id": "WBGene00007849", "name": "tbc-19", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10565498", "map_id": "none", "name": "TBC RabGAPs accelerate GTP hydrolysis by RAB35", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_24339", "compartment_display": "clathrin-coated endocytic vesicle membrane" }, { "id": "species_10565475", "map_id": "none", "name": "RAB35:GTP", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_24339", "compartment_display": "clathrin-coated endocytic vesicle membrane", "complex": "true" }, { "id": "Q9U2C3", "map_id": "Q9U2C3", "name": "rab-35", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004284", "map_id": "WBGene00004284", "name": "rab-35", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10565477", "map_id": "none", "name": "RAB35:GDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_24339", "compartment_display": "clathrin-coated endocytic vesicle membrane", "complex": "true" }, { "id": "species_10565496", "map_id": "none", "name": "RAB35 specific TBC RabGAPs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q20436", "map_id": "Q20436", "name": "tbc-13", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00009726", "map_id": "WBGene00009726", "name": "tbc-13", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "H2KZ54", "map_id": "H2KZ54", "name": "tbc-7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016292", "map_id": "WBGene00016292", "name": "tbc-7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10565533", "map_id": "none", "name": "TBC1D3 associates with RAB5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_171062", "compartment_display": "early endosome membrane" }, { "id": "species_10565501", "map_id": "Q9U2D8", "name": "tbc-17", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_171062", "compartment_display": "early endosome membrane", "complex": "false" }, { "id": "species_10565529", "map_id": "none", "name": "GGA1,2,3:RAB5:GTP:RABGEF1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_171062", "compartment_display": "early endosome membrane", "complex": "true" }, { "id": "A0A486WY48", "map_id": "A0A486WY48", "name": "rabx-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012644", "map_id": "WBGene00012644", "name": "rabx-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10565531", "map_id": "none", "name": "TBC1D3:GGA:RAB5:GTP:RABGEF1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_171062", "compartment_display": "early endosome membrane", "complex": "true" }, { "id": "reaction_10565613", "map_id": "none", "name": "TBC1D14 binds RAB11 and ULK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_262783", "compartment_display": "recycling endosome membrane" }, { "id": "species_10565609", "map_id": "Q21928", "name": "tbc-12", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_261116", "compartment_display": "recycling endosome", "complex": "false" }, { "id": "WBGene00044061", "map_id": "WBGene00044061", "name": "tbc-12", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10565604", "map_id": "Q23023", "name": "unc-51", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_261116", "compartment_display": "recycling endosome", "complex": "false" }, { "id": "species_10565602", "map_id": "O01803", "name": "rab-11.1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_262783", "compartment_display": "recycling endosome membrane", "complex": "false" }, { "id": "species_10565611", "map_id": "none", "name": "TBC1D14:RAB11:ULK1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_262783", "compartment_display": "recycling endosome membrane", "complex": "true" }, { "id": "Q21928", "map_id": "Q21928", "name": "tbc-12", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10554302", "map_id": "none", "name": "POLD,POLE binds deISGylated PCNA after TLS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10554298", "map_id": "none", "name": "PCNA:RPA:RFC:TLS-DNA Template", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10508801", "map_id": "none", "name": "POLD,POLE", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10554300", "map_id": "none", "name": "PCNA:POLD,POLE:RPA:RFC:TLS-DNA Template", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10551331", "map_id": "none", "name": "CLAT:AP1:CLVS bind PI(3,5)P2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane" }, { "id": "species_10551327", "map_id": "none", "name": "CLAT:AP1:CLVS", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane", "complex": "true" }, { "id": "O01755", "map_id": "O01755", "name": "apm-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000150", "map_id": "WBGene00000150", "name": "apm-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O16369", "map_id": "O16369", "name": "aps-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000159", "map_id": "WBGene00000159", "name": "aps-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8WQB3", "map_id": "Q8WQB3", "name": "apg-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000158", "map_id": "WBGene00000158", "name": "apg-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10551329", "map_id": "none", "name": "CLAT:AP1:CLVS:PI(3,5)P2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20592", "compartment_display": "clathrin-coated endocytic vesicle", "complex": "true" }, { "id": "reaction_10524037", "map_id": "none", "name": "trans-Golgi Network Lysosome Vesicle Destined Membrane Coat Assembly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10524031", "map_id": "none", "name": "Lysosome Destined Cargo:AP-1:Arf1-GTP:beta-Arrestin-1:Vamp Complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "species_10522248", "map_id": "P39055", "name": "dyn-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10512231", "map_id": "B1V8A0", "name": "unc-57", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10522246", "map_id": "none", "name": "Clathrin Triskelion", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10517983", "map_id": "none", "name": "Arf1-GDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10524035", "map_id": "none", "name": "Lysosome Destined Cargo:AP-1:Beta-arrestin:Vamp:Clathrin Triskelion:Dynamin:Endophilin Complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "reaction_10524040", "map_id": "none", "name": "trans-Golgi Network Lysosomal Vesicle Scission", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10524001", "map_id": "none", "name": "Lysosome Cargo:AP-1:Beta-arrestin:Clathrin Triskelion:Vamp Complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "reaction_10554828", "map_id": "none", "name": "AP1G2 binds HGS and CHMP2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10554824", "map_id": "Q8WQB3", "name": "apg-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "species_10529030", "map_id": "Q9U2F6", "name": "vps-2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10512214", "map_id": "Q17796", "name": "hgrs-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10554826", "map_id": "none", "name": "AP1G2:HGS:CHMP2A", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "reaction_10518097", "map_id": "none", "name": "Nuclear translocation of catalytic domain of Mst3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13231", "compartment_display": "nuclear envelope" }, { "id": "species_10518081", "map_id": "H2L099", "name": "gck-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00001526", "map_id": "WBGene00001526", "name": "gck-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10518095", "map_id": "H2L099", "name": "gck-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10518085", "map_id": "none", "name": "Caspase-mediated cleavage of MST3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10518079", "map_id": "H2L099", "name": "gck-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10518083", "map_id": "H2L099", "name": "gck-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10515329", "map_id": "none", "name": "Caspase-mediated cleavage of Desmoglein 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10515323", "map_id": "Q19319", "name": "cdh-4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10515327", "map_id": "Q19319", "name": "cdh-4", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10515325", "map_id": "Q19319", "name": "cdh-4", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10514849", "map_id": "none", "name": "Caspase-mediated cleavage of plakophilin-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10514844", "map_id": "Q9U308", "name": "jac-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10514846", "map_id": "Q9U308", "name": "jac-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10518066", "map_id": "none", "name": "Caspase-mediated cleavage of Desmoglein 2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10518062", "map_id": "Q19319", "name": "cdh-4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10518064", "map_id": "Q19319", "name": "cdh-4", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10518052", "map_id": "none", "name": "Caspase-mediated cleavage of Z0-2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10518048", "map_id": "Q8I103", "name": "zoo-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10518050", "map_id": "Q8I103", "name": "zoo-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10514901", "map_id": "none", "name": "Caspase-mediated cleavage of Desmoglein 3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10514895", "map_id": "Q19319", "name": "cdh-4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10514899", "map_id": "Q19319", "name": "cdh-4", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10514897", "map_id": "Q19319", "name": "cdh-4", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10515367", "map_id": "none", "name": "Caspase mediated cleavage of beta-catenin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10515361", "map_id": "none", "name": "beta-catenin", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10515365", "map_id": "O44326", "name": "hmp-2", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10515363", "map_id": "O44326", "name": "hmp-2", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10514919", "map_id": "none", "name": "Caspase-mediated cleavage of Desmoplakin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10514915", "map_id": "A0A1N7SYP3", "name": "vab-10", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10514917", "map_id": "A0A1N7SYP3", "name": "vab-10", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10518089", "map_id": "none", "name": "Caspase-mediated cleavage of TJP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10518087", "map_id": "Q8I103", "name": "zoo-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10518060", "map_id": "none", "name": "Caspase-mediated cleavage of occludin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10518054", "map_id": "Q9N554", "name": "ell-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10518058", "map_id": "Q9N554", "name": "ell-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10518056", "map_id": "Q9N554", "name": "ell-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10514936", "map_id": "none", "name": "Caspase-mediated cleavage of farnesyltransferase/geranyl- geranyltransferase subunit alpha ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10514930", "map_id": "O44501", "name": "fnta-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10514934", "map_id": "O44501", "name": "fnta-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10514932", "map_id": "O44501", "name": "fnta-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10517976", "map_id": "none", "name": "Caspase-mediated cleavage of MASK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10517970", "map_id": "H2L099", "name": "gck-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10517974", "map_id": "H2L099", "name": "gck-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10517972", "map_id": "H2L099", "name": "gck-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10515337", "map_id": "none", "name": "Caspase mediated cleavage of APC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10515331", "map_id": "Q21227", "name": "apr-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10515335", "map_id": "Q21227", "name": "apr-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10515333", "map_id": "Q21227", "name": "apr-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10517161", "map_id": "none", "name": "Caspase 3-mediated cleavage of PKC delta", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10509049", "map_id": "P34722", "name": "tpa-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10517159", "map_id": "P34722", "name": "tpa-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10517157", "map_id": "P34722", "name": "tpa-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10514857", "map_id": "none", "name": "Caspase-mediated cleavage of PKC theta", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10514855", "map_id": "P34722", "name": "tpa-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10514853", "map_id": "P34722", "name": "tpa-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10514890", "map_id": "none", "name": "Caspase-mediated cleavage of Acinus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10514884", "map_id": "P91156", "name": "acin-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00016601", "map_id": "WBGene00016601", "name": "acin-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10514888", "map_id": "P91156", "name": "acin-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10514886", "map_id": "P91156", "name": "acin-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10514879", "map_id": "none", "name": "Caspase-mediated cleavage of Rock-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10514873", "map_id": "P92199", "name": "let-502", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10514877", "map_id": "P92199", "name": "let-502", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10514875", "map_id": "P92199", "name": "let-502", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10518106", "map_id": "none", "name": "Mitochondrial recruitment of Drp1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10518102", "map_id": "Q8WQC9", "name": "drp-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00001093", "map_id": "WBGene00001093", "name": "drp-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10518104", "map_id": "Q8WQC9", "name": "drp-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "false" }, { "id": "species_10518073", "map_id": "G5EBI0", "name": "4D656", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "WBGene00021883", "map_id": "WBGene00021883", "name": "4D656", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10512852", "map_id": "none", "name": "SLC2A2 tetramer transports Fru, Gal, Glc from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_189246", "map_id": "none", "name": "Fru, Gal, Glc", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_188995", "map_id": "CHEBI:17118", "name": "Gal", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_189219", "map_id": "none", "name": "Fru, Gal, Glc", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10512813", "map_id": "none", "name": "SLC2A5 transports fructose from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_189049", "map_id": "CHEBI:15824", "name": "Fru", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10512810", "map_id": "none", "name": "Homologues of SLC2A5", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10554240", "map_id": "none", "name": "RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10554233", "map_id": "none", "name": "RAD18:UBE2B,RBX1:CUL4:DDB1:DTL:PCNA:POLD,POLE:RPA:RFC:Damaged DNA Template", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10554237", "map_id": "none", "name": "MonoUb:K164-PCNA:RPA:RFC:Damaged DNA Template", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10554231", "map_id": "none", "name": "RBX1:CUL4:DDB1:DTL", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10554235", "map_id": "none", "name": "RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10554212", "map_id": "none", "name": "PCNA:POLD,POLE:RPA:RFC:Damaged DNA Template", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10554419", "map_id": "none", "name": "SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10554410", "map_id": "none", "name": "NPLOC4:UFD1L:VCP:SPRTN:POLH:MonoUb:K164-PCNA:RPA:RFC:(TT-CPD:AA-polydNMP)-DNA Template", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q22557", "map_id": "Q22557", "name": "dvc-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00011834", "map_id": "WBGene00011834", "name": "dvc-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EFY1", "map_id": "G5EFY1", "name": "polh-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018721", "map_id": "WBGene00018721", "name": "polh-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q95QZ9", "map_id": "Q95QZ9", "name": "npl-4.2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019121", "map_id": "WBGene00019121", "name": "npl-4.2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q19584", "map_id": "Q19584", "name": "ufd-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006733", "map_id": "WBGene00006733", "name": "ufd-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10508757", "map_id": "G5EFY1", "name": "polh-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10554416", "map_id": "none", "name": "NPLOC4:UFD1L:VPC:SPRTN:MonoUb:K164-PCNA:RPA:RFC:(TT-CPD:AA-polydNMP)-Template DNA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10508774", "map_id": "none", "name": "Insertion of correct bases opposite the lesion by POLH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10508763", "map_id": "none", "name": "POLH:MonoUb:K164-PCNA:RPA:RFC:TT-CPD-DNA Template", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10508771", "map_id": "none", "name": "POLH:MonoUb:K164-PCNA:RPA:RFC:(TT-CPD:AA)-DNA Template", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10508765", "map_id": "none", "name": "POLH binds monoUb:K164-PCNA at damaged TT-CPD-DNA template", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10508761", "map_id": "none", "name": "MonoUb:K164-PCNA:RPA:RFC:TT-CPD-DNA Template", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10508781", "map_id": "none", "name": "Elongation by POLH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10508778", "map_id": "none", "name": "POLH:MonoUb:K164-PCNA:RPA:RFC:(TT-CPD:AA-polydNMP)-DNA Template", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10554412", "map_id": "none", "name": "SPRTN recruits VCP to monoUb:K164-PCNA associated with POLH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10554408", "map_id": "none", "name": "NPLOC4:UFD1L:VCP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10554392", "map_id": "none", "name": "SPRTN:POLH:MonoUb:K164-PCNA:RPA:RFC:(TT-CPD:AA-polydNMP)-DNA Template", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10554414", "map_id": "none", "name": "SPRTN binds monoUb:K164-PCNA associated with POLH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10554390", "map_id": "Q22557", "name": "dvc-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10556021", "map_id": "none", "name": "FEN1 cleaves displaced ssDNA flaps during MMEJ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10556014", "map_id": "none", "name": "Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8:FEN1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_68454", "map_id": "none", "name": "Flap", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10556018", "map_id": "none", "name": "Extended microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10556008", "map_id": "none", "name": "MRN and RBBP8 resect DNA DSBs in MMEJ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10556001", "map_id": "none", "name": "DNA DSB:MRN:RBBP8", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10556005", "map_id": "none", "name": "Microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10519896", "map_id": "none", "name": "5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_380598", "map_id": "CHEBI:50157", "name": "HIALD", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_380593", "map_id": "CHEBI:27823", "name": "HIAA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10524588", "map_id": "none", "name": "SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10524585", "map_id": "Q9N3C7", "name": "mod-5", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "WBGene00003387", "map_id": "WBGene00003387", "name": "mod-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10517995", "map_id": "none", "name": "trans-Golgi Network Coat Activation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10517987", "map_id": "none", "name": "Arf1-GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "reaction_10522258", "map_id": "none", "name": "trans-Golgi Network Coat Assembly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10522240", "map_id": "none", "name": "Cargo:AP-1:Arf1-GTP:beta-Arrestin-1:Vamp Complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "species_10522256", "map_id": "none", "name": "Cargo:AP-1:Beta-arrestin:Vamp:Clathrin Triskelion:Dynamin:Endophilin Complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "reaction_10522389", "map_id": "none", "name": "trans-Golgi Network Vesicle Scission", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10522386", "map_id": "none", "name": "Cargo:AP-1:Beta-arrestin:Clathrin Triskelion:Vamp Complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_437051", "compartment_display": "cytoplasmic vesicle membrane", "complex": "true" }, { "id": "reaction_10566464", "map_id": "none", "name": "CLASP proteins and cargo are recruited to the nascent clathrin-coated pit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10566399", "map_id": "none", "name": "CLASP proteins:cargo", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10566401", "map_id": "none", "name": "PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10567111", "map_id": "none", "name": "Dissociation of AAK1 and dephosphorylation of AP-2 mu2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_24339", "compartment_display": "clathrin-coated endocytic vesicle membrane" }, { "id": "species_10567109", "map_id": "none", "name": "PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_24339", "compartment_display": "clathrin-coated endocytic vesicle membrane", "complex": "true" }, { "id": "Q9GYH7", "map_id": "Q9GYH7", "name": "rme-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004377", "map_id": "WBGene00004377", "name": "rme-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q02328", "map_id": "Q02328", "name": "hipr-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00022717", "map_id": "WBGene00022717", "name": "hipr-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A486WXP9", "map_id": "A0A486WXP9", "name": "dnj-25", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001043", "map_id": "WBGene00001043", "name": "dnj-25", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q6AHQ8", "map_id": "Q6AHQ8", "name": "sdpn-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018467", "map_id": "WBGene00018467", "name": "sdpn-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8I4E2", "map_id": "Q8I4E2", "name": "lst-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00003086", "map_id": "WBGene00003086", "name": "lst-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10566724", "map_id": "none", "name": "PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_24339", "compartment_display": "clathrin-coated endocytic vesicle membrane", "complex": "true" }, { "id": "species_10565728", "map_id": "none", "name": "Homologues of AAK1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10565769", "map_id": "none", "name": "Recruitment of AP-2 complex and clathrin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10565757", "map_id": "Q9N489", "name": "ncap-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10565755", "map_id": "none", "name": "PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10565761", "map_id": "none", "name": "PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10565767", "map_id": "none", "name": "ARFGAP1:ARF6:GTP", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10567113", "map_id": "none", "name": "RAB5 and GAPVD1 bind AP-2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_24339", "compartment_display": "clathrin-coated endocytic vesicle membrane" }, { "id": "species_10566661", "map_id": "none", "name": "PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_24339", "compartment_display": "clathrin-coated endocytic vesicle membrane", "complex": "true" }, { "id": "species_10567107", "map_id": "none", "name": "GGC-RAB5:GDP:GAPVD1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_24339", "compartment_display": "clathrin-coated endocytic vesicle membrane", "complex": "true" }, { "id": "reaction_10567115", "map_id": "none", "name": "Initial binding of AP-2 and clathrin to PI(4,5)P2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10565751", "map_id": "none", "name": "PI(4,5)P2:AP-2:clathrin", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10566475", "map_id": "none", "name": "PIP5K1C phosphorylates PI(4)P to PI(4,5)P2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10521254", "map_id": "O01759", "name": "ppk-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10566666", "map_id": "none", "name": "HSPA8-mediated ATP hydrolysis promotes vesicle uncoating", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_24339", "compartment_display": "clathrin-coated endocytic vesicle membrane" }, { "id": "species_10566659", "map_id": "none", "name": "PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_24339", "compartment_display": "clathrin-coated endocytic vesicle membrane", "complex": "true" }, { "id": "species_10566663", "map_id": "none", "name": "clathrin:HSPA8:ADP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10566477", "map_id": "none", "name": "Clathrin recruits PIK3C2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10537176", "map_id": "G5EDY0", "name": "piki-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10566403", "map_id": "none", "name": "PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10566508", "map_id": "none", "name": "BAR domain proteins recruit dynamin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10566504", "map_id": "none", "name": "DNM:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10566502", "map_id": "none", "name": "PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10566506", "map_id": "none", "name": "PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10566480", "map_id": "none", "name": "Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10566672", "map_id": "none", "name": "Clathrin recruits auxilins to the clathrin-coated vesicle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_24339", "compartment_display": "clathrin-coated endocytic vesicle membrane" }, { "id": "species_10566668", "map_id": "none", "name": "PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_24339", "compartment_display": "clathrin-coated endocytic vesicle membrane", "complex": "true" }, { "id": "species_10522393", "map_id": "A0A486WXP9", "name": "dnj-25", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10566670", "map_id": "none", "name": "PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_24339", "compartment_display": "clathrin-coated endocytic vesicle membrane", "complex": "true" }, { "id": "reaction_10566674", "map_id": "none", "name": "Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_24339", "compartment_display": "clathrin-coated endocytic vesicle membrane" }, { "id": "species_10551064", "map_id": "none", "name": "HSPA8:ATP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10566677", "map_id": "none", "name": "Dynamin-mediated GTP hydrolysis promotes vesicle scission", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10566520", "map_id": "none", "name": "PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10565780", "map_id": "none", "name": "AAK1 phosphorylates AP-2 mu subunit at T156", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10566523", "map_id": "none", "name": "SYNJ hydrolyze PI(4,5)P2 to PI(4)P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10566518", "map_id": "none", "name": "PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10566525", "map_id": "none", "name": "Endophilins recruit synaptojanins to the clathrin-coated pit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10566462", "map_id": "none", "name": "F- and N- BAR domain proteins bind the clathrin-coated pit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10566428", "map_id": "Q8I4E2", "name": "lst-4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10566426", "map_id": "none", "name": "PACSIN dimers", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10566456", "map_id": "none", "name": "TRIP10 dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10566409", "map_id": "none", "name": "AMPH:BIN1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10566437", "map_id": "none", "name": "FNBP1 dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10512243", "map_id": "none", "name": "SH3GLs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10566448", "map_id": "none", "name": "FNBP1L dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10565743", "map_id": "none", "name": "FCHO1,2 dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10566460", "map_id": "none", "name": "PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10552405", "map_id": "none", "name": "LTCC multimer transports Ca2+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10552402", "map_id": "none", "name": "LTCC multimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10552761", "map_id": "none", "name": "PRKACA phosphorylates TNNI3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10552741", "map_id": "none", "name": "Homologues of TNNI3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9XUN9", "map_id": "Q9XUN9", "name": "phospho-tni-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006585", "map_id": "WBGene00006585", "name": "phospho-tni-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O44572", "map_id": "O44572", "name": "phospho-tni-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006586", "map_id": "WBGene00006586", "name": "phospho-tni-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q20334", "map_id": "Q20334", "name": "phospho-tni-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006584", "map_id": "WBGene00006584", "name": "phospho-tni-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9GYF1", "map_id": "Q9GYF1", "name": "phospho-unc-27", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006764", "map_id": "WBGene00006764", "name": "phospho-unc-27", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10552759", "map_id": "none", "name": "Homologues of p-S23,S24-TNNI3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10524944", "map_id": "none", "name": "Myosin Binds ATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10524942", "map_id": "none", "name": "Calcium Bound Myosin Actin Complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q8I7M7", "map_id": "Q8I7M7", "name": "tmd-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006582", "map_id": "WBGene00006582", "name": "tmd-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O01479", "map_id": "O01479", "name": "unc-94", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006823", "map_id": "WBGene00006823", "name": "unc-94", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q22866", "map_id": "Q22866", "name": "lev-11", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00002978", "map_id": "WBGene00002978", "name": "lev-11", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "G5EC32", "map_id": "G5EC32", "name": "sorb-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00012891", "map_id": "WBGene00012891", "name": "sorb-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10524933", "map_id": "none", "name": "ATP:Calcium Bound Myosin Actin Complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10524948", "map_id": "none", "name": "Calcium Binds Caldesmon", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10524946", "map_id": "none", "name": "Inactive Myosin Actin Contractile Complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10524950", "map_id": "none", "name": "Release Of ADP From Myosin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10524937", "map_id": "none", "name": "ADP:Calcium Bound Myosin Actin Complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10524940", "map_id": "none", "name": "ATP Hydrolysis By Myosin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10524866", "map_id": "none", "name": "ATP Bound Smooth Muscle Myosin Complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10551263", "map_id": "none", "name": "DYSF, CAV3 and TRIM72 bind", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_437051", "compartment_display": "cytoplasmic vesicle membrane" }, { "id": "species_10551259", "map_id": "Q9N3T6", "name": "TRIM72", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_437051", "compartment_display": "cytoplasmic vesicle membrane", "complex": "false" }, { "id": "species_10551257", "map_id": "Q17388", "name": "fer-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_437051", "compartment_display": "cytoplasmic vesicle membrane", "complex": "false" }, { "id": "WBGene00001414", "map_id": "WBGene00001414", "name": "fer-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10551252", "map_id": "Q18879", "name": "cav-2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10551261", "map_id": "none", "name": "CAV3:TRIM72:DYSF", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q17388", "map_id": "Q17388", "name": "fer-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10517408", "map_id": "none", "name": "Integrin alpha7beta1 binds Laminin-211, 221, 411, 512, 521", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10517404", "map_id": "none", "name": "Laminin-211, 221, 411, 512, 521", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10517402", "map_id": "none", "name": "Integrin alpha7beta1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10517406", "map_id": "none", "name": "Integrin alpha7beta1:Laminin-211, 221, 411, 512, 521", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10517382", "map_id": "none", "name": "Integrins alpha3beta1, alpha6beta4 bind laminin-332, 511, 521, (211, 221)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10517378", "map_id": "none", "name": "Laminins-332, 511, 521, (211, 221)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10517313", "map_id": "none", "name": "Integrin alpha3beta1, alpha6beta4", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10517380", "map_id": "none", "name": "Integrin alpha3beta1, alpha6beta4:Laminins-332, 511, 521, (211, 221)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10548376", "map_id": "none", "name": "Integrin alpha6beta1 binds laminin-322, 512, 521, 211, 221, 411", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10548372", "map_id": "none", "name": "Laminin-211, 221, 332, 411, 512, 521", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10548370", "map_id": "none", "name": "Integrin alpha6beta1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10548374", "map_id": "none", "name": "Integrin alpha6beta1:Laminin-211, 221, 332, 411, 512, 521", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10517896", "map_id": "none", "name": "Integrin alpha2beta1 binds laminin-332", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10517892", "map_id": "none", "name": "Integrin alpha2beta1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10517894", "map_id": "none", "name": "Integrin alpha2beta1:Laminin-332", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10548927", "map_id": "none", "name": "Laminin-111 binds endostatin dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10548923", "map_id": "none", "name": "Endostatin dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10544249", "map_id": "none", "name": "Laminin-111", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10548925", "map_id": "none", "name": "Laminin-111:Endostatin dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10572433", "map_id": "none", "name": "RRAGC,D exchanges GTP for GDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane" }, { "id": "species_10572426", "map_id": "none", "name": "v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GTP", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "species_10572430", "map_id": "none", "name": "v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "reaction_10572545", "map_id": "none", "name": "v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane" }, { "id": "species_10572439", "map_id": "none", "name": "v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "species_10572450", "map_id": "none", "name": "v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "reaction_10572448", "map_id": "none", "name": "v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane" }, { "id": "species_10572435", "map_id": "none", "name": "SLC38A9:L-Arg", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "species_10572437", "map_id": "none", "name": "v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP:SLC38A9:Arg", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "reaction_10572553", "map_id": "none", "name": "mTORC1 binds RHEB:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane" }, { "id": "species_10572452", "map_id": "none", "name": "v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1:RHEB:GTP", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "reaction_10572457", "map_id": "none", "name": "RRAGA,B hydrolyzes GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane" }, { "id": "species_10572454", "map_id": "none", "name": "v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP:mTORC1:RHEB:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "reaction_10572444", "map_id": "none", "name": "RRAGA,B exchanges GDP for GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane" }, { "id": "species_10572441", "map_id": "none", "name": "v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arg", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "reaction_10572542", "map_id": "none", "name": "RRAGC,D hydrolyzes GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane" }, { "id": "species_10572540", "map_id": "none", "name": "FLCN:FNIP1,2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "S6FMZ4", "map_id": "S6FMZ4", "name": "flcn-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017699", "map_id": "WBGene00017699", "name": "flcn-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "H2L0I8", "map_id": "H2L0I8", "name": "fnip-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00020208", "map_id": "WBGene00020208", "name": "fnip-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10572446", "map_id": "none", "name": "v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane" }, { "id": "reaction_10557938", "map_id": "none", "name": "Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10557934", "map_id": "none", "name": "TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q21302", "map_id": "Q21302", "name": "xpa-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00006963", "map_id": "WBGene00006963", "name": "xpa-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10508627", "map_id": "none", "name": "ERCC1:ERCC4", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "G5EBZ1", "map_id": "G5EBZ1", "name": "xpf-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008140", "map_id": "WBGene00008140", "name": "xpf-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q93456", "map_id": "Q93456", "name": "ercc-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008665", "map_id": "WBGene00008665", "name": "ercc-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10557936", "map_id": "none", "name": "TC-NER incision complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10573109", "map_id": "none", "name": "ERCC3-facilitated RNA Pol II backtracking in TC-NER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10557921", "map_id": "none", "name": "TC-NER pre-incision complex:Partially open bubble damaged DNA template:trimmed nascent mRNA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10557932", "map_id": "none", "name": "TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10557924", "map_id": "none", "name": "ERCC2-facilitated RNA Pol II backtracking in TC-NER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10557910", "map_id": "none", "name": "TC-NER pre-incision complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10557943", "map_id": "none", "name": "5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10557940", "map_id": "none", "name": "TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA ", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10557958", "map_id": "none", "name": "DNA polymerases delta, epsilon or kappa bind the TC-NER site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10557954", "map_id": "none", "name": "PCNA homotrimer,MonoUb:K164-PCNA homotrimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10557952", "map_id": "none", "name": "POLD,POLE,POLK", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10557956", "map_id": "none", "name": "TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10553056", "map_id": "none", "name": "FKBP5 binds HSP90:ATP:STIP1:HSP70:nascent protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10553038", "map_id": "none", "name": "HSP90:ATP:STIP1:HSP70:nascent protein", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "O16259", "map_id": "O16259", "name": "sti-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00019983", "map_id": "WBGene00019983", "name": "sti-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10552844", "map_id": "O45418", "name": "fkb-6", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10553046", "map_id": "none", "name": "HSP90:ATP:FKBP5:STIP1:HSP70:nascent protein", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10573120", "map_id": "none", "name": "SH binds NR3C1 (in HSP90:ATP:FKBP4:PTGES3:NR3C1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10552862", "map_id": "none", "name": "HSP90:ATP:FKBP4:PTGES3:NR3C1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_5618094", "map_id": "none", "name": "SH", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10552864", "map_id": "none", "name": "HSP90:ATP:FKBP4:PTGES3:NR3C1:SH", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10573086", "map_id": "none", "name": "HSP90:ATP:FKBP4:PTGES3:NR3C1:NR3C1 agonists", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10573088", "map_id": "none", "name": "NR3C1 binds NR3C1 agonists", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9678859", "map_id": "none", "name": "NR3C1 agonists", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10547715", "map_id": "none", "name": "HSP70 binds to HSP40:nascent protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10547711", "map_id": "none", "name": "HSP40:nascent protein", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "O45502", "map_id": "O45502", "name": "dnj-12", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001030", "map_id": "WBGene00001030", "name": "dnj-12", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O16303", "map_id": "O16303", "name": "dnj-19", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00001037", "map_id": "WBGene00001037", "name": "dnj-19", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10547713", "map_id": "none", "name": "HSP70:ATP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10547586", "map_id": "none", "name": "HSP40:HSP70:ATP:nascent protein", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10553058", "map_id": "none", "name": "ATP binding to HSP90 triggers conformation change", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10547658", "map_id": "none", "name": "HSP90:STIP1:HSP70:nascent protein", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10553060", "map_id": "none", "name": "p23 (PTGES3) binds HSP90:ATP:FKBP4:nascent protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10553040", "map_id": "none", "name": "HSP90:ATP:FKBP4:STIP1:HSP70:nascent protein", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10547646", "map_id": "O16259", "name": "sti-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10552852", "map_id": "none", "name": "HSP90:ATP:FKBP4:PTGES3:nascent protein:", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10547591", "map_id": "none", "name": "ATP hydrolysis by HSP70", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10547588", "map_id": "none", "name": "HSP40:HSP70:ADP:nascent protein", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10547584", "map_id": "none", "name": "HSP40s", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10553035", "map_id": "none", "name": "HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10552858", "map_id": "none", "name": "HSP90:ATP:FKBP4:PTGES3:SHR:SH", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10552874", "map_id": "none", "name": "HSP90:ATP:PTGES3:FKBP52:NR3C1:SH", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10552868", "map_id": "none", "name": "HSP90:ATP:PTGES3:FKBP52:SHR:SH", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10547660", "map_id": "none", "name": "STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10573294", "map_id": "none", "name": "Androgens binds AR (in the HSP90 chaperone complex)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_8979218", "map_id": "none", "name": "Androgens", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10573288", "map_id": "none", "name": "HSP90:ATP:FKBP4:PTGES3:AR", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10573292", "map_id": "none", "name": "HSP90:ATP:FKBP4:PTGES3:AR:Androgens", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10553042", "map_id": "none", "name": "FKBP4 binds HSP90:ATP:STIP1:HSP70:nascent protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10552850", "map_id": "O45418", "name": "fkb-6", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10552854", "map_id": "none", "name": "FKBP4 replaces FKBP5 within HSP90:ATP:FKBP5:unfolded protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10552848", "map_id": "none", "name": "HSP90:ATP:FKBP5:PTGES3:nascent protein:", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10553048", "map_id": "none", "name": "p23 (PTGES3) binds HSP90:ATP:FKBP5:nascent protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10553054", "map_id": "none", "name": "SH binds SHR within the HSP90 chaperone complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10553052", "map_id": "none", "name": "HSP90:ATP:FKBP4:PTGES3:SHR", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10532184", "map_id": "none", "name": "HIF-alpha translocates from cytosol to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10532172", "map_id": "G5EGD2", "name": "hif-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10532178", "map_id": "G5EGD2", "name": "hif-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10532232", "map_id": "none", "name": "Formation of HIF:CBP:p300 complex at promoters", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10532221", "map_id": "none", "name": "HIF", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10532230", "map_id": "none", "name": "HIF:CBP:p300", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10532250", "map_id": "none", "name": "HIF-alpha binds ARNT (HIF1-beta) forming HIF-alpha:ARNT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10518832", "map_id": "none", "name": "Noradrenaline clearance from the synaptic cleft", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "reaction_10572361", "map_id": "none", "name": "ACHEIs bind ACHE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10518366", "map_id": "none", "name": "Homologues of ACHE", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_9634838", "map_id": "none", "name": "ACHEIs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10567745", "map_id": "none", "name": "DENND5A,B exchange GTP for GDP on RAB39", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10567729", "map_id": "none", "name": "GGC-RAB39:GDP:GDIs,CHMs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q18969", "map_id": "Q18969", "name": "rab-39", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004286", "map_id": "WBGene00004286", "name": "rab-39", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10567735", "map_id": "none", "name": "GGC-RAB39:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "species_10567253", "map_id": "none", "name": "GDIs,CHMs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10567740", "map_id": "Q18780", "name": "lst-6", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00016889", "map_id": "WBGene00016889", "name": "lst-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10567680", "map_id": "none", "name": "TRAPPC complexes exchange GTP for GDP on RAB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13946", "compartment_display": "transport vesicle membrane" }, { "id": "species_10567646", "map_id": "none", "name": "GGC-RAB1:GDP:GDIs,CHMs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10567656", "map_id": "none", "name": "GGC-RAB1:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_13946", "compartment_display": "transport vesicle membrane", "complex": "true" }, { "id": "species_10567677", "map_id": "none", "name": "TRAPPCs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q5WRR4", "map_id": "Q5WRR4", "name": "trpp-12", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016614", "map_id": "WBGene00016614", "name": "trpp-12", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q95QQ2", "map_id": "Q95QQ2", "name": "TRAPPC13", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00016964", "map_id": "WBGene00016964", "name": "TRAPPC13", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9BI63", "map_id": "Q9BI63", "name": "trpp-8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018512", "map_id": "WBGene00018512", "name": "trpp-8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10567296", "map_id": "none", "name": "RAB5 GEFs exchange GTP for GDP on RAB5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_171062", "compartment_display": "early endosome membrane" }, { "id": "species_10567270", "map_id": "none", "name": "GGC-RAB5:GDP:GDIs,CHMs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10567278", "map_id": "none", "name": "GGC-RAB5:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_171062", "compartment_display": "early endosome membrane", "complex": "true" }, { "id": "species_10567293", "map_id": "none", "name": "RAB5 GEFs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "G5ECF0", "map_id": "G5ECF0", "name": "rin-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00008183", "map_id": "WBGene00008183", "name": "rin-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10567266", "map_id": "none", "name": "RAB3 GEFs exchange GTP for GDP on RAB3A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_216813", "compartment_display": "secretory granule membrane" }, { "id": "species_10567255", "map_id": "none", "name": "GGC-RAB3A:GDP:GDIs,CHMs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10567259", "map_id": "none", "name": "GGC-RAB3A:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_216813", "compartment_display": "secretory granule membrane", "complex": "true" }, { "id": "species_10567263", "map_id": "none", "name": "RAB3 GEFs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "O02626", "map_id": "O02626", "name": "aex-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00000086", "map_id": "WBGene00000086", "name": "aex-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10567429", "map_id": "none", "name": "RAB8 GEFs exchange GTP for GDP on RAB8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane" }, { "id": "species_10567407", "map_id": "none", "name": "GGC-RAB8:GDP:GDIs,CHMs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10567419", "map_id": "none", "name": "GGC-RAB8:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane", "complex": "true" }, { "id": "species_10567426", "map_id": "none", "name": "RAB8 GEFs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10567401", "map_id": "none", "name": "DENND4s exchange GTP for GDP on RAB10", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_437051", "compartment_display": "cytoplasmic vesicle membrane" }, { "id": "species_10567385", "map_id": "none", "name": "GGC-RAB10:GDP:GDIs,CHMs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10567389", "map_id": "none", "name": "GGC-RAB10:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_437051", "compartment_display": "cytoplasmic vesicle membrane", "complex": "true" }, { "id": "species_10567394", "map_id": "U4PBM1", "name": "denn-4", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00018681", "map_id": "WBGene00018681", "name": "denn-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10567468", "map_id": "none", "name": "p-ULK1 phosphorylates DENND3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10567461", "map_id": "U4PBM1", "name": "denn-4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10567465", "map_id": "U4PBM1", "name": "phospho-denn-4", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10554852", "map_id": "Q23023", "name": "phospho-unc-51", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10568111", "map_id": "none", "name": "Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10567690", "map_id": "Q7K7A5", "name": "rme-4", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00004375", "map_id": "WBGene00004375", "name": "rme-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10568106", "map_id": "Q7K7A5", "name": "phospho-rme-4", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10567695", "map_id": "none", "name": "DENND1s exchange GTP for GDP on RAB35", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_262783", "compartment_display": "recycling endosome membrane" }, { "id": "species_10567684", "map_id": "none", "name": "GGC-RAB35:GDP:GDIs,CHMs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10567688", "map_id": "none", "name": "GGC-RAB35:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_262783", "compartment_display": "recycling endosome membrane", "complex": "true" }, { "id": "reaction_10567569", "map_id": "none", "name": "RAB21 GEFs exchange GTP for GDP on RAB21", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_171062", "compartment_display": "early endosome membrane" }, { "id": "species_10567558", "map_id": "none", "name": "GGC-RAB21:GDP:GDIs,CHMs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q22045", "map_id": "Q22045", "name": "rab-21", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004279", "map_id": "WBGene00004279", "name": "rab-21", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10567562", "map_id": "none", "name": "GGC-RAB21:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_171062", "compartment_display": "early endosome membrane", "complex": "true" }, { "id": "species_10567564", "map_id": "Q9TXP3", "name": "mtm-5", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10567536", "map_id": "none", "name": "DENND6A,B exchange GTP for GDP on RAB14", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10567520", "map_id": "none", "name": "GGC-RAB14:GDP:GDIs,CHMs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10567524", "map_id": "none", "name": "GGC-RAB14:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_262783", "compartment_display": "recycling endosome membrane", "complex": "true" }, { "id": "species_10567533", "map_id": "none", "name": "DENND6A,B", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "O45074", "map_id": "O45074", "name": "DENND6A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018777", "map_id": "WBGene00018777", "name": "DENND6A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10567638", "map_id": "none", "name": "MON1:CCZ1 exchanges GTP for GDP on RAB7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane" }, { "id": "species_10567615", "map_id": "none", "name": "GGC-RAB7:GDP:GDIs,CHMs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10567621", "map_id": "none", "name": "GGC-RAB7:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "species_10567635", "map_id": "none", "name": "MON1:CCZ1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9XVL8", "map_id": "Q9XVL8", "name": "ccz-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00010283", "map_id": "WBGene00010283", "name": "ccz-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9BI89", "map_id": "Q9BI89", "name": "sand-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00018321", "map_id": "WBGene00018321", "name": "sand-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10567611", "map_id": "none", "name": "MADD exchanges GTP for GDP on RAB27", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5668575", "compartment_display": "melanosome membrane" }, { "id": "species_10567598", "map_id": "none", "name": "GGC-RAB27:GDP:GDIs,CHMs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10567608", "map_id": "none", "name": "RAB27:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5668575", "compartment_display": "melanosome membrane", "complex": "true" }, { "id": "species_10553865", "map_id": "O02626", "name": "aex-3", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10567485", "map_id": "none", "name": "DENND3 exchanges GTP for GDP on RAB12", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_262783", "compartment_display": "recycling endosome membrane" }, { "id": "species_10567472", "map_id": "none", "name": "GCC-RAB12:GDP:GDIs,CHMs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10567480", "map_id": "none", "name": "GGC-RAB12:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_262783", "compartment_display": "recycling endosome membrane", "complex": "true" }, { "id": "species_10567482", "map_id": "none", "name": "DENND3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "U4PBM1", "map_id": "U4PBM1", "name": "denn-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10567516", "map_id": "none", "name": "RAB13 GEFs exchange GTP for GDP on RAB13", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_204883", "compartment_display": "cell junction" }, { "id": "species_10567503", "map_id": "none", "name": "GGC-RAB13:GDP:GDIs,CHMs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10567511", "map_id": "none", "name": "GGC-RAB13:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_204883", "compartment_display": "cell junction", "complex": "true" }, { "id": "species_10567513", "map_id": "none", "name": "RAB13 GEFs", "type": "catalyst", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10567454", "map_id": "none", "name": "RIC1-RGP1 exchanges GTP for GDP on RAB6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane" }, { "id": "species_10567435", "map_id": "none", "name": "GGC-RAB6:GDP:GDIs,CHMs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10567451", "map_id": "none", "name": "GGC-RAB6:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane", "complex": "true" }, { "id": "species_10564567", "map_id": "none", "name": "RIC1:RGP1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10567774", "map_id": "none", "name": "RAB3GAP1:RAB3GAP2 exchanges GTP for GDP on RAB18", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10567761", "map_id": "none", "name": "GGC-RAB18:GDP:GDIs,CHMs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10567765", "map_id": "none", "name": "GGC-RAB18:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "species_10567771", "map_id": "none", "name": "RAB3GAP1:RAB3GAP2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10518562", "map_id": "none", "name": "SDK2 homophillic interaction", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10518558", "map_id": "none", "name": "Homologues of SDK2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q19663", "map_id": "Q19663", "name": "SDK2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00017657", "map_id": "WBGene00017657", "name": "SDK2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9N3X8", "map_id": "Q9N3X8", "name": "rig-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004371", "map_id": "WBGene00004371", "name": "rig-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10518560", "map_id": "none", "name": "Trans-homophilic SDK2 dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10518572", "map_id": "none", "name": "SDK1 homophillic interaction", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10518568", "map_id": "none", "name": "Homologues of SDK1(?-2213)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10518570", "map_id": "none", "name": "Trans-homophilic SDK1 dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10524053", "map_id": "none", "name": "Interaction of Plectin with Integrin beta 4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10517311", "map_id": "none", "name": "Integrin alpha6beta4", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10514921", "map_id": "A0A1N7SYP3", "name": "vab-10", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10524051", "map_id": "none", "name": "Integrin alpha 6:beta 4:Plectin complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10524069", "map_id": "none", "name": "BP230 is recruited to the hemidesmosome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10524061", "map_id": "none", "name": "Integrin alpha 6:beta 4:Plectin:BP180:Laminin-322 complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10524065", "map_id": "none", "name": "BP230", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10524067", "map_id": "none", "name": "BP230:BP180:Plectin:integrin alpha 6 beta 4:Laminin 332", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10525053", "map_id": "none", "name": "BP180 interacts extracellularly with Laminin 332", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10525051", "map_id": "none", "name": "Integrin alpha6:beta4:Plectin:BP180 complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10525220", "map_id": "none", "name": "Formation of the PINCH-ILK-parvin complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10525214", "map_id": "none", "name": "alpha/beta parvin", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10524045", "map_id": "Q9TZC4", "name": "pat-4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00003931", "map_id": "WBGene00003931", "name": "pat-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10525212", "map_id": "none", "name": "PINCH", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10525218", "map_id": "none", "name": "PINCH-ILK-parvin complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q19157", "map_id": "Q19157", "name": "pin-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004030", "map_id": "WBGene00004030", "name": "pin-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9TZC4", "map_id": "Q9TZC4", "name": "pat-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10523749", "map_id": "none", "name": "Mig-2 recruits Migfilin to the cell-ECM adhesions", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10523740", "map_id": "Q9U3F4", "name": "zyx-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00006999", "map_id": "WBGene00006999", "name": "zyx-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10523745", "map_id": "Q18685", "name": "unc-112", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10523747", "map_id": "none", "name": "MIG-2:MIGFILIN", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9U3F4", "map_id": "Q9U3F4", "name": "zyx-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10524049", "map_id": "none", "name": "ILK interacts with beta-1 integrin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10514200", "map_id": "Q27874", "name": "pat-3", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10524047", "map_id": "none", "name": "ILK:Integrin beta-1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10523759", "map_id": "none", "name": "MigFilin associates with Filamin and F-actin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10523753", "map_id": "none", "name": "Filamin", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10523757", "map_id": "none", "name": "Migfilin:Filamin A:F-actin", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10525199", "map_id": "none", "name": "Migfilin interacts with VASP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10525195", "map_id": "G5EG53", "name": "unc-34", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "WBGene00006770", "map_id": "WBGene00006770", "name": "unc-34", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10525197", "map_id": "none", "name": "MIGFILIN:VASP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "G5EG53", "map_id": "G5EG53", "name": "unc-34", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10513001", "map_id": "none", "name": "Internalization of gap junction plaques", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10512947", "map_id": "U4PBY2", "name": "hum-8", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "WBGene00002041", "map_id": "WBGene00002041", "name": "hum-8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10512999", "map_id": "none", "name": "Invaginating gap junction plaques", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "U4PBY2", "map_id": "U4PBY2", "name": "hum-8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10513003", "map_id": "none", "name": "Lysosomal degradation of gap junction plaques", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10508138", "map_id": "none", "name": "Phosphorylation (Ser5) of RNA pol II CTD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10509405", "map_id": "none", "name": "Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10558214", "map_id": "none", "name": "CHIT1 hydrolyses CHIT to 3xADGP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_6786654", "map_id": "CHEBI:84373", "name": "CHIT", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_6786660", "map_id": "CHEBI:47977", "name": "ADGP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10558211", "map_id": "Q11174", "name": "cht-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10512728", "map_id": "none", "name": "lactose + H2O => D-glucose + D-galactose", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_188973", "map_id": "CHEBI:17716", "name": "Lac", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10512725", "map_id": "none", "name": "LCT dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10513005", "map_id": "none", "name": "Digestion of branched starch (amylopectin) by extracellular amylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_189071", "map_id": "none", "name": "starch (amylopectin)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_191103", "map_id": "CHEBI:27931", "name": "maltotriose", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_188986", "map_id": "CHEBI:17306", "name": "Mal", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_189108", "map_id": "CHEBI:28912", "name": "limit dextrins", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10512715", "map_id": "P91982", "name": "AMY2A", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "WBGene00008220", "map_id": "WBGene00008220", "name": "AMY2A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10512718", "map_id": "none", "name": "Digestion of linear starch (amylose) by extracellular amylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_189075", "map_id": "none", "name": "starch (amylose)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10556729", "map_id": "none", "name": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10556726", "map_id": "none", "name": "(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC:Incised DNA without lesion", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10556722", "map_id": "none", "name": "(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC:SSB-dsDNA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10556724", "map_id": "none", "name": "TFIIH binds GG-NER site to form a verification complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10556158", "map_id": "none", "name": "Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH:PAR-PARP1,PAR-PARP2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10556164", "map_id": "none", "name": "Recruitment of XPA and release of CAK ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10556135", "map_id": "Q21302", "name": "xpa-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10556162", "map_id": "none", "name": "Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10558516", "map_id": "none", "name": "SUMOylation of XPC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10556715", "map_id": "none", "name": "Ub:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1L", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10558502", "map_id": "none", "name": "SUMO1,2,3:UBE2I", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10558511", "map_id": "none", "name": "Ub,SUMO:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10558513", "map_id": "none", "name": "PIAS1,3", "type": "catalyst", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10508629", "map_id": "none", "name": "Formation of ERCC1:XPF heterodimeric complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10508620", "map_id": "Q93456", "name": "ercc-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10508625", "map_id": "G5EBZ1", "name": "xpf-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10556718", "map_id": "none", "name": "ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10556711", "map_id": "none", "name": "Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1L", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10544211", "map_id": "none", "name": "SPARC binds Collagen type I fibril, hydroxylapatite and Ca2+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_2672070", "map_id": "CHEBI:52255", "name": "Hydroxylapatite", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10526518", "map_id": "P34714", "name": "ost-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10544209", "map_id": "none", "name": "Collagen type I fibril:SPARC:Hydroxylapatitie:Ca2+", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10544420", "map_id": "none", "name": "AGRN binds Beta amyloid fibril via GAG chains", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10544412", "map_id": "P34710", "name": "unc-6", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10544416", "map_id": "none", "name": "Beta amyloid fibril", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10544418", "map_id": "none", "name": "AGRN:Beta amyloid fibril", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10545273", "map_id": "none", "name": "TNC binds Integrin alphaVbeta3, alphaVbeta6, alpha2beta1, alpha7beta1, alpha8beta1, alpha9beta1, alphaXbeta1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10545269", "map_id": "none", "name": "Integrin alphaVbeta3, alphaVbeta6, alpha2beta1, alpha7beta1, alpha8beta1, alpha9beta1, alphaXbeta1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10545271", "map_id": "none", "name": "TNC:Integrin alphaVbeta3, alphaVbeta6, alpha2beta1, alpha7beta1, alpha8beta1, alpha9beta1, alphaXbeta1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10545277", "map_id": "none", "name": "Tenascins C, R, (X, N) bind fibronectin matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10544239", "map_id": "none", "name": "Tenascins C, R, (X, N)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10545275", "map_id": "none", "name": "Tenascins C, R, (X, N):Fibronectin matrix", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10557840", "map_id": "none", "name": "RNA Pol II initiates transcription from damaged DNA template", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10557838", "map_id": "none", "name": "Damaged dsDNA with open transcription bubble:Hyperphosphorylated RNA Pol II:TFIIH", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10557845", "map_id": "none", "name": "Active RNA Pol II complex transcribes lesion-containing DNA template", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_6781829", "map_id": "CHEBI:17972", "name": "ribonucleoside triphosphate", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10557842", "map_id": "none", "name": "Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10557865", "map_id": "none", "name": "ERCC8 (CSA) binds stalled RNA Pol II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10557852", "map_id": "none", "name": "Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10557861", "map_id": "none", "name": "ERCC8:DDB1:CUL4:RBX1:COP9 Signalosome", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10557863", "map_id": "none", "name": "Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10557913", "map_id": "none", "name": "UVSSA:USP7 deubiquitinates ERCC6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10557904", "map_id": "none", "name": "Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1:UVSSA:USP7:XAB2 complex:XPA:TCEA1:HMGN1:EP300", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10557867", "map_id": "none", "name": "ERCC6 binds stalled RNA Pol II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10557850", "map_id": "Q86D18", "name": "ERCC6", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10557886", "map_id": "none", "name": "ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10557883", "map_id": "none", "name": "Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10543938", "map_id": "none", "name": "FN1 aggregation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10543936", "map_id": "none", "name": "Integrin alpha5beta1:Fibronectin matrix", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10544859", "map_id": "none", "name": "FN1 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "reaction_10564552", "map_id": "none", "name": "NSF and SNAPs bind the cis-SNARE at the Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10564548", "map_id": "none", "name": "STX:PalmC-YKT6:BET1L:GOSR1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "species_10564550", "map_id": "none", "name": "STX5:PalmC-YKT6:BET1L:GOSR1:NSF hexamer:3xSNAPs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "reaction_10564571", "map_id": "none", "name": "RAB33B:GTP binds RIC1:RGP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10564561", "map_id": "none", "name": "RAB33B:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "species_10564569", "map_id": "none", "name": "RAB33B:GTP:RIC1:RGP1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "reaction_10564079", "map_id": "none", "name": "The COG tethering complex interacts with numerous SNAREs at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10563498", "map_id": "none", "name": "COG complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "species_10564075", "map_id": "none", "name": "other COG interacting snares", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "species_10564077", "map_id": "none", "name": "COG complex:Golgi snares", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "reaction_10564958", "map_id": "none", "name": "The COG complex binds RABs at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10564954", "map_id": "none", "name": "other COG-interacting RABs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "Q9XWZ3", "map_id": "Q9XWZ3", "name": "rab-30", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WBGene00004282", "map_id": "WBGene00004282", "name": "rab-30", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10564956", "map_id": "none", "name": "COG complex:RABs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "reaction_10543921", "map_id": "none", "name": "FN1 binds Collagen types I-V, VII", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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"reaction_10539495", "reaction_10544002", "reaction_10543642", "reaction_10568840", "reaction_10544776", "reaction_10543302", "reaction_10568838", "reaction_10543921", "reaction_10543754", "reaction_10545277", "reaction_10544063", "reaction_10568762", "reaction_10538460", "reaction_10573092", "reaction_10544040", "reaction_10536136", "reaction_10544565", "reaction_10544552", "reaction_10568772", "reaction_10545560", "reaction_10544859", "reaction_10517398", "reaction_10517298", "reaction_10536277", "reaction_10536120", "reaction_10534362", "reaction_10544563", "reaction_10536047", "reaction_10536244" ] } }, "reaction_dictionary": { "reaction_10509451": { "compartment": "compartment_17906", "id": "reaction_10509451", "reactome": "R-CEL-114284", "name": "Release of Cytochrome c from mitochondria", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509449" ], "products": [ "species_10509434" ], "modifiers": [], "additional_components": [ "P19974", "WBGene00017121", "Q23240", "WBGene00013854", "P19974", "WBGene00017121", "Q23240", "WBGene00013854" ] }, "reaction_10554208": { "compartment": "compartment_7660", "id": "reaction_10554208", "reactome": "R-CEL-5651805", "name": "LIG1 bound to APEX1 and PCNA ligates SSB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508820" ], "products": [ "species_10554205" ], "modifiers": [ [ "species_10508820", "catalyst" ] ], "additional_components": [ "G5EBR7", "WBGene00001372", "Q95Y97", "WBGene00019767", "P90829", "WBGene00008645", "Q19366", "WBGene00008722", "Q21730", "WBGene00011016", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "O02115", "WBGene00003955", "Q27474", "WBGene00002985", "G5EBR7", "WBGene00001372", "Q95Y97", "WBGene00019767", "P90829", "WBGene00008645", "Q19366", "WBGene00008722", "Q21730", "WBGene00011016", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "O02115", "WBGene00003955", "Q27474", "WBGene00002985", "G5EBR7", "WBGene00001372", "Q95Y97", "WBGene00019767", "P90829", "WBGene00008645", "Q19366", "WBGene00008722", "Q21730", "WBGene00011016", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "O02115", "WBGene00003955", "Q27474", "WBGene00002985" ] }, "reaction_10508822": { "compartment": "compartment_7660", "id": "reaction_10508822", "reactome": "R-CEL-110371", "name": "LIG1 binds APEX1 and PCNA at SSB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502732", "species_10508818" ], "products": [ "species_10508820" ], "modifiers": [], "additional_components": [ "WBGene00002985", "G5EBR7", "WBGene00001372", "Q95Y97", "WBGene00019767", "P90829", "WBGene00008645", "Q19366", "WBGene00008722", "Q21730", "WBGene00011016", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "O02115", "WBGene00003955", "G5EBR7", "WBGene00001372", "Q95Y97", "WBGene00019767", "P90829", "WBGene00008645", "Q19366", "WBGene00008722", "Q21730", "WBGene00011016", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "O02115", "WBGene00003955", "Q27474", "WBGene00002985" ] }, "reaction_10508814": { "compartment": "compartment_7660", "id": "reaction_10508814", "reactome": "R-CEL-110368", "name": "POLD,POLE-mediated DNA strand displacement synthesis", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30555", "species_10508811" ], "products": [ "species_10508807", "species_113541" ], "modifiers": [ [ "species_10508811", "catalyst" ] ], "additional_components": [ "G5EBR7", "WBGene00001372", "Q95Y97", "WBGene00019767", "P90829", "WBGene00008645", "Q19366", "WBGene00008722", "Q21730", "WBGene00011016", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "O02115", "WBGene00003955", "Q9N3T2", "WBGene00000794", "G5EBR7", "WBGene00001372", "Q95Y97", "WBGene00019767", "P90829", "WBGene00008645", "Q19366", "WBGene00008722", "Q21730", "WBGene00011016", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "O02115", "WBGene00003955", "Q9N3T2", "WBGene00000794", "G5EBR7", "WBGene00001372", "Q95Y97", "WBGene00019767", "P90829", "WBGene00008645", "Q19366", "WBGene00008722", "Q21730", "WBGene00011016", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "O02115", "WBGene00003955", "Q9N3T2", "WBGene00000794" ] }, "reaction_10546996": { "compartment": "compartment_70101", "id": "reaction_10546996", "reactome": "R-CEL-3249379", "name": "p-S407-STAT6 is phosphorylated at Tyr641", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10546994" ], "products": [ "species_10546974", "species_29370" ], "modifiers": [], "additional_components": [ "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111" ] }, "reaction_10546986": { "compartment": "compartment_70101", "id": "reaction_10546986", "reactome": "R-CEL-3249370", "name": "p-S407,Y641-STAT6 dimer migrates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546976" ], "products": [ "species_10546984" ], "modifiers": [], "additional_components": [ "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111" ] }, "reaction_10546988": { "compartment": "compartment_70101", "id": "reaction_10546988", "reactome": "R-CEL-3249372", "name": "p-S407,Y641-STAT6 is dimerized", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546974" ], "products": [ "species_10546976" ], "modifiers": [], "additional_components": [ "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111" ] }, "reaction_10567345": { "compartment": "compartment_70101", "id": "reaction_10567345", "reactome": "R-CEL-8875576", "name": "CRK,CRKL recruits RAC1 GEF to activated MET", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10567341", "species_10567330" ], "products": [ "species_10567343" ], "modifiers": [], "additional_components": [ "G5EDJ4", "WBGene00004928", "Q9XVQ7", "WBGene00008711", "P29355", "WBGene00004774", "Q9NHC3", "WBGene00000416", "Q95XA9", "WBGene00021238", "G5EDJ4", "WBGene00004928", "Q9XVQ7", "WBGene00008711", "P29355", "WBGene00004774", "Q9NHC3", "WBGene00000416", "Q95XA9", "WBGene00021238" ] }, "reaction_10567332": { "compartment": "compartment_70101", "id": "reaction_10567332", "reactome": "R-CEL-8875540", "name": "GAB1 recruits CRK,CRKL to MET", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10520269", "species_10543879" ], "products": [ "species_10567330" ], "modifiers": [], "additional_components": [ "Q9NHC3", "WBGene00000416", "Q95XA9", "WBGene00021238", "G5EDJ4", "WBGene00004928", "Q9XVQ7", "WBGene00008711", "P29355", "WBGene00004774", "G5EDJ4", "WBGene00004928", "Q9XVQ7", "WBGene00008711", "P29355", "WBGene00004774", "Q9NHC3", "WBGene00000416", "Q95XA9", "WBGene00021238" ] }, "reaction_10567348": { "compartment": "compartment_70101", "id": "reaction_10567348", "reactome": "R-CEL-8875591", "name": "DOCK7 activates RAC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10541992" ], "products": [ "species_29420", "species_10509457" ], "modifiers": [ [ "species_10567343", "catalyst" ] ], "additional_components": [ "species_29420", "Q03206", "ced-10", "species_29438", "Q03206", "ced-10", "G5EDJ4", "WBGene00004928", "Q9XVQ7", "WBGene00008711", "P29355", "WBGene00004774", "Q9NHC3", "WBGene00000416", "Q95XA9", "WBGene00021238" ] }, "reaction_10567336": { "compartment": "compartment_70101", "id": "reaction_10567336", "reactome": "R-CEL-8875558", "name": "RAPGEF1 binds CRK,CRKL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10567330", "species_10528529" ], "products": [ "species_10567334" ], "modifiers": [], "additional_components": [ "G5EDJ4", "WBGene00004928", "Q9XVQ7", "WBGene00008711", "P29355", "WBGene00004774", "Q9NHC3", "WBGene00000416", "Q95XA9", "WBGene00021238", "WBGene00021320", "H2KZX7", "WBGene00021320", "G5EDJ4", "WBGene00004928", "Q9XVQ7", "WBGene00008711", "P29355", "WBGene00004774", "Q9NHC3", "WBGene00000416", "Q95XA9", "WBGene00021238" ] }, "reaction_10567339": { "compartment": "compartment_876", "id": "reaction_10567339", "reactome": "R-CEL-8875568", "name": "RAPGEF1 activates RAP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10518265" ], "products": [ "species_29420", "species_10518164" ], "modifiers": [ [ "species_10567334", "catalyst" ] ], "additional_components": [ "Q18246", "WBGene00004307", "species_29420", "Q18246", "WBGene00004307", "species_29438", "H2KZX7", "WBGene00021320", "G5EDJ4", "WBGene00004928", "Q9XVQ7", "WBGene00008711", "P29355", "WBGene00004774", "Q9NHC3", "WBGene00000416", "Q95XA9", "WBGene00021238" ] }, "reaction_10502772": { "compartment": "compartment_7660", "id": "reaction_10502772", "reactome": "R-CEL-69562", "name": "Inactivation of Cyclin E:Cdk2 complexes by p27/p21", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502767", "species_10502749" ], "products": [ "species_10502769" ], "modifiers": [ [ "species_10502767", "catalyst" ] ], "additional_components": [ "WBGene00000517", "O61847", "WBGene00019362", "O61847", "WBGene00019362", "G5EEJ2", "WBGene00000517", "WBGene00000517" ] }, "reaction_10517476": { "compartment": "compartment_70101", "id": "reaction_10517476", "reactome": "R-CEL-264444", "name": "Autoubiquitination of phospho-COP1(Ser-387 )", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10517469", "species_10502375" ], "products": [ "species_10517473" ], "modifiers": [ [ "species_10517469", "catalyst" ] ], "additional_components": [ "WBGene00003917", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "Q965F9", "WBGene00003917", "WBGene00003917" ] }, "reaction_10517478": { "compartment": "compartment_70101", "id": "reaction_10517478", "reactome": "R-CEL-264458", "name": "Proteasome mediated degradation of COP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10517473" ], "products": [ "species_10502375" ], "modifiers": [ [ "species_10502572", "catalyst" ] ], "additional_components": [ "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "Q965F9", "WBGene00003917", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "P91477", "WBGene00003950", "Q95PZ7", "WBGene00013435", "Q18115", "WBGene00004459", "O62102", "WBGene00003948", "O17071", "WBGene00004504", "Q10920", "WBGene00016623", "P34286", "WBGene00003952", "Q9XTT9", "WBGene00004506", "Q23449", "WBGene00004468", "Q95005", "WBGene00003925", "P46502", "WBGene00004503", "O61792", "WBGene00004464", "O17586", "WBGene00003922", "O76371", "WBGene00004505", "Q20585", "WBGene00004463", "Q95008", "WBGene00003926", "Q18787", "WBGene00004501", "Q20058", "WBGene00009445", "Q9N599", "WBGene00003924", "O16368", "WBGene00004502", "O61742", "WBGene00004466", "Q09583", "WBGene00003928", "Q966I8", "WBGene00003947", "Q04908", "WBGene00004460", "Q9XUV0", "WBGene00003951", "Q27488", "WBGene00003923", "Q9GZH5", "WBGene00004458", "O44156", "WBGene00003927", "Q22253", "WBGene00004465", "O76577", "WBGene00004467", "P90868", "WBGene00003953", "Q19324", "WBGene00004461", "Q17971", "WBGene00007588", "Q23237", "WBGene00003949", "Q20938", "WBGene00004462" ] }, "reaction_10517471": { "compartment": "compartment_13231", "id": "reaction_10517471", "reactome": "R-CEL-264418", "name": "Translocation of COP1 from the nucleus to the cytoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10517467" ], "products": [ "species_10517469" ], "modifiers": [], "additional_components": [ "WBGene00003917", "WBGene00003917" ] }, "reaction_10512670": { "compartment": "compartment_7660", "id": "reaction_10512670", "reactome": "R-CEL-187934", "name": "Inactivation of Cyclin A:Cdk2 complexes by p27/p21", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502767", "species_10511613" ], "products": [ "species_10512663" ], "modifiers": [ [ "species_10502767", "catalyst" ] ], "additional_components": [ "WBGene00000517", "O61847", "WBGene00019362", "O61847", "WBGene00019362", "G5EEJ2", "WBGene00000517", "WBGene00000517" ] }, "reaction_10552354": { "compartment": "compartment_984", "id": "reaction_10552354", "reactome": "R-CEL-5433072", "name": "GGTs hydrolyse glutamate from AFXBO-SG, AFNBO-SG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5490253", "species_109276" ], "products": [ "species_210382", "species_5490235" ], "modifiers": [ [ "species_10552351", "catalyst" ] ], "additional_components": [ "CHEBI:78581", "CHEBI:78587", "CHEBI:78579", "CHEBI:78584", "H2L0B7", "WBGene00020590", "O18256", "WBGene00020590", "Q9N5V4", "WBGene00020590", "A0A486WVP7", "WBGene00020590", "B5BM47", "WBGene00020590" ] }, "reaction_10552364": { "compartment": "compartment_70101", "id": "reaction_10552364", "reactome": "R-CEL-5433074", "name": "ACY1:Zn2+ dimer hydrolyses mercapturic acids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5490236", "species_29356" ], "products": [ "species_2022890", "species_5490231" ], "modifiers": [ [ "species_10552361", "catalyst" ] ], "additional_components": [ "CHEBI:78580", "CHEBI:78585", "CHEBI:78583", "CHEBI:78578", "species_216785", "Q5WRS4", "WBGene00015509" ] }, "reaction_10525168": { "compartment": "compartment_12045", "id": "reaction_10525168", "reactome": "R-CEL-446214", "name": "Synthesis of dolichyl-phosphate-glucose", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449299", "species_29410" ], "products": [ "species_532214", "species_110096" ], "modifiers": [ [ "species_10525165", "catalyst" ] ], "additional_components": [ "WBGene00019276" ] }, "reaction_10563798": { "compartment": "compartment_70101", "id": "reaction_10563798", "reactome": "R-CEL-6810464", "name": "NUDT14 hydrolyses UDP-Glc to G1P and UMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_29410" ], "products": [ "species_29548", "species_109402" ], "modifiers": [ [ "species_10563795", "catalyst" ] ], "additional_components": [ "WBGene00008238" ] }, "reaction_10529329": { "compartment": "compartment_70101", "id": "reaction_10529329", "reactome": "R-CEL-927889", "name": "SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10529324", "species_113592" ], "products": [ "species_10529326", "species_29370" ], "modifiers": [ [ "species_10529324", "catalyst" ] ], "additional_components": [ "P91914", "WBGene00004441", "Q19869", "WBGene00004440", "O01868", "WBGene00004436", "P48162", "WBGene00004438", "P52819", "WBGene00004434", "P48158", "WBGene00004435", "Q09533", "WBGene00004421", "P34334", "WBGene00004433", "O02639", "WBGene00004431", "Q95Y90", "WBGene00004420", "O44480", "WBGene00004432", "Q22716", "WBGene00004446", "Q9U332", "WBGene00004445", "Q9XWS4", "WBGene00004444", "P52814", "WBGene00004453", "O45226", "WBGene00004443", "Q21930", "WBGene00004442", "P48166", "WBGene00004454", "Q9BKU5", "WBGene00021350", "P50880", "WBGene00004414", "P61866", "WBGene00004424", "O17570", "WBGene00004452", "Q19162", "WBGene00004423", "Q9U2A8", "WBGene00004456", "Q9N4I4", "WBGene00004412", "O62388", "WBGene00012179", "O01504", "WBGene00016493", "P49181", "WBGene00004450", "P91913", "WBGene00004409", "P49180", "WBGene00004447", "Q93572", "WBGene00004408", "P34662", "WBGene00004449", "Q9XVF7", "WBGene00004413", "O45946", "WBGene00004430", "Q966C6", "WBGene00004419", "Q9BL19", "WBGene00004429", "O01802", "WBGene00004418", "P91374", "WBGene00004427", "P47991", "WBGene00004417", "Q9XVE9", "WBGene00004426", "P49405", "WBGene00004416", "Q27389", "WBGene00004428", "P37165", "WBGene00006725", "P91128", "WBGene00004425", "O02056", "WBGene00004415", "P51403", "WBGene00004471", "Q9NEN6", "WBGene00004475", "Q8WQA8", "WBGene00004489", "Q23312", "WBGene00004476", "O01869", "WBGene00004479", "P49197", "WBGene00004490", "P48156", "WBGene00004477", "Q20206", "WBGene00004480", "Q19877", "WBGene00004492", "Q20228", "WBGene00004478", "P49196", "WBGene00004481", "Q1XFY9", "WBGene00004493", "P46769", "WBGene00004469", "P51404", "WBGene00004482", "P52821", "WBGene00004494", "Q9TXP0", "WBGene00004496", "P48150", "WBGene00004483", 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"P48158", "WBGene00004435", "Q09533", "WBGene00004421", "P34334", "WBGene00004433", "O02639", "WBGene00004431", "Q95Y90", "WBGene00004420", "O44480", "WBGene00004432", "Q22716", "WBGene00004446", "Q9U332", "WBGene00004445", "Q9XWS4", "WBGene00004444", "P52814", "WBGene00004453", "O45226", "WBGene00004443", "Q21930", "WBGene00004442", "P48166", "WBGene00004454", "Q9BKU5", "WBGene00021350", "P50880", "WBGene00004414", "P61866", "WBGene00004424", "O17570", "WBGene00004452", "Q19162", "WBGene00004423", "Q9U2A8", "WBGene00004456", "Q9N4I4", "WBGene00004412", "O62388", "WBGene00012179", "O01504", "WBGene00016493", "P49181", "WBGene00004450", "P91913", "WBGene00004409", "P49180", "WBGene00004447", "Q93572", "WBGene00004408", "P34662", "WBGene00004449", "Q9XVF7", "WBGene00004413", "O45946", "WBGene00004430", "Q966C6", "WBGene00004419", "Q9BL19", "WBGene00004429", "O01802", "WBGene00004418", "P91374", "WBGene00004427", "P47991", "WBGene00004417", "Q9XVE9", "WBGene00004426", "P49405", "WBGene00004416", "Q27389", "WBGene00004428", "P37165", "WBGene00006725", "P91128", "WBGene00004425", "O02056", "WBGene00004415", "P51403", "WBGene00004471", "Q9NEN6", "WBGene00004475", "Q8WQA8", "WBGene00004489", "Q23312", "WBGene00004476", "O01869", "WBGene00004479", "P49197", "WBGene00004490", "P48156", "WBGene00004477", "Q20206", "WBGene00004480", "Q19877", "WBGene00004492", "Q20228", "WBGene00004478", "P49196", "WBGene00004481", "Q1XFY9", "WBGene00004493", "P46769", "WBGene00004469", "P51404", "WBGene00004482", "P52821", "WBGene00004494", "Q9TXP0", "WBGene00004496", "P48150", "WBGene00004483", "O45499", "WBGene00004495", "Q9N3X2", "WBGene00004473", "Q9XVP0", "WBGene00004484", "Q95Y04", "WBGene00004497", "Q22054", "WBGene00004485", "P90983", "WBGene00004498", "O01692", "WBGene00004486", "P48152", "WBGene00004472", "O18240", "WBGene00004487", "O18650", "WBGene00004488", "P48154", "WBGene00004470", "O17218", "WBGene00004491", "P49041", "WBGene00004474", "C2BR97", "WBGene00004881", 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"O17570", "WBGene00004452", "Q19162", "WBGene00004423", "Q9U2A8", "WBGene00004456", "Q9N4I4", "WBGene00004412", "O62388", "WBGene00012179", "O01504", "WBGene00016493", "P49181", "WBGene00004450", "P91913", "WBGene00004409", "P49180", "WBGene00004447", "Q93572", "WBGene00004408", "P34662", "WBGene00004449", "Q9XVF7", "WBGene00004413", "O45946", "WBGene00004430", "Q966C6", "WBGene00004419", "Q9BL19", "WBGene00004429", "O01802", "WBGene00004418", "P91374", "WBGene00004427", "P47991", "WBGene00004417", "Q9XVE9", "WBGene00004426", "P49405", "WBGene00004416", "Q27389", "WBGene00004428", "P37165", "WBGene00006725", "P91128", "WBGene00004425", "O02056", "WBGene00004415", "P51403", "WBGene00004471", "Q9NEN6", "WBGene00004475", "Q8WQA8", "WBGene00004489", "Q23312", "WBGene00004476", "O01869", "WBGene00004479", "P49197", "WBGene00004490", "P48156", "WBGene00004477", "Q20206", "WBGene00004480", "Q19877", "WBGene00004492", "Q20228", "WBGene00004478", "P49196", "WBGene00004481", "Q1XFY9", "WBGene00004493", "P46769", "WBGene00004469", "P51404", "WBGene00004482", "P52821", "WBGene00004494", "Q9TXP0", "WBGene00004496", "P48150", "WBGene00004483", "O45499", "WBGene00004495", "Q9N3X2", "WBGene00004473", "Q9XVP0", "WBGene00004484", "Q95Y04", "WBGene00004497", "Q22054", "WBGene00004485", "P90983", "WBGene00004498", "O01692", "WBGene00004486", "P48152", "WBGene00004472", "O18240", "WBGene00004487", "O18650", "WBGene00004488", "P48154", "WBGene00004470", "O17218", "WBGene00004491", "P49041", "WBGene00004474", "C2BR97", "WBGene00004881", "Q8WQF3", "WBGene00004882", "G5EDE4", "WBGene00012343", "Q21832", "WBGene00004387", "P49029", "WBGene00003123", "Q9BL61", "WBGene00022029", "Q21155", "WBGene00004388", "O45622", "WBGene00010405", "species_29420", "A0A486WX07", "WBGene00002066", "Q9U302", "WBGene00003902", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "O16520", "WBGene00020269", "O62301", "WBGene00010551", "Q9XWJ1", "WBGene00013188", "O76512", "WBGene00004880" ] }, "reaction_10529308": { "compartment": "compartment_70101", "id": "reaction_10529308", "reactome": "R-CEL-927836", "name": "SMG6 hydrolyzes mRNA with premature termination codon", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10529305" ], "products": [ "species_10529290" ], "modifiers": [ [ "species_10529305", "catalyst" ] ], "additional_components": [ "Q8WQF3", "WBGene00004882", "O76512", "WBGene00004880", "P91914", "WBGene00004441", "Q19869", "WBGene00004440", "O01868", "WBGene00004436", "P48162", "WBGene00004438", "P52819", "WBGene00004434", "P48158", "WBGene00004435", "Q09533", "WBGene00004421", "P34334", "WBGene00004433", "O02639", "WBGene00004431", "Q95Y90", "WBGene00004420", "O44480", "WBGene00004432", "Q22716", "WBGene00004446", "Q9U332", "WBGene00004445", "Q9XWS4", "WBGene00004444", "P52814", "WBGene00004453", "O45226", "WBGene00004443", "Q21930", "WBGene00004442", "P48166", "WBGene00004454", "Q9BKU5", "WBGene00021350", "P50880", "WBGene00004414", "P61866", "WBGene00004424", "O17570", "WBGene00004452", "Q19162", "WBGene00004423", "Q9U2A8", "WBGene00004456", "Q9N4I4", "WBGene00004412", "O62388", "WBGene00012179", "O01504", "WBGene00016493", "P49181", "WBGene00004450", "P91913", "WBGene00004409", "P49180", "WBGene00004447", "Q93572", "WBGene00004408", "P34662", "WBGene00004449", "Q9XVF7", "WBGene00004413", "O45946", "WBGene00004430", "Q966C6", "WBGene00004419", "Q9BL19", "WBGene00004429", "O01802", "WBGene00004418", "P91374", "WBGene00004427", "P47991", "WBGene00004417", "Q9XVE9", "WBGene00004426", "P49405", "WBGene00004416", "Q27389", "WBGene00004428", "P37165", "WBGene00006725", "P91128", "WBGene00004425", "O02056", "WBGene00004415", "P51403", "WBGene00004471", "Q9NEN6", "WBGene00004475", "Q8WQA8", "WBGene00004489", "Q23312", "WBGene00004476", "O01869", "WBGene00004479", "P49197", "WBGene00004490", "P48156", "WBGene00004477", "Q20206", "WBGene00004480", "Q19877", "WBGene00004492", "Q20228", "WBGene00004478", "P49196", "WBGene00004481", "Q1XFY9", "WBGene00004493", "P46769", "WBGene00004469", "P51404", "WBGene00004482", "P52821", "WBGene00004494", "Q9TXP0", "WBGene00004496", "P48150", "WBGene00004483", "O45499", "WBGene00004495", "Q9N3X2", "WBGene00004473", "Q9XVP0", "WBGene00004484", "Q95Y04", "WBGene00004497", "Q22054", "WBGene00004485", "P90983", "WBGene00004498", "O01692", "WBGene00004486", "P48152", "WBGene00004472", "O18240", "WBGene00004487", "O18650", "WBGene00004488", "P48154", "WBGene00004470", "O17218", "WBGene00004491", "P49041", "WBGene00004474", "C2BR97", "WBGene00004881", "G5EDE4", "WBGene00012343", "Q21832", "WBGene00004387", "P49029", "WBGene00003123", "Q9BL61", "WBGene00022029", "Q21155", "WBGene00004388", "O45622", "WBGene00010405", "species_29420", "A0A486WX07", "WBGene00002066", "Q9U302", "WBGene00003902", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "O16520", "WBGene00020269", "Q09543", "WBGene00003901", "G5EDR3", "WBGene00006352", "G5EGK8", "WBGene00002363", "Q9BL68", "WBGene00004884", "A0A486WX07", "WBGene00002066", "O76512", "WBGene00004880", "Q09543", "WBGene00003901", "G5EDR3", "WBGene00006352", "G5EGK8", "WBGene00002363", "Q9U302", "WBGene00003902", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "Q9BL68", "WBGene00004884", "Q8WQF3", "WBGene00004882", "O76512", "WBGene00004880", "P91914", "WBGene00004441", "Q19869", "WBGene00004440", "O01868", "WBGene00004436", "P48162", "WBGene00004438", "P52819", "WBGene00004434", "P48158", "WBGene00004435", "Q09533", "WBGene00004421", "P34334", "WBGene00004433", "O02639", "WBGene00004431", "Q95Y90", "WBGene00004420", "O44480", "WBGene00004432", "Q22716", "WBGene00004446", "Q9U332", "WBGene00004445", "Q9XWS4", "WBGene00004444", "P52814", "WBGene00004453", "O45226", "WBGene00004443", "Q21930", "WBGene00004442", "P48166", "WBGene00004454", "Q9BKU5", "WBGene00021350", "P50880", "WBGene00004414", "P61866", "WBGene00004424", "O17570", "WBGene00004452", "Q19162", "WBGene00004423", "Q9U2A8", "WBGene00004456", "Q9N4I4", "WBGene00004412", "O62388", "WBGene00012179", "O01504", "WBGene00016493", "P49181", "WBGene00004450", "P91913", "WBGene00004409", "P49180", "WBGene00004447", "Q93572", "WBGene00004408", "P34662", "WBGene00004449", "Q9XVF7", "WBGene00004413", "O45946", "WBGene00004430", "Q966C6", "WBGene00004419", "Q9BL19", "WBGene00004429", "O01802", "WBGene00004418", "P91374", "WBGene00004427", "P47991", "WBGene00004417", "Q9XVE9", "WBGene00004426", "P49405", "WBGene00004416", "Q27389", "WBGene00004428", "P37165", "WBGene00006725", "P91128", "WBGene00004425", "O02056", "WBGene00004415", "P51403", "WBGene00004471", "Q9NEN6", "WBGene00004475", "Q8WQA8", "WBGene00004489", "Q23312", "WBGene00004476", "O01869", "WBGene00004479", "P49197", "WBGene00004490", "P48156", "WBGene00004477", "Q20206", "WBGene00004480", "Q19877", "WBGene00004492", "Q20228", "WBGene00004478", "P49196", "WBGene00004481", "Q1XFY9", "WBGene00004493", "P46769", "WBGene00004469", "P51404", "WBGene00004482", "P52821", "WBGene00004494", "Q9TXP0", "WBGene00004496", "P48150", "WBGene00004483", "O45499", "WBGene00004495", "Q9N3X2", "WBGene00004473", "Q9XVP0", "WBGene00004484", "Q95Y04", "WBGene00004497", "Q22054", "WBGene00004485", "P90983", "WBGene00004498", "O01692", "WBGene00004486", "P48152", "WBGene00004472", "O18240", "WBGene00004487", "O18650", "WBGene00004488", "P48154", "WBGene00004470", "O17218", "WBGene00004491", "P49041", "WBGene00004474", "C2BR97", "WBGene00004881", "G5EDE4", "WBGene00012343", "Q21832", "WBGene00004387", "P49029", "WBGene00003123", "Q9BL61", "WBGene00022029", "Q21155", "WBGene00004388", "O45622", "WBGene00010405", "species_29420", "A0A486WX07", "WBGene00002066", "Q9U302", "WBGene00003902", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "O16520", "WBGene00020269", "Q09543", "WBGene00003901", "G5EDR3", "WBGene00006352", "G5EGK8", "WBGene00002363", "Q9BL68", "WBGene00004884" ] }, "reaction_10572480": { "compartment": "compartment_70101", "id": "reaction_10572480", "reactome": "R-CEL-9641096", "name": "Misfolded proteins bind PRKN:UBE2N:UBE2V1:Ub", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10572476", "species_10572472" ], "products": [ "species_10572478" ], "modifiers": [], "additional_components": [ "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "Q95XX0", "WBGene00006708", "O45495", "WBGene00006730", "G5ED37", "WBGene00003885", "H2L0N8", "WBGene00021349", "P30644", "WBGene00011145", "P90994", "WBGene00015184", "G5ED37", "WBGene00003885", "H2L0N8", "WBGene00021349", "P30644", "WBGene00011145", "P90994", "WBGene00015184", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "Q95XX0", "WBGene00006708", "O45495", "WBGene00006730" ] }, "reaction_10572551": { "compartment": "compartment_70101", "id": "reaction_10572551", "reactome": "R-CEL-9646348", "name": "PolyUb-Misfolded Proteins:HDAC6 bind dynein motor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10572547", "species_10552960" ], "products": [ "species_10572549" ], "modifiers": [], "additional_components": [ "P90994", "WBGene00015184", "H2L0N8", "WBGene00021349", "P30644", "WBGene00011145", "G5ED37", "WBGene00003885", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "Q19625", "WBGene00003412", "Q95QV2", "WBGene00000477", "Q20296", "WBGene00018319", "Q19020", "WBGene00000962", "O45087", "WBGene00015927", "Q65XS9", "WBGene00043067", "A0AAC1", "WBGene00012424", "Q7YTJ8", "WBGene00012425", "Q21557", "WBGene00010888", "Q22799", "WBGene00001005", "G5ED34", "WBGene00001007", "Q19020", "WBGene00000962", "O45087", "WBGene00015927", "Q65XS9", "WBGene00043067", "A0AAC1", "WBGene00012424", "Q7YTJ8", "WBGene00012425", "Q21557", "WBGene00010888", "Q22799", "WBGene00001005", "G5ED34", "WBGene00001007", "P90994", "WBGene00015184", "H2L0N8", "WBGene00021349", "P30644", "WBGene00011145", "G5ED37", "WBGene00003885", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "Q19625", "WBGene00003412", "Q95QV2", "WBGene00000477", "Q20296", "WBGene00018319" ] }, "reaction_10572520": { "compartment": "compartment_70101", "id": "reaction_10572520", "reactome": "R-CEL-9641111", "name": "Parkin transfers Ub to misfolded proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10572478" ], "products": [ "species_10572518" ], "modifiers": [], "additional_components": [ "G5ED37", "WBGene00003885", "H2L0N8", "WBGene00021349", "P30644", "WBGene00011145", "P90994", "WBGene00015184", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "Q95XX0", "WBGene00006708", "O45495", "WBGene00006730", "Q95XX0", "WBGene00006708", "O45495", "WBGene00006730", "P90994", "WBGene00015184", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "Q19625", "WBGene00003412", "Q95QV2", "WBGene00000477", "H2L0N8", "WBGene00021349", "P30644", "WBGene00011145", "G5ED37", "WBGene00003885" ] }, "reaction_10572522": { "compartment": "compartment_70101", "id": "reaction_10572522", "reactome": "R-CEL-9641127", "name": "Ub:misfolded proteins polymerize to PolyUb:misfolded proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10572518" ], "products": [ "species_10572500" ], "modifiers": [], "additional_components": [ "Q95XX0", "WBGene00006708", "O45495", "WBGene00006730", "P90994", "WBGene00015184", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "Q19625", "WBGene00003412", "Q95QV2", "WBGene00000477", "H2L0N8", "WBGene00021349", "P30644", "WBGene00011145", "G5ED37", "WBGene00003885", "Q95XX0", "WBGene00006708", "O45495", "WBGene00006730", "P90994", "WBGene00015184", "H2L0N8", "WBGene00021349", "P30644", "WBGene00011145", "G5ED37", "WBGene00003885", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "Q19625", "WBGene00003412", "Q95QV2", "WBGene00000477" ] }, "reaction_10550384": { "compartment": "compartment_70101", "id": "reaction_10550384", "reactome": "R-CEL-5205649", "name": "p62 links damaged mitochondria to LC3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10550378", "species_10550373" ], "products": [ "species_10550382" ], "modifiers": [], "additional_components": [ "WBGene00002981", "Q23424", "WBGene00001509", "Q17746", "WBGene00015552", "Q18746", "WBGene00008236", "Q21752", "WBGene00019900", "Q23424", "WBGene00001509", "Q17746", "WBGene00015552", "Q18746", "WBGene00008236", "Q21752", "WBGene00019900", "Q23536", "WBGene00002981" ] }, "reaction_10550417": { "compartment": "compartment_17927", "id": "reaction_10550417", "reactome": "R-CEL-5205681", "name": "Pink1 is cleaved on healthy mitochondria", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10550393" ], "products": [ "species_10550415" ], "modifiers": [], "additional_components": [ "WBGene00017137", "WBGene00017137" ] }, "reaction_10550409": { "compartment": "compartment_21994", "id": "reaction_10550409", "reactome": "R-CEL-5205663", "name": "LC3 binds the autophagosome membrane Atg5-Atg12 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10550382", "species_10550405" ], "products": [ "species_10550407" ], "modifiers": [], "additional_components": [ "Q23424", "WBGene00001509", "Q17746", "WBGene00015552", "Q18746", "WBGene00008236", "Q21752", "WBGene00019900", "Q23536", "WBGene00002981", "Q3V5I7", "WBGene00022152", "Q10931", "WBGene00002982", "Q3V5I7", "WBGene00022152", "Q10931", "WBGene00002982", "Q23424", "WBGene00001509", "Q17746", "WBGene00015552", "Q18746", "WBGene00008236", "Q21752", "WBGene00019900", "Q23536", "WBGene00002981" ] }, "reaction_10550411": { "compartment": "compartment_17906", "id": "reaction_10550411", "reactome": "R-CEL-5205672", "name": "Uncleaved Pink1 accumulates in damaged mitochondria", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10550393" ], "products": [ "species_10550389" ], "modifiers": [], "additional_components": [ "WBGene00017137", "WBGene00017137" ] }, "reaction_10550413": { "compartment": "compartment_70101", "id": "reaction_10550413", "reactome": "R-CEL-5205673", "name": "p62 binds ubiquitinated mitochondrial substrates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10550366", "species_10550360", "species_10550371", "species_10550354", "species_10550352" ], "products": [ "species_10550373" ], "modifiers": [], "additional_components": [ "WBGene00019900", "WBGene00008236", "WBGene00015552", "WBGene00001509", "WBGene00001509", "Q23424", "WBGene00001509", "Q17746", "WBGene00015552", "Q18746", "WBGene00008236", "Q21752", "WBGene00019900" ] }, "reaction_10568834": { "compartment": "compartment_17906", "id": "reaction_10568834", "reactome": "R-CEL-8948146", "name": "FUNDC1 is phosphorylated by ULK1 at Ser17", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10568806" ], "products": [ "species_10568831", "species_29370" ], "modifiers": [ [ "species_10568813", "catalyst" ] ], "additional_components": [ "WBGene00011528", "WBGene00011528", "WBGene00006786" ] }, "reaction_10570165": { "compartment": "compartment_70101", "id": "reaction_10570165", "reactome": "R-CEL-8959573", "name": "Phosphorylated FUNDC1 links damaged mitochondria to LC3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10568831", "species_10550378" ], "products": [ "species_10570159" ], "modifiers": [], "additional_components": [ "WBGene00011528", "WBGene00002981", "Q23536", "WBGene00002981", "Q22252", "WBGene00011528" ] }, "reaction_10568823": { "compartment": "compartment_70101", "id": "reaction_10568823", "reactome": "R-CEL-8948139", "name": "p-S13-FUNDC1 is dephosphorylated by PGAM5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10568809" ], "products": [ "species_10568806" ], "modifiers": [ [ "species_10568820", "catalyst" ] ], "additional_components": [ "WBGene00011528", "WBGene00011528", "WBGene00019941" ] }, "reaction_10568811": { "compartment": "compartment_70101", "id": "reaction_10568811", "reactome": "R-CEL-8948039", "name": "FUNDC1 is phosphorylated by CK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10568806" ], "products": [ "species_29370", "species_10568809" ], "modifiers": [ [ "species_10515097", "catalyst" ] ], "additional_components": [ "WBGene00011528", "WBGene00011528", "P18334", "WBGene00002191", "P28548", "WBGene00002196" ] }, "reaction_10568828": { "compartment": "compartment_70101", "id": "reaction_10568828", "reactome": "R-CEL-8948143", "name": "p-S13, FUNDC1 is phosphorylated by CK2 at Tyr18", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10568809" ], "products": [ "species_10568826", "species_29370" ], "modifiers": [ [ "species_10513079", "catalyst" ] ], "additional_components": [ "WBGene00011528", "WBGene00011528", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635" ] }, "reaction_10568815": { "compartment": "compartment_17906", "id": "reaction_10568815", "reactome": "R-CEL-8948136", "name": "ULK1 Translocates to the mitochondria", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10554651" ], "products": [ "species_10568813" ], "modifiers": [], "additional_components": [ "WBGene00006786", "WBGene00006786" ] }, "reaction_10527767": { "compartment": "compartment_984", "id": "reaction_10527767", "reactome": "R-CEL-629588", "name": "Binding of acetylcholine to highly sodium permeable postsynaptic acetylcholine receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10527685", "species_372533" ], "products": [ "species_10527687" ], "modifiers": [], "additional_components": [ "G5EDF1", "WBGene00000051", "Q93329", "WBGene00002975", "O17274", "WBGene00020836", "Q9N4M3", "WBGene00000045", "P48181", "WBGene00006765", "Q9N587", "WBGene00006797", "P48182", "WBGene00000042", "Q23022", "WBGene00006774", "Q23355", "WBGene00000047", "Q27218", "WBGene00002974", "Q93149", "WBGene00000043", "H2KZY7", "WBGene00022283", "species_372533", "G5EDF1", "WBGene00000051", "Q93329", "WBGene00002975", "O17274", "WBGene00020836", "Q9N4M3", "WBGene00000045", "P48181", "WBGene00006765", "Q9N587", "WBGene00006797", "P48182", "WBGene00000042", "Q23022", "WBGene00006774", "Q23355", "WBGene00000047", "Q27218", "WBGene00002974", "Q93149", "WBGene00000043", "H2KZY7", "WBGene00022283" ] }, "reaction_10527690": { "compartment": "compartment_876", "id": "reaction_10527690", "reactome": "R-CEL-622325", "name": "Activation of highly sodium permeable postsynaptic nicotinic acetylcholine receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74113" ], "products": [ "species_83910" ], "modifiers": [ [ "species_10527687", "catalyst" ] ], "additional_components": [ "species_372533", "G5EDF1", "WBGene00000051", "Q93329", "WBGene00002975", "O17274", "WBGene00020836", "Q9N4M3", "WBGene00000045", "P48181", "WBGene00006765", "Q9N587", "WBGene00006797", "P48182", "WBGene00000042", "Q23022", "WBGene00006774", "Q23355", "WBGene00000047", "Q27218", "WBGene00002974", "Q93149", "WBGene00000043", "H2KZY7", "WBGene00022283" ] }, "reaction_10564113": { "compartment": "compartment_7660", "id": "reaction_10564113", "reactome": "R-CEL-6811522", "name": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6810408", "species_29358" ], "products": [ "species_113582", "species_6810412" ], "modifiers": [ [ "species_10564110", "catalyst" ] ], "additional_components": [ "Q9BL73", "WBGene00004088" ] }, "reaction_10563787": { "compartment": "compartment_172574", "id": "reaction_10563787", "reactome": "R-CEL-6810392", "name": "TMEM55B translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10563783" ], "products": [ "species_10563785" ], "modifiers": [], "additional_components": [ "WBGene00022167", "WBGene00022167" ] }, "reaction_10563790": { "compartment": "compartment_7660", "id": "reaction_10563790", "reactome": "R-CEL-6810410", "name": "PI(4,5)P2 is dephosphorylated to PI5P by TMEM55B in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_6810412" ], "products": [ "species_6810408", "species_113550" ], "modifiers": [ [ "species_10563785", "catalyst" ] ], "additional_components": [ "WBGene00022167" ] }, "reaction_10511490": { "compartment": "compartment_876", "id": "reaction_10511490", "reactome": "R-CEL-170986", "name": "Ral-GDS binds to Ras-GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10511486", "species_10511481" ], "products": [ "species_10511488" ], "modifiers": [], "additional_components": [ "WBGene00017891", "species_29438", "P22981", "WBGene00002335", "species_29438", "P22981", "WBGene00002335", "Q19852", "WBGene00017891" ] }, "reaction_10512661": { "compartment": "compartment_70101", "id": "reaction_10512661", "reactome": "R-CEL-187688", "name": "p38 MAPK phosphorylates MAPKAPK2, MAPKAPK3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10512628" ], "products": [ "species_29370", "species_10512646" ], "modifiers": [ [ "species_10512658", "catalyst" ] ], "additional_components": [ "Q21360", "WBGene00010681", "Q965G5", "WBGene00007007", "Q21360", "WBGene00010681", "Q965G5", "WBGene00007007", "Q17446", "WBGene00004055", "Q8MXI4", "WBGene00004056", "species_114632" ] }, "reaction_10572080": { "compartment": "compartment_70101", "id": "reaction_10572080", "reactome": "R-CEL-9610166", "name": "p-T,Y MAPK dimers translocate to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10542082" ], "products": [ "species_10514067" ], "modifiers": [], "additional_components": [ "P39745", "WBGene00003401", "P39745", "WBGene00003401" ] }, "reaction_10572066": { "compartment": "compartment_74700", "id": "reaction_10572066", "reactome": "R-CEL-9610153", "name": "Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10572055" ], "products": [ "species_10572059", "species_29370" ], "modifiers": [ [ "species_10572055", "catalyst" ] ], "additional_components": [ "Q10664", "WBGene00003186", "Q18246", "WBGene00004307", "species_29438", "species_216785", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "Q07292", "WBGene00003030", "P39745", "WBGene00003401", "Q18246", "WBGene00004307", "species_29438", "species_216785", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "Q07292", "WBGene00003030", "Q10664", "WBGene00003186", "P39745", "WBGene00003401", "Q10664", "WBGene00003186", "Q18246", "WBGene00004307", "species_29438", "species_216785", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "Q07292", "WBGene00003030", "P39745", "WBGene00003401" ] }, "reaction_10572070": { "compartment": "compartment_70101", "id": "reaction_10572070", "reactome": "R-CEL-9610154", "name": "Dissociation of phosphorylated MAP2Ks and MAPKs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10572068" ], "products": [ "species_10555065", "species_10508583", "species_10572053" ], "modifiers": [], "additional_components": [ "Q18246", "WBGene00004307", "species_29438", "species_216785", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "Q07292", "WBGene00003030", "P39745", "WBGene00003401", "Q10664", "WBGene00003186", "Q10664", "WBGene00003186", "WBGene00003401", "Q18246", "WBGene00004307", "species_29438", "species_216785", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "Q07292", "WBGene00003030" ] }, "reaction_10572057": { "compartment": "compartment_74700", "id": "reaction_10572057", "reactome": "R-CEL-9610152", "name": "Activated BRAF recruits MAP2Ks and MAPKs to the endosome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508575", "species_10572053", "species_10555040" ], "products": [ "species_10572055" ], "modifiers": [], "additional_components": [ "WBGene00003401", "Q18246", "WBGene00004307", "species_29438", "species_216785", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "Q07292", "WBGene00003030", "Q10664", "WBGene00003186", "Q10664", "WBGene00003186", "Q18246", "WBGene00004307", "species_29438", "species_216785", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "Q07292", "WBGene00003030", "P39745", "WBGene00003401" ] }, "reaction_10572073": { "compartment": "compartment_70101", "id": "reaction_10572073", "reactome": "R-CEL-9610156", "name": "MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10572059", "species_113592" ], "products": [ "species_29370", "species_10572068" ], "modifiers": [ [ "species_10572059", "catalyst" ] ], "additional_components": [ "Q18246", "WBGene00004307", "species_29438", "species_216785", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "Q07292", "WBGene00003030", "Q10664", "WBGene00003186", "P39745", "WBGene00003401", "Q18246", "WBGene00004307", "species_29438", "species_216785", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "Q07292", "WBGene00003030", "P39745", "WBGene00003401", "Q10664", "WBGene00003186", "Q18246", "WBGene00004307", "species_29438", "species_216785", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "Q07292", "WBGene00003030", "Q10664", "WBGene00003186", "P39745", "WBGene00003401" ] }, "reaction_10555163": { "compartment": "compartment_70101", "id": "reaction_10555163", "reactome": "R-CEL-5674385", "name": "p-T,Y MAPKs dimerize", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508583" ], "products": [ "species_10542082" ], "modifiers": [], "additional_components": [ "WBGene00003401", "P39745", "WBGene00003401" ] }, "reaction_10572078": { "compartment": "compartment_74700", "id": "reaction_10572078", "reactome": "R-CEL-9610163", "name": "BRAF autophosphorylates downstream of RAP1 and NGF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10572075", "species_113592" ], "products": [ "species_29370", "species_10572053" ], "modifiers": [ [ "species_10572075", "catalyst" ] ], "additional_components": [ "Q18246", "WBGene00004307", "species_216785", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "Q07292", "WBGene00003030", "species_29438", "Q18246", "WBGene00004307", "species_29438", "species_216785", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "Q07292", "WBGene00003030", "Q18246", "WBGene00004307", "species_216785", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "Q07292", "WBGene00003030", "species_29438" ] }, "reaction_10572117": { "compartment": "compartment_7660", "id": "reaction_10572117", "reactome": "R-CEL-9612509", "name": "SGK phosphorylates SRF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10572112" ], "products": [ "species_113582", "species_10572115" ], "modifiers": [ [ "species_10572104", "catalyst" ] ], "additional_components": [ "WBGene00006844", "WBGene00006844", "WBGene00004789" ] }, "reaction_10572132": { "compartment": "compartment_7660", "id": "reaction_10572132", "reactome": "R-CEL-9613213", "name": "NAB2 and CHD4 bind and repress EGR-mediated RRAD gene expression", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10572122", "species_10547994", "species_10572128" ], "products": [ "species_10572130" ], "modifiers": [], "additional_components": [ "WBGene00003107", "G5EBZ4", "WBGene00002637", "Q22516", "WBGene00000482", "Q18250", "WBGene00007772", "G5EBZ4", "WBGene00002637", "Q22516", "WBGene00000482", "Q22002", "WBGene00003107", "Q18250", "WBGene00007772" ] }, "reaction_10572107": { "compartment": "compartment_7660", "id": "reaction_10572107", "reactome": "R-CEL-9612501", "name": "SGK phosphorylates CREB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10514243" ], "products": [ "species_113582", "species_10514246" ], "modifiers": [ [ "species_10572104", "catalyst" ] ], "additional_components": [ "WBGene00000793", "WBGene00000793", "WBGene00004789" ] }, "reaction_10514065": { "compartment": "compartment_7660", "id": "reaction_10514065", "reactome": "R-CEL-198746", "name": "ERK1/2/5 activate RSK1/2/3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10514008" ], "products": [ "species_113582", "species_10514054" ], "modifiers": [ [ "species_10514062", "catalyst" ] ], "additional_components": [ "Q19858", "WBGene00017898", "Q21734", "WBGene00011352", "Q21734", "WBGene00011352", "Q19858", "WBGene00017898", "P39745", "WBGene00003401", "H2KYF8", "WBGene00003402" ] }, "reaction_10514435": { "compartment": "compartment_7660", "id": "reaction_10514435", "reactome": "R-CEL-199959", "name": "ERKs are inactivated by protein phosphatase 2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10514062" ], "products": [ "species_113550", "species_10514418" ], "modifiers": [ [ "species_10514432", "catalyst" ] ], "additional_components": [ "P39745", "WBGene00003401", "H2KYF8", "WBGene00003402", "H2KYF8", "WBGene00003402", "P39745", "WBGene00003401", "A9UJN4", "WBGene00007554" ] }, "reaction_10514070": { "compartment": "compartment_7660", "id": "reaction_10514070", "reactome": "R-CEL-198756", "name": "ERK1/2 phosphorylates MSK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10513966" ], "products": [ "species_113582", "species_10513972" ], "modifiers": [ [ "species_10514067", "catalyst" ] ], "additional_components": [ "WBGene00008311", "WBGene00008311", "P39745", "WBGene00003401" ] }, "reaction_10513975": { "compartment": "compartment_7660", "id": "reaction_10513975", "reactome": "R-CEL-198669", "name": "p38MAPK phosphorylates MSK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10513966" ], "products": [ "species_113582", "species_10513972" ], "modifiers": [ [ "species_10510865", "catalyst" ] ], "additional_components": [ "WBGene00008311", "WBGene00008311", "Q17446", "WBGene00004055", "Q8MXI4", "WBGene00004056" ] }, "reaction_10515399": { "compartment": "compartment_7660", "id": "reaction_10515399", "reactome": "R-CEL-203797", "name": "ERKs are inactivated by dual-specific phosphatases (DUSPs)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10514062" ], "products": [ "species_113550", "species_10514418" ], "modifiers": [ [ "species_10515396", "catalyst" ] ], "additional_components": [ "P39745", "WBGene00003401", "H2KYF8", "WBGene00003402", "H2KYF8", "WBGene00003402", "P39745", "WBGene00003401", "Q9XUJ0", "WBGene00012372" ] }, "reaction_10514385": { "compartment": "compartment_7660", "id": "reaction_10514385", "reactome": "R-CEL-199895", "name": "RSK1/2/3 phosphorylates CREB at Serine 133", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10514243" ], "products": [ "species_113582", "species_10514246" ], "modifiers": [ [ "species_10514054", "catalyst" ] ], "additional_components": [ "WBGene00000793", "WBGene00000793", "Q21734", "WBGene00011352", "Q19858", "WBGene00017898" ] }, "reaction_10514402": { "compartment": "compartment_7660", "id": "reaction_10514402", "reactome": "R-CEL-199917", "name": "MAPKAPK2 phosphorylates CREB at Serine 133", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10514243" ], "products": [ "species_113582", "species_10514246" ], "modifiers": [ [ "species_10514399", "catalyst" ] ], "additional_components": [ "WBGene00000793", "WBGene00000793", "Q21360", "WBGene00010681", "Q965G5", "WBGene00007007" ] }, "reaction_10514404": { "compartment": "compartment_7660", "id": "reaction_10514404", "reactome": "R-CEL-199935", "name": "MSK1 activates CREB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10514243" ], "products": [ "species_113582", "species_10514246" ], "modifiers": [ [ "species_10513972", "catalyst" ] ], "additional_components": [ "WBGene00000793", "WBGene00000793", "WBGene00008311" ] }, "reaction_10514393": { "compartment": "compartment_7660", "id": "reaction_10514393", "reactome": "R-CEL-199910", "name": "MSK1 activates ATF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10514387" ], "products": [ "species_113582", "species_10514390" ], "modifiers": [ [ "species_10513972", "catalyst" ] ], "additional_components": [ "WBGene00000793", "WBGene00000793", "WBGene00008311" ] }, "reaction_10513986": { "compartment": "compartment_7660", "id": "reaction_10513986", "reactome": "R-CEL-198714", "name": "ERK5 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10513982" ], "products": [ "species_10513984" ], "modifiers": [], "additional_components": [ "WBGene00003402", "WBGene00003402" ] }, "reaction_10515269": { "compartment": "compartment_876", "id": "reaction_10515269", "reactome": "R-CEL-202692", "name": "PIP3 binds to RhoA and activates it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509484", "species_179838" ], "products": [ "species_10515267" ], "modifiers": [], "additional_components": [ "WBGene00004357", "Q22038", "WBGene00004357", "species_179838" ] }, "reaction_10545459": { "compartment": "compartment_876", "id": "reaction_10545459", "reactome": "R-CEL-2684507", "name": "Syndecans 1, 2, 4, (3) bind FGF2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10512869", "species_10541682" ], "products": [ "species_10545457" ], "modifiers": [], "additional_components": [ "WBGene00002881", "WBGene00004749", "P50605", "WBGene00004749", "Q11184", "WBGene00002881" ] }, "reaction_10545556": { "compartment": "compartment_876", "id": "reaction_10545556", "reactome": "R-CEL-2731074", "name": "Syndecan-1 binds Integrins alpha2beta1, (alpha6beta4)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10541682", "species_10545552" ], "products": [ "species_10545554" ], "modifiers": [], "additional_components": [ "WBGene00004749", "P34446", "WBGene00003929", "Q27874", "WBGene00003930", "P34446", "WBGene00003929", "Q27874", "WBGene00003930", "P50605", "WBGene00004749" ] }, "reaction_10545560": { "compartment": "compartment_876", "id": "reaction_10545560", "reactome": "R-CEL-2731078", "name": "Syndecans 2, (4) bind TGFB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10511429", "species_10541684" ], "products": [ "species_10545558" ], "modifiers": [], "additional_components": [ "G5EBY8", "WBGene00006852", "G5EEL5", "WBGene00000936", "WBGene00004749", "P50605", "WBGene00004749", "G5EBY8", "WBGene00006852", "G5EEL5", "WBGene00000936" ] }, "reaction_10545913": { "compartment": "compartment_876", "id": "reaction_10545913", "reactome": "R-CEL-2750187", "name": "Syndecan-4:PI(4,5)P2 binds PKC alpha:DAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10545909", "species_10521475" ], "products": [ "species_10545911" ], "modifiers": [], "additional_components": [ "species_179856", "P50605", "WBGene00004749", "P90980", "WBGene00004033", "species_114519", "P90980", "WBGene00004033", "species_114519", "species_179856", "P50605", "WBGene00004749" ] }, "reaction_10545564": { "compartment": "compartment_876", "id": "reaction_10545564", "reactome": "R-CEL-2731141", "name": "Syndecan-1 binds fibronectin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10541682", "species_10517394" ], "products": [ "species_10545562" ], "modifiers": [], "additional_components": [ "WBGene00004749", "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769", "P50605", "WBGene00004749" ] }, "reaction_10546406": { "compartment": "compartment_70101", "id": "reaction_10546406", "reactome": "R-CEL-3134954", "name": "DHX9 binds DNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_3134861", "species_10546400" ], "products": [ "species_10546402" ], "modifiers": [], "additional_components": [ "WBGene00004355", "Q22307", "WBGene00004355" ] }, "reaction_10546408": { "compartment": "compartment_70101", "id": "reaction_10546408", "reactome": "R-CEL-3134962", "name": "DHX36 binds DNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546396", "species_3134861" ], "products": [ "species_10546398" ], "modifiers": [], "additional_components": [ "WBGene00009922", "Q20644", "WBGene00009922" ] }, "reaction_10527102": { "compartment": "compartment_984", "id": "reaction_10527102", "reactome": "R-CEL-500708", "name": "GRIK3 homomer binds glutamate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_210382", "species_10526044" ], "products": [ "species_10527100" ], "modifiers": [], "additional_components": [ "A0A1T5HUM0", "WBGene00001618", "O01623", "WBGene00001616", "Q17697", "WBGene00001615", "species_2730999", "A0A1T5HUM0", "WBGene00001618", "O01623", "WBGene00001616", "Q17697", "WBGene00001615", "species_2730999", "species_113552" ] }, "reaction_10526120": { "compartment": "compartment_984", "id": "reaction_10526120", "reactome": "R-CEL-451309", "name": "Edited Kainate Receptor binds glutamate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_210382", "species_10526116" ], "products": [ "species_10526118" ], "modifiers": [], "additional_components": [ "A0A1T5HUM0", "WBGene00001618", "O01623", "WBGene00001616", "Q17697", "WBGene00001615", "species_2730999", "A0A1T5HUM0", "WBGene00001618", "O01623", "WBGene00001616", "Q17697", "WBGene00001615", "species_2730999", "species_113552" ] }, "reaction_10526123": { "compartment": "compartment_984", "id": "reaction_10526123", "reactome": "R-CEL-451310", "name": "Activation of Edited Kainate receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74113" ], "products": [ "species_83910" ], "modifiers": [ [ "species_10526118", "catalyst" ] ], "additional_components": [ "A0A1T5HUM0", "WBGene00001618", "O01623", "WBGene00001616", "Q17697", "WBGene00001615", "species_2730999", "species_113552" ] }, "reaction_10526080": { "compartment": "compartment_876", "id": "reaction_10526080", "reactome": "R-CEL-451283", "name": "kainate receptor binds glutamate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_210382", "species_10526076" ], "products": [ "species_10526078" ], "modifiers": [], "additional_components": [ "G5ECY0", "WBGene00001006", "Q22638", "WBGene00011890", "P36609", "WBGene00003564", "Q11083", "WBGene00020378", "P04630", "WBGene00000285", "G5EF37", "WBGene00003934", "A0A2C9C3L3", "WBGene00020378", "Q18136", "WBGene00006861", "Q09665", "WBGene00006583", "O02159", "WBGene00020378", "G5EDZ8", "WBGene00000288", "Q94288", "WBGene00000287", "Q09980", "WBGene00017394", "O16305", "WBGene00000552", "G5EEG0", "WBGene00000286", "O01623", "WBGene00001616", "Q17697", "WBGene00001615", "A0A1T5HUM0", "WBGene00001618", "species_2730999", "G5ECY0", "WBGene00001006", "Q22638", "WBGene00011890", "P36609", "WBGene00003564", "Q11083", "WBGene00020378", "P04630", "WBGene00000285", "G5EF37", "WBGene00003934", "A0A2C9C3L3", "WBGene00020378", "Q18136", "WBGene00006861", "Q09665", "WBGene00006583", "O02159", "WBGene00020378", "G5EDZ8", "WBGene00000288", "Q94288", "WBGene00000287", "Q09980", "WBGene00017394", "O16305", "WBGene00000552", "G5EEG0", "WBGene00000286", "O01623", "WBGene00001616", "Q17697", "WBGene00001615", "A0A1T5HUM0", "WBGene00001618", "species_2730999", "species_113552" ] }, "reaction_10526126": { "compartment": "compartment_70101", "id": "reaction_10526126", "reactome": "R-CEL-451311", "name": "Activation of Ca-permeable Kainate receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74112" ], "products": [ "species_74016" ], "modifiers": [ [ "species_10526078", "catalyst" ] ], "additional_components": [ "G5ECY0", "WBGene00001006", "Q22638", "WBGene00011890", "P36609", "WBGene00003564", "Q11083", "WBGene00020378", "P04630", "WBGene00000285", "G5EF37", "WBGene00003934", "A0A2C9C3L3", "WBGene00020378", "Q18136", "WBGene00006861", "Q09665", "WBGene00006583", "O02159", "WBGene00020378", "G5EDZ8", "WBGene00000288", "Q94288", "WBGene00000287", "Q09980", "WBGene00017394", "O16305", "WBGene00000552", "G5EEG0", "WBGene00000286", "O01623", "WBGene00001616", "Q17697", "WBGene00001615", "A0A1T5HUM0", "WBGene00001618", "species_2730999", "species_113552" ] }, "reaction_10526193": { "compartment": "compartment_5460", "id": "reaction_10526193", "reactome": "R-CEL-452036", "name": "arginine + H2O => ornithine + urea [ARG2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_374064", "species_113521" ], "products": [ "species_374061", "species_113585" ], "modifiers": [ [ "species_10526190", "catalyst" ] ], "additional_components": [ "species_266099", "A0A1X7RC97", "WBGene00020658" ] }, "reaction_10503273": { "compartment": "compartment_70101", "id": "reaction_10503273", "reactome": "R-CEL-70634", "name": "ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113567", "species_29498" ], "products": [ "species_113585", "species_29968" ], "modifiers": [ [ "species_10503270", "catalyst" ] ], "additional_components": [ "WBGene00020422" ] }, "reaction_10503167": { "compartment": "compartment_70101", "id": "reaction_10503167", "reactome": "R-CEL-70569", "name": "arginine + H2O => ornithine + urea [ARG1]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_29468" ], "products": [ "species_29514", "species_29498" ], "modifiers": [ [ "species_10503164", "catalyst" ] ], "additional_components": [ "A0A1X7RC97", "WBGene00020658", "species_266099" ] }, "reaction_10525558": { "compartment": "compartment_7660", "id": "reaction_10525558", "reactome": "R-CEL-450333", "name": "Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10525555" ], "products": [ "species_113582", "species_10525449" ], "modifiers": [ [ "species_10525533", "catalyst" ] ], "additional_components": [ "Q17446", "WBGene00004055", "Q8MXI4", "WBGene00004056", "Q965G5", "WBGene00007007", "Q21360", "WBGene00010681", "Q17446", "WBGene00004055", "Q8MXI4", "WBGene00004056", "Q965G5", "WBGene00007007", "Q21360", "WBGene00010681", "G5EDF7", "WBGene00004758", "Q58AU7", "WBGene00018034", "Q58AU8", "WBGene00018035" ] }, "reaction_10525464": { "compartment": "compartment_7660", "id": "reaction_10525464", "reactome": "R-CEL-450222", "name": "Active p38 MAPK phosphorylates MAPKAPK2 or 3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10525449" ], "products": [ "species_113582", "species_10525461" ], "modifiers": [ [ "species_10525449", "catalyst" ] ], "additional_components": [ "Q17446", "WBGene00004055", "Q8MXI4", "WBGene00004056", "Q965G5", "WBGene00007007", "Q21360", "WBGene00010681", "Q17446", "WBGene00004055", "Q8MXI4", "WBGene00004056", "Q965G5", "WBGene00007007", "Q21360", "WBGene00010681", "Q17446", "WBGene00004055", "Q8MXI4", "WBGene00004056", "Q965G5", "WBGene00007007", "Q21360", "WBGene00010681" ] }, "reaction_10525468": { "compartment": "compartment_70101", "id": "reaction_10525468", "reactome": "R-CEL-450257", "name": "Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10525461" ], "products": [ "species_10525466" ], "modifiers": [], "additional_components": [ "Q17446", "WBGene00004055", "Q8MXI4", "WBGene00004056", "Q965G5", "WBGene00007007", "Q21360", "WBGene00010681", "Q17446", "WBGene00004055", "Q8MXI4", "WBGene00004056", "Q21360", "WBGene00010681", "Q965G5", "WBGene00007007" ] }, "reaction_10525535": { "compartment": "compartment_70101", "id": "reaction_10525535", "reactome": "R-CEL-450296", "name": "Phosphorylated MKK3/MKK6 migrates to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10525521" ], "products": [ "species_10525533" ], "modifiers": [], "additional_components": [ "Q58AU7", "WBGene00018034", "Q58AU8", "WBGene00018035", "G5EDF7", "WBGene00004758", "G5EDF7", "WBGene00004758", "Q58AU7", "WBGene00018034", "Q58AU8", "WBGene00018035" ] }, "reaction_10525578": { "compartment": "compartment_70101", "id": "reaction_10525578", "reactome": "R-CEL-450348", "name": "Activated human JNKs migrate to nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10510969" ], "products": [ "species_10510908" ], "modifiers": [], "additional_components": [ "Q8WQG9", "WBGene00002178", "H2KZI0", "WBGene00002188", "O44408", "WBGene00002187", "Q8WQG9", "WBGene00002178", "H2KZI0", "WBGene00002188", "O44408", "WBGene00002187" ] }, "reaction_10510988": { "compartment": "compartment_70101", "id": "reaction_10510988", "reactome": "R-CEL-168162", "name": "Phosphorylation of human JNKs by activated MKK4/MKK7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10510949" ], "products": [ "species_29370", "species_10510969" ], "modifiers": [ [ "species_10510985", "catalyst" ] ], "additional_components": [ "Q8WQG9", "WBGene00002178", "H2KZI0", "WBGene00002188", "O44408", "WBGene00002187", "Q8WQG9", "WBGene00002178", "H2KZI0", "WBGene00002188", "O44408", "WBGene00002187", "Q21307", "WBGene00003185", "Q20347", "WBGene00003368" ] }, "reaction_10510992": { "compartment": "compartment_7660", "id": "reaction_10510992", "reactome": "R-CEL-168440", "name": "Formation of Activated Protein 1 (AP-1) complex. ATF2/c-JUN heterodimer. ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10510926", "species_10510845" ], "products": [ "species_10510990" ], "modifiers": [], "additional_components": [ "WBGene00012005", "WBGene00000223", "Q86MD3", "WBGene00000223", "G5ECU7", "WBGene00012005" ] }, "reaction_10510929": { "compartment": "compartment_7660", "id": "reaction_10510929", "reactome": "R-CEL-168136", "name": "Activated JNKs phosphorylate c-JUN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10510922" ], "products": [ "species_113582", "species_10510926" ], "modifiers": [ [ "species_10510908", "catalyst" ] ], "additional_components": [ "WBGene00012005", "WBGene00012005", "Q8WQG9", "WBGene00002178", "H2KZI0", "WBGene00002188", "O44408", "WBGene00002187" ] }, "reaction_10525492": { "compartment": "compartment_7660", "id": "reaction_10525492", "reactome": "R-CEL-450292", "name": "Formation of Activated Protein 1 (AP-1) complex. cFOS/c-JUN heterodimer. ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10510926", "species_10525488" ], "products": [ "species_10525490" ], "modifiers": [], "additional_components": [ "WBGene00012005", "G5ECG2", "WBGene00001345", "Q9N5A8", "WBGene00021082", "G5ECG2", "WBGene00001345", "Q9N5A8", "WBGene00021082", "G5ECU7", "WBGene00012005" ] }, "reaction_10510917": { "compartment": "compartment_7660", "id": "reaction_10510917", "reactome": "R-CEL-168053", "name": "Phosphorylated MAPKs phosphorylate ATF-2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10510841" ], "products": [ "species_113582", "species_10510845" ], "modifiers": [ [ "species_10510914", "catalyst" ] ], "additional_components": [ "WBGene00000223", "WBGene00000223", "Q17446", "WBGene00004055", "Q8MXI4", "WBGene00004056", "Q8WQG9", "WBGene00002178", "H2KZI0", "WBGene00002188", "O44408", "WBGene00002187" ] }, "reaction_10525543": { "compartment": "compartment_7660", "id": "reaction_10525543", "reactome": "R-CEL-450325", "name": "c-FOS activation by phospho ERK1/2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10525541" ], "products": [ "species_113582", "species_10525488" ], "modifiers": [ [ "species_10514067", "catalyst" ] ], "additional_components": [ "G5ECG2", "WBGene00001345", "Q9N5A8", "WBGene00021082", "G5ECG2", "WBGene00001345", "Q9N5A8", "WBGene00021082", "P39745", "WBGene00003401" ] }, "reaction_10528549": { "compartment": "compartment_13231", "id": "reaction_10528549", "reactome": "R-CEL-913529", "name": "Translocation of p-STAT1:p-STAT1 dimer to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10528455" ], "products": [ "species_10528543" ], "modifiers": [ [ "species_10528547", "catalyst" ] ], "additional_components": [ "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q22560", "WBGene00002072", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q9BIB8", "WBGene00002075" ] }, "reaction_10537425": { "compartment": "compartment_70101", "id": "reaction_10537425", "reactome": "R-CEL-1678843", "name": "ISGylation of protein translation regulator 4EHP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10537411", "species_10531955" ], "products": [ "species_10537413" ], "modifiers": [], "additional_components": [ "WBGene00002062", "Q9BL11", "WBGene00021685", "O01965", "WBGene00016158", "P91057", "WBGene00015842", "Q21633", "WBGene00006713", "Q22888", "WBGene00002062", "Q9BL11", "WBGene00021685", "O01965", "WBGene00016158", "P91057", "WBGene00015842", "Q21633", "WBGene00006713" ] }, "reaction_10531986": { "compartment": "compartment_70101", "id": "reaction_10531986", "reactome": "R-CEL-1169404", "name": "Transfer of ISG15 from E1 to E2 (UBCH8)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10529367", "species_10531957" ], "products": [ "species_10529372", "species_10531946" ], "modifiers": [ [ "species_10529367", "catalyst" ] ], "additional_components": [ "WBGene00006713", "P91057", "WBGene00015842", "Q27481", "WBGene00006699", "WBGene00006699", "P91057", "WBGene00015842", "Q21633", "WBGene00006713", "WBGene00006713" ] }, "reaction_10531971": { "compartment": "compartment_70101", "id": "reaction_10531971", "reactome": "R-CEL-1169398", "name": "ISGylation of host protein filamin B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10531966", "species_113592", "species_10531955" ], "products": [ "species_111294", "species_10529367", "species_10531953", "species_76577", "species_10531968" ], "modifiers": [ [ "species_10531955", "catalyst" ] ], "additional_components": [ "D0VWL6", "WBGene00016006", "U4PBJ9", "WBGene00022048", "Q9BL11", "WBGene00021685", "O01965", "WBGene00016158", "P91057", "WBGene00015842", "Q21633", "WBGene00006713", "WBGene00006713", "Q9BL11", "WBGene00021685", "O01965", "WBGene00016158", "P91057", "WBGene00015842", "D0VWL6", "WBGene00016006", "U4PBJ9", "WBGene00022048", "Q9BL11", "WBGene00021685", "O01965", "WBGene00016158", "P91057", "WBGene00015842", "Q21633", "WBGene00006713" ] }, "reaction_10531975": { "compartment": "compartment_70101", "id": "reaction_10531975", "reactome": "R-CEL-1169399", "name": "Interaction of ISG15 with NEDD4 and inhibition of Ebola virus budding", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10530876", "species_10529362" ], "products": [ "species_10531973" ], "modifiers": [], "additional_components": [ "WBGene00022358", "WBGene00015842", "P91057", "WBGene00015842", "A0A061ACQ8", "WBGene00022358" ] }, "reaction_10531960": { "compartment": "compartment_70101", "id": "reaction_10531960", "reactome": "R-CEL-1169397", "name": "Activation of ISG15 by UBA7 E1 ligase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10529372", "species_113592", "species_10529362" ], "products": [ "species_111294", "species_10531957", "species_76577" ], "modifiers": [ [ "species_10529372", "catalyst" ] ], "additional_components": [ "WBGene00006699", "WBGene00015842", "P91057", "WBGene00015842", "Q27481", "WBGene00006699", "WBGene00006699" ] }, "reaction_10531992": { "compartment": "compartment_70101", "id": "reaction_10531992", "reactome": "R-CEL-1169405", "name": "ISGylation of protein phosphatase 1 beta (PP2CB)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10531988", "species_10531955" ], "products": [ "species_111294", "species_10529367", "species_10531990", "species_10531953", "species_76577" ], "modifiers": [ [ "species_10531955", "catalyst" ] ], "additional_components": [ "WBGene00006460", "Q9BL11", "WBGene00021685", "O01965", "WBGene00016158", "P91057", "WBGene00015842", "Q21633", "WBGene00006713", "WBGene00006713", "P91057", "WBGene00015842", "Q19775", "WBGene00006460", "Q9BL11", "WBGene00021685", "O01965", "WBGene00016158", "Q9BL11", "WBGene00021685", "O01965", "WBGene00016158", "P91057", "WBGene00015842", "Q21633", "WBGene00006713" ] }, "reaction_10532011": { "compartment": "compartment_70101", "id": "reaction_10532011", "reactome": "R-CEL-1169406", "name": "ISGylation of host proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10532007", "species_10531955" ], "products": [ "species_111294", "species_10532009", "species_10529367", "species_10531953", "species_76577" ], "modifiers": [ [ "species_10531955", "catalyst" ] ], "additional_components": [ "P39745", "WBGene00003401", "H8W3X5", "WBGene00219376", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q22070", "WBGene00004038", "Q9BL11", "WBGene00021685", "O01965", "WBGene00016158", "P91057", "WBGene00015842", "Q21633", "WBGene00006713", "P91057", "WBGene00015842", "P39745", "WBGene00003401", "H8W3X5", "WBGene00219376", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q22070", "WBGene00004038", "WBGene00006713", "Q9BL11", "WBGene00021685", "O01965", "WBGene00016158", "Q9BL11", "WBGene00021685", "O01965", "WBGene00016158", "P91057", "WBGene00015842", "Q21633", "WBGene00006713" ] }, "reaction_10531981": { "compartment": "compartment_70101", "id": "reaction_10531981", "reactome": "R-CEL-1169402", "name": "ISGylation of E2 conjugating enzymes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10531977", "species_10531955" ], "products": [ "species_111294", "species_10531979", "species_10529367", "species_10531953", "species_76577" ], "modifiers": [ [ "species_10531955", "catalyst" ] ], "additional_components": [ "Q95XX0", "WBGene00006708", "H8W3X5", "WBGene00219376", "Q9BL11", "WBGene00021685", "O01965", "WBGene00016158", "P91057", "WBGene00015842", "Q21633", "WBGene00006713", "P91057", "WBGene00015842", "Q95XX0", "WBGene00006708", "H8W3X5", "WBGene00219376", "WBGene00006713", "Q9BL11", "WBGene00021685", "O01965", "WBGene00016158", "Q9BL11", "WBGene00021685", "O01965", "WBGene00016158", "P91057", "WBGene00015842", "Q21633", "WBGene00006713" ] }, "reaction_10537406": { "compartment": "compartment_70101", "id": "reaction_10537406", "reactome": "R-CEL-1678841", "name": "Regulation of protein ISGylation by ISG15 deconjugating enzyme USP18", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10532009" ], "products": [ "species_10532007", "species_141681" ], "modifiers": [ [ "species_10537403", "catalyst" ] ], "additional_components": [ "P91057", "WBGene00015842", "P39745", "WBGene00003401", "H8W3X5", "WBGene00219376", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q22070", "WBGene00004038", "P39745", "WBGene00003401", "H8W3X5", "WBGene00219376", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q22070", "WBGene00004038", "H2L010", "WBGene00020695" ] }, "reaction_10531983": { "compartment": "compartment_70101", "id": "reaction_10531983", "reactome": "R-CEL-1169403", "name": "Interaction of E3 ligase with ISG15:E2 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10531946", "species_10531953" ], "products": [ "species_10531955" ], "modifiers": [], "additional_components": [ "P91057", "WBGene00015842", "Q21633", "WBGene00006713", "Q9BL11", "WBGene00021685", "O01965", "WBGene00016158", "Q9BL11", "WBGene00021685", "O01965", "WBGene00016158", "P91057", "WBGene00015842", "Q21633", "WBGene00006713" ] }, "reaction_10537423": { "compartment": "compartment_70101", "id": "reaction_10537423", "reactome": "R-CEL-1678842", "name": "Competitive inhibition of translation initiation by ISGylated 4EHP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10537419", "species_10537413" ], "products": [ "species_10537421", "species_10537417" ], "modifiers": [], "additional_components": [ "Q20935", "WBGene00018997", "P27639", "WBGene00002083", "Q9BL61", "WBGene00022029", "A0A486WX07", "WBGene00002066", "O61955", "WBGene00002061", "Q22888", "WBGene00002062", "Q9BL11", "WBGene00021685", "O01965", "WBGene00016158", "P91057", "WBGene00015842", "Q21633", "WBGene00006713", "Q22888", "WBGene00002062", "Q9BL11", "WBGene00021685", "O01965", "WBGene00016158", "P91057", "WBGene00015842", "Q21633", "WBGene00006713", "Q20935", "WBGene00018997", "P27639", "WBGene00002083", "Q9BL61", "WBGene00022029", "A0A486WX07", "WBGene00002066", "O61955", "WBGene00002061" ] }, "reaction_10570813": { "compartment": "compartment_70101", "id": "reaction_10570813", "reactome": "R-CEL-9009950", "name": "PDE12 cleaves 2'-5' oligoadenylates ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_8983696" ], "products": [ "species_70106", "species_113592", "species_76577" ], "modifiers": [ [ "species_10570810", "catalyst" ] ], "additional_components": [ "species_29358", "WBGene00011268" ] }, "reaction_10528100": { "compartment": "compartment_7660", "id": "reaction_10528100", "reactome": "R-CEL-877281", "name": "PIAS1 binds p-STAT1 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10528077", "species_10528091", "species_10528096" ], "products": [ "species_10528098" ], "modifiers": [], "additional_components": [ "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q21970", "WBGene00011259", "Q94361", "WBGene00001574", "WBGene00004888", "P55853", "WBGene00004888", "Q21970", "WBGene00011259", "Q94361", "WBGene00001574", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111" ] }, "reaction_10528079": { "compartment": "compartment_13231", "id": "reaction_10528079", "reactome": "R-CEL-873917", "name": "Translocation of STAT1 dimer to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10528069" ], "products": [ "species_10528077" ], "modifiers": [], "additional_components": [ "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111" ] }, "reaction_10554345": { "compartment": "compartment_876", "id": "reaction_10554345", "reactome": "R-CEL-5654511", "name": "FGFRL1 dimer binds FGFs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10554341", "species_10554339", "species_190915" ], "products": [ "species_10554343" ], "modifiers": [], "additional_components": [ "G5EEF1", "WBGene00001185", "Q95XJ7", "WBGene00022418", "species_190915", "Q95XJ7", "WBGene00022418", "G5EEF1", "WBGene00001185" ] }, "reaction_10554354": { "compartment": "compartment_984", "id": "reaction_10554354", "reactome": "R-CEL-5654515", "name": "KAL1 binds HS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10554350", "species_190915" ], "products": [ "species_10554352" ], "modifiers": [], "additional_components": [ "WBGene00002181", "species_190915", "G5EDX1", "WBGene00002181" ] }, "reaction_10554370": { "compartment": "compartment_70101", "id": "reaction_10554370", "reactome": "R-CEL-5654690", "name": "FGFR1-associated PI3K phosphorylates PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10543825", "catalyst" ] ], "additional_components": [ "Q94125", "WBGene00000090", "G5EDP9", "WBGene00000001", "P29355", "WBGene00004774", "G5EDJ4", "WBGene00004928", "E6N0V1", "WBGene00018819" ] }, "reaction_10512173": { "compartment": "compartment_70101", "id": "reaction_10512173", "reactome": "R-CEL-177931", "name": "Binding of PIK3 regulatory alpha subunit to GRB2:GAB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10512121", "species_10506883" ], "products": [ "species_10512171" ], "modifiers": [], "additional_components": [ "P29355", "WBGene00004774", "G5EDJ4", "WBGene00004928", "WBGene00000001", "G5EDP9", "WBGene00000001", "P29355", "WBGene00004774", "G5EDJ4", "WBGene00004928" ] }, "reaction_10554373": { "compartment": "compartment_70101", "id": "reaction_10554373", "reactome": "R-CEL-5654697", "name": "FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10543855", "catalyst" ] ], "additional_components": [ "Q94125", "WBGene00000090", "G5EDP9", "WBGene00000001", "P29355", "WBGene00004774", "G5EDJ4", "WBGene00004928", "E6N0V1", "WBGene00018819" ] }, "reaction_10554358": { "compartment": "compartment_70101", "id": "reaction_10554358", "reactome": "R-CEL-5654614", "name": "Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10506890", "species_10543831" ], "products": [ "species_10543833" ], "modifiers": [], "additional_components": [ "WBGene00000090", "E6N0V1", "WBGene00018819", "G5EDP9", "WBGene00000001", "P29355", "WBGene00004774", "G5EDJ4", "WBGene00004928", "E6N0V1", "WBGene00018819", "G5EDP9", "WBGene00000001", "P29355", "WBGene00004774", "G5EDJ4", "WBGene00004928", "Q94125", "WBGene00000090" ] }, "reaction_10554376": { "compartment": "compartment_70101", "id": "reaction_10554376", "reactome": "R-CEL-5654701", "name": "FGFR2-associated PI3K phosphorylates PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10543833", "catalyst" ] ], "additional_components": [ "E6N0V1", "WBGene00018819", "G5EDP9", "WBGene00000001", "P29355", "WBGene00004774", "G5EDJ4", "WBGene00004928", "Q94125", "WBGene00000090" ] }, "reaction_10554365": { "compartment": "compartment_70101", "id": "reaction_10554365", "reactome": "R-CEL-5654618", "name": "Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10512175", "species_29438" ], "products": [ "species_29420", "species_10511481" ], "modifiers": [ [ "species_10554362", "catalyst" ] ], "additional_components": [ "species_29420", "P22981", "WBGene00002335", "species_29438", "P22981", "WBGene00002335", "P29355", "WBGene00004774", "Q9N5D3", "WBGene00004947" ] }, "reaction_10562965": { "compartment": "compartment_7660", "id": "reaction_10562965", "reactome": "R-CEL-6803523", "name": "PTB and hnRNPA1 bind FGFR2 pre-mRNA to repress IIIb splicing and promote formation of FGFR2c mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10504458", "species_10504465", "species_10562961" ], "products": [ "species_10562963" ], "modifiers": [], "additional_components": [ "WBGene00004207", "WBGene00019881", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "P34541", "WBGene00019881", "Q18999", "WBGene00004207" ] }, "reaction_10554385": { "compartment": "compartment_70101", "id": "reaction_10554385", "reactome": "R-CEL-5654717", "name": "FGFR4-associated PI3K phosphorylates PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10543849", "catalyst" ] ], "additional_components": [ "E6N0V1", "WBGene00018819", "G5EDP9", "WBGene00000001", "P29355", "WBGene00004774", "G5EDJ4", "WBGene00004928", "Q94125", "WBGene00000090" ] }, "reaction_10554332": { "compartment": "compartment_70101", "id": "reaction_10554332", "reactome": "R-CEL-5654413", "name": "Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10512175", "species_29438" ], "products": [ "species_29420", "species_10511481" ], "modifiers": [ [ "species_10554329", "catalyst" ] ], "additional_components": [ "species_29420", "P22981", "WBGene00002335", "species_29438", "P22981", "WBGene00002335", "P29355", "WBGene00004774", "Q9N5D3", "WBGene00004947" ] }, "reaction_10554379": { "compartment": "compartment_70101", "id": "reaction_10554379", "reactome": "R-CEL-5654705", "name": "FGFR3-associated PI3K phosphorylates PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10543841", "catalyst" ] ], "additional_components": [ "Q94125", "WBGene00000090", "G5EDP9", "WBGene00000001", "P29355", "WBGene00004774", "G5EDJ4", "WBGene00004928", "E6N0V1", "WBGene00018819" ] }, "reaction_10554367": { "compartment": "compartment_70101", "id": "reaction_10554367", "reactome": "R-CEL-5654640", "name": "Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10543839", "species_10506890" ], "products": [ "species_10543841" ], "modifiers": [], "additional_components": [ "G5EDP9", "WBGene00000001", "P29355", "WBGene00004774", "G5EDJ4", "WBGene00004928", "E6N0V1", "WBGene00018819", "WBGene00000090", "Q94125", "WBGene00000090", "G5EDP9", "WBGene00000001", "P29355", "WBGene00004774", "G5EDJ4", "WBGene00004928", "E6N0V1", "WBGene00018819" ] }, "reaction_10554382": { "compartment": "compartment_70101", "id": "reaction_10554382", "reactome": "R-CEL-5654709", "name": "FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10543861", "catalyst" ] ], "additional_components": [ "E6N0V1", "WBGene00018819", "G5EDP9", "WBGene00000001", "P29355", "WBGene00004774", "G5EDJ4", "WBGene00004928", "Q94125", "WBGene00000090" ] }, "reaction_10546375": { "compartment": "compartment_70101", "id": "reaction_10546375", "reactome": "R-CEL-3134914", "name": "Beta-catenin migrates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546373" ], "products": [ "species_10546371" ], "modifiers": [], "additional_components": [ "WBGene00001979", "WBGene00001979" ] }, "reaction_10536514": { "compartment": "compartment_70101", "id": "reaction_10536514", "reactome": "R-CEL-1614567", "name": "Excess homocysteine yields homolanthionine and H2S", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_174369" ], "products": [ "species_1614532", "species_1614594" ], "modifiers": [ [ "species_10536511", "catalyst" ], [ "species_174369", "catalyst" ] ], "additional_components": [ "P55216", "WBGene00022856" ] }, "reaction_10571811": { "compartment": "compartment_5460", "id": "reaction_10571811", "reactome": "R-CEL-9034756", "name": "MPST transfers sulfur atom from 3MPYR to form CysS248-MPST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9012592", "species_10570931" ], "products": [ "species_113557", "species_10571809" ], "modifiers": [ [ "species_10570931", "catalyst" ] ], "additional_components": [ "WBGene00022006", "WBGene00022006", "WBGene00022006" ] }, "reaction_10571815": { "compartment": "compartment_5460", "id": "reaction_10571815", "reactome": "R-CEL-9035227", "name": "TXN2 binds CysS248-MPST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10547396", "species_10571809" ], "products": [ "species_10571813" ], "modifiers": [], "additional_components": [ "WBGene00007099", "WBGene00022006", "G5ECA0", "WBGene00022006", "Q17424", "WBGene00007099" ] }, "reaction_10536520": { "compartment": "compartment_70101", "id": "reaction_10536520", "reactome": "R-CEL-1614591", "name": "Excess cysteine yields lanthionine and H2S", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111707" ], "products": [ "species_1614582", "species_1614532" ], "modifiers": [ [ "species_10536511", "catalyst" ], [ "species_111707", "catalyst" ] ], "additional_components": [ "P55216", "WBGene00022856" ] }, "reaction_10571817": { "compartment": "compartment_5460", "id": "reaction_10571817", "reactome": "R-CEL-9035484", "name": "CysS248-MPST:TXN2 dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10571813" ], "products": [ "species_10547399", "species_10570931", "species_1655881" ], "modifiers": [], "additional_components": [ "G5ECA0", "WBGene00022006", "Q17424", "WBGene00007099", "WBGene00007099", "WBGene00022006" ] }, "reaction_10536553": { "compartment": "compartment_70101", "id": "reaction_10536553", "reactome": "R-CEL-1614645", "name": "CDO1:Fe2+ oxidises L-Cys to 3-Sulfinoalanine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111707", "species_29368" ], "products": [ "species_1614519" ], "modifiers": [ [ "species_10536550", "catalyst" ] ], "additional_components": [ "Q20893", "WBGene00018986", "species_113531" ] }, "reaction_10536501": { "compartment": "compartment_5460", "id": "reaction_10536501", "reactome": "R-CEL-1614544", "name": "Sulfite is oxidized to sulfate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113533", "species_1614538", "species_113521" ], "products": [ "species_1614617", "species_1614584" ], "modifiers": [ [ "species_10536498", "catalyst" ] ], "additional_components": [ "Q9XTQ8", "WBGene00010397", "species_947539" ] }, "reaction_10536503": { "compartment": "compartment_70616", "id": "reaction_10536503", "reactome": "R-CEL-1614546", "name": "Sulfate is exported to the cytosol in exchange for dicarboxylate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_198498", "species_1614584" ], "products": [ "species_113544", "species_174375" ], "modifiers": [ [ "species_10518419", "catalyst" ] ], "additional_components": [ "WBGene00019656" ] }, "reaction_10536538": { "compartment": "compartment_70616", "id": "reaction_10536538", "reactome": "R-CEL-1614605", "name": "Persulfide sulfur is dioxygenated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10536526", "species_113533", "species_113521" ], "products": [ "species_113529", "species_1614538", "species_10536528" ], "modifiers": [ [ "species_10536535", "catalyst" ] ], "additional_components": [ "WBGene00008538", "WBGene00008538", "O17636", "WBGene00007886", "species_216785" ] }, "reaction_10571219": { "compartment": "compartment_5460", "id": "reaction_10571219", "reactome": "R-CEL-9013471", "name": "MPST transfers sulfur from 3MPYR to HCN to form HSCN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9012592", "species_9013199" ], "products": [ "species_9013191", "species_113557" ], "modifiers": [ [ "species_10570931", "catalyst" ] ], "additional_components": [ "WBGene00022006" ] }, "reaction_10571186": { "compartment": "compartment_5460", "id": "reaction_10571186", "reactome": "R-CEL-9013198", "name": "TST transfers sulfur from S2O3(2-) to HCN to form HSCN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1614595", "species_9013199" ], "products": [ "species_9013207", "species_9013191" ], "modifiers": [ [ "species_10571183", "catalyst" ] ], "additional_components": [ "G5ECA0", "WBGene00022006", "O17730", "WBGene00008409", "G5EEV0", "WBGene00011307", "P91247", "WBGene00017387", "Q9XTX2", "WBGene00010380", "H9G340", "WBGene00010383" ] }, "reaction_10571221": { "compartment": "compartment_5460", "id": "reaction_10571221", "reactome": "R-CEL-9013533", "name": "MPST transfers sulfur from sulfanegen to HCN to form HSCN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9013543", "species_9013199" ], "products": [ "species_9013191", "species_113557" ], "modifiers": [ [ "species_10570931", "catalyst" ] ], "additional_components": [ "WBGene00022006" ] }, "reaction_10564244": { "compartment": "compartment_70101", "id": "reaction_10564244", "reactome": "R-CEL-6814153", "name": "ADO oxidises 2AET to HTAU", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_6814151" ], "products": [ "species_1655445", "species_70106" ], "modifiers": [ [ "species_10564241", "catalyst" ] ], "additional_components": [ "species_113531", "Q8IAA1", "WBGene00021750" ] }, "reaction_10570934": { "compartment": "compartment_5460", "id": "reaction_10570934", "reactome": "R-CEL-9012721", "name": "MPST transfers sulfur atom from 3MPYR to HSO3- to form S2O3(2-) and PYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9012724", "species_9012592" ], "products": [ "species_1614595", "species_113557" ], "modifiers": [ [ "species_10570931", "catalyst" ] ], "additional_components": [ "WBGene00022006" ] }, "reaction_10536540": { "compartment": "compartment_70101", "id": "reaction_10536540", "reactome": "R-CEL-1614614", "name": "Cysteine is degraded to serine and H2S", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_111707" ], "products": [ "species_1614532", "species_200736" ], "modifiers": [ [ "species_10536511", "catalyst" ] ], "additional_components": [ "P55216", "WBGene00022856" ] }, "reaction_10536543": { "compartment": "compartment_70101", "id": "reaction_10536543", "reactome": "R-CEL-1614631", "name": "Homocysteine is degraded to oxobutanoate and H2S", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_174369" ], "products": [ "species_1614532", "species_29382", "species_936714" ], "modifiers": [ [ "species_10536511", "catalyst" ] ], "additional_components": [ "P55216", "WBGene00022856" ] }, "reaction_10507392": { "compartment": "compartment_70101", "id": "reaction_10507392", "reactome": "R-CEL-75849", "name": "Transport of Citrate from Mitochondrial Matrix to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29654", "species_198498" ], "products": [ "species_76190", "species_113544" ], "modifiers": [ [ "species_10507389", "catalyst" ] ], "additional_components": [ "WBGene00010780" ] }, "reaction_10556609": { "compartment": "compartment_161320", "id": "reaction_10556609", "reactome": "R-CEL-5690517", "name": "PPT1 hydrolyses palmitoylated proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_5690533" ], "products": [ "species_6785219", "species_5690516" ], "modifiers": [ [ "species_10556606", "catalyst" ] ], "additional_components": [ "species_390435", "species_6785219", "WBGene00004092" ] }, "reaction_10527328": { "compartment": "compartment_70101", "id": "reaction_10527328", "reactome": "R-CEL-548843", "name": "ACSL3,4 ligate CoA to AA to form AA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_29768", "species_76194" ], "products": [ "species_111294", "species_29356", "species_548819", "species_76577" ], "modifiers": [ [ "species_10527325", "catalyst" ] ], "additional_components": [ "A0A4V0ING4", "WBGene00016716" ] }, "reaction_10527264": { "compartment": "compartment_70101", "id": "reaction_10527264", "reactome": "R-CEL-548800", "name": "ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_548819", "species_29508" ], "products": [ "species_113528", "species_548816", "species_76194" ], "modifiers": [ [ "species_10527261", "catalyst" ] ], "additional_components": [ "WBGene00001241" ] }, "reaction_10555303": { "compartment": "compartment_12045", "id": "reaction_10555303", "reactome": "R-CEL-5676637", "name": "PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5676631" ], "products": [ "species_29356", "species_5676634" ], "modifiers": [ [ "species_10555300", "catalyst" ] ], "additional_components": [ "O17040", "WBGene00020517" ] }, "reaction_10527321": { "compartment": "compartment_70101", "id": "reaction_10527321", "reactome": "R-CEL-548831", "name": "TECR,TECRL dehydrogenate TOD-CoA to ST-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_548809" ], "products": [ "species_428139", "species_29366" ], "modifiers": [ [ "species_10527316", "catalyst" ] ], "additional_components": [ "WBGene00000198" ] }, "reaction_10527308": { "compartment": "compartment_70101", "id": "reaction_10527308", "reactome": "R-CEL-548814", "name": "ELOVL3,6,7 elongate PALM-CoA and Mal-CoA to 3OOD-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29508", "species_200993" ], "products": [ "species_113528", "species_548812", "species_76194" ], "modifiers": [ [ "species_10527305", "catalyst" ] ], "additional_components": [ "Q9NAC6", "WBGene00001247", "Q20300", "WBGene00001243", "G5EEE5", "WBGene00001239", "Q9XVQ9", "WBGene00001240", "Q20303", "WBGene00001244", "P49191", "WBGene00001241", "Q20904", "WBGene00001245", "Q03574", "WBGene00001242" ] }, "reaction_10514751": { "compartment": "compartment_70101", "id": "reaction_10514751", "reactome": "R-CEL-201035", "name": "ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_3632881", "species_76194" ], "products": [ "species_111294", "species_29356", "species_200993", "species_76577" ], "modifiers": [ [ "species_10514748", "catalyst" ] ], "additional_components": [ "Q9XWD1", "WBGene00013575", "O16775", "WBGene00019920", "V6CLI5", "WBGene00022037", "O44560", "WBGene00020343", "Q21872", "WBGene00011173", "A0A4V0ING4", "WBGene00016716", "Q20121", "WBGene00018152" ] }, "reaction_10527311": { "compartment": "compartment_70101", "id": "reaction_10527311", "reactome": "R-CEL-548818", "name": "HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_548812" ], "products": [ "species_548836", "species_29366" ], "modifiers": [ [ "species_10513362", "catalyst" ] ], "additional_components": [ "WBGene00000969" ] }, "reaction_10507383": { "compartment": "compartment_70101", "id": "reaction_10507383", "reactome": "R-CEL-75848", "name": "ACLY tetramer transforms CIT to Ac-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76190", "species_113592", "species_76194" ], "products": [ "species_29372", "species_29370", "species_76183", "species_76213" ], "modifiers": [ [ "species_10507375", "catalyst" ], [ "species_10507381", "catalyst" ] ], "additional_components": [ "P53585", "WBGene00016995", "WBGene00022531" ] }, "reaction_10514618": { "compartment": "compartment_70101", "id": "reaction_10514618", "reactome": "R-CEL-200555", "name": "acetyl-CoA + bicarbonate + ATP => malonyl-CoA + H2O + ADP + orthophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111627", "species_113592", "species_76183" ], "products": [ "species_29372", "species_29370", "species_29508" ], "modifiers": [ [ "species_10507411", "catalyst" ], [ "species_76190", "catalyst" ] ], "additional_components": [ "Q9XUC3", "WBGene00012131", "H2L0M0", "WBGene00004076" ] }, "reaction_10556619": { "compartment": "compartment_12045", "id": "reaction_10556619", "reactome": "R-CEL-5690565", "name": "SCD desaturates ST-CoA to OLE-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428139", "species_70106", "species_4085415", "species_29368" ], "products": [ "species_4085425", "species_29356", "species_5690558" ], "modifiers": [ [ "species_10556616", "catalyst" ] ], "additional_components": [ "G5EGN2", "WBGene00001398" ] }, "reaction_10510254": { "compartment": "compartment_70101", "id": "reaction_10510254", "reactome": "R-CEL-163756", "name": "Formation of fatty acid synthase (FAS) dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10507450" ], "products": [ "species_10507452" ], "modifiers": [], "additional_components": [ "WBGene00009342", "P91871", "WBGene00009342" ] }, "reaction_10507455": { "compartment": "compartment_70101", "id": "reaction_10507455", "reactome": "R-CEL-75872", "name": "acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_76183", "species_29364", "species_29508" ], "products": [ "species_29356", "species_113528", "species_29366", "species_3632881", "species_76194" ], "modifiers": [ [ "species_10507452", "catalyst" ] ], "additional_components": [ "P91871", "WBGene00009342" ] }, "reaction_10564542": { "compartment": "compartment_12045", "id": "reaction_10564542", "reactome": "R-CEL-8847579", "name": "SCD5 desaturates ST-CoA to OLE-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428139", "species_70106", "species_4085415", "species_29368" ], "products": [ "species_4085425", "species_29356", "species_5690558" ], "modifiers": [ [ "species_10564539", "catalyst" ] ], "additional_components": [ "G5ED44", "WBGene00001397", "G5EGH6", "WBGene00001399", "G5EGN2", "WBGene00001398" ] }, "reaction_10571480": { "compartment": "compartment_70101", "id": "reaction_10571480", "reactome": "R-CEL-9018877", "name": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(R)-HEPE to 18(R)-RvE1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_9023708" ], "products": [ "species_9023712" ], "modifiers": [ [ "species_10517863", "catalyst" ] ], "additional_components": [ "species_216785", "G5EFT4", "WBGene00016589" ] }, "reaction_10571482": { "compartment": "compartment_70101", "id": "reaction_10571482", "reactome": "R-CEL-9018895", "name": "GPX4-2 reduces 18(R)-HpEPE to 18(R)-HEPE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9023653", "species_29450" ], "products": [ "species_29356", "species_9023651", "species_111745" ], "modifiers": [ [ "species_10571475", "catalyst" ] ], "additional_components": [ "WBGene00019846" ] }, "reaction_10569921": { "compartment": "compartment_17947", "id": "reaction_10569921", "reactome": "R-CEL-8953946", "name": "PEX2:PEX10:PEX12 monoubiquitinates PEX5S,L at cysteine-11", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10569909" ], "products": [ "species_10569918", "species_10532186" ], "modifiers": [ [ "species_10569909", "catalyst" ] ], "additional_components": [ "P35129", "WBGene00002344", "P91853", "WBGene00006732", "Q17720", "WBGene00006717", "Q20617", "WBGene00006719", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "Q19951", "WBGene00004198", "Q93930", "WBGene00004199", "Q18355", "WBGene00016318", "Q19189", "WBGene00004197", "Q18426", "WBGene00004194", "Q19951", "WBGene00004198", "Q93930", "WBGene00004199", "Q18355", "WBGene00016318", "Q19189", "WBGene00004197", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "Q18426", "WBGene00004194", "P35129", "WBGene00002344", "P91853", "WBGene00006732", "Q17720", "WBGene00006717", "Q20617", "WBGene00006719", "P35129", "WBGene00002344", "P91853", "WBGene00006732", "Q17720", "WBGene00006717", "Q20617", "WBGene00006719", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "Q19951", "WBGene00004198", "Q93930", "WBGene00004199", "Q18355", "WBGene00016318", "Q19189", "WBGene00004197", "Q18426", "WBGene00004194" ] }, "reaction_10569911": { "compartment": "compartment_17947", "id": "reaction_10569911", "reactome": "R-CEL-8953917", "name": "PEX2:PEX10:PEX12 binds PEX5S,L (in PEX5S:PEX13:PEX14) and Ub:UBE2D1,2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10569900", "species_10569907" ], "products": [ "species_10569909" ], "modifiers": [], "additional_components": [ "Q19951", "WBGene00004198", "Q93930", "WBGene00004199", "Q18355", "WBGene00016318", "Q19189", "WBGene00004197", "Q18426", "WBGene00004194", "P35129", "WBGene00002344", "P91853", "WBGene00006732", "Q17720", "WBGene00006717", "Q20617", "WBGene00006719", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "P35129", "WBGene00002344", "P91853", "WBGene00006732", "Q17720", "WBGene00006717", "Q20617", "WBGene00006719", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "Q19951", "WBGene00004198", "Q93930", "WBGene00004199", "Q18355", "WBGene00016318", "Q19189", "WBGene00004197", "Q18426", "WBGene00004194" ] }, "reaction_10568412": { "compartment": "compartment_70101", "id": "reaction_10568412", "reactome": "R-CEL-8938815", "name": "RNF152 polyubiquitinates RRAGA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10568399", "species_10568401" ], "products": [ "species_10568392", "species_10568409", "species_10515250" ], "modifiers": [ [ "species_10568401", "catalyst" ] ], "additional_components": [ "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "Q95XX0", "WBGene00006708", "Q19214", "WBGene00008588", "species_29420", "Q22743", "WBGene00006414", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "Q95XX0", "WBGene00006708", "WBGene00008588", "Q22743", "WBGene00006414", "species_29420", "WBGene00006708", "Q19214", "WBGene00008588", "species_29420", "Q22743", "WBGene00006414", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "Q95XX0", "WBGene00006708" ] }, "reaction_10568414": { "compartment": "compartment_70101", "id": "reaction_10568414", "reactome": "R-CEL-8938829", "name": "RNF152 binds RRAGA:GDP and Ubiquitin:UBE2D3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10568399", "species_10568394", "species_10568392" ], "products": [ "species_10568401" ], "modifiers": [], "additional_components": [ "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "Q95XX0", "WBGene00006708", "species_29420", "Q22743", "WBGene00006414", "WBGene00008588", "Q19214", "WBGene00008588", "species_29420", "Q22743", "WBGene00006414", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "Q95XX0", "WBGene00006708" ] }, "reaction_10551718": { "compartment": "compartment_12045", "id": "reaction_10551718", "reactome": "R-CEL-5362412", "name": "SYVN1 ubiquitinates Hh C-terminal fragments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10551711", "species_10502375" ], "products": [ "species_10551715" ], "modifiers": [ [ "species_10551711", "catalyst" ] ], "additional_components": [ "Q09396", "WBGene00018611", "Q9NF22", "WBGene00013667", "G5EFG0", "WBGene00004759", "Q21997", "WBGene00020109", "P54812", "WBGene00008053", "Q20798", "WBGene00004768", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "Q09396", "WBGene00018611", "Q9NF22", "WBGene00013667", "G5EFG0", "WBGene00004759", "Q21997", "WBGene00020109", "P54812", "WBGene00008053", "Q20798", "WBGene00004768", "Q09396", "WBGene00018611", "Q9NF22", "WBGene00013667", "G5EFG0", "WBGene00004759", "Q21997", "WBGene00020109", "P54812", "WBGene00008053", "Q20798", "WBGene00004768" ] }, "reaction_10552665": { "compartment": "compartment_876", "id": "reaction_10552665", "reactome": "R-CEL-5610727", "name": "GPR161 promotes cAMP production in a G alpha(s)-dependent manner", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592" ], "products": [ "species_111294", "species_30389" ], "modifiers": [ [ "species_10552658", "catalyst" ], [ "species_10552663", "catalyst" ] ], "additional_components": [ "species_114632", "Q09306", "WBGene00006655", "Q20255", "WBGene00022696", "Q18859", "WBGene00016935", "G5EFW7", "WBGene00000906", "G5ECZ4", "WBGene00001118", "P90757", "WBGene00000490" ] }, "reaction_10552670": { "compartment": "compartment_70101", "id": "reaction_10552670", "reactome": "R-CEL-5610735", "name": "NUMB binds ITCH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10524550", "species_10530869" ], "products": [ "species_10552668" ], "modifiers": [], "additional_components": [ "WBGene00003830", "WBGene00007009", "Q9N2Z7", "WBGene00007009", "Q9XTY6", "WBGene00003830" ] }, "reaction_10552682": { "compartment": "compartment_5263232", "id": "reaction_10552682", "reactome": "R-CEL-5610749", "name": "cAMP dissociates PKA, promoting GLI processing", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10552678", "species_30389" ], "products": [ "species_10552680", "species_10552672" ], "modifiers": [], "additional_components": [ "P21137", "WBGene00002189", "P30625", "WBGene00002190", "P30625", "WBGene00002190", "species_30389", "WBGene00002189" ] }, "reaction_10552654": { "compartment": "compartment_18730", "id": "reaction_10552654", "reactome": "R-CEL-5610726", "name": "The IFT-A complex recruits TULP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10552650", "species_10552619" ], "products": [ "species_10552652" ], "modifiers": [], "additional_components": [ "Q20255", "WBGene00022696", "Q18859", "WBGene00016935", "G5EFW7", "WBGene00000906", "G5ECZ4", "WBGene00001118", "P90757", "WBGene00000490", "WBGene00006655", "Q09306", "WBGene00006655", "Q20255", "WBGene00022696", "Q18859", "WBGene00016935", "G5EFW7", "WBGene00000906", "G5ECZ4", "WBGene00001118", "P90757", "WBGene00000490" ] }, "reaction_10554098": { "compartment": "compartment_7660", "id": "reaction_10554098", "reactome": "R-CEL-5635854", "name": "GLI2,3 are degraded by the proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10554096" ], "products": [ "species_10554094", "species_10502318" ], "modifiers": [ [ "species_10512606", "catalyst" ] ], "additional_components": [ "Q23457", "WBGene00004320", "P34568", "WBGene00011815", "Q9NF14", "WBGene00013689", "H2KYJ3", "WBGene00015567", "P41886", "WBGene00018137", "Q94420", "WBGene00003209", "P34371", "WBGene00016803", "Q17391", "WBGene00000838", "Q23457", "WBGene00004320", "P34568", "WBGene00011815", "Q9NF14", "WBGene00013689", "H2KYJ3", "WBGene00015567", "P41886", "WBGene00018137", "Q94420", "WBGene00003209", "P34371", "WBGene00016803", "Q17391", "WBGene00000838", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "Q23237", "WBGene00003949", "P90868", "WBGene00003953", "Q9XUV0", "WBGene00003951", "Q966I8", "WBGene00003947", "O62102", "WBGene00003948", "O16368", "WBGene00004502", "Q18787", "WBGene00004501", "O76371", "WBGene00004505", "P46502", "WBGene00004503", "Q9XTT9", "WBGene00004506", "O17071", "WBGene00004504", "Q18115", "WBGene00004459", "Q20938", "WBGene00004462", "Q19324", "WBGene00004461", "Q22253", "WBGene00004465", "Q9GZH5", "WBGene00004458", "Q04908", "WBGene00004460", "O61742", "WBGene00004466", "O76577", "WBGene00004467", "Q20058", "WBGene00009445", "O44156", "WBGene00003927", "Q20585", "WBGene00004463", "Q27488", "WBGene00003923", "O61792", "WBGene00004464", "Q09583", "WBGene00003928", "Q23449", "WBGene00004468", "Q9N599", "WBGene00003924", "Q10920", "WBGene00016623", "Q95008", "WBGene00003926", "Q95PZ7", "WBGene00013435", "O17586", "WBGene00003922", "Q95005", "WBGene00003925", "P34286", "WBGene00003952", "P91477", "WBGene00003950" ] }, "reaction_10554020": { "compartment": "compartment_261122", "id": "reaction_10554020", "reactome": "R-CEL-5632677", "name": "PTCH is internalized", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10554012" ], "products": [ "species_10554018" ], "modifiers": [], "additional_components": [ "H2L0G5", "WBGene00004210", "Q09614", "WBGene00004208", "Q09614", "WBGene00004208", "H2L0G5", "WBGene00004210" ] }, "reaction_10554105": { "compartment": "compartment_7660", "id": "reaction_10554105", "reactome": "R-CEL-5635856", "name": "SPOP:CUL3:RBX1 ubiquitinates GLI2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502318", "species_10554102" ], "products": [ "species_10554096" ], "modifiers": [ [ "species_10554102", "catalyst" ] ], "additional_components": [ "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "Q23457", "WBGene00004320", "P34568", "WBGene00011815", "Q9NF14", "WBGene00013689", "H2KYJ3", "WBGene00015567", "P41886", "WBGene00018137", "Q94420", "WBGene00003209", "P34371", "WBGene00016803", "Q17391", "WBGene00000838", "Q23457", "WBGene00004320", "P34568", "WBGene00011815", "Q9NF14", "WBGene00013689", "H2KYJ3", "WBGene00015567", "P41886", "WBGene00018137", "Q94420", "WBGene00003209", "P34371", "WBGene00016803", "Q17391", "WBGene00000838", "Q23457", "WBGene00004320", "P34568", "WBGene00011815", "Q9NF14", "WBGene00013689", "H2KYJ3", "WBGene00015567", "P41886", "WBGene00018137", "Q94420", "WBGene00003209", "P34371", "WBGene00016803", "Q17391", "WBGene00000838" ] }, "reaction_10557600": { "compartment": "compartment_70101", "id": "reaction_10557600", "reactome": "R-CEL-5696230", "name": "GSTO1 dimer reduces methylarsonate to methylarsonite", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29450", "species_5696214" ], "products": [ "species_29356", "species_5696224", "species_111745" ], "modifiers": [ [ "species_10511838", "catalyst" ] ], "additional_components": [ "P34345", "WBGene00016204" ] }, "reaction_10511831": { "compartment": "compartment_70101", "id": "reaction_10511831", "reactome": "R-CEL-175987", "name": "NNMT transfers CH3 from AdoMet to PY", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_175973", "species_71284" ], "products": [ "species_175979", "species_71285" ], "modifiers": [ [ "species_10511828", "catalyst" ] ], "additional_components": [ "WBGene00015124" ] }, "reaction_10511767": { "compartment": "compartment_70101", "id": "reaction_10511767", "reactome": "R-CEL-174374", "name": "MTR transfers CH3 from MeCbl to HCYS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_174369", "species_10511760" ], "products": [ "species_174390", "species_10511764" ], "modifiers": [ [ "species_10511760", "catalyst" ] ], "additional_components": [ "species_73524", "Q17574", "WBGene00006510", "species_113596", "species_216785", "CHEBI:28115", "Q09582", "WBGene00010988", "species_216785", "species_3159260", "Q09582", "WBGene00010988", "species_73524", "Q17574", "WBGene00006510", "species_113596", "species_73524", "Q17574", "WBGene00006510", "species_113596", "species_216785", "CHEBI:28115", "Q09582", "WBGene00010988" ] }, "reaction_10511802": { "compartment": "compartment_70101", "id": "reaction_10511802", "reactome": "R-CEL-174401", "name": "AHCY:NAD+ tetramer hydrolyses AdoHcy", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_71285" ], "products": [ "species_83909", "species_174369" ], "modifiers": [ [ "species_10511799", "catalyst" ] ], "additional_components": [ "species_29360", "P27604", "WBGene00019322" ] }, "reaction_10562143": { "compartment": "compartment_70101", "id": "reaction_10562143", "reactome": "R-CEL-6800149", "name": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to MMAIII", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6806829", "species_71284" ], "products": [ "species_6800127", "species_71285" ], "modifiers": [ [ "species_10562137", "catalyst" ] ], "additional_components": [ "O16582", "WBGene00016341", "O45241", "WBGene00007312" ] }, "reaction_10509986": { "compartment": "compartment_70101", "id": "reaction_10509986", "reactome": "R-CEL-159358", "name": "SULT1A3,4 dimers sulfate DA to DAOS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158471", "species_159362" ], "products": [ "species_159352", "species_158466" ], "modifiers": [ [ "species_10509940", "catalyst" ] ], "additional_components": [ "Q9U2Z2", "WBGene00013748" ] }, "reaction_10511970": { "compartment": "compartment_70101", "id": "reaction_10511970", "reactome": "R-CEL-176517", "name": "SULTs transfer (SO4)2- group to PREG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193103", "species_158471" ], "products": [ "species_176665", "species_158466" ], "modifiers": [ [ "species_10511967", "catalyst" ] ], "additional_components": [ "Q9U2Z2", "WBGene00013748" ] }, "reaction_10512002": { "compartment": "compartment_70101", "id": "reaction_10512002", "reactome": "R-CEL-176631", "name": "dehydroepiandrosterone (DHEA) + PAPS => DHEA sulfate + PAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158471", "species_176626" ], "products": [ "species_176496", "species_158466" ], "modifiers": [ [ "species_10511999", "catalyst" ] ], "additional_components": [ "Q9U2Z2", "WBGene00013748" ] }, "reaction_10511777": { "compartment": "compartment_70101", "id": "reaction_10511777", "reactome": "R-CEL-174389", "name": "PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_174370" ], "products": [ "species_29370", "species_158471" ], "modifiers": [ [ "species_10511772", "catalyst" ] ], "additional_components": [ "WBGene00004091" ] }, "reaction_10522868": { "compartment": "compartment_876", "id": "reaction_10522868", "reactome": "R-CEL-427555", "name": "SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_427648" ], "products": [ "species_70106", "species_174375" ], "modifiers": [ [ "species_10522865", "catalyst" ] ], "additional_components": [ "O17951", "WBGene00010789", "G5EEA7", "WBGene00010788", "O45016", "WBGene00020914", "G5EED0", "WBGene00016945", "Q94225", "WBGene00018283", "G5EFB2", "WBGene00013963", "G5EC30", "WBGene00012259" ] }, "reaction_10511780": { "compartment": "compartment_70101", "id": "reaction_10511780", "reactome": "R-CEL-174392", "name": "PAPSS1,2 transfer SO4(2-) group to ATP to form APS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_174375" ], "products": [ "species_111294", "species_174370" ], "modifiers": [ [ "species_10511772", "catalyst" ] ], "additional_components": [ "WBGene00004091" ] }, "reaction_10527852": { "compartment": "compartment_20699", "id": "reaction_10527852", "reactome": "R-CEL-741449", "name": "SLC35B2,3 transport cytosolic PAPS to Golgi lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158471" ], "products": [ "species_741440" ], "modifiers": [ [ "species_10527849", "catalyst" ] ], "additional_components": [ "Q8MXJ9", "WBGene00004206", "Q20787", "WBGene00018827" ] }, "reaction_10511973": { "compartment": "compartment_70101", "id": "reaction_10511973", "reactome": "R-CEL-176521", "name": "beta-estradiol + PAPS => beta-estradiol 3-sulfate + PAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_176619", "species_158471" ], "products": [ "species_176492", "species_158466" ], "modifiers": [ [ "species_10511945", "catalyst" ] ], "additional_components": [ "Q9U2Z2", "WBGene00013748" ] }, "reaction_10569867": { "compartment": "compartment_17963", "id": "reaction_10569867", "reactome": "R-CEL-8953499", "name": "IMPAD1 hydrolyses PAP to AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_742343", "species_2022884" ], "products": [ "species_8851226", "species_8953493" ], "modifiers": [ [ "species_10569864", "catalyst" ], [ "species_8953505", "inhibitor" ] ], "additional_components": [ "species_114632", "Q5ZEQ3", "WBGene00012390" ] }, "reaction_10512011": { "compartment": "compartment_70101", "id": "reaction_10512011", "reactome": "R-CEL-176646", "name": "p-nitrophenol + PAPS => p-nitrophenol sulfate + PAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5695950", "species_158471" ], "products": [ "species_176600", "species_158466" ], "modifiers": [ [ "species_10512008", "catalyst" ] ], "additional_components": [ "Q9U2Z2", "WBGene00013748" ] }, "reaction_10511982": { "compartment": "compartment_70101", "id": "reaction_10511982", "reactome": "R-CEL-176585", "name": "3,5,3'-triiodothyronine + PAPS => 3,5,3'-triiodothyronine 4-sulfate + PAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_176667", "species_158471" ], "products": [ "species_176564", "species_158466" ], "modifiers": [ [ "species_10511979", "catalyst" ] ], "additional_components": [ "Q9U2Z2", "WBGene00013748" ] }, "reaction_10512016": { "compartment": "compartment_70101", "id": "reaction_10512016", "reactome": "R-CEL-176664", "name": "estrone + PAPS => estrone 3-sulfate + PAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_176575", "species_158471" ], "products": [ "species_176501", "species_158466" ], "modifiers": [ [ "species_10512013", "catalyst" ] ], "additional_components": [ "Q9U2Z2", "WBGene00013748" ] }, "reaction_10511985": { "compartment": "compartment_70101", "id": "reaction_10511985", "reactome": "R-CEL-176588", "name": "lithocholate + PAPS => lithocholate sulfate + PAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_176655", "species_158471" ], "products": [ "species_176555", "species_158466" ], "modifiers": [ [ "species_10511949", "catalyst" ] ], "additional_components": [ "Q9U2Z2", "WBGene00013748" ] }, "reaction_10511987": { "compartment": "compartment_70101", "id": "reaction_10511987", "reactome": "R-CEL-176604", "name": "taurolithocholate + PAPS => taurolithocholate sulfate + PAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_176565", "species_158471" ], "products": [ "species_176483", "species_158466" ], "modifiers": [ [ "species_10511949", "catalyst" ] ], "additional_components": [ "Q9U2Z2", "WBGene00013748" ] }, "reaction_10512021": { "compartment": "compartment_70101", "id": "reaction_10512021", "reactome": "R-CEL-176669", "name": "N-hydroxy-2-acetylaminofluorene + PAPS => 2-acetylaminofluorene-N-sulfate + PAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158471", "species_176566" ], "products": [ "species_176500", "species_158466" ], "modifiers": [ [ "species_10512018", "catalyst" ] ], "additional_components": [ "Q9U2Z2", "WBGene00013748" ] }, "reaction_10511958": { "compartment": "compartment_70101", "id": "reaction_10511958", "reactome": "R-CEL-176474", "name": "3,3'-diiodothyronine + PAPS => 3,3'-diiodothyronine 4-sulfate + PAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158471", "species_176486" ], "products": [ "species_176519", "species_158466" ], "modifiers": [ [ "species_10511955", "catalyst" ] ], "additional_components": [ "Q9U2Z2", "WBGene00013748" ] }, "reaction_10509943": { "compartment": "compartment_70101", "id": "reaction_10509943", "reactome": "R-CEL-158468", "name": "SULT1A1 dimer sulfonates PARA to PARA-SO4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158469", "species_158471" ], "products": [ "species_158472", "species_158466" ], "modifiers": [ [ "species_10509940", "catalyst" ] ], "additional_components": [ "Q9U2Z2", "WBGene00013748" ] }, "reaction_10511995": { "compartment": "compartment_70101", "id": "reaction_10511995", "reactome": "R-CEL-176606", "name": "Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_158466" ], "products": [ "species_29372", "species_76577" ], "modifiers": [ [ "species_10511992", "catalyst" ] ], "additional_components": [ "WBGene00044063" ] }, "reaction_10509949": { "compartment": "compartment_70101", "id": "reaction_10509949", "reactome": "R-CEL-158849", "name": "Phenol can form a sulfate conjugate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158858", "species_158471" ], "products": [ "species_158466", "species_158850" ], "modifiers": [ [ "species_10509940", "catalyst" ] ], "additional_components": [ "Q9U2Z2", "WBGene00013748" ] }, "reaction_10511997": { "compartment": "compartment_70101", "id": "reaction_10511997", "reactome": "R-CEL-176609", "name": "cholesterol + PAPS => cholesterol sulfate + PAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_176478", "species_158471" ], "products": [ "species_176618", "species_158466" ], "modifiers": [ [ "species_10511962", "catalyst" ] ], "additional_components": [ "Q9U2Z2", "WBGene00013748" ] }, "reaction_10511965": { "compartment": "compartment_70101", "id": "reaction_10511965", "reactome": "R-CEL-176494", "name": "SULTs transfer (SO4)2- group to 27HCHOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_176617", "species_158471" ], "products": [ "species_176502", "species_158466" ], "modifiers": [ [ "species_10511962", "catalyst" ] ], "additional_components": [ "Q9U2Z2", "WBGene00013748" ] }, "reaction_10509951": { "compartment": "compartment_70101", "id": "reaction_10509951", "reactome": "R-CEL-158860", "name": "SULT1A1 dimer sulfonates NHABP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158847", "species_158471" ], "products": [ "species_158859", "species_158466" ], "modifiers": [ [ "species_10509940", "catalyst" ] ], "additional_components": [ "Q9U2Z2", "WBGene00013748" ] }, "reaction_10510057": { "compartment": "compartment_5460", "id": "reaction_10510057", "reactome": "R-CEL-159566", "name": "benzoyl-CoA + glycine => benzoyl glycine (hippuric acid) + Coenzyme A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_159549", "species_159447" ], "products": [ "species_29374", "species_159564" ], "modifiers": [ [ "species_10510054", "catalyst" ] ], "additional_components": [ "Q95ZT6", "WBGene00018400", "Q22371", "WBGene00018400" ] }, "reaction_10510059": { "compartment": "compartment_5460", "id": "reaction_10510059", "reactome": "R-CEL-159574", "name": "salicylate-CoA + glycine => salicyluric acid + Coenzyme A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_159549", "species_159557" ], "products": [ "species_29374", "species_159572" ], "modifiers": [ [ "species_10510054", "catalyst" ] ], "additional_components": [ "Q95ZT6", "WBGene00018400", "Q22371", "WBGene00018400" ] }, "reaction_10511744": { "compartment": "compartment_12045", "id": "reaction_10511744", "reactome": "R-CEL-174368", "name": "SLC35D1 hexamer transports UDP-GlcA, UDP-GlcNAc from cytosol to endoplasmic reticulum lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158601", "species_162756" ], "products": [ "species_3499326", "species_174384" ], "modifiers": [ [ "species_10511741", "catalyst" ] ], "additional_components": [ "Q18779", "WBGene00005025" ] }, "reaction_10502868": { "compartment": "compartment_70101", "id": "reaction_10502868", "reactome": "R-CEL-70286", "name": "UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29548", "species_29494" ], "products": [ "species_111294", "species_29410" ], "modifiers": [ [ "species_10502865", "catalyst" ] ], "additional_components": [ "Q9XUS5", "WBGene00010665" ] }, "reaction_10511557": { "compartment": "compartment_70101", "id": "reaction_10511557", "reactome": "R-CEL-173597", "name": "UDP-glucose is oxidised to UDP-glucuronate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_29410", "species_29360" ], "products": [ "species_70106", "species_158601", "species_73473" ], "modifiers": [ [ "species_10511554", "catalyst" ] ], "additional_components": [ "Q19905", "WBGene00005022" ] }, "reaction_10557073": { "compartment": "compartment_17957", "id": "reaction_10557073", "reactome": "R-CEL-5693724", "name": "ESD dimer hydrolyses S-FGSH to GSH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113519", "species_5693723" ], "products": [ "species_158543", "species_194712" ], "modifiers": [ [ "species_10557070", "catalyst" ] ], "additional_components": [ "G5EF86", "WBGene00013018" ] }, "reaction_10547222": { "compartment": "compartment_5460", "id": "reaction_10547222", "reactome": "R-CEL-3301943", "name": "GSTK1 dimer transfers GS from GSH to CDNB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1655887", "species_3301954" ], "products": [ "species_3301973", "species_3301969" ], "modifiers": [ [ "species_10547219", "catalyst" ] ], "additional_components": [ "Q18973", "WBGene00017054" ] }, "reaction_10532353": { "compartment": "compartment_70101", "id": "reaction_10532353", "reactome": "R-CEL-1247935", "name": "OPLAH hydrolyses OPRO to L-Glu", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_1247942" ], "products": [ "species_29372", "species_29404", "species_29370" ], "modifiers": [ [ "species_10532350", "catalyst" ] ], "additional_components": [ "A0A9S2", "WBGene00021430" ] }, "reaction_10511734": { "compartment": "compartment_70101", "id": "reaction_10511734", "reactome": "R-CEL-174367", "name": "GCL ligates L-Glu to L-Cys", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29404", "species_111707", "species_113592" ], "products": [ "species_29372", "species_174393", "species_29370" ], "modifiers": [ [ "species_10511731", "catalyst" ] ], "additional_components": [ "A9CZN9", "WBGene00017084", "Q20117", "WBGene00001527" ] }, "reaction_10532343": { "compartment": "compartment_70101", "id": "reaction_10532343", "reactome": "R-CEL-1247922", "name": "GGCT transforms gGluCys to OPRO", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_174393" ], "products": [ "species_111707", "species_1247942" ], "modifiers": [ [ "species_10532340", "catalyst" ] ], "additional_components": [ "Q18596", "WBGene00016629" ] }, "reaction_10568716": { "compartment": "compartment_876", "id": "reaction_10568716", "reactome": "R-CEL-8943279", "name": "GGT dimers hydrolyse GSH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_1247892" ], "products": [ "species_210382", "species_1247934" ], "modifiers": [ [ "species_10552351", "catalyst" ] ], "additional_components": [ "H2L0B7", "WBGene00020590", "O18256", "WBGene00020590", "Q9N5V4", "WBGene00020590", "A0A486WVP7", "WBGene00020590", "B5BM47", "WBGene00020590" ] }, "reaction_10532333": { "compartment": "compartment_70101", "id": "reaction_10532333", "reactome": "R-CEL-1247910", "name": "CNDP2:2Mn2+ dimer hydrolyses CysGly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1247904" ], "products": [ "species_111707", "species_29424" ], "modifiers": [ [ "species_10532330", "catalyst" ] ], "additional_components": [ "O18000", "WBGene00003982", "species_266099" ] }, "reaction_10511790": { "compartment": "compartment_70101", "id": "reaction_10511790", "reactome": "R-CEL-174394", "name": "GSS:Mg2+ dimer synthesizes GSH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_174393", "species_113592", "species_29424" ], "products": [ "species_29372", "species_29370", "species_29450" ], "modifiers": [ [ "species_10511787", "catalyst" ], [ "species_29450", "inhibitor" ] ], "additional_components": [ "species_114632", "Q21549", "WBGene00010941" ] }, "reaction_10511885": { "compartment": "compartment_70101", "id": "reaction_10511885", "reactome": "R-CEL-176054", "name": "GST dimers conjugate GSH with cytosolic substrates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29450", "species_176070" ], "products": [ "species_176049" ], "modifiers": [ [ "species_10511882", "catalyst" ] ], "additional_components": [ "CHEBI:29132", "species_3301954", "CHEBI:30614", "species_3301969", "CHEBI:32639", "CHEBI:34479", "Q18938", "WBGene00001790", "P34277", "WBGene00015337", "D7SFI3", "WBGene00043097", "P34345", "WBGene00016204", "O17234", "WBGene00019636", "O45352", "WBGene00001792", "Q09607", "WBGene00001784", "P10299", "WBGene00001749" ] }, "reaction_10556844": { "compartment": "compartment_70101", "id": "reaction_10556844", "reactome": "R-CEL-5692232", "name": "AKR1A1 oxidises BaPtDHD to BaP-7,8-dione", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29366", "species_5692212" ], "products": [ "species_5692216", "species_29364" ], "modifiers": [ [ "species_10554514", "catalyst" ] ], "additional_components": [ "WBGene00012722" ] }, "reaction_10510318": { "compartment": "compartment_20699", "id": "reaction_10510318", "reactome": "R-CEL-163843", "name": "Furin cleaves pro-GAS6 to GAS6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10510296" ], "products": [ "species_10510310", "species_10510304" ], "modifiers": [ [ "species_10510315", "catalyst" ] ], "additional_components": [ "G5EFX3", "WBGene00013416", "Q9XWD6", "WBGene00000415", "G5EFX3", "WBGene00013416", "Q9XWD6", "WBGene00000415", "G5EFX3", "WBGene00013416", "Q9XWD6", "WBGene00000415", "WBGene00002232" ] }, "reaction_10510298": { "compartment": "compartment_13959", "id": "reaction_10510298", "reactome": "R-CEL-163809", "name": "Gamma-carboxy pro-GAS6 transport from the endoplasmic reticulum to the Golgi apparatus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10510290" ], "products": [ "species_10510296" ], "modifiers": [], "additional_components": [ "G5EFX3", "WBGene00013416", "Q9XWD6", "WBGene00000415", "G5EFX3", "WBGene00013416", "Q9XWD6", "WBGene00000415" ] }, "reaction_10558353": { "compartment": "compartment_70101", "id": "reaction_10558353", "reactome": "R-CEL-6788867", "name": "FN3K phosphorylates ketosamines", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_6788868" ], "products": [ "species_29370", "species_6788848" ], "modifiers": [ [ "species_10558348", "catalyst" ] ], "additional_components": [ "CHEBI:87176", "CHEBI:24103", "CHEBI:87177", "CHEBI:87180", "CHEBI:87178", "CHEBI:87179", "WBGene00013802" ] }, "reaction_10516057": { "compartment": "compartment_70101", "id": "reaction_10516057", "reactome": "R-CEL-204662", "name": "DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29368", "species_10516005", "species_73473" ], "products": [ "species_10516047", "species_29356", "species_29360" ], "modifiers": [ [ "species_10516054", "catalyst" ] ], "additional_components": [ "Q20751", "WBGene00002065", "P34563", "WBGene00002064", "P34563", "WBGene00002064", "Q20751", "WBGene00002065", "Q17949", "WBGene00007555", "species_113531" ] }, "reaction_10516029": { "compartment": "compartment_70101", "id": "reaction_10516029", "reactome": "R-CEL-204617", "name": "DHPS tetramer synthesizes EIF5A and spermidine from Dhp-K50-EIF5A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_204628", "species_10516005", "species_73473" ], "products": [ "species_204635", "species_10516019", "species_29360" ], "modifiers": [ [ "species_10516026", "catalyst" ] ], "additional_components": [ "Q20751", "WBGene00002065", "P34563", "WBGene00002064", "P34563", "WBGene00002064", "Q20751", "WBGene00002065", "Q9XXJ0", "WBGene00012460" ] }, "reaction_10551593": { "compartment": "compartment_70101", "id": "reaction_10551593", "reactome": "R-CEL-5358484", "name": "DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10551582", "species_71284" ], "products": [ "species_71285", "species_10551585" ], "modifiers": [ [ "species_10551590", "catalyst" ] ], "additional_components": [ "WBGene00001167", "WBGene00001167", "WBGene00007194" ] }, "reaction_10551579": { "compartment": "compartment_70101", "id": "reaction_10551579", "reactome": "R-CEL-5358475", "name": "DPH6 ligates ammonium to diphthine-EEF2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10551571", "species_31633" ], "products": [ "species_111294", "species_10509919", "species_76577" ], "modifiers": [ [ "species_10551576", "catalyst" ] ], "additional_components": [ "WBGene00001167", "WBGene00001167", "WBGene00017087" ] }, "reaction_10551615": { "compartment": "compartment_70101", "id": "reaction_10551615", "reactome": "R-CEL-5358494", "name": "DPH2 transfers a 3-amino-3-carboxypropyl group from AdoMet to residue 715 of nascent EEF2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10551595", "species_71284" ], "products": [ "species_10551582", "species_353106" ], "modifiers": [ [ "species_10551612", "catalyst" ] ], "additional_components": [ "WBGene00001167", "WBGene00001167", "P49958", "WBGene00007576", "Q09454", "WBGene00007488", "Q21102", "WBGene00010484" ] }, "reaction_10558335": { "compartment": "compartment_12045", "id": "reaction_10558335", "reactome": "R-CEL-6788650", "name": "ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6788753", "species_71284" ], "products": [ "species_71285", "species_6788758" ], "modifiers": [ [ "species_10558332", "catalyst" ] ], "additional_components": [ "species_216785", "P91402", "WBGene00019710" ] }, "reaction_10558351": { "compartment": "compartment_70101", "id": "reaction_10558351", "reactome": "R-CEL-6788855", "name": "FN3KRP phosphorylates PsiAm, RibAm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_6788865" ], "products": [ "species_6788858", "species_29370" ], "modifiers": [ [ "species_10558348", "catalyst" ] ], "additional_components": [ "CHEBI:87176", "CHEBI:87177", "CHEBI:87180", "CHEBI:87179", "WBGene00013802" ] }, "reaction_10570837": { "compartment": "compartment_876", "id": "reaction_10570837", "reactome": "R-CEL-9010872", "name": "SLIT2 binds Dystroglycan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10519315", "species_10570833" ], "products": [ "species_10570835" ], "modifiers": [], "additional_components": [ "WBGene00004854", "O61756", "WBGene00018943", "Q22629", "WBGene00000961", "O61756", "WBGene00018943", "Q22629", "WBGene00000961", "G5EFX6", "WBGene00004854" ] }, "reaction_10564693": { "compartment": "compartment_20699", "id": "reaction_10564693", "reactome": "R-CEL-8848484", "name": "PLA2s hydrolyze phospholipids at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_429785", "species_29356" ], "products": [ "species_6814303", "species_8848483" ], "modifiers": [ [ "species_10534904", "catalyst" ] ], "additional_components": [ "WBGene00016661" ] }, "reaction_10564918": { "compartment": "compartment_12045", "id": "reaction_10564918", "reactome": "R-CEL-8849353", "name": "Dynein drives COPI-independent retrograde traffic from the Golgi to the ER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10564872" ], "products": [ "species_29370", "species_10564859", "species_10553033", "species_10564898" ], "modifiers": [ [ "species_8848483", "catalyst" ], [ "species_10564916", "catalyst" ] ], "additional_components": [ "Q19020", "WBGene00000962", "O45087", "WBGene00015927", "Q65XS9", "WBGene00043067", "A0AAC1", "WBGene00012424", "Q7YTJ8", "WBGene00012425", "Q21557", "WBGene00010888", "Q22799", "WBGene00001005", "G5ED34", "WBGene00001007", "species_29420", "species_29438", "Q9NA98", "WBGene00013168", "P34685", "WBGene00000292", "P34686", "WBGene00000293", "Q18194", "WBGene00016124", "Q9N4I1", "WBGene00022118", "Q9N3F1", "WBGene00021827", "Q9GYR2", "WBGene00016793", "Q09248", "WBGene00001018", "E2JKZ0", "WBGene00001017", "V6CJ04", "WBGene00016611", "Q22782", "WBGene00004270", "P34213", "WBGene00004269", "Q8I136", "WBGene00001629", "O61394", "WBGene00001631", "V6CJ04", "WBGene00016611", "Q19020", "WBGene00000962", "O45087", "WBGene00015927", "Q65XS9", "WBGene00043067", "A0AAC1", "WBGene00012424", "Q7YTJ8", "WBGene00012425", "Q21557", "WBGene00010888", "Q22799", "WBGene00001005", "G5ED34", "WBGene00001007", "species_29420", "species_29438", "Q9NA98", "WBGene00013168", "P34685", "WBGene00000292", "P34686", "WBGene00000293", "Q18194", "WBGene00016124", "Q9N4I1", "WBGene00022118", "Q9N3F1", "WBGene00021827", "Q9GYR2", "WBGene00016793", "Q09248", "WBGene00001018", "E2JKZ0", "WBGene00001017", "O61394", "WBGene00001631", "Q8I136", "WBGene00001629", "P34213", "WBGene00004269", "Q22782", "WBGene00004270", "species_29438", "Q8MXS1", "WBGene00004277", "species_29438", "Q93538", "WBGene00004317", "Q22670", "WBGene00004318" ] }, "reaction_10564982": { "compartment": "compartment_12045", "id": "reaction_10564982", "reactome": "R-CEL-8850040", "name": "RAB3GAP1:RAB3GAP2 recruits RAB18:GCDP to ER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10564910", "species_10564978" ], "products": [ "species_10564980" ], "modifiers": [], "additional_components": [ "Q93538", "WBGene00004317", "Q22670", "WBGene00004318", "Q8MXS1", "WBGene00004277", "species_29420", "Q8MXS1", "WBGene00004277", "species_29420", "Q93538", "WBGene00004317", "Q22670", "WBGene00004318" ] }, "reaction_10564985": { "compartment": "compartment_12045", "id": "reaction_10564985", "reactome": "R-CEL-8850041", "name": "RAB3GAP1:RAB3GAP2 promotes nucleotide exchange on RAB18", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10564980" ], "products": [ "species_29420", "species_10564916" ], "modifiers": [ [ "species_10564980", "catalyst" ] ], "additional_components": [ "Q8MXS1", "WBGene00004277", "species_29420", "Q93538", "WBGene00004317", "Q22670", "WBGene00004318", "Q8MXS1", "WBGene00004277", "species_29438", "Q93538", "WBGene00004317", "Q22670", "WBGene00004318", "Q8MXS1", "WBGene00004277", "species_29420", "Q93538", "WBGene00004317", "Q22670", "WBGene00004318" ] }, "reaction_10564874": { "compartment": "compartment_20699", "id": "reaction_10564874", "reactome": "R-CEL-8849350", "name": "RAB6:GTP displaces PAFAH1B1 from dynein:dynactin complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10564861", "species_10564870" ], "products": [ "species_10564872", "species_10564868" ], "modifiers": [], "additional_components": [ "V6CJ04", "WBGene00016611", "Q22782", "WBGene00004270", "P34213", "WBGene00004269", "species_29438", "Q8I136", "WBGene00001629", "O61394", "WBGene00001631", "Q9NDC9", "WBGene00003047", "Q19020", "WBGene00000962", "O45087", "WBGene00015927", "Q65XS9", "WBGene00043067", "A0AAC1", "WBGene00012424", "Q7YTJ8", "WBGene00012425", "Q21557", "WBGene00010888", "Q22799", "WBGene00001005", "G5ED34", "WBGene00001007", "species_29420", "species_29438", "Q9NA98", "WBGene00013168", "P34685", "WBGene00000292", "P34686", "WBGene00000293", "Q18194", "WBGene00016124", "Q9N4I1", "WBGene00022118", "Q9N3F1", "WBGene00021827", "Q9GYR2", "WBGene00016793", "Q09248", "WBGene00001018", "E2JKZ0", "WBGene00001017", "Q19020", "WBGene00000962", "O45087", "WBGene00015927", "Q65XS9", "WBGene00043067", "A0AAC1", "WBGene00012424", "Q7YTJ8", "WBGene00012425", "Q21557", "WBGene00010888", "Q22799", "WBGene00001005", "G5ED34", "WBGene00001007", "species_29420", "species_29438", "Q9NA98", "WBGene00013168", "P34685", "WBGene00000292", "P34686", "WBGene00000293", "Q18194", "WBGene00016124", "Q9N4I1", "WBGene00022118", "Q9N3F1", "WBGene00021827", "Q9GYR2", "WBGene00016793", "Q09248", "WBGene00001018", "E2JKZ0", "WBGene00001017", "V6CJ04", "WBGene00016611", "Q22782", "WBGene00004270", "P34213", "WBGene00004269", "Q8I136", "WBGene00001629", "O61394", "WBGene00001631", "WBGene00003047" ] }, "reaction_10564863": { "compartment": "compartment_20699", "id": "reaction_10564863", "reactome": "R-CEL-8849348", "name": "RAB6:GTP and BICD homodimers bind COPI-independent Golgi-to-ER retrograde cargo", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10564846", "species_10564844", "species_10564859" ], "products": [ "species_10564861" ], "modifiers": [], "additional_components": [ "Q8I136", "WBGene00001629", "O61394", "WBGene00001631", "Q22782", "WBGene00004270", "P34213", "WBGene00004269", "species_29438", "V6CJ04", "WBGene00016611", "V6CJ04", "WBGene00016611", "Q22782", "WBGene00004270", "P34213", "WBGene00004269", "species_29438", "Q8I136", "WBGene00001629", "O61394", "WBGene00001631" ] }, "reaction_10563841": { "compartment": "compartment_20699", "id": "reaction_10563841", "reactome": "R-CEL-6811414", "name": "GBF1 stimulates nucleotide exchange on ARF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10563830" ], "products": [ "species_29420", "species_10563834" ], "modifiers": [ [ "species_10563830", "catalyst" ] ], "additional_components": [ "G5EGS5", "WBGene00007703", "Q9UAQ6", "WBGene00004266", "species_29438", "Q94231", "WBGene00000190", "species_29420", "G5EGS5", "WBGene00007703", "Q9UAQ6", "WBGene00004266", "species_29438", "Q94231", "WBGene00000190", "G5EGS5", "WBGene00007703", "Q9UAQ6", "WBGene00004266", "species_29438", "Q94231", "WBGene00000190", "species_29420" ] }, "reaction_10563843": { "compartment": "compartment_20699", "id": "reaction_10563843", "reactome": "R-CEL-6811415", "name": "RAB:GTP recruits GBF1 to the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10563535", "species_10563179" ], "products": [ "species_10563828" ], "modifiers": [], "additional_components": [ "Q9UAQ6", "WBGene00004266", "species_29438", "WBGene00007703", "G5EGS5", "WBGene00007703", "Q9UAQ6", "WBGene00004266", "species_29438" ] }, "reaction_10563890": { "compartment": "compartment_12045", "id": "reaction_10563890", "reactome": "R-CEL-6811422", "name": "NSF ATPase activity dissociates cis-SNARE at the ER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10563887", "species_113592" ], "products": [ "species_29372", "species_10563883", "species_10515624", "species_10563878", "species_10557345", "species_10557329", "species_10563873" ], "modifiers": [ [ "species_10563887", "catalyst" ] ], "additional_components": [ "Q18921", "WBGene00017016", "Q94392", "WBGene00003818", "Q94241", "WBGene00018853", "C0Z1Y7", "WBGene00018239", "O76413", "WBGene00020425", "Q9N598", "WBGene00022460", "WBGene00022460", "WBGene00018853", "WBGene00020425", "Q18921", "WBGene00017016", "Q94392", "WBGene00003818", "WBGene00018239", "Q18921", "WBGene00017016", "Q94392", "WBGene00003818", "Q94241", "WBGene00018853", "C0Z1Y7", "WBGene00018239", "O76413", "WBGene00020425", "Q9N598", "WBGene00022460" ] }, "reaction_10563832": { "compartment": "compartment_20699", "id": "reaction_10563832", "reactome": "R-CEL-6811411", "name": "GBF1 recruits ARF:GDP to the Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10563191", "species_10563828" ], "products": [ "species_10563830" ], "modifiers": [], "additional_components": [ "Q94231", "WBGene00000190", "species_29420", "G5EGS5", "WBGene00007703", "Q9UAQ6", "WBGene00004266", "species_29438", "G5EGS5", "WBGene00007703", "Q9UAQ6", "WBGene00004266", "species_29438", "Q94231", "WBGene00000190", "species_29420" ] }, "reaction_10563898": { "compartment": "compartment_12045", "id": "reaction_10563898", "reactome": "R-CEL-6811425", "name": "NSF and SNAPs bind cis-SNARE at the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10563896", "species_10557329", "species_10557345" ], "products": [ "species_10563887" ], "modifiers": [], "additional_components": [ "Q94241", "WBGene00018853", "C0Z1Y7", "WBGene00018239", "O76413", "WBGene00020425", "Q9N598", "WBGene00022460", "Q94392", "WBGene00003818", "Q18921", "WBGene00017016", "Q18921", "WBGene00017016", "Q94392", "WBGene00003818", "Q94241", "WBGene00018853", "C0Z1Y7", "WBGene00018239", "O76413", "WBGene00020425", "Q9N598", "WBGene00022460" ] }, "reaction_10563868": { "compartment": "compartment_20699", "id": "reaction_10563868", "reactome": "R-CEL-6811418", "name": "ARFGAPs stimulate ARF GTPase activity at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10563853" ], "products": [ "species_10563262", "species_10563179", "species_10563865", "species_10563191" ], "modifiers": [ [ "species_10563853", "catalyst" ] ], "additional_components": [ "Q94241", "WBGene00018853", "Q09473", "WBGene00016195", "P48583", "WBGene00001331", "Q18864", "WBGene00004788", "Q20546", "WBGene00009829", "A4F319", "WBGene00011606", "Q9U1Z4", "WBGene00013360", "O17528", "WBGene00004766", "O44738", "WBGene00019003", "G5EGS5", "WBGene00007703", "Q9UAQ6", "WBGene00004266", "species_29438", "Q94231", "WBGene00000190", "Q09236", "WBGene00015734", "Q22498", "WBGene00011775", "Q9TYL9", "WBGene00021292", "O17901", "WBGene00010333", "Q20168", "WBGene00009542", "O62246", "WBGene00009732", "Q9N4H7", "WBGene00022119", "Q09531", "WBGene00017217", "P90904", "WBGene00010500", "Q09531", "WBGene00017217", "P90904", "WBGene00010500", "WBGene00007703", "Q94241", "WBGene00018853", "Q9UAQ6", "WBGene00004266", "species_29438", "P48583", "WBGene00001331", "Q09473", "WBGene00016195", "Q18864", "WBGene00004788", "Q20546", "WBGene00009829", "Q9U1Z4", "WBGene00013360", "A4F319", "WBGene00011606", "O17528", "WBGene00004766", "O44738", "WBGene00019003", "Q09236", "WBGene00015734", "Q9TYL9", "WBGene00021292", "Q22498", "WBGene00011775", "O17901", "WBGene00010333", "Q9N4H7", "WBGene00022119", "Q20168", "WBGene00009542", "O62246", "WBGene00009732", "Q94231", "WBGene00000190", "species_29420", "Q94241", "WBGene00018853", "Q09473", "WBGene00016195", "P48583", "WBGene00001331", "Q18864", "WBGene00004788", "Q20546", "WBGene00009829", "A4F319", "WBGene00011606", "Q9U1Z4", "WBGene00013360", "O17528", "WBGene00004766", "O44738", "WBGene00019003", "G5EGS5", "WBGene00007703", "Q9UAQ6", "WBGene00004266", "species_29438", "Q94231", "WBGene00000190", "Q09236", "WBGene00015734", "Q22498", "WBGene00011775", "Q9TYL9", "WBGene00021292", "O17901", "WBGene00010333", "Q20168", "WBGene00009542", "O62246", "WBGene00009732", "Q9N4H7", "WBGene00022119", "Q09531", "WBGene00017217", "P90904", "WBGene00010500" ] }, "reaction_10563855": { "compartment": "compartment_20699", "id": "reaction_10563855", "reactome": "R-CEL-6811417", "name": "ARFGAP, cargo, vSNARES and p24 proteins bind COPI vesicles at Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10563262", "species_10563836", "species_10563565", "species_10563851", "species_10563845" ], "products": [ "species_10563853" ], "modifiers": [], "additional_components": [ "Q09531", "WBGene00017217", "P90904", "WBGene00010500", "G5EGS5", "WBGene00007703", "Q9UAQ6", "WBGene00004266", "species_29438", "Q94231", "WBGene00000190", "Q09236", "WBGene00015734", "Q22498", "WBGene00011775", "Q9TYL9", "WBGene00021292", "O17901", "WBGene00010333", "Q20168", "WBGene00009542", "O62246", "WBGene00009732", "Q9N4H7", "WBGene00022119", "O44738", "WBGene00019003", "Q20546", "WBGene00009829", "A4F319", "WBGene00011606", "Q9U1Z4", "WBGene00013360", "O17528", "WBGene00004766", "Q09473", "WBGene00016195", "P48583", "WBGene00001331", "Q18864", "WBGene00004788", "Q20546", "WBGene00009829", "A4F319", "WBGene00011606", "Q9U1Z4", "WBGene00013360", "O17528", "WBGene00004766", "WBGene00018853", "Q94241", "WBGene00018853", "Q09473", "WBGene00016195", "P48583", "WBGene00001331", "Q18864", "WBGene00004788", "Q20546", "WBGene00009829", "A4F319", "WBGene00011606", "Q9U1Z4", "WBGene00013360", "O17528", "WBGene00004766", "O44738", "WBGene00019003", "G5EGS5", "WBGene00007703", "Q9UAQ6", "WBGene00004266", "species_29438", "Q94231", "WBGene00000190", "Q09236", "WBGene00015734", "Q22498", "WBGene00011775", "Q9TYL9", "WBGene00021292", "O17901", "WBGene00010333", "Q20168", "WBGene00009542", "O62246", "WBGene00009732", "Q9N4H7", "WBGene00022119", "Q09531", "WBGene00017217", "P90904", "WBGene00010500" ] }, "reaction_10563838": { "compartment": "compartment_20699", "id": "reaction_10563838", "reactome": "R-CEL-6811412", "name": "Active ARF recruits coatomer to the Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10563244", "species_10563834" ], "products": [ "species_10563836" ], "modifiers": [], "additional_components": [ "Q09236", "WBGene00015734", "Q22498", "WBGene00011775", "Q9TYL9", "WBGene00021292", "O17901", "WBGene00010333", "Q20168", "WBGene00009542", "O62246", "WBGene00009732", "Q9N4H7", "WBGene00022119", "G5EGS5", "WBGene00007703", "Q9UAQ6", "WBGene00004266", "species_29438", "Q94231", "WBGene00000190", "G5EGS5", "WBGene00007703", "Q9UAQ6", "WBGene00004266", "species_29438", "Q94231", "WBGene00000190", "Q09236", "WBGene00015734", "Q22498", "WBGene00011775", "Q9TYL9", "WBGene00021292", "O17901", "WBGene00010333", "Q20168", "WBGene00009542", "O62246", "WBGene00009732", "Q9N4H7", "WBGene00022119" ] }, "reaction_10563982": { "compartment": "compartment_12045", "id": "reaction_10563982", "reactome": "R-CEL-6811427", "name": "COPI vesicle uncoating at the ER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10563980" ], "products": [ "species_10557214", "species_10563244", "species_10563978", "species_10563896", "species_10563936" ], "modifiers": [], "additional_components": [ "Q20546", "WBGene00009829", "O17528", "WBGene00004766", "O44738", "WBGene00019003", "A4F319", "WBGene00011606", "Q9U1Z4", "WBGene00013360", "Q94241", "WBGene00018853", "Q19642", "WBGene00017643", "P90841", "WBGene00008990", "Q9N4H7", "WBGene00022119", "Q20168", "WBGene00009542", "O62246", "WBGene00009732", "Q22498", "WBGene00011775", "O17901", "WBGene00010333", "Q09236", "WBGene00015734", "Q9TYL9", "WBGene00021292", "P48583", "WBGene00001331", "Q09473", "WBGene00016195", "Q18864", "WBGene00004788", "C0Z1Y7", "WBGene00018239", "O76413", "WBGene00020425", "Q9N598", "WBGene00022460", "Q9UAQ6", "WBGene00004266", "species_29438", "Q9UAQ6", "WBGene00004266", "species_29420", "Q09236", "WBGene00015734", "Q22498", "WBGene00011775", "Q9TYL9", "WBGene00021292", "O17901", "WBGene00010333", "Q20168", "WBGene00009542", "O62246", "WBGene00009732", "Q9N4H7", "WBGene00022119", "P48583", "WBGene00001331", "Q09473", "WBGene00016195", "Q20546", "WBGene00009829", "O17528", "WBGene00004766", "Q18864", "WBGene00004788", "A4F319", "WBGene00011606", "Q9U1Z4", "WBGene00013360", "Q94241", "WBGene00018853", "C0Z1Y7", "WBGene00018239", "O76413", "WBGene00020425", "Q9N598", "WBGene00022460", "Q20546", "WBGene00009829", "O17528", "WBGene00004766", "O44738", "WBGene00019003", "A4F319", "WBGene00011606", "Q9U1Z4", "WBGene00013360" ] }, "reaction_10555089": { "compartment": "compartment_876", "id": "reaction_10555089", "reactome": "R-CEL-5672980", "name": "Dissociation of RAS:RAF complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10555069" ], "products": [ "species_10555065", "species_10555030", "species_10508583", "species_10555044" ], "modifiers": [], "additional_components": [ "P39745", "WBGene00003401", "Q10664", "WBGene00003186", "Q07292", "WBGene00003030", "species_29438", "P22981", "WBGene00002335", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "Q10664", "WBGene00003186", "WBGene00003401", "Q07292", "WBGene00003030", "species_29438", "P22981", "WBGene00002335", "P41932", "WBGene00003920", "Q20655", "WBGene00001502" ] }, "reaction_10572917": { "compartment": "compartment_876", "id": "reaction_10572917", "reactome": "R-CEL-9657599", "name": "Dual mechanism MAP2K inhibitors bind MAP2Ks", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9657567", "species_10555042" ], "products": [ "species_10555074" ], "modifiers": [], "additional_components": [ "Q10664", "WBGene00003186", "Q07292", "WBGene00003030", "species_29438", "P22981", "WBGene00002335", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "P39745", "WBGene00003401", "Q10664", "WBGene00003186", "Q07292", "WBGene00003030", "species_29438", "P22981", "WBGene00002335", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "P39745", "WBGene00003401" ] }, "reaction_10555156": { "compartment": "compartment_20699", "id": "reaction_10555156", "reactome": "R-CEL-5674366", "name": "IL17RD binds p-2S MAP2Ks and MAPKs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508575", "species_10555065", "species_10555152" ], "products": [ "species_10555154" ], "modifiers": [], "additional_components": [ "WBGene00003401", "Q10664", "WBGene00003186", "Q10128", "WBGene00018960", "Q9NA64", "WBGene00013415", "Q10128", "WBGene00018960", "Q9NA64", "WBGene00013415", "Q10664", "WBGene00003186", "P39745", "WBGene00003401" ] }, "reaction_10572919": { "compartment": "compartment_876", "id": "reaction_10572919", "reactome": "R-CEL-9657603", "name": "Dual mechanism MAPK inhibitors bind MAPKs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10555067", "species_9657570" ], "products": [ "species_10555076" ], "modifiers": [], "additional_components": [ "Q10664", "WBGene00003186", "Q07292", "WBGene00003030", "species_29438", "P22981", "WBGene00002335", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "P39745", "WBGene00003401", "Q10664", "WBGene00003186", "Q07292", "WBGene00003030", "species_29438", "P22981", "WBGene00002335", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "P39745", "WBGene00003401" ] }, "reaction_10555078": { "compartment": "compartment_876", "id": "reaction_10555078", "reactome": "R-CEL-5672973", "name": "MAP2Ks phosphorylate MAPKs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10555067", "species_113592" ], "products": [ "species_10555069", "species_29370" ], "modifiers": [ [ "species_10555067", "catalyst" ], [ "species_10555074", "inhibitor" ], [ "species_10555076", "inhibitor" ], [ "species_10555072", "inhibitor" ] ], "additional_components": [ "Q10664", "WBGene00003186", "Q07292", "WBGene00003030", "species_29438", "P22981", "WBGene00002335", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "P39745", "WBGene00003401", "P39745", "WBGene00003401", "Q10664", "WBGene00003186", "Q07292", "WBGene00003030", "species_29438", "P22981", "WBGene00002335", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "Q10664", "WBGene00003186", "Q07292", "WBGene00003030", "species_29438", "P22981", "WBGene00002335", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "P39745", "WBGene00003401", "Q10664", "WBGene00003186", "Q07292", "WBGene00003030", "species_29438", "P22981", "WBGene00002335", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "P39745", "WBGene00003401", "Q10664", "WBGene00003186", "Q07292", "WBGene00003030", "species_29438", "P22981", "WBGene00002335", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "P39745", "WBGene00003401", "Q10664", "WBGene00003186", "Q07292", "WBGene00003030", "species_29438", "P22981", "WBGene00002335", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "P39745", "WBGene00003401" ] }, "reaction_10572921": { "compartment": "compartment_876", "id": "reaction_10572921", "reactome": "R-CEL-9657606", "name": "Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10555067", "species_9657574" ], "products": [ "species_10555072" ], "modifiers": [], "additional_components": [ "Q10664", "WBGene00003186", "Q07292", "WBGene00003030", "species_29438", "P22981", "WBGene00002335", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "P39745", "WBGene00003401", "Q10664", "WBGene00003186", "Q07292", "WBGene00003030", "species_29438", "P22981", "WBGene00002335", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "P39745", "WBGene00003401" ] }, "reaction_10555129": { "compartment": "compartment_74700", "id": "reaction_10555129", "reactome": "R-CEL-5674130", "name": "MAP2Ks and MAPKs are phosphorylated at the endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10555125" ], "products": [ "species_29370", "species_10555127" ], "modifiers": [], "additional_components": [ "Q19986", "WBGene00018014", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "Q10664", "WBGene00003186", "Q07292", "WBGene00003030", "P39745", "WBGene00003401", "Q19986", "WBGene00018014", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "Q07292", "WBGene00003030", "P39745", "WBGene00003401", "Q10664", "WBGene00003186" ] }, "reaction_10555161": { "compartment": "compartment_20699", "id": "reaction_10555161", "reactome": "R-CEL-5674373", "name": "MAP2Ks phosphorylate MAPK at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10555154" ], "products": [ "species_29370", "species_10555158" ], "modifiers": [ [ "species_10555154", "catalyst" ] ], "additional_components": [ "Q10128", "WBGene00018960", "Q9NA64", "WBGene00013415", "Q10664", "WBGene00003186", "P39745", "WBGene00003401", "Q10128", "WBGene00018960", "Q9NA64", "WBGene00013415", "P39745", "WBGene00003401", "Q10664", "WBGene00003186", "Q10128", "WBGene00018960", "Q9NA64", "WBGene00013415", "Q10664", "WBGene00003186", "P39745", "WBGene00003401" ] }, "reaction_10555131": { "compartment": "compartment_74700", "id": "reaction_10555131", "reactome": "R-CEL-5674132", "name": "WDR83:LAMTOR2:LAMTOR3 binds MAPK components", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508575", "species_10555123", "species_10555040", "species_10555121" ], "products": [ "species_10555125" ], "modifiers": [], "additional_components": [ "WBGene00003401", "Q07292", "WBGene00003030", "Q10664", "WBGene00003186", "Q19986", "WBGene00018014", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "Q19986", "WBGene00018014", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "Q10664", "WBGene00003186", "Q07292", "WBGene00003030", "P39745", "WBGene00003401" ] }, "reaction_10555053": { "compartment": "compartment_876", "id": "reaction_10555053", "reactome": "R-CEL-5672972", "name": "MAP2Ks and MAPKs bind to the activated RAF complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508575", "species_10555006", "species_10555030", "species_10555040" ], "products": [ "species_10555042" ], "modifiers": [ [ "species_10555051", "inhibitor" ] ], "additional_components": [ "WBGene00003401", "Q07292", "WBGene00003030", "species_29438", "P22981", "WBGene00002335", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "Q10664", "WBGene00003186", "Q10664", "WBGene00003186", "Q07292", "WBGene00003030", "species_29438", "P22981", "WBGene00002335", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "P39745", "WBGene00003401", "Q07292", "WBGene00003030", "species_29438", "P22981", "WBGene00002335", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "O16264", "WBGene00018218" ] }, "reaction_10572925": { "compartment": "compartment_876", "id": "reaction_10572925", "reactome": "R-CEL-9657608", "name": "Single mechanism MAPK inhibitors bind phosphorylated MAPK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10555069", "species_9657577" ], "products": [ "species_10572923" ], "modifiers": [], "additional_components": [ "P39745", "WBGene00003401", "Q10664", "WBGene00003186", "Q07292", "WBGene00003030", "species_29438", "P22981", "WBGene00002335", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "P39745", "WBGene00003401", "Q10664", "WBGene00003186", "Q07292", "WBGene00003030", "species_29438", "P22981", "WBGene00002335", "P41932", "WBGene00003920", "Q20655", "WBGene00001502" ] }, "reaction_10555086": { "compartment": "compartment_876", "id": "reaction_10555086", "reactome": "R-CEL-5672978", "name": "RAF phosphorylates MAP2K dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10555042" ], "products": [ "species_10555067", "species_29370" ], "modifiers": [ [ "species_10555042", "catalyst" ], [ "species_10555084", "inhibitor" ], [ "species_10555074", "inhibitor" ] ], "additional_components": [ "Q10664", "WBGene00003186", "Q07292", "WBGene00003030", "species_29438", "P22981", "WBGene00002335", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "P39745", "WBGene00003401", "Q10664", "WBGene00003186", "Q07292", "WBGene00003030", "species_29438", "P22981", "WBGene00002335", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "P39745", "WBGene00003401", "Q10664", "WBGene00003186", "Q07292", "WBGene00003030", "species_29438", "P22981", "WBGene00002335", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "P39745", "WBGene00003401", "Q07292", "WBGene00003030", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "species_29438", "P22981", "WBGene00002335", "Q10664", "WBGene00003186", "Q07292", "WBGene00003030", "species_29438", "P22981", "WBGene00002335", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "P39745", "WBGene00003401" ] }, "reaction_10534928": { "compartment": "compartment_12045", "id": "reaction_10534928", "reactome": "R-CEL-1482900", "name": "PG is hydrolyzed to 1-acyl LPG by PLA2[1]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1483256", "species_29356" ], "products": [ "species_1524021", "species_1498740" ], "modifiers": [ [ "species_10534783", "catalyst" ] ], "additional_components": [ "O16654", "WBGene00044468", "Q17790", "WBGene00044468", "Q3V5J7", "WBGene00044468" ] }, "reaction_10535857": { "compartment": "compartment_984", "id": "reaction_10535857", "reactome": "R-CEL-1602368", "name": "PG is hydrolyzed to 1-acyl LPG by PLA2[16]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_1602402" ], "products": [ "species_1602415", "species_1602366" ], "modifiers": [ [ "species_10535837", "catalyst" ], [ "species_10535855", "inhibitor" ] ], "additional_components": [ "species_74016", "Q17790", "WBGene00044468", "O16654", "WBGene00044468", "Q3V5J7", "WBGene00044468", "Q18339", "WBGene00016288", "G4RY15", "WBGene00015631", "P34472", "WBGene00010228", "Q22591", "WBGene00020585" ] }, "reaction_10534930": { "compartment": "compartment_12045", "id": "reaction_10534930", "reactome": "R-CEL-1482907", "name": "PG is hydrolyzed to 1-acyl LPG by PLA2G2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1483256", "species_29356" ], "products": [ "species_1524021", "species_1498740" ], "modifiers": [ [ "species_10534852", "catalyst" ] ], "additional_components": [ "Q3V5J7", "WBGene00044468", "O16654", "WBGene00044468", "Q17790", "WBGene00044468", "species_74016" ] }, "reaction_10534742": { "compartment": "compartment_12045", "id": "reaction_10534742", "reactome": "R-CEL-1482539", "name": "1-acyl LPG is acylated to PG by LPGAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500578", "species_1498740" ], "products": [ "species_1483256", "species_76194" ], "modifiers": [ [ "species_10534739", "catalyst" ] ], "additional_components": [ "WBGene00019465" ] }, "reaction_10534792": { "compartment": "compartment_12045", "id": "reaction_10534792", "reactome": "R-CEL-1482635", "name": "2-acyl LPG is acylated to PG by LPGAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1498730", "species_1500578" ], "products": [ "species_1483256", "species_76194" ], "modifiers": [ [ "species_10534739", "catalyst" ] ], "additional_components": [ "WBGene00019465" ] }, "reaction_10534858": { "compartment": "compartment_70616", "id": "reaction_10534858", "reactome": "R-CEL-1482689", "name": "1-acyl LPG is acylated to PG by CRLS1 (IM)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524027", "species_1524038" ], "products": [ "species_29374", "species_1524042" ], "modifiers": [ [ "species_10534747", "catalyst" ] ], "additional_components": [ "WBGene00017763" ] }, "reaction_10534750": { "compartment": "compartment_70616", "id": "reaction_10534750", "reactome": "R-CEL-1482546", "name": "2-acyl LPG is acylated to PG by CRLS1 (IM)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524047", "species_1524038" ], "products": [ "species_29374", "species_1524042" ], "modifiers": [ [ "species_10534747", "catalyst" ] ], "additional_components": [ "WBGene00017763" ] }, "reaction_10565132": { "compartment": "compartment_70101", "id": "reaction_10565132", "reactome": "R-CEL-8851827", "name": "RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10512175", "species_29438" ], "products": [ "species_29420", "species_10511481" ], "modifiers": [ [ "species_10554985", "catalyst" ] ], "additional_components": [ "species_29420", "P22981", "WBGene00002335", "species_29438", "P22981", "WBGene00002335", "Q9XVQ7", "WBGene00008711", "P29355", "WBGene00004774", "Q9N5D3", "WBGene00004947" ] }, "reaction_10565135": { "compartment": "compartment_70101", "id": "reaction_10565135", "reactome": "R-CEL-8851877", "name": "RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10512175", "species_29438" ], "products": [ "species_29420", "species_10511481" ], "modifiers": [ [ "species_10554983", "catalyst" ] ], "additional_components": [ "species_29420", "P22981", "WBGene00002335", "species_29438", "P22981", "WBGene00002335", "Q9XWK4", "WBGene00013202", "Q9XVQ7", "WBGene00008711", "Q9N5D3", "WBGene00004947" ] }, "reaction_10550976": { "compartment": "compartment_7660", "id": "reaction_10550976", "reactome": "R-CEL-5244669", "name": "CDK1 phosphorylates lamins and facilitates depolymerization of lamin filaments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10550899" ], "products": [ "species_113582", "species_10550974" ], "modifiers": [ [ "species_10511241", "catalyst" ] ], "additional_components": [ "Q19782", "WBGene00002058", "P90900", "WBGene00002052", "Q21065", "WBGene00002051", "P90901", "WBGene00002050", "Q21067", "WBGene00002056", "Q09501", "WBGene00002067", "Q21443", "WBGene00003052", "Q19286", "WBGene00002054", "O02365", "WBGene00003485", "Q86DC6", "WBGene00002057", "Q19289", "WBGene00002053", "O45168", "WBGene00002055", "P90900", "WBGene00002052", "Q21443", "WBGene00003052", "P90901", "WBGene00002050", "Q86DC6", "WBGene00002057", "Q09501", "WBGene00002067", "Q19286", "WBGene00002054", "Q19289", "WBGene00002053", "Q19782", "WBGene00002058", "O02365", "WBGene00003485", "Q21065", "WBGene00002051", "O45168", "WBGene00002055", "Q21067", "WBGene00002056", "O45926", "WBGene00000866", "Q10653", "WBGene00000865", "Q9BLB5", "WBGene00000867", "P34556", "WBGene00000405" ] }, "reaction_10550709": { "compartment": "compartment_13231", "id": "reaction_10550709", "reactome": "R-CEL-5221130", "name": "LPIN catalyzes conversion of phosphatidic acid to diacylglycerol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_5221122" ], "products": [ "species_113550", "species_5221124" ], "modifiers": [ [ "species_10549162", "catalyst" ] ], "additional_components": [ "WBGene00010425" ] }, "reaction_10550349": { "compartment": "compartment_7660", "id": "reaction_10550349", "reactome": "R-CEL-5195402", "name": "CDK1 phosphorylates LPIN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10549162" ], "products": [ "species_113582", "species_10549156" ], "modifiers": [ [ "species_10511241", "catalyst" ] ], "additional_components": [ "WBGene00010425", "WBGene00010425", "O45926", "WBGene00000866", "Q10653", "WBGene00000865", "Q9BLB5", "WBGene00000867", "P34556", "WBGene00000405" ] }, "reaction_10549181": { "compartment": "compartment_13231", "id": "reaction_10549181", "reactome": "R-CEL-4419948", "name": "CTDNEP1:CNEP1R1 dephosphorylates LPIN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10549156" ], "products": [ "species_113550", "species_10549162" ], "modifiers": [ [ "species_10549178", "catalyst" ] ], "additional_components": [ "WBGene00010425", "WBGene00010425", "Q20432", "WBGene00018474", "Q9XXN3", "WBGene00011828" ] }, "reaction_10550717": { "compartment": "compartment_13231", "id": "reaction_10550717", "reactome": "R-CEL-5223304", "name": "DAG and Ca+2 bind to PKC and tether it to membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5221124", "species_29496", "species_10550711" ], "products": [ "species_10550715" ], "modifiers": [], "additional_components": [ "WBGene00004033", "P90980", "WBGene00004033", "species_74016", "species_114519" ] }, "reaction_10520494": { "compartment": "compartment_70101", "id": "reaction_10520494", "reactome": "R-CEL-388824", "name": "PTPRF, PTPRS, PTPRD bind Liprins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10520490", "species_10520454" ], "products": [ "species_10520492" ], "modifiers": [], "additional_components": [ "O01736", "WBGene00044348", "Q9BMN8", "WBGene00004215", "O17889", "WBGene00044348", "W6RR46", "WBGene00044348", "Q22852", "WBGene00044348", "Q95Y26", "WBGene00044348", "Q21049", "WBGene00006364", "Q94071", "WBGene00011904", "Q21049", "WBGene00006364", "Q94071", "WBGene00011904", "O01736", "WBGene00044348", "Q9BMN8", "WBGene00004215", "O17889", "WBGene00044348", "W6RR46", "WBGene00044348", "Q22852", "WBGene00044348", "Q95Y26", "WBGene00044348" ] }, "reaction_10559201": { "compartment": "compartment_876", "id": "reaction_10559201", "reactome": "R-CEL-6794346", "name": "NRXNs bind NLGNs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10559197", "species_10559159" ], "products": [ "species_10559199" ], "modifiers": [], "additional_components": [ "Q20826", "WBGene00018878", "Q9XTG1", "WBGene00006412", "I2HAJ6", "WBGene00007799", "O45000", "WBGene00002174", "I2HAJ6", "WBGene00007799", "O45000", "WBGene00002174", "Q20826", "WBGene00018878", "Q9XTG1", "WBGene00006412" ] }, "reaction_10559280": { "compartment": "compartment_876", "id": "reaction_10559280", "reactome": "R-CEL-6797554", "name": "ABP1 binds SHANK proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10515342", "species_10559276" ], "products": [ "species_10559278" ], "modifiers": [], "additional_components": [ "WBGene00010664", "G5ECY0", "WBGene00001006", "Q22638", "WBGene00011890", "I2HAJ6", "WBGene00007799", "O45000", "WBGene00002174", "Q20826", "WBGene00018878", "Q9XTG1", "WBGene00006412", "B7WN72", "WBGene00006444", "G5ECY0", "WBGene00001006", "Q22638", "WBGene00011890", "I2HAJ6", "WBGene00007799", "O45000", "WBGene00002174", "Q20826", "WBGene00018878", "Q9XTG1", "WBGene00006412", "B7WN72", "WBGene00006444", "Q9XUT0", "WBGene00010664" ] }, "reaction_10559284": { "compartment": "compartment_876", "id": "reaction_10559284", "reactome": "R-CEL-6797568", "name": "NRXNs bind CASK:Protein 4.1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10559199", "species_10559241" ], "products": [ "species_10559282" ], "modifiers": [], "additional_components": [ "I2HAJ6", "WBGene00007799", "O45000", "WBGene00002174", "Q20826", "WBGene00018878", "Q9XTG1", "WBGene00006412", "P54936", "WBGene00002991", "H2KZV9", "WBGene00001489", "G5EEG8", "WBGene00001488", "P54936", "WBGene00002991", "H2KZV9", "WBGene00001489", "G5EEG8", "WBGene00001488", "I2HAJ6", "WBGene00007799", "O45000", "WBGene00002174", "Q20826", "WBGene00018878", "Q9XTG1", "WBGene00006412" ] }, "reaction_10559243": { "compartment": "compartment_70101", "id": "reaction_10559243", "reactome": "R-CEL-6797553", "name": "Protein 4.1 binds CASK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10559239", "species_10519878" ], "products": [ "species_10559241" ], "modifiers": [], "additional_components": [ "H2KZV9", "WBGene00001489", "G5EEG8", "WBGene00001488", "WBGene00002991", "P54936", "WBGene00002991", "H2KZV9", "WBGene00001489", "G5EEG8", "WBGene00001488" ] }, "reaction_10564964": { "compartment": "compartment_876", "id": "reaction_10564964", "reactome": "R-CEL-8849878", "name": "PSD-95 binds NMDA receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10564960", "species_10523840" ], "products": [ "species_10564962" ], "modifiers": [], "additional_components": [ "G5EEH3", "WBGene00003775", "G5EGQ9", "WBGene00003774", "species_159549", "species_113552", "G5ECY0", "WBGene00001006", "Q22638", "WBGene00011890", "G5ECY0", "WBGene00001006", "Q22638", "WBGene00011890", "G5EEH3", "WBGene00003775", "G5EGQ9", "WBGene00003774", "species_159549", "species_113552" ] }, "reaction_10552287": { "compartment": "compartment_5460", "id": "reaction_10552287", "reactome": "R-CEL-5419261", "name": "55S ribosome with peptidyl-tRNA in A site binds GFM1:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10552283", "species_10552276" ], "products": [ "species_10552285" ], "modifiers": [], "additional_components": [ "species_29438", "Q9XV52", "WBGene00009246", "Q93425", "WBGene00008452", "Q9U3Q0", "WBGene00007564", "O61791", "WBGene00020037", "P34748", "WBGene00014224", "Q95Q11", "WBGene00013324", "Q688C0", "WBGene00023487", "P34388", "WBGene00017319", "Q9N361", "WBGene00021920", "Q95QS3", "WBGene00016412", "Q9XWV5", "WBGene00012556", "G5ECC9", "WBGene00010766", "Q22470", "WBGene00011759", "Q22483", "WBGene00020499", "Q9XWP0", "WBGene00012830", "G5EC67", "WBGene00013210", "Q23155", "WBGene00012244", "Q9XTY5", "WBGene00011391", "O61818", "WBGene00044321", "O44133", "WBGene00016057", "Q09261", "WBGene00007859", "G5EFC8", "WBGene00000933", "P49391", "WBGene00011334", "Q9NAP9", "WBGene00010624", "Q19685", "WBGene00009013", "Q9N584", "WBGene00002804", "Q21601", "WBGene00010905", "Q10129", "WBGene00018961", "O17004", "WBGene00020718", "Q11189", "WBGene00015487", "Q9NEI6", "WBGene00012697", "Q09523", "WBGene00008456", "Q9GYI2", "WBGene00017924", "Q21454", "WBGene00010812", "O02207", "WBGene00007215", "Q04907", "WBGene00016249", "Q95QC2", "WBGene00019838", "Q9UA63", "WBGene00021021", "P34384", "WBGene00008514", "Q9BPN6", "WBGene00022373", "O02220", "WBGene00007712", "Q95QL2", "WBGene00008769", "A0A1N7SYX2", "WBGene00003066", "O18180", "WBGene00012361", "P90993", "WBGene00015185", "P34264", "WBGene00015133", "Q9TZ90", "WBGene00018793", "Q21083", "WBGene00010458", "O17005", "WBGene00020717", "Q7KPW7", "WBGene00017997", "Q4W5T0", "WBGene00044344", "Q22623", "WBGene00011883", "Q9NAG2", "WBGene00012992", "Q21939", "WBGene00011247", "O45110", "WBGene00018932", "O44159", "WBGene00016989", "Q95Y83", "WBGene00022470", "Q2L6V2", "WBGene00015092", "P34378", "WBGene00017044", "C0VXV6", "WBGene00021935", "Q9N3F3", "WBGene00021829", "Q95Y71", "WBGene00022493", "Q22140", "WBGene00011412", "P90915", "WBGene00010616", "P49404", "WBGene00016142", "Q95X39", "WBGene00015025", "O76606", "WBGene00020796", "Q9TYJ8", "WBGene00022045", "P91353", "WBGene00019076", "O17839", "WBGene00009128", "Q9GYS9", "WBGene00020348", "Q7YX52", "WBGene00008459", "Q9XX18", "WBGene00012645", "Q22438", "WBGene00011740", "Q6A575", "WBGene00023422", "Q7YWY8", "WBGene00010783", "O18199", "WBGene00013004", "Q93425", "WBGene00008452", "Q9U3Q0", "WBGene00007564", "O61791", "WBGene00020037", "P34748", "WBGene00014224", "Q95Q11", "WBGene00013324", "Q688C0", "WBGene00023487", "P34388", "WBGene00017319", "Q9N361", "WBGene00021920", "Q95QS3", "WBGene00016412", "Q9XWV5", "WBGene00012556", "G5ECC9", "WBGene00010766", "Q22470", "WBGene00011759", "Q22483", "WBGene00020499", "Q9XWP0", "WBGene00012830", "G5EC67", "WBGene00013210", "Q23155", "WBGene00012244", "Q9XTY5", "WBGene00011391", "O61818", "WBGene00044321", "O44133", "WBGene00016057", "Q09261", "WBGene00007859", "G5EFC8", "WBGene00000933", "P49391", "WBGene00011334", "Q9NAP9", "WBGene00010624", "Q19685", "WBGene00009013", "Q9N584", "WBGene00002804", "Q21601", "WBGene00010905", "Q10129", "WBGene00018961", "O17004", "WBGene00020718", "Q11189", "WBGene00015487", "Q9NEI6", "WBGene00012697", "Q09523", "WBGene00008456", "Q9GYI2", "WBGene00017924", "Q21454", "WBGene00010812", "O02207", "WBGene00007215", "Q04907", "WBGene00016249", "Q95QC2", "WBGene00019838", "Q9UA63", "WBGene00021021", "P34384", "WBGene00008514", "Q9BPN6", "WBGene00022373", "O02220", "WBGene00007712", "Q95QL2", "WBGene00008769", "A0A1N7SYX2", "WBGene00003066", "O18180", "WBGene00012361", "P90993", "WBGene00015185", "P34264", "WBGene00015133", "Q9TZ90", "WBGene00018793", "Q21083", "WBGene00010458", "O17005", "WBGene00020717", "Q7KPW7", "WBGene00017997", "Q4W5T0", "WBGene00044344", "Q22623", "WBGene00011883", "Q9NAG2", "WBGene00012992", "Q21939", "WBGene00011247", "O45110", "WBGene00018932", "O44159", "WBGene00016989", "Q95Y83", "WBGene00022470", "Q2L6V2", "WBGene00015092", "P34378", "WBGene00017044", "C0VXV6", "WBGene00021935", "Q9N3F3", "WBGene00021829", "Q95Y71", "WBGene00022493", "Q22140", "WBGene00011412", "P90915", "WBGene00010616", "P49404", "WBGene00016142", "Q95X39", "WBGene00015025", "O76606", "WBGene00020796", "Q9TYJ8", "WBGene00022045", "P91353", "WBGene00019076", "O17839", "WBGene00009128", "Q9GYS9", "WBGene00020348", "Q7YX52", "WBGene00008459", "Q9XX18", "WBGene00012645", "Q22438", "WBGene00011740", "Q6A575", "WBGene00023422", "Q7YWY8", "WBGene00010783", "O18199", "WBGene00013004", "species_29438", "Q9XV52", "WBGene00009246" ] }, "reaction_10552308": { "compartment": "compartment_5460", "id": "reaction_10552308", "reactome": "R-CEL-5419271", "name": "55S ribosome hydrolyzes peptidyl-tRNA bond and MTRF1L hydrolyzes GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10552300" ], "products": [ "species_113548", "species_10552298", "species_5419287", "species_113525", "species_10552306" ], "modifiers": [], "additional_components": [ "Q93425", "WBGene00008452", "Q9U3Q0", "WBGene00007564", "O61791", "WBGene00020037", "P34748", "WBGene00014224", "Q95Q11", "WBGene00013324", "Q688C0", "WBGene00023487", "P34388", "WBGene00017319", "Q9N361", "WBGene00021920", "Q95QS3", "WBGene00016412", "Q9XWV5", "WBGene00012556", "G5ECC9", "WBGene00010766", "Q22470", "WBGene00011759", "Q22483", "WBGene00020499", "Q9XWP0", "WBGene00012830", "G5EC67", "WBGene00013210", "Q23155", "WBGene00012244", "Q9XTY5", "WBGene00011391", "O61818", "WBGene00044321", "O44133", "WBGene00016057", "Q09261", "WBGene00007859", "G5EFC8", "WBGene00000933", "P49391", "WBGene00011334", "Q9NAP9", "WBGene00010624", "Q19685", "WBGene00009013", "Q9N584", "WBGene00002804", "Q21601", "WBGene00010905", "Q10129", "WBGene00018961", "O17004", "WBGene00020718", "Q11189", "WBGene00015487", "Q9NEI6", "WBGene00012697", "Q09523", "WBGene00008456", "Q9GYI2", "WBGene00017924", "Q21454", "WBGene00010812", "O02207", "WBGene00007215", "Q04907", "WBGene00016249", "Q95QC2", "WBGene00019838", "Q9UA63", "WBGene00021021", "P34384", "WBGene00008514", "Q9BPN6", "WBGene00022373", "O02220", "WBGene00007712", "Q95QL2", "WBGene00008769", "A0A1N7SYX2", "WBGene00003066", "O18180", "WBGene00012361", "P90993", "WBGene00015185", "P34264", "WBGene00015133", "Q9TZ90", "WBGene00018793", "Q21083", "WBGene00010458", "O17005", "WBGene00020717", "Q7KPW7", "WBGene00017997", "Q4W5T0", "WBGene00044344", "Q22623", "WBGene00011883", "Q9NAG2", "WBGene00012992", "Q21939", "WBGene00011247", "O45110", "WBGene00018932", "O44159", "WBGene00016989", "Q95Y83", "WBGene00022470", "Q2L6V2", "WBGene00015092", "P34378", "WBGene00017044", "C0VXV6", "WBGene00021935", "Q9N3F3", "WBGene00021829", "Q95Y71", "WBGene00022493", "Q22140", "WBGene00011412", "P90915", "WBGene00010616", "P49404", "WBGene00016142", "Q95X39", "WBGene00015025", "O76606", "WBGene00020796", "Q9TYJ8", "WBGene00022045", "P91353", "WBGene00019076", "O17839", "WBGene00009128", "Q9GYS9", "WBGene00020348", "Q7YX52", "WBGene00008459", "Q9XX18", "WBGene00012645", "Q22438", "WBGene00011740", "Q6A575", "WBGene00023422", "Q7YWY8", "WBGene00010783", "O18199", "WBGene00013004", "species_29438", "O44568", "WBGene00020993", "O44568", "WBGene00020993", "Q95QC2", "WBGene00019838", "Q93425", "WBGene00008452", "Q9U3Q0", "WBGene00007564", "O61791", "WBGene00020037", "P34748", "WBGene00014224", "Q95Q11", "WBGene00013324", "Q688C0", "WBGene00023487", "P34388", "WBGene00017319", "Q9N361", "WBGene00021920", "Q95QS3", "WBGene00016412", "Q9XWV5", "WBGene00012556", "G5ECC9", "WBGene00010766", "Q22470", "WBGene00011759", "Q22483", "WBGene00020499", "Q9XWP0", "WBGene00012830", "G5EC67", "WBGene00013210", "Q23155", "WBGene00012244", "Q9XTY5", "WBGene00011391", "O61818", "WBGene00044321", "O44133", "WBGene00016057", "Q09261", "WBGene00007859", "G5EFC8", "WBGene00000933", "P49391", "WBGene00011334", "Q9NAP9", "WBGene00010624", "Q19685", "WBGene00009013", "Q9N584", "WBGene00002804", "Q21601", "WBGene00010905", "Q10129", "WBGene00018961", "O17004", "WBGene00020718", "Q11189", "WBGene00015487", "Q9NEI6", "WBGene00012697", "Q09523", "WBGene00008456", "Q9GYI2", "WBGene00017924", "Q21454", "WBGene00010812", "O02207", "WBGene00007215", "Q04907", "WBGene00016249", "Q95QC2", "WBGene00019838", "Q9UA63", "WBGene00021021", "P34384", "WBGene00008514", "Q9BPN6", "WBGene00022373", "O02220", "WBGene00007712", "Q95QL2", "WBGene00008769", "A0A1N7SYX2", "WBGene00003066", "O18180", "WBGene00012361", "P90993", "WBGene00015185", "P34264", "WBGene00015133", "Q9TZ90", "WBGene00018793", "Q21083", "WBGene00010458", "O17005", "WBGene00020717", "Q7KPW7", "WBGene00017997", "Q4W5T0", "WBGene00044344", "Q22623", "WBGene00011883", "Q9NAG2", "WBGene00012992", "Q21939", "WBGene00011247", "O45110", "WBGene00018932", "O44159", "WBGene00016989", "Q95Y83", "WBGene00022470", "Q2L6V2", "WBGene00015092", "P34378", "WBGene00017044", "C0VXV6", "WBGene00021935", "Q9N3F3", "WBGene00021829", "Q95Y71", "WBGene00022493", "Q22140", "WBGene00011412", "P90915", "WBGene00010616", "P49404", "WBGene00016142", "Q95X39", "WBGene00015025", "O76606", "WBGene00020796", "Q9TYJ8", "WBGene00022045", "P91353", "WBGene00019076", "O17839", "WBGene00009128", "Q9GYS9", "WBGene00020348", "Q7YX52", "WBGene00008459", "Q9XX18", "WBGene00012645", "Q22438", "WBGene00011740", "Q6A575", "WBGene00023422", "Q7YWY8", "WBGene00010783", "O18199", "WBGene00013004" ] }, "reaction_10552327": { "compartment": "compartment_5460", "id": "reaction_10552327", "reactome": "R-CEL-5419273", "name": "Hydrolysis of GTP and dissociation of 28S and 39S subunits", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10552322" ], "products": [ "species_10552270", "species_10552030", "species_113548", "species_10552324", "species_10552320" ], "modifiers": [ [ "species_10552322", "catalyst" ] ], "additional_components": [ "P91478", "WBGene00020625", "Q93425", "WBGene00008452", "Q9U3Q0", "WBGene00007564", "O61791", "WBGene00020037", "P34748", "WBGene00014224", "Q95Q11", "WBGene00013324", "Q688C0", "WBGene00023487", "P34388", "WBGene00017319", "Q9N361", "WBGene00021920", "Q95QS3", "WBGene00016412", "Q9XWV5", "WBGene00012556", "G5ECC9", "WBGene00010766", "Q22470", "WBGene00011759", "Q22483", "WBGene00020499", "Q9XWP0", "WBGene00012830", "G5EC67", "WBGene00013210", "Q23155", "WBGene00012244", "Q9XTY5", "WBGene00011391", "O61818", "WBGene00044321", "O44133", "WBGene00016057", "Q09261", "WBGene00007859", "G5EFC8", "WBGene00000933", "P49391", "WBGene00011334", "Q9NAP9", "WBGene00010624", "Q19685", "WBGene00009013", 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"WBGene00015133", "Q9TZ90", "WBGene00018793", "Q21083", "WBGene00010458", "O17005", "WBGene00020717", "Q7KPW7", "WBGene00017997", "Q4W5T0", "WBGene00044344", "Q22623", "WBGene00011883", "Q9NAG2", "WBGene00012992", "Q21939", "WBGene00011247", "O45110", "WBGene00018932", "O44159", "WBGene00016989", "Q95Y83", "WBGene00022470", "Q2L6V2", "WBGene00015092", "P34378", "WBGene00017044", "C0VXV6", "WBGene00021935", "Q9N3F3", "WBGene00021829", "Q95Y71", "WBGene00022493", "Q22140", "WBGene00011412", "P90915", "WBGene00010616", "P49404", "WBGene00016142", "Q95X39", "WBGene00015025", "O76606", "WBGene00020796", "Q9TYJ8", "WBGene00022045", "P91353", "WBGene00019076", "O17839", "WBGene00009128", "Q9GYS9", "WBGene00020348", "Q7YX52", "WBGene00008459", "Q9XX18", "WBGene00012645", "Q22438", "WBGene00011740", "Q6A575", "WBGene00023422", "Q7YWY8", "WBGene00010783", "O18199", "WBGene00013004", "species_29438", "Q95Y73", "WBGene00022491" ] }, "reaction_10552331": { "compartment": "compartment_5460", "id": "reaction_10552331", "reactome": "R-CEL-5419281", "name": "MRRF binds 55S ribosome:mRNA:tRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10552306", "species_10552320" ], "products": [ "species_10552329" ], "modifiers": [], "additional_components": [ "Q93425", "WBGene00008452", "Q9U3Q0", "WBGene00007564", "O61791", "WBGene00020037", "P34748", "WBGene00014224", "Q95Q11", "WBGene00013324", "Q688C0", "WBGene00023487", "P34388", "WBGene00017319", "Q9N361", "WBGene00021920", "Q95QS3", "WBGene00016412", "Q9XWV5", "WBGene00012556", "G5ECC9", "WBGene00010766", "Q22470", "WBGene00011759", "Q22483", "WBGene00020499", "Q9XWP0", "WBGene00012830", "G5EC67", "WBGene00013210", "Q23155", "WBGene00012244", "Q9XTY5", "WBGene00011391", "O61818", "WBGene00044321", "O44133", "WBGene00016057", "Q09261", "WBGene00007859", "G5EFC8", "WBGene00000933", "P49391", "WBGene00011334", "Q9NAP9", "WBGene00010624", "Q19685", "WBGene00009013", "Q9N584", "WBGene00002804", "Q21601", "WBGene00010905", "Q10129", "WBGene00018961", "O17004", "WBGene00020718", "Q11189", "WBGene00015487", "Q9NEI6", "WBGene00012697", "Q09523", "WBGene00008456", "Q9GYI2", "WBGene00017924", "Q21454", "WBGene00010812", "O02207", "WBGene00007215", "Q04907", "WBGene00016249", "Q95QC2", "WBGene00019838", "Q9UA63", "WBGene00021021", "P34384", "WBGene00008514", "Q9BPN6", "WBGene00022373", "O02220", "WBGene00007712", "Q95QL2", "WBGene00008769", "A0A1N7SYX2", "WBGene00003066", "O18180", "WBGene00012361", "P90993", "WBGene00015185", "P34264", "WBGene00015133", "Q9TZ90", "WBGene00018793", "Q21083", "WBGene00010458", "O17005", "WBGene00020717", "Q7KPW7", "WBGene00017997", "Q4W5T0", "WBGene00044344", "Q22623", "WBGene00011883", "Q9NAG2", "WBGene00012992", "Q21939", "WBGene00011247", "O45110", "WBGene00018932", "O44159", "WBGene00016989", "Q95Y83", "WBGene00022470", "Q2L6V2", "WBGene00015092", "P34378", "WBGene00017044", "C0VXV6", "WBGene00021935", "Q9N3F3", "WBGene00021829", "Q95Y71", "WBGene00022493", "Q22140", "WBGene00011412", "P90915", "WBGene00010616", "P49404", "WBGene00016142", "Q95X39", "WBGene00015025", "O76606", "WBGene00020796", "Q9TYJ8", "WBGene00022045", "P91353", "WBGene00019076", "O17839", "WBGene00009128", "Q9GYS9", "WBGene00020348", "Q7YX52", "WBGene00008459", "Q9XX18", "WBGene00012645", "Q22438", "WBGene00011740", "Q6A575", "WBGene00023422", "Q7YWY8", "WBGene00010783", "O18199", "WBGene00013004", "WBGene00020625", "P91478", "WBGene00020625", "Q93425", "WBGene00008452", "Q9U3Q0", "WBGene00007564", "O61791", "WBGene00020037", "P34748", "WBGene00014224", "Q95Q11", "WBGene00013324", "Q688C0", "WBGene00023487", "P34388", "WBGene00017319", "Q9N361", "WBGene00021920", "Q95QS3", "WBGene00016412", "Q9XWV5", "WBGene00012556", "G5ECC9", "WBGene00010766", "Q22470", "WBGene00011759", "Q22483", "WBGene00020499", "Q9XWP0", "WBGene00012830", "G5EC67", "WBGene00013210", "Q23155", "WBGene00012244", "Q9XTY5", "WBGene00011391", "O61818", "WBGene00044321", "O44133", "WBGene00016057", "Q09261", "WBGene00007859", "G5EFC8", "WBGene00000933", "P49391", "WBGene00011334", "Q9NAP9", "WBGene00010624", "Q19685", "WBGene00009013", "Q9N584", "WBGene00002804", "Q21601", "WBGene00010905", "Q10129", "WBGene00018961", "O17004", "WBGene00020718", "Q11189", "WBGene00015487", "Q9NEI6", "WBGene00012697", "Q09523", "WBGene00008456", "Q9GYI2", "WBGene00017924", "Q21454", "WBGene00010812", "O02207", "WBGene00007215", "Q04907", "WBGene00016249", "Q95QC2", "WBGene00019838", "Q9UA63", "WBGene00021021", "P34384", "WBGene00008514", "Q9BPN6", "WBGene00022373", "O02220", "WBGene00007712", "Q95QL2", "WBGene00008769", "A0A1N7SYX2", "WBGene00003066", "O18180", "WBGene00012361", "P90993", "WBGene00015185", "P34264", "WBGene00015133", "Q9TZ90", "WBGene00018793", "Q21083", "WBGene00010458", "O17005", "WBGene00020717", "Q7KPW7", "WBGene00017997", "Q4W5T0", "WBGene00044344", "Q22623", "WBGene00011883", "Q9NAG2", "WBGene00012992", "Q21939", "WBGene00011247", "O45110", "WBGene00018932", "O44159", "WBGene00016989", "Q95Y83", "WBGene00022470", "Q2L6V2", "WBGene00015092", "P34378", "WBGene00017044", "C0VXV6", "WBGene00021935", "Q9N3F3", "WBGene00021829", "Q95Y71", "WBGene00022493", "Q22140", "WBGene00011412", "P90915", "WBGene00010616", "P49404", "WBGene00016142", "Q95X39", "WBGene00015025", "O76606", "WBGene00020796", "Q9TYJ8", "WBGene00022045", "P91353", "WBGene00019076", "O17839", "WBGene00009128", "Q9GYS9", "WBGene00020348", "Q7YX52", "WBGene00008459", "Q9XX18", "WBGene00012645", "Q22438", "WBGene00011740", "Q6A575", "WBGene00023422", "Q7YWY8", "WBGene00010783", "O18199", "WBGene00013004" ] }, "reaction_10552302": { "compartment": "compartment_5460", "id": "reaction_10552302", "reactome": "R-CEL-5419264", "name": "MTRF1L (MTRF1a) or ICT1 binds stop codon in 55S ribosome:mRNA:peptidyl-tRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10552298", "species_113573", "species_10552289" ], "products": [ "species_10552300" ], "modifiers": [], "additional_components": [ "O44568", "WBGene00020993", "Q95QC2", "WBGene00019838", "Q93425", "WBGene00008452", "Q9U3Q0", "WBGene00007564", "O61791", "WBGene00020037", "P34748", "WBGene00014224", "Q95Q11", "WBGene00013324", "Q688C0", "WBGene00023487", "P34388", "WBGene00017319", "Q9N361", "WBGene00021920", "Q95QS3", "WBGene00016412", "Q9XWV5", "WBGene00012556", "G5ECC9", "WBGene00010766", "Q22470", "WBGene00011759", "Q22483", "WBGene00020499", "Q9XWP0", "WBGene00012830", "G5EC67", "WBGene00013210", "Q23155", "WBGene00012244", "Q9XTY5", "WBGene00011391", "O61818", "WBGene00044321", "O44133", "WBGene00016057", "Q09261", "WBGene00007859", "G5EFC8", "WBGene00000933", "P49391", "WBGene00011334", "Q9NAP9", "WBGene00010624", "Q19685", "WBGene00009013", "Q9N584", "WBGene00002804", "Q21601", "WBGene00010905", "Q10129", "WBGene00018961", "O17004", "WBGene00020718", "Q11189", "WBGene00015487", "Q9NEI6", "WBGene00012697", "Q09523", "WBGene00008456", "Q9GYI2", "WBGene00017924", "Q21454", "WBGene00010812", "O02207", "WBGene00007215", "Q04907", "WBGene00016249", "Q95QC2", "WBGene00019838", "Q9UA63", "WBGene00021021", "P34384", "WBGene00008514", "Q9BPN6", "WBGene00022373", "O02220", "WBGene00007712", "Q95QL2", "WBGene00008769", "A0A1N7SYX2", "WBGene00003066", "O18180", "WBGene00012361", "P90993", "WBGene00015185", "P34264", "WBGene00015133", "Q9TZ90", "WBGene00018793", "Q21083", "WBGene00010458", "O17005", "WBGene00020717", "Q7KPW7", "WBGene00017997", "Q4W5T0", "WBGene00044344", "Q22623", "WBGene00011883", "Q9NAG2", "WBGene00012992", "Q21939", "WBGene00011247", "O45110", "WBGene00018932", "O44159", "WBGene00016989", "Q95Y83", "WBGene00022470", "Q2L6V2", "WBGene00015092", "P34378", "WBGene00017044", "C0VXV6", "WBGene00021935", "Q9N3F3", "WBGene00021829", "Q95Y71", "WBGene00022493", "Q22140", "WBGene00011412", "P90915", "WBGene00010616", "P49404", "WBGene00016142", "Q95X39", "WBGene00015025", "O76606", "WBGene00020796", "Q9TYJ8", "WBGene00022045", "P91353", "WBGene00019076", "O17839", "WBGene00009128", "Q9GYS9", "WBGene00020348", "Q7YX52", "WBGene00008459", "Q9XX18", "WBGene00012645", "Q22438", "WBGene00011740", "Q6A575", "WBGene00023422", "Q7YWY8", "WBGene00010783", "O18199", "WBGene00013004", "Q93425", "WBGene00008452", "Q9U3Q0", "WBGene00007564", "O61791", "WBGene00020037", "P34748", "WBGene00014224", "Q95Q11", "WBGene00013324", "Q688C0", "WBGene00023487", "P34388", "WBGene00017319", "Q9N361", "WBGene00021920", "Q95QS3", "WBGene00016412", "Q9XWV5", "WBGene00012556", "G5ECC9", "WBGene00010766", "Q22470", "WBGene00011759", "Q22483", "WBGene00020499", "Q9XWP0", "WBGene00012830", "G5EC67", "WBGene00013210", "Q23155", "WBGene00012244", "Q9XTY5", "WBGene00011391", "O61818", "WBGene00044321", "O44133", "WBGene00016057", "Q09261", "WBGene00007859", "G5EFC8", "WBGene00000933", "P49391", "WBGene00011334", "Q9NAP9", "WBGene00010624", "Q19685", "WBGene00009013", "Q9N584", "WBGene00002804", "Q21601", "WBGene00010905", "Q10129", "WBGene00018961", "O17004", "WBGene00020718", "Q11189", "WBGene00015487", "Q9NEI6", "WBGene00012697", "Q09523", "WBGene00008456", "Q9GYI2", "WBGene00017924", "Q21454", "WBGene00010812", "O02207", "WBGene00007215", "Q04907", "WBGene00016249", "Q95QC2", "WBGene00019838", "Q9UA63", "WBGene00021021", "P34384", "WBGene00008514", "Q9BPN6", "WBGene00022373", "O02220", "WBGene00007712", "Q95QL2", "WBGene00008769", "A0A1N7SYX2", "WBGene00003066", "O18180", "WBGene00012361", "P90993", "WBGene00015185", "P34264", "WBGene00015133", "Q9TZ90", "WBGene00018793", "Q21083", "WBGene00010458", "O17005", "WBGene00020717", "Q7KPW7", "WBGene00017997", "Q4W5T0", "WBGene00044344", "Q22623", "WBGene00011883", "Q9NAG2", "WBGene00012992", "Q21939", "WBGene00011247", "O45110", "WBGene00018932", "O44159", "WBGene00016989", "Q95Y83", "WBGene00022470", "Q2L6V2", "WBGene00015092", "P34378", "WBGene00017044", "C0VXV6", "WBGene00021935", "Q9N3F3", "WBGene00021829", "Q95Y71", "WBGene00022493", "Q22140", "WBGene00011412", "P90915", "WBGene00010616", "P49404", "WBGene00016142", "Q95X39", "WBGene00015025", "O76606", "WBGene00020796", "Q9TYJ8", "WBGene00022045", "P91353", "WBGene00019076", "O17839", "WBGene00009128", "Q9GYS9", "WBGene00020348", "Q7YX52", "WBGene00008459", "Q9XX18", "WBGene00012645", "Q22438", "WBGene00011740", "Q6A575", "WBGene00023422", "Q7YWY8", "WBGene00010783", "O18199", "WBGene00013004", "species_29438", "O44568", "WBGene00020993" ] }, "reaction_10535860": { "compartment": "compartment_984", "id": "reaction_10535860", "reactome": "R-CEL-1602374", "name": "PS is hydrolyzed to 1-acyl LPS by PLA2[15]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_33625" ], "products": [ "species_1602419", "species_1602366" ], "modifiers": [ [ "species_10535837", "catalyst" ], [ "species_10535855", "inhibitor" ] ], "additional_components": [ "species_74016", "Q17790", "WBGene00044468", "O16654", "WBGene00044468", "Q3V5J7", "WBGene00044468", "Q18339", "WBGene00016288", "G4RY15", "WBGene00015631", "P34472", "WBGene00010228", "Q22591", "WBGene00020585" ] }, "reaction_10534870": { "compartment": "compartment_12045", "id": "reaction_10534870", "reactome": "R-CEL-1482776", "name": "PS is hydrolyzed to 1-acyl LPS by PLA2G2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1500646" ], "products": [ "species_1524021", "species_1498724" ], "modifiers": [ [ "species_10534852", "catalyst" ] ], "additional_components": [ "Q3V5J7", "WBGene00044468", "O16654", "WBGene00044468", "Q17790", "WBGene00044468", "species_74016" ] }, "reaction_10534806": { "compartment": "compartment_12045", "id": "reaction_10534806", "reactome": "R-CEL-1482636", "name": "1-acyl LPS is acylated to PS by LPSAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500578", "species_1498724" ], "products": [ "species_76194", "species_1500646" ], "modifiers": [ [ "species_10534803", "catalyst" ] ], "additional_components": [ "G5EC53", "WBGene00016934", "H9G2W5", "WBGene00007446", "O01925", "WBGene00020115" ] }, "reaction_10566472": { "compartment": "compartment_12045", "id": "reaction_10566472", "reactome": "R-CEL-8867876", "name": "OSBPL5,8,10 exchange PS with PI4P from ER membrane to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_392417", "species_1500646" ], "products": [ "species_33625", "species_1806234" ], "modifiers": [ [ "species_10566469", "catalyst" ] ], "additional_components": [ "WBGene00014215" ] }, "reaction_10534861": { "compartment": "compartment_12045", "id": "reaction_10534861", "reactome": "R-CEL-1482691", "name": "2-acyl LPS is acylated to PS by LPSAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500578", "species_1498722" ], "products": [ "species_76194", "species_1500646" ], "modifiers": [ [ "species_10534803", "catalyst" ] ], "additional_components": [ "G5EC53", "WBGene00016934", "H9G2W5", "WBGene00007446", "O01925", "WBGene00020115" ] }, "reaction_10570607": { "compartment": "compartment_5460", "id": "reaction_10570607", "reactome": "R-CEL-8986181", "name": "PITRM1 proteolyzes mitochondrial targeting peptides (presequences)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10570599" ], "products": [], "modifiers": [ [ "species_10570604", "catalyst" ] ], "additional_components": [ "Q9XWJ5", "WBGene00013094", "WBGene00011679" ] }, "reaction_10529207": { "compartment": "compartment_876", "id": "reaction_10529207", "reactome": "R-CEL-917870", "name": "SLC46A1 transports hemes from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9707310" ], "products": [ "species_9707308" ], "modifiers": [ [ "species_10514650", "catalyst" ] ], "additional_components": [ "species_71185", "Q9UAZ6", "WBGene00021159", "Q9XWL3", "WBGene00012811", "H2KZC0", "WBGene00016705", "Q20236", "WBGene00009582" ] }, "reaction_10532366": { "compartment": "compartment_70101", "id": "reaction_10532366", "reactome": "R-CEL-1247960", "name": "Activation of p38 MAPK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10532355" ], "products": [ "species_10532363", "species_29370" ], "modifiers": [ [ "species_10525519", "catalyst" ] ], "additional_components": [ "WBGene00004758" ] }, "reaction_10532487": { "compartment": "compartment_70101", "id": "reaction_10532487", "reactome": "R-CEL-1250264", "name": "TXNIP binds reduced thioredoxin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10532483", "species_10506160" ], "products": [ "species_10532485" ], "modifiers": [], "additional_components": [ "P91469", "WBGene00020612", "Q9XXN6", "WBGene00009000", "O17982", "WBGene00011054", "Q9GYT5", "WBGene00018060", "Q20577", "WBGene00009852", "O17983", "WBGene00011055", "Q9TYQ0", "WBGene00019873", "Q21550", "WBGene00006429", "O44847", "WBGene00020205", "Q9XTU0", "WBGene00013043", "Q22321", "WBGene00020323", "O45782", "WBGene00011732", "Q9XXC4", "WBGene00013086", "D1MN74", "WBGene00009579", "Q23672", "WBGene00014159", "O62274", "WBGene00010268", "Q9XXI0", "WBGene00012467", "O17812", "WBGene00008843", "Q23674", "WBGene00014161", "P30647", "WBGene00014033", "Q9XXI4", "WBGene00012464", "O17981", "WBGene00011052", "Q9GYT4", "WBGene00018061", "WBGene00015062", "Q09433", "WBGene00015062", "P91469", "WBGene00020612", "Q9XXN6", "WBGene00009000", "O17982", "WBGene00011054", "Q9GYT5", "WBGene00018060", "Q20577", "WBGene00009852", "O17983", "WBGene00011055", "Q9TYQ0", "WBGene00019873", "Q21550", "WBGene00006429", "O44847", "WBGene00020205", "Q9XTU0", "WBGene00013043", "Q22321", "WBGene00020323", "O45782", "WBGene00011732", "Q9XXC4", "WBGene00013086", "D1MN74", "WBGene00009579", "Q23672", "WBGene00014159", "O62274", "WBGene00010268", "Q9XXI0", "WBGene00012467", "O17812", "WBGene00008843", "Q23674", "WBGene00014161", "P30647", "WBGene00014033", "Q9XXI4", "WBGene00012464", "O17981", "WBGene00011052", "Q9GYT4", "WBGene00018061" ] }, "reaction_10532489": { "compartment": "compartment_70101", "id": "reaction_10532489", "reactome": "R-CEL-1250280", "name": "ROS oxidize thioredoxin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10506160", "species_1250243" ], "products": [ "species_10506158" ], "modifiers": [], "additional_components": [ "WBGene00015062", "WBGene00015062" ] }, "reaction_10571508": { "compartment": "compartment_7660", "id": "reaction_10571508", "reactome": "R-CEL-9021357", "name": "PRKCI phosphorylates ELF3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10571503" ], "products": [ "species_113582", "species_10571503" ], "modifiers": [ [ "species_10571505", "catalyst" ] ], "additional_components": [ "WBGene00006462", "WBGene00006462", "WBGene00004034" ] }, "reaction_10538172": { "compartment": "compartment_70101", "id": "reaction_10538172", "reactome": "R-CEL-1912382", "name": "Mature NOTCH heterodimer traffics to the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10538156" ], "products": [ "species_10538165" ], "modifiers": [ [ "species_10538170", "inhibitor" ] ], "additional_components": [ "Q21850", "WBGene00019957", "Q21850", "WBGene00019957", "WBGene00004766" ] }, "reaction_10532496": { "compartment": "compartment_876", "id": "reaction_10532496", "reactome": "R-CEL-1250370", "name": "Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10532493", "catalyst" ] ], "additional_components": [ "G5EDP9", "WBGene00000001", "Q94125", "WBGene00000090" ] }, "reaction_10532624": { "compartment": "compartment_70101", "id": "reaction_10532624", "reactome": "R-CEL-1253343", "name": "WWOX binds ERBB4s80", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10532620", "species_10532532" ], "products": [ "species_10532622" ], "modifiers": [], "additional_components": [ "WBGene00000971", "P24348", "WBGene00002299", "P24348", "WBGene00002299", "Q19062", "WBGene00000971" ] }, "reaction_10532677": { "compartment": "compartment_70101", "id": "reaction_10532677", "reactome": "R-CEL-1254376", "name": "Translocation of cytosolic ERBB4s80 to mitochondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10532532" ], "products": [ "species_10532675" ], "modifiers": [], "additional_components": [ "P24348", "WBGene00002299", "P24348", "WBGene00002299" ] }, "reaction_10532663": { "compartment": "compartment_70101", "id": "reaction_10532663", "reactome": "R-CEL-1254285", "name": "ERBB4s80:STAT5A complex translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10532651" ], "products": [ "species_10532661" ], "modifiers": [], "additional_components": [ "P24348", "WBGene00002299", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "P24348", "WBGene00002299" ] }, "reaction_10532665": { "compartment": "compartment_70101", "id": "reaction_10532665", "reactome": "R-CEL-1254291", "name": "ERBB4s80 binds STAT5A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10532649", "species_10532532" ], "products": [ "species_10532651" ], "modifiers": [], "additional_components": [ "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "P24348", "WBGene00002299", "P24348", "WBGene00002299", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111" ] }, "reaction_10532603": { "compartment": "compartment_70101", "id": "reaction_10532603", "reactome": "R-CEL-1252013", "name": "Translocation of ERBB4s80 to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10532532" ], "products": [ "species_10532599" ], "modifiers": [ [ "species_10532601", "inhibitor" ] ], "additional_components": [ "P24348", "WBGene00002299", "P24348", "WBGene00002299", "P24348", "WBGene00002299", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635" ] }, "reaction_10532589": { "compartment": "compartment_70101", "id": "reaction_10532589", "reactome": "R-CEL-1251997", "name": "Cleavage of ERBB4m80 by gamma-scretase complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10532522" ], "products": [ "species_10532532" ], "modifiers": [ [ "species_10532586", "catalyst" ] ], "additional_components": [ "P24348", "WBGene00002299", "P24348", "WBGene00002299", "Q23316", "WBGene00000148", "P52166", "WBGene00004769", "Q01608", "WBGene00004958", "O02100", "WBGene00001985", "Q9U357", "WBGene00003975", "O45876", "WBGene00000147" ] }, "reaction_10532637": { "compartment": "compartment_70101", "id": "reaction_10532637", "reactome": "R-CEL-1254248", "name": "Translocation of ERBB4s80:YAP1 complex to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10532631" ], "products": [ "species_10532635" ], "modifiers": [], "additional_components": [ "P24348", "WBGene00002299", "Q19404", "WBGene00008748", "P24348", "WBGene00002299", "Q19404", "WBGene00008748" ] }, "reaction_10532639": { "compartment": "compartment_70101", "id": "reaction_10532639", "reactome": "R-CEL-1254251", "name": "ERBB4s80 binds YAP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10532629", "species_10532532" ], "products": [ "species_10532631" ], "modifiers": [], "additional_components": [ "WBGene00008748", "P24348", "WBGene00002299", "P24348", "WBGene00002299", "Q19404", "WBGene00008748" ] }, "reaction_10538338": { "compartment": "compartment_70101", "id": "reaction_10538338", "reactome": "R-CEL-1977296", "name": "NEDD4 ubiquitinates ERBB4jmAcyt1s80 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10538331", "species_10502375" ], "products": [ "species_10538335" ], "modifiers": [ [ "species_10538331", "catalyst" ] ], "additional_components": [ "A0A061ACQ8", "WBGene00022358", "P24348", "WBGene00002299", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "A0A061ACQ8", "WBGene00022358", "P24348", "WBGene00002299", "A0A061ACQ8", "WBGene00022358", "P24348", "WBGene00002299" ] }, "reaction_10532613": { "compartment": "compartment_70101", "id": "reaction_10532613", "reactome": "R-CEL-1253282", "name": "ERBB4 ubiquitination by WWP1/ITCH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502375", "species_10532608" ], "products": [ "species_10532610" ], "modifiers": [ [ "species_10532608", "catalyst" ] ], "additional_components": [ "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "Q9N2Z7", "WBGene00007009", "P24348", "WBGene00002299", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "Q9N2Z7", "WBGene00007009", "P24348", "WBGene00002299", "Q9N2Z7", "WBGene00007009", "P24348", "WBGene00002299" ] }, "reaction_10532615": { "compartment": "compartment_876", "id": "reaction_10532615", "reactome": "R-CEL-1253300", "name": "ERBB4 binds WWP1/ITCH ubiquitin ligases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10532606", "species_10530908" ], "products": [ "species_10532608" ], "modifiers": [], "additional_components": [ "P24348", "WBGene00002299", "WBGene00007009", "Q9N2Z7", "WBGene00007009", "P24348", "WBGene00002299" ] }, "reaction_10572102": { "compartment": "compartment_876", "id": "reaction_10572102", "reactome": "R-CEL-9612219", "name": "ERBB4s80 binds to SRC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10518187", "species_10532532" ], "products": [ "species_10532601" ], "modifiers": [], "additional_components": [ "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "P24348", "WBGene00002299", "P24348", "WBGene00002299", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635" ] }, "reaction_10538333": { "compartment": "compartment_70101", "id": "reaction_10538333", "reactome": "R-CEL-1973956", "name": "NEDD4 binds ERBB4jmAcyt1s80 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10532526", "species_10530876" ], "products": [ "species_10538331" ], "modifiers": [], "additional_components": [ "P24348", "WBGene00002299", "WBGene00022358", "A0A061ACQ8", "WBGene00022358", "P24348", "WBGene00002299" ] }, "reaction_10509830": { "compartment": "compartment_70101", "id": "reaction_10509830", "reactome": "R-CEL-141429", "name": "Inactivation of APC/C via CDC20 sequestration", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509819", "species_10509824" ], "products": [ "species_10509828" ], "modifiers": [], "additional_components": [ "WBGene00001511", "WBGene00003161", "Q9NGT3", "WBGene00003161", "Q09373", "WBGene00001511" ] }, "reaction_10509832": { "compartment": "compartment_70101", "id": "reaction_10509832", "reactome": "R-CEL-141437", "name": "Formation of the MCC complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509819", "species_10509814", "species_10509809", "species_10509824" ], "products": [ "species_10509826" ], "modifiers": [], "additional_components": [ "WBGene00001511", "WBGene00013209", "WBGene00000275", "WBGene00003161", "Q9NGT3", "WBGene00003161", "Q21776", "WBGene00000275", "Q9XWH0", "WBGene00013209", "Q09373", "WBGene00001511" ] }, "reaction_10511637": { "compartment": "compartment_7660", "id": "reaction_10511637", "reactome": "R-CEL-174251", "name": "Phosphorylation of Cdh1 by Cyclin B1:Cdc2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10511632" ], "products": [ "species_113582", "species_10511634" ], "modifiers": [ [ "species_10511241", "catalyst" ] ], "additional_components": [ "WBGene00001510", "WBGene00001510", "O45926", "WBGene00000866", "Q10653", "WBGene00000865", "Q9BLB5", "WBGene00000867", "P34556", "WBGene00000405" ] }, "reaction_10522739": { "compartment": "compartment_70101", "id": "reaction_10522739", "reactome": "R-CEL-426240", "name": "DAG kinase produces phosphatidic acid from DAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_114519" ], "products": [ "species_76108", "species_29370" ], "modifiers": [ [ "species_10522736", "catalyst" ] ], "additional_components": [ "Q03603", "WBGene00000960", "Q10024", "WBGene00019428", "H2KZC9", "WBGene00006483", "H2KYI9", "WBGene00000959", "Q17860", "WBGene00000958" ] }, "reaction_10509684": { "compartment": "compartment_114521", "id": "reaction_10509684", "reactome": "R-CEL-139854", "name": "IP3R tetramer:I(1,4,5)P3:4xCa2+ transports Ca2+ from platelet dense tubular system to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_139827" ], "products": [ "species_74016" ], "modifiers": [ [ "species_10509681", "catalyst" ] ], "additional_components": [ "species_114520", "species_74016", "Q9Y0A1", "WBGene00002173" ] }, "reaction_10522615": { "compartment": "compartment_876", "id": "reaction_10522615", "reactome": "R-CEL-426032", "name": "DAG is metabolized by DAGL to 2-AG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_114519" ], "products": [ "species_426026", "species_426030" ], "modifiers": [ [ "species_10522612", "catalyst" ] ], "additional_components": [ "WBGene00018364" ] }, "reaction_10557468": { "compartment": "compartment_876", "id": "reaction_10557468", "reactome": "R-CEL-5694462", "name": "ABHD6,12 hydrolyse 3AG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_5694509" ], "products": [ "species_422506", "species_70106", "species_76116" ], "modifiers": [ [ "species_10557465", "catalyst" ] ], "additional_components": [ "WBGene00022393" ] }, "reaction_10509686": { "compartment": "compartment_70101", "id": "reaction_10509686", "reactome": "R-CEL-139941", "name": "Binding of IP3 to IP3 receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509679", "species_114520" ], "products": [ "species_10509681" ], "modifiers": [], "additional_components": [ "Q9Y0A1", "WBGene00002173", "species_114520", "species_74016", "Q9Y0A1", "WBGene00002173" ] }, "reaction_10522696": { "compartment": "compartment_876", "id": "reaction_10522696", "reactome": "R-CEL-426209", "name": "DAG activation of TRPC channels", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_114519", "species_10522688" ], "products": [ "species_10522694" ], "modifiers": [], "additional_components": [ "WBGene00006615", "Q8I6Y9", "WBGene00006615", "species_114519" ] }, "reaction_10522510": { "compartment": "compartment_70101", "id": "reaction_10522510", "reactome": "R-CEL-425861", "name": "Activation of Protein Kinase C novel isoforms", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_114519", "species_10513858" ], "products": [ "species_10522508" ], "modifiers": [], "additional_components": [ "P34885", "WBGene00004032", "P34722", "WBGene00006599", "P34885", "WBGene00004032", "P34722", "WBGene00006599", "species_114519" ] }, "reaction_10506679": { "compartment": "compartment_70101", "id": "reaction_10506679", "reactome": "R-CEL-74372", "name": "uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_83962", "species_500244" ], "products": [ "species_29372", "species_500430" ], "modifiers": [ [ "species_10506676", "catalyst" ] ], "additional_components": [ "CHEBI:28542", "species_112016", "CHEBI:16450", "CHEBI:16704", "Q23588", "WBGene00022817" ] }, "reaction_10508615": { "compartment": "compartment_70101", "id": "reaction_10508615", "reactome": "R-CEL-109903", "name": "cytidine or uridine + ATP => CMP or UMP + ADP [UCK2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_500759" ], "products": [ "species_500761", "species_29370" ], "modifiers": [ [ "species_10508612", "catalyst" ] ], "additional_components": [ "CHEBI:16704", "CHEBI:17562", "species_109395", "species_109402", "Q17413", "WBGene00007089" ] }, "reaction_10558281": { "compartment": "compartment_70101", "id": "reaction_10558281", "reactome": "R-CEL-6788295", "name": "HDHD1:Mg2+ dephosphorylates PURIDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_6788291" ], "products": [ "species_29372", "species_6788290" ], "modifiers": [ [ "species_10558278", "catalyst" ] ], "additional_components": [ "G5EG26", "WBGene00020113", "species_114632" ] }, "reaction_10506106": { "compartment": "compartment_70101", "id": "reaction_10506106", "reactome": "R-CEL-73599", "name": "cytidine or uridine + ATP => CMP or UMP + ADP [UCK1]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_500759" ], "products": [ "species_500761", "species_29370" ], "modifiers": [ [ "species_10506103", "catalyst" ] ], "additional_components": [ "CHEBI:16704", "CHEBI:17562", "species_109395", "species_109402", "Q17413", "WBGene00007089" ] }, "reaction_10569948": { "compartment": "compartment_70101", "id": "reaction_10569948", "reactome": "R-CEL-8954327", "name": "UCKL1 phosphorylates urindine, cytidine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_500759" ], "products": [ "species_500761", "species_29370" ], "modifiers": [ [ "species_10569945", "catalyst" ] ], "additional_components": [ "CHEBI:16704", "CHEBI:17562", "species_109395", "species_109402", "WBGene00008948" ] }, "reaction_10506142": { "compartment": "compartment_70101", "id": "reaction_10506142", "reactome": "R-CEL-73632", "name": "thymidine + ATP => TMP (deoxythymidine 5'-monophosphate) + ADP [TK1]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_83928" ], "products": [ "species_29370", "species_109366" ], "modifiers": [ [ "species_10506139", "catalyst" ] ], "additional_components": [ "G5EEZ5", "WBGene00006568" ] }, "reaction_10506126": { "compartment": "compartment_70101", "id": "reaction_10506126", "reactome": "R-CEL-73608", "name": "(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_500829" ], "products": [ "species_500430", "species_31633" ], "modifiers": [ [ "species_10506123", "catalyst" ] ], "additional_components": [ "CHEBI:15698", "CHEBI:17562", "CHEBI:16450", "CHEBI:16704", "species_216785", "Q20628", "WBGene00000392" ] }, "reaction_10509057": { "compartment": "compartment_70101", "id": "reaction_10509057", "reactome": "R-CEL-111966", "name": "GRK2 binds CALM1:4Ca2+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509037", "species_10508995" ], "products": [ "species_10509039" ], "modifiers": [ [ "species_10509055", "inhibitor" ] ], "additional_components": [ "WBGene00001709", "species_74016", "Q11083", "WBGene00020378", "P04630", "WBGene00000285", "G5EF37", "WBGene00003934", "A0A2C9C3L3", "WBGene00020378", "Q18136", "WBGene00006861", "Q09665", "WBGene00006583", "O02159", "WBGene00020378", "G5EDZ8", "WBGene00000288", "Q94288", "WBGene00000287", "Q09980", "WBGene00017394", "O16305", "WBGene00000552", "G5EEG0", "WBGene00000286", "species_74016", "Q11083", "WBGene00020378", "P04630", "WBGene00000285", "G5EF37", "WBGene00003934", "A0A2C9C3L3", "WBGene00020378", "Q18136", "WBGene00006861", "Q09665", "WBGene00006583", "O02159", "WBGene00020378", "G5EDZ8", "WBGene00000288", "Q94288", "WBGene00000287", "Q09980", "WBGene00017394", "O16305", "WBGene00000552", "G5EEG0", "WBGene00000286", "Q09639", "WBGene00001709", "species_74016", "P90980", "WBGene00004033", "P34722", "WBGene00006599" ] }, "reaction_10508962": { "compartment": "compartment_70101", "id": "reaction_10508962", "reactome": "R-CEL-111925", "name": "cAMP induces dissociation of inactive PKA tetramers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508958" ], "products": [ "species_10508954", "species_10508960" ], "modifiers": [], "additional_components": [ "species_30389", "P30625", "WBGene00002190", "P21137", "WBGene00002189", "WBGene00002189", "P30625", "WBGene00002190", "species_30389" ] }, "reaction_10508997": { "compartment": "compartment_876", "id": "reaction_10508997", "reactome": "R-CEL-111930", "name": "Adenylate cyclase produces cAMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592" ], "products": [ "species_111294", "species_30389" ], "modifiers": [ [ "species_10508992", "catalyst" ], [ "species_10508995", "catalyst" ] ], "additional_components": [ "species_114632", "Q19523", "WBGene00000068", "O16880", "WBGene00000069", "G5EE33", "WBGene00000070", "Q966F9", "WBGene00000071", "species_74016", "Q11083", "WBGene00020378", "P04630", "WBGene00000285", "G5EF37", "WBGene00003934", "A0A2C9C3L3", "WBGene00020378", "Q18136", "WBGene00006861", "Q09665", "WBGene00006583", "O02159", "WBGene00020378", "G5EDZ8", "WBGene00000288", "Q94288", "WBGene00000287", "Q09980", "WBGene00017394", "O16305", "WBGene00000552", "G5EEG0", "WBGene00000286" ] }, "reaction_10569054": { "compartment": "compartment_70101", "id": "reaction_10569054", "reactome": "R-CEL-8951727", "name": "cAMP binds PKA tetramer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508956", "species_30389" ], "products": [ "species_10508958" ], "modifiers": [], "additional_components": [ "P30625", "WBGene00002190", "P21137", "WBGene00002189", "species_30389", "P30625", "WBGene00002190", "P21137", "WBGene00002189" ] }, "reaction_10509064": { "compartment": "compartment_876", "id": "reaction_10509064", "reactome": "R-CEL-111970", "name": "PKC phosphorylates GRK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509037", "species_113592" ], "products": [ "species_29370", "species_10509061" ], "modifiers": [ [ "species_10509055", "catalyst" ] ], "additional_components": [ "WBGene00001709", "WBGene00001709", "species_74016", "P90980", "WBGene00004033", "P34722", "WBGene00006599" ] }, "reaction_10524537": { "compartment": "compartment_70101", "id": "reaction_10524537", "reactome": "R-CEL-442749", "name": "CaMKK autophosphorylates in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10524529" ], "products": [ "species_113582", "species_10524534" ], "modifiers": [ [ "species_10524529", "catalyst" ] ], "additional_components": [ "species_74016", "A0A2C9C3L3", "WBGene00020378", "Q09980", "WBGene00017394", "G5EDZ8", "WBGene00000288", "Q11083", "WBGene00020378", "G5EEG0", "WBGene00000286", "Q18136", "WBGene00006861", "G5EF37", "WBGene00003934", "Q94288", "WBGene00000287", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "P04630", "WBGene00000285", "Q09665", "WBGene00006583", "Q3Y416", "WBGene00000518", "Q3Y416", "WBGene00000518", "species_74016", "A0A2C9C3L3", "WBGene00020378", "Q09980", "WBGene00017394", "G5EDZ8", "WBGene00000288", "Q11083", "WBGene00020378", "G5EEG0", "WBGene00000286", "Q18136", "WBGene00006861", "G5EF37", "WBGene00003934", "Q94288", "WBGene00000287", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "P04630", "WBGene00000285", "Q09665", "WBGene00006583", "species_74016", "A0A2C9C3L3", "WBGene00020378", "Q09980", "WBGene00017394", "G5EDZ8", "WBGene00000288", "Q11083", "WBGene00020378", "G5EEG0", "WBGene00000286", "Q18136", "WBGene00006861", "G5EF37", "WBGene00003934", "Q94288", "WBGene00000287", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "P04630", "WBGene00000285", "Q09665", "WBGene00006583", "Q3Y416", "WBGene00000518" ] }, "reaction_10509018": { "compartment": "compartment_70101", "id": "reaction_10509018", "reactome": "R-CEL-111955", "name": "cAMP hydrolysis by Cam-PDE 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_30389" ], "products": [ "species_76577" ], "modifiers": [ [ "species_10509015", "catalyst" ] ], "additional_components": [ "O18696", "WBGene00011433" ] }, "reaction_10509020": { "compartment": "compartment_70101", "id": "reaction_10509020", "reactome": "R-CEL-111956", "name": "Calmodulin activates Cam-PDE 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509015" ], "products": [ "species_10509015" ], "modifiers": [ [ "species_10508995", "catalyst" ] ], "additional_components": [ "O18696", "WBGene00011433", "O18696", "WBGene00011433", "species_74016", "Q11083", "WBGene00020378", "P04630", "WBGene00000285", "G5EF37", "WBGene00003934", "A0A2C9C3L3", "WBGene00020378", "Q18136", "WBGene00006861", "Q09665", "WBGene00006583", "O02159", "WBGene00020378", "G5EDZ8", "WBGene00000288", "Q94288", "WBGene00000287", "Q09980", "WBGene00017394", "O16305", "WBGene00000552", "G5EEG0", "WBGene00000286" ] }, "reaction_10562897": { "compartment": "compartment_876", "id": "reaction_10562897", "reactome": "R-CEL-6801101", "name": "RABGGTA binds RABGGTB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10562893", "species_10562888" ], "products": [ "species_10562895" ], "modifiers": [], "additional_components": [ "WBGene00015099", "WBGene00019778", "Q9TYY0", "WBGene00019778", "P41992", "WBGene00015099" ] }, "reaction_10562906": { "compartment": "compartment_70101", "id": "reaction_10562906", "reactome": "R-CEL-6801109", "name": "CHM binds RGGT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10562895", "species_10562902" ], "products": [ "species_10562904" ], "modifiers": [], "additional_components": [ "Q9TYY0", "WBGene00019778", "P41992", "WBGene00015099", "WBGene00022051", "Q9BKQ5", "WBGene00022051", "Q9TYY0", "WBGene00019778", "P41992", "WBGene00015099" ] }, "reaction_10562850": { "compartment": "compartment_70101", "id": "reaction_10562850", "reactome": "R-CEL-6800793", "name": "PIDD1 translocates to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10562842" ], "products": [ "species_10562848" ], "modifiers": [], "additional_components": [ "Q09564", "WBGene00009647", "Q17989", "WBGene00015779", "Q09564", "WBGene00009647", "Q17989", "WBGene00015779" ] }, "reaction_10563082": { "compartment": "compartment_7660", "id": "reaction_10563082", "reactome": "R-CEL-6805061", "name": "CK2 binds FACT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10563078", "species_10509283" ], "products": [ "species_10563080" ], "modifiers": [], "additional_components": [ "P18334", "WBGene00002191", "P28548", "WBGene00002196", "Q9N5R9", "WBGene00018849", "P41848", "WBGene00001974", "Q9N5R9", "WBGene00018849", "P41848", "WBGene00001974", "P18334", "WBGene00002191", "P28548", "WBGene00002196" ] }, "reaction_10567715": { "compartment": "compartment_7660", "id": "reaction_10567715", "reactome": "R-CEL-8877692", "name": "PIN1 binds phosphorylated PIP4K2B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10567708", "species_10529334" ], "products": [ "species_10567713" ], "modifiers": [], "additional_components": [ "Q9BL73", "WBGene00004088", "WBGene00022448", "Q9N492", "WBGene00022448", "Q9BL73", "WBGene00004088" ] }, "reaction_10567711": { "compartment": "compartment_7660", "id": "reaction_10567711", "reactome": "R-CEL-8877691", "name": "MAP2K6 phosphorylates PIP4K2B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10567697" ], "products": [ "species_113582", "species_10567708" ], "modifiers": [ [ "species_10525531", "catalyst" ] ], "additional_components": [ "Q9BL73", "WBGene00004088", "Q9BL73", "WBGene00004088", "WBGene00004758" ] }, "reaction_10559206": { "compartment": "compartment_70101", "id": "reaction_10559206", "reactome": "R-CEL-6795290", "name": "TORC2 complex phosphorylates SGK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10545420", "species_113592" ], "products": [ "species_29370", "species_10559204" ], "modifiers": [ [ "species_10513953", "catalyst" ] ], "additional_components": [ "WBGene00004789", "WBGene00004789", "P91040", "WBGene00015697", "Q95Q95", "WBGene00002583", "G5EFN2", "WBGene00009245", "Q9NA80", "WBGene00013261" ] }, "reaction_10559211": { "compartment": "compartment_70101", "id": "reaction_10559211", "reactome": "R-CEL-6795473", "name": "PDPK1 phosphorylates SGK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10559204" ], "products": [ "species_29370", "species_10559209" ], "modifiers": [ [ "species_10508530", "catalyst" ] ], "additional_components": [ "WBGene00004789", "WBGene00004789", "Q9UA62", "WBGene00021022", "species_179838" ] }, "reaction_10559312": { "compartment": "compartment_7660", "id": "reaction_10559312", "reactome": "R-CEL-6797616", "name": "CCNK:CDK12 binds RNA Pol II at DNA repair genes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10559292", "species_10559218" ], "products": [ "species_10559294" ], "modifiers": [], "additional_components": [ "Q9N5R9", "WBGene00018849", "P41848", "WBGene00001974", "Q9N554", "WBGene00021281", "H2KYV0", "WBGene00016115", "P52652", "WBGene00012000", "Q09413", "WBGene00010990", "Q9BKS1", "WBGene00001236", "G5ECR7", "WBGene00001235", "Q9TVL3", "WBGene00000410", "P34424", "WBGene00000508", "P34425", "WBGene00000507", "O17869", "WBGene00009650", "Q9TZ93", "WBGene00005014", "Q21338", "WBGene00005015", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q9XUM4", "WBGene00012236", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "P46551", "WBGene00007135", "O17869", "WBGene00009650", "P46551", "WBGene00007135", "O17869", "WBGene00009650", "Q9N5R9", "WBGene00018849", "P41848", "WBGene00001974", "Q9N554", "WBGene00021281", "H2KYV0", "WBGene00016115", "P52652", "WBGene00012000", "Q09413", "WBGene00010990", "Q9BKS1", "WBGene00001236", "G5ECR7", "WBGene00001235", "Q9TVL3", "WBGene00000410", "P34424", "WBGene00000508", "P34425", "WBGene00000507", "Q9TZ93", "WBGene00005014", "Q21338", "WBGene00005015", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q9XUM4", "WBGene00012236", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529" ] }, "reaction_10559220": { "compartment": "compartment_7660", "id": "reaction_10559220", "reactome": "R-CEL-6797090", "name": "CCNK binds CDK12", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509199", "species_10559216" ], "products": [ "species_10559218" ], "modifiers": [], "additional_components": [ "WBGene00009650", "WBGene00007135", "P46551", "WBGene00007135", "O17869", "WBGene00009650" ] }, "reaction_10559226": { "compartment": "compartment_7660", "id": "reaction_10559226", "reactome": "R-CEL-6797100", "name": "CCNK binds CDK13", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509199", "species_10559222" ], "products": [ "species_10559224" ], "modifiers": [], "additional_components": [ "WBGene00009650", "WBGene00007135", "P46551", "WBGene00007135", "O17869", "WBGene00009650" ] }, "reaction_10559310": { "compartment": "compartment_7660", "id": "reaction_10559310", "reactome": "R-CEL-6797606", "name": "CDK12 phosphorylates RNA Pol II CTD at DNA repair genes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10559294", "species_29358" ], "products": [ "species_113582", "species_10559307" ], "modifiers": [ [ "species_10559294", "catalyst" ] ], "additional_components": [ "P46551", "WBGene00007135", "O17869", "WBGene00009650", "Q9N5R9", "WBGene00018849", "P41848", "WBGene00001974", "Q9N554", "WBGene00021281", "H2KYV0", "WBGene00016115", "P52652", "WBGene00012000", "Q09413", "WBGene00010990", "Q9BKS1", "WBGene00001236", "G5ECR7", "WBGene00001235", "Q9TVL3", "WBGene00000410", "P34424", "WBGene00000508", "P34425", "WBGene00000507", "Q9TZ93", "WBGene00005014", "Q21338", "WBGene00005015", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q9XUM4", "WBGene00012236", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "P46551", "WBGene00007135", "O17869", "WBGene00009650", "Q9N5R9", "WBGene00018849", "P41848", "WBGene00001974", "Q9TVL3", "WBGene00000410", "P34424", "WBGene00000508", "P34425", "WBGene00000507", "Q9TZ93", "WBGene00005014", "Q21338", "WBGene00005015", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q9XUM4", "WBGene00012236", "Q9N554", "WBGene00021281", "H2KYV0", "WBGene00016115", "P52652", "WBGene00012000", "Q09413", "WBGene00010990", "Q9BKS1", "WBGene00001236", "G5ECR7", "WBGene00001235", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "P46551", "WBGene00007135", "O17869", "WBGene00009650", "Q9N5R9", "WBGene00018849", "P41848", "WBGene00001974", "Q9N554", "WBGene00021281", "H2KYV0", "WBGene00016115", "P52652", "WBGene00012000", "Q09413", "WBGene00010990", "Q9BKS1", "WBGene00001236", "G5ECR7", "WBGene00001235", "Q9TVL3", "WBGene00000410", "P34424", "WBGene00000508", "P34425", "WBGene00000507", "Q9TZ93", "WBGene00005014", "Q21338", "WBGene00005015", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q9XUM4", "WBGene00012236", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529" ] }, "reaction_10547457": { "compartment": "compartment_70101", "id": "reaction_10547457", "reactome": "R-CEL-3341343", "name": "PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10506160", "species_29408" ], "products": [ "species_10506158", "species_29356" ], "modifiers": [ [ "species_10547454", "catalyst" ] ], "additional_components": [ "WBGene00015062", "WBGene00015062", "A0A0K3AUJ9", "F09E5.15c" ] }, "reaction_10503060": { "compartment": "compartment_70101", "id": "reaction_10503060", "reactome": "R-CEL-70475", "name": "D-fructose 6-phosphate <=> alpha-D-Glucose 6-phosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29512" ], "products": [ "species_30537" ], "modifiers": [ [ "species_10503055", "catalyst" ] ], "additional_components": [ "Q7K707", "WBGene00013597" ] }, "reaction_10504231": { "compartment": "compartment_70101", "id": "reaction_10504231", "reactome": "R-CEL-71682", "name": "glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_111745" ], "products": [ "species_29450", "species_29366" ], "modifiers": [ [ "species_10504228", "catalyst" ] ], "additional_components": [ "Q93379", "WBGene00008117", "species_113596" ] }, "reaction_10502920": { "compartment": "compartment_70101", "id": "reaction_10502920", "reactome": "R-CEL-70377", "name": "alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30537", "species_29366" ], "products": [ "species_70106", "species_31467", "species_29364" ], "modifiers": [ [ "species_10502917", "catalyst" ] ], "additional_components": [ "species_29366", "Q27464", "WBGene00007108" ] }, "reaction_10506170": { "compartment": "compartment_70101", "id": "reaction_10506170", "reactome": "R-CEL-73646", "name": "thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10506158", "species_70106", "species_29364" ], "products": [ "species_29366", "species_10506160" ], "modifiers": [ [ "species_10506167", "catalyst" ] ], "additional_components": [ "WBGene00015062", "WBGene00015062", "Q17745", "WBGene00015553", "species_113596" ] }, "reaction_10553994": { "compartment": "compartment_70101", "id": "reaction_10553994", "reactome": "R-CEL-5631903", "name": "SESN1,2,3 bind overoxidized PRDX1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10553978", "species_10553986" ], "products": [ "species_10553992" ], "modifiers": [], "additional_components": [ "A0A0K3AUJ9", "F09E5.15c", "WBGene00022279", "Q9N4D6", "WBGene00022279", "A0A0K3AUJ9", "F09E5.15c" ] }, "reaction_10553981": { "compartment": "compartment_70101", "id": "reaction_10553981", "reactome": "R-CEL-5631885", "name": "PRDX1 overoxidizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10547448", "species_29408" ], "products": [ "species_29356", "species_10553978" ], "modifiers": [ [ "species_10547448", "catalyst" ] ], "additional_components": [ "A0A0K3AUJ9", "F09E5.15c", "A0A0K3AUJ9", "F09E5.15c", "A0A0K3AUJ9", "F09E5.15c" ] }, "reaction_10519966": { "compartment": "compartment_70101", "id": "reaction_10519966", "reactome": "R-CEL-380979", "name": "RHEB in mTORC1:RHEB:GTP hydrolyses GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10510588" ], "products": [ "species_29372", "species_10519963" ], "modifiers": [ [ "species_10510588", "catalyst" ] ], "additional_components": [ "Q19425", "WBGene00008774", "species_29420", "G5EGB3", "WBGene00012497", "Q22743", "WBGene00006414", "species_29438", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "P91040", "WBGene00015697", "Q95Q95", "WBGene00002583", "Q68TI8", "WBGene00000911", "P34443", "WBGene00010038", "P34443", "WBGene00010038", "species_29420", "Q19425", "WBGene00008774", "G5EGB3", "WBGene00012497", "Q22743", "WBGene00006414", "species_29438", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "P91040", "WBGene00015697", "Q95Q95", "WBGene00002583", "Q68TI8", "WBGene00000911", "Q19425", "WBGene00008774", "species_29420", "G5EGB3", "WBGene00012497", "Q22743", "WBGene00006414", "species_29438", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "P91040", "WBGene00015697", "Q95Q95", "WBGene00002583", "Q68TI8", "WBGene00000911", "P34443", "WBGene00010038" ] }, "reaction_10553998": { "compartment": "compartment_70101", "id": "reaction_10553998", "reactome": "R-CEL-5631941", "name": "SESN1,2,3 bind AMPK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10553986", "species_10519954" ], "products": [ "species_10553996" ], "modifiers": [], "additional_components": [ "WBGene00022279", "species_76577", "Q9XUY2", "WBGene00010115", "P45894", "WBGene00019801", "Q95ZQ4", "WBGene00020142", "A0A1T5HUK9", "WBGene00013732", "H2L0K0", "WBGene00020135", "O02168", "WBGene00020633", "Q9N501", "WBGene00021527", "species_76577", "Q9XUY2", "WBGene00010115", "P45894", "WBGene00019801", "Q95ZQ4", "WBGene00020142", "A0A1T5HUK9", "WBGene00013732", "H2L0K0", "WBGene00020135", "O02168", "WBGene00020633", "Q9N501", "WBGene00021527", "Q9N4D6", "WBGene00022279" ] }, "reaction_10503263": { "compartment": "compartment_5460", "id": "reaction_10503263", "reactome": "R-CEL-70609", "name": "glutamine + H2O => glutamate + NH4+ [GLS]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113522", "species_113521" ], "products": [ "species_113561", "species_113552" ], "modifiers": [ [ "species_10503260", "catalyst" ] ], "additional_components": [ "U4PRW7", "WBGene00007480", "Q19013", "WBGene00008435", "Q93650", "WBGene00009271" ] }, "reaction_10563027": { "compartment": "compartment_70101", "id": "reaction_10563027", "reactome": "R-CEL-6803875", "name": "SFN dimer binds CDK1 and CCNB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10563023", "species_10507049" ], "products": [ "species_10563025" ], "modifiers": [], "additional_components": [ "Q10653", "WBGene00000865", "Q9BLB5", "WBGene00000867", "O45926", "WBGene00000866", "P34556", "WBGene00000405", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "Q10653", "WBGene00000865", "Q9BLB5", "WBGene00000867", "O45926", "WBGene00000866", "P34556", "WBGene00000405" ] }, "reaction_10563029": { "compartment": "compartment_70101", "id": "reaction_10563029", "reactome": "R-CEL-6803890", "name": "SFN dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10507047" ], "products": [ "species_10507049" ], "modifiers": [], "additional_components": [ "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "P41932", "WBGene00003920", "Q20655", "WBGene00001502" ] }, "reaction_10569796": { "compartment": "compartment_7660", "id": "reaction_10569796", "reactome": "R-CEL-8952996", "name": "E2F7 forms homodimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10569792" ], "products": [ "species_10569794" ], "modifiers": [], "additional_components": [ "WBGene00009899", "Q20619", "WBGene00009899" ] }, "reaction_10569802": { "compartment": "compartment_7660", "id": "reaction_10569802", "reactome": "R-CEL-8953013", "name": "E2F7 binds E2F8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10569798", "species_10569792" ], "products": [ "species_10569800" ], "modifiers": [], "additional_components": [ "WBGene00009899", "WBGene00009899", "Q20619", "WBGene00009899" ] }, "reaction_10569806": { "compartment": "compartment_7660", "id": "reaction_10569806", "reactome": "R-CEL-8953037", "name": "E2F8 forms homodimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10569798" ], "products": [ "species_10569804" ], "modifiers": [], "additional_components": [ "WBGene00009899", "Q20619", "WBGene00009899" ] }, "reaction_10517733": { "compartment": "compartment_984", "id": "reaction_10517733", "reactome": "R-CEL-265456", "name": "NPC1L1 inactivation by ezetimibe", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_265479", "species_10517729" ], "products": [ "species_10517731" ], "modifiers": [], "additional_components": [ "P34389", "WBGene00003562", "Q19127", "WBGene00003561", "P34389", "WBGene00003562", "Q19127", "WBGene00003561", "species_265479" ] }, "reaction_10569030": { "compartment": "compartment_70101", "id": "reaction_10569030", "reactome": "R-CEL-8950780", "name": "p-Y705-STAT3 binds p-Y693-STAT4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10568972", "species_10531883" ], "products": [ "species_10569014" ], "modifiers": [], "additional_components": [ "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111" ] }, "reaction_10569018": { "compartment": "compartment_70101", "id": "reaction_10569018", "reactome": "R-CEL-8950724", "name": "p-Y705-STAT3:p-Y693-STAT4 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10569014" ], "products": [ "species_10569016" ], "modifiers": [], "additional_components": [ "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111" ] }, "reaction_10520825": { "compartment": "compartment_984", "id": "reaction_10520825", "reactome": "R-CEL-390641", "name": "ADRA1A,B,D bind ADR,NAd", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10519575", "species_390627" ], "products": [ "species_10519581" ], "modifiers": [ [ "species_10520823", "catalyst" ], [ "species_10520821", "inhibitor" ] ], "additional_components": [ "WBGene00008890", "species_209794", "species_209789", "species_209794", "species_209789", "G5EBX8", "WBGene00008890", "G5EBX8", "WBGene00008890", "G5EBX8", "WBGene00008890" ] }, "reaction_10520831": { "compartment": "compartment_984", "id": "reaction_10520831", "reactome": "R-CEL-390663", "name": "ADRA2A,B,C bind ADR,NAd", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_390627", "species_10519747" ], "products": [ "species_10519749" ], "modifiers": [], "additional_components": [ "species_209794", "species_209789", "O02213", "WBGene00004777", "Q19084", "WBGene00017157", "O02213", "WBGene00004777", "Q19084", "WBGene00017157", "species_209794", "species_209789" ] }, "reaction_10512688": { "compartment": "compartment_7660", "id": "reaction_10512688", "reactome": "R-CEL-187959", "name": "Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10512672" ], "products": [ "species_113582", "species_10512685" ], "modifiers": [ [ "species_10512672", "catalyst" ] ], "additional_components": [ "O61847", "WBGene00019362", "A5HWA8", "WBGene00001162", "O61847", "WBGene00019362", "A5HWA8", "WBGene00001162", "O61847", "WBGene00019362", "A5HWA8", "WBGene00001162" ] }, "reaction_10512674": { "compartment": "compartment_7660", "id": "reaction_10512674", "reactome": "R-CEL-187937", "name": "Association of Cyclin A:phospho-Cdk2(Thr 160) with E2F1/E2F3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502089", "species_10502278" ], "products": [ "species_10512672" ], "modifiers": [], "additional_components": [ "WBGene00001162", "O61847", "WBGene00019362", "O61847", "WBGene00019362", "A5HWA8", "WBGene00001162" ] }, "reaction_10565857": { "compartment": "compartment_70101", "id": "reaction_10565857", "reactome": "R-CEL-8857925", "name": "Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10513555" ], "products": [ "species_10565838", "species_29370" ], "modifiers": [ [ "species_10565854", "catalyst" ], [ "species_1806240", "catalyst" ] ], "additional_components": [] }, "reaction_10537250": { "compartment": "compartment_876", "id": "reaction_10537250", "reactome": "R-CEL-1676082", "name": "PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_392417" ], "products": [ "species_29370", "species_179856" ], "modifiers": [ [ "species_10537051", "catalyst" ] ], "additional_components": [ "WBGene00004087" ] }, "reaction_10537082": { "compartment": "compartment_876", "id": "reaction_10537082", "reactome": "R-CEL-1675776", "name": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806240", "species_113592" ], "products": [ "species_29370", "species_179856" ], "modifiers": [ [ "species_10537079", "catalyst" ] ], "additional_components": [ "Q9BL73", "WBGene00004088" ] }, "reaction_10564090": { "compartment": "compartment_70101", "id": "reaction_10564090", "reactome": "R-CEL-6811504", "name": "AKT1 dephosphorylation by PP2A-B56-beta,gamma", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10513843" ], "products": [ "species_10520798", "species_29372" ], "modifiers": [ [ "species_10564085", "catalyst" ], [ "species_1806240", "inhibitor" ] ], "additional_components": [ "Q9XTG7", "WBGene00000103", "G4S4W1", "WBGene00016980", "Q17941", "WBGene00000102", "G4S4W1", "WBGene00016980", "Q17941", "WBGene00000102", "Q9XTG7", "WBGene00000103", "O18178", "WBGene00012348", "A9UJN4", "WBGene00007554" ] }, "reaction_10543901": { "compartment": "compartment_70101", "id": "reaction_10543901", "reactome": "R-CEL-2316434", "name": "PI3K phosphorylates PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10543898", "catalyst" ] ], "additional_components": [ "Q94125", "WBGene00000090", "G5EDP9", "WBGene00000001", "P29355", "WBGene00004774", "G5EDJ4", "WBGene00004928", "E6N0V1", "WBGene00018819", "species_29438", "Q03206", "ced-10", "Q94124", "WBGene00004287", "Q9BL44", "WBGene00022177", "Q9XVQ7", "WBGene00008711", "A0A486WY88", "WBGene00010631", "species_1254400", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "A0A1I6CMA1", "WBGene00020678", "G5EGT9", "WBGene00003007", "P24348", "WBGene00002299", "species_179838", "Q9N413", "WBGene00004249" ] }, "reaction_10513621": { "compartment": "compartment_70101", "id": "reaction_10513621", "reactome": "R-CEL-195283", "name": "Phosphorylation of phospho- (Ser45, Thr41) beta-catenin at Ser37 by GSK-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10513614", "species_113592" ], "products": [ "species_29370", "species_10513618" ], "modifiers": [ [ "species_10513614", "catalyst" ] ], "additional_components": [ "Q21227", "WBGene00000156", "Q9U2Q9", "WBGene00001746", "Q09595", "WBGene00010991", "Q93372", "WBGene00010991", "P42168", "WBGene00002202", "O62090", "WBGene00004202", "O44326", "WBGene00001979", "O44326", "WBGene00001979", "Q21227", "WBGene00000156", "Q9U2Q9", "WBGene00001746", "Q09595", "WBGene00010991", "Q93372", "WBGene00010991", "P42168", "WBGene00002202", "O62090", "WBGene00004202", "Q21227", "WBGene00000156", "Q9U2Q9", "WBGene00001746", "Q09595", "WBGene00010991", "Q93372", "WBGene00010991", "P42168", "WBGene00002202", "O62090", "WBGene00004202", "O44326", "WBGene00001979" ] }, "reaction_10513640": { "compartment": "compartment_70101", "id": "reaction_10513640", "reactome": "R-CEL-195318", "name": "Phosphorylation of beta-catenin at Ser45 by CK1 alpha", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10513635" ], "products": [ "species_29370", "species_10513625" ], "modifiers": [ [ "species_10513635", "catalyst" ] ], "additional_components": [ "O44326", "WBGene00001979", "Q21227", "WBGene00000156", "Q9U2Q9", "WBGene00001746", "Q09595", "WBGene00010991", "Q93372", "WBGene00010991", "P42168", "WBGene00002202", "O62090", "WBGene00004202", "Q21227", "WBGene00000156", "Q9U2Q9", "WBGene00001746", "Q09595", "WBGene00010991", "Q93372", "WBGene00010991", "P42168", "WBGene00002202", "O62090", "WBGene00004202", "O44326", "WBGene00001979", "O44326", "WBGene00001979", "Q21227", "WBGene00000156", "Q9U2Q9", "WBGene00001746", "Q09595", "WBGene00010991", "Q93372", "WBGene00010991", "P42168", "WBGene00002202", "O62090", "WBGene00004202" ] }, "reaction_10513628": { "compartment": "compartment_70101", "id": "reaction_10513628", "reactome": "R-CEL-195287", "name": "Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10513625" ], "products": [ "species_10513614", "species_29370" ], "modifiers": [ [ "species_10513625", "catalyst" ] ], "additional_components": [ "Q21227", "WBGene00000156", "Q9U2Q9", "WBGene00001746", "Q09595", "WBGene00010991", "Q93372", "WBGene00010991", "P42168", "WBGene00002202", "O62090", "WBGene00004202", "O44326", "WBGene00001979", "Q21227", "WBGene00000156", "Q9U2Q9", "WBGene00001746", "Q09595", "WBGene00010991", "Q93372", "WBGene00010991", "P42168", "WBGene00002202", "O62090", "WBGene00004202", "O44326", "WBGene00001979", "Q21227", "WBGene00000156", "Q9U2Q9", "WBGene00001746", "Q09595", "WBGene00010991", "Q93372", "WBGene00010991", "P42168", "WBGene00002202", "O62090", "WBGene00004202", "O44326", "WBGene00001979" ] }, "reaction_10513631": { "compartment": "compartment_70101", "id": "reaction_10513631", "reactome": "R-CEL-195300", "name": "Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10513618" ], "products": [ "species_10513598", "species_29370" ], "modifiers": [ [ "species_10513618", "catalyst" ] ], "additional_components": [ "O44326", "WBGene00001979", "Q21227", "WBGene00000156", "Q9U2Q9", "WBGene00001746", "Q09595", "WBGene00010991", "Q93372", "WBGene00010991", "P42168", "WBGene00002202", "O62090", "WBGene00004202", "Q21227", "WBGene00000156", "Q9U2Q9", "WBGene00001746", "Q09595", "WBGene00010991", "Q93372", "WBGene00010991", "P42168", "WBGene00002202", "O62090", "WBGene00004202", "O44326", "WBGene00001979", "O44326", "WBGene00001979", "Q21227", "WBGene00000156", "Q9U2Q9", "WBGene00001746", "Q09595", "WBGene00010991", "Q93372", "WBGene00010991", "P42168", "WBGene00002202", "O62090", "WBGene00004202" ] }, "reaction_10568784": { "compartment": "compartment_7660", "id": "reaction_10568784", "reactome": "R-CEL-8944349", "name": "TLE tetramers bind TCF/LEF at WNT promoters", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10547166", "species_10568780" ], "products": [ "species_10568782" ], "modifiers": [], "additional_components": [ "O02482", "WBGene00006773", "Q10666", "WBGene00004077", "Q10666", "WBGene00004077", "O02482", "WBGene00006773" ] }, "reaction_10549443": { "compartment": "compartment_7660", "id": "reaction_10549443", "reactome": "R-CEL-4641229", "name": "TLE oligomerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10547150" ], "products": [ "species_10547166" ], "modifiers": [], "additional_components": [ "WBGene00006773", "O02482", "WBGene00006773" ] }, "reaction_10551337": { "compartment": "compartment_7660", "id": "reaction_10551337", "reactome": "R-CEL-5334050", "name": "TCF7L2/TCF7L1 bind CTBP1 to repress WNT target genes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546301", "species_10547139" ], "products": [ "species_10551335" ], "modifiers": [], "additional_components": [ "WBGene00006424", "WBGene00004077", "Q10666", "WBGene00004077", "Q20595", "WBGene00006424" ] }, "reaction_10542756": { "compartment": "compartment_70101", "id": "reaction_10542756", "reactome": "R-CEL-2130279", "name": "Association of beta-catenin with the RBX1:SCF(beta-TrCP1) ubiquitin ligase complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10516333", "species_10513603" ], "products": [ "species_10542754" ], "modifiers": [], "additional_components": [ "G5ECU1", "WBGene00004807", "Q17389", "WBGene00000836", "Q23457", "WBGene00004320", "Q21227", "WBGene00000156", "Q9U2Q9", "WBGene00001746", "Q09595", "WBGene00010991", "Q93372", "WBGene00010991", "P42168", "WBGene00002202", "O62090", "WBGene00004202", "O44326", "WBGene00001979", "Q21227", "WBGene00000156", "Q9U2Q9", "WBGene00001746", "Q09595", "WBGene00010991", "Q93372", "WBGene00010991", "P42168", "WBGene00002202", "O62090", "WBGene00004202", "O44326", "WBGene00001979", "G5ECU1", "WBGene00004807", "Q17389", "WBGene00000836", "Q23457", "WBGene00004320" ] }, "reaction_10513637": { "compartment": "compartment_70101", "id": "reaction_10513637", "reactome": "R-CEL-195304", "name": "Association of beta-catenin with the destruction complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10513587", "species_10513633" ], "products": [ "species_10513635" ], "modifiers": [], "additional_components": [ "Q21227", "WBGene00000156", "Q9U2Q9", "WBGene00001746", "Q09595", "WBGene00010991", "Q93372", "WBGene00010991", "P42168", "WBGene00002202", "O62090", "WBGene00004202", "WBGene00001979", "O44326", "WBGene00001979", "Q21227", "WBGene00000156", "Q9U2Q9", "WBGene00001746", "Q09595", "WBGene00010991", "Q93372", "WBGene00010991", "P42168", "WBGene00002202", "O62090", "WBGene00004202" ] }, "reaction_10550824": { "compartment": "compartment_70101", "id": "reaction_10550824", "reactome": "R-CEL-5229343", "name": "AXIN is phosphorylated in the destruction complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10515030" ], "products": [ "species_29370", "species_10513587" ], "modifiers": [ [ "species_10515030", "catalyst" ] ], "additional_components": [ "Q21227", "WBGene00000156", "Q9U2Q9", "WBGene00001746", "Q09595", "WBGene00010991", "Q93372", "WBGene00010991", "P42168", "WBGene00002202", "O62090", "WBGene00004202", "Q21227", "WBGene00000156", "Q9U2Q9", "WBGene00001746", "Q09595", "WBGene00010991", "Q93372", "WBGene00010991", "P42168", "WBGene00002202", "O62090", "WBGene00004202", "Q21227", "WBGene00000156", "Q9U2Q9", "WBGene00001746", "Q09595", "WBGene00010991", "Q93372", "WBGene00010991", "P42168", "WBGene00002202", "O62090", "WBGene00004202" ] }, "reaction_10513608": { "compartment": "compartment_70101", "id": "reaction_10513608", "reactome": "R-CEL-195275", "name": "Phosphorylation of APC component of the destruction complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10513598", "species_113592" ], "products": [ "species_29370", "species_10513603" ], "modifiers": [ [ "species_10513598", "catalyst" ] ], "additional_components": [ "Q21227", "WBGene00000156", "Q9U2Q9", "WBGene00001746", "Q09595", "WBGene00010991", "Q93372", "WBGene00010991", "P42168", "WBGene00002202", "O62090", "WBGene00004202", "O44326", "WBGene00001979", "Q21227", "WBGene00000156", "Q9U2Q9", "WBGene00001746", "Q09595", "WBGene00010991", "Q93372", "WBGene00010991", "P42168", "WBGene00002202", "O62090", "WBGene00004202", "O44326", "WBGene00001979", "Q21227", "WBGene00000156", "Q9U2Q9", "WBGene00001746", "Q09595", "WBGene00010991", "Q93372", "WBGene00010991", "P42168", "WBGene00002202", "O62090", "WBGene00004202", "O44326", "WBGene00001979" ] }, "reaction_10513610": { "compartment": "compartment_70101", "id": "reaction_10513610", "reactome": "R-CEL-195280", "name": "Dissociation of beta-catenin from Axin and association of beta catenin with phospho-(20 aa) APC in the detruction complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10513603" ], "products": [ "species_10513603" ], "modifiers": [], "additional_components": [ "Q21227", "WBGene00000156", "Q9U2Q9", "WBGene00001746", "Q09595", "WBGene00010991", "Q93372", "WBGene00010991", "P42168", "WBGene00002202", "O62090", "WBGene00004202", "O44326", "WBGene00001979", "Q21227", "WBGene00000156", "Q9U2Q9", "WBGene00001746", "Q09595", "WBGene00010991", "Q93372", "WBGene00010991", "P42168", "WBGene00002202", "O62090", "WBGene00004202", "O44326", "WBGene00001979" ] }, "reaction_10542762": { "compartment": "compartment_70101", "id": "reaction_10542762", "reactome": "R-CEL-2130282", "name": "Degradation of ubiquitinated beta catenin by the proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10542758" ], "products": [ "species_10516333", "species_10542760", "species_10502375" ], "modifiers": [ [ "species_10502572", "catalyst" ] ], "additional_components": [ "Q21227", "WBGene00000156", "Q9U2Q9", "WBGene00001746", "Q09595", "WBGene00010991", "Q93372", "WBGene00010991", "P42168", "WBGene00002202", "O62090", "WBGene00004202", "O44326", "WBGene00001979", "G5ECU1", "WBGene00004807", "Q17389", "WBGene00000836", "Q23457", "WBGene00004320", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "G5ECU1", "WBGene00004807", "Q17389", "WBGene00000836", "Q23457", "WBGene00004320", "Q21227", "WBGene00000156", "Q9U2Q9", "WBGene00001746", "Q09595", "WBGene00010991", "Q93372", "WBGene00010991", "P42168", "WBGene00002202", "O62090", "WBGene00004202", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "P91477", "WBGene00003950", "Q95PZ7", "WBGene00013435", "Q18115", "WBGene00004459", "O62102", "WBGene00003948", "O17071", "WBGene00004504", "Q10920", "WBGene00016623", "P34286", "WBGene00003952", "Q9XTT9", "WBGene00004506", "Q23449", "WBGene00004468", "Q95005", "WBGene00003925", "P46502", "WBGene00004503", "O61792", "WBGene00004464", "O17586", "WBGene00003922", "O76371", "WBGene00004505", "Q20585", "WBGene00004463", "Q95008", "WBGene00003926", "Q18787", "WBGene00004501", "Q20058", "WBGene00009445", "Q9N599", "WBGene00003924", "O16368", "WBGene00004502", "O61742", "WBGene00004466", "Q09583", "WBGene00003928", "Q966I8", "WBGene00003947", "Q04908", "WBGene00004460", "Q9XUV0", "WBGene00003951", "Q27488", "WBGene00003923", "Q9GZH5", "WBGene00004458", "O44156", "WBGene00003927", "Q22253", "WBGene00004465", "O76577", "WBGene00004467", "P90868", "WBGene00003953", "Q19324", "WBGene00004461", "Q17971", "WBGene00007588", "Q23237", "WBGene00003949", "Q20938", "WBGene00004462" ] }, "reaction_10542764": { "compartment": "compartment_70101", "id": "reaction_10542764", "reactome": "R-CEL-2130286", "name": "Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502375", "species_10542754" ], "products": [ "species_10542758" ], "modifiers": [], "additional_components": [ "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "Q21227", "WBGene00000156", "Q9U2Q9", "WBGene00001746", "Q09595", "WBGene00010991", "Q93372", "WBGene00010991", "P42168", "WBGene00002202", "O62090", "WBGene00004202", "O44326", "WBGene00001979", "G5ECU1", "WBGene00004807", "Q17389", "WBGene00000836", "Q23457", "WBGene00004320", "Q21227", "WBGene00000156", "Q9U2Q9", "WBGene00001746", "Q09595", "WBGene00010991", "Q93372", "WBGene00010991", "P42168", "WBGene00002202", "O62090", "WBGene00004202", "O44326", "WBGene00001979", "G5ECU1", "WBGene00004807", "Q17389", "WBGene00000836", "Q23457", "WBGene00004320", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727" ] }, "reaction_10569984": { "compartment": "compartment_70101", "id": "reaction_10569984", "reactome": "R-CEL-8955760", "name": "PGM2L1:Mg2+ phosphorylates G6P to G1,6BP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30537", "species_29800" ], "products": [ "species_70106", "species_8955759", "species_29728" ], "modifiers": [ [ "species_10502853", "catalyst" ] ], "additional_components": [ "O45934", "WBGene00012803", "species_114632" ] }, "reaction_10504330": { "compartment": "compartment_70101", "id": "reaction_10504330", "reactome": "R-CEL-71802", "name": "D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_29512" ], "products": [ "species_29370", "species_30533" ], "modifiers": [ [ "species_10504327", "catalyst" ], [ "species_30533", "catalyst" ] ], "additional_components": [ "Q21122", "WBGene00019295", "Q9N590", "WBGene00022456" ] }, "reaction_10502842": { "compartment": "compartment_70101", "id": "reaction_10502842", "reactome": "R-CEL-70262", "name": "Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_30533" ], "products": [ "species_29372", "species_29512" ], "modifiers": [ [ "species_10502839", "catalyst" ] ], "additional_components": [ "Q9N590", "WBGene00022456", "Q21122", "WBGene00019295" ] }, "reaction_10504194": { "compartment": "compartment_70101", "id": "reaction_10504194", "reactome": "R-CEL-71660", "name": "2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30485" ], "products": [ "species_29356", "species_29492" ], "modifiers": [ [ "species_10503109", "catalyst" ] ], "additional_components": [ "Q27527", "WBGene00011884", "species_114632" ] }, "reaction_10557538": { "compartment": "compartment_12045", "id": "reaction_10557538", "reactome": "R-CEL-5696021", "name": "ADPGK:Mg2+ phosphorylates Glc to G6P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29370", "species_70113" ], "products": [ "species_30537", "species_76577" ], "modifiers": [ [ "species_10557535", "catalyst" ] ], "additional_components": [ "species_114632", "Q86S40", "WBGene00016810" ] }, "reaction_10504004": { "compartment": "compartment_70101", "id": "reaction_10504004", "reactome": "R-CEL-71496", "name": "D-fructose 1,6-bisphosphate <=> dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30014" ], "products": [ "species_29578", "species_75970" ], "modifiers": [ [ "species_10503999", "catalyst" ] ], "additional_components": [ "P54216", "WBGene00011474", "P46563", "WBGene00017166" ] }, "reaction_10503048": { "compartment": "compartment_70101", "id": "reaction_10503048", "reactome": "R-CEL-70467", "name": "D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_29512" ], "products": [ "species_30014", "species_29370" ], "modifiers": [ [ "species_10503045", "catalyst" ], [ "species_30533", "catalyst" ], [ "species_29370", "catalyst" ], [ "species_76577", "catalyst" ], [ "species_113592", "inhibitor" ], [ "species_76190", "inhibitor" ] ], "additional_components": [ "Q9TZL8", "WBGene00022199", "Q27483", "WBGene00008230" ] }, "reaction_10511375": { "compartment": "compartment_13231", "id": "reaction_10511375", "reactome": "R-CEL-170825", "name": "glucokinase [nucleoplasm] => glucokinase [cytosol]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10511373" ], "products": [ "species_10502937" ], "modifiers": [], "additional_components": [ "Q19440", "WBGene00008780", "Q9N4A5", "WBGene00022306", "Q9XU15", "WBGene00010416", "Q9N4A5", "WBGene00022306", "Q9XU15", "WBGene00010416", "Q19440", "WBGene00008780" ] }, "reaction_10502958": { "compartment": "compartment_70101", "id": "reaction_10502958", "reactome": "R-CEL-70420", "name": "HK1,2,3,GCK phosphorylate Glc to form G6P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_70113" ], "products": [ "species_70106", "species_29370", "species_30537" ], "modifiers": [ [ "species_10502955", "catalyst" ] ], "additional_components": [ "Q19440", "WBGene00008780", "Q9N4A5", "WBGene00022306", "Q9XU15", "WBGene00010416" ] }, "reaction_10504334": { "compartment": "compartment_70101", "id": "reaction_10504334", "reactome": "R-CEL-71850", "name": "1,3-bisphospho-D-glycerate + ADP <=> 3-phospho-D-glycerate + ATP", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29370", "species_29800" ], "products": [ "species_113592", "species_29728" ], "modifiers": [ [ "species_10503093", "catalyst" ] ], "additional_components": [ "species_114632", "P91427", "WBGene00020185" ] }, "reaction_10502997": { "compartment": "compartment_70101", "id": "reaction_10502997", "reactome": "R-CEL-70449", "name": "D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29372", "species_29578", "species_29360" ], "products": [ "species_70106", "species_29800", "species_73473" ], "modifiers": [ [ "species_10502994", "catalyst" ] ], "additional_components": [ "P04970", "WBGene00001683", "P17329", "WBGene00001684", "P17330", "WBGene00001685", "P17331", "WBGene00001686" ] }, "reaction_10562107": { "compartment": "compartment_70101", "id": "reaction_10562107", "reactome": "R-CEL-6799604", "name": "GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_449701" ], "products": [ "species_29512", "species_31633" ], "modifiers": [ [ "species_10562104", "catalyst" ] ], "additional_components": [ "Q9XVJ2", "WBGene00011399" ] }, "reaction_10504221": { "compartment": "compartment_70101", "id": "reaction_10504221", "reactome": "R-CEL-71670", "name": "phosphoenolpyruvate + ADP => pyruvate + ATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29370", "species_29492" ], "products": [ "species_113592", "species_29398" ], "modifiers": [ [ "species_10504218", "catalyst" ], [ "species_30014", "catalyst" ], [ "species_76183", "inhibitor" ], [ "species_29358", "inhibitor" ], [ "species_30389", "inhibitor" ] ], "additional_components": [ "species_114632", "species_74126", "B7WNA0", "WBGene00009126", "Q23539", "WBGene00014001" ] }, "reaction_10503007": { "compartment": "compartment_70101", "id": "reaction_10503007", "reactome": "R-CEL-70454", "name": "dihydroxyacetone phosphate <=> D-glyceraldehyde 3-phosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_75970" ], "products": [ "species_29578" ], "modifiers": [ [ "species_10503004", "catalyst" ] ], "additional_components": [ "Q10657", "WBGene00006601" ] }, "reaction_10529025": { "compartment": "compartment_5460", "id": "reaction_10529025", "reactome": "R-CEL-916855", "name": "PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_916850", "species_113594" ], "products": [ "species_880046", "species_113552" ], "modifiers": [ [ "species_10529022", "catalyst" ] ], "additional_components": [ "CHEBI:33739", "Q21217", "WBGene00001794" ] }, "reaction_10528302": { "compartment": "compartment_5460", "id": "reaction_10528302", "reactome": "R-CEL-888548", "name": "ALDH5A1 dehydrogenates SUCCSA to SUCCA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113526", "species_880046", "species_113521" ], "products": [ "species_113529", "species_29362", "species_113536" ], "modifiers": [ [ "species_10528299", "catalyst" ] ], "additional_components": [ "O02266", "WBGene00000113" ] }, "reaction_10550736": { "compartment": "compartment_7660", "id": "reaction_10550736", "reactome": "R-CEL-5225602", "name": "WDR5 binds Me2sR3-replicative histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10550011", "species_10550698" ], "products": [ "species_10550734" ], "modifiers": [], "additional_components": [ "WBGene00006474", "Q17963", "WBGene00006474" ] }, "reaction_10550706": { "compartment": "compartment_7660", "id": "reaction_10550706", "reactome": "R-CEL-5218952", "name": "PRMT5:WDR77, PRMT7 methylate arginine-3 of histone H3 (H3R2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10546551" ], "products": [ "species_77502", "species_10550698" ], "modifiers": [ [ "species_10550703", "catalyst" ] ], "additional_components": [ "WBGene00012298" ] }, "reaction_10554499": { "compartment": "compartment_7660", "id": "reaction_10554499", "reactome": "R-CEL-5661126", "name": "PRMT1,PRMT6 methylate methyl-lysine-4 of histone H4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10550424" ], "products": [ "species_77502", "species_10554497" ], "modifiers": [ [ "species_10546564", "catalyst" ] ], "additional_components": [ "WBGene00001875", "WBGene00001875", "WBGene00013766" ] }, "reaction_10550740": { "compartment": "compartment_7660", "id": "reaction_10550740", "reactome": "R-CEL-5225649", "name": "RBBP7 binds histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10517096", "species_10546551" ], "products": [ "species_10550738" ], "modifiers": [ [ "species_10550698", "inhibitor" ] ], "additional_components": [ "P90916", "WBGene00003036", "P90917", "WBGene00004312", "P90916", "WBGene00003036", "P90917", "WBGene00004312" ] }, "reaction_10550506": { "compartment": "compartment_7660", "id": "reaction_10550506", "reactome": "R-CEL-5205867", "name": "PRMT1 methylates arginine-12 of histone H2A (H2AR11)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10550491" ], "products": [ "species_77502", "species_10550504" ], "modifiers": [ [ "species_10546564", "catalyst" ] ], "additional_components": [ "WBGene00013766" ] }, "reaction_10550427": { "compartment": "compartment_7660", "id": "reaction_10550427", "reactome": "R-CEL-5205798", "name": "PRMT1,PRMT6 methylate arginine-4 of histone H4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10506929" ], "products": [ "species_77502", "species_10550424" ], "modifiers": [ [ "species_10546564", "catalyst" ] ], "additional_components": [ "WBGene00001875", "WBGene00001875", "WBGene00013766" ] }, "reaction_10554048": { "compartment": "compartment_70101", "id": "reaction_10554048", "reactome": "R-CEL-5634802", "name": "MECOM (KMT8E), PRDM16 (KMT8F) methylate lysine-10 of replicative histone H3 (H3K9)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71284", "species_10554034" ], "products": [ "species_10554038", "species_71285" ], "modifiers": [ [ "species_10554043", "catalyst" ] ], "additional_components": [ "WBGene00001207" ] }, "reaction_10554160": { "compartment": "compartment_7660", "id": "reaction_10554160", "reactome": "R-CEL-5638157", "name": "WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C), ASH1L methylate methyl-lysine-37 of histone H3 (H3K36)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10549582" ], "products": [ "species_77502", "species_10554153" ], "modifiers": [ [ "species_10549759", "catalyst" ] ], "additional_components": [ "Q23084", "WBGene00022499", "Q8I4F7", "WBGene00044070", "Q9XV44", "WBGene00009370", "Q09415", "WBGene00011068" ] }, "reaction_10549762": { "compartment": "compartment_7660", "id": "reaction_10549762", "reactome": "R-CEL-4827383", "name": "WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C) methylate lysine-37 of histone H3 (H3K36)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10546551" ], "products": [ "species_77502", "species_10549582" ], "modifiers": [ [ "species_10549759", "catalyst" ] ], "additional_components": [ "Q23084", "WBGene00022499", "Q8I4F7", "WBGene00044070", "Q9XV44", "WBGene00009370", "Q09415", "WBGene00011068" ] }, "reaction_10554178": { "compartment": "compartment_7660", "id": "reaction_10554178", "reactome": "R-CEL-5649764", "name": "DOT1L (KMT4) methylates methyl-lysine-80 of histone H3 (H3K79)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10554165" ], "products": [ "species_77502", "species_10554170" ], "modifiers": [ [ "species_10554175", "catalyst" ] ], "additional_components": [ "WBGene00021474" ] }, "reaction_10550023": { "compartment": "compartment_7660", "id": "reaction_10550023", "reactome": "R-CEL-5159245", "name": "SETD3, SETD7 (KMT7), WHSC1L1 (KMT3F), Core MLL complex methylate lysine-5 of histone H3 (H3K4)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10546551" ], "products": [ "species_77502", "species_10546549" ], "modifiers": [ [ "species_10550020", "catalyst" ] ], "additional_components": [ "Q9BL48", "WBGene00022173", "Q10661", "WBGene00001088", "G5EFZ3", "WBGene00012458", "Q09309", "WBGene00017683", "Q18221", "WBGene00004782", "G5EGI1", "WBGene00011729", "Q17963", "WBGene00006474" ] }, "reaction_10552342": { "compartment": "compartment_7660", "id": "reaction_10552342", "reactome": "R-CEL-5423038", "name": "SETD8 (KMT5A) methylates lysine-21 of histone H4 (H4K20)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10506929" ], "products": [ "species_77502", "species_10543366" ], "modifiers": [ [ "species_10543801", "catalyst" ] ], "additional_components": [ "WBGene00001875", "WBGene00001875", "WBGene00004781" ] }, "reaction_10554185": { "compartment": "compartment_7660", "id": "reaction_10554185", "reactome": "R-CEL-5649799", "name": "DOT1L (KMT4) methylates dimethyl-lysine-80 of histone H3 (H3K79)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10554170" ], "products": [ "species_77502", "species_10554183" ], "modifiers": [ [ "species_10554175", "catalyst" ] ], "additional_components": [ "WBGene00021474" ] }, "reaction_10550985": { "compartment": "compartment_7660", "id": "reaction_10550985", "reactome": "R-CEL-5244692", "name": "Core MLL complex, SMYD3, PRDM9 methylate dimethyl-lysine-5 of histone H3 (H3K4)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10549629" ], "products": [ "species_77502", "species_10550978" ], "modifiers": [ [ "species_10550982", "catalyst" ], [ "species_10550471", "inhibitor" ] ], "additional_components": [ "Q10661", "WBGene00001088", "G5EFZ3", "WBGene00012458", "Q09309", "WBGene00017683", "Q18221", "WBGene00004782", "G5EGI1", "WBGene00011729", "Q17963", "WBGene00006474", "Q09415", "WBGene00011068" ] }, "reaction_10549737": { "compartment": "compartment_7660", "id": "reaction_10549737", "reactome": "R-CEL-4827382", "name": "SUV39H1 (KMT1A), SUV39H2 (KTM1B), SETDB1 (KMT1E), SETDB2 (KMT1F) methylate dimethyl-lysine-10 of histone H3 (H3K9)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10549601" ], "products": [ "species_77502", "species_10549722" ], "modifiers": [ [ "species_10549734", "catalyst" ] ], "additional_components": [ "P34544", "WBGene00019883", "Q18221", "WBGene00004782" ] }, "reaction_10554187": { "compartment": "compartment_7660", "id": "reaction_10554187", "reactome": "R-CEL-5649801", "name": "DOT1L (KMT4) methylates lysine-80 of histone H3 (H3K79)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10546551" ], "products": [ "species_77502", "species_10554165" ], "modifiers": [ [ "species_10554175", "catalyst" ] ], "additional_components": [ "WBGene00021474" ] }, "reaction_10554110": { "compartment": "compartment_7660", "id": "reaction_10554110", "reactome": "R-CEL-5637686", "name": "WHSC1L1 (KMT3F), Core MLL complex, SMYD3 (KMT3E) methylate methyl-lysine-5 of histone H3 (H3K4)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10546549" ], "products": [ "species_77502", "species_10549629" ], "modifiers": [ [ "species_10554107", "catalyst" ] ], "additional_components": [ "Q9BL48", "WBGene00022173", "Q10661", "WBGene00001088", "G5EFZ3", "WBGene00012458", "Q09309", "WBGene00017683", "Q18221", "WBGene00004782", "G5EGI1", "WBGene00011729", "Q17963", "WBGene00006474", "Q09415", "WBGene00011068" ] }, "reaction_10549670": { "compartment": "compartment_7660", "id": "reaction_10549670", "reactome": "R-CEL-4754187", "name": "KDM6A, KDM6B, KDM7A demethylate Me2K28-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113671", "species_113685", "species_10549648" ], "products": [ "species_29478", "species_10549653", "species_159942", "species_159939" ], "modifiers": [ [ "species_10549667", "catalyst" ] ], "additional_components": [ "Q19760", "WBGene00009089", "Q95QK3", "WBGene00017571", "Q20367", "WBGene00005013", "Q9GYI0", "WBGene00017920" ] }, "reaction_10554473": { "compartment": "compartment_7660", "id": "reaction_10554473", "reactome": "R-CEL-5661114", "name": "KDM2A, KDM2B, KDM4A demethylate Me2K37-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10554153", "species_113671", "species_113685" ], "products": [ "species_10549582", "species_29478", "species_159942", "species_159939" ], "modifiers": [ [ "species_10549596", "catalyst" ] ], "additional_components": [ "Q95Q98", "WBGene00020821", "Q9U297", "WBGene00012982" ] }, "reaction_10549608": { "compartment": "compartment_7660", "id": "reaction_10549608", "reactome": "R-CEL-4724279", "name": "KDM4A, KDM4B, KDM4C, KDM4D demethylate Me2K10-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113671", "species_113685", "species_10549601" ], "products": [ "species_29478", "species_159942", "species_10549603", "species_159939" ], "modifiers": [ [ "species_10549594", "catalyst" ] ], "additional_components": [ "WBGene00012982" ] }, "reaction_10554475": { "compartment": "compartment_7660", "id": "reaction_10554475", "reactome": "R-CEL-5661115", "name": "KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate Me2K10-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113671", "species_113685", "species_10549601" ], "products": [ "species_29478", "species_159942", "species_10549603", "species_159939" ], "modifiers": [ [ "species_10549616", "catalyst" ] ], "additional_components": [ "Q9GYI0", "WBGene00017920", "Q20367", "WBGene00005013" ] }, "reaction_10549643": { "compartment": "compartment_7660", "id": "reaction_10549643", "reactome": "R-CEL-4754181", "name": "KDM5A-D demethylate Me2K5-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10549629", "species_113671", "species_113685" ], "products": [ "species_29478", "species_10546549", "species_159942", "species_159939" ], "modifiers": [ [ "species_10549634", "catalyst" ] ], "additional_components": [ "WBGene00004319" ] }, "reaction_10554477": { "compartment": "compartment_7660", "id": "reaction_10554477", "reactome": "R-CEL-5661116", "name": "KDM5A-D demethylate Me3K5-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113671", "species_113685", "species_10550978" ], "products": [ "species_10549629", "species_29478", "species_159942", "species_159939" ], "modifiers": [ [ "species_10549634", "catalyst" ] ], "additional_components": [ "WBGene00004319" ] }, "reaction_10549619": { "compartment": "compartment_7660", "id": "reaction_10549619", "reactome": "R-CEL-4724284", "name": "KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate MeK10-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113671", "species_113685", "species_10549603" ], "products": [ "species_10546551", "species_29478", "species_159942", "species_159939" ], "modifiers": [ [ "species_10549616", "catalyst" ] ], "additional_components": [ "Q9GYI0", "WBGene00017920", "Q20367", "WBGene00005013" ] }, "reaction_10554484": { "compartment": "compartment_7660", "id": "reaction_10554484", "reactome": "R-CEL-5661120", "name": "KDM4A, KDM4B, KDM4C, KDM4D, MINA demethylate Me3K10-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10549722", "species_113671", "species_113685" ], "products": [ "species_29478", "species_159942", "species_159939", "species_10549601" ], "modifiers": [ [ "species_10549594", "catalyst" ] ], "additional_components": [ "WBGene00012982" ] }, "reaction_10554486": { "compartment": "compartment_7660", "id": "reaction_10554486", "reactome": "R-CEL-5661121", "name": "KDM6A, KDM6B, KDM7A demethylate Me3K28-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10554189", "species_113671", "species_113685" ], "products": [ "species_29478", "species_159942", "species_159939", "species_10549648" ], "modifiers": [ [ "species_10549667", "catalyst" ] ], "additional_components": [ "Q19760", "WBGene00009089", "Q95QK3", "WBGene00017571", "Q20367", "WBGene00005013", "Q9GYI0", "WBGene00017920" ] }, "reaction_10552345": { "compartment": "compartment_7660", "id": "reaction_10552345", "reactome": "R-CEL-5423117", "name": "PHF8 demethylates MeK21-histone H4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113671", "species_10543366", "species_113685" ], "products": [ "species_29478", "species_159942", "species_159939", "species_10506929" ], "modifiers": [ [ "species_10543372", "catalyst" ] ], "additional_components": [ "WBGene00001875", "WBGene00001875", "WBGene00017920" ] }, "reaction_10554488": { "compartment": "compartment_7660", "id": "reaction_10554488", "reactome": "R-CEL-5661122", "name": "JMJD6 demethylates Me2R3-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113671", "species_10550469", "species_113685" ], "products": [ "species_29478", "species_10546774", "species_159942", "species_159939" ], "modifiers": [ [ "species_10549624", "catalyst" ] ], "additional_components": [ "WBGene00004205" ] }, "reaction_10554490": { "compartment": "compartment_7660", "id": "reaction_10554490", "reactome": "R-CEL-5661123", "name": "KDM1A, KDM1B demethylate Me2K5-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10549629" ], "products": [ "species_29478", "species_10546549" ], "modifiers": [ [ "species_10546556", "catalyst" ] ], "additional_components": [ "WBGene00000137" ] }, "reaction_10549627": { "compartment": "compartment_7660", "id": "reaction_10549627", "reactome": "R-CEL-4754176", "name": "JMJD6 demethylates MeR3-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113671", "species_10546774", "species_113685" ], "products": [ "species_10546551", "species_29478", "species_159942", "species_159939" ], "modifiers": [ [ "species_10549624", "catalyst" ] ], "additional_components": [ "WBGene00004205" ] }, "reaction_10554492": { "compartment": "compartment_7660", "id": "reaction_10554492", "reactome": "R-CEL-5661124", "name": "JMJD6 demethylates MeR4-HIST1H4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10550424", "species_113671", "species_113685" ], "products": [ "species_29478", "species_159942", "species_159939", "species_10506929" ], "modifiers": [ [ "species_10549624", "catalyst" ] ], "additional_components": [ "WBGene00001875", "WBGene00001875", "WBGene00004205" ] }, "reaction_10546559": { "compartment": "compartment_7660", "id": "reaction_10546559", "reactome": "R-CEL-3214912", "name": "KDM1A, KDM1B demethylate MeK5-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546549" ], "products": [ "species_10546551", "species_29478" ], "modifiers": [ [ "species_10546556", "catalyst" ] ], "additional_components": [ "WBGene00000137" ] }, "reaction_10549599": { "compartment": "compartment_7660", "id": "reaction_10549599", "reactome": "R-CEL-4722133", "name": "KDM2A, KDM2B, KDM4A demethylate MeK37-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10549582", "species_113671", "species_113685" ], "products": [ "species_10546551", "species_29478", "species_159942", "species_159939" ], "modifiers": [ [ "species_10549596", "catalyst" ] ], "additional_components": [ "Q95Q98", "WBGene00020821", "Q9U297", "WBGene00012982" ] }, "reaction_10554494": { "compartment": "compartment_7660", "id": "reaction_10554494", "reactome": "R-CEL-5661125", "name": "JMJD6 demethylates Me2sR4-HIST1H4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10550476", "species_113671", "species_113685" ], "products": [ "species_10550424", "species_29478", "species_159942", "species_159939" ], "modifiers": [ [ "species_10549624", "catalyst" ] ], "additional_components": [ "WBGene00001875", "WBGene00001875", "WBGene00004205" ] }, "reaction_10547753": { "compartment": "compartment_7660", "id": "reaction_10547753", "reactome": "R-CEL-3662318", "name": "Type B histone acetlytransferase complex acetylates histone H4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113560", "species_10506929" ], "products": [ "species_2485002", "species_10547743" ], "modifiers": [ [ "species_10547750", "catalyst" ] ], "additional_components": [ "WBGene00001875", "WBGene00001875", "Q21484", "WBGene00044069", "P90916", "WBGene00003036", "P90917", "WBGene00004312" ] }, "reaction_10547932": { "compartment": "compartment_7660", "id": "reaction_10547932", "reactome": "R-CEL-3662335", "name": "EP300 acetylates histone H2A, H2B, H3, H4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113560", "species_10547761" ], "products": [ "species_2485002", "species_10547929" ], "modifiers": [ [ "species_10532228", "catalyst" ] ], "additional_components": [ "WBGene00000366" ] }, "reaction_10547276": { "compartment": "compartment_7660", "id": "reaction_10547276", "reactome": "R-CEL-3318415", "name": "ATF2 acetylates histone H2B, H4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113560", "species_10547238" ], "products": [ "species_2485002", "species_10547273" ], "modifiers": [ [ "species_10510845", "catalyst" ] ], "additional_components": [ "P62784", "WBGene00001875", "Q27484", "WBGene00001915", "Q27876", "WBGene00001922", "Q27894", "WBGene00001878", "P04255", "WBGene00001885", "P04255", "WBGene00001885", "Q27484", "WBGene00001915", "Q27876", "WBGene00001922", "Q27894", "WBGene00001878", "P62784", "WBGene00001875", "WBGene00000223" ] }, "reaction_10548040": { "compartment": "compartment_7660", "id": "reaction_10548040", "reactome": "R-CEL-3769447", "name": "HDAC1:2-containing complex deacetylate histones", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10547965" ], "products": [ "species_10547971", "species_5566518" ], "modifiers": [ [ "species_10548037", "catalyst" ] ], "additional_components": [ "P62784", "WBGene00001875", "P90916", "WBGene00003036", "G5EBZ4", "WBGene00002637", "Q22516", "WBGene00000482", "G5ECR1", "WBGene00023409", "O61907", "WBGene00003025", "P90917", "WBGene00004312", "G5ECH0", "WBGene00001836", "Q09440", "WBGene00001835", "Q9NF71", "WBGene00013632", "O18691", "WBGene00013632", "Q18919", "WBGene00005006", "Q95Y41", "WBGene00022278", "A5JYT9", "WBGene00009508", "Q11107", "WBGene00003002" ] }, "reaction_10548187": { "compartment": "compartment_7660", "id": "reaction_10548187", "reactome": "R-CEL-3782655", "name": "HDAC10 deacetylates histone", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10547965" ], "products": [ "species_10547971", "species_5566518" ], "modifiers": [ [ "species_10548184", "catalyst" ] ], "additional_components": [ "P62784", "WBGene00001875", "WBGene00001838" ] }, "reaction_10520785": { "compartment": "compartment_17951", "id": "reaction_10520785", "reactome": "R-CEL-390284", "name": "propionyl-CoA + carnitine => propionylcarnitine + CoASH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_192314", "species_390294" ], "products": [ "species_193514", "species_390274" ], "modifiers": [ [ "species_10520782", "catalyst" ] ], "additional_components": [ "WBGene00007175" ] }, "reaction_10520754": { "compartment": "compartment_17951", "id": "reaction_10520754", "reactome": "R-CEL-389986", "name": "trans-2,3-dehydropristanoyl-CoA + H2O => 3-hydroxypristanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_141343", "species_389894" ], "products": [ "species_389982" ], "modifiers": [ [ "species_10513270", "catalyst" ] ], "additional_components": [ "Q19058", "WBGene00017123" ] }, "reaction_10520739": { "compartment": "compartment_17951", "id": "reaction_10520739", "reactome": "R-CEL-389889", "name": "ACOX2:FAD, ACOXL:FAD oxidise (2S)-pristanoyl-CoA to trans-2,3-dehydropristanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113535", "species_389893" ], "products": [ "species_113575", "species_389894" ], "modifiers": [ [ "species_10513307", "catalyst" ] ], "additional_components": [ "species_113596", "P34355", "WBGene00008167", "O62138", "WBGene00008566", "Q93839", "WBGene00010336", "O62139", "WBGene00008567", "O62140", "WBGene00008564", "O62137", "WBGene00008565" ] }, "reaction_10520787": { "compartment": "compartment_17951", "id": "reaction_10520787", "reactome": "R-CEL-390291", "name": "acetyl-CoA + carnitine => acetylcarnitine + CoASH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_353123", "species_390294" ], "products": [ "species_390287", "species_193514" ], "modifiers": [ [ "species_10520782", "catalyst" ] ], "additional_components": [ "WBGene00007175" ] }, "reaction_10520756": { "compartment": "compartment_17951", "id": "reaction_10520756", "reactome": "R-CEL-389995", "name": "3-hydroxypristanoyl-CoA + NAD+ => 3-ketoxypristanoyl-CoA + NADH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_389982", "species_192307" ], "products": [ "species_193465", "species_389996", "species_192305" ], "modifiers": [ [ "species_10513270", "catalyst" ] ], "additional_components": [ "Q19058", "WBGene00017123" ] }, "reaction_10520790": { "compartment": "compartment_17951", "id": "reaction_10520790", "reactome": "R-CEL-390304", "name": "acetyl-CoA + H2O => acetate + CoASH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_141343", "species_353123" ], "products": [ "species_193514", "species_390305" ], "modifiers": [ [ "species_10513389", "catalyst" ] ], "additional_components": [ "WBGene00015887" ] }, "reaction_10520777": { "compartment": "compartment_17951", "id": "reaction_10520777", "reactome": "R-CEL-390281", "name": "4,8-dimethylnonanoyl-CoA + carnitine => 4,8-dimethylnonanoylcarnitine + CoASH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_390271", "species_390294" ], "products": [ "species_193514", "species_390290" ], "modifiers": [ [ "species_10520774", "catalyst" ] ], "additional_components": [ "WBGene00011850" ] }, "reaction_10520749": { "compartment": "compartment_17951", "id": "reaction_10520749", "reactome": "R-CEL-389891", "name": "(2S)-pristanoyl-CoA + O2 => trans-2,3-dehydropristanoyl-CoA + H2O2 (ACOX3)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113535", "species_389893" ], "products": [ "species_113575", "species_389894" ], "modifiers": [ [ "species_10520746", "catalyst" ] ], "additional_components": [ "species_113596", "Q20992", "WBGene00019060" ] }, "reaction_10520751": { "compartment": "compartment_17951", "id": "reaction_10520751", "reactome": "R-CEL-389897", "name": "Isomerization of (2R)-pristanoyl-CoA to (2S)-pristanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_389569" ], "products": [ "species_389893" ], "modifiers": [ [ "species_10513241", "catalyst" ] ], "additional_components": [ "WBGene00016034" ] }, "reaction_10513025": { "compartment": "compartment_70101", "id": "reaction_10513025", "reactome": "R-CEL-191323", "name": "HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191293", "species_76183" ], "products": [ "species_29356", "species_191374", "species_76194" ], "modifiers": [ [ "species_10513022", "catalyst" ] ], "additional_components": [ "WBGene00017769" ] }, "reaction_10513507": { "compartment": "compartment_70101", "id": "reaction_10513507", "reactome": "R-CEL-194642", "name": "4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_194735", "species_29360" ], "products": [ "species_70106", "species_113528", "species_194667", "species_73473" ], "modifiers": [ [ "species_10513504", "catalyst" ] ], "additional_components": [ "WBGene00012394" ] }, "reaction_10513509": { "compartment": "compartment_70101", "id": "reaction_10513509", "reactome": "R-CEL-194718", "name": "4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_194657", "species_29360" ], "products": [ "species_70106", "species_113528", "species_194661", "species_73473" ], "modifiers": [ [ "species_10513504", "catalyst" ] ], "additional_components": [ "WBGene00012394" ] }, "reaction_10513665": { "compartment": "compartment_70101", "id": "reaction_10513665", "reactome": "R-CEL-196402", "name": "Cholesta-5,7,24-trien-3beta-ol is reduced to desmosterol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_195655", "species_29364" ], "products": [ "species_29366", "species_196420" ], "modifiers": [ [ "species_10513662", "catalyst" ] ], "additional_components": [ "WBGene00007126" ] }, "reaction_10513673": { "compartment": "compartment_70101", "id": "reaction_10513673", "reactome": "R-CEL-196417", "name": "Reduction of desmosterol to cholesterol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_196420", "species_29364" ], "products": [ "species_193384", "species_29366" ], "modifiers": [ [ "species_10513670", "catalyst" ] ], "additional_components": [ "WBGene00018718" ] }, "reaction_10513065": { "compartment": "compartment_70101", "id": "reaction_10513065", "reactome": "R-CEL-191414", "name": "MVD decarboxylates MVA5PP to IPPP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_191403" ], "products": [ "species_29372", "species_29370", "species_113528", "species_191362" ], "modifiers": [ [ "species_10513062", "catalyst" ] ], "additional_components": [ "Q9U294", "WBGene00012984" ] }, "reaction_10513035": { "compartment": "compartment_70101", "id": "reaction_10513035", "reactome": "R-CEL-191352", "name": "HMGCR dimer reduces bHMG-CoA to MVA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191374", "species_70106", "species_29364" ], "products": [ "species_29366", "species_76194", "species_191424" ], "modifiers": [ [ "species_10513032", "catalyst" ] ], "additional_components": [ "Q19207", "WBGene00017268" ] }, "reaction_10563129": { "compartment": "compartment_12045", "id": "reaction_10563129", "reactome": "R-CEL-6807055", "name": "DHCR7 reduces 7-dehydroCHOL to CHOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_6807057", "species_29364" ], "products": [ "species_193384", "species_29366" ], "modifiers": [ [ "species_10513662", "catalyst" ] ], "additional_components": [ "WBGene00007126" ] }, "reaction_10563131": { "compartment": "compartment_12045", "id": "reaction_10563131", "reactome": "R-CEL-6807064", "name": "DHCR24 reduces ZYMOL to ZYMSTNL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_194691" ], "products": [ "species_6807048", "species_29366" ], "modifiers": [ [ "species_10513670", "catalyst" ] ], "additional_components": [ "WBGene00018718" ] }, "reaction_10513073": { "compartment": "compartment_70101", "id": "reaction_10513073", "reactome": "R-CEL-191422", "name": "Mevalonate-5-phosphate is further phosphorylated.", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_191296" ], "products": [ "species_29370", "species_191403" ], "modifiers": [ [ "species_10513070", "catalyst" ] ], "additional_components": [ "WBGene00009335" ] }, "reaction_10513045": { "compartment": "compartment_70101", "id": "reaction_10513045", "reactome": "R-CEL-191380", "name": "Mevalonate is phosphorylated to mevalonate-5-phosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_191424" ], "products": [ "species_29370", "species_191296" ], "modifiers": [ [ "species_10513042", "catalyst" ] ], "additional_components": [ "Q65XX9", "WBGene00021534" ] }, "reaction_10569175": { "compartment": "compartment_70101", "id": "reaction_10569175", "reactome": "R-CEL-8952137", "name": "Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_191265" ], "products": [ "species_8952135", "species_29372" ], "modifiers": [ [ "species_10569172", "catalyst" ] ], "additional_components": [ "WBGene00020486" ] }, "reaction_10513017": { "compartment": "compartment_70101", "id": "reaction_10513017", "reactome": "R-CEL-191303", "name": "Another isopentenyl pyrophosphate is added to geranyl pyrophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191409", "species_191362" ], "products": [ "species_111294", "species_191385" ], "modifiers": [ [ "species_10513014", "catalyst" ] ], "additional_components": [ "O62336", "WBGene00011058", "species_114632" ] }, "reaction_10551001": { "compartment": "compartment_17957", "id": "reaction_10551001", "reactome": "R-CEL-5250531", "name": "ARV1 transports CHOL from ER membrane to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193384" ], "products": [ "species_171095" ], "modifiers": [ [ "species_10550998", "catalyst" ] ], "additional_components": [ "WBGene00011040" ] }, "reaction_10513020": { "compartment": "compartment_70101", "id": "reaction_10513020", "reactome": "R-CEL-191322", "name": "Addition of isopentenyl pyrophosphate to DMAPP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191324", "species_191362" ], "products": [ "species_111294", "species_191409" ], "modifiers": [ [ "species_10513014", "catalyst" ] ], "additional_components": [ "O62336", "WBGene00011058", "species_114632" ] }, "reaction_10513055": { "compartment": "compartment_70101", "id": "reaction_10513055", "reactome": "R-CEL-191382", "name": "Isopentenyl pyrophosphate rearranges to dimethylallyl pyrophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191362" ], "products": [ "species_191324" ], "modifiers": [ [ "species_10513052", "catalyst" ] ], "additional_components": [ "species_114632", "G5EFQ1", "WBGene00019460" ] }, "reaction_10546084": { "compartment": "compartment_7660", "id": "reaction_10546084", "reactome": "R-CEL-2993780", "name": "Transfer of SUMO1 from E1 to UBE2I (UBC9)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546073", "species_10546009" ], "products": [ "species_10546081", "species_10545999" ], "modifiers": [ [ "species_10545999", "catalyst" ] ], "additional_components": [ "WBGene00006706", "Q9NAN1", "WBGene00006700", "P55853", "WBGene00004888", "Q17820", "WBGene00000142", "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "Q17820", "WBGene00000142", "Q9NAN1", "WBGene00006700", "Q17820", "WBGene00000142", "Q9NAN1", "WBGene00006700" ] }, "reaction_10563041": { "compartment": "compartment_984", "id": "reaction_10563041", "reactome": "R-CEL-6804099", "name": "HMGB1 binds LTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10563037", "species_181015" ], "products": [ "species_10563039" ], "modifiers": [], "additional_components": [ "G5EFV4", "WBGene00001971", "Q09390", "WBGene00001972", "species_181015", "G5EFV4", "WBGene00001971", "Q09390", "WBGene00001972" ] }, "reaction_10563090": { "compartment": "compartment_984", "id": "reaction_10563090", "reactome": "R-CEL-6805981", "name": "HMGB1 release from cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10517878" ], "products": [ "species_10563037" ], "modifiers": [], "additional_components": [ "Q09390", "WBGene00001972", "G5EFV4", "WBGene00001971", "G5EFV4", "WBGene00001971", "Q09390", "WBGene00001972" ] }, "reaction_10563045": { "compartment": "compartment_984", "id": "reaction_10563045", "reactome": "R-CEL-6804100", "name": "HMGB1 binds LPS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10563037", "species_166005" ], "products": [ "species_10563043" ], "modifiers": [], "additional_components": [ "G5EFV4", "WBGene00001971", "Q09390", "WBGene00001972", "species_166005", "G5EFV4", "WBGene00001971", "Q09390", "WBGene00001972" ] }, "reaction_10566733": { "compartment": "compartment_984", "id": "reaction_10566733", "reactome": "R-CEL-8869683", "name": "oxPL binds LBP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10510717", "species_2186967" ], "products": [ "species_10566731" ], "modifiers": [], "additional_components": [ "Q20380", "WBGene00022627", "Q17654", "WBGene00022627", "H9G2Z8", "WBGene00022627", "Q23365", "WBGene00022627", "Q17738", "WBGene00022627", "O17768", "WBGene00022627", "Q93796", "WBGene00003812", "Q18869", "WBGene00022627", "Q10011", "WBGene00020563", "A8WFJ7", "WBGene00022627", "species_2186967", "Q20380", "WBGene00022627", "Q17654", "WBGene00022627", "H9G2Z8", "WBGene00022627", "Q23365", "WBGene00022627", "Q17738", "WBGene00022627", "O17768", "WBGene00022627", "Q93796", "WBGene00003812", "Q18869", "WBGene00022627", "Q10011", "WBGene00020563", "A8WFJ7", "WBGene00022627" ] }, "reaction_10510723": { "compartment": "compartment_984", "id": "reaction_10510723", "reactome": "R-CEL-166015", "name": "Association of LBP with LPS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10510717", "species_166005" ], "products": [ "species_10510719" ], "modifiers": [ [ "species_10510721", "inhibitor" ] ], "additional_components": [ "Q20380", "WBGene00022627", "Q17654", "WBGene00022627", "H9G2Z8", "WBGene00022627", "Q23365", "WBGene00022627", "Q17738", "WBGene00022627", "O17768", "WBGene00022627", "Q93796", "WBGene00003812", "Q18869", "WBGene00022627", "Q10011", "WBGene00020563", "A8WFJ7", "WBGene00022627", "species_166005", "Q20380", "WBGene00022627", "Q17654", "WBGene00022627", "H9G2Z8", "WBGene00022627", "Q23365", "WBGene00022627", "Q17738", "WBGene00022627", "O17768", "WBGene00022627", "Q93796", "WBGene00003812", "Q18869", "WBGene00022627", "Q10011", "WBGene00020563", "A8WFJ7", "WBGene00022627", "WBGene00020563" ] }, "reaction_10569028": { "compartment": "compartment_70101", "id": "reaction_10569028", "reactome": "R-CEL-8950778", "name": "p-Y693-STAT4 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10568972" ], "products": [ "species_10568974" ], "modifiers": [], "additional_components": [ "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111" ] }, "reaction_10568984": { "compartment": "compartment_70101", "id": "reaction_10568984", "reactome": "R-CEL-8950181", "name": "Y693-STAT4 dimer translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10568974" ], "products": [ "species_10568982" ], "modifiers": [], "additional_components": [ "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111" ] }, "reaction_10569026": { "compartment": "compartment_876", "id": "reaction_10569026", "reactome": "R-CEL-8950766", "name": "IL27RA dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10569022" ], "products": [ "species_10569024" ], "modifiers": [], "additional_components": [ "WBGene00002915", "Q9UB28", "WBGene00002915" ] }, "reaction_10569032": { "compartment": "compartment_70101", "id": "reaction_10569032", "reactome": "R-CEL-8950782", "name": "p-STAT1 binds p-STAT3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10531883", "species_10528453" ], "products": [ "species_10531889" ], "modifiers": [], "additional_components": [ "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111" ] }, "reaction_10569020": { "compartment": "compartment_70101", "id": "reaction_10569020", "reactome": "R-CEL-8950733", "name": "p-Y701-STAT1:p-Y705-STAT3 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10531889" ], "products": [ "species_10531901" ], "modifiers": [], "additional_components": [ "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111" ] }, "reaction_10568990": { "compartment": "compartment_17957", "id": "reaction_10568990", "reactome": "R-CEL-8950387", "name": "CANX binds EBI3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10568986", "species_10527249" ], "products": [ "species_10568988" ], "modifiers": [], "additional_components": [ "WBGene00002915", "WBGene00000567", "P34652", "WBGene00000567", "Q9UB28", "WBGene00002915" ] }, "reaction_10569012": { "compartment": "compartment_70101", "id": "reaction_10569012", "reactome": "R-CEL-8950522", "name": "p-STAT1:p-STAT4 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10569008" ], "products": [ "species_10569010" ], "modifiers": [], "additional_components": [ "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111" ] }, "reaction_10521955": { "compartment": "compartment_70101", "id": "reaction_10521955", "reactome": "R-CEL-419049", "name": "ROCK activation by RHO", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10521949", "species_10509488" ], "products": [ "species_10521951" ], "modifiers": [ [ "species_10521953", "inhibitor" ] ], "additional_components": [ "P92199", "WBGene00002694", "Q21025", "WBGene00019087", "Q9XVH4", "WBGene00019087", "Q22038", "WBGene00004357", "species_29438", "Q22038", "WBGene00004357", "species_29438", "P92199", "WBGene00002694", "Q21025", "WBGene00019087", "Q9XVH4", "WBGene00019087", "P92199", "WBGene00002694", "Q21025", "WBGene00019087", "Q9XVH4", "WBGene00019087" ] }, "reaction_10573094": { "compartment": "compartment_70101", "id": "reaction_10573094", "reactome": "R-CEL-9680443", "name": "ROCK1,2 bind ROCKi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9686558", "species_10521949" ], "products": [ "species_10521953" ], "modifiers": [], "additional_components": [ "P92199", "WBGene00002694", "Q21025", "WBGene00019087", "Q9XVH4", "WBGene00019087", "P92199", "WBGene00002694", "Q21025", "WBGene00019087", "Q9XVH4", "WBGene00019087" ] }, "reaction_10514868": { "compartment": "compartment_70101", "id": "reaction_10514868", "reactome": "R-CEL-201608", "name": "Caspase-mediated cleavage of alpha adducin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10514862" ], "products": [ "species_10514866", "species_10514864" ], "modifiers": [ [ "species_10509422", "catalyst" ] ], "additional_components": [ "WBGene00000073", "WBGene00000073", "WBGene00000073", "P42573", "WBGene00000417" ] }, "reaction_10515348": { "compartment": "compartment_70101", "id": "reaction_10515348", "reactome": "R-CEL-202966", "name": "Caspase mediated cleavage of HIP-55", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10515342" ], "products": [ "species_10515346", "species_10515344" ], "modifiers": [ [ "species_10509422", "catalyst" ] ], "additional_components": [ "WBGene00010664", "WBGene00010664", "WBGene00010664", "P42573", "WBGene00000417" ] }, "reaction_10515359": { "compartment": "compartment_70101", "id": "reaction_10515359", "reactome": "R-CEL-202967", "name": "Caspase mediated cleavage of alpha-II-Fodrin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10515353" ], "products": [ "species_10515357", "species_10515355" ], "modifiers": [ [ "species_10509422", "catalyst" ] ], "additional_components": [ "WBGene00004951", "WBGene00004951", "WBGene00004951", "P42573", "WBGene00000417" ] }, "reaction_10572369": { "compartment": "compartment_161320", "id": "reaction_10572369", "reactome": "R-CEL-9638076", "name": "HEXB cleaves the terminal GalNAc from small HA fragments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2162223", "species_1605715" ], "products": [ "species_1678743", "species_2162224" ], "modifiers": [ [ "species_10536355", "catalyst" ] ], "additional_components": [ "Q22492", "WBGene00020509" ] }, "reaction_10543041": { "compartment": "compartment_161320", "id": "reaction_10543041", "reactome": "R-CEL-2162225", "name": "HEXA cleaves the terminal GalNAc from small HA fragments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2162223", "species_1605715" ], "products": [ "species_1678743", "species_2162224" ], "modifiers": [ [ "species_10536342", "catalyst" ] ], "additional_components": [ "Q22492", "WBGene00020509" ] }, "reaction_10543043": { "compartment": "compartment_161320", "id": "reaction_10543043", "reactome": "R-CEL-2162226", "name": "GUSB tetramer hydrolyses GlcA-1,3-GlcNAc", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2162224" ], "products": [ "species_1678743", "species_1678868" ], "modifiers": [ [ "species_10537432", "catalyst" ] ], "additional_components": [ "Q95Q32", "WBGene00013693" ] }, "reaction_10543045": { "compartment": "compartment_161320", "id": "reaction_10543045", "reactome": "R-CEL-2162227", "name": "GUSB tetramer hydrolyses (HA)2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2160866" ], "products": [ "species_2162223", "species_1678868" ], "modifiers": [ [ "species_10537432", "catalyst" ] ], "additional_components": [ "species_2162224", "Q95Q32", "WBGene00013693" ] }, "reaction_10542936": { "compartment": "compartment_161320", "id": "reaction_10542936", "reactome": "R-CEL-2160874", "name": "HYAL1 hydrolyses (HA)50", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2160864" ], "products": [ "species_2160866" ], "modifiers": [ [ "species_10537452", "catalyst" ] ], "additional_components": [ "species_2162224", "species_2162224", "WBGene00011923" ] }, "reaction_10542957": { "compartment": "compartment_876", "id": "reaction_10542957", "reactome": "R-CEL-2160892", "name": "Hyaluronidase 2 (HYAL2) hydrolyses HA into 20kDa fragments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10542954" ], "products": [ "species_2160894", "species_10542954" ], "modifiers": [ [ "species_10542954", "catalyst" ] ], "additional_components": [ "species_74016", "Q23643", "WBGene00014109", "P35449", "WBGene00003736", "G5EDU2", "WBGene00003732", "Q8T5S1", "WBGene00003730", "H2L039", "WBGene00003734", "O16452", "WBGene00003731", "species_2162224", "G5ECE8", "WBGene00011923", "species_2162224", "species_74016", "Q23643", "WBGene00014109", "P35449", "WBGene00003736", "G5EDU2", "WBGene00003732", "Q8T5S1", "WBGene00003730", "H2L039", "WBGene00003734", "O16452", "WBGene00003731", "species_2162224", "G5ECE8", "WBGene00011923", "species_74016", "Q23643", "WBGene00014109", "P35449", "WBGene00003736", "G5EDU2", "WBGene00003732", "Q8T5S1", "WBGene00003730", "H2L039", "WBGene00003734", "O16452", "WBGene00003731", "species_2162224", "G5ECE8", "WBGene00011923" ] }, "reaction_10502580": { "compartment": "compartment_7660", "id": "reaction_10502580", "reactome": "R-CEL-68950", "name": "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30187", "species_30185", "species_10502151", "species_29892", "species_29604" ], "products": [ "species_10502577" ], "modifiers": [ [ "species_10502123", "catalyst" ] ], "additional_components": [ "C7IVS4", "WBGene00012936", "P34471", "WBGene00004180", "O02334", "WBGene00004181", "Q21625", "WBGene00001002", "C7IVS4", "WBGene00012936", "P34471", "WBGene00004180", "O02334", "WBGene00004181", "Q21625", "WBGene00001002", "C7IVS4", "WBGene00012936", "P34471", "WBGene00004180", "O02334", "WBGene00004181", "Q21625", "WBGene00001002" ] }, "reaction_10502154": { "compartment": "compartment_7660", "id": "reaction_10502154", "reactome": "R-CEL-68913", "name": "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502149", "species_30595" ], "products": [ "species_10502151", "species_10502145" ], "modifiers": [ [ "species_10502149", "catalyst" ] ], "additional_components": [ "O62218", "WBGene00009368", "Q19196", "WBGene00017237", "Q22798", "WBGene00020823", "Q9NAC5", "WBGene00013150", "C7IVS4", "WBGene00012936", "P34471", "WBGene00004180", "O02334", "WBGene00004181", "Q21625", "WBGene00001002", "species_110614", "species_29358", "species_29494", "species_29438", "C7IVS4", "WBGene00012936", "P34471", "WBGene00004180", "O02334", "WBGene00004181", "Q21625", "WBGene00001002", "O62218", "WBGene00009368", "Q19196", "WBGene00017237", "Q22798", "WBGene00020823", "Q9NAC5", "WBGene00013150", "O62218", "WBGene00009368", "Q19196", "WBGene00017237", "Q22798", "WBGene00020823", "Q9NAC5", "WBGene00013150", "C7IVS4", "WBGene00012936", "P34471", "WBGene00004180", "O02334", "WBGene00004181", "Q21625", "WBGene00001002" ] }, "reaction_10502343": { "compartment": "compartment_7660", "id": "reaction_10502343", "reactome": "R-CEL-68946", "name": "Phosphorylated Orc1 is ubiquitinated while still associated with chromatin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502318", "species_10502250" ], "products": [ "species_10502321" ], "modifiers": [ [ "species_10502340", "catalyst" ] ], "additional_components": [ "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "WBGene00012650", "WBGene00012650", "Q23457", "WBGene00004320", "G5ECU1", "WBGene00004807", "Q17389", "WBGene00000836" ] }, "reaction_10502281": { "compartment": "compartment_7660", "id": "reaction_10502281", "reactome": "R-CEL-68944", "name": "Orc1 is phosphorylated by cyclin A/CDK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10502240" ], "products": [ "species_113582", "species_10502252", "species_10502250" ], "modifiers": [ [ "species_10502278", "catalyst" ] ], "additional_components": [ "O16297", "WBGene00003159", "Q95XQ8", "WBGene00003156", "Q9XXI9", "WBGene00003154", "Q21902", "WBGene00003157", "P34647", "WBGene00003158", "Q9XVR7", "WBGene00003155", "Q9XX16", "WBGene00012651", "Q23249", "WBGene00013857", "Q9XX17", "WBGene00012650", "Q21037", "WBGene00003882", "P91155", "WBGene00000382", "Q86S68", "WBGene00000413", "Q9XX16", "WBGene00012651", "Q86S68", "WBGene00000413", "P91155", "WBGene00000382", "Q23249", "WBGene00013857", "O16297", "WBGene00003159", "Q95XQ8", "WBGene00003156", "Q9XXI9", "WBGene00003154", "Q21902", "WBGene00003157", "P34647", "WBGene00003158", "Q9XVR7", "WBGene00003155", "Q21037", "WBGene00003882", "WBGene00012650", "O61847", "WBGene00019362" ] }, "reaction_10502347": { "compartment": "compartment_7660", "id": "reaction_10502347", "reactome": "R-CEL-68947", "name": "Ubiquitinated Orc1 enters the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502321" ], "products": [ "species_10502345" ], "modifiers": [], "additional_components": [ "WBGene00012650", "WBGene00012650" ] }, "reaction_10502575": { "compartment": "compartment_70101", "id": "reaction_10502575", "reactome": "R-CEL-68948", "name": "Ubiquitinated Orc1 is degraded by the proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502345" ], "products": [ "species_10502375" ], "modifiers": [ [ "species_10502572", "catalyst" ] ], "additional_components": [ "WBGene00012650", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "P91477", "WBGene00003950", "Q95PZ7", "WBGene00013435", "Q18115", "WBGene00004459", "O62102", "WBGene00003948", "O17071", "WBGene00004504", "Q10920", "WBGene00016623", "P34286", "WBGene00003952", "Q9XTT9", "WBGene00004506", "Q23449", "WBGene00004468", "Q95005", "WBGene00003925", "P46502", "WBGene00004503", "O61792", "WBGene00004464", "O17586", "WBGene00003922", "O76371", "WBGene00004505", "Q20585", "WBGene00004463", "Q95008", "WBGene00003926", "Q18787", "WBGene00004501", "Q20058", "WBGene00009445", "Q9N599", "WBGene00003924", "O16368", "WBGene00004502", "O61742", "WBGene00004466", "Q09583", "WBGene00003928", "Q966I8", "WBGene00003947", "Q04908", "WBGene00004460", "Q9XUV0", "WBGene00003951", "Q27488", "WBGene00003923", "Q9GZH5", "WBGene00004458", "O44156", "WBGene00003927", "Q22253", "WBGene00004465", "O76577", "WBGene00004467", "P90868", "WBGene00003953", "Q19324", "WBGene00004461", "Q17971", "WBGene00007588", "Q23237", "WBGene00003949", "Q20938", "WBGene00004462" ] }, "reaction_10502611": { "compartment": "compartment_70101", "id": "reaction_10502611", "reactome": "R-CEL-69016", "name": "Ubiquitinated Cdc6 is degraded by the proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502609" ], "products": [ "species_10502375" ], "modifiers": [ [ "species_10502572", "catalyst" ] ], "additional_components": [ "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "P91155", "WBGene00000382", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "P91477", "WBGene00003950", "Q95PZ7", "WBGene00013435", "Q18115", "WBGene00004459", "O62102", "WBGene00003948", "O17071", "WBGene00004504", "Q10920", "WBGene00016623", "P34286", "WBGene00003952", "Q9XTT9", "WBGene00004506", "Q23449", "WBGene00004468", "Q95005", "WBGene00003925", "P46502", "WBGene00004503", "O61792", "WBGene00004464", "O17586", "WBGene00003922", "O76371", "WBGene00004505", "Q20585", "WBGene00004463", "Q95008", "WBGene00003926", "Q18787", "WBGene00004501", "Q20058", "WBGene00009445", "Q9N599", "WBGene00003924", "O16368", "WBGene00004502", "O61742", "WBGene00004466", "Q09583", "WBGene00003928", "Q966I8", "WBGene00003947", "Q04908", "WBGene00004460", "Q9XUV0", "WBGene00003951", "Q27488", "WBGene00003923", "Q9GZH5", "WBGene00004458", "O44156", "WBGene00003927", "Q22253", "WBGene00004465", "O76577", "WBGene00004467", "P90868", "WBGene00003953", "Q19324", "WBGene00004461", "Q17971", "WBGene00007588", "Q23237", "WBGene00003949", "Q20938", "WBGene00004462" ] }, "reaction_10502601": { "compartment": "compartment_7660", "id": "reaction_10502601", "reactome": "R-CEL-69005", "name": "Cdc6 protein is phosphorylated by CDK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10502084" ], "products": [ "species_113582", "species_10502587" ], "modifiers": [ [ "species_10502598", "catalyst" ] ], "additional_components": [ "WBGene00000382", "WBGene00000382", "O01501", "WBGene00000871", "O61847", "WBGene00019362" ] }, "reaction_10502605": { "compartment": "compartment_7660", "id": "reaction_10502605", "reactome": "R-CEL-69006", "name": "Phosphorylated Cdc6 is exported from the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502587" ], "products": [ "species_10502603" ], "modifiers": [], "additional_components": [ "WBGene00000382", "WBGene00000382" ] }, "reaction_10502615": { "compartment": "compartment_7660", "id": "reaction_10502615", "reactome": "R-CEL-69019", "name": "Mcm4,6,7 trimer forms and associates with the replication fork", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502216" ], "products": [ "species_10502189", "species_10502199", "species_10502214", "species_10502613" ], "modifiers": [], "additional_components": [ "O16297", "WBGene00003159", "Q95XQ8", "WBGene00003156", "Q9XXI9", "WBGene00003154", "Q21902", "WBGene00003157", "P34647", "WBGene00003158", "Q9XVR7", "WBGene00003155", "WBGene00003155", "WBGene00003157", "WBGene00003154", "O16297", "WBGene00003159", "Q95XQ8", "WBGene00003156", "P34647", "WBGene00003158" ] }, "reaction_10512052": { "compartment": "compartment_7660", "id": "reaction_10512052", "reactome": "R-CEL-176956", "name": "Formation of GINS complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10512043", "species_10512038", "species_10512033", "species_10512048" ], "products": [ "species_10512050" ], "modifiers": [], "additional_components": [ "WBGene00022043", "WBGene00009287", "WBGene00011275", "WBGene00013768", "Q9U2W9", "WBGene00013768", "Q22019", "WBGene00011275", "O62193", "WBGene00009287", "Q9BL54", "WBGene00022043" ] }, "reaction_10502657": { "compartment": "compartment_7660", "id": "reaction_10502657", "reactome": "R-CEL-69063", "name": "Loading of PCNA - Sliding Clamp Formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10502653", "species_10502644" ], "products": [ "species_113582", "species_10502655" ], "modifiers": [], "additional_components": [ "O02115", "WBGene00003955", "C7IVS4", "WBGene00012936", "P34471", "WBGene00004180", "O02334", "WBGene00004181", "Q21625", "WBGene00001002", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "C7IVS4", "WBGene00012936", "P34471", "WBGene00004180", "O02334", "WBGene00004181", "Q21625", "WBGene00001002", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "O02115", "WBGene00003955" ] }, "reaction_10502661": { "compartment": "compartment_7660", "id": "reaction_10502661", "reactome": "R-CEL-69068", "name": "RFC dissociates after sliding clamp formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502655" ], "products": [ "species_10502659", "species_10502642" ], "modifiers": [], "additional_components": [ "C7IVS4", "WBGene00012936", "P34471", "WBGene00004180", "O02334", "WBGene00004181", "Q21625", "WBGene00001002", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "O02115", "WBGene00003955", "C7IVS4", "WBGene00012936", "P34471", "WBGene00004180", "O02334", "WBGene00004181", "Q21625", "WBGene00001002", "O02115", "WBGene00003955", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409" ] }, "reaction_10502646": { "compartment": "compartment_7660", "id": "reaction_10502646", "reactome": "R-CEL-69053", "name": "RFC binding displaces Pol Alpha", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502642", "species_10502577" ], "products": [ "species_10502644" ], "modifiers": [], "additional_components": [ "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "C7IVS4", "WBGene00012936", "P34471", "WBGene00004180", "O02334", "WBGene00004181", "Q21625", "WBGene00001002", "C7IVS4", "WBGene00012936", "P34471", "WBGene00004180", "O02334", "WBGene00004181", "Q21625", "WBGene00001002", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409" ] }, "reaction_10502684": { "compartment": "compartment_7660", "id": "reaction_10502684", "reactome": "R-CEL-69074", "name": "Formation of Processive Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502680", "species_10502659" ], "products": [ "species_10502682" ], "modifiers": [], "additional_components": [ "P90829", "WBGene00008645", "Q19366", "WBGene00008722", "Q21730", "WBGene00011016", "C7IVS4", "WBGene00012936", "P34471", "WBGene00004180", "O02334", "WBGene00004181", "Q21625", "WBGene00001002", "O02115", "WBGene00003955", "C7IVS4", "WBGene00012936", "P34471", "WBGene00004180", "O02334", "WBGene00004181", "Q21625", "WBGene00001002", "O02115", "WBGene00003955", "P90829", "WBGene00008645", "Q19366", "WBGene00008722", "Q21730", "WBGene00011016" ] }, "reaction_10502727": { "compartment": "compartment_7660", "id": "reaction_10502727", "reactome": "R-CEL-69152", "name": "Removal of remaining Flap", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502717" ], "products": [ "species_10502719" ], "modifiers": [ [ "species_10502724", "catalyst" ] ], "additional_components": [ "C7IVS4", "WBGene00012936", "P34471", "WBGene00004180", "O02334", "WBGene00004181", "Q21625", "WBGene00001002", "O02115", "WBGene00003955", "P90829", "WBGene00008645", "Q19366", "WBGene00008722", "Q21730", "WBGene00011016", "C7IVS4", "WBGene00012936", "P34471", "WBGene00004180", "O02334", "WBGene00004181", "Q21625", "WBGene00001002", "O02115", "WBGene00003955", "P90829", "WBGene00008645", "Q19366", "WBGene00008722", "Q21730", "WBGene00011016", "WBGene00000794" ] }, "reaction_10502715": { "compartment": "compartment_7660", "id": "reaction_10502715", "reactome": "R-CEL-69142", "name": "Recruitment of Dna2 endonuclease", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502711", "species_10502706" ], "products": [ "species_10502713" ], "modifiers": [], "additional_components": [ "WBGene00001016", "Q95Y97", "WBGene00019767", "C7IVS4", "WBGene00012936", "P34471", "WBGene00004180", "O02334", "WBGene00004181", "Q21625", "WBGene00001002", "O02115", "WBGene00003955", "P90829", "WBGene00008645", "Q19366", "WBGene00008722", "Q21730", "WBGene00011016", "Q95Y97", "WBGene00019767", "C7IVS4", "WBGene00012936", "P34471", "WBGene00004180", "O02334", "WBGene00004181", "Q21625", "WBGene00001002", "O02115", "WBGene00003955", "P90829", "WBGene00008645", "Q19366", "WBGene00008722", "Q21730", "WBGene00011016", "Q9U3F2", "WBGene00001016" ] }, "reaction_10502689": { "compartment": "compartment_7660", "id": "reaction_10502689", "reactome": "R-CEL-69116", "name": "Formation of Okazaki fragments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502682" ], "products": [ "species_10502686" ], "modifiers": [ [ "species_10502680", "catalyst" ] ], "additional_components": [ "C7IVS4", "WBGene00012936", "P34471", "WBGene00004180", "O02334", "WBGene00004181", "Q21625", "WBGene00001002", "O02115", "WBGene00003955", "P90829", "WBGene00008645", "Q19366", "WBGene00008722", "Q21730", "WBGene00011016", "C7IVS4", "WBGene00012936", "P34471", "WBGene00004180", "O02334", "WBGene00004181", "Q21625", "WBGene00001002", "O02115", "WBGene00003955", "P90829", "WBGene00008645", "Q19366", "WBGene00008722", "Q21730", "WBGene00011016", "P90829", "WBGene00008645", "Q19366", "WBGene00008722", "Q21730", "WBGene00011016" ] }, "reaction_10502693": { "compartment": "compartment_7660", "id": "reaction_10502693", "reactome": "R-CEL-69127", "name": "Formation of the Flap Intermediate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502686" ], "products": [ "species_10502691" ], "modifiers": [], "additional_components": [ "C7IVS4", "WBGene00012936", "P34471", "WBGene00004180", "O02334", "WBGene00004181", "Q21625", "WBGene00001002", "O02115", "WBGene00003955", "P90829", "WBGene00008645", "Q19366", "WBGene00008722", "Q21730", "WBGene00011016", "C7IVS4", "WBGene00012936", "P34471", "WBGene00004180", "O02334", "WBGene00004181", "Q21625", "WBGene00001002", "O02115", "WBGene00003955", "P90829", "WBGene00008645", "Q19366", "WBGene00008722", "Q21730", "WBGene00011016" ] }, "reaction_10502735": { "compartment": "compartment_7660", "id": "reaction_10502735", "reactome": "R-CEL-69173", "name": "Joining of adjacent Okazaki fragments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_68452" ], "products": [ "species_69172" ], "modifiers": [ [ "species_10502732", "catalyst" ] ], "additional_components": [ "WBGene00002985" ] }, "reaction_10544506": { "compartment": "compartment_7660", "id": "reaction_10544506", "reactome": "R-CEL-2468039", "name": "Acetylation of SMC3 subunit of chromosomal arm associated cohesin by ESCO1 or ESCO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113560", "species_10544486" ], "products": [ "species_2485002", "species_10544494" ], "modifiers": [ [ "species_10544503", "catalyst" ] ], "additional_components": [ "H2L0H5", "WBGene00019953", "B2FDA8", "WBGene00004873", "Q19325", "WBGene00004737", "Q9XUB3", "WBGene00004333", "Q19555", "WBGene00004738", "O01789", "WBGene00001860", "G5EC05", "WBGene00001352", "H2L0H5", "WBGene00019953", "Q19325", "WBGene00004737", "Q9XUB3", "WBGene00004333", "Q19555", "WBGene00004738", "B2FDA8", "WBGene00004873", "O01789", "WBGene00001860", "G5EC05", "WBGene00001352", "Q19206", "WBGene00017269" ] }, "reaction_10544558": { "compartment": "compartment_7660", "id": "reaction_10544558", "reactome": "R-CEL-2473152", "name": "Acetylation of SMC3 subunit of centromeric chromatin associated cohesin by ESCO1 or ESCO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10544554", "species_113560" ], "products": [ "species_2485002", "species_10544556" ], "modifiers": [ [ "species_10544503", "catalyst" ] ], "additional_components": [ "H2L0H5", "WBGene00019953", "B2FDA8", "WBGene00004873", "Q19325", "WBGene00004737", "Q9XUB3", "WBGene00004333", "Q19555", "WBGene00004738", "O01789", "WBGene00001860", "G5EC05", "WBGene00001352", "H2L0H5", "WBGene00019953", "Q19325", "WBGene00004737", "Q9XUB3", "WBGene00004333", "Q19555", "WBGene00004738", "B2FDA8", "WBGene00004873", "O01789", "WBGene00001860", "G5EC05", "WBGene00001352", "Q19206", "WBGene00017269" ] }, "reaction_10511601": { "compartment": "compartment_70101", "id": "reaction_10511601", "reactome": "R-CEL-174054", "name": "Formation of Cyclin A:Cdk2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10511204", "species_10502737" ], "products": [ "species_10511599" ], "modifiers": [], "additional_components": [ "WBGene00019362", "O61847", "WBGene00019362" ] }, "reaction_10513907": { "compartment": "compartment_70101", "id": "reaction_10513907", "reactome": "R-CEL-198613", "name": "AKT phosphorylates p21Cip1 and p27Kip1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10512493", "species_113592" ], "products": [ "species_29370", "species_10513904" ], "modifiers": [ [ "species_10513848", "catalyst" ] ], "additional_components": [ "WBGene00000517", "WBGene00000517", "Q9XTG7", "WBGene00000103", "G4S4W1", "WBGene00016980", "Q17941", "WBGene00000102" ] }, "reaction_10512676": { "compartment": "compartment_7660", "id": "reaction_10512676", "reactome": "R-CEL-187948", "name": "Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10511632" ], "products": [ "species_113582", "species_10511634" ], "modifiers": [ [ "species_10502278", "catalyst" ] ], "additional_components": [ "WBGene00001510", "WBGene00001510", "O61847", "WBGene00019362" ] }, "reaction_10512678": { "compartment": "compartment_7660", "id": "reaction_10512678", "reactome": "R-CEL-187949", "name": "CAK-mediated phosphorylation of Cyclin A:Cdk2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10511613" ], "products": [ "species_113582", "species_10502278" ], "modifiers": [ [ "species_10506279", "catalyst" ] ], "additional_components": [ "O61847", "WBGene00019362", "O61847", "WBGene00019362", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408" ] }, "reaction_10511719": { "compartment": "compartment_13231", "id": "reaction_10511719", "reactome": "R-CEL-174273", "name": "Translocation of Cyclin A:Cdk2 complexes to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10511599" ], "products": [ "species_10511613" ], "modifiers": [], "additional_components": [ "O61847", "WBGene00019362", "O61847", "WBGene00019362" ] }, "reaction_10512609": { "compartment": "compartment_7660", "id": "reaction_10512609", "reactome": "R-CEL-187574", "name": "Degradation of ubiquitinated p27/p21 by the 26S proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10512520" ], "products": [ "species_10502318", "species_10502598", "species_10512514" ], "modifiers": [ [ "species_10512606", "catalyst" ] ], "additional_components": [ "G5ECU1", "WBGene00004807", "Q17389", "WBGene00000836", "Q17868", "WBGene00001051", "G5EEJ2", "WBGene00000517", "O01501", "WBGene00000871", "O61847", "WBGene00019362", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "O01501", "WBGene00000871", "O61847", "WBGene00019362", "G5ECU1", "WBGene00004807", "Q17389", "WBGene00000836", "Q17868", "WBGene00001051", "Q23237", "WBGene00003949", "P90868", "WBGene00003953", "Q9XUV0", "WBGene00003951", "Q966I8", "WBGene00003947", "O62102", "WBGene00003948", "O16368", "WBGene00004502", "Q18787", "WBGene00004501", "O76371", "WBGene00004505", "P46502", "WBGene00004503", "Q9XTT9", "WBGene00004506", "O17071", "WBGene00004504", "Q18115", "WBGene00004459", "Q20938", "WBGene00004462", "Q19324", "WBGene00004461", "Q22253", "WBGene00004465", "Q9GZH5", "WBGene00004458", "Q04908", "WBGene00004460", "O61742", "WBGene00004466", "O76577", "WBGene00004467", "Q20058", "WBGene00009445", "O44156", "WBGene00003927", "Q20585", "WBGene00004463", "Q27488", "WBGene00003923", "O61792", "WBGene00004464", "Q09583", "WBGene00003928", "Q23449", "WBGene00004468", "Q9N599", "WBGene00003924", "Q10920", "WBGene00016623", "Q95008", "WBGene00003926", "Q95PZ7", "WBGene00013435", "O17586", "WBGene00003922", "Q95005", "WBGene00003925", "P34286", "WBGene00003952", "P91477", "WBGene00003950" ] }, "reaction_10512612": { "compartment": "compartment_7660", "id": "reaction_10512612", "reactome": "R-CEL-187575", "name": "Ubiquitination of phospho-p27/p21", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502318", "species_10512516" ], "products": [ "species_10512520" ], "modifiers": [ [ "species_10512516", "catalyst" ] ], "additional_components": [ "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "G5ECU1", "WBGene00004807", "Q17389", "WBGene00000836", "Q17868", "WBGene00001051", "G5EEJ2", "WBGene00000517", "O01501", "WBGene00000871", "O61847", "WBGene00019362", "G5ECU1", "WBGene00004807", "Q17389", "WBGene00000836", "Q17868", "WBGene00001051", "G5EEJ2", "WBGene00000517", "O01501", "WBGene00000871", "O61847", "WBGene00019362", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "G5ECU1", "WBGene00004807", "Q17389", "WBGene00000836", "Q17868", "WBGene00001051", "G5EEJ2", "WBGene00000517", "O01501", "WBGene00000871", "O61847", "WBGene00019362" ] }, "reaction_10512518": { "compartment": "compartment_7660", "id": "reaction_10512518", "reactome": "R-CEL-187552", "name": "Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10512502", "species_10512514" ], "products": [ "species_10512516" ], "modifiers": [], "additional_components": [ "G5EEJ2", "WBGene00000517", "O01501", "WBGene00000871", "O61847", "WBGene00019362", "G5ECU1", "WBGene00004807", "Q17389", "WBGene00000836", "Q17868", "WBGene00001051", "G5ECU1", "WBGene00004807", "Q17389", "WBGene00000836", "Q17868", "WBGene00001051", "G5EEJ2", "WBGene00000517", "O01501", "WBGene00000871", "O61847", "WBGene00019362" ] }, "reaction_10512505": { "compartment": "compartment_7660", "id": "reaction_10512505", "reactome": "R-CEL-187520", "name": "Cyclin E/A:Cdk2-mediated phosphorylation of p27/p21", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10512497" ], "products": [ "species_113582", "species_10512502" ], "modifiers": [ [ "species_10512497", "catalyst" ] ], "additional_components": [ "O01501", "WBGene00000871", "O61847", "WBGene00019362", "G5EEJ2", "WBGene00000517", "G5EEJ2", "WBGene00000517", "O01501", "WBGene00000871", "O61847", "WBGene00019362", "O01501", "WBGene00000871", "O61847", "WBGene00019362", "G5EEJ2", "WBGene00000517" ] }, "reaction_10512668": { "compartment": "compartment_7660", "id": "reaction_10512668", "reactome": "R-CEL-187916", "name": "Cyclin A:Cdk2 mediated phosphorylation of p27/p21", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10512663" ], "products": [ "species_113582", "species_10512665" ], "modifiers": [ [ "species_10512663", "catalyst" ] ], "additional_components": [ "O61847", "WBGene00019362", "G5EEJ2", "WBGene00000517", "G5EEJ2", "WBGene00000517", "O61847", "WBGene00019362", "O61847", "WBGene00019362", "G5EEJ2", "WBGene00000517" ] }, "reaction_10512495": { "compartment": "compartment_13231", "id": "reaction_10512495", "reactome": "R-CEL-187506", "name": "Translocation of p27 to the nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10512493" ], "products": [ "species_10502767" ], "modifiers": [], "additional_components": [ "WBGene00000517", "WBGene00000517" ] }, "reaction_10511615": { "compartment": "compartment_7660", "id": "reaction_10511615", "reactome": "R-CEL-174110", "name": "Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10511611" ], "products": [ "species_113550", "species_10511613" ], "modifiers": [ [ "species_10502759", "catalyst" ] ], "additional_components": [ "O61847", "WBGene00019362", "O61847", "WBGene00019362", "WBGene00000389" ] }, "reaction_10511365": { "compartment": "compartment_876", "id": "reaction_10511365", "reactome": "R-CEL-170686", "name": "Adenylate cyclase increases the GTPase activity of Gi alpha", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10511333" ], "products": [ "species_29372", "species_10511351" ], "modifiers": [ [ "species_10511333", "catalyst" ] ], "additional_components": [ "Q7KPV0", "WBGene00001745", "V6CLB7", "WBGene00020997", "species_29438", "species_114632", "Q19523", "WBGene00000068", "O16880", "WBGene00000069", "G5EE33", "WBGene00000070", "Q966F9", "WBGene00000071", "O76584", "WBGene00001673", "Q9BIG5", "WBGene00001666", "Q21917", "WBGene00001669", "P91907", "WBGene00001677", "Q93743", "WBGene00001668", "Q20907", "WBGene00001670", "Q9BIG2", "WBGene00001676", "Q20910", "WBGene00001671", "species_114632", "Q19523", "WBGene00000068", "O16880", "WBGene00000069", "G5EE33", "WBGene00000070", "Q966F9", "WBGene00000071", "species_29420", "O76584", "WBGene00001673", "Q9BIG5", "WBGene00001666", "Q21917", "WBGene00001669", "P91907", "WBGene00001677", "Q93743", "WBGene00001668", "Q20907", "WBGene00001670", "Q9BIG2", "WBGene00001676", "Q20910", "WBGene00001671", "Q7KPV0", "WBGene00001745", "V6CLB7", "WBGene00020997", "Q7KPV0", "WBGene00001745", "V6CLB7", "WBGene00020997", "species_29438", "species_114632", "Q19523", "WBGene00000068", "O16880", "WBGene00000069", "G5EE33", "WBGene00000070", "Q966F9", "WBGene00000071", "O76584", "WBGene00001673", "Q9BIG5", "WBGene00001666", "Q21917", "WBGene00001669", "P91907", "WBGene00001677", "Q93743", "WBGene00001668", "Q20907", "WBGene00001670", "Q9BIG2", "WBGene00001676", "Q20910", "WBGene00001671" ] }, "reaction_10511353": { "compartment": "compartment_876", "id": "reaction_10511353", "reactome": "R-CEL-170674", "name": "Dissociation of the Gi alpha:G olf complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10511351" ], "products": [ "species_10511335", "species_10511349", "species_10508992" ], "modifiers": [], "additional_components": [ "species_114632", "Q19523", "WBGene00000068", "O16880", "WBGene00000069", "G5EE33", "WBGene00000070", "Q966F9", "WBGene00000071", "species_29420", "O76584", "WBGene00001673", "Q9BIG5", "WBGene00001666", "Q21917", "WBGene00001669", "P91907", "WBGene00001677", "Q93743", "WBGene00001668", "Q20907", "WBGene00001670", "Q9BIG2", "WBGene00001676", "Q20910", "WBGene00001671", "Q7KPV0", "WBGene00001745", "V6CLB7", "WBGene00020997", "Q7KPV0", "WBGene00001745", "V6CLB7", "WBGene00020997", "species_29420", "species_29420", "O76584", "WBGene00001673", "Q9BIG5", "WBGene00001666", "Q21917", "WBGene00001669", "P91907", "WBGene00001677", "Q93743", "WBGene00001668", "Q20907", "WBGene00001670", "Q9BIG2", "WBGene00001676", "Q20910", "WBGene00001671", "species_114632", "Q19523", "WBGene00000068", "O16880", "WBGene00000069", "G5EE33", "WBGene00000070", "Q966F9", "WBGene00000071" ] }, "reaction_10511340": { "compartment": "compartment_876", "id": "reaction_10511340", "reactome": "R-CEL-170666", "name": "Adenylate cyclase increases the GTPase activity of G alpha-olf", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10511333" ], "products": [ "species_29372", "species_10511337" ], "modifiers": [ [ "species_10511333", "catalyst" ] ], "additional_components": [ "Q7KPV0", "WBGene00001745", "V6CLB7", "WBGene00020997", "species_29438", "species_114632", "Q19523", "WBGene00000068", "O16880", "WBGene00000069", "G5EE33", "WBGene00000070", "Q966F9", "WBGene00000071", "O76584", "WBGene00001673", "Q9BIG5", "WBGene00001666", "Q21917", "WBGene00001669", "P91907", "WBGene00001677", "Q93743", "WBGene00001668", "Q20907", "WBGene00001670", "Q9BIG2", "WBGene00001676", "Q20910", "WBGene00001671", "species_114632", "Q19523", "WBGene00000068", "O16880", "WBGene00000069", "G5EE33", "WBGene00000070", "Q966F9", "WBGene00000071", "species_29438", "O76584", "WBGene00001673", "Q9BIG5", "WBGene00001666", "Q21917", "WBGene00001669", "P91907", "WBGene00001677", "Q93743", "WBGene00001668", "Q20907", "WBGene00001670", "Q9BIG2", "WBGene00001676", "Q20910", "WBGene00001671", "Q7KPV0", "WBGene00001745", "V6CLB7", "WBGene00020997", "species_29420", "Q7KPV0", "WBGene00001745", "V6CLB7", "WBGene00020997", "species_29438", "species_114632", "Q19523", "WBGene00000068", "O16880", "WBGene00000069", "G5EE33", "WBGene00000070", "Q966F9", "WBGene00000071", "O76584", "WBGene00001673", "Q9BIG5", "WBGene00001666", "Q21917", "WBGene00001669", "P91907", "WBGene00001677", "Q93743", "WBGene00001668", "Q20907", "WBGene00001670", "Q9BIG2", "WBGene00001676", "Q20910", "WBGene00001671" ] }, "reaction_10511342": { "compartment": "compartment_876", "id": "reaction_10511342", "reactome": "R-CEL-170671", "name": "G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10511331", "species_10511283" ], "products": [ "species_10511333" ], "modifiers": [], "additional_components": [ "species_114632", "Q19523", "WBGene00000068", "O16880", "WBGene00000069", "G5EE33", "WBGene00000070", "Q966F9", "WBGene00000071", "species_29438", "O76584", "WBGene00001673", "Q9BIG5", "WBGene00001666", "Q21917", "WBGene00001669", "P91907", "WBGene00001677", "Q93743", "WBGene00001668", "Q20907", "WBGene00001670", "Q9BIG2", "WBGene00001676", "Q20910", "WBGene00001671", "Q7KPV0", "WBGene00001745", "V6CLB7", "WBGene00020997", "species_29438", "Q7KPV0", "WBGene00001745", "V6CLB7", "WBGene00020997", "species_29438", "species_114632", "Q19523", "WBGene00000068", "O16880", "WBGene00000069", "G5EE33", "WBGene00000070", "Q966F9", "WBGene00000071", "O76584", "WBGene00001673", "Q9BIG5", "WBGene00001666", "Q21917", "WBGene00001669", "P91907", "WBGene00001677", "Q93743", "WBGene00001668", "Q20907", "WBGene00001670", "Q9BIG2", "WBGene00001676", "Q20910", "WBGene00001671" ] }, "reaction_10511360": { "compartment": "compartment_876", "id": "reaction_10511360", "reactome": "R-CEL-170677", "name": "The G alpha-olf:GDP:Adenylate cyclase complex dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10511358" ], "products": [ "species_10511335", "species_10508992" ], "modifiers": [], "additional_components": [ "species_114632", "Q19523", "WBGene00000068", "O16880", "WBGene00000069", "G5EE33", "WBGene00000070", "Q966F9", "WBGene00000071", "Q7KPV0", "WBGene00001745", "V6CLB7", "WBGene00020997", "species_29420", "Q7KPV0", "WBGene00001745", "V6CLB7", "WBGene00020997", "species_29420", "species_114632", "Q19523", "WBGene00000068", "O16880", "WBGene00000069", "G5EE33", "WBGene00000070", "Q966F9", "WBGene00000071" ] }, "reaction_10511347": { "compartment": "compartment_876", "id": "reaction_10511347", "reactome": "R-CEL-170672", "name": "Galpha-olf:GTP binds to adenylate cyclase and activates it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10511283", "species_10508992" ], "products": [ "species_10511344" ], "modifiers": [ [ "species_10508992", "catalyst" ] ], "additional_components": [ "Q7KPV0", "WBGene00001745", "V6CLB7", "WBGene00020997", "species_29438", "species_114632", "Q19523", "WBGene00000068", "O16880", "WBGene00000069", "G5EE33", "WBGene00000070", "Q966F9", "WBGene00000071", "species_114632", "Q19523", "WBGene00000068", "O16880", "WBGene00000069", "G5EE33", "WBGene00000070", "Q966F9", "WBGene00000071", "Q7KPV0", "WBGene00001745", "V6CLB7", "WBGene00020997", "species_29438", "species_114632", "Q19523", "WBGene00000068", "O16880", "WBGene00000069", "G5EE33", "WBGene00000070", "Q966F9", "WBGene00000071" ] }, "reaction_10511363": { "compartment": "compartment_876", "id": "reaction_10511363", "reactome": "R-CEL-170685", "name": "Adenylaye cyclase increases the GTPase activity of G alpha-olf", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10511344" ], "products": [ "species_10511358", "species_29372" ], "modifiers": [ [ "species_10511344", "catalyst" ] ], "additional_components": [ "species_114632", "Q19523", "WBGene00000068", "O16880", "WBGene00000069", "G5EE33", "WBGene00000070", "Q966F9", "WBGene00000071", "Q7KPV0", "WBGene00001745", "V6CLB7", "WBGene00020997", "species_29438", "species_114632", "Q19523", "WBGene00000068", "O16880", "WBGene00000069", "G5EE33", "WBGene00000070", "Q966F9", "WBGene00000071", "Q7KPV0", "WBGene00001745", "V6CLB7", "WBGene00020997", "species_29420", "species_114632", "Q19523", "WBGene00000068", "O16880", "WBGene00000069", "G5EE33", "WBGene00000070", "Q966F9", "WBGene00000071", "Q7KPV0", "WBGene00001745", "V6CLB7", "WBGene00020997", "species_29438" ] }, "reaction_10511356": { "compartment": "compartment_876", "id": "reaction_10511356", "reactome": "R-CEL-170676", "name": "Adenylate cyclase converts ATP into cyclic AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592" ], "products": [ "species_111294", "species_30389" ], "modifiers": [ [ "species_10511344", "catalyst" ] ], "additional_components": [ "species_114632", "Q19523", "WBGene00000068", "O16880", "WBGene00000069", "G5EE33", "WBGene00000070", "Q966F9", "WBGene00000071", "Q7KPV0", "WBGene00001745", "V6CLB7", "WBGene00020997", "species_29438" ] }, "reaction_10509072": { "compartment": "compartment_70101", "id": "reaction_10509072", "reactome": "R-CEL-112037", "name": "Inactivation of PLC beta", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10508939" ], "products": [ "species_10509070", "species_29372", "species_10508913" ], "modifiers": [], "additional_components": [ "G5EBH0", "WBGene00001177", "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196", "species_29438", "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196", "species_29420", "WBGene00001177" ] }, "reaction_10508942": { "compartment": "compartment_70101", "id": "reaction_10508942", "reactome": "R-CEL-111879", "name": "PIP2 hydrolysis", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_179856" ], "products": [ "species_114520", "species_112275" ], "modifiers": [ [ "species_10508939", "catalyst" ] ], "additional_components": [ "G5EBH0", "WBGene00001177", "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196", "species_29438" ] }, "reaction_10509032": { "compartment": "compartment_70101", "id": "reaction_10509032", "reactome": "R-CEL-111962", "name": "PDE4A,C,D hydrolyse cAMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_30389" ], "products": [ "species_76577" ], "modifiers": [ [ "species_10509025", "catalyst" ] ], "additional_components": [ "WBGene00020114" ] }, "reaction_10572525": { "compartment": "compartment_70101", "id": "reaction_10572525", "reactome": "R-CEL-9644869", "name": "p-S54-PDE4B hydrolyses cAMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_30389" ], "products": [ "species_76577" ], "modifiers": [ [ "species_10512059", "catalyst" ] ], "additional_components": [ "WBGene00020114" ] }, "reaction_10512062": { "compartment": "compartment_70101", "id": "reaction_10512062", "reactome": "R-CEL-177284", "name": "PKA phosphorylates PDE4B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10512056" ], "products": [ "species_10512059", "species_29370" ], "modifiers": [ [ "species_10508954", "catalyst" ] ], "additional_components": [ "WBGene00020114", "WBGene00020114", "WBGene00002189" ] }, "reaction_10510834": { "compartment": "compartment_70101", "id": "reaction_10510834", "reactome": "R-CEL-167429", "name": "The receptor:G-protein complex binds GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10510829" ], "products": [ "species_10509169" ], "modifiers": [ [ "species_10508935", "catalyst" ] ], "additional_components": [ "Q20841", "WBGene00018886", "H9G358", "WBGene00018089", "A0A0K3AXD3", "WBGene00011372", "Q23033", "WBGene00020086", "P34311", "WBGene00018089", "A0A2C9C3A4", "WBGene00018089", "Q9XVQ0", "WBGene00018089", "Q09502", "WBGene00008065", "A0A3B1DQQ4", "WBGene00006864", "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "Q20841", "WBGene00018886", "H9G358", "WBGene00018089", "A0A0K3AXD3", "WBGene00011372", "Q23033", "WBGene00020086", "P34311", "WBGene00018089", "A0A2C9C3A4", "WBGene00018089", "Q9XVQ0", "WBGene00018089", "Q09502", "WBGene00008065", "A0A3B1DQQ4", "WBGene00006864", "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196", "species_29438", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196" ] }, "reaction_10510836": { "compartment": "compartment_947587", "id": "reaction_10510836", "reactome": "R-CEL-167433", "name": "G-protein beta-gamma subunits rebind the alpha-GDP subunit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509070", "species_10509165" ], "products": [ "species_10510817" ], "modifiers": [], "additional_components": [ "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196", "species_29420", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196", "species_29420" ] }, "reaction_10510831": { "compartment": "compartment_70101", "id": "reaction_10510831", "reactome": "R-CEL-167419", "name": "The receptor:G-protein complex releases GDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10510819" ], "products": [ "species_10510829", "species_29420" ], "modifiers": [], "additional_components": [ "P17343", "WBGene00001679", "P54406", "WBGene00001681", "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196", "species_29420", "Q20841", "WBGene00018886", "H9G358", "WBGene00018089", "A0A0K3AXD3", "WBGene00011372", "Q23033", "WBGene00020086", "P34311", "WBGene00018089", "A0A2C9C3A4", "WBGene00018089", "Q9XVQ0", "WBGene00018089", "Q09502", "WBGene00008065", "A0A3B1DQQ4", "WBGene00006864", "Q20841", "WBGene00018886", "H9G358", "WBGene00018089", "A0A0K3AXD3", "WBGene00011372", "Q23033", "WBGene00020086", "P34311", "WBGene00018089", "A0A2C9C3A4", "WBGene00018089", "Q9XVQ0", "WBGene00018089", "Q09502", "WBGene00008065", "A0A3B1DQQ4", "WBGene00006864", "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196", "P17343", "WBGene00001679", "P54406", "WBGene00001681" ] }, "reaction_10510815": { "compartment": "compartment_947587", "id": "reaction_10510815", "reactome": "R-CEL-167415", "name": "G-protein alpha subunit is inactivated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29420", "species_10508937" ], "products": [ "species_29438", "species_10509070" ], "modifiers": [ [ "species_10508935", "catalyst" ] ], "additional_components": [ "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196", "species_29438", "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196", "species_29420", "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196" ] }, "reaction_10524194": { "compartment": "compartment_172574", "id": "reaction_10524194", "reactome": "R-CEL-435171", "name": "NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_445829" ], "products": [ "species_445832", "species_1470067" ], "modifiers": [ [ "species_10524191", "catalyst" ] ], "additional_components": [ "species_216785", "species_113531", "species_266099", "species_216785", "species_266099", "species_113531", "Q21433", "WBGene00004877", "Q21434", "WBGene00004876", "Q95XG8", "WBGene00004878" ] }, "reaction_10532076": { "compartment": "compartment_1222693", "id": "reaction_10532076", "reactome": "R-CEL-1222516", "name": "Intraphagosomal pH is lowered to 5 by V-ATPase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106" ], "products": [ "species_1470067" ], "modifiers": [ [ "species_10532073", "catalyst" ] ], "additional_components": [ "Q9XXU9", "WBGene00006920", "Q22494", "WBGene00020507", "Q23680", "WBGene00006918", "P34462", "WBGene00010130", "Q9XW92", "WBGene00013025", "Q19626", "WBGene00006921", "Q9N5A0", "WBGene00004959", "Q95X44", "WBGene00006917", "P91303", "WBGene00006919", "G5EDB8", "WBGene00006913", "Q20591", "WBGene00009882", "C0HLB3", "WBGene00006911", "C0HLB4", "WBGene00006912", "P30628", "WBGene00006768", "B2MZD0", "WBGene00006916", "G5EEK9", "WBGene00006914", "G5EGP4", "WBGene00006915", "Q95YD5", "WBGene00016258" ] }, "reaction_10558402": { "compartment": "compartment_21994", "id": "reaction_10558402", "reactome": "R-CEL-6789031", "name": "Membrane-bound myeloperoxidase (MPO) produces hypochlorous acid (HOCl)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1222719", "species_6788973", "species_1470067" ], "products": [ "species_1222475", "species_6789150" ], "modifiers": [ [ "species_10558399", "catalyst" ] ], "additional_components": [ "P91060", "WBGene00015841", "Q1ENI8", "WBGene00004256", "Q20616", "WBGene00009897", "Q23490", "WBGene00022743", "G5EG78", "WBGene00004257", "H2KZ53", "WBGene00017968", "CHEBI:55376" ] }, "reaction_10558405": { "compartment": "compartment_1222282", "id": "reaction_10558405", "reactome": "R-CEL-6789126", "name": "Myeloperoxidase (MPO) produces hypochlorous acid (HOCl)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1222719", "species_6788973", "species_1470067" ], "products": [ "species_1222475", "species_6789150" ], "modifiers": [ [ "species_10558397", "catalyst" ] ], "additional_components": [ "P91060", "WBGene00015841", "Q1ENI8", "WBGene00004256", "Q20616", "WBGene00009897", "Q23490", "WBGene00022743", "G5EG78", "WBGene00004257", "H2KZ53", "WBGene00017968", "CHEBI:55376" ] }, "reaction_10568119": { "compartment": "compartment_1222282", "id": "reaction_10568119", "reactome": "R-CEL-8933635", "name": "Myeloperoxidase (MPO) catalyzes oxidation of nitrite to nitrogen dioxide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1222719", "species_1470067", "species_6789221" ], "products": [ "species_8933637", "species_1222475" ], "modifiers": [ [ "species_10558397", "catalyst" ] ], "additional_components": [ "P91060", "WBGene00015841", "Q1ENI8", "WBGene00004256", "Q20616", "WBGene00009897", "Q23490", "WBGene00022743", "G5EG78", "WBGene00004257", "H2KZ53", "WBGene00017968", "CHEBI:55376" ] }, "reaction_10558407": { "compartment": "compartment_21994", "id": "reaction_10558407", "reactome": "R-CEL-6789136", "name": "Myeloperoxidase (MPO) binds to the bacterial cell surface", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10558397", "species_983438" ], "products": [ "species_10558399" ], "modifiers": [], "additional_components": [ "P91060", "WBGene00015841", "Q1ENI8", "WBGene00004256", "Q20616", "WBGene00009897", "Q23490", "WBGene00022743", "G5EG78", "WBGene00004257", "H2KZ53", "WBGene00017968", "CHEBI:55376", "P91060", "WBGene00015841", "Q1ENI8", "WBGene00004256", "Q20616", "WBGene00009897", "Q23490", "WBGene00022743", "G5EG78", "WBGene00004257", "H2KZ53", "WBGene00017968", "CHEBI:55376" ] }, "reaction_10565654": { "compartment": "compartment_984", "id": "reaction_10565654", "reactome": "R-CEL-8855490", "name": "Lactoperoxidase (LPO) produces OSCN-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351629", "species_8855492" ], "products": [ "species_109276", "species_8855489" ], "modifiers": [ [ "species_10565651", "catalyst" ] ], "additional_components": [ "G5EG78", "WBGene00004257", "H2KZ53", "WBGene00017968", "P91060", "WBGene00015841", "Q1ENI8", "WBGene00004256", "Q20616", "WBGene00009897", "Q23490", "WBGene00022743", "CHEBI:55376" ] }, "reaction_10573254": { "compartment": "compartment_7660", "id": "reaction_10573254", "reactome": "R-CEL-9699579", "name": "AKT phosphorylates FOXO3 downstream of FLT3 ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10514276" ], "products": [ "species_113582", "species_10514290" ], "modifiers": [ [ "species_10514266", "catalyst" ] ], "additional_components": [ "WBGene00000912", "WBGene00000912", "G4S4W1", "WBGene00016980", "Q17941", "WBGene00000102", "Q9XTG7", "WBGene00000103" ] }, "reaction_10571976": { "compartment": "compartment_70101", "id": "reaction_10571976", "reactome": "R-CEL-9607304", "name": "SOS1-mediated nucleotide exchange of RAS downstream of FLT3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10512175", "species_29438" ], "products": [ "species_29420", "species_10511481" ], "modifiers": [ [ "species_10554987", "catalyst" ] ], "additional_components": [ "species_29420", "P22981", "WBGene00002335", "species_29438", "P22981", "WBGene00002335", "A0A1I6CMA1", "WBGene00020678", "G5EGT9", "WBGene00003007", "P29355", "WBGene00004774", "Q9N5D3", "WBGene00004947" ] }, "reaction_10573256": { "compartment": "compartment_7660", "id": "reaction_10573256", "reactome": "R-CEL-9699581", "name": "AKT-phosphorylated FOXO3 translocates to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10514290" ], "products": [ "species_10572151" ], "modifiers": [], "additional_components": [ "WBGene00000912", "WBGene00000912" ] }, "reaction_10573245": { "compartment": "compartment_876", "id": "reaction_10573245", "reactome": "R-CEL-9698170", "name": "Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508492", "species_10506890" ], "products": [ "species_10543896" ], "modifiers": [], "additional_components": [ "G5EDP9", "WBGene00000001", "A0A1I6CMA1", "WBGene00020678", "G5EGT9", "WBGene00003007", "P29355", "WBGene00004774", "G5EDJ4", "WBGene00004928", "WBGene00000090", "Q94125", "WBGene00000090", "G5EDP9", "WBGene00000001", "A0A1I6CMA1", "WBGene00020678", "G5EGT9", "WBGene00003007", "P29355", "WBGene00004774", "G5EDJ4", "WBGene00004928" ] }, "reaction_10573264": { "compartment": "compartment_70101", "id": "reaction_10573264", "reactome": "R-CEL-9705507", "name": "PDE3B hydrolyses cAMP to AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_30389" ], "products": [ "species_76577" ], "modifiers": [ [ "species_10573261", "catalyst" ] ], "additional_components": [ "WBGene00008443" ] }, "reaction_10572293": { "compartment": "compartment_70101", "id": "reaction_10572293", "reactome": "R-CEL-9629675", "name": "PDE3A hydrolyses cAMP to AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_30389" ], "products": [ "species_76577" ], "modifiers": [ [ "species_10572290", "catalyst" ] ], "additional_components": [ "WBGene00008443" ] }, "reaction_10573321": { "compartment": "compartment_70101", "id": "reaction_10573321", "reactome": "R-CEL-9708261", "name": "PDE4A hydrolyses cAMP to AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_30389" ], "products": [ "species_76577" ], "modifiers": [ [ "species_10509025", "catalyst" ] ], "additional_components": [ "WBGene00020114" ] }, "reaction_10521818": { "compartment": "compartment_70101", "id": "reaction_10521818", "reactome": "R-CEL-418553", "name": "cAMP degradation by Phosphodiesterases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_30389" ], "products": [ "species_76577" ], "modifiers": [ [ "species_10521815", "catalyst" ] ], "additional_components": [ "Q22000", "WBGene00020114", "Q9N2V9", "WBGene00022389", "P30645", "WBGene00011146", "P91119", "WBGene00016328", "O18696", "WBGene00011433" ] }, "reaction_10571834": { "compartment": "compartment_70101", "id": "reaction_10571834", "reactome": "R-CEL-9603279", "name": "PIP3 recruits PDK1 and AKT to the membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179838", "species_10515193", "species_10520802" ], "products": [ "species_10571832" ], "modifiers": [], "additional_components": [ "WBGene00021022", "G4S4W1", "WBGene00016980", "Q17941", "WBGene00000102", "Q9XTG7", "WBGene00000103", "Q9UA62", "WBGene00021022", "Q17941", "WBGene00000102", "Q9XTG7", "WBGene00000103", "G4S4W1", "WBGene00016980", "species_179838" ] }, "reaction_10521037": { "compartment": "compartment_70101", "id": "reaction_10521037", "reactome": "R-CEL-392300", "name": "G beta:gamma activated PI3Kgamma converts PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10521034", "catalyst" ] ], "additional_components": [ "Q94125", "WBGene00000090", "P17343", "WBGene00001679", "P54406", "WBGene00001681" ] }, "reaction_10570240": { "compartment": "compartment_876", "id": "reaction_10570240", "reactome": "R-CEL-8964634", "name": "CDC42 binds GNB/GNG:PAK1:ARHGEF6 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10570223", "species_10512277" ], "products": [ "species_10570229" ], "modifiers": [], "additional_components": [ "Q21430", "WBGene00010776", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "WBGene00000390", "Q05062", "WBGene00000390", "Q21430", "WBGene00010776", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "P17343", "WBGene00001679", "P54406", "WBGene00001681" ] }, "reaction_10570227": { "compartment": "compartment_876", "id": "reaction_10570227", "reactome": "R-CEL-8964599", "name": "Active PAK1 and Active CDC42 dissociates from GNB/GNG:PAK1:ARHGEF6:CDC42 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10570225" ], "products": [ "species_10520670", "species_10509165", "species_10516119", "species_10512279" ], "modifiers": [], "additional_components": [ "Q05062", "WBGene00000390", "species_29438", "Q21430", "WBGene00010776", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "WBGene00010776", "Q05062", "WBGene00000390", "species_29438" ] }, "reaction_10570232": { "compartment": "compartment_876", "id": "reaction_10570232", "reactome": "R-CEL-8964604", "name": "CDC42 in GNB/GNG:PAK1:ARHGEF6:CDC42 is activated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10570229" ], "products": [ "species_10570225" ], "modifiers": [ [ "species_10570229", "catalyst" ] ], "additional_components": [ "Q05062", "WBGene00000390", "Q21430", "WBGene00010776", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "Q05062", "WBGene00000390", "species_29438", "Q21430", "WBGene00010776", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "Q05062", "WBGene00000390", "Q21430", "WBGene00010776", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "P17343", "WBGene00001679", "P54406", "WBGene00001681" ] }, "reaction_10570234": { "compartment": "compartment_70101", "id": "reaction_10570234", "reactome": "R-CEL-8964605", "name": "PAK1:ARHGEF6 complex binds G-protein beta-gamma complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509165", "species_10570221" ], "products": [ "species_10570223" ], "modifiers": [], "additional_components": [ "P17343", "WBGene00001679", "P54406", "WBGene00001681", "Q21430", "WBGene00010776", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "Q21430", "WBGene00010776", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "P17343", "WBGene00001679", "P54406", "WBGene00001681" ] }, "reaction_10570236": { "compartment": "compartment_876", "id": "reaction_10570236", "reactome": "R-CEL-8964614", "name": "PAK1 in GNB/GNG:PAK1:ARHGEF6:Active CDC42 is activated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10570225" ], "products": [ "species_10570225" ], "modifiers": [], "additional_components": [ "Q05062", "WBGene00000390", "species_29438", "Q21430", "WBGene00010776", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "Q05062", "WBGene00000390", "species_29438", "Q21430", "WBGene00010776", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "P17343", "WBGene00001679", "P54406", "WBGene00001681" ] }, "reaction_10570238": { "compartment": "compartment_70101", "id": "reaction_10570238", "reactome": "R-CEL-8964619", "name": "PAK1 binds ARHGEF6", "reversible": "false", "notes": "", "reactants": [ "species_10520670", "species_10516119" ], "products": [ "species_10570221" ], "modifiers": [], "additional_components": [ "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "WBGene00010776", "Q21430", "WBGene00010776", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911" ] }, "reaction_10528036": { "compartment": "compartment_876", "id": "reaction_10528036", "reactome": "R-CEL-751001", "name": "Inactive G alpha (i) reassociates with G beta:gamma", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509165", "species_10511349" ], "products": [ "species_10519835" ], "modifiers": [], "additional_components": [ "P17343", "WBGene00001679", "P54406", "WBGene00001681", "species_29420", "O76584", "WBGene00001673", "Q9BIG5", "WBGene00001666", "Q21917", "WBGene00001669", "P91907", "WBGene00001677", "Q93743", "WBGene00001668", "Q20907", "WBGene00001670", "Q9BIG2", "WBGene00001676", "Q20910", "WBGene00001671", "species_29420", "O76584", "WBGene00001673", "Q9BIG5", "WBGene00001666", "Q21917", "WBGene00001669", "P91907", "WBGene00001677", "Q93743", "WBGene00001668", "Q20907", "WBGene00001670", "Q9BIG2", "WBGene00001676", "Q20910", "WBGene00001671", "P17343", "WBGene00001679", "P54406", "WBGene00001681" ] }, "reaction_10570486": { "compartment": "compartment_876", "id": "reaction_10570486", "reactome": "R-CEL-8982019", "name": "Active G alpha (i)i1/i2/i3 binds RGS proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10570468", "species_10511329" ], "products": [ "species_10570484" ], "modifiers": [], "additional_components": [ "Q18563", "WBGene00004349", "G5ECK9", "WBGene00004351", "Q23376", "WBGene00004352", "O45523", "WBGene00004353", "Q8WQC0", "WBGene00004350", "O45524", "WBGene00004354", "P49808", "WBGene00004345", "P49809", "WBGene00001179", "A0A5S9MNH1", "WBGene00004347", "O17589", "WBGene00001145", "species_29438", "O76584", "WBGene00001673", "Q9BIG5", "WBGene00001666", "Q21917", "WBGene00001669", "P91907", "WBGene00001677", "Q93743", "WBGene00001668", "Q20907", "WBGene00001670", "Q9BIG2", "WBGene00001676", "Q20910", "WBGene00001671", "species_29438", "O76584", "WBGene00001673", "Q9BIG5", "WBGene00001666", "Q21917", "WBGene00001669", "P91907", "WBGene00001677", "Q93743", "WBGene00001668", "Q20907", "WBGene00001670", "Q9BIG2", "WBGene00001676", "Q20910", "WBGene00001671", "Q18563", "WBGene00004349", "G5ECK9", "WBGene00004351", "Q23376", "WBGene00004352", "O45523", "WBGene00004353", "Q8WQC0", "WBGene00004350", "O45524", "WBGene00004354", "P49808", "WBGene00004345", "P49809", "WBGene00001179", "A0A5S9MNH1", "WBGene00004347", "O17589", "WBGene00001145" ] }, "reaction_10570217": { "compartment": "compartment_876", "id": "reaction_10570217", "reactome": "R-CEL-8964242", "name": "G protein alpha (i)-SRC complex catalyzes SRC to p-Y416-SRC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10570204", "species_113592" ], "products": [ "species_29370", "species_10570214" ], "modifiers": [ [ "species_10570204", "catalyst" ] ], "additional_components": [ "species_29438", "O76584", "WBGene00001673", "Q9BIG5", "WBGene00001666", "Q21917", "WBGene00001669", "P91907", "WBGene00001677", "Q93743", "WBGene00001668", "Q20907", "WBGene00001670", "Q9BIG2", "WBGene00001676", "Q20910", "WBGene00001671", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "species_29438", "O76584", "WBGene00001673", "Q9BIG5", "WBGene00001666", "Q21917", "WBGene00001669", "P91907", "WBGene00001677", "Q93743", "WBGene00001668", "Q20907", "WBGene00001670", "Q9BIG2", "WBGene00001676", "Q20910", "WBGene00001671", "Q9N3S5", "WBGene00021635", "G5EE56", "WBGene00005077", "species_29438", "O76584", "WBGene00001673", "Q9BIG5", "WBGene00001666", "Q21917", "WBGene00001669", "P91907", "WBGene00001677", "Q93743", "WBGene00001668", "Q20907", "WBGene00001670", "Q9BIG2", "WBGene00001676", "Q20910", "WBGene00001671", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635" ] }, "reaction_10570489": { "compartment": "compartment_876", "id": "reaction_10570489", "reactome": "R-CEL-8982020", "name": "G alpha (i)i1/i2/i3 in G (i):RGS complex is inactivated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10570484" ], "products": [ "species_29372", "species_10570470" ], "modifiers": [ [ "species_10570484", "catalyst" ] ], "additional_components": [ "species_29438", "O76584", "WBGene00001673", "Q9BIG5", "WBGene00001666", "Q21917", "WBGene00001669", "P91907", "WBGene00001677", "Q93743", "WBGene00001668", "Q20907", "WBGene00001670", "Q9BIG2", "WBGene00001676", "Q20910", "WBGene00001671", "Q18563", "WBGene00004349", "G5ECK9", "WBGene00004351", "Q23376", "WBGene00004352", "O45523", "WBGene00004353", "Q8WQC0", "WBGene00004350", "O45524", "WBGene00004354", "P49808", "WBGene00004345", "P49809", "WBGene00001179", "A0A5S9MNH1", "WBGene00004347", "O17589", "WBGene00001145", "Q18563", "WBGene00004349", "G5ECK9", "WBGene00004351", "Q23376", "WBGene00004352", "O45523", "WBGene00004353", "Q8WQC0", "WBGene00004350", "O45524", "WBGene00004354", "P49808", "WBGene00004345", "P49809", "WBGene00001179", "A0A5S9MNH1", "WBGene00004347", "O17589", "WBGene00001145", "species_29420", "O76584", "WBGene00001673", "Q9BIG5", "WBGene00001666", "Q21917", "WBGene00001669", "P91907", "WBGene00001677", "Q93743", "WBGene00001668", "Q20907", "WBGene00001670", "Q9BIG2", "WBGene00001676", "Q20910", "WBGene00001671", "species_29438", "O76584", "WBGene00001673", "Q9BIG5", "WBGene00001666", "Q21917", "WBGene00001669", "P91907", "WBGene00001677", "Q93743", "WBGene00001668", "Q20907", "WBGene00001670", "Q9BIG2", "WBGene00001676", "Q20910", "WBGene00001671", "Q18563", "WBGene00004349", "G5ECK9", "WBGene00004351", "Q23376", "WBGene00004352", "O45523", "WBGene00004353", "Q8WQC0", "WBGene00004350", "O45524", "WBGene00004354", "P49808", "WBGene00004345", "P49809", "WBGene00001179", "A0A5S9MNH1", "WBGene00004347", "O17589", "WBGene00001145" ] }, "reaction_10570472": { "compartment": "compartment_876", "id": "reaction_10570472", "reactome": "R-CEL-8982012", "name": "G alpha (i):RGS dissociates to inactive G alpha (i)i1/i2/i3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10570470" ], "products": [ "species_10511349", "species_10570468" ], "modifiers": [], "additional_components": [ "Q18563", "WBGene00004349", "G5ECK9", "WBGene00004351", "Q23376", "WBGene00004352", "O45523", "WBGene00004353", "Q8WQC0", "WBGene00004350", "O45524", "WBGene00004354", "P49808", "WBGene00004345", "P49809", "WBGene00001179", "A0A5S9MNH1", "WBGene00004347", "O17589", "WBGene00001145", "species_29420", "O76584", "WBGene00001673", "Q9BIG5", "WBGene00001666", "Q21917", "WBGene00001669", "P91907", "WBGene00001677", "Q93743", "WBGene00001668", "Q20907", "WBGene00001670", "Q9BIG2", "WBGene00001676", "Q20910", "WBGene00001671", "species_29420", "O76584", "WBGene00001673", "Q9BIG5", "WBGene00001666", "Q21917", "WBGene00001669", "P91907", "WBGene00001677", "Q93743", "WBGene00001668", "Q20907", "WBGene00001670", "Q9BIG2", "WBGene00001676", "Q20910", "WBGene00001671", "Q18563", "WBGene00004349", "G5ECK9", "WBGene00004351", "Q23376", "WBGene00004352", "O45523", "WBGene00004353", "Q8WQC0", "WBGene00004350", "O45524", "WBGene00004354", "P49808", "WBGene00004345", "P49809", "WBGene00001179", "A0A5S9MNH1", "WBGene00004347", "O17589", "WBGene00001145" ] }, "reaction_10570219": { "compartment": "compartment_70101", "id": "reaction_10570219", "reactome": "R-CEL-8964329", "name": "G protein alpha (i)-SRC complex dissociates to G protein alpha (i) and Active SRC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10570214" ], "products": [ "species_10570212", "species_10511329" ], "modifiers": [], "additional_components": [ "species_29438", "O76584", "WBGene00001673", "Q9BIG5", "WBGene00001666", "Q21917", "WBGene00001669", "P91907", "WBGene00001677", "Q93743", "WBGene00001668", "Q20907", "WBGene00001670", "Q9BIG2", "WBGene00001676", "Q20910", "WBGene00001671", "Q9N3S5", "WBGene00021635", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "G5EE56", "WBGene00005077", "species_29438", "O76584", "WBGene00001673", "Q9BIG5", "WBGene00001666", "Q21917", "WBGene00001669", "P91907", "WBGene00001677", "Q93743", "WBGene00001668", "Q20907", "WBGene00001670", "Q9BIG2", "WBGene00001676", "Q20910", "WBGene00001671" ] }, "reaction_10519851": { "compartment": "compartment_947587", "id": "reaction_10519851", "reactome": "R-CEL-380073", "name": "Liganded Gi-activating GPCR acts as a GEF for Gi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10519837" ], "products": [ "species_29420", "species_10519841" ], "modifiers": [ [ "species_10519837", "catalyst" ], [ "species_10519847", "inhibitor" ] ], "additional_components": [ "species_390899", "Q9U7D5", "WBGene00001519", "species_266074", "species_266013", "CHEBI:15650", "H2KZ99", "WBGene00016570", "O02213", "WBGene00004777", "Q19084", "WBGene00017157", "species_209794", "species_209789", "Q23033", "WBGene00020086", "A0A0K3AXD3", "WBGene00011372", "Q9XVQ0", "WBGene00018089", "A0A2C9C3A4", "WBGene00018089", "A0A3B1DQQ4", "WBGene00006864", "H9G358", "WBGene00018089", "P34311", "WBGene00018089", "Q09502", "WBGene00008065", "Q20841", "WBGene00018886", "species_879629", "G5ECB2", "WBGene00022675", "H2L0Q3", "WBGene00021528", "species_352003", "A1IMB8", "WBGene00021152", "Q09630", "WBGene00003232", "species_113552", "species_372533", "Q7JP61", "WBGene00006411", "E7EM37", "WBGene00001053", "G5EGH0", "WBGene00004779", "species_380585", "species_351601", "Q6RYS9", "WBGene00020506", "species_83909", "Q10042", "WBGene00019287", "Q19295", "WBGene00019287", "Q19779", "WBGene00017779", "Q1ZXT2", "WBGene00011878", "species_29420", "O76584", "WBGene00001673", "Q9BIG5", "WBGene00001666", "Q21917", "WBGene00001669", "P91907", "WBGene00001677", "Q93743", "WBGene00001668", "Q20907", "WBGene00001670", "Q9BIG2", "WBGene00001676", "Q20910", "WBGene00001671", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "species_390899", "Q9U7D5", "WBGene00001519", "species_266074", "species_266013", "CHEBI:15650", "H2KZ99", "WBGene00016570", "O02213", "WBGene00004777", "Q19084", "WBGene00017157", "species_209794", "species_209789", "Q23033", "WBGene00020086", "A0A0K3AXD3", "WBGene00011372", "Q9XVQ0", "WBGene00018089", "A0A2C9C3A4", "WBGene00018089", "A0A3B1DQQ4", "WBGene00006864", "H9G358", "WBGene00018089", "P34311", "WBGene00018089", "Q09502", "WBGene00008065", "Q20841", "WBGene00018886", "species_879629", "G5ECB2", "WBGene00022675", "H2L0Q3", "WBGene00021528", "species_352003", "A1IMB8", "WBGene00021152", "Q09630", "WBGene00003232", "species_113552", "species_372533", "Q7JP61", "WBGene00006411", "E7EM37", "WBGene00001053", "G5EGH0", "WBGene00004779", "species_380585", "species_351601", "Q6RYS9", "WBGene00020506", "species_83909", "Q10042", "WBGene00019287", "Q19295", "WBGene00019287", "Q19779", "WBGene00017779", "Q1ZXT2", "WBGene00011878", "species_29438", "O76584", "WBGene00001673", "Q9BIG5", "WBGene00001666", "Q21917", "WBGene00001669", "P91907", "WBGene00001677", "Q93743", "WBGene00001668", "Q20907", "WBGene00001670", "Q9BIG2", "WBGene00001676", "Q20910", "WBGene00001671", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "species_390899", "Q9U7D5", "WBGene00001519", "species_266074", "species_266013", "CHEBI:15650", "H2KZ99", "WBGene00016570", "O02213", "WBGene00004777", "Q19084", "WBGene00017157", "species_209794", "species_209789", "Q23033", "WBGene00020086", "A0A0K3AXD3", "WBGene00011372", "Q9XVQ0", "WBGene00018089", "A0A2C9C3A4", "WBGene00018089", "A0A3B1DQQ4", "WBGene00006864", "H9G358", "WBGene00018089", "P34311", "WBGene00018089", "Q09502", "WBGene00008065", "Q20841", "WBGene00018886", "species_879629", "G5ECB2", "WBGene00022675", "H2L0Q3", "WBGene00021528", "species_352003", "A1IMB8", "WBGene00021152", "Q09630", "WBGene00003232", "species_113552", "species_372533", "Q7JP61", "WBGene00006411", "E7EM37", "WBGene00001053", "G5EGH0", "WBGene00004779", "species_380585", "species_351601", "Q6RYS9", "WBGene00020506", "species_83909", "Q10042", "WBGene00019287", "Q19295", "WBGene00019287", "Q19779", "WBGene00017779", "Q1ZXT2", "WBGene00011878", "species_29420", "O76584", "WBGene00001673", "Q9BIG5", "WBGene00001666", "Q21917", "WBGene00001669", "P91907", "WBGene00001677", "Q93743", "WBGene00001668", "Q20907", "WBGene00001670", "Q9BIG2", "WBGene00001676", "Q20910", "WBGene00001671", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "WBGene00000092" ] }, "reaction_10528028": { "compartment": "compartment_984", "id": "reaction_10528028", "reactome": "R-CEL-749454", "name": "The Ligand:GPCR:Gi complex dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10519841" ], "products": [ "species_10509165", "species_10519833", "species_10511329" ], "modifiers": [], "additional_components": [ "species_390899", "Q9U7D5", "WBGene00001519", "species_266074", "species_266013", "CHEBI:15650", "H2KZ99", "WBGene00016570", "O02213", "WBGene00004777", "Q19084", "WBGene00017157", "species_209794", "species_209789", "Q23033", "WBGene00020086", "A0A0K3AXD3", "WBGene00011372", "Q9XVQ0", "WBGene00018089", "A0A2C9C3A4", "WBGene00018089", "A0A3B1DQQ4", "WBGene00006864", "H9G358", "WBGene00018089", "P34311", "WBGene00018089", "Q09502", "WBGene00008065", "Q20841", "WBGene00018886", "species_879629", "G5ECB2", "WBGene00022675", "H2L0Q3", "WBGene00021528", "species_352003", "A1IMB8", "WBGene00021152", "Q09630", "WBGene00003232", "species_113552", "species_372533", "Q7JP61", "WBGene00006411", "E7EM37", "WBGene00001053", "G5EGH0", "WBGene00004779", "species_380585", "species_351601", "Q6RYS9", "WBGene00020506", "species_83909", "Q10042", "WBGene00019287", "Q19295", "WBGene00019287", "Q19779", "WBGene00017779", "Q1ZXT2", "WBGene00011878", "species_29438", "O76584", "WBGene00001673", "Q9BIG5", "WBGene00001666", "Q21917", "WBGene00001669", "P91907", "WBGene00001677", "Q93743", "WBGene00001668", "Q20907", "WBGene00001670", "Q9BIG2", "WBGene00001676", "Q20910", "WBGene00001671", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "species_390899", "Q9U7D5", "WBGene00001519", "species_266074", "species_266013", "CHEBI:15650", "H2KZ99", "WBGene00016570", "O02213", "WBGene00004777", "Q19084", "WBGene00017157", "species_209794", "species_209789", "Q23033", "WBGene00020086", "A0A0K3AXD3", "WBGene00011372", "Q9XVQ0", "WBGene00018089", "A0A2C9C3A4", "WBGene00018089", "A0A3B1DQQ4", "WBGene00006864", "H9G358", "WBGene00018089", "P34311", "WBGene00018089", "Q09502", "WBGene00008065", "Q20841", "WBGene00018886", "species_879629", "G5ECB2", "WBGene00022675", "H2L0Q3", "WBGene00021528", "species_352003", "A1IMB8", "WBGene00021152", "Q09630", "WBGene00003232", "species_113552", "species_372533", "Q7JP61", "WBGene00006411", "E7EM37", "WBGene00001053", "G5EGH0", "WBGene00004779", "species_380585", "species_351601", "Q6RYS9", "WBGene00020506", "species_83909", "Q10042", "WBGene00019287", "Q19295", "WBGene00019287", "Q19779", "WBGene00017779", "Q1ZXT2", "WBGene00011878", "species_29438", "O76584", "WBGene00001673", "Q9BIG5", "WBGene00001666", "Q21917", "WBGene00001669", "P91907", "WBGene00001677", "Q93743", "WBGene00001668", "Q20907", "WBGene00001670", "Q9BIG2", "WBGene00001676", "Q20910", "WBGene00001671" ] }, "reaction_10528030": { "compartment": "compartment_876", "id": "reaction_10528030", "reactome": "R-CEL-749456", "name": "Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10519835", "species_10519833" ], "products": [ "species_10519837" ], "modifiers": [], "additional_components": [ "species_29420", "O76584", "WBGene00001673", "Q9BIG5", "WBGene00001666", "Q21917", "WBGene00001669", "P91907", "WBGene00001677", "Q93743", "WBGene00001668", "Q20907", "WBGene00001670", "Q9BIG2", "WBGene00001676", "Q20910", "WBGene00001671", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "species_390899", "Q9U7D5", "WBGene00001519", "species_266074", "species_266013", "CHEBI:15650", "H2KZ99", "WBGene00016570", "O02213", "WBGene00004777", "Q19084", "WBGene00017157", "species_209794", "species_209789", "Q23033", "WBGene00020086", "A0A0K3AXD3", "WBGene00011372", "Q9XVQ0", "WBGene00018089", "A0A2C9C3A4", "WBGene00018089", "A0A3B1DQQ4", "WBGene00006864", "H9G358", "WBGene00018089", "P34311", "WBGene00018089", "Q09502", "WBGene00008065", "Q20841", "WBGene00018886", "species_879629", "G5ECB2", "WBGene00022675", "H2L0Q3", "WBGene00021528", "species_352003", "A1IMB8", "WBGene00021152", "Q09630", "WBGene00003232", "species_113552", "species_372533", "Q7JP61", "WBGene00006411", "E7EM37", "WBGene00001053", "G5EGH0", "WBGene00004779", "species_380585", "species_351601", "Q6RYS9", "WBGene00020506", "species_83909", "Q10042", "WBGene00019287", "Q19295", "WBGene00019287", "Q19779", "WBGene00017779", "Q1ZXT2", "WBGene00011878", "species_390899", "Q9U7D5", "WBGene00001519", "species_266074", "species_266013", "CHEBI:15650", "H2KZ99", "WBGene00016570", "O02213", "WBGene00004777", "Q19084", "WBGene00017157", "species_209794", "species_209789", "Q23033", "WBGene00020086", "A0A0K3AXD3", "WBGene00011372", "Q9XVQ0", "WBGene00018089", "A0A2C9C3A4", "WBGene00018089", "A0A3B1DQQ4", "WBGene00006864", "H9G358", "WBGene00018089", "P34311", "WBGene00018089", "Q09502", "WBGene00008065", "Q20841", "WBGene00018886", "species_879629", "G5ECB2", "WBGene00022675", "H2L0Q3", "WBGene00021528", "species_352003", "A1IMB8", "WBGene00021152", "Q09630", "WBGene00003232", "species_113552", "species_372533", "Q7JP61", "WBGene00006411", "E7EM37", "WBGene00001053", "G5EGH0", "WBGene00004779", "species_380585", "species_351601", "Q6RYS9", "WBGene00020506", "species_83909", "Q10042", "WBGene00019287", "Q19295", "WBGene00019287", "Q19779", "WBGene00017779", "Q1ZXT2", "WBGene00011878", "species_29420", "O76584", "WBGene00001673", "Q9BIG5", "WBGene00001666", "Q21917", "WBGene00001669", "P91907", "WBGene00001677", "Q93743", "WBGene00001668", "Q20907", "WBGene00001670", "Q9BIG2", "WBGene00001676", "Q20910", "WBGene00001671", "P17343", "WBGene00001679", "P54406", "WBGene00001681" ] }, "reaction_10570497": { "compartment": "compartment_876", "id": "reaction_10570497", "reactome": "R-CEL-8982025", "name": "G alpha (q) in G (q):RGS complex is inactivated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10570476" ], "products": [ "species_10570494", "species_29372" ], "modifiers": [ [ "species_10570476", "catalyst" ] ], "additional_components": [ "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196", "species_29438", "Q18563", "WBGene00004349", "G5ECK9", "WBGene00004351", "Q23376", "WBGene00004352", "O45523", "WBGene00004353", "Q8WQC0", "WBGene00004350", "O45524", "WBGene00004354", "P49808", "WBGene00004345", "A0A5S9MNH1", "WBGene00004347", "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196", "Q18563", "WBGene00004349", "G5ECK9", "WBGene00004351", "Q23376", "WBGene00004352", "O45523", "WBGene00004353", "Q8WQC0", "WBGene00004350", "O45524", "WBGene00004354", "P49808", "WBGene00004345", "A0A5S9MNH1", "WBGene00004347", "species_29420", "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196", "species_29438", "Q18563", "WBGene00004349", "G5ECK9", "WBGene00004351", "Q23376", "WBGene00004352", "O45523", "WBGene00004353", "Q8WQC0", "WBGene00004350", "O45524", "WBGene00004354", "P49808", "WBGene00004345", "A0A5S9MNH1", "WBGene00004347" ] }, "reaction_10519681": { "compartment": "compartment_70101", "id": "reaction_10519681", "reactome": "R-CEL-379048", "name": "Liganded Gq/11-activating GPCRs act as GEFs for Gq/11", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10519672" ], "products": [ "species_29420", "species_10519674" ], "modifiers": [ [ "species_10519678", "catalyst" ] ], "additional_components": [ "species_266056", "Q20325", "WBGene00018344", "Q9XUK8", "WBGene00012275", "P91096", "WBGene00016037", "species_380585", "species_266074", "species_266013", "CHEBI:15650", "H2KZ99", "WBGene00016570", "species_70106", "species_417891", "G5EG10", "WBGene00003233", "species_113552", "species_372533", "Q9U7D5", "WBGene00001519", "CHEBI:28716", "species_390435", "CHEBI:28875", "CHEBI:53460", "CHEBI:27997", "CHEBI:16196", "species_2066763", "CHEBI:53487", "CHEBI:53486", "species_8934421", "CHEBI:53488", "CHEBI:28661", "CHEBI:28364", "CHEBI:27432", "O17899", "WBGene00010329", "species_158602", "species_419777", "P90745", "WBGene00007006", "species_209794", "species_209789", "G5EBX8", "WBGene00008890", "species_29420", "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "species_266056", "Q20325", "WBGene00018344", "Q9XUK8", "WBGene00012275", "P91096", "WBGene00016037", "species_380585", "species_266074", "species_266013", "CHEBI:15650", "H2KZ99", "WBGene00016570", "species_70106", "species_417891", "G5EG10", "WBGene00003233", "species_113552", "species_372533", "Q9U7D5", "WBGene00001519", "CHEBI:28716", "species_390435", "CHEBI:28875", "CHEBI:53460", "CHEBI:27997", "CHEBI:16196", "species_2066763", "CHEBI:53487", "CHEBI:53486", "species_8934421", "CHEBI:53488", "CHEBI:28661", "CHEBI:28364", "CHEBI:27432", "O17899", "WBGene00010329", "species_158602", "species_419777", "P90745", "WBGene00007006", "species_209794", "species_209789", "G5EBX8", "WBGene00008890", "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196", "species_29438", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "species_266013", "Q20325", "WBGene00018344", "Q9XUK8", "WBGene00012275" ] }, "reaction_10528034": { "compartment": "compartment_876", "id": "reaction_10528034", "reactome": "R-CEL-750993", "name": "Inactive G alpha (q) reassociates with G beta:gamma", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509165", "species_10509557" ], "products": [ "species_10509559" ], "modifiers": [], "additional_components": [ "P17343", "WBGene00001679", "P54406", "WBGene00001681", "species_29420", "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196", "species_29420", "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196", "P17343", "WBGene00001679", "P54406", "WBGene00001681" ] }, "reaction_10570499": { "compartment": "compartment_876", "id": "reaction_10570499", "reactome": "R-CEL-8982026", "name": "G alpha (q):RGS dissociates to inactive G alpha (q)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10570494" ], "products": [ "species_10570474", "species_10509557" ], "modifiers": [], "additional_components": [ "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196", "Q18563", "WBGene00004349", "G5ECK9", "WBGene00004351", "Q23376", "WBGene00004352", "O45523", "WBGene00004353", "Q8WQC0", "WBGene00004350", "O45524", "WBGene00004354", "P49808", "WBGene00004345", "A0A5S9MNH1", "WBGene00004347", "species_29420", "Q18563", "WBGene00004349", "G5ECK9", "WBGene00004351", "Q23376", "WBGene00004352", "O45523", "WBGene00004353", "Q8WQC0", "WBGene00004350", "O45524", "WBGene00004354", "P49808", "WBGene00004345", "A0A5S9MNH1", "WBGene00004347", "species_29420", "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196" ] }, "reaction_10521540": { "compartment": "compartment_70101", "id": "reaction_10521540", "reactome": "R-CEL-400586", "name": "G alpha (q) binds to Trio family RhoGEFs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508937", "species_10521536" ], "products": [ "species_10521538" ], "modifiers": [], "additional_components": [ "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196", "species_29438", "WBGene00006805", "O61528", "WBGene00006805", "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196", "species_29438" ] }, "reaction_10527910": { "compartment": "compartment_876", "id": "reaction_10527910", "reactome": "R-CEL-749448", "name": "Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509559", "species_10519670" ], "products": [ "species_10519672" ], "modifiers": [], "additional_components": [ "species_29420", "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "species_266056", "Q20325", "WBGene00018344", "Q9XUK8", "WBGene00012275", "P91096", "WBGene00016037", "species_380585", "species_266074", "species_266013", "CHEBI:15650", "H2KZ99", "WBGene00016570", "species_70106", "species_417891", "G5EG10", "WBGene00003233", "species_113552", "species_372533", "Q9U7D5", "WBGene00001519", "CHEBI:28716", "species_390435", "CHEBI:28875", "CHEBI:53460", "CHEBI:27997", "CHEBI:16196", "species_2066763", "CHEBI:53487", "CHEBI:53486", "species_8934421", "CHEBI:53488", "CHEBI:28661", "CHEBI:28364", "CHEBI:27432", "O17899", "WBGene00010329", "species_158602", "species_419777", "P90745", "WBGene00007006", "species_209794", "species_209789", "G5EBX8", "WBGene00008890", "species_266056", "Q20325", "WBGene00018344", "Q9XUK8", "WBGene00012275", "P91096", "WBGene00016037", "species_380585", "species_266074", "species_266013", "CHEBI:15650", "H2KZ99", "WBGene00016570", "species_70106", "species_417891", "G5EG10", "WBGene00003233", "species_113552", "species_372533", "Q9U7D5", "WBGene00001519", "CHEBI:28716", "species_390435", "CHEBI:28875", "CHEBI:53460", "CHEBI:27997", "CHEBI:16196", "species_2066763", "CHEBI:53487", "CHEBI:53486", "species_8934421", "CHEBI:53488", "CHEBI:28661", "CHEBI:28364", "CHEBI:27432", "O17899", "WBGene00010329", "species_158602", "species_419777", "P90745", "WBGene00007006", "species_209794", "species_209789", "G5EBX8", "WBGene00008890", "species_29420", "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196", "P17343", "WBGene00001679", "P54406", "WBGene00001681" ] }, "reaction_10543427": { "compartment": "compartment_70101", "id": "reaction_10543427", "reactome": "R-CEL-2179407", "name": "SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10512175", "species_29438" ], "products": [ "species_29420", "species_10511481" ], "modifiers": [ [ "species_10543424", "catalyst" ] ], "additional_components": [ "species_29420", "P22981", "WBGene00002335", "species_29438", "P22981", "WBGene00002335", "P29355", "WBGene00004774", "Q9N5D3", "WBGene00004947", "P24348", "WBGene00002299" ] }, "reaction_10543444": { "compartment": "compartment_876", "id": "reaction_10543444", "reactome": "R-CEL-2179413", "name": "Activated PKC-alpha activate MMP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10543441" ], "products": [ "species_10534164" ], "modifiers": [ [ "species_10521475", "catalyst" ] ], "additional_components": [ "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "Q21182", "WBGene00194737", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "P90980", "WBGene00004033", "species_114519" ] }, "reaction_10521477": { "compartment": "compartment_876", "id": "reaction_10521477", "reactome": "R-CEL-400015", "name": "Diacylgycerol activates Protein kinase C, alpha type", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_114519", "species_10509044" ], "products": [ "species_10521475" ], "modifiers": [], "additional_components": [ "WBGene00004033", "P90980", "WBGene00004033", "species_114519" ] }, "reaction_10570478": { "compartment": "compartment_876", "id": "reaction_10570478", "reactome": "R-CEL-8982017", "name": "Active G alpha (q) binds RGS proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10570474", "species_10508937" ], "products": [ "species_10570476" ], "modifiers": [], "additional_components": [ "Q18563", "WBGene00004349", "G5ECK9", "WBGene00004351", "Q23376", "WBGene00004352", "O45523", "WBGene00004353", "Q8WQC0", "WBGene00004350", "O45524", "WBGene00004354", "P49808", "WBGene00004345", "A0A5S9MNH1", "WBGene00004347", "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196", "species_29438", "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196", "species_29438", "Q18563", "WBGene00004349", "G5ECK9", "WBGene00004351", "Q23376", "WBGene00004352", "O45523", "WBGene00004353", "Q8WQC0", "WBGene00004350", "O45524", "WBGene00004354", "P49808", "WBGene00004345", "A0A5S9MNH1", "WBGene00004347" ] }, "reaction_10528019": { "compartment": "compartment_984", "id": "reaction_10528019", "reactome": "R-CEL-749452", "name": "The Ligand:GPCR:Gq complex dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10519674" ], "products": [ "species_10509165", "species_10527995", "species_10508937", "species_10528017" ], "modifiers": [], "additional_components": [ "species_266056", "Q20325", "WBGene00018344", "Q9XUK8", "WBGene00012275", "P91096", "WBGene00016037", "species_380585", "species_266074", "species_266013", "CHEBI:15650", "H2KZ99", "WBGene00016570", "species_70106", "species_417891", "G5EG10", "WBGene00003233", "species_113552", "species_372533", "Q9U7D5", "WBGene00001519", "CHEBI:28716", "species_390435", "CHEBI:28875", "CHEBI:53460", "CHEBI:27997", "CHEBI:16196", "species_2066763", "CHEBI:53487", "CHEBI:53486", "species_8934421", "CHEBI:53488", "CHEBI:28661", "CHEBI:28364", "CHEBI:27432", "O17899", "WBGene00010329", "species_158602", "species_419777", "P90745", "WBGene00007006", "species_209794", "species_209789", "G5EBX8", "WBGene00008890", "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196", "species_29438", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "Q20325", "WBGene00018344", "Q9XUK8", "WBGene00012275", "P91096", "WBGene00016037", "Q18701", "WBGene00016747", "O17239", "WBGene00019616", "Q18130", "WBGene00016044", "G5EG10", "WBGene00003233", "A0A3B1DQQ4", "WBGene00006864", "H9G358", "WBGene00018089", "P34311", "WBGene00018089", "Q09502", "WBGene00008065", "Q20841", "WBGene00018886", "Q23033", "WBGene00020086", "A0A0K3AXD3", "WBGene00011372", "Q9XVQ0", "WBGene00018089", "A0A2C9C3A4", "WBGene00018089", "G5EDI0", "WBGene00007395", "O62403", "WBGene00013782", "Q9U7D5", "WBGene00001519", "Q03566", "WBGene00006576", "Q95YD7", "WBGene00016265", "H2KZ99", "WBGene00016570", "O17899", "WBGene00010329", "G5EBX8", "WBGene00008890", "P90745", "WBGene00007006", "O44731", "WBGene00018798", "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196", "species_29438", "species_74016", "species_113582", "species_419777", "species_29358", "species_113552", "species_70106", "species_216785", "species_380585", "CHEBI:28716", "species_390435", "CHEBI:28875", "CHEBI:53460", "CHEBI:27997", "CHEBI:16196", "species_2066763", "CHEBI:53487", "CHEBI:53486", "species_8934421", "CHEBI:53488", "CHEBI:28661", "CHEBI:28364", "CHEBI:27432", "species_29444", "species_29468", "species_29498", "species_417891", "species_209794", "species_209789", "species_158602", "species_8869214", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "A9Z1L1", "WBGene00005648", "G5ECY2", "WBGene00005644", "species_29460", "CHEBI:31011", "CHEBI:30772", "species_427486", "CHEBI:30768", "CHEBI:50122", "species_33549", "CHEBI:42504", "CHEBI:6498", "Q10651", "WBGene00000149", "species_372533", "species_266074", "species_266013", "CHEBI:15650", "species_266056", "CHEBI:17120", "species_209849", "species_390899", "CHEBI:15627", "species_879535", "species_265287" ] }, "reaction_10521878": { "compartment": "compartment_876", "id": "reaction_10521878", "reactome": "R-CEL-418582", "name": "G alpha (q) auto-inactivates by hydrolysing GTP to GDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508937" ], "products": [ "species_10509557" ], "modifiers": [ [ "species_10508937", "catalyst" ], [ "species_10521876", "catalyst" ] ], "additional_components": [ "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196", "species_29438", "species_29420", "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196", "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196", "species_29438", "P49808", "WBGene00004345", "Q18563", "WBGene00004349", "G5ECK9", "WBGene00004351", "Q23376", "WBGene00004352", "O45523", "WBGene00004353", "Q8WQC0", "WBGene00004350", "O45524", "WBGene00004354", "A0A5S9MNH1", "WBGene00004347" ] }, "reaction_10521559": { "compartment": "compartment_70101", "id": "reaction_10521559", "reactome": "R-CEL-416358", "name": "G alpha (q) inhibits PI3K alpha", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10506892", "species_10508937" ], "products": [ "species_10521557" ], "modifiers": [], "additional_components": [ "G5EDP9", "WBGene00000001", "Q94125", "WBGene00000090", "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196", "species_29438", "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196", "species_29438", "G5EDP9", "WBGene00000001", "Q94125", "WBGene00000090" ] }, "reaction_10509655": { "compartment": "compartment_876", "id": "reaction_10509655", "reactome": "R-CEL-114688", "name": "PLC-beta hydrolyses PIP2 to DAG and IP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509650" ], "products": [ "species_10509652" ], "modifiers": [ [ "species_10508939", "catalyst" ] ], "additional_components": [ "species_179856", "G5EBH0", "WBGene00001177", "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196", "species_29438", "species_114519", "species_114520", "G5EBH0", "WBGene00001177", "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196", "species_29438", "G5EBH0", "WBGene00001177", "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196", "species_29438" ] }, "reaction_10521563": { "compartment": "compartment_876", "id": "reaction_10521563", "reactome": "R-CEL-416516", "name": "GRK2 sequesters activated Gq", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509037", "species_10508937" ], "products": [ "species_10521561" ], "modifiers": [], "additional_components": [ "WBGene00001709", "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196", "species_29438", "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196", "species_29438", "Q09639", "WBGene00001709" ] }, "reaction_10528032": { "compartment": "compartment_876", "id": "reaction_10528032", "reactome": "R-CEL-750988", "name": "Inactive G alpha (z) reassociates with G beta:gamma", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10527902", "species_10509165" ], "products": [ "species_10527904" ], "modifiers": [], "additional_components": [ "O76584", "WBGene00001673", "P91907", "WBGene00001677", "Q20907", "WBGene00001670", "Q20910", "WBGene00001671", "Q21917", "WBGene00001669", "Q93743", "WBGene00001668", "Q9BIG2", "WBGene00001676", "species_29420", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "O76584", "WBGene00001673", "P91907", "WBGene00001677", "Q20907", "WBGene00001670", "Q20910", "WBGene00001671", "Q21917", "WBGene00001669", "Q93743", "WBGene00001668", "Q9BIG2", "WBGene00001676", "species_29420" ] }, "reaction_10570482": { "compartment": "compartment_876", "id": "reaction_10570482", "reactome": "R-CEL-8982018", "name": "G alpha (z):RGS complex dissociates to give inactive G alpha (z)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10570480" ], "products": [ "species_10527902", "species_10570434" ], "modifiers": [], "additional_components": [ "O76584", "WBGene00001673", "P91907", "WBGene00001677", "Q20907", "WBGene00001670", "Q20910", "WBGene00001671", "Q21917", "WBGene00001669", "Q93743", "WBGene00001668", "Q9BIG2", "WBGene00001676", "Q8WQC0", "WBGene00004350", "G5ECK9", "WBGene00004351", "O45523", "WBGene00004353", "O45524", "WBGene00004354", "Q18563", "WBGene00004349", "Q23376", "WBGene00004352", "species_29420", "O76584", "WBGene00001673", "P91907", "WBGene00001677", "Q20907", "WBGene00001670", "Q20910", "WBGene00001671", "Q21917", "WBGene00001669", "Q93743", "WBGene00001668", "Q9BIG2", "WBGene00001676", "species_29420", "Q8WQC0", "WBGene00004350", "G5ECK9", "WBGene00004351", "O45523", "WBGene00004353", "O45524", "WBGene00004354", "Q18563", "WBGene00004349", "Q23376", "WBGene00004352" ] }, "reaction_10527908": { "compartment": "compartment_876", "id": "reaction_10527908", "reactome": "R-CEL-749446", "name": "Liganded Gz-activating GPCRs bind inactive heterotrimeric G-protein Gz", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10519749", "species_10527904" ], "products": [ "species_10527906" ], "modifiers": [], "additional_components": [ "O02213", "WBGene00004777", "Q19084", "WBGene00017157", "species_209794", "species_209789", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "O76584", "WBGene00001673", "P91907", "WBGene00001677", "Q20907", "WBGene00001670", "Q20910", "WBGene00001671", "Q21917", "WBGene00001669", "Q93743", "WBGene00001668", "Q9BIG2", "WBGene00001676", "species_29420", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "O76584", "WBGene00001673", "P91907", "WBGene00001677", "Q20907", "WBGene00001670", "Q20910", "WBGene00001671", "Q21917", "WBGene00001669", "Q93743", "WBGene00001668", "Q9BIG2", "WBGene00001676", "species_29420", "O02213", "WBGene00004777", "Q19084", "WBGene00017157", "species_209794", "species_209789" ] }, "reaction_10521015": { "compartment": "compartment_876", "id": "reaction_10521015", "reactome": "R-CEL-392064", "name": "G alpha (z) inhibits adenylate cyclase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10521011", "species_10508992" ], "products": [ "species_10521013" ], "modifiers": [], "additional_components": [ "O76584", "WBGene00001673", "P91907", "WBGene00001677", "Q20907", "WBGene00001670", "Q20910", "WBGene00001671", "Q21917", "WBGene00001669", "Q93743", "WBGene00001668", "Q9BIG2", "WBGene00001676", "species_29438", "species_114632", "Q19523", "WBGene00000068", "O16880", "WBGene00000069", "G5EE33", "WBGene00000070", "Q966F9", "WBGene00000071", "species_114632", "Q19523", "WBGene00000068", "O16880", "WBGene00000069", "G5EE33", "WBGene00000070", "Q966F9", "WBGene00000071", "O76584", "WBGene00001673", "P91907", "WBGene00001677", "Q20907", "WBGene00001670", "Q20910", "WBGene00001671", "Q21917", "WBGene00001669", "Q93743", "WBGene00001668", "Q9BIG2", "WBGene00001676", "species_29438" ] }, "reaction_10570438": { "compartment": "compartment_876", "id": "reaction_10570438", "reactome": "R-CEL-8981892", "name": "Active G alpha (z) binds RGS proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10570434", "species_10521011" ], "products": [ "species_10570436" ], "modifiers": [], "additional_components": [ "Q8WQC0", "WBGene00004350", "G5ECK9", "WBGene00004351", "O45523", "WBGene00004353", "O45524", "WBGene00004354", "Q18563", "WBGene00004349", "Q23376", "WBGene00004352", "O76584", "WBGene00001673", "P91907", "WBGene00001677", "Q20907", "WBGene00001670", "Q20910", "WBGene00001671", "Q21917", "WBGene00001669", "Q93743", "WBGene00001668", "Q9BIG2", "WBGene00001676", "species_29438", "O76584", "WBGene00001673", "P91907", "WBGene00001677", "Q20907", "WBGene00001670", "Q20910", "WBGene00001671", "Q21917", "WBGene00001669", "Q93743", "WBGene00001668", "Q9BIG2", "WBGene00001676", "species_29438", "Q8WQC0", "WBGene00004350", "G5ECK9", "WBGene00004351", "O45523", "WBGene00004353", "O45524", "WBGene00004354", "Q18563", "WBGene00004349", "Q23376", "WBGene00004352" ] }, "reaction_10528026": { "compartment": "compartment_70101", "id": "reaction_10528026", "reactome": "R-CEL-749453", "name": "Liganded Gz-activating GPCR acts as a GEF for Gz", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10527906" ], "products": [ "species_29420", "species_10528023" ], "modifiers": [ [ "species_10527906", "catalyst" ] ], "additional_components": [ "P17343", "WBGene00001679", "P54406", "WBGene00001681", "O76584", "WBGene00001673", "P91907", "WBGene00001677", "Q20907", "WBGene00001670", "Q20910", "WBGene00001671", "Q21917", "WBGene00001669", "Q93743", "WBGene00001668", "Q9BIG2", "WBGene00001676", "species_29420", "O02213", "WBGene00004777", "Q19084", "WBGene00017157", "species_209794", "species_209789", "O76584", "WBGene00001673", "P91907", "WBGene00001677", "Q20907", "WBGene00001670", "Q20910", "WBGene00001671", "Q21917", "WBGene00001669", "Q93743", "WBGene00001668", "Q9BIG2", "WBGene00001676", "species_29438", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "O02213", "WBGene00004777", "Q19084", "WBGene00017157", "species_209794", "species_209789", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "O76584", "WBGene00001673", "P91907", "WBGene00001677", "Q20907", "WBGene00001670", "Q20910", "WBGene00001671", "Q21917", "WBGene00001669", "Q93743", "WBGene00001668", "Q9BIG2", "WBGene00001676", "species_29420", "O02213", "WBGene00004777", "Q19084", "WBGene00017157", "species_209794", "species_209789" ] }, "reaction_10528042": { "compartment": "compartment_984", "id": "reaction_10528042", "reactome": "R-CEL-751024", "name": "The Ligand:GPCR:Gz complex dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10528023" ], "products": [ "species_10509165", "species_390627", "species_10519747", "species_10521011" ], "modifiers": [], "additional_components": [ "O76584", "WBGene00001673", "P91907", "WBGene00001677", "Q20907", "WBGene00001670", "Q20910", "WBGene00001671", "Q21917", "WBGene00001669", "Q93743", "WBGene00001668", "Q9BIG2", "WBGene00001676", "species_29438", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "O02213", "WBGene00004777", "Q19084", "WBGene00017157", "species_209794", "species_209789", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "species_209794", "species_209789", "O02213", "WBGene00004777", "Q19084", "WBGene00017157", "O76584", "WBGene00001673", "P91907", "WBGene00001677", "Q20907", "WBGene00001670", "Q20910", "WBGene00001671", "Q21917", "WBGene00001669", "Q93743", "WBGene00001668", "Q9BIG2", "WBGene00001676", "species_29438" ] }, "reaction_10570492": { "compartment": "compartment_876", "id": "reaction_10570492", "reactome": "R-CEL-8982021", "name": "G alpha (z) in G alpha (z):RGS complex is inactivated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10570436" ], "products": [ "species_29372", "species_10570480" ], "modifiers": [ [ "species_10570436", "catalyst" ] ], "additional_components": [ "O76584", "WBGene00001673", "P91907", "WBGene00001677", "Q20907", "WBGene00001670", "Q20910", "WBGene00001671", "Q21917", "WBGene00001669", "Q93743", "WBGene00001668", "Q9BIG2", "WBGene00001676", "species_29438", "Q8WQC0", "WBGene00004350", "G5ECK9", "WBGene00004351", "O45523", "WBGene00004353", "O45524", "WBGene00004354", "Q18563", "WBGene00004349", "Q23376", "WBGene00004352", "O76584", "WBGene00001673", "P91907", "WBGene00001677", "Q20907", "WBGene00001670", "Q20910", "WBGene00001671", "Q21917", "WBGene00001669", "Q93743", "WBGene00001668", "Q9BIG2", "WBGene00001676", "Q8WQC0", "WBGene00004350", "G5ECK9", "WBGene00004351", "O45523", "WBGene00004353", "O45524", "WBGene00004354", "Q18563", "WBGene00004349", "Q23376", "WBGene00004352", "species_29420", "O76584", "WBGene00001673", "P91907", "WBGene00001677", "Q20907", "WBGene00001670", "Q20910", "WBGene00001671", "Q21917", "WBGene00001669", "Q93743", "WBGene00001668", "Q9BIG2", "WBGene00001676", "species_29438", "Q8WQC0", "WBGene00004350", "G5ECK9", "WBGene00004351", "O45523", "WBGene00004353", "O45524", "WBGene00004354", "Q18563", "WBGene00004349", "Q23376", "WBGene00004352" ] }, "reaction_10528049": { "compartment": "compartment_70101", "id": "reaction_10528049", "reactome": "R-CEL-751029", "name": "Liganded G12/13-activating GPCR acts as a GEF for G12/13", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10528044" ], "products": [ "species_29420", "species_10528038" ], "modifiers": [ [ "species_10528044", "catalyst" ] ], "additional_components": [ "species_29420", "Q19572", "WBGene00001674", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "species_209794", "species_209789", "G5EBX8", "WBGene00008890", "species_209794", "species_209789", "G5EBX8", "WBGene00008890", "Q19572", "WBGene00001674", "species_29438", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "species_29420", "Q19572", "WBGene00001674", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "species_209794", "species_209789", "G5EBX8", "WBGene00008890" ] }, "reaction_10509505": { "compartment": "compartment_70101", "id": "reaction_10509505", "reactome": "R-CEL-114544", "name": "p115-RhoGEF activation of RHOA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10509486" ], "products": [ "species_29420", "species_10509488" ], "modifiers": [ [ "species_10509502", "catalyst" ] ], "additional_components": [ "Q22038", "WBGene00004357", "species_29420", "Q22038", "WBGene00004357", "species_29438", "Q19572", "WBGene00001674", "species_29438", "G5EFE1", "WBGene00006468" ] }, "reaction_10521106": { "compartment": "compartment_876", "id": "reaction_10521106", "reactome": "R-CEL-398185", "name": "LARG binds plexin B1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10518605", "species_10521100" ], "products": [ "species_10521104" ], "modifiers": [], "additional_components": [ "O45657", "WBGene00004048", "U4PRY7", "WBGene00004047", "G5EFE1", "WBGene00006468", "H2L0P5", "WBGene00022391", "Q19572", "WBGene00001674", "species_29438", "G5EFE1", "WBGene00006468", "H2L0P5", "WBGene00022391", "Q19572", "WBGene00001674", "species_29438", "O45657", "WBGene00004048", "U4PRY7", "WBGene00004047" ] }, "reaction_10509507": { "compartment": "compartment_70101", "id": "reaction_10509507", "reactome": "R-CEL-114548", "name": "G alpha (13) activates Rho guanine nucleotide exchange factor 1 (p115-RhoGEF)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509500", "species_10509495" ], "products": [ "species_10509502" ], "modifiers": [], "additional_components": [ "WBGene00006468", "Q19572", "WBGene00001674", "species_29438", "Q19572", "WBGene00001674", "species_29438", "G5EFE1", "WBGene00006468" ] }, "reaction_10528051": { "compartment": "compartment_876", "id": "reaction_10528051", "reactome": "R-CEL-751039", "name": "Inactive G alpha (12/13) reassociates with G beta:gamma", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509165", "species_10521820" ], "products": [ "species_10509524" ], "modifiers": [], "additional_components": [ "P17343", "WBGene00001679", "P54406", "WBGene00001681", "species_29420", "Q19572", "WBGene00001674", "species_29420", "Q19572", "WBGene00001674", "P17343", "WBGene00001679", "P54406", "WBGene00001681" ] }, "reaction_10521958": { "compartment": "compartment_70101", "id": "reaction_10521958", "reactome": "R-CEL-419166", "name": "GEFs activate RhoA,B,C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10521599", "species_29438" ], "products": [ "species_29420", "species_10509488" ], "modifiers": [ [ "species_10516176", "catalyst" ] ], "additional_components": [ "species_29420", "Q22038", "WBGene00004357", "Q22038", "WBGene00004357", "species_29438", "G5EFE1", "WBGene00006468", "H2L0P5", "WBGene00022391", "G5EF62", "WBGene00009337", "Q9U3P2", "WBGene00007750", "X5LV34", "WBGene00001366", "S6EZU2", "WBGene00006476", "Q45FX5", "WBGene00006887", "Q21653", "WBGene00019832", "A0A0K3AQN0", "WBGene00013682", "O01847", "WBGene00015704", "Q965J0", "WBGene00019487", "Q21430", "WBGene00010776", "H2KYI7", "WBGene00006496", "Q9N5D3", "WBGene00004947", "Q9U364", "WBGene00002297", "A0A0K3AS36", "Y116A8C.36d", "Q19572", "WBGene00001674", "species_29438" ] }, "reaction_10528040": { "compartment": "compartment_984", "id": "reaction_10528040", "reactome": "R-CEL-751019", "name": "The Ligand:GPCR:G12/13 complex dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10528038" ], "products": [ "species_10509165", "species_10521096", "species_10519575", "species_791498" ], "modifiers": [], "additional_components": [ "species_209794", "species_209789", "G5EBX8", "WBGene00008890", "Q19572", "WBGene00001674", "species_29438", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "Q19572", "WBGene00001674", "species_29438", "WBGene00008890", "species_209794", "species_209789", "CHEBI:15627" ] }, "reaction_10528046": { "compartment": "compartment_876", "id": "reaction_10528046", "reactome": "R-CEL-751027", "name": "Liganded G12/13-activating GPCRs bind inactive heterotrimeric G-protein G12/13", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10519581", "species_10509524" ], "products": [ "species_10528044" ], "modifiers": [], "additional_components": [ "species_209794", "species_209789", "G5EBX8", "WBGene00008890", "species_29420", "Q19572", "WBGene00001674", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "species_29420", "Q19572", "WBGene00001674", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "species_209794", "species_209789", "G5EBX8", "WBGene00008890" ] }, "reaction_10521102": { "compartment": "compartment_70101", "id": "reaction_10521102", "reactome": "R-CEL-398184", "name": "LARG activation by G alpha 12/13", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10521096", "species_10516134" ], "products": [ "species_10521100" ], "modifiers": [], "additional_components": [ "Q19572", "WBGene00001674", "species_29438", "G5EFE1", "WBGene00006468", "H2L0P5", "WBGene00022391", "G5EFE1", "WBGene00006468", "H2L0P5", "WBGene00022391", "Q19572", "WBGene00001674", "species_29438" ] }, "reaction_10521823": { "compartment": "compartment_876", "id": "reaction_10521823", "reactome": "R-CEL-418574", "name": "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10521096" ], "products": [ "species_10521820" ], "modifiers": [ [ "species_10521096", "catalyst" ] ], "additional_components": [ "Q19572", "WBGene00001674", "species_29438", "species_29420", "Q19572", "WBGene00001674", "Q19572", "WBGene00001674", "species_29438" ] }, "reaction_10528246": { "compartment": "compartment_876", "id": "reaction_10528246", "reactome": "R-CEL-879674", "name": "CD97 binds CD55", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10528242", "species_10524688" ], "products": [ "species_10528244" ], "modifiers": [], "additional_components": [ "Q22328", "WBGene00002976", "A0A1N7SYP5", "WBGene00009500", "Q18849", "WBGene00009500", "WBGene00002252", "G5ECX0", "WBGene00002252", "Q22328", "WBGene00002976", "A0A1N7SYP5", "WBGene00009500", "Q18849", "WBGene00009500" ] }, "reaction_10524696": { "compartment": "compartment_984", "id": "reaction_10524696", "reactome": "R-CEL-444773", "name": "EGF-TM7 receptors bind chondroitin sulphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_444761", "species_10524686" ], "products": [ "species_10524694" ], "modifiers": [], "additional_components": [ "WBGene00002252", "G5ECX0", "WBGene00002252", "species_444761" ] }, "reaction_10518464": { "compartment": "compartment_984", "id": "reaction_10518464", "reactome": "R-CEL-373075", "name": "Metabotropic glutamate receptors bind glutamate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_210382", "species_10518460" ], "products": [ "species_10518462" ], "modifiers": [], "additional_components": [ "G5EG10", "WBGene00003233", "A1IMB8", "WBGene00021152", "Q09630", "WBGene00003232", "G5EG10", "WBGene00003233", "A1IMB8", "WBGene00021152", "Q09630", "WBGene00003232", "species_113552" ] }, "reaction_10522001": { "compartment": "compartment_876", "id": "reaction_10522001", "reactome": "R-CEL-420688", "name": "GABAB heterodimeric receptor binds GABA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352003", "species_10519829" ], "products": [ "species_10519831" ], "modifiers": [], "additional_components": [ "G5ECB2", "WBGene00022675", "H2L0Q3", "WBGene00021528", "G5ECB2", "WBGene00022675", "H2L0Q3", "WBGene00021528", "species_352003" ] }, "reaction_10524672": { "compartment": "compartment_984", "id": "reaction_10524672", "reactome": "R-CEL-444654", "name": "G-protein coupled bile acid receptor binds lithocholic acid", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_444840", "species_10524668" ], "products": [ "species_10524670" ], "modifiers": [], "additional_components": [ "species_5357505", "species_193451", "species_176655", "CHEBI:16755", "Q10042", "WBGene00019287", "Q19295", "WBGene00019287", "Q19779", "WBGene00017779", "Q1ZXT2", "WBGene00011878", "Q10042", "WBGene00019287", "Q19295", "WBGene00019287", "Q19779", "WBGene00017779", "Q1ZXT2", "WBGene00011878", "species_5357505", "species_193451", "species_176655", "CHEBI:16755" ] }, "reaction_10563088": { "compartment": "compartment_984", "id": "reaction_10563088", "reactome": "R-CEL-6805205", "name": "GPR35 binds kynurenic acid", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10563084", "species_6805204" ], "products": [ "species_10563086" ], "modifiers": [], "additional_components": [ "WBGene00016570", "species_6805204", "H2KZ99", "WBGene00016570" ] }, "reaction_10520929": { "compartment": "compartment_984", "id": "reaction_10520929", "reactome": "R-CEL-391934", "name": "DP2 receptor can bind PGD2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_416911", "species_10519813" ], "products": [ "species_10519815" ], "modifiers": [], "additional_components": [ "Q23033", "WBGene00020086", "A0A0K3AXD3", "WBGene00011372", "Q9XVQ0", "WBGene00018089", "A0A2C9C3A4", "WBGene00018089", "A0A3B1DQQ4", "WBGene00006864", "H9G358", "WBGene00018089", "P34311", "WBGene00018089", "Q09502", "WBGene00008065", "Q20841", "WBGene00018886", "Q23033", "WBGene00020086", "A0A0K3AXD3", "WBGene00011372", "Q9XVQ0", "WBGene00018089", "A0A2C9C3A4", "WBGene00018089", "A0A3B1DQQ4", "WBGene00006864", "H9G358", "WBGene00018089", "P34311", "WBGene00018089", "Q09502", "WBGene00008065", "Q20841", "WBGene00018886", "species_879629" ] }, "reaction_10520931": { "compartment": "compartment_984", "id": "reaction_10520931", "reactome": "R-CEL-391937", "name": "UDP/CysLT receptor can bind cysteinyl leukotrienes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10519635", "species_416372" ], "products": [ "species_10519793" ], "modifiers": [], "additional_components": [ "WBGene00016570", "species_266074", "species_266013", "CHEBI:15650", "species_266074", "species_266013", "CHEBI:15650", "H2KZ99", "WBGene00016570" ] }, "reaction_10520933": { "compartment": "compartment_984", "id": "reaction_10520933", "reactome": "R-CEL-391941", "name": "BLT receptors can bind LTB4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10519651", "species_416436" ], "products": [ "species_10519653" ], "modifiers": [], "additional_components": [ "Q20325", "WBGene00018344", "Q9XUK8", "WBGene00012275", "species_266056", "Q20325", "WBGene00018344", "Q9XUK8", "WBGene00012275" ] }, "reaction_10520935": { "compartment": "compartment_984", "id": "reaction_10520935", "reactome": "R-CEL-391943", "name": "CYSLT2 binds LTC4,LTD4,LTE4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10519631", "species_416372" ], "products": [ "species_10519633" ], "modifiers": [], "additional_components": [ "Q20325", "WBGene00018344", "Q9XUK8", "WBGene00012275", "species_266074", "species_266013", "CHEBI:15650", "species_266074", "species_266013", "CHEBI:15650", "Q20325", "WBGene00018344", "Q9XUK8", "WBGene00012275" ] }, "reaction_10573113": { "compartment": "compartment_984", "id": "reaction_10573113", "reactome": "R-CEL-9684627", "name": "CYSLTR1 binds CYSLTR1 antagonists", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10519623", "species_9684615" ], "products": [ "species_10573111" ], "modifiers": [], "additional_components": [ "Q20325", "WBGene00018344", "Q9XUK8", "WBGene00012275", "Q20325", "WBGene00018344", "Q9XUK8", "WBGene00012275" ] }, "reaction_10573117": { "compartment": "compartment_984", "id": "reaction_10573117", "reactome": "R-CEL-9690439", "name": "CYSLTR1 binds LTC4,LTD4,LTE4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10519623", "species_416372" ], "products": [ "species_10519625" ], "modifiers": [ [ "species_10573111", "inhibitor" ] ], "additional_components": [ "Q20325", "WBGene00018344", "Q9XUK8", "WBGene00012275", "species_266074", "species_266013", "CHEBI:15650", "species_266074", "species_266013", "CHEBI:15650", "Q20325", "WBGene00018344", "Q9XUK8", "WBGene00012275", "Q20325", "WBGene00018344", "Q9XUK8", "WBGene00012275" ] }, "reaction_10521905": { "compartment": "compartment_984", "id": "reaction_10521905", "reactome": "R-CEL-418918", "name": "The UDP/CysLT (P2Y17) receptor can bind UTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_417888", "species_10519635" ], "products": [ "species_10519637" ], "modifiers": [], "additional_components": [ "WBGene00016570", "H2KZ99", "WBGene00016570", "species_158602" ] }, "reaction_10521699": { "compartment": "compartment_984", "id": "reaction_10521699", "reactome": "R-CEL-417820", "name": "P2Y9 receptor can bind to LPA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10519598", "species_417891" ], "products": [ "species_10519600" ], "modifiers": [], "additional_components": [ "WBGene00016570", "species_417891", "H2KZ99", "WBGene00016570" ] }, "reaction_10521701": { "compartment": "compartment_984", "id": "reaction_10521701", "reactome": "R-CEL-417842", "name": "P2Y10 receptor can bind to LPA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_417891", "species_10519602" ], "products": [ "species_10519604" ], "modifiers": [], "additional_components": [ "WBGene00016570", "H2KZ99", "WBGene00016570", "species_417891" ] }, "reaction_10521703": { "compartment": "compartment_984", "id": "reaction_10521703", "reactome": "R-CEL-417890", "name": "P2Y5 receptor can bind to LPA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10519594", "species_417891" ], "products": [ "species_10519596" ], "modifiers": [], "additional_components": [ "WBGene00016570", "species_417891", "H2KZ99", "WBGene00016570" ] }, "reaction_10521923": { "compartment": "compartment_984", "id": "reaction_10521923", "reactome": "R-CEL-418925", "name": "ADORA2A,B bind Ade-Rib", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10521919", "species_83908" ], "products": [ "species_10521921" ], "modifiers": [], "additional_components": [ "Q10042", "WBGene00019287", "Q19295", "WBGene00019287", "Q19779", "WBGene00017779", "Q1ZXT2", "WBGene00011878", "species_83909", "Q10042", "WBGene00019287", "Q19295", "WBGene00019287", "Q19779", "WBGene00017779", "Q1ZXT2", "WBGene00011878" ] }, "reaction_10521903": { "compartment": "compartment_984", "id": "reaction_10521903", "reactome": "R-CEL-418904", "name": "A1 and A3 receptors bind adenosine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10519789", "species_83908" ], "products": [ "species_10519791" ], "modifiers": [], "additional_components": [ "Q10042", "WBGene00019287", "Q19295", "WBGene00019287", "Q19779", "WBGene00017779", "Q1ZXT2", "WBGene00011878", "species_83909", "Q10042", "WBGene00019287", "Q19295", "WBGene00019287", "Q19779", "WBGene00017779", "Q1ZXT2", "WBGene00011878" ] }, "reaction_10524681": { "compartment": "compartment_984", "id": "reaction_10524681", "reactome": "R-CEL-444731", "name": "GPR4, GPR65, GPR132 and OGR1 are pH sensing receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_10519655" ], "products": [ "species_10519659" ], "modifiers": [], "additional_components": [ "WBGene00016570", "H2KZ99", "WBGene00016570", "species_70106" ] }, "reaction_10521965": { "compartment": "compartment_984", "id": "reaction_10521965", "reactome": "R-CEL-419861", "name": "Melanospin is stimulated by light", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10519609", "species_419777" ], "products": [ "species_10519611" ], "modifiers": [], "additional_components": [ "WBGene00007006", "species_419777", "P90745", "WBGene00007006" ] }, "reaction_10520833": { "compartment": "compartment_984", "id": "reaction_10520833", "reactome": "R-CEL-390673", "name": "CHRM2,4 bind acetylcholine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10519751", "species_372533" ], "products": [ "species_10519755" ], "modifiers": [], "additional_components": [ "WBGene00001519", "species_372533", "Q9U7D5", "WBGene00001519" ] }, "reaction_10520829": { "compartment": "compartment_984", "id": "reaction_10520829", "reactome": "R-CEL-390649", "name": "CHRM1,3,5 bind acetylcholine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10519564", "species_372533" ], "products": [ "species_10519570" ], "modifiers": [], "additional_components": [ "WBGene00001519", "species_372533", "Q9U7D5", "WBGene00001519" ] }, "reaction_10572915": { "compartment": "compartment_984", "id": "reaction_10572915", "reactome": "R-CEL-9656244", "name": "DRD2 binds DA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10572911", "species_380873" ], "products": [ "species_10572913" ], "modifiers": [], "additional_components": [ "WBGene00020506", "species_351601", "Q6RYS9", "WBGene00020506" ] }, "reaction_10520835": { "compartment": "compartment_984", "id": "reaction_10520835", "reactome": "R-CEL-390846", "name": "D2D3,4 bind to DA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10519725", "species_380873" ], "products": [ "species_10519727" ], "modifiers": [], "additional_components": [ "Q6RYS9", "WBGene00020506", "E7EM37", "WBGene00001053", "G5EGH0", "WBGene00004779", "species_351601", "Q6RYS9", "WBGene00020506", "E7EM37", "WBGene00001053", "G5EGH0", "WBGene00004779" ] }, "reaction_10520837": { "compartment": "compartment_984", "id": "reaction_10520837", "reactome": "R-CEL-390886", "name": "HRH4 binds Hist", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10519710", "species_390899" ], "products": [ "species_10519712" ], "modifiers": [], "additional_components": [ "WBGene00001519", "species_390899", "Q9U7D5", "WBGene00001519" ] }, "reaction_10520846": { "compartment": "compartment_984", "id": "reaction_10520846", "reactome": "R-CEL-390909", "name": "HRH2 binds hist", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10520842", "species_390899" ], "products": [ "species_10520844" ], "modifiers": [], "additional_components": [ "WBGene00011382", "species_390899", "O45732", "WBGene00011382" ] }, "reaction_10573135": { "compartment": "compartment_984", "id": "reaction_10573135", "reactome": "R-CEL-9692880", "name": "HRH3 binds Hist", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10573131", "species_390899" ], "products": [ "species_10573133" ], "modifiers": [], "additional_components": [ "WBGene00001519", "species_390899", "Q9U7D5", "WBGene00001519" ] }, "reaction_10520848": { "compartment": "compartment_984", "id": "reaction_10520848", "reactome": "R-CEL-390929", "name": "HTR1 and 5A receptors can bind serotonin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_114523", "species_10519706" ], "products": [ "species_10519708" ], "modifiers": [], "additional_components": [ "Q7JP61", "WBGene00006411", "E7EM37", "WBGene00001053", "G5EGH0", "WBGene00004779", "Q7JP61", "WBGene00006411", "E7EM37", "WBGene00001053", "G5EGH0", "WBGene00004779", "species_380585" ] }, "reaction_10520865": { "compartment": "compartment_984", "id": "reaction_10520865", "reactome": "R-CEL-390931", "name": "5-HT4, 6 and 7 receptors can bind serotonin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10520861", "species_114523" ], "products": [ "species_10520863" ], "modifiers": [], "additional_components": [ "O45732", "WBGene00011382", "Q86ME6", "WBGene00001052", "Q22895", "WBGene00004780", "species_380585", "O45732", "WBGene00011382", "Q86ME6", "WBGene00001052", "Q22895", "WBGene00004780" ] }, "reaction_10520850": { "compartment": "compartment_984", "id": "reaction_10520850", "reactome": "R-CEL-390930", "name": "5-HT2 receptor can bind serotonin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_114523", "species_10519586" ], "products": [ "species_10519592" ], "modifiers": [], "additional_components": [ "WBGene00016037", "P91096", "WBGene00016037", "species_380585" ] }, "reaction_10573212": { "compartment": "compartment_984", "id": "reaction_10573212", "reactome": "R-CEL-9693347", "name": "HTR1A binds 5HT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_114523", "species_10573208" ], "products": [ "species_10573210" ], "modifiers": [], "additional_components": [ "WBGene00004779", "G5EGH0", "WBGene00004779", "species_380585" ] }, "reaction_10555425": { "compartment": "compartment_70101", "id": "reaction_10555425", "reactome": "R-CEL-5681981", "name": "ATG3 transfers LC3 from ATG7 to ATG3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10555420" ], "products": [ "species_10555422" ], "modifiers": [ [ "species_10555420", "catalyst" ] ], "additional_components": [ "Q9N369", "WBGene00021922", "G5EBK4", "WBGene00010882", "Q23536", "WBGene00002981", "Q09490", "WBGene00002980", "Q9N369", "WBGene00021922", "Q23536", "WBGene00002981", "Q09490", "WBGene00002980", "G5EBK4", "WBGene00010882", "Q9N369", "WBGene00021922", "G5EBK4", "WBGene00010882", "Q23536", "WBGene00002981", "Q09490", "WBGene00002980" ] }, "reaction_10555489": { "compartment": "compartment_5683628", "id": "reaction_10555489", "reactome": "R-CEL-5682388", "name": "Autophagosome maturation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10555350" ], "products": [ "species_10555480" ], "modifiers": [ [ "species_10555487", "catalyst" ], [ "species_10529080", "catalyst" ] ], "additional_components": [ "species_8959490", "Q23536", "WBGene00002981", "Q09490", "WBGene00002980", "Q23536", "WBGene00002981", "Q09490", "WBGene00002980", "species_8959490", "Q9TXI7", "WBGene00006932", "Q22592", "WBGene00000247", "Q23669", "WBGene00014151", "A7DT33", "WBGene00021319", "Q9GYK4", "WBGene00020866", "Q9BL60", "WBGene00022027", "Q9U2F6", "WBGene00012903", "O02208", "WBGene00007216", "Q22718", "WBGene00011976", "Q18886", "WBGene00016961", "Q21959", "WBGene00020025" ] }, "reaction_10554859": { "compartment": "compartment_70101", "id": "reaction_10554859", "reactome": "R-CEL-5672008", "name": "Thr-180 of ULK1 is phosphorylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10554667", "species_113592" ], "products": [ "species_29370", "species_10554856" ], "modifiers": [ [ "species_10554667", "catalyst" ] ], "additional_components": [ "species_76577", "Q9XUY2", "WBGene00010115", "P45894", "WBGene00019801", "Q95ZQ4", "WBGene00020142", "A0A1T5HUK9", "WBGene00013732", "H2L0K0", "WBGene00020135", "O02168", "WBGene00020633", "Q9N501", "WBGene00021527", "Q22342", "WBGene00020334", "Q23023", "WBGene00006786", "Q95XH2", "WBGene00022078", "P34379", "WBGene00017045", "species_76577", "Q9XUY2", "WBGene00010115", "P45894", "WBGene00019801", "Q95ZQ4", "WBGene00020142", "A0A1T5HUK9", "WBGene00013732", "H2L0K0", "WBGene00020135", "O02168", "WBGene00020633", "Q9N501", "WBGene00021527", "Q22342", "WBGene00020334", "Q23023", "WBGene00006786", "Q95XH2", "WBGene00022078", "P34379", "WBGene00017045", "species_76577", "Q9XUY2", "WBGene00010115", "P45894", "WBGene00019801", "Q95ZQ4", "WBGene00020142", "A0A1T5HUK9", "WBGene00013732", "H2L0K0", "WBGene00020135", "O02168", "WBGene00020633", "Q9N501", "WBGene00021527", "Q22342", "WBGene00020334", "Q23023", "WBGene00006786", "Q95XH2", "WBGene00022078", "P34379", "WBGene00017045" ] }, "reaction_10571498": { "compartment": "compartment_70101", "id": "reaction_10571498", "reactome": "R-CEL-9020616", "name": "ATG12 forms a thioester bond with ATG7 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10555409" ], "products": [ "species_10555535" ], "modifiers": [], "additional_components": [ "Q10931", "WBGene00002982", "G5EBK4", "WBGene00010882", "Q10931", "WBGene00002982", "G5EBK4", "WBGene00010882" ] }, "reaction_10555247": { "compartment": "compartment_74700", "id": "reaction_10555247", "reactome": "R-CEL-5675790", "name": "MTORC1 dissociates from ULK complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10555091" ], "products": [ "species_10510623", "species_10554866" ], "modifiers": [], "additional_components": [ "Q22342", "WBGene00020334", "Q23023", "WBGene00006786", "Q95XH2", "WBGene00022078", "P34379", "WBGene00017045", "P34443", "WBGene00010038", "species_29438", "Q19425", "WBGene00008774", "species_29420", "G5EGB3", "WBGene00012497", "Q22743", "WBGene00006414", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "P91040", "WBGene00015697", "Q95Q95", "WBGene00002583", "Q68TI8", "WBGene00000911", "P34443", "WBGene00010038", "species_29438", "Q19425", "WBGene00008774", "species_29420", "G5EGB3", "WBGene00012497", "Q22743", "WBGene00006414", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "P91040", "WBGene00015697", "Q95Q95", "WBGene00002583", "Q68TI8", "WBGene00000911", "Q22342", "WBGene00020334", "Q23023", "WBGene00006786", "Q95XH2", "WBGene00022078", "P34379", "WBGene00017045" ] }, "reaction_10555567": { "compartment": "compartment_70101", "id": "reaction_10555567", "reactome": "R-CEL-5683593", "name": "ATG7:ATG3:LC3 dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10555422" ], "products": [ "species_10555407", "species_10555348" ], "modifiers": [], "additional_components": [ "Q9N369", "WBGene00021922", "Q23536", "WBGene00002981", "Q09490", "WBGene00002980", "G5EBK4", "WBGene00010882", "G5EBK4", "WBGene00010882", "Q9N369", "WBGene00021922", "Q23536", "WBGene00002981", "Q09490", "WBGene00002980" ] }, "reaction_10554670": { "compartment": "compartment_70101", "id": "reaction_10554670", "reactome": "R-CEL-5665868", "name": "AMPK (complex) phosphorylates ULK1 (complex)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10554661" ], "products": [ "species_29370", "species_10554667" ], "modifiers": [ [ "species_10554661", "catalyst" ] ], "additional_components": [ "Q22342", "WBGene00020334", "Q23023", "WBGene00006786", "Q95XH2", "WBGene00022078", "P34379", "WBGene00017045", "species_76577", "Q9XUY2", "WBGene00010115", "P45894", "WBGene00019801", "Q95ZQ4", "WBGene00020142", "A0A1T5HUK9", "WBGene00013732", "H2L0K0", "WBGene00020135", "O02168", "WBGene00020633", "Q9N501", "WBGene00021527", "species_76577", "Q9XUY2", "WBGene00010115", "P45894", "WBGene00019801", "Q95ZQ4", "WBGene00020142", "A0A1T5HUK9", "WBGene00013732", "H2L0K0", "WBGene00020135", "O02168", "WBGene00020633", "Q9N501", "WBGene00021527", "Q22342", "WBGene00020334", "Q23023", "WBGene00006786", "Q95XH2", "WBGene00022078", "P34379", "WBGene00017045", "Q22342", "WBGene00020334", "Q23023", "WBGene00006786", "Q95XH2", "WBGene00022078", "P34379", "WBGene00017045", "species_76577", "Q9XUY2", "WBGene00010115", "P45894", "WBGene00019801", "Q95ZQ4", "WBGene00020142", "A0A1T5HUK9", "WBGene00013732", "H2L0K0", "WBGene00020135", "O02168", "WBGene00020633", "Q9N501", "WBGene00021527" ] }, "reaction_10555380": { "compartment": "compartment_70101", "id": "reaction_10555380", "reactome": "R-CEL-5678490", "name": "ATG16L1 complex transfers LC3 from ATG3 to PE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5681998", "species_10555348" ], "products": [ "species_10555352", "species_10555350" ], "modifiers": [ [ "species_10555377", "catalyst" ] ], "additional_components": [ "Q9N369", "WBGene00021922", "Q23536", "WBGene00002981", "Q09490", "WBGene00002980", "WBGene00021922", "species_8959490", "Q23536", "WBGene00002981", "Q09490", "WBGene00002980", "Q19124", "WBGene00017178", "Q09406", "WBGene00019427", "Q10931", "WBGene00002982", "Q3V5I7", "WBGene00022152", "O16466", "WBGene00018294", "species_5334668" ] }, "reaction_10554871": { "compartment": "compartment_17938", "id": "reaction_10554871", "reactome": "R-CEL-5672010", "name": "Active MTORC1 phosphorylates ULK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10554861", "species_113592" ], "products": [ "species_29370", "species_10554868" ], "modifiers": [ [ "species_10554861", "catalyst" ] ], "additional_components": [ "Q22342", "WBGene00020334", "Q23023", "WBGene00006786", "Q95XH2", "WBGene00022078", "P34379", "WBGene00017045", "Q19425", "WBGene00008774", "species_29420", "G5EGB3", "WBGene00012497", "Q22743", "WBGene00006414", "species_29438", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "P91040", "WBGene00015697", "Q95Q95", "WBGene00002583", "Q68TI8", "WBGene00000911", "P34443", "WBGene00010038", "Q22342", "WBGene00020334", "Q23023", "WBGene00006786", "Q95XH2", "WBGene00022078", "P34379", "WBGene00017045", "Q19425", "WBGene00008774", "species_29420", "G5EGB3", "WBGene00012497", "Q22743", "WBGene00006414", "species_29438", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "P91040", "WBGene00015697", "Q95Q95", "WBGene00002583", "Q68TI8", "WBGene00000911", "P34443", "WBGene00010038", "Q22342", "WBGene00020334", "Q23023", "WBGene00006786", "Q95XH2", "WBGene00022078", "P34379", "WBGene00017045", "Q19425", "WBGene00008774", "species_29420", "G5EGB3", "WBGene00012497", "Q22743", "WBGene00006414", "species_29438", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "P91040", "WBGene00015697", "Q95Q95", "WBGene00002583", "Q68TI8", "WBGene00000911", "P34443", "WBGene00010038" ] }, "reaction_10554873": { "compartment": "compartment_70101", "id": "reaction_10554873", "reactome": "R-CEL-5672011", "name": "p-AMPK:AMP binds the ULK complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10554659", "species_10519954" ], "products": [ "species_10554661" ], "modifiers": [], "additional_components": [ "Q22342", "WBGene00020334", "Q23023", "WBGene00006786", "Q95XH2", "WBGene00022078", "P34379", "WBGene00017045", "species_76577", "Q9XUY2", "WBGene00010115", "P45894", "WBGene00019801", "Q95ZQ4", "WBGene00020142", "A0A1T5HUK9", "WBGene00013732", "H2L0K0", "WBGene00020135", "O02168", "WBGene00020633", "Q9N501", "WBGene00021527", "Q22342", "WBGene00020334", "Q23023", "WBGene00006786", "Q95XH2", "WBGene00022078", "P34379", "WBGene00017045", "species_76577", "Q9XUY2", "WBGene00010115", "P45894", "WBGene00019801", "Q95ZQ4", "WBGene00020142", "A0A1T5HUK9", "WBGene00013732", "H2L0K0", "WBGene00020135", "O02168", "WBGene00020633", "Q9N501", "WBGene00021527" ] }, "reaction_10555259": { "compartment": "compartment_70101", "id": "reaction_10555259", "reactome": "R-CEL-5675868", "name": "ULK1 phosphorylates ATG13 and RB1CC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10554856" ], "products": [ "species_29370", "species_10555256" ], "modifiers": [ [ "species_10554856", "catalyst" ] ], "additional_components": [ "species_76577", "Q9XUY2", "WBGene00010115", "P45894", "WBGene00019801", "Q95ZQ4", "WBGene00020142", "A0A1T5HUK9", "WBGene00013732", "H2L0K0", "WBGene00020135", "O02168", "WBGene00020633", "Q9N501", "WBGene00021527", "Q22342", "WBGene00020334", "Q23023", "WBGene00006786", "Q95XH2", "WBGene00022078", "P34379", "WBGene00017045", "species_76577", "Q9XUY2", "WBGene00010115", "P45894", "WBGene00019801", "Q95ZQ4", "WBGene00020142", "A0A1T5HUK9", "WBGene00013732", "H2L0K0", "WBGene00020135", "O02168", "WBGene00020633", "Q9N501", "WBGene00021527", "P34379", "WBGene00017045", "Q23023", "WBGene00006786", "Q22342", "WBGene00020334", "Q95XH2", "WBGene00022078", "species_76577", "Q9XUY2", "WBGene00010115", "P45894", "WBGene00019801", "Q95ZQ4", "WBGene00020142", "A0A1T5HUK9", "WBGene00013732", "H2L0K0", "WBGene00020135", "O02168", "WBGene00020633", "Q9N501", "WBGene00021527", "Q22342", "WBGene00020334", "Q23023", "WBGene00006786", "Q95XH2", "WBGene00022078", "P34379", "WBGene00017045" ] }, "reaction_10555452": { "compartment": "compartment_70101", "id": "reaction_10555452", "reactome": "R-CEL-5681987", "name": "LC3 is cleaved by ATG4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10555433" ], "products": [ "species_10555340" ], "modifiers": [ [ "species_10555449", "catalyst" ] ], "additional_components": [ "Q23536", "WBGene00002981", "Q09490", "WBGene00002980", "Q23536", "WBGene00002981", "Q09490", "WBGene00002980", "K8ESC5", "WBGene00013595" ] }, "reaction_10555454": { "compartment": "compartment_70101", "id": "reaction_10555454", "reactome": "R-CEL-5682011", "name": "LC3 binds ATG7 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10555407", "species_10555340" ], "products": [ "species_10555418" ], "modifiers": [], "additional_components": [ "G5EBK4", "WBGene00010882", "Q23536", "WBGene00002981", "Q09490", "WBGene00002980", "G5EBK4", "WBGene00010882", "Q23536", "WBGene00002981", "Q09490", "WBGene00002980" ] }, "reaction_10555456": { "compartment": "compartment_70101", "id": "reaction_10555456", "reactome": "R-CEL-5682377", "name": "LC3 de-lipidation by ATG4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10555350" ], "products": [ "species_10555340", "species_5681998" ], "modifiers": [ [ "species_10555449", "catalyst" ] ], "additional_components": [ "species_8959490", "Q23536", "WBGene00002981", "Q09490", "WBGene00002980", "Q23536", "WBGene00002981", "Q09490", "WBGene00002980", "K8ESC5", "WBGene00013595" ] }, "reaction_10536642": { "compartment": "compartment_70101", "id": "reaction_10536642", "reactome": "R-CEL-1632857", "name": "ULK1 phosphorylates AMBRA1:BECN1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10536602", "species_113592" ], "products": [ "species_29370", "species_10536608" ], "modifiers": [ [ "species_10536639", "catalyst" ] ], "additional_components": [ "Q9XWQ4", "WBGene00013695", "Q9TXI7", "WBGene00006932", "Q22592", "WBGene00000247", "Q23669", "WBGene00014151", "Q65XS9", "WBGene00043067", "A0AAC1", "WBGene00012424", "Q7YTJ8", "WBGene00012425", "Q21557", "WBGene00010888", "Q22799", "WBGene00001005", "Q9XWQ4", "WBGene00013695", "Q9TXI7", "WBGene00006932", "Q22592", "WBGene00000247", "Q23669", "WBGene00014151", "Q65XS9", "WBGene00043067", "A0AAC1", "WBGene00012424", "Q7YTJ8", "WBGene00012425", "Q21557", "WBGene00010888", "Q22799", "WBGene00001005", "species_76577", "Q9XUY2", "WBGene00010115", "P45894", "WBGene00019801", "Q95ZQ4", "WBGene00020142", "A0A1T5HUK9", "WBGene00013732", "H2L0K0", "WBGene00020135", "O02168", "WBGene00020633", "Q9N501", "WBGene00021527", "Q22342", "WBGene00020334", "Q95XH2", "WBGene00022078", "P34379", "WBGene00017045", "Q23023", "WBGene00006786" ] }, "reaction_10554883": { "compartment": "compartment_12045", "id": "reaction_10554883", "reactome": "R-CEL-5672012", "name": "Beclin-1 complex phosphorylates PtdIns", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_426639" ], "products": [ "species_29370", "species_5676030" ], "modifiers": [ [ "species_10554880", "catalyst" ] ], "additional_components": [ "Q9TXI7", "WBGene00006932", "Q23669", "WBGene00014151", "Q9XWQ4", "WBGene00013695", "Q22592", "WBGene00000247" ] }, "reaction_10555396": { "compartment": "compartment_70101", "id": "reaction_10555396", "reactome": "R-CEL-5679205", "name": "ULK1 phosphorylates Beclin-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10555394" ], "products": [ "species_29370", "species_10554880" ], "modifiers": [ [ "species_10536639", "catalyst" ] ], "additional_components": [ "Q9TXI7", "WBGene00006932", "Q22592", "WBGene00000247", "Q23669", "WBGene00014151", "Q9XWQ4", "WBGene00013695", "Q9TXI7", "WBGene00006932", "Q23669", "WBGene00014151", "Q9XWQ4", "WBGene00013695", "Q22592", "WBGene00000247", "species_76577", "Q9XUY2", "WBGene00010115", "P45894", "WBGene00019801", "Q95ZQ4", "WBGene00020142", "A0A1T5HUK9", "WBGene00013732", "H2L0K0", "WBGene00020135", "O02168", "WBGene00020633", "Q9N501", "WBGene00021527", "Q22342", "WBGene00020334", "Q95XH2", "WBGene00022078", "P34379", "WBGene00017045", "Q23023", "WBGene00006786" ] }, "reaction_10554887": { "compartment": "compartment_17938", "id": "reaction_10554887", "reactome": "R-CEL-5672017", "name": "Rheb in the MTORC1 complex hydrolyses GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10510588" ], "products": [ "species_10519963" ], "modifiers": [ [ "species_10510588", "catalyst" ] ], "additional_components": [ "Q19425", "WBGene00008774", "species_29420", "G5EGB3", "WBGene00012497", "Q22743", "WBGene00006414", "species_29438", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "P91040", "WBGene00015697", "Q95Q95", "WBGene00002583", "Q68TI8", "WBGene00000911", "P34443", "WBGene00010038", "P34443", "WBGene00010038", "species_29420", "Q19425", "WBGene00008774", "G5EGB3", "WBGene00012497", "Q22743", "WBGene00006414", "species_29438", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "P91040", "WBGene00015697", "Q95Q95", "WBGene00002583", "Q68TI8", "WBGene00000911", "Q19425", "WBGene00008774", "species_29420", "G5EGB3", "WBGene00012497", "Q22743", "WBGene00006414", "species_29438", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "P91040", "WBGene00015697", "Q95Q95", "WBGene00002583", "Q68TI8", "WBGene00000911", "P34443", "WBGene00010038" ] }, "reaction_10555399": { "compartment": "compartment_70101", "id": "reaction_10555399", "reactome": "R-CEL-5679206", "name": "MTMR14, MTMR3 dephosphorylate PI3P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5676030" ], "products": [ "species_426639" ], "modifiers": [ [ "species_10537226", "catalyst" ] ], "additional_components": [ "WBGene00003476" ] }, "reaction_10555401": { "compartment": "compartment_70101", "id": "reaction_10555401", "reactome": "R-CEL-5679239", "name": "ULK complex translocates to the ER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10555256" ], "products": [ "species_10536639" ], "modifiers": [], "additional_components": [ "species_76577", "Q9XUY2", "WBGene00010115", "P45894", "WBGene00019801", "Q95ZQ4", "WBGene00020142", "A0A1T5HUK9", "WBGene00013732", "H2L0K0", "WBGene00020135", "O02168", "WBGene00020633", "Q9N501", "WBGene00021527", "P34379", "WBGene00017045", "Q23023", "WBGene00006786", "Q22342", "WBGene00020334", "Q95XH2", "WBGene00022078", "species_76577", "Q9XUY2", "WBGene00010115", "P45894", "WBGene00019801", "Q95ZQ4", "WBGene00020142", "A0A1T5HUK9", "WBGene00013732", "H2L0K0", "WBGene00020135", "O02168", "WBGene00020633", "Q9N501", "WBGene00021527", "Q22342", "WBGene00020334", "Q95XH2", "WBGene00022078", "P34379", "WBGene00017045", "Q23023", "WBGene00006786" ] }, "reaction_10554891": { "compartment": "compartment_70101", "id": "reaction_10554891", "reactome": "R-CEL-5672817", "name": "Active MTORC1 binds the ULK1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10510588", "species_10554659" ], "products": [ "species_10554861" ], "modifiers": [], "additional_components": [ "Q19425", "WBGene00008774", "species_29420", "G5EGB3", "WBGene00012497", "Q22743", "WBGene00006414", "species_29438", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "P91040", "WBGene00015697", "Q95Q95", "WBGene00002583", "Q68TI8", "WBGene00000911", "P34443", "WBGene00010038", "Q22342", "WBGene00020334", "Q23023", "WBGene00006786", "Q95XH2", "WBGene00022078", "P34379", "WBGene00017045", "Q22342", "WBGene00020334", "Q23023", "WBGene00006786", "Q95XH2", "WBGene00022078", "P34379", "WBGene00017045", "Q19425", "WBGene00008774", "species_29420", "G5EGB3", "WBGene00012497", "Q22743", "WBGene00006414", "species_29438", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "P91040", "WBGene00015697", "Q95Q95", "WBGene00002583", "Q68TI8", "WBGene00000911", "P34443", "WBGene00010038" ] }, "reaction_10555403": { "compartment": "compartment_70101", "id": "reaction_10555403", "reactome": "R-CEL-5679255", "name": "WIPI2 binds ATG12:ATG5:ATG16L", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10555375", "species_10555373" ], "products": [ "species_10555377" ], "modifiers": [], "additional_components": [ "O16466", "WBGene00018294", "species_5334668", "Q19124", "WBGene00017178", "Q09406", "WBGene00019427", "Q10931", "WBGene00002982", "Q3V5I7", "WBGene00022152", "Q19124", "WBGene00017178", "Q09406", "WBGene00019427", "Q10931", "WBGene00002982", "Q3V5I7", "WBGene00022152", "O16466", "WBGene00018294", "species_5334668" ] }, "reaction_10555405": { "compartment": "compartment_70101", "id": "reaction_10555405", "reactome": "R-CEL-5679266", "name": "Beclin-1 complex translocates to the ER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10536600" ], "products": [ "species_10555394" ], "modifiers": [], "additional_components": [ "Q9XWQ4", "WBGene00013695", "Q9TXI7", "WBGene00006932", "Q22592", "WBGene00000247", "Q23669", "WBGene00014151", "Q9TXI7", "WBGene00006932", "Q22592", "WBGene00000247", "Q23669", "WBGene00014151", "Q9XWQ4", "WBGene00013695" ] }, "reaction_10555469": { "compartment": "compartment_12045", "id": "reaction_10555469", "reactome": "R-CEL-5682385", "name": "The phagophore extends from the PIP3-enriched structure", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10554880" ], "products": [ "species_10555460" ], "modifiers": [ [ "species_10555465", "catalyst" ] ], "additional_components": [ "Q9TXI7", "WBGene00006932", "Q23669", "WBGene00014151", "Q9XWQ4", "WBGene00013695", "Q22592", "WBGene00000247", "Q9XWQ4", "WBGene00013695", "Q9TXI7", "WBGene00006932", "Q23669", "WBGene00014151", "Q22592", "WBGene00000247", "WBGene00020706" ] }, "reaction_10555598": { "compartment": "compartment_70101", "id": "reaction_10555598", "reactome": "R-CEL-5683925", "name": "ULK1 is dephosphorylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10554866" ], "products": [ "species_29372", "species_10554659" ], "modifiers": [], "additional_components": [ "Q22342", "WBGene00020334", "Q23023", "WBGene00006786", "Q95XH2", "WBGene00022078", "P34379", "WBGene00017045", "Q22342", "WBGene00020334", "Q23023", "WBGene00006786", "Q95XH2", "WBGene00022078", "P34379", "WBGene00017045" ] }, "reaction_10555537": { "compartment": "compartment_70101", "id": "reaction_10555537", "reactome": "R-CEL-5682896", "name": "LC3:ATG7 dimer binds ATG3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10555418", "species_10555352" ], "products": [ "species_10555420" ], "modifiers": [], "additional_components": [ "G5EBK4", "WBGene00010882", "Q23536", "WBGene00002981", "Q09490", "WBGene00002980", "WBGene00021922", "Q9N369", "WBGene00021922", "G5EBK4", "WBGene00010882", "Q23536", "WBGene00002981", "Q09490", "WBGene00002980" ] }, "reaction_10555411": { "compartment": "compartment_70101", "id": "reaction_10555411", "reactome": "R-CEL-5681980", "name": "ATG12 binds ATG7 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10555407", "species_10555366" ], "products": [ "species_10555409" ], "modifiers": [], "additional_components": [ "G5EBK4", "WBGene00010882", "WBGene00002982", "Q10931", "WBGene00002982", "G5EBK4", "WBGene00010882" ] }, "reaction_10555093": { "compartment": "compartment_70101", "id": "reaction_10555093", "reactome": "R-CEL-5673768", "name": "p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10554868" ], "products": [ "species_29370", "species_10555091" ], "modifiers": [ [ "species_10519954", "catalyst" ] ], "additional_components": [ "Q22342", "WBGene00020334", "Q23023", "WBGene00006786", "Q95XH2", "WBGene00022078", "P34379", "WBGene00017045", "Q19425", "WBGene00008774", "species_29420", "G5EGB3", "WBGene00012497", "Q22743", "WBGene00006414", "species_29438", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "P91040", "WBGene00015697", "Q95Q95", "WBGene00002583", "Q68TI8", "WBGene00000911", "P34443", "WBGene00010038", "Q22342", "WBGene00020334", "Q23023", "WBGene00006786", "Q95XH2", "WBGene00022078", "P34379", "WBGene00017045", "P34443", "WBGene00010038", "species_29438", "Q19425", "WBGene00008774", "species_29420", "G5EGB3", "WBGene00012497", "Q22743", "WBGene00006414", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "P91040", "WBGene00015697", "Q95Q95", "WBGene00002583", "Q68TI8", "WBGene00000911", "species_76577", "Q9XUY2", "WBGene00010115", "P45894", "WBGene00019801", "Q95ZQ4", "WBGene00020142", "A0A1T5HUK9", "WBGene00013732", "H2L0K0", "WBGene00020135", "O02168", "WBGene00020633", "Q9N501", "WBGene00021527" ] }, "reaction_10555284": { "compartment": "compartment_70101", "id": "reaction_10555284", "reactome": "R-CEL-5676229", "name": "WIPIs bind PI3P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5693050", "species_10555280" ], "products": [ "species_10555282" ], "modifiers": [], "additional_components": [ "O16466", "WBGene00018294", "O16466", "WBGene00018294", "species_1806200" ] }, "reaction_10563248": { "compartment": "compartment_6791047", "id": "reaction_10563248", "reactome": "R-CEL-6807872", "name": "Active ARF recruits coatomer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10563199", "species_10563244" ], "products": [ "species_10563246" ], "modifiers": [], "additional_components": [ "G5EGG0", "WBGene00010713", "Q9UAQ6", "WBGene00004266", "species_29438", "G5EGS5", "WBGene00007703", "Q94231", "WBGene00000190", "Q09236", "WBGene00015734", "Q22498", "WBGene00011775", "Q9TYL9", "WBGene00021292", "O17901", "WBGene00010333", "Q20168", "WBGene00009542", "O62246", "WBGene00009732", "Q9N4H7", "WBGene00022119", "Q09236", "WBGene00015734", "Q22498", "WBGene00011775", "Q9TYL9", "WBGene00021292", "O17901", "WBGene00010333", "Q20168", "WBGene00009542", "O62246", "WBGene00009732", "Q9N4H7", "WBGene00022119", "G5EGG0", "WBGene00010713", "Q9UAQ6", "WBGene00004266", "species_29438", "G5EGS5", "WBGene00007703", "Q94231", "WBGene00000190" ] }, "reaction_10563616": { "compartment": "compartment_20699", "id": "reaction_10563616", "reactome": "R-CEL-6809011", "name": "cis-Golgi t-SNAREs bind YKT6 on tethered vesicle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10563612", "species_10563597" ], "products": [ "species_10563614" ], "modifiers": [], "additional_components": [ "Q95ZW1", "WBGene00017273", "P41941", "WBGene00007128", "Q20797", "WBGene00006373", "G5EEU1", "WBGene00043064", "Q9N3Y1", "WBGene00021536", "Q19989", "WBGene00018017", "Q9TXZ9", "WBGene00015164", "Q18849", "WBGene00009500", "Q22328", "WBGene00002976", "A0A1N7SYP5", "WBGene00009500", "P48583", "WBGene00001331", "Q09473", "WBGene00016195", "G5EEU1", "WBGene00043064", "G5EGG0", "WBGene00010713", "Q9UAQ6", "WBGene00004266", "species_29438", "Q9N4H7", "WBGene00022119", "Q20168", "WBGene00009542", "O62246", "WBGene00009732", "Q22498", "WBGene00011775", "O17901", "WBGene00010333", "Q09236", "WBGene00015734", "Q9TYL9", "WBGene00021292", "O44738", "WBGene00019003", "Q20546", "WBGene00009829", "A4F319", "WBGene00011606", "Q9U1Z4", "WBGene00013360", "O17528", "WBGene00004766", "E0AHA7", "WBGene00006803", "G5EFW3", "WBGene00004855", "Q21408", "WBGene00004951", "Q21270", "WBGene00019481", "Q6AW08", "WBGene00022121", "Q95XZ0", "WBGene00021784", "G5EE66", "WBGene00003258", "O44502", "WBGene00019820", "Q21444", "WBGene00000585", "P91151", "WBGene00016608", "Q9U3K1", "WBGene00008687", "Q9N3Y1", "WBGene00021536", "Q19989", "WBGene00018017", "Q9TXZ9", "WBGene00015164", "Q18849", "WBGene00009500", "Q22328", "WBGene00002976", "A0A1N7SYP5", "WBGene00009500", "P48583", "WBGene00001331", "Q09473", "WBGene00016195", "G5EEU1", "WBGene00043064", "G5EGG0", "WBGene00010713", "Q9UAQ6", "WBGene00004266", "species_29438", "Q9N4H7", "WBGene00022119", "Q20168", "WBGene00009542", "O62246", "WBGene00009732", "Q22498", "WBGene00011775", "O17901", "WBGene00010333", "Q09236", "WBGene00015734", "Q9TYL9", "WBGene00021292", "O44738", "WBGene00019003", "Q20546", "WBGene00009829", "A4F319", "WBGene00011606", "Q9U1Z4", "WBGene00013360", "O17528", "WBGene00004766", "E0AHA7", "WBGene00006803", "G5EFW3", "WBGene00004855", "Q21408", "WBGene00004951", "Q21270", "WBGene00019481", "Q6AW08", "WBGene00022121", "Q95XZ0", "WBGene00021784", "G5EE66", "WBGene00003258", "O44502", "WBGene00019820", "Q21444", "WBGene00000585", "P91151", "WBGene00016608", "Q9U3K1", "WBGene00008687", "Q95ZW1", "WBGene00017273", "P41941", "WBGene00007128", "Q20797", "WBGene00006373" ] }, "reaction_10563202": { "compartment": "compartment_6791047", "id": "reaction_10563202", "reactome": "R-CEL-6807868", "name": "GBF1 stimulates ARF nucleotide exchange", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10563193" ], "products": [ "species_10563199", "species_29370" ], "modifiers": [ [ "species_10563193", "catalyst" ] ], "additional_components": [ "Q94231", "WBGene00000190", "species_29420", "G5EGG0", "WBGene00010713", "Q9UAQ6", "WBGene00004266", "species_29438", "G5EGS5", "WBGene00007703", "G5EGG0", "WBGene00010713", "Q9UAQ6", "WBGene00004266", "species_29438", "G5EGS5", "WBGene00007703", "Q94231", "WBGene00000190", "Q94231", "WBGene00000190", "species_29420", "G5EGG0", "WBGene00010713", "Q9UAQ6", "WBGene00004266", "species_29438", "G5EGS5", "WBGene00007703" ] }, "reaction_10563622": { "compartment": "compartment_20699", "id": "reaction_10563622", "reactome": "R-CEL-6809014", "name": "cis-Golgi cis-SNARE binds NSF and SNAPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10563618", "species_10557345", "species_10557329" ], "products": [ "species_10563620" ], "modifiers": [], "additional_components": [ "Q9TXZ9", "WBGene00015164", "Q95ZW1", "WBGene00017273", "P41941", "WBGene00007128", "Q20797", "WBGene00006373", "G5EEU1", "WBGene00043064", "Q18921", "WBGene00017016", "Q94392", "WBGene00003818", "Q18921", "WBGene00017016", "Q94392", "WBGene00003818", "Q9TXZ9", "WBGene00015164", "Q95ZW1", "WBGene00017273", "P41941", "WBGene00007128", "Q20797", "WBGene00006373", "G5EEU1", "WBGene00043064" ] }, "reaction_10563195": { "compartment": "compartment_6791047", "id": "reaction_10563195", "reactome": "R-CEL-6807866", "name": "GBF1 recruits ARF:GDP to the ERGIC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10563181", "species_10563191" ], "products": [ "species_10563193" ], "modifiers": [], "additional_components": [ "G5EGG0", "WBGene00010713", "Q9UAQ6", "WBGene00004266", "species_29438", "G5EGS5", "WBGene00007703", "Q94231", "WBGene00000190", "species_29420", "Q94231", "WBGene00000190", "species_29420", "G5EGG0", "WBGene00010713", "Q9UAQ6", "WBGene00004266", "species_29438", "G5EGS5", "WBGene00007703" ] }, "reaction_10563419": { "compartment": "compartment_6791047", "id": "reaction_10563419", "reactome": "R-CEL-6807877", "name": "ARFGAPs stimulate ARF GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10563328" ], "products": [ "species_10563262", "species_10563179", "species_10563416", "species_10563191" ], "modifiers": [ [ "species_10563328", "catalyst" ] ], "additional_components": [ "Q9TXZ9", "WBGene00015164", "Q20546", "WBGene00009829", "O17528", "WBGene00004766", "A4F319", "WBGene00011606", "Q9U1Z4", "WBGene00013360", "O44738", "WBGene00019003", "Q22328", "WBGene00002976", "A0A1N7SYP5", "WBGene00009500", "Q18849", "WBGene00009500", "P48583", "WBGene00001331", "Q09473", "WBGene00016195", "G5EEU1", "WBGene00043064", "E0AHA7", "WBGene00006803", "G5EFW3", "WBGene00004855", "Q21408", "WBGene00004951", "Q09236", "WBGene00015734", "Q22498", "WBGene00011775", "Q9TYL9", "WBGene00021292", "O17901", "WBGene00010333", "Q20168", "WBGene00009542", "O62246", "WBGene00009732", "Q9N4H7", "WBGene00022119", "G5EGG0", "WBGene00010713", "Q9UAQ6", "WBGene00004266", "species_29438", "G5EGS5", "WBGene00007703", "Q94231", "WBGene00000190", "Q09531", "WBGene00017217", "P90904", "WBGene00010500", "Q09531", "WBGene00017217", "P90904", "WBGene00010500", "WBGene00007703", "Q9UAQ6", "WBGene00004266", "species_29438", "G5EGG0", "WBGene00010713", "Q09236", "WBGene00015734", "Q9TYL9", "WBGene00021292", "Q22498", "WBGene00011775", "O17901", "WBGene00010333", "Q9N4H7", "WBGene00022119", "Q20168", "WBGene00009542", "O62246", "WBGene00009732", "Q20546", "WBGene00009829", "Q9U1Z4", "WBGene00013360", "A4F319", "WBGene00011606", "O17528", "WBGene00004766", "O44738", "WBGene00019003", "P48583", "WBGene00001331", "Q09473", "WBGene00016195", "A0A1N7SYP5", "WBGene00009500", "Q18849", "WBGene00009500", "Q22328", "WBGene00002976", "G5EEU1", "WBGene00043064", "Q9TXZ9", "WBGene00015164", "E0AHA7", "WBGene00006803", "G5EFW3", "WBGene00004855", "Q21408", "WBGene00004951", "Q94231", "WBGene00000190", "species_29420", "Q9TXZ9", "WBGene00015164", "Q20546", "WBGene00009829", "O17528", "WBGene00004766", "A4F319", "WBGene00011606", "Q9U1Z4", "WBGene00013360", "O44738", "WBGene00019003", "Q22328", "WBGene00002976", "A0A1N7SYP5", "WBGene00009500", "Q18849", "WBGene00009500", "P48583", "WBGene00001331", "Q09473", "WBGene00016195", "G5EEU1", "WBGene00043064", "E0AHA7", "WBGene00006803", "G5EFW3", "WBGene00004855", "Q21408", "WBGene00004951", "Q09236", "WBGene00015734", "Q22498", "WBGene00011775", "Q9TYL9", "WBGene00021292", "O17901", "WBGene00010333", "Q20168", "WBGene00009542", "O62246", "WBGene00009732", "Q9N4H7", "WBGene00022119", "G5EGG0", "WBGene00010713", "Q9UAQ6", "WBGene00004266", "species_29438", "G5EGS5", "WBGene00007703", "Q94231", "WBGene00000190", "Q09531", "WBGene00017217", "P90904", "WBGene00010500" ] }, "reaction_10563453": { "compartment": "compartment_432051", "id": "reaction_10563453", "reactome": "R-CEL-6809003", "name": "ERGIC-to-Golgi vesicles bind dynein:dynactin ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10563416", "species_10553033" ], "products": [ "species_10563451" ], "modifiers": [], "additional_components": [ "Q9UAQ6", "WBGene00004266", "species_29438", "G5EGG0", "WBGene00010713", "Q09236", "WBGene00015734", "Q9TYL9", "WBGene00021292", "Q22498", "WBGene00011775", "O17901", "WBGene00010333", "Q9N4H7", "WBGene00022119", "Q20168", "WBGene00009542", "O62246", "WBGene00009732", "Q20546", "WBGene00009829", "Q9U1Z4", "WBGene00013360", "A4F319", "WBGene00011606", "O17528", "WBGene00004766", "O44738", "WBGene00019003", "P48583", "WBGene00001331", "Q09473", "WBGene00016195", "A0A1N7SYP5", "WBGene00009500", "Q18849", "WBGene00009500", "Q22328", "WBGene00002976", "G5EEU1", "WBGene00043064", "Q9TXZ9", "WBGene00015164", "E0AHA7", "WBGene00006803", "G5EFW3", "WBGene00004855", "Q21408", "WBGene00004951", "Q19020", "WBGene00000962", "O45087", "WBGene00015927", "Q65XS9", "WBGene00043067", "A0AAC1", "WBGene00012424", "Q7YTJ8", "WBGene00012425", "Q21557", "WBGene00010888", "Q22799", "WBGene00001005", "G5ED34", "WBGene00001007", "species_29420", "species_29438", "Q9NA98", "WBGene00013168", "P34685", "WBGene00000292", "P34686", "WBGene00000293", "Q18194", "WBGene00016124", "Q9N4I1", "WBGene00022118", "Q9N3F1", "WBGene00021827", "Q9GYR2", "WBGene00016793", "Q09248", "WBGene00001018", "E2JKZ0", "WBGene00001017", "Q19020", "WBGene00000962", "O45087", "WBGene00015927", "Q65XS9", "WBGene00043067", "A0AAC1", "WBGene00012424", "Q7YTJ8", "WBGene00012425", "Q21557", "WBGene00010888", "Q22799", "WBGene00001005", "G5ED34", "WBGene00001007", "species_29420", "species_29438", "Q9NA98", "WBGene00013168", "P34685", "WBGene00000292", "P34686", "WBGene00000293", "Q18194", "WBGene00016124", "Q9N4I1", "WBGene00022118", "Q9N3F1", "WBGene00021827", "Q9GYR2", "WBGene00016793", "Q09248", "WBGene00001018", "E2JKZ0", "WBGene00001017", "Q9UAQ6", "WBGene00004266", "G5EGG0", "WBGene00010713", "Q09236", "WBGene00015734", "Q9TYL9", "WBGene00021292", "Q22498", "WBGene00011775", "O17901", "WBGene00010333", "Q9N4H7", "WBGene00022119", "Q20168", "WBGene00009542", "O62246", "WBGene00009732", "Q20546", "WBGene00009829", "Q9U1Z4", "WBGene00013360", "A4F319", "WBGene00011606", "O17528", "WBGene00004766", "O44738", "WBGene00019003", "P48583", "WBGene00001331", "Q09473", "WBGene00016195", "A0A1N7SYP5", "WBGene00009500", "Q18849", "WBGene00009500", "Q22328", "WBGene00002976", "G5EEU1", "WBGene00043064", "Q9TXZ9", "WBGene00015164", "E0AHA7", "WBGene00006803", "G5EFW3", "WBGene00004855", "Q21408", "WBGene00004951" ] }, "reaction_10563183": { "compartment": "compartment_6791047", "id": "reaction_10563183", "reactome": "R-CEL-6807864", "name": "RAB1:GTP recruits GBF1 to the ERGIC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10563179", "species_10563177", "species_10557302" ], "products": [ "species_10563181" ], "modifiers": [], "additional_components": [ "WBGene00007703", "Q9UAQ6", "WBGene00004266", "species_29438", "G5EGG0", "WBGene00010713", "G5EGG0", "WBGene00010713", "Q9UAQ6", "WBGene00004266", "species_29438", "G5EGS5", "WBGene00007703" ] }, "reaction_10524156": { "compartment": "compartment_17906", "id": "reaction_10524156", "reactome": "R-CEL-434382", "name": "ACSL3,4 ligates coenzyme A (CoA-SH) to palmitate yielding palmitoyl-coenzyme A in the pancreatic beta cell", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_3632881", "species_76194" ], "products": [ "species_1132084", "species_200993", "species_76577" ], "modifiers": [ [ "species_10524153", "catalyst" ] ], "additional_components": [ "A0A4V0ING4", "WBGene00016716", "Q20121", "WBGene00018152" ] }, "reaction_10559061": { "compartment": "compartment_7660", "id": "reaction_10559061", "reactome": "R-CEL-6791227", "name": "47S pre-rRNA is nucleolytically processed at A' (01,A1), site A0, and site 02 (site 6) to yield 45S pre-rRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10559047" ], "products": [ "species_10559051" ], "modifiers": [ [ "species_10559056", "catalyst" ], [ "species_10558582", "catalyst" ], [ "species_10559059", "catalyst" ], [ "species_10558737", "catalyst" ], [ "species_10558715", "catalyst" ], [ "species_10558761", "catalyst" ] ], "additional_components": [ "Q9XX15", "WBGene00012652", "Q22053", "WBGene00001423", "Q21568", "WBGene00010896", "O45012", "WBGene00020915", "Q21276", "WBGene00010627", "A9D0C6", "WBGene00020171", "O16311", "WBGene00015461", "Q95XY4", "WBGene00021789", "Q8MNX1", "WBGene00020705", "Q23314", "WBGene00013892", "Q21736", "WBGene00011032", "P34580", "WBGene00012059", "Q9N3Q9", "WBGene00021660", "Q22046", "WBGene00011311", "Q18038", "WBGene00002850", "Q23494", "WBGene00022742", "Q19873", "WBGene00009211", "A7DT40", "WBGene00045433", "Q9N477", "WBGene00021276", "Q9XUU8", "WBGene00010582", "Q23495", "WBGene00022739", "P51403", "WBGene00004471", "Q09462", "WBGene00007623", "Q9NEN6", "WBGene00004475", "Q9N306", "WBGene00022021", "Q23400", "WBGene00022852", "Q23312", "WBGene00004476", "Q20228", "WBGene00004478", "P48150", "WBGene00004483", "P41843", "WBGene00020601", "Q19545", "WBGene00007050", "Q93638", "WBGene00009266", "P91280", "WBGene00017855", "Q9U2I4", "WBGene00012756", "O01513", "WBGene00016740", "O62518", "WBGene00014083", "Q9XW58", "WBGene00013544", "Q2WF63", "WBGene00019219", "P42000", "WBGene00015104", "P91341", "WBGene00018891", "Q19433", "WBGene00017435", "O62477", "WBGene00012887", "O18215", "WBGene00013143", "P34305", "WBGene00015525", "Q9XX15", "WBGene00012652", "Q22053", "WBGene00001423", "Q21568", "WBGene00010896", "O45012", "WBGene00020915", "Q21276", "WBGene00010627", "A9D0C6", "WBGene00020171", "O16311", "WBGene00015461", "Q95XY4", "WBGene00021789", "Q8MNX1", "WBGene00020705", "Q23314", "WBGene00013892", "Q21736", "WBGene00011032", "P34580", "WBGene00012059", "Q9N3Q9", "WBGene00021660", "Q22046", "WBGene00011311", "Q18038", "WBGene00002850", "Q23494", "WBGene00022742", "Q19873", "WBGene00009211", "A7DT40", "WBGene00045433", "Q9N477", "WBGene00021276", "Q9XUU8", "WBGene00010582", "Q23495", "WBGene00022739", "P51403", "WBGene00004471", "Q09462", "WBGene00007623", "Q9NEN6", "WBGene00004475", "Q9N306", "WBGene00022021", "Q23400", "WBGene00022852", "Q23312", "WBGene00004476", "Q20228", "WBGene00004478", "P48150", "WBGene00004483", "P41843", "WBGene00020601", "Q19545", "WBGene00007050", "Q93638", "WBGene00009266", "P91280", "WBGene00017855", "Q9U2I4", "WBGene00012756", "O01513", "WBGene00016740", "O62518", "WBGene00014083", "Q9XW58", "WBGene00013544", "Q2WF63", "WBGene00019219", "P42000", "WBGene00015104", "P91341", "WBGene00018891", "Q19433", "WBGene00017435", "O62477", "WBGene00012887", "O18215", "WBGene00013143", "P34305", "WBGene00015525", "WBGene00006964", "WBGene00012342", "WBGene00004705", "WBGene00015104", "A7DT40", "WBGene00045433", "Q9N477", "WBGene00021276", "Q9XUU8", "WBGene00010582", "Q23495", "WBGene00022739", "Q95XY4", "WBGene00021789", "Q8MNX1", "WBGene00020705", "Q23314", "WBGene00013892" ] }, "reaction_10558907": { "compartment": "compartment_7660", "id": "reaction_10558907", "reactome": "R-CEL-6791222", "name": "21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10558872" ], "products": [ "species_10558880" ], "modifiers": [ [ "species_10558904", "catalyst" ], [ "species_10558594", "catalyst" ], [ "species_10558892", "catalyst" ], [ "species_10558582", "catalyst" ] ], "additional_components": [ "Q9XX15", "WBGene00012652", "Q22053", "WBGene00001423", "Q21568", "WBGene00010896", "O45012", "WBGene00020915", "Q21276", "WBGene00010627", "A9D0C6", "WBGene00020171", "O16311", "WBGene00015461", "Q95XY4", "WBGene00021789", "Q8MNX1", "WBGene00020705", "Q23314", "WBGene00013892", "Q21736", "WBGene00011032", "P34580", "WBGene00012059", "Q9N3Q9", "WBGene00021660", "Q22046", "WBGene00011311", "Q18038", "WBGene00002850", "Q23494", "WBGene00022742", "Q19873", "WBGene00009211", "A7DT40", "WBGene00045433", "Q9N477", "WBGene00021276", "Q9XUU8", "WBGene00010582", "Q23495", "WBGene00022739", "P51403", "WBGene00004471", "Q09462", "WBGene00007623", "Q9NEN6", "WBGene00004475", "Q9N306", "WBGene00022021", "Q23400", "WBGene00022852", "Q23312", "WBGene00004476", "Q20228", "WBGene00004478", "P48150", "WBGene00004483", "P41843", "WBGene00020601", "Q19545", "WBGene00007050", "Q93638", "WBGene00009266", "P91280", "WBGene00017855", "Q9U2I4", "WBGene00012756", "O01513", "WBGene00016740", "O62518", "WBGene00014083", "Q9XW58", "WBGene00013544", "Q2WF63", "WBGene00019219", "P42000", "WBGene00015104", "P91341", "WBGene00018891", "Q19433", "WBGene00017435", "O62477", "WBGene00012887", "O18215", "WBGene00013143", "P34305", "WBGene00015525", "Q9XX15", "WBGene00012652", "Q22053", "WBGene00001423", "Q21568", "WBGene00010896", "O45012", "WBGene00020915", "Q21276", "WBGene00010627", "A9D0C6", "WBGene00020171", "O16311", "WBGene00015461", "Q95XY4", "WBGene00021789", "Q8MNX1", "WBGene00020705", "Q23314", "WBGene00013892", "Q21736", "WBGene00011032", "P34580", "WBGene00012059", "Q9N3Q9", "WBGene00021660", "Q22046", "WBGene00011311", "Q18038", "WBGene00002850", "Q23494", "WBGene00022742", "Q19873", "WBGene00009211", "A7DT40", "WBGene00045433", "Q9N477", "WBGene00021276", "Q9XUU8", "WBGene00010582", "Q23495", "WBGene00022739", "P51403", "WBGene00004471", "Q09462", "WBGene00007623", "Q9NEN6", "WBGene00004475", "Q9N306", "WBGene00022021", "Q23400", "WBGene00022852", "Q23312", "WBGene00004476", "Q20228", "WBGene00004478", "P48150", "WBGene00004483", "P41843", "WBGene00020601", "Q19545", "WBGene00007050", "Q93638", "WBGene00009266", "P91280", "WBGene00017855", "Q9U2I4", "WBGene00012756", "O01513", "WBGene00016740", "O62518", "WBGene00014083", "Q9XW58", "WBGene00013544", "Q2WF63", "WBGene00019219", "P42000", "WBGene00015104", "P91341", "WBGene00018891", "Q19433", "WBGene00017435", "O62477", "WBGene00012887", "O18215", "WBGene00013143", "P34305", "WBGene00015525", "Q9N3J4", "WBGene00021785", "G5EBX6", "WBGene00000796", "O16207", "WBGene00017916", "G5EDS8", "WBGene00009289", "Q95QG7", "WBGene00018305", "Q9XXD2", "WBGene00012966", "Q20128", "WBGene00018154", "Q95XD0", "WBGene00022232", "Q93830", "WBGene00010325", "Q17533", "WBGene00007201", "G5EG59", "WBGene00000798", "Q9N4P9", "WBGene00000202", "Q23223", "WBGene00012342", "WBGene00000796", "WBGene00000798", "WBGene00012342" ] }, "reaction_10558639": { "compartment": "compartment_7660", "id": "reaction_10558639", "reactome": "R-CEL-6791219", "name": "32S pre-rRNA is nucleolytically processed at site 4 (4a) to yield 12S pre-rRNA and 28S rRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10558620" ], "products": [ "species_10558572" ], "modifiers": [ [ "species_10558557", "catalyst" ], [ "species_10558562", "catalyst" ], [ "species_10558637", "catalyst" ], [ "species_10558618", "catalyst" ] ], "additional_components": [ "Q9U3B6", "WBGene00010709", "Q22006", "WBGene00004185", "Q9XWK5", "WBGene00012977", "O44984", "WBGene00006740", "Q09353", "WBGene00006736", "Q23238", "WBGene00006737", "Q95Y89", "WBGene00003063", "P91343", "WBGene00018893", "Q9U2A9", "WBGene00012978", "Q9U1T1", "WBGene00012393", "Q9U3B6", "WBGene00010709", "Q22006", "WBGene00004185", "Q9XWK5", "WBGene00012977", "O44984", "WBGene00006740", "Q09353", "WBGene00006736", "Q23238", "WBGene00006737", "Q9U1T1", "WBGene00012393", "WBGene00012393", "WBGene00010709", "Q17978", "WBGene00003507", "Q95Y89", "WBGene00003063", "Q09958", "WBGene00015941", "Q21086", "WBGene00003821", "Q95Y89", "WBGene00003063", "P91343", "WBGene00018893", "Q9U2A9", "WBGene00012978" ] }, "reaction_10570551": { "compartment": "compartment_70101", "id": "reaction_10570551", "reactome": "R-CEL-8983379", "name": "p-Y-STAT3:p-STAT5 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10570523" ], "products": [ "species_10570549" ], "modifiers": [], "additional_components": [ "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251" ] }, "reaction_10570525": { "compartment": "compartment_70101", "id": "reaction_10570525", "reactome": "R-CEL-8983373", "name": "p-Y-STAT3 binds p-STAT5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10570521", "species_10570515" ], "products": [ "species_10570523" ], "modifiers": [], "additional_components": [ "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111" ] }, "reaction_10533095": { "compartment": "compartment_7660", "id": "reaction_10533095", "reactome": "R-CEL-1363328", "name": "Phosphorylated p130 (RBL2) binds SCF(Skp2):Cks1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10532102", "species_10512514" ], "products": [ "species_10533093" ], "modifiers": [], "additional_components": [ "WBGene00003020", "G5ECU1", "WBGene00004807", "Q17389", "WBGene00000836", "Q17868", "WBGene00001051", "G5ECU1", "WBGene00004807", "Q17389", "WBGene00000836", "Q17868", "WBGene00001051", "G5EDT1", "WBGene00003020" ] }, "reaction_10533100": { "compartment": "compartment_7660", "id": "reaction_10533100", "reactome": "R-CEL-1363331", "name": "Ubiquitination of p130 (RBL2) by SCF (Skp2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502318", "species_10533093" ], "products": [ "species_10533097", "species_10512514" ], "modifiers": [ [ "species_10533093", "catalyst" ] ], "additional_components": [ "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "G5ECU1", "WBGene00004807", "Q17389", "WBGene00000836", "Q17868", "WBGene00001051", "G5EDT1", "WBGene00003020", "G5EDT1", "WBGene00003020", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "G5ECU1", "WBGene00004807", "Q17389", "WBGene00000836", "Q17868", "WBGene00001051", "G5ECU1", "WBGene00004807", "Q17389", "WBGene00000836", "Q17868", "WBGene00001051", "G5EDT1", "WBGene00003020" ] }, "reaction_10533069": { "compartment": "compartment_7660", "id": "reaction_10533069", "reactome": "R-CEL-1363274", "name": "Dephosphorylation of p107 (RBL1) by PP2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10532114" ], "products": [ "species_113550", "species_10532106" ], "modifiers": [ [ "species_10533066", "catalyst" ] ], "additional_components": [ "WBGene00003020", "WBGene00003020" ] }, "reaction_10533071": { "compartment": "compartment_7660", "id": "reaction_10533071", "reactome": "R-CEL-1363276", "name": "Dephosphorylation of p130 (RBL2) by PP2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10532102" ], "products": [ "species_113550", "species_10532081" ], "modifiers": [ [ "species_10533066", "catalyst" ] ], "additional_components": [ "WBGene00003020", "WBGene00003020" ] }, "reaction_10531928": { "compartment": "compartment_12045", "id": "reaction_10531928", "reactome": "R-CEL-1168376", "name": "STIM1 oligomerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10531921" ], "products": [ "species_10531923", "species_74016" ], "modifiers": [ [ "species_10531925", "catalyst" ] ], "additional_components": [ "species_74016", "G5EF60", "WBGene00021910", "G5EF60", "WBGene00021910", "Q9Y0A1", "WBGene00002173", "species_114520" ] }, "reaction_10542490": { "compartment": "compartment_12045", "id": "reaction_10542490", "reactome": "R-CEL-2089927", "name": "STIM1 binds TRPC1 forming STIM1:TRPC1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10542486", "species_10531923" ], "products": [ "species_10542488" ], "modifiers": [], "additional_components": [ "WBGene00006615", "G5EF60", "WBGene00021910", "G5EF60", "WBGene00021910", "Q8I6Y9", "WBGene00006615" ] }, "reaction_10542493": { "compartment": "compartment_70101", "id": "reaction_10542493", "reactome": "R-CEL-2089943", "name": "TRPC1 translocates calcium from the extracellular region to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74112" ], "products": [ "species_74016" ], "modifiers": [ [ "species_10542488", "catalyst" ] ], "additional_components": [ "G5EF60", "WBGene00021910", "Q8I6Y9", "WBGene00006615" ] }, "reaction_10514689": { "compartment": "compartment_70101", "id": "reaction_10514689", "reactome": "R-CEL-200681", "name": "FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29404", "species_200665", "species_113592" ], "products": [ "species_29372", "species_29370", "species_174404" ], "modifiers": [ [ "species_10513791", "catalyst" ] ], "additional_components": [ "WBGene00017777" ] }, "reaction_10513794": { "compartment": "compartment_70101", "id": "reaction_10513794", "reactome": "R-CEL-197958", "name": "FPGS-2 transforms THF to THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29404", "species_111355", "species_113592" ], "products": [ "species_29372", "species_29370", "species_197969" ], "modifiers": [ [ "species_10513791", "catalyst" ] ], "additional_components": [ "WBGene00017777" ] }, "reaction_10562914": { "compartment": "compartment_70101", "id": "reaction_10562914", "reactome": "R-CEL-6801342", "name": "MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6803257", "species_113592" ], "products": [ "species_29372", "species_70106", "species_29370", "species_200640" ], "modifiers": [ [ "species_10562911", "catalyst" ] ], "additional_components": [ "WBGene00013708" ] }, "reaction_10514628": { "compartment": "compartment_70101", "id": "reaction_10514628", "reactome": "R-CEL-200644", "name": "5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29366", "species_200739" ], "products": [ "species_70106", "species_29364", "species_200640" ], "modifiers": [ [ "species_10514625", "catalyst" ] ], "additional_components": [ "Q21285", "WBGene00000929" ] }, "reaction_10562916": { "compartment": "compartment_5460", "id": "reaction_10562916", "reactome": "R-CEL-6801456", "name": "MTHFD1L transforms 10-formyl-THF to HCOOH and THF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113548", "species_113581", "species_5389850" ], "products": [ "species_200671", "species_6801451", "species_113593" ], "modifiers": [ [ "species_10557703", "catalyst" ] ], "additional_components": [ "Q21285", "WBGene00000929" ] }, "reaction_10514694": { "compartment": "compartment_5460", "id": "reaction_10514694", "reactome": "R-CEL-200682", "name": "Mitochondrial FPGS-1 transforms THF to THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200671", "species_113593", "species_113552" ], "products": [ "species_113548", "species_113581", "species_200679" ], "modifiers": [ [ "species_10514691", "catalyst" ] ], "additional_components": [ "WBGene00017777" ] }, "reaction_10514697": { "compartment": "compartment_70101", "id": "reaction_10514697", "reactome": "R-CEL-200711", "name": "MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_29460", "species_197969" ], "products": [ "species_29372", "species_29370", "species_111353" ], "modifiers": [ [ "species_10514625", "catalyst" ] ], "additional_components": [ "Q21285", "WBGene00000929" ] }, "reaction_10514666": { "compartment": "compartment_876", "id": "reaction_10514666", "reactome": "R-CEL-200652", "name": "SLC19A1 transports 5-methyl-THF from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200709" ], "products": [ "species_200665" ], "modifiers": [ [ "species_10514663", "catalyst" ] ], "additional_components": [ "O45166", "WBGene00018138", "Q17766", "WBGene00007388", "Q22931", "WBGene00044738" ] }, "reaction_10513802": { "compartment": "compartment_70101", "id": "reaction_10513802", "reactome": "R-CEL-197963", "name": "DHFR2 reduces FOLA to DHF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_197965", "species_70106", "species_29364" ], "products": [ "species_29366", "species_73604" ], "modifiers": [ [ "species_10513799", "catalyst" ] ], "additional_components": [ "WBGene00007974" ] }, "reaction_10557706": { "compartment": "compartment_5460", "id": "reaction_10557706", "reactome": "R-CEL-5696839", "name": "MTHFD1L dimer ligates HCOOH to THF to form 10-formyl-THF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6801451", "species_200671", "species_113593" ], "products": [ "species_113548", "species_113581", "species_5389850" ], "modifiers": [ [ "species_10557703", "catalyst" ] ], "additional_components": [ "Q21285", "WBGene00000929" ] }, "reaction_10514699": { "compartment": "compartment_70101", "id": "reaction_10514699", "reactome": "R-CEL-200718", "name": "MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_200640" ], "products": [ "species_29366", "species_200739" ], "modifiers": [ [ "species_10514625", "catalyst" ] ], "additional_components": [ "Q21285", "WBGene00000929" ] }, "reaction_10513804": { "compartment": "compartment_70101", "id": "reaction_10513804", "reactome": "R-CEL-197972", "name": "DHF is reduced to tetrahydrofolate (THF)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_73604", "species_29364" ], "products": [ "species_111355", "species_29366" ], "modifiers": [ [ "species_10513799", "catalyst" ] ], "additional_components": [ "WBGene00007974" ] }, "reaction_10514701": { "compartment": "compartment_70616", "id": "reaction_10514701", "reactome": "R-CEL-200720", "name": "SLC25A32 transports THF from mitochondrial matrix to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200671" ], "products": [ "species_111355" ], "modifiers": [ [ "species_10514684", "catalyst" ] ], "additional_components": [ "WBGene00010459" ] }, "reaction_10514669": { "compartment": "compartment_70101", "id": "reaction_10514669", "reactome": "R-CEL-200661", "name": "MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111353" ], "products": [ "species_29356", "species_200640" ], "modifiers": [ [ "species_10514625", "catalyst" ] ], "additional_components": [ "Q21285", "WBGene00000929" ] }, "reaction_10514703": { "compartment": "compartment_876", "id": "reaction_10514703", "reactome": "R-CEL-200729", "name": "SLC46A1 transports FOLA from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200716" ], "products": [ "species_197965" ], "modifiers": [ [ "species_10514650", "catalyst" ] ], "additional_components": [ "Q9UAZ6", "WBGene00021159", "Q9XWL3", "WBGene00012811", "H2KZC0", "WBGene00016705", "Q20236", "WBGene00009582" ] }, "reaction_10563441": { "compartment": "compartment_5460", "id": "reaction_10563441", "reactome": "R-CEL-6808487", "name": "ALDH1L2 dehydrogenates 10-formyl-THFPG to THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113563", "species_6808499", "species_113521" ], "products": [ "species_113529", "species_200679", "species_113600", "species_29376" ], "modifiers": [ [ "species_10563438", "catalyst" ] ], "additional_components": [ "G5ECV9", "WBGene00000109" ] }, "reaction_10514705": { "compartment": "compartment_70101", "id": "reaction_10514705", "reactome": "R-CEL-200735", "name": "SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200736", "species_197969" ], "products": [ "species_29424", "species_200739" ], "modifiers": [ [ "species_10503873", "catalyst" ] ], "additional_components": [ "P50432", "WBGene00003214" ] }, "reaction_10514707": { "compartment": "compartment_70101", "id": "reaction_10514707", "reactome": "R-CEL-200740", "name": "5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_200640" ], "products": [ "species_111353" ], "modifiers": [ [ "species_10514625", "catalyst" ] ], "additional_components": [ "Q21285", "WBGene00000929" ] }, "reaction_10573332": { "compartment": "compartment_70101", "id": "reaction_10573332", "reactome": "R-CEL-9709098", "name": "DHFR dimer reduces FOLA to DHF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_197965", "species_70106", "species_29364" ], "products": [ "species_29366", "species_73604" ], "modifiers": [ [ "species_10573329", "catalyst" ] ], "additional_components": [ "Q93341", "WBGene00007974" ] }, "reaction_10514679": { "compartment": "compartment_70101", "id": "reaction_10514679", "reactome": "R-CEL-200676", "name": "MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_200739" ], "products": [ "species_29366", "species_174404" ], "modifiers": [ [ "species_10514676", "catalyst" ] ], "additional_components": [ "Q17693", "WBGene00015512" ] }, "reaction_10563449": { "compartment": "compartment_70101", "id": "reaction_10563449", "reactome": "R-CEL-6808496", "name": "ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_111353", "species_29366" ], "products": [ "species_70106", "species_113528", "species_29364", "species_197969" ], "modifiers": [ [ "species_10563446", "catalyst" ] ], "additional_components": [ "G5ECV9", "WBGene00000109" ] }, "reaction_10514653": { "compartment": "compartment_876", "id": "reaction_10514653", "reactome": "R-CEL-200646", "name": "Cytosolic folate export across the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_197965" ], "products": [ "species_200716" ], "modifiers": [ [ "species_10514650", "catalyst" ] ], "additional_components": [ "Q9UAZ6", "WBGene00021159", "Q9XWL3", "WBGene00012811", "H2KZC0", "WBGene00016705", "Q20236", "WBGene00009582" ] }, "reaction_10514655": { "compartment": "compartment_70101", "id": "reaction_10514655", "reactome": "R-CEL-200651", "name": "5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29424", "species_200739" ], "products": [ "species_200736", "species_197969" ], "modifiers": [ [ "species_10503873", "catalyst" ] ], "additional_components": [ "P50432", "WBGene00003214" ] }, "reaction_10507440": { "compartment": "compartment_7660", "id": "reaction_10507440", "reactome": "R-CEL-75866", "name": "Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10507428" ], "products": [ "species_10507436" ], "modifiers": [], "additional_components": [ "G5EG49", "WBGene00013998", "G5EG47", "WBGene00010054", "O44625", "WBGene00004136", "Q9NEX2", "WBGene00013736", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "species_110614", "species_29358", "species_29494", "species_29438", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q95ZS0", "WBGene00006392", "Q9GZI6", "WBGene00006387", "G5EF68", "WBGene00006386", "O45784", "WBGene00006391", "P32085", "WBGene00006542", "O61707", "WBGene00006385", "Q9NEW8", "WBGene00006389", "Q9TYN3", "WBGene00006383", "Q18265", "WBGene00016173", "Q17957", "WBGene00006397", "E9P861", "WBGene00006384", "Q20361", "WBGene00006395", "G5EGM3", "WBGene00006382", "O16991", "WBGene00006648", "G5EG49", "WBGene00013998", "G5EG47", "WBGene00010054", "O44625", "WBGene00004136", "Q9NEX2", "WBGene00013736", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q95ZS0", "WBGene00006392", "Q9GZI6", "WBGene00006387", "G5EF68", "WBGene00006386", "O45784", "WBGene00006391", "P32085", "WBGene00006542", "O61707", "WBGene00006385", "Q9NEW8", "WBGene00006389", "Q9TYN3", "WBGene00006383", "Q18265", "WBGene00016173", "Q17957", "WBGene00006397", "E9P861", "WBGene00006384", "Q20361", "WBGene00006395", "G5EGM3", "WBGene00006382", "O16991", "WBGene00006648", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529" ] }, "reaction_10507430": { "compartment": "compartment_7660", "id": "reaction_10507430", "reactome": "R-CEL-75861", "name": "NTP Binds Active Site of RNA Polymerase II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30595", "species_10507424" ], "products": [ "species_10507428" ], "modifiers": [], "additional_components": [ "species_110614", "species_29358", "species_29494", "species_29438", "G5EG49", "WBGene00013998", "G5EG47", "WBGene00010054", "O44625", "WBGene00004136", "Q9NEX2", "WBGene00013736", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q95ZS0", "WBGene00006392", "Q9GZI6", "WBGene00006387", "G5EF68", "WBGene00006386", "O45784", "WBGene00006391", "P32085", "WBGene00006542", "O61707", "WBGene00006385", "Q9NEW8", "WBGene00006389", "Q9TYN3", "WBGene00006383", "Q18265", "WBGene00016173", "Q17957", "WBGene00006397", "E9P861", "WBGene00006384", "Q20361", "WBGene00006395", "G5EGM3", "WBGene00006382", "O16991", "WBGene00006648", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "G5EG49", "WBGene00013998", "G5EG47", "WBGene00010054", "O44625", "WBGene00004136", "Q9NEX2", "WBGene00013736", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "species_110614", "species_29358", "species_29494", "species_29438", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q95ZS0", "WBGene00006392", "Q9GZI6", "WBGene00006387", "G5EF68", "WBGene00006386", "O45784", "WBGene00006391", "P32085", "WBGene00006542", "O61707", "WBGene00006385", "Q9NEW8", "WBGene00006389", "Q9TYN3", "WBGene00006383", "Q18265", "WBGene00016173", "Q17957", "WBGene00006397", "E9P861", "WBGene00006384", "Q20361", "WBGene00006395", "G5EGM3", "WBGene00006382", "O16991", "WBGene00006648" ] }, "reaction_10507438": { "compartment": "compartment_7660", "id": "reaction_10507438", "reactome": "R-CEL-75864", "name": "Newly Formed Phosphodiester Bond Stabilized and PPi Released", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10507436" ], "products": [ "species_113541", "species_10506530" ], "modifiers": [], "additional_components": [ "G5EG49", "WBGene00013998", "G5EG47", "WBGene00010054", "O44625", "WBGene00004136", "Q9NEX2", "WBGene00013736", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q95ZS0", "WBGene00006392", "Q9GZI6", "WBGene00006387", "G5EF68", "WBGene00006386", "O45784", "WBGene00006391", "P32085", "WBGene00006542", "O61707", "WBGene00006385", "Q9NEW8", "WBGene00006389", "Q9TYN3", "WBGene00006383", "Q18265", "WBGene00016173", "Q17957", "WBGene00006397", "E9P861", "WBGene00006384", "Q20361", "WBGene00006395", "G5EGM3", "WBGene00006382", "O16991", "WBGene00006648", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "G5EG49", "WBGene00013998", "G5EG47", "WBGene00010054", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "O44625", "WBGene00004136", "Q9NEX2", "WBGene00013736", "Q95ZS0", "WBGene00006392", "Q9GZI6", "WBGene00006387", "G5EF68", "WBGene00006386", "O45784", "WBGene00006391", "P32085", "WBGene00006542", "O61707", "WBGene00006385", "Q9NEW8", "WBGene00006389", "Q9TYN3", "WBGene00006383", "Q18265", "WBGene00016173", "Q17957", "WBGene00006397", "E9P861", "WBGene00006384", "Q20361", "WBGene00006395", "G5EGM3", "WBGene00006382", "O16991", "WBGene00006648", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529" ] }, "reaction_10568438": { "compartment": "compartment_7660", "id": "reaction_10568438", "reactome": "R-CEL-8938913", "name": "RUNX1 binds ELF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10566201", "species_10568434" ], "products": [ "species_10568436" ], "modifiers": [], "additional_components": [ "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "WBGene00016029", "H2KYY1", "WBGene00016029", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393" ] }, "reaction_10558118": { "compartment": "compartment_70101", "id": "reaction_10558118", "reactome": "R-CEL-6785648", "name": "MEMO1 binds RHOA:GTP:DIAPH1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10558114", "species_10554688" ], "products": [ "species_10558116" ], "modifiers": [], "additional_components": [ "Q22915", "WBGene00016500", "Q22038", "WBGene00004357", "species_29438", "Q19479", "WBGene00008848", "Q7JP75", "WBGene00000872", "Q22038", "WBGene00004357", "species_29438", "Q19479", "WBGene00008848", "Q7JP75", "WBGene00000872", "Q22915", "WBGene00016500" ] }, "reaction_10520920": { "compartment": "compartment_70101", "id": "reaction_10520920", "reactome": "R-CEL-391266", "name": "Association of CCT/TriC with sphingosine kinase 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10520872", "species_10520916" ], "products": [ "species_10520918" ], "modifiers": [], "additional_components": [ "WBGene00007918", "P46550", "WBGene00000381", "Q9TZS5", "WBGene00020391", "P47207", "WBGene00000378", "Q9N4J8", "WBGene00018782", "P47208", "WBGene00000379", "species_113582", "Q9N358", "WBGene00021934", "P47209", "WBGene00000380", "P41988", "WBGene00000377", "P46550", "WBGene00000381", "Q9TZS5", "WBGene00020391", "P47207", "WBGene00000378", "Q9N4J8", "WBGene00018782", "P47208", "WBGene00000379", "species_113582", "Q9N358", "WBGene00021934", "P47209", "WBGene00000380", "P41988", "WBGene00000377", "Q18425", "WBGene00007918" ] }, "reaction_10564273": { "compartment": "compartment_70101", "id": "reaction_10564273", "reactome": "R-CEL-6814418", "name": "PDCL promotes formation of G-beta:G-gamma heterodimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509151", "species_10564267" ], "products": [ "species_10564271" ], "modifiers": [], "additional_components": [ "P54406", "WBGene00001681", "P17343", "WBGene00001679", "Q9U1X7", "WBGene00003142", "Q9U1X7", "WBGene00003142", "P17343", "WBGene00001679", "P54406", "WBGene00001681" ] }, "reaction_10565025": { "compartment": "compartment_70101", "id": "reaction_10565025", "reactome": "R-CEL-8850560", "name": "G-protein alpha releases G-protein heterotrimer from PDCL ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10564271", "species_10508935" ], "products": [ "species_10565023", "species_10564228" ], "modifiers": [], "additional_components": [ "Q9U1X7", "WBGene00003142", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196", "P17343", "WBGene00001679", "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196", "P54406", "WBGene00001681", "WBGene00003142" ] }, "reaction_10564213": { "compartment": "compartment_70101", "id": "reaction_10564213", "reactome": "R-CEL-6814119", "name": "TRiC/CCT binds unfolded G-protein beta subunit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509163", "species_10520916" ], "products": [ "species_10564211" ], "modifiers": [], "additional_components": [ "P17343", "WBGene00001679", "P46550", "WBGene00000381", "Q9TZS5", "WBGene00020391", "P47207", "WBGene00000378", "Q9N4J8", "WBGene00018782", "P47208", "WBGene00000379", "species_113582", "Q9N358", "WBGene00021934", "P47209", "WBGene00000380", "P41988", "WBGene00000377", "P46550", "WBGene00000381", "Q9TZS5", "WBGene00020391", "P47207", "WBGene00000378", "Q9N4J8", "WBGene00018782", "P47208", "WBGene00000379", "species_113582", "Q9N358", "WBGene00021934", "P47209", "WBGene00000380", "P41988", "WBGene00000377", "P17343", "WBGene00001679" ] }, "reaction_10565013": { "compartment": "compartment_70101", "id": "reaction_10565013", "reactome": "R-CEL-8850529", "name": "RGS proteins bind GNB5 and CCT/TRiC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10565009", "species_10564993" ], "products": [ "species_10565011" ], "modifiers": [], "additional_components": [ "P49809", "WBGene00001179", "O17589", "WBGene00001145", "P46550", "WBGene00000381", "Q9TZS5", "WBGene00020391", "P47207", "WBGene00000378", "Q9N4J8", "WBGene00018782", "P47208", "WBGene00000379", "species_113582", "Q9N358", "WBGene00021934", "P47209", "WBGene00000380", "P41988", "WBGene00000377", "Q20636", "WBGene00001680", "P46550", "WBGene00000381", "Q9TZS5", "WBGene00020391", "P47207", "WBGene00000378", "Q9N4J8", "WBGene00018782", "P47208", "WBGene00000379", "species_113582", "Q9N358", "WBGene00021934", "P47209", "WBGene00000380", "P41988", "WBGene00000377", "Q20636", "WBGene00001680", "P49809", "WBGene00001179", "O17589", "WBGene00001145" ] }, "reaction_10564265": { "compartment": "compartment_70101", "id": "reaction_10564265", "reactome": "R-CEL-6814409", "name": "CK2 phosphorylates PDCL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10564263" ], "products": [ "species_29370", "species_10564228" ], "modifiers": [ [ "species_10515097", "catalyst" ] ], "additional_components": [ "WBGene00003142", "WBGene00003142", "P18334", "WBGene00002191", "P28548", "WBGene00002196" ] }, "reaction_10565017": { "compartment": "compartment_70101", "id": "reaction_10565017", "reactome": "R-CEL-8850534", "name": "PDCL promotes G-protein beta 5 folding", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10565015" ], "products": [ "species_10564228", "species_10564993" ], "modifiers": [], "additional_components": [ "P46550", "WBGene00000381", "Q9TZS5", "WBGene00020391", "P47207", "WBGene00000378", "Q9N4J8", "WBGene00018782", "P47208", "WBGene00000379", "species_113582", "Q9N358", "WBGene00021934", "P47209", "WBGene00000380", "P41988", "WBGene00000377", "Q20636", "WBGene00001680", "Q9U1X7", "WBGene00003142", "WBGene00003142", "P46550", "WBGene00000381", "Q9TZS5", "WBGene00020391", "P47207", "WBGene00000378", "Q9N4J8", "WBGene00018782", "P47208", "WBGene00000379", "species_113582", "Q9N358", "WBGene00021934", "P47209", "WBGene00000380", "P41988", "WBGene00000377", "Q20636", "WBGene00001680" ] }, "reaction_10564232": { "compartment": "compartment_70101", "id": "reaction_10564232", "reactome": "R-CEL-6814121", "name": "PDCL binds G-protein beta and TRiC/CCT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10564228", "species_10564211" ], "products": [ "species_10564230" ], "modifiers": [], "additional_components": [ "WBGene00003142", "P46550", "WBGene00000381", "Q9TZS5", "WBGene00020391", "P47207", "WBGene00000378", "Q9N4J8", "WBGene00018782", "P47208", "WBGene00000379", "species_113582", "Q9N358", "WBGene00021934", "P47209", "WBGene00000380", "P41988", "WBGene00000377", "P17343", "WBGene00001679", "P46550", "WBGene00000381", "Q9TZS5", "WBGene00020391", "P47207", "WBGene00000378", "Q9N4J8", "WBGene00018782", "P47208", "WBGene00000379", "species_113582", "Q9N358", "WBGene00021934", "P47209", "WBGene00000380", "P41988", "WBGene00000377", "P17343", "WBGene00001679", "Q9U1X7", "WBGene00003142" ] }, "reaction_10564219": { "compartment": "compartment_70101", "id": "reaction_10564219", "reactome": "R-CEL-6814120", "name": "ATP hydrolysis promotes folding of G-protein beta by TRiC/CCT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10564217" ], "products": [ "species_29372", "species_10564211" ], "modifiers": [], "additional_components": [ "P46550", "WBGene00000381", "Q9TZS5", "WBGene00020391", "P47207", "WBGene00000378", "Q9N4J8", "WBGene00018782", "P47208", "WBGene00000379", "species_29358", "Q9N358", "WBGene00021934", "P47209", "WBGene00000380", "P41988", "WBGene00000377", "P17343", "WBGene00001679", "P46550", "WBGene00000381", "Q9TZS5", "WBGene00020391", "P47207", "WBGene00000378", "Q9N4J8", "WBGene00018782", "P47208", "WBGene00000379", "species_113582", "Q9N358", "WBGene00021934", "P47209", "WBGene00000380", "P41988", "WBGene00000377", "P17343", "WBGene00001679" ] }, "reaction_10564234": { "compartment": "compartment_70101", "id": "reaction_10564234", "reactome": "R-CEL-6814124", "name": "ATP binds G-protein beta associated TRiC/CCT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10564211" ], "products": [ "species_29370", "species_10564217" ], "modifiers": [], "additional_components": [ "P46550", "WBGene00000381", "Q9TZS5", "WBGene00020391", "P47207", "WBGene00000378", "Q9N4J8", "WBGene00018782", "P47208", "WBGene00000379", "species_113582", "Q9N358", "WBGene00021934", "P47209", "WBGene00000380", "P41988", "WBGene00000377", "P17343", "WBGene00001679", "P46550", "WBGene00000381", "Q9TZS5", "WBGene00020391", "P47207", "WBGene00000378", "Q9N4J8", "WBGene00018782", "P47208", "WBGene00000379", "species_29358", "Q9N358", "WBGene00021934", "P47209", "WBGene00000380", "P41988", "WBGene00000377", "P17343", "WBGene00001679" ] }, "reaction_10565021": { "compartment": "compartment_70101", "id": "reaction_10565021", "reactome": "R-CEL-8850539", "name": "Release of GNB5:RGS dimers from CCT/TRiC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10565011" ], "products": [ "species_10565019", "species_10520916" ], "modifiers": [], "additional_components": [ "P46550", "WBGene00000381", "Q9TZS5", "WBGene00020391", "P47207", "WBGene00000378", "Q9N4J8", "WBGene00018782", "P47208", "WBGene00000379", "species_113582", "Q9N358", "WBGene00021934", "P47209", "WBGene00000380", "P41988", "WBGene00000377", "Q20636", "WBGene00001680", "P49809", "WBGene00001179", "O17589", "WBGene00001145", "P49809", "WBGene00001179", "O17589", "WBGene00001145", "Q20636", "WBGene00001680", "P46550", "WBGene00000381", "Q9TZS5", "WBGene00020391", "P47207", "WBGene00000378", "Q9N4J8", "WBGene00018782", "P47208", "WBGene00000379", "species_113582", "Q9N358", "WBGene00021934", "P47209", "WBGene00000380", "P41988", "WBGene00000377" ] }, "reaction_10564991": { "compartment": "compartment_70101", "id": "reaction_10564991", "reactome": "R-CEL-8850527", "name": "PDCL releases folded G-beta from TRiC/CCT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10564989" ], "products": [ "species_10564267", "species_10520916" ], "modifiers": [], "additional_components": [ "Q9U1X7", "WBGene00003142", "P46550", "WBGene00000381", "Q9TZS5", "WBGene00020391", "P47207", "WBGene00000378", "Q9N4J8", "WBGene00018782", "P47208", "WBGene00000379", "species_113582", "Q9N358", "WBGene00021934", "P47209", "WBGene00000380", "P41988", "WBGene00000377", "P17343", "WBGene00001679", "P17343", "WBGene00001679", "Q9U1X7", "WBGene00003142", "P46550", "WBGene00000381", "Q9TZS5", "WBGene00020391", "P47207", "WBGene00000378", "Q9N4J8", "WBGene00018782", "P47208", "WBGene00000379", "species_113582", "Q9N358", "WBGene00021934", "P47209", "WBGene00000380", "P41988", "WBGene00000377" ] }, "reaction_10524242": { "compartment": "compartment_876", "id": "reaction_10524242", "reactome": "R-CEL-437300", "name": "SLC31A1 transports Cu2+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_437295" ], "products": [ "species_209799" ], "modifiers": [ [ "species_10524239", "catalyst" ] ], "additional_components": [ "WBGene00017852" ] }, "reaction_10524450": { "compartment": "compartment_876", "id": "reaction_10524450", "reactome": "R-CEL-442661", "name": "SLC41A1,2 transport Mg2+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_114632" ], "products": [ "species_29926" ], "modifiers": [ [ "species_10524447", "catalyst" ] ], "additional_components": [ "O02340", "WBGene00022682", "O44196", "WBGene00022682", "O45182", "WBGene00022682" ] }, "reaction_10524215": { "compartment": "compartment_1462052", "id": "reaction_10524215", "reactome": "R-CEL-437085", "name": "ZnT5 transports zinc into secretory granules in pancreatic beta cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29426" ], "products": [ "species_216785" ], "modifiers": [ [ "species_10524212", "catalyst" ] ], "additional_components": [ "WBGene00013668" ] }, "reaction_10524231": { "compartment": "compartment_20699", "id": "reaction_10524231", "reactome": "R-CEL-437139", "name": "ZnT6 transports zinc into the golgi apparatus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29426" ], "products": [ "species_216667" ], "modifiers": [ [ "species_10524228", "catalyst" ] ], "additional_components": [ "WBGene00006590" ] }, "reaction_10524207": { "compartment": "compartment_876", "id": "reaction_10524207", "reactome": "R-CEL-435366", "name": "ZnT1 mediates the efflux of zinc from the cell", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29426" ], "products": [ "species_158417" ], "modifiers": [ [ "species_10524204", "catalyst" ] ], "additional_components": [ "WBGene00000393" ] }, "reaction_10524223": { "compartment": "compartment_20699", "id": "reaction_10524223", "reactome": "R-CEL-437136", "name": "SLC30A8 transports Zn2+ from cytosol to secretory granule", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29426" ], "products": [ "species_216785" ], "modifiers": [ [ "species_10524220", "catalyst" ] ], "additional_components": [ "WBGene00011821" ] }, "reaction_10524385": { "compartment": "compartment_12045", "id": "reaction_10524385", "reactome": "R-CEL-442393", "name": "ZIP7 mediates zinc efflux from the endoplasmic reticulum", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_442320" ], "products": [ "species_29426" ], "modifiers": [ [ "species_10524382", "catalyst" ] ], "additional_components": [ "WBGene00006494" ] }, "reaction_10524344": { "compartment": "compartment_876", "id": "reaction_10524344", "reactome": "R-CEL-442317", "name": "ZIP6 and ZIP14 mediate zinc influx into cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158417" ], "products": [ "species_29426" ], "modifiers": [ [ "species_10524341", "catalyst" ] ], "additional_components": [ "U4PS08", "WBGene00021936", "Q22395", "WBGene00006486" ] }, "reaction_10524377": { "compartment": "compartment_876", "id": "reaction_10524377", "reactome": "R-CEL-442387", "name": "ZIP8 mediates zinc influx into cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158417" ], "products": [ "species_29426" ], "modifiers": [ [ "species_10524374", "catalyst" ] ], "additional_components": [ "Q22395", "WBGene00006486", "U4PS08", "WBGene00021936" ] }, "reaction_10524426": { "compartment": "compartment_876", "id": "reaction_10524426", "reactome": "R-CEL-442422", "name": "SLC39A1-4 transports Zn2+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158417" ], "products": [ "species_29426" ], "modifiers": [ [ "species_10524423", "catalyst" ] ], "additional_components": [ "Q09957", "WBGene00015940", "U4PS08", "WBGene00021936", "P91348", "WBGene00018897", "Q19913", "WBGene00017936", "Q6BEU0", "WBGene00014669", "O62192", "WBGene00009286", "Q9XWH3", "WBGene00013207" ] }, "reaction_10524199": { "compartment": "compartment_876", "id": "reaction_10524199", "reactome": "R-CEL-435349", "name": "SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_435347" ], "products": [ "species_70106", "species_71067" ], "modifiers": [ [ "species_10524196", "catalyst" ] ], "additional_components": [ "WBGene00004876" ] }, "reaction_10570186": { "compartment": "compartment_70101", "id": "reaction_10570186", "reactome": "R-CEL-8959798", "name": "SLC30A10 transports Mn2+ from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29418" ], "products": [ "species_266099" ], "modifiers": [ [ "species_10570183", "catalyst" ] ], "additional_components": [ "WBGene00000393" ] }, "reaction_10524366": { "compartment": "compartment_876", "id": "reaction_10524366", "reactome": "R-CEL-442368", "name": "SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71067" ], "products": [ "species_435347" ], "modifiers": [ [ "species_10524363", "catalyst" ] ], "additional_components": [ "O44607", "WBGene00019977", "Q8IA95", "WBGene00021354", "CHEBI:28694", "Q19687", "WBGene00009008" ] }, "reaction_10528430": { "compartment": "compartment_876", "id": "reaction_10528430", "reactome": "R-CEL-904830", "name": "SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71067" ], "products": [ "species_435347" ], "modifiers": [ [ "species_10528427", "catalyst" ] ], "additional_components": [ "Q19687", "WBGene00009008", "species_209799", "O44607", "WBGene00019977", "Q8IA95", "WBGene00021354" ] }, "reaction_10507115": { "compartment": "compartment_7660", "id": "reaction_10507115", "reactome": "R-CEL-75079", "name": "Formation of AT-AC C complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10507111" ], "products": [ "species_10507103", "species_10507113" ], "modifiers": [], "additional_components": [ "Q17348", "WBGene00004914", "Q9N4G9", "WBGene00004920", "Q18786", "WBGene00004917", "P91918", "WBGene00004915", "Q9XTU6", "WBGene00004919", "Q10013", "WBGene00004916", "P34659", "WBGene00004918", "Q23463", "WBGene00001166", "O02097", "WBGene00015974", "P92022", "WBGene00001808", "Q21568", "WBGene00010896", "Q9U2G0", "WBGene00012896", "Q95QN2", "WBGene00017162", "P34369", "WBGene00004187", "Q9GRZ2", "WBGene00013343", "L8E6I4", "WBGene00235102", "Q23120", "WBGene00004699", "Q9NEW6", "WBGene00004700", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "Q09511", "WBGene00004701", "O44985", "WBGene00019323", "G5EEQ8", "WBGene00011605", "Q8ITY4", "WBGene00016808", "O16997", "WBGene00021004", "Q93382", "WBGene00008119", "P91306", "WBGene00000473", "Q17348", "WBGene00004914", "Q9N4G9", "WBGene00004920", "Q18786", "WBGene00004917", "P91918", "WBGene00004915", "Q9XTU6", "WBGene00004919", "Q10013", "WBGene00004916", "P34659", "WBGene00004918", "Q23120", "WBGene00004699", "Q9NEW6", "WBGene00004700", "Q17348", "WBGene00004914", "Q9N4G9", "WBGene00004920", "Q18786", "WBGene00004917", "P91918", "WBGene00004915", "Q9XTU6", "WBGene00004919", "Q10013", "WBGene00004916", "P34659", "WBGene00004918", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "Q09511", "WBGene00004701", "O44985", "WBGene00019323", "G5EEQ8", "WBGene00011605", "Q8ITY4", "WBGene00016808", "O16997", "WBGene00021004", "Q93382", "WBGene00008119", "P91306", "WBGene00000473", "Q23463", "WBGene00001166", "O02097", "WBGene00015974", "P92022", "WBGene00001808", "Q21568", "WBGene00010896", "Q9U2G0", "WBGene00012896", "Q95QN2", "WBGene00017162", "P34369", "WBGene00004187", "Q9GRZ2", "WBGene00013343", "L8E6I4", "WBGene00235102" ] }, "reaction_10507117": { "compartment": "compartment_7660", "id": "reaction_10507117", "reactome": "R-CEL-75082", "name": "ATAC spliceosome mediated Lariat formation,5' splice site cleavage", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10507113" ], "products": [ "species_10507113" ], "modifiers": [], "additional_components": [ "Q23120", "WBGene00004699", "Q9NEW6", "WBGene00004700", "Q17348", "WBGene00004914", "Q9N4G9", "WBGene00004920", "Q18786", "WBGene00004917", "P91918", "WBGene00004915", "Q9XTU6", "WBGene00004919", "Q10013", "WBGene00004916", "P34659", "WBGene00004918", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "Q09511", "WBGene00004701", "O44985", "WBGene00019323", "G5EEQ8", "WBGene00011605", "Q8ITY4", "WBGene00016808", "O16997", "WBGene00021004", "Q93382", "WBGene00008119", "P91306", "WBGene00000473", "Q23463", "WBGene00001166", "O02097", "WBGene00015974", "P92022", "WBGene00001808", "Q21568", "WBGene00010896", "Q9U2G0", "WBGene00012896", "Q95QN2", "WBGene00017162", "P34369", "WBGene00004187", "Q9GRZ2", "WBGene00013343", "L8E6I4", "WBGene00235102", "Q23120", "WBGene00004699", "Q9NEW6", "WBGene00004700", "Q17348", "WBGene00004914", "Q9N4G9", "WBGene00004920", "Q18786", "WBGene00004917", "P91918", "WBGene00004915", "Q9XTU6", "WBGene00004919", "Q10013", "WBGene00004916", "P34659", "WBGene00004918", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "Q09511", "WBGene00004701", "O44985", "WBGene00019323", "G5EEQ8", "WBGene00011605", "Q8ITY4", "WBGene00016808", "O16997", "WBGene00021004", "Q93382", "WBGene00008119", "P91306", "WBGene00000473", "Q23463", "WBGene00001166", "O02097", "WBGene00015974", "P92022", "WBGene00001808", "Q21568", "WBGene00010896", "Q9U2G0", "WBGene00012896", "Q95QN2", "WBGene00017162", "P34369", "WBGene00004187", "Q9GRZ2", "WBGene00013343", "L8E6I4", "WBGene00235102" ] }, "reaction_10505265": { "compartment": "compartment_7660", "id": "reaction_10505265", "reactome": "R-CEL-72139", "name": "Formation of the active Spliceosomal C (B*) complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10505258" ], "products": [ "species_10505262", "species_10505252" ], "modifiers": [ [ "species_10505258", "catalyst" ] ], "additional_components": [ "P34313", "WBGene00007400", "P91306", "WBGene00000473", "Q9U1Q7", "WBGene00001258", "Q18265", "WBGene00016173", "Q22307", "WBGene00004355", "Q17336", "WBGene00002957", "Q18409", "WBGene00004703", "Q9NEW6", "WBGene00004700", "Q22412", "WBGene00011722", "Q23120", "WBGene00004699", "Q966L5", "WBGene00017085", "Q965K2", "WBGene00018776", "Q21322", "WBGene00004385", "Q21323", "WBGene00004386", "Q20875", "WBGene00018967", "Q9N3S4", "WBGene00004389", "Q20966", "WBGene00010233", "O44985", "WBGene00019323", "G5EEQ8", "WBGene00011605", "Q8ITY4", "WBGene00016808", "O16997", "WBGene00021004", "Q93382", "WBGene00008119", "Q22469", "WBGene00011758", "G5ECL3", "WBGene00004188", "Q19335", "WBGene00008683", "Q95Y51", "WBGene00004891", "G5EBY6", "WBGene00004016", "Q9BLB6", "WBGene00003390", "Q95YF1", "WBGene00015581", "Q17348", "WBGene00004914", "Q9N4G9", "WBGene00004920", "Q18786", "WBGene00004917", "P91918", "WBGene00004915", "Q9XTU6", "WBGene00004919", "Q10013", "WBGene00004916", "P34659", "WBGene00004918", "G5ED97", "WBGene00006442", "Q18535", "WBGene00008034", "Q9U2S6", "WBGene00000889", "P52009", "WBGene00000877", "P52016", "WBGene00000884", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "Q21155", "WBGene00004388", "Q21559", "WBGene00000122", "B9WRU1", "WBGene00012769", "Q9NAH3", "WBGene00006563", "Q20716", "WBGene00009966", "Q9BIC2", "WBGene00020346", "G5EBT5", "WBGene00003391", "Q18445", "WBGene00000888", "Q21924", "WBGene00011237", "O45244", "WBGene00003392", "Q9BL61", "WBGene00022029", "Q95Y44", "WBGene00001048", "Q95PY8", "WBGene00013460", "U4PCM1", "WBGene00011051", "Q9N4C2", "WBGene00022301", "Q7YTG9", "WBGene00044329", "O17403", "WBGene00017313", "O16929", "WBGene00017797", "O45577", "WBGene00000774", "Q19864", "WBGene00000773", "Q19866", "WBGene00006307", "Q09995", "WBGene00011791", "Q9U2P3", "WBGene00012528", "G5EBX5", "WBGene00009658", "P52874", "WBGene00010304", "Q09345", "WBGene00020092", "Q93233", "WBGene00003904", "Q93716", "WBGene00009668", "C1P629", "WBGene00008362", "O44729", "WBGene00018625", "P91175", "WBGene00016837", "O62185", "WBGene00004706", "P34498", "WBGene00003389", "Q22836", "WBGene00004806", "Q23463", "WBGene00001166", "O02097", "WBGene00015974", "P92022", "WBGene00001808", "Q21568", "WBGene00010896", "Q9U2G0", "WBGene00012896", "Q95QN2", "WBGene00017162", "P34369", "WBGene00004187", 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10505118", "species_10505086", "species_10505054", "species_10505081", "species_10505049", "species_10505076", "species_10505044", "species_10505039", "species_10505101", "species_10504909", "species_10505096", "species_10505091", "species_10505059" ], "products": [ "species_10504719", "species_10505120" ], "modifiers": [], "additional_components": [ "Q18445", "WBGene00000888", "WBGene00011722", "WBGene00019762", "WBGene00008034", "WBGene00007400", "Q9U2S6", "WBGene00000889", "P52009", "WBGene00000877", "P52016", "WBGene00000884", "WBGene00001258", "O01524", "WBGene00017605", "Q95XD4", "WBGene00003082", "O18694", "WBGene00003079", "P92022", "WBGene00001808", "Q95XN6", "WBGene00003080", "Q9U1W8", "WBGene00003077", "Q23543", "WBGene00003081", "Q19952", "WBGene00003078", "Q21568", "WBGene00010896", "Q93339", "WBGene00007972", "P52018", "WBGene00000887", "Q21486", "WBGene00010844", "Q17348", 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from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10505213", "species_10505197", "species_10505225", "species_10505192", "species_10505175", "species_10505156" ], "products": [ "species_10505227" ], "modifiers": [], "additional_components": [ "Q93716", "WBGene00009668", "C1P629", "WBGene00008362", "WBGene00003904", "P52874", "WBGene00010304", "Q09345", "WBGene00020092", "Q09995", "WBGene00011791", "Q9U2P3", "WBGene00012528", "G5EBX5", "WBGene00009658", "O45577", "WBGene00000774", "Q19864", "WBGene00000773", "Q19866", "WBGene00006307", "Q95PY8", "WBGene00013460", "U4PCM1", "WBGene00011051", "Q9N4C2", "WBGene00022301", "Q7YTG9", "WBGene00044329", "O17403", "WBGene00017313", "O16929", "WBGene00017797", "Q95PY8", "WBGene00013460", "U4PCM1", "WBGene00011051", "Q9N4C2", "WBGene00022301", "Q7YTG9", "WBGene00044329", "O17403", "WBGene00017313", "O16929", "WBGene00017797", "O45577", "WBGene00000774", "Q19864", "WBGene00000773", "Q19866", "WBGene00006307", "Q09995", "WBGene00011791", "Q9U2P3", "WBGene00012528", "G5EBX5", "WBGene00009658", "P52874", "WBGene00010304", "Q09345", "WBGene00020092", "Q93233", "WBGene00003904", "Q93716", "WBGene00009668", "C1P629", "WBGene00008362" ] }, "reaction_10505260": { "compartment": "compartment_7660", "id": "reaction_10505260", "reactome": "R-CEL-72130", "name": "Formation of an intermediate Spliceosomal C (Bact) complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10505247", "species_10505227", "species_10505242", "species_10505237", "species_10505252", "species_10505232", "species_10505120" ], "products": [ "species_10505101", "species_10505037", "species_10504940", "species_10504907", "species_10505258", "species_10505032", "species_10504979", "species_10505027", "species_10504608" ], "modifiers": [], "additional_components": [ "WBGene00003391", "Q95PY8", "WBGene00013460", "U4PCM1", "WBGene00011051", "Q9N4C2", "WBGene00022301", "Q7YTG9", "WBGene00044329", "O17403", "WBGene00017313", "O16929", "WBGene00017797", "O45577", "WBGene00000774", "Q19864", "WBGene00000773", "Q19866", "WBGene00006307", "Q09995", "WBGene00011791", "Q9U2P3", "WBGene00012528", "G5EBX5", "WBGene00009658", "P52874", "WBGene00010304", "Q09345", "WBGene00020092", "Q93233", "WBGene00003904", "Q93716", "WBGene00009668", "C1P629", "WBGene00008362", "WBGene00011237", "WBGene00003392", "WBGene00000892", "WBGene00022029", "Q17336", "WBGene00002957", "Q18409", "WBGene00004703", "Q9U304", "WBGene00013703", "Q8MXR2", "WBGene00022253", "Q9BIB7", "WBGene00020936", "Q9NEW6", "WBGene00004700", "P34307", "WBGene00015557", "Q95Y67", "WBGene00003978", "Q22412", "WBGene00011722", "Q23120", "WBGene00004699", "Q966L5", "WBGene00017085", "Q965K2", "WBGene00018776", "Q21322", "WBGene00004385", "Q21323", "WBGene00004386", "Q20875", "WBGene00018967", "Q9N3S4", "WBGene00004389", "Q20966", "WBGene00010233", "O44985", "WBGene00019323", "G5EEQ8", "WBGene00011605", "Q8ITY4", "WBGene00016808", "O16997", "WBGene00021004", "Q93382", "WBGene00008119", "Q22469", "WBGene00011758", "G5ECL3", "WBGene00004188", "Q19335", "WBGene00008683", "Q95Y51", "WBGene00004891", "G5EBY6", "WBGene00004016", "Q9BLB6", "WBGene00003390", "Q95YF1", "WBGene00015581", "Q17348", "WBGene00004914", "Q9N4G9", "WBGene00004920", "Q18786", "WBGene00004917", "P91918", "WBGene00004915", "Q9XTU6", "WBGene00004919", "Q10013", "WBGene00004916", "P34659", "WBGene00004918", "G5ED97", "WBGene00006442", "Q18535", "WBGene00008034", "Q9XUW5", "WBGene00010260", "Q9U2S6", "WBGene00000889", "P52009", "WBGene00000877", "P52016", "WBGene00000884", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "Q21155", "WBGene00004388", "Q21559", "WBGene00000122", "B9WRU1", "WBGene00012769", "Q9NAH3", "WBGene00006563", "Q20716", "WBGene00009966", "Q19614", "WBGene00017620", "Q9BIC2", "WBGene00020346", "Q18445", "WBGene00000888", "P34541", "WBGene00019881", "Q4W5P0", "WBGene00022235", "Q95Y44", "WBGene00001048", "Q18942", "WBGene00008380", 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"WBGene00008034", "Q9U2S6", "WBGene00000889", "P52009", "WBGene00000877", "P52016", "WBGene00000884", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "Q21155", "WBGene00004388", "Q21559", "WBGene00000122", "B9WRU1", "WBGene00012769", "Q9NAH3", "WBGene00006563", "Q20716", "WBGene00009966", "Q9BIC2", "WBGene00020346", "G5EBT5", "WBGene00003391", "Q18445", "WBGene00000888", "Q21924", "WBGene00011237", "O45244", "WBGene00003392", "Q9BL61", "WBGene00022029", "Q95Y44", "WBGene00001048", "Q95PY8", "WBGene00013460", "U4PCM1", "WBGene00011051", "Q9N4C2", "WBGene00022301", "Q7YTG9", "WBGene00044329", 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"WBGene00004919", "Q10013", "WBGene00004916", "P34659", "WBGene00004918", "Q09584", "WBGene00004390", "P90815", "WBGene00017238" ] }, "reaction_10509836": { "compartment": "compartment_7660", "id": "reaction_10509836", "reactome": "R-CEL-156661", "name": "Formation of Exon Junction Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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"WBGene00004916", "P34659", "WBGene00004918", "G5ED97", "WBGene00006442", "Q18535", "WBGene00008034", "Q9U2S6", "WBGene00000889", "P52009", "WBGene00000877", "P52016", "WBGene00000884", "Q21155", "WBGene00004388", "Q21559", "WBGene00000122", "B9WRU1", "WBGene00012769", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q9NAH3", "WBGene00006563", "Q20716", "WBGene00009966", "Q9BIC2", "WBGene00020346", "G5EBT5", "WBGene00003391", "Q18445", "WBGene00000888", "Q21924", "WBGene00011237", "O45244", "WBGene00003392", "Q95Y44", "WBGene00001048", "Q95PY8", "WBGene00013460", "U4PCM1", "WBGene00011051", "Q9N4C2", "WBGene00022301", "Q7YTG9", "WBGene00044329", "O17403", "WBGene00017313", "O16929", "WBGene00017797", "O45577", "WBGene00000774", "Q19864", "WBGene00000773", "Q19866", "WBGene00006307", "Q09995", "WBGene00011791", "Q9U2P3", "WBGene00012528", "G5EBX5", "WBGene00009658", "P52874", "WBGene00010304", "Q09345", "WBGene00020092", "Q93233", "WBGene00003904", "Q93716", "WBGene00009668", "C1P629", "WBGene00008362", "O44729", "WBGene00018625", "P91175", "WBGene00016837", "O62185", "WBGene00004706", "P34498", "WBGene00003389", "Q22836", "WBGene00004806", "Q23463", "WBGene00001166", "O02097", "WBGene00015974", "P92022", "WBGene00001808", "Q21568", "WBGene00010896", "Q9U2G0", "WBGene00012896", "Q95QN2", "WBGene00017162", "P34369", "WBGene00004187", "Q9GRZ2", "WBGene00013343", "L8E6I4", "WBGene00235102", "Q09385", "WBGene00019402", "Q10051", "WBGene00020423", "O45766", "WBGene00011687", "Q22417", "WBGene00020441", "O16786", "WBGene00020647", "P09446", "WBGene00002005", "G5EFC4", "WBGene00008386", "Q09556", "WBGene00009364", "G5EEL2", "WBGene00006481", "P91401", "WBGene00019711", "Q9XTZ2", "WBGene00004705", "Q8WQF3", "WBGene00004882", "Q09511", "WBGene00004701", "Q9U2U0", "WBGene00006698", "P34541", "WBGene00019881", "Q4W5P0", "WBGene00022235", "Q9U304", "WBGene00013703", "Q8MXR2", "WBGene00022253", "Q9BIB7", "WBGene00020936", "Q19614", "WBGene00017620", "P34307", "WBGene00015557", "Q95Y67", "WBGene00003978", "P91277", "WBGene00017816", "Q18999", "WBGene00004207", "Q95QR5", "WBGene00016624", "Q9XVS2", "WBGene00045383", "Q9NLD1", "WBGene00002000", "Q9XUW5", "WBGene00010260", "P90978", "WBGene00006697", "P91306", "WBGene00000473", "P34313", "WBGene00007400", "A0A0S4XR43", "Y37A1B.1a", "A9D4S6", "WBGene00019762" ] }, "reaction_10509984": { "compartment": "compartment_7660", "id": "reaction_10509984", "reactome": "R-CEL-159101", "name": "NXF1:NXT1 (TAP:p15) binds capped mRNA:CBC:EJC:TREX (minus DDX39B)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10505377", "species_10507168" ], "products": [ "species_113550", "species_10509981", "species_10509975" ], "modifiers": [ [ "species_10505377", "catalyst" ] ], "additional_components": [ "Q9NEW6", "WBGene00004700", "O62185", "WBGene00004706", "Q21155", "WBGene00004388", "Q8WQF3", "WBGene00004882", "Q21559", "WBGene00000122", "Q9BL61", "WBGene00022029", "G5EDE4", "WBGene00012343", "Q21832", "WBGene00004387", "P49029", "WBGene00003123", "P34498", "WBGene00003389", "P90978", "WBGene00006697", "Q18409", "WBGene00004703", "O44729", "WBGene00018625", "Q9U2U0", "WBGene00006698", "Q23120", "WBGene00004699", "Q09511", "WBGene00004701", "P91867", "WBGene00009341", "C2BR94", "WBGene00021311", "Q9N5E3", "WBGene00020172", "Q18033", "WBGene00015813", "Q9U3S3", "WBGene00007195", "Q9N3G0", "WBGene00021813", "Q18212", "WBGene00001840", "species_29358", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "Q21278", "WBGene00010629", "Q9U757", "WBGene00003836", "Q9XVS8", "WBGene00003835", "Q9XVS7", "WBGene00003834", "Q9U757", "WBGene00003836", "Q9XVS8", "WBGene00003835", "Q9XVS7", "WBGene00003834", "O62185", "WBGene00004706", "Q21155", "WBGene00004388", "Q8WQF3", "WBGene00004882", "Q21559", "WBGene00000122", "Q9BL61", "WBGene00022029", "G5EDE4", "WBGene00012343", "Q21832", "WBGene00004387", "P49029", "WBGene00003123", "Q9NEW6", "WBGene00004700", "P34498", "WBGene00003389", "P90978", "WBGene00006697", "Q18409", "WBGene00004703", "O44729", "WBGene00018625", "Q9U2U0", "WBGene00006698", "Q23120", "WBGene00004699", "Q09511", "WBGene00004701", "P91867", "WBGene00009341", "C2BR94", "WBGene00021311", "Q9N5E3", "WBGene00020172", "Q18033", "WBGene00015813", "Q9U3S3", "WBGene00007195", "Q9N3G0", "WBGene00021813", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "Q21278", "WBGene00010629", "Q18212", "WBGene00001840", "species_113582", "Q9NEW6", "WBGene00004700", "O62185", "WBGene00004706", "Q21155", "WBGene00004388", "Q8WQF3", "WBGene00004882", "Q21559", "WBGene00000122", "Q9BL61", "WBGene00022029", "G5EDE4", "WBGene00012343", "Q21832", "WBGene00004387", "P49029", "WBGene00003123", "P34498", "WBGene00003389", "P90978", "WBGene00006697", "Q18409", "WBGene00004703", "O44729", "WBGene00018625", "Q9U2U0", "WBGene00006698", "Q23120", "WBGene00004699", "Q09511", "WBGene00004701", "P91867", "WBGene00009341", "C2BR94", "WBGene00021311", "Q9N5E3", "WBGene00020172", "Q18033", "WBGene00015813", "Q9U3S3", "WBGene00007195", "Q9N3G0", "WBGene00021813", "Q18212", "WBGene00001840", "species_29358", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "Q21278", "WBGene00010629" ] }, "reaction_10505380": { "compartment": "compartment_7660", "id": "reaction_10505380", "reactome": "R-CEL-72185", "name": "mRNA polyadenylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10505370" ], "products": [ "species_10505197", "species_10505192", "species_10505156", "species_10505377" ], "modifiers": [ [ "species_10505192", "catalyst" ] ], "additional_components": [ "Q9NEW6", "WBGene00004700", "O62185", "WBGene00004706", "Q21155", "WBGene00004388", "Q8WQF3", "WBGene00004882", "Q21559", "WBGene00000122", "Q9BL61", "WBGene00022029", "G5EDE4", "WBGene00012343", "Q21832", "WBGene00004387", "P49029", "WBGene00003123", "P34498", "WBGene00003389", "Q95PY8", "WBGene00013460", "U4PCM1", "WBGene00011051", "Q9N4C2", "WBGene00022301", "Q7YTG9", "WBGene00044329", "O17403", "WBGene00017313", "O16929", "WBGene00017797", "P90978", "WBGene00006697", "Q18409", "WBGene00004703", "Q09995", "WBGene00011791", "Q9U2P3", "WBGene00012528", "G5EBX5", "WBGene00009658", "O44729", "WBGene00018625", "Q9U2U0", "WBGene00006698", "Q93233", "WBGene00003904", "Q23120", "WBGene00004699", "Q09511", "WBGene00004701", "P91867", "WBGene00009341", "C2BR94", "WBGene00021311", "Q9N5E3", "WBGene00020172", "Q18033", "WBGene00015813", "Q9U3S3", "WBGene00007195", "Q9N3G0", "WBGene00021813", "Q18212", "WBGene00001840", "species_29358", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "Q21278", "WBGene00010629", "WBGene00003904", "Q09995", "WBGene00011791", "Q9U2P3", "WBGene00012528", "G5EBX5", "WBGene00009658", "Q95PY8", "WBGene00013460", "U4PCM1", "WBGene00011051", "Q9N4C2", "WBGene00022301", "Q7YTG9", "WBGene00044329", "O17403", "WBGene00017313", "O16929", "WBGene00017797", "Q9NEW6", "WBGene00004700", "O62185", "WBGene00004706", "Q21155", "WBGene00004388", "Q8WQF3", "WBGene00004882", "Q21559", "WBGene00000122", "Q9BL61", "WBGene00022029", "G5EDE4", "WBGene00012343", "Q21832", "WBGene00004387", "P49029", "WBGene00003123", "P34498", "WBGene00003389", "P90978", "WBGene00006697", "Q18409", "WBGene00004703", "O44729", "WBGene00018625", "Q9U2U0", "WBGene00006698", "Q23120", "WBGene00004699", "Q09511", "WBGene00004701", "P91867", "WBGene00009341", "C2BR94", "WBGene00021311", "Q9N5E3", "WBGene00020172", "Q18033", "WBGene00015813", "Q9U3S3", "WBGene00007195", "Q9N3G0", "WBGene00021813", "Q18212", "WBGene00001840", "species_29358", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "Q21278", "WBGene00010629", "Q09995", "WBGene00011791", "Q9U2P3", "WBGene00012528", "G5EBX5", "WBGene00009658" ] }, "reaction_10505375": { "compartment": "compartment_7660", "id": "reaction_10505375", "reactome": "R-CEL-72180", "name": "Cleavage of mRNA at the 3'-end", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10505368" ], "products": [ "species_10505213", "species_10505370", "species_10505225", "species_10505175" ], "modifiers": [ [ "species_10505372", "catalyst" ] ], "additional_components": [ "Q9NEW6", "WBGene00004700", "O62185", "WBGene00004706", "Q21155", "WBGene00004388", "Q8WQF3", "WBGene00004882", "Q21559", "WBGene00000122", "Q9BL61", "WBGene00022029", "G5EDE4", "WBGene00012343", "Q21832", "WBGene00004387", "P49029", "WBGene00003123", "P34498", "WBGene00003389", "P90978", "WBGene00006697", "Q18409", "WBGene00004703", "O44729", "WBGene00018625", "Q9U2U0", "WBGene00006698", "Q95PY8", "WBGene00013460", "U4PCM1", "WBGene00011051", "Q9N4C2", "WBGene00022301", "Q7YTG9", "WBGene00044329", "O17403", "WBGene00017313", "O16929", "WBGene00017797", "O45577", "WBGene00000774", "Q19864", "WBGene00000773", "Q19866", "WBGene00006307", "Q09995", "WBGene00011791", "Q9U2P3", "WBGene00012528", "G5EBX5", "WBGene00009658", "P52874", "WBGene00010304", "Q09345", "WBGene00020092", "Q93233", "WBGene00003904", "Q93716", "WBGene00009668", "C1P629", "WBGene00008362", "Q23120", "WBGene00004699", "Q09511", "WBGene00004701", "P91867", "WBGene00009341", "C2BR94", "WBGene00021311", "Q9N5E3", "WBGene00020172", "Q18033", "WBGene00015813", "Q9U3S3", "WBGene00007195", "Q9N3G0", "WBGene00021813", "Q18212", "WBGene00001840", "species_29358", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "Q21278", "WBGene00010629", "Q93716", "WBGene00009668", "C1P629", "WBGene00008362", "Q9NEW6", "WBGene00004700", "O62185", "WBGene00004706", "Q21155", "WBGene00004388", "Q8WQF3", "WBGene00004882", "Q21559", "WBGene00000122", "Q9BL61", "WBGene00022029", "G5EDE4", "WBGene00012343", "Q21832", "WBGene00004387", "P49029", "WBGene00003123", "P34498", "WBGene00003389", "Q95PY8", "WBGene00013460", "U4PCM1", "WBGene00011051", "Q9N4C2", "WBGene00022301", "Q7YTG9", "WBGene00044329", "O17403", "WBGene00017313", "O16929", "WBGene00017797", "P90978", "WBGene00006697", "Q18409", "WBGene00004703", "Q09995", "WBGene00011791", "Q9U2P3", "WBGene00012528", "G5EBX5", "WBGene00009658", "O44729", "WBGene00018625", "Q9U2U0", "WBGene00006698", "Q93233", "WBGene00003904", "Q23120", "WBGene00004699", "Q09511", "WBGene00004701", "P91867", "WBGene00009341", "C2BR94", "WBGene00021311", "Q9N5E3", "WBGene00020172", "Q18033", "WBGene00015813", "Q9U3S3", "WBGene00007195", "Q9N3G0", "WBGene00021813", "Q18212", "WBGene00001840", "species_29358", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "Q21278", "WBGene00010629", "P52874", "WBGene00010304", "Q09345", "WBGene00020092", "O45577", "WBGene00000774", "Q19864", "WBGene00000773", "Q19866", "WBGene00006307", "P52874", "WBGene00010304", "Q09345", "WBGene00020092", "Q93716", "WBGene00009668", "C1P629", "WBGene00008362" ] }, "reaction_10553705": { "compartment": "compartment_18730", "id": "reaction_10553705", "reactome": "R-CEL-5625426", "name": "Retrograde IFT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10553703" ], "products": [ "species_10553699" ], "modifiers": [], "additional_components": [ "species_29420", "species_29438", "Q19542", "WBGene00000485", "Q18263", "WBGene00016165", "Q19119", "WBGene00006960", "Q7YTJ8", "WBGene00012425", "A0AAC1", "WBGene00012424", "Q21557", "WBGene00010888", "Q22799", "WBGene00001005", "Q65XS9", "WBGene00043067", "Q22752", "WBGene00012004", "Q20255", "WBGene00022696", "G5ECZ4", "WBGene00001118", "Q18859", "WBGene00016935", "G5EFW7", "WBGene00000906", "P90757", "WBGene00000490", "Q0G838", "WBGene00001122", "G5EDF6", "WBGene00003886", "Q93833", "WBGene00000492", "A0A2C9C2L6", "WBGene00016005", "G5EGF0", "WBGene00000484", "A8DYR7", "WBGene00017973", "G5ED37", "WBGene00003885", "Q9XUC2", "WBGene00012132", "Q17595", "WBGene00001127", "Q6I6D4", "WBGene00001119", "Q95QT8", "WBGene00001129", "Q8I7G4", "WBGene00001117", "Q22830", "WBGene00003883", "Q8TA52", "WBGene00022465", "Q965T6", "WBGene00002230", "G5EEE6", "WBGene00002182", "Q19633", "WBGene00002222", "Q65XS9", "WBGene00043067", "Q7YTJ8", "WBGene00012425", "A0AAC1", "WBGene00012424", "Q21557", "WBGene00010888", "Q22799", "WBGene00001005", "Q22752", "WBGene00012004", "Q18263", "WBGene00016165", "Q19119", "WBGene00006960", "Q19542", "WBGene00000485", "species_29420", "species_29438", "Q19633", "WBGene00002222", "Q965T6", "WBGene00002230", "G5EEE6", "WBGene00002182", "Q17595", "WBGene00001127", "Q93833", "WBGene00000492", "Q6I6D4", "WBGene00001119", "A0A2C9C2L6", "WBGene00016005", "Q95QT8", "WBGene00001129", "G5EGF0", "WBGene00000484", "Q8I7G4", "WBGene00001117", "Q22830", "WBGene00003883", "A8DYR7", "WBGene00017973", "G5ED37", "WBGene00003885", "Q0G838", "WBGene00001122", "Q9XUC2", "WBGene00012132", "G5EDF6", "WBGene00003886", "Q8TA52", "WBGene00022465", "Q20255", "WBGene00022696", "G5EFW7", "WBGene00000906", "G5ECZ4", "WBGene00001118", "Q18859", "WBGene00016935", "P90757", "WBGene00000490" ] }, "reaction_10552842": { "compartment": "compartment_20699", "id": "reaction_10552842", "reactome": "R-CEL-5617828", "name": "TRIP11:IFT20 dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10552840" ], "products": [ "species_10552838", "species_10552833" ], "modifiers": [], "additional_components": [ "Q8TA52", "WBGene00022465", "D0Z5P0", "WBGene00013730", "WBGene00013730", "WBGene00022465" ] }, "reaction_10553695": { "compartment": "compartment_18730", "id": "reaction_10553695", "reactome": "R-CEL-5625416", "name": "Anterograde IFT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10553659" ], "products": [ "species_10553693" ], "modifiers": [], "additional_components": [ "Q65XS9", "WBGene00043067", "Q7YTJ8", "WBGene00012425", "A0AAC1", "WBGene00012424", "Q21557", "WBGene00010888", "Q22799", "WBGene00001005", "Q22752", "WBGene00012004", "Q18263", "WBGene00016165", "Q19119", "WBGene00006960", "Q19542", "WBGene00000485", "Q17595", "WBGene00001127", "Q93833", "WBGene00000492", "Q6I6D4", "WBGene00001119", "A0A2C9C2L6", "WBGene00016005", "Q95QT8", "WBGene00001129", "G5EGF0", "WBGene00000484", "Q8I7G4", "WBGene00001117", "Q22830", "WBGene00003883", "A8DYR7", "WBGene00017973", "G5ED37", "WBGene00003885", "Q0G838", "WBGene00001122", "Q9XUC2", "WBGene00012132", "G5EDF6", "WBGene00003886", "Q8TA52", "WBGene00022465", "species_29420", "species_29438", "Q19633", "WBGene00002222", "Q965T6", "WBGene00002230", "G5EEE6", "WBGene00002182", "Q20255", "WBGene00022696", "G5EFW7", "WBGene00000906", "G5ECZ4", "WBGene00001118", "Q18859", "WBGene00016935", "P90757", "WBGene00000490", "Q20255", "WBGene00022696", "G5ECZ4", "WBGene00001118", "Q18859", "WBGene00016935", "G5EFW7", "WBGene00000906", "P90757", "WBGene00000490", "Q19542", "WBGene00000485", "Q18263", "WBGene00016165", "Q19119", "WBGene00006960", "Q7YTJ8", "WBGene00012425", "A0AAC1", "WBGene00012424", "Q21557", "WBGene00010888", "Q22799", "WBGene00001005", "Q65XS9", "WBGene00043067", "Q22752", "WBGene00012004", "species_29420", "species_29438", "Q965T6", "WBGene00002230", "G5EEE6", "WBGene00002182", "Q19633", "WBGene00002222", "Q0G838", "WBGene00001122", "G5EDF6", "WBGene00003886", "Q93833", "WBGene00000492", "A0A2C9C2L6", "WBGene00016005", "G5EGF0", "WBGene00000484", "A8DYR7", "WBGene00017973", "G5ED37", "WBGene00003885", "Q9XUC2", "WBGene00012132", "Q17595", "WBGene00001127", "Q6I6D4", "WBGene00001119", "Q95QT8", "WBGene00001129", "Q8I7G4", "WBGene00001117", "Q22830", "WBGene00003883", "Q8TA52", "WBGene00022465" ] }, "reaction_10565360": { "compartment": "compartment_7660", "id": "reaction_10565360", "reactome": "R-CEL-8852131", "name": "Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502318", "species_29358", "species_10565305" ], "products": [ "species_10565307", "species_113541" ], "modifiers": [], "additional_components": [ "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "Q27481", "WBGene00006699", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "P49632", "WBGene00006728", "Q27481", "WBGene00006699" ] }, "reaction_10565363": { "compartment": "compartment_70101", "id": "reaction_10565363", "reactome": "R-CEL-8852132", "name": "Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10565228", "species_113592", "species_10502375" ], "products": [ "species_111294", "species_10565258" ], "modifiers": [ [ "species_10565228", "catalyst" ] ], "additional_components": [ "Q27481", "WBGene00006699", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "P49632", "WBGene00006728", "Q27481", "WBGene00006699", "Q27481", "WBGene00006699", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727" ] }, "reaction_10565303": { "compartment": "compartment_70101", "id": "reaction_10565303", "reactome": "R-CEL-8852129", "name": "UBA1 conjugates ubiquitin to cytosolic E2 enzymes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10565258", "species_10565226" ], "products": [ "species_10565260", "species_10565301" ], "modifiers": [], "additional_components": [ "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "P49632", "WBGene00006728", "Q27481", "WBGene00006699", "P35129", "WBGene00002344", "P91853", "WBGene00006732", "Q17720", "WBGene00006717", "Q9U1Q1", "WBGene00006709", "Q95XN7", "WBGene00006702", "Q9TZ69", "WBGene00006715", "Q9N2W9", "WBGene00006705", "H8W3X5", "WBGene00219376", "Q21633", "WBGene00006713", "P34477", "WBGene00006704", "Q93571", "WBGene00006720", "Q27481", "WBGene00006699", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "P49632", "WBGene00006728", "P34477", "WBGene00006704", "Q9U1Q1", "WBGene00006709", "Q9N2W9", "WBGene00006705", "Q9TZ69", "WBGene00006715", "P35129", "WBGene00002344", "P91853", "WBGene00006732", "Q17720", "WBGene00006717", "H8W3X5", "WBGene00219376", "Q21633", "WBGene00006713", "Q95XN7", "WBGene00006702", "Q93571", "WBGene00006720", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727" ] }, "reaction_10565366": { "compartment": "compartment_70101", "id": "reaction_10565366", "reactome": "R-CEL-8852133", "name": "UBA1 conjugates ubiquitin to UBA1 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10565260" ], "products": [ "species_10565228", "species_76577" ], "modifiers": [ [ "species_10565260", "catalyst" ] ], "additional_components": [ "Q27481", "WBGene00006699", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "P49632", "WBGene00006728", "Q27481", "WBGene00006699", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "Q27481", "WBGene00006699", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "P49632", "WBGene00006728" ] }, "reaction_10565369": { "compartment": "compartment_70101", "id": "reaction_10565369", "reactome": "R-CEL-8852134", "name": "UBA1 adenylates ubiquitin in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10502375", "species_10531318" ], "products": [ "species_111294", "species_10565260" ], "modifiers": [ [ "species_10531318", "catalyst" ] ], "additional_components": [ "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "WBGene00006699", "Q27481", "WBGene00006699", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "P49632", "WBGene00006728", "WBGene00006699" ] }, "reaction_10565432": { "compartment": "compartment_70101", "id": "reaction_10565432", "reactome": "R-CEL-8853514", "name": "UCHL3,USP7,USP9X cleaves UBA52 yielding ubiquitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10565425" ], "products": [ "species_10502349", "species_10505892" ], "modifiers": [ [ "species_10565429", "catalyst" ] ], "additional_components": [ "WBGene00006725", "WBGene00006725", "WBGene00006725", "Q7JKC3", "WBGene00010406", "Q9UAV3", "WBGene00006721" ] }, "reaction_10565224": { "compartment": "compartment_7660", "id": "reaction_10565224", "reactome": "R-CEL-8852128", "name": "UBA1 adenylates ubiquitin in the nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502318", "species_29358", "species_10565179" ], "products": [ "species_10565222", "species_113541" ], "modifiers": [], "additional_components": [ "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "WBGene00006699", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "P49632", "WBGene00006728", "Q27481", "WBGene00006699" ] }, "reaction_10565371": { "compartment": "compartment_7660", "id": "reaction_10565371", "reactome": "R-CEL-8852136", "name": "UBA1 conjugates ubiquitin to UBA1 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10565222" ], "products": [ "species_164121", "species_10565305" ], "modifiers": [], "additional_components": [ "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "P49632", "WBGene00006728", "Q27481", "WBGene00006699", "Q27481", "WBGene00006699", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725" ] }, "reaction_10565358": { "compartment": "compartment_7660", "id": "reaction_10565358", "reactome": "R-CEL-8852130", "name": "UBA1 conjugates ubiquitin to nuclear E2 enzymes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10565326", "species_10565307" ], "products": [ "species_10565356", "species_10565222" ], "modifiers": [], "additional_components": [ "H8W3X5", "WBGene00219376", "P35129", "WBGene00002344", "P91853", "WBGene00006732", "Q17720", "WBGene00006717", "Q21633", "WBGene00006713", "Q20872", "WBGene00006731", "Q95XN7", "WBGene00006702", "Q9XWF6", "WBGene00006711", "P52478", "WBGene00006701", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "P49632", "WBGene00006728", "Q27481", "WBGene00006699", "Q95XN7", "WBGene00006702", "H8W3X5", "WBGene00219376", "P52478", "WBGene00006701", "Q21633", "WBGene00006713", "Q20872", "WBGene00006731", "Q9XWF6", "WBGene00006711", "P35129", "WBGene00002344", "P91853", "WBGene00006732", "Q17720", "WBGene00006717", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "P49632", "WBGene00006728", "Q27481", "WBGene00006699" ] }, "reaction_10532323": { "compartment": "compartment_70101", "id": "reaction_10532323", "reactome": "R-CEL-1247645", "name": "RHAG transports CO2 from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113528" ], "products": [ "species_1237009" ], "modifiers": [ [ "species_10524631", "catalyst" ] ], "additional_components": [ "Q17463", "WBGene00004359", "Q22947", "WBGene00004358" ] }, "reaction_10534719": { "compartment": "compartment_70101", "id": "reaction_10534719", "reactome": "R-CEL-1475436", "name": "CA1:Zn2+,CA2:Zn2+ dehydrate HCO3- to CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_111627" ], "products": [ "species_29356", "species_113528" ], "modifiers": [ [ "species_10534714", "catalyst" ] ], "additional_components": [ "O02637", "WBGene00000284", "Q10462", "WBGene00000283", "Q21614", "WBGene00000282", "Q27504", "WBGene00000281", "species_216785" ] }, "reaction_10568241": { "compartment": "compartment_70101", "id": "reaction_10568241", "reactome": "R-CEL-8936849", "name": "AHR:2xHSP90:AIP:PTGES3 binds TCDD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8936852", "species_10568237" ], "products": [ "species_10568239" ], "modifiers": [], "additional_components": [ "Q18688", "WBGene00000915", "O44712", "WBGene00000096", "Q18888", "WBGene00016966", "Q23280", "WBGene00022599", "Q18688", "WBGene00000915", "O44712", "WBGene00000096", "Q18888", "WBGene00016966", "Q23280", "WBGene00022599", "species_8936852" ] }, "reaction_10568289": { "compartment": "compartment_7660", "id": "reaction_10568289", "reactome": "R-CEL-8937191", "name": "AHR:TCDD:2xHSP90AB1:AIP:PTGES3 dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10568281" ], "products": [ "species_10556878", "species_10568287" ], "modifiers": [], "additional_components": [ "Q18688", "WBGene00000915", "Q18888", "WBGene00016966", "Q23280", "WBGene00022599", "O44712", "WBGene00000096", "species_8936852", "species_8936852", "O44712", "WBGene00000096", "Q18688", "WBGene00000915", "Q18888", "WBGene00016966", "Q23280", "WBGene00022599" ] }, "reaction_10568243": { "compartment": "compartment_70101", "id": "reaction_10568243", "reactome": "R-CEL-8936851", "name": "AHRR binds ARNT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10532219", "species_10556884" ], "products": [ "species_10556886" ], "modifiers": [], "additional_components": [ "WBGene00000095", "WBGene00000096", "O44712", "WBGene00000096", "O02219", "WBGene00000095" ] }, "reaction_10568283": { "compartment": "compartment_70101", "id": "reaction_10568283", "reactome": "R-CEL-8937169", "name": "AHR:TCDD:2xHSP90AB1:AIP:PTGES3 translocates from cytosol to nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10568239" ], "products": [ "species_10568281" ], "modifiers": [], "additional_components": [ "Q18688", "WBGene00000915", "O44712", "WBGene00000096", "Q18888", "WBGene00016966", "Q23280", "WBGene00022599", "species_8936852", "Q18688", "WBGene00000915", "Q18888", "WBGene00016966", "Q23280", "WBGene00022599", "O44712", "WBGene00000096", "species_8936852" ] }, "reaction_10568285": { "compartment": "compartment_7660", "id": "reaction_10568285", "reactome": "R-CEL-8937177", "name": "AHR:TCDD binds ARNT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10556878", "species_10532219" ], "products": [ "species_10556882" ], "modifiers": [], "additional_components": [ "species_8936852", "O44712", "WBGene00000096", "WBGene00000095", "O02219", "WBGene00000095", "species_8936852", "O44712", "WBGene00000096" ] }, "reaction_10569050": { "compartment": "compartment_7660", "id": "reaction_10569050", "reactome": "R-CEL-8951676", "name": "RUNX3 binds TEADs and YAP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10566205", "species_10542185" ], "products": [ "species_10569048" ], "modifiers": [], "additional_components": [ "WBGene00004393", "Q19849", "WBGene00001208", "Q19404", "WBGene00008748", "Q19849", "WBGene00001208", "Q19404", "WBGene00008748", "G5EFQ5", "WBGene00004393" ] }, "reaction_10569036": { "compartment": "compartment_7660", "id": "reaction_10569036", "reactome": "R-CEL-8951428", "name": "RUNX3 binds CTNNB1:TCF7L2,(LEF1,TCF7L1,TCF7)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10566205", "species_10547172" ], "products": [ "species_10569034" ], "modifiers": [], "additional_components": [ "WBGene00004393", "Q10666", "WBGene00004077", "O44326", "WBGene00001979", "Q10666", "WBGene00004077", "O44326", "WBGene00001979", "G5EFQ5", "WBGene00004393" ] }, "reaction_10527860": { "compartment": "compartment_20699", "id": "reaction_10527860", "reactome": "R-CEL-741450", "name": "SLC35A3 exchanges UDP-GlcNAc for UMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_735698", "species_162756" ], "products": [ "species_914003", "species_109402" ], "modifiers": [ [ "species_10527857", "catalyst" ] ], "additional_components": [ "WBGene00015404" ] }, "reaction_10527876": { "compartment": "compartment_20699", "id": "reaction_10527876", "reactome": "R-CEL-742354", "name": "SLC35B4 mediates the transport of UDP-N-acetylglucosamine into the Golgi lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_162756" ], "products": [ "species_914003" ], "modifiers": [ [ "species_10527873", "catalyst" ] ], "additional_components": [ "WBGene00017480" ] }, "reaction_10527879": { "compartment": "compartment_20699", "id": "reaction_10527879", "reactome": "R-CEL-742373", "name": "SLC35B4 mediates the transport of UDP-xylose into the Golgi lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_742353" ], "products": [ "species_742361" ], "modifiers": [ [ "species_10527873", "catalyst" ] ], "additional_components": [ "WBGene00017480" ] }, "reaction_10527832": { "compartment": "compartment_20699", "id": "reaction_10527832", "reactome": "R-CEL-727807", "name": "SLC35A1 exchanges CMP-Neu5Ac for CMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_727810", "species_4085435" ], "products": [ "species_727815", "species_109395" ], "modifiers": [ [ "species_10527829", "catalyst" ] ], "additional_components": [ "Q93890", "WBGene00005153", "O01879", "WBGene00022577", "O02345", "WBGene00014139", "Q02334", "WBGene00022721" ] }, "reaction_10527868": { "compartment": "compartment_20699", "id": "reaction_10527868", "reactome": "R-CEL-742345", "name": "SLC35C1 transport UDP-Fuc from cytosol to Golgi lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_742368" ], "products": [ "species_205683" ], "modifiers": [ [ "species_10527865", "catalyst" ] ], "additional_components": [ "WBGene00008237" ] }, "reaction_10527884": { "compartment": "compartment_20699", "id": "reaction_10527884", "reactome": "R-CEL-744230", "name": "SLC35D2 mediates the antiport of GDP-mannose in exchange for GMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_162860", "species_744239" ], "products": [ "species_113578", "species_744233" ], "modifiers": [ [ "species_10527881", "catalyst" ] ], "additional_components": [ "WBGene00005025" ] }, "reaction_10527837": { "compartment": "compartment_20699", "id": "reaction_10527837", "reactome": "R-CEL-735702", "name": "SLC35A2 exchanges UDP-Gal, UDP-GalNAc for UMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_735698", "species_735692" ], "products": [ "species_109402", "species_735691" ], "modifiers": [ [ "species_10527834", "catalyst" ] ], "additional_components": [ "species_735700", "species_1981137", "species_1981137", "species_735700", "WBGene00005153" ] }, "reaction_10527886": { "compartment": "compartment_20699", "id": "reaction_10527886", "reactome": "R-CEL-744231", "name": "SLC35D2 exchanges UDP-sugars for UMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_744229", "species_735698" ], "products": [ "species_109402", "species_744234" ], "modifiers": [ [ "species_10527881", "catalyst" ] ], "additional_components": [ "species_173594", "species_914003", "species_173594", "species_914003", "WBGene00005025" ] }, "reaction_10508358": { "compartment": "compartment_7660", "id": "reaction_10508358", "reactome": "R-CEL-77613", "name": "Binding of ADAR2 homodimer to dsRNA duplex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_75086", "species_10508354" ], "products": [ "species_10508356" ], "modifiers": [], "additional_components": [ "Q22618", "WBGene00000080", "Q22618", "WBGene00000080" ] }, "reaction_10508826": { "compartment": "compartment_7660", "id": "reaction_10508826", "reactome": "R-CEL-111237", "name": "Formation of ADAR1 homodimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10507129" ], "products": [ "species_10507131" ], "modifiers": [], "additional_components": [ "Q93412", "WBGene00008397", "Q9U3D6", "WBGene00000079", "Q93412", "WBGene00008397", "Q9U3D6", "WBGene00000079" ] }, "reaction_10508828": { "compartment": "compartment_7660", "id": "reaction_10508828", "reactome": "R-CEL-111238", "name": "Formation of ADAR2 homodimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508352" ], "products": [ "species_10508354" ], "modifiers": [], "additional_components": [ "WBGene00000080", "Q22618", "WBGene00000080" ] }, "reaction_10507135": { "compartment": "compartment_7660", "id": "reaction_10507135", "reactome": "R-CEL-75090", "name": "Binding of ADAR1 homodimer to dsRNA duplex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_75086", "species_10507131" ], "products": [ "species_10507133" ], "modifiers": [], "additional_components": [ "Q93412", "WBGene00008397", "Q9U3D6", "WBGene00000079", "Q93412", "WBGene00008397", "Q9U3D6", "WBGene00000079" ] }, "reaction_10508368": { "compartment": "compartment_7660", "id": "reaction_10508368", "reactome": "R-CEL-77615", "name": "Deamination at C6 position of adenosine in Editosome (ADAR2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10508356" ], "products": [ "species_10508365", "species_76230" ], "modifiers": [ [ "species_10508354", "catalyst" ] ], "additional_components": [ "Q22618", "WBGene00000080", "Q22618", "WBGene00000080", "Q22618", "WBGene00000080" ] }, "reaction_10508363": { "compartment": "compartment_7660", "id": "reaction_10508363", "reactome": "R-CEL-77614", "name": "Deamination at C6 position of adenosine in Editosome (ADAR1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10507133" ], "products": [ "species_10508360", "species_76230" ], "modifiers": [ [ "species_10507131", "catalyst" ] ], "additional_components": [ "Q93412", "WBGene00008397", "Q9U3D6", "WBGene00000079", "Q93412", "WBGene00008397", "Q9U3D6", "WBGene00000079", "Q93412", "WBGene00008397", "Q9U3D6", "WBGene00000079" ] }, "reaction_10508608": { "compartment": "compartment_70101", "id": "reaction_10508608", "reactome": "R-CEL-109864", "name": "Dissociation of p-T,Y-MAPK1:p-S,T-MAP2K2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508601" ], "products": [ "species_10508573", "species_10508599" ], "modifiers": [], "additional_components": [ "P39745", "WBGene00003401", "Q10664", "WBGene00003186", "WBGene00003186", "WBGene00003401" ] }, "reaction_10508579": { "compartment": "compartment_70101", "id": "reaction_10508579", "reactome": "R-CEL-109858", "name": "MAP2K2 binds MAPK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508575", "species_10508573" ], "products": [ "species_10508577" ], "modifiers": [], "additional_components": [ "WBGene00003401", "WBGene00003186", "Q10664", "WBGene00003186", "P39745", "WBGene00003401" ] }, "reaction_10508604": { "compartment": "compartment_70101", "id": "reaction_10508604", "reactome": "R-CEL-109862", "name": "MAP2K2 phosphorylates MAPK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10508577" ], "products": [ "species_29370", "species_10508601" ], "modifiers": [ [ "species_10508577", "catalyst" ] ], "additional_components": [ "Q10664", "WBGene00003186", "P39745", "WBGene00003401", "P39745", "WBGene00003401", "Q10664", "WBGene00003186", "Q10664", "WBGene00003186", "P39745", "WBGene00003401" ] }, "reaction_10525426": { "compartment": "compartment_5460", "id": "reaction_10525426", "reactome": "R-CEL-449937", "name": "pyrophosphate + H2O => 2 orthophosphate [mitochondrial]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_159450", "species_113521" ], "products": [ "species_113548" ], "modifiers": [ [ "species_10525423", "catalyst" ], [ "species_109496", "catalyst" ] ], "additional_components": [ "Q18680", "WBGene00008149" ] }, "reaction_10504277": { "compartment": "compartment_70101", "id": "reaction_10504277", "reactome": "R-CEL-71732", "name": "pyrophosphate + H2O => 2 orthophosphate [cytosolic]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111294", "species_29356" ], "products": [ "species_29372" ], "modifiers": [ [ "species_10504274", "catalyst" ], [ "species_29926", "catalyst" ] ], "additional_components": [ "Q18680", "WBGene00008149" ] }, "reaction_10571313": { "compartment": "compartment_876", "id": "reaction_10571313", "reactome": "R-CEL-9017491", "name": "RHOJ GEFs activate RHOJ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10571305" ], "products": [ "species_29420", "species_10571303" ], "modifiers": [ [ "species_10531723", "catalyst" ] ], "additional_components": [ "O62422", "WBGene00012532", "Q05062", "WBGene00000390", "species_29420", "O62422", "WBGene00012532", "Q05062", "WBGene00000390", "species_29438", "WBGene00018520" ] }, "reaction_10571310": { "compartment": "compartment_876", "id": "reaction_10571310", "reactome": "R-CEL-9017488", "name": "RHOJ GAPs stimulate RHOJ GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10571303" ], "products": [ "species_29372", "species_10571305" ], "modifiers": [ [ "species_10571307", "catalyst" ] ], "additional_components": [ "O62422", "WBGene00012532", "Q05062", "WBGene00000390", "species_29438", "O62422", "WBGene00012532", "Q05062", "WBGene00000390", "species_29420", "O45611", "WBGene00010374", "H2KZV6", "WBGene00020209", "Q23130", "WBGene00012203" ] }, "reaction_10571008": { "compartment": "compartment_876", "id": "reaction_10571008", "reactome": "R-CEL-9013009", "name": "RHOA binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10571004", "species_10509488" ], "products": [ "species_10571006" ], "modifiers": [], "additional_components": [ "Q7JP75", "WBGene00000872", "Q19479", "WBGene00008848", "A0A4V0IKG6", "WBGene00007287", "G5EDU3", "WBGene00004040", "P92199", "WBGene00002694", "A0A4V0ILM7", "WBGene00009793", "D6VPA1", "WBGene00018976", "Q21025", "WBGene00019087", "Q9XVH4", "WBGene00019087", "Q17777", "WBGene00007409", "Q09994", "WBGene00019608", "O17772", "WBGene00003980", "Q22038", "WBGene00004357", "species_29438", "Q22038", "WBGene00004357", "species_29438", "Q7JP75", "WBGene00000872", "Q19479", "WBGene00008848", "A0A4V0IKG6", "WBGene00007287", "G5EDU3", "WBGene00004040", "P92199", "WBGene00002694", "A0A4V0ILM7", "WBGene00009793", "D6VPA1", "WBGene00018976", "Q21025", "WBGene00019087", "Q9XVH4", "WBGene00019087", "Q17777", "WBGene00007409", "Q09994", "WBGene00019608", "O17772", "WBGene00003980" ] }, "reaction_10570947": { "compartment": "compartment_70101", "id": "reaction_10570947", "reactome": "R-CEL-9012835", "name": "GDIs block activation of RHOA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509486", "species_10570939" ], "products": [ "species_10570945" ], "modifiers": [], "additional_components": [ "Q22038", "WBGene00004357", "species_29420", "WBGene00004356", "Q20496", "WBGene00004356", "Q22038", "WBGene00004357", "species_29420" ] }, "reaction_10570274": { "compartment": "compartment_70101", "id": "reaction_10570274", "reactome": "R-CEL-8980691", "name": "RHOA GEFs activate RHOA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10509486" ], "products": [ "species_29420", "species_10509488" ], "modifiers": [ [ "species_10570271", "catalyst" ] ], "additional_components": [ "Q22038", "WBGene00004357", "species_29420", "Q22038", "WBGene00004357", "species_29438", "G5EFE1", "WBGene00006468", "H2L0P5", "WBGene00022391", "O61528", "WBGene00006805", "A0A0K3AQN0", "WBGene00013682", "Q9U3P2", "WBGene00007750", "Q965J0", "WBGene00019487", "S6EZU2", "WBGene00006476", "Q45FX5", "WBGene00006887", "Q21653", "WBGene00019832", "H2KYI7", "WBGene00006496", "Q9U364", "WBGene00002297" ] }, "reaction_10570420": { "compartment": "compartment_70101", "id": "reaction_10570420", "reactome": "R-CEL-8981637", "name": "RHOA GAPs stimulate RHOA GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10509488" ], "products": [ "species_10509486", "species_29372" ], "modifiers": [ [ "species_10570417", "catalyst" ] ], "additional_components": [ "Q22038", "WBGene00004357", "species_29438", "Q22038", "WBGene00004357", "species_29420", "H2KZV6", "WBGene00020209", "O45611", "WBGene00010374", "Q20498", "WBGene00009800", "O01443", "WBGene00015303", "A0A0K3AW57", "Y75B7AL.4c", "U4PAK0", "WBGene00007064", "Q9XW53", "WBGene00013135", "Q20440", "WBGene00001559", "Q23130", "WBGene00012203", "G5EF80", "WBGene00014051" ] }, "reaction_10570951": { "compartment": "compartment_876", "id": "reaction_10570951", "reactome": "R-CEL-9013006", "name": "RHOA:GTP translocates to the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509488" ], "products": [ "species_10570949" ], "modifiers": [], "additional_components": [ "Q22038", "WBGene00004357", "species_29438", "Q22038", "WBGene00004357", "species_29438" ] }, "reaction_10571347": { "compartment": "compartment_876", "id": "reaction_10571347", "reactome": "R-CEL-9018747", "name": "RHOQ GEFs activate RHOQ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10571331" ], "products": [ "species_29420", "species_10553913" ], "modifiers": [ [ "species_10571344", "catalyst" ] ], "additional_components": [ "O62422", "WBGene00012532", "Q05062", "WBGene00000390", "species_29420", "O62422", "WBGene00012532", "Q05062", "WBGene00000390", "species_29438", "Q9U3P2", "WBGene00007750", "A0A0K3AS36", "Y116A8C.36d" ] }, "reaction_10571336": { "compartment": "compartment_70101", "id": "reaction_10571336", "reactome": "R-CEL-9018745", "name": "RHOQ GAPs stimulate RHOQ GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10553913" ], "products": [ "species_29372", "species_10571331" ], "modifiers": [ [ "species_10571333", "catalyst" ] ], "additional_components": [ "O62422", "WBGene00012532", "Q05062", "WBGene00000390", "species_29438", "O62422", "WBGene00012532", "Q05062", "WBGene00000390", "species_29420", "Q20440", "WBGene00001559", "H2KZV6", "WBGene00020209", "Q23130", "WBGene00012203" ] }, "reaction_10553928": { "compartment": "compartment_13949", "id": "reaction_10553928", "reactome": "R-CEL-5627072", "name": "RHOQ binds GOPC:CFTR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10553903", "species_10553892" ], "products": [ "species_10553905" ], "modifiers": [], "additional_components": [ "O62422", "WBGene00012532", "Q05062", "WBGene00000390", "species_29438", "Q19625", "WBGene00003412", "Q95QV2", "WBGene00000477", "O18302", "WBGene00014101", "Q19625", "WBGene00003412", "Q95QV2", "WBGene00000477", "O18302", "WBGene00014101", "O62422", "WBGene00012532", "Q05062", "WBGene00000390", "species_29438" ] }, "reaction_10571342": { "compartment": "compartment_70101", "id": "reaction_10571342", "reactome": "R-CEL-9018746", "name": "RHOQ binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10571338", "species_10553913" ], "products": [ "species_10571340" ], "modifiers": [], "additional_components": [ "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "Q20498", "WBGene00009800", "Q19253", "WBGene00017298", "Q9XUS7", "WBGene00010663", "O17772", "WBGene00003980", "O62422", "WBGene00012532", "Q05062", "WBGene00000390", "species_29438", "O62422", "WBGene00012532", "Q05062", "WBGene00000390", "species_29438", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "Q20498", "WBGene00009800", "Q19253", "WBGene00017298", "Q9XUS7", "WBGene00010663", "O17772", "WBGene00003980" ] }, "reaction_10571470": { "compartment": "compartment_876", "id": "reaction_10571470", "reactome": "R-CEL-9018836", "name": "RHOQ translocates to the Golgi-associated vesicle membranes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10553913" ], "products": [ "species_10553903" ], "modifiers": [], "additional_components": [ "O62422", "WBGene00012532", "Q05062", "WBGene00000390", "species_29438", "O62422", "WBGene00012532", "Q05062", "WBGene00000390", "species_29438" ] }, "reaction_10571361": { "compartment": "compartment_876", "id": "reaction_10571361", "reactome": "R-CEL-9018754", "name": "GDIs bind RHOH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10571357", "species_10570939" ], "products": [ "species_10571359" ], "modifiers": [], "additional_components": [ "Q03206", "ced-10", "Q94124", "WBGene00004287", "Q9BL44", "WBGene00022177", "species_29438", "WBGene00004356", "Q20496", "WBGene00004356", "Q03206", "ced-10", "Q94124", "WBGene00004287", "Q9BL44", "WBGene00022177", "species_29438" ] }, "reaction_10571393": { "compartment": "compartment_876", "id": "reaction_10571393", "reactome": "R-CEL-9018758", "name": "RHOH binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10571389", "species_10571357" ], "products": [ "species_10571391" ], "modifiers": [], "additional_components": [ "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "G5EFU0", "WBGene00006443", "Q18462", "WBGene00016416", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "G5ECJ6", "WBGene00000812", "Q03206", "ced-10", "Q94124", "WBGene00004287", "Q9BL44", "WBGene00022177", "species_29438", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "G5EFU0", "WBGene00006443", "Q18462", "WBGene00016416", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "G5ECJ6", "WBGene00000812", "Q03206", "ced-10", "Q94124", "WBGene00004287", "Q9BL44", "WBGene00022177", "species_29438" ] }, "reaction_10571363": { "compartment": "compartment_876", "id": "reaction_10571363", "reactome": "R-CEL-9018756", "name": "RHOH binds GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10571355" ], "products": [ "species_10571357" ], "modifiers": [], "additional_components": [ "Q03206", "ced-10", "Q94124", "WBGene00004287", "Q9BL44", "WBGene00022177", "Q03206", "ced-10", "Q94124", "WBGene00004287", "Q9BL44", "WBGene00022177", "species_29438" ] }, "reaction_10571418": { "compartment": "compartment_876", "id": "reaction_10571418", "reactome": "R-CEL-9018766", "name": "RHOU binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10571400", "species_10571414" ], "products": [ "species_10571416" ], "modifiers": [], "additional_components": [ "Q19739", "WBGene00009059", "species_29438", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "G5EFU0", "WBGene00006443", "Q20498", "WBGene00009800", "Q95PX0", "WBGene00006410", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "G5EFU0", "WBGene00006443", "Q20498", "WBGene00009800", "Q95PX0", "WBGene00006410", "Q19739", "WBGene00009059", "species_29438" ] }, "reaction_10571423": { "compartment": "compartment_876", "id": "reaction_10571423", "reactome": "R-CEL-9018768", "name": "RHOU auto-activates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10571420" ], "products": [ "species_29420", "species_10571400" ], "modifiers": [ [ "species_10571420", "catalyst" ] ], "additional_components": [ "Q19739", "WBGene00009059", "species_29420", "Q19739", "WBGene00009059", "species_29438", "Q19739", "WBGene00009059", "species_29420" ] }, "reaction_10571105": { "compartment": "compartment_876", "id": "reaction_10571105", "reactome": "R-CEL-9013147", "name": "RAC1 GDIs block activation of RAC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10570939", "species_10541992" ], "products": [ "species_10571103" ], "modifiers": [], "additional_components": [ "WBGene00004356", "species_29420", "Q03206", "ced-10", "Q20496", "WBGene00004356", "species_29420", "Q03206", "ced-10" ] }, "reaction_10573125": { "compartment": "compartment_876", "id": "reaction_10573125", "reactome": "R-CEL-9691168", "name": "RAC1 translocates to the endoplasmic reticulum membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509457" ], "products": [ "species_10573123" ], "modifiers": [], "additional_components": [ "species_29438", "Q03206", "ced-10", "Q03206", "ced-10", "species_29438" ] }, "reaction_10571067": { "compartment": "compartment_876", "id": "reaction_10571067", "reactome": "R-CEL-9013144", "name": "RAC1 GAPs stimulate RAC1 GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10509457" ], "products": [ "species_29372", "species_10541992" ], "modifiers": [ [ "species_10571064", "catalyst" ] ], "additional_components": [ "species_29438", "Q03206", "ced-10", "species_29420", "Q03206", "ced-10", "P34288", "WBGene00015418", "Q9XVI0", "WBGene00011970", "P46941", "WBGene00008006", "Q20498", "WBGene00009800", "U4PAK0", "WBGene00007064", "Q9XW53", "WBGene00013135", "A0A2K5AU23", "WBGene00021324", "G5EF80", "WBGene00014051", "Q965N4", "WBGene00015267", "Q86NH1", "WBGene00006363", "Q19370", "WBGene00006406" ] }, "reaction_10571101": { "compartment": "compartment_876", "id": "reaction_10571101", "reactome": "R-CEL-9013145", "name": "RAC1 binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10571097", "species_10509457" ], "products": [ "species_10571099" ], "modifiers": [], "additional_components": [ "O44518", "WBGene00001579", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "O01583", "WBGene00006437", "G5EFU0", "WBGene00006443", "G5EDU3", "WBGene00004040", "A0A4V0ILM7", "WBGene00009793", "G5EDP9", "WBGene00000001", "Q94125", "WBGene00000090", "Q18879", "WBGene00000302", "Q94051", "WBGene00000301", "O17772", "WBGene00003980", "Q9BL72", "WBGene00021698", "Q17865", "WBGene00007486", "Q9NAN2", "WBGene00003921", "A5Z2X2", "WBGene00303007", "P55163", "WBGene00001580", "Q9XVK6", "WBGene00006958", "Q10929", "WBGene00015146", "species_29438", "Q03206", "ced-10", "species_29438", "Q03206", "ced-10", "O44518", "WBGene00001579", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "O01583", "WBGene00006437", "G5EFU0", "WBGene00006443", "G5EDU3", "WBGene00004040", "A0A4V0ILM7", "WBGene00009793", "G5EDP9", "WBGene00000001", "Q94125", "WBGene00000090", "Q18879", "WBGene00000302", "Q94051", "WBGene00000301", "O17772", "WBGene00003980", "Q9BL72", "WBGene00021698", "Q17865", "WBGene00007486", "Q9NAN2", "WBGene00003921", "A5Z2X2", "WBGene00303007", "P55163", "WBGene00001580", "Q9XVK6", "WBGene00006958", "Q10929", "WBGene00015146" ] }, "reaction_10571020": { "compartment": "compartment_876", "id": "reaction_10571020", "reactome": "R-CEL-9013143", "name": "RAC1 GEFs activate RAC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10541992" ], "products": [ "species_29420", "species_10509457" ], "modifiers": [ [ "species_10571017", "catalyst" ] ], "additional_components": [ "species_29420", "Q03206", "ced-10", "species_29438", "Q03206", "ced-10", "X5LX76", "WBGene00006450", "Q19572", "WBGene00001674", "O01847", "WBGene00015704", "Q45FX5", "WBGene00006887" ] }, "reaction_10571433": { "compartment": "compartment_876", "id": "reaction_10571433", "reactome": "R-CEL-9018794", "name": "RHOV binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10571429", "species_10571427" ], "products": [ "species_10571431" ], "modifiers": [], "additional_components": [ "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "G5EFU0", "WBGene00006443", "Q19739", "WBGene00009059", "species_29438", "Q19739", "WBGene00009059", "species_29438", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "G5EFU0", "WBGene00006443" ] }, "reaction_10571437": { "compartment": "compartment_876", "id": "reaction_10571437", "reactome": "R-CEL-9018798", "name": "RHOV binds GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10571435" ], "products": [ "species_29420", "species_10571427" ], "modifiers": [], "additional_components": [ "Q19739", "WBGene00009059", "species_29420", "Q19739", "WBGene00009059", "species_29438" ] }, "reaction_10571156": { "compartment": "compartment_876", "id": "reaction_10571156", "reactome": "R-CEL-9013161", "name": "CDC42 GAPs stimulate CDC42 GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10512279" ], "products": [ "species_10571134", "species_29372" ], "modifiers": [ [ "species_10571153", "catalyst" ] ], "additional_components": [ "Q05062", "WBGene00000390", "species_29438", "Q05062", "WBGene00000390", "species_29420", "Q9XW53", "WBGene00013135", "G5EF80", "WBGene00014051", "H2KZV4", "WBGene00017760", "Q23130", "WBGene00012203" ] }, "reaction_10571142": { "compartment": "compartment_876", "id": "reaction_10571142", "reactome": "R-CEL-9013158", "name": "CDC42 GDIs block activation of CDC42", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10571134", "species_10571138" ], "products": [ "species_10571140" ], "modifiers": [], "additional_components": [ "Q05062", "WBGene00000390", "species_29420", "Q20496", "WBGene00004356", "Q18879", "WBGene00000302", "Q94051", "WBGene00000301", "Q20496", "WBGene00004356", "Q18879", "WBGene00000302", "Q94051", "WBGene00000301", "Q05062", "WBGene00000390", "species_29420" ] }, "reaction_10573129": { "compartment": "compartment_876", "id": "reaction_10573129", "reactome": "R-CEL-9692800", "name": "CDC42 translocates to the endoplasmic reticulum membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10512279" ], "products": [ "species_10573127" ], "modifiers": [], "additional_components": [ "Q05062", "WBGene00000390", "species_29438", "Q05062", "WBGene00000390", "species_29438" ] }, "reaction_10571149": { "compartment": "compartment_876", "id": "reaction_10571149", "reactome": "R-CEL-9013159", "name": "CDC42 GEFs activate CDC42", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10571134", "species_29438" ], "products": [ "species_29420", "species_10512279" ], "modifiers": [ [ "species_10571146", "catalyst" ] ], "additional_components": [ "Q05062", "WBGene00000390", "species_29420", "Q05062", "WBGene00000390", "species_29438", "Q19572", "WBGene00001674", "X5LV34", "WBGene00001366", "G5EF62", "WBGene00009337", "Q965J0", "WBGene00019487", "H2KYI7", "WBGene00006496", "G5ECK4", "WBGene00044989" ] }, "reaction_10571217": { "compartment": "compartment_876", "id": "reaction_10571217", "reactome": "R-CEL-9013452", "name": "RHOD:GTP translocates to the endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10571194" ], "products": [ "species_10554702" ], "modifiers": [], "additional_components": [ "Q22038", "WBGene00004357", "species_29438", "Q22038", "WBGene00004357", "species_29438" ] }, "reaction_10573201": { "compartment": "compartment_876", "id": "reaction_10573201", "reactome": "R-CEL-9693243", "name": "RHOD translocates to the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10571194" ], "products": [ "species_10573199" ], "modifiers": [], "additional_components": [ "Q22038", "WBGene00004357", "species_29438", "Q22038", "WBGene00004357", "species_29438" ] }, "reaction_10573187": { "compartment": "compartment_876", "id": "reaction_10573187", "reactome": "R-CEL-9693207", "name": "RHOD translocates to the mitochondrial outer membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10571194" ], "products": [ "species_10573185" ], "modifiers": [], "additional_components": [ "Q22038", "WBGene00004357", "species_29438", "Q22038", "WBGene00004357", "species_29438" ] }, "reaction_10571202": { "compartment": "compartment_876", "id": "reaction_10571202", "reactome": "R-CEL-9013437", "name": "RHOD GAPs stimulate RHOD GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10571194" ], "products": [ "species_29372", "species_10571190" ], "modifiers": [ [ "species_10571199", "catalyst" ] ], "additional_components": [ "Q22038", "WBGene00004357", "species_29438", "Q22038", "WBGene00004357", "species_29420", "Q20498", "WBGene00009800", "O45611", "WBGene00010374", "H2KZV6", "WBGene00020209", "Q23130", "WBGene00012203" ] }, "reaction_10573195": { "compartment": "compartment_17906", "id": "reaction_10573195", "reactome": "R-CEL-9693214", "name": "RHOD binds effectors at the mitochondrial outer membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10573191", "species_10573185" ], "products": [ "species_10573193" ], "modifiers": [], "additional_components": [ "G5EFU0", "WBGene00006443", "Q22038", "WBGene00004357", "species_29438", "Q22038", "WBGene00004357", "species_29438", "G5EFU0", "WBGene00006443" ] }, "reaction_10571197": { "compartment": "compartment_876", "id": "reaction_10571197", "reactome": "R-CEL-9013435", "name": "RHOD auto-activates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10571190" ], "products": [ "species_29420", "species_10571194" ], "modifiers": [ [ "species_10571190", "catalyst" ] ], "additional_components": [ "Q22038", "WBGene00004357", "species_29420", "Q22038", "WBGene00004357", "species_29438", "Q22038", "WBGene00004357", "species_29420" ] }, "reaction_10573181": { "compartment": "compartment_70101", "id": "reaction_10573181", "reactome": "R-CEL-9693198", "name": "RHOD binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10571194", "species_10573177" ], "products": [ "species_10573179" ], "modifiers": [], "additional_components": [ "Q22038", "WBGene00004357", "species_29438", "Q23158", "WBGene00000228", "Q9XUT0", "WBGene00010664", "Q23130", "WBGene00012203", "Q18879", "WBGene00000302", "Q94051", "WBGene00000301", "Q23146", "WBGene00004271", "O02163", "WBGene00020376", "Q7K7J0", "WBGene00001575", "Q9XUB9", "WBGene00012128", "Q20952", "WBGene00000073", "Q9U9K0", "WBGene00000072", "Q7JP75", "WBGene00000872", "Q19479", "WBGene00008848", "Q9U2A6", "WBGene00012980", "B3WFV9", "WBGene00009920", "Q58QG8", "WBGene00019844", "O02495", "WBGene00004897", "H2KY90", "WBGene00015171", "A0A679L8R0", "WBGene00020443", "P34686", "WBGene00000293", "Q21443", "WBGene00003052", "Q23158", "WBGene00000228", "Q9XUT0", "WBGene00010664", "Q23130", "WBGene00012203", "Q18879", "WBGene00000302", "Q94051", "WBGene00000301", "Q23146", "WBGene00004271", "O02163", "WBGene00020376", "Q7K7J0", "WBGene00001575", "Q9XUB9", "WBGene00012128", "Q20952", "WBGene00000073", "Q9U9K0", "WBGene00000072", "Q7JP75", "WBGene00000872", "Q19479", "WBGene00008848", "Q9U2A6", "WBGene00012980", "B3WFV9", "WBGene00009920", "Q58QG8", "WBGene00019844", "O02495", "WBGene00004897", "H2KY90", "WBGene00015171", "A0A679L8R0", "WBGene00020443", "P34686", "WBGene00000293", "Q21443", "WBGene00003052", "Q22038", "WBGene00004357", "species_29438" ] }, "reaction_10571215": { "compartment": "compartment_876", "id": "reaction_10571215", "reactome": "R-CEL-9013438", "name": "RHOD binds effectors at the endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10554702", "species_10571211" ], "products": [ "species_10571213" ], "modifiers": [], "additional_components": [ "Q22038", "WBGene00004357", "species_29438", "Q7JP75", "WBGene00000872", "Q7JP75", "WBGene00000872", "Q22038", "WBGene00004357", "species_29438" ] }, "reaction_10571267": { "compartment": "compartment_70101", "id": "reaction_10571267", "reactome": "R-CEL-9014296", "name": "RAC2 GEFs activate RAC2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10571245" ], "products": [ "species_10509471", "species_29420" ], "modifiers": [ [ "species_10571264", "catalyst" ] ], "additional_components": [ "species_29420", "Q94124", "WBGene00004287", "Q9BL44", "WBGene00022177", "Q03206", "ced-10", "Q94124", "WBGene00004287", "Q9BL44", "WBGene00022177", "Q03206", "ced-10", "species_29438", "O01847", "WBGene00015704", "H2KYI7", "WBGene00006496", "Q45FX5", "WBGene00006887", "G5EEN3", "WBGene00000419" ] }, "reaction_10571251": { "compartment": "compartment_70101", "id": "reaction_10571251", "reactome": "R-CEL-9014293", "name": "RAC2 GDIs block activation of RAC2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10571245", "species_10570939" ], "products": [ "species_10571249" ], "modifiers": [], "additional_components": [ "species_29420", "Q94124", "WBGene00004287", "Q9BL44", "WBGene00022177", "Q03206", "ced-10", "WBGene00004356", "Q20496", "WBGene00004356", "Q94124", "WBGene00004287", "Q9BL44", "WBGene00022177", "Q03206", "ced-10", "species_29420" ] }, "reaction_10571269": { "compartment": "compartment_876", "id": "reaction_10571269", "reactome": "R-CEL-9014420", "name": "RAC2 translocates to the phagocytic vesicle membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509471" ], "products": [ "species_10554742" ], "modifiers": [], "additional_components": [ "Q94124", "WBGene00004287", "Q9BL44", "WBGene00022177", "Q03206", "ced-10", "species_29438", "Q94124", "WBGene00004287", "Q9BL44", "WBGene00022177", "Q03206", "ced-10", "species_29438" ] }, "reaction_10573381": { "compartment": "compartment_876", "id": "reaction_10573381", "reactome": "R-CEL-9714483", "name": "RAC2 translocates to the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509471" ], "products": [ "species_10573379" ], "modifiers": [], "additional_components": [ "Q94124", "WBGene00004287", "Q9BL44", "WBGene00022177", "Q03206", "ced-10", "species_29438", "Q03206", "ced-10", "Q94124", "WBGene00004287", "Q9BL44", "WBGene00022177", "species_29438" ] }, "reaction_10571257": { "compartment": "compartment_70101", "id": "reaction_10571257", "reactome": "R-CEL-9014294", "name": "RAC2 binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509471", "species_10571253" ], "products": [ "species_10571255" ], "modifiers": [], "additional_components": [ "Q94124", "WBGene00004287", "Q9BL44", "WBGene00022177", "Q03206", "ced-10", "species_29438", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "G5EFU0", "WBGene00006443", "G5EDU3", "WBGene00004040", "G5EDP9", "WBGene00000001", "Q94125", "WBGene00000090", "O17772", "WBGene00003980", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "G5EFU0", "WBGene00006443", "G5EDU3", "WBGene00004040", "G5EDP9", "WBGene00000001", "Q94125", "WBGene00000090", "O17772", "WBGene00003980", "Q94124", "WBGene00004287", "Q9BL44", "WBGene00022177", "Q03206", "ced-10", "species_29438" ] }, "reaction_10573369": { "compartment": "compartment_17906", "id": "reaction_10573369", "reactome": "R-CEL-9714477", "name": "RAC2 binds effectors at the mitochondrial outer membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10573348", "species_10573365" ], "products": [ "species_10573367" ], "modifiers": [], "additional_components": [ "Q9BL44", "WBGene00022177", "Q03206", "ced-10", "Q94124", "WBGene00004287", "species_29438", "Q9BL44", "WBGene00022177", "Q03206", "ced-10", "Q94124", "WBGene00004287", "species_29438" ] }, "reaction_10573371": { "compartment": "compartment_876", "id": "reaction_10573371", "reactome": "R-CEL-9714480", "name": "RAC2 translocates to the mitochondrial membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509471" ], "products": [ "species_10573348" ], "modifiers": [], "additional_components": [ "Q94124", "WBGene00004287", "Q9BL44", "WBGene00022177", "Q03206", "ced-10", "species_29438", "Q9BL44", "WBGene00022177", "Q03206", "ced-10", "Q94124", "WBGene00004287", "species_29438" ] }, "reaction_10571262": { "compartment": "compartment_70101", "id": "reaction_10571262", "reactome": "R-CEL-9014295", "name": "RAC2 GAPs stimulate RAC2 GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509471", "species_29356" ], "products": [ "species_29372", "species_10571245" ], "modifiers": [ [ "species_10571259", "catalyst" ] ], "additional_components": [ "Q94124", "WBGene00004287", "Q9BL44", "WBGene00022177", "Q03206", "ced-10", "species_29438", "species_29420", "Q94124", "WBGene00004287", "Q9BL44", "WBGene00022177", "Q03206", "ced-10", "O45611", "WBGene00010374", "H2KZV6", "WBGene00020209", "Q23130", "WBGene00012203" ] }, "reaction_10573170": { "compartment": "compartment_876", "id": "reaction_10573170", "reactome": "R-CEL-9693125", "name": "RHOF binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10573166", "species_10573139" ], "products": [ "species_10573168" ], "modifiers": [], "additional_components": [ "O17905", "WBGene00001490", "Q7JP75", "WBGene00000872", "Q19479", "WBGene00008848", "species_29438", "Q22038", "WBGene00004357", "species_29438", "Q22038", "WBGene00004357", "O17905", "WBGene00001490", "Q7JP75", "WBGene00000872", "Q19479", "WBGene00008848" ] }, "reaction_10573142": { "compartment": "compartment_876", "id": "reaction_10573142", "reactome": "R-CEL-9693111", "name": "RHOF auto-activates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10573137" ], "products": [ "species_29420", "species_10573139" ], "modifiers": [ [ "species_10573137", "catalyst" ] ], "additional_components": [ "species_29420", "Q22038", "WBGene00004357", "species_29438", "Q22038", "WBGene00004357", "species_29420", "Q22038", "WBGene00004357" ] }, "reaction_10573206": { "compartment": "compartment_876", "id": "reaction_10573206", "reactome": "R-CEL-9693282", "name": "RHOF GAPs stimulate RHOF GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10573139" ], "products": [ "species_29372", "species_10573137" ], "modifiers": [ [ "species_10573203", "catalyst" ] ], "additional_components": [ "species_29438", "Q22038", "WBGene00004357", "species_29420", "Q22038", "WBGene00004357", "Q23130", "WBGene00012203" ] }, "reaction_10553794": { "compartment": "compartment_70101", "id": "reaction_10553794", "reactome": "R-CEL-5626507", "name": "IQGAPs bind F-actin, which is inhibited by calmodulin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10523755", "species_10553786" ], "products": [ "species_10553790" ], "modifiers": [ [ "species_10553792", "inhibitor" ] ], "additional_components": [ "P0DM41", "WBGene00000063", "P0DM42", "WBGene00000065", "P10984", "WBGene00000064", "P10986", "WBGene00000066", "species_29358", "species_29438", "Q03206", "ced-10", "Q05062", "WBGene00000390", "O17772", "WBGene00003980", "species_29438", "Q03206", "ced-10", "Q05062", "WBGene00000390", "O17772", "WBGene00003980", "P0DM41", "WBGene00000063", "P0DM42", "WBGene00000065", "P10984", "WBGene00000064", "P10986", "WBGene00000066", "species_29358", "species_74016", "O16305", "WBGene00000552", "P04630", "WBGene00000285", "Q09665", "WBGene00006583", "A0A2C9C3L3", "WBGene00020378", "Q09980", "WBGene00017394", "G5EDZ8", "WBGene00000288", "Q11083", "WBGene00020378", "G5EEG0", "WBGene00000286", "Q18136", "WBGene00006861", "G5EF37", "WBGene00003934", "Q94288", "WBGene00000287", "O02159", "WBGene00020378", "species_29438", "Q03206", "ced-10", "Q05062", "WBGene00000390", "O17772", "WBGene00003980" ] }, "reaction_10553797": { "compartment": "compartment_876", "id": "reaction_10553797", "reactome": "R-CEL-5626549", "name": "IQGAPs bind CALM1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10553786", "species_10515137" ], "products": [ "species_10553792" ], "modifiers": [], "additional_components": [ "species_29438", "Q03206", "ced-10", "Q05062", "WBGene00000390", "O17772", "WBGene00003980", "species_74016", "O16305", "WBGene00000552", "P04630", "WBGene00000285", "Q09665", "WBGene00006583", "A0A2C9C3L3", "WBGene00020378", "Q09980", "WBGene00017394", "G5EDZ8", "WBGene00000288", "Q11083", "WBGene00020378", "G5EEG0", "WBGene00000286", "Q18136", "WBGene00006861", "G5EF37", "WBGene00003934", "Q94288", "WBGene00000287", "O02159", "WBGene00020378", "species_74016", "O16305", "WBGene00000552", "P04630", "WBGene00000285", "Q09665", "WBGene00006583", "A0A2C9C3L3", "WBGene00020378", "Q09980", "WBGene00017394", "G5EDZ8", "WBGene00000288", "Q11083", "WBGene00020378", "G5EEG0", "WBGene00000286", "Q18136", "WBGene00006861", "G5EF37", "WBGene00003934", "Q94288", "WBGene00000287", "O02159", "WBGene00020378", "species_29438", "Q03206", "ced-10", "Q05062", "WBGene00000390", "O17772", "WBGene00003980" ] }, "reaction_10553788": { "compartment": "compartment_70101", "id": "reaction_10553788", "reactome": "R-CEL-5626469", "name": "GTP-bound RAC1 and CDC42 bind IQGAPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10553784", "species_10520664" ], "products": [ "species_10553786" ], "modifiers": [], "additional_components": [ "O17772", "WBGene00003980", "species_29438", "Q03206", "ced-10", "Q05062", "WBGene00000390", "species_29438", "Q03206", "ced-10", "Q05062", "WBGene00000390", "O17772", "WBGene00003980" ] }, "reaction_10553925": { "compartment": "compartment_13949", "id": "reaction_10553925", "reactome": "R-CEL-5627071", "name": "RHOQ positively regulates trafficking of GOPC:CFTR to the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10553905" ], "products": [ "species_10553923" ], "modifiers": [ [ "species_10553905", "catalyst" ] ], "additional_components": [ "Q19625", "WBGene00003412", "Q95QV2", "WBGene00000477", "O18302", "WBGene00014101", "O62422", "WBGene00012532", "Q05062", "WBGene00000390", "species_29438", "O18302", "WBGene00014101", "Q19625", "WBGene00003412", "Q95QV2", "WBGene00000477", "O62422", "WBGene00012532", "Q05062", "WBGene00000390", "species_29438", "Q19625", "WBGene00003412", "Q95QV2", "WBGene00000477", "O18302", "WBGene00014101", "O62422", "WBGene00012532", "Q05062", "WBGene00000390", "species_29438" ] }, "reaction_10553944": { "compartment": "compartment_13949", "id": "reaction_10553944", "reactome": "R-CEL-5627275", "name": "GOPC promotes translocation of CFTR to lysosomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10553892" ], "products": [ "species_10553942" ], "modifiers": [ [ "species_10553892", "catalyst" ] ], "additional_components": [ "Q19625", "WBGene00003412", "Q95QV2", "WBGene00000477", "O18302", "WBGene00014101", "Q95QV2", "WBGene00000477", "Q19625", "WBGene00003412", "O18302", "WBGene00014101", "Q19625", "WBGene00003412", "Q95QV2", "WBGene00000477", "O18302", "WBGene00014101" ] }, "reaction_10554706": { "compartment": "compartment_70101", "id": "reaction_10554706", "reactome": "R-CEL-5666088", "name": "RHOD:GTP recruits DAIPH2-3 to endosomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10554702", "species_10554698" ], "products": [ "species_10554704" ], "modifiers": [], "additional_components": [ "Q22038", "WBGene00004357", "species_29438", "Q7JP75", "WBGene00000872", "Q7JP75", "WBGene00000872", "Q22038", "WBGene00004357", "species_29438" ] }, "reaction_10554612": { "compartment": "compartment_876", "id": "reaction_10554612", "reactome": "R-CEL-5665727", "name": "FMNL2 binds CDC42:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10512279", "species_10554608" ], "products": [ "species_10554610" ], "modifiers": [], "additional_components": [ "Q05062", "WBGene00000390", "species_29438", "P34489", "WBGene00010453", "Q9BL72", "WBGene00021698", "P34489", "WBGene00010453", "Q9BL72", "WBGene00021698", "Q05062", "WBGene00000390", "species_29438" ] }, "reaction_10548325": { "compartment": "compartment_70101", "id": "reaction_10548325", "reactome": "R-CEL-3858495", "name": "DAAM1 recruits GTP-bound RHOA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10548317", "species_10548321" ], "products": [ "species_10548323" ], "modifiers": [], "additional_components": [ "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "D6VPA1", "WBGene00018976", "species_114632", "Q22038", "WBGene00004357", "species_29438", "species_114632", "Q22038", "WBGene00004357", "species_29438", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "D6VPA1", "WBGene00018976" ] }, "reaction_10554694": { "compartment": "compartment_70101", "id": "reaction_10554694", "reactome": "R-CEL-5665989", "name": "DIAPH1 binds RHOA:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10554686", "species_10509488" ], "products": [ "species_10554688" ], "modifiers": [], "additional_components": [ "Q19479", "WBGene00008848", "Q7JP75", "WBGene00000872", "Q22038", "WBGene00004357", "species_29438", "Q22038", "WBGene00004357", "species_29438", "Q19479", "WBGene00008848", "Q7JP75", "WBGene00000872" ] }, "reaction_10554710": { "compartment": "compartment_70101", "id": "reaction_10554710", "reactome": "R-CEL-5666104", "name": "RHOD:GTP:DIAPH2-3 recruits SRC-1 to endosomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10513079", "species_10554704" ], "products": [ "species_10554708" ], "modifiers": [], "additional_components": [ "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q7JP75", "WBGene00000872", "Q22038", "WBGene00004357", "species_29438", "Q7JP75", "WBGene00000872", "Q22038", "WBGene00004357", "species_29438", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635" ] }, "reaction_10554633": { "compartment": "compartment_876", "id": "reaction_10554633", "reactome": "R-CEL-5665802", "name": "SRGAP2 binds RAC1:GTP:FMNL1:profilin:G-actin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10554629", "species_10554624" ], "products": [ "species_10554631" ], "modifiers": [], "additional_components": [ "WBGene00006406", "species_29438", "Q03206", "ced-10", "Q9BL72", "WBGene00021698", "P0DM41", "WBGene00000063", "P0DM42", "WBGene00000065", "P10984", "WBGene00000064", "P10986", "WBGene00000066", "species_29358", "species_29438", "Q03206", "ced-10", "Q9BL72", "WBGene00021698", "P0DM41", "WBGene00000063", "P0DM42", "WBGene00000065", "P10984", "WBGene00000064", "P10986", "WBGene00000066", "species_29358", "Q19370", "WBGene00006406" ] }, "reaction_10548319": { "compartment": "compartment_70101", "id": "reaction_10548319", "reactome": "R-CEL-3858489", "name": "ppDVL binds DAAM1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10548315", "species_10548290" ], "products": [ "species_10548317" ], "modifiers": [], "additional_components": [ "WBGene00018976", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "D6VPA1", "WBGene00018976" ] }, "reaction_10554723": { "compartment": "compartment_876", "id": "reaction_10554723", "reactome": "R-CEL-5666197", "name": "RHOA:GTP:RTKN binds LIN7B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10554719", "species_10519885" ], "products": [ "species_10554721" ], "modifiers": [], "additional_components": [ "Q22038", "WBGene00004357", "species_29438", "Q17777", "WBGene00007409", "WBGene00002996", "Q22038", "WBGene00004357", "species_29438", "Q17777", "WBGene00007409", "A5PEX5", "WBGene00002996" ] }, "reaction_10554732": { "compartment": "compartment_70101", "id": "reaction_10554732", "reactome": "R-CEL-5666216", "name": "RHOA:GTP:RTKN binds TAX1BP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10554719", "species_10554728" ], "products": [ "species_10554730" ], "modifiers": [], "additional_components": [ "Q22038", "WBGene00004357", "species_29438", "Q17777", "WBGene00007409", "WBGene00016678", "Q09506", "WBGene00016678", "Q22038", "WBGene00004357", "species_29438", "Q17777", "WBGene00007409" ] }, "reaction_10559350": { "compartment": "compartment_1222693", "id": "reaction_10559350", "reactome": "R-CEL-6798174", "name": "PIK3C3:PIK3R4 phosphorylates PI to PI3P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1524165" ], "products": [ "species_1629751", "species_29370" ], "modifiers": [ [ "species_10559347", "catalyst" ] ], "additional_components": [ "Q23669", "WBGene00014151", "Q9TXI7", "WBGene00006932" ] }, "reaction_10554803": { "compartment": "compartment_70101", "id": "reaction_10554803", "reactome": "R-CEL-5669158", "name": "NF2 binds PAK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10542001", "species_10520672" ], "products": [ "species_10554801" ], "modifiers": [], "additional_components": [ "WBGene00003593", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "H2KYX3", "WBGene00003593" ] }, "reaction_10542003": { "compartment": "compartment_70101", "id": "reaction_10542003", "reactome": "R-CEL-2029456", "name": "RAC1 and CDC42 activate PAK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10520664", "species_10520672" ], "products": [ "species_10520670", "species_10541994" ], "modifiers": [ [ "species_10542001", "inhibitor" ] ], "additional_components": [ "species_29438", "Q03206", "ced-10", "Q05062", "WBGene00000390", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "species_29438", "Q03206", "ced-10", "Q05062", "WBGene00000390", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "WBGene00003593" ] }, "reaction_10553954": { "compartment": "compartment_70101", "id": "reaction_10553954", "reactome": "R-CEL-5627775", "name": "Autophosphorylation of PAK1,2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10553951", "species_113592" ], "products": [ "species_29370", "species_10520664", "species_10521284" ], "modifiers": [ [ "species_10553951", "catalyst" ] ], "additional_components": [ "species_29438", "Q03206", "ced-10", "Q05062", "WBGene00000390", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "species_29438", "Q03206", "ced-10", "Q05062", "WBGene00000390", "Q17850", "WBGene00003911", "G5EGQ3", "WBGene00003144", "species_29438", "Q03206", "ced-10", "Q05062", "WBGene00000390", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911" ] }, "reaction_10554822": { "compartment": "compartment_70101", "id": "reaction_10554822", "reactome": "R-CEL-5669250", "name": "PAK1 phosphorylates FLNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10554807" ], "products": [ "species_29370", "species_10521268", "species_10554819" ], "modifiers": [ [ "species_10554807", "catalyst" ] ], "additional_components": [ "Q17850", "WBGene00003911", "G5EGQ3", "WBGene00003144", "D0VWL6", "WBGene00016006", "U4PBJ9", "WBGene00022048", "Q17850", "WBGene00003911", "G5EGQ3", "WBGene00003144", "D0VWL6", "WBGene00016006", "U4PBJ9", "WBGene00022048", "Q17850", "WBGene00003911", "G5EGQ3", "WBGene00003144", "D0VWL6", "WBGene00016006", "U4PBJ9", "WBGene00022048" ] }, "reaction_10554809": { "compartment": "compartment_70101", "id": "reaction_10554809", "reactome": "R-CEL-5669240", "name": "FLNA binds PAK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10521268", "species_10554805" ], "products": [ "species_10554807" ], "modifiers": [], "additional_components": [ "Q17850", "WBGene00003911", "G5EGQ3", "WBGene00003144", "D0VWL6", "WBGene00016006", "U4PBJ9", "WBGene00022048", "Q17850", "WBGene00003911", "G5EGQ3", "WBGene00003144", "D0VWL6", "WBGene00016006", "U4PBJ9", "WBGene00022048" ] }, "reaction_10570440": { "compartment": "compartment_70101", "id": "reaction_10570440", "reactome": "R-CEL-8981926", "name": "RAC1 and CDC42 activate PAK3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10520684", "species_10520664" ], "products": [ "species_10553949", "species_10520682" ], "modifiers": [], "additional_components": [ "Q17850", "WBGene00003911", "species_29438", "Q03206", "ced-10", "Q05062", "WBGene00000390", "species_29438", "Q03206", "ced-10", "Q05062", "WBGene00000390", "Q17850", "WBGene00003911", "WBGene00003911" ] }, "reaction_10570442": { "compartment": "compartment_70101", "id": "reaction_10570442", "reactome": "R-CEL-8981931", "name": "RAC1 and CDC42 activate PAK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10520680", "species_10520664" ], "products": [ "species_10553947", "species_10520678" ], "modifiers": [], "additional_components": [ "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "species_29438", "Q03206", "ced-10", "Q05062", "WBGene00000390", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "species_29438", "Q03206", "ced-10", "Q05062", "WBGene00000390", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911" ] }, "reaction_10554783": { "compartment": "compartment_70101", "id": "reaction_10554783", "reactome": "R-CEL-5668932", "name": "PAK2 phosphorylates myosin regulatory light chain (MRLC)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10554760" ], "products": [ "species_10554780", "species_29370" ], "modifiers": [ [ "species_10521278", "catalyst" ] ], "additional_components": [ "Q20641", "WBGene00003776", "G5EBY3", "WBGene00003777", "P19625", "WBGene00003369", "P19626", "WBGene00003370", "Q09510", "WBGene00003372", "Q20238", "WBGene00009585", "Q21201", "WBGene00010554", "Q69Z12", "WBGene00023451", "Q9XVI9", "WBGene00011734", "P53014", "WBGene00003371", "Q20641", "WBGene00003776", "G5EBY3", "WBGene00003777", "Q20238", "WBGene00009585", "Q21201", "WBGene00010554", "Q69Z12", "WBGene00023451", "Q9XVI9", "WBGene00011734", "P53014", "WBGene00003371", "P19625", "WBGene00003369", "P19626", "WBGene00003370", "Q09510", "WBGene00003372", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911" ] }, "reaction_10554799": { "compartment": "compartment_70101", "id": "reaction_10554799", "reactome": "R-CEL-5668947", "name": "PAK1 phosphorylates myosin phosphatase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10554791" ], "products": [ "species_10554796", "species_29370" ], "modifiers": [ [ "species_10521268", "catalyst" ] ], "additional_components": [ "Q27497", "WBGene00001747", "G5ECD7", "WBGene00003196", "Q27497", "WBGene00001747", "G5ECD7", "WBGene00003196", "Q17850", "WBGene00003911", "G5EGQ3", "WBGene00003144" ] }, "reaction_10554832": { "compartment": "compartment_70101", "id": "reaction_10554832", "reactome": "R-CEL-5671737", "name": "p-T774-PKN1 binds CDC25C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10553254", "species_10509856" ], "products": [ "species_10554830" ], "modifiers": [], "additional_components": [ "WBGene00009793", "WBGene00000389", "Q21762", "WBGene00000389", "A0A4V0ILM7", "WBGene00009793" ] }, "reaction_10507073": { "compartment": "compartment_70101", "id": "reaction_10507073", "reactome": "R-CEL-75016", "name": "Association of p-S216-CDC25C with 14-3-3 proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10507069", "species_10507019" ], "products": [ "species_10507071" ], "modifiers": [], "additional_components": [ "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "WBGene00000389", "Q21762", "WBGene00000389", "P41932", "WBGene00003920", "Q20655", "WBGene00001502" ] }, "reaction_10554835": { "compartment": "compartment_70101", "id": "reaction_10554835", "reactome": "R-CEL-5671749", "name": "p-T774-PKN1 phosphorylates CDC25C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10554830", "species_113592" ], "products": [ "species_10507019", "species_29370", "species_10553254" ], "modifiers": [ [ "species_10554830", "catalyst" ] ], "additional_components": [ "Q21762", "WBGene00000389", "A0A4V0ILM7", "WBGene00009793", "WBGene00000389", "WBGene00009793", "Q21762", "WBGene00000389", "A0A4V0ILM7", "WBGene00009793" ] }, "reaction_10554850": { "compartment": "compartment_70101", "id": "reaction_10554850", "reactome": "R-CEL-5671772", "name": "p-T38-PPP1R14A binds MLCP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10554843", "species_10554791" ], "products": [ "species_10554848" ], "modifiers": [], "additional_components": [ "WBGene00010109", "Q27497", "WBGene00001747", "G5ECD7", "WBGene00003196", "Q27497", "WBGene00001747", "G5ECD7", "WBGene00003196", "Q7YX00", "WBGene00010109" ] }, "reaction_10553239": { "compartment": "compartment_876", "id": "reaction_10553239", "reactome": "R-CEL-5623622", "name": "RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10553227", "species_10553235" ], "products": [ "species_10553237" ], "modifiers": [], "additional_components": [ "WBGene00009793", "Q22038", "WBGene00004357", "species_29438", "Q22038", "WBGene00004357", "species_29438", "A0A4V0ILM7", "WBGene00009793" ] }, "reaction_10553243": { "compartment": "compartment_876", "id": "reaction_10553243", "reactome": "R-CEL-5623632", "name": "RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10553237", "species_10508530" ], "products": [ "species_10553241" ], "modifiers": [], "additional_components": [ "Q22038", "WBGene00004357", "species_29438", "A0A4V0ILM7", "WBGene00009793", "Q9UA62", "WBGene00021022", "species_179838", "Q9UA62", "WBGene00021022", "species_179838", "Q22038", "WBGene00004357", "species_29438", "A0A4V0ILM7", "WBGene00009793" ] }, "reaction_10553263": { "compartment": "compartment_70101", "id": "reaction_10553263", "reactome": "R-CEL-5623667", "name": "PDPK1 phosphorylates PKN1,2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10553241" ], "products": [ "species_29370", "species_10553254", "species_10553235", "species_10508530" ], "modifiers": [ [ "species_10553241", "catalyst" ] ], "additional_components": [ "Q9UA62", "WBGene00021022", "species_179838", "Q22038", "WBGene00004357", "species_29438", "A0A4V0ILM7", "WBGene00009793", "WBGene00009793", "Q22038", "WBGene00004357", "species_29438", "Q9UA62", "WBGene00021022", "species_179838", "Q9UA62", "WBGene00021022", "species_179838", "Q22038", "WBGene00004357", "species_29438", "A0A4V0ILM7", "WBGene00009793" ] }, "reaction_10553760": { "compartment": "compartment_7660", "id": "reaction_10553760", "reactome": "R-CEL-5625797", "name": "KDM4C demethylates Me3K-10-H3 associated with KLK2 and KLK3 promoters", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113671", "species_113685", "species_10553745" ], "products": [ "species_10553757", "species_29478", "species_10549605", "species_159942", "species_159939" ], "modifiers": [ [ "species_10553745", "catalyst" ] ], "additional_components": [ "Q9U297", "WBGene00012982", "A0A4V0ILM7", "WBGene00009793", "species_469662", "CHEBI:29117", "species_193057", "species_193079", "P62784", "WBGene00001875", "K7ZUH9", "WBGene00001914", "Q10453", "WBGene00001945", "A0A4V0ILM7", "WBGene00009793", "species_469662", "CHEBI:29117", "species_193057", "species_193079", "P62784", "WBGene00001875", "Q10453", "WBGene00001945", "K7ZUH9", "WBGene00001914", "WBGene00012982", "Q9U297", "WBGene00012982", "A0A4V0ILM7", "WBGene00009793", "species_469662", "CHEBI:29117", "species_193057", "species_193079", "P62784", "WBGene00001875", "K7ZUH9", "WBGene00001914", "Q10453", "WBGene00001945" ] }, "reaction_10553747": { "compartment": "compartment_7660", "id": "reaction_10553747", "reactome": "R-CEL-5625796", "name": "Demethylase KDM4C binds KLK2 and KLK3 promoters", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10553740", "species_10549605" ], "products": [ "species_10553745" ], "modifiers": [], "additional_components": [ "A0A4V0ILM7", "WBGene00009793", "species_469662", "CHEBI:29117", "species_193057", "species_193079", "P62784", "WBGene00001875", "K7ZUH9", "WBGene00001914", "Q10453", "WBGene00001945", "WBGene00012982", "Q9U297", "WBGene00012982", "A0A4V0ILM7", "WBGene00009793", "species_469662", "CHEBI:29117", "species_193057", "species_193079", "P62784", "WBGene00001875", "K7ZUH9", "WBGene00001914", "Q10453", "WBGene00001945" ] }, "reaction_10553743": { "compartment": "compartment_7660", "id": "reaction_10553743", "reactome": "R-CEL-5625784", "name": "PKN1 phosphorylates histone 3 of nucleosomes associate with KLK2 and KLK3 promoters", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10553726", "species_29358" ], "products": [ "species_113582", "species_10553740" ], "modifiers": [ [ "species_10553726", "catalyst" ] ], "additional_components": [ "A0A4V0ILM7", "WBGene00009793", "species_469662", "CHEBI:29117", "species_193057", "species_193079", "P62784", "WBGene00001875", "Q10453", "WBGene00001945", "K7ZUH9", "WBGene00001914", "A0A4V0ILM7", "WBGene00009793", "species_469662", "CHEBI:29117", "species_193057", "species_193079", "P62784", "WBGene00001875", "K7ZUH9", "WBGene00001914", "Q10453", "WBGene00001945", "A0A4V0ILM7", "WBGene00009793", "species_469662", "CHEBI:29117", "species_193057", "species_193079", "P62784", "WBGene00001875", "Q10453", "WBGene00001945", "K7ZUH9", "WBGene00001914" ] }, "reaction_10554846": { "compartment": "compartment_70101", "id": "reaction_10554846", "reactome": "R-CEL-5671763", "name": "p-T774-PKN1 phosphorylates PPP1R14A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10554840" ], "products": [ "species_10554843", "species_29370" ], "modifiers": [ [ "species_10553254", "catalyst" ] ], "additional_components": [ "WBGene00010109", "WBGene00010109", "WBGene00009793" ] }, "reaction_10542752": { "compartment": "compartment_876", "id": "reaction_10542752", "reactome": "R-CEL-2130194", "name": "ABL phosphorylates WAVEs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10542749", "species_113592" ], "products": [ "species_29370", "species_10542068" ], "modifiers": [ [ "species_10519289", "catalyst" ] ], "additional_components": [ "species_29438", "Q03206", "ced-10", "A5Z2X2", "WBGene00303007", "O44518", "WBGene00001579", "P55163", "WBGene00001580", "Q9XVK6", "WBGene00006958", "Q10929", "WBGene00015146", "species_179838", "species_29438", "Q03206", "ced-10", "A5Z2X2", "WBGene00303007", "O44518", "WBGene00001579", "P55163", "WBGene00001580", "Q10929", "WBGene00015146", "Q9XVK6", "WBGene00006958", "species_179838", "WBGene00000018" ] }, "reaction_10542112": { "compartment": "compartment_70101", "id": "reaction_10542112", "reactome": "R-CEL-2029473", "name": "Branching and elongation of mother and daughter filaments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10542110", "species_10515381" ], "products": [ "species_10537825" ], "modifiers": [], "additional_components": [ "P0DM41", "WBGene00000063", "P0DM42", "WBGene00000065", "P10984", "WBGene00000064", "P10986", "WBGene00000066", "species_29358", "species_113582", "P58798", "WBGene00000204", "A0A3P6PCS5", "WBGene00000201", "Q9N4I0", "WBGene00000199", "Q8WTM6", "WBGene00021170", "P53489", "WBGene00000200", "Q9XWV3", "WBGene00000203", "O61861", "WBGene00000205", "P91167", "WBGene00016729", "P0DM41", "WBGene00000063", "P0DM42", "WBGene00000065", "P10984", "WBGene00000064", "P10986", "WBGene00000066", "species_29358", "P0DM41", "WBGene00000063", "P0DM42", "WBGene00000065", "P10984", "WBGene00000064", "P10986", "WBGene00000066", "species_29358", "P58798", "WBGene00000204", "A0A3P6PCS5", "WBGene00000201", "Q9N4I0", "WBGene00000199", "Q8WTM6", "WBGene00021170", "P53489", "WBGene00000200", "Q9XWV3", "WBGene00000203", "O61861", "WBGene00000205", "P91167", "WBGene00016729" ] }, "reaction_10542085": { "compartment": "compartment_70101", "id": "reaction_10542085", "reactome": "R-CEL-2029469", "name": "p-ERK phosphorylates WAVEs and ABI", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10542068" ], "products": [ "species_29370", "species_10542054" ], "modifiers": [ [ "species_10542082", "catalyst" ] ], "additional_components": [ "species_29438", "Q03206", "ced-10", "A5Z2X2", "WBGene00303007", "O44518", "WBGene00001579", "P55163", "WBGene00001580", "Q10929", "WBGene00015146", "Q9XVK6", "WBGene00006958", "species_179838", "species_29438", "Q03206", "ced-10", "A5Z2X2", "WBGene00303007", "O44518", "WBGene00001579", "P55163", "WBGene00001580", "Q9XVK6", "WBGene00006958", "Q10929", "WBGene00015146", "species_179838", "P39745", "WBGene00003401" ] }, "reaction_10543483": { "compartment": "compartment_70101", "id": "reaction_10543483", "reactome": "R-CEL-2197690", "name": "Detachment of WASP/WAVE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10542074" ], "products": [ "species_10542110", "species_10542070" ], "modifiers": [], "additional_components": [ "P0DM41", "WBGene00000063", "P0DM42", "WBGene00000065", "P10984", "WBGene00000064", "P10986", "WBGene00000066", "species_29358", "species_29438", "Q03206", "ced-10", "A5Z2X2", "WBGene00303007", "O44518", "WBGene00001579", "P55163", "WBGene00001580", "Q10929", "WBGene00015146", "Q9XVK6", "WBGene00006958", "species_179838", "P58798", "WBGene00000204", "A0A3P6PCS5", "WBGene00000201", "Q9N4I0", "WBGene00000199", "Q8WTM6", "WBGene00021170", "P53489", "WBGene00000200", "Q9XWV3", "WBGene00000203", "O61861", "WBGene00000205", "P91167", "WBGene00016729", "P0DM41", "WBGene00000063", "P0DM42", "WBGene00000065", "P10984", "WBGene00000064", "P10986", "WBGene00000066", "species_29358", "species_113582", "P58798", "WBGene00000204", "A0A3P6PCS5", "WBGene00000201", "Q9N4I0", "WBGene00000199", "Q8WTM6", "WBGene00021170", "P53489", "WBGene00000200", "Q9XWV3", "WBGene00000203", "O61861", "WBGene00000205", "P91167", "WBGene00016729", "species_29438", "Q03206", "ced-10", "A5Z2X2", "WBGene00303007", "O44518", "WBGene00001579", "P55163", "WBGene00001580", "Q10929", "WBGene00015146", "Q9XVK6", "WBGene00006958", "species_179838" ] }, "reaction_10542076": { "compartment": "compartment_70101", "id": "reaction_10542076", "reactome": "R-CEL-2029466", "name": "(WASPs, WAVE):G-actin:ARP2/3 binds F-actin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10523755", "species_10542072" ], "products": [ "species_10542074" ], "modifiers": [], "additional_components": [ "P0DM41", "WBGene00000063", "P0DM42", "WBGene00000065", "P10984", "WBGene00000064", "P10986", "WBGene00000066", "species_29358", "P0DM41", "WBGene00000063", "P0DM42", "WBGene00000065", "P10984", "WBGene00000064", "P10986", "WBGene00000066", "species_29358", "species_29438", "Q03206", "ced-10", "A5Z2X2", "WBGene00303007", "O44518", "WBGene00001579", "P55163", "WBGene00001580", "Q10929", "WBGene00015146", "Q9XVK6", "WBGene00006958", "species_179838", "P58798", "WBGene00000204", "A0A3P6PCS5", "WBGene00000201", "Q9N4I0", "WBGene00000199", "Q8WTM6", "WBGene00021170", "P53489", "WBGene00000200", "Q9XWV3", "WBGene00000203", "O61861", "WBGene00000205", "P91167", "WBGene00016729", "P0DM41", "WBGene00000063", "P0DM42", "WBGene00000065", "P10984", "WBGene00000064", "P10986", "WBGene00000066", "species_29358", "species_29438", "Q03206", "ced-10", "A5Z2X2", "WBGene00303007", "O44518", "WBGene00001579", "P55163", "WBGene00001580", "Q10929", "WBGene00015146", "Q9XVK6", "WBGene00006958", "species_179838", "P58798", "WBGene00000204", "A0A3P6PCS5", "WBGene00000201", "Q9N4I0", "WBGene00000199", "Q8WTM6", "WBGene00021170", "P53489", "WBGene00000200", "Q9XWV3", "WBGene00000203", "O61861", "WBGene00000205", "P91167", "WBGene00016729" ] }, "reaction_10571243": { "compartment": "compartment_984", "id": "reaction_10571243", "reactome": "R-CEL-9014052", "name": "TXLNA (IL14) binds syntaxin3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10525375", "species_10571239" ], "products": [ "species_10571241" ], "modifiers": [], "additional_components": [ "WBGene00011917", "Q20024", "WBGene00006371", "Q20574", "WBGene00006372", "O16000", "WBGene00006798", "Q20024", "WBGene00006371", "Q20574", "WBGene00006372", "O16000", "WBGene00006798", "Q22666", "WBGene00011917" ] }, "reaction_10525389": { "compartment": "compartment_984", "id": "reaction_10525389", "reactome": "R-CEL-449117", "name": "TXLNA (IL14) binds syntaxin1A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10525375", "species_10516749" ], "products": [ "species_10525377" ], "modifiers": [ [ "species_10525387", "inhibitor" ] ], "additional_components": [ "WBGene00011917", "WBGene00006798", "O16000", "WBGene00006798", "Q22666", "WBGene00011917", "G5EEN8", "WBGene00006454", "A5PEW5", "WBGene00004364", "O44412", "WBGene00020298", "P34815", "WBGene00006757", "O16000", "WBGene00006798" ] }, "reaction_10528533": { "compartment": "compartment_70101", "id": "reaction_10528533", "reactome": "R-CEL-912734", "name": "CBL:CRKL binds RAPGEF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10528524", "species_10528529" ], "products": [ "species_10528531" ], "modifiers": [], "additional_components": [ "Q19019", "WBGene00004829", "Q9NHC3", "WBGene00000416", "Q95XA9", "WBGene00021238", "WBGene00021320", "H2KZX7", "WBGene00021320", "Q19019", "WBGene00004829", "Q9NHC3", "WBGene00000416", "Q95XA9", "WBGene00021238" ] }, "reaction_10528518": { "compartment": "compartment_70101", "id": "reaction_10528518", "reactome": "R-CEL-912627", "name": "CBL ubiquitinates PI3K", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10528462", "species_10528505" ], "products": [ "species_10528516" ], "modifiers": [], "additional_components": [ "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "P29355", "WBGene00004774", "G5EDP9", "WBGene00000001", "Q94125", "WBGene00000090", "Q19019", "WBGene00004829", "P37165", "WBGene00006725", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "Q94125", "WBGene00000090", "G5EDP9", "WBGene00000001", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "P29355", "WBGene00004774", "Q19019", "WBGene00004829" ] }, "reaction_10528535": { "compartment": "compartment_70101", "id": "reaction_10528535", "reactome": "R-CEL-912790", "name": "CBL binds CRK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10520269", "species_10528460" ], "products": [ "species_10528524" ], "modifiers": [], "additional_components": [ "Q9NHC3", "WBGene00000416", "Q95XA9", "WBGene00021238", "WBGene00004829", "Q19019", "WBGene00004829", "Q9NHC3", "WBGene00000416", "Q95XA9", "WBGene00021238" ] }, "reaction_10528266": { "compartment": "compartment_70101", "id": "reaction_10528266", "reactome": "R-CEL-879917", "name": "CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10506892", "species_10512267", "species_10506871", "species_10528262" ], "products": [ "species_10528264" ], "modifiers": [], "additional_components": [ "G5EDP9", "WBGene00000001", "Q94125", "WBGene00000090", "WBGene00004829", "WBGene00004774", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "P29355", "WBGene00004774", "Q19019", "WBGene00004829", "G5EDP9", "WBGene00000001", "Q94125", "WBGene00000090" ] }, "reaction_10528522": { "compartment": "compartment_70101", "id": "reaction_10528522", "reactome": "R-CEL-912727", "name": "CBL binds VAV", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10528460", "species_10516075" ], "products": [ "species_10528520" ], "modifiers": [], "additional_components": [ "WBGene00004829", "WBGene00006887", "Q45FX5", "WBGene00006887", "Q19019", "WBGene00004829" ] }, "reaction_10531907": { "compartment": "compartment_70101", "id": "reaction_10531907", "reactome": "R-CEL-1112587", "name": "STAT1 and STAT3 dimers translocate to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10531891" ], "products": [ "species_10531905" ], "modifiers": [], "additional_components": [ "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111" ] }, "reaction_10531893": { "compartment": "compartment_70101", "id": "reaction_10531893", "reactome": "R-CEL-1112538", "name": "Phosphorylated STAT1, STAT3 form dimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10531885" ], "products": [ "species_10531891" ], "modifiers": [], "additional_components": [ "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111" ] }, "reaction_10573100": { "compartment": "compartment_984", "id": "reaction_10573100", "reactome": "R-CEL-9681294", "name": "IL6R binds IL6R inhibitors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10573096", "species_9715042" ], "products": [ "species_10573098" ], "modifiers": [], "additional_components": [ "WBGene00002915", "Q9UB28", "WBGene00002915" ] }, "reaction_10558097": { "compartment": "compartment_70101", "id": "reaction_10558097", "reactome": "R-CEL-6784765", "name": "p-Y705-STAT3 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10531883" ], "products": [ "species_10531887" ], "modifiers": [], "additional_components": [ "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111" ] }, "reaction_10558095": { "compartment": "compartment_70101", "id": "reaction_10558095", "reactome": "R-CEL-6784763", "name": "p-Y705-STAT3 dimer translocates from cytosol to nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10531887" ], "products": [ "species_10531903" ], "modifiers": [], "additional_components": [ "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111" ] }, "reaction_10570566": { "compartment": "compartment_70101", "id": "reaction_10570566", "reactome": "R-CEL-8985943", "name": "p-Y701-STAT1 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10570562" ], "products": [ "species_10570564" ], "modifiers": [], "additional_components": [ "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251" ] }, "reaction_10570584": { "compartment": "compartment_70101", "id": "reaction_10570584", "reactome": "R-CEL-8985981", "name": "p-Y701-STAT1:p-Y705-STAT3 translocates from the cytosol to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10570572" ], "products": [ "species_10570582" ], "modifiers": [], "additional_components": [ "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251" ] }, "reaction_10570570": { "compartment": "compartment_70101", "id": "reaction_10570570", "reactome": "R-CEL-8985950", "name": "p-Y649-STAT5A, p-STAT5B dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10570515" ], "products": [ "species_10570568" ], "modifiers": [], "additional_components": [] }, "reaction_10570574": { "compartment": "compartment_70101", "id": "reaction_10570574", "reactome": "R-CEL-8985966", "name": "p-Y701-STAT1 binds p-Y705-STAT3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10570521", "species_10570562" ], "products": [ "species_10570572" ], "modifiers": [], "additional_components": [ "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251" ] }, "reaction_10570611": { "compartment": "compartment_70101", "id": "reaction_10570611", "reactome": "R-CEL-8987007", "name": "p-STAT1 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10569000" ], "products": [ "species_10570609" ], "modifiers": [], "additional_components": [ "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111" ] }, "reaction_10570643": { "compartment": "compartment_70101", "id": "reaction_10570643", "reactome": "R-CEL-8987218", "name": "p-STAT1 dimer translocates from the cytosol to the nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10570609" ], "products": [ "species_10570641" ], "modifiers": [], "additional_components": [ "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111" ] }, "reaction_10570629": { "compartment": "compartment_70101", "id": "reaction_10570629", "reactome": "R-CEL-8987052", "name": "p-STAT3 dimer translocates from cytosol to nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10570619" ], "products": [ "species_10570627" ], "modifiers": [], "additional_components": [ "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111" ] }, "reaction_10570633": { "compartment": "compartment_70101", "id": "reaction_10570633", "reactome": "R-CEL-8987214", "name": "p-STAT3 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10570617" ], "products": [ "species_10570619" ], "modifiers": [], "additional_components": [ "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111" ] }, "reaction_10558321": { "compartment": "compartment_70101", "id": "reaction_10558321", "reactome": "R-CEL-6788622", "name": "p-Y-STATs dimerize", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10558317" ], "products": [ "species_10558319" ], "modifiers": [], "additional_components": [ "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111" ] }, "reaction_10558499": { "compartment": "compartment_17957", "id": "reaction_10558499", "reactome": "R-CEL-6790038", "name": "Expression of HSP90B1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [], "products": [ "species_10558497" ], "modifiers": [ [ "species_10531903", "catalyst" ] ], "additional_components": [ "WBGene00011480", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111" ] }, "reaction_10558325": { "compartment": "compartment_70101", "id": "reaction_10558325", "reactome": "R-CEL-6788623", "name": "p-Y-STATs translocate to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10558319" ], "products": [ "species_10558323" ], "modifiers": [], "additional_components": [ "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111" ] }, "reaction_10558148": { "compartment": "compartment_70101", "id": "reaction_10558148", "reactome": "R-CEL-6786097", "name": "p-Y705-STAT3, p-Y641-STAT6 dimerise", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10558142" ], "products": [ "species_10558146" ], "modifiers": [], "additional_components": [ "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111" ] }, "reaction_10558206": { "compartment": "compartment_70101", "id": "reaction_10558206", "reactome": "R-CEL-6786293", "name": "p-Y705-STAT3 dimer, p-Y641-STAT6 dimer translocate to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10558146" ], "products": [ "species_10558204" ], "modifiers": [], "additional_components": [ "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111" ] }, "reaction_10570774": { "compartment": "compartment_70101", "id": "reaction_10570774", "reactome": "R-CEL-9009072", "name": "STAT3 phosphorylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10519913" ], "products": [ "species_29370", "species_10570521" ], "modifiers": [], "additional_components": [ "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111" ] }, "reaction_10526186": { "compartment": "compartment_70101", "id": "reaction_10526186", "reactome": "R-CEL-451418", "name": "Pellino ubiquitinates IRAK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10526177" ], "products": [ "species_10526183" ], "modifiers": [ [ "species_10526177", "catalyst" ] ], "additional_components": [ "Q22967", "WBGene00017766", "Q95XX0", "WBGene00006708", "O45495", "WBGene00006730", "P37165", "WBGene00006725", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "Q22967", "WBGene00017766", "Q95XX0", "WBGene00006708", "O45495", "WBGene00006730", "Q22967", "WBGene00017766", "Q95XX0", "WBGene00006708", "O45495", "WBGene00006730", "P37165", "WBGene00006725", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727" ] }, "reaction_10525239": { "compartment": "compartment_70101", "id": "reaction_10525239", "reactome": "R-CEL-448673", "name": "Formation of caspase-1 p10/p20 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10525229", "species_10525235" ], "products": [ "species_10525237" ], "modifiers": [], "additional_components": [ "G5EBM1", "WBGene00000819", "P42573", "WBGene00000417", "P42573", "WBGene00000417", "G5EBM1", "WBGene00000819", "P42573", "WBGene00000417", "G5EBM1", "WBGene00000819" ] }, "reaction_10525261": { "compartment": "compartment_70101", "id": "reaction_10525261", "reactome": "R-CEL-448702", "name": "Caspase-1 active tetramer formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10525237" ], "products": [ "species_10525259" ], "modifiers": [], "additional_components": [ "P42573", "WBGene00000417", "G5EBM1", "WBGene00000819", "P42573", "WBGene00000417", "G5EBM1", "WBGene00000819" ] }, "reaction_10570684": { "compartment": "compartment_984", "id": "reaction_10570684", "reactome": "R-CEL-9008043", "name": "MAPK8 phosphorylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10510931" ], "products": [ "species_29370", "species_10510951" ], "modifiers": [], "additional_components": [ "WBGene00002178", "WBGene00002178" ] }, "reaction_10533055": { "compartment": "compartment_984", "id": "reaction_10533055", "reactome": "R-CEL-1362465", "name": "GHBP binds GHR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10530700", "species_10533051" ], "products": [ "species_10533053" ], "modifiers": [], "additional_components": [ "WBGene00002915", "WBGene00002915", "Q9UB28", "WBGene00002915" ] }, "reaction_10543479": { "compartment": "compartment_70101", "id": "reaction_10543479", "reactome": "R-CEL-2187401", "name": "MTMR4 dephosphorylates SMAD2/3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10543476" ], "products": [ "species_29372", "species_10543474", "species_10511457" ], "modifiers": [ [ "species_10543476", "catalyst" ] ], "additional_components": [ "Q22712", "WBGene00003476", "Q21733", "WBGene00000904", "WBGene00003476", "WBGene00000904", "Q22712", "WBGene00003476", "Q21733", "WBGene00000904" ] }, "reaction_10543464": { "compartment": "compartment_70101", "id": "reaction_10543464", "reactome": "R-CEL-2187368", "name": "STUB1 (CHIP) ubiquitinates SMAD3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502375", "species_10543459" ], "products": [ "species_10543461", "species_10530864" ], "modifiers": [ [ "species_10543459", "catalyst" ] ], "additional_components": [ "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "G5ECY6", "WBGene00000500", "Q21733", "WBGene00000904", "Q21733", "WBGene00000904", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "WBGene00000500", "G5ECY6", "WBGene00000500", "Q21733", "WBGene00000904" ] }, "reaction_10543481": { "compartment": "compartment_70101", "id": "reaction_10543481", "reactome": "R-CEL-2187405", "name": "MTMR4 binds phosphorylated SMAD2/3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10511411", "species_10543474" ], "products": [ "species_10543476" ], "modifiers": [], "additional_components": [ "WBGene00000904", "WBGene00003476", "Q22712", "WBGene00003476", "Q21733", "WBGene00000904" ] }, "reaction_10543466": { "compartment": "compartment_70101", "id": "reaction_10543466", "reactome": "R-CEL-2187375", "name": "SMAD3 binds STUB1 (CHIP)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10511459", "species_10530864" ], "products": [ "species_10543459" ], "modifiers": [], "additional_components": [ "WBGene00000904", "WBGene00000500", "G5ECY6", "WBGene00000500", "Q21733", "WBGene00000904" ] }, "reaction_10543468": { "compartment": "compartment_70101", "id": "reaction_10543468", "reactome": "R-CEL-2187382", "name": "Degradation of ubiquitinated SMAD3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10543461" ], "products": [], "modifiers": [], "additional_components": [ "Q21733", "WBGene00000904", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727" ] }, "reaction_10543389": { "compartment": "compartment_70101", "id": "reaction_10543389", "reactome": "R-CEL-2176452", "name": "Degradation of ubiquitinated SMAD2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10543387" ], "products": [], "modifiers": [], "additional_components": [ "Q21733", "WBGene00000904", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727" ] }, "reaction_10543310": { "compartment": "compartment_876", "id": "reaction_10543310", "reactome": "R-CEL-2169046", "name": "Degradation of TGF-beta receptor complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10543308" ], "products": [], "modifiers": [], "additional_components": [ "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "P20792", "WBGene00000897", "G5EBY8", "WBGene00006852", "G5EEL5", "WBGene00000936", "G5EDS9", "WBGene00006445" ] }, "reaction_10512054": { "compartment": "compartment_17963", "id": "reaction_10512054", "reactome": "R-CEL-177107", "name": "Secretion and activation of the latent large complex of TGF-beta-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10511397" ], "products": [ "species_10511431" ], "modifiers": [], "additional_components": [ "G5EEL5", "WBGene00000936", "G5EBY8", "WBGene00006852", "G5EBY8", "WBGene00006852", "G5EEL5", "WBGene00000936" ] }, "reaction_10511399": { "compartment": "compartment_20699", "id": "reaction_10511399", "reactome": "R-CEL-170844", "name": "Latent TGF-beta-1 is cleaved by furin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10511389" ], "products": [ "species_10511397" ], "modifiers": [ [ "species_10510315", "catalyst" ] ], "additional_components": [ "G5EBY8", "WBGene00006852", "G5EEL5", "WBGene00000936", "G5EEL5", "WBGene00000936", "G5EBY8", "WBGene00006852", "WBGene00002232" ] }, "reaction_10511464": { "compartment": "compartment_171062", "id": "reaction_10511464", "reactome": "R-CEL-170868", "name": "Activated type I receptor phosphorylates SMAD2/3 directly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10511461" ], "products": [ "species_10511451", "species_29370" ], "modifiers": [ [ "species_10511461", "catalyst" ] ], "additional_components": [ "Q21733", "WBGene00000904", "P20792", "WBGene00000897", "G5EBY8", "WBGene00006852", "G5EEL5", "WBGene00000936", "H2KZI9", "WBGene00000101", "Q21733", "WBGene00000904", "P20792", "WBGene00000897", "G5EBY8", "WBGene00006852", "G5EEL5", "WBGene00000936", "H2KZI9", "WBGene00000101", "Q21733", "WBGene00000904", "P20792", "WBGene00000897", "G5EBY8", "WBGene00006852", "G5EEL5", "WBGene00000936", "H2KZI9", "WBGene00000101" ] }, "reaction_10511419": { "compartment": "compartment_70101", "id": "reaction_10511419", "reactome": "R-CEL-170847", "name": "Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10511404", "species_10511411" ], "products": [ "species_10511417" ], "modifiers": [], "additional_components": [ "WBGene00004858", "WBGene00000904", "Q21733", "WBGene00000904", "P45897", "WBGene00004858" ] }, "reaction_10511455": { "compartment": "compartment_17941", "id": "reaction_10511455", "reactome": "R-CEL-170850", "name": "Phosphorylated SMAD2/3 dissociates from TGFBR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10511451" ], "products": [ "species_10511453", "species_10511411" ], "modifiers": [], "additional_components": [ "Q21733", "WBGene00000904", "P20792", "WBGene00000897", "G5EBY8", "WBGene00006852", "G5EEL5", "WBGene00000936", "H2KZI9", "WBGene00000101", "P20792", "WBGene00000897", "G5EBY8", "WBGene00006852", "G5EEL5", "WBGene00000936", "H2KZI9", "WBGene00000101", "WBGene00000904" ] }, "reaction_10511520": { "compartment": "compartment_70101", "id": "reaction_10511520", "reactome": "R-CEL-173488", "name": "The SMAD2/3:SMAD4 complex transfers to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10511417" ], "products": [ "species_10511518" ], "modifiers": [], "additional_components": [ "Q21733", "WBGene00000904", "P45897", "WBGene00004858", "P45897", "WBGene00004858", "Q21733", "WBGene00000904" ] }, "reaction_10543457": { "compartment": "compartment_7660", "id": "reaction_10543457", "reactome": "R-CEL-2187309", "name": "SMAD2/3:SMAD4 heterotrimer binds SP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10511518", "species_10543453" ], "products": [ "species_10543455" ], "modifiers": [], "additional_components": [ "P45897", "WBGene00004858", "Q21733", "WBGene00000904", "WBGene00012735", "Q9XW26", "WBGene00012735", "P45897", "WBGene00004858", "Q21733", "WBGene00000904" ] }, "reaction_10542739": { "compartment": "compartment_7660", "id": "reaction_10542739", "reactome": "R-CEL-2127257", "name": "SMAD2/3:SMAD4 heterotrimer forms a complex with RBL1, E2F4/5 and DP1/2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10511518", "species_10532108" ], "products": [ "species_10542737" ], "modifiers": [], "additional_components": [ "P45897", "WBGene00004858", "Q21733", "WBGene00000904", "G5EF11", "WBGene00001161", "G5EDT1", "WBGene00003020", "Q22703", "WBGene00001061", "G5EF11", "WBGene00001161", "G5EDT1", "WBGene00003020", "Q22703", "WBGene00001061", "P45897", "WBGene00004858", "Q21733", "WBGene00000904" ] }, "reaction_10543448": { "compartment": "compartment_7660", "id": "reaction_10543448", "reactome": "R-CEL-2186780", "name": "Degradation of Ub-SMAD7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10543446" ], "products": [], "modifiers": [], "additional_components": [ "G5EDS9", "WBGene00006445", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725" ] }, "reaction_10542699": { "compartment": "compartment_70101", "id": "reaction_10542699", "reactome": "R-CEL-2106579", "name": "WWTR1:SMAD translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10542170" ], "products": [ "species_10542697" ], "modifiers": [], "additional_components": [ "Q21733", "WBGene00000904", "P45897", "WBGene00004858", "Q19404", "WBGene00008748", "Q19404", "WBGene00008748", "P45897", "WBGene00004858", "Q21733", "WBGene00000904" ] }, "reaction_10543404": { "compartment": "compartment_7660", "id": "reaction_10543404", "reactome": "R-CEL-2176475", "name": "Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10511518" ], "products": [ "species_113582", "species_10543397" ], "modifiers": [ [ "species_10543401", "catalyst" ] ], "additional_components": [ "P45897", "WBGene00004858", "Q21733", "WBGene00000904", "Q21733", "WBGene00000904", "P45897", "WBGene00004858", "Q9TVL3", "WBGene00000410", "P34424", "WBGene00000508", "P34425", "WBGene00000507", "O17869", "WBGene00009650", "P90866", "WBGene00000409", "Q9TYP2", "WBGene00000506" ] }, "reaction_10542172": { "compartment": "compartment_70101", "id": "reaction_10542172", "reactome": "R-CEL-2031355", "name": "WWTR1 binds SMAD2/3:SMAD4 heterotrimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10541983", "species_10511417" ], "products": [ "species_10542170" ], "modifiers": [], "additional_components": [ "WBGene00008748", "Q21733", "WBGene00000904", "P45897", "WBGene00004858", "Q21733", "WBGene00000904", "P45897", "WBGene00004858", "Q19404", "WBGene00008748" ] }, "reaction_10551215": { "compartment": "compartment_13231", "id": "reaction_10551215", "reactome": "R-CEL-5252001", "name": "ATP1B4 binds SNW1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10551211", "species_10505091" ], "products": [ "species_10551213" ], "modifiers": [], "additional_components": [ "Q93235", "WBGene00007646", "Q9XUG9", "WBGene00008074", "Q9XUY5", "WBGene00010117", "WBGene00004806", "Q22836", "WBGene00004806", "Q93235", "WBGene00007646", "Q9XUG9", "WBGene00008074", "Q9XUY5", "WBGene00010117" ] }, "reaction_10543472": { "compartment": "compartment_70101", "id": "reaction_10543472", "reactome": "R-CEL-2187395", "name": "Dephosphorylated SMAD2/3 translocates to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10516318" ], "products": [ "species_10511457" ], "modifiers": [], "additional_components": [ "WBGene00000904", "WBGene00000904" ] }, "reaction_10543410": { "compartment": "compartment_7660", "id": "reaction_10543410", "reactome": "R-CEL-2176491", "name": "NEDD4L binds phosphorylated linker region of SMAD2/3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10543406", "species_10543397" ], "products": [ "species_10543408" ], "modifiers": [], "additional_components": [ "WBGene00022358", "Q21733", "WBGene00000904", "P45897", "WBGene00004858", "Q21733", "WBGene00000904", "P45897", "WBGene00004858", "A0A061ACQ8", "WBGene00022358" ] }, "reaction_10516323": { "compartment": "compartment_7660", "id": "reaction_10516323", "reactome": "R-CEL-209055", "name": "PPM1A dephosphorylates nuclear SMAD2/3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10516316" ], "products": [ "species_113550", "species_10516318", "species_10516314", "species_10511512" ], "modifiers": [ [ "species_10516316", "catalyst" ] ], "additional_components": [ "Q19775", "WBGene00006460", "P45897", "WBGene00004858", "Q21733", "WBGene00000904", "WBGene00000904", "WBGene00006460", "WBGene00004858", "Q19775", "WBGene00006460", "P45897", "WBGene00004858", "Q21733", "WBGene00000904" ] }, "reaction_10543414": { "compartment": "compartment_7660", "id": "reaction_10543414", "reactome": "R-CEL-2176502", "name": "NEDD4L ubiquitinates SMAD2/3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502318", "species_10543408" ], "products": [ "species_10543406", "species_10543412" ], "modifiers": [], "additional_components": [ "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "Q21733", "WBGene00000904", "P45897", "WBGene00004858", "A0A061ACQ8", "WBGene00022358", "WBGene00022358", "Q21733", "WBGene00000904", "P45897", "WBGene00004858", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725" ] }, "reaction_10543416": { "compartment": "compartment_7660", "id": "reaction_10543416", "reactome": "R-CEL-2176503", "name": "Degradation of SMAD2/3:SMAD4 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10543412" ], "products": [], "modifiers": [], "additional_components": [ "Q21733", "WBGene00000904", "P45897", "WBGene00004858", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725" ] }, "reaction_10528057": { "compartment": "compartment_7660", "id": "reaction_10528057", "reactome": "R-CEL-870477", "name": "Ubiquitinated SMAD4 translocates from the nucleus to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10528053" ], "products": [ "species_10528055" ], "modifiers": [], "additional_components": [ "P45897", "WBGene00004858", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "P45897", "WBGene00004858" ] }, "reaction_10511547": { "compartment": "compartment_7660", "id": "reaction_10511547", "reactome": "R-CEL-173545", "name": "Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10511518" ], "products": [], "modifiers": [ [ "species_10511544", "catalyst" ] ], "additional_components": [ "P45897", "WBGene00004858", "Q21733", "WBGene00000904", "P35129", "WBGene00002344", "P91853", "WBGene00006732", "Q17720", "WBGene00006717", "Q20617", "WBGene00006719" ] }, "reaction_10543470": { "compartment": "compartment_7660", "id": "reaction_10543470", "reactome": "R-CEL-2187388", "name": "PPM1A protein phosphatase binds phosphorylated SMAD2/3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10511518", "species_10516314" ], "products": [ "species_10516316" ], "modifiers": [], "additional_components": [ "P45897", "WBGene00004858", "Q21733", "WBGene00000904", "WBGene00006460", "Q19775", "WBGene00006460", "P45897", "WBGene00004858", "Q21733", "WBGene00000904" ] }, "reaction_10548818": { "compartment": "compartment_876", "id": "reaction_10548818", "reactome": "R-CEL-3928654", "name": "Clathrin internalises EPH:EFN complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10548814", "species_10512890", "species_10512936", "species_10548503", "species_10548802" ], "products": [ "species_10548816" ], "modifiers": [], "additional_components": [ "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "WBGene00001130", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "O61460", "WBGene00006868", "P0DM42", "WBGene00000065", "P10984", "WBGene00000064", "P10986", "WBGene00000066", "P0DM41", "WBGene00000063", "species_29358", "P0DM42", "WBGene00000065", "P10984", "WBGene00000064", "P10986", "WBGene00000066", "P0DM41", "WBGene00000063", "species_29358", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "O61460", "WBGene00006868", "P39055", "WBGene00001130", "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "P35603", "WBGene00001082", "Q19123", "WBGene00000157" ] }, "reaction_10549028": { "compartment": "compartment_70101", "id": "reaction_10549028", "reactome": "R-CEL-4093327", "name": "EPHA binds TIAM1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10548777", "species_10516084" ], "products": [ "species_10548779" ], "modifiers": [], "additional_components": [ "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "O61460", "WBGene00006868", "Q9N3S5", "WBGene00021635", "G5EE56", "WBGene00005077", "WBGene00015704", "O01847", "WBGene00015704", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "O61460", "WBGene00006868", "Q9N3S5", "WBGene00021635", "G5EE56", "WBGene00005077" ] }, "reaction_10548616": { "compartment": "compartment_876", "id": "reaction_10548616", "reactome": "R-CEL-3928604", "name": "SFKs phosphorylate VAV2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10548611" ], "products": [ "species_29370", "species_10548613" ], "modifiers": [ [ "species_10548611", "catalyst" ] ], "additional_components": [ "O61460", "WBGene00006868", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "Q9N3S5", "WBGene00021635", "G5EE56", "WBGene00005077", "Q45FX5", "WBGene00006887", "O61460", "WBGene00006868", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "Q9N3S5", "WBGene00021635", "G5EE56", "WBGene00005077", "Q45FX5", "WBGene00006887", "O61460", "WBGene00006868", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "Q9N3S5", "WBGene00021635", "G5EE56", "WBGene00005077", "Q45FX5", "WBGene00006887" ] }, "reaction_10548857": { "compartment": "compartment_876", "id": "reaction_10548857", "reactome": "R-CEL-3928657", "name": "MMP2,9 cleave EPHB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10548503" ], "products": [ "species_10548844", "species_10548491", "species_10548820" ], "modifiers": [ [ "species_10548854", "catalyst" ] ], "additional_components": [ "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "O61460", "WBGene00006868", "WBGene00006868", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "WBGene00006868", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "Q21182", "WBGene00194737" ] }, "reaction_10548842": { "compartment": "compartment_876", "id": "reaction_10548842", "reactome": "R-CEL-3928656", "name": "gamma-secretase cleaves EPHB2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10548820" ], "products": [ "species_10548830", "species_10548840" ], "modifiers": [ [ "species_10532586", "catalyst" ] ], "additional_components": [ "WBGene00006868", "WBGene00006868", "WBGene00006868", "Q23316", "WBGene00000148", "P52166", "WBGene00004769", "Q01608", "WBGene00004958", "O02100", "WBGene00001985", "Q9U357", "WBGene00003975", "O45876", "WBGene00000147" ] }, "reaction_10548618": { "compartment": "compartment_876", "id": "reaction_10548618", "reactome": "R-CEL-3928607", "name": "p-EPHs bind VAV2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10516077", "species_10548609" ], "products": [ "species_10548611" ], "modifiers": [], "additional_components": [ "WBGene00006887", "O61460", "WBGene00006868", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "Q9N3S5", "WBGene00021635", "G5EE56", "WBGene00005077", "O61460", "WBGene00006868", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "Q9N3S5", "WBGene00021635", "G5EE56", "WBGene00005077", "Q45FX5", "WBGene00006887" ] }, "reaction_10548763": { "compartment": "compartment_876", "id": "reaction_10548763", "reactome": "R-CEL-3928628", "name": "VAV exchanges GTP for GDP on RAC1, activating it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10520575", "species_29438" ], "products": [ "species_29420", "species_10509457" ], "modifiers": [ [ "species_10548613", "catalyst" ] ], "additional_components": [ "species_29420", "Q03206", "ced-10", "species_29438", "Q03206", "ced-10", "O61460", "WBGene00006868", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "Q9N3S5", "WBGene00021635", "G5EE56", "WBGene00005077", "Q45FX5", "WBGene00006887" ] }, "reaction_10548782": { "compartment": "compartment_876", "id": "reaction_10548782", "reactome": "R-CEL-3928642", "name": "TIAM1 exchanges GTP for GDP on RAC1, activating it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10520575", "species_29438" ], "products": [ "species_29420", "species_10509457" ], "modifiers": [ [ "species_10548779", "catalyst" ] ], "additional_components": [ "species_29420", "Q03206", "ced-10", "species_29438", "Q03206", "ced-10", "O01847", "WBGene00015704", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "O61460", "WBGene00006868", "Q9N3S5", "WBGene00021635", "G5EE56", "WBGene00005077" ] }, "reaction_10572371": { "compartment": "compartment_161320", "id": "reaction_10572371", "reactome": "R-CEL-9638078", "name": "HEXB cleaves the terminal GalNAc from keratan sulfate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2105012" ], "products": [ "species_2105010", "species_1605658" ], "modifiers": [ [ "species_10536355", "catalyst" ] ], "additional_components": [ "Q22492", "WBGene00020509" ] }, "reaction_10536644": { "compartment": "compartment_161320", "id": "reaction_10536644", "reactome": "R-CEL-1638053", "name": "HEXA cleaves the terminal GalNAc from keratan sulfate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2105012" ], "products": [ "species_2105010", "species_1605658" ], "modifiers": [ [ "species_10536342", "catalyst" ] ], "additional_components": [ "Q22492", "WBGene00020509" ] }, "reaction_10536555": { "compartment": "compartment_161320", "id": "reaction_10536555", "reactome": "R-CEL-1630306", "name": "GLB1 hydrolyses a glycosaminoglycan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2104997" ], "products": [ "species_1605637", "species_2104995" ], "modifiers": [ [ "species_10536350", "catalyst" ] ], "additional_components": [ "WBGene00011832" ] }, "reaction_10542450": { "compartment": "compartment_17963", "id": "reaction_10542450", "reactome": "R-CEL-2076383", "name": "HS3ST1 sulfates GlcN at C3 in heparan sulfate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_741440", "species_10541552" ], "products": [ "species_742343", "species_10541588" ], "modifiers": [ [ "species_10542445", "catalyst" ] ], "additional_components": [ "G5EGU4", "WBGene00001687", "Q18530", "WBGene00003056", "P50605", "WBGene00004749", "P34710", "unc-6", "P34710", "unc-6", "Q18530", "WBGene00003056", "G5EGU4", "WBGene00001687", "P50605", "WBGene00004749", "WBGene00002030" ] }, "reaction_10542484": { "compartment": "compartment_20699", "id": "reaction_10542484", "reactome": "R-CEL-2076611", "name": "HS3STs sulfate GlcN at C3 in heparan sulfate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_741440", "species_10541552" ], "products": [ "species_742343", "species_10541588" ], "modifiers": [ [ "species_10542481", "catalyst" ] ], "additional_components": [ "G5EGU4", "WBGene00001687", "Q18530", "WBGene00003056", "P50605", "WBGene00004749", "P34710", "unc-6", "P34710", "unc-6", "Q18530", "WBGene00003056", "G5EGU4", "WBGene00001687", "P50605", "WBGene00004749", "Q4TTA0", "WBGene00044303", "Q9TZK5", "WBGene00002030" ] }, "reaction_10541429": { "compartment": "compartment_20699", "id": "reaction_10541429", "reactome": "R-CEL-2022860", "name": "NDST1-4 can sulfate a glucosamine residue in heparan to form heparan sulfate (HS)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_741440", "species_10541379" ], "products": [ "species_742343", "species_10541415" ], "modifiers": [ [ "species_10541420", "catalyst" ] ], "additional_components": [ "P34710", "unc-6", "Q18530", "WBGene00003056", "G5EGU4", "WBGene00001687", "P50605", "WBGene00004749", "G5EGU4", "WBGene00001687", "P34710", "unc-6", "Q18530", "WBGene00003056", "P50605", "WBGene00004749", "WBGene00002028" ] }, "reaction_10542470": { "compartment": "compartment_20699", "id": "reaction_10542470", "reactome": "R-CEL-2076508", "name": "HS2ST1 sulfates IdoA at C2 in heparan sulfate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10541516", "species_741440" ], "products": [ "species_742343", "species_10541552" ], "modifiers": [ [ "species_10542467", "catalyst" ] ], "additional_components": [ "G5EGU4", "WBGene00001687", "Q18530", "WBGene00003056", "P50605", "WBGene00004749", "P34710", "unc-6", "G5EGU4", "WBGene00001687", "Q18530", "WBGene00003056", "P50605", "WBGene00004749", "P34710", "unc-6", "WBGene00002029" ] }, "reaction_10541468": { "compartment": "compartment_20699", "id": "reaction_10541468", "reactome": "R-CEL-2022887", "name": "NDST1-4 N-deacetylates GlcNAc residues in heparan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2022884", "species_10541465" ], "products": [ "species_2022890", "species_10541379" ], "modifiers": [ [ "species_10541420", "catalyst" ] ], "additional_components": [ "G5EGU4", "WBGene00001687", "Q18530", "WBGene00003056", "P50605", "WBGene00004749", "P34710", "unc-6", "P34710", "unc-6", "Q18530", "WBGene00003056", "G5EGU4", "WBGene00001687", "P50605", "WBGene00004749", "WBGene00002028" ] }, "reaction_10542462": { "compartment": "compartment_20699", "id": "reaction_10542462", "reactome": "R-CEL-2076419", "name": "HS6STs sulfate GlcN at C6 in heparan sulfate/heparin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_741440", "species_10541624" ], "products": [ "species_742343", "species_10541656" ], "modifiers": [ [ "species_10542455", "catalyst" ] ], "additional_components": [ "P50605", "WBGene00004749", "G5EGU4", "WBGene00001687", "P34710", "unc-6", "Q18530", "WBGene00003056", "G5EGU4", "WBGene00001687", "Q18530", "WBGene00003056", "P50605", "WBGene00004749", "P34710", "unc-6", "WBGene00002031" ] }, "reaction_10541822": { "compartment": "compartment_17963", "id": "reaction_10541822", "reactome": "R-CEL-2024108", "name": "Some HSPGs are secreted to the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10541658" ], "products": [ "species_10541820" ], "modifiers": [], "additional_components": [ "G5EGU4", "WBGene00001687", "Q18530", "WBGene00003056", "P50605", "WBGene00004749", "P34710", "unc-6", "G5EGU4", "WBGene00001687", "Q18530", "WBGene00003056", "P34710", "unc-6", "P50605", "WBGene00004749" ] }, "reaction_10538116": { "compartment": "compartment_20699", "id": "reaction_10538116", "reactome": "R-CEL-1889978", "name": "B3GALT6 transfers Gal to the tetrasaccharide linker", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10538108", "species_735682" ], "products": [ "species_10537964", "species_205687" ], "modifiers": [ [ "species_10538113", "catalyst" ] ], "additional_components": [ "G5EGU4", "WBGene00001687", "Q18530", "WBGene00003056", "P50605", "WBGene00004749", "P34710", "unc-6", "Q8IG72", "WBGene00016751", "G5EGU4", "WBGene00001687", "Q18530", "WBGene00003056", "P50605", "WBGene00004749", "P34710", "unc-6", "Q8IG72", "WBGene00016751", "WBGene00005020" ] }, "reaction_10537925": { "compartment": "compartment_20699", "id": "reaction_10537925", "reactome": "R-CEL-1878002", "name": "XYLTs transfer Xyl to core protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10537876", "species_742361" ], "products": [ "species_10537915", "species_205687" ], "modifiers": [ [ "species_10537920", "catalyst" ] ], "additional_components": [ "Q18530", "WBGene00003056", "G5EGU4", "WBGene00001687", "Q8IG72", "WBGene00016751", "P34710", "unc-6", "P50605", "WBGene00004749", "P50605", "WBGene00004749", "G5EGU4", "WBGene00001687", "P34710", "unc-6", "Q18530", "WBGene00003056", "Q8IG72", "WBGene00016751", "WBGene00005024" ] }, "reaction_10538069": { "compartment": "compartment_20699", "id": "reaction_10538069", "reactome": "R-CEL-1889955", "name": "B3GAT dimers transfer GlcA to tetrasaccharide linker", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1889970", "species_10537964" ], "products": [ "species_205687", "species_10538003" ], "modifiers": [ [ "species_10538066", "catalyst" ] ], "additional_components": [ "G5EGU4", "WBGene00001687", "Q18530", "WBGene00003056", "P50605", "WBGene00004749", "P34710", "unc-6", "Q8IG72", "WBGene00016751", "Q8IG72", "WBGene00016751", "G5EGU4", "WBGene00001687", "Q18530", "WBGene00003056", "P50605", "WBGene00004749", "P34710", "unc-6", "species_266099", "Q09363", "WBGene00005026", "O17708", "WBGene00008293", "Q9XU73", "WBGene00011781", "O17751", "WBGene00008479", "A0A0K3AUF6", "W07G9.2b", "O62113", "WBGene00008160", "O02304", "WBGene00011650" ] }, "reaction_10538124": { "compartment": "compartment_20699", "id": "reaction_10538124", "reactome": "R-CEL-1889981", "name": "B4GALT7 transfers Gal group to xylosyl-unit of the tetrasaccharide linker", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10537915", "species_735682" ], "products": [ "species_10538108", "species_205687" ], "modifiers": [ [ "species_10538121", "catalyst" ] ], "additional_components": [ "P50605", "WBGene00004749", "G5EGU4", "WBGene00001687", "P34710", "unc-6", "Q18530", "WBGene00003056", "Q8IG72", "WBGene00016751", "G5EGU4", "WBGene00001687", "Q18530", "WBGene00003056", "P50605", "WBGene00004749", "P34710", "unc-6", "Q8IG72", "WBGene00016751", "WBGene00005021" ] }, "reaction_10572364": { "compartment": "compartment_20699", "id": "reaction_10572364", "reactome": "R-CEL-9638064", "name": "B3GAT3 dimer transfers GlcA to tetrasaccharide linker", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1889970", "species_10537964" ], "products": [ "species_205687", "species_10538003" ], "modifiers": [ [ "species_10538064", "catalyst" ] ], "additional_components": [ "G5EGU4", "WBGene00001687", "Q18530", "WBGene00003056", "P50605", "WBGene00004749", "P34710", "unc-6", "Q8IG72", "WBGene00016751", "Q8IG72", "WBGene00016751", "G5EGU4", "WBGene00001687", "Q18530", "WBGene00003056", "P50605", "WBGene00004749", "P34710", "unc-6", "species_266099", "Q09363", "WBGene00005026" ] }, "reaction_10537394": { "compartment": "compartment_161320", "id": "reaction_10537394", "reactome": "R-CEL-1678742", "name": "NAGLU hydrolyses Heparan sulfate chain(4)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2090069" ], "products": [ "species_2090080", "species_1678743" ], "modifiers": [ [ "species_10537391", "catalyst" ] ], "additional_components": [ "WBGene00010722" ] }, "reaction_10542691": { "compartment": "compartment_161320", "id": "reaction_10542691", "reactome": "R-CEL-2090038", "name": "NAGLU hydrolyses heparan chain(2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2090053" ], "products": [ "species_1678743", "species_2065212" ], "modifiers": [ [ "species_10537391", "catalyst" ] ], "additional_components": [ "WBGene00010722" ] }, "reaction_10542693": { "compartment": "compartment_161320", "id": "reaction_10542693", "reactome": "R-CEL-2090079", "name": "GLB1 hydrolyses linker chain(2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2090075" ], "products": [ "species_1605637", "species_2090063" ], "modifiers": [ [ "species_10536350", "catalyst" ] ], "additional_components": [ "WBGene00011832" ] }, "reaction_10541480": { "compartment": "compartment_876", "id": "reaction_10541480", "reactome": "R-CEL-2024084", "name": "HS-GAGs translocate to the lysosome for degradation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10537360" ], "products": [ "species_10537017" ], "modifiers": [], "additional_components": [ "G5EGU4", "WBGene00001687", "Q18530", "WBGene00003056", "P34710", "unc-6", "P50605", "WBGene00004749", "P50605", "WBGene00004749", "P34710", "unc-6", "G5EGU4", "WBGene00001687", "Q18530", "WBGene00003056" ] }, "reaction_10537435": { "compartment": "compartment_161320", "id": "reaction_10537435", "reactome": "R-CEL-1678854", "name": "GUSB tetramer hydrolyses CS/HS precursor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2065212" ], "products": [ "species_1678868", "species_2090075" ], "modifiers": [ [ "species_10537432", "catalyst" ], [ "species_427963", "inhibitor" ] ], "additional_components": [ "Q95Q32", "WBGene00013693" ] }, "reaction_10542856": { "compartment": "compartment_876", "id": "reaction_10542856", "reactome": "R-CEL-2142859", "name": "Growing HA is extruded from the cell by ABCC5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2142896" ], "products": [ "species_2160848" ], "modifiers": [ [ "species_10534273", "catalyst" ] ], "additional_components": [ "species_2162224", "species_2162224", "WBGene00003411" ] }, "reaction_10540904": { "compartment": "compartment_17963", "id": "reaction_10540904", "reactome": "R-CEL-2022065", "name": "DSPGs are secreted", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10540902" ], "products": [ "species_10540868" ], "modifiers": [], "additional_components": [ "Q8IG72", "WBGene00016751", "Q8IG72", "WBGene00016751" ] }, "reaction_10537457": { "compartment": "compartment_161320", "id": "reaction_10537457", "reactome": "R-CEL-1793209", "name": "HYAL1 hydrolyses Chondroitin chains", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2065257" ], "products": [ "species_2065212" ], "modifiers": [ [ "species_10537452", "catalyst" ] ], "additional_components": [ "CHEBI:63512", "CHEBI:63513", "CHEBI:63515", "species_2065239", "WBGene00011923" ] }, "reaction_10536470": { "compartment": "compartment_161320", "id": "reaction_10536470", "reactome": "R-CEL-1606789", "name": "ARSB hydrolyses DS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2065231" ], "products": [ "species_1606845", "species_2065213" ], "modifiers": [ [ "species_10536467", "catalyst" ] ], "additional_components": [ "A0A4V0IJ66", "WBGene00006310", "species_74016" ] }, "reaction_10542695": { "compartment": "compartment_161320", "id": "reaction_10542695", "reactome": "R-CEL-2105001", "name": "HEXA cleaves the terminal GalNAc from DS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2065269" ], "products": [ "species_1605658", "species_2105025" ], "modifiers": [ [ "species_10536342", "catalyst" ] ], "additional_components": [ "Q22492", "WBGene00020509" ] }, "reaction_10537447": { "compartment": "compartment_161320", "id": "reaction_10537447", "reactome": "R-CEL-1793207", "name": "ARSB hydrolyses C4S/C6S chains", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2065251", "species_1605715" ], "products": [ "species_2065239", "species_1606845" ], "modifiers": [ [ "species_10536467", "catalyst" ] ], "additional_components": [ "CHEBI:63512", "CHEBI:63513", "A0A4V0IJ66", "WBGene00006310", "species_74016" ] }, "reaction_10540892": { "compartment": "compartment_984", "id": "reaction_10540892", "reactome": "R-CEL-2022056", "name": "DSPG and CSPG translocate to the lysosome for degradation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10540876", "species_10540868" ], "products": [ "species_10540890", "species_10540884" ], "modifiers": [], "additional_components": [ "Q8IG72", "WBGene00016751", "Q8IG72", "WBGene00016751", "Q8IG72", "WBGene00016751", "Q8IG72", "WBGene00016751" ] }, "reaction_10572367": { "compartment": "compartment_161320", "id": "reaction_10572367", "reactome": "R-CEL-9638075", "name": "HEXB cleaves the terminal GalNAc from DS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2065269" ], "products": [ "species_1605658", "species_2105025" ], "modifiers": [ [ "species_10536355", "catalyst" ] ], "additional_components": [ "Q22492", "WBGene00020509" ] }, "reaction_10541472": { "compartment": "compartment_17963", "id": "reaction_10541472", "reactome": "R-CEL-2022911", "name": "CSPG is secreted", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10541470" ], "products": [ "species_10540876" ], "modifiers": [], "additional_components": [ "Q8IG72", "WBGene00016751", "Q8IG72", "WBGene00016751" ] }, "reaction_10572304": { "compartment": "compartment_20699", "id": "reaction_10572304", "reactome": "R-CEL-9632034", "name": "CHSY1 transfers GlcA to chondroitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1889970", "species_10538300" ], "products": [ "species_10538309", "species_205687" ], "modifiers": [ [ "species_10572298", "catalyst" ] ], "additional_components": [ "WBGene00016751", "WBGene00016751", "WBGene00005023" ] }, "reaction_10538324": { "compartment": "compartment_20699", "id": "reaction_10538324", "reactome": "R-CEL-1971487", "name": "CHPF,CHSY3 transfer GalNAc to chondroitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_735700", "species_10538309" ], "products": [ "species_10538303", "species_205687" ], "modifiers": [ [ "species_10538321", "catalyst" ] ], "additional_components": [ "WBGene00016751", "WBGene00016751", "P45895", "WBGene00003253", "Q7Z1Z1", "WBGene00005023" ] }, "reaction_10538329": { "compartment": "compartment_20699", "id": "reaction_10538329", "reactome": "R-CEL-1971491", "name": "CHPF,CHPF2,CHSY3 transfer GlcA to chondroitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1889970", "species_10538300" ], "products": [ "species_10538309", "species_205687" ], "modifiers": [ [ "species_10538321", "catalyst" ] ], "additional_components": [ "WBGene00016751", "WBGene00016751", "P45895", "WBGene00003253", "Q7Z1Z1", "WBGene00005023" ] }, "reaction_10572301": { "compartment": "compartment_20699", "id": "reaction_10572301", "reactome": "R-CEL-9632033", "name": "CHSY1 transfers GalNAc to chondroitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_735700", "species_10538309" ], "products": [ "species_10538303", "species_205687" ], "modifiers": [ [ "species_10572298", "catalyst" ] ], "additional_components": [ "WBGene00016751", "WBGene00016751", "WBGene00005023" ] }, "reaction_10510178": { "compartment": "compartment_5460", "id": "reaction_10510178", "reactome": "R-CEL-163310", "name": "TFAM binds to mitochondrial promoters", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10510174", "species_163305" ], "products": [ "species_10510176" ], "modifiers": [], "additional_components": [ "WBGene00001975", "Q94234", "WBGene00001975" ] }, "reaction_10508532": { "compartment": "compartment_876", "id": "reaction_10508532", "reactome": "R-CEL-109701", "name": "PDPK1 binds PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179838", "species_10508528" ], "products": [ "species_10508530" ], "modifiers": [], "additional_components": [ "WBGene00021022", "Q9UA62", "WBGene00021022", "species_179838" ] }, "reaction_10508551": { "compartment": "compartment_70101", "id": "reaction_10508551", "reactome": "R-CEL-109702", "name": "PDPK1 phosphorylates AKT2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10508521" ], "products": [ "species_29370", "species_10508548" ], "modifiers": [ [ "species_10508530", "catalyst" ] ], "additional_components": [ "Q9XTG7", "WBGene00000103", "G4S4W1", "WBGene00016980", "Q17941", "WBGene00000102", "species_179838", "Q9XTG7", "WBGene00000103", "G4S4W1", "WBGene00016980", "Q17941", "WBGene00000102", "species_179838", "Q9UA62", "WBGene00021022", "species_179838" ] }, "reaction_10508523": { "compartment": "compartment_876", "id": "reaction_10508523", "reactome": "R-CEL-109700", "name": "AKT2 binds PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179838", "species_10508519" ], "products": [ "species_10508521", "species_10508500" ], "modifiers": [], "additional_components": [ "G5EED4", "WBGene00010700", "Q9XTG7", "WBGene00000103", "G4S4W1", "WBGene00016980", "Q17941", "WBGene00000102", "Q9XTG7", "WBGene00000103", "G4S4W1", "WBGene00016980", "Q17941", "WBGene00000102", "species_179838", "WBGene00010700" ] }, "reaction_10510068": { "compartment": "compartment_70101", "id": "reaction_10510068", "reactome": "R-CEL-162425", "name": "p-S295-PDE3B hydrolyses cAMP to AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_30389" ], "products": [ "species_76577" ], "modifiers": [ [ "species_10510065", "catalyst" ] ], "additional_components": [ "WBGene00008443" ] }, "reaction_10508495": { "compartment": "compartment_70101", "id": "reaction_10508495", "reactome": "R-CEL-109699", "name": "PI3K-containing complexes phosphorylate PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10508492", "catalyst" ] ], "additional_components": [ "G5EDP9", "WBGene00000001", "A0A1I6CMA1", "WBGene00020678", "G5EGT9", "WBGene00003007", "P29355", "WBGene00004774", "G5EDJ4", "WBGene00004928" ] }, "reaction_10513499": { "compartment": "compartment_876", "id": "reaction_10513499", "reactome": "R-CEL-194518", "name": "RhoA is activated by nucleotide exchange and inhibits axonal growth", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509486" ], "products": [ "species_10509488" ], "modifiers": [ [ "species_10513496", "catalyst" ] ], "additional_components": [ "Q22038", "WBGene00004357", "species_29420", "Q22038", "WBGene00004357", "species_29438", "WBGene00006496" ] }, "reaction_10522807": { "compartment": "compartment_7660", "id": "reaction_10522807", "reactome": "R-CEL-427514", "name": "eNoSC deacetylates histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10522790", "species_427523" ], "products": [ "species_427497", "species_427498", "species_10517072" ], "modifiers": [ [ "species_10522804", "catalyst" ] ], "additional_components": [ "P62784", "WBGene00001875", "Q10453", "WBGene00001945", "K7ZUH9", "WBGene00001914", "P62784", "WBGene00001875", "K7ZUH9", "WBGene00001914", "Q10453", "WBGene00001945", "Q21921", "WBGene00004800", "O44410", "WBGene00020296", "P62784", "WBGene00001875", "K7ZUH9", "WBGene00001914", "Q10453", "WBGene00001945" ] }, "reaction_10522810": { "compartment": "compartment_7660", "id": "reaction_10522810", "reactome": "R-CEL-427527", "name": "eNoSC dimethylates histone H3 at lysine-9", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10517072" ], "products": [ "species_77502", "species_10507005" ], "modifiers": [ [ "species_10522804", "catalyst" ] ], "additional_components": [ "P62784", "WBGene00001875", "K7ZUH9", "WBGene00001914", "Q10453", "WBGene00001945", "P62784", "WBGene00001875", "K7ZUH9", "WBGene00001914", "Q10453", "WBGene00001945", "Q21921", "WBGene00004800", "O44410", "WBGene00020296", "P62784", "WBGene00001875", "K7ZUH9", "WBGene00001914", "Q10453", "WBGene00001945" ] }, "reaction_10522776": { "compartment": "compartment_7660", "id": "reaction_10522776", "reactome": "R-CEL-427337", "name": "MBD2 binds methylcytosine in chromatin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10522772", "species_10522770" ], "products": [ "species_10522774" ], "modifiers": [], "additional_components": [ "P62784", "WBGene00001875", "K7ZUH9", "WBGene00001914", "Q10453", "WBGene00001945", "WBGene00023409", "G5ECR1", "WBGene00023409", "P62784", "WBGene00001875", "K7ZUH9", "WBGene00001914", "Q10453", "WBGene00001945" ] }, "reaction_10547602": { "compartment": "compartment_70101", "id": "reaction_10547602", "reactome": "R-CEL-3371435", "name": "Constitutive phosphorylation by GSK3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10547597", "species_113592" ], "products": [ "species_29370", "species_10547600" ], "modifiers": [ [ "species_10513574", "catalyst" ] ], "additional_components": [ "WBGene00002004", "WBGene00002004", "Q9U2Q9", "WBGene00001746", "Q09595", "WBGene00010991", "Q93372", "WBGene00010991" ] }, "reaction_10547682": { "compartment": "compartment_7660", "id": "reaction_10547682", "reactome": "R-CEL-3371537", "name": "DBC1 binds SIRT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10547678", "species_10522802" ], "products": [ "species_10547680" ], "modifiers": [], "additional_components": [ "Y37A1B.1a", "WBGene00004800", "Q21921", "WBGene00004800", "A0A0S4XR43", "Y37A1B.1a" ] }, "reaction_10551170": { "compartment": "compartment_7660", "id": "reaction_10551170", "reactome": "R-CEL-5251955", "name": "HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10551131" ], "products": [ "species_113550", "species_10551129", "species_10551155" ], "modifiers": [ [ "species_10551167", "catalyst" ] ], "additional_components": [ "species_29358", "G5EC99", "WBGene00009691", "G5ECU5", "WBGene00009691", "O45246", "WBGene00002026", "K8ERU5", "WBGene00018328", "WBGene00018328", "G5EC99", "WBGene00009691", "G5ECU5", "WBGene00009691", "O45246", "WBGene00002026", "species_113582", "Q9TY07", "WBGene00001042", "Q94216", "WBGene00001029" ] }, "reaction_10551203": { "compartment": "compartment_70101", "id": "reaction_10551203", "reactome": "R-CEL-5251959", "name": "HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10551073" ], "products": [ "species_29372", "species_10551194" ], "modifiers": [ [ "species_10551200", "catalyst" ] ], "additional_components": [ "G5ECU5", "WBGene00009691", "O45246", "WBGene00002026", "G5EC99", "WBGene00009691", "species_29358", "G5ECU5", "WBGene00009691", "O45246", "WBGene00002026", "G5EC99", "WBGene00009691", "species_113582", "Q9TY07", "WBGene00001042", "Q94216", "WBGene00001029" ] }, "reaction_10551077": { "compartment": "compartment_70101", "id": "reaction_10551077", "reactome": "R-CEL-5251942", "name": "Hikeshi binds HSP70s:ATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10551014", "species_10551073" ], "products": [ "species_10551075" ], "modifiers": [], "additional_components": [ "WBGene00018328", "G5ECU5", "WBGene00009691", "O45246", "WBGene00002026", "G5EC99", "WBGene00009691", "species_29358", "G5ECU5", "WBGene00009691", "O45246", "WBGene00002026", "G5EC99", "WBGene00009691", "species_29358", "K8ERU5", "WBGene00018328" ] }, "reaction_10549720": { "compartment": "compartment_70101", "id": "reaction_10549720", "reactome": "R-CEL-4793911", "name": "MAPKAPK2 phosphorylates HSF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10547597", "species_113592" ], "products": [ "species_29370", "species_10549717" ], "modifiers": [ [ "species_10512624", "catalyst" ] ], "additional_components": [ "WBGene00002004", "WBGene00002004", "Q21360", "WBGene00010681", "Q965G5", "WBGene00007007" ] }, "reaction_10551241": { "compartment": "compartment_70101", "id": "reaction_10551241", "reactome": "R-CEL-5252079", "name": "HSP110s exchange ATP for ADP on HSP70s:ADP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10551194", "species_113592" ], "products": [ "species_29370", "species_10551073" ], "modifiers": [ [ "species_10551231", "catalyst" ], [ "species_10551239", "inhibitor" ] ], "additional_components": [ "G5ECU5", "WBGene00009691", "O45246", "WBGene00002026", "G5EC99", "WBGene00009691", "species_113582", "G5ECU5", "WBGene00009691", "O45246", "WBGene00002026", "G5EC99", "WBGene00009691", "species_29358", "Q05036", "WBGene00016250", "O44739", "WBGene00000236", "O61980", "WBGene00006760", "G5EE04", "WBGene00011735" ] }, "reaction_10547675": { "compartment": "compartment_70101", "id": "reaction_10547675", "reactome": "R-CEL-3371531", "name": "Constitutive phosphorylation by pERK1/2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10547597", "species_113592" ], "products": [ "species_29370", "species_10547673" ], "modifiers": [ [ "species_10542082", "catalyst" ] ], "additional_components": [ "WBGene00002004", "WBGene00002004", "P39745", "WBGene00003401" ] }, "reaction_10547692": { "compartment": "compartment_7660", "id": "reaction_10547692", "reactome": "R-CEL-3371567", "name": "DBC1 is phosphorylated by ATM/ART", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10547684" ], "products": [ "species_113582", "species_10547678" ], "modifiers": [ [ "species_10547689", "catalyst" ] ], "additional_components": [ "Y37A1B.1a", "Y37A1B.1a", "WBGene00000226" ] }, "reaction_10549888": { "compartment": "compartment_7660", "id": "reaction_10549888", "reactome": "R-CEL-5082409", "name": "Dissociation of HSF1:HSP90 complex in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10549886" ], "products": [ "species_10549884", "species_10549878", "species_10549859" ], "modifiers": [], "additional_components": [ "G5EFT5", "WBGene00002004", "Q23280", "WBGene00022599", "Q18688", "WBGene00000915", "Q18688", "WBGene00000915", "WBGene00022599", "WBGene00002004" ] }, "reaction_10547717": { "compartment": "compartment_70101", "id": "reaction_10547717", "reactome": "R-CEL-3371591", "name": "Trimerization of cytosolic HSF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10547597" ], "products": [ "species_10547664" ], "modifiers": [ [ "species_10509904", "catalyst" ] ], "additional_components": [ "WBGene00002004", "G5EFT5", "WBGene00002004", "WBGene00001168" ] }, "reaction_10549861": { "compartment": "compartment_7660", "id": "reaction_10549861", "reactome": "R-CEL-5082391", "name": "Trimerization of HSF1 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10549859" ], "products": [ "species_10547668" ], "modifiers": [], "additional_components": [ "WBGene00002004", "G5EFT5", "WBGene00002004" ] }, "reaction_10547670": { "compartment": "compartment_70101", "id": "reaction_10547670", "reactome": "R-CEL-3371527", "name": "HSF1 trimer translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10547664" ], "products": [ "species_10547668" ], "modifiers": [], "additional_components": [ "G5EFT5", "WBGene00002004", "G5EFT5", "WBGene00002004" ] }, "reaction_10551291": { "compartment": "compartment_70101", "id": "reaction_10551291", "reactome": "R-CEL-5324632", "name": "Dissociation of cytosolic HSF1:HSP90:HDAC6:PTGES3 upon sensing protein aggregates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5324631", "species_10551286" ], "products": [ "species_10547597", "species_10517708", "species_10551288", "species_10547652" ], "modifiers": [ [ "species_10551286", "catalyst" ] ], "additional_components": [ "Q18688", "WBGene00000915", "P54812", "WBGene00008053", "Q23280", "WBGene00022599", "G5EFT5", "WBGene00002004", "Q20296", "WBGene00018319", "WBGene00002004", "WBGene00022599", "P54812", "WBGene00008053", "Q20296", "WBGene00018319", "Q18688", "WBGene00000915", "Q18688", "WBGene00000915", "P54812", "WBGene00008053", "Q23280", "WBGene00022599", "G5EFT5", "WBGene00002004", "Q20296", "WBGene00018319" ] }, "reaction_10547709": { "compartment": "compartment_70101", "id": "reaction_10547709", "reactome": "R-CEL-3371586", "name": "Dissociation of cytosolic HSF1:HSP90 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10547707" ], "products": [ "species_10547597", "species_10517708", "species_10547652" ], "modifiers": [], "additional_components": [ "Q18688", "WBGene00000915", "Q23280", "WBGene00022599", "G5EFT5", "WBGene00002004", "WBGene00002004", "WBGene00022599", "Q18688", "WBGene00000915" ] }, "reaction_10549857": { "compartment": "compartment_7660", "id": "reaction_10549857", "reactome": "R-CEL-5082387", "name": "Phosphorylation of HSF1 at Ser230 induces transactivation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10547668" ], "products": [ "species_113582", "species_10549835" ], "modifiers": [ [ "species_10549854", "catalyst" ] ], "additional_components": [ "G5EFT5", "WBGene00002004", "G5EFT5", "WBGene00002004", "O62305", "WBGene00006779" ] }, "reaction_10549842": { "compartment": "compartment_7660", "id": "reaction_10549842", "reactome": "R-CEL-5082356", "name": "HSF1-mediated gene expression", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10549772" ], "products": [ "species_10549830" ], "modifiers": [ [ "species_10549840", "catalyst" ], [ "species_10549835", "catalyst" ] ], "additional_components": [ "G5EFT5", "WBGene00002004", "Q9U3B7", "WBGene00002002", "Q20660", "WBGene00002021", "Q19227", "WBGene00014233", "P06581", "WBGene00002018", "B0M0L8", "WBGene00002024", "Q19228", "WBGene00014233", "P06582", "WBGene00002016", "G5EF99", "WBGene00014233", "Q20363", "WBGene00004798", "P34696", "WBGene00002015", "P02513", "WBGene00002019", "P09446", "WBGene00002005", "G5EC99", "WBGene00009691", "G5ECU5", "WBGene00009691", "O45246", "WBGene00002026", "Q18688", "WBGene00000915", "G5EFT5", "WBGene00002004", "G5EFT5", "WBGene00002004" ] }, "reaction_10549876": { "compartment": "compartment_7660", "id": "reaction_10549876", "reactome": "R-CEL-5082405", "name": "Phosphorylation of HSF1 at Ser326 induces transactivation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10547668" ], "products": [ "species_113582", "species_10549840" ], "modifiers": [ [ "species_10549873", "catalyst" ] ], "additional_components": [ "G5EFT5", "WBGene00002004", "G5EFT5", "WBGene00002004", "P91040", "WBGene00015697", "Q95Q95", "WBGene00002583", "Q68TI8", "WBGene00000911" ] }, "reaction_10547705": { "compartment": "compartment_7660", "id": "reaction_10547705", "reactome": "R-CEL-3371582", "name": "HSBP1 binds HSF1 trimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10547701", "species_10547668" ], "products": [ "species_10547703" ], "modifiers": [], "additional_components": [ "Q9U3B7", "WBGene00002002", "G5EFT5", "WBGene00002004", "G5EFT5", "WBGene00002004", "Q9U3B7", "WBGene00002002" ] }, "reaction_10551274": { "compartment": "compartment_7660", "id": "reaction_10551274", "reactome": "R-CEL-5324617", "name": "HSP90:FKBP4:PTGES3 binds HSF1 trimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10551270", "species_10547668" ], "products": [ "species_10551272" ], "modifiers": [], "additional_components": [ "O45418", "WBGene00001431", "Q23280", "WBGene00022599", "Q18688", "WBGene00000915", "G5EFT5", "WBGene00002004", "O45418", "WBGene00001431", "G5EFT5", "WBGene00002004", "Q23280", "WBGene00022599", "Q18688", "WBGene00000915" ] }, "reaction_10535090": { "compartment": "compartment_70616", "id": "reaction_10535090", "reactome": "R-CEL-1483165", "name": "PA is converted to CDP-DAG by CDS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524101", "species_110577" ], "products": [ "species_159450", "species_1524064" ], "modifiers": [ [ "species_10535087", "catalyst" ] ], "additional_components": [ "WBGene00016384" ] }, "reaction_10535537": { "compartment": "compartment_984", "id": "reaction_10535537", "reactome": "R-CEL-1566981", "name": "Fibronectin degradation by MMP1, 3, 7, 12, 13, 19, CTSS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10517394" ], "products": [ "species_10535515" ], "modifiers": [ [ "species_10535534", "catalyst" ] ], "additional_components": [ "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "Q21182", "WBGene00194737", "O45734", "WBGene00000776", "Q23030", "WBGene00019986", "Q93512", "WBGene00019986" ] }, "reaction_10536417": { "compartment": "compartment_17963", "id": "reaction_10536417", "reactome": "R-CEL-1605825", "name": "MT-MMPs are sorted to the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10536012" ], "products": [ "species_10536415" ], "modifiers": [], "additional_components": [ "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "Q21182", "WBGene00194737", "A0A0K3ARD1", "WBGene00194737", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "Q21182", "WBGene00194737" ] }, "reaction_10536167": { "compartment": "compartment_984", "id": "reaction_10536167", "reactome": "R-CEL-1604731", "name": "Autocatalytic activation of MMP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10535663" ], "products": [ "species_10536164", "species_10534164" ], "modifiers": [ [ "species_10535663", "catalyst" ] ], "additional_components": [ "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "Q21182", "WBGene00194737", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "Q21182", "WBGene00194737", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "Q21182", "WBGene00194737" ] }, "reaction_10536136": { "compartment": "compartment_984", "id": "reaction_10536136", "reactome": "R-CEL-1604690", "name": "Activation of MMP9 intermediate form by MMPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10535755" ], "products": [ "species_10536134", "species_10534192" ], "modifiers": [ [ "species_10535771", "catalyst" ] ], "additional_components": [ "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "Q21182", "WBGene00194737", "A0A0K3ARD1", "WBGene00194737", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "Q21182", "WBGene00194737", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "G5EBU3", "WBGene00016283", "Q21182", "WBGene00194737", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "A0A0K3ARD1", "WBGene00194737" ] }, "reaction_10535593": { "compartment": "compartment_984", "id": "reaction_10535593", "reactome": "R-CEL-1592297", "name": "Full activation of MMP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10535588" ], "products": [ "species_10534120" ], "modifiers": [ [ "species_10535590", "catalyst" ] ], "additional_components": [ "O62390", "WBGene00194737", "Q21182", "WBGene00194737", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "G5EBU3", "WBGene00016283", "Q21182", "WBGene00194737", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737" ] }, "reaction_10536014": { "compartment": "compartment_17963", "id": "reaction_10536014", "reactome": "R-CEL-1602466", "name": "Activation of MT-MMPs by FURIN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10535950" ], "products": [ "species_10536012" ], "modifiers": [ [ "species_10510315", "catalyst" ] ], "additional_components": [ "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "Q21182", "WBGene00194737", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "Q21182", "WBGene00194737", "A0A0K3ARD1", "WBGene00194737", "WBGene00002232" ] }, "reaction_10536047": { "compartment": "compartment_17963", "id": "reaction_10536047", "reactome": "R-CEL-1602484", "name": "Activation of proMMP11 by FURIN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10536045" ], "products": [ "species_10534227" ], "modifiers": [ [ "species_10510315", "catalyst" ] ], "additional_components": [ "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "Q21182", "WBGene00194737", "Q21182", "WBGene00194737", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "WBGene00002232" ] }, "reaction_10536244": { "compartment": "compartment_984", "id": "reaction_10536244", "reactome": "R-CEL-1604732", "name": "Autocatalytic activation of proMMP13", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10536197" ], "products": [ "species_10534136", "species_10536241" ], "modifiers": [ [ "species_10536197", "catalyst" ], [ "species_10535571", "inhibitor" ] ], "additional_components": [ "Q21182", "WBGene00194737", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "Q21182", "WBGene00194737", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "Q21182", "WBGene00194737", "Q21182", "WBGene00194737", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "WBGene00000702" ] }, "reaction_10535573": { "compartment": "compartment_984", "id": "reaction_10535573", "reactome": "R-CEL-1592278", "name": "Autocatalytic activation of proMMP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10535551" ], "products": [ "species_10535565", "species_10534150" ], "modifiers": [ [ "species_10535551", "catalyst" ], [ "species_10535571", "inhibitor" ] ], "additional_components": [ "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "Q21182", "WBGene00194737", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "Q21182", "WBGene00194737", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "Q21182", "WBGene00194737", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "Q21182", "WBGene00194737", "WBGene00000702" ] }, "reaction_10536277": { "compartment": "compartment_984", "id": "reaction_10536277", "reactome": "R-CEL-1604741", "name": "Initial activation of proMMP13 by MMP14 (MT1-MMP)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10536061" ], "products": [ "species_10536181", "species_10536258" ], "modifiers": [ [ "species_10536274", "catalyst" ] ], "additional_components": [ "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "Q21182", "WBGene00194737", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "Q21182", "WBGene00194737", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "Q21182", "WBGene00194737", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283" ] }, "reaction_10536120": { "compartment": "compartment_984", "id": "reaction_10536120", "reactome": "R-CEL-1604359", "name": "Initial activation of proMMP2 by MMP1, 7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10536103" ], "products": [ "species_10535551", "species_10536117" ], "modifiers": [ [ "species_10534120", "catalyst" ] ], "additional_components": [ "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "Q21182", "WBGene00194737", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "Q21182", "WBGene00194737", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "G5EBU3", "WBGene00016283", "Q21182", "WBGene00194737", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "A0A0K3ARD1", "WBGene00194737" ] }, "reaction_10536312": { "compartment": "compartment_984", "id": "reaction_10536312", "reactome": "R-CEL-1604752", "name": "Initial activation of proMMP13 by MMP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10536061" ], "products": [ "species_10536291", "species_10536195" ], "modifiers": [ [ "species_10536309", "catalyst" ] ], "additional_components": [ "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "Q21182", "WBGene00194737", "Q21182", "WBGene00194737", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "Q21182", "WBGene00194737", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "Q93512", "WBGene00019986", "O45734", "WBGene00000776", "Q23030", "WBGene00019986", "O62390", "WBGene00194737", "Q21182", "WBGene00194737", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987" ] }, "reaction_10535774": { "compartment": "compartment_984", "id": "reaction_10535774", "reactome": "R-CEL-1592436", "name": "Initial activation of proMMP9 by MMPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10535741" ], "products": [ "species_10535755", "species_10535769" ], "modifiers": [ [ "species_10535771", "catalyst" ] ], "additional_components": [ "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "Q21182", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "Q21182", "WBGene00194737", "A0A0K3ARD1", "WBGene00194737", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "Q21182", "WBGene00194737", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "O62390", "WBGene00194737", "G5EBU3", "WBGene00016283", "Q21182", "WBGene00194737", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "A0A0K3ARD1", "WBGene00194737" ] }, "reaction_10536031": { "compartment": "compartment_984", "id": "reaction_10536031", "reactome": "R-CEL-1602473", "name": "Autocatalytic activation of MMP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10535621" ], "products": [ "species_10536028", "species_10535588" ], "modifiers": [ [ "species_10535621", "catalyst" ] ], "additional_components": [ "O62390", "WBGene00194737", "Q21182", "WBGene00194737", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "Q21182", "WBGene00194737", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "Q21182", "WBGene00194737", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987" ] }, "reaction_10534261": { "compartment": "compartment_984", "id": "reaction_10534261", "reactome": "R-CEL-1454781", "name": "MMP1,3,13 (2, 7-12, 19) binding by Alpha-2 macroglubulin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10534199", "species_10534257" ], "products": [ "species_10534259" ], "modifiers": [], "additional_components": [ "K8F7Z5", "WBGene00008735", "Q7YTU0", "WBGene00013969", "O62390", "WBGene00194737", "Q21182", "WBGene00194737", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "Q21182", "WBGene00194737", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "K8F7Z5", "WBGene00008735", "Q7YTU0", "WBGene00013969" ] }, "reaction_10568695": { "compartment": "compartment_984", "id": "reaction_10568695", "reactome": "R-CEL-8942302", "name": "MMP13 cleaves OPTC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10568612" ], "products": [ "species_10568618", "species_10568692" ], "modifiers": [ [ "species_10534136", "catalyst" ] ], "additional_components": [ "WBGene00019351", "WBGene00019351", "WBGene00019351", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "Q21182", "WBGene00194737", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283" ] }, "reaction_10544776": { "compartment": "compartment_876", "id": "reaction_10544776", "reactome": "R-CEL-2533950", "name": "Fibronectin degradation by MMP14, TMPRSS6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10517394" ], "products": [ "species_10535515" ], "modifiers": [ [ "species_10534376", "catalyst" ] ], "additional_components": [ "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "Q21182", "WBGene00194737", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283" ] }, "reaction_10548232": { "compartment": "compartment_876", "id": "reaction_10548232", "reactome": "R-CEL-3788061", "name": "Fibronectin degradation by ADAM8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10517394" ], "products": [ "species_10548207" ], "modifiers": [ [ "species_10548229", "catalyst" ] ], "additional_components": [ "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769", "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q19844", "WBGene00270320", "A0A1D3PCM0", "WBGene00270320", "G5EDW5", "WBGene00000074", "G5EFD5", "WBGene00006804" ] }, "reaction_10535392": { "compartment": "compartment_984", "id": "reaction_10535392", "reactome": "R-CEL-1564164", "name": "Collagen type V degradation by MMP2,9,10", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10519175" ], "products": [ "species_10535387" ], "modifiers": [ [ "species_10535389", "catalyst" ] ], "additional_components": [ "O76368", "WBGene00000674", "Q09457", "WBGene00000251", "Q9N4U2", "WBGene00000647", "P17140", "WBGene00002280", "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689", "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689", "O76368", "WBGene00000674", "Q09457", "WBGene00000251", "Q9N4U2", "WBGene00000647", "P17140", "WBGene00002280", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "Q21182", "WBGene00194737" ] }, "reaction_10543302": { "compartment": "compartment_984", "id": "reaction_10543302", "reactome": "R-CEL-2168923", "name": "Collagen type XVIII endostatin release", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10543225" ], "products": [ "species_10543255", "species_10543253" ], "modifiers": [ [ "species_10543299", "catalyst" ] ], "additional_components": [ "Q19368", "WBGene00000702", "WBGene00000702", "Q19368", "WBGene00000702", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "Q21182", "WBGene00194737", "P43510", "WBGene00000786", "O45734", "WBGene00000776", "Q23030", "WBGene00019986", "Q93512", "WBGene00019986" ] }, "reaction_10535495": { "compartment": "compartment_984", "id": "reaction_10535495", "reactome": "R-CEL-1564169", "name": "Collagen type VIII degradation by MMP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10535492" ], "products": [ "species_10533894" ], "modifiers": [ [ "species_10534120", "catalyst" ] ], "additional_components": [ "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689", "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689", "O62390", "WBGene00194737", "G5EBU3", "WBGene00016283", "Q21182", "WBGene00194737", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "A0A0K3ARD1", "WBGene00194737" ] }, "reaction_10544552": { "compartment": "compartment_984", "id": "reaction_10544552", "reactome": "R-CEL-2471621", "name": "Endostatin degradation by cathepsins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10543255" ], "products": [], "modifiers": [ [ "species_10544549", "catalyst" ] ], "additional_components": [ "WBGene00000702", "P43510", "WBGene00000786", "O45734", "WBGene00000776", "Q23030", "WBGene00019986", "Q93512", "WBGene00019986", "Q21966", "WBGene00000217" ] }, "reaction_10557611": { "compartment": "compartment_5460", "id": "reaction_10557611", "reactome": "R-CEL-5696408", "name": "PXLP-K278-PHYKPL tetramer hydrolyses 5PHL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5696409", "species_113521" ], "products": [ "species_113548", "species_5693978", "species_113556" ], "modifiers": [ [ "species_10557608", "catalyst" ] ], "additional_components": [ "P91408", "WBGene00020139" ] }, "reaction_10534379": { "compartment": "compartment_984", "id": "reaction_10534379", "reactome": "R-CEL-1474210", "name": "Collagen type III degradation by MMP14", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10518945" ], "products": [ "species_10533696" ], "modifiers": [ [ "species_10534376", "catalyst" ] ], "additional_components": [ "Q9N4U2", "WBGene00000647", "O76368", "WBGene00000674", "Q09457", "WBGene00000251", "Q9N4U2", "WBGene00000647", "O76368", "WBGene00000674", "Q09457", "WBGene00000251", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "Q21182", "WBGene00194737", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283" ] }, "reaction_10534384": { "compartment": "compartment_984", "id": "reaction_10534384", "reactome": "R-CEL-1474213", "name": "Collagen type III degradation by MMP1,8,9,13", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10518945" ], "products": [ "species_10533696" ], "modifiers": [ [ "species_10534381", "catalyst" ] ], "additional_components": [ "Q9N4U2", "WBGene00000647", "O76368", "WBGene00000674", "Q09457", "WBGene00000251", "Q9N4U2", "WBGene00000647", "O76368", "WBGene00000674", "Q09457", "WBGene00000251", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "Q21182", "WBGene00194737" ] }, "reaction_10543312": { "compartment": "compartment_984", "id": "reaction_10543312", "reactome": "R-CEL-2172433", "name": "Collagen type XIX degradation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10542657" ], "products": [], "modifiers": [], "additional_components": [ "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689" ] }, "reaction_10544561": { "compartment": "compartment_984", "id": "reaction_10544561", "reactome": "R-CEL-2473584", "name": "Collagen type III degradation by MMP15", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10518945" ], "products": [ "species_10533696" ], "modifiers": [ [ "species_10536395", "catalyst" ] ], "additional_components": [ "Q9N4U2", "WBGene00000647", "O76368", "WBGene00000674", "Q09457", "WBGene00000251", "Q9N4U2", "WBGene00000647", "O76368", "WBGene00000674", "Q09457", "WBGene00000251", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "Q21182", "WBGene00194737", "A0A0K3ARD1", "WBGene00194737" ] }, "reaction_10544563": { "compartment": "compartment_876", "id": "reaction_10544563", "reactome": "R-CEL-2473594", "name": "Collagen type II degradation by MMP15", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10517286" ], "products": [ "species_10533498" ], "modifiers": [ [ "species_10536395", "catalyst" ] ], "additional_components": [ "O76368", "WBGene00000674", "Q09457", "WBGene00000251", "Q9N4U2", "WBGene00000647", "Q09457", "WBGene00000251", "Q9N4U2", "WBGene00000647", "O76368", "WBGene00000674", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "Q21182", "WBGene00194737", "A0A0K3ARD1", "WBGene00194737" ] }, "reaction_10544565": { "compartment": "compartment_876", "id": "reaction_10544565", "reactome": "R-CEL-2473596", "name": "Collagen type I degradation by MMP15", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509625" ], "products": [ "species_10533300" ], "modifiers": [ [ "species_10536395", "catalyst" ] ], "additional_components": [ "Q9N4U2", "WBGene00000647", "Q9N4U2", "WBGene00000647", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "Q21182", "WBGene00194737", "A0A0K3ARD1", "WBGene00194737" ] }, "reaction_10534197": { "compartment": "compartment_984", "id": "reaction_10534197", "reactome": "R-CEL-1454757", "name": "Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10534088" ], "products": [], "modifiers": [ [ "species_10534194", "catalyst" ] ], "additional_components": [ "Q9N4U2", "WBGene00000647", "O76368", "WBGene00000674", "Q09457", "WBGene00000251", "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "Q21182", "WBGene00194737" ] }, "reaction_10534266": { "compartment": "compartment_984", "id": "reaction_10534266", "reactome": "R-CEL-1454822", "name": "Collagen type I degradation by MMP1,2,8,13, PRSS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509625" ], "products": [ "species_10533300" ], "modifiers": [ [ "species_10534263", "catalyst" ] ], "additional_components": [ "Q9N4U2", "WBGene00000647", "Q9N4U2", "WBGene00000647", "Q21182", "WBGene00194737", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737" ] }, "reaction_10534362": { "compartment": "compartment_984", "id": "reaction_10534362", "reactome": "R-CEL-1474197", "name": "Collagen type II degradation by MMP1,3,8,13,PRSS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10517286" ], "products": [ "species_10533498" ], "modifiers": [ [ "species_10534359", "catalyst" ] ], "additional_components": [ "O76368", "WBGene00000674", "Q09457", "WBGene00000251", "Q9N4U2", "WBGene00000647", "Q09457", "WBGene00000251", "Q9N4U2", "WBGene00000647", "O76368", "WBGene00000674", "Q21182", "WBGene00194737", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737" ] }, "reaction_10543197": { "compartment": "compartment_876", "id": "reaction_10543197", "reactome": "R-CEL-2167942", "name": "Collagen type XIII ectodomain shedding", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10542932" ], "products": [ "species_10543195", "species_10543121" ], "modifiers": [], "additional_components": [ "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689", "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689", "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689" ] }, "reaction_10548284": { "compartment": "compartment_876", "id": "reaction_10548284", "reactome": "R-CEL-3791155", "name": "Laminin-322 degradation by MMP14", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10517354" ], "products": [ "species_10548282" ], "modifiers": [ [ "species_10534376", "catalyst" ] ], "additional_components": [ "O44565", "WBGene00002247", "Q18823", "WBGene00016913", "Q19981", "WBGene00006432", "G5EG68", "WBGene00018304", "Q06561", "WBGene00006787", "G5ECE3", "WBGene00002248", "Q21313", "WBGene00001328", "G5ECE3", "WBGene00002248", "Q21313", "WBGene00001328", "O44565", "WBGene00002247", "G5EG68", "WBGene00018304", "Q06561", "WBGene00006787", "Q18823", "WBGene00016913", "Q19981", "WBGene00006432", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "Q21182", "WBGene00194737", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283" ] }, "reaction_10568621": { "compartment": "compartment_984", "id": "reaction_10568621", "reactome": "R-CEL-8940554", "name": "MMP2 cleaves OPTC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10568612" ], "products": [ "species_10568618", "species_10568616", "species_10568614" ], "modifiers": [ [ "species_10534150", "catalyst" ] ], "additional_components": [ "WBGene00019351", "WBGene00019351", "WBGene00019351", "WBGene00019351", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "Q21182", "WBGene00194737", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646" ] }, "reaction_10511937": { "compartment": "compartment_7660", "id": "reaction_10511937", "reactome": "R-CEL-176318", "name": "Loading of claspin onto DNA during replication origin firing", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502234", "species_10511927" ], "products": [ "species_10511929" ], "modifiers": [], "additional_components": [ "Q7JMR0", "WBGene00009372", "O01493", "WBGene00016421", "Q9XX16", "WBGene00012651", "Q23249", "WBGene00013857", "Q9XX17", "WBGene00012650", "Q21037", "WBGene00003882", "P91155", "WBGene00000382", "O16297", "WBGene00003159", "Q95XQ8", "WBGene00003156", "Q9XXI9", "WBGene00003154", "Q21902", "WBGene00003157", "P34647", "WBGene00003158", "Q9XVR7", "WBGene00003155", "Q9U2C2", "WBGene00012935", "O61847", "WBGene00019362", "WBGene00009127", "O17838", "WBGene00009127", "Q7JMR0", "WBGene00009372", "O01493", "WBGene00016421", "Q9XX16", "WBGene00012651", "Q23249", "WBGene00013857", "Q9XX17", "WBGene00012650", "Q21037", "WBGene00003882", "P91155", "WBGene00000382", "O16297", "WBGene00003159", "Q95XQ8", "WBGene00003156", "Q9XXI9", "WBGene00003154", "Q21902", "WBGene00003157", "P34647", "WBGene00003158", "Q9XVR7", "WBGene00003155", "Q9U2C2", "WBGene00012935", "O61847", "WBGene00019362" ] }, "reaction_10511922": { "compartment": "compartment_7660", "id": "reaction_10511922", "reactome": "R-CEL-176264", "name": "Recruitment of the Rad9-Hus1-Rad1 complex to DNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10511917", "species_10511913" ], "products": [ "species_10511919" ], "modifiers": [ [ "species_10511917", "catalyst" ] ], "additional_components": [ "P53016", "WBGene00004340", "G5EGG2", "WBGene00001998", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "Q95Y97", "WBGene00019767", "G5EFI9", "WBGene00002042", "G5EC44", "WBGene00003417", "Q95Q27", "WBGene00001997", "G5EFI9", "WBGene00002042", "G5EC44", "WBGene00003417", "Q95Q27", "WBGene00001997", "P53016", "WBGene00004340", "G5EGG2", "WBGene00001998", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "Q95Y97", "WBGene00019767", "P53016", "WBGene00004340", "G5EGG2", "WBGene00001998", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "Q95Y97", "WBGene00019767" ] }, "reaction_10502791": { "compartment": "compartment_7660", "id": "reaction_10502791", "reactome": "R-CEL-69604", "name": "Phosphorylation of Cdc25A at Ser-123 by Chk1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10502759" ], "products": [ "species_113582", "species_10502781" ], "modifiers": [ [ "species_10502788", "catalyst" ] ], "additional_components": [ "WBGene00000389", "WBGene00000389", "WBGene00000498" ] }, "reaction_10507017": { "compartment": "compartment_7660", "id": "reaction_10507017", "reactome": "R-CEL-75010", "name": "Phosphorylation of Cdc25C at Ser 216 by Chk1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10507012" ], "products": [ "species_113582", "species_10507015" ], "modifiers": [ [ "species_10502788", "catalyst" ] ], "additional_components": [ "WBGene00000389", "WBGene00000389", "WBGene00000498" ] }, "reaction_10542996": { "compartment": "compartment_12045", "id": "reaction_10542996", "reactome": "R-CEL-2161890", "name": "Arachidonic acid is epoxidated to 5,6-EET by CYP(4)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29368", "species_29768", "species_29364" ], "products": [ "species_29356", "species_29366", "species_2142739" ], "modifiers": [ [ "species_10507902", "catalyst" ] ], "additional_components": [ "O45659", "WBGene00010589", "O61204", "WBGene00015045", "O61935", "WBGene00020386", "O62377", "WBGene00011699", "O62378", "WBGene00011698", "P90771", "WBGene00007913", "Q20315", "WBGene00018333", "A0A0M7RF98", "WBGene00018264", "Q27465", "WBGene00015135", "G5ECD0", "WBGene00007362", "Q27470", "WBGene00015709", "G5EE22", "WBGene00012448", "Q27471", "WBGene00016092", "H2KY69", "WBGene00015044", "Q27482", "WBGene00016768", "H2KYS3", "WBGene00000905", "Q27499", "WBGene00018334", "O02627", "WBGene00015399", "Q965T7", "WBGene00021710", "O02628", "WBGene00015400", "Q9N4Q4", "WBGene00021168", "O02641", "WBGene00019967", "Q9N5I1", "WBGene00019565", "O16220", "WBGene00016786", "O16362", "WBGene00018413", "O16482", "WBGene00016860", "O16670", "WBGene00018262", "O16671", "WBGene00018261", "O16673", "WBGene00018260", "O44649", "WBGene00019473", "O44650", "WBGene00019472", "O44651", "WBGene00019471", "O44652", "WBGene00019470", "O44655", "WBGene00015040", "O44656", "WBGene00015041", "O44657", "WBGene00015042", "O44658", "WBGene00015043", "O44704", "WBGene00016686", "O44706", "WBGene00016697", "O45364", "WBGene00008829" ] }, "reaction_10542998": { "compartment": "compartment_12045", "id": "reaction_10542998", "reactome": "R-CEL-2161899", "name": "Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29368", "species_29768", "species_29364" ], "products": [ "species_29356", "species_2161753", "species_29366" ], "modifiers": [ [ "species_10507902", "catalyst" ] ], "additional_components": [ "CHEBI:34130", "CHEBI:34490", "CHEBI:34157", "O45659", "WBGene00010589", "O61204", "WBGene00015045", "O61935", "WBGene00020386", "O62377", "WBGene00011699", "O62378", "WBGene00011698", "P90771", "WBGene00007913", "Q20315", "WBGene00018333", "A0A0M7RF98", "WBGene00018264", "Q27465", "WBGene00015135", "G5ECD0", "WBGene00007362", "Q27470", "WBGene00015709", "G5EE22", "WBGene00012448", "Q27471", "WBGene00016092", "H2KY69", "WBGene00015044", "Q27482", "WBGene00016768", "H2KYS3", "WBGene00000905", "Q27499", "WBGene00018334", "O02627", "WBGene00015399", "Q965T7", "WBGene00021710", "O02628", "WBGene00015400", "Q9N4Q4", "WBGene00021168", "O02641", "WBGene00019967", "Q9N5I1", "WBGene00019565", "O16220", "WBGene00016786", "O16362", "WBGene00018413", "O16482", "WBGene00016860", "O16670", "WBGene00018262", "O16671", "WBGene00018261", "O16673", "WBGene00018260", "O44649", "WBGene00019473", "O44650", "WBGene00019472", "O44651", "WBGene00019471", "O44652", "WBGene00019470", "O44655", "WBGene00015040", "O44656", "WBGene00015041", "O44657", "WBGene00015042", "O44658", "WBGene00015043", "O44704", "WBGene00016686", "O44706", "WBGene00016697", "O45364", "WBGene00008829" ] }, "reaction_10519552": { "compartment": "compartment_70101", "id": "reaction_10519552", "reactome": "R-CEL-377644", "name": "Release of CSK from SRC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10519544" ], "products": [ "species_10518223", "species_10519550" ], "modifiers": [], "additional_components": [ "species_74016", "species_266099", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "G5ECJ6", "WBGene00000812", "P34446", "WBGene00003929", "G5EGK1", "WBGene00006771", "species_179856", "Q18246", "WBGene00004307", "species_29438", "P34400", "WBGene00003243", "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769", "WBGene00000812", "species_74016", "species_266099", "G5EGK1", "WBGene00006771", "species_179856", "Q18246", "WBGene00004307", "species_29438", "P34400", "WBGene00003243", "P34446", "WBGene00003929", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769" ] }, "reaction_10518244": { "compartment": "compartment_70101", "id": "reaction_10518244", "reactome": "R-CEL-354087", "name": "Recruitment of GRB2 to p-PTK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10506871", "species_10518240" ], "products": [ "species_10518242" ], "modifiers": [], "additional_components": [ "WBGene00004774", "species_74016", "species_266099", "G5EGK1", "WBGene00006771", "species_179856", "Q18246", "WBGene00004307", "species_29438", "P34400", "WBGene00003243", "P34446", "WBGene00003929", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769", "Q95YD4", "WBGene00002213", "species_74016", "species_266099", "G5EGK1", "WBGene00006771", "species_179856", "Q18246", "WBGene00004307", "species_29438", "P34400", "WBGene00003243", "P34446", "WBGene00003929", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769", "Q95YD4", "WBGene00002213", "P29355", "WBGene00004774" ] }, "reaction_10518263": { "compartment": "compartment_70101", "id": "reaction_10518263", "reactome": "R-CEL-354165", "name": "Interaction of SOS with GRB2 bound to FADK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10506876", "species_10518242" ], "products": [ "species_10518261" ], "modifiers": [], "additional_components": [ "WBGene00004947", "species_74016", "species_266099", "G5EGK1", "WBGene00006771", "species_179856", "Q18246", "WBGene00004307", "species_29438", "P34400", "WBGene00003243", "P34446", "WBGene00003929", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769", "Q95YD4", "WBGene00002213", "P29355", "WBGene00004774", "species_74016", "species_266099", "G5EGK1", "WBGene00006771", "species_179856", "Q18246", "WBGene00004307", "species_29438", "P34400", "WBGene00003243", "P34446", "WBGene00003929", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769", "Q95YD4", "WBGene00002213", "P29355", "WBGene00004774", "Q9N5D3", "WBGene00004947" ] }, "reaction_10518210": { "compartment": "compartment_70101", "id": "reaction_10518210", "reactome": "R-CEL-354073", "name": "Autophosphorylation of PTK2 at Y397", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10518200" ], "products": [ "species_10518207", "species_29370" ], "modifiers": [ [ "species_10518200", "catalyst" ] ], "additional_components": [ "species_74016", "species_266099", "G5EGK1", "WBGene00006771", "species_179856", "Q18246", "WBGene00004307", "species_29438", "P34400", "WBGene00003243", "P34446", "WBGene00003929", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769", "Q95YD4", "WBGene00002213", "species_74016", "species_266099", "G5EGK1", "WBGene00006771", "species_179856", "Q18246", "WBGene00004307", "species_29438", "P34400", "WBGene00003243", "P34446", "WBGene00003929", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769", "Q95YD4", "WBGene00002213", "species_74016", "species_266099", "G5EGK1", "WBGene00006771", "species_179856", "Q18246", "WBGene00004307", "species_29438", "P34400", "WBGene00003243", "P34446", "WBGene00003929", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769", "Q95YD4", "WBGene00002213" ] }, "reaction_10518277": { "compartment": "compartment_70101", "id": "reaction_10518277", "reactome": "R-CEL-354173", "name": "Activation of Rap1 by cytosolic GEFs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10518265" ], "products": [ "species_29420", "species_10518164" ], "modifiers": [ [ "species_10518274", "catalyst" ] ], "additional_components": [ "Q18246", "WBGene00004307", "species_29420", "Q18246", "WBGene00004307", "species_29438", "species_74016", "species_114519", "Q19770", "WBGene00009100" ] }, "reaction_10518246": { "compartment": "compartment_70101", "id": "reaction_10518246", "reactome": "R-CEL-354097", "name": "Activation of Talin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10518171", "species_10518194" ], "products": [ "species_10518196" ], "modifiers": [], "additional_components": [ "species_179856", "Q18246", "WBGene00004307", "species_29438", "P34400", "WBGene00003243", "WBGene00006771", "G5EGK1", "WBGene00006771", "species_179856", "Q18246", "WBGene00004307", "species_29438", "P34400", "WBGene00003243" ] }, "reaction_10523400": { "compartment": "compartment_70101", "id": "reaction_10523400", "reactome": "R-CEL-429415", "name": "SYK binds to integrin alphaIIb beta3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10516474", "species_10518198" ], "products": [ "species_10523398" ], "modifiers": [], "additional_components": [ "WBGene00016416", "species_74016", "species_266099", "G5EGK1", "WBGene00006771", "species_179856", "Q18246", "WBGene00004307", "species_29438", "P34400", "WBGene00003243", "P34446", "WBGene00003929", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769", "species_74016", "species_266099", "G5EGK1", "WBGene00006771", "species_179856", "Q18246", "WBGene00004307", "species_29438", "P34400", "WBGene00003243", "P34446", "WBGene00003929", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769", "Q18462", "WBGene00016416" ] }, "reaction_10518255": { "compartment": "compartment_70101", "id": "reaction_10518255", "reactome": "R-CEL-354124", "name": "Phosphorylation of pPTK2 by SRC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10518207", "species_113592" ], "products": [ "species_29370", "species_10518240" ], "modifiers": [ [ "species_10518207", "catalyst" ] ], "additional_components": [ "species_74016", "species_266099", "G5EGK1", "WBGene00006771", "species_179856", "Q18246", "WBGene00004307", "species_29438", "P34400", "WBGene00003243", "P34446", "WBGene00003929", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769", "Q95YD4", "WBGene00002213", "species_74016", "species_266099", "G5EGK1", "WBGene00006771", "species_179856", "Q18246", "WBGene00004307", "species_29438", "P34400", "WBGene00003243", "P34446", "WBGene00003929", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769", "Q95YD4", "WBGene00002213", "species_74016", "species_266099", "G5EGK1", "WBGene00006771", "species_179856", "Q18246", "WBGene00004307", "species_29438", "P34400", "WBGene00003243", "P34446", "WBGene00003929", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769", "Q95YD4", "WBGene00002213" ] }, "reaction_10523408": { "compartment": "compartment_70101", "id": "reaction_10523408", "reactome": "R-CEL-429441", "name": "SYK activation by SRC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10523398" ], "products": [ "species_10523405", "species_29370" ], "modifiers": [ [ "species_10523398", "catalyst" ] ], "additional_components": [ "species_74016", "species_266099", "G5EGK1", "WBGene00006771", "species_179856", "Q18246", "WBGene00004307", "species_29438", "P34400", "WBGene00003243", "P34446", "WBGene00003929", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769", "Q18462", "WBGene00016416", "species_74016", "species_266099", "G5EGK1", "WBGene00006771", "species_179856", "Q18246", "WBGene00004307", "species_29438", "P34400", "WBGene00003243", "P34446", "WBGene00003929", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769", "Q18462", "WBGene00016416", "species_74016", "species_266099", "G5EGK1", "WBGene00006771", "species_179856", "Q18246", "WBGene00004307", "species_29438", "P34400", "WBGene00003243", "P34446", "WBGene00003929", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769", "Q18462", "WBGene00016416" ] }, "reaction_10529458": { "compartment": "compartment_70101", "id": "reaction_10529458", "reactome": "R-CEL-939265", "name": "Activation of Rap1 by membrane-associated GEFs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10518265" ], "products": [ "species_29420", "species_10518164" ], "modifiers": [ [ "species_10520078", "catalyst" ] ], "additional_components": [ "Q18246", "WBGene00004307", "species_29420", "Q18246", "WBGene00004307", "species_29438", "WBGene00004255" ] }, "reaction_10518259": { "compartment": "compartment_984", "id": "reaction_10518259", "reactome": "R-CEL-354149", "name": "Interaction of integrin alphaIIb beta3 with Fibrinogen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10515311", "species_10518229", "species_377604" ], "products": [ "species_10518257" ], "modifiers": [], "additional_components": [ "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "G5ECJ6", "WBGene00000812", "P34446", "WBGene00003929", "G5EGK1", "WBGene00006771", "species_179856", "Q18246", "WBGene00004307", "species_29438", "P34400", "WBGene00003243", "species_74016", "species_266099", "species_74016", "species_266099", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "G5ECJ6", "WBGene00000812", "P34446", "WBGene00003929", "G5EGK1", "WBGene00006771", "species_179856", "Q18246", "WBGene00004307", "species_29438", "P34400", "WBGene00003243", "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769" ] }, "reaction_10519542": { "compartment": "compartment_70101", "id": "reaction_10519542", "reactome": "R-CEL-377640", "name": "Autophosphorylation of SRC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10519539" ], "products": [ "species_29370", "species_10518198" ], "modifiers": [ [ "species_10513079", "catalyst" ] ], "additional_components": [ "species_74016", "species_266099", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "P34446", "WBGene00003929", "G5EGK1", "WBGene00006771", "species_179856", "Q18246", "WBGene00004307", "species_29438", "P34400", "WBGene00003243", "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769", "species_74016", "species_266099", "G5EGK1", "WBGene00006771", "species_179856", "Q18246", "WBGene00004307", "species_29438", "P34400", "WBGene00003243", "P34446", "WBGene00003929", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635" ] }, "reaction_10518231": { "compartment": "compartment_876", "id": "reaction_10518231", "reactome": "R-CEL-354077", "name": "Integrin alphaIIb beta3 activation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10518196", "species_10518227" ], "products": [ "species_10518229" ], "modifiers": [], "additional_components": [ "G5EGK1", "WBGene00006771", "species_179856", "Q18246", "WBGene00004307", "species_29438", "P34400", "WBGene00003243", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "G5ECJ6", "WBGene00000812", "P34446", "WBGene00003929", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "G5ECJ6", "WBGene00000812", "P34446", "WBGene00003929", "G5EGK1", "WBGene00006771", "species_179856", "Q18246", "WBGene00004307", "species_29438", "P34400", "WBGene00003243" ] }, "reaction_10519546": { "compartment": "compartment_876", "id": "reaction_10519546", "reactome": "R-CEL-377641", "name": "Clustering of Integrin alphaIIb beta3 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10518227", "species_10518257" ], "products": [ "species_10519544" ], "modifiers": [], "additional_components": [ "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "G5ECJ6", "WBGene00000812", "P34446", "WBGene00003929", "species_74016", "species_266099", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "G5ECJ6", "WBGene00000812", "P34446", "WBGene00003929", "G5EGK1", "WBGene00006771", "species_179856", "Q18246", "WBGene00004307", "species_29438", "P34400", "WBGene00003243", "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769", "species_74016", "species_266099", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "G5ECJ6", "WBGene00000812", "P34446", "WBGene00003929", "G5EGK1", "WBGene00006771", "species_179856", "Q18246", "WBGene00004307", "species_29438", "P34400", "WBGene00003243", "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769" ] }, "reaction_10518202": { "compartment": "compartment_70101", "id": "reaction_10518202", "reactome": "R-CEL-354066", "name": "Translocation of PTK2 to Focal complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10514906", "species_10518198" ], "products": [ "species_10518200" ], "modifiers": [], "additional_components": [ "WBGene00002213", "species_74016", "species_266099", "G5EGK1", "WBGene00006771", "species_179856", "Q18246", "WBGene00004307", "species_29438", "P34400", "WBGene00003243", "P34446", "WBGene00003929", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769", "species_74016", "species_266099", "G5EGK1", "WBGene00006771", "species_179856", "Q18246", "WBGene00004307", "species_29438", "P34400", "WBGene00003243", "P34446", "WBGene00003929", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769", "Q95YD4", "WBGene00002213" ] }, "reaction_10524570": { "compartment": "compartment_876", "id": "reaction_10524570", "reactome": "R-CEL-443905", "name": "SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10524564" ], "products": [ "species_10524568" ], "modifiers": [], "additional_components": [ "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "G5ECJ6", "WBGene00000812", "P34446", "WBGene00003929", "G5EGK1", "WBGene00006771", "species_179856", "Q18246", "WBGene00004307", "species_29438", "P34400", "WBGene00003243", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "G5ECJ6", "WBGene00000812", "P34446", "WBGene00003929", "G5EGK1", "WBGene00006771", "species_179856", "Q18246", "WBGene00004307", "species_29438", "P34400", "WBGene00003243" ] }, "reaction_10518173": { "compartment": "compartment_70101", "id": "reaction_10518173", "reactome": "R-CEL-354060", "name": "Translocation of RIAM to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10518169", "species_10518164", "species_179856" ], "products": [ "species_10518171" ], "modifiers": [], "additional_components": [ "WBGene00003243", "Q18246", "WBGene00004307", "species_29438", "species_179856", "Q18246", "WBGene00004307", "species_29438", "P34400", "WBGene00003243" ] }, "reaction_10503824": { "compartment": "compartment_70101", "id": "reaction_10503824", "reactome": "R-CEL-71188", "name": "TDO tetramer dioxygenates L-Trp to NFK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29500", "species_29368" ], "products": [ "species_33179" ], "modifiers": [ [ "species_10503821", "catalyst" ] ], "additional_components": [ "species_71185", "Q09474", "WBGene00016201" ] }, "reaction_10503843": { "compartment": "compartment_70101", "id": "reaction_10503843", "reactome": "R-CEL-71217", "name": "3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_34351", "species_29356" ], "products": [ "species_29432", "species_30487" ], "modifiers": [ [ "species_10503840", "catalyst" ] ], "additional_components": [ "Q18026", "WBGene00015802" ] }, "reaction_10503832": { "compartment": "compartment_70101", "id": "reaction_10503832", "reactome": "R-CEL-71200", "name": "kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29368", "species_29364", "species_29970" ], "products": [ "species_34351", "species_29356", "species_29366" ], "modifiers": [ [ "species_10503829", "catalyst" ] ], "additional_components": [ "WBGene00011089" ] }, "reaction_10528412": { "compartment": "compartment_70101", "id": "reaction_10528412", "reactome": "R-CEL-893596", "name": "PXLP-KYAT1 dimer transaminates L-KYN to AP-DOBu", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29398", "species_29970" ], "products": [ "species_29432", "species_893615" ], "modifiers": [ [ "species_10528406", "catalyst" ], [ "species_29502", "inhibitor" ], [ "species_8939576", "inhibitor" ] ], "additional_components": [ "Q9XX97", "WBGene00009232", "Q8MP09", "WBGene00010984", "CHEBI:55528", "CHEBI:43580" ] }, "reaction_10503853": { "compartment": "compartment_70101", "id": "reaction_10503853", "reactome": "R-CEL-71218", "name": "3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_30487" ], "products": [ "species_36027" ], "modifiers": [ [ "species_10503850", "catalyst" ] ], "additional_components": [ "Q19341", "WBGene00010595", "species_113531" ] }, "reaction_10566750": { "compartment": "compartment_876", "id": "reaction_10566750", "reactome": "R-CEL-8870352", "name": "SLC36A4 transports L-Trp from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352006" ], "products": [ "species_29500" ], "modifiers": [ [ "species_10566747", "catalyst" ] ], "additional_components": [ "O45936", "WBGene00012804", "O62286", "WBGene00010421", "P34479", "WBGene00010307", "Q18595", "WBGene00016628", "Q9XX44", "WBGene00012629", "G4SQY7", "WBGene00020837" ] }, "reaction_10542434": { "compartment": "compartment_17951", "id": "reaction_10542434", "reactome": "R-CEL-2066778", "name": "Hydration of delta2-tetracosaheptaenoyl-CoA to 3-hydroxy tetracosahexaenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_141343", "species_2066767" ], "products": [ "species_2066766" ], "modifiers": [ [ "species_10513270", "catalyst" ] ], "additional_components": [ "Q19058", "WBGene00017123" ] }, "reaction_10542291": { "compartment": "compartment_12045", "id": "reaction_10542291", "reactome": "R-CEL-2046084", "name": "Desaturation of alpha-linoleoyl-CoA to Stearidonoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_194697", "species_2046062" ], "products": [ "species_194653", "species_113519", "species_2046052" ], "modifiers": [ [ "species_10542288", "catalyst" ] ], "additional_components": [ "WBGene00001395" ] }, "reaction_10542308": { "compartment": "compartment_17957", "id": "reaction_10542308", "reactome": "R-CEL-2046089", "name": "Desaturation of eicosatetraenoyl-CoA to eicosapentaenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_2046051", "species_194697" ], "products": [ "species_194653", "species_113519", "species_2046059" ], "modifiers": [ [ "species_10542305", "catalyst" ] ], "additional_components": [ "G5EG11", "WBGene00001396", "Q23221", "WBGene00001395" ] }, "reaction_10542436": { "compartment": "compartment_17951", "id": "reaction_10542436", "reactome": "R-CEL-2066779", "name": "Conversion of DHA-CoA to docosahexaenoic acid (DHA)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_141343", "species_2066765" ], "products": [ "species_193514", "species_2066763" ], "modifiers": [ [ "species_10513389", "catalyst" ] ], "additional_components": [ "WBGene00015887" ] }, "reaction_10542294": { "compartment": "compartment_17957", "id": "reaction_10542294", "reactome": "R-CEL-2046087", "name": "Translocation of tetracosahexaenoyl-CoA to peroxisomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2046054", "species_211579" ], "products": [ "species_426639", "species_211606", "species_2046047" ], "modifiers": [ [ "species_10520379", "catalyst" ] ], "additional_components": [ "WBGene00004061" ] }, "reaction_10542438": { "compartment": "compartment_17951", "id": "reaction_10542438", "reactome": "R-CEL-2066780", "name": "Dehydrogenation of 3-hydroxy tetracosahexaenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2066766" ], "products": [ "species_2066762" ], "modifiers": [ [ "species_10513270", "catalyst" ] ], "additional_components": [ "Q19058", "WBGene00017123" ] }, "reaction_10542296": { "compartment": "compartment_17957", "id": "reaction_10542296", "reactome": "R-CEL-2046088", "name": "Elongation of stearidonoyl-CoA to eicosatetraenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2046066", "species_2046052", "species_113601" ], "products": [ "species_113519", "species_113564", "species_2046051", "species_162743", "species_159751" ], "modifiers": [ [ "species_10527261", "catalyst" ] ], "additional_components": [ "WBGene00001241" ] }, "reaction_10542440": { "compartment": "compartment_17951", "id": "reaction_10542440", "reactome": "R-CEL-2066787", "name": "Oxidation of tetracosapentaenoyl-CoA to delta2-tetracosaheptaenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113535", "species_2046047" ], "products": [ "species_113575", "species_2066767" ], "modifiers": [ [ "species_10520766", "catalyst" ] ], "additional_components": [ "species_113596", "O62138", "WBGene00008566" ] }, "reaction_10567994": { "compartment": "compartment_70101", "id": "reaction_10567994", "reactome": "R-CEL-8932355", "name": "26S proteasome degrades Ub-NFE2L2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10567992" ], "products": [ "species_10502375" ], "modifiers": [ [ "species_10502572", "catalyst" ] ], "additional_components": [ "P34707", "WBGene00004804", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "P91477", "WBGene00003950", "Q95PZ7", "WBGene00013435", "Q18115", "WBGene00004459", "O62102", "WBGene00003948", "O17071", "WBGene00004504", "Q10920", "WBGene00016623", "P34286", "WBGene00003952", "Q9XTT9", "WBGene00004506", "Q23449", "WBGene00004468", "Q95005", "WBGene00003925", "P46502", "WBGene00004503", "O61792", "WBGene00004464", "O17586", "WBGene00003922", "O76371", "WBGene00004505", "Q20585", "WBGene00004463", "Q95008", "WBGene00003926", "Q18787", "WBGene00004501", "Q20058", "WBGene00009445", "Q9N599", "WBGene00003924", "O16368", "WBGene00004502", "O61742", "WBGene00004466", "Q09583", "WBGene00003928", "Q966I8", "WBGene00003947", "Q04908", "WBGene00004460", "Q9XUV0", "WBGene00003951", "Q27488", "WBGene00003923", "Q9GZH5", "WBGene00004458", "O44156", "WBGene00003927", "Q22253", "WBGene00004465", "O76577", "WBGene00004467", "P90868", "WBGene00003953", "Q19324", "WBGene00004461", "Q17971", "WBGene00007588", "Q23237", "WBGene00003949", "Q20938", "WBGene00004462" ] }, "reaction_10573338": { "compartment": "compartment_70101", "id": "reaction_10573338", "reactome": "R-CEL-9712274", "name": "NFE2L2 inducers bind to KEAP1:CUL3:RBX1:NFE2L2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10567990", "species_9714134" ], "products": [ "species_10573336" ], "modifiers": [], "additional_components": [ "P34707", "WBGene00004804", "Q23457", "WBGene00004320", "Q17391", "WBGene00000838", "P34707", "WBGene00004804", "Q23457", "WBGene00004320", "Q17391", "WBGene00000838" ] }, "reaction_10567982": { "compartment": "compartment_70101", "id": "reaction_10567982", "reactome": "R-CEL-8932309", "name": "NFE2L2 translocates from cytosol to nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10567974" ], "products": [ "species_10567980" ], "modifiers": [], "additional_components": [] }, "reaction_10553087": { "compartment": "compartment_876", "id": "reaction_10553087", "reactome": "R-CEL-5621363", "name": "SYK phosphorylates PLCG2 in p-6Y-SYK:p-Y65,Y76-FCER1G:PLCG2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10553084", "species_113592" ], "products": [ "species_10553082", "species_29370" ], "modifiers": [ [ "species_10553084", "catalyst" ] ], "additional_components": [ "Q22070", "WBGene00004038", "Q18462", "WBGene00016416", "Q22070", "WBGene00004038", "Q18462", "WBGene00016416", "Q22070", "WBGene00004038", "Q18462", "WBGene00016416" ] }, "reaction_10565886": { "compartment": "compartment_876", "id": "reaction_10565886", "reactome": "R-CEL-8858500", "name": "CLEC10A binds Tn-MUC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10565882", "species_10565876" ], "products": [ "species_10565884" ], "modifiers": [], "additional_components": [ "Q9U2D6", "WBGene00012901", "P34501", "WBGene00010540", "Q9N4W4", "WBGene00021602", "Q9N4W5", "WBGene00021603", "O18076", "WBGene00011668", "O44871", "WBGene00019914", "P91214", "WBGene00017199", "Q21146", "WBGene00019328", "Q9N4W4", "WBGene00021602", "Q9N4W5", "WBGene00021603", "O18076", "WBGene00011668", "O44871", "WBGene00019914", "P91214", "WBGene00017199", "Q21146", "WBGene00019328", "Q9U2D6", "WBGene00012901", "P34501", "WBGene00010540" ] }, "reaction_10531875": { "compartment": "compartment_20699", "id": "reaction_10531875", "reactome": "R-CEL-1028788", "name": "FUT8 transfers fucosyl group from GDP-Fuc to GlcNAc of NGP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_975910", "species_205683" ], "products": [ "species_205689", "species_1028779" ], "modifiers": [ [ "species_10531872", "catalyst" ] ], "additional_components": [ "WBGene00001508" ] }, "reaction_10530580": { "compartment": "compartment_20699", "id": "reaction_10530580", "reactome": "R-CEL-975814", "name": "Trimming of mannoses on the alpha1,6 arm by MAN2A1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_964837" ], "products": [ "species_964752", "species_975819" ], "modifiers": [ [ "species_10530577", "catalyst" ] ], "additional_components": [ "species_216785", "Q2PJ74", "WBGene00010284" ] }, "reaction_10557159": { "compartment": "compartment_17963", "id": "reaction_10557159", "reactome": "R-CEL-5693925", "name": "FUT3 transfers L-fucose to Gal1,3GlcNAc", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5693930", "species_205683" ], "products": [ "species_5693933", "species_205689" ], "modifiers": [ [ "species_10557156", "catalyst" ] ], "additional_components": [ "WBGene00016163" ] }, "reaction_10530588": { "compartment": "compartment_20699", "id": "reaction_10530588", "reactome": "R-CEL-975829", "name": "Addition of a GlcNAc on the alpha 1,4 branch by MGAT2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_914003", "species_975819" ], "products": [ "species_205687", "species_975822" ], "modifiers": [ [ "species_10530585", "catalyst" ] ], "additional_components": [ "WBGene00001645" ] }, "reaction_10557151": { "compartment": "compartment_161320", "id": "reaction_10557151", "reactome": "R-CEL-5693807", "name": "FUCA1 hydrolyses NGP:1,6-GlcNAc", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_6784247" ], "products": [ "species_6784248", "species_6784249" ], "modifiers": [ [ "species_10557148", "catalyst" ] ], "additional_components": [ "P49713", "WBGene00012225" ] }, "reaction_10502093": { "compartment": "compartment_7660", "id": "reaction_10502093", "reactome": "R-CEL-68637", "name": "CDC6 protein is synthesized under the control of E2F transcription factors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [], "products": [ "species_10502084" ], "modifiers": [ [ "species_10502089", "catalyst" ] ], "additional_components": [ "WBGene00000382", "WBGene00001162" ] }, "reaction_10508790": { "compartment": "compartment_7660", "id": "reaction_10508790", "reactome": "R-CEL-110349", "name": "Displacement of UNG glycosylase by APEX1 at the AP site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508670", "species_10508786" ], "products": [ "species_10508664", "species_10508788" ], "modifiers": [], "additional_components": [ "Q9U221", "WBGene00013241", "WBGene00001372", "WBGene00013241", "G5EBR7", "WBGene00001372" ] }, "reaction_10508792": { "compartment": "compartment_7660", "id": "reaction_10508792", "reactome": "R-CEL-110352", "name": "Displacement of NTHL1 glycosylase by APEX1 at the AP site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508686", "species_10508786" ], "products": [ "species_10508788", "species_10508657" ], "modifiers": [], "additional_components": [ "P54137", "WBGene00011201", "WBGene00001372", "G5EBR7", "WBGene00001372", "WBGene00011201" ] }, "reaction_10529620": { "compartment": "compartment_20699", "id": "reaction_10529620", "reactome": "R-CEL-964825", "name": "Progressive trimming of alpha-1,2-linked mannose residues from Man8GlcNAc2 to produce Man5GlcNAc2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_964831" ], "products": [ "species_964752", "species_964740" ], "modifiers": [ [ "species_10529593", "catalyst" ] ], "additional_components": [ "CHEBI:60629", "CHEBI:60628", "CHEBI:60627", "P90787", "WBGene00008411", "Q18788", "WBGene00008258" ] }, "reaction_10529622": { "compartment": "compartment_20699", "id": "reaction_10529622", "reactome": "R-CEL-964830", "name": "Progressive trimming of alpha-1,2-linked mannose residues from Man7GlcNAc2 to produce Man5GlcNAc2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_964828" ], "products": [ "species_964752", "species_964740" ], "modifiers": [ [ "species_10529593", "catalyst" ] ], "additional_components": [ "P90787", "WBGene00008411", "Q18788", "WBGene00008258" ] }, "reaction_10529596": { "compartment": "compartment_20699", "id": "reaction_10529596", "reactome": "R-CEL-964737", "name": "Progressive trimming of alpha-1,2-linked mannose residues from Man9GlcNAc2 to produce Man5GlcNAc2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_915149" ], "products": [ "species_964752", "species_964740" ], "modifiers": [ [ "species_10529593", "catalyst" ] ], "additional_components": [ "P90787", "WBGene00008411", "Q18788", "WBGene00008258" ] }, "reaction_10568853": { "compartment": "compartment_70101", "id": "reaction_10568853", "reactome": "R-CEL-8948757", "name": "AKT phosphorylates MKRN1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10531086", "species_113592" ], "products": [ "species_29370", "species_10568851" ], "modifiers": [ [ "species_10513848", "catalyst" ] ], "additional_components": [ "WBGene00002278", "WBGene00002278", "Q9XTG7", "WBGene00000103", "G4S4W1", "WBGene00016980", "Q17941", "WBGene00000102" ] }, "reaction_10513917": { "compartment": "compartment_70101", "id": "reaction_10513917", "reactome": "R-CEL-198621", "name": "AKT phosphorylates caspase-9", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10509443" ], "products": [ "species_10513915", "species_29370" ], "modifiers": [ [ "species_10513848", "catalyst" ] ], "additional_components": [ "P42573", "WBGene00000417", "G5EBM1", "WBGene00000819", "G5EBM1", "WBGene00000819", "P42573", "WBGene00000417", "Q9XTG7", "WBGene00000103", "G4S4W1", "WBGene00016980", "Q17941", "WBGene00000102" ] }, "reaction_10523796": { "compartment": "compartment_876", "id": "reaction_10523796", "reactome": "R-CEL-432049", "name": "Aquaporin-9 passively transports glycerol into cell", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_192438" ], "products": [ "species_76116" ], "modifiers": [ [ "species_10523793", "catalyst" ] ], "additional_components": [ "Q7YWQ1", "WBGene00013272", "Q17571", "WBGene00000170", "Q7Z138", "WBGene00000176", "Q19949", "WBGene00000169", "Q9XW36", "WBGene00000171", "Q21473", "WBGene00000175" ] }, "reaction_10523803": { "compartment": "compartment_876", "id": "reaction_10523803", "reactome": "R-CEL-432074", "name": "Aquaporin-7 passively transports glycerol out of cell", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76116" ], "products": [ "species_192438" ], "modifiers": [ [ "species_10523800", "catalyst" ] ], "additional_components": [ "Q9XW36", "WBGene00000171" ] }, "reaction_10530450": { "compartment": "compartment_876", "id": "reaction_10530450", "reactome": "R-CEL-975389", "name": "GLRA:GLRB:Gly transports extracellular Cl- to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_188972" ], "products": [ "species_352022" ], "modifiers": [ [ "species_10530447", "catalyst" ] ], "additional_components": [ "species_159549", "G5EBR3", "WBGene00001591", "Q95QT7", "WBGene00001594", "G5ECH3", "WBGene00000233", "Q95Y52", "WBGene00022106", "G5EDN0", "WBGene00018880", "Q9GQ00", "WBGene00003386", "G5EEC1", "WBGene00013746", "Q9NA62", "WBGene00013517", "G5EEX8", "WBGene00009799", "Q9U358", "WBGene00012099", "G5EEZ3", "WBGene00001593", "X5LVB0", "WBGene00017399", "H2KYN9", "WBGene00020657", "O17041", "WBGene00020528", "P41849", "WBGene00020605", "P91985", "WBGene00008223", "Q10052", "WBGene00001588", "Q17328", "WBGene00001592", "Q18812", "WBGene00008280", "Q21005", "WBGene00010275", "Q21420", "WBGene00010741", "Q95Q97", "WBGene00000232" ] }, "reaction_10572690": { "compartment": "compartment_876", "id": "reaction_10572690", "reactome": "R-CEL-9648983", "name": "HTR3A pentamer:5HT transports Na+,K+,Ca2+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74126", "species_74112", "species_74113" ], "products": [ "species_29804", "species_83910", "species_74016" ], "modifiers": [ [ "species_10572687", "catalyst" ] ], "additional_components": [ "O76554", "WBGene00000955", "P54244", "WBGene00000951", "P54245", "WBGene00017580", "P54246", "WBGene00000044", "Q19351", "WBGene00017375", "Q22079", "WBGene00011354", "Q22080", "WBGene00011355", "Q22081", "WBGene00011356", "Q22083", "WBGene00011358", "Q22084", "WBGene00011360", "Q22085", "WBGene00011359", "Q6BEQ0", "WBGene00013338", "Q6F6K3", "WBGene00000056", "Q95Y94", "WBGene00020048", "Q9NAM5", "WBGene00013655", "V6CJ96", "WBGene00022247", "A0A3P6P985", "WBGene00000060", "B1Q281", "WBGene00000059", "G5ECT0", "WBGene00012857", "G5EG72", "WBGene00000057", "G5EG88", "WBGene00000062", "G5EGR1", "WBGene00000061", "H2KML8", "WBGene00013534", "O16426", "WBGene00020236", "O18228", "WBGene00013300", "O44452", "WBGene00015412", "O61519", "WBGene00017544", "O61520", "WBGene00017543", "species_380585" ] }, "reaction_10527788": { "compartment": "compartment_70101", "id": "reaction_10527788", "reactome": "R-CEL-629595", "name": "Activation of highly calcium permeable postsynaptic nicotinic acetylcholine receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74112" ], "products": [ "species_74016" ], "modifiers": [ [ "species_10527785", "catalyst" ] ], "additional_components": [ "A0A3P6P985", "WBGene00000060", "P48182", "WBGene00000042", "Q9N587", "WBGene00006797", "G5EDF1", "WBGene00000051", "Q93149", "WBGene00000043", "Q23022", "WBGene00006774", "O17274", "WBGene00020836", "Q93329", "WBGene00002975", "Q23355", "WBGene00000047", "P48181", "WBGene00006765", "Q9N4M3", "WBGene00000045", "Q27218", "WBGene00002974", "H2KZY7", "WBGene00022283", "B3WFZ2", "WBGene00000058", "species_372533" ] }, "reaction_10527790": { "compartment": "compartment_984", "id": "reaction_10527790", "reactome": "R-CEL-629596", "name": "Binding of acetylcholine to highly calcium permeable postsynaptic nicotinic acetylcholine receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10527783", "species_372533" ], "products": [ "species_10527785" ], "modifiers": [], "additional_components": [ "A0A3P6P985", "WBGene00000060", "P48182", "WBGene00000042", "Q9N587", "WBGene00006797", "G5EDF1", "WBGene00000051", "Q93149", "WBGene00000043", "Q23022", "WBGene00006774", "O17274", "WBGene00020836", "Q93329", "WBGene00002975", "Q23355", "WBGene00000047", "P48181", "WBGene00006765", "Q9N4M3", "WBGene00000045", "Q27218", "WBGene00002974", "H2KZY7", "WBGene00022283", "B3WFZ2", "WBGene00000058", "A0A3P6P985", "WBGene00000060", "P48182", "WBGene00000042", "Q9N587", "WBGene00006797", "G5EDF1", "WBGene00000051", "Q93149", "WBGene00000043", "Q23022", "WBGene00006774", "O17274", "WBGene00020836", "Q93329", "WBGene00002975", "Q23355", "WBGene00000047", "P48181", "WBGene00006765", "Q9N4M3", "WBGene00000045", "Q27218", "WBGene00002974", "H2KZY7", "WBGene00022283", "B3WFZ2", "WBGene00000058", "species_372533" ] }, "reaction_10527792": { "compartment": "compartment_984", "id": "reaction_10527792", "reactome": "R-CEL-629599", "name": "Binding of acetylcholine to highly calcium permeable acetylcholine receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_372533", "species_10527760" ], "products": [ "species_10527762" ], "modifiers": [], "additional_components": [ "O17274", "WBGene00020836", "Q9N4M3", "WBGene00000045", "P48181", "WBGene00006765", "Q9N587", "WBGene00006797", "P48182", "WBGene00000042", "Q23022", "WBGene00006774", "Q23355", "WBGene00000047", "Q27218", "WBGene00002974", "Q93149", "WBGene00000043", "G5EDF1", "WBGene00000051", "Q93329", "WBGene00002975", "H2KZY7", "WBGene00022283", "O17274", "WBGene00020836", "Q9N4M3", "WBGene00000045", "P48181", "WBGene00006765", "Q9N587", "WBGene00006797", "P48182", "WBGene00000042", "Q23022", "WBGene00006774", "Q23355", "WBGene00000047", "Q27218", "WBGene00002974", "Q93149", "WBGene00000043", "G5EDF1", "WBGene00000051", "Q93329", "WBGene00002975", "H2KZY7", "WBGene00022283", "species_372533" ] }, "reaction_10527765": { "compartment": "compartment_876", "id": "reaction_10527765", "reactome": "R-CEL-622326", "name": "Activation of highly calcium permeable nicotinic acetylcholine receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74112" ], "products": [ "species_74016" ], "modifiers": [ [ "species_10527762", "catalyst" ] ], "additional_components": [ "O17274", "WBGene00020836", "Q9N4M3", "WBGene00000045", "P48181", "WBGene00006765", "Q9N587", "WBGene00006797", "P48182", "WBGene00000042", "Q23022", "WBGene00006774", "Q23355", "WBGene00000047", "Q27218", "WBGene00002974", "Q93149", "WBGene00000043", "G5EDF1", "WBGene00000051", "Q93329", "WBGene00002975", "H2KZY7", "WBGene00022283", "species_372533" ] }, "reaction_10572694": { "compartment": "compartment_876", "id": "reaction_10572694", "reactome": "R-CEL-9649108", "name": "HTR3A pentamer binds 5HT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_114523", "species_10572692" ], "products": [ "species_10572687" ], "modifiers": [], "additional_components": [ "O76554", "WBGene00000955", "P54244", "WBGene00000951", "P54245", "WBGene00017580", "P54246", "WBGene00000044", "Q19351", "WBGene00017375", "Q22079", "WBGene00011354", "Q22080", "WBGene00011355", "Q22081", "WBGene00011356", "Q22083", "WBGene00011358", "Q22084", "WBGene00011360", "Q22085", "WBGene00011359", "Q6BEQ0", "WBGene00013338", "Q6F6K3", "WBGene00000056", "Q95Y94", "WBGene00020048", "Q9NAM5", "WBGene00013655", "V6CJ96", "WBGene00022247", "A0A3P6P985", "WBGene00000060", "B1Q281", "WBGene00000059", "G5ECT0", "WBGene00012857", "G5EG72", "WBGene00000057", "G5EG88", "WBGene00000062", "G5EGR1", "WBGene00000061", "H2KML8", "WBGene00013534", "O16426", "WBGene00020236", "O18228", "WBGene00013300", "O44452", "WBGene00015412", "O61519", "WBGene00017544", "O61520", "WBGene00017543", "O76554", "WBGene00000955", "P54244", "WBGene00000951", "P54245", "WBGene00017580", "P54246", "WBGene00000044", "Q19351", "WBGene00017375", "Q22079", "WBGene00011354", "Q22080", "WBGene00011355", "Q22081", "WBGene00011356", "Q22083", "WBGene00011358", "Q22084", "WBGene00011360", "Q22085", "WBGene00011359", "Q6BEQ0", "WBGene00013338", "Q6F6K3", "WBGene00000056", "Q95Y94", "WBGene00020048", "Q9NAM5", "WBGene00013655", "V6CJ96", "WBGene00022247", "A0A3P6P985", "WBGene00000060", "B1Q281", "WBGene00000059", "G5ECT0", "WBGene00012857", "G5EG72", "WBGene00000057", "G5EG88", "WBGene00000062", "G5EGR1", "WBGene00000061", "H2KML8", "WBGene00013534", "O16426", "WBGene00020236", "O18228", "WBGene00013300", "O44452", "WBGene00015412", "O61519", "WBGene00017544", "O61520", "WBGene00017543", "species_380585" ] }, "reaction_10571568": { "compartment": "compartment_7660", "id": "reaction_10571568", "reactome": "R-CEL-9029434", "name": "p-S363,S380,T573 RS6K translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10571566" ], "products": [ "species_10524491" ], "modifiers": [], "additional_components": [ "Q21734", "WBGene00011352", "Q19858", "WBGene00017898", "Q21734", "WBGene00011352", "Q19858", "WBGene00017898" ] }, "reaction_10524494": { "compartment": "compartment_7660", "id": "reaction_10524494", "reactome": "R-CEL-442724", "name": "Phosphorylation of CREB1 by ribosomal protein S6 kinases (RSKs)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10514243" ], "products": [ "species_113582", "species_10514246" ], "modifiers": [ [ "species_10524491", "catalyst" ] ], "additional_components": [ "WBGene00000793", "WBGene00000793", "Q21734", "WBGene00011352", "Q19858", "WBGene00017898" ] }, "reaction_10572227": { "compartment": "compartment_70101", "id": "reaction_10572227", "reactome": "R-CEL-9619355", "name": "CaMKK autophosphorylates in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10572220", "species_113592" ], "products": [ "species_29370", "species_10572224" ], "modifiers": [ [ "species_10572220", "catalyst" ] ], "additional_components": [ "species_74016", "Q11083", "WBGene00020378", "P04630", "WBGene00000285", "G5EF37", "WBGene00003934", "A0A2C9C3L3", "WBGene00020378", "Q18136", "WBGene00006861", "Q09665", "WBGene00006583", "O02159", "WBGene00020378", "G5EDZ8", "WBGene00000288", "Q94288", "WBGene00000287", "Q09980", "WBGene00017394", "O16305", "WBGene00000552", "G5EEG0", "WBGene00000286", "Q3Y416", "WBGene00000518", "species_74016", "Q11083", "WBGene00020378", "P04630", "WBGene00000285", "G5EF37", "WBGene00003934", "A0A2C9C3L3", "WBGene00020378", "Q18136", "WBGene00006861", "Q09665", "WBGene00006583", "O02159", "WBGene00020378", "G5EDZ8", "WBGene00000288", "Q94288", "WBGene00000287", "Q09980", "WBGene00017394", "O16305", "WBGene00000552", "G5EEG0", "WBGene00000286", "Q3Y416", "WBGene00000518", "species_74016", "Q11083", "WBGene00020378", "P04630", "WBGene00000285", "G5EF37", "WBGene00003934", "A0A2C9C3L3", "WBGene00020378", "Q18136", "WBGene00006861", "Q09665", "WBGene00006583", "O02159", "WBGene00020378", "G5EDZ8", "WBGene00000288", "Q94288", "WBGene00000287", "Q09980", "WBGene00017394", "O16305", "WBGene00000552", "G5EEG0", "WBGene00000286", "Q3Y416", "WBGene00000518" ] }, "reaction_10572236": { "compartment": "compartment_70101", "id": "reaction_10572236", "reactome": "R-CEL-9619376", "name": "CAMK1 binds calmodulin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10572232", "species_10508995" ], "products": [ "species_10572234" ], "modifiers": [], "additional_components": [ "WBGene00000553", "species_74016", "Q11083", "WBGene00020378", "P04630", "WBGene00000285", "G5EF37", "WBGene00003934", "A0A2C9C3L3", "WBGene00020378", "Q18136", "WBGene00006861", "Q09665", "WBGene00006583", "O02159", "WBGene00020378", "G5EDZ8", "WBGene00000288", "Q94288", "WBGene00000287", "Q09980", "WBGene00017394", "O16305", "WBGene00000552", "G5EEG0", "WBGene00000286", "species_74016", "Q11083", "WBGene00020378", "P04630", "WBGene00000285", "G5EF37", "WBGene00003934", "A0A2C9C3L3", "WBGene00020378", "Q18136", "WBGene00006861", "Q09665", "WBGene00006583", "O02159", "WBGene00020378", "G5EDZ8", "WBGene00000288", "Q94288", "WBGene00000287", "Q09980", "WBGene00017394", "O16305", "WBGene00000552", "G5EEG0", "WBGene00000286", "Q9TXJ0", "WBGene00000553" ] }, "reaction_10523910": { "compartment": "compartment_984", "id": "reaction_10523910", "reactome": "R-CEL-432164", "name": "Ca2+ influx into the post-synaptic cell", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74112" ], "products": [ "species_74016" ], "modifiers": [ [ "species_10523907", "catalyst" ], [ "species_9635195", "inhibitor" ] ], "additional_components": [ "G5ECY0", "WBGene00001006", "Q22638", "WBGene00011890", "G5EEH3", "WBGene00003775", "G5EGQ9", "WBGene00003774", "Q23158", "WBGene00000228", "O61967", "WBGene00002632", "O62305", "WBGene00006779", "species_376186", "species_159549", "species_113552" ] }, "reaction_10524270": { "compartment": "compartment_876", "id": "reaction_10524270", "reactome": "R-CEL-438037", "name": "Membrane depolarization upon activation of Ca impermeable AMPA receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74113" ], "products": [ "species_83910" ], "modifiers": [ [ "species_10521150", "catalyst" ], [ "species_10524268", "catalyst" ] ], "additional_components": [ "Q10914", "WBGene00001613", "Q21415", "WBGene00001614", "Q8MXV8", "WBGene00001617", "P34299", "WBGene00001612", "species_113552", "O61967", "WBGene00002632", "G5ECY0", "WBGene00001006", "Q22638", "WBGene00011890", "G5EGQ9", "WBGene00003774", "G5EEH3", "WBGene00003775", "Q23158", "WBGene00000228", "O62305", "WBGene00006779", "species_376186", "species_159549", "species_113552", "species_74016", "Q11083", "WBGene00020378", "P04630", "WBGene00000285", "G5EF37", "WBGene00003934", "A0A2C9C3L3", "WBGene00020378", "Q18136", "WBGene00006861", "Q09665", "WBGene00006583", "O02159", "WBGene00020378", "G5EDZ8", "WBGene00000288", "Q94288", "WBGene00000287", "Q09980", "WBGene00017394", "O16305", "WBGene00000552", "G5EEG0", "WBGene00000286" ] }, "reaction_10571984": { "compartment": "compartment_12045", "id": "reaction_10571984", "reactome": "R-CEL-9609742", "name": "Formation of di-heterotetramers of GluN1 (GRIN1) and GluN2A (GRIN2A)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10571980", "species_10571978" ], "products": [ "species_10571982" ], "modifiers": [], "additional_components": [ "WBGene00003775", "WBGene00003774", "G5EGQ9", "WBGene00003774", "G5EEH3", "WBGene00003775" ] }, "reaction_10572100": { "compartment": "compartment_12045", "id": "reaction_10572100", "reactome": "R-CEL-9610750", "name": "GluN1:GluN2 (GRIN1:GRIN2) NMDA receptors traffic to the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10572098" ], "products": [ "species_10523874" ], "modifiers": [], "additional_components": [ "G5EEH3", "WBGene00003775", "G5EGQ9", "WBGene00003774", "G5EEH3", "WBGene00003775", "G5EGQ9", "WBGene00003774" ] }, "reaction_10530193": { "compartment": "compartment_876", "id": "reaction_10530193", "reactome": "R-CEL-975340", "name": "GABR heteropentamers:GABA transport Cl- from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_188972" ], "products": [ "species_352022" ], "modifiers": [ [ "species_10530190", "catalyst" ] ], "additional_components": [ "species_352003", "Q6BET0", "WBGene00008551", "G5ECN1", "WBGene00013914", "A5JYS3", "WBGene00045385", "Q17999", "WBGene00007594", "G5ECD3", "WBGene00006784", "Q4W520", "WBGene00044301", "G5ECJ0", "WBGene00001373", "A0A3P6NNS2", "WBGene00017389", "Q9U2E2", "WBGene00012915", "O18276", "WBGene00001512" ] }, "reaction_10530517": { "compartment": "compartment_876", "id": "reaction_10530517", "reactome": "R-CEL-975449", "name": "GABRR pentamers:GABA transports extracellular Cl- to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_188972" ], "products": [ "species_352022" ], "modifiers": [ [ "species_10530514", "catalyst" ] ], "additional_components": [ "Q4W520", "WBGene00044301", "Q9U2E2", "WBGene00012915", "A0A3P6NNS2", "WBGene00017389", "A5JYS3", "WBGene00045385", "G5ECD3", "WBGene00006784", "G5ECJ0", "WBGene00001373", "O18276", "WBGene00001512", "Q17999", "WBGene00007594", "species_352003" ] }, "reaction_10531856": { "compartment": "compartment_876", "id": "reaction_10531856", "reactome": "R-CEL-1013013", "name": "Association of GABA B receptor with G protein beta-gamma subunits", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509165", "species_10519831" ], "products": [ "species_10531752" ], "modifiers": [ [ "species_10519831", "catalyst" ] ], "additional_components": [ "P17343", "WBGene00001679", "P54406", "WBGene00001681", "G5ECB2", "WBGene00022675", "H2L0Q3", "WBGene00021528", "species_352003", "G5ECB2", "WBGene00022675", "H2L0Q3", "WBGene00021528", "species_352003", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "G5ECB2", "WBGene00022675", "H2L0Q3", "WBGene00021528", "species_352003" ] }, "reaction_10531859": { "compartment": "compartment_70101", "id": "reaction_10531859", "reactome": "R-CEL-1013020", "name": "Activation of GIRK/Kir3 Channels", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10531851", "catalyst" ] ], "additional_components": [ "G5ECB2", "WBGene00022675", "H2L0Q3", "WBGene00021528", "species_352003", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "A0A1C3NSK2", "WBGene00002151", "A0A1C3NSN6", "WBGene00002150", "P52192", "WBGene00002149" ] }, "reaction_10531854": { "compartment": "compartment_876", "id": "reaction_10531854", "reactome": "R-CEL-1013012", "name": "Binding of Gbeta/gamma to GIRK/Kir3 channels", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10531849", "species_10531752" ], "products": [ "species_10531851" ], "modifiers": [ [ "species_10519831", "catalyst" ] ], "additional_components": [ "A0A1C3NSK2", "WBGene00002151", "A0A1C3NSN6", "WBGene00002150", "P52192", "WBGene00002149", "G5ECB2", "WBGene00022675", "H2L0Q3", "WBGene00021528", "species_352003", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "G5ECB2", "WBGene00022675", "H2L0Q3", "WBGene00021528", "species_352003", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "A0A1C3NSK2", "WBGene00002151", "A0A1C3NSN6", "WBGene00002150", "P52192", "WBGene00002149", "G5ECB2", "WBGene00022675", "H2L0Q3", "WBGene00021528", "species_352003" ] }, "reaction_10522049": { "compartment": "compartment_984", "id": "reaction_10522049", "reactome": "R-CEL-420977", "name": "Ca permeable AMPA receptor ligand binding", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_210382", "species_10521159" ], "products": [ "species_10521161" ], "modifiers": [], "additional_components": [ "Q10914", "WBGene00001613", "Q21415", "WBGene00001614", "Q8MXV8", "WBGene00001617", "P34299", "WBGene00001612", "Q10914", "WBGene00001613", "Q21415", "WBGene00001614", "Q8MXV8", "WBGene00001617", "P34299", "WBGene00001612", "species_113552" ] }, "reaction_10521153": { "compartment": "compartment_876", "id": "reaction_10521153", "reactome": "R-CEL-399711", "name": "Activation of Ca impermeable AMPA receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74113" ], "products": [ "species_83910" ], "modifiers": [ [ "species_10521150", "catalyst" ] ], "additional_components": [ "Q10914", "WBGene00001613", "Q21415", "WBGene00001614", "Q8MXV8", "WBGene00001617", "P34299", "WBGene00001612", "species_113552" ] }, "reaction_10522051": { "compartment": "compartment_876", "id": "reaction_10522051", "reactome": "R-CEL-420980", "name": "Activation of Ca permeable AMPA receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74113" ], "products": [ "species_83910" ], "modifiers": [ [ "species_10521161", "catalyst" ] ], "additional_components": [ "Q10914", "WBGene00001613", "Q21415", "WBGene00001614", "Q8MXV8", "WBGene00001617", "P34299", "WBGene00001612", "species_113552" ] }, "reaction_10522047": { "compartment": "compartment_984", "id": "reaction_10522047", "reactome": "R-CEL-420975", "name": "Ca impermeable AMPA receptor ligand binding", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_210382", "species_10521148" ], "products": [ "species_10521150" ], "modifiers": [], "additional_components": [ "Q10914", "WBGene00001613", "Q21415", "WBGene00001614", "Q8MXV8", "WBGene00001617", "P34299", "WBGene00001612", "Q10914", "WBGene00001613", "Q21415", "WBGene00001614", "Q8MXV8", "WBGene00001617", "P34299", "WBGene00001612", "species_113552" ] }, "reaction_10530046": { "compartment": "compartment_876", "id": "reaction_10530046", "reactome": "R-CEL-975311", "name": "HTR3 pentamers:5HT transport Na+,K+,Ca2+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74126", "species_74112", "species_74113" ], "products": [ "species_29804", "species_83910", "species_74016" ], "modifiers": [ [ "species_10530043", "catalyst" ] ], "additional_components": [ "O76554", "WBGene00000955", "P54244", "WBGene00000951", "P54245", "WBGene00017580", "P54246", "WBGene00000044", "Q19351", "WBGene00017375", "Q22079", "WBGene00011354", "Q22080", "WBGene00011355", "Q22081", "WBGene00011356", "Q22083", "WBGene00011358", "Q22084", "WBGene00011360", "Q22085", "WBGene00011359", "Q6BEQ0", "WBGene00013338", "Q6F6K3", "WBGene00000056", "Q95Y94", "WBGene00020048", "Q9NAM5", "WBGene00013655", "V6CJ96", "WBGene00022247", "A0A3P6P985", "WBGene00000060", "B1Q281", "WBGene00000059", "G5ECT0", "WBGene00012857", "G5EG72", "WBGene00000057", "G5EG88", "WBGene00000062", "G5EGR1", "WBGene00000061", "H2KML8", "WBGene00013534", "O16426", "WBGene00020236", "O18228", "WBGene00013300", "O44452", "WBGene00015412", "O61519", "WBGene00017544", "O61520", "WBGene00017543", "species_380585" ] }, "reaction_10518753": { "compartment": "compartment_876", "id": "reaction_10518753", "reactome": "R-CEL-374680", "name": "L1 trans-homophilic interaction", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10518718", "species_10518749" ], "products": [ "species_10518751" ], "modifiers": [], "additional_components": [ "Q21465", "WBGene00019727", "Q5WRR1", "WBGene00006942", "G5EBK3", "WBGene00001333", "species_179856", "Q21465", "WBGene00019727", "Q5WRR1", "WBGene00006942", "G5EBK3", "WBGene00001333", "species_179856", "Q21465", "WBGene00019727", "Q5WRR1", "WBGene00006942" ] }, "reaction_10524545": { "compartment": "compartment_70101", "id": "reaction_10524545", "reactome": "R-CEL-443779", "name": "Linkage of L1 with treadmilling F-actin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10518751", "species_10523755" ], "products": [ "species_10524543" ], "modifiers": [], "additional_components": [ "G5EBK3", "WBGene00001333", "species_179856", "Q21465", "WBGene00019727", "Q5WRR1", "WBGene00006942", "P0DM41", "WBGene00000063", "P0DM42", "WBGene00000065", "P10984", "WBGene00000064", "P10986", "WBGene00000066", "species_29358", "P0DM41", "WBGene00000063", "P0DM42", "WBGene00000065", "P10984", "WBGene00000064", "P10986", "WBGene00000066", "species_29358", "G5EBK3", "WBGene00001333", "species_179856", "Q21465", "WBGene00019727", "Q5WRR1", "WBGene00006942" ] }, "reaction_10521063": { "compartment": "compartment_876", "id": "reaction_10521063", "reactome": "R-CEL-392748", "name": "L1 binds to AP-2 Clathrin complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10518718", "species_10512100" ], "products": [ "species_10521061" ], "modifiers": [], "additional_components": [ "Q21465", "WBGene00019727", "Q5WRR1", "WBGene00006942", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q21465", "WBGene00019727", "Q5WRR1", "WBGene00006942" ] }, "reaction_10527463": { "compartment": "compartment_876", "id": "reaction_10527463", "reactome": "R-CEL-555065", "name": "Formation of clathrin coated vesicle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10512105", "species_10521061" ], "products": [ "species_29372", "species_29420", "species_10521065" ], "modifiers": [ [ "species_10512940", "catalyst" ] ], "additional_components": [ "WBGene00006791", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q21465", "WBGene00019727", "Q5WRR1", "WBGene00006942", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "B1V8A0", "WBGene00006791", "Q21465", "WBGene00019727", "Q5WRR1", "WBGene00006942" ] }, "reaction_10524730": { "compartment": "compartment_70101", "id": "reaction_10524730", "reactome": "R-CEL-445079", "name": "Phosphorylation of L1 by ERK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10521065", "species_113592", "species_10508599" ], "products": [ "species_29370", "species_10524727" ], "modifiers": [ [ "species_10508599", "catalyst" ] ], "additional_components": [ "P34574", "WBGene00011867", "P90961", "WBGene00020246", "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "B1V8A0", "WBGene00006791", "Q21465", "WBGene00019727", "Q5WRR1", "WBGene00006942", "WBGene00003401", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q5WRR1", "WBGene00006942", "Q21465", "WBGene00019727", "P39745", "WBGene00003401", "B1V8A0", "WBGene00006791", "WBGene00003401" ] }, "reaction_10521067": { "compartment": "compartment_17940", "id": "reaction_10521067", "reactome": "R-CEL-392749", "name": "Transport of L1 into endosomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10521065" ], "products": [ "species_10521065" ], "modifiers": [], "additional_components": [ "P34574", "WBGene00011867", "P90961", "WBGene00020246", "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "B1V8A0", "WBGene00006791", "Q21465", "WBGene00019727", "Q5WRR1", "WBGene00006942", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "B1V8A0", "WBGene00006791", "Q21465", "WBGene00019727", "Q5WRR1", "WBGene00006942" ] }, "reaction_10524732": { "compartment": "compartment_70101", "id": "reaction_10524732", "reactome": "R-CEL-445084", "name": "Phosphorylation of L1 by SRC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10518718", "species_113592" ], "products": [ "species_10518747", "species_29370" ], "modifiers": [ [ "species_10513079", "catalyst" ] ], "additional_components": [ "Q21465", "WBGene00019727", "Q5WRR1", "WBGene00006942", "Q21465", "WBGene00019727", "Q5WRR1", "WBGene00006942", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635" ] }, "reaction_10524556": { "compartment": "compartment_876", "id": "reaction_10524556", "reactome": "R-CEL-443783", "name": "Interaction of NUMB with L1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10518718", "species_10524552" ], "products": [ "species_10524554" ], "modifiers": [], "additional_components": [ "Q21465", "WBGene00019727", "Q5WRR1", "WBGene00006942", "Q22601", "WBGene00000161", "Q9XTY6", "WBGene00003830", "Q18677", "WBGene00000964", "Q21773", "WBGene00000963", "Q01630", "WBGene00006769", "Q22601", "WBGene00000161", "Q9XTY6", "WBGene00003830", "Q18677", "WBGene00000964", "Q21773", "WBGene00000963", "Q01630", "WBGene00006769", "Q21465", "WBGene00019727", "Q5WRR1", "WBGene00006942" ] }, "reaction_10566112": { "compartment": "compartment_7660", "id": "reaction_10566112", "reactome": "R-CEL-8864278", "name": "AP-2 (TFAP2) transcription factors form homo- and heterodimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10566108" ], "products": [ "species_10566110" ], "modifiers": [], "additional_components": [ "Q09585", "WBGene00019424", "Q19862", "WBGene00009203", "Q19863", "WBGene00009202", "G2HK15", "WBGene00013383", "Q09585", "WBGene00019424", "Q19862", "WBGene00009203", "Q19863", "WBGene00009202", "G2HK15", "WBGene00013383" ] }, "reaction_10566136": { "compartment": "compartment_7660", "id": "reaction_10566136", "reactome": "R-CEL-8864595", "name": "TFAP2B homodimer binds YEATS4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10566132", "species_10566130" ], "products": [ "species_10566134" ], "modifiers": [], "additional_components": [ "Q09585", "WBGene00019424", "Q19862", "WBGene00009203", "Q19863", "WBGene00009202", "G2HK15", "WBGene00013383", "WBGene00001585", "Q21501", "WBGene00001585", "Q09585", "WBGene00019424", "Q19862", "WBGene00009203", "Q19863", "WBGene00009202", "G2HK15", "WBGene00013383" ] }, "reaction_10566124": { "compartment": "compartment_70101", "id": "reaction_10566124", "reactome": "R-CEL-8864577", "name": "TFAP2C translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10566118" ], "products": [ "species_10546739" ], "modifiers": [ [ "species_10566120", "inhibitor" ] ], "additional_components": [ "WBGene00019424", "WBGene00019424", "Q09585", "WBGene00019424", "Q19062", "WBGene00000971" ] }, "reaction_10546753": { "compartment": "compartment_7660", "id": "reaction_10546753", "reactome": "R-CEL-3234094", "name": "SUMOylation of TFAP2C with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546741", "species_10546081" ], "products": [ "species_10546751", "species_10546073" ], "modifiers": [ [ "species_10546081", "catalyst" ] ], "additional_components": [ "Q09585", "WBGene00019424", "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "Q09585", "WBGene00019424", "P55853", "WBGene00004888", "WBGene00006706", "Q95017", "WBGene00006706", "P55853", "WBGene00004888" ] }, "reaction_10566122": { "compartment": "compartment_70101", "id": "reaction_10566122", "reactome": "R-CEL-8864569", "name": "WWOX binds TFAP2C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10532620", "species_10566118" ], "products": [ "species_10566120" ], "modifiers": [], "additional_components": [ "WBGene00000971", "WBGene00019424", "Q09585", "WBGene00019424", "Q19062", "WBGene00000971" ] }, "reaction_10529266": { "compartment": "compartment_70101", "id": "reaction_10529266", "reactome": "R-CEL-927789", "name": "Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10529262", "species_10529242" ], "products": [ "species_10529264" ], "modifiers": [], "additional_components": [ "P91914", "WBGene00004441", "Q19869", "WBGene00004440", "O01868", "WBGene00004436", "P48162", "WBGene00004438", "P52819", "WBGene00004434", "P48158", "WBGene00004435", "Q09533", "WBGene00004421", "P34334", "WBGene00004433", "O02639", "WBGene00004431", "Q95Y90", "WBGene00004420", "O44480", "WBGene00004432", "Q22716", "WBGene00004446", "Q9U332", "WBGene00004445", "Q9XWS4", "WBGene00004444", "P52814", "WBGene00004453", "O45226", "WBGene00004443", "Q21930", "WBGene00004442", "P48166", "WBGene00004454", "Q9BKU5", "WBGene00021350", "P50880", "WBGene00004414", "P61866", "WBGene00004424", "O17570", "WBGene00004452", "Q19162", "WBGene00004423", "Q9U2A8", "WBGene00004456", "Q9N4I4", "WBGene00004412", "O62388", "WBGene00012179", "O01504", "WBGene00016493", "P49181", "WBGene00004450", "P91913", "WBGene00004409", "P49180", "WBGene00004447", "Q93572", "WBGene00004408", "P34662", "WBGene00004449", "Q9XVF7", "WBGene00004413", "O45946", "WBGene00004430", "Q966C6", "WBGene00004419", "Q9BL19", "WBGene00004429", "O01802", "WBGene00004418", "P91374", "WBGene00004427", "P47991", "WBGene00004417", "Q9XVE9", "WBGene00004426", "P49405", "WBGene00004416", "Q27389", "WBGene00004428", "P37165", "WBGene00006725", "P91128", "WBGene00004425", "O02056", "WBGene00004415", "P51403", "WBGene00004471", "Q9NEN6", "WBGene00004475", "Q8WQA8", "WBGene00004489", "Q23312", "WBGene00004476", "O01869", "WBGene00004479", "P49197", "WBGene00004490", "P48156", "WBGene00004477", "Q20206", "WBGene00004480", "Q19877", "WBGene00004492", "Q20228", "WBGene00004478", "P49196", "WBGene00004481", "Q1XFY9", "WBGene00004493", "P46769", "WBGene00004469", "P51404", "WBGene00004482", "P52821", "WBGene00004494", "Q9TXP0", "WBGene00004496", "P48150", "WBGene00004483", "O45499", "WBGene00004495", "Q9N3X2", "WBGene00004473", "Q9XVP0", "WBGene00004484", "Q95Y04", "WBGene00004497", "Q22054", "WBGene00004485", "P90983", "WBGene00004498", "O01692", "WBGene00004486", "P48152", "WBGene00004472", "O18240", "WBGene00004487", "O18650", "WBGene00004488", "P48154", "WBGene00004470", "O17218", "WBGene00004491", "P49041", "WBGene00004474", "O45622", "WBGene00010405", "species_29420", "A0A486WX07", "WBGene00002066", "Q9U302", "WBGene00003902", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "O16520", "WBGene00020269", "WBGene00004880", "O76512", "WBGene00004880", "P91914", "WBGene00004441", "Q19869", "WBGene00004440", "O01868", "WBGene00004436", "P48162", "WBGene00004438", "P52819", "WBGene00004434", "P48158", "WBGene00004435", "Q09533", "WBGene00004421", "P34334", "WBGene00004433", "O02639", "WBGene00004431", "Q95Y90", "WBGene00004420", "O44480", "WBGene00004432", "Q22716", "WBGene00004446", "Q9U332", "WBGene00004445", "Q9XWS4", "WBGene00004444", "P52814", "WBGene00004453", "O45226", "WBGene00004443", "Q21930", "WBGene00004442", "P48166", "WBGene00004454", "Q9BKU5", "WBGene00021350", "P50880", "WBGene00004414", "P61866", "WBGene00004424", "O17570", "WBGene00004452", "Q19162", "WBGene00004423", "Q9U2A8", "WBGene00004456", "Q9N4I4", "WBGene00004412", "O62388", "WBGene00012179", "O01504", "WBGene00016493", "P49181", "WBGene00004450", "P91913", "WBGene00004409", "P49180", "WBGene00004447", "Q93572", "WBGene00004408", "P34662", "WBGene00004449", "Q9XVF7", "WBGene00004413", "O45946", "WBGene00004430", "Q966C6", "WBGene00004419", "Q9BL19", "WBGene00004429", "O01802", "WBGene00004418", "P91374", "WBGene00004427", "P47991", "WBGene00004417", "Q9XVE9", "WBGene00004426", "P49405", "WBGene00004416", "Q27389", "WBGene00004428", "P37165", "WBGene00006725", "P91128", "WBGene00004425", "O02056", "WBGene00004415", "P51403", "WBGene00004471", "Q9NEN6", "WBGene00004475", "Q8WQA8", "WBGene00004489", "Q23312", "WBGene00004476", "O01869", "WBGene00004479", "P49197", "WBGene00004490", "P48156", "WBGene00004477", "Q20206", "WBGene00004480", "Q19877", "WBGene00004492", "Q20228", "WBGene00004478", "P49196", "WBGene00004481", "Q1XFY9", "WBGene00004493", "P46769", "WBGene00004469", "P51404", "WBGene00004482", "P52821", "WBGene00004494", "Q9TXP0", "WBGene00004496", "P48150", "WBGene00004483", "O45499", "WBGene00004495", "Q9N3X2", "WBGene00004473", "Q9XVP0", "WBGene00004484", "Q95Y04", "WBGene00004497", "Q22054", "WBGene00004485", "P90983", "WBGene00004498", "O01692", "WBGene00004486", "P48152", "WBGene00004472", "O18240", "WBGene00004487", "O18650", "WBGene00004488", "P48154", "WBGene00004470", "O17218", "WBGene00004491", "P49041", "WBGene00004474", "O45622", "WBGene00010405", "species_29420", "A0A486WX07", "WBGene00002066", "Q9U302", "WBGene00003902", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "O16520", "WBGene00020269" ] }, "reaction_10508129": { "compartment": "compartment_7660", "id": "reaction_10508129", "reactome": "R-CEL-77068", "name": "Activation of GT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508127" ], "products": [ "species_10508127" ], "modifiers": [], "additional_components": [ "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q17607", "WBGene00000466", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q17607", "WBGene00000466" ] }, "reaction_10508162": { "compartment": "compartment_7660", "id": "reaction_10508162", "reactome": "R-CEL-77078", "name": "Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508155" ], "products": [ "species_113550", "species_10508159" ], "modifiers": [ [ "species_10508155", "catalyst" ] ], "additional_components": [ "Q21338", "WBGene00005015", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q17607", "WBGene00000466", "Q9XVS1", "WBGene00006447", "Q21338", "WBGene00005015", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q17607", "WBGene00000466", "Q9XVS1", "WBGene00006447", "Q21338", "WBGene00005015", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q17607", "WBGene00000466", "Q9XVS1", "WBGene00006447" ] }, "reaction_10508178": { "compartment": "compartment_7660", "id": "reaction_10508178", "reactome": "R-CEL-77085", "name": "Dissociation of transcript with 5'-GMP from GT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508171" ], "products": [ "species_10508176" ], "modifiers": [], "additional_components": [ "Q21338", "WBGene00005015", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q17607", "WBGene00000466", "Q9XVS1", "WBGene00006447", "Q21338", "WBGene00005015", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q17607", "WBGene00000466", "Q9XVS1", "WBGene00006447" ] }, "reaction_10508133": { "compartment": "compartment_7660", "id": "reaction_10508133", "reactome": "R-CEL-77069", "name": "RNA Polymerase II CTD (phosphorylated) binds to CE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508125", "species_10508131" ], "products": [ "species_10508127" ], "modifiers": [], "additional_components": [ "WBGene00000466", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q17607", "WBGene00000466" ] }, "reaction_10508183": { "compartment": "compartment_7660", "id": "reaction_10508183", "reactome": "R-CEL-77090", "name": "Methylation of GMP-cap by RNA Methyltransferase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10508176" ], "products": [ "species_77502", "species_10506316", "species_10504425", "species_10508149", "species_10508180" ], "modifiers": [ [ "species_10508176", "catalyst" ] ], "additional_components": [ "Q21338", "WBGene00005015", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q17607", "WBGene00000466", "Q9XVS1", "WBGene00006447", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "WBGene00005015", "Q17607", "WBGene00000466", "Q9XVS1", "WBGene00006447", "Q21338", "WBGene00005015", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q17607", "WBGene00000466", "Q9XVS1", "WBGene00006447" ] }, "reaction_10508169": { "compartment": "compartment_7660", "id": "reaction_10508169", "reactome": "R-CEL-77081", "name": "Formation of the CE:GMP intermediate complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508159", "species_113571" ], "products": [ "species_10508166", "species_111349" ], "modifiers": [ [ "species_10508159", "catalyst" ] ], "additional_components": [ "Q21338", "WBGene00005015", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q17607", "WBGene00000466", "Q9XVS1", "WBGene00006447", "Q21338", "WBGene00005015", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q17607", "WBGene00000466", "Q9XVS1", "WBGene00006447", "species_113578", "Q21338", "WBGene00005015", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q17607", "WBGene00000466", "Q9XVS1", "WBGene00006447" ] }, "reaction_10508185": { "compartment": "compartment_7660", "id": "reaction_10508185", "reactome": "R-CEL-77094", "name": "Formation of cap binding complex (CBC)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10504344", "species_10504339" ], "products": [ "species_10504346" ], "modifiers": [], "additional_components": [ "WBGene00018156", "WBGene00009141", "Q93594", "WBGene00009141", "O01763", "WBGene00018156" ] }, "reaction_10508153": { "compartment": "compartment_7660", "id": "reaction_10508153", "reactome": "R-CEL-77073", "name": "SPT5 subunit of Pol II binds the RNA triphosphatase (RTP)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508143", "species_10508127", "species_10508149" ], "products": [ "species_10508151" ], "modifiers": [], "additional_components": [ "WBGene00006447", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q17607", "WBGene00000466", "WBGene00005015", "Q21338", "WBGene00005015", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q17607", "WBGene00000466", "Q9XVS1", "WBGene00006447" ] }, "reaction_10508187": { "compartment": "compartment_7660", "id": "reaction_10508187", "reactome": "R-CEL-77095", "name": "Recognition and binding of the mRNA cap by the cap-binding complex ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10504346", "species_10504425" ], "products": [ "species_10504427" ], "modifiers": [], "additional_components": [ "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q93594", "WBGene00009141", "O01763", "WBGene00018156" ] }, "reaction_10508157": { "compartment": "compartment_7660", "id": "reaction_10508157", "reactome": "R-CEL-77077", "name": "Capping complex formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508151", "species_72084", "species_29428" ], "products": [ "species_10508155" ], "modifiers": [], "additional_components": [ "Q21338", "WBGene00005015", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q17607", "WBGene00000466", "Q9XVS1", "WBGene00006447", "Q21338", "WBGene00005015", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q17607", "WBGene00000466", "Q9XVS1", "WBGene00006447" ] }, "reaction_10508174": { "compartment": "compartment_7660", "id": "reaction_10508174", "reactome": "R-CEL-77083", "name": "Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508166" ], "products": [ "species_10508171" ], "modifiers": [ [ "species_10508166", "catalyst" ] ], "additional_components": [ "Q21338", "WBGene00005015", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q17607", "WBGene00000466", "Q9XVS1", "WBGene00006447", "species_113578", "Q21338", "WBGene00005015", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q17607", "WBGene00000466", "Q9XVS1", "WBGene00006447", "Q21338", "WBGene00005015", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q17607", "WBGene00000466", "Q9XVS1", "WBGene00006447", "species_113578" ] }, "reaction_10508321": { "compartment": "compartment_7660", "id": "reaction_10508321", "reactome": "R-CEL-77586", "name": "Cleavage of the 3'-end of Replication Dependent Histone Pre-mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508315" ], "products": [ "species_10508319", "species_10508313" ], "modifiers": [], "additional_components": [ "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "Q09599", "WBGene00000411", "Q20709", "WBGene00018740", "V6CKC3", "WBGene00021689", "Q9N4G9", "WBGene00004920", "Q7YWY5", "WBGene00010619", "Q9GYQ8", "WBGene00016791", "Q9XTU6", "WBGene00004919", "P91918", "WBGene00004915", "Q17348", "WBGene00004914", "P34659", "WBGene00004918", "Q93594", "WBGene00009141", "Q09599", "WBGene00000411", "O01763", "WBGene00018156", "Q20709", "WBGene00018740", "V6CKC3", "WBGene00021689", "Q9N4G9", "WBGene00004920", "Q7YWY5", "WBGene00010619", "Q9GYQ8", "WBGene00016791", "Q9XTU6", "WBGene00004919", "P91918", "WBGene00004915", "Q17348", "WBGene00004914", "P34659", "WBGene00004918" ] }, "reaction_10508283": { "compartment": "compartment_7660", "id": "reaction_10508283", "reactome": "R-CEL-77584", "name": "Binding of SLBP to Replication-Dependent Histone Pre-mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508279", "species_10508274" ], "products": [ "species_10508281" ], "modifiers": [], "additional_components": [ "WBGene00000411", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "Q09599", "WBGene00000411" ] }, "reaction_10508317": { "compartment": "compartment_7660", "id": "reaction_10508317", "reactome": "R-CEL-77585", "name": "Recruitment of U7 snRNP:ZFP100 complex to the SLBP Bound Pre-mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508313", "species_10508281" ], "products": [ "species_10508315" ], "modifiers": [], "additional_components": [ "Q20709", "WBGene00018740", "V6CKC3", "WBGene00021689", "Q9N4G9", "WBGene00004920", "Q7YWY5", "WBGene00010619", "Q9GYQ8", "WBGene00016791", "Q9XTU6", "WBGene00004919", "P91918", "WBGene00004915", "Q17348", "WBGene00004914", "P34659", "WBGene00004918", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "Q09599", "WBGene00000411", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "Q09599", "WBGene00000411", "Q20709", "WBGene00018740", "V6CKC3", "WBGene00021689", "Q9N4G9", "WBGene00004920", "Q7YWY5", "WBGene00010619", "Q9GYQ8", "WBGene00016791", "Q9XTU6", "WBGene00004919", "P91918", "WBGene00004915", "Q17348", "WBGene00004914", "P34659", "WBGene00004918" ] }, "reaction_10508337": { "compartment": "compartment_7660", "id": "reaction_10508337", "reactome": "R-CEL-77591", "name": "Binding of Cleavage factors and Poly(A)Polymerase to the CstF:CPSF:Pre-mRNA Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10505197", "species_10505213", "species_10508331", "species_10505225", "species_10505192" ], "products": [ "species_10508335" ], "modifiers": [], "additional_components": [ "WBGene00003904", "Q93716", "WBGene00009668", "C1P629", "WBGene00008362", "O45577", "WBGene00000774", "Q19864", "WBGene00000773", "Q19866", "WBGene00006307", "Q95PY8", "WBGene00013460", "U4PCM1", "WBGene00011051", "Q9N4C2", "WBGene00022301", "Q7YTG9", "WBGene00044329", "O17403", "WBGene00017313", "O16929", "WBGene00017797", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "P52874", "WBGene00010304", "Q09345", "WBGene00020092", "Q09995", "WBGene00011791", "Q9U2P3", "WBGene00012528", "G5EBX5", "WBGene00009658", "Q09995", "WBGene00011791", "Q9U2P3", "WBGene00012528", "G5EBX5", "WBGene00009658", "P52874", "WBGene00010304", "Q09345", "WBGene00020092", "O45577", "WBGene00000774", "Q19864", "WBGene00000773", "Q19866", "WBGene00006307", "Q95PY8", "WBGene00013460", "U4PCM1", "WBGene00011051", "Q9N4C2", "WBGene00022301", "Q7YTG9", "WBGene00044329", "O17403", "WBGene00017313", "O16929", "WBGene00017797", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "Q93716", "WBGene00009668", "C1P629", "WBGene00008362", "Q93233", "WBGene00003904" ] }, "reaction_10508341": { "compartment": "compartment_7660", "id": "reaction_10508341", "reactome": "R-CEL-77592", "name": "Cleavage of Intronless Pre-mRNA at 3'-end", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508335" ], "products": [ "species_10505213", "species_10505225", "species_10505175", "species_112165", "species_10508339" ], "modifiers": [], "additional_components": [ "Q09995", "WBGene00011791", "Q9U2P3", "WBGene00012528", "G5EBX5", "WBGene00009658", "P52874", "WBGene00010304", "Q09345", "WBGene00020092", "O45577", "WBGene00000774", "Q19864", "WBGene00000773", "Q19866", "WBGene00006307", "Q95PY8", "WBGene00013460", "U4PCM1", "WBGene00011051", "Q9N4C2", "WBGene00022301", "Q7YTG9", "WBGene00044329", "O17403", "WBGene00017313", "O16929", "WBGene00017797", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "Q93716", "WBGene00009668", "C1P629", "WBGene00008362", "Q93233", "WBGene00003904", "Q93716", "WBGene00009668", "C1P629", "WBGene00008362", "P52874", "WBGene00010304", "Q09345", "WBGene00020092", "O45577", "WBGene00000774", "Q19864", "WBGene00000773", "Q19866", "WBGene00006307", "Q93594", "WBGene00009141", "Q95PY8", "WBGene00013460", "U4PCM1", "WBGene00011051", "Q9N4C2", "WBGene00022301", "Q7YTG9", "WBGene00044329", "O17403", "WBGene00017313", "O16929", "WBGene00017797", "Q09995", "WBGene00011791", "Q9U2P3", "WBGene00012528", "G5EBX5", "WBGene00009658", "O01763", "WBGene00018156", "Q93233", "WBGene00003904" ] }, "reaction_10508329": { "compartment": "compartment_7660", "id": "reaction_10508329", "reactome": "R-CEL-77589", "name": "Recognition of AAUAAA sequence by CPSF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508325", "species_10505156" ], "products": [ "species_10508327" ], "modifiers": [], "additional_components": [ "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "Q95PY8", "WBGene00013460", "U4PCM1", "WBGene00011051", "Q9N4C2", "WBGene00022301", "Q7YTG9", "WBGene00044329", "O17403", "WBGene00017313", "O16929", "WBGene00017797", "Q95PY8", "WBGene00013460", "U4PCM1", "WBGene00011051", "Q9N4C2", "WBGene00022301", "Q7YTG9", "WBGene00044329", "O17403", "WBGene00017313", "O16929", "WBGene00017797", "Q93594", "WBGene00009141", "O01763", "WBGene00018156" ] }, "reaction_10508345": { "compartment": "compartment_7660", "id": "reaction_10508345", "reactome": "R-CEL-77593", "name": "Cleavage and polyadenylation of Intronless Pre-mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508335" ], "products": [ "species_10505213", "species_10505197", "species_10505225", "species_10505192", "species_10505175", "species_10508343" ], "modifiers": [], "additional_components": [ "Q09995", "WBGene00011791", "Q9U2P3", "WBGene00012528", "G5EBX5", "WBGene00009658", "P52874", "WBGene00010304", "Q09345", "WBGene00020092", "O45577", "WBGene00000774", "Q19864", "WBGene00000773", "Q19866", "WBGene00006307", "Q95PY8", "WBGene00013460", "U4PCM1", "WBGene00011051", "Q9N4C2", "WBGene00022301", "Q7YTG9", "WBGene00044329", "O17403", "WBGene00017313", "O16929", "WBGene00017797", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "Q93716", "WBGene00009668", "C1P629", "WBGene00008362", "Q93233", "WBGene00003904", "Q93716", "WBGene00009668", "C1P629", "WBGene00008362", "WBGene00003904", "P52874", "WBGene00010304", "Q09345", "WBGene00020092", "Q09995", "WBGene00011791", "Q9U2P3", "WBGene00012528", "G5EBX5", "WBGene00009658", "O45577", "WBGene00000774", "Q19864", "WBGene00000773", "Q19866", "WBGene00006307", "Q95PY8", "WBGene00013460", "U4PCM1", "WBGene00011051", "Q9N4C2", "WBGene00022301", "Q7YTG9", "WBGene00044329", "O17403", "WBGene00017313", "O16929", "WBGene00017797", "Q93594", "WBGene00009141", "O01763", "WBGene00018156" ] }, "reaction_10508333": { "compartment": "compartment_7660", "id": "reaction_10508333", "reactome": "R-CEL-77590", "name": "Recruitment of CstF to the CPSF Bound Pre-mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10505175", "species_10508327" ], "products": [ "species_10508331" ], "modifiers": [], "additional_components": [ "O45577", "WBGene00000774", "Q19864", "WBGene00000773", "Q19866", "WBGene00006307", "Q95PY8", "WBGene00013460", "U4PCM1", "WBGene00011051", "Q9N4C2", "WBGene00022301", "Q7YTG9", "WBGene00044329", "O17403", "WBGene00017313", "O16929", "WBGene00017797", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "O45577", "WBGene00000774", "Q19864", "WBGene00000773", "Q19866", "WBGene00006307", "Q95PY8", "WBGene00013460", "U4PCM1", "WBGene00011051", "Q9N4C2", "WBGene00022301", "Q7YTG9", "WBGene00044329", "O17403", "WBGene00017313", "O16929", "WBGene00017797", "Q93594", "WBGene00009141", "O01763", "WBGene00018156" ] }, "reaction_10508842": { "compartment": "compartment_7660", "id": "reaction_10508842", "reactome": "R-CEL-111437", "name": "Cleavage of the 3'-end of the Histone Pre-mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508838" ], "products": [ "species_10508313", "species_10508840" ], "modifiers": [], "additional_components": [ "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "Q20709", "WBGene00018740", "V6CKC3", "WBGene00021689", "Q9N4G9", "WBGene00004920", "Q7YWY5", "WBGene00010619", "Q9GYQ8", "WBGene00016791", "Q9XTU6", "WBGene00004919", "P91918", "WBGene00004915", "Q17348", "WBGene00004914", "P34659", "WBGene00004918", "Q20709", "WBGene00018740", "V6CKC3", "WBGene00021689", "Q9N4G9", "WBGene00004920", "Q7YWY5", "WBGene00010619", "Q9GYQ8", "WBGene00016791", "Q9XTU6", "WBGene00004919", "P91918", "WBGene00004915", "Q17348", "WBGene00004914", "P34659", "WBGene00004918", "Q93594", "WBGene00009141", "O01763", "WBGene00018156" ] }, "reaction_10508844": { "compartment": "compartment_7660", "id": "reaction_10508844", "reactome": "R-CEL-111438", "name": "Recruitment of U7 snRNP:ZFP100 complex to the Histone Pre-mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508313", "species_10508274" ], "products": [ "species_10508838" ], "modifiers": [], "additional_components": [ "Q20709", "WBGene00018740", "V6CKC3", "WBGene00021689", "Q9N4G9", "WBGene00004920", "Q7YWY5", "WBGene00010619", "Q9GYQ8", "WBGene00016791", "Q9XTU6", "WBGene00004919", "P91918", "WBGene00004915", "Q17348", "WBGene00004914", "P34659", "WBGene00004918", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "Q20709", "WBGene00018740", "V6CKC3", "WBGene00021689", "Q9N4G9", "WBGene00004920", "Q7YWY5", "WBGene00010619", "Q9GYQ8", "WBGene00016791", "Q9XTU6", "WBGene00004919", "P91918", "WBGene00004915", "Q17348", "WBGene00004914", "P34659", "WBGene00004918" ] }, "reaction_10527075": { "compartment": "compartment_70101", "id": "reaction_10527075", "reactome": "R-CEL-482788", "name": "p-S54,92,203-BRF1 binds 14-3-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10525899", "species_10507065" ], "products": [ "species_10527073" ], "modifiers": [], "additional_components": [ "G5EC86", "WBGene00003864", "Q09436", "WBGene00003231", "Q9XUB2", "WBGene00003230", "G5ECB9", "WBGene00003228", "Q20155", "WBGene00009532", "Q9XV46", "WBGene00003388", "G5EF15", "WBGene00004078", "Q23359", "WBGene00003865", "O02289", "WBGene00011376", "Q94131", "WBGene00004027", "O18251", "WBGene00013319", "Q9U1Y2", "WBGene00013797", "O45289", "WBGene00013797", "Q9U2V1", "WBGene00013797", "O45491", "WBGene00009537", "Q9U2V2", "WBGene00013797", "O45493", "WBGene00013797", "Q9U2V4", "WBGene00013794", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "G5EC86", "WBGene00003864", "Q09436", "WBGene00003231", "Q9XUB2", "WBGene00003230", "G5ECB9", "WBGene00003228", "Q20155", "WBGene00009532", "Q9XV46", "WBGene00003388", "G5EF15", "WBGene00004078", "Q23359", "WBGene00003865", "O02289", "WBGene00011376", "Q94131", "WBGene00004027", "O18251", "WBGene00013319", "Q9U1Y2", "WBGene00013797", "O45289", "WBGene00013797", "Q9U2V1", "WBGene00013797", "O45491", "WBGene00009537", "Q9U2V2", "WBGene00013797", "O45493", "WBGene00013797", "Q9U2V4", "WBGene00013794" ] }, "reaction_10525750": { "compartment": "compartment_70101", "id": "reaction_10525750", "reactome": "R-CEL-450406", "name": "p-S92,203-BRF1 binds 14-3-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10507065", "species_10525746" ], "products": [ "species_10525748" ], "modifiers": [], "additional_components": [ "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "O45491", "WBGene00009537", "Q9U2V2", "WBGene00013797", "O45493", "WBGene00013797", "Q9U2V4", "WBGene00013794", "G5EC86", "WBGene00003864", "Q09436", "WBGene00003231", "Q9XUB2", "WBGene00003230", "G5ECB9", "WBGene00003228", "Q20155", "WBGene00009532", "Q9XV46", "WBGene00003388", "G5EF15", "WBGene00004078", "Q23359", "WBGene00003865", "O02289", "WBGene00011376", "Q94131", "WBGene00004027", "O18251", "WBGene00013319", "Q9U1Y2", "WBGene00013797", "O45289", "WBGene00013797", "Q9U2V1", "WBGene00013797", "O45491", "WBGene00009537", "Q9U2V2", "WBGene00013797", "O45493", "WBGene00013797", "Q9U2V4", "WBGene00013794", "G5EC86", "WBGene00003864", "Q09436", "WBGene00003231", "Q9XUB2", "WBGene00003230", "G5ECB9", "WBGene00003228", "Q20155", "WBGene00009532", "Q9XV46", "WBGene00003388", "G5EF15", "WBGene00004078", "Q23359", "WBGene00003865", "O02289", "WBGene00011376", "Q94131", "WBGene00004027", "O18251", "WBGene00013319", "Q9U1Y2", "WBGene00013797", "O45289", "WBGene00013797", "Q9U2V1", "WBGene00013797", "P41932", "WBGene00003920", "Q20655", "WBGene00001502" ] }, "reaction_10525911": { "compartment": "compartment_70101", "id": "reaction_10525911", "reactome": "R-CEL-450488", "name": "BRF1 Complex recruits RNA degradation activities", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10525823", "species_10523562", "species_10523671", "species_10525907", "species_10523569" ], "products": [ "species_10525909" ], "modifiers": [], "additional_components": [ "O18251", "WBGene00013319", "O45289", "WBGene00013797", "O45491", "WBGene00009537", "O45493", "WBGene00013797", "Q09436", "WBGene00003231", "Q20155", "WBGene00009532", "Q23359", "WBGene00003865", "Q94131", "WBGene00004027", "Q9U1Y2", "WBGene00013797", "Q9U2V1", "WBGene00013797", "Q9U2V2", "WBGene00013797", "Q9U2V4", "WBGene00013794", "G5EC86", "WBGene00003864", "Q9XUB2", "WBGene00003230", "G5ECB9", "WBGene00003228", "Q9XV46", "WBGene00003388", "G5EF15", "WBGene00004078", "O02289", "WBGene00011376", "WBGene00021929", "Q95XD0", "WBGene00022232", "G5EDS8", "WBGene00009289", "Q95QG7", "WBGene00018305", "Q9N4P9", "WBGene00000202", "G5EG59", "WBGene00000798", "Q17533", "WBGene00007201", "Q20128", "WBGene00018154", "Q9XXD2", "WBGene00012966", "Q17632", "WBGene00001001", "Q93830", "WBGene00010325", "WBGene00012730", "WBGene00003582", "O62255", "WBGene00003582", "Q9BHK7", "WBGene00012730", "Q95XD0", "WBGene00022232", "G5EDS8", "WBGene00009289", "Q95QG7", "WBGene00018305", "Q9N4P9", "WBGene00000202", "G5EG59", "WBGene00000798", "Q17533", "WBGene00007201", "Q20128", "WBGene00018154", "Q9XXD2", "WBGene00012966", "Q17632", "WBGene00001001", "Q93830", "WBGene00010325", "Q9N363", "WBGene00021929", "O18251", "WBGene00013319", "O45289", "WBGene00013797", "O45491", "WBGene00009537", "O45493", "WBGene00013797", "Q09436", "WBGene00003231", "Q20155", "WBGene00009532", "Q23359", "WBGene00003865", "Q94131", "WBGene00004027", "Q9U1Y2", "WBGene00013797", "Q9U2V1", "WBGene00013797", "Q9U2V2", "WBGene00013797", "Q9U2V4", "WBGene00013794", "G5EC86", "WBGene00003864", "Q9XUB2", "WBGene00003230", "G5ECB9", "WBGene00003228", "Q9XV46", "WBGene00003388", "G5EF15", "WBGene00004078", "O02289", "WBGene00011376" ] }, "reaction_10525914": { "compartment": "compartment_70101", "id": "reaction_10525914", "reactome": "R-CEL-450490", "name": "Protein Kinase B/Akt phosphorylates BRF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10525823", "species_113592" ], "products": [ "species_29370", "species_10525746" ], "modifiers": [ [ "species_10513843", "catalyst" ] ], "additional_components": [ "O18251", "WBGene00013319", "O45289", "WBGene00013797", "O45491", "WBGene00009537", "O45493", "WBGene00013797", "Q09436", "WBGene00003231", "Q20155", "WBGene00009532", "Q23359", "WBGene00003865", "Q94131", "WBGene00004027", "Q9U1Y2", "WBGene00013797", "Q9U2V1", "WBGene00013797", "Q9U2V2", "WBGene00013797", "Q9U2V4", "WBGene00013794", "G5EC86", "WBGene00003864", "Q9XUB2", "WBGene00003230", "G5ECB9", "WBGene00003228", "Q9XV46", "WBGene00003388", "G5EF15", "WBGene00004078", "O02289", "WBGene00011376", "O45491", "WBGene00009537", "Q9U2V2", "WBGene00013797", "O45493", "WBGene00013797", "Q9U2V4", "WBGene00013794", "G5EC86", "WBGene00003864", "Q09436", "WBGene00003231", "Q9XUB2", "WBGene00003230", "G5ECB9", "WBGene00003228", "Q20155", "WBGene00009532", "Q9XV46", "WBGene00003388", "G5EF15", "WBGene00004078", "Q23359", "WBGene00003865", "O02289", "WBGene00011376", "Q94131", "WBGene00004027", "O18251", "WBGene00013319", "Q9U1Y2", "WBGene00013797", "O45289", "WBGene00013797", "Q9U2V1", "WBGene00013797", "Q9XTG7", "WBGene00000103", "G4S4W1", "WBGene00016980", "Q17941", "WBGene00000102" ] }, "reaction_10525932": { "compartment": "compartment_70101", "id": "reaction_10525932", "reactome": "R-CEL-450517", "name": "Butyrate Response Factor1 (BRF1) binds AU-rich element in 3' UTR of mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_450523", "species_10525821" ], "products": [ "species_10525823" ], "modifiers": [], "additional_components": [ "O18251", "WBGene00013319", "O45289", "WBGene00013797", "O45491", "WBGene00009537", "O45493", "WBGene00013797", "Q09436", "WBGene00003231", "Q20155", "WBGene00009532", "Q23359", "WBGene00003865", "Q94131", "WBGene00004027", "Q9U1Y2", "WBGene00013797", "Q9U2V1", "WBGene00013797", "Q9U2V2", "WBGene00013797", "Q9U2V4", "WBGene00013794", "G5EC86", "WBGene00003864", "Q9XUB2", "WBGene00003230", "G5ECB9", "WBGene00003228", "Q9XV46", "WBGene00003388", "G5EF15", "WBGene00004078", "O02289", "WBGene00011376", "O18251", "WBGene00013319", "O45289", "WBGene00013797", "O45491", "WBGene00009537", "O45493", "WBGene00013797", "Q09436", "WBGene00003231", "Q20155", "WBGene00009532", "Q23359", "WBGene00003865", "Q94131", "WBGene00004027", "Q9U1Y2", "WBGene00013797", "Q9U2V1", "WBGene00013797", "Q9U2V2", "WBGene00013797", "Q9U2V4", "WBGene00013794", "G5EC86", "WBGene00003864", "Q9XUB2", "WBGene00003230", "G5ECB9", "WBGene00003228", "Q9XV46", "WBGene00003388", "G5EF15", "WBGene00004078", "O02289", "WBGene00011376" ] }, "reaction_10525902": { "compartment": "compartment_70101", "id": "reaction_10525902", "reactome": "R-CEL-450474", "name": "MK2 phosphorylates BRF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10525823", "species_113592" ], "products": [ "species_10525899", "species_29370" ], "modifiers": [ [ "species_10512640", "catalyst" ] ], "additional_components": [ "O18251", "WBGene00013319", "O45289", "WBGene00013797", "O45491", "WBGene00009537", "O45493", "WBGene00013797", "Q09436", "WBGene00003231", "Q20155", "WBGene00009532", "Q23359", "WBGene00003865", "Q94131", "WBGene00004027", "Q9U1Y2", "WBGene00013797", "Q9U2V1", "WBGene00013797", "Q9U2V2", "WBGene00013797", "Q9U2V4", "WBGene00013794", "G5EC86", "WBGene00003864", "Q9XUB2", "WBGene00003230", "G5ECB9", "WBGene00003228", "Q9XV46", "WBGene00003388", "G5EF15", "WBGene00004078", "O02289", "WBGene00011376", "G5EC86", "WBGene00003864", "Q09436", "WBGene00003231", "Q9XUB2", "WBGene00003230", "G5ECB9", "WBGene00003228", "Q20155", "WBGene00009532", "Q9XV46", "WBGene00003388", "G5EF15", "WBGene00004078", "Q23359", "WBGene00003865", "O02289", "WBGene00011376", "Q94131", "WBGene00004027", "O18251", "WBGene00013319", "Q9U1Y2", "WBGene00013797", "O45289", "WBGene00013797", "Q9U2V1", "WBGene00013797", "O45491", "WBGene00009537", "Q9U2V2", "WBGene00013797", "O45493", "WBGene00013797", "Q9U2V4", "WBGene00013794", "Q21360", "WBGene00010681", "Q965G5", "WBGene00007007" ] }, "reaction_10525984": { "compartment": "compartment_70101", "id": "reaction_10525984", "reactome": "R-CEL-450620", "name": "p-S193-KSRP binds 14-3-3zeta in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10525928", "species_10525970" ], "products": [ "species_10525982" ], "modifiers": [], "additional_components": [ "Q17936", "WBGene00007534", "Q23487", "WBGene00022738", "Q9BLA0", "WBGene00016489", "P91393", "WBGene00019692", "Q20655", "WBGene00001502", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "P41932", "WBGene00003920", "P91393", "WBGene00019692", "Q17936", "WBGene00007534", "Q23487", "WBGene00022738", "Q9BLA0", "WBGene00016489" ] }, "reaction_10525783": { "compartment": "compartment_70101", "id": "reaction_10525783", "reactome": "R-CEL-450422", "name": "KSRP recruits RNA degradation activities", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10525774", "species_10523671", "species_10525779", "species_10523569" ], "products": [ "species_10525781" ], "modifiers": [], "additional_components": [ "Q17936", "WBGene00007534", "Q23487", "WBGene00022738", "Q9BLA0", "WBGene00016489", "P91393", "WBGene00019692", "Q95XD0", "WBGene00022232", "G5EDS8", "WBGene00009289", "Q95QG7", "WBGene00018305", "Q9N4P9", "WBGene00000202", "G5EG59", "WBGene00000798", "Q17533", "WBGene00007201", "Q20128", "WBGene00018154", "Q9XXD2", "WBGene00012966", "Q17632", "WBGene00001001", "Q93830", "WBGene00010325", "WBGene00010734", "WBGene00003582", "O62255", "WBGene00003582", "Q21412", "WBGene00010734", "Q95XD0", "WBGene00022232", "G5EDS8", "WBGene00009289", "Q95QG7", "WBGene00018305", "Q9N4P9", "WBGene00000202", "G5EG59", "WBGene00000798", "Q17533", "WBGene00007201", "Q20128", "WBGene00018154", "Q9XXD2", "WBGene00012966", "Q17632", "WBGene00001001", "Q93830", "WBGene00010325", "Q17936", "WBGene00007534", "Q23487", "WBGene00022738", "Q9BLA0", "WBGene00016489", "P91393", "WBGene00019692" ] }, "reaction_10525930": { "compartment": "compartment_70101", "id": "reaction_10525930", "reactome": "R-CEL-450499", "name": "Protein Kinase B (AKT) phosphorylates KSRP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10525772", "species_113592" ], "products": [ "species_29370", "species_10525928" ], "modifiers": [ [ "species_10513843", "catalyst" ] ], "additional_components": [ "Q17936", "WBGene00007534", "Q23487", "WBGene00022738", "Q9BLA0", "WBGene00016489", "P91393", "WBGene00019692", "Q17936", "WBGene00007534", "Q23487", "WBGene00022738", "Q9BLA0", "WBGene00016489", "P91393", "WBGene00019692", "Q9XTG7", "WBGene00000103", "G4S4W1", "WBGene00016980", "Q17941", "WBGene00000102" ] }, "reaction_10525964": { "compartment": "compartment_70101", "id": "reaction_10525964", "reactome": "R-CEL-450592", "name": "KSRP binds AU-rich element in 3' UTR of mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10525772", "species_450386" ], "products": [ "species_10525774" ], "modifiers": [], "additional_components": [ "Q17936", "WBGene00007534", "Q23487", "WBGene00022738", "Q9BLA0", "WBGene00016489", "P91393", "WBGene00019692", "Q17936", "WBGene00007534", "Q23487", "WBGene00022738", "Q9BLA0", "WBGene00016489", "P91393", "WBGene00019692" ] }, "reaction_10513160": { "compartment": "compartment_70101", "id": "reaction_10513160", "reactome": "R-CEL-191784", "name": "snRNA Cap hypermethylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10513152" ], "products": [ "species_10513139" ], "modifiers": [ [ "species_10513157", "catalyst" ] ], "additional_components": [ "G5ED26", "WBGene00020284", "G5EC16", "WBGene00004887", "P34399", "WBGene00017357", "O01871", "WBGene00017002", "Q9N405", "WBGene00004886", "A7LPI7", "WBGene00007702", "Q9XTU6", "WBGene00004919", "P34659", "WBGene00004918", "Q9N4G9", "WBGene00004920", "P91918", "WBGene00004915", "Q10013", "WBGene00004916", "Q18786", "WBGene00004917", "Q17348", "WBGene00004914", "CHEBI:2274", "CHEBI:1604", "G5ED26", "WBGene00020284", "G5EC16", "WBGene00004887", "P34399", "WBGene00017357", "O01871", "WBGene00017002", "Q9N405", "WBGene00004886", "A7LPI7", "WBGene00007702", "Q9XTU6", "WBGene00004919", "P34659", "WBGene00004918", "Q9N4G9", "WBGene00004920", "P91918", "WBGene00004915", "Q10013", "WBGene00004916", "Q18786", "WBGene00004917", "Q17348", "WBGene00004914", "WBGene00011631" ] }, "reaction_10513148": { "compartment": "compartment_70101", "id": "reaction_10513148", "reactome": "R-CEL-191763", "name": "snRNP:Snurportin complex formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10513144", "species_10513139" ], "products": [ "species_10513146" ], "modifiers": [], "additional_components": [ "WBGene00017746", "CHEBI:1604", "G5ED26", "WBGene00020284", "G5EC16", "WBGene00004887", "P34399", "WBGene00017357", "O01871", "WBGene00017002", "Q9N405", "WBGene00004886", "A7LPI7", "WBGene00007702", "Q9XTU6", "WBGene00004919", "P34659", "WBGene00004918", "Q9N4G9", "WBGene00004920", "P91918", "WBGene00004915", "Q10013", "WBGene00004916", "Q18786", "WBGene00004917", "Q17348", "WBGene00004914", "CHEBI:1604", "O17066", "WBGene00017746", "G5ED26", "WBGene00020284", "G5EC16", "WBGene00004887", "P34399", "WBGene00017357", "O01871", "WBGene00017002", "Q9N405", "WBGene00004886", "A7LPI7", "WBGene00007702", "Q9XTU6", "WBGene00004919", "P34659", "WBGene00004918", "Q9N4G9", "WBGene00004920", "P91918", "WBGene00004915", "Q10013", "WBGene00004916", "Q18786", "WBGene00004917", "Q17348", "WBGene00004914" ] }, "reaction_10523617": { "compartment": "compartment_70101", "id": "reaction_10523617", "reactome": "R-CEL-430021", "name": "PAN2-PAN3 complex partially deadenylates mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10523602" ], "products": [ "species_10523590", "species_76577" ], "modifiers": [ [ "species_10523614", "catalyst" ] ], "additional_components": [ "A0A486WX07", "WBGene00002066", "Q20935", "WBGene00018997", "P27639", "WBGene00002083", "Q9BL61", "WBGene00022029", "H2L0A8", "WBGene00019157", "O61955", "WBGene00002061", "Q9U302", "WBGene00003902", "A0A486WX07", "WBGene00002066", "Q20935", "WBGene00018997", "P27639", "WBGene00002083", "Q9BL61", "WBGene00022029", "H2L0A8", "WBGene00019157", "O61955", "WBGene00002061", "Q9U302", "WBGene00003902", "P53015", "WBGene00017951", "P34653", "WBGene00014015" ] }, "reaction_10568671": { "compartment": "compartment_70101", "id": "reaction_10568671", "reactome": "R-CEL-8941312", "name": "ZCCHC6, ZCCHC11 are mRNA uridyltransferases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6782337", "species_10523590" ], "products": [ "species_10568627" ], "modifiers": [ [ "species_10568668", "catalyst" ] ], "additional_components": [ "A0A486WX07", "WBGene00002066", "Q20935", "WBGene00018997", "P27639", "WBGene00002083", "Q9BL61", "WBGene00022029", "H2L0A8", "WBGene00019157", "O61955", "WBGene00002061", "Q9U302", "WBGene00003902", "species_6782337", "A0A486WX07", "WBGene00002066", "Q20935", "WBGene00018997", "P27639", "WBGene00002083", "Q9BL61", "WBGene00022029", "H2L0A8", "WBGene00019157", "O61955", "WBGene00002061", "Q9U302", "WBGene00003902", "Q09409", "WBGene00019629", "O02094", "WBGene00194706", "O44768", "WBGene00003499", "Q20377", "WBGene00194706", "G5EFR3", "WBGene00194706", "L8E6M1", "WBGene00194706", "Q09408", "WBGene00019628" ] }, "reaction_10523600": { "compartment": "compartment_70101", "id": "reaction_10523600", "reactome": "R-CEL-429978", "name": "Lsm1-7 Complex binds deadenylated mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10523548", "species_429974" ], "products": [ "species_10523550" ], "modifiers": [], "additional_components": [ "Q95XN6", "WBGene00003080", "P92022", "WBGene00001808", "Q23543", "WBGene00003081", "Q20229", "WBGene00003076", "Q20374", "WBGene00009661", "Q9U1W8", "WBGene00003077", "Q19952", "WBGene00003078", "O18694", "WBGene00003079", "Q95XN6", "WBGene00003080", "P92022", "WBGene00001808", "Q23543", "WBGene00003081", "Q20229", "WBGene00003076", "Q20374", "WBGene00009661", "Q9U1W8", "WBGene00003077", "Q19952", "WBGene00003078", "O18694", "WBGene00003079" ] }, "reaction_10523584": { "compartment": "compartment_70101", "id": "reaction_10523584", "reactome": "R-CEL-429860", "name": "DCP1-DCP2 complex decaps mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10523550", "species_29356" ], "products": [ "species_430004", "species_10523552" ], "modifiers": [ [ "species_10523581", "catalyst" ] ], "additional_components": [ "Q95XN6", "WBGene00003080", "P92022", "WBGene00001808", "Q23543", "WBGene00003081", "Q20229", "WBGene00003076", "Q20374", "WBGene00009661", "Q9U1W8", "WBGene00003077", "Q19952", "WBGene00003078", "O18694", "WBGene00003079", "Q95XN6", "WBGene00003080", "P92022", "WBGene00001808", "Q23543", "WBGene00003081", "Q20229", "WBGene00003076", "Q20374", "WBGene00009661", "Q9U1W8", "WBGene00003077", "Q19952", "WBGene00003078", "O18694", "WBGene00003079", "O62255", "WBGene00003582", "Q21740", "WBGene00011036", "Q8ITV6", "WBGene00021551", "Q9N363", "WBGene00021929", "Q95YF3", "WBGene00000479" ] }, "reaction_10557208": { "compartment": "compartment_70101", "id": "reaction_10557208", "reactome": "R-CEL-5694126", "name": "NT5C3B hydrolyses 7MGP to 7MG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_430042" ], "products": [ "species_29372", "species_5694090" ], "modifiers": [ [ "species_10557205", "catalyst" ] ], "additional_components": [ "WBGene00017775" ] }, "reaction_10523598": { "compartment": "compartment_70101", "id": "reaction_10523598", "reactome": "R-CEL-429961", "name": "DCPS scavenges the 7-methylguanosine cap of mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_429926" ], "products": [ "species_430042", "species_429925" ], "modifiers": [ [ "species_10523595", "catalyst" ] ], "additional_components": [ "WBGene00000940" ] }, "reaction_10523695": { "compartment": "compartment_70101", "id": "reaction_10523695", "reactome": "R-CEL-430028", "name": "Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_429974" ], "products": [ "species_109402", "species_113578", "species_109395", "species_429926", "species_76577" ], "modifiers": [ [ "species_10523692", "catalyst" ] ], "additional_components": [ "Q9BKR2", "WBGene00021613", "A5Z2V7", "WBGene00008533", "Q19103", "WBGene00008502", "Q95XD0", "WBGene00022232", "G5EDS8", "WBGene00009289", "Q95QG7", "WBGene00018305", "Q9N4P9", "WBGene00000202", "G5EG59", "WBGene00000798", "Q17533", "WBGene00007201", "Q20128", "WBGene00018154", "Q9XXD2", "WBGene00012966", "Q17632", "WBGene00001001", "Q93830", "WBGene00010325", "P90922", "WBGene00010622" ] }, "reaction_10567172": { "compartment": "compartment_70101", "id": "reaction_10567172", "reactome": "R-CEL-8874082", "name": "MET phosphorylates PTK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10567169" ], "products": [ "species_29370", "species_10567156" ], "modifiers": [ [ "species_10567169", "catalyst" ] ], "additional_components": [ "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q9XVQ7", "WBGene00008711", "Q95YD4", "WBGene00002213", "Q95YD4", "WBGene00002213", "Q9XVQ7", "WBGene00008711", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q9XVQ7", "WBGene00008711", "Q95YD4", "WBGene00002213" ] }, "reaction_10567165": { "compartment": "compartment_70101", "id": "reaction_10567165", "reactome": "R-CEL-8874080", "name": "SRC phosphorylates PTK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10567156" ], "products": [ "species_10567162", "species_29370" ], "modifiers": [ [ "species_10567156", "catalyst" ] ], "additional_components": [ "Q95YD4", "WBGene00002213", "Q9XVQ7", "WBGene00008711", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q9XVQ7", "WBGene00008711", "Q95YD4", "WBGene00002213", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q95YD4", "WBGene00002213", "Q9XVQ7", "WBGene00008711", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635" ] }, "reaction_10548900": { "compartment": "compartment_876", "id": "reaction_10548900", "reactome": "R-CEL-3965444", "name": "WNT:FZD complex promotes G-protein nucleotide exchange", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10548893" ], "products": [ "species_29420", "species_10548897" ], "modifiers": [ [ "species_10548893", "catalyst" ] ], "additional_components": [ "Q9N532", "WBGene00003238", "G5EDV1", "WBGene00003006", "A0A0K3AWM6", "T23D8.1b", "G5ECQ2", "WBGene00000478", "P51875", "WBGene00001648", "Q21917", "WBGene00001669", "P91907", "WBGene00001677", "Q93743", "WBGene00001668", "Q20907", "WBGene00001670", "O76584", "WBGene00001673", "Q9BIG2", "WBGene00001676", "Q20910", "WBGene00001671", "species_29420", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "Q9N532", "WBGene00003238", "G5EDV1", "WBGene00003006", "A0A0K3AWM6", "T23D8.1b", "G5ECQ2", "WBGene00000478", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "P51875", "WBGene00001648", "Q21917", "WBGene00001669", "P91907", "WBGene00001677", "Q93743", "WBGene00001668", "Q20907", "WBGene00001670", "O76584", "WBGene00001673", "Q9BIG2", "WBGene00001676", "Q20910", "WBGene00001671", "species_29438", "Q9N532", "WBGene00003238", "G5EDV1", "WBGene00003006", "A0A0K3AWM6", "T23D8.1b", "G5ECQ2", "WBGene00000478", "P51875", "WBGene00001648", "Q21917", "WBGene00001669", "P91907", "WBGene00001677", "Q93743", "WBGene00001668", "Q20907", "WBGene00001670", "O76584", "WBGene00001673", "Q9BIG2", "WBGene00001676", "Q20910", "WBGene00001671", "species_29420", "P17343", "WBGene00001679", "P54406", "WBGene00001681" ] }, "reaction_10549076": { "compartment": "compartment_70101", "id": "reaction_10549076", "reactome": "R-CEL-4332358", "name": "Dissociation of CaM and CAMK2 autophosphorylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10549073" ], "products": [ "species_10549071", "species_29370", "species_10508995" ], "modifiers": [ [ "species_10549073", "catalyst" ] ], "additional_components": [ "species_74016", "Q11083", "WBGene00020378", "P04630", "WBGene00000285", "G5EF37", "WBGene00003934", "A0A2C9C3L3", "WBGene00020378", "Q18136", "WBGene00006861", "Q09665", "WBGene00006583", "O02159", "WBGene00020378", "G5EDZ8", "WBGene00000288", "Q94288", "WBGene00000287", "Q09980", "WBGene00017394", "O16305", "WBGene00000552", "G5EEG0", "WBGene00000286", "O62305", "WBGene00006779", "O62305", "WBGene00006779", "species_74016", "Q11083", "WBGene00020378", "P04630", "WBGene00000285", "G5EF37", "WBGene00003934", "A0A2C9C3L3", "WBGene00020378", "Q18136", "WBGene00006861", "Q09665", "WBGene00006583", "O02159", "WBGene00020378", "G5EDZ8", "WBGene00000288", "Q94288", "WBGene00000287", "Q09980", "WBGene00017394", "O16305", "WBGene00000552", "G5EEG0", "WBGene00000286", "species_74016", "Q11083", "WBGene00020378", "P04630", "WBGene00000285", "G5EF37", "WBGene00003934", "A0A2C9C3L3", "WBGene00020378", "Q18136", "WBGene00006861", "Q09665", "WBGene00006583", "O02159", "WBGene00020378", "G5EDZ8", "WBGene00000288", "Q94288", "WBGene00000287", "Q09980", "WBGene00017394", "O16305", "WBGene00000552", "G5EEG0", "WBGene00000286", "O62305", "WBGene00006779" ] }, "reaction_10548902": { "compartment": "compartment_876", "id": "reaction_10548902", "reactome": "R-CEL-3965447", "name": "G-protein subunits dissociate from WNT:FZD complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10548897" ], "products": [ "species_10509165", "species_10548887", "species_10548880" ], "modifiers": [], "additional_components": [ "Q9N532", "WBGene00003238", "G5EDV1", "WBGene00003006", "A0A0K3AWM6", "T23D8.1b", "G5ECQ2", "WBGene00000478", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "P51875", "WBGene00001648", "Q21917", "WBGene00001669", "P91907", "WBGene00001677", "Q93743", "WBGene00001668", "Q20907", "WBGene00001670", "O76584", "WBGene00001673", "Q9BIG2", "WBGene00001676", "Q20910", "WBGene00001671", "species_29438", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "P51875", "WBGene00001648", "Q21917", "WBGene00001669", "P91907", "WBGene00001677", "Q93743", "WBGene00001668", "Q20907", "WBGene00001670", "O76584", "WBGene00001673", "Q9BIG2", "WBGene00001676", "Q20910", "WBGene00001671", "Q9N532", "WBGene00003238", "G5EDV1", "WBGene00003006", "A0A0K3AWM6", "T23D8.1b", "G5ECQ2", "WBGene00000478" ] }, "reaction_10549082": { "compartment": "compartment_70101", "id": "reaction_10549082", "reactome": "R-CEL-4332359", "name": "Active calmodulin binds CAMK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10523903", "species_10508995" ], "products": [ "species_10549078" ], "modifiers": [ [ "species_10549080", "inhibitor" ] ], "additional_components": [ "O62305", "WBGene00006779", "species_74016", "Q11083", "WBGene00020378", "P04630", "WBGene00000285", "G5EF37", "WBGene00003934", "A0A2C9C3L3", "WBGene00020378", "Q18136", "WBGene00006861", "Q09665", "WBGene00006583", "O02159", "WBGene00020378", "G5EDZ8", "WBGene00000288", "Q94288", "WBGene00000287", "Q09980", "WBGene00017394", "O16305", "WBGene00000552", "G5EEG0", "WBGene00000286", "species_74016", "Q11083", "WBGene00020378", "P04630", "WBGene00000285", "G5EF37", "WBGene00003934", "A0A2C9C3L3", "WBGene00020378", "Q18136", "WBGene00006861", "Q09665", "WBGene00006583", "O02159", "WBGene00020378", "G5EDZ8", "WBGene00000288", "Q94288", "WBGene00000287", "Q09980", "WBGene00017394", "O16305", "WBGene00000552", "G5EEG0", "WBGene00000286", "O62305", "WBGene00006779", "species_74016", "Q11083", "WBGene00020378", "P04630", "WBGene00000285", "G5EF37", "WBGene00003934", "A0A2C9C3L3", "WBGene00020378", "Q18136", "WBGene00006861", "Q09665", "WBGene00006583", "O02159", "WBGene00020378", "G5EDZ8", "WBGene00000288", "Q94288", "WBGene00000287", "Q09980", "WBGene00017394", "O16305", "WBGene00000552", "G5EEG0", "WBGene00000286", "P22981", "WBGene00002335" ] }, "reaction_10549228": { "compartment": "compartment_70101", "id": "reaction_10549228", "reactome": "R-CEL-4551465", "name": "Translocation of NFATC1:CaN:CaM to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10549222" ], "products": [ "species_10549226" ], "modifiers": [], "additional_components": [ "species_74016", "Q11083", "WBGene00020378", "P04630", "WBGene00000285", "G5EF37", "WBGene00003934", "A0A2C9C3L3", "WBGene00020378", "Q18136", "WBGene00006861", "Q09665", "WBGene00006583", "O02159", "WBGene00020378", "G5EDZ8", "WBGene00000288", "Q94288", "WBGene00000287", "Q09980", "WBGene00017394", "O16305", "WBGene00000552", "G5EEG0", "WBGene00000286", "species_216785", "Q0G819", "WBGene00006527", "species_912516", "G5EDN6", "WBGene00000554", "species_912516", "Q0G819", "WBGene00006527", "species_216785", "species_74016", "A0A2C9C3L3", "WBGene00020378", "Q09980", "WBGene00017394", "G5EDZ8", "WBGene00000288", "Q11083", "WBGene00020378", "G5EEG0", "WBGene00000286", "Q18136", "WBGene00006861", "G5EF37", "WBGene00003934", "Q94288", "WBGene00000287", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "P04630", "WBGene00000285", "Q09665", "WBGene00006583", "G5EDN6", "WBGene00000554" ] }, "reaction_10545533": { "compartment": "compartment_70101", "id": "reaction_10545533", "reactome": "R-CEL-2730872", "name": "Activation of Calcineurin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10541838", "species_10508995", "species_74016" ], "products": [ "species_10545507" ], "modifiers": [], "additional_components": [ "G5EDN6", "WBGene00000554", "species_216785", "Q0G819", "WBGene00006527", "species_912516", "species_74016", "Q11083", "WBGene00020378", "P04630", "WBGene00000285", "G5EF37", "WBGene00003934", "A0A2C9C3L3", "WBGene00020378", "Q18136", "WBGene00006861", "Q09665", "WBGene00006583", "O02159", "WBGene00020378", "G5EDZ8", "WBGene00000288", "Q94288", "WBGene00000287", "Q09980", "WBGene00017394", "O16305", "WBGene00000552", "G5EEG0", "WBGene00000286", "species_74016", "Q11083", "WBGene00020378", "P04630", "WBGene00000285", "G5EF37", "WBGene00003934", "A0A2C9C3L3", "WBGene00020378", "Q18136", "WBGene00006861", "Q09665", "WBGene00006583", "O02159", "WBGene00020378", "G5EDZ8", "WBGene00000288", "Q94288", "WBGene00000287", "Q09980", "WBGene00017394", "O16305", "WBGene00000552", "G5EEG0", "WBGene00000286", "species_216785", "Q0G819", "WBGene00006527", "species_912516", "G5EDN6", "WBGene00000554" ] }, "reaction_10549086": { "compartment": "compartment_70101", "id": "reaction_10549086", "reactome": "R-CEL-4332363", "name": "Autophosphorylation and activation of CAMK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10549078" ], "products": [ "species_29370", "species_10549073" ], "modifiers": [ [ "species_10549078", "catalyst" ] ], "additional_components": [ "species_74016", "Q11083", "WBGene00020378", "P04630", "WBGene00000285", "G5EF37", "WBGene00003934", "A0A2C9C3L3", "WBGene00020378", "Q18136", "WBGene00006861", "Q09665", "WBGene00006583", "O02159", "WBGene00020378", "G5EDZ8", "WBGene00000288", "Q94288", "WBGene00000287", "Q09980", "WBGene00017394", "O16305", "WBGene00000552", "G5EEG0", "WBGene00000286", "O62305", "WBGene00006779", "species_74016", "Q11083", "WBGene00020378", "P04630", "WBGene00000285", "G5EF37", "WBGene00003934", "A0A2C9C3L3", "WBGene00020378", "Q18136", "WBGene00006861", "Q09665", "WBGene00006583", "O02159", "WBGene00020378", "G5EDZ8", "WBGene00000288", "Q94288", "WBGene00000287", "Q09980", "WBGene00017394", "O16305", "WBGene00000552", "G5EEG0", "WBGene00000286", "O62305", "WBGene00006779", "species_74016", "Q11083", "WBGene00020378", "P04630", "WBGene00000285", "G5EF37", "WBGene00003934", "A0A2C9C3L3", "WBGene00020378", "Q18136", "WBGene00006861", "Q09665", "WBGene00006583", "O02159", "WBGene00020378", "G5EDZ8", "WBGene00000288", "Q94288", "WBGene00000287", "Q09980", "WBGene00017394", "O16305", "WBGene00000552", "G5EEG0", "WBGene00000286", "O62305", "WBGene00006779" ] }, "reaction_10549150": { "compartment": "compartment_7660", "id": "reaction_10549150", "reactome": "R-CEL-4411383", "name": "NLK phosphorylates TCF/LEF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10549137" ], "products": [ "species_113582", "species_10549147" ], "modifiers": [ [ "species_10549133", "catalyst" ] ], "additional_components": [ "Q10666", "WBGene00004077", "O44326", "WBGene00001979", "Q10666", "WBGene00004077", "O44326", "WBGene00001979", "Q9U9Y8", "WBGene00003048" ] }, "reaction_10549135": { "compartment": "compartment_7660", "id": "reaction_10549135", "reactome": "R-CEL-4411373", "name": "NLK translocates to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10549129" ], "products": [ "species_10549133" ], "modifiers": [], "additional_components": [ "Q9U9Y8", "WBGene00003048", "Q9U9Y8", "WBGene00003048" ] }, "reaction_10508197": { "compartment": "compartment_5460", "id": "reaction_10508197", "reactome": "R-CEL-77254", "name": "(S)-3-Hydroxydodecanoyl-CoA+NAD<=>3-Oxododecanoyl-CoA+NADH+H", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113526", "species_77252" ], "products": [ "species_113529", "species_77253", "species_29362" ], "modifiers": [ [ "species_10508194", "catalyst" ] ], "additional_components": [ "P41938", "WBGene00007129" ] }, "reaction_10508199": { "compartment": "compartment_5460", "id": "reaction_10508199", "reactome": "R-CEL-77256", "name": "2-trans-Dodecenoyl-CoA+H2O<=>(S)-3-Hydroxydodecanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77255", "species_113521" ], "products": [ "species_77252" ], "modifiers": [ [ "species_10503463", "catalyst" ] ], "additional_components": [ "P34559", "WBGene00001155" ] }, "reaction_10508238": { "compartment": "compartment_5460", "id": "reaction_10508238", "reactome": "R-CEL-77309", "name": "3-Oxododecanoyl-CoA+CoA-SH<=>Decanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_77253" ], "products": [ "species_77308", "species_113559" ], "modifiers": [ [ "species_10508211", "catalyst" ] ], "additional_components": [ "P34255", "WBGene00015125", "Q9GYT0", "WBGene00020347" ] }, "reaction_10570192": { "compartment": "compartment_161320", "id": "reaction_10570192", "reactome": "R-CEL-8963864", "name": "CUBN dissociates from 25(OH)D", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10570190" ], "products": [ "species_10570188", "species_350136" ], "modifiers": [], "additional_components": [ "Q93212", "WBGene00004944", "species_8963879", "WBGene00004944" ] }, "reaction_10516418": { "compartment": "compartment_70101", "id": "reaction_10516418", "reactome": "R-CEL-209845", "name": "CYP2R1 25-hydroxylates VD3 to 25(OH)D", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29368", "species_8963870", "species_29364" ], "products": [ "species_8963879", "species_29356", "species_29366" ], "modifiers": [ [ "species_10516415", "catalyst" ] ], "additional_components": [ "WBGene00016768" ] }, "reaction_10516354": { "compartment": "compartment_70616", "id": "reaction_10516354", "reactome": "R-CEL-209765", "name": "CYP24A1 hydroxylates 1,25(OH)2D, inactivating it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_209800", "species_29368", "species_29364" ], "products": [ "species_29356", "species_350159", "species_29366" ], "modifiers": [ [ "species_10516351", "catalyst" ], [ "species_29532", "catalyst" ] ], "additional_components": [ "G5EGT6", "WBGene00010354", "O17851", "WBGene00009226", "O45219", "WBGene00007140", "Q09660", "WBGene00000375", "Q9N525", "WBGene00021412", "Q9N574", "WBGene00021200", "Q9XVA6", "WBGene00008499", "G5EC97", "WBGene00011830" ] }, "reaction_10570196": { "compartment": "compartment_7660", "id": "reaction_10570196", "reactome": "R-CEL-8963915", "name": "1,25(OH)2D binds VDR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10519369", "species_8963912" ], "products": [ "species_10570194" ], "modifiers": [], "additional_components": [ "Q94407", "WBGene00003638", "Q9XYB7", "WBGene00003607", "G5EFF5", "WBGene00000908", "species_8963912", "Q94407", "WBGene00003638", "Q9XYB7", "WBGene00003607", "G5EFF5", "WBGene00000908" ] }, "reaction_10551658": { "compartment": "compartment_7660", "id": "reaction_10551658", "reactome": "R-CEL-5358592", "name": "DNA ligase I ligates single stranded nick in double stranded DNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_5358610" ], "products": [ "species_109966", "species_164121", "species_113541" ], "modifiers": [ [ "species_10502732", "catalyst" ] ], "additional_components": [ "WBGene00002985" ] }, "reaction_10544314": { "compartment": "compartment_876", "id": "reaction_10544314", "reactome": "R-CEL-2465890", "name": "DDR2 binds collagen type I, II, III, V, X fibrils", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10544310", "species_10544308" ], "products": [ "species_10544312" ], "modifiers": [], "additional_components": [ "Q9N4U2", "WBGene00000647", "O76368", "WBGene00000674", "Q09457", "WBGene00000251", "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689", "P17140", "WBGene00002280", "Q95ZV7", "WBGene00017381", "Q95ZV7", "WBGene00017381", "Q9N4U2", "WBGene00000647", "O76368", "WBGene00000674", "Q09457", "WBGene00000251", "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689", "P17140", "WBGene00002280" ] }, "reaction_10543934": { "compartment": "compartment_876", "id": "reaction_10543934", "reactome": "R-CEL-2327738", "name": "DDR1 binds collagen type I, II, III, IV, V, XI fibrils", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10543930", "species_10543928" ], "products": [ "species_10543932" ], "modifiers": [], "additional_components": [ "Q9N4U2", "WBGene00000647", "O76368", "WBGene00000674", "Q09457", "WBGene00000251", "P17140", "WBGene00002280", "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689", "Q95ZV7", "WBGene00017381", "Q95ZV7", "WBGene00017381", "Q9N4U2", "WBGene00000647", "O76368", "WBGene00000674", "Q09457", "WBGene00000251", "P17140", "WBGene00002280", "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689" ] }, "reaction_10508096": { "compartment": "compartment_17960", "id": "reaction_10508096", "reactome": "R-CEL-76466", "name": "CYP4A11 12-hydroxylates DDCX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_33549", "species_113601" ], "products": [ "species_113519", "species_113564", "species_42373" ], "modifiers": [ [ "species_10508093", "catalyst" ] ], "additional_components": [ "Q9N525", "WBGene00021412", "O17851", "WBGene00009226", "Q9N574", "WBGene00021200", "O45219", "WBGene00007140", "G5EC97", "WBGene00011830", "Q9XVA6", "WBGene00008499", "Q09660", "WBGene00000375", "G5EGT6", "WBGene00010354" ] }, "reaction_10516947": { "compartment": "compartment_17960", "id": "reaction_10516947", "reactome": "R-CEL-211904", "name": "CYP4F12 18-hydroxylates ARA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_140356", "species_113601" ], "products": [ "species_113519", "species_113564", "species_352318" ], "modifiers": [ [ "species_10516944", "catalyst" ] ], "additional_components": [ "G5EC97", "WBGene00011830", "O17851", "WBGene00009226", "G5EGT6", "WBGene00010354", "O45219", "WBGene00007140", "Q9N574", "WBGene00021200", "Q09660", "WBGene00000375", "Q9N525", "WBGene00021412", "Q9XVA6", "WBGene00008499" ] }, "reaction_10517062": { "compartment": "compartment_17960", "id": "reaction_10517062", "reactome": "R-CEL-211983", "name": "CYP2J2 oxidises ARA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_140356", "species_113601" ], "products": [ "species_113519", "species_113564", "species_215062" ], "modifiers": [ [ "species_10517059", "catalyst" ] ], "additional_components": [ "CHEBI:34130", "CHEBI:34157", "species_2142739", "CHEBI:34490", "O45659", "WBGene00010589", "O61204", "WBGene00015045", "O61935", "WBGene00020386", "O62377", "WBGene00011699", "O62378", "WBGene00011698", "P90771", "WBGene00007913", "Q20315", "WBGene00018333", "A0A0M7RF98", "WBGene00018264", "Q27465", "WBGene00015135", "G5ECD0", "WBGene00007362", "Q27470", "WBGene00015709", "G5EE22", "WBGene00012448", "Q27471", "WBGene00016092", "H2KY69", "WBGene00015044", "Q27482", "WBGene00016768", "H2KYS3", "WBGene00000905", "Q27499", "WBGene00018334", "O02627", "WBGene00015399", "Q965T7", "WBGene00021710", "O02628", "WBGene00015400", "Q9N4Q4", "WBGene00021168", "O02641", "WBGene00019967", "Q9N5I1", "WBGene00019565", "O16220", "WBGene00016786", "O16362", "WBGene00018413", "O16482", "WBGene00016860", "O16670", "WBGene00018262", "O16671", "WBGene00018261", "O16673", "WBGene00018260", "O44649", "WBGene00019473", "O44650", "WBGene00019472", "O44651", "WBGene00019471", "O44652", "WBGene00019470", "O44655", "WBGene00015040", "O44656", "WBGene00015041", "O44657", "WBGene00015042", "O44658", "WBGene00015043", "O44704", "WBGene00016686", "O44706", "WBGene00016697", "O45364", "WBGene00008829" ] }, "reaction_10516957": { "compartment": "compartment_17960", "id": "reaction_10516957", "reactome": "R-CEL-211924", "name": "CYP4B1 12-hydroxylates ARA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_140356", "species_113601" ], "products": [ "species_113519", "species_113564", "species_215075" ], "modifiers": [ [ "species_10516954", "catalyst" ] ], "additional_components": [ "G5EC97", "WBGene00011830", "G5EGT6", "WBGene00010354", "O17851", "WBGene00009226", "O45219", "WBGene00007140", "Q09660", "WBGene00000375", "Q9N525", "WBGene00021412", "Q9N574", "WBGene00021200", "Q9XVA6", "WBGene00008499" ] }, "reaction_10558194": { "compartment": "compartment_12045", "id": "reaction_10558194", "reactome": "R-CEL-6786239", "name": "CYP4V2 omega-hydroxylates DHA to HDoHE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_6786220", "species_29368", "species_29364" ], "products": [ "species_29356", "species_29366", "species_6786225" ], "modifiers": [ [ "species_10558191", "catalyst" ] ], "additional_components": [ "WBGene00013585" ] }, "reaction_10513355": { "compartment": "compartment_70101", "id": "reaction_10513355", "reactome": "R-CEL-193060", "name": "CYP19A1 hydroxylates ANDST to E1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29368", "species_193079", "species_29364" ], "products": [ "species_29356", "species_193066", "species_29366", "species_29460" ], "modifiers": [ [ "species_10513352", "catalyst" ] ], "additional_components": [ "Q09660", "WBGene00000375", "Q9N525", "WBGene00021412", "Q9N574", "WBGene00021200", "Q9XVA6", "WBGene00008499", "G5EC97", "WBGene00011830", "G5EGT6", "WBGene00010354", "O17851", "WBGene00009226", "O45219", "WBGene00007140" ] }, "reaction_10516928": { "compartment": "compartment_12045", "id": "reaction_10516928", "reactome": "R-CEL-211873", "name": "CYP4F2, 4F3 20-hydroxylate LTB4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_266056", "species_70106", "species_29368", "species_29364" ], "products": [ "species_29356", "species_29366", "species_2161636" ], "modifiers": [ [ "species_10516925", "catalyst" ] ], "additional_components": [ "Q9XVA6", "WBGene00008499", "G5EC97", "WBGene00011830", "G5EGT6", "WBGene00010354", "O17851", "WBGene00009226", "O45219", "WBGene00007140", "Q09660", "WBGene00000375", "Q9N525", "WBGene00021412", "Q9N574", "WBGene00021200" ] }, "reaction_10552597": { "compartment": "compartment_12045", "id": "reaction_10552597", "reactome": "R-CEL-5602295", "name": "CYP4F22 20-hydroxylates TrXA3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_2142713", "species_29368", "species_29364" ], "products": [ "species_5602281", "species_29356", "species_29366" ], "modifiers": [ [ "species_10508091", "catalyst" ] ], "additional_components": [ "O45219", "WBGene00007140", "Q09660", "WBGene00000375", "Q9N525", "WBGene00021412", "Q9N574", "WBGene00021200", "Q9XVA6", "WBGene00008499", "G5EC97", "WBGene00011830", "G5EGT6", "WBGene00010354", "O17851", "WBGene00009226" ] }, "reaction_10516952": { "compartment": "compartment_17960", "id": "reaction_10516952", "reactome": "R-CEL-211919", "name": "CYP4F8 19-hydroxylates PGH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_30138", "species_113601" ], "products": [ "species_113519", "species_113564", "species_215545" ], "modifiers": [ [ "species_10516949", "catalyst" ] ], "additional_components": [ "Q9XVA6", "WBGene00008499", "G5EC97", "WBGene00011830", "G5EGT6", "WBGene00010354", "O17851", "WBGene00009226", "O45219", "WBGene00007140", "Q09660", "WBGene00000375", "Q9N525", "WBGene00021412", "Q9N574", "WBGene00021200" ] }, "reaction_10517164": { "compartment": "compartment_17960", "id": "reaction_10517164", "reactome": "R-CEL-215526", "name": "CYP4F3 20-hydroxylates LTB4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_215557", "species_113601" ], "products": [ "species_113519", "species_113564", "species_571314" ], "modifiers": [ [ "species_10516925", "catalyst" ] ], "additional_components": [ "Q9XVA6", "WBGene00008499", "G5EC97", "WBGene00011830", "G5EGT6", "WBGene00010354", "O17851", "WBGene00009226", "O45219", "WBGene00007140", "Q09660", "WBGene00000375", "Q9N525", "WBGene00021412", "Q9N574", "WBGene00021200" ] }, "reaction_10516959": { "compartment": "compartment_5460", "id": "reaction_10516959", "reactome": "R-CEL-211950", "name": "CYP24A1 24-hydroxylates CTL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113533", "species_113529", "species_215607", "species_113600" ], "products": [ "species_113563", "species_215622", "species_113521" ], "modifiers": [ [ "species_10516351", "catalyst" ] ], "additional_components": [ "G5EGT6", "WBGene00010354", "O17851", "WBGene00009226", "O45219", "WBGene00007140", "Q09660", "WBGene00000375", "Q9N525", "WBGene00021412", "Q9N574", "WBGene00021200", "Q9XVA6", "WBGene00008499", "G5EC97", "WBGene00011830" ] }, "reaction_10507989": { "compartment": "compartment_12045", "id": "reaction_10507989", "reactome": "R-CEL-76456", "name": "O-atom dealkylation of dextromethorphan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_39703", "species_113601" ], "products": [ "species_143501", "species_113519", "species_113564", "species_76455" ], "modifiers": [ [ "species_10507986", "catalyst" ] ], "additional_components": [ "Q965T7", "WBGene00021710", "O16671", "WBGene00018261", "O45659", "WBGene00010589", "Q9N4Q4", "WBGene00021168", "A0A0M7RF98", "WBGene00018264", "O16673", "WBGene00018260", "O61204", "WBGene00015045", "Q9N5I1", "WBGene00019565", "G5ECD0", "WBGene00007362", "O44649", "WBGene00019473", "O61935", "WBGene00020386", "G5EE22", "WBGene00012448", "O44650", "WBGene00019472", "O62377", "WBGene00011699", "H2KY69", "WBGene00015044", "O44651", "WBGene00019471", "O62378", "WBGene00011698", "H2KYS3", "WBGene00000905", "O44652", "WBGene00019470", "P90771", "WBGene00007913", "O02627", "WBGene00015399", "O44655", "WBGene00015040", "Q20315", "WBGene00018333", "O02628", "WBGene00015400", "O44656", "WBGene00015041", "Q27465", "WBGene00015135", "O02641", "WBGene00019967", "O44657", "WBGene00015042", "Q27470", "WBGene00015709", "O16220", "WBGene00016786", "O44658", "WBGene00015043", "Q27471", "WBGene00016092", "O16362", "WBGene00018413", "O44704", "WBGene00016686", "Q27482", "WBGene00016768", "O16482", "WBGene00016860", "O44706", "WBGene00016697", "Q27499", "WBGene00018334", "O16670", "WBGene00018262", "O45364", "WBGene00008829" ] }, "reaction_10517052": { "compartment": "compartment_12045", "id": "reaction_10517052", "reactome": "R-CEL-211966", "name": "CYP2D6 4-hydroxylates debrisoquine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_211993", "species_113601" ], "products": [ "species_113519", "species_113564", "species_211952" ], "modifiers": [ [ "species_10507986", "catalyst" ] ], "additional_components": [ "Q965T7", "WBGene00021710", "O16671", "WBGene00018261", "O45659", "WBGene00010589", "Q9N4Q4", "WBGene00021168", "A0A0M7RF98", "WBGene00018264", "O16673", "WBGene00018260", "O61204", "WBGene00015045", "Q9N5I1", "WBGene00019565", "G5ECD0", "WBGene00007362", "O44649", "WBGene00019473", "O61935", "WBGene00020386", "G5EE22", "WBGene00012448", "O44650", "WBGene00019472", "O62377", "WBGene00011699", "H2KY69", "WBGene00015044", "O44651", "WBGene00019471", "O62378", "WBGene00011698", "H2KYS3", "WBGene00000905", "O44652", "WBGene00019470", "P90771", "WBGene00007913", "O02627", "WBGene00015399", "O44655", "WBGene00015040", "Q20315", "WBGene00018333", "O02628", "WBGene00015400", "O44656", "WBGene00015041", "Q27465", "WBGene00015135", "O02641", "WBGene00019967", "O44657", "WBGene00015042", "Q27470", "WBGene00015709", "O16220", "WBGene00016786", "O44658", "WBGene00015043", "Q27471", "WBGene00016092", "O16362", "WBGene00018413", "O44704", "WBGene00016686", "Q27482", "WBGene00016768", "O16482", "WBGene00016860", "O44706", "WBGene00016697", "Q27499", "WBGene00018334", "O16670", "WBGene00018262", "O45364", "WBGene00008829" ] }, "reaction_10517057": { "compartment": "compartment_17960", "id": "reaction_10517057", "reactome": "R-CEL-211968", "name": "CYP2W1 oxidises INDOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_113601", "species_216547" ], "products": [ "species_113519", "species_113564", "species_216598" ], "modifiers": [ [ "species_10517054", "catalyst" ] ], "additional_components": [ "O44651", "WBGene00019471", "O44652", "WBGene00019470", "O44655", "WBGene00015040", "O44656", "WBGene00015041", "O44657", "WBGene00015042", "O44658", "WBGene00015043", "O44704", "WBGene00016686", "O44706", "WBGene00016697", "O45364", "WBGene00008829", "O45659", "WBGene00010589", "O61204", "WBGene00015045", "O61935", "WBGene00020386", "O62377", "WBGene00011699", "O62378", "WBGene00011698", "P90771", "WBGene00007913", "Q20315", "WBGene00018333", "A0A0M7RF98", "WBGene00018264", "Q27465", "WBGene00015135", "G5ECD0", "WBGene00007362", "Q27470", "WBGene00015709", "G5EE22", "WBGene00012448", "Q27471", "WBGene00016092", "H2KY69", "WBGene00015044", "Q27482", "WBGene00016768", "H2KYS3", "WBGene00000905", "Q27499", "WBGene00018334", "O02627", "WBGene00015399", "Q965T7", "WBGene00021710", "O02628", "WBGene00015400", "Q9N4Q4", "WBGene00021168", "O02641", "WBGene00019967", "Q9N5I1", "WBGene00019565", "O16220", "WBGene00016786", "O16362", "WBGene00018413", "O16482", "WBGene00016860", "O16670", "WBGene00018262", "O16671", "WBGene00018261", "O16673", "WBGene00018260", "O44649", "WBGene00019473", "O44650", "WBGene00019472" ] }, "reaction_10517044": { "compartment": "compartment_17960", "id": "reaction_10517044", "reactome": "R-CEL-211960", "name": "CYP2U1 19-hydroxylates ARA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_140356", "species_113601" ], "products": [ "species_216620", "species_113519", "species_113564" ], "modifiers": [ [ "species_10517041", "catalyst" ] ], "additional_components": [ "A0A0M7RF98", "WBGene00018264", "Q27465", "WBGene00015135", "G5ECD0", "WBGene00007362", "Q27470", "WBGene00015709", "G5EE22", "WBGene00012448", "Q27471", "WBGene00016092", "H2KY69", "WBGene00015044", "Q27482", "WBGene00016768", "H2KYS3", "WBGene00000905", "Q27499", "WBGene00018334", "O02627", "WBGene00015399", "Q965T7", "WBGene00021710", "O02628", "WBGene00015400", "Q9N4Q4", "WBGene00021168", "O02641", "WBGene00019967", "Q9N5I1", "WBGene00019565", "O16220", "WBGene00016786", "O16362", "WBGene00018413", "O16482", "WBGene00016860", "O16670", "WBGene00018262", "O16671", "WBGene00018261", "O16673", "WBGene00018260", "O44649", "WBGene00019473", "O44650", "WBGene00019472", "O44651", "WBGene00019471", "O44652", "WBGene00019470", "O44655", "WBGene00015040", "O44656", "WBGene00015041", "O44657", "WBGene00015042", "O44658", "WBGene00015043", "O44704", "WBGene00016686", "O44706", "WBGene00016697", "O45364", "WBGene00008829", "O45659", "WBGene00010589", "O61204", "WBGene00015045", "O61935", "WBGene00020386", "O62377", "WBGene00011699", "O62378", "WBGene00011698", "P90771", "WBGene00007913", "Q20315", "WBGene00018333" ] }, "reaction_10517049": { "compartment": "compartment_17960", "id": "reaction_10517049", "reactome": "R-CEL-211962", "name": "CYP4F11 16-hydroxylates 3OH-PALM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_216621", "species_113601" ], "products": [ "species_113519", "species_113564", "species_216612" ], "modifiers": [ [ "species_10517046", "catalyst" ] ], "additional_components": [ "G5EGT6", "WBGene00010354", "Q9N574", "WBGene00021200" ] }, "reaction_10545531": { "compartment": "compartment_70101", "id": "reaction_10545531", "reactome": "R-CEL-2730867", "name": "Translocation of CaN:CaM:NFAT to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10545511" ], "products": [ "species_10545529" ], "modifiers": [], "additional_components": [ "species_74016", "Q11083", "WBGene00020378", "P04630", "WBGene00000285", "G5EF37", "WBGene00003934", "A0A2C9C3L3", "WBGene00020378", "Q18136", "WBGene00006861", "Q09665", "WBGene00006583", "O02159", "WBGene00020378", "G5EDZ8", "WBGene00000288", "Q94288", "WBGene00000287", "Q09980", "WBGene00017394", "O16305", "WBGene00000552", "G5EEG0", "WBGene00000286", "species_216785", "Q0G819", "WBGene00006527", "species_912516", "G5EDN6", "WBGene00000554", "species_912516", "Q0G819", "WBGene00006527", "species_216785", "species_74016", "A0A2C9C3L3", "WBGene00020378", "Q09980", "WBGene00017394", "G5EDZ8", "WBGene00000288", "Q11083", "WBGene00020378", "G5EEG0", "WBGene00000286", "Q18136", "WBGene00006861", "G5EF37", "WBGene00003934", "Q94288", "WBGene00000287", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "P04630", "WBGene00000285", "Q09665", "WBGene00006583", "G5EDN6", "WBGene00000554" ] }, "reaction_10544706": { "compartment": "compartment_2514888", "id": "reaction_10544706", "reactome": "R-CEL-2485182", "name": "Gt-GTP dissociates to GNAT1-GTP and GNB1:GNGT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10544704" ], "products": [ "species_10544702", "species_10544695" ], "modifiers": [], "additional_components": [ "Q9BIG2", "WBGene00001676", "P91907", "WBGene00001677", "Q20907", "WBGene00001670", "Q20910", "WBGene00001671", "Q21917", "WBGene00001669", "Q93743", "WBGene00001668", "O76584", "WBGene00001673", "species_29438", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "Q9BIG2", "WBGene00001676", "P91907", "WBGene00001677", "Q20907", "WBGene00001670", "Q20910", "WBGene00001671", "Q21917", "WBGene00001669", "Q93743", "WBGene00001668", "O76584", "WBGene00001673", "species_29438" ] }, "reaction_10544724": { "compartment": "compartment_70101", "id": "reaction_10544724", "reactome": "R-CEL-2514865", "name": "cGMP dissociates from CNG channels", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10506568" ], "products": [ "species_30991", "species_10506566" ], "modifiers": [], "additional_components": [ "G5EEE2", "WBGene00006525", "Q03611", "WBGene00006526", "Q7Z205", "WBGene00000563", "A8WI01", "WBGene00000562", "Q9N4C1", "WBGene00022295", "O61827", "WBGene00000487", "species_30991", "G5EEE2", "WBGene00006525", "Q03611", "WBGene00006526", "Q7Z205", "WBGene00000563", "A8WI01", "WBGene00000562", "Q9N4C1", "WBGene00022295", "O61827", "WBGene00000487" ] }, "reaction_10544727": { "compartment": "compartment_70101", "id": "reaction_10544727", "reactome": "R-CEL-2514867", "name": "cGMP:CNG transports Na+ and Ca2+ into the rod outer segment", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74112", "species_74113" ], "products": [ "species_83910", "species_74016" ], "modifiers": [ [ "species_10506568", "catalyst" ] ], "additional_components": [ "G5EEE2", "WBGene00006525", "Q03611", "WBGene00006526", "Q7Z205", "WBGene00000563", "A8WI01", "WBGene00000562", "Q9N4C1", "WBGene00022295", "O61827", "WBGene00000487", "species_30991" ] }, "reaction_10544802": { "compartment": "compartment_70101", "id": "reaction_10544802", "reactome": "R-CEL-2534087", "name": "NMT1/2 transfer MYS to GNAT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10544792", "species_2534019" ], "products": [ "species_10544691", "species_76194" ], "modifiers": [ [ "species_10544797", "catalyst" ] ], "additional_components": [ "Q20910", "WBGene00001671", "Q21917", "WBGene00001669", "Q93743", "WBGene00001668", "Q9BIG2", "WBGene00001676", "O76584", "WBGene00001673", "P91907", "WBGene00001677", "Q20907", "WBGene00001670", "Q9BIG2", "WBGene00001676", "P91907", "WBGene00001677", "Q20907", "WBGene00001670", "Q20910", "WBGene00001671", "Q21917", "WBGene00001669", "Q93743", "WBGene00001668", "O76584", "WBGene00001673", "WBGene00020549" ] }, "reaction_10544837": { "compartment": "compartment_70101", "id": "reaction_10544837", "reactome": "R-CEL-2534096", "name": "METAP1/2 demethylates GNAT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10544818" ], "products": [ "species_10544792", "species_174390" ], "modifiers": [ [ "species_10544834", "catalyst" ] ], "additional_components": [ "Q9BIG2", "WBGene00001676", "O76584", "WBGene00001673", "P91907", "WBGene00001677", "Q20907", "WBGene00001670", "Q20910", "WBGene00001671", "Q21917", "WBGene00001669", "Q93743", "WBGene00001668", "Q20910", "WBGene00001671", "Q21917", "WBGene00001669", "Q93743", "WBGene00001668", "Q9BIG2", "WBGene00001676", "O76584", "WBGene00001673", "P91907", "WBGene00001677", "Q20907", "WBGene00001670", "species_880069", "H1UBK1", "WBGene00003130", "Q965Y1", "WBGene00003129" ] }, "reaction_10544774": { "compartment": "compartment_2514888", "id": "reaction_10544774", "reactome": "R-CEL-2530501", "name": "FNTA:FNTB transfers FARN to GNGT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10544764", "species_2530486" ], "products": [ "species_111294", "species_10544700" ], "modifiers": [ [ "species_10544771", "catalyst" ] ], "additional_components": [ "WBGene00001681", "WBGene00001681", "Q19752", "WBGene00006465", "O44501", "WBGene00019823" ] }, "reaction_10544918": { "compartment": "compartment_70101", "id": "reaction_10544918", "reactome": "R-CEL-2586748", "name": "GUCA binds Ca2+ to form GUCA:Ca2+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10544904", "species_74016" ], "products": [ "species_10544916" ], "modifiers": [], "additional_components": [ "WBGene00003564", "species_74016", "P36609", "WBGene00003564" ] }, "reaction_10546711": { "compartment": "compartment_70101", "id": "reaction_10546711", "reactome": "R-CEL-3229181", "name": "CALM1:Ca2+ binds CNG channel", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10506566", "species_10508995" ], "products": [ "species_10546709" ], "modifiers": [ [ "species_74016", "catalyst" ] ], "additional_components": [ "G5EEE2", "WBGene00006525", "Q03611", "WBGene00006526", "Q7Z205", "WBGene00000563", "A8WI01", "WBGene00000562", "Q9N4C1", "WBGene00022295", "O61827", "WBGene00000487", "species_74016", "Q11083", "WBGene00020378", "P04630", "WBGene00000285", "G5EF37", "WBGene00003934", "A0A2C9C3L3", "WBGene00020378", "Q18136", "WBGene00006861", "Q09665", "WBGene00006583", "O02159", "WBGene00020378", "G5EDZ8", "WBGene00000288", "Q94288", "WBGene00000287", "Q09980", "WBGene00017394", "O16305", "WBGene00000552", "G5EEG0", "WBGene00000286", "species_74016", "Q11083", "WBGene00020378", "P04630", "WBGene00000285", "G5EF37", "WBGene00003934", "A0A2C9C3L3", "WBGene00020378", "Q18136", "WBGene00006861", "Q09665", "WBGene00006583", "O02159", "WBGene00020378", "G5EDZ8", "WBGene00000288", "Q94288", "WBGene00000287", "Q09980", "WBGene00017394", "O16305", "WBGene00000552", "G5EEG0", "WBGene00000286", "G5EEE2", "WBGene00006525", "Q03611", "WBGene00006526", "Q7Z205", "WBGene00000563", "A8WI01", "WBGene00000562", "Q9N4C1", "WBGene00022295", "O61827", "WBGene00000487" ] }, "reaction_10506570": { "compartment": "compartment_70101", "id": "reaction_10506570", "reactome": "R-CEL-74031", "name": "cGMP binds CNG channel to form cGMP:CNG channel", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30991", "species_10506566" ], "products": [ "species_10506568" ], "modifiers": [], "additional_components": [ "G5EEE2", "WBGene00006525", "Q03611", "WBGene00006526", "Q7Z205", "WBGene00000563", "A8WI01", "WBGene00000562", "Q9N4C1", "WBGene00022295", "O61827", "WBGene00000487", "G5EEE2", "WBGene00006525", "Q03611", "WBGene00006526", "Q7Z205", "WBGene00000563", "A8WI01", "WBGene00000562", "Q9N4C1", "WBGene00022295", "O61827", "WBGene00000487", "species_30991" ] }, "reaction_10544161": { "compartment": "compartment_70101", "id": "reaction_10544161", "reactome": "R-CEL-2404142", "name": "atROL binds RBP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2473616", "species_10506914" ], "products": [ "species_10544159" ], "modifiers": [], "additional_components": [ "O02324", "WBGene00002260", "O01812", "WBGene00002258", "O01814", "WBGene00002257", "O02323", "WBGene00002259", "O02324", "WBGene00002260", "O01812", "WBGene00002258", "O01814", "WBGene00002257", "O02323", "WBGene00002259", "species_5623649" ] }, "reaction_10544130": { "compartment": "compartment_70101", "id": "reaction_10544130", "reactome": "R-CEL-2399913", "name": "atRAL binds to RBP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10530542", "species_975622" ], "products": [ "species_10530546" ], "modifiers": [], "additional_components": [ "O01812", "WBGene00002258", "O01814", "WBGene00002257", "O02323", "WBGene00002259", "O02324", "WBGene00002260", "species_5623648", "O01812", "WBGene00002258", "O01814", "WBGene00002257", "O02323", "WBGene00002259", "O02324", "WBGene00002260" ] }, "reaction_10530532": { "compartment": "compartment_984", "id": "reaction_10530532", "reactome": "R-CEL-975594", "name": "PLB1 hydrolyses RPALM to atROL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_975591" ], "products": [ "species_975590", "species_426576" ], "modifiers": [ [ "species_10530529", "catalyst" ] ], "additional_components": [ "Q8MXQ8", "WBGene00022256", "Q9N2Z4", "WBGene00022256" ] }, "reaction_10530548": { "compartment": "compartment_70101", "id": "reaction_10530548", "reactome": "R-CEL-975633", "name": "atROL binds to RBP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10530542", "species_975590" ], "products": [ "species_10530544" ], "modifiers": [], "additional_components": [ "O01812", "WBGene00002258", "O01814", "WBGene00002257", "O02323", "WBGene00002259", "O02324", "WBGene00002260", "species_5623649", "O01812", "WBGene00002258", "O01814", "WBGene00002257", "O02323", "WBGene00002259", "O02324", "WBGene00002260" ] }, "reaction_10544165": { "compartment": "compartment_70101", "id": "reaction_10544165", "reactome": "R-CEL-2404144", "name": "Parenchymal atROL translocates to HSCs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10544163" ], "products": [ "species_2473616", "species_10506914" ], "modifiers": [], "additional_components": [ "O02324", "WBGene00002260", "O01812", "WBGene00002258", "O01814", "WBGene00002257", "O02323", "WBGene00002259", "species_5623649", "O02324", "WBGene00002260", "O01812", "WBGene00002258", "O01814", "WBGene00002257", "O02323", "WBGene00002259" ] }, "reaction_10530570": { "compartment": "compartment_70101", "id": "reaction_10530570", "reactome": "R-CEL-975635", "name": "BCMO1:Fe2+ cleaves betaC to atRAL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_975643" ], "products": [ "species_975622" ], "modifiers": [ [ "species_10530567", "catalyst" ] ], "additional_components": [ "Q9U2E4", "WBGene00012914", "H2L060", "WBGene00018640", "Q9TXT9", "WBGene00018755", "species_113531" ] }, "reaction_10545931": { "compartment": "compartment_70101", "id": "reaction_10545931", "reactome": "R-CEL-2855252", "name": "AKRs reduce RBP2:atRAL to RBP2:atROL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_10530546" ], "products": [ "species_29366", "species_10530544" ], "modifiers": [ [ "species_10545928", "catalyst" ] ], "additional_components": [ "species_5623648", "O01812", "WBGene00002258", "O01814", "WBGene00002257", "O02323", "WBGene00002259", "O02324", "WBGene00002260", "species_5623649", "O01812", "WBGene00002258", "O01814", "WBGene00002257", "O02323", "WBGene00002259", "O02324", "WBGene00002260", "P91020", "WBGene00016985", "Q18903", "WBGene00016985", "Q23320", "WBGene00016985" ] }, "reaction_10544155": { "compartment": "compartment_984", "id": "reaction_10544155", "reactome": "R-CEL-2404134", "name": "RBP4:atROL binds TTR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10544137", "species_10544151" ], "products": [ "species_10544153" ], "modifiers": [], "additional_components": [ "species_5623649", "G5EEB8", "WBGene00011726", "Q21882", "WBGene00022808", "O44578", "WBGene00022808", "Q21882", "WBGene00022808", "O44578", "WBGene00022808", "species_5623649", "G5EEB8", "WBGene00011726" ] }, "reaction_10545933": { "compartment": "compartment_70101", "id": "reaction_10545933", "reactome": "R-CEL-2855259", "name": "atROL binds RBP1 (parenchymal cell)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2473610", "species_10506914" ], "products": [ "species_10544163" ], "modifiers": [], "additional_components": [ "O02324", "WBGene00002260", "O01812", "WBGene00002258", "O01814", "WBGene00002257", "O02323", "WBGene00002259", "O02324", "WBGene00002260", "O01812", "WBGene00002258", "O01814", "WBGene00002257", "O02323", "WBGene00002259", "species_5623649" ] }, "reaction_10544157": { "compartment": "compartment_984", "id": "reaction_10544157", "reactome": "R-CEL-2404135", "name": "RBP4 binds atROL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10544135", "species_2395761" ], "products": [ "species_10544137" ], "modifiers": [], "additional_components": [ "WBGene00011726", "species_5623649", "G5EEB8", "WBGene00011726" ] }, "reaction_10550030": { "compartment": "compartment_5460", "id": "reaction_10550030", "reactome": "R-CEL-5164399", "name": "BCO2:Fe2+ cleaves betaC to APO10al and bION", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113533", "species_5164389" ], "products": [ "species_5164390", "species_5164383" ], "modifiers": [ [ "species_10550027", "catalyst" ] ], "additional_components": [ "Q9TXT9", "WBGene00018755", "species_113531" ] }, "reaction_10544304": { "compartment": "compartment_70101", "id": "reaction_10544304", "reactome": "R-CEL-2464822", "name": "RDH12 reduces atRAL to atROL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_975622", "species_29364" ], "products": [ "species_2473615", "species_29366" ], "modifiers": [ [ "species_10544301", "catalyst" ] ], "additional_components": [ "WBGene00007780" ] }, "reaction_10506918": { "compartment": "compartment_70101", "id": "reaction_10506918", "reactome": "R-CEL-74843", "name": "atROL binds RBP1 to form RBP1:atROL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10506914", "species_2473604" ], "products": [ "species_10506916" ], "modifiers": [], "additional_components": [ "O02324", "WBGene00002260", "O01812", "WBGene00002258", "O01814", "WBGene00002257", "O02323", "WBGene00002259", "species_5623649", "O02324", "WBGene00002260", "O01812", "WBGene00002258", "O01814", "WBGene00002257", "O02323", "WBGene00002259" ] }, "reaction_10544295": { "compartment": "compartment_70101", "id": "reaction_10544295", "reactome": "R-CEL-2453833", "name": "RPE65 isomero-hydrolyses atREs to 11cROL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_2864099" ], "products": [ "species_30927", "species_2864103", "species_70106" ], "modifiers": [ [ "species_10544287", "catalyst" ], [ "species_10544293", "catalyst" ] ], "additional_components": [ "CHEBI:70762", "species_2534407", "CHEBI:70760", "CHEBI:70761", "CHEBI:16196", "CHEBI:17351", "species_390435", "species_8934421", "H2L060", "WBGene00018640", "Q9TXT9", "WBGene00018755", "Q9U2E4", "WBGene00012914", "WBGene00002039" ] }, "reaction_10544339": { "compartment": "compartment_70101", "id": "reaction_10544339", "reactome": "R-CEL-2465940", "name": "atRAL is reduced to atROL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_975622", "species_29364" ], "products": [ "species_29366", "species_2473607" ], "modifiers": [ [ "species_10544336", "catalyst" ] ], "additional_components": [ "O18030", "WBGene00000968", "Q19843", "WBGene00000992", "Q22392", "WBGene00000982", "A5JYX5", "WBGene00000967" ] }, "reaction_10543792": { "compartment": "compartment_7660", "id": "reaction_10543792", "reactome": "R-CEL-2294600", "name": "CDK1 phosphorylates condensin II subunit NCAPD3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10543756" ], "products": [ "species_113582", "species_10543788" ], "modifiers": [ [ "species_10511241", "catalyst" ] ], "additional_components": [ "P62784", "WBGene00001875", "Q20818", "WBGene00010093", "Q09591", "WBGene00003367", "P34341", "WBGene00016202", "Q20060", "WBGene00004874", "Q95Y84", "WBGene00001833", "Q20818", "WBGene00010093", "Q09591", "WBGene00003367", "Q95Y84", "WBGene00001833", "P34341", "WBGene00016202", "Q20060", "WBGene00004874", "P62784", "WBGene00001875", "O45926", "WBGene00000866", "Q10653", "WBGene00000865", "Q9BLB5", "WBGene00000867", "P34556", "WBGene00000405" ] }, "reaction_10543762": { "compartment": "compartment_7660", "id": "reaction_10543762", "reactome": "R-CEL-2288097", "name": "Condensin II complex binds H4K20me1-containing nucleosomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10543339", "species_10543368" ], "products": [ "species_10543756" ], "modifiers": [ [ "species_10543760", "catalyst" ] ], "additional_components": [ "Q20818", "WBGene00010093", "Q09591", "WBGene00003367", "P34341", "WBGene00016202", "Q20060", "WBGene00004874", "Q95Y84", "WBGene00001833", "P62784", "WBGene00001875", "P62784", "WBGene00001875", "Q20818", "WBGene00010093", "Q09591", "WBGene00003367", "P34341", "WBGene00016202", "Q20060", "WBGene00004874", "Q95Y84", "WBGene00001833", "Q20818", "WBGene00010093", "Q09591", "WBGene00003367", "P34341", "WBGene00016202", "Q20060", "WBGene00004874", "Q95Y84", "WBGene00001833" ] }, "reaction_10543715": { "compartment": "compartment_7660", "id": "reaction_10543715", "reactome": "R-CEL-2245218", "name": "CDK1 phosphorylates PHF8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10543378" ], "products": [ "species_113582", "species_10543368", "species_10543713" ], "modifiers": [ [ "species_10511241", "catalyst" ] ], "additional_components": [ "species_113531", "Q9GYI0", "WBGene00017920", "P62784", "WBGene00001875", "P62784", "WBGene00001875", "species_113531", "Q9GYI0", "WBGene00017920", "O45926", "WBGene00000866", "Q10653", "WBGene00000865", "Q9BLB5", "WBGene00000867", "P34556", "WBGene00000405" ] }, "reaction_10543385": { "compartment": "compartment_7660", "id": "reaction_10543385", "reactome": "R-CEL-2172678", "name": "PHF8 demethylates histone H4K20me1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113671", "species_113685", "species_10543378" ], "products": [ "species_29478", "species_10543382", "species_159942", "species_159939" ], "modifiers": [ [ "species_10543378", "catalyst" ] ], "additional_components": [ "species_113531", "Q9GYI0", "WBGene00017920", "P62784", "WBGene00001875", "species_113531", "Q9GYI0", "WBGene00017920", "P62784", "WBGene00001875", "species_113531", "Q9GYI0", "WBGene00017920", "P62784", "WBGene00001875" ] }, "reaction_10543786": { "compartment": "compartment_7660", "id": "reaction_10543786", "reactome": "R-CEL-2294580", "name": "PLK1 hyperphosphorylates Condensin II complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10543770" ], "products": [ "species_113582", "species_10543783" ], "modifiers": [ [ "species_10543770", "catalyst" ] ], "additional_components": [ "P62784", "WBGene00001875", "Q20818", "WBGene00010093", "Q09591", "WBGene00003367", "Q95Y84", "WBGene00001833", "P34341", "WBGene00016202", "Q20060", "WBGene00004874", "Q9N2L7", "WBGene00004043", "Q20818", "WBGene00010093", "P34341", "WBGene00016202", "Q09591", "WBGene00003367", "Q20060", "WBGene00004874", "Q95Y84", "WBGene00001833", "P62784", "WBGene00001875", "Q9N2L7", "WBGene00004043", "P62784", "WBGene00001875", "Q20818", "WBGene00010093", "Q09591", "WBGene00003367", "Q95Y84", "WBGene00001833", "P34341", "WBGene00016202", "Q20060", "WBGene00004874", "Q9N2L7", "WBGene00004043" ] }, "reaction_10543804": { "compartment": "compartment_7660", "id": "reaction_10543804", "reactome": "R-CEL-2301205", "name": "SETD8 monomethylates histone H4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10543382" ], "products": [ "species_77502", "species_10543378" ], "modifiers": [ [ "species_10543801", "catalyst" ] ], "additional_components": [ "species_113531", "Q9GYI0", "WBGene00017920", "P62784", "WBGene00001875", "species_113531", "Q9GYI0", "WBGene00017920", "P62784", "WBGene00001875", "WBGene00004781" ] }, "reaction_10543790": { "compartment": "compartment_7660", "id": "reaction_10543790", "reactome": "R-CEL-2294590", "name": "PLK1 binds phosphorylated condensin II complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10543788", "species_10509851" ], "products": [ "species_10543770" ], "modifiers": [], "additional_components": [ "Q20818", "WBGene00010093", "Q09591", "WBGene00003367", "Q95Y84", "WBGene00001833", "P34341", "WBGene00016202", "Q20060", "WBGene00004874", "P62784", "WBGene00001875", "WBGene00004043", "P62784", "WBGene00001875", "Q20818", "WBGene00010093", "Q09591", "WBGene00003367", "Q95Y84", "WBGene00001833", "P34341", "WBGene00016202", "Q20060", "WBGene00004874", "Q9N2L7", "WBGene00004043" ] }, "reaction_10543577": { "compartment": "compartment_20699", "id": "reaction_10543577", "reactome": "R-CEL-2214351", "name": "PLK1 phosphorylates GORASP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10543569" ], "products": [ "species_29370", "species_10543574" ], "modifiers": [ [ "species_10543569", "catalyst" ] ], "additional_components": [ "Q9N2L7", "WBGene00004043", "Q19989", "WBGene00018017", "Q9N3Y1", "WBGene00021536", "Q9UAQ6", "WBGene00004266", "species_29438", "Q19989", "WBGene00018017", "Q9N3Y1", "WBGene00021536", "Q9N2L7", "WBGene00004043", "Q9UAQ6", "WBGene00004266", "species_29438", "Q9N2L7", "WBGene00004043", "Q19989", "WBGene00018017", "Q9N3Y1", "WBGene00021536", "Q9UAQ6", "WBGene00004266", "species_29438" ] }, "reaction_10544207": { "compartment": "compartment_20699", "id": "reaction_10544207", "reactome": "R-CEL-2422927", "name": "MAPK3-3 or MAPK1 phosphorylate GORASP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10544192" ], "products": [ "species_29370", "species_10544198" ], "modifiers": [ [ "species_10544204", "catalyst" ] ], "additional_components": [ "Q9N3Y1", "WBGene00021536", "Q21954", "WBGene00020018", "A0A2C9C2Y0", "WBGene00006833", "species_29438", "Q9N3Y1", "WBGene00021536", "Q21954", "WBGene00020018", "A0A2C9C2Y0", "WBGene00006833", "species_29438" ] }, "reaction_10514372": { "compartment": "compartment_7660", "id": "reaction_10514372", "reactome": "R-CEL-199839", "name": "AKT can phosphorylate RSK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10514366" ], "products": [ "species_113582", "species_10514370" ], "modifiers": [ [ "species_10514266", "catalyst" ] ], "additional_components": [ "WBGene00012929", "WBGene00012929", "G4S4W1", "WBGene00016980", "Q17941", "WBGene00000102", "Q9XTG7", "WBGene00000103" ] }, "reaction_10514300": { "compartment": "compartment_7660", "id": "reaction_10514300", "reactome": "R-CEL-199299", "name": "AKT phosphorylates FOXO transcription factors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10514274" ], "products": [ "species_113582", "species_10514285" ], "modifiers": [ [ "species_10514266", "catalyst" ] ], "additional_components": [ "WBGene00000912", "WBGene00000912", "G4S4W1", "WBGene00016980", "Q17941", "WBGene00000102", "Q9XTG7", "WBGene00000103" ] }, "reaction_10514269": { "compartment": "compartment_7660", "id": "reaction_10514269", "reactome": "R-CEL-199298", "name": "AKT phosphorylates CREB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10514243" ], "products": [ "species_113582", "species_10514246" ], "modifiers": [ [ "species_10514266", "catalyst" ] ], "additional_components": [ "WBGene00000793", "WBGene00000793", "G4S4W1", "WBGene00016980", "Q17941", "WBGene00000102", "Q9XTG7", "WBGene00000103" ] }, "reaction_10514382": { "compartment": "compartment_7660", "id": "reaction_10514382", "reactome": "R-CEL-199863", "name": "AKT can phosphorylate NR4A1 (NUR77)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10514377" ], "products": [ "species_113582", "species_10514380" ], "modifiers": [ [ "species_10514266", "catalyst" ] ], "additional_components": [ "WBGene00003605", "WBGene00003605", "G4S4W1", "WBGene00016980", "Q17941", "WBGene00000102", "Q9XTG7", "WBGene00000103" ] }, "reaction_10571544": { "compartment": "compartment_70101", "id": "reaction_10571544", "reactome": "R-CEL-9027043", "name": "CYPs hydroxylate DHA to 14(R)-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29368", "species_29364", "species_9024011" ], "products": [ "species_29356", "species_29366", "species_9027049" ], "modifiers": [ [ "species_10507820", "catalyst" ] ], "additional_components": [ "Q965T7", "WBGene00021710", "O16671", "WBGene00018261", "O45659", "WBGene00010589", "Q9N4Q4", "WBGene00021168", "A0A0M7RF98", "WBGene00018264", "O16673", "WBGene00018260", "O61204", "WBGene00015045", "Q9N5I1", "WBGene00019565", "G5ECD0", "WBGene00007362", "O44649", "WBGene00019473", "O61935", "WBGene00020386", "G5EE22", "WBGene00012448", "O44650", "WBGene00019472", "O62377", "WBGene00011699", "H2KY69", "WBGene00015044", "O44651", "WBGene00019471", "O62378", "WBGene00011698", "H2KYS3", "WBGene00000905", "O44652", "WBGene00019470", "P90771", "WBGene00007913", "O02627", "WBGene00015399", "O44655", "WBGene00015040", "Q20315", "WBGene00018333", "O02628", "WBGene00015400", "O44656", "WBGene00015041", "Q27465", "WBGene00015135", "O02641", "WBGene00019967", "O44657", "WBGene00015042", "Q27470", "WBGene00015709", "O16220", "WBGene00016786", "O44658", "WBGene00015043", "Q27471", "WBGene00016092", "O16362", "WBGene00018413", "O44704", "WBGene00016686", "Q27482", "WBGene00016768", "O16482", "WBGene00016860", "O44706", "WBGene00016697", "Q27499", "WBGene00018334", "O16670", "WBGene00018262", "O45364", "WBGene00008829" ] }, "reaction_10523346": { "compartment": "compartment_70101", "id": "reaction_10523346", "reactome": "R-CEL-428941", "name": "P2Y purinoceptor 1 activates MAP kinase p38 alpha", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10523344" ], "products": [ "species_10512654", "species_29370" ], "modifiers": [ [ "species_10508937", "catalyst" ] ], "additional_components": [ "WBGene00004055", "WBGene00004055", "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196", "species_29438" ] }, "reaction_10521881": { "compartment": "compartment_70101", "id": "reaction_10521881", "reactome": "R-CEL-418662", "name": "Src activation following P2Y purinoceptor activation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10513079" ], "products": [ "species_10518252" ], "modifiers": [], "additional_components": [ "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635" ] }, "reaction_10556833": { "compartment": "compartment_70101", "id": "reaction_10556833", "reactome": "R-CEL-5691431", "name": "PSMD14 cleaves K63-linked ubiquitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10511035" ], "products": [ "species_10511033" ], "modifiers": [ [ "species_10502380", "catalyst" ] ], "additional_components": [ "P37165", "WBGene00006725", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "WBGene00004467" ] }, "reaction_10556830": { "compartment": "compartment_7660", "id": "reaction_10556830", "reactome": "R-CEL-5691381", "name": "MYSM1 deubiquitinates Histone H2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10556825" ], "products": [ "species_10502318", "species_10556827" ], "modifiers": [ [ "species_10556825", "catalyst" ] ], "additional_components": [ "P34545", "WBGene00000366", "Q9N3S7", "WBGene00021636", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "P34545", "WBGene00000366", "Q9N3S7", "WBGene00021636", "P34545", "WBGene00000366", "Q9N3S7", "WBGene00021636" ] }, "reaction_10511057": { "compartment": "compartment_5460", "id": "reaction_10511057", "reactome": "R-CEL-169260", "name": "Reducing equivalents from beta-oxidation of fatty acids transfer to ETF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10511052", "species_31649" ], "products": [ "species_10511054", "species_113596" ], "modifiers": [ [ "species_10511052", "catalyst" ] ], "additional_components": [ "Q93615", "WBGene00009187", "Q9TXI4", "WBGene00017734", "species_76577", "species_113596", "species_31649", "Q93615", "WBGene00009187", "Q9TXI4", "WBGene00017734", "species_76577", "Q93615", "WBGene00009187", "Q9TXI4", "WBGene00017734", "species_76577", "species_113596" ] }, "reaction_10511065": { "compartment": "compartment_5460", "id": "reaction_10511065", "reactome": "R-CEL-169270", "name": "ETFDH oxidises ETF (reduced) to ETF, reduces CoQ to QH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73663", "species_10511054" ], "products": [ "species_10511052", "species_76633" ], "modifiers": [ [ "species_10511062", "catalyst" ] ], "additional_components": [ "species_31649", "Q93615", "WBGene00009187", "Q9TXI4", "WBGene00017734", "species_76577", "Q93615", "WBGene00009187", "Q9TXI4", "WBGene00017734", "species_76577", "species_113596", "WBGene00002855" ] }, "reaction_10562852": { "compartment": "compartment_5460", "id": "reaction_10562852", "reactome": "R-CEL-6800868", "name": "NDUF subunits bind to form the IP subcomplex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10561725", "species_10561709", "species_10561720", "species_10561718", "species_10561716" ], "products": [ "species_10561727" ], "modifiers": [], "additional_components": [ "WBGene00020417", "Q93873", "WBGene00001520", "Q09644", "WBGene00014227", "Q22619", "WBGene00020636", "Q94360", "WBGene00012376", "Q9N3H3", "WBGene00021800", "species_113596", "Q9N3H3", "WBGene00021800", "species_113596", "Q94360", "WBGene00012376", "Q22619", "WBGene00020636", "Q93873", "WBGene00001520", "Q09644", "WBGene00014227", "Q86NC2", "WBGene00020417" ] }, "reaction_10561780": { "compartment": "compartment_5460", "id": "reaction_10561780", "reactome": "R-CEL-6799203", "name": "IP subcomplex binds NDUFAF3, NDUFAF4, TIMMDC1 to form Intermediate 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10561742", "species_10561727", "species_10561737", "species_10561732" ], "products": [ "species_10561744" ], "modifiers": [], "additional_components": [ "WBGene00021421", "Q9N3H3", "WBGene00021800", "species_113596", "Q94360", "WBGene00012376", "Q22619", "WBGene00020636", "Q93873", "WBGene00001520", "Q09644", "WBGene00014227", "Q86NC2", "WBGene00020417", "WBGene00007113", "WBGene00011123", "Q93931", "WBGene00011123", "Q17439", "WBGene00007113", "Q9N3H3", "WBGene00021800", "species_113596", "Q94360", "WBGene00012376", "Q22619", "WBGene00020636", "Q93873", "WBGene00001520", "Q09644", "WBGene00014227", "Q86NC2", "WBGene00020417", "I2HAE1", "WBGene00021421" ] }, "reaction_10561748": { "compartment": "compartment_70616", "id": "reaction_10561748", "reactome": "R-CEL-6799178", "name": "Intermediate 1 binds HP subcomplex to form Intermediate 2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10561700", "species_10561744" ], "products": [ "species_10561746" ], "modifiers": [], "additional_components": [ "Q20412", "WBGene00009712", "Q18359", "WBGene00007880", "Q93831", "WBGene00010326", "Q18095", "WBGene00007684", "Q9BL33", "WBGene00022169", "Q9XWG2", "WBGene00013406", "Q23098", "WBGene00012166", "O44955", "WBGene00016393", "H2KYV1", "WBGene00016118", "O18236", "WBGene00013308", "Q9U241", "WBGene00013237", "P90789", "WBGene00008414", "O44509", "WBGene00018361", "O02267", "WBGene00009740", "Q21233", "WBGene00019401", "species_113596", "Q9XWJ5", "WBGene00013094", "Q9BL03", "WBGene00021849", "Q18036", "WBGene00015810", "Q93931", "WBGene00011123", "Q17439", "WBGene00007113", "Q9N3H3", "WBGene00021800", "species_113596", "Q94360", "WBGene00012376", "Q22619", "WBGene00020636", "Q93873", "WBGene00001520", "Q09644", "WBGene00014227", "Q86NC2", "WBGene00020417", "I2HAE1", "WBGene00021421", "Q93931", "WBGene00011123", "Q17439", "WBGene00007113", "Q9N3H3", "WBGene00021800", "species_113596", "Q94360", "WBGene00012376", "Q22619", "WBGene00020636", "Q93873", "WBGene00001520", "Q09644", "WBGene00014227", "Q86NC2", "WBGene00020417", "I2HAE1", "WBGene00021421", "Q20412", "WBGene00009712", "Q18359", "WBGene00007880", "Q93831", "WBGene00010326", "Q18095", "WBGene00007684", "Q9BL33", "WBGene00022169", "Q9XWG2", "WBGene00013406", "Q23098", "WBGene00012166", "O44955", "WBGene00016393", "H2KYV1", "WBGene00016118", "O18236", "WBGene00013308", "Q9U241", "WBGene00013237", "P90789", "WBGene00008414", "O44509", "WBGene00018361", "O02267", "WBGene00009740", "Q21233", "WBGene00019401", "Q9XWJ5", "WBGene00013094", "Q9BL03", "WBGene00021849", "Q18036", "WBGene00015810" ] }, "reaction_10521531": { "compartment": "compartment_7660", "id": "reaction_10521531", "reactome": "R-CEL-400204", "name": "PPARA binds RXRA forming PPARA:RXRA heterodimer at promoter of target gene", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10514477", "species_422139", "species_10519403" ], "products": [ "species_10521529" ], "modifiers": [], "additional_components": [ "WBGene00003681", "P41830", "WBGene00004786", "Q10902", "WBGene00003601", "Q20765", "WBGene00003606", "Q9XUK7", "WBGene00003675", "P41830", "WBGene00004786", "Q10902", "WBGene00003601", "Q20765", "WBGene00003606", "Q9XUK7", "WBGene00003675", "Q9U2R6", "WBGene00003681" ] }, "reaction_10542707": { "compartment": "compartment_70101", "id": "reaction_10542707", "reactome": "R-CEL-2106614", "name": "Duplex miRNA is loaded into Argonaute", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10542705" ], "products": [ "species_10516856" ], "modifiers": [], "additional_components": [ "P34529", "WBGene00000939", "G5EBF5", "WBGene00004326", "G5EES3", "WBGene00000105", "P34529", "WBGene00000939", "G5EES3", "WBGene00000105", "G5EBF5", "WBGene00004326" ] }, "reaction_10516876": { "compartment": "compartment_70101", "id": "reaction_10516876", "reactome": "R-CEL-210805", "name": "Removal of miRNA passenger strand", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10516856" ], "products": [ "species_10516874" ], "modifiers": [], "additional_components": [ "P34529", "WBGene00000939", "G5EES3", "WBGene00000105", "G5EBF5", "WBGene00004326", "P34529", "WBGene00000939", "G5EES3", "WBGene00000105", "G5EBF5", "WBGene00004326" ] }, "reaction_10567937": { "compartment": "compartment_70101", "id": "reaction_10567937", "reactome": "R-CEL-8931974", "name": "N6AMT2 transfers 3xCH3 from 3xAdoMet to EEF1A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71284", "species_10509904" ], "products": [ "species_10567929", "species_71285" ], "modifiers": [ [ "species_10567934", "catalyst" ] ], "additional_components": [ "WBGene00001168", "WBGene00001168", "WBGene00043057" ] }, "reaction_10568005": { "compartment": "compartment_70101", "id": "reaction_10568005", "reactome": "R-CEL-8932413", "name": "METTL10 transfers 3xCH3 from 3xAdoMet to EEF1A1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71284", "species_10509904" ], "products": [ "species_10567997", "species_71285" ], "modifiers": [ [ "species_10568002", "catalyst" ] ], "additional_components": [ "WBGene00001168", "WBGene00001168", "WBGene00017919" ] }, "reaction_10567926": { "compartment": "compartment_5460", "id": "reaction_10567926", "reactome": "R-CEL-8931858", "name": "ETFBKMT transfers 3xCH3 from 3xAdoMet to ETFB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10511050", "species_2162265" ], "products": [ "species_10567918", "species_2162252" ], "modifiers": [ [ "species_10567923", "catalyst" ] ], "additional_components": [ "WBGene00017734", "WBGene00017734", "WBGene00016492" ] }, "reaction_10567962": { "compartment": "compartment_70101", "id": "reaction_10567962", "reactome": "R-CEL-8932276", "name": "VCPKMT (METTL21D) transfers 3xCH3 from 3xAdoMet to VCP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71284", "species_10551284" ], "products": [ "species_71285", "species_10567954" ], "modifiers": [ [ "species_10567959", "catalyst" ] ], "additional_components": [ "WBGene00008053", "WBGene00008053", "WBGene00016591" ] }, "reaction_10523164": { "compartment": "compartment_876", "id": "reaction_10523164", "reactome": "R-CEL-428510", "name": "ROBO3.1 antagonizes ROBO1/ROBO2 to allow floor plate crossing", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10523160", "species_10523158" ], "products": [ "species_10523162" ], "modifiers": [], "additional_components": [ "WBGene00004732", "H2KZ60", "WBGene00016354", "Q18806", "WBGene00004370", "H2KZ60", "WBGene00016354", "Q18806", "WBGene00004370", "Q53U87", "WBGene00004732" ] }, "reaction_10568768": { "compartment": "compartment_17957", "id": "reaction_10568768", "reactome": "R-CEL-8944257", "name": "Association of procollagen type XXIV", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10539093" ], "products": [ "species_10540952" ], "modifiers": [], "additional_components": [ "WBGene00000659", "Q21437", "WBGene00000659" ] }, "reaction_10568770": { "compartment": "compartment_17957", "id": "reaction_10568770", "reactome": "R-CEL-8944261", "name": "Association of procollagen type XIII", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10540942" ], "products": [ "species_10540944" ], "modifiers": [], "additional_components": [ "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689", "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689" ] }, "reaction_10568772": { "compartment": "compartment_17957", "id": "reaction_10568772", "reactome": "R-CEL-8944262", "name": "Association of procollagen type X", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10540932" ], "products": [ "species_10540934" ], "modifiers": [], "additional_components": [ "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689", "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689" ] }, "reaction_10568774": { "compartment": "compartment_17957", "id": "reaction_10568774", "reactome": "R-CEL-8944263", "name": "Association of procollagen type II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10540908" ], "products": [ "species_10540910" ], "modifiers": [], "additional_components": [ "O76368", "WBGene00000674", "Q09457", "WBGene00000251", "Q9N4U2", "WBGene00000647", "O76368", "WBGene00000674", "Q09457", "WBGene00000251", "Q9N4U2", "WBGene00000647" ] }, "reaction_10539495": { "compartment": "compartment_17957", "id": "reaction_10539495", "reactome": "R-CEL-2002401", "name": "Association of procollagen type XVIII", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10539097" ], "products": [ "species_10539493" ], "modifiers": [], "additional_components": [ "WBGene00000659", "Q21437", "WBGene00000659" ] }, "reaction_10568776": { "compartment": "compartment_17957", "id": "reaction_10568776", "reactome": "R-CEL-8944266", "name": "Association of procollagen type XI", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10540908", "species_10540938", "species_10540936" ], "products": [ "species_10540940" ], "modifiers": [], "additional_components": [ "O76368", "WBGene00000674", "Q09457", "WBGene00000251", "Q9N4U2", "WBGene00000647", "Q9N3X9", "WBGene00000689", "O17641", "WBGene00000751", "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689", "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689", "O76368", "WBGene00000674", "Q09457", "WBGene00000251", "Q9N4U2", "WBGene00000647" ] }, "reaction_10568754": { "compartment": "compartment_17957", "id": "reaction_10568754", "reactome": "R-CEL-8944214", "name": "Association of procollagen type I", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10536687", "species_10539099" ], "products": [ "species_10540906" ], "modifiers": [], "additional_components": [ "WBGene00000647", "WBGene00000647", "Q9N4U2", "WBGene00000647" ] }, "reaction_10568756": { "compartment": "compartment_17957", "id": "reaction_10568756", "reactome": "R-CEL-8944218", "name": "Association of procollagen type VIII", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10539063", "species_10540928" ], "products": [ "species_10540930" ], "modifiers": [], "additional_components": [ "WBGene00000751", "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689", "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689" ] }, "reaction_10568758": { "compartment": "compartment_17957", "id": "reaction_10568758", "reactome": "R-CEL-8944223", "name": "Association of procollagen type V", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10540920", "species_10539061", "species_10540916" ], "products": [ "species_10540926" ], "modifiers": [], "additional_components": [ "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689", "WBGene00002280", "O76368", "WBGene00000674", "Q09457", "WBGene00000251", "Q9N4U2", "WBGene00000647", "O76368", "WBGene00000674", "Q09457", "WBGene00000251", "Q9N4U2", "WBGene00000647", "P17140", "WBGene00002280", "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689" ] }, "reaction_10568762": { "compartment": "compartment_17957", "id": "reaction_10568762", "reactome": "R-CEL-8944233", "name": "Association of procollagen type XIX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10540948" ], "products": [ "species_10540950" ], "modifiers": [], "additional_components": [ "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689", "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689" ] }, "reaction_10568764": { "compartment": "compartment_17957", "id": "reaction_10568764", "reactome": "R-CEL-8944240", "name": "Association of procollagen type III", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10540912" ], "products": [ "species_10540914" ], "modifiers": [], "additional_components": [ "Q9N4U2", "WBGene00000647", "O76368", "WBGene00000674", "Q09457", "WBGene00000251", "Q9N4U2", "WBGene00000647", "O76368", "WBGene00000674", "Q09457", "WBGene00000251" ] }, "reaction_10568766": { "compartment": "compartment_17957", "id": "reaction_10568766", "reactome": "R-CEL-8944242", "name": "Association of procollagen type XXVII", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10539095" ], "products": [ "species_10540954" ], "modifiers": [], "additional_components": [ "WBGene00002280", "P17140", "WBGene00002280" ] }, "reaction_10512308": { "compartment": "compartment_70101", "id": "reaction_10512308", "reactome": "R-CEL-183058", "name": "Phosphorylation of CBL (EGFR:GRB2:CBL)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10512305" ], "products": [ "species_29370", "species_10512272" ], "modifiers": [ [ "species_10512305", "catalyst" ] ], "additional_components": [ "P24348", "WBGene00002299", "P29355", "WBGene00004774", "Q19019", "WBGene00004829", "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "P29355", "WBGene00004774", "P24348", "WBGene00002299", "P29355", "WBGene00004774", "Q19019", "WBGene00004829" ] }, "reaction_10566342": { "compartment": "compartment_876", "id": "reaction_10566342", "reactome": "R-CEL-8867041", "name": "EGFR phosphorylates EPS15", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10566337" ], "products": [ "species_29370", "species_10566339" ], "modifiers": [ [ "species_10566337", "catalyst" ] ], "additional_components": [ "Q9BIF4", "WBGene00001224", "species_179856", "Q18453", "WBGene00004682", "Q9BI71", "WBGene00001329", "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "B1V8A0", "WBGene00006791", "P29355", "WBGene00004774", "Q17796", "WBGene00004101", "O01498", "WBGene00004109", "Q9BIF4", "WBGene00001224", "species_179856", "Q17796", "WBGene00004101", "O01498", "WBGene00004109", "Q18453", "WBGene00004682", "Q9BI71", "WBGene00001329", "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "B1V8A0", "WBGene00006791", "P29355", "WBGene00004774", "Q9BIF4", "WBGene00001224", "species_179856", "Q18453", "WBGene00004682", "Q9BI71", "WBGene00001329", "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "B1V8A0", "WBGene00006791", "P29355", "WBGene00004774", "Q17796", "WBGene00004101", "O01498", "WBGene00004109" ] }, "reaction_10512298": { "compartment": "compartment_70101", "id": "reaction_10512298", "reactome": "R-CEL-183036", "name": "Ubiquitination of stimulated EGFR (CBL:GRB2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502375", "species_10512272" ], "products": [ "species_10512290" ], "modifiers": [ [ "species_10512272", "catalyst" ], [ "species_10512296", "inhibitor" ] ], "additional_components": [ "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "P29355", "WBGene00004774", "P29355", "WBGene00004774", "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "P29355", "WBGene00004774", "WBGene00011755" ] }, "reaction_10512315": { "compartment": "compartment_70101", "id": "reaction_10512315", "reactome": "R-CEL-183084", "name": "CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502375", "species_10512310" ], "products": [ "species_10512312", "species_10512305" ], "modifiers": [ [ "species_10512310", "catalyst" ] ], "additional_components": [ "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "P29355", "WBGene00004774", "Q05062", "WBGene00000390", "species_29438", "Q21430", "WBGene00010776", "Q05062", "WBGene00000390", "species_29438", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "Q21430", "WBGene00010776", "P24348", "WBGene00002299", "P29355", "WBGene00004774", "Q19019", "WBGene00004829", "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "P29355", "WBGene00004774", "Q05062", "WBGene00000390", "species_29438", "Q21430", "WBGene00010776" ] }, "reaction_10512270": { "compartment": "compartment_70101", "id": "reaction_10512270", "reactome": "R-CEL-182986", "name": "CBL-mediated ubiquitination of CIN85", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10512255", "species_10502375" ], "products": [ "species_10512265" ], "modifiers": [ [ "species_10512255", "catalyst" ] ], "additional_components": [ "Q9BIF4", "WBGene00001224", "B1V8A0", "WBGene00006791", "Q18453", "WBGene00004682", "Q9BI71", "WBGene00001329", "P24348", "WBGene00002299", "Q19019", "WBGene00004829", "Q17796", "WBGene00004101", "O01498", "WBGene00004109", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "Q9BIF4", "WBGene00001224", "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "B1V8A0", "WBGene00006791", "Q18453", "WBGene00004682", "Q9BI71", "WBGene00001329", "Q17796", "WBGene00004101", "O01498", "WBGene00004109", "Q9BIF4", "WBGene00001224", "B1V8A0", "WBGene00006791", "Q18453", "WBGene00004682", "Q9BI71", "WBGene00001329", "P24348", "WBGene00002299", "Q19019", "WBGene00004829", "Q17796", "WBGene00004101", "O01498", "WBGene00004109" ] }, "reaction_10512303": { "compartment": "compartment_70101", "id": "reaction_10512303", "reactome": "R-CEL-183052", "name": "CBL binds to GRB2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10512267", "species_10506871" ], "products": [ "species_10512301" ], "modifiers": [], "additional_components": [ "WBGene00004829", "WBGene00004774", "P29355", "WBGene00004774", "Q19019", "WBGene00004829" ] }, "reaction_10512319": { "compartment": "compartment_70101", "id": "reaction_10512319", "reactome": "R-CEL-183094", "name": "CDC42:GTP binds CBL:Beta-Pix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10512286", "species_10512267" ], "products": [ "species_10512317" ], "modifiers": [], "additional_components": [ "Q05062", "WBGene00000390", "species_29438", "Q21430", "WBGene00010776", "WBGene00004829", "Q19019", "WBGene00004829", "Q05062", "WBGene00000390", "species_29438", "Q21430", "WBGene00010776" ] }, "reaction_10566350": { "compartment": "compartment_876", "id": "reaction_10566350", "reactome": "R-CEL-8867047", "name": "PTPN3 dephosphorylates EPS15", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10566339" ], "products": [ "species_29372", "species_10566337" ], "modifiers": [ [ "species_10566347", "catalyst" ] ], "additional_components": [ "Q9BIF4", "WBGene00001224", "species_179856", "Q17796", "WBGene00004101", "O01498", "WBGene00004109", "Q18453", "WBGene00004682", "Q9BI71", "WBGene00001329", "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "B1V8A0", "WBGene00006791", "P29355", "WBGene00004774", "Q9BIF4", "WBGene00001224", "species_179856", "Q18453", "WBGene00004682", "Q9BI71", "WBGene00001329", "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "B1V8A0", "WBGene00006791", "P29355", "WBGene00004774", "Q17796", "WBGene00004101", "O01498", "WBGene00004109", "WBGene00004213" ] }, "reaction_10541063": { "compartment": "compartment_984", "id": "reaction_10541063", "reactome": "R-CEL-2022381", "name": "Cathepsin Z (Cathepsin X) hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_10541036" ], "products": [ "species_10528011" ], "modifiers": [ [ "species_10541060", "catalyst" ] ], "additional_components": [ "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "A9Z1L1", "WBGene00005648", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "A9Z1L1", "WBGene00005648", "G5ECY2", "WBGene00005644", "Q9XWA4", "WBGene00013764", "Q9XXQ7", "WBGene00013764", "G5EGP8", "WBGene00000788", "P92005", "WBGene00000789", "Q18740", "WBGene00008231", "Q9U2X1", "WBGene00013764" ] }, "reaction_10541193": { "compartment": "compartment_984", "id": "reaction_10541193", "reactome": "R-CEL-2022403", "name": "Renin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10541102", "species_109276" ], "products": [ "species_10541036" ], "modifiers": [ [ "species_10541190", "catalyst" ], [ "species_10541190", "catalyst" ], [ "species_2022362", "inhibitor" ] ], "additional_components": [ "A9Z1L1", "WBGene00005648", "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "A9Z1L1", "WBGene00005648", "Q9XTY9", "WBGene00010993", "Q21966", "WBGene00000217", "O01530", "WBGene00000219", "Q22972", "WBGene00017881", "O01531", "WBGene00017678", "Q7JKL9", "WBGene00013973", "O01532", "WBGene00000218", "Q86NE0", "WBGene00000215", "O45072", "WBGene00015700", "Q8MYN5", "WBGene00012683", "P55956", "WBGene00000216", "G5EC01", "WBGene00077655", "Q8MYN6", "WBGene00012682", "Q18020", "WBGene00007605", "G5EEI4", "WBGene00000214", "Q8MYN7", "WBGene00012681", "Q9XTY9", "WBGene00010993", "Q21966", "WBGene00000217", "O01530", "WBGene00000219", "Q22972", "WBGene00017881", "O01531", "WBGene00017678", "Q7JKL9", "WBGene00013973", "O01532", "WBGene00000218", "Q86NE0", "WBGene00000215", "O45072", "WBGene00015700", "Q8MYN5", "WBGene00012683", "P55956", "WBGene00000216", "G5EC01", "WBGene00077655", "Q8MYN6", "WBGene00012682", "Q18020", "WBGene00007605", "G5EEI4", "WBGene00000214", "Q8MYN7", "WBGene00012681" ] }, "reaction_10541065": { "compartment": "compartment_984", "id": "reaction_10541065", "reactome": "R-CEL-2022396", "name": "Neprilysin hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-7)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_10541036" ], "products": [ "species_10541012" ], "modifiers": [ [ "species_10541017", "catalyst" ] ], "additional_components": [ "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "A9Z1L1", "WBGene00005648", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "A9Z1L1", "WBGene00005648", "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "WBGene00013926" ] }, "reaction_10541930": { "compartment": "compartment_984", "id": "reaction_10541930", "reactome": "R-CEL-2028294", "name": "Mast Cell Carboxypeptidase hydrolyzes Angiotensin-(1-10) to Yield Angiotensin-(1-9)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_10541036" ], "products": [ "species_10540996" ], "modifiers": [ [ "species_10541927", "catalyst" ] ], "additional_components": [ "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "A9Z1L1", "WBGene00005648", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "A9Z1L1", "WBGene00005648", "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q9BL88", "WBGene00021984", "H2L0D7", "WBGene00021984", "G3MU29", "WBGene00021984", "Q9TZC6", "WBGene00021984", "H2L0K5", "WBGene00021984", "G5EC13", "WBGene00021984", "Q9XU75", "WBGene00011235", "Q6A577", "WBGene00021984", "G5EC96", "WBGene00021984" ] }, "reaction_10541196": { "compartment": "compartment_984", "id": "reaction_10541196", "reactome": "R-CEL-2022405", "name": "ACE hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_10541036" ], "products": [ "species_10528011" ], "modifiers": [ [ "species_10541067", "catalyst" ], [ "species_188972", "catalyst" ] ], "additional_components": [ "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "A9Z1L1", "WBGene00005648", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "A9Z1L1", "WBGene00005648", "G5ECY2", "WBGene00005644", "WBGene00000039" ] }, "reaction_10572173": { "compartment": "compartment_984", "id": "reaction_10572173", "reactome": "R-CEL-9614933", "name": "ACEIs bind ACE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9614913", "species_10542353" ], "products": [ "species_10542356" ], "modifiers": [], "additional_components": [ "WBGene00000039", "Q18581", "WBGene00000039" ] }, "reaction_10541070": { "compartment": "compartment_984", "id": "reaction_10541070", "reactome": "R-CEL-2022398", "name": "ACE hydrolyzes Angiotensin-(1-9) to Angiotensin-(1-7)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_10540996" ], "products": [ "species_10541012" ], "modifiers": [ [ "species_10541067", "catalyst" ] ], "additional_components": [ "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "A9Z1L1", "WBGene00005648", "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "A9Z1L1", "WBGene00005648", "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "WBGene00000039" ] }, "reaction_10541235": { "compartment": "compartment_984", "id": "reaction_10541235", "reactome": "R-CEL-2022412", "name": "Renin hydrolyzes Angiotensinogen to Angiotensin-(1-10)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10541102", "species_109276" ], "products": [ "species_10541036" ], "modifiers": [ [ "species_10541232", "catalyst" ], [ "species_2022362", "inhibitor" ] ], "additional_components": [ "A9Z1L1", "WBGene00005648", "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "A9Z1L1", "WBGene00005648", "Q22972", "WBGene00017881", "Q7JKL9", "WBGene00013973", "Q86NE0", "WBGene00000215", "Q8MYN5", "WBGene00012683", "Q8MYN6", "WBGene00012682", "Q8MYN7", "WBGene00012681", "G5EC01", "WBGene00077655", "G5EEI4", "WBGene00000214", "O01530", "WBGene00000219", "O01531", "WBGene00017678", "O01532", "WBGene00000218", "O45072", "WBGene00015700", "P55956", "WBGene00000216", "Q18020", "WBGene00007605", "Q21966", "WBGene00000217" ] }, "reaction_10541044": { "compartment": "compartment_984", "id": "reaction_10541044", "reactome": "R-CEL-2022378", "name": "ACE2 hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-9)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_10541036" ], "products": [ "species_10540996" ], "modifiers": [ [ "species_10541041", "catalyst" ] ], "additional_components": [ "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "A9Z1L1", "WBGene00005648", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "A9Z1L1", "WBGene00005648", "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "WBGene00000039" ] }, "reaction_10542358": { "compartment": "compartment_984", "id": "reaction_10542358", "reactome": "R-CEL-2065355", "name": "Secreted ACE hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_10541036" ], "products": [ "species_10528011" ], "modifiers": [ [ "species_10542353", "catalyst" ], [ "species_188972", "catalyst" ], [ "species_10542356", "inhibitor" ] ], "additional_components": [ "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "A9Z1L1", "WBGene00005648", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "A9Z1L1", "WBGene00005648", "G5ECY2", "WBGene00005644", "WBGene00000039", "Q18581", "WBGene00000039" ] }, "reaction_10541046": { "compartment": "compartment_984", "id": "reaction_10541046", "reactome": "R-CEL-2022379", "name": "ACE2 hydrolyzes Angiotensin-(1-8) to Angiotensin-(1-7)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_10528011" ], "products": [ "species_10541012" ], "modifiers": [ [ "species_10541041", "catalyst" ] ], "additional_components": [ "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "A9Z1L1", "WBGene00005648", "G5ECY2", "WBGene00005644", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "A9Z1L1", "WBGene00005648", "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "WBGene00000039" ] }, "reaction_10572216": { "compartment": "compartment_984", "id": "reaction_10572216", "reactome": "R-CEL-9619024", "name": "CES1trimer hydrolyses ACEI pro-drugs to ACEIs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113519", "species_9619052" ], "products": [ "species_8878776", "species_9619021" ], "modifiers": [ [ "species_10557032", "catalyst" ] ], "additional_components": [ "Q04457", "WBGene00001578" ] }, "reaction_10542396": { "compartment": "compartment_984", "id": "reaction_10542396", "reactome": "R-CEL-2065357", "name": "Prorenin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10541102", "species_109276" ], "products": [ "species_10541036" ], "modifiers": [ [ "species_10542393", "catalyst" ], [ "species_2022362", "inhibitor" ] ], "additional_components": [ "A9Z1L1", "WBGene00005648", "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "A9Z1L1", "WBGene00005648", "Q9XTY9", "WBGene00010993", "O01532", "WBGene00000218", "O45072", "WBGene00015700", "P55956", "WBGene00000216", "Q18020", "WBGene00007605", "Q21966", "WBGene00000217", "Q22972", "WBGene00017881", "Q7JKL9", "WBGene00013973", "Q86NE0", "WBGene00000215", "Q8MYN5", "WBGene00012683", "Q8MYN6", "WBGene00012682", "Q8MYN7", "WBGene00012681", "G5EC01", "WBGene00077655", "G5EEI4", "WBGene00000214", "O01530", "WBGene00000219", "O01531", "WBGene00017678" ] }, "reaction_10541020": { "compartment": "compartment_984", "id": "reaction_10541020", "reactome": "R-CEL-2022368", "name": "Neprilysin hydrolyzes Angiotensin-(1-9) to Angiotensin-(1-7)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_10540996" ], "products": [ "species_10541012" ], "modifiers": [ [ "species_10541017", "catalyst" ] ], "additional_components": [ "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "A9Z1L1", "WBGene00005648", "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "A9Z1L1", "WBGene00005648", "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "WBGene00013926" ] }, "reaction_10549712": { "compartment": "compartment_7660", "id": "reaction_10549712", "reactome": "R-CEL-4755494", "name": "PIAS1,2-1 SUMOylate NR5A2 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10549685", "species_10546081" ], "products": [ "species_10549707", "species_10546073" ], "modifiers": [ [ "species_10549709", "catalyst" ] ], "additional_components": [ "CHEBI:77361", "Q9N2W3", "WBGene00022374", "Q18190", "WBGene00016126", "Q9XTJ4", "WBGene00003602", "Q19345", "WBGene00003623", "Q21104", "WBGene00003629", "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "CHEBI:77361", "P55853", "WBGene00004888", "Q21104", "WBGene00003629", "Q9N2W3", "WBGene00022374", "Q9XTJ4", "WBGene00003602", "Q18190", "WBGene00016126", "Q19345", "WBGene00003623", "WBGene00006706", "Q21970", "WBGene00011259", "Q94361", "WBGene00001574" ] }, "reaction_10549218": { "compartment": "compartment_7660", "id": "reaction_10549218", "reactome": "R-CEL-4546386", "name": "PIAS1,3 SUMOylates NR5A1 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546081", "species_10519472" ], "products": [ "species_10549213", "species_10546073" ], "modifiers": [ [ "species_10549215", "catalyst" ] ], "additional_components": [ "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "WBGene00003623", "P55853", "WBGene00004888", "Q19345", "WBGene00003623", "WBGene00006706", "Q21970", "WBGene00011259", "Q94361", "WBGene00001574" ] }, "reaction_10549683": { "compartment": "compartment_7660", "id": "reaction_10549683", "reactome": "R-CEL-4755419", "name": "SUMOylation of NR1H4 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10549672", "species_10546081" ], "products": [ "species_10546073", "species_10549681" ], "modifiers": [], "additional_components": [ "G5ECR9", "WBGene00006790", "CHEBI:16755", "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "WBGene00006706", "CHEBI:16755", "P55853", "WBGene00004888", "G5ECR9", "WBGene00006790" ] }, "reaction_10549573": { "compartment": "compartment_7660", "id": "reaction_10549573", "reactome": "R-CEL-4719447", "name": "PIAS2-2 SUMOylates THRA with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546081", "species_10519457" ], "products": [ "species_10546073", "species_10549571" ], "modifiers": [ [ "species_10548942", "catalyst" ] ], "additional_components": [ "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "P41830", "WBGene00004786", "Q10902", "WBGene00003601", "Q20765", "WBGene00003606", "Q9XUK7", "WBGene00003675", "WBGene00006706", "P41830", "WBGene00004786", "Q10902", "WBGene00003601", "Q20765", "WBGene00003606", "Q9XUK7", "WBGene00003675", "P55853", "WBGene00004888", "WBGene00001574" ] }, "reaction_10549096": { "compartment": "compartment_7660", "id": "reaction_10549096", "reactome": "R-CEL-4341048", "name": "SUMOylation of RXRA with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10514477", "species_10546081" ], "products": [ "species_10546073", "species_10549094" ], "modifiers": [ [ "species_10546081", "catalyst" ] ], "additional_components": [ "WBGene00003681", "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "WBGene00006706", "P55853", "WBGene00004888", "Q9U2R6", "WBGene00003681", "Q95017", "WBGene00006706", "P55853", "WBGene00004888" ] }, "reaction_10549548": { "compartment": "compartment_7660", "id": "reaction_10549548", "reactome": "R-CEL-4719436", "name": "PIAS2,3,4 SUMOylate RORA with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10519389", "species_10546081" ], "products": [ "species_10546073", "species_10549543" ], "modifiers": [ [ "species_10549545", "catalyst" ] ], "additional_components": [ "WBGene00003622", "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "WBGene00006706", "P41828", "WBGene00003622", "P55853", "WBGene00004888", "Q21970", "WBGene00011259", "Q94361", "WBGene00001574" ] }, "reaction_10549117": { "compartment": "compartment_7660", "id": "reaction_10549117", "reactome": "R-CEL-4341070", "name": "PIAS4 SUMOylates PPARA with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10519403", "species_10546081" ], "products": [ "species_10549115", "species_10546073" ], "modifiers": [ [ "species_10546168", "catalyst" ] ], "additional_components": [ "P41830", "WBGene00004786", "Q10902", "WBGene00003601", "Q20765", "WBGene00003606", "Q9XUK7", "WBGene00003675", "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "Q10902", "WBGene00003601", "Q20765", "WBGene00003606", "Q9XUK7", "WBGene00003675", "P41830", "WBGene00004786", "P55853", "WBGene00004888", "WBGene00006706", "Q21970", "WBGene00011259", "Q94361", "WBGene00001574" ] }, "reaction_10549535": { "compartment": "compartment_7660", "id": "reaction_10549535", "reactome": "R-CEL-4719424", "name": "PIAS1 SUMOylates THRB with SUMO1.", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10519467", "species_10546081" ], "products": [ "species_10549533", "species_10546073" ], "modifiers": [ [ "species_10528091", "catalyst" ] ], "additional_components": [ "P41830", "WBGene00004786", "Q10902", "WBGene00003601", "Q20765", "WBGene00003606", "Q9XUK7", "WBGene00003675", "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "P55853", "WBGene00004888", "Q20765", "WBGene00003606", "Q9XUK7", "WBGene00003675", "P41830", "WBGene00004786", "Q10902", "WBGene00003601", "WBGene00006706", "Q21970", "WBGene00011259", "Q94361", "WBGene00001574" ] }, "reaction_10554195": { "compartment": "compartment_7660", "id": "reaction_10554195", "reactome": "R-CEL-5649856", "name": "Oxidative damage to the AP site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508796" ], "products": [ "species_10554193" ], "modifiers": [], "additional_components": [ "G5EBR7", "WBGene00001372", "G5EBR7", "WBGene00001372" ] }, "reaction_10508799": { "compartment": "compartment_7660", "id": "reaction_10508799", "reactome": "R-CEL-110359", "name": "APEX1 mediates endonucleolytic cleavage at the 5' side of the AP site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508788" ], "products": [ "species_10508796" ], "modifiers": [ [ "species_10508788", "catalyst" ] ], "additional_components": [ "G5EBR7", "WBGene00001372", "G5EBR7", "WBGene00001372", "G5EBR7", "WBGene00001372" ] }, "reaction_10508673": { "compartment": "compartment_7660", "id": "reaction_10508673", "reactome": "R-CEL-110215", "name": "Cleavage of uracil by UNG glycosylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508666" ], "products": [ "species_10508670", "species_29554" ], "modifiers": [ [ "species_10508666", "catalyst" ] ], "additional_components": [ "Q9U221", "WBGene00013241", "Q9U221", "WBGene00013241", "Q9U221", "WBGene00013241" ] }, "reaction_10508689": { "compartment": "compartment_7660", "id": "reaction_10508689", "reactome": "R-CEL-110224", "name": "Cleavage of thymine glycol by NTHL1 glycosylase ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508684" ], "products": [ "species_10508686", "species_110223" ], "modifiers": [ [ "species_10508684", "catalyst" ] ], "additional_components": [ "P54137", "WBGene00011201", "P54137", "WBGene00011201", "P54137", "WBGene00011201" ] }, "reaction_10508710": { "compartment": "compartment_7660", "id": "reaction_10508710", "reactome": "R-CEL-110229", "name": "Cleavage of formamidopyrimidine (FapyA) by NTHL1 glycosylase ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508707" ], "products": [ "species_10508686", "species_5637659" ], "modifiers": [ [ "species_10508707", "catalyst" ] ], "additional_components": [ "P54137", "WBGene00011201", "P54137", "WBGene00011201", "P54137", "WBGene00011201" ] }, "reaction_10508680": { "compartment": "compartment_7660", "id": "reaction_10508680", "reactome": "R-CEL-110217", "name": "Cleavage of 5-hydroxyluracil by UNG glycosylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508677" ], "products": [ "species_10508670", "species_110216" ], "modifiers": [ [ "species_10508677", "catalyst" ] ], "additional_components": [ "Q9U221", "WBGene00013241", "Q9U221", "WBGene00013241", "Q9U221", "WBGene00013241" ] }, "reaction_10508696": { "compartment": "compartment_7660", "id": "reaction_10508696", "reactome": "R-CEL-110226", "name": "Cleavage of cytosine glycol by NTHL1 glycosylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508693" ], "products": [ "species_10508686", "species_110225" ], "modifiers": [ [ "species_10508693", "catalyst" ] ], "additional_components": [ "P54137", "WBGene00011201", "P54137", "WBGene00011201", "P54137", "WBGene00011201" ] }, "reaction_10508703": { "compartment": "compartment_7660", "id": "reaction_10508703", "reactome": "R-CEL-110227", "name": "Cleavage of dihydrouracil by NTHL1 glycosylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508700" ], "products": [ "species_10508686", "species_30140" ], "modifiers": [ [ "species_10508700", "catalyst" ] ], "additional_components": [ "P54137", "WBGene00011201", "P54137", "WBGene00011201", "P54137", "WBGene00011201" ] }, "reaction_10507554": { "compartment": "compartment_70101", "id": "reaction_10507554", "reactome": "R-CEL-75887", "name": "Conversion of Glycerol to Glycerol-3-phosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_76116" ], "products": [ "species_29370", "species_76114" ], "modifiers": [ [ "species_10507551", "catalyst" ] ], "additional_components": [ "Q21944", "WBGene00020007" ] }, "reaction_10507603": { "compartment": "compartment_70101", "id": "reaction_10507603", "reactome": "R-CEL-75900", "name": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_75967", "species_76103" ], "products": [ "species_549167", "species_76194" ], "modifiers": [ [ "species_10507600", "catalyst" ] ], "additional_components": [ "Q9NCE1", "WBGene00010408" ] }, "reaction_10557589": { "compartment": "compartment_12045", "id": "reaction_10557589", "reactome": "R-CEL-5696119", "name": "AGMO cleaves alkylglycerol into fatty aldehyde and glycerol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29870", "species_5696122", "species_29368" ], "products": [ "species_29356", "species_1497857", "species_76116", "species_5696116" ], "modifiers": [ [ "species_10557586", "catalyst" ] ], "additional_components": [ "WBGene00007210" ] }, "reaction_10507542": { "compartment": "compartment_70101", "id": "reaction_10507542", "reactome": "R-CEL-75886", "name": "glycerol 3-phosphate + acyl-CoA => 1-acylglycerol 3-phosphate + CoASH [mitochondrial membrane-associated]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_75967", "species_76114" ], "products": [ "species_76194", "species_76112" ], "modifiers": [ [ "species_10507537", "catalyst" ] ], "additional_components": [ "WBGene00017261" ] }, "reaction_10527368": { "compartment": "compartment_70101", "id": "reaction_10527368", "reactome": "R-CEL-549192", "name": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_75967", "species_76103" ], "products": [ "species_549167", "species_76194" ], "modifiers": [ [ "species_10527365", "catalyst" ] ], "additional_components": [ "Q9XUW0", "WBGene00010296", "O01881", "WBGene00021818", "Q23067", "WBGene00020910", "Q9N4S3", "WBGene00021818" ] }, "reaction_10507593": { "compartment": "compartment_70101", "id": "reaction_10507593", "reactome": "R-CEL-75899", "name": "1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76108", "species_29356" ], "products": [ "species_29372", "species_76103" ], "modifiers": [ [ "species_10507586", "catalyst" ] ], "additional_components": [ "WBGene00010425" ] }, "reaction_10562170": { "compartment": "compartment_12045", "id": "reaction_10562170", "reactome": "R-CEL-6800334", "name": "MOGAT1,2,3 transfer acyl group from acyl-CoA to 2-acylglycerol to form DAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6800352", "species_1500578" ], "products": [ "species_76103", "species_76194" ], "modifiers": [ [ "species_10562167", "catalyst" ] ], "additional_components": [ "Q9N4S3", "WBGene00021818", "Q9XUW0", "WBGene00010296", "O01881", "WBGene00021818", "Q23067", "WBGene00020910" ] }, "reaction_10523735": { "compartment": "compartment_70101", "id": "reaction_10523735", "reactome": "R-CEL-430311", "name": "Rsu-1 interacts with Pinch1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10523726", "species_10523731" ], "products": [ "species_10523733" ], "modifiers": [], "additional_components": [ "WBGene00007924", "WBGene00006826", "P50464", "WBGene00006826", "Q09497", "WBGene00007924" ] }, "reaction_10524057": { "compartment": "compartment_70101", "id": "reaction_10524057", "reactome": "R-CEL-432946", "name": "PARVB/Affixin interacts with alpha PIX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10516119", "species_10523717" ], "products": [ "species_10524055" ], "modifiers": [], "additional_components": [ "WBGene00010776", "WBGene00003932", "O16785", "WBGene00003932", "Q21430", "WBGene00010776" ] }, "reaction_10523721": { "compartment": "compartment_70101", "id": "reaction_10523721", "reactome": "R-CEL-430308", "name": "PARVB interacts with Alpha-actinin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10523717", "species_10523712" ], "products": [ "species_10523719" ], "modifiers": [], "additional_components": [ "WBGene00003932", "WBGene00000228", "Q23158", "WBGene00000228", "O16785", "WBGene00003932" ] }, "reaction_10512192": { "compartment": "compartment_70101", "id": "reaction_10512192", "reactome": "R-CEL-179467", "name": "GAB1 binds phosphatidylinositol-3,4,5-trisphosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179838", "species_10512121" ], "products": [ "species_10512159" ], "modifiers": [], "additional_components": [ "P29355", "WBGene00004774", "G5EDJ4", "WBGene00004928", "P29355", "WBGene00004774", "G5EDJ4", "WBGene00004928", "species_179838" ] }, "reaction_10512183": { "compartment": "compartment_70101", "id": "reaction_10512183", "reactome": "R-CEL-177939", "name": "PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10512155", "catalyst" ] ], "additional_components": [ "P24348", "WBGene00002299", "G5EDJ4", "WBGene00004928", "P29355", "WBGene00004774", "species_179838", "G5EDP9", "WBGene00000001", "Q94125", "WBGene00000090" ] }, "reaction_10512169": { "compartment": "compartment_70101", "id": "reaction_10512169", "reactome": "R-CEL-177930", "name": "GAB1 phosphorylation by EGFR kinase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10512163" ], "products": [ "species_29370", "species_10512153" ], "modifiers": [ [ "species_10512163", "catalyst" ] ], "additional_components": [ "P29355", "WBGene00004774", "G5EDJ4", "WBGene00004928", "species_179838", "P24348", "WBGene00002299", "P24348", "WBGene00002299", "G5EDJ4", "WBGene00004928", "P29355", "WBGene00004774", "species_179838", "P29355", "WBGene00004774", "G5EDJ4", "WBGene00004928", "species_179838", "P24348", "WBGene00002299" ] }, "reaction_10512123": { "compartment": "compartment_70101", "id": "reaction_10512123", "reactome": "R-CEL-177920", "name": "Binding of GRB2 to GAB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10506871", "species_10512119" ], "products": [ "species_10512121" ], "modifiers": [], "additional_components": [ "WBGene00004774", "WBGene00004928", "P29355", "WBGene00004774", "G5EDJ4", "WBGene00004928" ] }, "reaction_10512157": { "compartment": "compartment_876", "id": "reaction_10512157", "reactome": "R-CEL-177927", "name": "PI3K binds to EGF:EGFR:GRB2:GAB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10506892", "species_10512153" ], "products": [ "species_10512155" ], "modifiers": [], "additional_components": [ "G5EDP9", "WBGene00000001", "Q94125", "WBGene00000090", "P24348", "WBGene00002299", "G5EDJ4", "WBGene00004928", "P29355", "WBGene00004774", "species_179838", "P24348", "WBGene00002299", "G5EDJ4", "WBGene00004928", "P29355", "WBGene00004774", "species_179838", "G5EDP9", "WBGene00000001", "Q94125", "WBGene00000090" ] }, "reaction_10519952": { "compartment": "compartment_876", "id": "reaction_10519952", "reactome": "R-CEL-380905", "name": "Serotonin loaded synaptic vesicle docking and priming", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10516749", "species_10516777", "species_10519865", "species_10519944", "species_10516744", "species_10516631", "species_10516739" ], "products": [ "species_10519946" ], "modifiers": [ [ "species_10519944", "catalyst" ] ], "additional_components": [ "WBGene00006798", "Q21049", "WBGene00006364", "Q22366", "WBGene00006750", "P27715", "WBGene00006752", "Q9N415", "WBGene00006513", "Q94057", "WBGene00044062", "Q95XH1", "WBGene00022077", "G5EBK2", "WBGene00014084", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q19767", "WBGene00004898", "Q9GNP0", "WBGene00000295", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "Q94986", "WBGene00004267", "species_380585", "WBGene00022271", "WBGene00006757", "G5EEN8", "WBGene00006454", "A5PEW5", "WBGene00004364", "G5EEN8", "WBGene00006454", "A5PEW5", "WBGene00004364", "P34815", "WBGene00006757", "Q94057", "WBGene00044062", "Q95XH1", "WBGene00022077", "G5EBK2", "WBGene00014084", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q19767", "WBGene00004898", "Q9GNP0", "WBGene00000295", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "Q94986", "WBGene00004267", "species_380585", "Q9GUM7", "WBGene00022271", "Q21049", "WBGene00006364", "Q22366", "WBGene00006750", "P27715", "WBGene00006752", "Q9N415", "WBGene00006513", "O16000", "WBGene00006798", "Q94057", "WBGene00044062", "Q95XH1", "WBGene00022077", "G5EBK2", "WBGene00014084", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q19767", "WBGene00004898", "Q9GNP0", "WBGene00000295", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "Q94986", "WBGene00004267", "species_380585" ] }, "reaction_10519894": { "compartment": "compartment_374932", "id": "reaction_10519894", "reactome": "R-CEL-380586", "name": "loading of Serotonin in synaptic vesicles", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_209914" ], "products": [ "species_380585" ], "modifiers": [ [ "species_10518406", "catalyst" ] ], "additional_components": [ "WBGene00000295" ] }, "reaction_10519949": { "compartment": "compartment_984", "id": "reaction_10519949", "reactome": "R-CEL-380901", "name": "Release of docked serotonin loaded synaptic vesicle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10519946" ], "products": [ "species_10518827", "species_114523", "species_10516777", "species_10519865", "species_10516825", "species_10516744", "species_10516631", "species_10516823", "species_10516807" ], "modifiers": [ [ "species_10519946", "catalyst" ] ], "additional_components": [ "G5EEN8", "WBGene00006454", "A5PEW5", "WBGene00004364", "P34815", "WBGene00006757", "Q94057", "WBGene00044062", "Q95XH1", "WBGene00022077", "G5EBK2", "WBGene00014084", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q19767", "WBGene00004898", "Q9GNP0", "WBGene00000295", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "Q94986", "WBGene00004267", "species_380585", "Q9GUM7", "WBGene00022271", "Q21049", "WBGene00006364", "Q22366", "WBGene00006750", "P27715", "WBGene00006752", "Q9N415", "WBGene00006513", "O16000", "WBGene00006798", "WBGene00000295", "Q21049", "WBGene00006364", "Q22366", "WBGene00006750", "P27715", "WBGene00006752", "Q9N415", "WBGene00006513", "WBGene00004267", "WBGene00022271", "WBGene00006757", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "G5EEN8", "WBGene00006454", "A5PEW5", "WBGene00004364", "Q94057", "WBGene00044062", "Q95XH1", "WBGene00022077", "G5EBK2", "WBGene00014084", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q19767", "WBGene00004898", "O16000", "WBGene00006798", "G5EEN8", "WBGene00006454", "A5PEW5", "WBGene00004364", "P34815", "WBGene00006757", "Q94057", "WBGene00044062", "Q95XH1", "WBGene00022077", "G5EBK2", "WBGene00014084", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q19767", "WBGene00004898", "Q9GNP0", "WBGene00000295", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "Q94986", "WBGene00004267", "species_380585", "Q9GUM7", "WBGene00022271", "Q21049", "WBGene00006364", "Q22366", "WBGene00006750", "P27715", "WBGene00006752", "Q9N415", "WBGene00006513", "O16000", "WBGene00006798" ] }, "reaction_10522699": { "compartment": "compartment_876", "id": "reaction_10522699", "reactome": "R-CEL-426223", "name": "Cation influx mediated by TRPC3/6/7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426219" ], "products": [ "species_426221" ], "modifiers": [ [ "species_10522694", "catalyst" ] ], "additional_components": [ "species_83910", "species_74016", "species_114632", "species_74016", "species_114632", "species_83910", "Q8I6Y9", "WBGene00006615", "species_114519" ] }, "reaction_10520082": { "compartment": "compartment_876", "id": "reaction_10520082", "reactome": "R-CEL-381668", "name": "cAMP activates EPAC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10520078", "species_30389" ], "products": [ "species_10520080" ], "modifiers": [], "additional_components": [ "WBGene00004255", "species_30389", "P34578", "WBGene00004255" ] }, "reaction_10520163": { "compartment": "compartment_876", "id": "reaction_10520163", "reactome": "R-CEL-381713", "name": "Potassium voltage-gated channels close in reponse to PKA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10520161" ], "products": [ "species_10520161" ], "modifiers": [ [ "species_10508954", "catalyst" ] ], "additional_components": [ "A0A4V0INI0", "WBGene00002242", "H2KZQ6", "WBGene00001374", "J3K003", "WBGene00007862", "Q20381", "WBGene00018402", "Q9XXD1", "WBGene00012967", "U4PLR3", "WBGene00021948", "A0A3B1E007", "WBGene00004793", "G5EC00", "WBGene00008819", "G5EFC3", "WBGene00001202", "A0A4V0INI0", "WBGene00002242", "H2KZQ6", "WBGene00001374", "J3K003", "WBGene00007862", "Q20381", "WBGene00018402", "Q9XXD1", "WBGene00012967", "U4PLR3", "WBGene00021948", "A0A3B1E007", "WBGene00004793", "G5EC00", "WBGene00008819", "G5EFC3", "WBGene00001202", "WBGene00002189" ] }, "reaction_10520051": { "compartment": "compartment_876", "id": "reaction_10520051", "reactome": "R-CEL-381608", "name": "cAMP activates EPAC2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10520047", "species_30389" ], "products": [ "species_10520049" ], "modifiers": [], "additional_components": [ "WBGene00004255", "species_30389", "P34578", "WBGene00004255" ] }, "reaction_10520167": { "compartment": "compartment_70101", "id": "reaction_10520167", "reactome": "R-CEL-381727", "name": "RAP1A exchanges GDP for GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10520165" ], "products": [ "species_29420", "species_10518164" ], "modifiers": [ [ "species_10520049", "catalyst" ], [ "species_10520080", "catalyst" ] ], "additional_components": [ "Q18246", "WBGene00004307", "species_29420", "Q18246", "WBGene00004307", "species_29438", "species_30389", "P34578", "WBGene00004255", "species_30389", "P34578", "WBGene00004255" ] }, "reaction_10520075": { "compartment": "compartment_12045", "id": "reaction_10520075", "reactome": "R-CEL-381644", "name": "ER calcium channels open in response to activated PKA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10520065" ], "products": [ "species_10520073" ], "modifiers": [ [ "species_10508954", "catalyst" ] ], "additional_components": [ "Q9Y0A1", "WBGene00002173", "Q9Y0A1", "WBGene00002173", "species_114520", "WBGene00002189" ] }, "reaction_10507009": { "compartment": "compartment_350", "id": "reaction_10507009", "reactome": "R-CEL-74986", "name": "Elongation of pre-rRNA transcript", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74985", "species_30595" ], "products": [ "species_74985" ], "modifiers": [ [ "species_10506322", "catalyst" ], [ "species_10507007", "catalyst" ] ], "additional_components": [ "species_110614", "species_29358", "species_29494", "species_29438", "P46064", "WBGene00006430", "O01914", "WBGene00017758", "P32085", "WBGene00006542", "Q19826", "WBGene00017830", "Q9UAY9", "WBGene00019275", "Q9U3I0", "WBGene00009078", "G5ED21", "WBGene00012999", "Q9N5K2", "WBGene00019246", "Q95X83", "WBGene00017749", "Q17684", "WBGene00007355", "Q9GR61", "WBGene00021347", "O17587", "WBGene00007616", "Q27493", "WBGene00008781", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "P34618", "WBGene00000414", "P62784", "WBGene00001875", "K7ZUH9", "WBGene00001914", "Q10453", "WBGene00001945" ] }, "reaction_10506324": { "compartment": "compartment_7660", "id": "reaction_10506324", "reactome": "R-CEL-73769", "name": "Loss of Rrn3 from RNA Polymerase I promoter escape complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10506318" ], "products": [ "species_10506238", "species_10506322" ], "modifiers": [], "additional_components": [ "Q19826", "WBGene00017830", "Q9UAY9", "WBGene00019275", "Q9U3I0", "WBGene00009078", "G5ED21", "WBGene00012999", "Q9N5K2", "WBGene00019246", "Q95X83", "WBGene00017749", "Q17684", "WBGene00007355", "Q9GR61", "WBGene00021347", "O17587", "WBGene00007616", "Q27493", "WBGene00008781", "P48322", "WBGene00007980", "P46064", "WBGene00006430", "O01914", "WBGene00017758", "P32085", "WBGene00006542", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "WBGene00007980", "P46064", "WBGene00006430", "O01914", "WBGene00017758", "P32085", "WBGene00006542", "Q19826", "WBGene00017830", "Q9UAY9", "WBGene00019275", "Q9U3I0", "WBGene00009078", "G5ED21", "WBGene00012999", "Q9N5K2", "WBGene00019246", "Q95X83", "WBGene00017749", "Q17684", "WBGene00007355", "Q9GR61", "WBGene00021347", "O17587", "WBGene00007616", "Q27493", "WBGene00008781", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529" ] }, "reaction_10506242": { "compartment": "compartment_7660", "id": "reaction_10506242", "reactome": "R-CEL-73757", "name": "Binding of RRN3 to RNA Polymerase I", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10506238", "species_10506233" ], "products": [ "species_10506240" ], "modifiers": [], "additional_components": [ "WBGene00007980", "Q19826", "WBGene00017830", "Q9UAY9", "WBGene00019275", "Q9U3I0", "WBGene00009078", "G5ED21", "WBGene00012999", "Q9N5K2", "WBGene00019246", "Q95X83", "WBGene00017749", "Q17684", "WBGene00007355", "Q9GR61", "WBGene00021347", "O17587", "WBGene00007616", "Q27493", "WBGene00008781", "Q19826", "WBGene00017830", "Q9UAY9", "WBGene00019275", "Q9U3I0", "WBGene00009078", "G5ED21", "WBGene00012999", "Q9N5K2", "WBGene00019246", "Q95X83", "WBGene00017749", "Q17684", "WBGene00007355", "Q9GR61", "WBGene00021347", "O17587", "WBGene00007616", "Q27493", "WBGene00008781", "P48322", "WBGene00007980" ] }, "reaction_10544853": { "compartment": "compartment_876", "id": "reaction_10544853", "reactome": "R-CEL-2534365", "name": "Slo3 Potassium Transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10544850", "catalyst" ] ], "additional_components": [ "Q95V25", "WBGene00004830" ] }, "reaction_10544843": { "compartment": "compartment_876", "id": "reaction_10544843", "reactome": "R-CEL-2534346", "name": "SPAM1 Binds Hyaluronic Acid", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10544839", "species_1297302" ], "products": [ "species_10544841" ], "modifiers": [], "additional_components": [ "WBGene00011923", "species_1297302", "G5ECE8", "WBGene00011923" ] }, "reaction_10568369": { "compartment": "compartment_161320", "id": "reaction_10568369", "reactome": "R-CEL-8938108", "name": "SERPINB13 binds cathepsin L", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10568365", "species_10568363" ], "products": [ "species_10568367" ], "modifiers": [], "additional_components": [ "Q93512", "WBGene00019986", "O45734", "WBGene00000776", "Q23030", "WBGene00019986", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "A9Z1L1", "WBGene00005648", "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "A9Z1L1", "WBGene00005648", "G5ECY2", "WBGene00005644", "Q93512", "WBGene00019986", "O45734", "WBGene00000776", "Q23030", "WBGene00019986" ] }, "reaction_10568373": { "compartment": "compartment_161320", "id": "reaction_10568373", "reactome": "R-CEL-8938121", "name": "SERPINB13 binds CTSK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10568363", "species_10542848" ], "products": [ "species_10568371" ], "modifiers": [], "additional_components": [ "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "A9Z1L1", "WBGene00005648", "G5ECY2", "WBGene00005644", "O45734", "WBGene00000776", "Q23030", "WBGene00019986", "Q93512", "WBGene00019986", "O45734", "WBGene00000776", "Q23030", "WBGene00019986", "Q93512", "WBGene00019986", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "A9Z1L1", "WBGene00005648", "G5ECY2", "WBGene00005644" ] }, "reaction_10573076": { "compartment": "compartment_459", "id": "reaction_10573076", "reactome": "R-CEL-9674531", "name": "AAMP binds EGFR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10512185", "species_10573072" ], "products": [ "species_10573074" ], "modifiers": [], "additional_components": [ "WBGene00002299", "WBGene00013735", "E0R7L2", "WBGene00013735", "P24348", "WBGene00002299" ] }, "reaction_10512180": { "compartment": "compartment_70101", "id": "reaction_10512180", "reactome": "R-CEL-177938", "name": "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10512175", "species_29438" ], "products": [ "species_29420", "species_10511481" ], "modifiers": [ [ "species_10512177", "catalyst" ] ], "additional_components": [ "species_29420", "P22981", "WBGene00002335", "species_29438", "P22981", "WBGene00002335", "P24348", "WBGene00002299", "P29355", "WBGene00004774", "Q9N5D3", "WBGene00004947" ] }, "reaction_10508553": { "compartment": "compartment_70101", "id": "reaction_10508553", "reactome": "R-CEL-109813", "name": "GRB2-1 binds SOS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10506876", "species_10506871" ], "products": [ "species_10506878" ], "modifiers": [], "additional_components": [ "WBGene00004947", "WBGene00004774", "P29355", "WBGene00004774", "Q9N5D3", "WBGene00004947" ] }, "reaction_10502745": { "compartment": "compartment_70101", "id": "reaction_10502745", "reactome": "R-CEL-69191", "name": "Formation of Cyclin E:Cdk2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502739", "species_10502737" ], "products": [ "species_10502743" ], "modifiers": [], "additional_components": [ "WBGene00000871", "WBGene00019362", "O61847", "WBGene00019362", "O01501", "WBGene00000871" ] }, "reaction_10509929": { "compartment": "compartment_13231", "id": "reaction_10509929", "reactome": "R-CEL-157906", "name": "Translocation of Cyclin E:Cdk2 complex to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502743" ], "products": [ "species_10502749" ], "modifiers": [], "additional_components": [ "O61847", "WBGene00019362", "O01501", "WBGene00000871", "O61847", "WBGene00019362" ] }, "reaction_10502762": { "compartment": "compartment_7660", "id": "reaction_10502762", "reactome": "R-CEL-69199", "name": "Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10502754" ], "products": [ "species_113550", "species_10502749" ], "modifiers": [ [ "species_10502759", "catalyst" ] ], "additional_components": [ "O01501", "WBGene00000871", "O61847", "WBGene00019362", "O61847", "WBGene00019362", "WBGene00000389" ] }, "reaction_10512702": { "compartment": "compartment_7660", "id": "reaction_10512702", "reactome": "R-CEL-188350", "name": "CAK-mediated phosphorylation of Cyclin E:Cdk2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10502749" ], "products": [ "species_113582", "species_10502596" ], "modifiers": [ [ "species_10506279", "catalyst" ] ], "additional_components": [ "O61847", "WBGene00019362", "O01501", "WBGene00000871", "O61847", "WBGene00019362", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408" ] }, "reaction_10546481": { "compartment": "compartment_70101", "id": "reaction_10546481", "reactome": "R-CEL-3204303", "name": "MRE11 binds cytosolic DNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546477", "species_874088" ], "products": [ "species_10546479" ], "modifiers": [], "additional_components": [ "WBGene00003405", "species_874088", "Q23255", "WBGene00003405" ] }, "reaction_10546391": { "compartment": "compartment_70101", "id": "reaction_10546391", "reactome": "R-CEL-3134946", "name": "DDX41 ubiquitination by TRIM21", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546380", "species_10502375", "species_10530724" ], "products": [ "species_10546388" ], "modifiers": [ [ "species_10530724", "catalyst" ] ], "additional_components": [ "WBGene00019245", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "WBGene00021640", "Q9N3T6", "WBGene00021640", "Q9N5K1", "WBGene00019245", "WBGene00021640" ] }, "reaction_10571225": { "compartment": "compartment_70101", "id": "reaction_10571225", "reactome": "R-CEL-9013869", "name": "DDX41 binds bacterial c-di-AMP, c-di-GMP ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546380", "species_8982080" ], "products": [ "species_10571223" ], "modifiers": [], "additional_components": [ "WBGene00019245", "CHEBI:49537", "CHEBI:47037", "CHEBI:49537", "CHEBI:47037", "Q9N5K1", "WBGene00019245" ] }, "reaction_10513873": { "compartment": "compartment_876", "id": "reaction_10513873", "reactome": "R-CEL-198314", "name": "DAG stimulates protein kinase C-delta", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10513858" ], "products": [ "species_10513870", "species_29370" ], "modifiers": [ [ "species_10513858", "catalyst" ], [ "species_112275", "catalyst" ] ], "additional_components": [ "P34885", "WBGene00004032", "P34722", "WBGene00006599", "P34722", "WBGene00006599", "P34885", "WBGene00004032", "P34885", "WBGene00004032", "P34722", "WBGene00006599" ] }, "reaction_10542115": { "compartment": "compartment_876", "id": "reaction_10542115", "reactome": "R-CEL-2029475", "name": "Production of AA by iPLA2 upon FCGR activation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_426925" ], "products": [ "species_140356", "species_428981" ], "modifiers": [ [ "species_10534904", "catalyst" ] ], "additional_components": [ "WBGene00016661" ] }, "reaction_10542106": { "compartment": "compartment_876", "id": "reaction_10542106", "reactome": "R-CEL-2029471", "name": "Hydrolysis of PC to PA by PLD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_429802", "species_29356" ], "products": [ "species_264618", "species_1602448" ], "modifiers": [ [ "species_10542103", "catalyst" ] ], "additional_components": [ "G5EDU3", "WBGene00004040" ] }, "reaction_10541996": { "compartment": "compartment_70101", "id": "reaction_10541996", "reactome": "R-CEL-2029454", "name": "Autophosphorylation of PAK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10541994", "species_113592" ], "products": [ "species_29370", "species_10520664", "species_10521268" ], "modifiers": [ [ "species_10520670", "catalyst" ] ], "additional_components": [ "species_29438", "Q03206", "ced-10", "Q05062", "WBGene00000390", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "species_29438", "Q03206", "ced-10", "Q05062", "WBGene00000390", "Q17850", "WBGene00003911", "G5EGQ3", "WBGene00003144", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911" ] }, "reaction_10530663": { "compartment": "compartment_876", "id": "reaction_10530663", "reactome": "R-CEL-981539", "name": "C3b binds to cell surface", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10510806", "species_983438" ], "products": [ "species_10530661" ], "modifiers": [], "additional_components": [ "K8F7Z5", "WBGene00008735", "Q7YTU0", "WBGene00013969", "K8F7Z5", "WBGene00008735", "Q7YTU0", "WBGene00013969" ] }, "reaction_10511597": { "compartment": "compartment_984", "id": "reaction_10511597", "reactome": "R-CEL-173739", "name": "Spontaneous hydrolysis of C3 thioester", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10510798", "species_109276" ], "products": [ "species_10511595" ], "modifiers": [], "additional_components": [ "K8F7Z5", "WBGene00008735", "Q7YTU0", "WBGene00013969", "K8F7Z5", "WBGene00008735", "Q7YTU0", "WBGene00013969" ] }, "reaction_10530687": { "compartment": "compartment_876", "id": "reaction_10530687", "reactome": "R-CEL-981713", "name": "C4b binds to cell surface", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_983438", "species_10510784" ], "products": [ "species_10530685" ], "modifiers": [], "additional_components": [ "K8F7Z5", "WBGene00008735", "Q7YTU0", "WBGene00013969", "K8F7Z5", "WBGene00008735", "Q7YTU0", "WBGene00013969" ] }, "reaction_10569040": { "compartment": "compartment_876", "id": "reaction_10569040", "reactome": "R-CEL-8951486", "name": "CD46 binds C4b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10530685", "species_10531687" ], "products": [ "species_10569038" ], "modifiers": [], "additional_components": [ "K8F7Z5", "WBGene00008735", "Q7YTU0", "WBGene00013969", "A0A1N7SYP5", "WBGene00009500", "Q18849", "WBGene00009500", "Q22328", "WBGene00002976", "A0A1N7SYP5", "WBGene00009500", "Q18849", "WBGene00009500", "Q22328", "WBGene00002976", "K8F7Z5", "WBGene00008735", "Q7YTU0", "WBGene00013969" ] }, "reaction_10531691": { "compartment": "compartment_876", "id": "reaction_10531691", "reactome": "R-CEL-1006143", "name": "CD46 binds C3b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10531687", "species_10530661" ], "products": [ "species_10531689" ], "modifiers": [], "additional_components": [ "A0A1N7SYP5", "WBGene00009500", "Q18849", "WBGene00009500", "Q22328", "WBGene00002976", "K8F7Z5", "WBGene00008735", "Q7YTU0", "WBGene00013969", "K8F7Z5", "WBGene00008735", "Q7YTU0", "WBGene00013969", "A0A1N7SYP5", "WBGene00009500", "Q18849", "WBGene00009500", "Q22328", "WBGene00002976" ] }, "reaction_10565402": { "compartment": "compartment_984", "id": "reaction_10565402", "reactome": "R-CEL-8852809", "name": "CPN, CPB2 cleave C3a, C5a", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10565379" ], "products": [ "species_10565381" ], "modifiers": [ [ "species_10565399", "catalyst" ] ], "additional_components": [ "K8F7Z5", "WBGene00008735", "Q7YTU0", "WBGene00013969", "K8F7Z5", "WBGene00008735", "Q7YTU0", "WBGene00013969", "Q22825", "WBGene00012073", "O17754", "WBGene00001189", "Q9N5Z3", "WBGene00006593", "Q9TZC6", "WBGene00021984", "G3MU29", "WBGene00021984", "Q9XU75", "WBGene00011235", "G5EC13", "WBGene00021984", "G5EC96", "WBGene00021984", "H2L0D7", "WBGene00021984", "H2L0K5", "WBGene00021984", "Q6A577", "WBGene00021984", "Q9BL88", "WBGene00021984" ] }, "reaction_10545918": { "compartment": "compartment_984", "id": "reaction_10545918", "reactome": "R-CEL-2855047", "name": "Hydrolysis of internal thioester in C4b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_10510784" ], "products": [ "species_10530671" ], "modifiers": [], "additional_components": [ "K8F7Z5", "WBGene00008735", "Q7YTU0", "WBGene00013969", "K8F7Z5", "WBGene00008735", "Q7YTU0", "WBGene00013969" ] }, "reaction_10529380": { "compartment": "compartment_70101", "id": "reaction_10529380", "reactome": "R-CEL-936563", "name": "ISGylation of DDX58", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10529344", "species_10529376" ], "products": [ "species_10529378" ], "modifiers": [], "additional_components": [ "WBGene00008400", "P91057", "WBGene00015842", "Q9BL11", "WBGene00021685", "Q21633", "WBGene00006713", "Q27481", "WBGene00006699", "P91057", "WBGene00015842", "Q9BL11", "WBGene00021685", "Q21633", "WBGene00006713", "Q27481", "WBGene00006699", "Q93413", "WBGene00008400" ] }, "reaction_10529352": { "compartment": "compartment_70101", "id": "reaction_10529352", "reactome": "R-CEL-936390", "name": "CYLD mediated deubiquitination of DDX58 (RIG-I)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10529342" ], "products": [ "species_10502375", "species_10529344" ], "modifiers": [ [ "species_10529349", "catalyst" ] ], "additional_components": [ "WBGene00008400", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "WBGene00008400", "WBGene00009594" ] }, "reaction_10515197": { "compartment": "compartment_70101", "id": "reaction_10515197", "reactome": "R-CEL-202164", "name": "Translocation of PDK1 to Plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10515193", "species_202277" ], "products": [ "species_10515195" ], "modifiers": [], "additional_components": [ "WBGene00021022", "species_202247", "species_179838", "Q9UA62", "WBGene00021022", "species_202247", "species_179838" ] }, "reaction_10515220": { "compartment": "compartment_70101", "id": "reaction_10515220", "reactome": "R-CEL-202328", "name": "Translocation of PKC theta to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10514851", "species_112275" ], "products": [ "species_10515218" ], "modifiers": [], "additional_components": [ "WBGene00006599", "P34722", "WBGene00006599", "species_112275" ] }, "reaction_10545484": { "compartment": "compartment_70101", "id": "reaction_10545484", "reactome": "R-CEL-2730835", "name": "Autophosphorylation of PKC-theta", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10515204" ], "products": [ "species_10545482", "species_29370" ], "modifiers": [], "additional_components": [ "P34722", "WBGene00006599", "species_112275", "species_112275", "P34722", "WBGene00006599" ] }, "reaction_10545501": { "compartment": "compartment_876", "id": "reaction_10545501", "reactome": "R-CEL-2730862", "name": "Autophosphorylation of LYN kinase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10545490" ], "products": [ "species_10545498", "species_29370" ], "modifiers": [ [ "species_10545490", "catalyst" ] ], "additional_components": [ "Q9N3S5", "WBGene00021635", "G5EE56", "WBGene00005077", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q9N3S5", "WBGene00021635", "G5EE56", "WBGene00005077" ] }, "reaction_10560563": { "compartment": "compartment_6799713", "id": "reaction_10560563", "reactome": "R-CEL-6798747", "name": "Exocytosis of tertiary granule membrane proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10560495" ], "products": [ "species_10560561" ], "modifiers": [], "additional_components": [ "G5EE29", "WBGene00021404", "P91448", "WBGene00004149", "Q19377", "WBGene00008731", "Q23141", "WBGene00020972", "A5PEW5", "WBGene00004364", "G5EEN8", "WBGene00006454", "Q20325", "WBGene00018344", "Q9XUK8", "WBGene00012275", "Q19958", "WBGene00006064", "A0AAC1", "WBGene00012424", "Q21557", "WBGene00010888", "Q22799", "WBGene00001005", "Q65XS9", "WBGene00043067", "Q7YTJ8", "WBGene00012425", "A0A1D3PCM0", "WBGene00270320", "G5EDW5", "WBGene00000074", "G5EFD5", "WBGene00006804", "Q19844", "WBGene00270320", "G5EBK2", "WBGene00014084", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q19767", "WBGene00004898", "Q94057", "WBGene00044062", "Q95XH1", "WBGene00022077", "G5EFD9", "WBGene00006324", "Q9TYL9", "WBGene00021292", "Q9XTY9", "WBGene00010993", "O18076", "WBGene00011668", "O44871", "WBGene00019914", "P91214", "WBGene00017199", "Q21146", "WBGene00019328", "Q9N4W4", "WBGene00021602", "Q9N4W5", "WBGene00021603", "G5EDU3", "WBGene00004040", "U4PBV8", "WBGene00019166", "C0HLB3", "WBGene00006911", "C0HLB4", "WBGene00006912", "Q20707", "WBGene00006630", "G4RWX0", "WBGene00006632", "H2L006", "WBGene00006640", "Q22495", "WBGene00006638", "O62466", "WBGene00006631", "G5ECY2", "WBGene00005644", "Q9NEI8", "WBGene00043980", "A0A0S4XR36", "C44E4.1d", "P22981", "WBGene00002335", "Q27874", "WBGene00003930", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "O17599", "WBGene00004308", "Q93874", "WBGene00004276", "O01312", "WBGene00004309", "Q21433", "WBGene00004877", "Q21434", "WBGene00004876", "Q95XG8", "WBGene00004878", "Q23022", "WBGene00006774", "P34446", "WBGene00003929", "C0HLB4", "WBGene00006912", "C0HLB3", "WBGene00006911", "U4PBV8", "WBGene00019166", "Q22799", "WBGene00001005", "Q65XS9", "WBGene00043067", "Q7YTJ8", "WBGene00012425", "A0AAC1", "WBGene00012424", "Q21557", "WBGene00010888", "Q19377", "WBGene00008731", "Q23141", "WBGene00020972", "G5EE29", "WBGene00021404", "P91448", "WBGene00004149", "O18076", "WBGene00011668", "O44871", "WBGene00019914", "P91214", "WBGene00017199", "Q21146", "WBGene00019328", "Q9N4W4", "WBGene00021602", "Q9N4W5", "WBGene00021603", "Q21433", "WBGene00004877", "Q21434", "WBGene00004876", "Q95XG8", "WBGene00004878", "Q9TYL9", "WBGene00021292", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "Q9XTY9", "WBGene00010993", "P22981", "WBGene00002335", "Q93874", "WBGene00004276", "Q19958", "WBGene00006064", "Q23022", "WBGene00006774", "G5ECY2", "WBGene00005644", "O17599", "WBGene00004308", "O01312", "WBGene00004309", "Q9NEI8", "WBGene00043980", "Q95XH1", "WBGene00022077", "G5EBK2", "WBGene00014084", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q19767", "WBGene00004898", "Q94057", "WBGene00044062", "G5EEN8", "WBGene00006454", "A5PEW5", "WBGene00004364", "Q19844", "WBGene00270320", "A0A1D3PCM0", "WBGene00270320", "G5EDW5", "WBGene00000074", "G5EFD5", "WBGene00006804", "O62466", "WBGene00006631", "Q20707", "WBGene00006630", "Q22495", "WBGene00006638", "G4RWX0", "WBGene00006632", "H2L006", "WBGene00006640", "G5EFD9", "WBGene00006324", "G5EDU3", "WBGene00004040", "Q27874", "WBGene00003930", "P34446", "WBGene00003929", "Q20325", "WBGene00018344", "Q9XUK8", "WBGene00012275", "A0A0S4XR36", "C44E4.1d" ] }, "reaction_10561604": { "compartment": "compartment_1470028", "id": "reaction_10561604", "reactome": "R-CEL-6798751", "name": "Exocytosis of azurophil granule lumen proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10559966" ], "products": [ "species_10560050" ], "modifiers": [], "additional_components": [ "G5EFI4", "WBGene00002268", "A0A486WWU7", "WBGene00000110", "O44555", "WBGene00000111", "Q965W1", "WBGene00021486", "G5ED36", "WBGene00004378", "A0A1N7SYP5", "WBGene00009500", "Q18849", "WBGene00009500", "Q22328", "WBGene00002976", "O62403", "WBGene00013782", "Q20748", "WBGene00010015", "P30628", "WBGene00006768", "O17772", "WBGene00003980", "P34446", "WBGene00003929", "G5ECY2", "WBGene00005644", "Q03206", "ced-10", "G5ED34", "WBGene00001007", "Q94148", "WBGene00004273", "Q19479", "WBGene00008848", "Q7JP75", "WBGene00000872", "E6N0V1", "WBGene00018819", "Q8MXS1", "WBGene00004277", "G5ECX0", "WBGene00002252", "Q94986", "WBGene00004267", "P55163", "WBGene00001580", "P91857", "WBGene00004268", "Q22601", "WBGene00000161", "Q9NEI8", "WBGene00043980", "P34213", "WBGene00004269", "Q22782", "WBGene00004270", "A9Z1L1", "WBGene00005648", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "Q23146", "WBGene00004271", "Q22038", "WBGene00004357", "Q18673", "WBGene00013926", "P91214", "WBGene00017199", "Q21146", "WBGene00019328", "Q9N4W4", "WBGene00021602", "Q9N4W5", "WBGene00021603", "O18076", "WBGene00011668", "O44871", "WBGene00019914", "Q22531", "WBGene00011803", "Q9TYL9", "WBGene00021292", "O62403", "WBGene00013782", "Q94148", "WBGene00004273", "Q8MXS1", "WBGene00004277", "P91857", "WBGene00004268", "P34213", "WBGene00004269", "Q22782", "WBGene00004270", "O18076", "WBGene00011668", "O44871", "WBGene00019914", "P91214", "WBGene00017199", "Q21146", "WBGene00019328", "Q9N4W4", "WBGene00021602", "Q9N4W5", "WBGene00021603", "Q23146", "WBGene00004271", "Q9TYL9", "WBGene00021292", "Q22038", "WBGene00004357", "Q965W1", "WBGene00021486", "Q22531", "WBGene00011803", "Q20748", "WBGene00010015", "Q22328", "WBGene00002976", "A0A1N7SYP5", "WBGene00009500", "Q18849", "WBGene00009500", "P30628", "WBGene00006768", "A0A486WWU7", "WBGene00000110", "O44555", "WBGene00000111", "G5ECY2", "WBGene00005644", "G5ED34", "WBGene00001007", "Q9NEI8", "WBGene00043980", "Q19479", "WBGene00008848", "Q7JP75", "WBGene00000872", "E6N0V1", "WBGene00018819", "P55163", "WBGene00001580", "P34446", "WBGene00003929", "O17772", "WBGene00003980", "Q03206", "ced-10", "G5ED36", "WBGene00004378", "Q19651", "WBGene00005649", "A9Z1L1", "WBGene00005648", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q22601", "WBGene00000161", "G5ECX0", "WBGene00002252", "Q94986", "WBGene00004267", "Q18673", "WBGene00013926", "G5EFI4", "WBGene00002268" ] }, "reaction_10559815": { "compartment": "compartment_6798757", "id": "reaction_10559815", "reactome": "R-CEL-6798739", "name": "Exocytosis of azurophil granule membrane proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10559673" ], "products": [ "species_10559813" ], "modifiers": [], "additional_components": [ "Q22630", "WBGene00011879", "E7EM30", "WBGene00206373", "Q19175", "WBGene00008560", "O17373", "WBGene00020471", "Q23534", "WBGene00022770", "Q19390", "WBGene00017427", "Q95PW2", "WBGene00206373", "P90949", "WBGene00011262", "Q19460", "WBGene00008801", "Q09448", "WBGene00007328", "Q95QK6", "WBGene00008804", "Q19461", "WBGene00008802", "Q9BL40", "WBGene00022181", "Q09451", "WBGene00007331", "Q20662", "WBGene00018696", "A0A061AJ50", "WBGene00206373", "Q10944", "WBGene00015161", "E7EM29", "WBGene00016152", "Q9GUF1", "WBGene00022246", "Q22525", "WBGene00004023", "Q9GUF2", "WBGene00022245", "Q19076", "WBGene00004020", "Q94986", "WBGene00004267", "Q95XH1", "WBGene00022077", "G5EBK2", "WBGene00014084", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q19767", "WBGene00004898", "Q94057", "WBGene00044062", "Q01608", "WBGene00004958", "O02100", "WBGene00001985", "P52166", "WBGene00004769", "Q9XXA4", "WBGene00007067", "Q19958", "WBGene00006064", "P91857", "WBGene00004268", "Q9U280", "WBGene00013034", "P34676", "WBGene00022801", "Q18864", "WBGene00004788", "G5EDC6", "WBGene00000192", "Q18276", "WBGene00004995", "Q18246", "WBGene00004307", "O76735", "WBGene00004912", "Q11117", "WBGene00003053", "Q9GYK0", "WBGene00015471", "H2KZR1", "WBGene00019780", "P83386", "WBGene00019780", "Q21228", "WBGene00019780", "D9N147", "WBGene00019780", "P83387", "WBGene00019780", "Q18582", "WBGene00019780", "P83351", "WBGene00019305", "G5ED36", "WBGene00004378", "E5QCE7", "WBGene00001032", "Q95QX5", "WBGene00015561", "P45971", "WBGene00011638", "C0HLB3", "WBGene00006911", "C0HLB4", "WBGene00006912", "Q93324", "WBGene00007904", "O76663", "WBGene00015246", "P34669", "WBGene00022793", "P91245", "WBGene00017385", "Q9BL33", "WBGene00022169", "Q23316", "WBGene00000148", "Q9XWC5", "WBGene00019346", "Q23151", "WBGene00012224", "H2L0H3", "WBGene00019946", "Q19635", "WBGene00008969", "Q17441", "WBGene00006646", "C0HLB4", "WBGene00006912", "C0HLB3", "WBGene00006911", "P52166", "WBGene00004769", "Q01608", "WBGene00004958", "O02100", "WBGene00001985", "Q9XWC5", "WBGene00019346", "H2L0H3", "WBGene00019946", "Q19635", "WBGene00008969", "Q23151", "WBGene00012224", "G5EDC6", "WBGene00000192", "Q9GYK0", "WBGene00015471", "Q11117", "WBGene00003053", "E5QCE7", "WBGene00001032", "P34669", "WBGene00022793", "Q19958", "WBGene00006064", "Q9U280", "WBGene00013034", "P91245", "WBGene00017385", "Q17441", "WBGene00006646", "Q93324", "WBGene00007904", "Q09448", "WBGene00007328", "Q9GUF2", "WBGene00022245", "Q09451", "WBGene00007331", "Q10944", "WBGene00015161", "Q19076", "WBGene00004020", "Q19175", "WBGene00008560", "Q19390", "WBGene00017427", "Q19460", "WBGene00008801", "Q19461", "WBGene00008802", "Q20662", "WBGene00018696", "Q22525", "WBGene00004023", "Q22630", "WBGene00011879", "A0A061AJ50", "WBGene00206373", "Q23534", "WBGene00022770", "E7EM29", "WBGene00016152", "Q95PW2", "WBGene00206373", "E7EM30", "WBGene00206373", "Q95QK6", "WBGene00008804", "O17373", "WBGene00020471", "Q9BL40", "WBGene00022181", "P90949", "WBGene00011262", "Q9GUF1", "WBGene00022246", "Q95XH1", "WBGene00022077", "G5EBK2", "WBGene00014084", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q19767", "WBGene00004898", "Q94057", "WBGene00044062", "P34676", "WBGene00022801", "Q23316", "WBGene00000148", "Q18276", "WBGene00004995", "D9N147", "WBGene00019780", "H2KZR1", "WBGene00019780", "P83386", "WBGene00019780", "P83387", "WBGene00019780", "Q18582", "WBGene00019780", "Q21228", "WBGene00019780", "P45971", "WBGene00011638", "G5ED36", "WBGene00004378", "Q94986", "WBGene00004267", "O76663", "WBGene00015246", "Q9XXA4", "WBGene00007067", "Q18246", "WBGene00004307", "Q9BL33", "WBGene00022169", "P91857", "WBGene00004268", "Q18864", "WBGene00004788", "P83351", "WBGene00019305", "O76735", "WBGene00004912", "Q95QX5", "WBGene00015561" ] }, "reaction_10562822": { "compartment": "compartment_984", "id": "reaction_10562822", "reactome": "R-CEL-6800434", "name": "Exocytosis of ficolin-rich granule lumen proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10562768" ], "products": [ "species_10562820" ], "modifiers": [], "additional_components": [ "O45686", "WBGene00010769", "Q27483", "WBGene00008230", "Q9TZL8", "WBGene00022199", "Q21966", "WBGene00000217", "P43510", "WBGene00000786", "Q8MYL7", "WBGene00013220", "O62334", "WBGene00011050", "Q18688", "WBGene00000915", "P28548", "WBGene00002196", "O61792", "WBGene00004464", "P09446", "WBGene00002005", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "P04630", "WBGene00000285", "Q09665", "WBGene00006583", "A0A2C9C3L3", "WBGene00020378", "Q09980", "WBGene00017394", "G5EDZ8", "WBGene00000288", "Q11083", "WBGene00020378", "G5EEG0", "WBGene00000286", "Q18136", "WBGene00006861", "G5EF37", "WBGene00003934", "Q94288", "WBGene00000287", "Q20585", "WBGene00004463", "G5EC99", "WBGene00009691", "G5ECU5", "WBGene00009691", "O45246", "WBGene00002026", "Q04908", "WBGene00004460", "Q9GZH5", 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"WBGene00011050", "O61792", "WBGene00004464", "Q20585", "WBGene00004463" ] }, "reaction_10561224": { "compartment": "compartment_6799371", "id": "reaction_10561224", "reactome": "R-CEL-6798749", "name": "Exocytosis of specific granule lumen proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10561178" ], "products": [ "species_10561222" ], "modifiers": [], "additional_components": [ "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "Q21182", "WBGene00194737", "O61967", "WBGene00002632", "Q21408", "WBGene00004951", "O44131", "WBGene00015620", "G5EBT7", "WBGene00000583", "G5EGP1", "WBGene00006845", "Q19137", "WBGene00008543", "G5EFB5", "WBGene00000777", "G5EC24", "WBGene00004214", "O01824", "WBGene00019008", "G5EBS5", "WBGene00000089", "Q19202", "WBGene00017244", "Q10953", "WBGene00006943", "Q18825", "WBGene00000238", "O44326", "WBGene00001979", "H2KZY5", "WBGene00018533", "Q11174", "WBGene00000503", "Q93565", "WBGene00006578", "P19826", "WBGene00000942", "O44518", "WBGene00001579", "Q19349", "WBGene00017376", "Q966Q0", "WBGene00017376", "G5EBT9", "WBGene00010418", "Q9N5N3", "WBGene00019178", "G5EEN3", "WBGene00000419", "O45539", "WBGene00005078", "Q10011", "WBGene00020563", "Q304D5", "WBGene00016278", "A0A1X7RC97", "WBGene00020658", "Q9BIB8", "WBGene00002075", "Q21966", "WBGene00000217", "O62349", "WBGene00011253", "Q93377", "WBGene00008093", "Q09498", "WBGene00008051", "Q18740", "WBGene00008231", "Q9U2X1", "WBGene00013764", "Q9XWA4", "WBGene00013764", "Q9XXQ7", "WBGene00013764", "G5EGP8", "WBGene00000788", "P92005", "WBGene00000789", "Q304D5", "WBGene00016278", "Q21182", "WBGene00194737", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "Q9BIB8", "WBGene00002075", "O61967", "WBGene00002632", "G5EBS5", "WBGene00000089", "Q93565", "WBGene00006578", "H2KZY5", "WBGene00018533", "Q21408", "WBGene00004951", "O44518", "WBGene00001579", "P19826", "WBGene00000942", "Q21966", "WBGene00000217", "O44326", "WBGene00001979", "Q10953", "WBGene00006943", "Q18825", "WBGene00000238", "O44131", "WBGene00015620", "O01824", "WBGene00019008", "A0A1X7RC97", "WBGene00020658", "O45539", "WBGene00005078", "G5EBT9", "WBGene00010418", "Q19202", "WBGene00017244", "G5EC24", "WBGene00004214", "Q10011", "WBGene00020563", "Q9XWA4", "WBGene00013764", "Q9XXQ7", "WBGene00013764", "G5EGP8", "WBGene00000788", "P92005", "WBGene00000789", "Q18740", "WBGene00008231", "Q9U2X1", "WBGene00013764", "G5EBT7", "WBGene00000583", "G5EGP1", "WBGene00006845", "Q19137", "WBGene00008543", "Q19349", "WBGene00017376", "Q966Q0", "WBGene00017376", "G5EFB5", "WBGene00000777", "Q9N5N3", "WBGene00019178", "O62349", "WBGene00011253", "Q11174", "WBGene00000503", "Q09498", "WBGene00008051", "Q93377", "WBGene00008093", "G5EEN3", "WBGene00000419" ] }, "reaction_10560312": { "compartment": "compartment_6800173", "id": "reaction_10560312", "reactome": "R-CEL-6798745", "name": "Exocytosis of tertiary granule lumen proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10560232" ], "products": [ "species_10560310" ], "modifiers": [], "additional_components": [ "Q20587", "WBGene00044310", "Q22993", "WBGene00018811", "Q4W5T6", "WBGene00044310", "O62349", "WBGene00011253", "U4PBQ7", "WBGene00015250", "Q20911", "WBGene00013855", "A8WFK8", "WBGene00016619", "O45686", "WBGene00010769", "Q9N5N3", "WBGene00019178", "H2KZY5", "WBGene00018533", "Q19349", "WBGene00017376", "Q966Q0", "WBGene00017376", "Q19202", "WBGene00017244", "Q11174", "WBGene00000503", "G5EC24", "WBGene00004214", "G5EFB5", "WBGene00000777", "Q21408", "WBGene00004951", "O44518", "WBGene00001579", "Q21966", "WBGene00000217", "H9G2T4", "WBGene00010317", "G5EBT9", "WBGene00010418", "O45734", "WBGene00000776", "Q23030", "WBGene00019986", "Q93512", "WBGene00019986", "G5ECM9", "WBGene00000534", "Q9U204", "WBGene00013323", "Q20628", "WBGene00000392", "Q19137", "WBGene00008543", "G5EBT7", "WBGene00000583", "G5EGP1", "WBGene00006845", "Q9XUT0", "WBGene00010664", "O16453", "WBGene00001500", "Q9TYS3", "WBGene00001501", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "Q21182", "WBGene00194737", "P54216", "WBGene00011474", "P46563", "WBGene00017166", "Q21742", "WBGene00019890", "G5EFT4", "WBGene00016589", "Q09498", "WBGene00008051", "Q93377", "WBGene00008093", "G5ECM9", "WBGene00000534", "Q21182", "WBGene00194737", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "Q9XUT0", "WBGene00010664", "O16453", "WBGene00001500", "Q9TYS3", "WBGene00001501", "H2KZY5", "WBGene00018533", "O44518", "WBGene00001579", "Q21408", "WBGene00004951", "O45734", "WBGene00000776", "Q23030", "WBGene00019986", "Q93512", "WBGene00019986", "Q9U204", "WBGene00013323", "G5EFT4", "WBGene00016589", "Q21966", "WBGene00000217", "H9G2T4", "WBGene00010317", "Q21742", "WBGene00019890", "A8WFK8", "WBGene00016619", "Q20911", "WBGene00013855", "Q20587", "WBGene00044310", "Q22993", "WBGene00018811", "Q4W5T6", "WBGene00044310", "G5EBT9", "WBGene00010418", "O45686", "WBGene00010769", "P46563", "WBGene00017166", "P54216", "WBGene00011474", "Q19202", "WBGene00017244", "G5EC24", "WBGene00004214", "Q11174", "WBGene00000503", "U4PBQ7", "WBGene00015250", "G5EBT7", "WBGene00000583", "G5EGP1", "WBGene00006845", "Q19137", "WBGene00008543", "Q19349", "WBGene00017376", "Q966Q0", "WBGene00017376", "G5EFB5", "WBGene00000777", "Q9N5N3", "WBGene00019178", "O62349", "WBGene00011253", "Q09498", "WBGene00008051", "Q93377", "WBGene00008093", "Q20628", "WBGene00000392" ] }, "reaction_10562427": { "compartment": "compartment_6800424", "id": "reaction_10562427", "reactome": "R-CEL-6800426", "name": "Exocytosis of ficolin-rich granule membrane proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10562381" ], "products": [ "species_10562425" ], "modifiers": [], "additional_components": [ "A9Z1L1", "WBGene00005648", "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "Q19479", "WBGene00008848", "Q7JP75", "WBGene00000872", "E6N0V1", "WBGene00018819", "A0A1D3PCM0", "WBGene00270320", "G5EDW5", "WBGene00000074", "G5EFD5", "WBGene00006804", "Q19844", "WBGene00270320", "A0A0S4XR36", "C44E4.1d", "O45359", "WBGene00020195", "Q17540", "WBGene00020195", "Q22129", "WBGene00020195", "G5ECX0", "WBGene00002252", "Q21146", "WBGene00019328", "Q9N4W4", "WBGene00021602", "Q9N4W5", "WBGene00021603", "O18076", "WBGene00011668", "O44871", "WBGene00019914", "P91214", "WBGene00017199", "Q19833", "WBGene00017837", "P55163", "WBGene00001580", "A0A1N7SYP5", "WBGene00009500", "Q18849", "WBGene00009500", "Q22328", "WBGene00002976", "Q27874", "WBGene00003930", "G5EFI4", "WBGene00002268", "C0HLB3", "WBGene00006911", "C0HLB4", "WBGene00006912", "Q03206", "ced-10", "Q22601", "WBGene00000161", "P34676", "WBGene00022801", "Q22038", "WBGene00004357", "G5EGJ5", "WBGene00002048", "Q95XG8", "WBGene00004878", "Q21433", "WBGene00004877", "Q21434", "WBGene00004876", "Q11117", "WBGene00003053", "Q9GYK0", "WBGene00015471", "Q53U87", "WBGene00004732", "G5EDC6", "WBGene00000192", "G5EE29", "WBGene00021404", "P91448", "WBGene00004149", "Q19377", "WBGene00008731", "Q23141", "WBGene00020972", "Q20748", "WBGene00010015", "A0AAC1", "WBGene00012424", "Q21557", "WBGene00010888", "Q22799", "WBGene00001005", "Q65XS9", "WBGene00043067", "Q7YTJ8", "WBGene00012425", "Q9NEI8", "WBGene00043980", "P30628", "WBGene00006768", "Q19319", "WBGene00000396", "B2MZD0", "WBGene00006916", "G5EEK9", "WBGene00006914", "G5EGP4", "WBGene00006915", "Q9U308", "WBGene00002175", "O44873", "WBGene00019915", "P34446", "WBGene00003929", "G5ED34", "WBGene00001007", "Q9TYL9", "WBGene00021292", "Q9XTY9", "WBGene00010993", "A0A1N7SYP3", "WBGene00006876", "C0HLB4", "WBGene00006912", "C0HLB3", "WBGene00006911", "A0A1N7SYP3", "WBGene00006876", "G5EEK9", "WBGene00006914", "G5EGP4", "WBGene00006915", "P30628", "WBGene00006768", "B2MZD0", "WBGene00006916", "Q22799", "WBGene00001005", "Q65XS9", "WBGene00043067", "Q7YTJ8", "WBGene00012425", "A0AAC1", "WBGene00012424", "Q21557", "WBGene00010888", "Q19377", "WBGene00008731", "Q23141", "WBGene00020972", "G5EE29", "WBGene00021404", "P91448", "WBGene00004149", "G5EDC6", "WBGene00000192", "Q22038", "WBGene00004357", "O18076", "WBGene00011668", "O44871", "WBGene00019914", "P91214", "WBGene00017199", "Q21146", "WBGene00019328", "Q9N4W4", "WBGene00021602", "Q9N4W5", "WBGene00021603", "Q21433", "WBGene00004877", "Q21434", "WBGene00004876", "Q95XG8", "WBGene00004878", "Q9TYL9", "WBGene00021292", "Q9XTY9", "WBGene00010993", "Q20748", "WBGene00010015", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "A9Z1L1", "WBGene00005648", "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "Q11117", "WBGene00003053", "Q9GYK0", "WBGene00015471", "G5ED34", "WBGene00001007", "Q19319", "WBGene00000396", "Q9NEI8", "WBGene00043980", "Q19479", "WBGene00008848", "Q7JP75", "WBGene00000872", "E6N0V1", "WBGene00018819", "P55163", "WBGene00001580", "P34676", "WBGene00022801", "Q19844", "WBGene00270320", "A0A1D3PCM0", "WBGene00270320", "G5EDW5", "WBGene00000074", "G5EFD5", "WBGene00006804", "P34446", "WBGene00003929", "Q27874", "WBGene00003930", "Q53U87", "WBGene00004732", "G5EGJ5", "WBGene00002048", "Q03206", "ced-10", "O44873", "WBGene00019915", "Q22601", "WBGene00000161", "G5ECX0", "WBGene00002252", "A0A0S4XR36", "C44E4.1d", "O45359", "WBGene00020195", "Q17540", "WBGene00020195", "Q22129", "WBGene00020195", "A0A1N7SYP5", "WBGene00009500", "Q18849", "WBGene00009500", "Q22328", "WBGene00002976", "Q19833", "WBGene00017837", "Q9U308", "WBGene00002175", "G5EFI4", "WBGene00002268" ] }, "reaction_10562074": { "compartment": "compartment_6799351", "id": "reaction_10562074", "reactome": "R-CEL-6799350", "name": "Exocytosis of specific granule membrane proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10562030" ], "products": [ "species_10562072" ], "modifiers": [], "additional_components": [ "G5EC93", "WBGene00022014", "O16547", "WBGene00022014", "O44616", "WBGene00022014", "O44827", "WBGene00019207", "O45920", "WBGene00022014", "Q11114", "WBGene00022014", "Q19376", "WBGene00022014", "Q20734", "WBGene00022014", "Q23535", "WBGene00006865", "Q23626", "WBGene00022014", "Q95QY6", "WBGene00022014", "Q9GPA2", "WBGene00022014", "Q9N309", "WBGene00022014", "Q9U2K5", "WBGene00022014", "Q9XU83", "WBGene00022014", "Q9XVL3", "WBGene00022014", "G5EED5", "WBGene00004743", "Q9N4W4", "WBGene00021602", "Q9N4W5", "WBGene00021603", "O18076", "WBGene00011668", "O44871", "WBGene00019914", "P91214", "WBGene00017199", "Q21146", "WBGene00019328", "A5PEW5", "WBGene00004364", "Q20325", "WBGene00018344", "Q9XUK8", "WBGene00012275", "G5EGJ9", "WBGene00009717", "Q9NCE1", "WBGene00010408", "G5EEN8", "WBGene00006454", 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"WBGene00012224", "Q20734", "WBGene00022014", "O16547", "WBGene00022014", "Q9XU83", "WBGene00022014", "Q23535", "WBGene00006865", "O44616", "WBGene00022014", "Q9XVL3", "WBGene00022014", "Q23626", "WBGene00022014", "O44827", "WBGene00019207", "Q95QY6", "WBGene00022014", "O45920", "WBGene00022014", "Q9GPA2", "WBGene00022014", "Q11114", "WBGene00022014", "Q9N309", "WBGene00022014", "Q19376", "WBGene00022014", "G5EC93", "WBGene00022014", "Q9U2K5", "WBGene00022014", "Q19377", "WBGene00008731", "Q23141", "WBGene00020972", "G5EE29", "WBGene00021404", "P91448", "WBGene00004149", "Q9N2U6", "WBGene00022402", "Q22267", "WBGene00011543", "Q8WQG5", "WBGene00007390", "P35602", "WBGene00006829", "Q19958", "WBGene00006064", "E5QCE7", "WBGene00001032", "Q23022", "WBGene00006774", "A0A486WWU7", "WBGene00000110", "O44555", "WBGene00000111", "Q9U280", "WBGene00013034", "G5EC63", "WBGene00013197", "O44186", "WBGene00017996", "O01312", "WBGene00004309", "O17599", "WBGene00004308", "Q9NCE1", "WBGene00010408", "G5EGJ9", "WBGene00009717", "Q9NEI8", "WBGene00043980", "Q95XH1", "WBGene00022077", "G5EBK2", "WBGene00014084", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q19767", "WBGene00004898", "Q94057", "WBGene00044062", "Q19878", "WBGene00009218", "Q18916", "WBGene00017012", "G5EEN8", "WBGene00006454", "A5PEW5", "WBGene00004364", "Q19844", "WBGene00270320", "A0A1D3PCM0", "WBGene00270320", "G5EDW5", "WBGene00000074", "G5EFD5", "WBGene00006804", "Q19930", "WBGene00017947", "O62466", "WBGene00006631", "Q20707", "WBGene00006630", "Q22495", "WBGene00006638", "G4RWX0", "WBGene00006632", "H2L006", "WBGene00006640", "Q10956", "WBGene00015148", "G5EFD9", "WBGene00006324", "G5EDU3", "WBGene00004040", "Q95QG1", "WBGene00018423", "Q27874", "WBGene00003930", "A0A4V0IKG6", "WBGene00007287", "D9N147", "WBGene00019780", "H2KZR1", "WBGene00019780", "P83386", "WBGene00019780", "P83387", "WBGene00019780", "Q18582", "WBGene00019780", "Q21228", "WBGene00019780", "Q9XXA4", "WBGene00007067", "Q18246", "WBGene00004307", "Q9N3Y5", "WBGene00021537", "Q20241", "WBGene00006470", "Q8MQ55", "WBGene00009580", "P34462", "WBGene00010130", "Q20325", "WBGene00018344", "Q9XUK8", "WBGene00012275", "G5EED5", "WBGene00004743", "P91214", "WBGene00017199", "Q21146", "WBGene00019328", "Q9N4W4", "WBGene00021602", "Q9N4W5", "WBGene00021603", "O18076", "WBGene00011668", "O44871", "WBGene00019914", "A0A0S4XR36", "C44E4.1d", "P34446", "WBGene00003929", "Q95QX5", "WBGene00015561", "O44836", "WBGene00019212" ] }, "reaction_10552610": { "compartment": "compartment_876", "id": "reaction_10552610", "reactome": "R-CEL-5607746", "name": "PKC-delta is activated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10552599" ], "products": [ "species_10552608" ], "modifiers": [], "additional_components": [ "species_112275", "P34722", "WBGene00006599", "species_112275", "P34722", "WBGene00006599" ] }, "reaction_10552614": { "compartment": "compartment_876", "id": "reaction_10552614", "reactome": "R-CEL-5607755", "name": "p-Y753,Y759-PLCG2 translocates from cytosol to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10552612" ], "products": [ "species_10552603" ], "modifiers": [], "additional_components": [ "WBGene00004038", "WBGene00004038" ] }, "reaction_10552601": { "compartment": "compartment_876", "id": "reaction_10552601", "reactome": "R-CEL-5607734", "name": "PKC-delta translocates to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10550601", "species_112275" ], "products": [ "species_10552599" ], "modifiers": [], "additional_components": [ "WBGene00006599", "species_112275", "P34722", "WBGene00006599" ] }, "reaction_10552606": { "compartment": "compartment_876", "id": "reaction_10552606", "reactome": "R-CEL-5607735", "name": "p-Y753,Y759-PLCG2 hydrolyses PIP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_179856" ], "products": [ "species_114520", "species_112275" ], "modifiers": [ [ "species_10552603", "catalyst" ] ], "additional_components": [ "WBGene00004038" ] }, "reaction_10553376": { "compartment": "compartment_876", "id": "reaction_10553376", "reactome": "R-CEL-5624486", "name": "SFKs phosphorylates RAF1 on Y340,Y341", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10553365" ], "products": [ "species_10553371", "species_29370" ], "modifiers": [ [ "species_10553373", "catalyst" ] ], "additional_components": [ "Q07292", "WBGene00003030", "species_29438", "P22981", "WBGene00002335", "Q07292", "WBGene00003030", "species_29438", "P22981", "WBGene00002335", "Q9N3S5", "WBGene00021635", "G5EE56", "WBGene00005077" ] }, "reaction_10553381": { "compartment": "compartment_876", "id": "reaction_10553381", "reactome": "R-CEL-5624492", "name": "PAK phosphorylates p21 RAF1 on S338", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10553378" ], "products": [ "species_29370", "species_10553365" ], "modifiers": [ [ "species_10520688", "catalyst" ] ], "additional_components": [ "species_29438", "P22981", "WBGene00002335", "Q07292", "WBGene00003030", "Q07292", "WBGene00003030", "species_29438", "P22981", "WBGene00002335", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911" ] }, "reaction_10553383": { "compartment": "compartment_876", "id": "reaction_10553383", "reactome": "R-CEL-5624494", "name": "RAF1 binds p21 RAS:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10521086", "species_10511481" ], "products": [ "species_10553378" ], "modifiers": [], "additional_components": [ "WBGene00003030", "species_29438", "P22981", "WBGene00002335", "species_29438", "P22981", "WBGene00002335", "Q07292", "WBGene00003030" ] }, "reaction_10565907": { "compartment": "compartment_984", "id": "reaction_10565907", "reactome": "R-CEL-8862771", "name": "PLA2G2A binds bacterial phospholipids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10535794", "species_8931784" ], "products": [ "species_10565905" ], "modifiers": [], "additional_components": [ "O16654", "WBGene00044468", "Q17790", "WBGene00044468", "Q3V5J7", "WBGene00044468", "species_74016", "CHEBI:62643", "CHEBI:62643", "O16654", "WBGene00044468", "Q17790", "WBGene00044468", "Q3V5J7", "WBGene00044468", "species_74016" ] }, "reaction_10562932": { "compartment": "compartment_984", "id": "reaction_10562932", "reactome": "R-CEL-6801762", "name": "REG3A oligomerize to form a pore complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10562926" ], "products": [ "species_10562930" ], "modifiers": [ [ "species_166005", "inhibitor" ] ], "additional_components": [ "CHEBI:62643", "G4RY15", "WBGene00015631", "P34472", "WBGene00010228", "Q22591", "WBGene00020585", "CHEBI:62643", "G4RY15", "WBGene00015631", "P34472", "WBGene00010228", "Q22591", "WBGene00020585" ] }, "reaction_10562950": { "compartment": "compartment_984", "id": "reaction_10562950", "reactome": "R-CEL-6801776", "name": "REG3A binds bacterial phospholipids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10562924", "species_8931784" ], "products": [ "species_10562926" ], "modifiers": [], "additional_components": [ "G4RY15", "WBGene00015631", "P34472", "WBGene00010228", "Q22591", "WBGene00020585", "CHEBI:62643", "CHEBI:62643", "G4RY15", "WBGene00015631", "P34472", "WBGene00010228", "Q22591", "WBGene00020585" ] }, "reaction_10563816": { "compartment": "compartment_984", "id": "reaction_10563816", "reactome": "R-CEL-6810724", "name": "PI3 binds the bacterial surface", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6803081", "species_10563812" ], "products": [ "species_10563814" ], "modifiers": [], "additional_components": [ "O44131", "WBGene00015620", "O44131", "WBGene00015620", "species_166005" ] }, "reaction_10562954": { "compartment": "compartment_984", "id": "reaction_10562954", "reactome": "R-CEL-6801808", "name": "REG3A,REG3G binds bacterial peptidoglycan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10562924", "species_6789198" ], "products": [ "species_10562952" ], "modifiers": [], "additional_components": [ "G4RY15", "WBGene00015631", "P34472", "WBGene00010228", "Q22591", "WBGene00020585", "species_6789198", "G4RY15", "WBGene00015631", "P34472", "WBGene00010228", "Q22591", "WBGene00020585" ] }, "reaction_10563166": { "compartment": "compartment_984", "id": "reaction_10563166", "reactome": "R-CEL-6807585", "name": "BPI binds LPS on the bacterial surface", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6803081", "species_10510721" ], "products": [ "species_10563164" ], "modifiers": [], "additional_components": [ "WBGene00020563", "Q10011", "WBGene00020563", "species_166005" ] }, "reaction_10532731": { "compartment": "compartment_876", "id": "reaction_10532731", "reactome": "R-CEL-1296039", "name": "Activation of Ca2+ activated Potassium channels with small conductance", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10532728", "catalyst" ] ], "additional_components": [ "Q11122", "WBGene00015387", "V6CLK4", "WBGene00008570", "G5EFI1", "WBGene00007176", "O17697", "WBGene00008265" ] }, "reaction_10532702": { "compartment": "compartment_876", "id": "reaction_10532702", "reactome": "R-CEL-1296035", "name": "Activation of Ca2+ activated Potassium channels with Intermediate conductance", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10532699", "catalyst" ] ], "additional_components": [ "Q11122", "WBGene00015387", "V6CLK4", "WBGene00008570", "G5EFI1", "WBGene00007176", "O17697", "WBGene00008265" ] }, "reaction_10513650": { "compartment": "compartment_876", "id": "reaction_10513650", "reactome": "R-CEL-196017", "name": "Dynamin is recruited to the gap junction plaque", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10512940", "species_10512931" ], "products": [ "species_10512942" ], "modifiers": [], "additional_components": [ "A0A486WXX8", "WBGene00000894", "P35603", "WBGene00001082", "A0A486WXX8", "WBGene00000894", "P35603", "WBGene00001082" ] }, "reaction_10513652": { "compartment": "compartment_876", "id": "reaction_10513652", "reactome": "R-CEL-196026", "name": "Dab2 is recruited to the junctional plaques", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10512924", "species_10512929" ], "products": [ "species_10512931" ], "modifiers": [], "additional_components": [ "P35603", "WBGene00001082", "WBGene00000894", "A0A486WXX8", "WBGene00000894", "P35603", "WBGene00001082" ] }, "reaction_10524969": { "compartment": "compartment_876", "id": "reaction_10524969", "reactome": "R-CEL-445714", "name": "Aquaporin-3 passively transports water out of cell", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356" ], "products": [ "species_109276" ], "modifiers": [ [ "species_10524966", "catalyst" ] ], "additional_components": [ "Q7Z138", "WBGene00000176", "Q9XW36", "WBGene00000171", "Q17571", "WBGene00000170", "Q19949", "WBGene00000169", "Q21473", "WBGene00000175", "Q7YWQ1", "WBGene00013272" ] }, "reaction_10527170": { "compartment": "compartment_876", "id": "reaction_10527170", "reactome": "R-CEL-507869", "name": "Aquaporins passively transport glycerol into cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_192438" ], "products": [ "species_76116" ], "modifiers": [ [ "species_10527167", "catalyst" ] ], "additional_components": [ "Q7YWQ1", "WBGene00013272", "Q17571", "WBGene00000170", "Q7Z138", "WBGene00000176", "Q19949", "WBGene00000169", "Q9XW36", "WBGene00000171", "Q21473", "WBGene00000175" ] }, "reaction_10527172": { "compartment": "compartment_876", "id": "reaction_10527172", "reactome": "R-CEL-507870", "name": "Aquaporins passively transport water out of cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356" ], "products": [ "species_109276" ], "modifiers": [ [ "species_10527162", "catalyst" ] ], "additional_components": [ "Q7YWQ1", "WBGene00013272", "Q17571", "WBGene00000170", "Q7Z138", "WBGene00000176", "Q19949", "WBGene00000169", "Q9XW36", "WBGene00000171", "Q21473", "WBGene00000175", "G5EEK0", "WBGene00000172" ] }, "reaction_10527174": { "compartment": "compartment_876", "id": "reaction_10527174", "reactome": "R-CEL-507871", "name": "Aquaporins passively transport glycerol out of cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76116" ], "products": [ "species_192438" ], "modifiers": [ [ "species_10527167", "catalyst" ] ], "additional_components": [ "Q7YWQ1", "WBGene00013272", "Q17571", "WBGene00000170", "Q7Z138", "WBGene00000176", "Q19949", "WBGene00000169", "Q9XW36", "WBGene00000171", "Q21473", "WBGene00000175" ] }, "reaction_10527179": { "compartment": "compartment_876", "id": "reaction_10527179", "reactome": "R-CEL-507873", "name": "Aquaporins passively transport urea out of cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29514" ], "products": [ "species_432019" ], "modifiers": [ [ "species_10527176", "catalyst" ] ], "additional_components": [ "Q7YWQ1", "WBGene00013272", "Q17571", "WBGene00000170", "Q7Z138", "WBGene00000176", "Q19949", "WBGene00000169", "Q9XW36", "WBGene00000171", "Q21473", "WBGene00000175" ] }, "reaction_10527165": { "compartment": "compartment_876", "id": "reaction_10527165", "reactome": "R-CEL-507868", "name": "Aquaporins passively transport water into cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276" ], "products": [ "species_29356" ], "modifiers": [ [ "species_10527162", "catalyst" ] ], "additional_components": [ "Q7YWQ1", "WBGene00013272", "Q17571", "WBGene00000170", "Q7Z138", "WBGene00000176", "Q19949", "WBGene00000169", "Q9XW36", "WBGene00000171", "Q21473", "WBGene00000175", "G5EEK0", "WBGene00000172" ] }, "reaction_10527181": { "compartment": "compartment_876", "id": "reaction_10527181", "reactome": "R-CEL-507875", "name": "Aquaporins passively transport urea into cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_432019" ], "products": [ "species_29514" ], "modifiers": [ [ "species_10527176", "catalyst" ] ], "additional_components": [ "Q7YWQ1", "WBGene00013272", "Q17571", "WBGene00000170", "Q7Z138", "WBGene00000176", "Q19949", "WBGene00000169", "Q9XW36", "WBGene00000171", "Q21473", "WBGene00000175" ] }, "reaction_10551505": { "compartment": "compartment_70101", "id": "reaction_10551505", "reactome": "R-CEL-5340214", "name": "CYGB binds O2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10551501", "species_29368" ], "products": [ "species_10551503" ], "modifiers": [], "additional_components": [ "species_71185", "O17824", "WBGene00008996", "species_113534", "species_71185", "O17824", "WBGene00008996" ] }, "reaction_10570320": { "compartment": "compartment_70101", "id": "reaction_10570320", "reactome": "R-CEL-8981621", "name": "Neuroglobin:oxygen dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10570316" ], "products": [ "species_10570314", "species_29368" ], "modifiers": [], "additional_components": [ "species_113534", "species_71185", "Q7YZV1", "WBGene00016024", "species_71185", "Q7YZV1", "WBGene00016024" ] }, "reaction_10570501": { "compartment": "compartment_70101", "id": "reaction_10570501", "reactome": "R-CEL-8982617", "name": "CYGB:O2 dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10551503" ], "products": [ "species_10551501", "species_29368" ], "modifiers": [], "additional_components": [ "species_113534", "species_71185", "O17824", "WBGene00008996", "species_71185", "O17824", "WBGene00008996" ] }, "reaction_10570318": { "compartment": "compartment_70101", "id": "reaction_10570318", "reactome": "R-CEL-8981610", "name": "Neuroglobin binds oxygen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10570314", "species_29368" ], "products": [ "species_10570316" ], "modifiers": [], "additional_components": [ "species_71185", "Q7YZV1", "WBGene00016024", "species_113534", "species_71185", "Q7YZV1", "WBGene00016024" ] }, "reaction_10522434": { "compartment": "compartment_876", "id": "reaction_10522434", "reactome": "R-CEL-425483", "name": "SLC4A5,7,9 cotransport Na+ with 3HCO3-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111627", "species_83910" ], "products": [ "species_425425", "species_74113" ], "modifiers": [ [ "species_10522431", "catalyst" ] ], "additional_components": [ "B3WFV9", "WBGene00009920", "Q58QG8", "WBGene00019844" ] }, "reaction_10567850": { "compartment": "compartment_876", "id": "reaction_10567850", "reactome": "R-CEL-8878664", "name": "SLC4A4 cotransports Na+ with 3HCO3-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111627", "species_83910" ], "products": [ "species_425425", "species_74113" ], "modifiers": [ [ "species_10567847", "catalyst" ] ], "additional_components": [ "B3WFV9", "WBGene00009920", "Q58QG8", "WBGene00019844" ] }, "reaction_10522447": { "compartment": "compartment_876", "id": "reaction_10522447", "reactome": "R-CEL-425577", "name": "Na+-driven Cl-/HCO3- exchanger transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_425425", "species_352022", "species_74113" ], "products": [ "species_351626", "species_188972", "species_111627", "species_83910" ], "modifiers": [ [ "species_10522444", "catalyst" ] ], "additional_components": [ "B3WFV9", "WBGene00009920", "Q58QG8", "WBGene00019844" ] }, "reaction_10555169": { "compartment": "compartment_7660", "id": "reaction_10555169", "reactome": "R-CEL-5674387", "name": "Phosphorylated MAPKs translocate into the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10555165" ], "products": [ "species_10555167" ], "modifiers": [], "additional_components": [ "P39745", "WBGene00003401", "P39745", "WBGene00003401" ] }, "reaction_10555224": { "compartment": "compartment_70101", "id": "reaction_10555224", "reactome": "R-CEL-5675376", "name": "Cytosolic DUSPs dephosphorylate MAPKs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10555165", "species_29356" ], "products": [ "species_29372", "species_10555201" ], "modifiers": [ [ "species_10555221", "catalyst" ] ], "additional_components": [ "P39745", "WBGene00003401", "P39745", "WBGene00003401", "Q9XUJ0", "WBGene00012372" ] }, "reaction_10508594": { "compartment": "compartment_70101", "id": "reaction_10508594", "reactome": "R-CEL-109860", "name": "MAP2K1 phosphorylates MAPK3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10508567" ], "products": [ "species_29370", "species_10508585" ], "modifiers": [ [ "species_10508567", "catalyst" ], [ "species_10508590", "inhibitor" ] ], "additional_components": [ "Q10664", "WBGene00003186", "P39745", "WBGene00003401", "Q10664", "WBGene00003186", "P39745", "WBGene00003401", "Q10664", "WBGene00003186", "P39745", "WBGene00003401", "WBGene00003186" ] }, "reaction_10508569": { "compartment": "compartment_70101", "id": "reaction_10508569", "reactome": "R-CEL-109857", "name": "MAP2K1 binds MAPK3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508565", "species_10508560" ], "products": [ "species_10508567" ], "modifiers": [], "additional_components": [ "WBGene00003401", "WBGene00003186", "Q10664", "WBGene00003186", "P39745", "WBGene00003401" ] }, "reaction_10509182": { "compartment": "compartment_70101", "id": "reaction_10509182", "reactome": "R-CEL-112342", "name": "Inactivation of MAP2K1 by CDK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10509173" ], "products": [ "species_10508590", "species_29370" ], "modifiers": [ [ "species_10509179", "catalyst" ] ], "additional_components": [ "Q10664", "WBGene00003186", "WBGene00003186", "WBGene00000405" ] }, "reaction_10508606": { "compartment": "compartment_70101", "id": "reaction_10508606", "reactome": "R-CEL-109863", "name": "Dissociation of p-T,Y-MAPK3:MAP2K1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508585" ], "products": [ "species_10508583", "species_10508560" ], "modifiers": [], "additional_components": [ "Q10664", "WBGene00003186", "P39745", "WBGene00003401", "WBGene00003401", "WBGene00003186" ] }, "reaction_10570242": { "compartment": "compartment_7660", "id": "reaction_10570242", "reactome": "R-CEL-8979071", "name": "KDM6B binds iron", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546680", "species_111793" ], "products": [ "species_10546682" ], "modifiers": [], "additional_components": [ "Q19760", "WBGene00009089", "Q95QK3", "WBGene00017571", "species_113531", "Q19760", "WBGene00009089", "Q95QK3", "WBGene00017571" ] }, "reaction_10546756": { "compartment": "compartment_7660", "id": "reaction_10546756", "reactome": "R-CEL-3240295", "name": "PRC2-EZH2 trimethylates nucleosomes associated with CDKN2A promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10546668" ], "products": [ "species_77502", "species_10546666" ], "modifiers": [ [ "species_10517100", "catalyst" ] ], "additional_components": [ "P62784", "WBGene00001875", "K7ZUH9", "WBGene00001914", "Q10453", "WBGene00001945", "P62784", "WBGene00001875", "Q10453", "WBGene00001945", "K7ZUH9", "WBGene00001914", "Q9GYS1", "WBGene00003224", "O17514", "WBGene00003220", "P90916", "WBGene00003036", "P90917", "WBGene00004312" ] }, "reaction_10546703": { "compartment": "compartment_70101", "id": "reaction_10546703", "reactome": "R-CEL-3225851", "name": "ROS oxidize thioredoxin and activate MAP3K5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546692", "species_1250243" ], "products": [ "species_10506158", "species_10546690" ], "modifiers": [ [ "species_10546697", "catalyst" ] ], "additional_components": [ "Q09433", "WBGene00015062", "Q21029", "WBGene00003822", "WBGene00015062", "WBGene00003822", "WBGene00003247" ] }, "reaction_10546707": { "compartment": "compartment_70101", "id": "reaction_10546707", "reactome": "R-CEL-3228469", "name": "MAP3K5 phosphorylates MKK3 and MKK6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10525576" ], "products": [ "species_29370", "species_10525521" ], "modifiers": [ [ "species_10546690", "catalyst" ] ], "additional_components": [ "Q58AU7", "WBGene00018034", "Q58AU8", "WBGene00018035", "G5EDF7", "WBGene00004758", "Q58AU7", "WBGene00018034", "Q58AU8", "WBGene00018035", "G5EDF7", "WBGene00004758", "WBGene00003822" ] }, "reaction_10546685": { "compartment": "compartment_7660", "id": "reaction_10546685", "reactome": "R-CEL-3222593", "name": "KDM6B demethylates H3K27me3 on p16INK4A promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546666", "species_113671" ], "products": [ "species_10546668", "species_159939" ], "modifiers": [ [ "species_10546682", "catalyst" ] ], "additional_components": [ "P62784", "WBGene00001875", "Q10453", "WBGene00001945", "K7ZUH9", "WBGene00001914", "P62784", "WBGene00001875", "K7ZUH9", "WBGene00001914", "Q10453", "WBGene00001945", "species_113531", "Q19760", "WBGene00009089", "Q95QK3", "WBGene00017571" ] }, "reaction_10524560": { "compartment": "compartment_70101", "id": "reaction_10524560", "reactome": "R-CEL-443831", "name": "14-3-3-zeta binds Raf1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10521086", "species_10507059" ], "products": [ "species_10524558" ], "modifiers": [], "additional_components": [ "WBGene00003030", "Q20655", "WBGene00001502", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "P41932", "WBGene00003920", "Q07292", "WBGene00003030" ] }, "reaction_10524541": { "compartment": "compartment_70101", "id": "reaction_10524541", "reactome": "R-CEL-443439", "name": "c-Src binds Raf1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10521086", "species_10518252" ], "products": [ "species_10524539" ], "modifiers": [], "additional_components": [ "WBGene00003030", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q07292", "WBGene00003030" ] }, "reaction_10516411": { "compartment": "compartment_70101", "id": "reaction_10516411", "reactome": "R-CEL-209828", "name": "Tryptophan is hydroxylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29870", "species_29500", "species_29368" ], "products": [ "species_71112", "species_209911" ], "modifiers": [ [ "species_10516408", "catalyst" ] ], "additional_components": [ "G5EED8", "WBGene00006600", "species_113531" ] }, "reaction_10516429": { "compartment": "compartment_70101", "id": "reaction_10516429", "reactome": "R-CEL-209859", "name": "Decarboxylation of 5-hydroxytryptophan forms serotonin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_209911" ], "products": [ "species_113528", "species_209914" ], "modifiers": [ [ "species_10516426", "catalyst" ] ], "additional_components": [ "O45137", "WBGene00000239" ] }, "reaction_10533009": { "compartment": "compartment_7660", "id": "reaction_10533009", "reactome": "R-CEL-1362270", "name": "Phosphorylation of LIN52 component of MuvB by DYRK1A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10533001" ], "products": [ "species_113582", "species_10532993" ], "modifiers": [ [ "species_10533006", "catalyst" ] ], "additional_components": [ "P90916", "WBGene00003036", "Q95QD7", "WBGene00003037", "Q10120", "WBGene00003035", "P30630", "WBGene00002998", "Q23482", "WBGene00003022", "P90916", "WBGene00003036", "Q95QD7", "WBGene00003037", "P30630", "WBGene00002998", "Q23482", "WBGene00003022", "Q10120", "WBGene00003035", "WBGene00003149" ] }, "reaction_10533091": { "compartment": "compartment_7660", "id": "reaction_10533091", "reactome": "R-CEL-1363314", "name": "p107 (RBL1) binds CyclinE/A:CDK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10532106", "species_10533075" ], "products": [ "species_10533089" ], "modifiers": [], "additional_components": [ "WBGene00003020", "O61847", "WBGene00019362", "O61847", "WBGene00019362", "G5EDT1", "WBGene00003020" ] }, "reaction_10532997": { "compartment": "compartment_7660", "id": "reaction_10532997", "reactome": "R-CEL-1362261", "name": "p130 (RBL2) associates with MuvB to form DREAM complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10532993", "species_10532097" ], "products": [ "species_10532995" ], "modifiers": [], "additional_components": [ "P90916", "WBGene00003036", "Q95QD7", "WBGene00003037", "P30630", "WBGene00002998", "Q23482", "WBGene00003022", "Q10120", "WBGene00003035", "G5EDT1", "WBGene00003020", "G5EF11", "WBGene00001161", "Q22703", "WBGene00001061", "G5EDT1", "WBGene00003020", "G5EF11", "WBGene00001161", "Q22703", "WBGene00001061", "P90916", "WBGene00003036", "Q95QD7", "WBGene00003037", "P30630", "WBGene00002998", "Q23482", "WBGene00003022", "Q10120", "WBGene00003035" ] }, "reaction_10533079": { "compartment": "compartment_7660", "id": "reaction_10533079", "reactome": "R-CEL-1363303", "name": "p130 (RBL2) in complex with E2F4/5:DP1/2 binds to cyclin E/A:CDK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10533075", "species_10532097" ], "products": [ "species_10533077" ], "modifiers": [], "additional_components": [ "O61847", "WBGene00019362", "G5EDT1", "WBGene00003020", "G5EF11", "WBGene00001161", "Q22703", "WBGene00001061", "G5EDT1", "WBGene00003020", "G5EF11", "WBGene00001161", "Q22703", "WBGene00001061", "O61847", "WBGene00019362" ] }, "reaction_10532123": { "compartment": "compartment_7660", "id": "reaction_10532123", "reactome": "R-CEL-1227670", "name": "Recruitment of HDAC1 by p130 (RBL2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10532119", "species_10532097" ], "products": [ "species_10532121" ], "modifiers": [], "additional_components": [ "WBGene00001836", "G5EDT1", "WBGene00003020", "G5EF11", "WBGene00001161", "Q22703", "WBGene00001061", "G5EDT1", "WBGene00003020", "G5EF11", "WBGene00001161", "Q22703", "WBGene00001061", "G5ECH0", "WBGene00001836" ] }, "reaction_10533083": { "compartment": "compartment_7660", "id": "reaction_10533083", "reactome": "R-CEL-1363306", "name": "p130 (RBL2) binds Cyclin E/A:CDK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10533075", "species_10532081" ], "products": [ "species_10533081" ], "modifiers": [], "additional_components": [ "O61847", "WBGene00019362", "WBGene00003020", "G5EDT1", "WBGene00003020", "O61847", "WBGene00019362" ] }, "reaction_10532127": { "compartment": "compartment_7660", "id": "reaction_10532127", "reactome": "R-CEL-1227671", "name": "Recruitment of HDAC1 by p107 (RBL1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10532108", "species_10532119" ], "products": [ "species_10532125" ], "modifiers": [], "additional_components": [ "G5EF11", "WBGene00001161", "G5EDT1", "WBGene00003020", "Q22703", "WBGene00001061", "WBGene00001836", "G5ECH0", "WBGene00001836", "G5EF11", "WBGene00001161", "G5EDT1", "WBGene00003020", "Q22703", "WBGene00001061" ] }, "reaction_10533087": { "compartment": "compartment_7660", "id": "reaction_10533087", "reactome": "R-CEL-1363311", "name": "p107 (RBL1) in complex with E2F4:DP1/2 binds to cyclin E/A:CDK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10532108", "species_10533075" ], "products": [ "species_10533085" ], "modifiers": [], "additional_components": [ "G5EF11", "WBGene00001161", "G5EDT1", "WBGene00003020", "Q22703", "WBGene00001061", "O61847", "WBGene00019362", "O61847", "WBGene00019362", "G5EF11", "WBGene00001161", "G5EDT1", "WBGene00003020", "Q22703", "WBGene00001061" ] }, "reaction_10509407": { "compartment": "compartment_7660", "id": "reaction_10509407", "reactome": "R-CEL-113504", "name": "Detection of damage during initiation of DNA synthesis in S-phase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502577" ], "products": [ "species_10502123", "species_113656" ], "modifiers": [], "additional_components": [ "C7IVS4", "WBGene00012936", "P34471", "WBGene00004180", "O02334", "WBGene00004181", "Q21625", "WBGene00001002", "C7IVS4", "WBGene00012936", "P34471", "WBGene00004180", "O02334", "WBGene00004181", "Q21625", "WBGene00001002" ] }, "reaction_10502244": { "compartment": "compartment_7660", "id": "reaction_10502244", "reactome": "R-CEL-68919", "name": "Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502184", "species_10502240" ], "products": [ "species_10502242" ], "modifiers": [], "additional_components": [ "WBGene00012935", "O16297", "WBGene00003159", "Q95XQ8", "WBGene00003156", "Q9XXI9", "WBGene00003154", "Q21902", "WBGene00003157", "P34647", "WBGene00003158", "Q9XVR7", "WBGene00003155", "Q9XX16", "WBGene00012651", "Q23249", "WBGene00013857", "Q9XX17", "WBGene00012650", "Q21037", "WBGene00003882", "P91155", "WBGene00000382", "Q86S68", "WBGene00000413", "O16297", "WBGene00003159", "Q95XQ8", "WBGene00003156", "Q9XXI9", "WBGene00003154", "Q21902", "WBGene00003157", "P34647", "WBGene00003158", "Q9XVR7", "WBGene00003155", "Q9XX16", "WBGene00012651", "Q23249", "WBGene00013857", "Q9XX17", "WBGene00012650", "Q21037", "WBGene00003882", "P91155", "WBGene00000382", "Q86S68", "WBGene00000413", "Q9U2C2", "WBGene00012935" ] }, "reaction_10502246": { "compartment": "compartment_7660", "id": "reaction_10502246", "reactome": "R-CEL-68940", "name": "Cdt1 is displaced from the pre-replicative complex.", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502242" ], "products": [ "species_10502230", "species_10502099" ], "modifiers": [], "additional_components": [ "O16297", "WBGene00003159", "Q95XQ8", "WBGene00003156", "Q9XXI9", "WBGene00003154", "Q21902", "WBGene00003157", "P34647", "WBGene00003158", "Q9XVR7", "WBGene00003155", "Q9XX16", "WBGene00012651", "Q23249", "WBGene00013857", "Q9XX17", "WBGene00012650", "Q21037", "WBGene00003882", "P91155", "WBGene00000382", "Q86S68", "WBGene00000413", "Q9U2C2", "WBGene00012935", "Q9XX16", "WBGene00012651", "Q23249", "WBGene00013857", "Q9XX17", "WBGene00012650", "Q21037", "WBGene00003882", "P91155", "WBGene00000382", "O16297", "WBGene00003159", "Q95XQ8", "WBGene00003156", "Q9XXI9", "WBGene00003154", "Q21902", "WBGene00003157", "P34647", "WBGene00003158", "Q9XVR7", "WBGene00003155", "Q9U2C2", "WBGene00012935", "WBGene00000413" ] }, "reaction_10502584": { "compartment": "compartment_7660", "id": "reaction_10502584", "reactome": "R-CEL-68960", "name": "DNA polymerase epsilon binds at the origin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_68419", "species_10502145" ], "products": [ "species_10502147" ], "modifiers": [], "additional_components": [ "O62218", "WBGene00009368", "Q19196", "WBGene00017237", "Q22798", "WBGene00020823", "Q9NAC5", "WBGene00013150", "O62218", "WBGene00009368", "Q19196", "WBGene00017237", "Q22798", "WBGene00020823", "Q9NAC5", "WBGene00013150" ] }, "reaction_10502236": { "compartment": "compartment_7660", "id": "reaction_10502236", "reactome": "R-CEL-68917", "name": "Cdc45 associates with the pre-replicative complex at the origin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502232", "species_10502161" ], "products": [ "species_10502234" ], "modifiers": [], "additional_components": [ "O01493", "WBGene00016421", "Q9XX16", "WBGene00012651", "Q23249", "WBGene00013857", "Q9XX17", "WBGene00012650", "Q21037", "WBGene00003882", "P91155", "WBGene00000382", "O16297", "WBGene00003159", "Q95XQ8", "WBGene00003156", "Q9XXI9", "WBGene00003154", "Q21902", "WBGene00003157", "P34647", "WBGene00003158", "Q9XVR7", "WBGene00003155", "Q9U2C2", "WBGene00012935", "O61847", "WBGene00019362", "WBGene00009372", "Q7JMR0", "WBGene00009372", "O01493", "WBGene00016421", "Q9XX16", "WBGene00012651", "Q23249", "WBGene00013857", "Q9XX17", "WBGene00012650", "Q21037", "WBGene00003882", "P91155", "WBGene00000382", "O16297", "WBGene00003159", "Q95XQ8", "WBGene00003156", "Q9XXI9", "WBGene00003154", "Q21902", "WBGene00003157", "P34647", "WBGene00003158", "Q9XVR7", "WBGene00003155", "Q9U2C2", "WBGene00012935", "O61847", "WBGene00019362" ] }, "reaction_10502156": { "compartment": "compartment_7660", "id": "reaction_10502156", "reactome": "R-CEL-68914", "name": "DNA polymerase alpha:primase binds at the origin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502123", "species_10502147" ], "products": [ "species_10502149" ], "modifiers": [], "additional_components": [ "C7IVS4", "WBGene00012936", "P34471", "WBGene00004180", "O02334", "WBGene00004181", "Q21625", "WBGene00001002", "O62218", "WBGene00009368", "Q19196", "WBGene00017237", "Q22798", "WBGene00020823", "Q9NAC5", "WBGene00013150", "O62218", "WBGene00009368", "Q19196", "WBGene00017237", "Q22798", "WBGene00020823", "Q9NAC5", "WBGene00013150", "C7IVS4", "WBGene00012936", "P34471", "WBGene00004180", "O02334", "WBGene00004181", "Q21625", "WBGene00001002" ] }, "reaction_10546046": { "compartment": "compartment_7660", "id": "reaction_10546046", "reactome": "R-CEL-2990840", "name": "SENP1,2,5 proteolytically process SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546014" ], "products": [ "species_10528096" ], "modifiers": [ [ "species_10546043", "catalyst" ] ], "additional_components": [ "WBGene00004888", "WBGene00004888", "O44984", "WBGene00006740", "Q09353", "WBGene00006736", "Q23238", "WBGene00006737" ] }, "reaction_10570130": { "compartment": "compartment_7660", "id": "reaction_10570130", "reactome": "R-CEL-8956365", "name": "ZBED1 (DREF) SUMOylates CHD3 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546081", "species_10548000" ], "products": [ "species_10570122", "species_10546073" ], "modifiers": [ [ "species_10570127", "catalyst" ] ], "additional_components": [ "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "G5EBZ4", "WBGene00002637", "Q22516", "WBGene00000482", "P55853", "WBGene00004888", "G5EBZ4", "WBGene00002637", "Q22516", "WBGene00000482", "WBGene00006706", "WBGene00010704" ] }, "reaction_10549430": { "compartment": "compartment_7660", "id": "reaction_10549430", "reactome": "R-CEL-4616015", "name": "SUMOylation of HDAC2 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10547980", "species_10546081" ], "products": [ "species_10546073", "species_10549428" ], "modifiers": [ [ "species_10546081", "catalyst" ] ], "additional_components": [ "G5ECH0", "WBGene00001836", "Q09440", "WBGene00001835", "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "WBGene00006706", "Q09440", "WBGene00001835", "G5ECH0", "WBGene00001836", "P55853", "WBGene00004888", "Q95017", "WBGene00006706", "P55853", "WBGene00004888" ] }, "reaction_10549306": { "compartment": "compartment_7660", "id": "reaction_10549306", "reactome": "R-CEL-4570496", "name": "SUMOylation of Histone H4 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546081", "species_10506929" ], "products": [ "species_10546073", "species_10549304" ], "modifiers": [ [ "species_10546081", "catalyst" ] ], "additional_components": [ "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "WBGene00001875", "WBGene00006706", "P55853", "WBGene00004888", "P62784", "WBGene00001875", "Q95017", "WBGene00006706", "P55853", "WBGene00004888" ] }, "reaction_10549403": { "compartment": "compartment_7660", "id": "reaction_10549403", "reactome": "R-CEL-4615905", "name": "PIAS1 SUMOylates SATB1 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546081", "species_10518112" ], "products": [ "species_10546073", "species_10549401" ], "modifiers": [ [ "species_10528091", "catalyst" ] ], "additional_components": [ "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "WBGene00022861", "WBGene00006706", "P55853", "WBGene00004888", "Q86MI0", "WBGene00022861", "Q21970", "WBGene00011259", "Q94361", "WBGene00001574" ] }, "reaction_10549391": { "compartment": "compartment_7660", "id": "reaction_10549391", "reactome": "R-CEL-4615889", "name": "SUMOylation of HDAC1 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10532119", "species_10546081" ], "products": [ "species_10549389", "species_10546073" ], "modifiers": [ [ "species_10546081", "catalyst" ] ], "additional_components": [ "WBGene00001836", "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "P55853", "WBGene00004888", "G5ECH0", "WBGene00001836", "WBGene00006706", "Q95017", "WBGene00006706", "P55853", "WBGene00004888" ] }, "reaction_10508432": { "compartment": "compartment_70101", "id": "reaction_10508432", "reactome": "R-CEL-109539", "name": "Concentrative transport (import) of nucleosides plus sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179740", "species_74113" ], "products": [ "species_179741", "species_83910" ], "modifiers": [ [ "species_10508429", "catalyst" ] ], "additional_components": [ "species_83927", "CHEBI:16750", "CHEBI:16704", "species_83909", "species_83909", "species_83927", "CHEBI:16750", "CHEBI:16704", "WBGene00017867" ] }, "reaction_10508417": { "compartment": "compartment_70101", "id": "reaction_10508417", "reactome": "R-CEL-109530", "name": "Concentrative transport (import) of a nucleoside and a sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179738", "species_74113" ], "products": [ "species_179739", "species_83910" ], "modifiers": [ [ "species_10508414", "catalyst" ] ], "additional_components": [ "CHEBI:16704", "species_83928", "species_83909", "CHEBI:17562", "CHEBI:17256", "CHEBI:17256", "species_83909", "CHEBI:16704", "species_83928", "CHEBI:17562", "WBGene00017867" ] }, "reaction_10508420": { "compartment": "compartment_70101", "id": "reaction_10508420", "reactome": "R-CEL-109534", "name": "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179743" ], "products": [ "species_179737" ], "modifiers": [ [ "species_10508404", "catalyst" ] ], "additional_components": [ "species_83909", "species_83927", "CHEBI:16750", "CHEBI:16704", "species_83928", "CHEBI:17562", "species_83927", "CHEBI:16750", "CHEBI:16704", "species_83928", "species_83909", "CHEBI:17562", "WBGene00009499" ] }, "reaction_10527797": { "compartment": "compartment_70101", "id": "reaction_10527797", "reactome": "R-CEL-727749", "name": "SLC29A3 transports nucleosides from lysosomal lumen to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_727782" ], "products": [ "species_727746" ], "modifiers": [ [ "species_10527794", "catalyst" ] ], "additional_components": [ "species_83909", "species_83927", "CHEBI:16704", "CHEBI:16750", "CHEBI:17562", "species_83928", "species_83951", "species_83909", "species_83927", "CHEBI:16750", "CHEBI:16704", "species_83928", "CHEBI:17562", "species_83951", "WBGene00009499" ] }, "reaction_10508422": { "compartment": "compartment_70101", "id": "reaction_10508422", "reactome": "R-CEL-109536", "name": "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179737" ], "products": [ "species_179743" ], "modifiers": [ [ "species_10508404", "catalyst" ] ], "additional_components": [ "species_83927", "CHEBI:16750", "CHEBI:16704", "species_83928", "species_83909", "CHEBI:17562", "species_83909", "species_83927", "CHEBI:16750", "CHEBI:16704", "species_83928", "CHEBI:17562", "WBGene00009499" ] }, "reaction_10508407": { "compartment": "compartment_70101", "id": "reaction_10508407", "reactome": "R-CEL-109527", "name": "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179747" ], "products": [ "species_179742" ], "modifiers": [ [ "species_10508402", "catalyst" ] ], "additional_components": [ "species_83927", "CHEBI:16750", "species_83956", "CHEBI:16704", "species_83928", "species_113599", "species_83909", "species_83960", "species_83962", "species_83951", "CHEBI:17562", "CHEBI:16040", "species_83909", "CHEBI:16040", "species_83956", "species_83927", "CHEBI:16750", "CHEBI:16704", "species_83928", "species_83960", "species_83962", "CHEBI:17562", "species_83951", "species_113599", "WBGene00009499" ] }, "reaction_10508409": { "compartment": "compartment_70101", "id": "reaction_10508409", "reactome": "R-CEL-109529", "name": "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179742" ], "products": [ "species_179747" ], "modifiers": [ [ "species_10508402", "catalyst" ] ], "additional_components": [ "species_83909", "CHEBI:16040", "species_83956", "species_83927", "CHEBI:16750", "CHEBI:16704", "species_83928", "species_83960", "species_83962", "CHEBI:17562", "species_83951", "species_113599", "species_83927", "CHEBI:16750", "species_83956", "CHEBI:16704", "species_83928", "species_113599", "species_83909", "species_83960", "species_83962", "species_83951", "CHEBI:17562", "CHEBI:16040", "WBGene00009499" ] }, "reaction_10510169": { "compartment": "compartment_70616", "id": "reaction_10510169", "reactome": "R-CEL-163215", "name": "SLC25A5,6 dimers exchange ATP for ADP across the mitochondrial inner membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29370", "species_113593" ], "products": [ "species_113581", "species_113592" ], "modifiers": [ [ "species_10510166", "catalyst" ] ], "additional_components": [ "P91270", "WBGene00017770" ] }, "reaction_10508427": { "compartment": "compartment_70101", "id": "reaction_10508427", "reactome": "R-CEL-109538", "name": "Concentrative transport (import) of a nucleoside and two sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179737", "species_74113" ], "products": [ "species_179743", "species_83910" ], "modifiers": [ [ "species_10508424", "catalyst" ] ], "additional_components": [ "species_83927", "CHEBI:16750", "CHEBI:16704", "species_83928", "species_83909", "CHEBI:17562", "species_83909", "species_83927", "CHEBI:16750", "CHEBI:16704", "species_83928", "CHEBI:17562", "WBGene00017867" ] }, "reaction_10528229": { "compartment": "compartment_876", "id": "reaction_10528229", "reactome": "R-CEL-879585", "name": "SLC27A1,4,6 transport LCFAs from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_879559" ], "products": [ "species_879544" ], "modifiers": [ [ "species_10528226", "catalyst" ] ], "additional_components": [ "CHEBI:16196", "CHEBI:16196", "Q18916", "WBGene00017012", "Q19878", "WBGene00009218" ] }, "reaction_10527805": { "compartment": "compartment_20699", "id": "reaction_10527805", "reactome": "R-CEL-727759", "name": "SLC33A1 transports Ac-CoA from cytosol to Golgi lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76183" ], "products": [ "species_727753" ], "modifiers": [ [ "species_10527802", "catalyst" ] ], "additional_components": [ "WBGene00012033" ] }, "reaction_10528210": { "compartment": "compartment_876", "id": "reaction_10528210", "reactome": "R-CEL-879575", "name": "SLCOs, SLC16A2 transport T3,T4 from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_879603" ], "products": [ "species_879628" ], "modifiers": [ [ "species_10528207", "catalyst" ] ], "additional_components": [ "species_352326", "species_176667", "species_352326", "species_176667", "Q95ZT3", "WBGene00018568", "O62421", "WBGene00018568", "Q20538", "WBGene00018568", "Q93550", "WBGene00018568", "Q9XWC5", "WBGene00019346", "X5LPS1", "WBGene00019346", "X5LV99", "WBGene00019346" ] }, "reaction_10528168": { "compartment": "compartment_876", "id": "reaction_10528168", "reactome": "R-CEL-879562", "name": "SLCO2B1 has a narrow substrate specificity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_879553" ], "products": [ "species_879654" ], "modifiers": [ [ "species_10528165", "catalyst" ] ], "additional_components": [ "species_176496", "CHEBI:63836", "species_176501", "CHEBI:63836", "species_176501", "species_176496", "Q93550", "WBGene00018568", "Q95ZT3", "WBGene00018568", "O62421", "WBGene00018568", "Q20538", "WBGene00018568" ] }, "reaction_10572296": { "compartment": "compartment_876", "id": "reaction_10572296", "reactome": "R-CEL-9631987", "name": "SLCO1B1 transports T3,T4 from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_879603" ], "products": [ "species_879628" ], "modifiers": [ [ "species_10528178", "catalyst" ] ], "additional_components": [ "species_352326", "species_176667", "species_352326", "species_176667", "Q95ZT3", "WBGene00018568", "O62421", "WBGene00018568", "Q20538", "WBGene00018568", "Q93550", "WBGene00018568" ] }, "reaction_10528234": { "compartment": "compartment_876", "id": "reaction_10528234", "reactome": "R-CEL-879594", "name": "SLCO4C1 mediates the transport of digoxin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_879521" ], "products": [ "species_879517" ], "modifiers": [ [ "species_10528231", "catalyst" ] ], "additional_components": [ "WBGene00019346" ] }, "reaction_10528155": { "compartment": "compartment_876", "id": "reaction_10528155", "reactome": "R-CEL-879528", "name": "SLCO2A1 transports PGT substrates from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_879566" ], "products": [ "species_879614" ], "modifiers": [ [ "species_10528152", "catalyst" ] ], "additional_components": [ "species_879535", "CHEBI:15544", "species_879629", "species_265287", "species_879629", "CHEBI:15544", "species_879535", "species_265287", "Q93550", "WBGene00018568", "Q95ZT3", "WBGene00018568", "O62421", "WBGene00018568", "Q20538", "WBGene00018568" ] }, "reaction_10543903": { "compartment": "compartment_876", "id": "reaction_10543903", "reactome": "R-CEL-2317314", "name": "AKT binds PDPK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10513830", "species_10508530" ], "products": [ "species_10513832" ], "modifiers": [], "additional_components": [ "Q17941", "WBGene00000102", "Q9XTG7", "WBGene00000103", "G4S4W1", "WBGene00016980", "species_179838", "Q9UA62", "WBGene00021022", "species_179838", "Q9UA62", "WBGene00021022", "species_179838", "Q17941", "WBGene00000102", "Q9XTG7", "WBGene00000103", "G4S4W1", "WBGene00016980" ] }, "reaction_10543806": { "compartment": "compartment_70101", "id": "reaction_10543806", "reactome": "R-CEL-2316429", "name": "PIP3 recruits PDPK1 to the membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179838", "species_10515193" ], "products": [ "species_10508530" ], "modifiers": [], "additional_components": [ "WBGene00021022", "Q9UA62", "WBGene00021022", "species_179838" ] }, "reaction_10543581": { "compartment": "compartment_70101", "id": "reaction_10543581", "reactome": "R-CEL-2219524", "name": "PDPK1 binds PIP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10515193", "species_179856" ], "products": [ "species_10543579" ], "modifiers": [], "additional_components": [ "WBGene00021022", "Q9UA62", "WBGene00021022", "species_179856" ] }, "reaction_10513851": { "compartment": "compartment_70101", "id": "reaction_10513851", "reactome": "R-CEL-198270", "name": "PDPK1 phosphorylates AKT at T308", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10513832" ], "products": [ "species_29370", "species_10513848", "species_10508530" ], "modifiers": [ [ "species_10513832", "catalyst" ] ], "additional_components": [ "Q9UA62", "WBGene00021022", "species_179838", "Q17941", "WBGene00000102", "Q9XTG7", "WBGene00000103", "G4S4W1", "WBGene00016980", "Q9XTG7", "WBGene00000103", "G4S4W1", "WBGene00016980", "Q17941", "WBGene00000102", "Q9UA62", "WBGene00021022", "species_179838", "Q9UA62", "WBGene00021022", "species_179838", "Q17941", "WBGene00000102", "Q9XTG7", "WBGene00000103", "G4S4W1", "WBGene00016980" ] }, "reaction_10513960": { "compartment": "compartment_70101", "id": "reaction_10513960", "reactome": "R-CEL-198640", "name": "TORC2 (mTOR) phosphorylates AKT at S473", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10513939" ], "products": [ "species_29370", "species_10513830" ], "modifiers": [ [ "species_10513953", "catalyst" ], [ "species_10513958", "inhibitor" ] ], "additional_components": [ "Q17941", "WBGene00000102", "Q9XTG7", "WBGene00000103", "G4S4W1", "WBGene00016980", "species_179838", "Q17941", "WBGene00000102", "Q9XTG7", "WBGene00000103", "G4S4W1", "WBGene00016980", "species_179838", "P91040", "WBGene00015697", "Q95Q95", "WBGene00002583", "G5EFN2", "WBGene00009245", "Q9NA80", "WBGene00013261", "Q17941", "WBGene00000102", "Q9XTG7", "WBGene00000103", "G4S4W1", "WBGene00016980", "species_179838", "G5EED4", "WBGene00010700" ] }, "reaction_10509479": { "compartment": "compartment_70101", "id": "reaction_10509479", "reactome": "R-CEL-114542", "name": "RAC1,RAC2,RHOG activate PI3K", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10506892", "species_10509473" ], "products": [ "species_10509477" ], "modifiers": [], "additional_components": [ "G5EDP9", "WBGene00000001", "Q94125", "WBGene00000090", "species_29438", "Q03206", "ced-10", "Q94124", "WBGene00004287", "Q9BL44", "WBGene00022177", "species_29438", "Q03206", "ced-10", "Q94124", "WBGene00004287", "Q9BL44", "WBGene00022177", "G5EDP9", "WBGene00000001", "Q94125", "WBGene00000090" ] }, "reaction_10514322": { "compartment": "compartment_876", "id": "reaction_10514322", "reactome": "R-CEL-199443", "name": "THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10513956", "species_10513939" ], "products": [ "species_10513958" ], "modifiers": [], "additional_components": [ "WBGene00010700", "Q17941", "WBGene00000102", "Q9XTG7", "WBGene00000103", "G4S4W1", "WBGene00016980", "species_179838", "Q17941", "WBGene00000102", "Q9XTG7", "WBGene00000103", "G4S4W1", "WBGene00016980", "species_179838", "G5EED4", "WBGene00010700" ] }, "reaction_10514330": { "compartment": "compartment_70101", "id": "reaction_10514330", "reactome": "R-CEL-199456", "name": "PTEN dephosphorylates PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_179838" ], "products": [ "species_29372", "species_179856" ], "modifiers": [ [ "species_10514327", "catalyst" ] ], "additional_components": [ "WBGene00000913" ] }, "reaction_10543905": { "compartment": "compartment_70101", "id": "reaction_10543905", "reactome": "R-CEL-2317332", "name": "PIP3 recruits AKT to the membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179838", "species_10520802" ], "products": [ "species_10513939" ], "modifiers": [], "additional_components": [ "G4S4W1", "WBGene00016980", "Q17941", "WBGene00000102", "Q9XTG7", "WBGene00000103", "Q17941", "WBGene00000102", "Q9XTG7", "WBGene00000103", "G4S4W1", "WBGene00016980", "species_179838" ] }, "reaction_10565073": { "compartment": "compartment_70101", "id": "reaction_10565073", "reactome": "R-CEL-8850992", "name": "Proteasome degrades polyubiquitinated PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10565071" ], "products": [ "species_10502375" ], "modifiers": [ [ "species_10502572", "catalyst" ] ], "additional_components": [ "G5EE01", "WBGene00000913", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "P91477", "WBGene00003950", "Q95PZ7", "WBGene00013435", "Q18115", "WBGene00004459", "O62102", "WBGene00003948", "O17071", "WBGene00004504", "Q10920", "WBGene00016623", "P34286", "WBGene00003952", "Q9XTT9", "WBGene00004506", "Q23449", "WBGene00004468", "Q95005", "WBGene00003925", "P46502", "WBGene00004503", "O61792", "WBGene00004464", "O17586", "WBGene00003922", "O76371", "WBGene00004505", "Q20585", "WBGene00004463", "Q95008", "WBGene00003926", "Q18787", "WBGene00004501", "Q20058", "WBGene00009445", "Q9N599", "WBGene00003924", "O16368", "WBGene00004502", "O61742", "WBGene00004466", "Q09583", "WBGene00003928", "Q966I8", "WBGene00003947", "Q04908", "WBGene00004460", "Q9XUV0", "WBGene00003951", "Q27488", "WBGene00003923", "Q9GZH5", "WBGene00004458", "O44156", "WBGene00003927", "Q22253", "WBGene00004465", "O76577", "WBGene00004467", "P90868", "WBGene00003953", "Q19324", "WBGene00004461", "Q17971", "WBGene00007588", "Q23237", "WBGene00003949", "Q20938", "WBGene00004462" ] }, "reaction_10564578": { "compartment": "compartment_70101", "id": "reaction_10564578", "reactome": "R-CEL-8847968", "name": "PTEN binds FRK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10564574", "species_10514327" ], "products": [ "species_10564576" ], "modifiers": [], "additional_components": [ "WBGene00005078", "WBGene00000913", "G5EE01", "WBGene00000913", "O45539", "WBGene00005078" ] }, "reaction_10565061": { "compartment": "compartment_70101", "id": "reaction_10565061", "reactome": "R-CEL-8850945", "name": "Casein kinase II phosphorylates PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10514327" ], "products": [ "species_29370", "species_10565059" ], "modifiers": [ [ "species_10515097", "catalyst" ] ], "additional_components": [ "WBGene00000913", "WBGene00000913", "P18334", "WBGene00002191", "P28548", "WBGene00002196" ] }, "reaction_10563159": { "compartment": "compartment_70101", "id": "reaction_10563159", "reactome": "R-CEL-6807134", "name": "NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502375", "species_10514327" ], "products": [ "species_10563152" ], "modifiers": [ [ "species_10563156", "catalyst" ] ], "additional_components": [ "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "WBGene00000913", "WBGene00000913", "G5ECY6", "WBGene00000500", "Q9N2Z7", "WBGene00007009", "A0A061ACQ8", "WBGene00022358" ] }, "reaction_10565079": { "compartment": "compartment_70101", "id": "reaction_10565079", "reactome": "R-CEL-8850997", "name": "TRIM27 binds PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10514327", "species_10565075" ], "products": [ "species_10565077" ], "modifiers": [], "additional_components": [ "WBGene00000913", "WBGene00021640", "Q9N3T6", "WBGene00021640", "G5EE01", "WBGene00000913" ] }, "reaction_10568856": { "compartment": "compartment_70101", "id": "reaction_10568856", "reactome": "R-CEL-8948775", "name": "MKRN1 polyubiquitinates PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502375", "species_10514327" ], "products": [ "species_10563162" ], "modifiers": [ [ "species_10568851", "catalyst" ] ], "additional_components": [ "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "WBGene00000913", "WBGene00000913", "WBGene00002278" ] }, "reaction_10564584": { "compartment": "compartment_70101", "id": "reaction_10564584", "reactome": "R-CEL-8847977", "name": "FRK phosphorylates PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10564576" ], "products": [ "species_10564574", "species_29370", "species_10564581" ], "modifiers": [ [ "species_10564576", "catalyst" ] ], "additional_components": [ "G5EE01", "WBGene00000913", "O45539", "WBGene00005078", "WBGene00005078", "WBGene00000913", "G5EE01", "WBGene00000913", "O45539", "WBGene00005078" ] }, "reaction_10568861": { "compartment": "compartment_70101", "id": "reaction_10568861", "reactome": "R-CEL-8948832", "name": "RNF146 polyubiquitinates PARylated PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10568858", "species_10502375" ], "products": [ "species_10565069" ], "modifiers": [ [ "species_10547738", "catalyst" ] ], "additional_components": [ "WBGene00000913", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "WBGene00000913", "WBGene00013674" ] }, "reaction_10565085": { "compartment": "compartment_70101", "id": "reaction_10565085", "reactome": "R-CEL-8851011", "name": "TRIM27 polyubiquitinates PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502375", "species_10565077" ], "products": [ "species_10565082", "species_10565075" ], "modifiers": [ [ "species_10565077", "catalyst" ] ], "additional_components": [ "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "Q9N3T6", "WBGene00021640", "G5EE01", "WBGene00000913", "WBGene00000913", "WBGene00021640", "Q9N3T6", "WBGene00021640", "G5EE01", "WBGene00000913" ] }, "reaction_10568800": { "compartment": "compartment_13231", "id": "reaction_10568800", "reactome": "R-CEL-8944457", "name": "MAF1 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10568791" ], "products": [ "species_10568789" ], "modifiers": [ [ "species_10510588", "inhibitor" ] ], "additional_components": [ "WBGene00016622", "WBGene00016622", "Q19425", "WBGene00008774", "species_29420", "G5EGB3", "WBGene00012497", "Q22743", "WBGene00006414", "species_29438", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "P91040", "WBGene00015697", "Q95Q95", "WBGene00002583", "Q68TI8", "WBGene00000911", "P34443", "WBGene00010038" ] }, "reaction_10568738": { "compartment": "compartment_7660", "id": "reaction_10568738", "reactome": "R-CEL-8943817", "name": "MECOM (EVI1) recruits polycomb repressor complexes (PRCs) to the PTEN gene promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10568732", "species_10568730" ], "products": [ "species_10568736" ], "modifiers": [], "additional_components": [ "Q22024", "WBGene00001207", "Q22024", "WBGene00001207" ] }, "reaction_10568726": { "compartment": "compartment_7660", "id": "reaction_10568726", "reactome": "R-CEL-8943780", "name": "SALL4 recruits NuRD to PTEN gene", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10548019", "species_10568720" ], "products": [ "species_10568724" ], "modifiers": [], "additional_components": [ "P90916", "WBGene00003036", "G5EBZ4", "WBGene00002637", "Q22516", "WBGene00000482", "G5ECR1", "WBGene00023409", "O61907", "WBGene00003025", "P90917", "WBGene00004312", "G5ECH0", "WBGene00001836", "Q09440", "WBGene00001835", "G5EFF4", "WBGene00004773", "P90916", "WBGene00003036", "G5EBZ4", "WBGene00002637", "Q22516", "WBGene00000482", "G5ECR1", "WBGene00023409", "O61907", "WBGene00003025", "P90917", "WBGene00004312", "G5ECH0", "WBGene00001836", "Q09440", "WBGene00001835", "G5EFF4", "WBGene00004773" ] }, "reaction_10568798": { "compartment": "compartment_70101", "id": "reaction_10568798", "reactome": "R-CEL-8944454", "name": "mTORC1 phosphorylates MAF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10568791" ], "products": [ "species_10568796", "species_29370" ], "modifiers": [ [ "species_10510588", "catalyst" ] ], "additional_components": [ "WBGene00016622", "WBGene00016622", "Q19425", "WBGene00008774", "species_29420", "G5EGB3", "WBGene00012497", "Q22743", "WBGene00006414", "species_29438", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "P91040", "WBGene00015697", "Q95Q95", "WBGene00002583", "Q68TI8", "WBGene00000911", "P34443", "WBGene00010038" ] }, "reaction_10563141": { "compartment": "compartment_70101", "id": "reaction_10563141", "reactome": "R-CEL-6807105", "name": "Monoubiquitinated PTEN translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10563135" ], "products": [ "species_10563139" ], "modifiers": [], "additional_components": [ "WBGene00000913", "WBGene00000913" ] }, "reaction_10563146": { "compartment": "compartment_7660", "id": "reaction_10563146", "reactome": "R-CEL-6807118", "name": "USP7 deubiquitinates monoubiquitinated PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10563139" ], "products": [ "species_10502318", "species_10563143" ], "modifiers": [ [ "species_10556169", "catalyst" ], [ "species_10546215", "inhibitor" ] ], "additional_components": [ "WBGene00000913", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "WBGene00000913", "WBGene00010406", "WBGene00006523" ] }, "reaction_10563149": { "compartment": "compartment_7660", "id": "reaction_10563149", "reactome": "R-CEL-6807126", "name": "Deubiquitinated PTEN translocates to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10563143" ], "products": [ "species_10514327" ], "modifiers": [], "additional_components": [ "WBGene00000913", "WBGene00000913" ] }, "reaction_10503794": { "compartment": "compartment_70101", "id": "reaction_10503794", "reactome": "R-CEL-71164", "name": "homogentisate + O2 => maleylacetoacetate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_30337" ], "products": [ "species_31135" ], "modifiers": [ [ "species_10503791", "catalyst" ] ], "additional_components": [ "species_113531", "Q9Y041", "WBGene00001843" ] }, "reaction_10503765": { "compartment": "compartment_70101", "id": "reaction_10503765", "reactome": "R-CEL-71155", "name": "tyrosine + alpha-ketoglutarate <=> p-hydroxyphenylpyruvate + glutamate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29406", "species_29506" ], "products": [ "species_29404", "species_31365" ], "modifiers": [ [ "species_10503762", "catalyst" ] ], "additional_components": [ "Q93703", "WBGene00009628" ] }, "reaction_10503814": { "compartment": "compartment_70101", "id": "reaction_10503814", "reactome": "R-CEL-71181", "name": "fumarylacetoacetate => fumarate + acetoacetate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_31175" ], "products": [ "species_29666", "species_29586" ], "modifiers": [ [ "species_10503811", "catalyst" ] ], "additional_components": [ "Q94272", "WBGene00019620" ] }, "reaction_10503784": { "compartment": "compartment_70101", "id": "reaction_10503784", "reactome": "R-CEL-71163", "name": "p-hydroxyphenylpyruvate + O2 => homogentisate + CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_31365" ], "products": [ "species_113528", "species_30337" ], "modifiers": [ [ "species_10503781", "catalyst" ] ], "additional_components": [ "Q18347", "WBGene00016294", "Q22633", "WBGene00001993", "species_198836", "species_113531" ] }, "reaction_10503804": { "compartment": "compartment_70101", "id": "reaction_10503804", "reactome": "R-CEL-71173", "name": "maleylacetoacetate => fumarylacetoacetate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_31135" ], "products": [ "species_31175" ], "modifiers": [ [ "species_10503801", "catalyst" ] ], "additional_components": [ "Q18938", "WBGene00001790", "species_1655887" ] }, "reaction_10534912": { "compartment": "compartment_12045", "id": "reaction_10534912", "reactome": "R-CEL-1482867", "name": "DLCL is acylated to MLCL by LCLAT1 (ER)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524080", "species_1500578" ], "products": [ "species_76194", "species_1524069" ], "modifiers": [ [ "species_10507525", "catalyst" ] ], "additional_components": [ "WBGene00020264" ] }, "reaction_10534881": { "compartment": "compartment_70616", "id": "reaction_10534881", "reactome": "R-CEL-1482781", "name": "MLCL and PC are converted to CL and 1-acyl LPC by TAZ (IM) (Reversible)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524075", "species_1498773" ], "products": [ "species_1524072", "species_1524079" ], "modifiers": [ [ "species_10534878", "catalyst" ] ], "additional_components": [ "WBGene00006491" ] }, "reaction_10534899": { "compartment": "compartment_70616", "id": "reaction_10534899", "reactome": "R-CEL-1482850", "name": "MLCL and PE are converted to CL and 1-acyl LPE by TAZ (IM) (Reversible)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524083", "species_1498773" ], "products": [ "species_1524072", "species_1524089" ], "modifiers": [ [ "species_10534878", "catalyst" ] ], "additional_components": [ "WBGene00006491" ] }, "reaction_10534868": { "compartment": "compartment_70616", "id": "reaction_10534868", "reactome": "R-CEL-1482775", "name": "MLCL is acylated to CL by HADH (IM)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1498773", "species_1524038" ], "products": [ "species_1524072", "species_29374" ], "modifiers": [ [ "species_10534865", "catalyst" ] ], "additional_components": [ "P34255", "WBGene00015125", "Q9GYT0", "WBGene00020347" ] }, "reaction_10534910": { "compartment": "compartment_12045", "id": "reaction_10534910", "reactome": "R-CEL-1482861", "name": "MLCL is acylated to CL by LCLAT1 (ER)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500578", "species_1524069" ], "products": [ "species_1524081", "species_76194" ], "modifiers": [ [ "species_10507525", "catalyst" ] ], "additional_components": [ "WBGene00020264" ] }, "reaction_10520252": { "compartment": "compartment_876", "id": "reaction_10520252", "reactome": "R-CEL-381750", "name": "Olfactory Receptor - G Protein olfactory trimer complex formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10520171", "species_10520178" ], "products": [ "species_10520198" ], "modifiers": [ [ "species_10520250", "catalyst" ] ], "additional_components": [ "Q7KPV0", "WBGene00001745", "V6CLB7", "WBGene00020997", "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682", "WBGene00001052", "Q86ME6", "WBGene00001052", "Q7KPV0", "WBGene00001745", "V6CLB7", "WBGene00020997", "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682", "Q10010", "WBGene00020562", "P34296", "WBGene00020562" ] }, "reaction_10520173": { "compartment": "compartment_876", "id": "reaction_10520173", "reactome": "R-CEL-381749", "name": "G Protein trimer formation (olfactory)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509147", "species_10510821", "species_10511281" ], "products": [ "species_10520171" ], "modifiers": [], "additional_components": [ "WBGene00001682", "WBGene00001679", "Q7KPV0", "WBGene00001745", "V6CLB7", "WBGene00020997", "Q7KPV0", "WBGene00001745", "V6CLB7", "WBGene00020997", "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682" ] }, "reaction_10568896": { "compartment": "compartment_70616", "id": "reaction_10568896", "reactome": "R-CEL-8949580", "name": "F1Fo ATP synthase dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10510406" ], "products": [ "species_10568894" ], "modifiers": [], "additional_components": [ "O16314", "WBGene00015460", "Q18803", "WBGene00000210", "Q17763", "WBGene00007385", "Q19126", "WBGene00000207", "Q9BKS0", "WBGene00022336", "Q21732", "WBGene00011015", "O16517", "WBGene00020275", "Q22021", "WBGene00011273", "Q09544", "WBGene00019061", "Q9XXK1", "WBGene00010419", "O16298", "WBGene00017982", "P46561", "WBGene00000229", "Q95XJ0", "WBGene00022089", "Q7JNG1", "WBGene00000230", "O16314", "WBGene00015460", "Q18803", "WBGene00000210", "Q17763", "WBGene00007385", "Q19126", "WBGene00000207", "Q9BKS0", "WBGene00022336", "Q21732", "WBGene00011015", "O16517", "WBGene00020275", "Q22021", "WBGene00011273", "Q09544", "WBGene00019061", "Q9XXK1", "WBGene00010419", "O16298", "WBGene00017982", "P46561", "WBGene00000229", "Q95XJ0", "WBGene00022089", "Q7JNG1", "WBGene00000230" ] }, "reaction_10549204": { "compartment": "compartment_12045", "id": "reaction_10549204", "reactome": "R-CEL-4419979", "name": "SRD5A3 reduces pPNOL to DCHOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_4419981", "species_29364" ], "products": [ "species_29366", "species_449221" ], "modifiers": [ [ "species_10549201", "catalyst" ] ], "additional_components": [ "WBGene00007102" ] }, "reaction_10525099": { "compartment": "compartment_12045", "id": "reaction_10525099", "reactome": "R-CEL-446195", "name": "DOLK phosphorylates DCHOL to DOLP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_110614", "species_449221" ], "products": [ "species_110094", "species_449299" ], "modifiers": [ [ "species_10525096", "catalyst" ] ], "additional_components": [ "WBGene00044233" ] }, "reaction_10549196": { "compartment": "compartment_12045", "id": "reaction_10549196", "reactome": "R-CEL-4419978", "name": "DHDDS:NUS1 elongates E,E-FPP with (n)IPPP to form pPPP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191362", "species_4419987" ], "products": [ "species_4419982" ], "modifiers": [ [ "species_10549193", "catalyst" ] ], "additional_components": [ "Q5FC21", "WBGene00044025", "Q20118", "WBGene00009505" ] }, "reaction_10523190": { "compartment": "compartment_17938", "id": "reaction_10523190", "reactome": "R-CEL-428585", "name": "SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428040", "species_428639" ], "products": [ "species_428633", "species_70106" ], "modifiers": [ [ "species_10523187", "catalyst" ] ], "additional_components": [ "WBGene00008000" ] }, "reaction_10525409": { "compartment": "compartment_70101", "id": "reaction_10525409", "reactome": "R-CEL-449715", "name": "GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29512", "species_29472" ], "products": [ "species_29404", "species_449701" ], "modifiers": [ [ "species_10525406", "catalyst" ] ], "additional_components": [ "Q19130", "WBGene00008546", "Q19699", "WBGene00009035" ] }, "reaction_10525137": { "compartment": "compartment_70101", "id": "reaction_10525137", "reactome": "R-CEL-446204", "name": "GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29494", "species_532204" ], "products": [ "species_111294", "species_162756" ], "modifiers": [ [ "species_10525134", "catalyst" ] ], "additional_components": [ "Q18493", "WBGene00007965" ] }, "reaction_10563013": { "compartment": "compartment_70101", "id": "reaction_10563013", "reactome": "R-CEL-6803771", "name": "NAGK dimer phosphorylates GlcNAc, GlcNGc to GlcNAc-6-P, GlcNGc-6-P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6803785", "species_113592" ], "products": [ "species_6803738", "species_70106", "species_29370" ], "modifiers": [ [ "species_10563010", "catalyst" ] ], "additional_components": [ "CHEBI:27459", "species_1678743", "species_449703", "species_6803743", "Q23196", "WBGene00021056" ] }, "reaction_10525061": { "compartment": "compartment_70101", "id": "reaction_10525061", "reactome": "R-CEL-446185", "name": "Isomerization of GlcNAc6P to GlcNAc1P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449703" ], "products": [ "species_532204" ], "modifiers": [ [ "species_10525058", "catalyst" ] ], "additional_components": [ "WBGene00009006" ] }, "reaction_10525419": { "compartment": "compartment_70101", "id": "reaction_10525419", "reactome": "R-CEL-449734", "name": "Acetylation of glucosamine 6-phosphate to GlcNAc6P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76183", "species_449701" ], "products": [ "species_76194", "species_449703" ], "modifiers": [ [ "species_10525416", "catalyst" ] ], "additional_components": [ "Q17427", "WBGene00001646" ] }, "reaction_10563021": { "compartment": "compartment_70101", "id": "reaction_10563021", "reactome": "R-CEL-6803789", "name": "AMDHD2 hydrolyses GlcNGc-6-P to GlcN6P and CCA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_6803743" ], "products": [ "species_193473", "species_449701" ], "modifiers": [ [ "species_10563018", "catalyst" ] ], "additional_components": [ "WBGene00010308" ] }, "reaction_10527233": { "compartment": "compartment_70101", "id": "reaction_10527233", "reactome": "R-CEL-532549", "name": "MPI isomerises Fru6P to Man6P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29512" ], "products": [ "species_532562" ], "modifiers": [ [ "species_10527230", "catalyst" ] ], "additional_components": [ "WBGene00014013" ] }, "reaction_10525119": { "compartment": "compartment_70101", "id": "reaction_10525119", "reactome": "R-CEL-446201", "name": "PMM1,2 isomerise Man6P to Man1P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_532562" ], "products": [ "species_532531" ], "modifiers": [ [ "species_10525116", "catalyst" ] ], "additional_components": [ "Q9XUE6", "WBGene00009925" ] }, "reaction_10558241": { "compartment": "compartment_70101", "id": "reaction_10558241", "reactome": "R-CEL-6787540", "name": "FUK phosphorylates beta-Fuc to Fuc1P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_6787678" ], "products": [ "species_29370", "species_6787542" ], "modifiers": [ [ "species_10558238", "catalyst" ] ], "additional_components": [ "WBGene00007745" ] }, "reaction_10558259": { "compartment": "compartment_70101", "id": "reaction_10558259", "reactome": "R-CEL-6787632", "name": "GMDS dehydrates GDP-Man to GDP-DHDMan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_162860" ], "products": [ "species_29356", "species_6787618" ], "modifiers": [ [ "species_10558256", "catalyst" ] ], "additional_components": [ "WBGene00000266" ] }, "reaction_10558262": { "compartment": "compartment_70101", "id": "reaction_10558262", "reactome": "R-CEL-6787642", "name": "TSTA3 dimer reduces GDP-KDGal to GDP-Fuc", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_6787646", "species_29364" ], "products": [ "species_742368", "species_29366" ], "modifiers": [ [ "species_10558248", "catalyst" ] ], "additional_components": [ "G5EER4", "WBGene00019813" ] }, "reaction_10558233": { "compartment": "compartment_70101", "id": "reaction_10558233", "reactome": "R-CEL-6787533", "name": "FPGT transfers guanylyl group from GTP to Fuc1P to form GDP-Fuc", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_6787542" ], "products": [ "species_111294", "species_742368" ], "modifiers": [ [ "species_10558230", "catalyst" ] ], "additional_components": [ "WBGene00044903" ] }, "reaction_10558251": { "compartment": "compartment_70101", "id": "reaction_10558251", "reactome": "R-CEL-6787623", "name": "TSTA3 dimer epimerises GDP-DHDMan to GDP-KDGal", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6787618" ], "products": [ "species_6787646" ], "modifiers": [ [ "species_10558248", "catalyst" ] ], "additional_components": [ "G5EER4", "WBGene00019813" ] }, "reaction_10555857": { "compartment": "compartment_7660", "id": "reaction_10555857", "reactome": "R-CEL-5685230", "name": "CHEK1 phosphorylates RAD51", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10555852" ], "products": [ "species_113582", "species_10555855" ], "modifiers": [ [ "species_10502788", "catalyst" ] ], "additional_components": [ "WBGene00004297", "WBGene00004297", "WBGene00000498" ] }, "reaction_10503589": { "compartment": "compartment_5460", "id": "reaction_10503589", "reactome": "R-CEL-70979", "name": "(S)-Malate + NAD+ <=> Oxaloacetate + NADH + H+", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113544", "species_113526" ], "products": [ "species_113529", "species_29362", "species_113587" ], "modifiers": [ [ "species_10503586", "catalyst" ] ], "additional_components": [ "O02640", "WBGene00003162" ] }, "reaction_10504295": { "compartment": "compartment_5460", "id": "reaction_10504295", "reactome": "R-CEL-71775", "name": "GDP + Orthophosphate + Succinyl-CoA <=> GTP + Succinate + CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70958", "species_113548", "species_113525" ], "products": [ "species_29374", "species_113573", "species_113536" ], "modifiers": [ [ "species_10504292", "catalyst" ] ], "additional_components": [ "P53596", "WBGene00007350", "P53589", "WBGene00016844" ] }, "reaction_10503561": { "compartment": "compartment_5460", "id": "reaction_10503561", "reactome": "R-CEL-70967", "name": "isocitrate + NAD+ => alpha-ketoglutarate + CO2 + NADH + H+ [IDH3]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113526", "species_29938" ], "products": [ "species_113594", "species_113529", "species_29362", "species_29376" ], "modifiers": [ [ "species_10503558", "catalyst" ], [ "species_113581", "catalyst" ] ], "additional_components": [ "Q20049", "WBGene00009440", "species_266099", "Q93714", "WBGene00009664", "Q93353", "WBGene00007993" ] }, "reaction_10525994": { "compartment": "compartment_5462", "id": "reaction_10525994", "reactome": "R-CEL-450971", "name": "NADPH + NAD+ + H+ [cytosol] => NADP+ + NADH + H+ [mitochondrial matrix]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_113526", "species_113600" ], "products": [ "species_113563", "species_113529", "species_29362" ], "modifiers": [ [ "species_10525991", "catalyst" ] ], "additional_components": [ "Q18031", "WBGene00003778" ] }, "reaction_10570923": { "compartment": "compartment_5460", "id": "reaction_10570923", "reactome": "R-CEL-9012349", "name": "ME3:Mg2+ tetramer oxidatively decarboxylates MAL to PYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113563", "species_113544" ], "products": [ "species_113529", "species_113557", "species_113600", "species_29376" ], "modifiers": [ [ "species_10570920", "catalyst" ] ], "additional_components": [ "Q9U296", "WBGene00012983", "species_114632" ] }, "reaction_10525996": { "compartment": "compartment_5460", "id": "reaction_10525996", "reactome": "R-CEL-450975", "name": "isocitrate <=> citrate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29938" ], "products": [ "species_29654" ], "modifiers": [ [ "species_10503566", "catalyst" ] ], "additional_components": [ "WBGene00000041" ] }, "reaction_10503628": { "compartment": "compartment_5460", "id": "reaction_10503628", "reactome": "R-CEL-70994", "name": "Succinate <=> Fumarate (with FAD redox reaction on enzyme)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113536" ], "products": [ "species_113588" ], "modifiers": [ [ "species_10503625", "catalyst" ] ], "additional_components": [ "P41956", "WBGene00003225", "Q09508", "WBGene00015391", "species_113596", "O62215", "WBGene00009353", "Q09545", "WBGene00006433" ] }, "reaction_10503599": { "compartment": "compartment_5460", "id": "reaction_10503599", "reactome": "R-CEL-70982", "name": "Fumarate + H2O <=> (S)-Malate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113588", "species_113521" ], "products": [ "species_113544" ], "modifiers": [ [ "species_10503596", "catalyst" ] ], "additional_components": [ "O17214", "WBGene00001503" ] }, "reaction_10570899": { "compartment": "compartment_5460", "id": "reaction_10570899", "reactome": "R-CEL-9012268", "name": "ME2:Mg2+ tetramer oxidatively decarboxylates MAL to PYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113544", "species_113526" ], "products": [ "species_113529", "species_113557", "species_29362", "species_29376" ], "modifiers": [ [ "species_10570896", "catalyst" ], [ "species_113588", "catalyst" ], [ "species_113593", "inhibitor" ] ], "additional_components": [ "species_114632", "Q9U296", "WBGene00012983" ] }, "reaction_10503988": { "compartment": "compartment_5460", "id": "reaction_10503988", "reactome": "R-CEL-71401", "name": "alpha-ketoglutarate + CoASH + NAD+ => succinyl-CoA + CO2 + NADH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_113594", "species_113526" ], "products": [ "species_70958", "species_29362", "species_29376" ], "modifiers": [ [ "species_10503711", "catalyst" ] ], "additional_components": [ "O61199", "WBGene00020679", "species_8878387", "CHEBI:17460", "O45148", "WBGene00020950", "O17953", "WBGene00010794", "species_113596" ] }, "reaction_10526006": { "compartment": "compartment_5460", "id": "reaction_10526006", "reactome": "R-CEL-450984", "name": "isocitrate + NADP+ => alpha-ketoglutarate + CO2 + NADPH + H+ [IDH2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113563", "species_29938" ], "products": [ "species_113594", "species_113529", "species_113600", "species_29376" ], "modifiers": [ [ "species_10526003", "catalyst" ] ], "additional_components": [ "O17643", "WBGene00007942", "species_266099" ] }, "reaction_10503579": { "compartment": "compartment_5460", "id": "reaction_10503579", "reactome": "R-CEL-70975", "name": "Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113559", "species_113587", "species_113521" ], "products": [ "species_29374", "species_29654" ], "modifiers": [ [ "species_10503576", "catalyst" ] ], "additional_components": [ "P34575", "WBGene00000833" ] }, "reaction_10503643": { "compartment": "compartment_5460", "id": "reaction_10503643", "reactome": "R-CEL-70997", "name": "ADP + Orthophosphate + Succinyl-CoA <=> ATP + Succinate + CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70958", "species_113548", "species_113581" ], "products": [ "species_29374", "species_113593", "species_113536" ], "modifiers": [ [ "species_10503640", "catalyst" ] ], "additional_components": [ "P53596", "WBGene00007350", "P53588", "WBGene00009812" ] }, "reaction_10570874": { "compartment": "compartment_5460", "id": "reaction_10570874", "reactome": "R-CEL-9012016", "name": "FAHD1:Zn2+ dimer hydrolyses OA to PYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113587" ], "products": [ "species_113557", "species_29376" ], "modifiers": [ [ "species_10570871", "catalyst" ] ], "additional_components": [ "P34673", "WBGene00022798", "species_114632" ] }, "reaction_10528274": { "compartment": "compartment_5460", "id": "reaction_10528274", "reactome": "R-CEL-880002", "name": "(R)-2-hydroxyglutarate + succinate semialdehyde <=> 2-oxoglutarate + 4-hydroxybutyrate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_880046", "species_879997" ], "products": [ "species_113594", "species_880041" ], "modifiers": [ [ "species_10528271", "catalyst" ] ], "additional_components": [ "WBGene00012608" ] }, "reaction_10528292": { "compartment": "compartment_70616", "id": "reaction_10528292", "reactome": "R-CEL-880050", "name": "(S)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113596", "species_880013" ], "products": [ "species_113594", "species_31649" ], "modifiers": [ [ "species_10528289", "catalyst" ] ], "additional_components": [ "WBGene00021564" ] }, "reaction_10528282": { "compartment": "compartment_5460", "id": "reaction_10528282", "reactome": "R-CEL-880007", "name": "(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113596", "species_879997" ], "products": [ "species_113594", "species_31649" ], "modifiers": [ [ "species_10528279", "catalyst" ], [ "species_880069", "catalyst" ], [ "species_880067", "catalyst" ], [ "species_113527", "catalyst" ] ], "additional_components": [ "WBGene00010055" ] }, "reaction_10563171": { "compartment": "compartment_5460", "id": "reaction_10563171", "reactome": "R-CEL-6807826", "name": "LDHAL6B reduces PYR to LACT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113529", "species_113557", "species_29362" ], "products": [ "species_113526", "species_6807616" ], "modifiers": [ [ "species_10563168", "catalyst" ] ], "additional_components": [ "WBGene00002262" ] }, "reaction_10503986": { "compartment": "compartment_5460", "id": "reaction_10503986", "reactome": "R-CEL-71397", "name": "lipo-PDH decarboxylates PYR to Ac-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_113526", "species_113557" ], "products": [ "species_113559", "species_29362", "species_29376" ], "modifiers": [ [ "species_10503983", "catalyst" ] ], "additional_components": [ "P52899", "WBGene00011510", "O44451", "WBGene00015413", "species_8878387", "Q19749", "WBGene00009082", "O17953", "WBGene00010794", "species_113596" ] }, "reaction_10557975": { "compartment": "compartment_70101", "id": "reaction_10557975", "reactome": "R-CEL-6783221", "name": "HAGH hydrolyses (R)-S-LGSH to GSH and LACT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5694130" ], "products": [ "species_29708", "species_29450" ], "modifiers": [ [ "species_10557972", "catalyst" ] ], "additional_components": [ "species_216785", "Q9XXJ1", "WBGene00012459" ] }, "reaction_10503144": { "compartment": "compartment_70101", "id": "reaction_10503144", "reactome": "R-CEL-70510", "name": "LDH tetramer oxidises LACT to PYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29708", "species_29360" ], "products": [ "species_70106", "species_29398", "species_73473" ], "modifiers": [ [ "species_10503141", "catalyst" ] ], "additional_components": [ "Q27888", "WBGene00002262" ] }, "reaction_10570888": { "compartment": "compartment_70101", "id": "reaction_10570888", "reactome": "R-CEL-9012036", "name": "ME1:Mg2+ tetramer oxidatively decarboxylates MAL to PYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29366", "species_198498" ], "products": [ "species_70106", "species_113528", "species_29398", "species_29364" ], "modifiers": [ [ "species_10570885", "catalyst" ] ], "additional_components": [ "species_114632", "Q9U296", "WBGene00012983" ] }, "reaction_10570839": { "compartment": "compartment_5460", "id": "reaction_10570839", "reactome": "R-CEL-9011543", "name": "DCA binds PDK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9010792", "species_10515600" ], "products": [ "species_10515607" ], "modifiers": [], "additional_components": [ "WBGene00022719", "Q02332", "WBGene00022719" ] }, "reaction_10515609": { "compartment": "compartment_5460", "id": "reaction_10515609", "reactome": "R-CEL-203946", "name": "PDK isoforms phosphorylate lipo-PDH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10503983", "species_113593" ], "products": [ "species_113581", "species_10515593" ], "modifiers": [ [ "species_10515598", "catalyst" ], [ "species_29362", "catalyst" ], [ "species_113559", "catalyst" ], [ "species_10514503", "catalyst" ], [ "species_113557", "inhibitor" ], [ "species_10515607", "inhibitor" ] ], "additional_components": [ "P52899", "WBGene00011510", "O44451", "WBGene00015413", "species_8878387", "Q19749", "WBGene00009082", "O17953", "WBGene00010794", "species_113596", "P52899", "WBGene00011510", "O44451", "WBGene00015413", "species_8878387", "Q19749", "WBGene00009082", "O17953", "WBGene00010794", "species_113596", "WBGene00022719", "Q9XUK7", "WBGene00003675", "P41830", "WBGene00004786", "Q10902", "WBGene00003601", "Q20765", "WBGene00003606", "Q9U2R6", "WBGene00003681", "species_5334816", "Q02332", "WBGene00022719" ] }, "reaction_10570846": { "compartment": "compartment_5460", "id": "reaction_10570846", "reactome": "R-CEL-9011595", "name": "GSTZ1 dimer dehalogenates DCA to glyoxylate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9010792", "species_113521" ], "products": [ "species_904849", "species_3301973" ], "modifiers": [ [ "species_10570843", "catalyst" ], [ "species_1655887", "catalyst" ], [ "species_9010792", "inhibitor" ] ], "additional_components": [ "species_1655887", "Q18938", "WBGene00001790" ] }, "reaction_10515983": { "compartment": "compartment_5460", "id": "reaction_10515983", "reactome": "R-CEL-204169", "name": "PDP dephosphorylates p-lipo-PDH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10515593", "species_113521" ], "products": [ "species_10503983", "species_113548" ], "modifiers": [ [ "species_10515980", "catalyst" ], [ "species_109496", "catalyst" ] ], "additional_components": [ "P52899", "WBGene00011510", "O44451", "WBGene00015413", "species_8878387", "Q19749", "WBGene00009082", "O17953", "WBGene00010794", "species_113596", "P52899", "WBGene00011510", "O44451", "WBGene00015413", "species_8878387", "Q19749", "WBGene00009082", "O17953", "WBGene00010794", "species_113596", "Q9U300", "WBGene00013718", "species_113596", "Q9N4M0", "WBGene00022832" ] }, "reaction_10504332": { "compartment": "compartment_70101", "id": "reaction_10504332", "reactome": "R-CEL-71849", "name": "LDH tetramer reduces PYR to LACT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29398", "species_73473" ], "products": [ "species_29708", "species_29360" ], "modifiers": [ [ "species_10503141", "catalyst" ] ], "additional_components": [ "Q27888", "WBGene00002262" ] }, "reaction_10570926": { "compartment": "compartment_70101", "id": "reaction_10570926", "reactome": "R-CEL-9012374", "name": "VDAC1 transports PYR from cytosol to mitochondrial intermembrane space", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29398" ], "products": [ "species_9012375" ], "modifiers": [ [ "species_10550419", "catalyst" ] ], "additional_components": [ "WBGene00019900" ] }, "reaction_10532289": { "compartment": "compartment_70101", "id": "reaction_10532289", "reactome": "R-CEL-1237096", "name": "Methylthio-ribose-P = Methylthio-ribulose-P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1237165" ], "products": [ "species_1237107" ], "modifiers": [ [ "species_10532286", "catalyst" ] ], "additional_components": [ "WBGene00007236" ] }, "reaction_10532309": { "compartment": "compartment_70101", "id": "reaction_10532309", "reactome": "R-CEL-1237129", "name": "Acireductone is created", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1237176" ], "products": [ "species_29372", "species_70106", "species_1237155" ], "modifiers": [ [ "species_10532306", "catalyst" ] ], "additional_components": [ "Q21012", "WBGene00010286", "species_114632" ] }, "reaction_10532299": { "compartment": "compartment_70101", "id": "reaction_10532299", "reactome": "R-CEL-1237119", "name": "Acireductone is oxidized to MOB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_1237155" ], "products": [ "species_29460", "species_1237122" ], "modifiers": [ [ "species_10532296", "catalyst" ] ], "additional_components": [ "Q20340", "WBGene00009636", "species_113531" ] }, "reaction_10532319": { "compartment": "compartment_70101", "id": "reaction_10532319", "reactome": "R-CEL-1237160", "name": "MTA is cleaved and phosphorylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29372", "species_353106" ], "products": [ "species_1237165", "species_83951" ], "modifiers": [ [ "species_10532316", "catalyst" ] ], "additional_components": [ "Q09438", "WBGene00015064" ] }, "reaction_10510738": { "compartment": "compartment_70616", "id": "reaction_10510738", "reactome": "R-CEL-166214", "name": "FA anion flip-flops to the opposite surface", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10510733" ], "products": [ "species_10510735" ], "modifiers": [ [ "species_10510733", "catalyst" ] ], "additional_components": [ "species_166216", "O01883", "WBGene00006729", "species_166216", "O01883", "WBGene00006729", "species_166216", "O01883", "WBGene00006729" ] }, "reaction_10510740": { "compartment": "compartment_70616", "id": "reaction_10510740", "reactome": "R-CEL-166220", "name": "FA anion diffuses laterally to UCP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10510731", "species_166213" ], "products": [ "species_10510733" ], "modifiers": [], "additional_components": [ "O01883", "WBGene00006729", "species_166216", "O01883", "WBGene00006729" ] }, "reaction_10510742": { "compartment": "compartment_70616", "id": "reaction_10510742", "reactome": "R-CEL-166387", "name": "The FA anion diffuses away laterally from UCP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10510735" ], "products": [ "species_10510731", "species_166216" ], "modifiers": [], "additional_components": [ "species_166216", "O01883", "WBGene00006729", "O01883", "WBGene00006729" ] }, "reaction_10511077": { "compartment": "compartment_70616", "id": "reaction_10511077", "reactome": "R-CEL-170026", "name": "Protons are translocated from the intermembrane space to the matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_163953" ], "products": [ "species_113529" ], "modifiers": [ [ "species_10510731", "catalyst" ], [ "species_30495", "catalyst" ], [ "species_170037", "inhibitor" ] ], "additional_components": [ "O01883", "WBGene00006729", "species_29358", "species_113582", "species_29420", "species_29438" ] }, "reaction_10567812": { "compartment": "compartment_7660", "id": "reaction_10567812", "reactome": "R-CEL-8878143", "name": "RUNX3 binds SMAD3 and SMAD4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10566205", "species_10567808" ], "products": [ "species_10567810" ], "modifiers": [], "additional_components": [ "WBGene00004393", "P45897", "WBGene00004858", "Q21733", "WBGene00000904", "P45897", "WBGene00004858", "Q21733", "WBGene00000904", "G5EFQ5", "WBGene00004393" ] }, "reaction_10567805": { "compartment": "compartment_7660", "id": "reaction_10567805", "reactome": "R-CEL-8878117", "name": "RUNX3 binds ZFHX3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10566205", "species_10567801" ], "products": [ "species_10567803" ], "modifiers": [ [ "species_10511431", "catalyst" ] ], "additional_components": [ "WBGene00004393", "WBGene00022518", "V6CLN5", "WBGene00022518", "G5EFQ5", "WBGene00004393", "G5EBY8", "WBGene00006852", "G5EEL5", "WBGene00000936" ] }, "reaction_10520769": { "compartment": "compartment_17951", "id": "reaction_10520769", "reactome": "R-CEL-390256", "name": "hexacosanoyl-CoA + O2 => trans-2,3-dehydrohexacosanoyl-CoA + H2O2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113535", "species_390260" ], "products": [ "species_390249", "species_113575" ], "modifiers": [ [ "species_10520766", "catalyst" ] ], "additional_components": [ "species_113596", "O62138", "WBGene00008566" ] }, "reaction_10520758": { "compartment": "compartment_17951", "id": "reaction_10520758", "reactome": "R-CEL-390251", "name": "HSD17B4 dehydrogenates 3-hydroxyhexacosanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_390248", "species_192307" ], "products": [ "species_193465", "species_390241", "species_192305" ], "modifiers": [ [ "species_10513270", "catalyst" ] ], "additional_components": [ "Q19058", "WBGene00017123" ] }, "reaction_10520808": { "compartment": "compartment_17947", "id": "reaction_10520808", "reactome": "R-CEL-390393", "name": "Peroxisomal uptake of very long-chain fatty acyl CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_390394" ], "products": [ "species_390260" ], "modifiers": [ [ "species_10520381", "catalyst" ] ], "additional_components": [ "O45730", "WBGene00004061" ] }, "reaction_10520760": { "compartment": "compartment_17951", "id": "reaction_10520760", "reactome": "R-CEL-390252", "name": "HSD17B4 hydrates trans-2,3-dehydrohexacosanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_141343", "species_390249" ], "products": [ "species_390248" ], "modifiers": [ [ "species_10513270", "catalyst" ] ], "additional_components": [ "Q19058", "WBGene00017123" ] }, "reaction_10563641": { "compartment": "compartment_17951", "id": "reaction_10563641", "reactome": "R-CEL-6809263", "name": "EHHADH hydrates trans-2,3-dehydrohexacosanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_141343", "species_390249" ], "products": [ "species_390248" ], "modifiers": [ [ "species_10563638", "catalyst" ] ], "additional_components": [ "WBGene00001157" ] }, "reaction_10556490": { "compartment": "compartment_17951", "id": "reaction_10556490", "reactome": "R-CEL-5690042", "name": "Peroxisomal ACOT4,6,8 hydrolyse MCFA-CoA, LCFA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5690520", "species_141343" ], "products": [ "species_5690539", "species_193514" ], "modifiers": [ [ "species_10556487", "catalyst" ] ], "additional_components": [ "species_164991", "species_5690542", "species_5690531", "species_174602", "O45003", "WBGene00020989", "Q9GYN3", "WBGene00020989", "B3WFZ3", "WBGene00020989", "O01862", "WBGene00020989", "Q9BIA9", "WBGene00015887" ] }, "reaction_10530620": { "compartment": "compartment_17951", "id": "reaction_10530620", "reactome": "R-CEL-977317", "name": "malonyl-CoA is decarboxylated to acetyl-CoA in peroxisome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_977323" ], "products": [ "species_353123", "species_389536" ], "modifiers": [ [ "species_10530617", "catalyst" ] ], "additional_components": [ "WBGene00009439" ] }, "reaction_10563644": { "compartment": "compartment_17951", "id": "reaction_10563644", "reactome": "R-CEL-6809264", "name": "EHHADH dehydrogenates 3-hydroxyhexacosanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_390248", "species_192307" ], "products": [ "species_193465", "species_390241", "species_192305" ], "modifiers": [ [ "species_10563638", "catalyst" ] ], "additional_components": [ "WBGene00001157" ] }, "reaction_10520641": { "compartment": "compartment_17951", "id": "reaction_10520641", "reactome": "R-CEL-389632", "name": "pristanate + CoA-SH + ATP => pristanoyl-CoA + AMP + pyrophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6811612", "species_193514", "species_389573" ], "products": [ "species_389593", "species_389569", "species_389620" ], "modifiers": [ [ "species_10520635", "catalyst" ] ], "additional_components": [ "Q18916", "WBGene00017012", "Q19878", "WBGene00009218" ] }, "reaction_10520629": { "compartment": "compartment_17951", "id": "reaction_10520629", "reactome": "R-CEL-389611", "name": "2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_389594" ], "products": [ "species_389578", "species_389636" ], "modifiers": [ [ "species_10520626", "catalyst" ] ], "additional_components": [ "species_8878387", "species_114632", "Q17474", "WBGene00007143" ] }, "reaction_10520617": { "compartment": "compartment_17951", "id": "reaction_10520617", "reactome": "R-CEL-389609", "name": "ALDH3A2-2 oxidizes pristanal to pristanate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_389636", "species_192307" ], "products": [ "species_193465", "species_6811612", "species_192305" ], "modifiers": [ [ "species_10520614", "catalyst" ] ], "additional_components": [ "O44555", "WBGene00000111", "A0A486WWU7", "WBGene00000110" ] }, "reaction_10520651": { "compartment": "compartment_17951", "id": "reaction_10520651", "reactome": "R-CEL-389639", "name": "phytanoyl-CoA + 2-oxoglutarate + O2 => 2-hydroxyphytanoyl-CoA + succinate + CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113535", "species_389615", "species_389537" ], "products": [ "species_389594", "species_389583", "species_389536" ], "modifiers": [ [ "species_10520648", "catalyst" ] ], "additional_components": [ "O62515", "WBGene00014000", "species_113531" ] }, "reaction_10520638": { "compartment": "compartment_17951", "id": "reaction_10520638", "reactome": "R-CEL-389622", "name": "phytanate + CoA-SH + ATP => phytanoyl-CoA + AMP + pyrophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_389596", "species_193514", "species_389573" ], "products": [ "species_389593", "species_389615", "species_389620" ], "modifiers": [ [ "species_10520635", "catalyst" ] ], "additional_components": [ "Q18916", "WBGene00017012", "Q19878", "WBGene00009218" ] }, "reaction_10564665": { "compartment": "compartment_17947", "id": "reaction_10564665", "reactome": "R-CEL-8848247", "name": "ACBD4,5 bind MCFA-CoA and LCFA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5690520", "species_10564661" ], "products": [ "species_10564663" ], "modifiers": [], "additional_components": [ "species_164991", "species_5690542", "A0A1D3PCN1", "WBGene00270319", "Q9XTZ5", "WBGene00007680", "A0A1D3PCN1", "WBGene00270319", "Q9XTZ5", "WBGene00007680", "species_164991", "species_5690542" ] }, "reaction_10558271": { "compartment": "compartment_17951", "id": "reaction_10558271", "reactome": "R-CEL-6787811", "name": "HAO2 tetramer oxidises 2OH-PALM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113535", "species_6787810" ], "products": [ "species_113575", "species_6787814" ], "modifiers": [ [ "species_10558268", "catalyst" ] ], "additional_components": [ "B1GRK5", "WBGene00018286" ] }, "reaction_10563806": { "compartment": "compartment_17951", "id": "reaction_10563806", "reactome": "R-CEL-6810474", "name": "NUDT19 hydrolyses acyl-CoA to 3',5'-ADP and acyl-PPANT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_141343", "species_6810523" ], "products": [ "species_6809360", "species_6810530" ], "modifiers": [ [ "species_10563803", "catalyst" ] ], "additional_components": [ "WBGene00003584" ] }, "reaction_10516209": { "compartment": "compartment_70101", "id": "reaction_10516209", "reactome": "R-CEL-205136", "name": "GTP-bound RAC contributes to JNK activation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10510931" ], "products": [ "species_29370", "species_10510951" ], "modifiers": [ [ "species_10516065", "catalyst" ] ], "additional_components": [ "WBGene00002178", "WBGene00002178", "Q03206", "ced-10", "species_29438" ] }, "reaction_10516179": { "compartment": "compartment_70101", "id": "reaction_10516179", "reactome": "R-CEL-205039", "name": "p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10516063", "species_29438" ], "products": [ "species_29420", "species_10516065" ], "modifiers": [ [ "species_10516176", "catalyst" ] ], "additional_components": [ "species_29420", "Q03206", "ced-10", "Q03206", "ced-10", "species_29438", "G5EFE1", "WBGene00006468", "H2L0P5", "WBGene00022391", "G5EF62", "WBGene00009337", "Q9U3P2", "WBGene00007750", "X5LV34", "WBGene00001366", "S6EZU2", "WBGene00006476", "Q45FX5", "WBGene00006887", "Q21653", "WBGene00019832", "A0A0K3AQN0", "WBGene00013682", "O01847", "WBGene00015704", "Q965J0", "WBGene00019487", "Q21430", "WBGene00010776", "H2KYI7", "WBGene00006496", "Q9N5D3", "WBGene00004947", "Q9U364", "WBGene00002297", "A0A0K3AS36", "Y116A8C.36d", "Q19572", "WBGene00001674", "species_29438" ] }, "reaction_10513418": { "compartment": "compartment_13231", "id": "reaction_10513418", "reactome": "R-CEL-193666", "name": "Active JNK moves to the nucleus and phosphorylates different transcription factors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10510951" ], "products": [ "species_10510872" ], "modifiers": [], "additional_components": [ "WBGene00002178", "WBGene00002178" ] }, "reaction_10523262": { "compartment": "compartment_70101", "id": "reaction_10523262", "reactome": "R-CEL-428750", "name": "Gq activation by TP receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10523257" ], "products": [ "species_29420", "species_10523259" ], "modifiers": [ [ "species_10523257", "catalyst" ] ], "additional_components": [ "CHEBI:15627", "species_29420", "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "CHEBI:15627", "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196", "species_29438", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "CHEBI:15627", "species_29420", "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196", "P17343", "WBGene00001679", "P54406", "WBGene00001681" ] }, "reaction_10523342": { "compartment": "compartment_70101", "id": "reaction_10523342", "reactome": "R-CEL-428917", "name": "G13 activation by TP receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10523337" ], "products": [ "species_29420", "species_10523339" ], "modifiers": [ [ "species_10523337", "catalyst" ] ], "additional_components": [ "species_29420", "Q19572", "WBGene00001674", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "CHEBI:15627", "CHEBI:15627", "Q19572", "WBGene00001674", "species_29438", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "species_29420", "Q19572", "WBGene00001674", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "CHEBI:15627" ] }, "reaction_10546012": { "compartment": "compartment_7660", "id": "reaction_10546012", "reactome": "R-CEL-2990833", "name": "Conjugation of SUMO1 to UBA2:SAE1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10545999", "species_29358", "species_10528096" ], "products": [ "species_164121", "species_10546009", "species_113541" ], "modifiers": [ [ "species_10545999", "catalyst" ] ], "additional_components": [ "Q17820", "WBGene00000142", "Q9NAN1", "WBGene00006700", "WBGene00004888", "Q9NAN1", "WBGene00006700", "P55853", "WBGene00004888", "Q17820", "WBGene00000142", "Q17820", "WBGene00000142", "Q9NAN1", "WBGene00006700" ] }, "reaction_10546368": { "compartment": "compartment_7660", "id": "reaction_10546368", "reactome": "R-CEL-3108212", "name": "SMC5-SMC6 Complex SUMOylates Cohesin with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10544476", "species_10546081" ], "products": [ "species_10546332", "species_10546073" ], "modifiers": [ [ "species_10546365", "catalyst" ] ], "additional_components": [ "B2FDA8", "WBGene00004873", "Q19325", "WBGene00004737", "Q9XUB3", "WBGene00004333", "Q19555", "WBGene00004738", "O01789", "WBGene00001860", "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "B2FDA8", "WBGene00004873", "Q19325", "WBGene00004737", "Q9XUB3", "WBGene00004333", "P55853", "WBGene00004888", "Q19555", "WBGene00004738", "O01789", "WBGene00001860", "WBGene00006706", "G5EG17", "WBGene00010056", "P91501", "WBGene00020843", "Q23420", "WBGene00022881", "Q9XTV3", "WBGene00010409", "Q18237", "WBGene00016151" ] }, "reaction_10549336": { "compartment": "compartment_7660", "id": "reaction_10549336", "reactome": "R-CEL-4570554", "name": "SUMOylation of MDC1 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10549326", "species_10546081" ], "products": [ "species_10546073", "species_10549334" ], "modifiers": [ [ "species_10546081", "catalyst" ] ], "additional_components": [ "WBGene00004031", "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "WBGene00006706", "P55853", "WBGene00004888", "Q9U370", "WBGene00004031", "Q95017", "WBGene00006706", "P55853", "WBGene00004888" ] }, "reaction_10549321": { "compartment": "compartment_7660", "id": "reaction_10549321", "reactome": "R-CEL-4570528", "name": "SUMOylation of XPC with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10549311", "species_10546081" ], "products": [ "species_10546073", "species_10549319" ], "modifiers": [ [ "species_10546081", "catalyst" ] ], "additional_components": [ "WBGene00022296", "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "WBGene00006706", "Q9N4C3", "WBGene00022296", "P55853", "WBGene00004888", "Q95017", "WBGene00006706", "P55853", "WBGene00004888" ] }, "reaction_10546235": { "compartment": "compartment_7660", "id": "reaction_10546235", "reactome": "R-CEL-3000383", "name": "UBE2I, HDAC7 SUMOylate PML with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546215", "species_10546081" ], "products": [ "species_10546073", "species_10546225" ], "modifiers": [ [ "species_10546232", "catalyst" ] ], "additional_components": [ "WBGene00006523", "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "WBGene00006706", "G5ED20", "WBGene00006523", "P55853", "WBGene00004888", "O17323", "WBGene00001837", "Q95017", "WBGene00006706" ] }, "reaction_10549243": { "compartment": "compartment_7660", "id": "reaction_10549243", "reactome": "R-CEL-4551661", "name": "PIAS4 SUMOylates RNF168 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546081", "species_10549233" ], "products": [ "species_10546073", "species_10549241" ], "modifiers": [ [ "species_10546168", "catalyst" ] ], "additional_components": [ "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "WBGene00011366", "WBGene00006706", "P55853", "WBGene00004888", "Q7YWU1", "WBGene00011366", "Q21970", "WBGene00011259", "Q94361", "WBGene00001574" ] }, "reaction_10546173": { "compartment": "compartment_7660", "id": "reaction_10546173", "reactome": "R-CEL-2997709", "name": "PIAS1,4 SUMOylates BRCA1 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546154", "species_10546081" ], "products": [ "species_10546073", "species_10546162" ], "modifiers": [ [ "species_10546170", "catalyst" ] ], "additional_components": [ "WBGene00000264", "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "WBGene00006706", "P55853", "WBGene00004888", "B6VQ60", "WBGene00000264", "Q21970", "WBGene00011259", "Q94361", "WBGene00001574" ] }, "reaction_10549255": { "compartment": "compartment_7660", "id": "reaction_10549255", "reactome": "R-CEL-4551721", "name": "PIAS4 SUMOylates VHL with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10532238", "species_10546081" ], "products": [ "species_10546073", "species_10549253" ], "modifiers": [ [ "species_10546168", "catalyst" ] ], "additional_components": [ "WBGene00006922", "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "WBGene00006706", "Q19213", "WBGene00006922", "P55853", "WBGene00004888", "Q21970", "WBGene00011259", "Q94361", "WBGene00001574" ] }, "reaction_10546769": { "compartment": "compartment_7660", "id": "reaction_10546769", "reactome": "R-CEL-3247493", "name": "PIAS1 SUMOylates SP3 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546758", "species_10546081" ], "products": [ "species_10546766", "species_10546073" ], "modifiers": [ [ "species_10528091", "catalyst" ] ], "additional_components": [ "WBGene00012735", "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "Q9XW26", "WBGene00012735", "P55853", "WBGene00004888", "WBGene00006706", "Q21970", "WBGene00011259", "Q94361", "WBGene00001574" ] }, "reaction_10546189": { "compartment": "compartment_7660", "id": "reaction_10546189", "reactome": "R-CEL-2997723", "name": "PIAS4 SUMOylates TP53BP1 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546178", "species_10546081" ], "products": [ "species_10546186", "species_10546073" ], "modifiers": [ [ "species_10546168", "catalyst" ] ], "additional_components": [ "WBGene00002027", "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "Q7JKP6", "WBGene00002027", "P55853", "WBGene00004888", "WBGene00006706", "Q21970", "WBGene00011259", "Q94361", "WBGene00001574" ] }, "reaction_10546734": { "compartment": "compartment_7660", "id": "reaction_10546734", "reactome": "R-CEL-3232162", "name": "PIAS3 SUMOylates MITF with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546716", "species_10546081" ], "products": [ "species_10546073", "species_10546725" ], "modifiers": [ [ "species_10546731", "catalyst" ] ], "additional_components": [ "WBGene00020930", "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "WBGene00006706", "H2KZZ2", "WBGene00020930", "P55853", "WBGene00004888", "Q21970", "WBGene00011259", "Q94361", "WBGene00001574" ] }, "reaction_10549296": { "compartment": "compartment_7660", "id": "reaction_10549296", "reactome": "R-CEL-4570467", "name": "SUMOylation of NOP58 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10549285", "species_10546081" ], "products": [ "species_10549294", "species_10546073" ], "modifiers": [ [ "species_10546081", "catalyst" ] ], "additional_components": [ "WBGene00020915", "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "P55853", "WBGene00004888", "O45012", "WBGene00020915", "WBGene00006706", "Q95017", "WBGene00006706", "P55853", "WBGene00004888" ] }, "reaction_10548368": { "compartment": "compartment_7660", "id": "reaction_10548368", "reactome": "R-CEL-3900177", "name": "SUMOylation of DDX5 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10504695", "species_10546081" ], "products": [ "species_10548366", "species_10546073" ], "modifiers": [ [ "species_10546081", "catalyst" ] ], "additional_components": [ "WBGene00010260", "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "P55853", "WBGene00004888", "Q9XUW5", "WBGene00010260", "WBGene00006706", "Q95017", "WBGene00006706", "P55853", "WBGene00004888" ] }, "reaction_10548945": { "compartment": "compartment_7660", "id": "reaction_10548945", "reactome": "R-CEL-4085331", "name": "PIAS2-1 SUMOylates PARK7 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10548932", "species_10546081" ], "products": [ "species_10548940", "species_10546073" ], "modifiers": [ [ "species_10548942", "catalyst" ] ], "additional_components": [ "WBGene00015184", "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "P55853", "WBGene00004888", "P90994", "WBGene00015184", "WBGene00006706", "WBGene00001574" ] }, "reaction_10548961": { "compartment": "compartment_7660", "id": "reaction_10548961", "reactome": "R-CEL-4085347", "name": "PIAS1 SUMOylates SAFB with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10548950", "species_10546081" ], "products": [ "species_10548959", "species_10546073" ], "modifiers": [ [ "species_10528091", "catalyst" ] ], "additional_components": [ "WBGene00009314", "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "P55853", "WBGene00004888", "O62203", "WBGene00009314", "WBGene00006706", "Q21970", "WBGene00011259", "Q94361", "WBGene00001574" ] }, "reaction_10549026": { "compartment": "compartment_7660", "id": "reaction_10549026", "reactome": "R-CEL-4090284", "name": "SUMOylation of HIPK2 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10549016", "species_10546081" ], "products": [ "species_10546073", "species_10549024" ], "modifiers": [ [ "species_10546081", "catalyst" ] ], "additional_components": [ "WBGene00001994", "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "WBGene00006706", "P55853", "WBGene00004888", "Q8MQ70", "WBGene00001994", "Q95017", "WBGene00006706", "P55853", "WBGene00004888" ] }, "reaction_10548179": { "compartment": "compartment_7660", "id": "reaction_10548179", "reactome": "R-CEL-3782535", "name": "TRIM28 SUMOylates TRIM28:ZNF350 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10548151", "species_10546081" ], "products": [ "species_10546073", "species_10548176" ], "modifiers": [ [ "species_10529660", "catalyst" ] ], "additional_components": [ "Q9N5S3", "WBGene00003087", "O46016", "WBGene00013970", "B7WNA2", "WBGene00010264", "Q19418", "WBGene00008762", "H2L008", "WBGene00019960", "Q9BLC4", "WBGene00017406", "O02050", "WBGene00022592", "H2L0K3", "WBGene00003599", "Q19818", "WBGene00003598", "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "WBGene00006706", "Q9N5S3", "WBGene00003087", "O46016", "WBGene00013970", "B7WNA2", "WBGene00010264", "Q19418", "WBGene00008762", "H2L008", "WBGene00019960", "Q9BLC4", "WBGene00017406", "O02050", "WBGene00022592", "Q19818", "WBGene00003598", "H2L0K3", "WBGene00003599", "P55853", "WBGene00004888", "H2L0K3", "WBGene00003599", "Q19818", "WBGene00003598" ] }, "reaction_10548358": { "compartment": "compartment_7660", "id": "reaction_10548358", "reactome": "R-CEL-3900047", "name": "SUMOylation of DDX17 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10548348", "species_10546081" ], "products": [ "species_10546073", "species_10548356" ], "modifiers": [ [ "species_10546081", "catalyst" ] ], "additional_components": [ "WBGene00010260", "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "WBGene00006706", "Q9XUW5", "WBGene00010260", "P55853", "WBGene00004888", "Q95017", "WBGene00006706", "P55853", "WBGene00004888" ] }, "reaction_10548346": { "compartment": "compartment_7660", "id": "reaction_10548346", "reactome": "R-CEL-3899291", "name": "SUMOylation of EP300 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10532228", "species_10546081" ], "products": [ "species_10546073", "species_10548344" ], "modifiers": [ [ "species_10546081", "catalyst" ] ], "additional_components": [ "WBGene00000366", "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "WBGene00006706", "P55853", "WBGene00004888", "P34545", "WBGene00000366", "Q95017", "WBGene00006706", "P55853", "WBGene00004888" ] }, "reaction_10549506": { "compartment": "compartment_7660", "id": "reaction_10549506", "reactome": "R-CEL-4641362", "name": "SUMOylation of TOP1 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10549496", "species_10546081" ], "products": [ "species_10546073", "species_10549504" ], "modifiers": [ [ "species_10546081", "catalyst" ] ], "additional_components": [ "WBGene00006595", "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "WBGene00006706", "O17966", "WBGene00006595", "P55853", "WBGene00004888", "Q95017", "WBGene00006706", "P55853", "WBGene00004888" ] }, "reaction_10549491": { "compartment": "compartment_7660", "id": "reaction_10549491", "reactome": "R-CEL-4641345", "name": "SUMOylation of TOP2B with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10549474", "species_10546081" ], "products": [ "species_10546073", "species_10549489" ], "modifiers": [ [ "species_10546081", "catalyst" ] ], "additional_components": [ "Q23670", "WBGene00010785", "G5ECQ8", "WBGene00022854", "P34534", "WBGene00019884", "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "WBGene00006706", "G5ECQ8", "WBGene00022854", "P34534", "WBGene00019884", "Q23670", "WBGene00010785", "P55853", "WBGene00004888", "Q95017", "WBGene00006706", "P55853", "WBGene00004888" ] }, "reaction_10549460": { "compartment": "compartment_7660", "id": "reaction_10549460", "reactome": "R-CEL-4641342", "name": "SUMOylation of TOP2A with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10549450", "species_10546081" ], "products": [ "species_10546073", "species_10549458" ], "modifiers": [ [ "species_10546081", "catalyst" ] ], "additional_components": [ "WBGene00019884", "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "WBGene00006706", "P55853", "WBGene00004888", "P34534", "WBGene00019884", "Q95017", "WBGene00006706", "P55853", "WBGene00004888" ] }, "reaction_10549415": { "compartment": "compartment_7660", "id": "reaction_10549415", "reactome": "R-CEL-4615910", "name": "SUMOylation of PCNA with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502651", "species_10546081" ], "products": [ "species_10546073", "species_10549413" ], "modifiers": [ [ "species_10546081", "catalyst" ] ], "additional_components": [ "WBGene00003955", "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "WBGene00006706", "O02115", "WBGene00003955", "P55853", "WBGene00004888", "Q95017", "WBGene00006706", "P55853", "WBGene00004888" ] }, "reaction_10548917": { "compartment": "compartment_7660", "id": "reaction_10548917", "reactome": "R-CEL-3968362", "name": "SUMOylation of PIAS4 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546168", "species_10546081" ], "products": [ "species_10546073", "species_10548915" ], "modifiers": [ [ "species_10546081", "catalyst" ] ], "additional_components": [ "Q21970", "WBGene00011259", "Q94361", "WBGene00001574", "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "WBGene00006706", "Q21970", "WBGene00011259", "Q94361", "WBGene00001574", "P55853", "WBGene00004888", "Q95017", "WBGene00006706", "P55853", "WBGene00004888" ] }, "reaction_10548971": { "compartment": "compartment_7660", "id": "reaction_10548971", "reactome": "R-CEL-4085350", "name": "SUMOylation of UBE2I with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546073", "species_10546081" ], "products": [ "species_10546073", "species_10548969" ], "modifiers": [ [ "species_10546081", "catalyst" ] ], "additional_components": [ "WBGene00006706", "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "WBGene00006706", "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "Q95017", "WBGene00006706", "P55853", "WBGene00004888" ] }, "reaction_10546255": { "compartment": "compartment_13231", "id": "reaction_10546255", "reactome": "R-CEL-3000449", "name": "UBC9 (UBE2I) SUMOylates RANGAP1 with SUMO, which targets RANGAP1 to RANBP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546242", "species_10546081" ], "products": [ "species_10546252", "species_10546073" ], "modifiers": [ [ "species_10546081", "catalyst" ] ], "additional_components": [ "P34342", "WBGene00004303", "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "P34342", "WBGene00004303", "P55853", "WBGene00004888", "WBGene00006706", "Q95017", "WBGene00006706", "P55853", "WBGene00004888" ] }, "reaction_10509888": { "compartment": "compartment_70101", "id": "reaction_10509888", "reactome": "R-CEL-156808", "name": "Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a 'closed-loop' conformation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10505614", "species_10509884", "species_10509879", "species_10505637" ], "products": [ "species_10505614", "species_10509886" ], "modifiers": [], "additional_components": [ "WBGene00019162", "WBGene00003902", "A0A486WX07", "WBGene00002066", "Q20935", "WBGene00018997", "P27639", "WBGene00002083", "O61955", "WBGene00002061", "H2L0A8", "WBGene00019157", "species_29438", "Q9BKU3", "WBGene00021351", "Q21230", "WBGene00010560", "Q95XR0", "WBGene00021466", "P51403", "WBGene00004471", "Q9NEN6", "WBGene00004475", "Q8WQA8", "WBGene00004489", "Q23312", "WBGene00004476", "O01869", "WBGene00004479", "P49197", "WBGene00004490", "P48156", "WBGene00004477", "Q20206", "WBGene00004480", "Q19877", "WBGene00004492", "Q20228", "WBGene00004478", "P49196", "WBGene00004481", "Q1XFY9", "WBGene00004493", "P46769", "WBGene00004469", "P51404", "WBGene00004482", "P52821", "WBGene00004494", "Q9TXP0", "WBGene00004496", "P48150", "WBGene00004483", "O45499", "WBGene00004495", "Q9N3X2", "WBGene00004473", "Q9XVP0", "WBGene00004484", "Q95Y04", "WBGene00004497", "Q22054", "WBGene00004485", "P90983", "WBGene00004498", "O01692", "WBGene00004486", "P48152", "WBGene00004472", "O18240", "WBGene00004487", "O18650", "WBGene00004488", "P48154", "WBGene00004470", "O17218", "WBGene00004491", "P49041", "WBGene00004474", "Q95QW0", "WBGene00015920", "O01974", "WBGene00001231", "Q94261", "WBGene00019543", "P34339", "WBGene00001209", "Q9XWP7", "WBGene00012738", "P30642", "WBGene00001227", "Q965S8", "WBGene00001232", "O02328", "WBGene00001226", "Q19706", "WBGene00001230", "O61820", "WBGene00001228", "Q18967", "WBGene00001229", "Q9XUP3", "WBGene00001233", "Q9XWI6", "WBGene00001225", "Q9TXU7", "WBGene00019162", "WBGene00019162", "A0A486WX07", "WBGene00002066", "Q20935", "WBGene00018997", "P27639", "WBGene00002083", "O61955", "WBGene00002061", "species_29438", "Q9BKU3", "WBGene00021351", "Q21230", "WBGene00010560", "Q95XR0", "WBGene00021466", "P51403", "WBGene00004471", "Q9NEN6", "WBGene00004475", "Q8WQA8", "WBGene00004489", "Q23312", "WBGene00004476", "O01869", "WBGene00004479", "P49197", "WBGene00004490", "P48156", "WBGene00004477", "Q20206", "WBGene00004480", "Q19877", "WBGene00004492", "Q20228", "WBGene00004478", "P49196", "WBGene00004481", "Q1XFY9", "WBGene00004493", "P46769", "WBGene00004469", "P51404", "WBGene00004482", "P52821", "WBGene00004494", "Q9TXP0", "WBGene00004496", "P48150", "WBGene00004483", "O45499", "WBGene00004495", "Q9N3X2", "WBGene00004473", "Q9XVP0", "WBGene00004484", "Q95Y04", "WBGene00004497", "Q22054", "WBGene00004485", "P90983", "WBGene00004498", "O01692", "WBGene00004486", "P48152", "WBGene00004472", "O18240", "WBGene00004487", "O18650", "WBGene00004488", "P48154", "WBGene00004470", "O17218", "WBGene00004491", "P49041", "WBGene00004474", "Q95QW0", "WBGene00015920", "O01974", "WBGene00001231", "Q94261", "WBGene00019543", "P34339", "WBGene00001209", "Q9XWP7", "WBGene00012738", "P30642", "WBGene00001227", "Q965S8", "WBGene00001232", "O02328", "WBGene00001226", "Q19706", "WBGene00001230", "O61820", "WBGene00001228", "Q18967", "WBGene00001229", "Q9XUP3", "WBGene00001233", "Q9XWI6", "WBGene00001225", "Q9TXU7", "WBGene00019162", "H2L0A8", "WBGene00019157", "Q9U302", "WBGene00003902" ] }, "reaction_10509927": { "compartment": "compartment_70101", "id": "reaction_10509927", "reactome": "R-CEL-157849", "name": "Formation of translation initiation complexes containing mRNA that does not circularize", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10505614", "species_10509925", "species_10505637" ], "products": [ "species_10505614", "species_10505676" ], "modifiers": [], "additional_components": [ "WBGene00019162", "A0A486WX07", "WBGene00002066", "Q20935", "WBGene00018997", "P27639", "WBGene00002083", "O61955", "WBGene00002061", "H2L0A8", "WBGene00019157", "species_29438", "Q9BKU3", "WBGene00021351", "Q21230", "WBGene00010560", "Q95XR0", "WBGene00021466", "P51403", "WBGene00004471", "Q9NEN6", "WBGene00004475", "Q8WQA8", "WBGene00004489", "Q23312", "WBGene00004476", "O01869", "WBGene00004479", "P49197", "WBGene00004490", "P48156", "WBGene00004477", "Q20206", "WBGene00004480", "Q19877", "WBGene00004492", "Q20228", "WBGene00004478", "P49196", "WBGene00004481", "Q1XFY9", "WBGene00004493", "P46769", "WBGene00004469", "P51404", "WBGene00004482", "P52821", "WBGene00004494", "Q9TXP0", "WBGene00004496", "P48150", "WBGene00004483", "O45499", "WBGene00004495", "Q9N3X2", "WBGene00004473", "Q9XVP0", "WBGene00004484", "Q95Y04", "WBGene00004497", "Q22054", "WBGene00004485", "P90983", "WBGene00004498", "O01692", "WBGene00004486", "P48152", "WBGene00004472", "O18240", "WBGene00004487", "O18650", "WBGene00004488", "P48154", "WBGene00004470", "O17218", "WBGene00004491", "P49041", "WBGene00004474", "Q95QW0", "WBGene00015920", "O01974", "WBGene00001231", "Q94261", "WBGene00019543", "P34339", "WBGene00001209", "Q9XWP7", "WBGene00012738", "P30642", "WBGene00001227", "Q965S8", "WBGene00001232", "O02328", "WBGene00001226", "Q19706", "WBGene00001230", "O61820", "WBGene00001228", "Q18967", "WBGene00001229", "Q9XUP3", "WBGene00001233", "Q9XWI6", "WBGene00001225", "Q9TXU7", "WBGene00019162", "WBGene00019162", "A0A486WX07", "WBGene00002066", "Q20935", "WBGene00018997", "P27639", "WBGene00002083", "O61955", "WBGene00002061", "species_29438", "Q9BKU3", "WBGene00021351", "Q21230", "WBGene00010560", "Q95XR0", "WBGene00021466", "P51403", "WBGene00004471", "Q9NEN6", "WBGene00004475", "Q8WQA8", "WBGene00004489", "Q23312", "WBGene00004476", "O01869", "WBGene00004479", "P49197", "WBGene00004490", "P48156", "WBGene00004477", "Q20206", "WBGene00004480", "Q19877", "WBGene00004492", "Q20228", "WBGene00004478", "P49196", "WBGene00004481", "Q1XFY9", "WBGene00004493", "P46769", "WBGene00004469", "P51404", "WBGene00004482", "P52821", "WBGene00004494", "Q9TXP0", "WBGene00004496", "P48150", "WBGene00004483", "O45499", "WBGene00004495", "Q9N3X2", "WBGene00004473", "Q9XVP0", "WBGene00004484", "Q95Y04", "WBGene00004497", "Q22054", "WBGene00004485", "P90983", "WBGene00004498", "O01692", "WBGene00004486", "P48152", "WBGene00004472", "O18240", "WBGene00004487", "O18650", "WBGene00004488", "P48154", "WBGene00004470", "O17218", "WBGene00004491", "P49041", "WBGene00004474", "Q95QW0", "WBGene00015920", "O01974", "WBGene00001231", "Q94261", "WBGene00019543", "P34339", "WBGene00001209", "Q9XWP7", "WBGene00012738", "P30642", "WBGene00001227", "Q965S8", "WBGene00001232", "O02328", "WBGene00001226", "Q19706", "WBGene00001230", "O61820", "WBGene00001228", "Q18967", "WBGene00001229", "Q9XUP3", "WBGene00001233", "Q9XWI6", "WBGene00001225", "Q9TXU7", "WBGene00019162", "H2L0A8", "WBGene00019157" ] }, "reaction_10549921": { "compartment": "compartment_876", "id": "reaction_10549921", "reactome": "R-CEL-5138441", "name": "WNT5A-FZD4 recruits DVL2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10549898", "species_10515048" ], "products": [ "species_10549902" ], "modifiers": [], "additional_components": [ "Q9N532", "WBGene00003238", "G5EDV1", "WBGene00003006", "P34889", "WBGene00000858", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "Q9N532", "WBGene00003238", "G5EDV1", "WBGene00003006", "P34889", "WBGene00000858" ] }, "reaction_10549909": { "compartment": "compartment_876", "id": "reaction_10549909", "reactome": "R-CEL-5138432", "name": "DVL2 is phosphorylated by PKC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10549902", "species_113592" ], "products": [ "species_29370", "species_10549904" ], "modifiers": [ [ "species_10549906", "catalyst" ] ], "additional_components": [ "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "Q9N532", "WBGene00003238", "G5EDV1", "WBGene00003006", "P34889", "WBGene00000858", "Q9N532", "WBGene00003238", "G5EDV1", "WBGene00003006", "P34889", "WBGene00000858", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241" ] }, "reaction_10549900": { "compartment": "compartment_876", "id": "reaction_10549900", "reactome": "R-CEL-5099899", "name": "WNT5A binds FZD4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546954", "species_10548869" ], "products": [ "species_10549898" ], "modifiers": [], "additional_components": [ "WBGene00000858", "Q9N532", "WBGene00003238", "G5EDV1", "WBGene00003006", "Q9N532", "WBGene00003238", "G5EDV1", "WBGene00003006", "P34889", "WBGene00000858" ] }, "reaction_10549919": { "compartment": "compartment_876", "id": "reaction_10549919", "reactome": "R-CEL-5138433", "name": "p-DVL2 recruits AP-2 and beta-arrestin 2 to promote clathrin-mediated endocytosis", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10521727", "species_10549913", "species_10549904" ], "products": [ "species_10549917" ], "modifiers": [], "additional_components": [ "WBGene00000195", "P34574", "WBGene00011867", "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q9N532", "WBGene00003238", "G5EDV1", "WBGene00003006", "P34889", "WBGene00000858", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "P34574", "WBGene00011867", "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q9N532", "WBGene00003238", "G5EDV1", "WBGene00003006", "P34889", "WBGene00000858", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "P51485", "WBGene00000195" ] }, "reaction_10549967": { "compartment": "compartment_20592", "id": "reaction_10549967", "reactome": "R-CEL-5138459", "name": "WNT5A:FZD4 is endocytosed", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10549917" ], "products": [ "species_10521727", "species_10549965" ], "modifiers": [], "additional_components": [ "P34574", "WBGene00011867", "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q9N532", "WBGene00003238", "G5EDV1", "WBGene00003006", "P34889", "WBGene00000858", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "P51485", "WBGene00000195", "WBGene00000195", "Q9N4F3", "WBGene00000160", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q22601", "WBGene00000161", "P34574", "WBGene00011867", "P34889", "WBGene00000858", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "G5EDV1", "WBGene00003006", "Q9N532", "WBGene00003238" ] }, "reaction_10548310": { "compartment": "compartment_876", "id": "reaction_10548310", "reactome": "R-CEL-3858482", "name": "DVL is recruited to the receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10548306", "species_10548304" ], "products": [ "species_10548308" ], "modifiers": [], "additional_components": [ "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "A0A0K3AWM6", "T23D8.1b", "Q27886", "WBGene00003029", "Q10459", "WBGene00003395", "A0A0K3AWM6", "T23D8.1b", "Q27886", "WBGene00003029", "Q10459", "WBGene00003395", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241" ] }, "reaction_10548294": { "compartment": "compartment_70101", "id": "reaction_10548294", "reactome": "R-CEL-3858475", "name": "ppDVL recruits RAC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10548290", "species_10548288" ], "products": [ "species_10548292" ], "modifiers": [], "additional_components": [ "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "Q03206", "ced-10", "species_29438", "Q03206", "ced-10", "species_29438", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241" ] }, "reaction_10549994": { "compartment": "compartment_20592", "id": "reaction_10549994", "reactome": "R-CEL-5140747", "name": "FZD2, FZD5 and ROR2 are internalized in a WNT5A and clathrin-dependent manner", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10549978" ], "products": [ "species_10549992" ], "modifiers": [ [ "species_10549913", "catalyst" ] ], "additional_components": [ "G5EGK5", "WBGene00000289", "A0A0K3AWM6", "T23D8.1b", "G5ECQ2", "WBGene00000478", "P34889", "WBGene00000858", "P34889", "WBGene00000858", "G5ECQ2", "WBGene00000478", "G5EGK5", "WBGene00000289", "A0A0K3AWM6", "T23D8.1b", "P34574", "WBGene00011867", "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "P35603", "WBGene00001082", "Q19123", "WBGene00000157" ] }, "reaction_10549980": { "compartment": "compartment_876", "id": "reaction_10549980", "reactome": "R-CEL-5140741", "name": "WNT5A binds FZD and ROR receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546954", "species_10549976" ], "products": [ "species_10549978" ], "modifiers": [], "additional_components": [ "WBGene00000858", "G5EGK5", "WBGene00000289", "A0A0K3AWM6", "T23D8.1b", "G5ECQ2", "WBGene00000478", "G5EGK5", "WBGene00000289", "A0A0K3AWM6", "T23D8.1b", "G5ECQ2", "WBGene00000478", "P34889", "WBGene00000858" ] }, "reaction_10549896": { "compartment": "compartment_876", "id": "reaction_10549896", "reactome": "R-CEL-5099886", "name": "WNT5A binding to FZD promotes PRICKLE1 degradation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546954", "species_10549892" ], "products": [ "species_10549894" ], "modifiers": [], "additional_components": [ "WBGene00000858", "G5ECQ2", "WBGene00000478", "G5ECQ2", "WBGene00000478", "P34889", "WBGene00000858" ] }, "reaction_10549370": { "compartment": "compartment_70101", "id": "reaction_10549370", "reactome": "R-CEL-4608855", "name": "PRICKLE1 is degraded by the proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10549368" ], "products": [], "modifiers": [ [ "species_10502572", "catalyst" ] ], "additional_components": [ "H2KYA1", "WBGene00022727", "H2KZA3", "WBGene00004112", "Q17525", "WBGene00015217", "P91477", "WBGene00003950", "Q95PZ7", "WBGene00013435", "Q18115", "WBGene00004459", "O62102", "WBGene00003948", "O17071", "WBGene00004504", "Q10920", "WBGene00016623", "P34286", "WBGene00003952", "Q9XTT9", "WBGene00004506", "Q23449", "WBGene00004468", "Q95005", "WBGene00003925", "P46502", "WBGene00004503", "O61792", "WBGene00004464", "O17586", "WBGene00003922", "O76371", "WBGene00004505", "Q20585", "WBGene00004463", "Q95008", "WBGene00003926", "Q18787", "WBGene00004501", "Q20058", "WBGene00009445", "Q9N599", "WBGene00003924", "O16368", "WBGene00004502", "O61742", "WBGene00004466", "Q09583", "WBGene00003928", "Q966I8", "WBGene00003947", "Q04908", "WBGene00004460", "Q9XUV0", "WBGene00003951", "Q27488", "WBGene00003923", "Q9GZH5", "WBGene00004458", "O44156", "WBGene00003927", "Q22253", "WBGene00004465", "O76577", "WBGene00004467", "P90868", "WBGene00003953", "Q19324", "WBGene00004461", "Q17971", "WBGene00007588", "Q23237", "WBGene00003949", "Q20938", "WBGene00004462" ] }, "reaction_10567373": { "compartment": "compartment_876", "id": "reaction_10567373", "reactome": "R-CEL-8875661", "name": "GGA3 associates with activated MET receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10565510", "species_10565557", "species_10567330" ], "products": [ "species_10567371" ], "modifiers": [], "additional_components": [ "WBGene00000166", "Q9U2S4", "WBGene00000184", "species_29438", "G5EDJ4", "WBGene00004928", "Q9XVQ7", "WBGene00008711", "P29355", "WBGene00004774", "Q9NHC3", "WBGene00000416", "Q95XA9", "WBGene00021238", "G5EDJ4", "WBGene00004928", "Q9XVQ7", "WBGene00008711", "P29355", "WBGene00004774", "Q9NHC3", "WBGene00000416", "Q95XA9", "WBGene00021238", "Q9U2S4", "WBGene00000184", "species_29438", "Q23165", "WBGene00000166" ] }, "reaction_10515028": { "compartment": "compartment_876", "id": "reaction_10515028", "reactome": "R-CEL-201677", "name": "Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10515006", "species_113592" ], "products": [ "species_29370", "species_10515025" ], "modifiers": [ [ "species_10515006", "catalyst" ] ], "additional_components": [ "A0A0K3AWM6", "T23D8.1b", "G5EBV9", "WBGene00020481", "Q22179", "WBGene00003075", "Q7JP80", "WBGene00020481", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "Q9U2Q9", "WBGene00001746", "Q09595", "WBGene00010991", "Q93372", "WBGene00010991", "O62090", "WBGene00004202", "A0A0K3AWM6", "T23D8.1b", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "Q9U2Q9", "WBGene00001746", "Q09595", "WBGene00010991", "Q93372", "WBGene00010991", "O62090", "WBGene00004202", "G5EBV9", "WBGene00020481", "Q22179", "WBGene00003075", "Q7JP80", "WBGene00020481", "A0A0K3AWM6", "T23D8.1b", "G5EBV9", "WBGene00020481", "Q22179", "WBGene00003075", "Q7JP80", "WBGene00020481", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "Q9U2Q9", "WBGene00001746", "Q09595", "WBGene00010991", "Q93372", "WBGene00010991", "O62090", "WBGene00004202" ] }, "reaction_10535159": { "compartment": "compartment_70101", "id": "reaction_10535159", "reactome": "R-CEL-1504186", "name": "DVL recruits GSK3beta:AXIN1 to the receptor complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10514942", "species_10515004" ], "products": [ "species_10515006" ], "modifiers": [], "additional_components": [ "Q9U2Q9", "WBGene00001746", "Q09595", "WBGene00010991", "Q93372", "WBGene00010991", "O62090", "WBGene00004202", "A0A0K3AWM6", "T23D8.1b", "G5EBV9", "WBGene00020481", "Q22179", "WBGene00003075", "Q7JP80", "WBGene00020481", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "A0A0K3AWM6", "T23D8.1b", "G5EBV9", "WBGene00020481", "Q22179", "WBGene00003075", "Q7JP80", "WBGene00020481", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "Q9U2Q9", "WBGene00001746", "Q09595", "WBGene00010991", "Q93372", "WBGene00010991", "O62090", "WBGene00004202" ] }, "reaction_10551830": { "compartment": "compartment_876", "id": "reaction_10551830", "reactome": "R-CEL-5368596", "name": "WNT3A stimulates the caveolin-dependent internalization of FZD5:p-LRP6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10551808" ], "products": [ "species_10551828" ], "modifiers": [], "additional_components": [ "G5ECQ2", "WBGene00000478", "Q18879", "WBGene00000302", "Q94051", "WBGene00000301", "Q9U2Q9", "WBGene00001746", "Q09595", "WBGene00010991", "Q93372", "WBGene00010991", "O62090", "WBGene00004202", "G5EBV9", "WBGene00020481", "Q22179", "WBGene00003075", "Q7JP80", "WBGene00020481", "Q7JP80", "WBGene00020481", "G5EBV9", "WBGene00020481", "Q22179", "WBGene00003075", "Q18879", "WBGene00000302", "Q94051", "WBGene00000301", "G5ECQ2", "WBGene00000478", "Q9U2Q9", "WBGene00001746", "Q09595", "WBGene00010991", "Q93372", "WBGene00010991", "O62090", "WBGene00004202" ] }, "reaction_10507606": { "compartment": "compartment_7660", "id": "reaction_10507606", "reactome": "R-CEL-75949", "name": "RNA Polymerase II Promoter Opening: First Transition", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10507432" ], "products": [ "species_113550", "species_113582", "species_10507424" ], "modifiers": [ [ "species_10506316", "catalyst" ] ], "additional_components": [ "G5EG49", "WBGene00013998", "G5EG47", "WBGene00010054", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q95ZS0", "WBGene00006392", "Q9GZI6", "WBGene00006387", "G5EF68", "WBGene00006386", "O45784", "WBGene00006391", "P32085", "WBGene00006542", "O61707", "WBGene00006385", "Q9NEW8", "WBGene00006389", "Q9TYN3", "WBGene00006383", "Q18265", "WBGene00016173", "Q17957", "WBGene00006397", "E9P861", "WBGene00006384", "Q20361", "WBGene00006395", "G5EGM3", "WBGene00006382", "O44625", "WBGene00004136", "Q9NEX2", "WBGene00013736", "O16991", "WBGene00006648", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "G5EG49", "WBGene00013998", "G5EG47", "WBGene00010054", "O44625", "WBGene00004136", "Q9NEX2", "WBGene00013736", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q95ZS0", "WBGene00006392", "Q9GZI6", "WBGene00006387", "G5EF68", "WBGene00006386", "O45784", "WBGene00006391", "P32085", "WBGene00006542", "O61707", "WBGene00006385", "Q9NEW8", "WBGene00006389", "Q9TYN3", "WBGene00006383", "Q18265", "WBGene00016173", "Q17957", "WBGene00006397", "E9P861", "WBGene00006384", "Q20361", "WBGene00006395", "G5EGM3", "WBGene00006382", "O16991", "WBGene00006648", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529" ] }, "reaction_10507459": { "compartment": "compartment_7660", "id": "reaction_10507459", "reactome": "R-CEL-75873", "name": "Addition of Nucleotides 5 through 9 on the growing Transcript", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30595", "species_10507442" ], "products": [ "species_113541", "species_10506516", "species_10506433", "species_10507457", "species_10506528" ], "modifiers": [ [ "species_10504433", "catalyst" ] ], "additional_components": [ "species_110614", "species_29358", "species_29494", "species_29438", "G5EG49", "WBGene00013998", "G5EG47", "WBGene00010054", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "O44625", "WBGene00004136", "Q9NEX2", "WBGene00013736", "Q95ZS0", "WBGene00006392", "Q9GZI6", "WBGene00006387", "G5EF68", "WBGene00006386", "O45784", "WBGene00006391", "P32085", "WBGene00006542", "O61707", "WBGene00006385", "Q9NEW8", "WBGene00006389", "Q9TYN3", "WBGene00006383", "Q18265", "WBGene00016173", "Q17957", "WBGene00006397", "E9P861", "WBGene00006384", "Q20361", "WBGene00006395", "G5EGM3", "WBGene00006382", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q95ZS0", "WBGene00006392", "Q9GZI6", "WBGene00006387", "G5EF68", "WBGene00006386", "O45784", "WBGene00006391", "P32085", "WBGene00006542", "O61707", "WBGene00006385", "Q9NEW8", "WBGene00006389", "Q9TYN3", "WBGene00006383", "Q18265", "WBGene00016173", "Q17957", "WBGene00006397", "E9P861", "WBGene00006384", "Q20361", "WBGene00006395", "G5EGM3", "WBGene00006382", "O44625", "WBGene00004136", "Q9NEX2", "WBGene00013736", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "G5EG49", "WBGene00013998", "G5EG47", "WBGene00010054", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140" ] }, "reaction_10507444": { "compartment": "compartment_7660", "id": "reaction_10507444", "reactome": "R-CEL-75869", "name": "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30595", "species_10507394" ], "products": [ "species_10506438", "species_113541", "species_10507442" ], "modifiers": [ [ "species_10504433", "catalyst" ] ], "additional_components": [ "species_110614", "species_29358", "species_29494", "species_29438", "G5EG49", "WBGene00013998", "G5EG47", "WBGene00010054", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "O44625", "WBGene00004136", "Q9NEX2", "WBGene00013736", "Q95ZS0", "WBGene00006392", "Q9GZI6", "WBGene00006387", "G5EF68", "WBGene00006386", "O45784", "WBGene00006391", "P32085", "WBGene00006542", "O61707", "WBGene00006385", "Q9NEW8", "WBGene00006389", "Q9TYN3", "WBGene00006383", "Q18265", "WBGene00016173", "Q17957", "WBGene00006397", "E9P861", "WBGene00006384", "Q20361", "WBGene00006395", "G5EGM3", "WBGene00006382", "O16991", "WBGene00006648", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "WBGene00006648", "G5EG49", "WBGene00013998", "G5EG47", "WBGene00010054", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "O44625", "WBGene00004136", "Q9NEX2", "WBGene00013736", "Q95ZS0", "WBGene00006392", "Q9GZI6", "WBGene00006387", "G5EF68", "WBGene00006386", "O45784", "WBGene00006391", "P32085", "WBGene00006542", "O61707", "WBGene00006385", "Q9NEW8", "WBGene00006389", "Q9TYN3", "WBGene00006383", "Q18265", "WBGene00016173", "Q17957", "WBGene00006397", "E9P861", "WBGene00006384", "Q20361", "WBGene00006395", "G5EGM3", "WBGene00006382", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140" ] }, "reaction_10508100": { "compartment": "compartment_7660", "id": "reaction_10508100", "reactome": "R-CEL-76576", "name": "Addition of nucleotides 10 and 11 on the growing transcript: Third Transition", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30595", "species_10507457" ], "products": [ "species_113541", "species_10508098" ], "modifiers": [ [ "species_10504433", "catalyst" ] ], "additional_components": [ "species_110614", "species_29358", "species_29494", "species_29438", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140" ] }, "reaction_10507397": { "compartment": "compartment_7660", "id": "reaction_10507397", "reactome": "R-CEL-75850", "name": "Addition of the third nucleotide on the nascent transcript", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30595", "species_10506530" ], "products": [ "species_113541", "species_10507394" ], "modifiers": [ [ "species_10504433", "catalyst" ] ], "additional_components": [ "species_110614", "species_29358", "species_29494", "species_29438", "G5EG49", "WBGene00013998", "G5EG47", "WBGene00010054", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "O44625", "WBGene00004136", "Q9NEX2", "WBGene00013736", "Q95ZS0", "WBGene00006392", "Q9GZI6", "WBGene00006387", "G5EF68", "WBGene00006386", "O45784", "WBGene00006391", "P32085", "WBGene00006542", "O61707", "WBGene00006385", "Q9NEW8", "WBGene00006389", "Q9TYN3", "WBGene00006383", "Q18265", "WBGene00016173", "Q17957", "WBGene00006397", "E9P861", "WBGene00006384", "Q20361", "WBGene00006395", "G5EGM3", "WBGene00006382", "O16991", "WBGene00006648", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "G5EG49", "WBGene00013998", "G5EG47", "WBGene00010054", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "O44625", "WBGene00004136", "Q9NEX2", "WBGene00013736", "Q95ZS0", "WBGene00006392", "Q9GZI6", "WBGene00006387", "G5EF68", "WBGene00006386", "O45784", "WBGene00006391", "P32085", "WBGene00006542", "O61707", "WBGene00006385", "Q9NEW8", "WBGene00006389", "Q9TYN3", "WBGene00006383", "Q18265", "WBGene00016173", "Q17957", "WBGene00006397", "E9P861", "WBGene00006384", "Q20361", "WBGene00006395", "G5EGM3", "WBGene00006382", "O16991", "WBGene00006648", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140" ] }, "reaction_10572134": { "compartment": "compartment_7660", "id": "reaction_10572134", "reactome": "R-CEL-9613494", "name": "Unwinding of DNA for the Nascent Transcript: Second Transition", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10507394" ], "products": [ "species_164121", "species_113541", "species_10507394" ], "modifiers": [ [ "species_10506316", "catalyst" ] ], "additional_components": [ "G5EG49", "WBGene00013998", "G5EG47", "WBGene00010054", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "O44625", "WBGene00004136", "Q9NEX2", "WBGene00013736", "Q95ZS0", "WBGene00006392", "Q9GZI6", "WBGene00006387", "G5EF68", "WBGene00006386", "O45784", "WBGene00006391", "P32085", "WBGene00006542", "O61707", "WBGene00006385", "Q9NEW8", "WBGene00006389", "Q9TYN3", "WBGene00006383", "Q18265", "WBGene00016173", "Q17957", "WBGene00006397", "E9P861", "WBGene00006384", "Q20361", "WBGene00006395", "G5EGM3", "WBGene00006382", "O16991", "WBGene00006648", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "G5EG49", "WBGene00013998", "G5EG47", "WBGene00010054", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "O44625", "WBGene00004136", "Q9NEX2", "WBGene00013736", "Q95ZS0", "WBGene00006392", "Q9GZI6", "WBGene00006387", "G5EF68", "WBGene00006386", "O45784", "WBGene00006391", "P32085", "WBGene00006542", "O61707", "WBGene00006385", "Q9NEW8", "WBGene00006389", "Q9TYN3", "WBGene00006383", "Q18265", "WBGene00016173", "Q17957", "WBGene00006397", "E9P861", "WBGene00006384", "Q20361", "WBGene00006395", "G5EGM3", "WBGene00006382", "O16991", "WBGene00006648", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529" ] }, "reaction_10572136": { "compartment": "compartment_7660", "id": "reaction_10572136", "reactome": "R-CEL-9613497", "name": "Unwinding DNA for the nascent transcript", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30595", "species_10506530" ], "products": [ "species_113541", "species_10506530" ], "modifiers": [ [ "species_10506316", "catalyst" ] ], "additional_components": [ "species_110614", "species_29358", "species_29494", "species_29438", "G5EG49", "WBGene00013998", "G5EG47", "WBGene00010054", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "O44625", "WBGene00004136", "Q9NEX2", "WBGene00013736", "Q95ZS0", "WBGene00006392", "Q9GZI6", "WBGene00006387", "G5EF68", "WBGene00006386", "O45784", "WBGene00006391", "P32085", "WBGene00006542", "O61707", "WBGene00006385", "Q9NEW8", "WBGene00006389", "Q9TYN3", "WBGene00006383", "Q18265", "WBGene00016173", "Q17957", "WBGene00006397", "E9P861", "WBGene00006384", "Q20361", "WBGene00006395", "G5EGM3", "WBGene00006382", "O16991", "WBGene00006648", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "G5EG49", "WBGene00013998", "G5EG47", "WBGene00010054", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "O44625", "WBGene00004136", "Q9NEX2", "WBGene00013736", "Q95ZS0", "WBGene00006392", "Q9GZI6", "WBGene00006387", "G5EF68", "WBGene00006386", "O45784", "WBGene00006391", "P32085", "WBGene00006542", "O61707", "WBGene00006385", "Q9NEW8", "WBGene00006389", "Q9TYN3", "WBGene00006383", "Q18265", "WBGene00016173", "Q17957", "WBGene00006397", "E9P861", "WBGene00006384", "Q20361", "WBGene00006395", "G5EGM3", "WBGene00006382", "O16991", "WBGene00006648", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529" ] }, "reaction_10508830": { "compartment": "compartment_7660", "id": "reaction_10508830", "reactome": "R-CEL-111264", "name": "Addition of nucleotides between position +11 and +30", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30595", "species_10508098" ], "products": [ "species_10508135", "species_113541" ], "modifiers": [ [ "species_10504433", "catalyst" ] ], "additional_components": [ "species_110614", "species_29358", "species_29494", "species_29438", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140" ] }, "reaction_10547360": { "compartment": "compartment_70101", "id": "reaction_10547360", "reactome": "R-CEL-3322016", "name": "GBE1 catalyzes branch formation in polyGlc-GYG2 complexed with GYS2-a", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10547348" ], "products": [ "species_10547358" ], "modifiers": [ [ "species_10547328", "catalyst" ] ], "additional_components": [ "Q9U2D9", "WBGene00001793", "species_114632", "G5ECZ5", "WBGene00011684", "H2KYQ5", "WBGene00006863", "O45819", "WBGene00012020", "Q9U2D9", "WBGene00001793", "species_114632", "H2KYQ5", "WBGene00006863", "O45819", "WBGene00012020", "G5ECZ5", "WBGene00011684", "WBGene00011409" ] }, "reaction_10547331": { "compartment": "compartment_70101", "id": "reaction_10547331", "reactome": "R-CEL-3322005", "name": "GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-a", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10547303" ], "products": [ "species_10547323" ], "modifiers": [ [ "species_10547328", "catalyst" ] ], "additional_components": [ "Q9U2D9", "WBGene00001793", "species_114632", "H2KYQ5", "WBGene00006863", "Q9U2D9", "WBGene00001793", "species_114632", "H2KYQ5", "WBGene00006863", "WBGene00011409" ] }, "reaction_10547369": { "compartment": "compartment_70101", "id": "reaction_10547369", "reactome": "R-CEL-3322019", "name": "Autoglucosylation of GYG2 complexed with GYS2-b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10547364", "species_29410" ], "products": [ "species_10547366", "species_110096" ], "modifiers": [ [ "species_10547364", "catalyst" ] ], "additional_components": [ "Q9U2D9", "WBGene00001793", "species_114632", "G5ECZ5", "WBGene00011684", "H2KYQ5", "WBGene00006863", "O45819", "WBGene00012020", "G5ECZ5", "WBGene00011684", "H2KYQ5", "WBGene00006863", "O45819", "WBGene00012020", "Q9U2D9", "WBGene00001793", "species_114632", "Q9U2D9", "WBGene00001793", "species_114632", "G5ECZ5", "WBGene00011684", "H2KYQ5", "WBGene00006863", "O45819", "WBGene00012020" ] }, "reaction_10502858": { "compartment": "compartment_70101", "id": "reaction_10502858", "reactome": "R-CEL-70272", "name": "PGM:Mg2+ isomerise G6P to G1P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30537" ], "products": [ "species_29548" ], "modifiers": [ [ "species_10502855", "catalyst" ] ], "additional_components": [ "species_114632", "O45934", "WBGene00012803" ] }, "reaction_10547306": { "compartment": "compartment_70101", "id": "reaction_10547306", "reactome": "R-CEL-3322001", "name": "GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10547301", "species_29410" ], "products": [ "species_10547303", "species_110096" ], "modifiers": [ [ "species_10547301", "catalyst" ] ], "additional_components": [ "Q9U2D9", "WBGene00001793", "H2KYQ5", "WBGene00006863", "species_114632", "Q9U2D9", "WBGene00001793", "species_114632", "H2KYQ5", "WBGene00006863", "Q9U2D9", "WBGene00001793", "H2KYQ5", "WBGene00006863", "species_114632" ] }, "reaction_10547374": { "compartment": "compartment_70101", "id": "reaction_10547374", "reactome": "R-CEL-3322025", "name": "Autoglucosylation of GYG1 complexed with GYS1-a", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10547371", "species_29410" ], "products": [ "species_10547301", "species_110096" ], "modifiers": [ [ "species_10547371", "catalyst" ] ], "additional_components": [ "Q9U2D9", "WBGene00001793", "species_114632", "H2KYQ5", "WBGene00006863", "Q9U2D9", "WBGene00001793", "H2KYQ5", "WBGene00006863", "species_114632", "Q9U2D9", "WBGene00001793", "species_114632", "H2KYQ5", "WBGene00006863" ] }, "reaction_10547379": { "compartment": "compartment_70101", "id": "reaction_10547379", "reactome": "R-CEL-3322041", "name": "Phosphorylated GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10547315", "species_29410" ], "products": [ "species_110096", "species_10547376" ], "modifiers": [ [ "species_10547315", "catalyst" ], [ "species_30537", "catalyst" ] ], "additional_components": [ "H2KYQ5", "WBGene00006863", "species_114632", "Q9U2D9", "WBGene00001793", "species_114632", "H2KYQ5", "WBGene00006863", "Q9U2D9", "WBGene00001793", "H2KYQ5", "WBGene00006863", "species_114632", "Q9U2D9", "WBGene00001793" ] }, "reaction_10547318": { "compartment": "compartment_70101", "id": "reaction_10547318", "reactome": "R-CEL-3322003", "name": "Autoglucosylation of GYG1 complexed with GYS1-b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29410", "species_10547313" ], "products": [ "species_10547315", "species_110096" ], "modifiers": [ [ "species_10547313", "catalyst" ] ], "additional_components": [ "species_114632", "H2KYQ5", "WBGene00006863", "Q9U2D9", "WBGene00001793", "H2KYQ5", "WBGene00006863", "species_114632", "Q9U2D9", "WBGene00001793", "species_114632", "H2KYQ5", "WBGene00006863", "Q9U2D9", "WBGene00001793" ] }, "reaction_10547351": { "compartment": "compartment_70101", "id": "reaction_10547351", "reactome": "R-CEL-3322009", "name": "GYS2 catalyzes the polyglucosylation of oligoGlc-GYG2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10547346", "species_29410" ], "products": [ "species_10547348", "species_110096" ], "modifiers": [ [ "species_10547346", "catalyst" ] ], "additional_components": [ "G5ECZ5", "WBGene00011684", "H2KYQ5", "WBGene00006863", "O45819", "WBGene00012020", "Q9U2D9", "WBGene00001793", "species_114632", "Q9U2D9", "WBGene00001793", "species_114632", "G5ECZ5", "WBGene00011684", "H2KYQ5", "WBGene00006863", "O45819", "WBGene00012020", "G5ECZ5", "WBGene00011684", "H2KYQ5", "WBGene00006863", "O45819", "WBGene00012020", "Q9U2D9", "WBGene00001793", "species_114632" ] }, "reaction_10547383": { "compartment": "compartment_70101", "id": "reaction_10547383", "reactome": "R-CEL-3322057", "name": "GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10547376" ], "products": [ "species_10547381" ], "modifiers": [ [ "species_10547328", "catalyst" ] ], "additional_components": [ "species_114632", "H2KYQ5", "WBGene00006863", "Q9U2D9", "WBGene00001793", "species_114632", "H2KYQ5", "WBGene00006863", "Q9U2D9", "WBGene00001793", "WBGene00011409" ] }, "reaction_10572378": { "compartment": "compartment_70101", "id": "reaction_10572378", "reactome": "R-CEL-9638125", "name": "PGM1:Mg2+ isomerises G1P to G6P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29548" ], "products": [ "species_30537" ], "modifiers": [ [ "species_10572375", "catalyst" ] ], "additional_components": [ "Q21742", "WBGene00019890", "species_114632" ] }, "reaction_10547356": { "compartment": "compartment_70101", "id": "reaction_10547356", "reactome": "R-CEL-3322014", "name": "Autoglucosylation of GYG2 complexed with GYS2-a", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10547353", "species_29410" ], "products": [ "species_10547346", "species_110096" ], "modifiers": [ [ "species_10547353", "catalyst" ] ], "additional_components": [ "Q9U2D9", "WBGene00001793", "species_114632", "G5ECZ5", "WBGene00011684", "H2KYQ5", "WBGene00006863", "O45819", "WBGene00012020", "G5ECZ5", "WBGene00011684", "H2KYQ5", "WBGene00006863", "O45819", "WBGene00012020", "Q9U2D9", "WBGene00001793", "species_114632", "Q9U2D9", "WBGene00001793", "species_114632", "G5ECZ5", "WBGene00011684", "H2KYQ5", "WBGene00006863", "O45819", "WBGene00012020" ] }, "reaction_10569064": { "compartment": "compartment_70101", "id": "reaction_10569064", "reactome": "R-CEL-8951850", "name": "TSPO:BZRAP1 transports CHOL from outer mitochondrial membrane to inner mitochondrial membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8951853" ], "products": [ "species_193156" ], "modifiers": [ [ "species_10569061", "catalyst" ] ], "additional_components": [ "C7FZU5", "WBGene00077771", "Q9N415", "WBGene00006513" ] }, "reaction_10513657": { "compartment": "compartment_70101", "id": "reaction_10513657", "reactome": "R-CEL-196060", "name": "Reduction of isocaproaldehyde to 4-methylpentan-1-ol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_196095", "species_70106", "species_29364" ], "products": [ "species_29366", "species_196066" ], "modifiers": [ [ "species_10513654", "catalyst" ] ], "additional_components": [ "WBGene00016985" ] }, "reaction_10556977": { "compartment": "compartment_70101", "id": "reaction_10556977", "reactome": "R-CEL-5693390", "name": "HSD17B11 dehydrogenates EST17b to E1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193132", "species_29366" ], "products": [ "species_70106", "species_193066", "species_29364" ], "modifiers": [ [ "species_10556974", "catalyst" ] ], "additional_components": [ "A5JYX5", "WBGene00000967", "O18030", "WBGene00000968", "Q19843", "WBGene00000992", "Q22392", "WBGene00000982" ] }, "reaction_10557699": { "compartment": "compartment_5460", "id": "reaction_10557699", "reactome": "R-CEL-5696822", "name": "AKR1B15 reduces EST17b to E1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113563", "species_5696835" ], "products": [ "species_113529", "species_5696848", "species_113600" ], "modifiers": [ [ "species_10557696", "catalyst" ] ], "additional_components": [ "P91020", "WBGene00016985", "Q18903", "WBGene00016985", "Q23320", "WBGene00016985" ] }, "reaction_10513367": { "compartment": "compartment_70101", "id": "reaction_10513367", "reactome": "R-CEL-193143", "name": "CYP19A1 hydroxylates TEST to EST17b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29368", "species_29364", "species_193057" ], "products": [ "species_193132", "species_29356", "species_29366", "species_29460" ], "modifiers": [ [ "species_10513352", "catalyst" ] ], "additional_components": [ "Q09660", "WBGene00000375", "Q9N525", "WBGene00021412", "Q9N574", "WBGene00021200", "Q9XVA6", "WBGene00008499", "G5EC97", "WBGene00011830", "G5EGT6", "WBGene00010354", "O17851", "WBGene00009226", "O45219", "WBGene00007140" ] }, "reaction_10565899": { "compartment": "compartment_70101", "id": "reaction_10565899", "reactome": "R-CEL-8862137", "name": "HSD17B2 oxidises estradiol (E2) to estrone (E1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_176619", "species_29366" ], "products": [ "species_70106", "species_193066", "species_29364" ], "modifiers": [ [ "species_10565896", "catalyst" ] ], "additional_components": [ "O01758", "WBGene00000966", "O16881", "WBGene00000979", "Q20012", "WBGene00000983", "Q20840", "WBGene00018885" ] }, "reaction_10533200": { "compartment": "compartment_984", "id": "reaction_10533200", "reactome": "R-CEL-1449687", "name": "Corticosteroids bind to CBG in blood", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1449707", "species_10533196" ], "products": [ "species_10533198" ], "modifiers": [], "additional_components": [ "CHEBI:27584", "CHEBI:17026", "species_193977", "CHEBI:16973", "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "A9Z1L1", "WBGene00005648", "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "A9Z1L1", "WBGene00005648", "CHEBI:27584", "CHEBI:17026", "species_193977", "CHEBI:16973" ] }, "reaction_10513471": { "compartment": "compartment_17957", "id": "reaction_10513471", "reactome": "R-CEL-194023", "name": "HSD11B2,HSD11B1 dimer oxidise CORT to COR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193977", "species_29366" ], "products": [ "species_70106", "species_29364", "species_194035" ], "modifiers": [ [ "species_10513468", "catalyst" ] ], "additional_components": [ "O16881", "WBGene00000979", "Q20012", "WBGene00000983", "Q20840", "WBGene00018885", "O01758", "WBGene00000966" ] }, "reaction_10573281": { "compartment": "compartment_70101", "id": "reaction_10573281", "reactome": "R-CEL-9705713", "name": "SRD5A2 dehydrogenates TEST to DHTEST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_193057" ], "products": [ "species_469662", "species_29366" ], "modifiers": [ [ "species_10573278", "catalyst" ] ], "additional_components": [ "Q19605", "WBGene00014241", "Q20344", "WBGene00009635", "Q23431", "WBGene00014241" ] }, "reaction_10513365": { "compartment": "compartment_70101", "id": "reaction_10513365", "reactome": "R-CEL-193064", "name": "HSD17B3-like proteins reducde ANDST to TEST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_193079", "species_29364" ], "products": [ "species_29366", "species_193057" ], "modifiers": [ [ "species_10513360", "catalyst" ] ], "additional_components": [ "WBGene00000969" ] }, "reaction_10573284": { "compartment": "compartment_70101", "id": "reaction_10573284", "reactome": "R-CEL-9705714", "name": "SRD5A3 dehydrogenates TEST to DHTEST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_193057" ], "products": [ "species_469662", "species_29366" ], "modifiers": [ [ "species_10549201", "catalyst" ] ], "additional_components": [ "WBGene00007102" ] }, "reaction_10526217": { "compartment": "compartment_70101", "id": "reaction_10526217", "reactome": "R-CEL-469659", "name": "SRD5A1 dehydrogenates TEST to DHTEST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_193057" ], "products": [ "species_469662", "species_29366" ], "modifiers": [ [ "species_10526214", "catalyst" ] ], "additional_components": [ "WBGene00009635" ] }, "reaction_10567315": { "compartment": "compartment_70101", "id": "reaction_10567315", "reactome": "R-CEL-8875451", "name": "MET phosphorylates CBL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10567312" ], "products": [ "species_29370", "species_10567233" ], "modifiers": [ [ "species_10567312", "catalyst" ] ], "additional_components": [ "Q9XVQ7", "WBGene00008711", "P29355", "WBGene00004774", "Q19019", "WBGene00004829", "Q9XVQ7", "WBGene00008711", "P29355", "WBGene00004774", "Q19019", "WBGene00004829", "Q9XVQ7", "WBGene00008711", "P29355", "WBGene00004774", "Q19019", "WBGene00004829" ] }, "reaction_10567305": { "compartment": "compartment_876", "id": "reaction_10567305", "reactome": "R-CEL-8875374", "name": "MET binds LRIG1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10521542", "species_10567301" ], "products": [ "species_10567303" ], "modifiers": [], "additional_components": [ "WBGene00008711", "WBGene00020649", "Q965M2", "WBGene00020649", "Q9XVQ7", "WBGene00008711" ] }, "reaction_10567321": { "compartment": "compartment_70101", "id": "reaction_10567321", "reactome": "R-CEL-8875490", "name": "EPS15 and HGS bind ubiquitinated MET", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10512223", "species_10567317" ], "products": [ "species_10567319" ], "modifiers": [], "additional_components": [ "Q9BIF4", "WBGene00001224", "Q17796", "WBGene00004101", "O01498", "WBGene00004109", "Q9BIF4", "WBGene00001224", "Q17796", "WBGene00004101", "O01498", "WBGene00004109" ] }, "reaction_10567245": { "compartment": "compartment_70101", "id": "reaction_10567245", "reactome": "R-CEL-8875183", "name": "CBL monoubiquitinates activated MET", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502375", "species_10567233" ], "products": [ "species_10567242" ], "modifiers": [ [ "species_10567233", "catalyst" ] ], "additional_components": [ "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "Q9XVQ7", "WBGene00008711", "P29355", "WBGene00004774", "Q19019", "WBGene00004829", "Q9XVQ7", "WBGene00008711", "P29355", "WBGene00004774", "Q19019", "WBGene00004829", "Q9XVQ7", "WBGene00008711", "P29355", "WBGene00004774", "Q19019", "WBGene00004829" ] }, "reaction_10508741": { "compartment": "compartment_7660", "id": "reaction_10508741", "reactome": "R-CEL-110308", "name": "REV1 inserts dCMP opposite to AP sites in DNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508730", "species_30185" ], "products": [ "species_10508738" ], "modifiers": [ [ "species_10508730", "catalyst" ] ], "additional_components": [ "Q95Y97", "WBGene00019767", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "O02115", "WBGene00003955", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "Q09615", "WBGene00014066", "Q95Y97", "WBGene00019767", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "O02115", "WBGene00003955", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "Q09615", "WBGene00014066", "Q95Y97", "WBGene00019767", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "O02115", "WBGene00003955", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "Q09615", "WBGene00014066" ] }, "reaction_10508732": { "compartment": "compartment_7660", "id": "reaction_10508732", "reactome": "R-CEL-110307", "name": "REV1 binds AP-dsDNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508715", "species_10508728" ], "products": [ "species_10508730" ], "modifiers": [], "additional_components": [ "WBGene00014066", "Q95Y97", "WBGene00019767", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "O02115", "WBGene00003955", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "Q95Y97", "WBGene00019767", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "O02115", "WBGene00003955", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "Q09615", "WBGene00014066" ] }, "reaction_10567136": { "compartment": "compartment_70101", "id": "reaction_10567136", "reactome": "R-CEL-8873850", "name": "STARD5 binds DCA, LCA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_176655", "species_10567132", "species_5357505" ], "products": [ "species_10567134" ], "modifiers": [], "additional_components": [ "WBGene00010505", "species_5357505", "Q21130", "WBGene00010505", "species_176655" ] }, "reaction_10510001": { "compartment": "compartment_70101", "id": "reaction_10510001", "reactome": "R-CEL-159425", "name": "Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_76194", "species_194096" ], "products": [ "species_111294", "species_29356", "species_194073", "species_76577" ], "modifiers": [ [ "species_10509998", "catalyst" ] ], "additional_components": [ "species_193451", "CHEBI:16755", "species_192356", "species_193472", "Q18916", "WBGene00017012", "Q19878", "WBGene00009218" ] }, "reaction_10513491": { "compartment": "compartment_876", "id": "reaction_10513491", "reactome": "R-CEL-194187", "name": "SLC10A2 transports bile salts and acids and Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10513481", "species_192483", "species_74113" ], "products": [ "species_10513483", "species_83910" ], "modifiers": [ [ "species_10513488", "catalyst" ] ], "additional_components": [ "O01812", "WBGene00002258", "O01814", "WBGene00002257", "O02323", "WBGene00002259", "O02324", "WBGene00002260", "CHEBI:17687", "CHEBI:28865", "CHEBI:16755", "CHEBI:36274", "species_193451", "CHEBI:9407", "O01812", "WBGene00002258", "O01814", "WBGene00002257", "O02323", "WBGene00002259", "O02324", "WBGene00002260", "species_193451", "CHEBI:17687", "CHEBI:36274", "CHEBI:16525", "CHEBI:16755", "CHEBI:28865", "WBGene00044650" ] }, "reaction_10551492": { "compartment": "compartment_7660", "id": "reaction_10551492", "reactome": "R-CEL-5340195", "name": "NR1H4 binds DCA, CDCA, LCHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5340249", "species_10519476" ], "products": [ "species_10551490" ], "modifiers": [], "additional_components": [ "species_176655", "CHEBI:16755", "species_5357505", "WBGene00006790", "G5ECR9", "WBGene00006790", "species_176655", "CHEBI:16755", "species_5357505" ] }, "reaction_10513382": { "compartment": "compartment_876", "id": "reaction_10513382", "reactome": "R-CEL-193362", "name": "ABCB11 transports bile salts from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_193416", "species_113592" ], "products": [ "species_29372", "species_29370", "species_193479" ], "modifiers": [ [ "species_10513379", "catalyst" ] ], "additional_components": [ "CHEBI:17687", "CHEBI:36274", "CHEBI:16525", "CHEBI:28865", "CHEBI:17687", "CHEBI:28865", "CHEBI:36274", "CHEBI:9407", "P34712", "WBGene00003995", "G5EG58", "WBGene00004003" ] }, "reaction_10510026": { "compartment": "compartment_70101", "id": "reaction_10510026", "reactome": "R-CEL-159431", "name": "Cytosolic chenodeoxycholoyl-CoA or choloyl-CoA are conjugated with glycine or taurine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_194073", "species_194069" ], "products": [ "species_193416", "species_76194" ], "modifiers": [ [ "species_10510023", "catalyst" ] ], "additional_components": [ "species_192356", "species_193472", "species_159549", "CHEBI:15891", "CHEBI:17687", "CHEBI:36274", "CHEBI:16525", "CHEBI:28865", "O45003", "WBGene00020989", "Q9GYN3", "WBGene00020989", "B3WFZ3", "WBGene00020989", "O01862", "WBGene00020989" ] }, "reaction_10513424": { "compartment": "compartment_17951", "id": "reaction_10513424", "reactome": "R-CEL-193736", "name": "Isomerization of 3,7,24THCA-CoA to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193732" ], "products": [ "species_193732" ], "modifiers": [ [ "species_10513241", "catalyst" ] ], "additional_components": [ "WBGene00016034" ] }, "reaction_10513426": { "compartment": "compartment_70101", "id": "reaction_10513426", "reactome": "R-CEL-193743", "name": "3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_76194", "species_193778" ], "products": [ "species_111294", "species_29356", "species_193739", "species_76577" ], "modifiers": [ [ "species_10513398", "catalyst" ] ], "additional_components": [ "Q18916", "WBGene00017012", "Q19878", "WBGene00009218" ] }, "reaction_10513428": { "compartment": "compartment_70101", "id": "reaction_10513428", "reactome": "R-CEL-193746", "name": "4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193724", "species_70106", "species_29364" ], "products": [ "species_29366", "species_193760" ], "modifiers": [ [ "species_10513222", "catalyst" ] ], "additional_components": [ "Q23320", "WBGene00016985", "P91020", "WBGene00016985", "Q18903", "WBGene00016985" ] }, "reaction_10513430": { "compartment": "compartment_70101", "id": "reaction_10513430", "reactome": "R-CEL-193755", "name": "4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_193745" ], "products": [ "species_193707", "species_29366" ], "modifiers": [ [ "species_10513222", "catalyst" ] ], "additional_components": [ "Q23320", "WBGene00016985", "P91020", "WBGene00016985", "Q18903", "WBGene00016985" ] }, "reaction_10513432": { "compartment": "compartment_70101", "id": "reaction_10513432", "reactome": "R-CEL-193758", "name": "5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_193760" ], "products": [ "species_29366", "species_213285" ], "modifiers": [ [ "species_10513233", "catalyst" ] ], "additional_components": [ "P91020", "WBGene00016985", "Q18903", "WBGene00016985", "Q23320", "WBGene00016985" ] }, "reaction_10513434": { "compartment": "compartment_17951", "id": "reaction_10513434", "reactome": "R-CEL-193763", "name": "Isomerization of 25(R) TetraHCA-CoA to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193793" ], "products": [ "species_193422" ], "modifiers": [ [ "species_10513241", "catalyst" ] ], "additional_components": [ "WBGene00016034" ] }, "reaction_10513436": { "compartment": "compartment_70101", "id": "reaction_10513436", "reactome": "R-CEL-193766", "name": "TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_76194", "species_193762" ], "products": [ "species_111294", "species_193741", "species_29356", "species_76577" ], "modifiers": [ [ "species_10509998", "catalyst" ] ], "additional_components": [ "Q18916", "WBGene00017012", "Q19878", "WBGene00009218" ] }, "reaction_10513420": { "compartment": "compartment_70101", "id": "reaction_10513420", "reactome": "R-CEL-193711", "name": "3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_76194", "species_193778" ], "products": [ "species_111294", "species_29356", "species_193739", "species_76577" ], "modifiers": [ [ "species_10509998", "catalyst" ] ], "additional_components": [ "Q18916", "WBGene00017012", "Q19878", "WBGene00009218" ] }, "reaction_10513438": { "compartment": "compartment_70101", "id": "reaction_10513438", "reactome": "R-CEL-193781", "name": "5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_193707", "species_29364" ], "products": [ "species_29366", "species_193728" ], "modifiers": [ [ "species_10513233", "catalyst" ] ], "additional_components": [ "P91020", "WBGene00016985", "Q18903", "WBGene00016985", "Q23320", "WBGene00016985" ] }, "reaction_10513422": { "compartment": "compartment_70101", "id": "reaction_10513422", "reactome": "R-CEL-193727", "name": "TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_76194", "species_193762" ], "products": [ "species_111294", "species_193741", "species_29356", "species_76577" ], "modifiers": [ [ "species_10513398", "catalyst" ] ], "additional_components": [ "Q18916", "WBGene00017012", "Q19878", "WBGene00009218" ] }, "reaction_10513440": { "compartment": "compartment_70101", "id": "reaction_10513440", "reactome": "R-CEL-193800", "name": "5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_193829", "species_29364" ], "products": [ "species_29366", "species_193843" ], "modifiers": [ [ "species_10513233", "catalyst" ] ], "additional_components": [ "P91020", "WBGene00016985", "Q18903", "WBGene00016985", "Q23320", "WBGene00016985" ] }, "reaction_10513442": { "compartment": "compartment_70101", "id": "reaction_10513442", "reactome": "R-CEL-193821", "name": "4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_9617026" ], "products": [ "species_193829", "species_29366" ], "modifiers": [ [ "species_10513222", "catalyst" ] ], "additional_components": [ "Q23320", "WBGene00016985", "P91020", "WBGene00016985", "Q18903", "WBGene00016985" ] }, "reaction_10513444": { "compartment": "compartment_70101", "id": "reaction_10513444", "reactome": "R-CEL-193824", "name": "4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_193835", "species_29364" ], "products": [ "species_29366", "species_193830" ], "modifiers": [ [ "species_10513222", "catalyst" ] ], "additional_components": [ "Q23320", "WBGene00016985", "P91020", "WBGene00016985", "Q18903", "WBGene00016985" ] }, "reaction_10513446": { "compartment": "compartment_70101", "id": "reaction_10513446", "reactome": "R-CEL-193841", "name": "5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_193830" ], "products": [ "species_29366", "species_193842" ], "modifiers": [ [ "species_10513233", "catalyst" ] ], "additional_components": [ "P91020", "WBGene00016985", "Q18903", "WBGene00016985", "Q23320", "WBGene00016985" ] }, "reaction_10513205": { "compartment": "compartment_70101", "id": "reaction_10513205", "reactome": "R-CEL-191983", "name": "Cholesterol is hydroxylated to 25-hydroxycholesterol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_176478", "species_70106", "species_29368", "species_29364" ], "products": [ "species_29356", "species_192148", "species_29366" ], "modifiers": [ [ "species_10513202", "catalyst" ] ], "additional_components": [ "Q20027", "WBGene00018036", "species_113531" ] }, "reaction_10566516": { "compartment": "compartment_70101", "id": "reaction_10566516", "reactome": "R-CEL-8868402", "name": "OSBP exchanges 25OH-CHOL with PI4P from ER membrane to Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8868399", "species_1806217" ], "products": [ "species_8868393", "species_1806234" ], "modifiers": [ [ "species_10566513", "catalyst" ] ], "additional_components": [ "WBGene00012930" ] }, "reaction_10566397": { "compartment": "compartment_70101", "id": "reaction_10566397", "reactome": "R-CEL-8867667", "name": "OSBPs transport 25OH-CHOL from ER membrane to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8868399" ], "products": [ "species_8868400" ], "modifiers": [ [ "species_10566394", "catalyst" ] ], "additional_components": [ "Q93485", "WBGene00008832", "O01686", "WBGene00016331" ] }, "reaction_10513248": { "compartment": "compartment_70101", "id": "reaction_10513248", "reactome": "R-CEL-192137", "name": "THCA is conjugated with Coenzyme A (SLC27A5 BACS)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_192013", "species_113592", "species_76194" ], "products": [ "species_111294", "species_192096", "species_76577" ], "modifiers": [ [ "species_10509998", "catalyst" ] ], "additional_components": [ "Q18916", "WBGene00017012", "Q19878", "WBGene00009218" ] }, "reaction_10513250": { "compartment": "compartment_70101", "id": "reaction_10513250", "reactome": "R-CEL-192160", "name": "5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191980", "species_70106", "species_29364" ], "products": [ "species_192030", "species_29366" ], "modifiers": [ [ "species_10513233", "catalyst" ] ], "additional_components": [ "P91020", "WBGene00016985", "Q18903", "WBGene00016985", "Q23320", "WBGene00016985" ] }, "reaction_10513410": { "compartment": "compartment_17951", "id": "reaction_10513410", "reactome": "R-CEL-193455", "name": "(24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193422", "species_192307" ], "products": [ "species_193465", "species_192305", "species_192339" ], "modifiers": [ [ "species_10513270", "catalyst" ] ], "additional_components": [ "Q19058", "WBGene00017123" ] }, "reaction_10513412": { "compartment": "compartment_17951", "id": "reaction_10513412", "reactome": "R-CEL-193491", "name": "Chenodeoxycholoyl CoA reacts with glycine or taurine to form glycochenodeoxycholate or taurochenodeoxycholate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193463", "species_193472" ], "products": [ "species_193453", "species_193514" ], "modifiers": [ [ "species_10513260", "catalyst" ] ], "additional_components": [ "species_159549", "CHEBI:15891", "CHEBI:36274", "CHEBI:16525", "B3WFZ3", "WBGene00020989", "O01862", "WBGene00020989", "O45003", "WBGene00020989", "Q9GYN3", "WBGene00020989" ] }, "reaction_10513414": { "compartment": "compartment_17951", "id": "reaction_10513414", "reactome": "R-CEL-193508", "name": "(24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193732", "species_192307" ], "products": [ "species_193465", "species_193403", "species_192305" ], "modifiers": [ [ "species_10513270", "catalyst" ] ], "additional_components": [ "Q19058", "WBGene00017123" ] }, "reaction_10513384": { "compartment": "compartment_17951", "id": "reaction_10513384", "reactome": "R-CEL-193369", "name": "25(S) DHCA-CoA is dehydrogenated to 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113535", "species_193442" ], "products": [ "species_113575", "species_193459" ], "modifiers": [ [ "species_10513307", "catalyst" ] ], "additional_components": [ "species_113596", "P34355", "WBGene00008167", "O62138", "WBGene00008566", "Q93839", "WBGene00010336", "O62139", "WBGene00008567", "O62140", "WBGene00008564", "O62137", "WBGene00008565" ] }, "reaction_10513416": { "compartment": "compartment_17951", "id": "reaction_10513416", "reactome": "R-CEL-193535", "name": "25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA is hydrated to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_141343", "species_193459" ], "products": [ "species_193732" ], "modifiers": [ [ "species_10513270", "catalyst" ] ], "additional_components": [ "Q19058", "WBGene00017123" ] }, "reaction_10513225": { "compartment": "compartment_70101", "id": "reaction_10513225", "reactome": "R-CEL-192033", "name": "4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_192136", "species_29364" ], "products": [ "species_191980", "species_29366" ], "modifiers": [ [ "species_10513222", "catalyst" ] ], "additional_components": [ "Q23320", "WBGene00016985", "P91020", "WBGene00016985", "Q18903", "WBGene00016985" ] }, "reaction_10513263": { "compartment": "compartment_17951", "id": "reaction_10513263", "reactome": "R-CEL-192312", "name": "Choloyl CoA reacts with glycine or taurine to form glycocholate or taurocholate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_192356", "species_193463" ], "products": [ "species_193404", "species_193514" ], "modifiers": [ [ "species_10513260", "catalyst" ] ], "additional_components": [ "species_159549", "CHEBI:15891", "CHEBI:17687", "CHEBI:28865", "B3WFZ3", "WBGene00020989", "O01862", "WBGene00020989", "O45003", "WBGene00020989", "Q9GYN3", "WBGene00020989" ] }, "reaction_10513392": { "compartment": "compartment_17951", "id": "reaction_10513392", "reactome": "R-CEL-193385", "name": "Hydrolysis of choloyl-CoA to cholate and CoASH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_141343", "species_192356" ], "products": [ "species_193451", "species_193514" ], "modifiers": [ [ "species_10513389", "catalyst" ] ], "additional_components": [ "WBGene00015887" ] }, "reaction_10513236": { "compartment": "compartment_70101", "id": "reaction_10513236", "reactome": "R-CEL-192036", "name": "5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_192064" ], "products": [ "species_29366", "species_192087" ], "modifiers": [ [ "species_10513233", "catalyst" ] ], "additional_components": [ "P91020", "WBGene00016985", "Q18903", "WBGene00016985", "Q23320", "WBGene00016985" ] }, "reaction_10513401": { "compartment": "compartment_70101", "id": "reaction_10513401", "reactome": "R-CEL-193401", "name": "THCA is conjugated with Coenzyme A (SLC27A2 VLCS)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_192013", "species_113592", "species_76194" ], "products": [ "species_111294", "species_192096", "species_76577" ], "modifiers": [ [ "species_10513398", "catalyst" ] ], "additional_components": [ "Q18916", "WBGene00017012", "Q19878", "WBGene00009218" ] }, "reaction_10513273": { "compartment": "compartment_17951", "id": "reaction_10513273", "reactome": "R-CEL-192331", "name": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) is hydrated to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_141343", "species_192342" ], "products": [ "species_193422" ], "modifiers": [ [ "species_10513270", "catalyst" ] ], "additional_components": [ "Q19058", "WBGene00017123" ] }, "reaction_10513403": { "compartment": "compartment_70101", "id": "reaction_10513403", "reactome": "R-CEL-193407", "name": "DHCA is conjugated with Coenzyme A (SLC27A5 BACS)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_193505", "species_76194" ], "products": [ "species_111294", "species_193457", "species_76577" ], "modifiers": [ [ "species_10509998", "catalyst" ] ], "additional_components": [ "Q18916", "WBGene00017012", "Q19878", "WBGene00009218" ] }, "reaction_10513244": { "compartment": "compartment_17951", "id": "reaction_10513244", "reactome": "R-CEL-192056", "name": "Isomerization of 25(R) THCA-CoA to 25(S) THCA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_192308" ], "products": [ "species_192316" ], "modifiers": [ [ "species_10513241", "catalyst" ] ], "additional_components": [ "WBGene00016034" ] }, "reaction_10513405": { "compartment": "compartment_70101", "id": "reaction_10513405", "reactome": "R-CEL-193424", "name": "DHCA is conjugated with Coenzyme A (SLC27A2 VLCS)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_76194", "species_193505" ], "products": [ "species_111294", "species_193457", "species_76577" ], "modifiers": [ [ "species_10513398", "catalyst" ] ], "additional_components": [ "Q18916", "WBGene00017012", "Q19878", "WBGene00009218" ] }, "reaction_10513246": { "compartment": "compartment_70101", "id": "reaction_10513246", "reactome": "R-CEL-192067", "name": "4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_192195" ], "products": [ "species_29366", "species_192064" ], "modifiers": [ [ "species_10513222", "catalyst" ] ], "additional_components": [ "Q23320", "WBGene00016985", "P91020", "WBGene00016985", "Q18903", "WBGene00016985" ] }, "reaction_10513310": { "compartment": "compartment_17951", "id": "reaction_10513310", "reactome": "R-CEL-192335", "name": "25(S) THCA-CoA is dehydrogenated to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113535", "species_192316" ], "products": [ "species_113575", "species_192342" ], "modifiers": [ [ "species_10513307", "catalyst" ] ], "additional_components": [ "species_113596", "P34355", "WBGene00008167", "O62138", "WBGene00008566", "Q93839", "WBGene00010336", "O62139", "WBGene00008567", "O62140", "WBGene00008564", "O62137", "WBGene00008565" ] }, "reaction_10513407": { "compartment": "compartment_17951", "id": "reaction_10513407", "reactome": "R-CEL-193452", "name": "Isomerization of 25(R) DHCA-CoA to 25(S) DHCA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193429" ], "products": [ "species_193442" ], "modifiers": [ [ "species_10513241", "catalyst" ] ], "additional_components": [ "WBGene00016034" ] }, "reaction_10516904": { "compartment": "compartment_13231", "id": "reaction_10516904", "reactome": "R-CEL-211219", "name": "Translocation of caspase-3 to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509422" ], "products": [ "species_10516902" ], "modifiers": [], "additional_components": [ "P42573", "WBGene00000417", "P42573", "WBGene00000417" ] }, "reaction_10517886": { "compartment": "compartment_7660", "id": "reaction_10517886", "reactome": "R-CEL-266204", "name": "Association of HMGB1/HMGB2 with chromatin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10517882", "species_29428" ], "products": [ "species_10517884" ], "modifiers": [], "additional_components": [ "Q09390", "WBGene00001972", "G5EFV4", "WBGene00001971", "Q09390", "WBGene00001972", "G5EFV4", "WBGene00001971" ] }, "reaction_10551440": { "compartment": "compartment_7660", "id": "reaction_10551440", "reactome": "R-CEL-5334854", "name": "RAR:RXR binds SUMO-CRABP2:atRA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10551436", "species_10551432" ], "products": [ "species_10551438" ], "modifiers": [], "additional_components": [ "species_5334816", "O01812", "WBGene00002258", "Q9U2R6", "WBGene00003681", "Q20765", "WBGene00003606", "P41830", "WBGene00004786", "Q9XUK7", "WBGene00003675", "Q10902", "WBGene00003601", "Q9U2R6", "WBGene00003681", "Q20765", "WBGene00003606", "P41830", "WBGene00004786", "Q9XUK7", "WBGene00003675", "Q10902", "WBGene00003601", "species_5334816", "O01812", "WBGene00002258" ] }, "reaction_10553123": { "compartment": "compartment_70101", "id": "reaction_10553123", "reactome": "R-CEL-5622129", "name": "FABP5 binds atRA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10551364", "species_5334816" ], "products": [ "species_10553121" ], "modifiers": [], "additional_components": [ "WBGene00021486", "species_5334816", "Q965W1", "WBGene00021486" ] }, "reaction_10552339": { "compartment": "compartment_7660", "id": "reaction_10552339", "reactome": "R-CEL-5422942", "name": "RXRA:PPARD binds FABP5:atRA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10552335", "species_10514501" ], "products": [ "species_10552337" ], "modifiers": [], "additional_components": [ "species_5334816", "Q965W1", "WBGene00021486", "Q9XUK7", "WBGene00003675", "P41830", "WBGene00004786", "Q10902", "WBGene00003601", "Q20765", "WBGene00003606", "Q9U2R6", "WBGene00003681", "Q9XUK7", "WBGene00003675", "P41830", "WBGene00004786", "Q10902", "WBGene00003601", "Q20765", "WBGene00003606", "Q9U2R6", "WBGene00003681", "species_5334816", "Q965W1", "WBGene00021486" ] }, "reaction_10552705": { "compartment": "compartment_70101", "id": "reaction_10552705", "reactome": "R-CEL-5615668", "name": "AKR1C3 reduces atRAL to atROL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_975622", "species_29364" ], "products": [ "species_29366", "species_975599" ], "modifiers": [ [ "species_10513233", "catalyst" ] ], "additional_components": [ "P91020", "WBGene00016985", "Q18903", "WBGene00016985", "Q23320", "WBGene00016985" ] }, "reaction_10551747": { "compartment": "compartment_70101", "id": "reaction_10551747", "reactome": "R-CEL-5362518", "name": "RDH10,16,DHRS9,RDHE2 oxidise atROL to atRAL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_975599", "species_29360" ], "products": [ "species_70106", "species_975622", "species_73473" ], "modifiers": [ [ "species_10551744", "catalyst" ] ], "additional_components": [ "A5JYX5", "WBGene00000967", "O18030", "WBGene00000968", "Q19843", "WBGene00000992", "Q22392", "WBGene00000982", "O16881", "WBGene00000979", "O01758", "WBGene00000966", "Q20012", "WBGene00000983", "Q20840", "WBGene00018885" ] }, "reaction_10553251": { "compartment": "compartment_70616", "id": "reaction_10553251", "reactome": "R-CEL-5623643", "name": "RDH13 reduces atRAL to atROL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5623644", "species_5623648", "species_163953" ], "products": [ "species_5623650", "species_5623649" ], "modifiers": [ [ "species_10553248", "catalyst" ] ], "additional_components": [ "WBGene00000985" ] }, "reaction_10551781": { "compartment": "compartment_70101", "id": "reaction_10551781", "reactome": "R-CEL-5362721", "name": "RDH5,RDH11 oxidise 11cROL to 11cRAL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30927", "species_29360" ], "products": [ "species_70106", "species_32737", "species_73473" ], "modifiers": [ [ "species_10551778", "catalyst" ] ], "additional_components": [ "Q20840", "WBGene00018885", "O01758", "WBGene00000966", "O16881", "WBGene00000979", "Q20012", "WBGene00000983" ] }, "reaction_10553125": { "compartment": "compartment_70101", "id": "reaction_10553125", "reactome": "R-CEL-5622134", "name": "CRABP1 binds atRA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5334816", "species_10551761" ], "products": [ "species_10551763" ], "modifiers": [], "additional_components": [ "O01812", "WBGene00002258", "O01814", "WBGene00002257", "O02323", "WBGene00002259", "O02324", "WBGene00002260", "O01812", "WBGene00002258", "O01814", "WBGene00002257", "O02323", "WBGene00002259", "O02324", "WBGene00002260", "species_5334816" ] }, "reaction_10551862": { "compartment": "compartment_70101", "id": "reaction_10551862", "reactome": "R-CEL-5419165", "name": "RDH11,14,DHRS3,DRHS4 reduce atRAL to atROL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_975622", "species_29364" ], "products": [ "species_29366", "species_975599" ], "modifiers": [ [ "species_10551859", "catalyst" ] ], "additional_components": [ "P91013", "WBGene00000965", "Q1XFZ3", "WBGene00000980", "A5JYX5", "WBGene00000967", "O18030", "WBGene00000968", "Q19843", "WBGene00000992", "Q22392", "WBGene00000982", "G5EGA6", "WBGene00010063" ] }, "reaction_10551768": { "compartment": "compartment_70101", "id": "reaction_10551768", "reactome": "R-CEL-5362564", "name": "ADH1A,1C,4 oxidise atROL to atRAL in vitro", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_975599", "species_29360" ], "products": [ "species_70106", "species_975622", "species_73473" ], "modifiers": [ [ "species_10551765", "catalyst" ] ], "additional_components": [ "species_216785", "Q17335", "WBGene00019240" ] }, "reaction_10557581": { "compartment": "compartment_70101", "id": "reaction_10557581", "reactome": "R-CEL-5696101", "name": "ALDH8A1 oxidises 9cRAL to 9cRA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_5362565", "species_29360" ], "products": [ "species_70106", "species_5362520", "species_73473" ], "modifiers": [ [ "species_10557578", "catalyst" ] ], "additional_components": [ "WBGene00000116" ] }, "reaction_10554022": { "compartment": "compartment_70101", "id": "reaction_10554022", "reactome": "R-CEL-5633256", "name": "FABP5:atRA translocates from cytosol to nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10553121" ], "products": [ "species_10552335" ], "modifiers": [], "additional_components": [ "species_5334816", "Q965W1", "WBGene00021486", "species_5334816", "Q965W1", "WBGene00021486" ] }, "reaction_10554024": { "compartment": "compartment_7660", "id": "reaction_10554024", "reactome": "R-CEL-5634100", "name": "FABP5 dissociates from RXRA:PPARD:atRA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10552337" ], "products": [ "species_10552333", "species_10514503" ], "modifiers": [], "additional_components": [ "Q9XUK7", "WBGene00003675", "P41830", "WBGene00004786", "Q10902", "WBGene00003601", "Q20765", "WBGene00003606", "Q9U2R6", "WBGene00003681", "species_5334816", "Q965W1", "WBGene00021486", "WBGene00021486", "Q9XUK7", "WBGene00003675", "P41830", "WBGene00004786", "Q10902", "WBGene00003601", "Q20765", "WBGene00003606", "Q9U2R6", "WBGene00003681", "species_5334816" ] }, "reaction_10514505": { "compartment": "compartment_70101", "id": "reaction_10514505", "reactome": "R-CEL-200406", "name": "CPT1A,B transfers PALM to CAR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_549207", "species_200993" ], "products": [ "species_201034", "species_76194" ], "modifiers": [ [ "species_10514471", "catalyst" ], [ "species_10514503", "catalyst" ], [ "species_29508", "inhibitor" ] ], "additional_components": [ "Q9N3N3", "WBGene00021703", "O16992", "WBGene00021002", "Q9U2F2", "WBGene00012907", "O44619", "WBGene00019644", "Q23066", "WBGene00020911", "G5EG54", "WBGene00008629", "Q9XUK7", "WBGene00003675", "P41830", "WBGene00004786", "Q10902", "WBGene00003601", "Q20765", "WBGene00003606", "Q9U2R6", "WBGene00003681", "species_5334816" ] }, "reaction_10554028": { "compartment": "compartment_7660", "id": "reaction_10554028", "reactome": "R-CEL-5634103", "name": "SUMO-CRABP2 dissociates from atRA:RAR:RXR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10551438" ], "products": [ "species_10551434", "species_10554026" ], "modifiers": [], "additional_components": [ "Q9U2R6", "WBGene00003681", "Q20765", "WBGene00003606", "P41830", "WBGene00004786", "Q9XUK7", "WBGene00003675", "Q10902", "WBGene00003601", "species_5334816", "O01812", "WBGene00002258", "WBGene00002258", "species_5334816", "Q9U2R6", "WBGene00003681", "Q20765", "WBGene00003606", "P41830", "WBGene00004786", "Q9XUK7", "WBGene00003675", "Q10902", "WBGene00003601" ] }, "reaction_10551391": { "compartment": "compartment_70101", "id": "reaction_10551391", "reactome": "R-CEL-5334827", "name": "SUMO-CRABP2 binds atRA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10551387", "species_5334816" ], "products": [ "species_10551389" ], "modifiers": [], "additional_components": [ "WBGene00002258", "species_5334816", "O01812", "WBGene00002258" ] }, "reaction_10554030": { "compartment": "compartment_70101", "id": "reaction_10554030", "reactome": "R-CEL-5634104", "name": "SUMO-CRABP2:atRA translocates from cytosol to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10551389" ], "products": [ "species_10551436" ], "modifiers": [], "additional_components": [ "species_5334816", "O01812", "WBGene00002258", "species_5334816", "O01812", "WBGene00002258" ] }, "reaction_10570912": { "compartment": "compartment_7660", "id": "reaction_10570912", "reactome": "R-CEL-9012319", "name": "p-TEFb phosphorylates serine 2 in RNA polymerase II CTD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10570907" ], "products": [ "species_113582", "species_10570909" ], "modifiers": [ [ "species_10570907", "catalyst" ] ], "additional_components": [ "Q9TVL3", "WBGene00000410", "P34424", "WBGene00000508", "P34425", "WBGene00000507", "species_1254400", "P16356", "WBGene00000123", "Q19826", "WBGene00017830", "Q9XVH6", "WBGene00012187", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q9U3I0", "WBGene00009078", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q10578", "WBGene00016140", "Q17684", "WBGene00007355", "O02092", "WBGene00018391", "Q9GR61", "WBGene00021347", "Q9N3C9", "WBGene00021845", "Q93338", "WBGene00007971", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q9TVL3", "WBGene00000410", "P34424", "WBGene00000508", "P34425", "WBGene00000507", "species_1254400", "Q9TVL3", "WBGene00000410", "P34424", "WBGene00000508", "P34425", "WBGene00000507", "species_1254400", "P16356", "WBGene00000123", "Q19826", "WBGene00017830", "Q9XVH6", "WBGene00012187", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q9U3I0", "WBGene00009078", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q10578", "WBGene00016140", "Q17684", "WBGene00007355", "O02092", "WBGene00018391", "Q9GR61", "WBGene00021347", "Q9N3C9", "WBGene00021845", "Q93338", "WBGene00007971" ] }, "reaction_10570805": { "compartment": "compartment_7660", "id": "reaction_10570805", "reactome": "R-CEL-9009533", "name": "TBP and TFIIA bind TATA box on ESR1:estrogen bound TFF1 gene promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10506254", "species_10506433", "species_10570801" ], "products": [ "species_10570803" ], "modifiers": [], "additional_components": [ "WBGene00006542", "O44625", "WBGene00004136", "Q9NEX2", "WBGene00013736", "Q9XUW5", "WBGene00010260", "CHEBI:142773", "species_5696848", "species_176619", "CHEBI:27974", "G5EGN3", "WBGene00001253", "P28515", "WBGene00001249", "Q9XUW7", "WBGene00001311", "G5EF25", "WBGene00003181", "G5EF71", "WBGene00003180", "U4PMB4", "WBGene00001186", "Q21187", "WBGene00001441", "Q17381", "WBGene00004013", "Q9XUW5", "WBGene00010260", "CHEBI:142773", "species_5696848", "species_176619", "CHEBI:27974", "G5EGN3", "WBGene00001253", "P28515", "WBGene00001249", "Q9XUW7", "WBGene00001311", "G5EF25", "WBGene00003181", "G5EF71", "WBGene00003180", "U4PMB4", "WBGene00001186", "Q21187", "WBGene00001441", "Q17381", "WBGene00004013", "O44625", "WBGene00004136", "Q9NEX2", "WBGene00013736", "P32085", "WBGene00006542" ] }, "reaction_10570772": { "compartment": "compartment_7660", "id": "reaction_10570772", "reactome": "R-CEL-9009065", "name": "FOXA1 and GATA3 bind to CCND1 promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10570727", "species_10570739", "species_10570768" ], "products": [ "species_10532119", "species_10570725", "species_10570770" ], "modifiers": [], "additional_components": [ "P45972", "WBGene00011639", "G5ECH0", "WBGene00001836", "P62784", "WBGene00001875", "Q10453", "WBGene00001945", "K7ZUH9", "WBGene00001914", "Q21187", "WBGene00001441", "Q17381", "WBGene00004013", "G5EGN3", "WBGene00001253", "P28515", "WBGene00001249", "Q9XUW7", "WBGene00001311", "G5EF25", "WBGene00003181", "G5EF71", "WBGene00003180", "U4PMB4", "WBGene00001186", "WBGene00001836", "WBGene00011639", "G5EGN3", "WBGene00001253", "P28515", "WBGene00001249", "Q9XUW7", "WBGene00001311", "G5EF25", "WBGene00003181", "G5EF71", "WBGene00003180", "U4PMB4", "WBGene00001186", "Q21187", "WBGene00001441", "Q17381", "WBGene00004013", "P62784", "WBGene00001875", "Q10453", "WBGene00001945", "K7ZUH9", "WBGene00001914" ] }, "reaction_10571524": { "compartment": "compartment_7660", "id": "reaction_10571524", "reactome": "R-CEL-9023860", "name": "Histone acetyltransferases are recruited to the TFF1 gene", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10571512", "species_10571520" ], "products": [ "species_10571522" ], "modifiers": [], "additional_components": [ "Q9TYU5", "WBGene00007029", "P34545", "WBGene00000366", "Q9N3S7", "WBGene00021636", "Q9XUW5", "WBGene00010260", "CHEBI:142773", "species_5696848", "species_176619", "CHEBI:27974", "G5EGN3", "WBGene00001253", "P28515", "WBGene00001249", "Q9XUW7", "WBGene00001311", "G5EF25", "WBGene00003181", "G5EF71", "WBGene00003180", "U4PMB4", "WBGene00001186", "Q21187", "WBGene00001441", "Q17381", "WBGene00004013", "O44625", "WBGene00004136", "Q9NEX2", "WBGene00013736", "P32085", "WBGene00006542", "Q9U2X0", "WBGene00013766", "Q9XUW5", "WBGene00010260", "CHEBI:142773", "species_5696848", "species_176619", "CHEBI:27974", "G5EGN3", "WBGene00001253", "P28515", "WBGene00001249", "Q9XUW7", "WBGene00001311", "G5EF25", "WBGene00003181", "G5EF71", "WBGene00003180", "U4PMB4", "WBGene00001186", "Q21187", "WBGene00001441", "Q17381", "WBGene00004013", "O44625", "WBGene00004136", "Q9NEX2", "WBGene00013736", "P32085", "WBGene00006542", "Q9U2X0", "WBGene00013766", "Q9TYU5", "WBGene00007029", "P34545", "WBGene00000366", "Q9N3S7", "WBGene00021636" ] }, "reaction_10571526": { "compartment": "compartment_7660", "id": "reaction_10571526", "reactome": "R-CEL-9023861", "name": "PRMT1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546564", "species_10570803" ], "products": [ "species_10571518" ], "modifiers": [], "additional_components": [ "WBGene00013766", "Q9XUW5", "WBGene00010260", "CHEBI:142773", "species_5696848", "species_176619", "CHEBI:27974", "G5EGN3", "WBGene00001253", "P28515", "WBGene00001249", "Q9XUW7", "WBGene00001311", "G5EF25", "WBGene00003181", "G5EF71", "WBGene00003180", "U4PMB4", "WBGene00001186", "Q21187", "WBGene00001441", "Q17381", "WBGene00004013", "O44625", "WBGene00004136", "Q9NEX2", "WBGene00013736", "P32085", "WBGene00006542", "Q9XUW5", "WBGene00010260", "CHEBI:142773", "species_5696848", "species_176619", "CHEBI:27974", "G5EGN3", "WBGene00001253", "P28515", "WBGene00001249", "Q9XUW7", "WBGene00001311", "G5EF25", "WBGene00003181", "G5EF71", "WBGene00003180", "U4PMB4", "WBGene00001186", "Q21187", "WBGene00001441", "Q17381", "WBGene00004013", "O44625", "WBGene00004136", "Q9NEX2", "WBGene00013736", "P32085", "WBGene00006542", "Q9U2X0", "WBGene00013766" ] }, "reaction_10568500": { "compartment": "compartment_7660", "id": "reaction_10568500", "reactome": "R-CEL-8939204", "name": "ESTG binds ESR1:chaperone complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10568488", "species_1254400" ], "products": [ "species_10568490" ], "modifiers": [], "additional_components": [ "Q09637", "WBGene00000885", "Q18688", "WBGene00000915", "species_29358", "Q23280", "WBGene00022599", "species_1254400", "Q09637", "WBGene00000885", "Q18688", "WBGene00000915", "species_29358", "Q23280", "WBGene00022599" ] }, "reaction_10573334": { "compartment": "compartment_7660", "id": "reaction_10573334", "reactome": "R-CEL-9709547", "name": "ESTG binds ESR2:chaperone complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10568494", "species_1254400" ], "products": [ "species_10568496" ], "modifiers": [], "additional_components": [ "Q09637", "WBGene00000885", "Q18688", "WBGene00000915", "species_29358", "Q23280", "WBGene00022599", "species_1254400", "Q09637", "WBGene00000885", "Q18688", "WBGene00000915", "species_29358", "Q23280", "WBGene00022599" ] }, "reaction_10515169": { "compartment": "compartment_70101", "id": "reaction_10515169", "reactome": "R-CEL-202127", "name": "eNOS synthesizes NO", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29468", "species_29368", "species_29364" ], "products": [ "species_202124", "species_29366", "species_29968" ], "modifiers": [ [ "species_10515166", "catalyst" ], [ "species_5693375", "inhibitor" ] ], "additional_components": [ "Q9XTG7", "WBGene00000103", "G4S4W1", "WBGene00016980", "Q17941", "WBGene00000102", "species_74016", "Q11083", "WBGene00020378", "P04630", "WBGene00000285", "G5EF37", "WBGene00003934", "A0A2C9C3L3", "WBGene00020378", "Q18136", "WBGene00006861", "Q09665", "WBGene00006583", "O02159", "WBGene00020378", "G5EDZ8", "WBGene00000288", "Q94288", "WBGene00000287", "Q09980", "WBGene00017394", "O16305", "WBGene00000552", "G5EEG0", "WBGene00000286", "Q18688", "WBGene00000915", "species_71185", "species_216785", "species_73524", "species_113596", "species_29870" ] }, "reaction_10572255": { "compartment": "compartment_7660", "id": "reaction_10572255", "reactome": "R-CEL-9624526", "name": "AKT phosphorylates FOXO3 downstream of ESR1 and EGFR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10514276" ], "products": [ "species_113582", "species_10514290" ], "modifiers": [ [ "species_10514266", "catalyst" ] ], "additional_components": [ "WBGene00000912", "WBGene00000912", "G4S4W1", "WBGene00016980", "Q17941", "WBGene00000102", "Q9XTG7", "WBGene00000103" ] }, "reaction_10572334": { "compartment": "compartment_7660", "id": "reaction_10572334", "reactome": "R-CEL-9632873", "name": "p-S10 CDKN1B translocates to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10572330" ], "products": [ "species_10572332" ], "modifiers": [ [ "species_10514056", "catalyst" ], [ "species_10511186", "catalyst" ] ], "additional_components": [ "WBGene00000517", "WBGene00000517", "P39745", "WBGene00003401", "WBGene00002078" ] }, "reaction_10572317": { "compartment": "compartment_70101", "id": "reaction_10572317", "reactome": "R-CEL-9632412", "name": "PTK2 is recruited to methylated ESR1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10572313", "species_10572310" ], "products": [ "species_10572315" ], "modifiers": [], "additional_components": [ "WBGene00002213", "A0A486WY88", "WBGene00010631", "species_1254400", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "G5EDP9", "WBGene00000001", "Q94125", "WBGene00000090", "A0A486WY88", "WBGene00010631", "species_1254400", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "G5EDP9", "WBGene00000001", "Q94125", "WBGene00000090", "Q95YD4", "WBGene00002213" ] }, "reaction_10572284": { "compartment": "compartment_876", "id": "reaction_10572284", "reactome": "R-CEL-9625814", "name": "SPHK1 phosphorylates sphingosine in response to E2 stimulation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1606609" ], "products": [ "species_5218688" ], "modifiers": [ [ "species_10520872", "catalyst" ] ], "additional_components": [ "WBGene00007918" ] }, "reaction_10572339": { "compartment": "compartment_876", "id": "reaction_10572339", "reactome": "R-CEL-9632906", "name": "PRKCZ recruits RAS in response to estrogen stimulation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10512175", "species_10572324" ], "products": [ "species_10572337" ], "modifiers": [], "additional_components": [ "species_29420", "P22981", "WBGene00002335", "Q9UA62", "WBGene00021022", "species_179838", "Q19266", "WBGene00004034", "Q9UA62", "WBGene00021022", "species_179838", "Q19266", "WBGene00004034", "species_29420", "P22981", "WBGene00002335" ] }, "reaction_10572327": { "compartment": "compartment_876", "id": "reaction_10572327", "reactome": "R-CEL-9632858", "name": "PRKCZ autophosphorylates downstream of estrogen stimulation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10572319", "species_113592" ], "products": [ "species_29370", "species_10572324" ], "modifiers": [ [ "species_10572319", "catalyst" ] ], "additional_components": [ "Q9UA62", "WBGene00021022", "species_179838", "Q19266", "WBGene00004034", "Q9UA62", "WBGene00021022", "species_179838", "Q19266", "WBGene00004034", "Q9UA62", "WBGene00021022", "species_179838", "Q19266", "WBGene00004034" ] }, "reaction_10572343": { "compartment": "compartment_7660", "id": "reaction_10572343", "reactome": "R-CEL-9632910", "name": "ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10542080" ], "products": [ "species_10514056" ], "modifiers": [ [ "species_10572341", "catalyst" ] ], "additional_components": [ "P39745", "WBGene00003401", "P39745", "WBGene00003401", "Q9UA62", "WBGene00021022", "species_179838", "Q19266", "WBGene00004034", "species_29438", "P22981", "WBGene00002335" ] }, "reaction_10572346": { "compartment": "compartment_876", "id": "reaction_10572346", "reactome": "R-CEL-9632918", "name": "PRKCZ stimulates RAS nucleotide exchange in response to estrogen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10572337" ], "products": [ "species_10572341" ], "modifiers": [], "additional_components": [ "Q9UA62", "WBGene00021022", "species_179838", "Q19266", "WBGene00004034", "species_29420", "P22981", "WBGene00002335", "Q9UA62", "WBGene00021022", "species_179838", "Q19266", "WBGene00004034", "species_29438", "P22981", "WBGene00002335" ] }, "reaction_10571584": { "compartment": "compartment_7660", "id": "reaction_10571584", "reactome": "R-CEL-9029566", "name": "Co-repressor complex dissociates from the transcription unit of the UGT1A3 gene ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10571574" ], "products": [ "species_10571582", "species_10517933" ], "modifiers": [], "additional_components": [ "G5ECR9", "WBGene00006790", "Q9U2R6", "WBGene00003681", "CHEBI:34310", "CHEBI:67237", "CHEBI:76591", "CHEBI:41633", "P34333", "WBGene00001565", "G5ECR9", "WBGene00006790", "Q9U2R6", "WBGene00003681", "CHEBI:34310", "CHEBI:67237", "CHEBI:76591", "CHEBI:41633", "WBGene00001565" ] }, "reaction_10571576": { "compartment": "compartment_7660", "id": "reaction_10571576", "reactome": "R-CEL-9029517", "name": "Oxysterol binds to the UGT1A3 gene:NR1H2,3:RXR:NCOR complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9024383", "species_10571572" ], "products": [ "species_10571574" ], "modifiers": [], "additional_components": [ "CHEBI:34310", "CHEBI:67237", "CHEBI:76591", "CHEBI:41633", "G5ECR9", "WBGene00006790", "Q9U2R6", "WBGene00003681", "P34333", "WBGene00001565", "G5ECR9", "WBGene00006790", "Q9U2R6", "WBGene00003681", "CHEBI:34310", "CHEBI:67237", "CHEBI:76591", "CHEBI:41633", "P34333", "WBGene00001565" ] }, "reaction_10537280": { "compartment": "compartment_20699", "id": "reaction_10537280", "reactome": "R-CEL-1676133", "name": "PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806217" ], "products": [ "species_29372", "species_1524146" ], "modifiers": [ [ "species_10537269", "catalyst" ] ], "additional_components": [ "WBGene00009264" ] }, "reaction_10537217": { "compartment": "compartment_20699", "id": "reaction_10537217", "reactome": "R-CEL-1675961", "name": "PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1524146" ], "products": [ "species_29370", "species_1806159" ], "modifiers": [ [ "species_10537193", "catalyst" ] ], "additional_components": [ "Q9TXI7", "WBGene00006932", "species_266099", "Q23669", "WBGene00014151", "G5EDY0", "WBGene00009552", "species_74016", "species_114632" ] }, "reaction_10537185": { "compartment": "compartment_20699", "id": "reaction_10537185", "reactome": "R-CEL-1675928", "name": "PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A/G at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1806217" ], "products": [ "species_1806230", "species_29370" ], "modifiers": [ [ "species_10537182", "catalyst" ] ], "additional_components": [ "G5EDY0", "WBGene00009552", "species_74016", "species_114632" ] }, "reaction_10537298": { "compartment": "compartment_20699", "id": "reaction_10537298", "reactome": "R-CEL-1676152", "name": "PI4KB binds to ARF1/3:GTP at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10537169", "species_10537296" ], "products": [ "species_10537171" ], "modifiers": [], "additional_components": [ "G5EFK4", "WBGene00000183", "species_29438", "Q10943", "WBGene00000182", "WBGene00018076", "G5EFK4", "WBGene00000183", "species_29438", "Q10943", "WBGene00000182", "Q20077", "WBGene00018076" ] }, "reaction_10537141": { "compartment": "compartment_20699", "id": "reaction_10537141", "reactome": "R-CEL-1675824", "name": "PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806165", "species_29356" ], "products": [ "species_29372", "species_1806217" ], "modifiers": [ [ "species_10537138", "catalyst" ] ], "additional_components": [ "WBGene00007620" ] }, "reaction_10537174": { "compartment": "compartment_20699", "id": "reaction_10537174", "reactome": "R-CEL-1675883", "name": "PI is phosphorylated to PI4P by PI4KB at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1524146" ], "products": [ "species_29370", "species_1806217" ], "modifiers": [ [ "species_10537171", "catalyst" ] ], "additional_components": [ "G5EFK4", "WBGene00000183", "species_29438", "Q10943", "WBGene00000182", "Q20077", "WBGene00018076" ] }, "reaction_10537272": { "compartment": "compartment_20699", "id": "reaction_10537272", "reactome": "R-CEL-1676114", "name": "PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1806159" ], "products": [ "species_29372", "species_1524146" ], "modifiers": [ [ "species_10537269", "catalyst" ] ], "additional_components": [ "WBGene00009264" ] }, "reaction_10537322": { "compartment": "compartment_20699", "id": "reaction_10537322", "reactome": "R-CEL-1676185", "name": "PI is phosphorylated to PI4P by PI4KA/2A/2B at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1524146" ], "products": [ "species_29370", "species_1806217" ], "modifiers": [ [ "species_10537319", "catalyst" ] ], "additional_components": [ "O45318", "WBGene00022501", "Q23083", "WBGene00022501", "Q9XW63", "WBGene00013557" ] }, "reaction_10502079": { "compartment": "compartment_7660", "id": "reaction_10502079", "reactome": "R-CEL-68611", "name": "Orc1 associates with Orc4:Orc5:Orc3:Orc2:origin complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502075", "species_10502070" ], "products": [ "species_10502077" ], "modifiers": [], "additional_components": [ "WBGene00012650", "Q9XX16", "WBGene00012651", "Q21037", "WBGene00003882", "Q23249", "WBGene00013857", "Q9XX16", "WBGene00012651", "Q21037", "WBGene00003882", "Q23249", "WBGene00013857", "Q9XX17", "WBGene00012650" ] }, "reaction_10548052": { "compartment": "compartment_70101", "id": "reaction_10548052", "reactome": "R-CEL-3772435", "name": "WNT signaling stimulates CSNK1-dependent phosphorylation of DVL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10515075" ], "products": [ "species_29370", "species_10515002" ], "modifiers": [ [ "species_10548049", "catalyst" ] ], "additional_components": [ "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "WBGene00002203" ] }, "reaction_10548055": { "compartment": "compartment_70101", "id": "reaction_10548055", "reactome": "R-CEL-3772436", "name": "DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_392417" ], "products": [ "species_29370", "species_179856" ], "modifiers": [ [ "species_10548042", "catalyst" ] ], "additional_components": [ "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "O01759", "WBGene00004087" ] }, "reaction_10515100": { "compartment": "compartment_70101", "id": "reaction_10515100", "reactome": "R-CEL-201717", "name": "CSNK2-mediated phosphorylation of DVL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10515052", "species_113592" ], "products": [ "species_29370", "species_10515075" ], "modifiers": [ [ "species_10515097", "catalyst" ] ], "additional_components": [ "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "P18334", "WBGene00002191", "P28548", "WBGene00002196" ] }, "reaction_10548044": { "compartment": "compartment_70101", "id": "reaction_10548044", "reactome": "R-CEL-3772434", "name": "Phosphorylated DVL recruits PIP5K1B to the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10537053", "species_10515002" ], "products": [ "species_10548042" ], "modifiers": [], "additional_components": [ "WBGene00004087", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "O01759", "WBGene00004087" ] }, "reaction_10573013": { "compartment": "compartment_70101", "id": "reaction_10573013", "reactome": "R-CEL-9667965", "name": "ANKLE2 binds PP2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546138", "species_10529273" ], "products": [ "species_10573011" ], "modifiers": [], "additional_components": [ "WBGene00021945", "Q09543", "WBGene00003901", "G5EDR3", "WBGene00006352", "G5EGK8", "WBGene00002363", "Q09543", "WBGene00003901", "G5EDR3", "WBGene00006352", "G5EGK8", "WBGene00002363", "H2KZB2", "WBGene00021945" ] }, "reaction_10546149": { "compartment": "compartment_70101", "id": "reaction_10546149", "reactome": "R-CEL-2995389", "name": "ANKLE2 binds VRK1,(VRK2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546143", "species_10546138" ], "products": [ "species_10546147" ], "modifiers": [], "additional_components": [ "WBGene00017895", "WBGene00021945", "H2KZB2", "WBGene00021945", "Q19848", "WBGene00017895" ] }, "reaction_10572275": { "compartment": "compartment_1598585", "id": "reaction_10572275", "reactome": "R-CEL-9624845", "name": "RCC1 stimulates GDP to GTP exchange on RAN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10558002" ], "products": [ "species_29420", "species_10572267" ], "modifiers": [ [ "species_10572272", "catalyst" ] ], "additional_components": [ "O17915", "WBGene00004302", "species_29420", "O17915", "WBGene00004302", "species_29438", "WBGene00004304" ] }, "reaction_10572213": { "compartment": "compartment_70101", "id": "reaction_10572213", "reactome": "R-CEL-9618378", "name": "POM121 binds the Nup107-Nup160 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10507233", "species_10572209" ], "products": [ "species_10572211" ], "modifiers": [], "additional_components": [ "WBGene00003800", "P34343", "WBGene00003801", "Q17872", "WBGene00007493", "Q8T8M4", "WBGene00003792", "Q9N4A7", "WBGene00003806", "Q22078", "WBGene00003788", "O45933", "WBGene00003804", "Q19131", "WBGene00003791", "G5EEH9", "WBGene00003796", "P34343", "WBGene00003801", "Q17872", "WBGene00007493", "Q8T8M4", "WBGene00003792", "Q9N4A7", "WBGene00003806", "Q22078", "WBGene00003788", "O45933", "WBGene00003804", "Q19131", "WBGene00003791", "G5EEH9", "WBGene00003796", "Q17602", "WBGene00003800" ] }, "reaction_10572279": { "compartment": "compartment_70101", "id": "reaction_10572279", "reactome": "R-CEL-9624876", "name": "RAN:GTP recruits nuclear envelope (NE) membranes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9624879", "species_10572267" ], "products": [ "species_10572277" ], "modifiers": [], "additional_components": [ "O17915", "WBGene00004302", "species_29438", "O17915", "WBGene00004302", "species_29438" ] }, "reaction_10572282": { "compartment": "compartment_70101", "id": "reaction_10572282", "reactome": "R-CEL-9624893", "name": "RAN stimulates fusion of nuclear envelope (NE) membranes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10572277" ], "products": [ "species_29372", "species_9624890", "species_10558002" ], "modifiers": [ [ "species_10546252", "catalyst" ] ], "additional_components": [ "O17915", "WBGene00004302", "species_29438", "O17915", "WBGene00004302", "species_29420", "P34342", "WBGene00004303", "P55853", "WBGene00004888" ] }, "reaction_10573042": { "compartment": "compartment_70101", "id": "reaction_10573042", "reactome": "R-CEL-9668389", "name": "VPS4 binds ESCRT-III assemblies at nuclear envelope (NE) fenestrations", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10573038", "species_10573033" ], "products": [ "species_10573040" ], "modifiers": [], "additional_components": [ "WBGene00021334", "Q9U2M8", "WBGene00012578", "G5ECX8", "WBGene00010736", "Q9XTB5", "WBGene00002275", "Q9GYK4", "WBGene00020866", "Q9BL60", "WBGene00022027", "Q9U2F6", "WBGene00012903", "O02208", "WBGene00007216", "Q22718", "WBGene00011976", "Q18886", "WBGene00016961", "Q21959", "WBGene00020025", "Q8MNV0", "WBGene00016045", "Q9U2M8", "WBGene00012578", "G5ECX8", "WBGene00010736", "Q9XTB5", "WBGene00002275", "Q9GYK4", "WBGene00020866", "Q9BL60", "WBGene00022027", "Q9U2F6", "WBGene00012903", "O02208", "WBGene00007216", "Q22718", "WBGene00011976", "Q18886", "WBGene00016961", "Q21959", "WBGene00020025", "Q8MNV0", "WBGene00016045", "Q9BL83", "WBGene00021334" ] }, "reaction_10573044": { "compartment": "compartment_13231", "id": "reaction_10573044", "reactome": "R-CEL-9668395", "name": "CHMP7 binds CC2D1B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10573029", "species_10573025" ], "products": [ "species_10573031" ], "modifiers": [], "additional_components": [ "G5ECX8", "WBGene00010736", "Q9XTB5", "WBGene00002275", "Q9GYK4", "WBGene00020866", "Q9BL60", "WBGene00022027", "Q9U2F6", "WBGene00012903", "O02208", "WBGene00007216", "Q22718", "WBGene00011976", "Q18886", "WBGene00016961", "Q21959", "WBGene00020025", "WBGene00012578", "Q9U2M8", "WBGene00012578", "G5ECX8", "WBGene00010736", "Q9XTB5", "WBGene00002275", "Q9GYK4", "WBGene00020866", "Q9BL60", "WBGene00022027", "Q9U2F6", "WBGene00012903", "O02208", "WBGene00007216", "Q22718", "WBGene00011976", "Q18886", "WBGene00016961", "Q21959", "WBGene00020025" ] }, "reaction_10573046": { "compartment": "compartment_70101", "id": "reaction_10573046", "reactome": "R-CEL-9668405", "name": "SPAST (spastin) binds the IST1 subunit of ESCRT-III at the sites of microtubule attachment to chromatin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10573020", "species_10573031" ], "products": [ "species_10573033" ], "modifiers": [], "additional_components": [ "WBGene00016045", "Q9U2M8", "WBGene00012578", "G5ECX8", "WBGene00010736", "Q9XTB5", "WBGene00002275", "Q9GYK4", "WBGene00020866", "Q9BL60", "WBGene00022027", "Q9U2F6", "WBGene00012903", "O02208", "WBGene00007216", "Q22718", "WBGene00011976", "Q18886", "WBGene00016961", "Q21959", "WBGene00020025", "Q9U2M8", "WBGene00012578", "G5ECX8", "WBGene00010736", "Q9XTB5", "WBGene00002275", "Q9GYK4", "WBGene00020866", "Q9BL60", "WBGene00022027", "Q9U2F6", "WBGene00012903", "O02208", "WBGene00007216", "Q22718", "WBGene00011976", "Q18886", "WBGene00016961", "Q21959", "WBGene00020025", "Q8MNV0", "WBGene00016045" ] }, "reaction_10544436": { "compartment": "compartment_70101", "id": "reaction_10544436", "reactome": "R-CEL-2467775", "name": "Autocleavage of ESPL1 (Separase)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10544425" ], "products": [ "species_10544433" ], "modifiers": [ [ "species_10544425", "catalyst" ] ], "additional_components": [ "WBGene00004775", "G5ED39", "WBGene00004775", "WBGene00004775" ] }, "reaction_10509875": { "compartment": "compartment_7660", "id": "reaction_10509875", "reactome": "R-CEL-156682", "name": "PLK1 phosphorylates NUDC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509869", "species_113592" ], "products": [ "species_29370", "species_10509873" ], "modifiers": [ [ "species_10509861", "catalyst" ] ], "additional_components": [ "WBGene00003829", "WBGene00003829", "WBGene00004043" ] }, "reaction_10572564": { "compartment": "compartment_70101", "id": "reaction_10572564", "reactome": "R-CEL-9647746", "name": "EML4 trimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10572560" ], "products": [ "species_10572562" ], "modifiers": [], "additional_components": [ "WBGene00001248", "O45487", "WBGene00001248" ] }, "reaction_10544760": { "compartment": "compartment_70101", "id": "reaction_10544760", "reactome": "R-CEL-2529015", "name": "Dephosphorylation of CK2-modified condensin I", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10544748" ], "products": [ "species_29372", "species_10544758" ], "modifiers": [ [ "species_2529006", "catalyst" ] ], "additional_components": [ "G5EFJ4", "WBGene00009254", "Q20060", "WBGene00004874", "Q09591", "WBGene00003367", "Q9U2M1", "WBGene00001087", "G5EFJ4", "WBGene00009254", "Q20060", "WBGene00004874", "Q09591", "WBGene00003367", "Q9U2M1", "WBGene00001087" ] }, "reaction_10544762": { "compartment": "compartment_70101", "id": "reaction_10544762", "reactome": "R-CEL-2529020", "name": "CK2 phosphorylates condensin I subunits", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10544758" ], "products": [ "species_10544748", "species_29370" ], "modifiers": [ [ "species_10515097", "catalyst" ] ], "additional_components": [ "G5EFJ4", "WBGene00009254", "Q20060", "WBGene00004874", "Q09591", "WBGene00003367", "Q9U2M1", "WBGene00001087", "G5EFJ4", "WBGene00009254", "Q20060", "WBGene00004874", "Q09591", "WBGene00003367", "Q9U2M1", "WBGene00001087", "P18334", "WBGene00002191", "P28548", "WBGene00002196" ] }, "reaction_10544517": { "compartment": "compartment_1598585", "id": "reaction_10544517", "reactome": "R-CEL-2468293", "name": "CDK1 phosphorylates CDCA5 (Sororin) at chromosomal arms", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10544514" ], "products": [ "species_29370", "species_10544390" ], "modifiers": [ [ "species_10511266", "catalyst" ] ], "additional_components": [ "H2L0H5", "WBGene00019953", "B2FDA8", "WBGene00004873", "Q19555", "WBGene00004738", "O01789", "WBGene00001860", "Q19325", "WBGene00004737", "Q9XUB3", "WBGene00004333", "G5EC05", "WBGene00001352", "H2L0H5", "WBGene00019953", "B2FDA8", "WBGene00004873", "Q19555", "WBGene00004738", "O01789", "WBGene00001860", "Q19325", "WBGene00004737", "Q9XUB3", "WBGene00004333", "G5EC05", "WBGene00001352", "Q10653", "WBGene00000865", "P34556", "WBGene00000405", "Q9BLB5", "WBGene00000867", "O45926", "WBGene00000866" ] }, "reaction_10544410": { "compartment": "compartment_1598585", "id": "reaction_10544410", "reactome": "R-CEL-2466068", "name": "Phosphorylation of cohesin by PLK1 at chromosomal arms", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10544390" ], "products": [ "species_29370", "species_10544407" ], "modifiers": [ [ "species_10511228", "catalyst" ] ], "additional_components": [ "H2L0H5", "WBGene00019953", "B2FDA8", "WBGene00004873", "Q19555", "WBGene00004738", "O01789", "WBGene00001860", "Q19325", "WBGene00004737", "Q9XUB3", "WBGene00004333", "G5EC05", "WBGene00001352", "H2L0H5", "WBGene00019953", "Q19325", "WBGene00004737", "Q9XUB3", "WBGene00004333", "B2FDA8", "WBGene00004873", "Q19555", "WBGene00004738", "O01789", "WBGene00001860", "G5EC05", "WBGene00001352", "WBGene00004043" ] }, "reaction_10544537": { "compartment": "compartment_1598585", "id": "reaction_10544537", "reactome": "R-CEL-2470935", "name": "Cohesin binding to decondensed chromatin is facilitated by NIPBL:MAU2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2537690", "species_10544484", "species_10544529" ], "products": [ "species_10544535" ], "modifiers": [], "additional_components": [ "H2L0H5", "WBGene00019953", "B2FDA8", "WBGene00004873", "Q19325", "WBGene00004737", "Q9XUB3", "WBGene00004333", "Q19555", "WBGene00004738", "O01789", "WBGene00001860", "G5EC05", "WBGene00001352", "O17581", "WBGene00003136", "Q95XZ5", "WBGene00004166", "O17581", "WBGene00003136", "Q95XZ5", "WBGene00004166", "H2L0H5", "WBGene00019953", "B2FDA8", "WBGene00004873", "Q19325", "WBGene00004737", "Q9XUB3", "WBGene00004333", "Q19555", "WBGene00004738", "O01789", "WBGene00001860", "G5EC05", "WBGene00001352" ] }, "reaction_10544508": { "compartment": "compartment_7660", "id": "reaction_10544508", "reactome": "R-CEL-2468040", "name": "Cohesin binds PDS5 and WAPAL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10544478", "species_10544476", "species_10544482" ], "products": [ "species_10544484" ], "modifiers": [], "additional_components": [ "WBGene00001352", "B2FDA8", "WBGene00004873", "Q19325", "WBGene00004737", "Q9XUB3", "WBGene00004333", "Q19555", "WBGene00004738", "O01789", "WBGene00001860", "WBGene00019953", "H2L0H5", "WBGene00019953", "B2FDA8", "WBGene00004873", "Q19325", "WBGene00004737", "Q9XUB3", "WBGene00004333", "Q19555", "WBGene00004738", "O01789", "WBGene00001860", "G5EC05", "WBGene00001352" ] }, "reaction_10509854": { "compartment": "compartment_7660", "id": "reaction_10509854", "reactome": "R-CEL-156673", "name": "Regulation of KIF23 (MKLP1) by phosphorylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10509841" ], "products": [ "species_113582", "species_10509845" ], "modifiers": [ [ "species_10509851", "catalyst" ] ], "additional_components": [ "WBGene00006974", "WBGene00006974", "WBGene00004043" ] }, "reaction_10569693": { "compartment": "compartment_17957", "id": "reaction_10569693", "reactome": "R-CEL-8952289", "name": "FAM20C phosphorylates FAM20C substrates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8931885", "species_10569440" ], "products": [ "species_10569686", "species_8931884" ], "modifiers": [ [ "species_10569440", "catalyst" ], [ "species_10569691", "catalyst" ] ], "additional_components": [ "Q9XTW2", "WBGene00010356", "P49713", "WBGene00012225", "Q22235", "WBGene00011480", "G5EFD9", "WBGene00006324", "H2L2L3", "WBGene00013326", "Q10651", "WBGene00000149", "G5EFX3", "WBGene00013416", "Q9XWD6", "WBGene00000415", "O44565", "WBGene00002247", "Q18823", "WBGene00016913", "Q17770", "WBGene00003963", "A9Z1L1", "WBGene00005648", "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "Q8WQF8", "WBGene00017220", "Q8WQF7", "WBGene00017220", "Q9GZD8", "WBGene00235368", "O01330", "WBGene00235368", "Q9GZD9", "WBGene00235368", "O01331", "WBGene00235368", "Q9GZE0", "WBGene00235368", "P36573", "WBGene00002264", "Q9N384", "WBGene00002269", "C4RVF6", "WBGene00235368", "Q09581", "WBGene00002266", "U4PM93", "WBGene00235368", "G5EFI4", "WBGene00002268", "Q18625", "WBGene00002267", "K8ERT0", "WBGene00235368", "Q20684", "WBGene00002265", "O01329", "WBGene00235368", "G5EBY8", "WBGene00006852", "G5EEL5", "WBGene00000936", "Q8MQ51", "WBGene00009674", "K8F7Z5", "WBGene00008735", "Q7YTU0", "WBGene00013969", "Q11067", "WBGene00015168", "Q11186", "WBGene00015484", "G5EC87", "WBGene00014249", "H2KZY5", "WBGene00018533", "G5EBH7", "WBGene00019760", "Q19687", "WBGene00009008", "P50605", "WBGene00004749", "G5ECM9", "WBGene00000534", "P34714", "WBGene00003893", "Q9N3E0", "WBGene00001046", "Q09EE8", "WBGene00044988", "Q5ZR75", "WBGene00020516", "Q9BL47", "WBGene00022175", "Q18096", "WBGene00007687", "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769", "Q9XTW2", "WBGene00010356", "G5EFD9", "WBGene00006324", "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "H2L2L3", "WBGene00013326", "P49713", "WBGene00012225", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "A9Z1L1", "WBGene00005648", "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "Q10651", "WBGene00000149", "Q9GZE0", "WBGene00235368", "Q9N384", "WBGene00002269", "K8ERT0", "WBGene00235368", "O01329", "WBGene00235368", "U4PM93", "WBGene00235368", "O01330", "WBGene00235368", "O01331", "WBGene00235368", "P36573", "WBGene00002264", "Q09581", "WBGene00002266", "Q18625", "WBGene00002267", "Q20684", "WBGene00002265", "Q9GZD8", "WBGene00235368", "Q9GZD9", "WBGene00235368", "C4RVF6", "WBGene00235368", "G5EFI4", "WBGene00002268", "Q8MQ51", "WBGene00009674", "G5EFX3", "WBGene00013416", "Q9XWD6", "WBGene00000415", "Q17770", "WBGene00003963", "Q8WQF7", "WBGene00017220", "Q8WQF8", "WBGene00017220", "Q22235", "WBGene00011480", "Q11067", "WBGene00015168", "O44565", "WBGene00002247", "Q11186", "WBGene00015484", "G5EC87", "WBGene00014249", "Q18823", "WBGene00016913", "G5EBY8", "WBGene00006852", "G5EEL5", "WBGene00000936", "H2KZY5", "WBGene00018533", "P50605", "WBGene00004749", "Q7YTU0", "WBGene00013969", "K8F7Z5", "WBGene00008735", "P34714", "WBGene00003893", "G5EBH7", "WBGene00019760", "Q09EE8", "WBGene00044988", "Q19687", "WBGene00009008", "Q9BL47", "WBGene00022175", "G5ECM9", "WBGene00000534", "Q18096", "WBGene00007687", "Q9N3E0", "WBGene00001046", "Q5ZR75", "WBGene00020516", "Q9XTW2", "WBGene00010356", "P49713", "WBGene00012225", "Q22235", "WBGene00011480", "G5EFD9", "WBGene00006324", "H2L2L3", "WBGene00013326", "Q10651", "WBGene00000149", "G5EFX3", "WBGene00013416", "Q9XWD6", "WBGene00000415", "O44565", "WBGene00002247", "Q18823", "WBGene00016913", "Q17770", "WBGene00003963", "A9Z1L1", "WBGene00005648", "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "Q8WQF8", "WBGene00017220", "Q8WQF7", "WBGene00017220", "Q9GZD8", "WBGene00235368", "O01330", "WBGene00235368", "Q9GZD9", "WBGene00235368", "O01331", "WBGene00235368", "Q9GZE0", "WBGene00235368", "P36573", "WBGene00002264", "Q9N384", "WBGene00002269", "C4RVF6", "WBGene00235368", "Q09581", "WBGene00002266", "U4PM93", "WBGene00235368", "G5EFI4", "WBGene00002268", "Q18625", "WBGene00002267", "K8ERT0", "WBGene00235368", "Q20684", "WBGene00002265", "O01329", "WBGene00235368", "G5EBY8", "WBGene00006852", "G5EEL5", "WBGene00000936", "Q8MQ51", "WBGene00009674", "K8F7Z5", "WBGene00008735", "Q7YTU0", "WBGene00013969", "Q11067", "WBGene00015168", "Q11186", "WBGene00015484", "G5EC87", "WBGene00014249", "H2KZY5", "WBGene00018533", "G5EBH7", "WBGene00019760", "Q19687", "WBGene00009008", "P50605", "WBGene00004749", "G5ECM9", "WBGene00000534", "P34714", "WBGene00003893", "Q9N3E0", "WBGene00001046", "Q09EE8", "WBGene00044988", "Q5ZR75", "WBGene00020516", "Q9BL47", "WBGene00022175", "Q18096", "WBGene00007687", "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769", "Q9XTW2", "WBGene00010356" ] }, "reaction_10554323": { "compartment": "compartment_70101", "id": "reaction_10554323", "reactome": "R-CEL-5653957", "name": "Rag dimer formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10510565", "species_10510578" ], "products": [ "species_10510580" ], "modifiers": [], "additional_components": [ "Q22743", "WBGene00006414", "species_29438", "species_29420", "G5EGB3", "WBGene00012497", "species_29420", "G5EGB3", "WBGene00012497", "Q22743", "WBGene00006414", "species_29438" ] }, "reaction_10554325": { "compartment": "compartment_17938", "id": "reaction_10554325", "reactome": "R-CEL-5653968", "name": "Ragulator:Rag dimers:SLC38A9 bind mTORC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10510526", "species_10510584" ], "products": [ "species_10510586" ], "modifiers": [], "additional_components": [ "P91040", "WBGene00015697", "Q95Q95", "WBGene00002583", "Q68TI8", "WBGene00000911", "Q19425", "WBGene00008774", "species_29420", "G5EGB3", "WBGene00012497", "Q22743", "WBGene00006414", "species_29438", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "Q19425", "WBGene00008774", "species_29420", "G5EGB3", "WBGene00012497", "Q22743", "WBGene00006414", "species_29438", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "P91040", "WBGene00015697", "Q95Q95", "WBGene00002583", "Q68TI8", "WBGene00000911" ] }, "reaction_10554902": { "compartment": "compartment_17938", "id": "reaction_10554902", "reactome": "R-CEL-5672828", "name": "mTORC1 phosphorylates AKT1S1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10510629" ], "products": [ "species_29370", "species_10554899" ], "modifiers": [ [ "species_10510629", "catalyst" ] ], "additional_components": [ "Q19425", "WBGene00008774", "species_29420", "G5EGB3", "WBGene00012497", "Q22743", "WBGene00006414", "species_29438", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "P91040", "WBGene00015697", "Q95Q95", "WBGene00002583", "Q68TI8", "WBGene00000911", "P34443", "WBGene00010038", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "Q19425", "WBGene00008774", "species_29420", "G5EGB3", "WBGene00012497", "Q22743", "WBGene00006414", "species_29438", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "P91040", "WBGene00015697", "Q95Q95", "WBGene00002583", "Q68TI8", "WBGene00000911", "P34443", "WBGene00010038", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "Q19425", "WBGene00008774", "species_29420", "G5EGB3", "WBGene00012497", "Q22743", "WBGene00006414", "species_29438", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "P91040", "WBGene00015697", "Q95Q95", "WBGene00002583", "Q68TI8", "WBGene00000911", "P34443", "WBGene00010038", "P41932", "WBGene00003920", "Q20655", "WBGene00001502" ] }, "reaction_10569771": { "compartment": "compartment_70101", "id": "reaction_10569771", "reactome": "R-CEL-8952726", "name": "SLC38A9 transports L-Arg from lysosomal lumen to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428011" ], "products": [ "species_29468" ], "modifiers": [ [ "species_10510584", "catalyst" ] ], "additional_components": [ "Q19425", "WBGene00008774", "species_29420", "G5EGB3", "WBGene00012497", "Q22743", "WBGene00006414", "species_29438", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390" ] }, "reaction_10554893": { "compartment": "compartment_17938", "id": "reaction_10554893", "reactome": "R-CEL-5672824", "name": "Phosphorylated AKT1S1:mTORC1 binds YWHAB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10507065", "species_10510627" ], "products": [ "species_10510629" ], "modifiers": [], "additional_components": [ "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "Q19425", "WBGene00008774", "species_29420", "G5EGB3", "WBGene00012497", "Q22743", "WBGene00006414", "species_29438", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "P91040", "WBGene00015697", "Q95Q95", "WBGene00002583", "Q68TI8", "WBGene00000911", "P34443", "WBGene00010038", "Q19425", "WBGene00008774", "species_29420", "G5EGB3", "WBGene00012497", "Q22743", "WBGene00006414", "species_29438", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "P91040", "WBGene00015697", "Q95Q95", "WBGene00002583", "Q68TI8", "WBGene00000911", "P34443", "WBGene00010038", "P41932", "WBGene00003920", "Q20655", "WBGene00001502" ] }, "reaction_10510643": { "compartment": "compartment_70101", "id": "reaction_10510643", "reactome": "R-CEL-165726", "name": "Phosphorylation of Ribosomal protein S6 by activated S6K1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10505506" ], "products": [ "species_29370", "species_10510640" ], "modifiers": [ [ "species_10510612", "catalyst" ] ], "additional_components": [ "WBGene00004475", "WBGene00004475", "Q9NAH6", "WBGene00012929", "Q21694", "WBGene00044281" ] }, "reaction_10510660": { "compartment": "compartment_70101", "id": "reaction_10510660", "reactome": "R-CEL-165766", "name": "Phosphorylation and activation of eIF4G by activated S6K1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10505665" ], "products": [ "species_29370", "species_10510658" ], "modifiers": [ [ "species_10510612", "catalyst" ] ], "additional_components": [ "WBGene00002066", "WBGene00002066", "Q9NAH6", "WBGene00012929", "Q21694", "WBGene00044281" ] }, "reaction_10510631": { "compartment": "compartment_17938", "id": "reaction_10510631", "reactome": "R-CEL-165718", "name": "mTORC1 phosphorylation of RPS6KB1 (S6K)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10510602", "species_113592" ], "products": [ "species_29370", "species_10510612" ], "modifiers": [ [ "species_10510588", "catalyst" ], [ "species_10510629", "catalyst" ], [ "species_10510623", "inhibitor" ] ], "additional_components": [ "Q21694", "WBGene00044281", "Q9NAH6", "WBGene00012929", "Q9NAH6", "WBGene00012929", "Q21694", "WBGene00044281", "Q19425", "WBGene00008774", "species_29420", "G5EGB3", "WBGene00012497", "Q22743", "WBGene00006414", "species_29438", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "P91040", "WBGene00015697", "Q95Q95", "WBGene00002583", "Q68TI8", "WBGene00000911", "P34443", "WBGene00010038", "Q19425", "WBGene00008774", "species_29420", "G5EGB3", "WBGene00012497", "Q22743", "WBGene00006414", "species_29438", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "P91040", "WBGene00015697", "Q95Q95", "WBGene00002583", "Q68TI8", "WBGene00000911", "P34443", "WBGene00010038", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "P34443", "WBGene00010038", "species_29438", "Q19425", "WBGene00008774", "species_29420", "G5EGB3", "WBGene00012497", "Q22743", "WBGene00006414", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "P91040", "WBGene00015697", "Q95Q95", "WBGene00002583", "Q68TI8", "WBGene00000911" ] }, "reaction_10510665": { "compartment": "compartment_70101", "id": "reaction_10510665", "reactome": "R-CEL-165777", "name": "Phosphorylation and activation of eIF4B by activated S6K1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10505672" ], "products": [ "species_29370", "species_10510663" ], "modifiers": [ [ "species_10510612", "catalyst" ] ], "additional_components": [ "WBGene00019157", "WBGene00019157", "Q9NAH6", "WBGene00012929", "Q21694", "WBGene00044281" ] }, "reaction_10510653": { "compartment": "compartment_70101", "id": "reaction_10510653", "reactome": "R-CEL-165758", "name": "Phosphorylation and inactivation of eEF2K by activated S6K1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10510648" ], "products": [ "species_10510651", "species_29370" ], "modifiers": [ [ "species_10510612", "catalyst" ] ], "additional_components": [ "WBGene00001160", "WBGene00001160", "Q9NAH6", "WBGene00012929", "Q21694", "WBGene00044281" ] }, "reaction_10519956": { "compartment": "compartment_70101", "id": "reaction_10519956", "reactome": "R-CEL-380930", "name": "Phosphorylated AMPK binds AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10514570", "species_76577" ], "products": [ "species_10519954" ], "modifiers": [], "additional_components": [ "Q9XUY2", "WBGene00010115", "P45894", "WBGene00019801", "Q95ZQ4", "WBGene00020142", "A0A1T5HUK9", "WBGene00013732", "H2L0K0", "WBGene00020135", "O02168", "WBGene00020633", "Q9N501", "WBGene00021527", "species_76577", "Q9XUY2", "WBGene00010115", "P45894", "WBGene00019801", "Q95ZQ4", "WBGene00020142", "A0A1T5HUK9", "WBGene00013732", "H2L0K0", "WBGene00020135", "O02168", "WBGene00020633", "Q9N501", "WBGene00021527" ] }, "reaction_10525223": { "compartment": "compartment_876", "id": "reaction_10525223", "reactome": "R-CEL-447074", "name": "AMPK phosphorylates Raptor in the mTORC1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10510588", "species_113592" ], "products": [ "species_10510623", "species_29370" ], "modifiers": [ [ "species_10519954", "catalyst" ] ], "additional_components": [ "Q19425", "WBGene00008774", "species_29420", "G5EGB3", "WBGene00012497", "Q22743", "WBGene00006414", "species_29438", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "P91040", "WBGene00015697", "Q95Q95", "WBGene00002583", "Q68TI8", "WBGene00000911", "P34443", "WBGene00010038", "P34443", "WBGene00010038", "species_29438", "Q19425", "WBGene00008774", "species_29420", "G5EGB3", "WBGene00012497", "Q22743", "WBGene00006414", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "P91040", "WBGene00015697", "Q95Q95", "WBGene00002583", "Q68TI8", "WBGene00000911", "species_76577", "Q9XUY2", "WBGene00010115", "P45894", "WBGene00019801", "Q95ZQ4", "WBGene00020142", "A0A1T5HUK9", "WBGene00013732", "H2L0K0", "WBGene00020135", "O02168", "WBGene00020633", "Q9N501", "WBGene00021527" ] }, "reaction_10519961": { "compartment": "compartment_70101", "id": "reaction_10519961", "reactome": "R-CEL-380949", "name": "AMPK is dephosphorylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10514570" ], "products": [ "species_29372", "species_10514555" ], "modifiers": [ [ "species_10519958", "catalyst" ] ], "additional_components": [ "Q9XUY2", "WBGene00010115", "P45894", "WBGene00019801", "Q95ZQ4", "WBGene00020142", "A0A1T5HUK9", "WBGene00013732", "H2L0K0", "WBGene00020135", "O02168", "WBGene00020633", "Q9N501", "WBGene00021527", "Q9XUY2", "WBGene00010115", "A0A1T5HUK9", "WBGene00013732", "H2L0K0", "WBGene00020135", "O02168", "WBGene00020633", "Q9N501", "WBGene00021527", "P45894", "WBGene00019801", "Q95ZQ4", "WBGene00020142", "WBGene00006460" ] }, "reaction_10510509": { "compartment": "compartment_17938", "id": "reaction_10510509", "reactome": "R-CEL-165195", "name": "GTP loading by Rheb", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10510505" ], "products": [ "species_29420", "species_10510507" ], "modifiers": [], "additional_components": [ "P34443", "WBGene00010038", "species_29420", "P34443", "WBGene00010038", "species_29438" ] }, "reaction_10510590": { "compartment": "compartment_70101", "id": "reaction_10510590", "reactome": "R-CEL-165680", "name": "Formation of active mTORC1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10510507", "species_10510586" ], "products": [ "species_10510588" ], "modifiers": [], "additional_components": [ "P34443", "WBGene00010038", "species_29438", "Q19425", "WBGene00008774", "species_29420", "G5EGB3", "WBGene00012497", "Q22743", "WBGene00006414", "species_29438", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "P91040", "WBGene00015697", "Q95Q95", "WBGene00002583", "Q68TI8", "WBGene00000911", "Q19425", "WBGene00008774", "species_29420", "G5EGB3", "WBGene00012497", "Q22743", "WBGene00006414", "species_29438", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "P91040", "WBGene00015697", "Q95Q95", "WBGene00002583", "Q68TI8", "WBGene00000911", "P34443", "WBGene00010038" ] }, "reaction_10519535": { "compartment": "compartment_17938", "id": "reaction_10519535", "reactome": "R-CEL-377186", "name": "Activated Akt1 phosphorylates AKT1S1 (PRAS40)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10519532", "species_113592" ], "products": [ "species_29370", "species_10510627" ], "modifiers": [ [ "species_10515152", "catalyst" ] ], "additional_components": [ "Q19425", "WBGene00008774", "species_29420", "G5EGB3", "WBGene00012497", "Q22743", "WBGene00006414", "species_29438", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "P91040", "WBGene00015697", "Q95Q95", "WBGene00002583", "Q68TI8", "WBGene00000911", "P34443", "WBGene00010038", "Q19425", "WBGene00008774", "species_29420", "G5EGB3", "WBGene00012497", "Q22743", "WBGene00006414", "species_29438", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "P91040", "WBGene00015697", "Q95Q95", "WBGene00002583", "Q68TI8", "WBGene00000911", "P34443", "WBGene00010038", "G4S4W1", "WBGene00016980", "Q17941", "WBGene00000102", "Q9XTG7", "WBGene00000103" ] }, "reaction_10509895": { "compartment": "compartment_70101", "id": "reaction_10509895", "reactome": "R-CEL-156823", "name": "Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509886", "species_10509891" ], "products": [ "species_10509893" ], "modifiers": [], "additional_components": [ "A0A486WX07", "WBGene00002066", "Q20935", "WBGene00018997", "P27639", "WBGene00002083", "O61955", "WBGene00002061", "species_29438", "Q9BKU3", "WBGene00021351", "Q21230", "WBGene00010560", "Q95XR0", "WBGene00021466", "P51403", "WBGene00004471", "Q9NEN6", "WBGene00004475", "Q8WQA8", "WBGene00004489", "Q23312", "WBGene00004476", "O01869", "WBGene00004479", "P49197", "WBGene00004490", "P48156", "WBGene00004477", "Q20206", "WBGene00004480", "Q19877", "WBGene00004492", "Q20228", "WBGene00004478", "P49196", "WBGene00004481", "Q1XFY9", "WBGene00004493", "P46769", "WBGene00004469", "P51404", "WBGene00004482", "P52821", "WBGene00004494", "Q9TXP0", "WBGene00004496", "P48150", "WBGene00004483", "O45499", "WBGene00004495", "Q9N3X2", "WBGene00004473", "Q9XVP0", "WBGene00004484", "Q95Y04", "WBGene00004497", "Q22054", "WBGene00004485", "P90983", "WBGene00004498", "O01692", "WBGene00004486", "P48152", "WBGene00004472", "O18240", "WBGene00004487", "O18650", "WBGene00004488", "P48154", "WBGene00004470", "O17218", "WBGene00004491", "P49041", "WBGene00004474", "Q95QW0", "WBGene00015920", "O01974", "WBGene00001231", "Q94261", "WBGene00019543", "P34339", "WBGene00001209", "Q9XWP7", "WBGene00012738", "P30642", "WBGene00001227", "Q965S8", "WBGene00001232", "O02328", "WBGene00001226", "Q19706", "WBGene00001230", "O61820", "WBGene00001228", "Q18967", "WBGene00001229", "Q9XUP3", "WBGene00001233", "Q9XWI6", "WBGene00001225", "Q9TXU7", "WBGene00019162", "H2L0A8", "WBGene00019157", "Q9U302", "WBGene00003902", "WBGene00004428", "Q27389", "WBGene00004428", "A0A486WX07", "WBGene00002066", "Q20935", "WBGene00018997", "P27639", "WBGene00002083", "O61955", "WBGene00002061", "species_29438", "Q9BKU3", "WBGene00021351", "Q21230", "WBGene00010560", "Q95XR0", "WBGene00021466", "P51403", "WBGene00004471", "Q9NEN6", "WBGene00004475", "Q8WQA8", "WBGene00004489", "Q23312", "WBGene00004476", "O01869", "WBGene00004479", "P49197", "WBGene00004490", "P48156", "WBGene00004477", "Q20206", "WBGene00004480", "Q19877", "WBGene00004492", "Q20228", "WBGene00004478", "P49196", "WBGene00004481", "Q1XFY9", "WBGene00004493", "P46769", "WBGene00004469", "P51404", "WBGene00004482", "P52821", "WBGene00004494", "Q9TXP0", "WBGene00004496", "P48150", "WBGene00004483", "O45499", "WBGene00004495", "Q9N3X2", "WBGene00004473", "Q9XVP0", "WBGene00004484", "Q95Y04", "WBGene00004497", "Q22054", "WBGene00004485", "P90983", "WBGene00004498", "O01692", "WBGene00004486", "P48152", "WBGene00004472", "O18240", "WBGene00004487", "O18650", "WBGene00004488", "P48154", "WBGene00004470", "O17218", "WBGene00004491", "P49041", "WBGene00004474", "Q95QW0", "WBGene00015920", "O01974", "WBGene00001231", "Q94261", "WBGene00019543", "P34339", "WBGene00001209", "Q9XWP7", "WBGene00012738", "P30642", "WBGene00001227", "Q965S8", "WBGene00001232", "O02328", "WBGene00001226", "Q19706", "WBGene00001230", "O61820", "WBGene00001228", "Q18967", "WBGene00001229", "Q9XUP3", "WBGene00001233", "Q9XWI6", "WBGene00001225", "Q9TXU7", "WBGene00019162", "H2L0A8", "WBGene00019157", "Q9U302", "WBGene00003902" ] }, "reaction_10509899": { "compartment": "compartment_70101", "id": "reaction_10509899", "reactome": "R-CEL-156826", "name": "Dissociation of L13a from the 60s ribosomal subunit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10505970" ], "products": [ "species_10509897", "species_10505768" ], "modifiers": [], "additional_components": [ "P91914", "WBGene00004441", "Q19869", "WBGene00004440", "O01868", "WBGene00004436", "P48162", "WBGene00004438", "P52819", "WBGene00004434", "P48158", "WBGene00004435", "Q09533", "WBGene00004421", "P34334", "WBGene00004433", "O02639", "WBGene00004431", "Q95Y90", "WBGene00004420", "O44480", "WBGene00004432", "Q22716", "WBGene00004446", "Q9U332", "WBGene00004445", "Q9XWS4", "WBGene00004444", "P52814", "WBGene00004453", "O45226", "WBGene00004443", "Q21930", "WBGene00004442", "P48166", "WBGene00004454", "Q9BKU5", "WBGene00021350", "P50880", "WBGene00004414", "P61866", "WBGene00004424", "O17570", "WBGene00004452", "Q19162", "WBGene00004423", "Q9U2A8", "WBGene00004456", "Q9N4I4", "WBGene00004412", "O62388", "WBGene00012179", "O01504", "WBGene00016493", "P49181", "WBGene00004450", "P91913", "WBGene00004409", "P49180", "WBGene00004447", "Q93572", "WBGene00004408", "P34662", "WBGene00004449", "Q9XVF7", "WBGene00004413", "O45946", "WBGene00004430", "Q966C6", "WBGene00004419", "Q9BL19", "WBGene00004429", "O01802", "WBGene00004418", "P91374", "WBGene00004427", "P47991", "WBGene00004417", "Q9XVE9", "WBGene00004426", "P49405", "WBGene00004416", "Q27389", "WBGene00004428", "P37165", "WBGene00006725", "P91128", "WBGene00004425", "O02056", "WBGene00004415", "P91914", "WBGene00004441", "Q19869", "WBGene00004440", "O01868", "WBGene00004436", "P48162", "WBGene00004438", "P52819", "WBGene00004434", "P48158", "WBGene00004435", "Q09533", "WBGene00004421", "P34334", "WBGene00004433", "O02639", "WBGene00004431", "Q95Y90", "WBGene00004420", "O44480", "WBGene00004432", "Q22716", "WBGene00004446", "Q9U332", "WBGene00004445", "Q9XWS4", "WBGene00004444", "P52814", "WBGene00004453", "O45226", "WBGene00004443", "Q21930", "WBGene00004442", "P48166", "WBGene00004454", "Q9BKU5", "WBGene00021350", "P50880", "WBGene00004414", "P61866", "WBGene00004424", "O17570", "WBGene00004452", "Q19162", "WBGene00004423", "Q9U2A8", "WBGene00004456", "Q9N4I4", "WBGene00004412", "O62388", "WBGene00012179", "O01504", "WBGene00016493", "P49181", "WBGene00004450", "P91913", "WBGene00004409", "P49180", "WBGene00004447", "Q93572", "WBGene00004408", "P34662", "WBGene00004449", "Q9XVF7", "WBGene00004413", "O45946", "WBGene00004430", "Q966C6", "WBGene00004419", "Q9BL19", "WBGene00004429", "O01802", "WBGene00004418", "P91374", "WBGene00004427", "P47991", "WBGene00004417", "Q9XVE9", "WBGene00004426", "P49405", "WBGene00004416", "P37165", "WBGene00006725", "P91128", "WBGene00004425", "O02056", "WBGene00004415", "WBGene00004428" ] }, "reaction_10550786": { "compartment": "compartment_70101", "id": "reaction_10550786", "reactome": "R-CEL-5228992", "name": "ROCK1,ROCK2 are activated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10521951" ], "products": [ "species_10550784" ], "modifiers": [], "additional_components": [ "Q22038", "WBGene00004357", "species_29438", "P92199", "WBGene00002694", "Q21025", "WBGene00019087", "Q9XVH4", "WBGene00019087", "species_114632", "Q22038", "WBGene00004357", "species_29438", "P92199", "WBGene00002694", "Q21025", "WBGene00019087", "Q9XVH4", "WBGene00019087" ] }, "reaction_10550628": { "compartment": "compartment_876", "id": "reaction_10550628", "reactome": "R-CEL-5218812", "name": "FYN phosphorylates PAK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10550625" ], "products": [ "species_29370", "species_10550576" ], "modifiers": [ [ "species_10550625", "catalyst" ] ], "additional_components": [ "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "G5EGT9", "WBGene00003007", "A0A1I6CMA1", "WBGene00020678", "Q95PX0", "WBGene00006410", "Q05062", "WBGene00000390", "species_29438", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "G5EGT9", "WBGene00003007", "A0A1I6CMA1", "WBGene00020678", "Q95PX0", "WBGene00006410", "Q05062", "WBGene00000390", "species_29438", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "G5EGT9", "WBGene00003007", "A0A1I6CMA1", "WBGene00020678", "Q95PX0", "WBGene00006410", "Q05062", "WBGene00000390", "species_29438", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911" ] }, "reaction_10550693": { "compartment": "compartment_70101", "id": "reaction_10550693", "reactome": "R-CEL-5218916", "name": "p-MAPK2/3 phosphorylates HSP27", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10550685", "species_113592" ], "products": [ "species_10523755", "species_29370", "species_10550690" ], "modifiers": [ [ "species_10512646", "catalyst" ] ], "additional_components": [ "P0DM41", "WBGene00000063", "P0DM42", "WBGene00000065", "P10984", "WBGene00000064", "P10986", "WBGene00000066", "species_29358", "Q17849", "WBGene00002023", "P0DM41", "WBGene00000063", "P0DM42", "WBGene00000065", "P10984", "WBGene00000064", "P10986", "WBGene00000066", "species_29358", "WBGene00002023", "Q21360", "WBGene00010681", "Q965G5", "WBGene00007007" ] }, "reaction_10550665": { "compartment": "compartment_876", "id": "reaction_10550665", "reactome": "R-CEL-5218832", "name": "CDC42:GTP binds PAK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10550663", "species_10512279" ], "products": [ "species_10550636" ], "modifiers": [], "additional_components": [ "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "G5EGT9", "WBGene00003007", "A0A1I6CMA1", "WBGene00020678", "Q95PX0", "WBGene00006410", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "Q05062", "WBGene00000390", "species_29438", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "G5EGT9", "WBGene00003007", "A0A1I6CMA1", "WBGene00020678", "Q95PX0", "WBGene00006410", "Q05062", "WBGene00000390", "species_29438", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911" ] }, "reaction_10550667": { "compartment": "compartment_876", "id": "reaction_10550667", "reactome": "R-CEL-5218847", "name": "PAK2 binds NCK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10520680", "species_10550562" ], "products": [ "species_10550663" ], "modifiers": [], "additional_components": [ "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "G5EGT9", "WBGene00003007", "A0A1I6CMA1", "WBGene00020678", "Q95PX0", "WBGene00006410", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "G5EGT9", "WBGene00003007", "A0A1I6CMA1", "WBGene00020678", "Q95PX0", "WBGene00006410", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911" ] }, "reaction_10550639": { "compartment": "compartment_876", "id": "reaction_10550639", "reactome": "R-CEL-5218814", "name": "PAK2 autophorylates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10550636", "species_113592" ], "products": [ "species_29370", "species_10550625" ], "modifiers": [ [ "species_10550636", "catalyst" ] ], "additional_components": [ "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "G5EGT9", "WBGene00003007", "A0A1I6CMA1", "WBGene00020678", "Q95PX0", "WBGene00006410", "Q05062", "WBGene00000390", "species_29438", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "G5EGT9", "WBGene00003007", "A0A1I6CMA1", "WBGene00020678", "Q95PX0", "WBGene00006410", "Q05062", "WBGene00000390", "species_29438", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "G5EGT9", "WBGene00003007", "A0A1I6CMA1", "WBGene00020678", "Q95PX0", "WBGene00006410", "Q05062", "WBGene00000390", "species_29438", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911" ] }, "reaction_10550610": { "compartment": "compartment_70101", "id": "reaction_10550610", "reactome": "R-CEL-5218805", "name": "PKC autophosphorylates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10550592" ], "products": [ "species_10550607", "species_29370" ], "modifiers": [ [ "species_10550592", "catalyst" ] ], "additional_components": [ "Q19266", "WBGene00004034", "P90980", "WBGene00004033", "P34722", "WBGene00006599", "Q19266", "WBGene00004034", "P90980", "WBGene00004033", "P34722", "WBGene00006599", "Q19266", "WBGene00004034", "P90980", "WBGene00004033", "P34722", "WBGene00006599" ] }, "reaction_10550659": { "compartment": "compartment_876", "id": "reaction_10550659", "reactome": "R-CEL-5218823", "name": "PKC phosphorylates sphingosine kinase 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10520872" ], "products": [ "species_29370", "species_10550656" ], "modifiers": [ [ "species_10550630", "catalyst" ] ], "additional_components": [ "WBGene00007918", "WBGene00007918", "species_74016", "species_112275", "Q19266", "WBGene00004034", "P90980", "WBGene00004033", "P34722", "WBGene00006599" ] }, "reaction_10550653": { "compartment": "compartment_876", "id": "reaction_10550653", "reactome": "R-CEL-5218821", "name": "PDK1 phosphorylates PKC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10550650", "species_113592" ], "products": [ "species_29370", "species_10550592" ], "modifiers": [ [ "species_10508528", "catalyst" ] ], "additional_components": [ "P90980", "WBGene00004033", "Q19266", "WBGene00004034", "P34722", "WBGene00006599", "Q19266", "WBGene00004034", "P90980", "WBGene00004033", "P34722", "WBGene00006599", "WBGene00021022" ] }, "reaction_10550579": { "compartment": "compartment_70101", "id": "reaction_10550579", "reactome": "R-CEL-5218804", "name": "p38 MAPK activation by VEGFR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10526151" ], "products": [ "species_29370", "species_10512658" ], "modifiers": [ [ "species_10550576", "catalyst" ] ], "additional_components": [ "Q17446", "WBGene00004055", "Q8MXI4", "WBGene00004056", "species_114632", "Q17446", "WBGene00004055", "Q8MXI4", "WBGene00004056", "species_114632", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "G5EGT9", "WBGene00003007", "A0A1I6CMA1", "WBGene00020678", "Q95PX0", "WBGene00006410", "Q05062", "WBGene00000390", "species_29438", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911" ] }, "reaction_10548788": { "compartment": "compartment_876", "id": "reaction_10548788", "reactome": "R-CEL-3928647", "name": "RHOA:GTP:Mg2+ binds ROCK1,ROCK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10521949", "species_10509488" ], "products": [ "species_10521951" ], "modifiers": [], "additional_components": [ "P92199", "WBGene00002694", "Q21025", "WBGene00019087", "Q9XVH4", "WBGene00019087", "Q22038", "WBGene00004357", "species_29438", "Q22038", "WBGene00004357", "species_29438", "P92199", "WBGene00002694", "Q21025", "WBGene00019087", "Q9XVH4", "WBGene00019087" ] }, "reaction_10550644": { "compartment": "compartment_876", "id": "reaction_10550644", "reactome": "R-CEL-5218819", "name": "VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10550641", "catalyst" ] ], "additional_components": [ "G5EGT9", "WBGene00003007", "A0A1I6CMA1", "WBGene00020678", "G5EDP9", "WBGene00000001", "Q94125", "WBGene00000090" ] }, "reaction_10569044": { "compartment": "compartment_876", "id": "reaction_10569044", "reactome": "R-CEL-8951586", "name": "p-VAV family:PIP3 binds RAC1:GDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10541992", "species_10550646" ], "products": [ "species_10550669" ], "modifiers": [], "additional_components": [ "species_29420", "Q03206", "ced-10", "Q45FX5", "WBGene00006887", "species_179838", "Q45FX5", "WBGene00006887", "species_179838", "species_29420", "Q03206", "ced-10" ] }, "reaction_10551522": { "compartment": "compartment_876", "id": "reaction_10551522", "reactome": "R-CEL-5357445", "name": "PAK1-3 dimer disassociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10551518" ], "products": [ "species_10551520" ], "modifiers": [], "additional_components": [ "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "species_29438", "Q03206", "ced-10", "Q45FX5", "WBGene00006887", "species_179838", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "species_29438", "Q03206", "ced-10", "Q45FX5", "WBGene00006887", "species_179838" ] }, "reaction_10551525": { "compartment": "compartment_876", "id": "reaction_10551525", "reactome": "R-CEL-5357472", "name": "PAK1-3 autophosphorylates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10551520" ], "products": [ "species_10550671", "species_29370", "species_10521284" ], "modifiers": [ [ "species_10520686", "catalyst" ] ], "additional_components": [ "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "species_29438", "Q03206", "ced-10", "Q45FX5", "WBGene00006887", "species_179838", "species_29438", "Q03206", "ced-10", "Q45FX5", "WBGene00006887", "species_179838", "Q17850", "WBGene00003911", "G5EGQ3", "WBGene00003144", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911" ] }, "reaction_10551558": { "compartment": "compartment_876", "id": "reaction_10551558", "reactome": "R-CEL-5357477", "name": "PAK1-3 phosphorylates VE-cadherin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10551551", "species_113592" ], "products": [ "species_29370", "species_10551555" ], "modifiers": [ [ "species_10521284", "catalyst" ] ], "additional_components": [ "Q9U308", "WBGene00002175", "P90947", "WBGene00001978", "Q10953", "WBGene00006943", "Q18825", "WBGene00000238", "O44326", "WBGene00001979", "Q9U308", "WBGene00002175", "P90947", "WBGene00001978", "Q10953", "WBGene00006943", "Q18825", "WBGene00000238", "O44326", "WBGene00001979", "Q17850", "WBGene00003911", "G5EGQ3", "WBGene00003144" ] }, "reaction_10551560": { "compartment": "compartment_876", "id": "reaction_10551560", "reactome": "R-CEL-5357483", "name": "RAC1 binds PAK1-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10550671", "species_10520686" ], "products": [ "species_10551518" ], "modifiers": [], "additional_components": [ "species_29438", "Q03206", "ced-10", "Q45FX5", "WBGene00006887", "species_179838", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "species_29438", "Q03206", "ced-10", "Q45FX5", "WBGene00006887", "species_179838" ] }, "reaction_10515164": { "compartment": "compartment_70101", "id": "reaction_10515164", "reactome": "R-CEL-202111", "name": "AKT1 phosphorylates eNOS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10515154" ], "products": [ "species_29370", "species_10515162" ], "modifiers": [], "additional_components": [ "G4S4W1", "WBGene00016980", "Q17941", "WBGene00000102", "Q9XTG7", "WBGene00000103", "species_74016", "O16305", "WBGene00000552", "P04630", "WBGene00000285", "Q09665", "WBGene00006583", "A0A2C9C3L3", "WBGene00020378", "Q09980", "WBGene00017394", "G5EDZ8", "WBGene00000288", "Q11083", "WBGene00020378", "G5EEG0", "WBGene00000286", "Q18136", "WBGene00006861", "G5EF37", "WBGene00003934", "Q94288", "WBGene00000287", "O02159", "WBGene00020378", "species_71185", "species_216785", "species_73524", "species_113596", "Q18688", "WBGene00000915", "Q9XTG7", "WBGene00000103", "G4S4W1", "WBGene00016980", "Q17941", "WBGene00000102", "species_74016", "Q11083", "WBGene00020378", "P04630", "WBGene00000285", "G5EF37", "WBGene00003934", "A0A2C9C3L3", "WBGene00020378", "Q18136", "WBGene00006861", "Q09665", "WBGene00006583", "O02159", "WBGene00020378", "G5EDZ8", "WBGene00000288", "Q94288", "WBGene00000287", "Q09980", "WBGene00017394", "O16305", "WBGene00000552", "G5EEG0", "WBGene00000286", "Q18688", "WBGene00000915", "species_71185", "species_216785", "species_73524", "species_113596", "species_29870" ] }, "reaction_10535150": { "compartment": "compartment_70101", "id": "reaction_10535150", "reactome": "R-CEL-1497784", "name": "The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29870", "species_10515162" ], "products": [ "species_10515166" ], "modifiers": [], "additional_components": [ "Q9XTG7", "WBGene00000103", "G4S4W1", "WBGene00016980", "Q17941", "WBGene00000102", "species_74016", "Q11083", "WBGene00020378", "P04630", "WBGene00000285", "G5EF37", "WBGene00003934", "A0A2C9C3L3", "WBGene00020378", "Q18136", "WBGene00006861", "Q09665", "WBGene00006583", "O02159", "WBGene00020378", "G5EDZ8", "WBGene00000288", "Q94288", "WBGene00000287", "Q09980", "WBGene00017394", "O16305", "WBGene00000552", "G5EEG0", "WBGene00000286", "Q18688", "WBGene00000915", "species_71185", "species_216785", "species_73524", "species_113596", "species_29870", "Q9XTG7", "WBGene00000103", "G4S4W1", "WBGene00016980", "Q17941", "WBGene00000102", "species_74016", "Q11083", "WBGene00020378", "P04630", "WBGene00000285", "G5EF37", "WBGene00003934", "A0A2C9C3L3", "WBGene00020378", "Q18136", "WBGene00006861", "Q09665", "WBGene00006583", "O02159", "WBGene00020378", "G5EDZ8", "WBGene00000288", "Q94288", "WBGene00000287", "Q09980", "WBGene00017394", "O16305", "WBGene00000552", "G5EEG0", "WBGene00000286", "Q18688", "WBGene00000915", "species_71185", "species_216785", "species_73524", "species_113596", "species_29870" ] }, "reaction_10550679": { "compartment": "compartment_70101", "id": "reaction_10550679", "reactome": "R-CEL-5218854", "name": "p-Y420-FYN is phosphorylated on S21", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10550614" ], "products": [ "species_29370", "species_10550562" ], "modifiers": [ [ "species_10550676", "catalyst" ] ], "additional_components": [ "G5EGT9", "WBGene00003007", "A0A1I6CMA1", "WBGene00020678", "Q95PX0", "WBGene00006410", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "G5EGT9", "WBGene00003007", "A0A1I6CMA1", "WBGene00020678", "Q95PX0", "WBGene00006410" ] }, "reaction_10550617": { "compartment": "compartment_876", "id": "reaction_10550617", "reactome": "R-CEL-5218806", "name": "FYN autophosphorylates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10550612" ], "products": [ "species_29370", "species_10550614" ], "modifiers": [ [ "species_10550612", "catalyst" ] ], "additional_components": [ "G5EGT9", "WBGene00003007", "A0A1I6CMA1", "WBGene00020678", "Q95PX0", "WBGene00006410", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "G5EGT9", "WBGene00003007", "A0A1I6CMA1", "WBGene00020678", "Q95PX0", "WBGene00006410", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "G5EGT9", "WBGene00003007", "A0A1I6CMA1", "WBGene00020678", "Q95PX0", "WBGene00006410", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635" ] }, "reaction_10565172": { "compartment": "compartment_70101", "id": "reaction_10565172", "reactome": "R-CEL-8851933", "name": "MET phosphorylates GAB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10565169" ], "products": [ "species_29370", "species_10543879" ], "modifiers": [ [ "species_10565169", "catalyst" ] ], "additional_components": [ "Q9XVQ7", "WBGene00008711", "G5EDJ4", "WBGene00004928", "P29355", "WBGene00004774", "G5EDJ4", "WBGene00004928", "Q9XVQ7", "WBGene00008711", "P29355", "WBGene00004774", "Q9XVQ7", "WBGene00008711", "G5EDJ4", "WBGene00004928", "P29355", "WBGene00004774" ] }, "reaction_10565174": { "compartment": "compartment_70101", "id": "reaction_10565174", "reactome": "R-CEL-8851954", "name": "Phosphorylated GAB1 recruits PI3K to MET", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10506892", "species_10543879" ], "products": [ "species_10543881" ], "modifiers": [], "additional_components": [ "G5EDP9", "WBGene00000001", "Q94125", "WBGene00000090", "G5EDJ4", "WBGene00004928", "Q9XVQ7", "WBGene00008711", "P29355", "WBGene00004774", "G5EDJ4", "WBGene00004928", "Q9XVQ7", "WBGene00008711", "P29355", "WBGene00004774", "G5EDP9", "WBGene00000001", "Q94125", "WBGene00000090" ] }, "reaction_10565177": { "compartment": "compartment_70101", "id": "reaction_10565177", "reactome": "R-CEL-8852019", "name": "MET bound PI3K generates PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10543881", "catalyst" ] ], "additional_components": [ "G5EDJ4", "WBGene00004928", "Q9XVQ7", "WBGene00008711", "P29355", "WBGene00004774", "G5EDP9", "WBGene00000001", "Q94125", "WBGene00000090" ] }, "reaction_10532954": { "compartment": "compartment_876", "id": "reaction_10532954", "reactome": "R-CEL-1306972", "name": "RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10512175", "species_29438" ], "products": [ "species_29420", "species_10511481" ], "modifiers": [ [ "species_10532951", "catalyst" ] ], "additional_components": [ "species_29420", "P22981", "WBGene00002335", "species_29438", "P22981", "WBGene00002335", "P29355", "WBGene00004774", "Q9N5D3", "WBGene00004947" ] }, "reaction_10532961": { "compartment": "compartment_876", "id": "reaction_10532961", "reactome": "R-CEL-1306979", "name": "PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10532958", "catalyst" ] ], "additional_components": [ "G5EDP9", "WBGene00000001", "Q94125", "WBGene00000090" ] }, "reaction_10532945": { "compartment": "compartment_876", "id": "reaction_10532945", "reactome": "R-CEL-1306957", "name": "PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10532942", "catalyst" ] ], "additional_components": [ "Q94125", "WBGene00000090", "G5EDP9", "WBGene00000001", "P29355", "WBGene00004774", "G5EDJ4", "WBGene00004928" ] }, "reaction_10532947": { "compartment": "compartment_70101", "id": "reaction_10532947", "reactome": "R-CEL-1306965", "name": "Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR.", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10506892", "species_10532938" ], "products": [ "species_10532942" ], "modifiers": [], "additional_components": [ "G5EDP9", "WBGene00000001", "Q94125", "WBGene00000090", "P29355", "WBGene00004774", "G5EDJ4", "WBGene00004928", "Q94125", "WBGene00000090", "G5EDP9", "WBGene00000001", "P29355", "WBGene00004774", "G5EDJ4", "WBGene00004928" ] }, "reaction_10532507": { "compartment": "compartment_876", "id": "reaction_10532507", "reactome": "R-CEL-1250462", "name": "PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10532504", "catalyst" ] ], "additional_components": [ "G5EDP9", "WBGene00000001", "Q94125", "WBGene00000090" ] }, "reaction_10572739": { "compartment": "compartment_70101", "id": "reaction_10572739", "reactome": "R-CEL-9652264", "name": "ERBB2 binds TKIs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9652360", "species_10538183" ], "products": [ "species_10572737" ], "modifiers": [], "additional_components": [ "P24348", "WBGene00002299", "O02108", "WBGene00021097", "Q18688", "WBGene00000915", "O02108", "WBGene00021097", "Q18688", "WBGene00000915", "P24348", "WBGene00002299" ] }, "reaction_10538193": { "compartment": "compartment_70101", "id": "reaction_10538193", "reactome": "R-CEL-1918095", "name": "CUL5 mediates ubiquitination of ERBB2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502375", "species_10538183" ], "products": [ "species_10538190" ], "modifiers": [ [ "species_10530998", "catalyst" ] ], "additional_components": [ "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "P24348", "WBGene00002299", "O02108", "WBGene00021097", "Q18688", "WBGene00000915", "P24348", "WBGene00002299", "O02108", "WBGene00021097", "Q18688", "WBGene00000915", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "WBGene00000840" ] }, "reaction_10538188": { "compartment": "compartment_70101", "id": "reaction_10538188", "reactome": "R-CEL-1918092", "name": "CHIP (STUB1) mediates ubiquitination of ERBB2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502375", "species_10538183" ], "products": [ "species_10538185" ], "modifiers": [ [ "species_10530864", "catalyst" ] ], "additional_components": [ "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "P24348", "WBGene00002299", "O02108", "WBGene00021097", "Q18688", "WBGene00000915", "P24348", "WBGene00002299", "O02108", "WBGene00021097", "Q18688", "WBGene00000915", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "WBGene00000500" ] }, "reaction_10512456": { "compartment": "compartment_984", "id": "reaction_10512456", "reactome": "R-CEL-186785", "name": "PDGF-AA clevage by Furin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10512452" ], "products": [ "species_10512392", "species_10512454" ], "modifiers": [ [ "species_10510315", "catalyst" ] ], "additional_components": [ "Q9N413", "WBGene00004249", "Q9N413", "WBGene00004249", "WBGene00004249", "WBGene00002232" ] }, "reaction_10520337": { "compartment": "compartment_70101", "id": "reaction_10520337", "reactome": "R-CEL-382058", "name": "Nck binds to the active PDGF receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10518510", "species_10512404" ], "products": [ "species_10520335" ], "modifiers": [], "additional_components": [ "WBGene00006410", "Q9N413", "WBGene00004249", "G5EGT9", "WBGene00003007", "A0A1I6CMA1", "WBGene00020678", "Q9N413", "WBGene00004249", "G5EGT9", "WBGene00003007", "A0A1I6CMA1", "WBGene00020678", "Q95PX0", "WBGene00006410" ] }, "reaction_10512466": { "compartment": "compartment_70101", "id": "reaction_10512466", "reactome": "R-CEL-186800", "name": "PI3K catalyses the phosphorylation of PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10512444", "catalyst" ] ], "additional_components": [ "Q9N413", "WBGene00004249", "G5EGT9", "WBGene00003007", "A0A1I6CMA1", "WBGene00020678", "G5EDP9", "WBGene00000001", "Q94125", "WBGene00000090" ] }, "reaction_10535202": { "compartment": "compartment_876", "id": "reaction_10535202", "reactome": "R-CEL-1524186", "name": "Phosphorylation of PLCgamma by PDGFR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10512408" ], "products": [ "species_10535197", "species_29370" ], "modifiers": [ [ "species_10512408", "catalyst" ] ], "additional_components": [ "Q9N413", "WBGene00004249", "G5EGT9", "WBGene00003007", "A0A1I6CMA1", "WBGene00020678", "Q22070", "WBGene00004038", "Q22070", "WBGene00004038", "Q9N413", "WBGene00004249", "G5EGT9", "WBGene00003007", "A0A1I6CMA1", "WBGene00020678", "Q9N413", "WBGene00004249", "G5EGT9", "WBGene00003007", "A0A1I6CMA1", "WBGene00020678", "Q22070", "WBGene00004038" ] }, "reaction_10519939": { "compartment": "compartment_70101", "id": "reaction_10519939", "reactome": "R-CEL-380782", "name": "STAT binds to the active receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10519935", "species_10512404" ], "products": [ "species_10519937" ], "modifiers": [], "additional_components": [ "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9N413", "WBGene00004249", "G5EGT9", "WBGene00003007", "A0A1I6CMA1", "WBGene00020678", "Q9N413", "WBGene00004249", "G5EGT9", "WBGene00003007", "A0A1I6CMA1", "WBGene00020678", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251" ] }, "reaction_10512484": { "compartment": "compartment_876", "id": "reaction_10512484", "reactome": "R-CEL-186819", "name": "SH2 domain of Src binds to the active receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10512404", "species_10512480" ], "products": [ "species_10512482" ], "modifiers": [], "additional_components": [ "Q9N413", "WBGene00004249", "G5EGT9", "WBGene00003007", "A0A1I6CMA1", "WBGene00020678", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q9N413", "WBGene00004249", "G5EGT9", "WBGene00003007", "A0A1I6CMA1", "WBGene00020678" ] }, "reaction_10512488": { "compartment": "compartment_70101", "id": "reaction_10512488", "reactome": "R-CEL-186826", "name": "GRB2:SOS1 complex binds to the active receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10506878", "species_10512404" ], "products": [ "species_10512486" ], "modifiers": [], "additional_components": [ "P29355", "WBGene00004774", "Q9N5D3", "WBGene00004947", "Q9N413", "WBGene00004249", "G5EGT9", "WBGene00003007", "A0A1I6CMA1", "WBGene00020678", "Q9N413", "WBGene00004249", "G5EGT9", "WBGene00003007", "A0A1I6CMA1", "WBGene00020678", "P29355", "WBGene00004774", "Q9N5D3", "WBGene00004947" ] }, "reaction_10512410": { "compartment": "compartment_876", "id": "reaction_10512410", "reactome": "R-CEL-186765", "name": "PLC-gamma binds to the active receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10512406", "species_10512404" ], "products": [ "species_10512408" ], "modifiers": [], "additional_components": [ "WBGene00004038", "Q9N413", "WBGene00004249", "G5EGT9", "WBGene00003007", "A0A1I6CMA1", "WBGene00020678", "Q9N413", "WBGene00004249", "G5EGT9", "WBGene00003007", "A0A1I6CMA1", "WBGene00020678", "Q22070", "WBGene00004038" ] }, "reaction_10512491": { "compartment": "compartment_70101", "id": "reaction_10512491", "reactome": "R-CEL-186834", "name": "SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10512175", "species_29438" ], "products": [ "species_29420", "species_10511481" ], "modifiers": [ [ "species_10512486", "catalyst" ] ], "additional_components": [ "species_29420", "P22981", "WBGene00002335", "species_29438", "P22981", "WBGene00002335", "Q9N413", "WBGene00004249", "G5EGT9", "WBGene00003007", "A0A1I6CMA1", "WBGene00020678", "P29355", "WBGene00004774", "Q9N5D3", "WBGene00004947" ] }, "reaction_10519901": { "compartment": "compartment_70101", "id": "reaction_10519901", "reactome": "R-CEL-380780", "name": "Activation of Src", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10512482" ], "products": [ "species_10519898", "species_29370" ], "modifiers": [ [ "species_10512482", "catalyst" ] ], "additional_components": [ "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q9N413", "WBGene00004249", "G5EGT9", "WBGene00003007", "A0A1I6CMA1", "WBGene00020678", "Q9N413", "WBGene00004249", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "G5EGT9", "WBGene00003007", "A0A1I6CMA1", "WBGene00020678", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q9N413", "WBGene00004249", "G5EGT9", "WBGene00003007", "A0A1I6CMA1", "WBGene00020678" ] }, "reaction_10512446": { "compartment": "compartment_70101", "id": "reaction_10512446", "reactome": "R-CEL-186780", "name": "PI3-kinase binds to the active receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10506892", "species_10512404" ], "products": [ "species_10512444" ], "modifiers": [], "additional_components": [ "G5EDP9", "WBGene00000001", "Q94125", "WBGene00000090", "Q9N413", "WBGene00004249", "G5EGT9", "WBGene00003007", "A0A1I6CMA1", "WBGene00020678", "Q9N413", "WBGene00004249", "G5EGT9", "WBGene00003007", "A0A1I6CMA1", "WBGene00020678", "G5EDP9", "WBGene00000001", "Q94125", "WBGene00000090" ] }, "reaction_10535199": { "compartment": "compartment_876", "id": "reaction_10535199", "reactome": "R-CEL-1524182", "name": "Activated PLC gamma dissociates from the PDGF receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10535197" ], "products": [ "species_10512404", "species_10515233" ], "modifiers": [], "additional_components": [ "Q22070", "WBGene00004038", "Q9N413", "WBGene00004249", "G5EGT9", "WBGene00003007", "A0A1I6CMA1", "WBGene00020678", "Q9N413", "WBGene00004249", "G5EGT9", "WBGene00003007", "A0A1I6CMA1", "WBGene00020678", "WBGene00004038" ] }, "reaction_10520319": { "compartment": "compartment_70101", "id": "reaction_10520319", "reactome": "R-CEL-382056", "name": "Crk binds to the active PDGF receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10520269", "species_10512404" ], "products": [ "species_10520271" ], "modifiers": [], "additional_components": [ "Q9NHC3", "WBGene00000416", "Q95XA9", "WBGene00021238", "Q9N413", "WBGene00004249", "G5EGT9", "WBGene00003007", "A0A1I6CMA1", "WBGene00020678", "Q9N413", "WBGene00004249", "G5EGT9", "WBGene00003007", "A0A1I6CMA1", "WBGene00020678", "Q9NHC3", "WBGene00000416", "Q95XA9", "WBGene00021238" ] }, "reaction_10573065": { "compartment": "compartment_876", "id": "reaction_10573065", "reactome": "R-CEL-9674093", "name": "PDGFRs bind type I TKI", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10520554", "species_9674075" ], "products": [ "species_10520559" ], "modifiers": [], "additional_components": [ "Q9N413", "WBGene00004249", "A0A1I6CMA1", "WBGene00020678", "G5EGT9", "WBGene00003007", "Q9N413", "WBGene00004249", "A0A1I6CMA1", "WBGene00020678", "G5EGT9", "WBGene00003007" ] }, "reaction_10573067": { "compartment": "compartment_876", "id": "reaction_10573067", "reactome": "R-CEL-9674095", "name": "PDGFRs bind type II TKI", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9674079", "species_10512424" ], "products": [ "species_10512436" ], "modifiers": [], "additional_components": [ "A0A1I6CMA1", "WBGene00020678", "G5EGT9", "WBGene00003007", "A0A1I6CMA1", "WBGene00020678", "G5EGT9", "WBGene00003007" ] }, "reaction_10520333": { "compartment": "compartment_984", "id": "reaction_10520333", "reactome": "R-CEL-382057", "name": "Release of novel PDGFs as latent factors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10520321" ], "products": [ "species_10520331" ], "modifiers": [], "additional_components": [ "Q9N413", "WBGene00004249", "Q9N413", "WBGene00004249" ] }, "reaction_10566190": { "compartment": "compartment_984", "id": "reaction_10566190", "reactome": "R-CEL-8865275", "name": "PDGF-BB clevage by Furin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10520297" ], "products": [ "species_10512398", "species_10566186" ], "modifiers": [ [ "species_10510315", "catalyst" ] ], "additional_components": [ "Q9N413", "WBGene00004249", "Q9N413", "WBGene00004249", "WBGene00004249", "WBGene00002232" ] }, "reaction_10512463": { "compartment": "compartment_70101", "id": "reaction_10512463", "reactome": "R-CEL-186786", "name": "Autophosphorylation of PDGF beta receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10512458", "species_113592" ], "products": [ "species_10512460", "species_29370" ], "modifiers": [ [ "species_10512458", "catalyst" ] ], "additional_components": [ "A0A1I6CMA1", "WBGene00020678", "G5EGT9", "WBGene00003007", "Q9N413", "WBGene00004249", "G5EGT9", "WBGene00003007", "A0A1I6CMA1", "WBGene00020678", "Q9N413", "WBGene00004249", "A0A1I6CMA1", "WBGene00020678", "G5EGT9", "WBGene00003007", "Q9N413", "WBGene00004249" ] }, "reaction_10566192": { "compartment": "compartment_984", "id": "reaction_10566192", "reactome": "R-CEL-8865276", "name": "PDGF-AB clevage by Furin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10520299" ], "products": [ "species_10566186", "species_10512454", "species_10512400" ], "modifiers": [ [ "species_10510315", "catalyst" ] ], "additional_components": [ "Q9N413", "WBGene00004249", "WBGene00004249", "WBGene00004249", "Q9N413", "WBGene00004249", "WBGene00002232" ] }, "reaction_10520561": { "compartment": "compartment_70101", "id": "reaction_10520561", "reactome": "R-CEL-389083", "name": "Autophosphorylation of PDGF alpha receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10520554", "species_113592" ], "products": [ "species_10520556", "species_29370" ], "modifiers": [ [ "species_10520554", "catalyst" ], [ "species_10520559", "inhibitor" ] ], "additional_components": [ "Q9N413", "WBGene00004249", "A0A1I6CMA1", "WBGene00020678", "G5EGT9", "WBGene00003007", "Q9N413", "WBGene00004249", "G5EGT9", "WBGene00003007", "A0A1I6CMA1", "WBGene00020678", "Q9N413", "WBGene00004249", "A0A1I6CMA1", "WBGene00020678", "G5EGT9", "WBGene00003007", "Q9N413", "WBGene00004249", "A0A1I6CMA1", "WBGene00020678", "G5EGT9", "WBGene00003007" ] }, "reaction_10520311": { "compartment": "compartment_20699", "id": "reaction_10520311", "reactome": "R-CEL-382053", "name": "Translocation of PDGF from ER to Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10520293" ], "products": [ "species_10520309" ], "modifiers": [], "additional_components": [ "Q9N413", "WBGene00004249", "Q9N413", "WBGene00004249" ] }, "reaction_10512440": { "compartment": "compartment_876", "id": "reaction_10512440", "reactome": "R-CEL-186773", "name": "PDGF dimer binds two receptors simultaneously", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10512424", "species_10512402" ], "products": [ "species_10512434" ], "modifiers": [ [ "species_10512438", "inhibitor" ], [ "species_10512436", "inhibitor" ] ], "additional_components": [ "A0A1I6CMA1", "WBGene00020678", "G5EGT9", "WBGene00003007", "Q9N413", "WBGene00004249", "A0A1I6CMA1", "WBGene00020678", "G5EGT9", "WBGene00003007", "Q9N413", "WBGene00004249", "A0A1I6CMA1", "WBGene00020678", "G5EGT9", "WBGene00003007", "A0A1I6CMA1", "WBGene00020678", "G5EGT9", "WBGene00003007" ] }, "reaction_10520571": { "compartment": "compartment_70101", "id": "reaction_10520571", "reactome": "R-CEL-389086", "name": "Autophosphorylation of PDGF alpha/beta receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10520566" ], "products": [ "species_29370", "species_10520568" ], "modifiers": [ [ "species_10520566", "catalyst" ] ], "additional_components": [ "Q9N413", "WBGene00004249", "A0A1I6CMA1", "WBGene00020678", "G5EGT9", "WBGene00003007", "Q9N413", "WBGene00004249", "G5EGT9", "WBGene00003007", "A0A1I6CMA1", "WBGene00020678", "Q9N413", "WBGene00004249", "A0A1I6CMA1", "WBGene00020678", "G5EGT9", "WBGene00003007" ] }, "reaction_10520317": { "compartment": "compartment_984", "id": "reaction_10520317", "reactome": "R-CEL-382054", "name": "PDGF binds to extracellular matrix proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10512396", "species_10520313" ], "products": [ "species_10520315" ], "modifiers": [], "additional_components": [ "WBGene00004249", "Q9N4U2", "WBGene00000647", "O76368", "WBGene00000674", "Q09457", "WBGene00000251", "P17140", "WBGene00002280", "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689", "CHEBI:18137", "CHEBI:17421", "Q9N4U2", "WBGene00000647", "O76368", "WBGene00000674", "Q09457", "WBGene00000251", "P17140", "WBGene00002280", "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689", "CHEBI:18137", "CHEBI:17421", "Q9N413", "WBGene00004249" ] }, "reaction_10533137": { "compartment": "compartment_876", "id": "reaction_10533137", "reactome": "R-CEL-1433423", "name": "PTP-RO interacts with p-c-Kit complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10533133", "species_10516216" ], "products": [ "species_10533135" ], "modifiers": [], "additional_components": [ "G5EC69", "WBGene00011755", "Q20019", "WBGene00011755", "Q21522", "WBGene00011755", "A0A1I6CMA1", "WBGene00020678", "G5EGT9", "WBGene00003007", "A0A1I6CMA1", "WBGene00020678", "G5EGT9", "WBGene00003007", "G5EC69", "WBGene00011755", "Q20019", "WBGene00011755", "Q21522", "WBGene00011755" ] }, "reaction_10573104": { "compartment": "compartment_876", "id": "reaction_10573104", "reactome": "R-CEL-9681375", "name": "KIT binds ripretinib", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10516216", "species_9674322" ], "products": [ "species_10573102" ], "modifiers": [], "additional_components": [ "A0A1I6CMA1", "WBGene00020678", "G5EGT9", "WBGene00003007", "A0A1I6CMA1", "WBGene00020678", "G5EGT9", "WBGene00003007" ] }, "reaction_10533140": { "compartment": "compartment_876", "id": "reaction_10533140", "reactome": "R-CEL-1433471", "name": "Activation of RAS by p-KIT bound SOS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10512175", "species_29438" ], "products": [ "species_29420", "species_10511481" ], "modifiers": [ [ "species_10516244", "catalyst" ] ], "additional_components": [ "species_29420", "P22981", "WBGene00002335", "species_29438", "P22981", "WBGene00002335", "A0A1I6CMA1", "WBGene00020678", "G5EGT9", "WBGene00003007", "P29355", "WBGene00004774", "Q9N5D3", "WBGene00004947" ] }, "reaction_10533155": { "compartment": "compartment_876", "id": "reaction_10533155", "reactome": "R-CEL-1433508", "name": "PKC alpha interacts with and phosphorylates KIT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10516216", "species_10509044" ], "products": [ "species_29370", "species_10533152" ], "modifiers": [ [ "species_10509044", "catalyst" ] ], "additional_components": [ "A0A1I6CMA1", "WBGene00020678", "G5EGT9", "WBGene00003007", "WBGene00004033", "P90980", "WBGene00004033", "A0A1I6CMA1", "WBGene00020678", "G5EGT9", "WBGene00003007", "WBGene00004033" ] }, "reaction_10516248": { "compartment": "compartment_876", "id": "reaction_10516248", "reactome": "R-CEL-205244", "name": "Recruitment of CBL to KIT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10512267", "species_10516244" ], "products": [ "species_10516246" ], "modifiers": [], "additional_components": [ "WBGene00004829", "A0A1I6CMA1", "WBGene00020678", "G5EGT9", "WBGene00003007", "P29355", "WBGene00004774", "Q9N5D3", "WBGene00004947", "A0A1I6CMA1", "WBGene00020678", "G5EGT9", "WBGene00003007", "P29355", "WBGene00004774", "Q9N5D3", "WBGene00004947", "Q19019", "WBGene00004829" ] }, "reaction_10533180": { "compartment": "compartment_876", "id": "reaction_10533180", "reactome": "R-CEL-1433514", "name": "Synthesis of PIP3 from PIP2 by PI3K", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10533177", "catalyst" ] ], "additional_components": [ "A0A1I6CMA1", "WBGene00020678", "G5EGT9", "WBGene00003007", "Q9N3S5", "WBGene00021635", "G5EE56", "WBGene00005077", "P29355", "WBGene00004774", "G5EDJ4", "WBGene00004928", "G5EDP9", "WBGene00000001", "Q94125", "WBGene00000090" ] }, "reaction_10533119": { "compartment": "compartment_70101", "id": "reaction_10533119", "reactome": "R-CEL-1433415", "name": "Activation of RAC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10520575", "species_29438" ], "products": [ "species_29420", "species_10509457" ], "modifiers": [ [ "species_10533116", "catalyst" ] ], "additional_components": [ "species_29420", "Q03206", "ced-10", "species_29438", "Q03206", "ced-10", "Q45FX5", "WBGene00006887", "species_179838" ] }, "reaction_10573054": { "compartment": "compartment_876", "id": "reaction_10573054", "reactome": "R-CEL-9669854", "name": "KIT binds type II TKIs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9669722", "species_10516216" ], "products": [ "species_10573052" ], "modifiers": [], "additional_components": [ "A0A1I6CMA1", "WBGene00020678", "G5EGT9", "WBGene00003007", "A0A1I6CMA1", "WBGene00020678", "G5EGT9", "WBGene00003007" ] }, "reaction_10506848": { "compartment": "compartment_17940", "id": "reaction_10506848", "reactome": "R-CEL-74723", "name": "Endosome acidification", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106" ], "products": [ "species_74722" ], "modifiers": [ [ "species_10506845", "catalyst" ] ], "additional_components": [ "G5EGP4", "WBGene00006915", "P30628", "WBGene00006768", "B2MZD0", "WBGene00006916", "G5EEK9", "WBGene00006914", "C0HLB3", "WBGene00006911", "C0HLB4", "WBGene00006912", "G5EDB8", "WBGene00006913", "Q95YD5", "WBGene00016258", "Q20591", "WBGene00009882", "Q9XXU9", "WBGene00006920", "Q22494", "WBGene00020507", "Q23680", "WBGene00006918", "P34462", "WBGene00010130", "Q9XW92", "WBGene00013025", "Q19626", "WBGene00006921", "Q9N5A0", "WBGene00004959", "Q95X44", "WBGene00006917", "P91303", "WBGene00006919", "Q9TYW1", "WBGene00021952" ] }, "reaction_10506866": { "compartment": "compartment_876", "id": "reaction_10506866", "reactome": "R-CEL-74734", "name": "Re-integration of insulin receptor into plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10506864" ], "products": [ "species_10506690" ], "modifiers": [], "additional_components": [ "Q968Y9", "WBGene00000898", "Q968Y9", "WBGene00000898" ] }, "reaction_10551244": { "compartment": "compartment_171062", "id": "reaction_10551244", "reactome": "R-CEL-5252133", "name": "ATP6AP1 binds V-ATPase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10506843", "species_10506838" ], "products": [ "species_10506845" ], "modifiers": [], "additional_components": [ "WBGene00021952", "G5EGP4", "WBGene00006915", "P30628", "WBGene00006768", "B2MZD0", "WBGene00006916", "G5EEK9", "WBGene00006914", "C0HLB3", "WBGene00006911", "C0HLB4", "WBGene00006912", "G5EDB8", "WBGene00006913", "Q95YD5", "WBGene00016258", "Q20591", "WBGene00009882", "Q9XXU9", "WBGene00006920", "Q22494", "WBGene00020507", "Q23680", "WBGene00006918", "P34462", "WBGene00010130", "Q9XW92", "WBGene00013025", "Q19626", "WBGene00006921", "Q9N5A0", "WBGene00004959", "Q95X44", "WBGene00006917", "P91303", "WBGene00006919", "G5EGP4", "WBGene00006915", "P30628", "WBGene00006768", "B2MZD0", "WBGene00006916", "G5EEK9", "WBGene00006914", "C0HLB3", "WBGene00006911", "C0HLB4", "WBGene00006912", "G5EDB8", "WBGene00006913", "Q95YD5", "WBGene00016258", "Q20591", "WBGene00009882", "Q9XXU9", "WBGene00006920", "Q22494", "WBGene00020507", "Q23680", "WBGene00006918", "P34462", "WBGene00010130", "Q9XW92", "WBGene00013025", "Q19626", "WBGene00006921", "Q9N5A0", "WBGene00004959", "Q95X44", "WBGene00006917", "P91303", "WBGene00006919", "Q9TYW1", "WBGene00021952" ] }, "reaction_10555984": { "compartment": "compartment_70101", "id": "reaction_10555984", "reactome": "R-CEL-5687107", "name": "MAPK4,6 translocate to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10555976" ], "products": [ "species_10555982" ], "modifiers": [], "additional_components": [ "P39745", "WBGene00003401", "P39745", "WBGene00003401" ] }, "reaction_10555986": { "compartment": "compartment_7660", "id": "reaction_10555986", "reactome": "R-CEL-5687109", "name": "MAPK4,6 translocate to the cytoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10555982" ], "products": [ "species_10555976" ], "modifiers": [ [ "species_10511186", "catalyst" ] ], "additional_components": [ "P39745", "WBGene00003401", "P39745", "WBGene00003401", "WBGene00002078" ] }, "reaction_10520692": { "compartment": "compartment_70101", "id": "reaction_10520692", "reactome": "R-CEL-389788", "name": "Activation of PAKs by RAC1 and CDC42", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10520686", "species_10520664" ], "products": [ "species_10520690", "species_10520688" ], "modifiers": [], "additional_components": [ "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "species_29438", "Q03206", "ced-10", "Q05062", "WBGene00000390", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "species_29438", "Q03206", "ced-10", "Q05062", "WBGene00000390", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911" ] }, "reaction_10555989": { "compartment": "compartment_70101", "id": "reaction_10555989", "reactome": "R-CEL-5687112", "name": "MAPK6 is degraded by the 26S proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10555953" ], "products": [ "species_10502375" ], "modifiers": [ [ "species_10502572", "catalyst" ] ], "additional_components": [ "WBGene00003401", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "P91477", "WBGene00003950", "Q95PZ7", "WBGene00013435", "Q18115", "WBGene00004459", "O62102", "WBGene00003948", "O17071", "WBGene00004504", "Q10920", "WBGene00016623", "P34286", "WBGene00003952", "Q9XTT9", "WBGene00004506", "Q23449", "WBGene00004468", "Q95005", "WBGene00003925", "P46502", "WBGene00004503", "O61792", "WBGene00004464", "O17586", "WBGene00003922", "O76371", "WBGene00004505", "Q20585", "WBGene00004463", "Q95008", "WBGene00003926", "Q18787", "WBGene00004501", "Q20058", "WBGene00009445", "Q9N599", "WBGene00003924", "O16368", "WBGene00004502", "O61742", "WBGene00004466", "Q09583", "WBGene00003928", "Q966I8", "WBGene00003947", "Q04908", "WBGene00004460", "Q9XUV0", "WBGene00003951", "Q27488", "WBGene00003923", "Q9GZH5", "WBGene00004458", "O44156", "WBGene00003927", "Q22253", "WBGene00004465", "O76577", "WBGene00004467", "P90868", "WBGene00003953", "Q19324", "WBGene00004461", "Q17971", "WBGene00007588", "Q23237", "WBGene00003949", "Q20938", "WBGene00004462" ] }, "reaction_10556932": { "compartment": "compartment_7660", "id": "reaction_10556932", "reactome": "R-CEL-5692749", "name": "CDC14A,B bind MAPK6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10556926", "species_10556924" ], "products": [ "species_10556930" ], "modifiers": [], "additional_components": [ "WBGene00000383", "WBGene00003401", "P39745", "WBGene00003401", "P81299", "WBGene00000383" ] }, "reaction_10556937": { "compartment": "compartment_7660", "id": "reaction_10556937", "reactome": "R-CEL-5692754", "name": "CDC14A,B dephosphorylate p-3S,T MAPK6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10556930" ], "products": [ "species_113550", "species_10556934" ], "modifiers": [ [ "species_10556930", "catalyst" ] ], "additional_components": [ "P39745", "WBGene00003401", "P81299", "WBGene00000383", "P39745", "WBGene00003401", "P81299", "WBGene00000383", "P39745", "WBGene00003401", "P81299", "WBGene00000383" ] }, "reaction_10555993": { "compartment": "compartment_70101", "id": "reaction_10555993", "reactome": "R-CEL-5687126", "name": "p-S215 FOXO3 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10555974" ], "products": [ "species_10555970" ], "modifiers": [], "additional_components": [ "WBGene00000912", "WBGene00000912" ] }, "reaction_10555963": { "compartment": "compartment_70101", "id": "reaction_10555963", "reactome": "R-CEL-5687086", "name": "PAK1,2,3 phosphorylates MAPK6,4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10555955" ], "products": [ "species_29370", "species_10555958" ], "modifiers": [ [ "species_10521284", "catalyst" ] ], "additional_components": [ "WBGene00003401", "WBGene00003401", "Q17850", "WBGene00003911", "G5EGQ3", "WBGene00003144" ] }, "reaction_10556940": { "compartment": "compartment_7660", "id": "reaction_10556940", "reactome": "R-CEL-5692755", "name": "CDK1 phosphorylates MAPK6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10555980" ], "products": [ "species_113582", "species_10556924" ], "modifiers": [ [ "species_10511154", "catalyst" ] ], "additional_components": [ "WBGene00003401", "WBGene00003401", "WBGene00000405" ] }, "reaction_10555185": { "compartment": "compartment_876", "id": "reaction_10555185", "reactome": "R-CEL-5675194", "name": "Activated MAPK phosphorylates RAF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10554998" ], "products": [ "species_10555183", "species_29370" ], "modifiers": [ [ "species_10555165", "catalyst" ] ], "additional_components": [ "WBGene00003030", "WBGene00003030", "P39745", "WBGene00003401" ] }, "reaction_10555193": { "compartment": "compartment_876", "id": "reaction_10555193", "reactome": "R-CEL-5675198", "name": "Activated MAPKs phosphorylate BRAF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10555000" ], "products": [ "species_29370", "species_10555191" ], "modifiers": [ [ "species_10555165", "catalyst" ] ], "additional_components": [ "WBGene00003030", "WBGene00003030", "P39745", "WBGene00003401" ] }, "reaction_10555176": { "compartment": "compartment_70101", "id": "reaction_10555176", "reactome": "R-CEL-5674496", "name": "Activated MAPKs phosphorylate MAP2K1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10555059" ], "products": [ "species_29370", "species_10555173" ], "modifiers": [ [ "species_10555165", "catalyst" ] ], "additional_components": [ "Q10664", "WBGene00003186", "Q10664", "WBGene00003186", "P39745", "WBGene00003401" ] }, "reaction_10555140": { "compartment": "compartment_20699", "id": "reaction_10555140", "reactome": "R-CEL-5674140", "name": "PAQR3 binds inactive RAFs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10554946", "species_10555136" ], "products": [ "species_10555138" ], "modifiers": [], "additional_components": [ "WBGene00003030", "WBGene00013457", "Q9U1V1", "WBGene00013457", "Q07292", "WBGene00003030" ] }, "reaction_10555236": { "compartment": "compartment_876", "id": "reaction_10555236", "reactome": "R-CEL-5675431", "name": "PP2A dephosphorylates RAF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10555230", "species_29356" ], "products": [ "species_29372", "species_10555234" ], "modifiers": [ [ "species_10513555", "catalyst" ], [ "species_10555183", "catalyst" ] ], "additional_components": [ "Q07292", "WBGene00003030", "species_29438", "P22981", "WBGene00002335", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "Q07292", "WBGene00003030", "species_29438", "P22981", "WBGene00002335", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "WBGene00003030" ] }, "reaction_10555110": { "compartment": "compartment_876", "id": "reaction_10555110", "reactome": "R-CEL-5674022", "name": "BRAP autoubiquitinates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10555100", "species_10502375" ], "products": [ "species_10555107" ], "modifiers": [ [ "species_10555100", "catalyst" ] ], "additional_components": [ "species_29438", "P22981", "WBGene00002335", "Q95QN6", "WBGene00017144", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "Q95QN6", "WBGene00017144", "species_29438", "P22981", "WBGene00002335", "species_29438", "P22981", "WBGene00002335", "Q95QN6", "WBGene00017144" ] }, "reaction_10566377": { "compartment": "compartment_70101", "id": "reaction_10566377", "reactome": "R-CEL-8867654", "name": "PTPN3 binds p-T183,Y185 MAPK12", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10525306", "species_10566373" ], "products": [ "species_10566375" ], "modifiers": [], "additional_components": [ "Q17446", "WBGene00004055", "Q8MXI4", "WBGene00004056", "WBGene00004213", "P28191", "WBGene00004213", "Q17446", "WBGene00004055", "Q8MXI4", "WBGene00004056" ] }, "reaction_10566488": { "compartment": "compartment_70101", "id": "reaction_10566488", "reactome": "R-CEL-8868118", "name": "MAPK12 phosphorylates PTPN3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10566375" ], "products": [ "species_29370", "species_10566485" ], "modifiers": [ [ "species_10566375", "catalyst" ] ], "additional_components": [ "P28191", "WBGene00004213", "Q17446", "WBGene00004055", "Q8MXI4", "WBGene00004056", "P28191", "WBGene00004213", "Q17446", "WBGene00004055", "Q8MXI4", "WBGene00004056", "P28191", "WBGene00004213", "Q17446", "WBGene00004055", "Q8MXI4", "WBGene00004056" ] }, "reaction_10555226": { "compartment": "compartment_876", "id": "reaction_10555226", "reactome": "R-CEL-5675417", "name": "PEBP1 binds activated RAF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10555049", "species_10555044" ], "products": [ "species_10555051" ], "modifiers": [], "additional_components": [ "WBGene00018218", "Q07292", "WBGene00003030", "species_29438", "P22981", "WBGene00002335", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "Q07292", "WBGene00003030", "species_29438", "P22981", "WBGene00002335", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "O16264", "WBGene00018218" ] }, "reaction_10555245": { "compartment": "compartment_876", "id": "reaction_10555245", "reactome": "R-CEL-5675433", "name": "PP5 dephosphorylates RAF1 S338", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10555044" ], "products": [ "species_10555230", "species_29372" ], "modifiers": [ [ "species_10555242", "catalyst" ] ], "additional_components": [ "Q07292", "WBGene00003030", "species_29438", "P22981", "WBGene00002335", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "Q07292", "WBGene00003030", "species_29438", "P22981", "WBGene00002335", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "WBGene00012665" ] }, "reaction_10566380": { "compartment": "compartment_70101", "id": "reaction_10566380", "reactome": "R-CEL-8867658", "name": "PTPN3 dephosphorylates MAPK12", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10566375" ], "products": [ "species_29372", "species_10566373", "species_10526147" ], "modifiers": [ [ "species_10566375", "catalyst" ] ], "additional_components": [ "P28191", "WBGene00004213", "Q17446", "WBGene00004055", "Q8MXI4", "WBGene00004056", "WBGene00004213", "Q8MXI4", "WBGene00004056", "Q17446", "WBGene00004055", "P28191", "WBGene00004213", "Q17446", "WBGene00004055", "Q8MXI4", "WBGene00004056" ] }, "reaction_10555102": { "compartment": "compartment_876", "id": "reaction_10555102", "reactome": "R-CEL-5674018", "name": "BRAP binds RAS:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10555098", "species_10511481" ], "products": [ "species_10555100" ], "modifiers": [], "additional_components": [ "WBGene00017144", "species_29438", "P22981", "WBGene00002335", "species_29438", "P22981", "WBGene00002335", "Q95QN6", "WBGene00017144" ] }, "reaction_10572703": { "compartment": "compartment_876", "id": "reaction_10572703", "reactome": "R-CEL-9649736", "name": "RAS intrinsic GTPase activity hydrolyzes GTP to GDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10511481" ], "products": [ "species_10512175" ], "modifiers": [ [ "species_10511481", "catalyst" ] ], "additional_components": [ "species_29438", "P22981", "WBGene00002335", "species_29420", "P22981", "WBGene00002335", "species_29438", "P22981", "WBGene00002335" ] }, "reaction_10572700": { "compartment": "compartment_876", "id": "reaction_10572700", "reactome": "R-CEL-9649735", "name": "Intrinsic nucleotide exchange on RAS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10512175", "species_29438" ], "products": [ "species_29420", "species_10511481" ], "modifiers": [], "additional_components": [ "species_29420", "P22981", "WBGene00002335", "species_29438", "P22981", "WBGene00002335" ] }, "reaction_10572741": { "compartment": "compartment_876", "id": "reaction_10572741", "reactome": "R-CEL-9653108", "name": "Raf dimer inhibitors bind RAF heterodimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9657579", "species_10554994" ], "products": [ "species_10555084" ], "modifiers": [], "additional_components": [ "Q07292", "WBGene00003030", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "species_29438", "P22981", "WBGene00002335", "Q07292", "WBGene00003030", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "species_29438", "P22981", "WBGene00002335" ] }, "reaction_10554964": { "compartment": "compartment_70101", "id": "reaction_10554964", "reactome": "R-CEL-5672960", "name": "YWHAB dimer dissociates from dephosphorylated RAF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10554962" ], "products": [ "species_10507067", "species_10554906" ], "modifiers": [], "additional_components": [ "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "Q07292", "WBGene00003030", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "WBGene00003030" ] }, "reaction_10554996": { "compartment": "compartment_876", "id": "reaction_10554996", "reactome": "R-CEL-5672966", "name": "RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10554906", "species_10554935" ], "products": [ "species_10554994" ], "modifiers": [], "additional_components": [ "WBGene00003030", "Q07292", "WBGene00003030", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "species_29438", "P22981", "WBGene00002335", "Q07292", "WBGene00003030", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "species_29438", "P22981", "WBGene00002335" ] }, "reaction_10554967": { "compartment": "compartment_70101", "id": "reaction_10554967", "reactome": "R-CEL-5672961", "name": "PP2A dephosphorylates inactive RAFs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10554954" ], "products": [ "species_29372", "species_10554962" ], "modifiers": [ [ "species_10513555", "catalyst" ] ], "additional_components": [ "Q07292", "WBGene00003030", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "Q07292", "WBGene00003030" ] }, "reaction_10572954": { "compartment": "compartment_876", "id": "reaction_10572954", "reactome": "R-CEL-9658445", "name": "MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10554954" ], "products": [ "species_29372", "species_10554962" ], "modifiers": [ [ "species_10572951", "catalyst" ] ], "additional_components": [ "Q07292", "WBGene00003030", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "Q07292", "WBGene00003030", "Q27497", "WBGene00001747", "P48727", "WBGene00001748", "Q22875", "WBGene00004929", "G5EGA7", "WBGene00004311", "species_29438" ] }, "reaction_10554956": { "compartment": "compartment_70101", "id": "reaction_10554956", "reactome": "R-CEL-5672951", "name": "Inactive RAFs bind YWHAB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10507067", "species_10554946" ], "products": [ "species_10554954" ], "modifiers": [], "additional_components": [ "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "WBGene00003030", "Q07292", "WBGene00003030", "P41932", "WBGene00003920", "Q20655", "WBGene00001502" ] }, "reaction_10554942": { "compartment": "compartment_876", "id": "reaction_10554942", "reactome": "R-CEL-5672950", "name": "\"Activator\" RAF:YWHAB dimer binds RAS:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10511481", "species_10554933" ], "products": [ "species_10554935" ], "modifiers": [ [ "species_10554940", "catalyst" ] ], "additional_components": [ "species_29438", "P22981", "WBGene00002335", "Q07292", "WBGene00003030", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "Q07292", "WBGene00003030", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "species_29438", "P22981", "WBGene00002335", "WBGene00004014" ] }, "reaction_10572966": { "compartment": "compartment_876", "id": "reaction_10572966", "reactome": "R-CEL-9660557", "name": "RAS:GTP binds RAL GDS proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10511486", "species_10572962" ], "products": [ "species_10572964" ], "modifiers": [], "additional_components": [ "WBGene00017891", "P22981", "WBGene00002335", "species_29438", "P22981", "WBGene00002335", "species_29438", "Q19852", "WBGene00017891" ] }, "reaction_10572576": { "compartment": "compartment_12045", "id": "reaction_10572576", "reactome": "R-CEL-9647977", "name": "ICMT methylates S-Farn RAS proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10572567", "species_71284" ], "products": [ "species_10572572", "species_71285" ], "modifiers": [ [ "species_10558332", "catalyst" ], [ "species_10572574", "inhibitor" ] ], "additional_components": [ "WBGene00002335", "WBGene00002335", "species_216785", "P91402", "WBGene00019710", "species_216785", "P91402", "WBGene00019710" ] }, "reaction_10572896": { "compartment": "compartment_876", "id": "reaction_10572896", "reactome": "R-CEL-9654521", "name": "Calmodulin dissociates KRAS4B from the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10549080" ], "products": [ "species_10572894" ], "modifiers": [], "additional_components": [ "species_74016", "Q11083", "WBGene00020378", "P04630", "WBGene00000285", "G5EF37", "WBGene00003934", "A0A2C9C3L3", "WBGene00020378", "Q18136", "WBGene00006861", "Q09665", "WBGene00006583", "O02159", "WBGene00020378", "G5EDZ8", "WBGene00000288", "Q94288", "WBGene00000287", "Q09980", "WBGene00017394", "O16305", "WBGene00000552", "G5EEG0", "WBGene00000286", "P22981", "WBGene00002335", "species_74016", "Q11083", "WBGene00020378", "P04630", "WBGene00000285", "G5EF37", "WBGene00003934", "A0A2C9C3L3", "WBGene00020378", "Q18136", "WBGene00006861", "Q09665", "WBGene00006583", "O02159", "WBGene00020378", "G5EDZ8", "WBGene00000288", "Q94288", "WBGene00000287", "Q09980", "WBGene00017394", "O16305", "WBGene00000552", "G5EEG0", "WBGene00000286", "P22981", "WBGene00002335" ] }, "reaction_10572610": { "compartment": "compartment_20699", "id": "reaction_10572610", "reactome": "R-CEL-9647982", "name": "S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10572572", "species_200993" ], "products": [ "species_76194", "species_10572592" ], "modifiers": [ [ "species_10572607", "catalyst" ] ], "additional_components": [ "WBGene00002335", "WBGene00002335", "Q9U204", "WBGene00013323", "Q9XWD7", "WBGene00012948" ] }, "reaction_10572612": { "compartment": "compartment_70101", "id": "reaction_10572612", "reactome": "R-CEL-9647987", "name": "FNTB inhibitors bind FNTA:FNTB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9653479", "species_10544771" ], "products": [ "species_10572587" ], "modifiers": [], "additional_components": [ "Q19752", "WBGene00006465", "O44501", "WBGene00019823", "Q19752", "WBGene00006465", "O44501", "WBGene00019823" ] }, "reaction_10572679": { "compartment": "compartment_12045", "id": "reaction_10572679", "reactome": "R-CEL-9647999", "name": "RCE1 cleaves S-Farn proRAS proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10572583" ], "products": [ "species_10572567" ], "modifiers": [ [ "species_10572676", "catalyst" ] ], "additional_components": [ "WBGene00002335", "WBGene00002335", "WBGene00001406" ] }, "reaction_10572902": { "compartment": "compartment_70101", "id": "reaction_10572902", "reactome": "R-CEL-9654523", "name": "ARL2:GTP bind PDE6D on KRAS4B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10572898", "species_10550993" ], "products": [ "species_10572900" ], "modifiers": [], "additional_components": [ "Q18268", "WBGene00003966", "species_74016", "Q11083", "WBGene00020378", "P04630", "WBGene00000285", "G5EF37", "WBGene00003934", "A0A2C9C3L3", "WBGene00020378", "Q18136", "WBGene00006861", "Q09665", "WBGene00006583", "O02159", "WBGene00020378", "G5EDZ8", "WBGene00000288", "Q94288", "WBGene00000287", "Q09980", "WBGene00017394", "O16305", "WBGene00000552", "G5EEG0", "WBGene00000286", "P22981", "WBGene00002335", "species_29438", "Q19705", "WBGene00001358", "species_29438", "Q19705", "WBGene00001358", "Q18268", "WBGene00003966", "species_74016", "Q11083", "WBGene00020378", "P04630", "WBGene00000285", "G5EF37", "WBGene00003934", "A0A2C9C3L3", "WBGene00020378", "Q18136", "WBGene00006861", "Q09665", "WBGene00006583", "O02159", "WBGene00020378", "G5EDZ8", "WBGene00000288", "Q94288", "WBGene00000287", "Q09980", "WBGene00017394", "O16305", "WBGene00000552", "G5EEG0", "WBGene00000286", "P22981", "WBGene00002335" ] }, "reaction_10572906": { "compartment": "compartment_70101", "id": "reaction_10572906", "reactome": "R-CEL-9654525", "name": "PDE6D binds S-Farn-Me KRAS4B:CALM:4 Ca2+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10572894", "species_10553585" ], "products": [ "species_10572898" ], "modifiers": [ [ "species_10572904", "inhibitor" ] ], "additional_components": [ "species_74016", "Q11083", "WBGene00020378", "P04630", "WBGene00000285", "G5EF37", "WBGene00003934", "A0A2C9C3L3", "WBGene00020378", "Q18136", "WBGene00006861", "Q09665", "WBGene00006583", "O02159", "WBGene00020378", "G5EDZ8", "WBGene00000288", "Q94288", "WBGene00000287", "Q09980", "WBGene00017394", "O16305", "WBGene00000552", "G5EEG0", "WBGene00000286", "P22981", "WBGene00002335", "WBGene00003966", "Q18268", "WBGene00003966", "species_74016", "Q11083", "WBGene00020378", "P04630", "WBGene00000285", "G5EF37", "WBGene00003934", "A0A2C9C3L3", "WBGene00020378", "Q18136", "WBGene00006861", "Q09665", "WBGene00006583", "O02159", "WBGene00020378", "G5EDZ8", "WBGene00000288", "Q94288", "WBGene00000287", "Q09980", "WBGene00017394", "O16305", "WBGene00000552", "G5EEG0", "WBGene00000286", "P22981", "WBGene00002335", "Q18268", "WBGene00003966" ] }, "reaction_10572589": { "compartment": "compartment_70101", "id": "reaction_10572589", "reactome": "R-CEL-9647978", "name": "pro-RAS proteins are farnesylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10572579", "species_2530486" ], "products": [ "species_111294", "species_10572583" ], "modifiers": [ [ "species_10544771", "catalyst" ], [ "species_10572587", "inhibitor" ] ], "additional_components": [ "WBGene00002335", "WBGene00002335", "Q19752", "WBGene00006465", "O44501", "WBGene00019823", "Q19752", "WBGene00006465", "O44501", "WBGene00019823" ] }, "reaction_10572909": { "compartment": "compartment_876", "id": "reaction_10572909", "reactome": "R-CEL-9654533", "name": "KRAS4B recycles to the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10572900" ], "products": [ "species_10511479", "species_10508995", "species_10550993", "species_10553585" ], "modifiers": [], "additional_components": [ "species_29438", "Q19705", "WBGene00001358", "Q18268", "WBGene00003966", "species_74016", "Q11083", "WBGene00020378", "P04630", "WBGene00000285", "G5EF37", "WBGene00003934", "A0A2C9C3L3", "WBGene00020378", "Q18136", "WBGene00006861", "Q09665", "WBGene00006583", "O02159", "WBGene00020378", "G5EDZ8", "WBGene00000288", "Q94288", "WBGene00000287", "Q09980", "WBGene00017394", "O16305", "WBGene00000552", "G5EEG0", "WBGene00000286", "P22981", "WBGene00002335", "WBGene00002335", "species_74016", "Q11083", "WBGene00020378", "P04630", "WBGene00000285", "G5EF37", "WBGene00003934", "A0A2C9C3L3", "WBGene00020378", "Q18136", "WBGene00006861", "Q09665", "WBGene00006583", "O02159", "WBGene00020378", "G5EDZ8", "WBGene00000288", "Q94288", "WBGene00000287", "Q09980", "WBGene00017394", "O16305", "WBGene00000552", "G5EEG0", "WBGene00000286", "species_29438", "Q19705", "WBGene00001358", "WBGene00003966" ] }, "reaction_10572753": { "compartment": "compartment_70101", "id": "reaction_10572753", "reactome": "R-CEL-9653503", "name": "KRAS4B is phosphorylated on serine 181", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10511479" ], "products": [ "species_29370", "species_10572744" ], "modifiers": [ [ "species_10572750", "catalyst" ] ], "additional_components": [ "WBGene00002335", "WBGene00002335", "species_112275", "P34722", "WBGene00006599", "H2KYN2", "WBGene00015650", "O76360", "WBGene00001173", "species_30991" ] }, "reaction_10572881": { "compartment": "compartment_876", "id": "reaction_10572881", "reactome": "R-CEL-9653585", "name": "S-Farn-Me KRAS4B binds calmodulin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10511479", "species_10508995" ], "products": [ "species_10549080" ], "modifiers": [ [ "species_10572744", "inhibitor" ] ], "additional_components": [ "WBGene00002335", "species_74016", "Q11083", "WBGene00020378", "P04630", "WBGene00000285", "G5EF37", "WBGene00003934", "A0A2C9C3L3", "WBGene00020378", "Q18136", "WBGene00006861", "Q09665", "WBGene00006583", "O02159", "WBGene00020378", "G5EDZ8", "WBGene00000288", "Q94288", "WBGene00000287", "Q09980", "WBGene00017394", "O16305", "WBGene00000552", "G5EEG0", "WBGene00000286", "species_74016", "Q11083", "WBGene00020378", "P04630", "WBGene00000285", "G5EF37", "WBGene00003934", "A0A2C9C3L3", "WBGene00020378", "Q18136", "WBGene00006861", "Q09665", "WBGene00006583", "O02159", "WBGene00020378", "G5EDZ8", "WBGene00000288", "Q94288", "WBGene00000287", "Q09980", "WBGene00017394", "O16305", "WBGene00000552", "G5EEG0", "WBGene00000286", "P22981", "WBGene00002335", "WBGene00002335" ] }, "reaction_10572598": { "compartment": "compartment_876", "id": "reaction_10572598", "reactome": "R-CEL-9647980", "name": "mature RAS proteins translocate to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10572592" ], "products": [ "species_10511477" ], "modifiers": [], "additional_components": [ "WBGene00002335", "WBGene00002335" ] }, "reaction_10572886": { "compartment": "compartment_17906", "id": "reaction_10572886", "reactome": "R-CEL-9653592", "name": "pS181-S-Farn-Me KRAS4B translocates to the outer mitochondrial membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10572744" ], "products": [ "species_10572884" ], "modifiers": [], "additional_components": [ "WBGene00002335", "WBGene00002335" ] }, "reaction_10572696": { "compartment": "compartment_12045", "id": "reaction_10572696", "reactome": "R-CEL-9649732", "name": "Mature S-Farn-Me KRAS4B translocates to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10572572" ], "products": [ "species_10511479" ], "modifiers": [], "additional_components": [ "WBGene00002335", "WBGene00002335" ] }, "reaction_10572666": { "compartment": "compartment_876", "id": "reaction_10572666", "reactome": "R-CEL-9647991", "name": "Palmostatin B binds RAS depalmitoylases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9647934", "species_10572662" ], "products": [ "species_10572664" ], "modifiers": [], "additional_components": [ "Q9XVA7", "WBGene00044003", "Q21221", "WBGene00045192", "Q5FC17", "WBGene00044003", "Q7JKU8", "WBGene00044003", "Q9BL52", "WBGene00044003", "A0A061ACY0", "WBGene00010564", "Q9XVA7", "WBGene00044003", "Q21221", "WBGene00045192", "Q5FC17", "WBGene00044003", "Q7JKU8", "WBGene00044003", "Q9BL52", "WBGene00044003", "A0A061ACY0", "WBGene00010564" ] }, "reaction_10572698": { "compartment": "compartment_876", "id": "reaction_10572698", "reactome": "R-CEL-9649733", "name": "mature p21 RAS binds GDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10511471", "species_29420" ], "products": [ "species_10512175" ], "modifiers": [], "additional_components": [ "WBGene00002335", "species_29420", "P22981", "WBGene00002335" ] }, "reaction_10572890": { "compartment": "compartment_17906", "id": "reaction_10572890", "reactome": "R-CEL-9653595", "name": "pS181-S-Farn-Me KRAS4B binds BCL2L1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10572884", "species_10528114" ], "products": [ "species_10572888" ], "modifiers": [], "additional_components": [ "WBGene00002335", "WBGene00000423", "P41958", "WBGene00000423", "P22981", "WBGene00002335" ] }, "reaction_10572669": { "compartment": "compartment_876", "id": "reaction_10572669", "reactome": "R-CEL-9647994", "name": "RAS proteins are depalmitoylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10511477" ], "products": [ "species_10511479", "species_8848337" ], "modifiers": [ [ "species_10572662", "catalyst" ], [ "species_10572664", "inhibitor" ] ], "additional_components": [ "WBGene00002335", "WBGene00002335", "Q9XVA7", "WBGene00044003", "Q21221", "WBGene00045192", "Q5FC17", "WBGene00044003", "Q7JKU8", "WBGene00044003", "Q9BL52", "WBGene00044003", "A0A061ACY0", "WBGene00010564", "Q9XVA7", "WBGene00044003", "Q21221", "WBGene00045192", "Q5FC17", "WBGene00044003", "Q7JKU8", "WBGene00044003", "Q9BL52", "WBGene00044003", "A0A061ACY0", "WBGene00010564" ] }, "reaction_10554992": { "compartment": "compartment_876", "id": "reaction_10554992", "reactome": "R-CEL-5672965", "name": "RAS GEFs promote RAS nucleotide exchange", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10512175", "species_29438" ], "products": [ "species_29420", "species_10511481" ], "modifiers": [ [ "species_10554989", "catalyst" ] ], "additional_components": [ "species_29420", "P22981", "WBGene00002335", "species_29438", "P22981", "WBGene00002335", "P29355", "WBGene00004774", "Q9N5D3", "WBGene00004947", "P24348", "WBGene00002299", "species_114519", "Q19770", "WBGene00009100", "W6RS10", "WBGene00019902", "Q9N413", "WBGene00004249", "G5EGT9", "WBGene00003007", "A0A1I6CMA1", "WBGene00020678", "Q9XWK4", "WBGene00013202", "Q9XVQ7", "WBGene00008711", "E0AHA7", "WBGene00006803", "G5EFW3", "WBGene00004855", "Q21408", "WBGene00004951", "Q7YZG5", "WBGene00021702", "C6KRM7", "WBGene00004372", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q95YD4", "WBGene00002213", "G5EDB9", "WBGene00004254" ] }, "reaction_10572929": { "compartment": "compartment_876", "id": "reaction_10572929", "reactome": "R-CEL-9658253", "name": "RAS:GTP binds PI3K", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10506892", "species_10511481" ], "products": [ "species_10572927" ], "modifiers": [], "additional_components": [ "G5EDP9", "WBGene00000001", "Q94125", "WBGene00000090", "species_29438", "P22981", "WBGene00002335", "species_29438", "P22981", "WBGene00002335", "G5EDP9", "WBGene00000001", "Q94125", "WBGene00000090" ] }, "reaction_10542176": { "compartment": "compartment_70101", "id": "reaction_10542176", "reactome": "R-CEL-2032768", "name": "Translocation of WWTR1 (TAZ) to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10541983" ], "products": [ "species_10542174" ], "modifiers": [], "additional_components": [ "WBGene00008748", "WBGene00008748" ] }, "reaction_10542432": { "compartment": "compartment_70101", "id": "reaction_10542432", "reactome": "R-CEL-2066299", "name": "DVL2 binds phosphorylated WWTR1 (TAZ)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10515048", "species_10541986" ], "products": [ "species_10542430" ], "modifiers": [], "additional_components": [ "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "WBGene00008748", "Q19404", "WBGene00008748", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241" ] }, "reaction_10542178": { "compartment": "compartment_70101", "id": "reaction_10542178", "reactome": "R-CEL-2032770", "name": "Translocation of YAP1 to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10532629" ], "products": [ "species_10532633" ], "modifiers": [], "additional_components": [ "WBGene00008748", "WBGene00008748" ] }, "reaction_10542339": { "compartment": "compartment_70101", "id": "reaction_10542339", "reactome": "R-CEL-2064406", "name": "Translocation of YAP1:ZO-2 (TJP2) to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10542333" ], "products": [ "species_10542337" ], "modifiers": [], "additional_components": [ "Q19404", "WBGene00008748", "Q8I103", "WBGene00013683", "Q19404", "WBGene00008748", "Q8I103", "WBGene00013683" ] }, "reaction_10541988": { "compartment": "compartment_70101", "id": "reaction_10541988", "reactome": "R-CEL-2028661", "name": "Phosphorylation of WWTR1 (TAZ) by LATS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10541983", "species_113592" ], "products": [ "species_29370", "species_10541986" ], "modifiers": [ [ "species_10541961", "catalyst" ] ], "additional_components": [ "WBGene00008748", "WBGene00008748", "O45797", "WBGene00007047", "Q20186", "WBGene00009551" ] }, "reaction_10542345": { "compartment": "compartment_70101", "id": "reaction_10542345", "reactome": "R-CEL-2064417", "name": "WWTR1 (TAZ) binds ZO-1 (TJP1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10541983", "species_10542341" ], "products": [ "species_10542343" ], "modifiers": [], "additional_components": [ "WBGene00008748", "WBGene00013683", "Q8I103", "WBGene00013683", "Q19404", "WBGene00008748" ] }, "reaction_10541964": { "compartment": "compartment_70101", "id": "reaction_10541964", "reactome": "R-CEL-2028583", "name": "Phosphorylation of YAP by LATS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10532629" ], "products": [ "species_29370", "species_10541959" ], "modifiers": [ [ "species_10541961", "catalyst" ] ], "additional_components": [ "WBGene00008748", "WBGene00008748", "O45797", "WBGene00007047", "Q20186", "WBGene00009551" ] }, "reaction_10542349": { "compartment": "compartment_70101", "id": "reaction_10542349", "reactome": "R-CEL-2064418", "name": "WWTR1 (TAZ) binds ZO-2 (TJP2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10541983", "species_10542331" ], "products": [ "species_10542347" ], "modifiers": [], "additional_components": [ "WBGene00008748", "WBGene00013683", "Q8I103", "WBGene00013683", "Q19404", "WBGene00008748" ] }, "reaction_10542351": { "compartment": "compartment_70101", "id": "reaction_10542351", "reactome": "R-CEL-2064421", "name": "YAP1 binds ZO-2 (TJP2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10542331", "species_10532629" ], "products": [ "species_10542333" ], "modifiers": [], "additional_components": [ "WBGene00013683", "WBGene00008748", "Q19404", "WBGene00008748", "Q8I103", "WBGene00013683" ] }, "reaction_10541973": { "compartment": "compartment_70101", "id": "reaction_10541973", "reactome": "R-CEL-2028598", "name": "Phosphorylation of YAP by LATS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10532629" ], "products": [ "species_29370", "species_10541970" ], "modifiers": [ [ "species_10541956", "catalyst" ] ], "additional_components": [ "WBGene00008748", "WBGene00008748", "Q20186", "WBGene00009551", "O45797", "WBGene00007047" ] }, "reaction_10542327": { "compartment": "compartment_70101", "id": "reaction_10542327", "reactome": "R-CEL-2059926", "name": "NPHP4 protein binds LATS proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10541935", "species_10542323" ], "products": [ "species_10542325" ], "modifiers": [], "additional_components": [ "WBGene00007047", "WBGene00011261", "G5ECP0", "WBGene00011261", "O45797", "WBGene00007047" ] }, "reaction_10541975": { "compartment": "compartment_70101", "id": "reaction_10541975", "reactome": "R-CEL-2028626", "name": "Phosphorylated MOB1A proteins associate with LATS proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10541935", "species_10541944" ], "products": [ "species_10541946" ], "modifiers": [], "additional_components": [ "WBGene00007047", "WBGene00009551", "Q20186", "WBGene00009551", "O45797", "WBGene00007047" ] }, "reaction_10542329": { "compartment": "compartment_70101", "id": "reaction_10542329", "reactome": "R-CEL-2060328", "name": "Phosphorylation of WWTR1 (TAZ) by LATS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10541983", "species_113592" ], "products": [ "species_29370", "species_10541986" ], "modifiers": [ [ "species_10541956", "catalyst" ] ], "additional_components": [ "WBGene00008748", "WBGene00008748", "Q20186", "WBGene00009551", "O45797", "WBGene00007047" ] }, "reaction_10541981": { "compartment": "compartment_70101", "id": "reaction_10541981", "reactome": "R-CEL-2028644", "name": "YWHAB (14-3-3 beta/alpha) dimer binds phosphorylated YAP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10507067", "species_10541959" ], "products": [ "species_10541979" ], "modifiers": [], "additional_components": [ "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "WBGene00008748", "Q19404", "WBGene00008748", "P41932", "WBGene00003920", "Q20655", "WBGene00001502" ] }, "reaction_10573312": { "compartment": "compartment_263163", "id": "reaction_10573312", "reactome": "R-CEL-9706390", "name": "RHOBTB3 binds interacting proteins at trans-Golgi network", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10573308", "species_10573304" ], "products": [ "species_10573310" ], "modifiers": [], "additional_components": [ "O01501", "WBGene00000871", "Q19213", "WBGene00006922", "Q17796", "WBGene00004101", "Q22895", "WBGene00004780", "Q17391", "WBGene00000838", "Q03206", "ced-10", "Q94124", "WBGene00004287", "Q9BL44", "WBGene00022177", "species_29358", "Q03206", "ced-10", "Q94124", "WBGene00004287", "Q9BL44", "WBGene00022177", "species_29358", "O01501", "WBGene00000871", "Q19213", "WBGene00006922", "Q17796", "WBGene00004101", "Q22895", "WBGene00004780", "Q17391", "WBGene00000838" ] }, "reaction_10573314": { "compartment": "compartment_263163", "id": "reaction_10573314", "reactome": "R-CEL-9706393", "name": "RHOBTB3 binds ATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10573302" ], "products": [ "species_10573304" ], "modifiers": [], "additional_components": [ "Q03206", "ced-10", "Q94124", "WBGene00004287", "Q9BL44", "WBGene00022177", "Q03206", "ced-10", "Q94124", "WBGene00004287", "Q9BL44", "WBGene00022177", "species_29358" ] }, "reaction_10573319": { "compartment": "compartment_263163", "id": "reaction_10573319", "reactome": "R-CEL-9706399", "name": "RHOBTB3 hydrolyzes ATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10573304" ], "products": [ "species_29372", "species_10573316" ], "modifiers": [ [ "species_10573304", "catalyst" ] ], "additional_components": [ "Q03206", "ced-10", "Q94124", "WBGene00004287", "Q9BL44", "WBGene00022177", "species_29358", "Q03206", "ced-10", "Q94124", "WBGene00004287", "Q9BL44", "WBGene00022177", "species_113582", "Q03206", "ced-10", "Q94124", "WBGene00004287", "Q9BL44", "WBGene00022177", "species_29358" ] }, "reaction_10571460": { "compartment": "compartment_17906", "id": "reaction_10571460", "reactome": "R-CEL-9018815", "name": "RHOT1 binds effectors at the mitochondrial outer membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10571454", "species_10571444" ], "products": [ "species_10571458" ], "modifiers": [], "additional_components": [ "WBGene00020838", "Q94263", "WBGene00019544", "species_29438", "Q94263", "WBGene00019544", "species_29438", "P91503", "WBGene00020838" ] }, "reaction_10571449": { "compartment": "compartment_70101", "id": "reaction_10571449", "reactome": "R-CEL-9018814", "name": "RHOT1 hydrolyzes GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10571444" ], "products": [ "species_29372", "species_10571446" ], "modifiers": [ [ "species_10571444", "catalyst" ] ], "additional_components": [ "Q94263", "WBGene00019544", "species_29438", "Q94263", "WBGene00019544", "species_29420", "Q94263", "WBGene00019544", "species_29438" ] }, "reaction_10571466": { "compartment": "compartment_70101", "id": "reaction_10571466", "reactome": "R-CEL-9018824", "name": "RHOT2 binds effectors at the mitochondrial outer membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10571462", "species_10571444" ], "products": [ "species_10571464" ], "modifiers": [], "additional_components": [ "Q23424", "WBGene00001509", "P91503", "WBGene00020838", "Q94263", "WBGene00019544", "species_29438", "Q94263", "WBGene00019544", "species_29438", "Q23424", "WBGene00001509", "P91503", "WBGene00020838" ] }, "reaction_10571468": { "compartment": "compartment_70101", "id": "reaction_10571468", "reactome": "R-CEL-9018826", "name": "RHOT2 hydrolyzes GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10571444" ], "products": [ "species_29372", "species_10571446" ], "modifiers": [ [ "species_10571444", "catalyst" ] ], "additional_components": [ "Q94263", "WBGene00019544", "species_29438", "Q94263", "WBGene00019544", "species_29420", "Q94263", "WBGene00019544", "species_29438" ] }, "reaction_10564802": { "compartment": "compartment_70101", "id": "reaction_10564802", "reactome": "R-CEL-8849055", "name": "PTK6 binds ARHGAP35", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10564606", "species_10521590" ], "products": [ "species_10564800" ], "modifiers": [], "additional_components": [ "A0A0K3ARA3", "WBGene00020106", "Q10925", "WBGene00002207", "WBGene00010374", "O45611", "WBGene00010374", "A0A0K3ARA3", "WBGene00020106", "Q10925", "WBGene00002207" ] }, "reaction_10564808": { "compartment": "compartment_70101", "id": "reaction_10564808", "reactome": "R-CEL-8849068", "name": "PTK6 phosphorylates ARHGAP35", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10564800" ], "products": [ "species_10564606", "species_29370", "species_10564805" ], "modifiers": [ [ "species_10564800", "catalyst" ] ], "additional_components": [ "O45611", "WBGene00010374", "A0A0K3ARA3", "WBGene00020106", "Q10925", "WBGene00002207", "A0A0K3ARA3", "WBGene00020106", "Q10925", "WBGene00002207", "WBGene00010374", "O45611", "WBGene00010374", "A0A0K3ARA3", "WBGene00020106", "Q10925", "WBGene00002207" ] }, "reaction_10564731": { "compartment": "compartment_876", "id": "reaction_10564731", "reactome": "R-CEL-8848618", "name": "Activation of RAC1 by the PXN:CRK complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10541992" ], "products": [ "species_29420", "species_10509457" ], "modifiers": [ [ "species_10564728", "catalyst" ] ], "additional_components": [ "species_29420", "Q03206", "ced-10", "species_29438", "Q03206", "ced-10", "Q8STE5", "WBGene00000426", "Q95XA9", "WBGene00021238", "Q9NHC3", "WBGene00000416", "G5EEN3", "WBGene00000419" ] }, "reaction_10564813": { "compartment": "compartment_70101", "id": "reaction_10564813", "reactome": "R-CEL-8849082", "name": "ARHGAP35 stimulates RHOA GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10564810" ], "products": [ "species_10509486", "species_29372", "species_10564805" ], "modifiers": [ [ "species_10564810", "catalyst" ] ], "additional_components": [ "Q22038", "WBGene00004357", "species_29438", "O45611", "WBGene00010374", "Q22038", "WBGene00004357", "species_29420", "WBGene00010374", "Q22038", "WBGene00004357", "species_29438", "O45611", "WBGene00010374" ] }, "reaction_10564815": { "compartment": "compartment_70101", "id": "reaction_10564815", "reactome": "R-CEL-8849085", "name": "ARHGAP35 binds RHOA:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10564805", "species_10509488" ], "products": [ "species_10564810" ], "modifiers": [], "additional_components": [ "WBGene00010374", "Q22038", "WBGene00004357", "species_29438", "Q22038", "WBGene00004357", "species_29438", "O45611", "WBGene00010374" ] }, "reaction_10564769": { "compartment": "compartment_70101", "id": "reaction_10564769", "reactome": "R-CEL-8848818", "name": "PTK6 phosphorylates CBL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10512267", "species_113592" ], "products": [ "species_10528460", "species_29370" ], "modifiers": [ [ "species_10564606", "catalyst" ] ], "additional_components": [ "WBGene00004829", "WBGene00004829", "A0A0K3ARA3", "WBGene00020106", "Q10925", "WBGene00002207" ] }, "reaction_10564784": { "compartment": "compartment_70101", "id": "reaction_10564784", "reactome": "R-CEL-8848864", "name": "PTK6 binds ARAP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10564606", "species_10564780" ], "products": [ "species_10564782" ], "modifiers": [], "additional_components": [ "A0A0K3ARA3", "WBGene00020106", "Q10925", "WBGene00002207", "WBGene00017760", "H2KZV4", "WBGene00017760", "A0A0K3ARA3", "WBGene00020106", "Q10925", "WBGene00002207" ] }, "reaction_10564754": { "compartment": "compartment_70101", "id": "reaction_10564754", "reactome": "R-CEL-8848758", "name": "PTK6 phosphorylates AKT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10564733", "species_113592" ], "products": [ "species_10564751", "species_29370" ], "modifiers": [ [ "species_10564733", "catalyst" ] ], "additional_components": [ "G4S4W1", "WBGene00016980", "Q17941", "WBGene00000102", "Q9XTG7", "WBGene00000103", "A0A0K3ARA3", "WBGene00020106", "Q10925", "WBGene00002207", "G4S4W1", "WBGene00016980", "Q17941", "WBGene00000102", "Q9XTG7", "WBGene00000103", "A0A0K3ARA3", "WBGene00020106", "Q10925", "WBGene00002207", "G4S4W1", "WBGene00016980", "Q17941", "WBGene00000102", "Q9XTG7", "WBGene00000103", "A0A0K3ARA3", "WBGene00020106", "Q10925", "WBGene00002207" ] }, "reaction_10564775": { "compartment": "compartment_70101", "id": "reaction_10564775", "reactome": "R-CEL-8848829", "name": "CBL autoubiquitinates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10528460", "species_10502375" ], "products": [ "species_10564772" ], "modifiers": [ [ "species_10528460", "catalyst" ] ], "additional_components": [ "WBGene00004829", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "WBGene00004829", "WBGene00004829" ] }, "reaction_10564790": { "compartment": "compartment_70101", "id": "reaction_10564790", "reactome": "R-CEL-8848873", "name": "PTK6 phosphorylates ARAP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10564782", "species_113592" ], "products": [ "species_10564606", "species_29370", "species_10564787" ], "modifiers": [ [ "species_10564782", "catalyst" ] ], "additional_components": [ "H2KZV4", "WBGene00017760", "A0A0K3ARA3", "WBGene00020106", "Q10925", "WBGene00002207", "A0A0K3ARA3", "WBGene00020106", "Q10925", "WBGene00002207", "WBGene00017760", "H2KZV4", "WBGene00017760", "A0A0K3ARA3", "WBGene00020106", "Q10925", "WBGene00002207" ] }, "reaction_10564760": { "compartment": "compartment_70101", "id": "reaction_10564760", "reactome": "R-CEL-8848774", "name": "PTK6 binds DOK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10564606", "species_10564756" ], "products": [ "species_10564758" ], "modifiers": [], "additional_components": [ "A0A0K3ARA3", "WBGene00020106", "Q10925", "WBGene00002207", "WBGene00018819", "E6N0V1", "WBGene00018819", "A0A0K3ARA3", "WBGene00020106", "Q10925", "WBGene00002207" ] }, "reaction_10564735": { "compartment": "compartment_70101", "id": "reaction_10564735", "reactome": "R-CEL-8848751", "name": "PTK6 binds AKT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10564606", "species_10520798" ], "products": [ "species_10564733" ], "modifiers": [], "additional_components": [ "A0A0K3ARA3", "WBGene00020106", "Q10925", "WBGene00002207", "G4S4W1", "WBGene00016980", "Q17941", "WBGene00000102", "Q9XTG7", "WBGene00000103", "G4S4W1", "WBGene00016980", "Q17941", "WBGene00000102", "Q9XTG7", "WBGene00000103", "A0A0K3ARA3", "WBGene00020106", "Q10925", "WBGene00002207" ] }, "reaction_10564766": { "compartment": "compartment_70101", "id": "reaction_10564766", "reactome": "R-CEL-8848776", "name": "PTK6 phosphorylates DOK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10564758" ], "products": [ "species_10564606", "species_10564763", "species_29370" ], "modifiers": [ [ "species_10564758", "catalyst" ] ], "additional_components": [ "E6N0V1", "WBGene00018819", "A0A0K3ARA3", "WBGene00020106", "Q10925", "WBGene00002207", "A0A0K3ARA3", "WBGene00020106", "Q10925", "WBGene00002207", "WBGene00018819", "E6N0V1", "WBGene00018819", "A0A0K3ARA3", "WBGene00020106", "Q10925", "WBGene00002207" ] }, "reaction_10564930": { "compartment": "compartment_7660", "id": "reaction_10564930", "reactome": "R-CEL-8849463", "name": "PTK6 phosphorylates SFPQ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10564924" ], "products": [ "species_113582", "species_10564927" ], "modifiers": [ [ "species_10564796", "catalyst" ] ], "additional_components": [ "WBGene00017778", "WBGene00017778", "A0A0K3ARA3", "WBGene00020106", "Q10925", "WBGene00002207" ] }, "reaction_10564798": { "compartment": "compartment_70101", "id": "reaction_10564798", "reactome": "R-CEL-8848930", "name": "PTK6 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10564606" ], "products": [ "species_10564796" ], "modifiers": [], "additional_components": [ "A0A0K3ARA3", "WBGene00020106", "Q10925", "WBGene00002207", "A0A0K3ARA3", "WBGene00020106", "Q10925", "WBGene00002207" ] }, "reaction_10564828": { "compartment": "compartment_70101", "id": "reaction_10564828", "reactome": "R-CEL-8849102", "name": "SRMS phosphorylates PTK6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10564606", "species_113592" ], "products": [ "species_29370", "species_10564823" ], "modifiers": [ [ "species_10564825", "catalyst" ] ], "additional_components": [ "A0A0K3ARA3", "WBGene00020106", "Q10925", "WBGene00002207", "A0A0K3ARA3", "WBGene00020106", "Q10925", "WBGene00002207", "WBGene00020106" ] }, "reaction_10564610": { "compartment": "compartment_70101", "id": "reaction_10564610", "reactome": "R-CEL-8848110", "name": "SOCS3 binds activated PTK6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10564606", "species_10531061" ], "products": [ "species_10564608" ], "modifiers": [], "additional_components": [ "A0A0K3ARA3", "WBGene00020106", "Q10925", "WBGene00002207", "WBGene00009556", "O45498", "WBGene00009556", "A0A0K3ARA3", "WBGene00020106", "Q10925", "WBGene00002207" ] }, "reaction_10515265": { "compartment": "compartment_947587", "id": "reaction_10515265", "reactome": "R-CEL-202626", "name": "I-Smad competes with Co-Smad for R-Smad1/5/8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10515259", "species_10514789" ], "products": [ "species_10515263" ], "modifiers": [], "additional_components": [ "WBGene00006445", "Q02330", "WBGene00004856", "F5GUE5", "WBGene00000910", "P45896", "WBGene00004857", "Q02330", "WBGene00004856", "F5GUE5", "WBGene00000910", "P45896", "WBGene00004857", "G5EDS9", "WBGene00006445" ] }, "reaction_10514817": { "compartment": "compartment_7660", "id": "reaction_10514817", "reactome": "R-CEL-201425", "name": "Ubiquitin-dependent degradation of the Smad complex terminates BMP2 signalling", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10514815" ], "products": [], "modifiers": [ [ "species_10511544", "catalyst" ] ], "additional_components": [ "P45897", "WBGene00004858", "F5GUE5", "WBGene00000910", "P45896", "WBGene00004857", "Q02330", "WBGene00004856", "P35129", "WBGene00002344", "P91853", "WBGene00006732", "Q17720", "WBGene00006717", "Q20617", "WBGene00006719" ] }, "reaction_10514839": { "compartment": "compartment_13231", "id": "reaction_10514839", "reactome": "R-CEL-201472", "name": "The phospho-R-Smad1/5/8:Co-Smad transfers to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10514791" ], "products": [ "species_10514815" ], "modifiers": [], "additional_components": [ "Q02330", "WBGene00004856", "F5GUE5", "WBGene00000910", "P45896", "WBGene00004857", "P45897", "WBGene00004858", "P45897", "WBGene00004858", "F5GUE5", "WBGene00000910", "P45896", "WBGene00004857", "Q02330", "WBGene00004856" ] }, "reaction_10514793": { "compartment": "compartment_70101", "id": "reaction_10514793", "reactome": "R-CEL-201422", "name": "Phospho-R-Smad1/5/8 forms a complex with Co-Smad", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10511404", "species_10514789" ], "products": [ "species_10514791" ], "modifiers": [], "additional_components": [ "WBGene00004858", "Q02330", "WBGene00004856", "F5GUE5", "WBGene00000910", "P45896", "WBGene00004857", "Q02330", "WBGene00004856", "F5GUE5", "WBGene00000910", "P45896", "WBGene00004857", "P45897", "WBGene00004858" ] }, "reaction_10571958": { "compartment": "compartment_13231", "id": "reaction_10571958", "reactome": "R-CEL-9604308", "name": "NICD4 traffics to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10571948" ], "products": [ "species_10517150" ], "modifiers": [ [ "species_10571956", "inhibitor" ] ], "additional_components": [ "WBGene00019957", "WBGene00019957", "Q21850", "WBGene00019957", "Q20655", "WBGene00001502", "P41932", "WBGene00003920" ] }, "reaction_10571961": { "compartment": "compartment_70101", "id": "reaction_10571961", "reactome": "R-CEL-9604328", "name": "AKT1 phosphorylates NOTCH4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10571948", "species_113592" ], "products": [ "species_29370", "species_10571954" ], "modifiers": [ [ "species_10513843", "catalyst" ] ], "additional_components": [ "WBGene00019957", "WBGene00019957", "Q9XTG7", "WBGene00000103", "G4S4W1", "WBGene00016980", "Q17941", "WBGene00000102" ] }, "reaction_10546960": { "compartment": "compartment_20699", "id": "reaction_10546960", "reactome": "R-CEL-3247844", "name": "WNT ligands traffic to the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546918" ], "products": [ "species_10546940" ], "modifiers": [], "additional_components": [ "P34888", "WBGene00000857", "P34889", "WBGene00000858", "Q7YWX7", "WBGene00003246", "Q7YWX7", "WBGene00003246", "P34888", "WBGene00000857", "P34889", "WBGene00000858" ] }, "reaction_10548112": { "compartment": "compartment_876", "id": "reaction_10548112", "reactome": "R-CEL-3781943", "name": "WLS:WNT complex is internalized for maturation into exosomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546940" ], "products": [ "species_10548088" ], "modifiers": [], "additional_components": [ "Q7YWX7", "WBGene00003246", "P34888", "WBGene00000857", "P34889", "WBGene00000858", "Q7YWX7", "WBGene00003246", "P34888", "WBGene00000857", "P34889", "WBGene00000858" ] }, "reaction_10546848": { "compartment": "compartment_20699", "id": "reaction_10546848", "reactome": "R-CEL-3247836", "name": "Retromer recycles WLS to the Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546842" ], "products": [ "species_10546846" ], "modifiers": [], "additional_components": [ "Q7YWX7", "WBGene00003246", "Q9XW41", "WBGene00006503", "O01258", "WBGene00006931", "Q86D99", "WBGene00014234", "Q21053", "WBGene00006933", "Q9XW41", "WBGene00006503", "Q7YWX7", "WBGene00003246", "O01258", "WBGene00006931", "Q86D99", "WBGene00014234", "Q21053", "WBGene00006933" ] }, "reaction_10546913": { "compartment": "compartment_17963", "id": "reaction_10546913", "reactome": "R-CEL-3247837", "name": "WNT ligands traffic to the Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546890" ], "products": [ "species_10546906" ], "modifiers": [ [ "species_10546911", "catalyst" ] ], "additional_components": [ "P34888", "WBGene00000857", "P34889", "WBGene00000858", "P34888", "WBGene00000857", "P34889", "WBGene00000858", "WBGene00010670" ] }, "reaction_10546962": { "compartment": "compartment_171062", "id": "reaction_10546962", "reactome": "R-CEL-3247847", "name": "WLS is endocytosed to the early endosome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546922" ], "products": [ "species_10546835" ], "modifiers": [], "additional_components": [ "WBGene00003246", "WBGene00003246" ] }, "reaction_10546916": { "compartment": "compartment_171062", "id": "reaction_10546916", "reactome": "R-CEL-3247839", "name": "Retromer associates with WLS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546830", "species_10546840", "species_10546835" ], "products": [ "species_10546842" ], "modifiers": [], "additional_components": [ "O01258", "WBGene00006931", "Q86D99", "WBGene00014234", "Q21053", "WBGene00006933", "WBGene00006503", "WBGene00003246", "Q7YWX7", "WBGene00003246", "Q9XW41", "WBGene00006503", "O01258", "WBGene00006931", "Q86D99", "WBGene00014234", "Q21053", "WBGene00006933" ] }, "reaction_10546964": { "compartment": "compartment_20699", "id": "reaction_10546964", "reactome": "R-CEL-3247849", "name": "WLS dissociates from retromer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546846" ], "products": [ "species_10546830", "species_10546844", "species_10546840" ], "modifiers": [], "additional_components": [ "Q9XW41", "WBGene00006503", "Q7YWX7", "WBGene00003246", "O01258", "WBGene00006931", "Q86D99", "WBGene00014234", "Q21053", "WBGene00006933", "O01258", "WBGene00006931", "Q86D99", "WBGene00014234", "Q21053", "WBGene00006933", "WBGene00003246", "WBGene00006503" ] }, "reaction_10546920": { "compartment": "compartment_20699", "id": "reaction_10546920", "reactome": "R-CEL-3247840", "name": "WLS binds WNT ligands in the Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546844", "species_10546906" ], "products": [ "species_10546918" ], "modifiers": [], "additional_components": [ "WBGene00003246", "P34888", "WBGene00000857", "P34889", "WBGene00000858", "P34888", "WBGene00000857", "P34889", "WBGene00000858", "Q7YWX7", "WBGene00003246" ] }, "reaction_10548110": { "compartment": "compartment_383505", "id": "reaction_10548110", "reactome": "R-CEL-3781941", "name": "WNTs are secreted in exosomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10548088" ], "products": [ "species_10548108" ], "modifiers": [], "additional_components": [ "Q7YWX7", "WBGene00003246", "P34888", "WBGene00000857", "P34889", "WBGene00000858", "Q7YWX7", "WBGene00003246", "P34888", "WBGene00000857", "P34889", "WBGene00000858" ] }, "reaction_10546958": { "compartment": "compartment_984", "id": "reaction_10546958", "reactome": "R-CEL-3247843", "name": "secretion of WNT ligands", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546940" ], "products": [ "species_10546956", "species_10546922" ], "modifiers": [], "additional_components": [ "Q7YWX7", "WBGene00003246", "P34888", "WBGene00000857", "P34889", "WBGene00000858", "Q27886", "WBGene00003029", "Q10459", "WBGene00003395", "G5EG05", "WBGene00001188", "P34888", "WBGene00000857", "P34889", "WBGene00000858", "WBGene00003246" ] }, "reaction_10549441": { "compartment": "compartment_70101", "id": "reaction_10549441", "reactome": "R-CEL-4641159", "name": "DVL1 is ubiquitinated by HECW1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10549434", "species_10502375" ], "products": [ "species_10549438" ], "modifiers": [ [ "species_10549434", "catalyst" ] ], "additional_components": [ "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "Q09291", "WBGene00009738", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "A0A0K3AUI8", "C34F11.9e", "Q09291", "WBGene00009738", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "Q09291", "WBGene00009738" ] }, "reaction_10549445": { "compartment": "compartment_70101", "id": "reaction_10549445", "reactome": "R-CEL-4641260", "name": "Ubiquitinated DVL1 is degraded by the proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10549438" ], "products": [ "species_10549432", "species_10502375" ], "modifiers": [ [ "species_10502572", "catalyst" ] ], "additional_components": [ "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "A0A0K3AUI8", "C34F11.9e", "Q09291", "WBGene00009738", "WBGene00009738", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "P91477", "WBGene00003950", "Q95PZ7", "WBGene00013435", "Q18115", "WBGene00004459", "O62102", "WBGene00003948", "O17071", "WBGene00004504", "Q10920", "WBGene00016623", "P34286", "WBGene00003952", "Q9XTT9", "WBGene00004506", "Q23449", "WBGene00004468", "Q95005", "WBGene00003925", "P46502", "WBGene00004503", "O61792", "WBGene00004464", "O17586", "WBGene00003922", "O76371", "WBGene00004505", "Q20585", "WBGene00004463", "Q95008", "WBGene00003926", "Q18787", "WBGene00004501", "Q20058", "WBGene00009445", "Q9N599", "WBGene00003924", "O16368", "WBGene00004502", "O61742", "WBGene00004466", "Q09583", "WBGene00003928", "Q966I8", "WBGene00003947", "Q04908", "WBGene00004460", "Q9XUV0", "WBGene00003951", "Q27488", "WBGene00003923", "Q9GZH5", "WBGene00004458", "O44156", "WBGene00003927", "Q22253", "WBGene00004465", "O76577", "WBGene00004467", "P90868", "WBGene00003953", "Q19324", "WBGene00004461", "Q17971", "WBGene00007588", "Q23237", "WBGene00003949", "Q20938", "WBGene00004462" ] }, "reaction_10535195": { "compartment": "compartment_70101", "id": "reaction_10535195", "reactome": "R-CEL-1504190", "name": "DVL is ubiquitinated by CUL3:KLHL12:RBX1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10535167", "species_10502375" ], "products": [ "species_10535192" ], "modifiers": [ [ "species_10535167", "catalyst" ] ], "additional_components": [ "Q23457", "WBGene00004320", "Q17391", "WBGene00000838", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "Q23457", "WBGene00004320", "Q17391", "WBGene00000838", "Q23457", "WBGene00004320", "Q17391", "WBGene00000838", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241" ] }, "reaction_10549436": { "compartment": "compartment_70101", "id": "reaction_10549436", "reactome": "R-CEL-4641155", "name": "DVL1 is bound by the HECT ubiquitin ligase HECW1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10549432", "species_10515040" ], "products": [ "species_10549434" ], "modifiers": [], "additional_components": [ "WBGene00009738", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "Q09291", "WBGene00009738" ] }, "reaction_10547556": { "compartment": "compartment_7660", "id": "reaction_10547556", "reactome": "R-CEL-3364026", "name": "SET1 complex trimethylates H3K4 at the MYC gene", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10547529" ], "products": [ "species_77502", "species_10547533" ], "modifiers": [ [ "species_10547553", "catalyst" ] ], "additional_components": [ "P62784", "WBGene00001875", "P62784", "WBGene00001875", "G5EFZ3", "WBGene00012458", "Q10666", "WBGene00004077", "Q09309", "WBGene00017683", "O44326", "WBGene00001979", "G5EGI1", "WBGene00011729", "O44447", "WBGene00015330" ] }, "reaction_10547174": { "compartment": "compartment_7660", "id": "reaction_10547174", "reactome": "R-CEL-3299569", "name": "Beta-catenin displaces TLE:HDAC1 from TCF/LEF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10514938", "species_10547170" ], "products": [ "species_10547166", "species_10532119", "species_10547172" ], "modifiers": [], "additional_components": [ "WBGene00001979", "G5ECH0", "WBGene00001836", "O02482", "WBGene00006773", "Q10666", "WBGene00004077", "O02482", "WBGene00006773", "WBGene00001836", "Q10666", "WBGene00004077", "O44326", "WBGene00001979" ] }, "reaction_10547387": { "compartment": "compartment_7660", "id": "reaction_10547387", "reactome": "R-CEL-3322424", "name": "Beta-catenin recruits CDC73 and LEO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509311", "species_10509321", "species_10547172" ], "products": [ "species_10547385" ], "modifiers": [], "additional_components": [ "WBGene00018064", "WBGene00007110", "Q10666", "WBGene00004077", "O44326", "WBGene00001979", "Q10666", "WBGene00004077", "O44326", "WBGene00001979", "Q17431", "WBGene00007110", "Q9N5U5", "WBGene00018064" ] }, "reaction_10547391": { "compartment": "compartment_7660", "id": "reaction_10547391", "reactome": "R-CEL-3322427", "name": "Beta-catenin recruits CBP/p300", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10547172", "species_10532226" ], "products": [ "species_10547389" ], "modifiers": [], "additional_components": [ "Q10666", "WBGene00004077", "O44326", "WBGene00001979", "WBGene00000366", "P34545", "WBGene00000366", "Q10666", "WBGene00004077", "O44326", "WBGene00001979" ] }, "reaction_10514940": { "compartment": "compartment_70101", "id": "reaction_10514940", "reactome": "R-CEL-201669", "name": "Beta-catenin translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10513633" ], "products": [ "species_10514938" ], "modifiers": [], "additional_components": [ "WBGene00001979", "WBGene00001979" ] }, "reaction_10553858": { "compartment": "compartment_7660", "id": "reaction_10553858", "reactome": "R-CEL-5626938", "name": "Beta-catenin binds SOX proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10553854", "species_10514938" ], "products": [ "species_10553856" ], "modifiers": [], "additional_components": [ "Q8T3B9", "WBGene00004771", "A0A1N7SZG1", "WBGene00015716", "Q20201", "WBGene00004950", "Q21305", "WBGene00004949", "Q23045", "WBGene00001182", "WBGene00001979", "O44326", "WBGene00001979", "Q8T3B9", "WBGene00004771", "A0A1N7SZG1", "WBGene00015716", "Q20201", "WBGene00004950", "Q21305", "WBGene00004949", "Q23045", "WBGene00001182" ] }, "reaction_10554594": { "compartment": "compartment_7660", "id": "reaction_10554594", "reactome": "R-CEL-5665608", "name": "TCF:Beta-catenin binds SOX proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10554590", "species_10547172" ], "products": [ "species_10554592" ], "modifiers": [], "additional_components": [ "Q8T3B9", "WBGene00004771", "A0A1N7SZG1", "WBGene00015716", "Q20201", "WBGene00004950", "Q21305", "WBGene00004949", "Q23045", "WBGene00001182", "Q10666", "WBGene00004077", "O44326", "WBGene00001979", "Q10666", "WBGene00004077", "O44326", "WBGene00001979", "Q8T3B9", "WBGene00004771", "A0A1N7SZG1", "WBGene00015716", "Q20201", "WBGene00004950", "Q21305", "WBGene00004949", "Q23045", "WBGene00001182" ] }, "reaction_10547479": { "compartment": "compartment_7660", "id": "reaction_10547479", "reactome": "R-CEL-3361751", "name": "beta-catenin is replaced by repression complexes at the promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10547475", "species_10547473" ], "products": [ "species_10547477", "species_10547170" ], "modifiers": [], "additional_components": [ "O02482", "WBGene00006773", "G5ECH0", "WBGene00001836", "Q10666", "WBGene00004077", "O44326", "WBGene00001979", "Q21227", "WBGene00000156", "Q20595", "WBGene00006424", "O44326", "WBGene00001979", "Q21227", "WBGene00000156", "Q20595", "WBGene00006424", "G5ECH0", "WBGene00001836", "O02482", "WBGene00006773", "Q10666", "WBGene00004077" ] }, "reaction_10547948": { "compartment": "compartment_70101", "id": "reaction_10547948", "reactome": "R-CEL-3769392", "name": "YWHAZ and XPO1 mediate the nuclear export of beta-catenin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10547940" ], "products": [ "species_10547946" ], "modifiers": [], "additional_components": [ "Q23089", "WBGene00002078", "O44326", "WBGene00001979", "Q20655", "WBGene00001502", "P41932", "WBGene00003920", "O44326", "WBGene00001979", "Q20655", "WBGene00001502", "P41932", "WBGene00003920", "Q23089", "WBGene00002078" ] }, "reaction_10551790": { "compartment": "compartment_7660", "id": "reaction_10551790", "reactome": "R-CEL-5368580", "name": "CHD8 binds beta-catenin to negatively regulate WNT-dependent gene expression", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10551786", "species_10514938" ], "products": [ "species_10551788" ], "modifiers": [], "additional_components": [ "WBGene00007053", "WBGene00001979", "O44326", "WBGene00001979", "O61845", "WBGene00007053" ] }, "reaction_10524625": { "compartment": "compartment_876", "id": "reaction_10524625", "reactome": "R-CEL-444393", "name": "RhCG mediates ammonium influx into kidney collecting duct cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_140912" ], "products": [ "species_351626", "species_31633" ], "modifiers": [ [ "species_10524622", "catalyst" ] ], "additional_components": [ "Q17463", "WBGene00004359", "Q22947", "WBGene00004358" ] }, "reaction_10525188": { "compartment": "compartment_876", "id": "reaction_10525188", "reactome": "R-CEL-446277", "name": "RhCG mediates ammonium efflux out of kidney collecting duct cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_31633" ], "products": [ "species_70106", "species_140912" ], "modifiers": [ [ "species_10524622", "catalyst" ] ], "additional_components": [ "Q17463", "WBGene00004359", "Q22947", "WBGene00004358" ] }, "reaction_10525190": { "compartment": "compartment_876", "id": "reaction_10525190", "reactome": "R-CEL-446278", "name": "RhBG mediates ammonium influx into kidney collecting duct cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_140912" ], "products": [ "species_351626", "species_31633" ], "modifiers": [ [ "species_10524636", "catalyst" ] ], "additional_components": [ "WBGene00004358" ] }, "reaction_10524634": { "compartment": "compartment_876", "id": "reaction_10524634", "reactome": "R-CEL-444416", "name": "RHAG transports NH4+ from cytosol to extracellular region (red blood cells)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_31633" ], "products": [ "species_140912" ], "modifiers": [ [ "species_10524631", "catalyst" ] ], "additional_components": [ "Q17463", "WBGene00004359", "Q22947", "WBGene00004358" ] }, "reaction_10524639": { "compartment": "compartment_876", "id": "reaction_10524639", "reactome": "R-CEL-444419", "name": "RhBG mediates ammonium effflux out of kidney collecting duct cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_31633" ], "products": [ "species_70106", "species_140912" ], "modifiers": [ [ "species_10524636", "catalyst" ] ], "additional_components": [ "WBGene00004358" ] }, "reaction_10524112": { "compartment": "compartment_876", "id": "reaction_10524112", "reactome": "R-CEL-433101", "name": "NaDC3 co-transports the dicarboxylic acid succinate and three sodium ion", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_433123", "species_74113" ], "products": [ "species_29434", "species_83910" ], "modifiers": [ [ "species_10524109", "catalyst" ] ], "additional_components": [ "P32739", "WBGene00003518", "P46556", "WBGene00007138", "Q21339", "WBGene00003519", "Q93655", "WBGene00003517" ] }, "reaction_10524130": { "compartment": "compartment_876", "id": "reaction_10524130", "reactome": "R-CEL-433114", "name": "NaS1 co-transports sulphate and a sodium ion", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_427648", "species_74113" ], "products": [ "species_83910", "species_174375" ], "modifiers": [ [ "species_10524127", "catalyst" ] ], "additional_components": [ "P32739", "WBGene00003518", "P46556", "WBGene00007138", "Q21339", "WBGene00003519", "Q93655", "WBGene00003517" ] }, "reaction_10524099": { "compartment": "compartment_876", "id": "reaction_10524099", "reactome": "R-CEL-433099", "name": "NaS2 co-transports sulphate and two sodium ions", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_427648", "species_74113" ], "products": [ "species_83910", "species_174375" ], "modifiers": [ [ "species_10524096", "catalyst" ] ], "additional_components": [ "P46556", "WBGene00007138", "Q21339", "WBGene00003519", "Q93655", "WBGene00003517", "P32739", "WBGene00003518" ] }, "reaction_10524117": { "compartment": "compartment_876", "id": "reaction_10524117", "reactome": "R-CEL-433104", "name": "NACT co-transports trivalent citrate and a sodium ion", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_433138", "species_74113" ], "products": [ "species_76190", "species_83910" ], "modifiers": [ [ "species_10524114", "catalyst" ] ], "additional_components": [ "WBGene00003517" ] }, "reaction_10524143": { "compartment": "compartment_876", "id": "reaction_10524143", "reactome": "R-CEL-433131", "name": "NaDC1 co-transports dicarboxylic acids and a sodium ion", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_433111", "species_74113" ], "products": [ "species_83910", "species_433124" ], "modifiers": [ [ "species_10524140", "catalyst" ] ], "additional_components": [ "species_76190", "species_1650769", "species_1650769", "species_76190", "P32739", "WBGene00003518", "P46556", "WBGene00007138", "Q21339", "WBGene00003519", "Q93655", "WBGene00003517" ] }, "reaction_10523391": { "compartment": "compartment_876", "id": "reaction_10523391", "reactome": "R-CEL-429101", "name": "HMIT co-transports myo-inositol with a proton", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_429130" ], "products": [ "species_70106", "species_426910" ], "modifiers": [ [ "species_10523388", "catalyst" ] ], "additional_components": [ "WBGene00010811" ] }, "reaction_10524074": { "compartment": "compartment_876", "id": "reaction_10524074", "reactome": "R-CEL-433089", "name": "SOAT can transport taurolithocholate-3-sulphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_433120", "species_74113" ], "products": [ "species_83910", "species_176483" ], "modifiers": [ [ "species_10524071", "catalyst" ] ], "additional_components": [ "WBGene00044650" ] }, "reaction_10524593": { "compartment": "compartment_876", "id": "reaction_10524593", "reactome": "R-CEL-444160", "name": "VMAT1/2 can mediate the transport of biogenic amines", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_444154" ], "products": [ "species_444152" ], "modifiers": [ [ "species_10524590", "catalyst" ] ], "additional_components": [ "species_351601", "species_209794", "species_380585", "species_390899", "species_209789", "species_209789", "species_209794", "species_390899", "species_351601", "species_380585", "WBGene00000295" ] }, "reaction_10524580": { "compartment": "compartment_876", "id": "reaction_10524580", "reactome": "R-CEL-443997", "name": "SLC6A2 cotransports NAd, Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_374935", "species_74113" ], "products": [ "species_209789", "species_83910" ], "modifiers": [ [ "species_10524577", "catalyst" ] ], "additional_components": [ "WBGene00000934" ] }, "reaction_10518791": { "compartment": "compartment_876", "id": "reaction_10518791", "reactome": "R-CEL-374896", "name": "Uptake of Noradrenaline", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_374935" ], "products": [ "species_209789" ], "modifiers": [ [ "species_10518786", "catalyst" ] ], "additional_components": [ "WBGene00003987" ] }, "reaction_10524651": { "compartment": "compartment_984", "id": "reaction_10524651", "reactome": "R-CEL-444433", "name": "Cho transports from the extracellular space to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_264638" ], "products": [ "species_264618" ], "modifiers": [ [ "species_10524644", "catalyst" ] ], "additional_components": [ "WBGene00018037" ] }, "reaction_10527456": { "compartment": "compartment_876", "id": "reaction_10527456", "reactome": "R-CEL-549304", "name": "OCT3 mediates renal clearance of organic cations", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_549326" ], "products": [ "species_549255" ], "modifiers": [ [ "species_10527453", "catalyst" ] ], "additional_components": [ "CHEBI:8428", "CHEBI:46020", "CHEBI:42820", "CHEBI:47499", "CHEBI:47781", "CHEBI:641", "CHEBI:46631", "CHEBI:47781", "CHEBI:8428", "CHEBI:42820", "CHEBI:47499", "CHEBI:641", "CHEBI:46020", "CHEBI:46631", "WBGene00003987" ] }, "reaction_10527408": { "compartment": "compartment_876", "id": "reaction_10527408", "reactome": "R-CEL-549241", "name": "SLC22A4 cotransports ERGT, Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_549261", "species_74113" ], "products": [ "species_83910", "species_549260" ], "modifiers": [ [ "species_10527400", "catalyst" ], [ "species_10527406", "inhibitor" ] ], "additional_components": [ "Q4PIX1", "WBGene00044455", "Q9BKR9", "WBGene00044455", "Q9U539", "WBGene00003842", "Q9UAW9", "WBGene00044455", "A0A0K3AWD3", "WBGene00044455", "A0A238UKL7", "WBGene00044455", "G5EEI9", "WBGene00044455", "G5EGL6", "WBGene00044455", "O18247", "WBGene00044455", "P46499", "WBGene00044455", "Q09617", "WBGene00044455", "Q18613", "WBGene00044455", "Q18655", "WBGene00044455", "Q18795", "WBGene00008271", "Q23501", "WBGene00003843", "WBGene00004393" ] }, "reaction_10527537": { "compartment": "compartment_876", "id": "reaction_10527537", "reactome": "R-CEL-597628", "name": "SLC22A18 exchanges extracellular organic cations for cytosolic H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_597604", "species_70106" ], "products": [ "species_351626", "species_597623" ], "modifiers": [ [ "species_10527534", "catalyst" ] ], "additional_components": [ "WBGene00008273" ] }, "reaction_10527458": { "compartment": "compartment_876", "id": "reaction_10527458", "reactome": "R-CEL-549322", "name": "OCT1 transports organic cations out of hepatic cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_549250" ], "products": [ "species_549264" ], "modifiers": [ [ "species_10518788", "catalyst" ] ], "additional_components": [ "species_351601", "species_209794", "CHEBI:46020", "CHEBI:42820", "CHEBI:6801", "species_549282", "species_6798162", "CHEBI:65133", "CHEBI:15854", "species_141324", "CHEBI:641", "species_390899", "species_353560", "species_209789", "CHEBI:42820", "CHEBI:641", "CHEBI:46020", "species_351601", "CHEBI:6801", "species_209794", "species_141324", "CHEBI:15854", "species_209789", "CHEBI:65133", "species_390899", "species_353560", "species_6798162", "species_549282", "WBGene00003987" ] }, "reaction_10527507": { "compartment": "compartment_876", "id": "reaction_10527507", "reactome": "R-CEL-561072", "name": "OCT3 mediates renal uptake of organic cations", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_549255" ], "products": [ "species_549326" ], "modifiers": [ [ "species_10527453", "catalyst" ] ], "additional_components": [ "CHEBI:47781", "CHEBI:8428", "CHEBI:42820", "CHEBI:47499", "CHEBI:641", "CHEBI:46020", "CHEBI:46631", "CHEBI:8428", "CHEBI:46020", "CHEBI:42820", "CHEBI:47499", "CHEBI:47781", "CHEBI:641", "CHEBI:46631", "WBGene00003987" ] }, "reaction_10527412": { "compartment": "compartment_876", "id": "reaction_10527412", "reactome": "R-CEL-549279", "name": "OCT2 mediates tubular uptake of organic cations in the kidney", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_549237" ], "products": [ "species_549266" ], "modifiers": [ [ "species_10518786", "catalyst" ] ], "additional_components": [ "CHEBI:31941", "CHEBI:16737", "CHEBI:641", "CHEBI:46020", "species_351601", "CHEBI:6801", "species_209794", "species_209789", "CHEBI:65133", "species_351164", "species_390899", "species_6798162", "species_549282", "species_380585", "species_351601", "species_209794", "CHEBI:46020", "CHEBI:6801", "species_549282", "CHEBI:16737", "species_6798162", "CHEBI:65133", "CHEBI:641", "species_380585", "species_351164", "species_390899", "CHEBI:31941", "species_209789", "WBGene00003987" ] }, "reaction_10527494": { "compartment": "compartment_876", "id": "reaction_10527494", "reactome": "R-CEL-561054", "name": "OCT2 mediates tubular secretion of organic cations in the kidney", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_549266" ], "products": [ "species_549237" ], "modifiers": [ [ "species_10518786", "catalyst" ] ], "additional_components": [ "species_351601", "species_209794", "CHEBI:46020", "CHEBI:6801", "species_549282", "CHEBI:16737", "species_6798162", "CHEBI:65133", "CHEBI:641", "species_380585", "species_351164", "species_390899", "CHEBI:31941", "species_209789", "CHEBI:31941", "CHEBI:16737", "CHEBI:641", "CHEBI:46020", "species_351601", "CHEBI:6801", "species_209794", "species_209789", "CHEBI:65133", "species_351164", "species_390899", "species_6798162", "species_549282", "species_380585", "WBGene00003987" ] }, "reaction_10527451": { "compartment": "compartment_876", "id": "reaction_10527451", "reactome": "R-CEL-549297", "name": "SLC22A4, 5,15,16 cotransport CAR, Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_164988", "species_74113" ], "products": [ "species_30235", "species_83910" ], "modifiers": [ [ "species_10527448", "catalyst" ] ], "additional_components": [ "P46499", "WBGene00044455", "Q09617", "WBGene00044455", "Q18613", "WBGene00044455", "Q18655", "WBGene00044455", "Q18795", "WBGene00008271", "Q23501", "WBGene00003843", "Q4PIX1", "WBGene00044455", "Q9BKR9", "WBGene00044455", "Q9U539", "WBGene00003842", "Q9UAW9", "WBGene00044455", "A0A0K3AWD3", "WBGene00044455", "A0A238UKL7", "WBGene00044455", "G5EEI9", "WBGene00044455", "G5EGL6", "WBGene00044455", "O18247", "WBGene00044455" ] }, "reaction_10527343": { "compartment": "compartment_876", "id": "reaction_10527343", "reactome": "R-CEL-549129", "name": "OCT1 transports organic cations into hepatic cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_549264" ], "products": [ "species_549250" ], "modifiers": [ [ "species_10518788", "catalyst" ] ], "additional_components": [ "CHEBI:42820", "CHEBI:641", "CHEBI:46020", "species_351601", "CHEBI:6801", "species_209794", "species_141324", "CHEBI:15854", "species_209789", "CHEBI:65133", "species_390899", "species_353560", "species_6798162", "species_549282", "species_351601", "species_209794", "CHEBI:46020", "CHEBI:42820", "CHEBI:6801", "species_549282", "species_6798162", "CHEBI:65133", "CHEBI:15854", "species_141324", "CHEBI:641", "species_390899", "species_353560", "species_209789", "WBGene00003987" ] }, "reaction_10527505": { "compartment": "compartment_876", "id": "reaction_10527505", "reactome": "R-CEL-561059", "name": "OAT2 and OAT4 mediate transport of sulphate conjugates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29406", "species_561071" ], "products": [ "species_561062", "species_561075" ], "modifiers": [ [ "species_10527502", "catalyst" ] ], "additional_components": [ "species_176496", "species_176501", "species_176501", "species_176496", "Q10917", "WBGene00020701", "Q22686", "WBGene00020701" ] }, "reaction_10527492": { "compartment": "compartment_876", "id": "reaction_10527492", "reactome": "R-CEL-561041", "name": "OAT1-3 transport organic anions with antiport of dicarboxylic acids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29406", "species_561049" ], "products": [ "species_561078", "species_561075" ], "modifiers": [ [ "species_10527489", "catalyst" ] ], "additional_components": [ "CHEBI:104011", "species_561052", "species_561052", "CHEBI:104011", "Q22686", "WBGene00020701", "Q10917", "WBGene00020701" ] }, "reaction_10527516": { "compartment": "compartment_876", "id": "reaction_10527516", "reactome": "R-CEL-561253", "name": "SLC22A12 exchanges extracellular urate for cytosolic LACT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29708", "species_429056" ], "products": [ "species_373863", "species_30034" ], "modifiers": [ [ "species_10527513", "catalyst" ] ], "additional_components": [ "Q10917", "WBGene00020701", "Q22686", "WBGene00020701" ] }, "reaction_10523423": { "compartment": "compartment_876", "id": "reaction_10523423", "reactome": "R-CEL-429594", "name": "SLC5A7 cotransports Cho, Cl-, Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_188972", "species_264638", "species_74113" ], "products": [ "species_264618", "species_83910", "species_352022" ], "modifiers": [ [ "species_10523420", "catalyst" ] ], "additional_components": [ "WBGene00000501" ] }, "reaction_10515237": { "compartment": "compartment_70101", "id": "reaction_10515237", "reactome": "R-CEL-202354", "name": "Translocation of PLC-gamma1 to PIP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10515230", "species_179856" ], "products": [ "species_10515235" ], "modifiers": [], "additional_components": [ "WBGene00004038", "Q22070", "WBGene00004038", "species_179856" ] }, "reaction_10515245": { "compartment": "compartment_70101", "id": "reaction_10515245", "reactome": "R-CEL-202407", "name": "PLC-gamma1 hydrolyses PIP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_179856" ], "products": [ "species_114520", "species_112275" ], "modifiers": [ [ "species_10515242", "catalyst" ] ], "additional_components": [ "WBGene00004038" ] }, "reaction_10529204": { "compartment": "compartment_74700", "id": "reaction_10529204", "reactome": "R-CEL-917841", "name": "Acidification of Tf:TfR1 containing endosome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_70106", "species_113592" ], "products": [ "species_29372", "species_29370", "species_74722" ], "modifiers": [ [ "species_10506845", "catalyst" ] ], "additional_components": [ "G5EGP4", "WBGene00006915", "P30628", "WBGene00006768", "B2MZD0", "WBGene00006916", "G5EEK9", "WBGene00006914", "C0HLB3", "WBGene00006911", "C0HLB4", "WBGene00006912", "G5EDB8", "WBGene00006913", "Q95YD5", "WBGene00016258", "Q20591", "WBGene00009882", "Q9XXU9", "WBGene00006920", "Q22494", "WBGene00020507", "Q23680", "WBGene00006918", "P34462", "WBGene00010130", "Q9XW92", "WBGene00013025", "Q19626", "WBGene00006921", "Q9N5A0", "WBGene00004959", "Q95X44", "WBGene00006917", "P91303", "WBGene00006919", "Q9TYW1", "WBGene00021952" ] }, "reaction_10529221": { "compartment": "compartment_74700", "id": "reaction_10529221", "reactome": "R-CEL-917936", "name": "MCOLN1 transports Fe2+ from endosome lumen to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_917810" ], "products": [ "species_71067" ], "modifiers": [ [ "species_10529218", "catalyst" ] ], "additional_components": [ "WBGene00000846" ] }, "reaction_10543223": { "compartment": "compartment_984", "id": "reaction_10543223", "reactome": "R-CEL-2168886", "name": "Hemopexin binds Hemes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9707310", "species_10543219" ], "products": [ "species_10543221" ], "modifiers": [], "additional_components": [ "species_71185", "Q21182", "WBGene00194737", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "Q21182", "WBGene00194737", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "species_71185" ] }, "reaction_10503456": { "compartment": "compartment_5460", "id": "reaction_10503456", "reactome": "R-CEL-70859", "name": "isobutyryl-CoA + FAD => methacrylyl-CoA + FADH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113596", "species_70851" ], "products": [ "species_70858", "species_31649" ], "modifiers": [ [ "species_10503453", "catalyst" ] ], "additional_components": [ "Q95YB2", "WBGene00017874", "species_113596" ] }, "reaction_10527201": { "compartment": "compartment_70101", "id": "reaction_10527201", "reactome": "R-CEL-508189", "name": "a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29404", "species_508187" ], "products": [ "species_29406", "species_508182" ], "modifiers": [ [ "species_10503361", "catalyst" ] ], "additional_components": [ "CHEBI:28654", "CHEBI:17865", "CHEBI:16530", "CHEBI:57427", "CHEBI:58045", "species_29702", "P54688", "WBGene00001149" ] }, "reaction_10503426": { "compartment": "compartment_5460", "id": "reaction_10503426", "reactome": "R-CEL-70800", "name": "alpha-methylbutyryl-CoA + FAD => tiglyl-CoA + FADH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70718", "species_113596" ], "products": [ "species_70799", "species_31649" ], "modifiers": [ [ "species_10503423", "catalyst" ] ], "additional_components": [ "O44549", "WBGene00019433", "species_113596" ] }, "reaction_10527203": { "compartment": "compartment_5460", "id": "reaction_10527203", "reactome": "R-CEL-508308", "name": "beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O <=> beta-methylcrotonyl-CoA + ATP + CO2 [MCCA]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113548", "species_113581", "species_70772", "species_113521" ], "products": [ "species_70744", "species_29896", "species_113593" ], "modifiers": [ [ "species_10503403", "catalyst" ] ], "additional_components": [ "P34385", "WBGene00303021", "O45430", "WBGene00009319" ] }, "reaction_10503492": { "compartment": "compartment_5460", "id": "reaction_10503492", "reactome": "R-CEL-70893", "name": "methylmalonate semialdehyde + NAD+ + CoA => propionyl-CoA + CO2 + NADH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_113526", "species_30004" ], "products": [ "species_70843", "species_113529", "species_29362", "species_29376" ], "modifiers": [ [ "species_10503489", "catalyst" ] ], "additional_components": [ "WBGene00000114" ] }, "reaction_10556964": { "compartment": "compartment_5460", "id": "reaction_10556964", "reactome": "R-CEL-5693153", "name": "PPM1K dephosphorylates p-BCKDH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10556954", "species_113521" ], "products": [ "species_113548", "species_10503350" ], "modifiers": [ [ "species_10556961", "catalyst" ] ], "additional_components": [ "Q23571", "WBGene00014054", "Q93619", "WBGene00006518", "species_8878387", "O45924", "WBGene00012713", "O17953", "WBGene00010794", "species_113596", "Q23571", "WBGene00014054", "Q93619", "WBGene00006518", "species_8878387", "O45924", "WBGene00012713", "O17953", "WBGene00010794", "species_113596", "species_266099", "G5EEM6", "WBGene00006524" ] }, "reaction_10527205": { "compartment": "compartment_5460", "id": "reaction_10527205", "reactome": "R-CEL-508369", "name": "alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113529", "species_70836", "species_29362" ], "products": [ "species_70829", "species_113526" ], "modifiers": [ [ "species_10503433", "catalyst" ] ], "additional_components": [ "Q19102", "WBGene00000181" ] }, "reaction_10527207": { "compartment": "compartment_5460", "id": "reaction_10527207", "reactome": "R-CEL-508473", "name": "methylmalonyl semialdehyde + NADH + H+ <=> beta-hydroxyisobutyrate + NAD+", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113529", "species_30004", "species_29362" ], "products": [ "species_113526", "species_573404" ], "modifiers": [ [ "species_10503481", "catalyst" ] ], "additional_components": [ "Q9XTI0", "WBGene00007122" ] }, "reaction_10503466": { "compartment": "compartment_5460", "id": "reaction_10503466", "reactome": "R-CEL-70870", "name": "ECHS1 hydrates methacrylyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70858", "species_113521" ], "products": [ "species_71847" ], "modifiers": [ [ "species_10503463", "catalyst" ] ], "additional_components": [ "P34559", "WBGene00001155" ] }, "reaction_10503474": { "compartment": "compartment_5460", "id": "reaction_10503474", "reactome": "R-CEL-70881", "name": "beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71847", "species_113521" ], "products": [ "species_29374", "species_573404" ], "modifiers": [ [ "species_10503471", "catalyst" ] ], "additional_components": [ "WBGene00017301" ] }, "reaction_10503380": { "compartment": "compartment_5460", "id": "reaction_10503380", "reactome": "R-CEL-70724", "name": "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113594", "species_508190" ], "products": [ "species_508181", "species_113552" ], "modifiers": [ [ "species_10503377", "catalyst" ] ], "additional_components": [ "CHEBI:58045", "species_29702", "CHEBI:57427", "CHEBI:16530", "CHEBI:28654", "CHEBI:17865", "P54688", "WBGene00001149", "Q9XXD8", "WBGene00012855" ] }, "reaction_10503446": { "compartment": "compartment_5460", "id": "reaction_10503446", "reactome": "R-CEL-70844", "name": "alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_70836" ], "products": [ "species_70843", "species_113559" ], "modifiers": [ [ "species_10503443", "catalyst" ] ], "additional_components": [ "Q22100", "WBGene00002183" ] }, "reaction_10503416": { "compartment": "compartment_5460", "id": "reaction_10503416", "reactome": "R-CEL-70785", "name": "beta-methylglutaconyl-CoA + H2O <=> beta-hydroxy-beta-methylglutaryl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70772", "species_113521" ], "products": [ "species_70784" ], "modifiers": [ [ "species_10503413", "catalyst" ] ], "additional_components": [ "O45106", "WBGene00001154" ] }, "reaction_10503353": { "compartment": "compartment_5460", "id": "reaction_10503353", "reactome": "R-CEL-70713", "name": "BCKDH transfers CoA group from CoA-SH to BCAAs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_113526", "species_508181" ], "products": [ "species_29362", "species_508261", "species_29376" ], "modifiers": [ [ "species_10503350", "catalyst" ] ], "additional_components": [ "CHEBI:16530", "CHEBI:28654", "CHEBI:17865", "species_70851", "species_70715", "species_70718", "Q23571", "WBGene00014054", "Q93619", "WBGene00006518", "species_8878387", "O45924", "WBGene00012713", "O17953", "WBGene00010794", "species_113596" ] }, "reaction_10503390": { "compartment": "compartment_5460", "id": "reaction_10503390", "reactome": "R-CEL-70745", "name": "isovaleryl-CoA + FAD => beta-methylcrotonyl-CoA + FADH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113596", "species_70715" ], "products": [ "species_70744", "species_31649" ], "modifiers": [ [ "species_10503387", "catalyst" ] ], "additional_components": [ "G5EEH6", "WBGene00015326", "species_113596" ] }, "reaction_10557989": { "compartment": "compartment_7660", "id": "reaction_10557989", "reactome": "R-CEL-6783238", "name": "OTUB1,(OTUB2) binds TP53, UBE2D1, ESR1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10511537", "species_10557985" ], "products": [ "species_10557987" ], "modifiers": [], "additional_components": [ "P35129", "WBGene00002344", "P91853", "WBGene00006732", "Q17720", "WBGene00006717", "Q9XVR6", "WBGene00007718", "Q9XVR6", "WBGene00007718", "P35129", "WBGene00002344", "P91853", "WBGene00006732", "Q17720", "WBGene00006717" ] }, "reaction_10556681": { "compartment": "compartment_70101", "id": "reaction_10556681", "reactome": "R-CEL-5690843", "name": "OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10556669", "species_10556677" ], "products": [ "species_10556679" ], "modifiers": [], "additional_components": [ "Q9XVR6", "WBGene00007718", "Q9XX98", "WBGene00019185", "O76671", "WBGene00019185", "Q22038", "WBGene00004357", "Q9XX98", "WBGene00019185", "O76671", "WBGene00019185", "Q22038", "WBGene00004357", "Q9XVR6", "WBGene00007718" ] }, "reaction_10566184": { "compartment": "compartment_70101", "id": "reaction_10566184", "reactome": "R-CEL-8865182", "name": "OTUD7A hydrolyses K11diUb", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10566176" ], "products": [ "species_10502375" ], "modifiers": [ [ "species_10566181", "catalyst" ] ], "additional_components": [ "P37165", "WBGene00006725", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "WBGene00021733" ] }, "reaction_10554672": { "compartment": "compartment_70101", "id": "reaction_10554672", "reactome": "R-CEL-5665871", "name": "ADRM1 binds 26S proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502572", "species_10554643" ], "products": [ "species_10554645" ], "modifiers": [], "additional_components": [ "P91477", "WBGene00003950", "Q95PZ7", "WBGene00013435", "Q18115", "WBGene00004459", "O62102", "WBGene00003948", "O17071", "WBGene00004504", "Q10920", "WBGene00016623", "P34286", "WBGene00003952", "Q9XTT9", "WBGene00004506", "Q23449", "WBGene00004468", "Q95005", "WBGene00003925", "P46502", "WBGene00004503", "O61792", "WBGene00004464", "O17586", "WBGene00003922", "O76371", "WBGene00004505", "Q20585", "WBGene00004463", "Q95008", "WBGene00003926", "Q18787", "WBGene00004501", "Q20058", "WBGene00009445", "Q9N599", "WBGene00003924", "O16368", "WBGene00004502", "O61742", "WBGene00004466", "Q09583", "WBGene00003928", "Q966I8", "WBGene00003947", "Q04908", "WBGene00004460", "Q9XUV0", "WBGene00003951", "Q27488", "WBGene00003923", "Q9GZH5", "WBGene00004458", "O44156", "WBGene00003927", "Q22253", "WBGene00004465", "O76577", "WBGene00004467", "P90868", "WBGene00003953", "Q19324", "WBGene00004461", "Q17971", "WBGene00007588", "Q23237", "WBGene00003949", "Q20938", "WBGene00004462", "WBGene00016981", "Q09289", "WBGene00016981", "P91477", "WBGene00003950", "Q95PZ7", "WBGene00013435", "Q18115", "WBGene00004459", "O62102", "WBGene00003948", "O17071", "WBGene00004504", "Q10920", "WBGene00016623", "P34286", "WBGene00003952", "Q9XTT9", "WBGene00004506", "Q23449", "WBGene00004468", "Q95005", "WBGene00003925", "P46502", "WBGene00004503", "O61792", "WBGene00004464", "O17586", "WBGene00003922", "O76371", "WBGene00004505", "Q20585", "WBGene00004463", "Q95008", "WBGene00003926", "Q18787", "WBGene00004501", "Q20058", "WBGene00009445", "Q9N599", "WBGene00003924", "O16368", "WBGene00004502", "O61742", "WBGene00004466", "Q09583", "WBGene00003928", "Q966I8", "WBGene00003947", "Q04908", "WBGene00004460", "Q9XUV0", "WBGene00003951", "Q27488", "WBGene00003923", "Q9GZH5", "WBGene00004458", "O44156", "WBGene00003927", "Q22253", "WBGene00004465", "O76577", "WBGene00004467", "P90868", "WBGene00003953", "Q19324", "WBGene00004461", "Q17971", "WBGene00007588", "Q23237", "WBGene00003949", "Q20938", "WBGene00004462" ] }, "reaction_10554649": { "compartment": "compartment_70101", "id": "reaction_10554649", "reactome": "R-CEL-5665854", "name": "ADRM1:26S proteaseome binds UCHL5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10554638", "species_10554645" ], "products": [ "species_10554647" ], "modifiers": [], "additional_components": [ "WBGene00006724", "Q09289", "WBGene00016981", "P91477", "WBGene00003950", "Q95PZ7", "WBGene00013435", "Q18115", "WBGene00004459", "O62102", "WBGene00003948", "O17071", "WBGene00004504", "Q10920", "WBGene00016623", "P34286", "WBGene00003952", "Q9XTT9", "WBGene00004506", "Q23449", "WBGene00004468", "Q95005", "WBGene00003925", "P46502", "WBGene00004503", "O61792", "WBGene00004464", "O17586", "WBGene00003922", "O76371", "WBGene00004505", "Q20585", "WBGene00004463", "Q95008", "WBGene00003926", "Q18787", "WBGene00004501", "Q20058", "WBGene00009445", "Q9N599", "WBGene00003924", "O16368", "WBGene00004502", "O61742", "WBGene00004466", "Q09583", "WBGene00003928", "Q966I8", "WBGene00003947", "Q04908", "WBGene00004460", "Q9XUV0", "WBGene00003951", "Q27488", "WBGene00003923", "Q9GZH5", "WBGene00004458", "O44156", "WBGene00003927", "Q22253", "WBGene00004465", "O76577", "WBGene00004467", "P90868", "WBGene00003953", "Q19324", "WBGene00004461", "Q17971", "WBGene00007588", "Q23237", "WBGene00003949", "Q20938", "WBGene00004462", "Q09289", "WBGene00016981", "P91477", "WBGene00003950", "Q95PZ7", "WBGene00013435", "Q18115", "WBGene00004459", "O62102", "WBGene00003948", "O17071", "WBGene00004504", "Q10920", "WBGene00016623", "P34286", "WBGene00003952", "Q9XTT9", "WBGene00004506", "Q23449", "WBGene00004468", "Q95005", "WBGene00003925", "P46502", "WBGene00004503", "O61792", "WBGene00004464", "O17586", "WBGene00003922", "O76371", "WBGene00004505", "Q20585", "WBGene00004463", "Q95008", "WBGene00003926", "Q18787", "WBGene00004501", "Q20058", "WBGene00009445", "Q9N599", "WBGene00003924", "O16368", "WBGene00004502", "O61742", "WBGene00004466", "Q09583", "WBGene00003928", "Q966I8", "WBGene00003947", "Q04908", "WBGene00004460", "Q9XUV0", "WBGene00003951", "Q27488", "WBGene00003923", "Q9GZH5", "WBGene00004458", "O44156", "WBGene00003927", "Q22253", "WBGene00004465", "O76577", "WBGene00004467", "P90868", "WBGene00003953", "Q19324", "WBGene00004461", "Q17971", "WBGene00007588", "Q23237", "WBGene00003949", "Q20938", "WBGene00004462", "Q09444", "WBGene00006724" ] }, "reaction_10556601": { "compartment": "compartment_70101", "id": "reaction_10556601", "reactome": "R-CEL-5690319", "name": "UCHL1, UCHL3 cleave ubiquitin adducts", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10556596" ], "products": [ "species_1131871", "species_10556598" ], "modifiers": [ [ "species_10556596", "catalyst" ] ], "additional_components": [ "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "P49632", "WBGene00006728", "Q9UAV3", "WBGene00006721", "Q8MNY0", "WBGene00006722", "Q965V9", "WBGene00006723", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "Q9UAV3", "WBGene00006721", "Q8MNY0", "WBGene00006722", "Q965V9", "WBGene00006723", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "P49632", "WBGene00006728", "Q9UAV3", "WBGene00006721", "Q8MNY0", "WBGene00006722", "Q965V9", "WBGene00006723" ] }, "reaction_10556653": { "compartment": "compartment_70101", "id": "reaction_10556653", "reactome": "R-CEL-5690808", "name": "UCHL3, SENP8 cleave NEDD8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10556644" ], "products": [ "species_10556650", "species_10556648" ], "modifiers": [ [ "species_10556644", "catalyst" ] ], "additional_components": [ "Q93725", "WBGene00003587", "Q9UAV3", "WBGene00006721", "Q86FN3", "WBGene00006738", "WBGene00003587", "Q93725", "WBGene00003587", "Q9UAV3", "WBGene00006721", "Q86FN3", "WBGene00006738", "Q93725", "WBGene00003587", "Q9UAV3", "WBGene00006721", "Q86FN3", "WBGene00006738" ] }, "reaction_10556465": { "compartment": "compartment_7660", "id": "reaction_10556465", "reactome": "R-CEL-5689950", "name": "USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10556179" ], "products": [ "species_10556462", "species_10556185" ], "modifiers": [ [ "species_10556179", "catalyst" ] ], "additional_components": [ "O16850", "WBGene00000912", "G5EE01", "WBGene00000913", "Q7JKC3", "WBGene00010406", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "P49632", "WBGene00006728", "G5EE01", "WBGene00000913", "O16850", "WBGene00000912", "Q7JKC3", "WBGene00010406", "O16850", "WBGene00000912", "G5EE01", "WBGene00000913", "Q7JKC3", "WBGene00010406" ] }, "reaction_10557760": { "compartment": "compartment_7660", "id": "reaction_10557760", "reactome": "R-CEL-5696960", "name": "USP49 deubiquitinates H2B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10557755" ], "products": [ "species_10502318", "species_10557757" ], "modifiers": [ [ "species_10557755", "catalyst" ] ], "additional_components": [ "Q9GRV2", "WBGene00013506", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "Q9GRV2", "WBGene00013506", "Q9GRV2", "WBGene00013506" ] }, "reaction_10557827": { "compartment": "compartment_70101", "id": "reaction_10557827", "reactome": "R-CEL-6781764", "name": "USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10557820", "species_29356" ], "products": [ "species_10502375", "species_10557824" ], "modifiers": [ [ "species_10557820", "catalyst" ] ], "additional_components": [ "Q8WT44", "WBGene00000874", "V6CJY2", "WBGene00019259", "Q02330", "WBGene00004856", "F5GUE5", "WBGene00000910", "P45896", "WBGene00004857", "Q21733", "WBGene00000904", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "Q8WT44", "WBGene00000874", "V6CJY2", "WBGene00019259", "Q21733", "WBGene00000904", "F5GUE5", "WBGene00000910", "P45896", "WBGene00004857", "Q02330", "WBGene00004856", "Q8WT44", "WBGene00000874", "V6CJY2", "WBGene00019259", "Q02330", "WBGene00004856", "F5GUE5", "WBGene00000910", "P45896", "WBGene00004857", "Q21733", "WBGene00000904" ] }, "reaction_10556130": { "compartment": "compartment_70101", "id": "reaction_10556130", "reactome": "R-CEL-5689539", "name": "ADRM1:26S proteaseome binds USP14", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10556126", "species_10554645" ], "products": [ "species_10556128" ], "modifiers": [], "additional_components": [ "WBGene00006856", "Q09289", "WBGene00016981", "P91477", "WBGene00003950", "Q95PZ7", "WBGene00013435", "Q18115", "WBGene00004459", "O62102", "WBGene00003948", "O17071", "WBGene00004504", "Q10920", "WBGene00016623", "P34286", "WBGene00003952", "Q9XTT9", "WBGene00004506", "Q23449", "WBGene00004468", "Q95005", "WBGene00003925", "P46502", "WBGene00004503", "O61792", "WBGene00004464", "O17586", "WBGene00003922", "O76371", "WBGene00004505", "Q20585", "WBGene00004463", "Q95008", "WBGene00003926", "Q18787", "WBGene00004501", "Q20058", "WBGene00009445", "Q9N599", "WBGene00003924", "O16368", "WBGene00004502", "O61742", "WBGene00004466", "Q09583", "WBGene00003928", "Q966I8", "WBGene00003947", "Q04908", "WBGene00004460", "Q9XUV0", "WBGene00003951", "Q27488", "WBGene00003923", "Q9GZH5", "WBGene00004458", "O44156", "WBGene00003927", "Q22253", "WBGene00004465", "O76577", "WBGene00004467", "P90868", "WBGene00003953", "Q19324", "WBGene00004461", "Q17971", "WBGene00007588", "Q23237", "WBGene00003949", "Q20938", "WBGene00004462", "Q09289", "WBGene00016981", "P91477", "WBGene00003950", "Q95PZ7", "WBGene00013435", "Q18115", "WBGene00004459", "O62102", "WBGene00003948", "O17071", "WBGene00004504", "Q10920", "WBGene00016623", "P34286", "WBGene00003952", "Q9XTT9", "WBGene00004506", "Q23449", "WBGene00004468", "Q95005", "WBGene00003925", "P46502", "WBGene00004503", "O61792", "WBGene00004464", "O17586", "WBGene00003922", "O76371", "WBGene00004505", "Q20585", "WBGene00004463", "Q95008", "WBGene00003926", "Q18787", "WBGene00004501", "Q20058", "WBGene00009445", "Q9N599", "WBGene00003924", "O16368", "WBGene00004502", "O61742", "WBGene00004466", "Q09583", "WBGene00003928", "Q966I8", "WBGene00003947", "Q04908", "WBGene00004460", "Q9XUV0", "WBGene00003951", "Q27488", "WBGene00003923", "Q9GZH5", "WBGene00004458", "O44156", "WBGene00003927", "Q22253", "WBGene00004465", "O76577", "WBGene00004467", "P90868", "WBGene00003953", "Q19324", "WBGene00004461", "Q17971", "WBGene00007588", "Q23237", "WBGene00003949", "Q20938", "WBGene00004462", "Q17361", "WBGene00006856" ] }, "reaction_10557670": { "compartment": "compartment_7660", "id": "reaction_10557670", "reactome": "R-CEL-5696605", "name": "USP12, USP26 deubiquitinate AR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10557665" ], "products": [ "species_10556462", "species_10557667" ], "modifiers": [ [ "species_10557665", "catalyst" ] ], "additional_components": [ "P34547", "WBGene00011216", "D9N129", "WBGene00007428", "Q20059", "WBGene00009441", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "P49632", "WBGene00006728", "P34547", "WBGene00011216", "D9N129", "WBGene00007428", "Q20059", "WBGene00009441", "P34547", "WBGene00011216", "D9N129", "WBGene00007428", "Q20059", "WBGene00009441" ] }, "reaction_10557721": { "compartment": "compartment_7660", "id": "reaction_10557721", "reactome": "R-CEL-5696958", "name": "USP44 deubiquitinates CDC20", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10557716" ], "products": [ "species_10556462", "species_10557718" ], "modifiers": [ [ "species_10557716", "catalyst" ] ], "additional_components": [ "Q9GRV2", "WBGene00013506", "Q09373", "WBGene00001511", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "P49632", "WBGene00006728", "Q9GRV2", "WBGene00013506", "Q09373", "WBGene00001511", "Q9GRV2", "WBGene00013506", "Q09373", "WBGene00001511" ] }, "reaction_10557836": { "compartment": "compartment_70101", "id": "reaction_10557836", "reactome": "R-CEL-6781797", "name": "USP19 binds HIF1A,BIRC2,BIRC3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10532174", "species_10557832" ], "products": [ "species_10557834" ], "modifiers": [], "additional_components": [ "WBGene00001851", "WBGene00008441", "G5EBW2", "WBGene00008441", "G5EGD2", "WBGene00001851" ] }, "reaction_10557788": { "compartment": "compartment_7660", "id": "reaction_10557788", "reactome": "R-CEL-5697009", "name": "USP37:RUVLB1:PSMC5 deubiquitinates CCNA1,CCNA2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10557781" ], "products": [ "species_10556462", "species_10557785" ], "modifiers": [ [ "species_10557781", "catalyst" ] ], "additional_components": [ "Q9XTT9", "WBGene00004506", "O17607", "WBGene00007784", "P34638", "WBGene00000863", "Q22319", "WBGene00011591", "Q9U2M5", "WBGene00000870", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "P49632", "WBGene00006728", "Q9XTT9", "WBGene00004506", "O17607", "WBGene00007784", "P34638", "WBGene00000863", "Q22319", "WBGene00011591", "Q9U2M5", "WBGene00000870", "Q9XTT9", "WBGene00004506", "O17607", "WBGene00007784", "P34638", "WBGene00000863", "Q22319", "WBGene00011591", "Q9U2M5", "WBGene00000870" ] }, "reaction_10557678": { "compartment": "compartment_70101", "id": "reaction_10557678", "reactome": "R-CEL-5696627", "name": "CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10557675" ], "products": [ "species_10511035", "species_10511040" ], "modifiers": [ [ "species_10557675", "catalyst" ] ], "additional_components": [ "Q7JMS4", "WBGene00009594", "Q9NAC7", "WBGene00013149", "P37165", "WBGene00006725", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "WBGene00013149", "Q7JMS4", "WBGene00009594", "Q9NAC7", "WBGene00013149" ] }, "reaction_10556096": { "compartment": "compartment_7660", "id": "reaction_10556096", "reactome": "R-CEL-5688834", "name": "ATXN3 binds VCP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10554396", "species_10556072" ], "products": [ "species_10556094" ], "modifiers": [], "additional_components": [ "P54812", "WBGene00008053", "WBGene00006446", "O17850", "WBGene00006446", "P54812", "WBGene00008053" ] }, "reaction_10556092": { "compartment": "compartment_70101", "id": "reaction_10556092", "reactome": "R-CEL-5688797", "name": "ATXN3 family cleave Ub chains", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10511035" ], "products": [ "species_10511035", "species_10511033" ], "modifiers": [ [ "species_10556089", "catalyst" ] ], "additional_components": [ "P37165", "WBGene00006725", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "Q8IAA2", "WBGene00022190", "O17850", "WBGene00006446" ] }, "reaction_10556076": { "compartment": "compartment_7660", "id": "reaction_10556076", "reactome": "R-CEL-5688786", "name": "ATXN3 binds RAD23", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10556072", "species_10556065" ], "products": [ "species_10556074" ], "modifiers": [], "additional_components": [ "WBGene00006446", "WBGene00013924", "Q23451", "WBGene00013924", "O17850", "WBGene00006446" ] }, "reaction_10520355": { "compartment": "compartment_7660", "id": "reaction_10520355", "reactome": "R-CEL-382096", "name": "Formation of NR-NCOR Corepressor Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10517933", "species_10519526" ], "products": [ "species_10520353" ], "modifiers": [], "additional_components": [ "WBGene00001565", "P41830", "WBGene00004786", "Q10902", "WBGene00003601", "Q20765", "WBGene00003606", "Q9XUK7", "WBGene00003675", "G5EDJ0", "WBGene00001400", "Q9XVV3", "WBGene00003657", "Q94407", "WBGene00003638", "Q9XYB7", "WBGene00003607", "G5EFF5", "WBGene00000908", "P41829", "WBGene00003605", "Q9U2R6", "WBGene00003681", "Q3V5L2", "WBGene00022423", "Q19345", "WBGene00003623", "G5ED17", "WBGene00010427", "G5ECR9", "WBGene00006790", "Q17771", "WBGene00003628", "Q9N2W3", "WBGene00022374", "Q18190", "WBGene00016126", "Q9XTJ4", "WBGene00003602", "Q21104", "WBGene00003629", "P41828", "WBGene00003622", "P41830", "WBGene00004786", "Q10902", "WBGene00003601", "Q20765", "WBGene00003606", "Q9XUK7", "WBGene00003675", "G5EDJ0", "WBGene00001400", "Q9XVV3", "WBGene00003657", "Q94407", "WBGene00003638", "Q9XYB7", "WBGene00003607", "G5EFF5", "WBGene00000908", "P41829", "WBGene00003605", "Q9U2R6", "WBGene00003681", "Q3V5L2", "WBGene00022423", "Q19345", "WBGene00003623", "G5ED17", "WBGene00010427", "G5ECR9", "WBGene00006790", "Q17771", "WBGene00003628", "Q9N2W3", "WBGene00022374", "Q18190", "WBGene00016126", "Q9XTJ4", "WBGene00003602", "Q21104", "WBGene00003629", "P41828", "WBGene00003622", "P34333", "WBGene00001565" ] }, "reaction_10564209": { "compartment": "compartment_70101", "id": "reaction_10564209", "reactome": "R-CEL-6814096", "name": "ARL1:GTP binds SCOC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10564205", "species_10564157" ], "products": [ "species_10564207" ], "modifiers": [], "additional_components": [ "WBGene00006802", "Q20758", "WBGene00000187", "species_29438", "Q20758", "WBGene00000187", "species_29438", "A7LPF8", "WBGene00006802" ] }, "reaction_10564165": { "compartment": "compartment_263163", "id": "reaction_10564165", "reactome": "R-CEL-6814086", "name": "ARFRP1 recruits ARL1 to the TGN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10564157", "species_10564149" ], "products": [ "species_10564163" ], "modifiers": [], "additional_components": [ "Q20758", "WBGene00000187", "species_29438", "Q9N3C8", "WBGene00021841", "species_29438", "Q8I7G0", "WBGene00020193", "species_29438", "Q20758", "WBGene00000187", "Q9N3C8", "WBGene00021841", "Q8I7G0", "WBGene00020193" ] }, "reaction_10564037": { "compartment": "compartment_263163", "id": "reaction_10564037", "reactome": "R-CEL-6811429", "name": "RIC1:RGP1 stimulates nucleotide RAB6 nucleotide exchange", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10564028" ], "products": [ "species_29420", "species_10564034" ], "modifiers": [ [ "species_10564028", "catalyst" ] ], "additional_components": [ "P34213", "WBGene00004269", "Q22782", "WBGene00004270", "species_29420", "Q7YWW8", "WBGene00010815", "Q09417", "WBGene00011071", "P34213", "WBGene00004269", "Q22782", "WBGene00004270", "species_29438", "Q7YWW8", "WBGene00010815", "Q09417", "WBGene00011071", "P34213", "WBGene00004269", "Q22782", "WBGene00004270", "species_29420", "Q7YWW8", "WBGene00010815", "Q09417", "WBGene00011071" ] }, "reaction_10564519": { "compartment": "compartment_263163", "id": "reaction_10564519", "reactome": "R-CEL-8847534", "name": "RAB43 hydrolyses GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10564512" ], "products": [ "species_10564516" ], "modifiers": [ [ "species_10564512", "catalyst" ] ], "additional_components": [ "Q9U2D8", "WBGene00012894", "Q9U1W9", "WBGene00004278", "species_29438", "species_29420", "Q9U1W9", "WBGene00004278", "Q9U2D8", "WBGene00012894", "Q9U2D8", "WBGene00012894", "Q9U1W9", "WBGene00004278", "species_29438" ] }, "reaction_10564422": { "compartment": "compartment_263163", "id": "reaction_10564422", "reactome": "R-CEL-6814676", "name": "SNAPs and NSF hexamer bind cis-SNARE at the TGN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10564418", "species_10557345", "species_10557329" ], "products": [ "species_10564420" ], "modifiers": [], "additional_components": [ "O02495", "WBGene00004897", "Q9TY08", "WBGene00022534", "O18230", "WBGene00013302", "Q18921", "WBGene00017016", "Q94392", "WBGene00003818", "Q94392", "WBGene00003818", "Q18921", "WBGene00017016", "O02495", "WBGene00004897", "Q9TY08", "WBGene00022534", "O18230", "WBGene00013302" ] }, "reaction_10564200": { "compartment": "compartment_70101", "id": "reaction_10564200", "reactome": "R-CEL-6814094", "name": "ARL1:GTP binds ARFIP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10564157", "species_10564196" ], "products": [ "species_10564198" ], "modifiers": [], "additional_components": [ "Q20758", "WBGene00000187", "species_29438", "WBGene00010040", "P34445", "WBGene00010040", "Q20758", "WBGene00000187", "species_29438" ] }, "reaction_10564171": { "compartment": "compartment_263163", "id": "reaction_10564171", "reactome": "R-CEL-6814088", "name": "SYS1 binds AcM-ARFRP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10564139", "species_10564169" ], "products": [ "species_10564149" ], "modifiers": [], "additional_components": [ "WBGene00020193", "Q9N3C8", "WBGene00021841", "species_29438", "Q9N3C8", "WBGene00021841", "species_29438", "Q8I7G0", "WBGene00020193" ] }, "reaction_10564523": { "compartment": "compartment_263163", "id": "reaction_10564523", "reactome": "R-CEL-8847537", "name": "RAB43:GTP binds USP8NL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10564510", "species_10564521" ], "products": [ "species_10564512" ], "modifiers": [], "additional_components": [ "Q9U1W9", "WBGene00004278", "species_29438", "WBGene00012894", "Q9U2D8", "WBGene00012894", "Q9U1W9", "WBGene00004278", "species_29438" ] }, "reaction_10564191": { "compartment": "compartment_263163", "id": "reaction_10564191", "reactome": "R-CEL-6814091", "name": "ARL1 recruits TGN Golgin homodimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10564187", "species_10564163" ], "products": [ "species_10564189" ], "modifiers": [], "additional_components": [ "A0A3P6PCP8", "WBGene00010306", "Q18013", "WBGene00002220", "species_29438", "Q20758", "WBGene00000187", "Q9N3C8", "WBGene00021841", "Q8I7G0", "WBGene00020193", "species_29438", "Q20758", "WBGene00000187", "Q9N3C8", "WBGene00021841", "Q8I7G0", "WBGene00020193", "A0A3P6PCP8", "WBGene00010306", "Q18013", "WBGene00002220" ] }, "reaction_10564030": { "compartment": "compartment_263163", "id": "reaction_10564030", "reactome": "R-CEL-6811428", "name": "RIC1:RGP1 recruits RAB6:GDP to the TGN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10563998", "species_10564010" ], "products": [ "species_10564028" ], "modifiers": [], "additional_components": [ "species_29420", "P34213", "WBGene00004269", "Q22782", "WBGene00004270", "Q7YWW8", "WBGene00010815", "Q09417", "WBGene00011071", "P34213", "WBGene00004269", "Q22782", "WBGene00004270", "species_29420", "Q7YWW8", "WBGene00010815", "Q09417", "WBGene00011071" ] }, "reaction_10546544": { "compartment": "compartment_7660", "id": "reaction_10546544", "reactome": "R-CEL-3209159", "name": "Phosphorylated ERF translocates to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546532" ], "products": [ "species_10546542" ], "modifiers": [], "additional_components": [ "A0A4V0IJZ6", "WBGene00304788", "O44138", "WBGene00016798", "A0A4V0IK77", "WBGene00016865", "G5EDL0", "WBGene00002990", "A0A4V0IJZ6", "WBGene00304788", "A0A4V0IK77", "WBGene00016865", "G5EDL0", "WBGene00002990", "O44138", "WBGene00016798" ] }, "reaction_10508244": { "compartment": "compartment_5460", "id": "reaction_10508244", "reactome": "R-CEL-77321", "name": "3-Oxohexanoyl-CoA+CoA-SH<=>Butanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_77320" ], "products": [ "species_77318", "species_113559" ], "modifiers": [ [ "species_10508211", "catalyst" ] ], "additional_components": [ "P34255", "WBGene00015125", "Q9GYT0", "WBGene00020347" ] }, "reaction_10508246": { "compartment": "compartment_5460", "id": "reaction_10508246", "reactome": "R-CEL-77323", "name": "(S)-Hydroxyhexanoyl-CoA+NAD<=>3-Oxohexanoyl-CoA+NADH+H", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77322", "species_113526" ], "products": [ "species_77320", "species_113529", "species_29362" ], "modifiers": [ [ "species_10508194", "catalyst" ] ], "additional_components": [ "P41938", "WBGene00007129" ] }, "reaction_10508248": { "compartment": "compartment_5460", "id": "reaction_10508248", "reactome": "R-CEL-77325", "name": "trans-Hex-2-enoyl-CoA+H2O<=>(S)-Hydroxyhexanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77324", "species_113521" ], "products": [ "species_77322" ], "modifiers": [ [ "species_10503463", "catalyst" ] ], "additional_components": [ "P34559", "WBGene00001155" ] }, "reaction_10557962": { "compartment": "compartment_7660", "id": "reaction_10557962", "reactome": "R-CEL-6782227", "name": "Ligation of newly synthesized repair patch to incised DNA in TC-NER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10557947" ], "products": [ "species_10557960", "species_10556705" ], "modifiers": [ [ "species_10502732", "catalyst" ] ], "additional_components": [ "Q95Y97", "WBGene00019767", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "P90829", "WBGene00008645", "Q19366", "WBGene00008722", "Q21730", "WBGene00011016", "O02115", "WBGene00003955", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "P34409", "WBGene00017696", "Q19826", "WBGene00017830", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "O02092", "WBGene00018391", "Q9GR61", "WBGene00021347", "Q9N3C9", "WBGene00021845", "Q93338", "WBGene00007971", "Q18963", "WBGene00008403", "Q21554", "WBGene00010890", "Q23457", "WBGene00004320", "Q17392", "WBGene00000839", "P34545", "WBGene00000366", "Q23088", "WBGene00022812", "Q7JKC3", "WBGene00010406", "H2KYV0", "WBGene00016115", "P52652", "WBGene00012000", "Q86D18", "WBGene00010011", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q10051", "WBGene00020423", "Q20716", "WBGene00009966", "Q9U1Q7", "WBGene00001258", "Q9U2S6", "WBGene00000889", "P52009", "WBGene00000877", "P52016", "WBGene00000884", "P91175", "WBGene00016837", "Q22139", "WBGene00011411", "Q19826", "WBGene00017830", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "O02092", "WBGene00018391", "Q9GR61", "WBGene00021347", "Q9N3C9", "WBGene00021845", "Q93338", "WBGene00007971", "Q18963", "WBGene00008403", "Q21554", "WBGene00010890", "Q23457", "WBGene00004320", "Q17392", "WBGene00000839", "P34545", "WBGene00000366", "Q23088", "WBGene00022812", "Q7JKC3", "WBGene00010406", "H2KYV0", "WBGene00016115", "P52652", "WBGene00012000", "Q86D18", "WBGene00010011", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q10051", "WBGene00020423", "Q20716", "WBGene00009966", "Q9U1Q7", "WBGene00001258", "Q9U2S6", "WBGene00000889", "P52009", "WBGene00000877", "P52016", "WBGene00000884", "P91175", "WBGene00016837", "Q22139", "WBGene00011411", "Q95Y97", "WBGene00019767", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "P90829", "WBGene00008645", "Q19366", "WBGene00008722", "Q21730", "WBGene00011016", "O02115", "WBGene00003955", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "P34409", "WBGene00017696", "WBGene00002985" ] }, "reaction_10557950": { "compartment": "compartment_7660", "id": "reaction_10557950", "reactome": "R-CEL-6782208", "name": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30555", "species_10557945" ], "products": [ "species_10557947", "species_113541" ], "modifiers": [ [ "species_10557945", "catalyst" ] ], "additional_components": [ "Q95Y97", "WBGene00019767", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "P90829", "WBGene00008645", "Q19366", "WBGene00008722", "Q21730", "WBGene00011016", "O02115", "WBGene00003955", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "P34409", "WBGene00017696", "Q19826", "WBGene00017830", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "O02092", "WBGene00018391", "Q9GR61", "WBGene00021347", "Q9N3C9", "WBGene00021845", "Q93338", "WBGene00007971", "Q18963", "WBGene00008403", "Q21554", "WBGene00010890", "Q23457", "WBGene00004320", "Q17392", "WBGene00000839", "P34545", "WBGene00000366", "Q23088", "WBGene00022812", "Q7JKC3", "WBGene00010406", "H2KYV0", "WBGene00016115", "P52652", "WBGene00012000", "Q86D18", "WBGene00010011", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q10051", "WBGene00020423", "Q20716", "WBGene00009966", "Q9U1Q7", "WBGene00001258", "Q9U2S6", "WBGene00000889", "P52009", "WBGene00000877", "P52016", "WBGene00000884", "P91175", "WBGene00016837", "Q22139", "WBGene00011411", "Q95Y97", "WBGene00019767", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "P90829", "WBGene00008645", "Q19366", "WBGene00008722", "Q21730", "WBGene00011016", "O02115", "WBGene00003955", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "P34409", "WBGene00017696", "Q19826", "WBGene00017830", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "O02092", "WBGene00018391", "Q9GR61", "WBGene00021347", "Q9N3C9", "WBGene00021845", "Q93338", "WBGene00007971", "Q18963", "WBGene00008403", "Q21554", "WBGene00010890", "Q23457", "WBGene00004320", "Q17392", "WBGene00000839", "P34545", "WBGene00000366", "Q23088", "WBGene00022812", "Q7JKC3", "WBGene00010406", "H2KYV0", "WBGene00016115", "P52652", "WBGene00012000", "Q86D18", "WBGene00010011", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q10051", "WBGene00020423", "Q20716", "WBGene00009966", "Q9U1Q7", "WBGene00001258", "Q9U2S6", "WBGene00000889", "P52009", "WBGene00000877", "P52016", "WBGene00000884", "P91175", "WBGene00016837", "Q22139", "WBGene00011411", "Q95Y97", "WBGene00019767", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "P90829", "WBGene00008645", "Q19366", "WBGene00008722", "Q21730", "WBGene00011016", "O02115", "WBGene00003955", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "P34409", "WBGene00017696", "Q19826", "WBGene00017830", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "O02092", "WBGene00018391", "Q9GR61", "WBGene00021347", "Q9N3C9", "WBGene00021845", "Q93338", "WBGene00007971", "Q18963", "WBGene00008403", "Q21554", "WBGene00010890", "Q23457", "WBGene00004320", "Q17392", "WBGene00000839", "P34545", "WBGene00000366", "Q23088", "WBGene00022812", "Q7JKC3", "WBGene00010406", "H2KYV0", "WBGene00016115", "P52652", "WBGene00012000", "Q86D18", "WBGene00010011", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q10051", "WBGene00020423", "Q20716", "WBGene00009966", "Q9U1Q7", "WBGene00001258", "Q9U2S6", "WBGene00000889", "P52009", "WBGene00000877", "P52016", "WBGene00000884", "P91175", "WBGene00016837", "Q22139", "WBGene00011411" ] }, "reaction_10517125": { "compartment": "compartment_7660", "id": "reaction_10517125", "reactome": "R-CEL-212269", "name": "DNMT1,3A,3B:PRC2 methylates cytosine and histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10517106" ], "products": [ "species_77502", "species_10517122" ], "modifiers": [ [ "species_10517106", "catalyst" ] ], "additional_components": [ "P62784", "WBGene00001875", "K7ZUH9", "WBGene00001914", "Q10453", "WBGene00001945", "Q9GYS1", "WBGene00003224", "O17514", "WBGene00003220", "P90916", "WBGene00003036", "P90917", "WBGene00004312", "Q9GYS1", "WBGene00003224", "O17514", "WBGene00003220", "P90916", "WBGene00003036", "P90917", "WBGene00004312", "P62784", "WBGene00001875", "Q10453", "WBGene00001945", "K7ZUH9", "WBGene00001914", "P62784", "WBGene00001875", "K7ZUH9", "WBGene00001914", "Q10453", "WBGene00001945", "Q9GYS1", "WBGene00003224", "O17514", "WBGene00003220", "P90916", "WBGene00003036", "P90917", "WBGene00004312" ] }, "reaction_10568425": { "compartment": "compartment_7660", "id": "reaction_10568425", "reactome": "R-CEL-8938853", "name": "CDK6 binds RUNX1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10568421", "species_10568419" ], "products": [ "species_10568423" ], "modifiers": [], "additional_components": [ "G5EFQ5", "WBGene00004393", "Q95ZL9", "WBGene00000272", "WBGene00000406", "Q9XTR1", "WBGene00000406", "G5EFQ5", "WBGene00004393", "Q95ZL9", "WBGene00000272" ] }, "reaction_10566203": { "compartment": "compartment_7660", "id": "reaction_10566203", "reactome": "R-CEL-8865320", "name": "CBFB binds RUNX1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10566199", "species_10566197" ], "products": [ "species_10566201" ], "modifiers": [], "additional_components": [ "WBGene00004393", "WBGene00000272", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393" ] }, "reaction_10568429": { "compartment": "compartment_7660", "id": "reaction_10568429", "reactome": "R-CEL-8938887", "name": "PML binds RUNX1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546215", "species_10566199" ], "products": [ "species_10568427" ], "modifiers": [], "additional_components": [ "WBGene00006523", "WBGene00004393", "G5EFQ5", "WBGene00004393", "G5ED20", "WBGene00006523" ] }, "reaction_10567459": { "compartment": "compartment_70101", "id": "reaction_10567459", "reactome": "R-CEL-8876312", "name": "SLC5A12 cotransports Na+ with LACT, PYR, NCA from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8876310", "species_74113" ], "products": [ "species_83910", "species_8876304" ], "modifiers": [ [ "species_10567456", "catalyst" ] ], "additional_components": [ "species_113557", "species_29708", "species_8869604", "species_113557", "species_29708", "species_197230", "WBGene00018716" ] }, "reaction_10553973": { "compartment": "compartment_70101", "id": "reaction_10553973", "reactome": "R-CEL-5627802", "name": "SLC26A4 transports I- from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_209785" ], "products": [ "species_209818" ], "modifiers": [ [ "species_10553970", "catalyst" ] ], "additional_components": [ "Q94225", "WBGene00018283", "G5EC30", "WBGene00012259", "G5EEA7", "WBGene00010788", "G5EED0", "WBGene00016945", "G5EFB2", "WBGene00013963", "O17951", "WBGene00010789", "O45016", "WBGene00020914" ] }, "reaction_10522983": { "compartment": "compartment_876", "id": "reaction_10522983", "reactome": "R-CEL-427666", "name": "SLC26A3,6 exchange Cl- for HCO3-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_188972", "species_111627" ], "products": [ "species_425425", "species_352022" ], "modifiers": [ [ "species_10522980", "catalyst" ] ], "additional_components": [ "Q94225", "WBGene00018283", "G5EC30", "WBGene00012259", "G5EEA7", "WBGene00010788", "G5EED0", "WBGene00016945", "G5EFB2", "WBGene00013963", "O17951", "WBGene00010789", "O45016", "WBGene00020914" ] }, "reaction_10522894": { "compartment": "compartment_876", "id": "reaction_10522894", "reactome": "R-CEL-427570", "name": "Group 3 - Selective Cl- transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_188972" ], "products": [ "species_352022" ], "modifiers": [ [ "species_10522891", "catalyst" ] ], "additional_components": [ "G5EDS5", "WBGene00017464", "G5EFB2", "WBGene00013963", "O17951", "WBGene00010789", "O45016", "WBGene00020914", "Q94225", "WBGene00018283", "G5EC30", "WBGene00012259", "G5EEA7", "WBGene00010788", "G5EED0", "WBGene00016945" ] }, "reaction_10521777": { "compartment": "compartment_876", "id": "reaction_10521777", "reactome": "R-CEL-418309", "name": "ATP2B1-4 transport cytosolic Ca2+ to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74016" ], "products": [ "species_74112" ], "modifiers": [ [ "species_10521774", "catalyst" ] ], "additional_components": [ "Q95XP5", "WBGene00003153", "Q9TYP9", "WBGene00019875", "G5EFR6", "WBGene00003151" ] }, "reaction_10522476": { "compartment": "compartment_876", "id": "reaction_10522476", "reactome": "R-CEL-425661", "name": "SLC8A1,2,3 exchange 3Na+ for Ca2+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74016", "species_74113" ], "products": [ "species_83910", "species_74112" ], "modifiers": [ [ "species_10522473", "catalyst" ], [ "species_10504094", "inhibitor" ] ], "additional_components": [ "G5EF08", "WBGene00003566", "H2KYP2", "WBGene00003567", "Q11083", "WBGene00020378", "P04630", "WBGene00000285", "G5EF37", "WBGene00003934", "A0A2C9C3L3", "WBGene00020378", "Q18136", "WBGene00006861", "Q09665", "WBGene00006583", "O02159", "WBGene00020378", "G5EDZ8", "WBGene00000288", "Q94288", "WBGene00000287", "Q09980", "WBGene00017394", "O16305", "WBGene00000552", "G5EEG0", "WBGene00000286" ] }, "reaction_10521789": { "compartment": "compartment_114521", "id": "reaction_10521789", "reactome": "R-CEL-418365", "name": "ATP2A1-3 transport cytosolic Ca2+ to dense tubular network lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_427899", "species_74016" ], "products": [ "species_70106", "species_139827" ], "modifiers": [ [ "species_10521782", "catalyst" ] ], "additional_components": [ "WBGene00004736" ] }, "reaction_10521026": { "compartment": "compartment_70101", "id": "reaction_10521026", "reactome": "R-CEL-392195", "name": "Gi activation by P2Y purinoceptor 12", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10521021" ], "products": [ "species_10521023", "species_29420" ], "modifiers": [ [ "species_10521021", "catalyst" ] ], "additional_components": [ "species_29420", "O76584", "WBGene00001673", "Q9BIG5", "WBGene00001666", "Q21917", "WBGene00001669", "P91907", "WBGene00001677", "Q93743", "WBGene00001668", "Q20907", "WBGene00001670", "Q9BIG2", "WBGene00001676", "Q20910", "WBGene00001671", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "species_113582", "species_113582", "species_29438", "O76584", "WBGene00001673", "Q9BIG5", "WBGene00001666", "Q21917", "WBGene00001669", "P91907", "WBGene00001677", "Q93743", "WBGene00001668", "Q20907", "WBGene00001670", "Q9BIG2", "WBGene00001676", "Q20910", "WBGene00001671", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "species_29420", "O76584", "WBGene00001673", "Q9BIG5", "WBGene00001666", "Q21917", "WBGene00001669", "P91907", "WBGene00001677", "Q93743", "WBGene00001668", "Q20907", "WBGene00001670", "Q9BIG2", "WBGene00001676", "Q20910", "WBGene00001671", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "species_113582" ] }, "reaction_10516882": { "compartment": "compartment_7660", "id": "reaction_10516882", "reactome": "R-CEL-211178", "name": "Phosphorylated FOXO1A is excluded from the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10514285" ], "products": [ "species_10516880" ], "modifiers": [], "additional_components": [ "WBGene00000912", "WBGene00000912" ] }, "reaction_10516878": { "compartment": "compartment_7660", "id": "reaction_10516878", "reactome": "R-CEL-211164", "name": "AKT phosphorylates FOXO1A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10514274" ], "products": [ "species_113582", "species_10514285" ], "modifiers": [ [ "species_10514266", "catalyst" ] ], "additional_components": [ "WBGene00000912", "WBGene00000912", "G4S4W1", "WBGene00016980", "Q17941", "WBGene00000102", "Q9XTG7", "WBGene00000103" ] }, "reaction_10544176": { "compartment": "compartment_70101", "id": "reaction_10544176", "reactome": "R-CEL-2408524", "name": "Sec is reduced to H2Se by PXLP-K259-SCLY dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5359016", "species_5357697" ], "products": [ "species_5357660", "species_29432", "species_5359011" ], "modifiers": [ [ "species_10544173", "catalyst" ] ], "additional_components": [ "Q19434", "WBGene00017442" ] }, "reaction_10557618": { "compartment": "compartment_5460", "id": "reaction_10557618", "reactome": "R-CEL-5696415", "name": "PXLP-K278-ETNPPL tetramer hydrolyses PETA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5696414", "species_113521" ], "products": [ "species_113548", "species_113532", "species_5693978" ], "modifiers": [ [ "species_10557615", "catalyst" ] ], "additional_components": [ "P91408", "WBGene00020139" ] }, "reaction_10535129": { "compartment": "compartment_12045", "id": "reaction_10535129", "reactome": "R-CEL-1483203", "name": "PA is dephosphorylated to DAG by LPIN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_426755" ], "products": [ "species_29372", "species_1500596" ], "modifiers": [ [ "species_10535126", "catalyst" ] ], "additional_components": [ "species_114632", "Q9XXT5", "WBGene00010425" ] }, "reaction_10535146": { "compartment": "compartment_70101", "id": "reaction_10535146", "reactome": "R-CEL-1483222", "name": "ETA is phosphorylated to PETA by CHK/ETNK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1498751" ], "products": [ "species_29370", "species_428686" ], "modifiers": [ [ "species_10535028", "catalyst" ] ], "additional_components": [ "P46560", "WBGene00000513", "O17610", "WBGene00000509", "Q22820", "WBGene00000515", "P46558", "WBGene00000511", "Q22942", "WBGene00000510", "P46559", "WBGene00000512", "Q9GZF3", "WBGene00000514" ] }, "reaction_10535118": { "compartment": "compartment_12045", "id": "reaction_10535118", "reactome": "R-CEL-1483190", "name": "PETA and CTP are condensed to CDP-ETA by PCY2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428686", "species_110614" ], "products": [ "species_111294", "species_1500603" ], "modifiers": [ [ "species_10535115", "catalyst" ] ], "additional_components": [ "X5LPX5", "WBGene00021352" ] }, "reaction_10534959": { "compartment": "compartment_12045", "id": "reaction_10534959", "reactome": "R-CEL-1482962", "name": "CDP-ETA and DAG are converted to PE by CEPT1/EPT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500603", "species_1500596" ], "products": [ "species_1500581", "species_109395" ], "modifiers": [ [ "species_10534956", "catalyst" ] ], "additional_components": [ "species_114632", "species_266099", "G5EC09", "WBGene00009057", "G5EC25", "WBGene00013024", "O44732", "WBGene00018797" ] }, "reaction_10557283": { "compartment": "compartment_12045", "id": "reaction_10557283", "reactome": "R-CEL-5694413", "name": "SEC4C,D bind GOSR2 and STX5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10515692", "species_10515690", "species_10515696" ], "products": [ "species_10515698" ], "modifiers": [], "additional_components": [ "WBGene00004755", "P41941", "WBGene00007128", "Q20797", "WBGene00006373", "WBGene00004754", "Q9U2Z1", "WBGene00004754", "P41941", "WBGene00007128", "Q20797", "WBGene00006373", "Q19371", "WBGene00004755" ] }, "reaction_10557378": { "compartment": "compartment_12045", "id": "reaction_10557378", "reactome": "R-CEL-5694428", "name": "LMAN family proteins bind glycosylated cargo", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10515814", "species_10515745" ], "products": [ "species_10515816" ], "modifiers": [], "additional_components": [ "A9Z1L1", "WBGene00005648", "Q19651", "WBGene00005649", "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q21810", "WBGene00011102", "P92005", "WBGene00000789", "Q9XWA4", "WBGene00013764", "Q18740", "WBGene00008231", "Q9XXQ7", "WBGene00013764", "G5EGP8", "WBGene00000788", "Q9U2X1", "WBGene00013764", "G5EDE8", "WBGene00002070", "G5EDE8", "WBGene00002070", "A9Z1L1", "WBGene00005648", "Q19651", "WBGene00005649", "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q21810", "WBGene00011102", "P92005", "WBGene00000789", "Q9XWA4", "WBGene00013764", "Q18740", "WBGene00008231", "Q9XXQ7", "WBGene00013764", "G5EGP8", "WBGene00000788", "Q9U2X1", "WBGene00013764" ] }, "reaction_10557287": { "compartment": "compartment_12045", "id": "reaction_10557287", "reactome": "R-CEL-5694415", "name": "SEC24A,B:SEC23A bind SEC22B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10515950", "species_10515624", "species_10515696" ], "products": [ "species_10557285" ], "modifiers": [], "additional_components": [ "WBGene00004756", "WBGene00018853", "WBGene00004754", "Q9U2Z1", "WBGene00004754", "Q94241", "WBGene00018853", "Q23368", "WBGene00004756" ] }, "reaction_10557501": { "compartment": "compartment_12045", "id": "reaction_10557501", "reactome": "R-CEL-5694522", "name": "Inner coat assembly and cargo binding", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10515678", "species_10515818", "species_10515956" ], "products": [ "species_10515820" ], "modifiers": [], "additional_components": [ "Q23445", "WBGene00022678", "species_29438", "Q9U2Z1", "WBGene00004754", "P41941", "WBGene00007128", "Q20797", "WBGene00006373", "Q19371", "WBGene00004755", "G5EDE8", "WBGene00002070", "A9Z1L1", "WBGene00005648", "Q19651", "WBGene00005649", "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q21810", "WBGene00011102", "P92005", "WBGene00000789", "Q9XWA4", "WBGene00013764", "Q18740", "WBGene00008231", "Q9XXQ7", "WBGene00013764", "G5EGP8", "WBGene00000788", "Q9U2X1", "WBGene00013764", "Q22361", "WBGene00011648", "Q10914", "WBGene00001613", "Q21415", "WBGene00001614", "Q8MXV8", "WBGene00001617", "P34299", "WBGene00001612", "Q9U2Z1", "WBGene00004754", "Q19371", "WBGene00004755", "Q23368", "WBGene00004756", "Q23368", "WBGene00004756", "Q19371", "WBGene00004755", "Q9U2Z1", "WBGene00004754", "P41941", "WBGene00007128", "Q20797", "WBGene00006373", "G5EDE8", "WBGene00002070", "A9Z1L1", "WBGene00005648", "Q19651", "WBGene00005649", "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q21810", "WBGene00011102", "P92005", "WBGene00000789", "Q9XWA4", "WBGene00013764", "Q18740", "WBGene00008231", "Q9XXQ7", "WBGene00013764", "G5EGP8", "WBGene00000788", "Q9U2X1", "WBGene00013764", "Q22361", "WBGene00011648", "Q10914", "WBGene00001613", "Q21415", "WBGene00001614", "Q8MXV8", "WBGene00001617", "P34299", "WBGene00001612", "Q23445", "WBGene00022678", "species_29438" ] }, "reaction_10557388": { "compartment": "compartment_12045", "id": "reaction_10557388", "reactome": "R-CEL-5694442", "name": "CNIH2,3 bind GRIA1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10515725", "species_10515703" ], "products": [ "species_10515727" ], "modifiers": [], "additional_components": [ "Q10914", "WBGene00001613", "Q21415", "WBGene00001614", "Q8MXV8", "WBGene00001617", "P34299", "WBGene00001612", "WBGene00011648", "Q22361", "WBGene00011648", "Q10914", "WBGene00001613", "Q21415", "WBGene00001614", "Q8MXV8", "WBGene00001617", "P34299", "WBGene00001612" ] }, "reaction_10557504": { "compartment": "compartment_70101", "id": "reaction_10557504", "reactome": "R-CEL-5694527", "name": "Loss of SAR1B GTPase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10515820" ], "products": [ "species_29372", "species_10515818", "species_10515956", "species_10515940" ], "modifiers": [ [ "species_10515820", "catalyst" ] ], "additional_components": [ "Q23368", "WBGene00004756", "Q19371", "WBGene00004755", "Q9U2Z1", "WBGene00004754", "P41941", "WBGene00007128", "Q20797", "WBGene00006373", "G5EDE8", "WBGene00002070", "A9Z1L1", "WBGene00005648", "Q19651", "WBGene00005649", "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q21810", "WBGene00011102", "P92005", "WBGene00000789", "Q9XWA4", "WBGene00013764", "Q18740", "WBGene00008231", "Q9XXQ7", "WBGene00013764", "G5EGP8", "WBGene00000788", "Q9U2X1", "WBGene00013764", "Q22361", "WBGene00011648", "Q10914", "WBGene00001613", "Q21415", "WBGene00001614", "Q8MXV8", "WBGene00001617", "P34299", "WBGene00001612", "Q23445", "WBGene00022678", "species_29438", "Q9U2Z1", "WBGene00004754", "P41941", "WBGene00007128", "Q20797", "WBGene00006373", "Q19371", "WBGene00004755", "G5EDE8", "WBGene00002070", "A9Z1L1", "WBGene00005648", "Q19651", "WBGene00005649", "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q21810", "WBGene00011102", "P92005", "WBGene00000789", "Q9XWA4", "WBGene00013764", "Q18740", "WBGene00008231", "Q9XXQ7", "WBGene00013764", "G5EGP8", "WBGene00000788", "Q9U2X1", "WBGene00013764", "Q22361", "WBGene00011648", "Q10914", "WBGene00001613", "Q21415", "WBGene00001614", "Q8MXV8", "WBGene00001617", "P34299", "WBGene00001612", "Q9U2Z1", "WBGene00004754", "Q19371", "WBGene00004755", "Q23368", "WBGene00004756", "species_29420", "Q23445", "WBGene00022678", "Q23368", "WBGene00004756", "Q19371", "WBGene00004755", "Q9U2Z1", "WBGene00004754", "P41941", "WBGene00007128", "Q20797", "WBGene00006373", "G5EDE8", "WBGene00002070", "A9Z1L1", "WBGene00005648", "Q19651", "WBGene00005649", "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q21810", "WBGene00011102", "P92005", "WBGene00000789", "Q9XWA4", "WBGene00013764", "Q18740", "WBGene00008231", "Q9XXQ7", "WBGene00013764", "G5EGP8", "WBGene00000788", "Q9U2X1", "WBGene00013764", "Q22361", "WBGene00011648", "Q10914", "WBGene00001613", "Q21415", "WBGene00001614", "Q8MXV8", "WBGene00001617", "P34299", "WBGene00001612", "Q23445", "WBGene00022678", "species_29438" ] }, "reaction_10557376": { "compartment": "compartment_6791047", "id": "reaction_10557376", "reactome": "R-CEL-5694425", "name": "NSF ATPase activity dissociates cis-SNARE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10557371", "species_113592" ], "products": [ "species_10557359", "species_10557357", "species_29372", "species_10557352", "species_10557350", "species_10557367", "species_10557329", "species_10557345" ], "modifiers": [ [ "species_10557371", "catalyst" ] ], "additional_components": [ "Q94392", "WBGene00003818", "Q18921", "WBGene00017016", "G5EEU1", "WBGene00043064", "P41941", "WBGene00007128", "Q20364", "WBGene00009654", "Q20797", "WBGene00006373", "Q94241", "WBGene00018853", "WBGene00006373", "WBGene00009654", "WBGene00007128", "WBGene00043064", "Q94241", "WBGene00018853", "Q94392", "WBGene00003818", "Q18921", "WBGene00017016", "Q94392", "WBGene00003818", "Q18921", "WBGene00017016", "G5EEU1", "WBGene00043064", "P41941", "WBGene00007128", "Q20364", "WBGene00009654", "Q20797", "WBGene00006373", "Q94241", "WBGene00018853" ] }, "reaction_10515938": { "compartment": "compartment_13959", "id": "reaction_10515938", "reactome": "R-CEL-203973", "name": "Vesicle budding", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10515831" ], "products": [ "species_10515935", "species_10515933", "species_29372", "species_10515827", "species_10515648" ], "modifiers": [ [ "species_10515831", "catalyst" ] ], "additional_components": [ "Q94241", "WBGene00018853", "G5EFY6", "WBGene00011338", "Q9N4A7", "WBGene00003806", "H2KZQ8", "WBGene00017419", "P34643", "WBGene00013985", "Q9U1W1", "WBGene00006565", "Q23368", "WBGene00004756", "Q19371", "WBGene00004755", "Q9U2Z1", "WBGene00004754", "P41941", "WBGene00007128", "Q20797", "WBGene00006373", "G5EDE8", "WBGene00002070", "A9Z1L1", "WBGene00005648", "Q19651", "WBGene00005649", "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q21810", "WBGene00011102", "P92005", "WBGene00000789", "Q9XWA4", "WBGene00013764", "Q18740", "WBGene00008231", "Q9XXQ7", "WBGene00013764", "G5EGP8", "WBGene00000788", "Q9U2X1", "WBGene00013764", "Q22361", "WBGene00011648", "Q10914", "WBGene00001613", "Q21415", "WBGene00001614", "Q8MXV8", "WBGene00001617", "P34299", "WBGene00001612", "Q23445", "WBGene00022678", "species_29438", "WBGene00022678", "Q94241", "WBGene00018853", "Q23368", "WBGene00004756", "Q19371", "WBGene00004755", "Q9U2Z1", "WBGene00004754", "Q10914", "WBGene00001613", "Q21415", "WBGene00001614", "Q8MXV8", "WBGene00001617", "P34299", "WBGene00001612", "Q22361", "WBGene00011648", "P41941", "WBGene00007128", "Q20797", "WBGene00006373", "G5EDE8", "WBGene00002070", "Q9U2X1", "WBGene00013764", "Q9XWA4", "WBGene00013764", "Q9XXQ7", "WBGene00013764", "G5EGP8", "WBGene00000788", "P92005", "WBGene00000789", "Q18740", "WBGene00008231", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "A9Z1L1", "WBGene00005648", "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "Q21810", "WBGene00011102", "G5EFY6", "WBGene00011338", "Q9N4A7", "WBGene00003806", "Q9U1W1", "WBGene00006565", "H2KZQ8", "WBGene00017419", "P34643", "WBGene00013985", "Q94241", "WBGene00018853", "G5EFY6", "WBGene00011338", "Q9N4A7", "WBGene00003806", "H2KZQ8", "WBGene00017419", "P34643", "WBGene00013985", "Q9U1W1", "WBGene00006565", "Q23368", "WBGene00004756", "Q19371", "WBGene00004755", "Q9U2Z1", "WBGene00004754", "P41941", "WBGene00007128", "Q20797", "WBGene00006373", "G5EDE8", "WBGene00002070", "A9Z1L1", "WBGene00005648", "Q19651", "WBGene00005649", "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q21810", "WBGene00011102", "P92005", "WBGene00000789", "Q9XWA4", "WBGene00013764", "Q18740", "WBGene00008231", "Q9XXQ7", "WBGene00013764", "G5EGP8", "WBGene00000788", "Q9U2X1", "WBGene00013764", "Q22361", "WBGene00011648", "Q10914", "WBGene00001613", "Q21415", "WBGene00001614", "Q8MXV8", "WBGene00001617", "P34299", "WBGene00001612", "Q23445", "WBGene00022678", "species_29438" ] }, "reaction_10557380": { "compartment": "compartment_13959", "id": "reaction_10557380", "reactome": "R-CEL-5694439", "name": "COPII coat binds TRAPPCII and RAB1:GDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10557214", "species_10557263", "species_10515933" ], "products": [ "species_10557265" ], "modifiers": [], "additional_components": [ "Q9UAQ6", "WBGene00004266", "species_29420", "Q9NA81", "WBGene00013259", "B1GRL5", "WBGene00077643", "G4SNB8", "WBGene00044604", "P34605", "WBGene00014222", "Q93330", "WBGene00007956", "B1V899", "WBGene00022138", "Q9XU81", "WBGene00010699", "O02173", "WBGene00021046", "Q20100", "WBGene00018088", "Q94241", "WBGene00018853", "Q23368", "WBGene00004756", "Q19371", "WBGene00004755", "Q9U2Z1", "WBGene00004754", "Q10914", "WBGene00001613", "Q21415", "WBGene00001614", "Q8MXV8", "WBGene00001617", "P34299", "WBGene00001612", "Q22361", "WBGene00011648", "P41941", "WBGene00007128", "Q20797", "WBGene00006373", "G5EDE8", "WBGene00002070", "Q9U2X1", "WBGene00013764", "Q9XWA4", "WBGene00013764", "Q9XXQ7", "WBGene00013764", "G5EGP8", "WBGene00000788", "P92005", "WBGene00000789", "Q18740", "WBGene00008231", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "A9Z1L1", "WBGene00005648", "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "Q21810", "WBGene00011102", "G5EFY6", "WBGene00011338", "Q9N4A7", "WBGene00003806", "Q94241", "WBGene00018853", "Q23368", "WBGene00004756", "Q19371", "WBGene00004755", "Q9U2Z1", "WBGene00004754", "Q10914", "WBGene00001613", "Q21415", "WBGene00001614", "Q8MXV8", "WBGene00001617", "P34299", "WBGene00001612", "Q22361", "WBGene00011648", "P41941", "WBGene00007128", "Q20797", "WBGene00006373", "G5EDE8", "WBGene00002070", "Q9U2X1", "WBGene00013764", "Q9XWA4", "WBGene00013764", "Q9XXQ7", "WBGene00013764", "G5EGP8", "WBGene00000788", "P92005", "WBGene00000789", "Q18740", "WBGene00008231", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "A9Z1L1", "WBGene00005648", "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "Q21810", "WBGene00011102", "G5EFY6", "WBGene00011338", "Q9N4A7", "WBGene00003806", "Q9NA81", "WBGene00013259", "B1GRL5", "WBGene00077643", "G4SNB8", "WBGene00044604", "P34605", "WBGene00014222", "Q93330", "WBGene00007956", "B1V899", "WBGene00022138", "Q9XU81", "WBGene00010699", "O02173", "WBGene00021046", "Q20100", "WBGene00018088", "Q9UAQ6", "WBGene00004266", "species_29420" ] }, "reaction_10557289": { "compartment": "compartment_12045", "id": "reaction_10557289", "reactome": "R-CEL-5694417", "name": "SEC16 complex binds SAR1B:GTP:SEC23:SEC24", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10515820", "species_10515827", "species_10515648" ], "products": [ "species_10515829" ], "modifiers": [], "additional_components": [ "Q23368", "WBGene00004756", "Q19371", "WBGene00004755", "Q9U2Z1", "WBGene00004754", "P41941", "WBGene00007128", "Q20797", "WBGene00006373", "G5EDE8", "WBGene00002070", "A9Z1L1", "WBGene00005648", "Q19651", "WBGene00005649", "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q21810", "WBGene00011102", "P92005", "WBGene00000789", "Q9XWA4", "WBGene00013764", "Q18740", "WBGene00008231", "Q9XXQ7", "WBGene00013764", "G5EGP8", "WBGene00000788", "Q9U2X1", "WBGene00013764", "Q22361", "WBGene00011648", "Q10914", "WBGene00001613", "Q21415", "WBGene00001614", "Q8MXV8", "WBGene00001617", "P34299", "WBGene00001612", "Q23445", "WBGene00022678", "species_29438", "Q9U1W1", "WBGene00006565", "H2KZQ8", "WBGene00017419", "P34643", "WBGene00013985", "H2KZQ8", "WBGene00017419", "P34643", "WBGene00013985", "Q9U1W1", "WBGene00006565", "Q23368", "WBGene00004756", "Q19371", "WBGene00004755", "Q9U2Z1", "WBGene00004754", "P41941", "WBGene00007128", "Q20797", "WBGene00006373", "G5EDE8", "WBGene00002070", "A9Z1L1", "WBGene00005648", "Q19651", "WBGene00005649", "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q21810", "WBGene00011102", "P92005", "WBGene00000789", "Q9XWA4", "WBGene00013764", "Q18740", "WBGene00008231", "Q9XXQ7", "WBGene00013764", "G5EGP8", "WBGene00000788", "Q9U2X1", "WBGene00013764", "Q22361", "WBGene00011648", "Q10914", "WBGene00001613", "Q21415", "WBGene00001614", "Q8MXV8", "WBGene00001617", "P34299", "WBGene00001612", "Q23445", "WBGene00022678", "species_29438" ] }, "reaction_10515948": { "compartment": "compartment_70101", "id": "reaction_10515948", "reactome": "R-CEL-203977", "name": "SAR1 Activation And Membrane Binding", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10515940" ], "products": [ "species_10515678", "species_29420" ], "modifiers": [ [ "species_10515945", "catalyst" ] ], "additional_components": [ "species_29420", "Q23445", "WBGene00022678", "Q23445", "WBGene00022678", "species_29438", "WBGene00010496" ] }, "reaction_10564493": { "compartment": "compartment_6791047", "id": "reaction_10564493", "reactome": "R-CEL-6814831", "name": "TBC1D20 binds RAB1:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10564489", "species_10563177" ], "products": [ "species_10564491" ], "modifiers": [], "additional_components": [ "WBGene00013196", "Q9UAQ6", "WBGene00004266", "species_29438", "Q9UAQ6", "WBGene00004266", "species_29438", "Q9XWI2", "WBGene00013196" ] }, "reaction_10564496": { "compartment": "compartment_6791047", "id": "reaction_10564496", "reactome": "R-CEL-6814833", "name": "TBC1D20 stimulates GTPase activity of RAB1, resulting in hydrolysis of GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10564491" ], "products": [ "species_10557214", "species_10564489" ], "modifiers": [ [ "species_10564491", "catalyst" ] ], "additional_components": [ "Q9UAQ6", "WBGene00004266", "species_29438", "Q9XWI2", "WBGene00013196", "Q9UAQ6", "WBGene00004266", "species_29420", "WBGene00013196", "Q9UAQ6", "WBGene00004266", "species_29438", "Q9XWI2", "WBGene00013196" ] }, "reaction_10557460": { "compartment": "compartment_6791047", "id": "reaction_10557460", "reactome": "R-CEL-5694446", "name": "BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10557386", "species_10557361" ], "products": [ "species_10557295", "species_10557369", "species_10557302", "species_10557458" ], "modifiers": [], "additional_components": [ "Q94241", "WBGene00018853", "G5EGG0", "WBGene00010713", "Q10914", "WBGene00001613", "Q21415", "WBGene00001614", "Q8MXV8", "WBGene00001617", "P34299", "WBGene00001612", "Q22361", "WBGene00011648", "Q9U2Z1", "WBGene00004754", "P41941", "WBGene00007128", "Q20797", "WBGene00006373", "Q19371", "WBGene00004755", "G5EDE8", "WBGene00002070", "Q9U2X1", "WBGene00013764", "Q9XWA4", "WBGene00013764", "Q9XXQ7", "WBGene00013764", "G5EGP8", "WBGene00000788", "P92005", "WBGene00000789", "Q18740", "WBGene00008231", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "A9Z1L1", "WBGene00005648", "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "Q21810", "WBGene00011102", "Q19989", "WBGene00018017", "Q9N3Y1", "WBGene00021536", "G5EEU1", "WBGene00043064", "P41941", "WBGene00007128", "Q20364", "WBGene00009654", "Q20797", "WBGene00006373", "Q19989", "WBGene00018017", "Q9N3Y1", "WBGene00021536", "G5EEU1", "WBGene00043064", "P41941", "WBGene00007128", "Q20364", "WBGene00009654", "Q20797", "WBGene00006373", "Q94241", "WBGene00018853", "G5EGG0", "WBGene00010713", "Q22361", "WBGene00011648", "P34299", "WBGene00001612", "Q10914", "WBGene00001613", "Q21415", "WBGene00001614", "Q8MXV8", "WBGene00001617", "Q9U2Z1", "WBGene00004754", "P41941", "WBGene00007128", "Q20797", "WBGene00006373", "Q19371", "WBGene00004755", "Q21810", "WBGene00011102", "G5EGP8", "WBGene00000788", "P92005", "WBGene00000789", "Q18740", "WBGene00008231", "Q9U2X1", "WBGene00013764", "Q9XWA4", "WBGene00013764", "Q9XXQ7", "WBGene00013764", "A9Z1L1", "WBGene00005648", "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "G5EDE8", "WBGene00002070" ] }, "reaction_10557272": { "compartment": "compartment_13959", "id": "reaction_10557272", "reactome": "R-CEL-5694409", "name": "Nucleotide exchange on RAB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10557265" ], "products": [ "species_29420", "species_10557269" ], "modifiers": [ [ "species_10557265", "catalyst" ] ], "additional_components": [ "Q94241", "WBGene00018853", "Q23368", "WBGene00004756", "Q19371", "WBGene00004755", "Q9U2Z1", "WBGene00004754", "Q10914", "WBGene00001613", "Q21415", "WBGene00001614", "Q8MXV8", "WBGene00001617", "P34299", "WBGene00001612", "Q22361", "WBGene00011648", "P41941", "WBGene00007128", "Q20797", "WBGene00006373", "G5EDE8", "WBGene00002070", "Q9U2X1", "WBGene00013764", "Q9XWA4", "WBGene00013764", "Q9XXQ7", "WBGene00013764", "G5EGP8", "WBGene00000788", "P92005", "WBGene00000789", "Q18740", "WBGene00008231", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "A9Z1L1", "WBGene00005648", "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "Q21810", "WBGene00011102", "G5EFY6", "WBGene00011338", "Q9N4A7", "WBGene00003806", "Q9NA81", "WBGene00013259", "B1GRL5", "WBGene00077643", "G4SNB8", "WBGene00044604", "P34605", "WBGene00014222", "Q93330", "WBGene00007956", "B1V899", "WBGene00022138", "Q9XU81", "WBGene00010699", "O02173", "WBGene00021046", "Q20100", "WBGene00018088", "Q9UAQ6", "WBGene00004266", "species_29420", "Q9UAQ6", "WBGene00004266", "species_29438", "Q94241", "WBGene00018853", "Q23368", "WBGene00004756", "Q19371", "WBGene00004755", "Q9U2Z1", "WBGene00004754", "Q10914", "WBGene00001613", "Q21415", "WBGene00001614", "Q8MXV8", "WBGene00001617", "P34299", "WBGene00001612", "Q22361", "WBGene00011648", "P41941", "WBGene00007128", "Q20797", "WBGene00006373", "G5EDE8", "WBGene00002070", "Q9U2X1", "WBGene00013764", "Q9XWA4", "WBGene00013764", "Q9XXQ7", "WBGene00013764", "G5EGP8", "WBGene00000788", "P92005", "WBGene00000789", "Q18740", "WBGene00008231", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "A9Z1L1", "WBGene00005648", "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "Q21810", "WBGene00011102", "G5EFY6", "WBGene00011338", "Q9N4A7", "WBGene00003806", "Q9NA81", "WBGene00013259", "B1GRL5", "WBGene00077643", "G4SNB8", "WBGene00044604", "P34605", "WBGene00014222", "Q93330", "WBGene00007956", "B1V899", "WBGene00022138", "Q9XU81", "WBGene00010699", "O02173", "WBGene00021046", "Q20100", "WBGene00018088", "Q94241", "WBGene00018853", "Q23368", "WBGene00004756", "Q19371", "WBGene00004755", "Q9U2Z1", "WBGene00004754", "Q10914", "WBGene00001613", "Q21415", "WBGene00001614", "Q8MXV8", "WBGene00001617", "P34299", "WBGene00001612", "Q22361", "WBGene00011648", "P41941", "WBGene00007128", "Q20797", "WBGene00006373", "G5EDE8", "WBGene00002070", "Q9U2X1", "WBGene00013764", "Q9XWA4", "WBGene00013764", "Q9XXQ7", "WBGene00013764", "G5EGP8", "WBGene00000788", "P92005", "WBGene00000789", "Q18740", "WBGene00008231", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "A9Z1L1", "WBGene00005648", "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "Q21810", "WBGene00011102", "G5EFY6", "WBGene00011338", "Q9N4A7", "WBGene00003806", "Q9NA81", "WBGene00013259", "B1GRL5", "WBGene00077643", "G4SNB8", "WBGene00044604", "P34605", "WBGene00014222", "Q93330", "WBGene00007956", "B1V899", "WBGene00022138", "Q9XU81", "WBGene00010699", "O02173", "WBGene00021046", "Q20100", "WBGene00018088", "Q9UAQ6", "WBGene00004266", "species_29420" ] }, "reaction_10557373": { "compartment": "compartment_6791047", "id": "reaction_10557373", "reactome": "R-CEL-5694423", "name": "NSF and SNAPs bind cis-SNARE complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10557369", "species_10557345", "species_10557329" ], "products": [ "species_10557371" ], "modifiers": [], "additional_components": [ "G5EEU1", "WBGene00043064", "P41941", "WBGene00007128", "Q20364", "WBGene00009654", "Q20797", "WBGene00006373", "Q94241", "WBGene00018853", "Q18921", "WBGene00017016", "Q94392", "WBGene00003818", "Q94392", "WBGene00003818", "Q18921", "WBGene00017016", "G5EEU1", "WBGene00043064", "P41941", "WBGene00007128", "Q20364", "WBGene00009654", "Q20797", "WBGene00006373", "Q94241", "WBGene00018853" ] }, "reaction_10557310": { "compartment": "compartment_20699", "id": "reaction_10557310", "reactome": "R-CEL-5694418", "name": "RAB1:GTP binds USO1 and GORASP1:GOLGA2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10557295", "species_10557302", "species_10557269" ], "products": [ "species_10557308" ], "modifiers": [], "additional_components": [ "Q19989", "WBGene00018017", "Q9N3Y1", "WBGene00021536", "G5EGG0", "WBGene00010713", "Q9UAQ6", "WBGene00004266", "species_29438", "Q94241", "WBGene00018853", "Q23368", "WBGene00004756", "Q19371", "WBGene00004755", "Q9U2Z1", "WBGene00004754", "Q10914", "WBGene00001613", "Q21415", "WBGene00001614", "Q8MXV8", "WBGene00001617", "P34299", "WBGene00001612", "Q22361", "WBGene00011648", "P41941", "WBGene00007128", "Q20797", "WBGene00006373", "G5EDE8", "WBGene00002070", "Q9U2X1", "WBGene00013764", "Q9XWA4", "WBGene00013764", "Q9XXQ7", "WBGene00013764", "G5EGP8", "WBGene00000788", "P92005", "WBGene00000789", "Q18740", "WBGene00008231", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "A9Z1L1", "WBGene00005648", "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "Q21810", "WBGene00011102", "G5EFY6", "WBGene00011338", "Q9N4A7", "WBGene00003806", "Q9NA81", "WBGene00013259", "B1GRL5", "WBGene00077643", "G4SNB8", "WBGene00044604", "P34605", "WBGene00014222", "Q93330", "WBGene00007956", "B1V899", "WBGene00022138", "Q9XU81", "WBGene00010699", "O02173", "WBGene00021046", "Q20100", "WBGene00018088", "Q9UAQ6", "WBGene00004266", "species_29438", "Q94241", "WBGene00018853", "Q23368", "WBGene00004756", "Q19371", "WBGene00004755", "Q9U2Z1", "WBGene00004754", "Q10914", "WBGene00001613", "Q21415", "WBGene00001614", "Q8MXV8", "WBGene00001617", "P34299", "WBGene00001612", "Q22361", "WBGene00011648", "P41941", "WBGene00007128", "Q20797", "WBGene00006373", "G5EDE8", "WBGene00002070", "Q9U2X1", "WBGene00013764", "Q9XWA4", "WBGene00013764", "Q9XXQ7", "WBGene00013764", "G5EGP8", "WBGene00000788", "P92005", "WBGene00000789", "Q18740", "WBGene00008231", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "A9Z1L1", "WBGene00005648", "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "Q21810", "WBGene00011102", "G5EFY6", "WBGene00011338", "Q9N4A7", "WBGene00003806", "Q9NA81", "WBGene00013259", "B1GRL5", "WBGene00077643", "G4SNB8", "WBGene00044604", "P34605", "WBGene00014222", "Q93330", "WBGene00007956", "B1V899", "WBGene00022138", "Q9XU81", "WBGene00010699", "O02173", "WBGene00021046", "Q20100", "WBGene00018088", "G5EGG0", "WBGene00010713", "Q19989", "WBGene00018017", "Q9N3Y1", "WBGene00021536" ] }, "reaction_10521505": { "compartment": "compartment_876", "id": "reaction_10521505", "reactome": "R-CEL-400071", "name": "Alpha-2A,alpha-2C Adrenergic Receptors bind adrenaline or noradrenaline", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_390627", "species_10519747" ], "products": [ "species_10519749" ], "modifiers": [], "additional_components": [ "species_209794", "species_209789", "O02213", "WBGene00004777", "Q19084", "WBGene00017157", "O02213", "WBGene00004777", "Q19084", "WBGene00017157", "species_209794", "species_209789" ] }, "reaction_10521511": { "compartment": "compartment_876", "id": "reaction_10521511", "reactome": "R-CEL-400092", "name": "Alpha-2A,alpha-2C Adrenergic Receptors activate Gi.Go heterotrimeric G proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10521509" ], "products": [ "species_10521501", "species_29420" ], "modifiers": [ [ "species_10519749", "catalyst" ] ], "additional_components": [ "species_29420", "species_29438", "O02213", "WBGene00004777", "Q19084", "WBGene00017157", "species_209794", "species_209789" ] }, "reaction_10521518": { "compartment": "compartment_876", "id": "reaction_10521518", "reactome": "R-CEL-400097", "name": "G-beta:G-gamma inhibits Adenylate cyclase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10521499", "species_10521514" ], "products": [ "species_10521516" ], "modifiers": [], "additional_components": [] }, "reaction_10521503": { "compartment": "compartment_876", "id": "reaction_10521503", "reactome": "R-CEL-400037", "name": "Gi,Go Heterotrimeric G-protein complex dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10521501" ], "products": [ "species_10521499", "species_10521493" ], "modifiers": [], "additional_components": [ "species_29438", "species_29438" ] }, "reaction_10571830": { "compartment": "compartment_17963", "id": "reaction_10571830", "reactome": "R-CEL-9036987", "name": "FUT2 transfers Fuc to Type 1 chains to form H antigen-sec", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9036984", "species_205683" ], "products": [ "species_205689", "species_9037036" ], "modifiers": [ [ "species_10571827", "catalyst" ] ], "additional_components": [ "WBGene00015019" ] }, "reaction_10571804": { "compartment": "compartment_17963", "id": "reaction_10571804", "reactome": "R-CEL-9033949", "name": "FUT1 transfers Fuc to Type 2 chains to form H antigen-RBC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9033790", "species_205683" ], "products": [ "species_205689", "species_9033793" ], "modifiers": [ [ "species_10571801", "catalyst" ] ], "additional_components": [ "WBGene00015019" ] }, "reaction_10563778": { "compartment": "compartment_7660", "id": "reaction_10563778", "reactome": "R-CEL-6810238", "name": "RNA polymerase II binds initiation factors at promoter of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10504431", "species_10563743" ], "products": [ "species_10563741" ], "modifiers": [], "additional_components": [ "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "G5EG49", "WBGene00013998", "G5EG47", "WBGene00010054", "O44625", "WBGene00004136", "Q9NEX2", "WBGene00013736", "Q9TVL3", "WBGene00000410", "P34424", "WBGene00000508", "P34425", "WBGene00000507", "O17869", "WBGene00009650", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "O16991", "WBGene00006648", "Q9XW26", "WBGene00012735", "P91868", "WBGene00001568", "Q17694", "WBGene00015513", "G5EFV5", "WBGene00000408", "Q17957", "WBGene00006397", "Q9GZI6", "WBGene00006387", "Q7YTH5", "WBGene00006390", "G5EF68", "WBGene00006386", "O45784", "WBGene00006391", "Q20361", "WBGene00006395", "P32085", "WBGene00006542", "Q9XW26", "WBGene00012735", "P91868", "WBGene00001568", "Q17694", "WBGene00015513", "G5EG49", "WBGene00013998", "G5EG47", "WBGene00010054", "Q9TVL3", "WBGene00000410", "P34424", "WBGene00000508", "P34425", "WBGene00000507", "O17869", "WBGene00009650", "O44625", "WBGene00004136", "Q9NEX2", "WBGene00013736", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "O16991", "WBGene00006648", "G5EFV5", "WBGene00000408", "Q17957", "WBGene00006397", "Q9GZI6", "WBGene00006387", "Q7YTH5", "WBGene00006390", "G5EF68", "WBGene00006386", "O45784", "WBGene00006391", "Q20361", "WBGene00006395", "P32085", "WBGene00006542", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140" ] }, "reaction_10564498": { "compartment": "compartment_7660", "id": "reaction_10564498", "reactome": "R-CEL-6814885", "name": "CBCAP complex binds 7-methylguanosine cap of snRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10504700", "species_10504346", "species_10564404", "species_10513169" ], "products": [ "species_10564380" ], "modifiers": [], "additional_components": [ "WBGene00017085", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "A5Z2V1", "WBGene00009451", "P34281", "WBGene00015347", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q9N554", "WBGene00021281", "Q22805", "WBGene00020827", "Q9U3K2", "WBGene00008642", "B7WN63", "WBGene00000994", "O01483", "WBGene00015499", "G5EDW9", "WBGene00008361", "H2KML7", "WBGene00013021", "E5QCH1", "WBGene00013877", "Q95ZM2", "WBGene00017608", "W6RQY9", "WBGene00022360", "O18167", "WBGene00012234", "Q17749", "WBGene00015554", "O44500", "WBGene00019822", "Q9U267", "WBGene00013075", "P30641", "WBGene00011143", "species_430042", "G5EG49", "WBGene00013998", "G5EG47", "WBGene00010054", "O44625", "WBGene00004136", "Q9NEX2", "WBGene00013736", "Q9TVL3", "WBGene00000410", "P34424", "WBGene00000508", "P34425", "WBGene00000507", "O17869", "WBGene00009650", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "O16991", "WBGene00006648", "Q9XW26", "WBGene00012735", "P91868", "WBGene00001568", "Q17694", "WBGene00015513", "G5EFV5", "WBGene00000408", "Q17957", "WBGene00006397", "Q9GZI6", "WBGene00006387", "Q7YTH5", "WBGene00006390", "G5EF68", "WBGene00006386", "O45784", "WBGene00006391", "Q20361", "WBGene00006395", "P32085", "WBGene00006542", "WBGene00022192", "A5Z2V1", "WBGene00009451", "P34281", "WBGene00015347", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q9N554", "WBGene00021281", "Q22805", "WBGene00020827", "Q9U3K2", "WBGene00008642", "B7WN63", "WBGene00000994", "O01483", "WBGene00015499", "G5EDW9", "WBGene00008361", "H2KML7", "WBGene00013021", "E5QCH1", "WBGene00013877", "Q95ZM2", "WBGene00017608", "W6RQY9", "WBGene00022360", "O18167", "WBGene00012234", "Q17749", "WBGene00015554", "O44500", "WBGene00019822", "Q9U267", "WBGene00013075", "P30641", "WBGene00011143", "Q9N4E8", "WBGene00022192", "species_430042", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "Q966L5", "WBGene00017085", "G5EG49", "WBGene00013998", "G5EG47", "WBGene00010054", "O44625", "WBGene00004136", "Q9NEX2", "WBGene00013736", "Q9TVL3", "WBGene00000410", "P34424", "WBGene00000508", "P34425", "WBGene00000507", "O17869", "WBGene00009650", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "O16991", "WBGene00006648", "Q9XW26", "WBGene00012735", "P91868", "WBGene00001568", "Q17694", "WBGene00015513", "G5EFV5", "WBGene00000408", "Q17957", "WBGene00006397", "Q9GZI6", "WBGene00006387", "Q7YTH5", "WBGene00006390", "G5EF68", "WBGene00006386", "O45784", "WBGene00006391", "Q20361", "WBGene00006395", "P32085", "WBGene00006542" ] }, "reaction_10564407": { "compartment": "compartment_7660", "id": "reaction_10564407", "reactome": "R-CEL-6814559", "name": "Pre-snRNA is elongated and capped with 7-methylguanosine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29470", "species_29358", "species_113562", "species_10564402", "species_113571" ], "products": [ "species_10564404" ], "modifiers": [ [ "species_10564402", "catalyst" ], [ "species_10564402", "catalyst" ] ], "additional_components": [ "A5Z2V1", "WBGene00009451", "P34281", "WBGene00015347", "Q9N554", "WBGene00021281", "Q22805", "WBGene00020827", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "P16356", "WBGene00000123", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q9U3K2", "WBGene00008642", "B7WN63", "WBGene00000994", "O01483", "WBGene00015499", "G5EDW9", "WBGene00008361", "H2KML7", "WBGene00013021", "E5QCH1", "WBGene00013877", "Q95ZM2", "WBGene00017608", "W6RQY9", "WBGene00022360", 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"WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q9U3K2", "WBGene00008642", "B7WN63", "WBGene00000994", "O01483", "WBGene00015499", "G5EDW9", "WBGene00008361", "H2KML7", "WBGene00013021", "E5QCH1", "WBGene00013877", "Q95ZM2", "WBGene00017608", "W6RQY9", "WBGene00022360", "O18167", "WBGene00012234", "Q17749", "WBGene00015554", "O44500", "WBGene00019822", "Q9U267", "WBGene00013075", "P30641", "WBGene00011143", "G5EG49", "WBGene00013998", "G5EG47", "WBGene00010054", "O44625", "WBGene00004136", "Q9NEX2", "WBGene00013736", "Q9TVL3", "WBGene00000410", "P34424", "WBGene00000508", "P34425", "WBGene00000507", "O17869", "WBGene00009650", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "O16991", "WBGene00006648", "Q9XW26", "WBGene00012735", "P91868", "WBGene00001568", "Q17694", "WBGene00015513", "G5EFV5", "WBGene00000408", "Q17957", "WBGene00006397", "Q9GZI6", "WBGene00006387", "Q7YTH5", "WBGene00006390", "G5EF68", "WBGene00006386", "O45784", "WBGene00006391", "Q20361", "WBGene00006395", "P32085", "WBGene00006542" ] }, "reaction_10563753": { "compartment": "compartment_7660", "id": "reaction_10563753", "reactome": "R-CEL-6810233", "name": "CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10563741" ], "products": [ "species_113582", "species_10563750" ], "modifiers": [ [ "species_10563741", "catalyst" ] ], "additional_components": [ "Q9XW26", "WBGene00012735", "P91868", "WBGene00001568", "Q17694", "WBGene00015513", "G5EG49", "WBGene00013998", "G5EG47", "WBGene00010054", "Q9TVL3", "WBGene00000410", "P34424", "WBGene00000508", "P34425", "WBGene00000507", "O17869", "WBGene00009650", "O44625", "WBGene00004136", "Q9NEX2", "WBGene00013736", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "O16991", "WBGene00006648", "G5EFV5", "WBGene00000408", "Q17957", "WBGene00006397", "Q9GZI6", "WBGene00006387", "Q7YTH5", "WBGene00006390", "G5EF68", "WBGene00006386", "O45784", "WBGene00006391", "Q20361", "WBGene00006395", "P32085", "WBGene00006542", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "P16356", "WBGene00000123", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "G5EG49", "WBGene00013998", "G5EG47", "WBGene00010054", "O44625", "WBGene00004136", "Q9NEX2", "WBGene00013736", "Q9TVL3", "WBGene00000410", "P34424", "WBGene00000508", "P34425", "WBGene00000507", "O17869", "WBGene00009650", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "O16991", "WBGene00006648", "Q9XW26", "WBGene00012735", "P91868", "WBGene00001568", "Q17694", "WBGene00015513", "G5EFV5", "WBGene00000408", "Q17957", "WBGene00006397", "Q9GZI6", "WBGene00006387", "Q7YTH5", "WBGene00006390", "G5EF68", "WBGene00006386", "O45784", "WBGene00006391", "Q20361", "WBGene00006395", "P32085", "WBGene00006542", "Q9XW26", "WBGene00012735", "P91868", "WBGene00001568", "Q17694", "WBGene00015513", "G5EG49", "WBGene00013998", "G5EG47", "WBGene00010054", "Q9TVL3", "WBGene00000410", "P34424", "WBGene00000508", "P34425", "WBGene00000507", "O17869", "WBGene00009650", "O44625", "WBGene00004136", "Q9NEX2", "WBGene00013736", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "O16991", "WBGene00006648", "G5EFV5", "WBGene00000408", "Q17957", "WBGene00006397", "Q9GZI6", "WBGene00006387", "Q7YTH5", "WBGene00006390", "G5EF68", "WBGene00006386", "O45784", "WBGene00006391", "Q20361", "WBGene00006395", "P32085", "WBGene00006542", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140" ] }, "reaction_10564396": { "compartment": "compartment_7660", "id": "reaction_10564396", "reactome": "R-CEL-6814555", "name": "Integrator complex processes the 3' end of snRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10564380" ], "products": [ "species_10564382", "species_10564388" ], "modifiers": [ [ "species_10564380", "catalyst" ], [ "species_10505223", "catalyst" ], [ "species_10564394", "catalyst" ] ], "additional_components": [ "A5Z2V1", "WBGene00009451", "P34281", "WBGene00015347", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q9N554", "WBGene00021281", "Q22805", "WBGene00020827", "Q9U3K2", "WBGene00008642", "B7WN63", "WBGene00000994", "O01483", "WBGene00015499", "G5EDW9", "WBGene00008361", "H2KML7", "WBGene00013021", "E5QCH1", "WBGene00013877", "Q95ZM2", "WBGene00017608", "W6RQY9", "WBGene00022360", "O18167", "WBGene00012234", "Q17749", "WBGene00015554", "O44500", "WBGene00019822", "Q9U267", "WBGene00013075", "P30641", "WBGene00011143", "Q9N4E8", "WBGene00022192", "species_430042", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "Q966L5", "WBGene00017085", "G5EG49", "WBGene00013998", "G5EG47", "WBGene00010054", "O44625", "WBGene00004136", "Q9NEX2", "WBGene00013736", "Q9TVL3", "WBGene00000410", "P34424", "WBGene00000508", "P34425", "WBGene00000507", "O17869", "WBGene00009650", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "O16991", "WBGene00006648", "Q9XW26", "WBGene00012735", "P91868", "WBGene00001568", "Q17694", "WBGene00015513", "G5EFV5", "WBGene00000408", "Q17957", "WBGene00006397", "Q9GZI6", "WBGene00006387", "Q7YTH5", "WBGene00006390", "G5EF68", "WBGene00006386", "O45784", "WBGene00006391", "Q20361", "WBGene00006395", "P32085", "WBGene00006542", "A5Z2V1", "WBGene00009451", "P34281", "WBGene00015347", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", 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"H2KML7", "WBGene00013021", "E5QCH1", "WBGene00013877", "Q95ZM2", "WBGene00017608", "W6RQY9", "WBGene00022360", "O18167", "WBGene00012234", "Q17749", "WBGene00015554", "O44500", "WBGene00019822", "Q9U267", "WBGene00013075", "P30641", "WBGene00011143", "Q9N4E8", "WBGene00022192", "species_430042", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "Q966L5", "WBGene00017085", "G5EG49", "WBGene00013998", "G5EG47", "WBGene00010054", "O44625", "WBGene00004136", "Q9NEX2", "WBGene00013736", "Q9TVL3", "WBGene00000410", "P34424", "WBGene00000508", "P34425", "WBGene00000507", "O17869", "WBGene00009650", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "O16991", "WBGene00006648", "Q9XW26", "WBGene00012735", "P91868", "WBGene00001568", "Q17694", "WBGene00015513", "G5EFV5", "WBGene00000408", "Q17957", "WBGene00006397", "Q9GZI6", "WBGene00006387", "Q7YTH5", "WBGene00006390", "G5EF68", "WBGene00006386", "O45784", "WBGene00006391", "Q20361", "WBGene00006395", "P32085", "WBGene00006542", "WBGene00020092", "WBGene00020480" ] }, "reaction_10548576": { "compartment": "compartment_876", "id": "reaction_10548576", "reactome": "R-CEL-3928591", "name": "EPH:EFN tetramers oligomerise", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10548574", "species_10548572" ], "products": [ "species_10548507" ], "modifiers": [], "additional_components": [ "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "O61460", "WBGene00006868", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "O61460", "WBGene00006868", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "O61460", "WBGene00006868" ] }, "reaction_10548786": { "compartment": "compartment_876", "id": "reaction_10548786", "reactome": "R-CEL-3928646", "name": "EPHAs bind EFNAs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10548447", "species_10548442" ], "products": [ "species_10548465" ], "modifiers": [], "additional_components": [ "WBGene00006868", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "O61460", "WBGene00006868" ] }, "reaction_10549059": { "compartment": "compartment_876", "id": "reaction_10549059", "reactome": "R-CEL-4093342", "name": "SDC2 multimerises", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10549032" ], "products": [ "species_10549057" ], "modifiers": [], "additional_components": [ "WBGene00004749", "P50605", "WBGene00004749" ] }, "reaction_10548585": { "compartment": "compartment_70101", "id": "reaction_10548585", "reactome": "R-CEL-3928592", "name": "p190RhoGEF exchanges GTP for GDP on RHOA, activating it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509486", "species_29438" ], "products": [ "species_29420", "species_10509488" ], "modifiers": [ [ "species_10548582", "catalyst" ] ], "additional_components": [ "Q22038", "WBGene00004357", "species_29420", "Q22038", "WBGene00004357", "species_29438", "A0A0K3AQN0", "WBGene00013682", "O61460", "WBGene00006868", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "Q95YD4", "WBGene00002213" ] }, "reaction_10548714": { "compartment": "compartment_70101", "id": "reaction_10548714", "reactome": "R-CEL-3928620", "name": "PAK1 autophosphorylates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10548701", "species_113592" ], "products": [ "species_29370", "species_10548711" ], "modifiers": [ [ "species_10548701", "catalyst" ] ], "additional_components": [ "Q03206", "ced-10", "species_29438", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "Q03206", "ced-10", "species_29438", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "Q03206", "ced-10", "species_29438", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911" ] }, "reaction_10549035": { "compartment": "compartment_876", "id": "reaction_10549035", "reactome": "R-CEL-4093332", "name": "p-EPHB phosphorylates SDC2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10537380" ], "products": [ "species_29370", "species_10549032" ], "modifiers": [ [ "species_10548561", "catalyst" ] ], "additional_components": [ "WBGene00004749", "WBGene00004749", "O61460", "WBGene00006868", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869" ] }, "reaction_10549038": { "compartment": "compartment_876", "id": "reaction_10549038", "reactome": "R-CEL-4093336", "name": "p-TIAM1 exchanges GTP for GDP on RAC1, activating it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10520575", "species_29438" ], "products": [ "species_29420", "species_10509457" ], "modifiers": [ [ "species_10548757", "catalyst" ] ], "additional_components": [ "species_29420", "Q03206", "ced-10", "species_29438", "Q03206", "ced-10", "O01847", "WBGene00015704", "O61460", "WBGene00006868", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "Q9N3S5", "WBGene00021635", "G5EE56", "WBGene00005077", "G5EGQ9", "WBGene00003774", "species_159549", "G5EEH3", "WBGene00003775", "species_113552" ] }, "reaction_10548784": { "compartment": "compartment_70101", "id": "reaction_10548784", "reactome": "R-CEL-3928645", "name": "EPHB:NMDAR binds TIAM1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10548750", "species_10516084" ], "products": [ "species_10548752" ], "modifiers": [], "additional_components": [ "O61460", "WBGene00006868", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "Q9N3S5", "WBGene00021635", "G5EE56", "WBGene00005077", "G5EGQ9", "WBGene00003774", "species_159549", "G5EEH3", "WBGene00003775", "species_113552", "WBGene00015704", "O01847", "WBGene00015704", "O61460", "WBGene00006868", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "Q9N3S5", "WBGene00021635", "G5EE56", "WBGene00005077", "G5EGQ9", "WBGene00003774", "species_159549", "G5EEH3", "WBGene00003775", "species_113552" ] }, "reaction_10548599": { "compartment": "compartment_876", "id": "reaction_10548599", "reactome": "R-CEL-3928595", "name": "N-WASP binds ARP2/3 and G-actin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10537823", "species_10515381", "species_10548595" ], "products": [ "species_10548597" ], "modifiers": [], "additional_components": [ "P58798", "WBGene00000204", "A0A3P6PCS5", "WBGene00000201", "Q9N4I0", "WBGene00000199", "species_29358", "Q8WTM6", "WBGene00021170", "P53489", "WBGene00000200", "Q9XWV3", "WBGene00000203", "O61861", "WBGene00000205", "P91167", "WBGene00016729", "P0DM41", "WBGene00000063", "P0DM42", "WBGene00000065", "P10984", "WBGene00000064", "P10986", "WBGene00000066", "species_29358", "Q05062", "WBGene00000390", "species_29438", "O61460", "WBGene00006868", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "A0A0K3AS36", "Y116A8C.36d", "species_179856", "Q05062", "WBGene00000390", "species_29438", "O61460", "WBGene00006868", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "A0A0K3AS36", "Y116A8C.36d", "species_179856", "P0DM41", "WBGene00000063", "P0DM42", "WBGene00000065", "P10984", "WBGene00000064", "P10986", "WBGene00000066", "species_29358", "P58798", "WBGene00000204", "A0A3P6PCS5", "WBGene00000201", "Q9N4I0", "WBGene00000199", "Q8WTM6", "WBGene00021170", "P53489", "WBGene00000200", "Q9XWV3", "WBGene00000203", "O61861", "WBGene00000205", "P91167", "WBGene00016729" ] }, "reaction_10548760": { "compartment": "compartment_70101", "id": "reaction_10548760", "reactome": "R-CEL-3928627", "name": "EPHB phosphorylates TIAM1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10548752" ], "products": [ "species_29370", "species_10548757" ], "modifiers": [ [ "species_10548752", "catalyst" ] ], "additional_components": [ "O01847", "WBGene00015704", "O61460", "WBGene00006868", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "Q9N3S5", "WBGene00021635", "G5EE56", "WBGene00005077", "G5EGQ9", "WBGene00003774", "species_159549", "G5EEH3", "WBGene00003775", "species_113552", "O01847", "WBGene00015704", "O61460", "WBGene00006868", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "Q9N3S5", "WBGene00021635", "G5EE56", "WBGene00005077", "G5EGQ9", "WBGene00003774", "species_159549", "G5EEH3", "WBGene00003775", "species_113552", "O01847", "WBGene00015704", "O61460", "WBGene00006868", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "Q9N3S5", "WBGene00021635", "G5EE56", "WBGene00005077", "G5EGQ9", "WBGene00003774", "species_159549", "G5EEH3", "WBGene00003775", "species_113552" ] }, "reaction_10548378": { "compartment": "compartment_876", "id": "reaction_10548378", "reactome": "R-CEL-3928576", "name": "RHOA:GTP binds ROCK, activating it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10521949", "species_10509488" ], "products": [ "species_10521951" ], "modifiers": [], "additional_components": [ "P92199", "WBGene00002694", "Q21025", "WBGene00019087", "Q9XVH4", "WBGene00019087", "Q22038", "WBGene00004357", "species_29438", "Q22038", "WBGene00004357", "species_29438", "P92199", "WBGene00002694", "Q21025", "WBGene00019087", "Q9XVH4", "WBGene00019087" ] }, "reaction_10548603": { "compartment": "compartment_70101", "id": "reaction_10548603", "reactome": "R-CEL-3928598", "name": "Recruitment of p190RhoGEF to p-FAK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10548580", "species_10548578" ], "products": [ "species_10548582" ], "modifiers": [], "additional_components": [ "O61460", "WBGene00006868", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "Q95YD4", "WBGene00002213", "WBGene00013682", "A0A0K3AQN0", "WBGene00013682", "O61460", "WBGene00006868", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "Q95YD4", "WBGene00002213" ] }, "reaction_10548605": { "compartment": "compartment_876", "id": "reaction_10548605", "reactome": "R-CEL-3928601", "name": "CDC42 and PIP2 bind WASL, activating it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179856", "species_10548593" ], "products": [ "species_10548595" ], "modifiers": [], "additional_components": [ "Q05062", "WBGene00000390", "species_29438", "O61460", "WBGene00006868", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "A0A0K3AS36", "Y116A8C.36d", "Q05062", "WBGene00000390", "species_29438", "O61460", "WBGene00006868", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "A0A0K3AS36", "Y116A8C.36d", "species_179856" ] }, "reaction_10548703": { "compartment": "compartment_876", "id": "reaction_10548703", "reactome": "R-CEL-3928619", "name": "PAK1 binds RAC1:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10516065", "species_10520672" ], "products": [ "species_10548701" ], "modifiers": [], "additional_components": [ "Q03206", "ced-10", "species_29438", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "Q03206", "ced-10", "species_29438", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911" ] }, "reaction_10549055": { "compartment": "compartment_876", "id": "reaction_10549055", "reactome": "R-CEL-4093339", "name": "p120-RasGAP activates GTP hydrolysis on RAS, inactivating it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10549048" ], "products": [ "species_29372", "species_10549052" ], "modifiers": [ [ "species_10549048", "catalyst" ] ], "additional_components": [ "O61460", "WBGene00006868", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "P22981", "WBGene00002335", "species_29438", "O61460", "WBGene00006868", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "P22981", "WBGene00002335", "species_29420", "O61460", "WBGene00006868", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "P22981", "WBGene00002335", "species_29438" ] }, "reaction_10548566": { "compartment": "compartment_70101", "id": "reaction_10548566", "reactome": "R-CEL-3928578", "name": "EPH receptors autophosphorylate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10548507", "species_113592" ], "products": [ "species_29370", "species_10548563" ], "modifiers": [ [ "species_10548507", "catalyst" ] ], "additional_components": [ "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "O61460", "WBGene00006868", "O61460", "WBGene00006868", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "O61460", "WBGene00006868" ] }, "reaction_10548601": { "compartment": "compartment_876", "id": "reaction_10548601", "reactome": "R-CEL-3928597", "name": "EPH:EFN dimers tetramerise", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10548574" ], "products": [ "species_10548572" ], "modifiers": [], "additional_components": [ "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "O61460", "WBGene00006868", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "O61460", "WBGene00006868" ] }, "reaction_10548768": { "compartment": "compartment_876", "id": "reaction_10548768", "reactome": "R-CEL-3928633", "name": "bPIX exchanges GTP for GDP on RAC, activating it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10516063", "species_29438", "species_10548718" ], "products": [ "species_114549", "species_10548720" ], "modifiers": [ [ "species_10548718", "catalyst" ] ], "additional_components": [ "species_29420", "Q03206", "ced-10", "Q21430", "WBGene00010776", "O61460", "WBGene00006868", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q95PX0", "WBGene00006410", "Q19467", "WBGene00008805", "Q03206", "ced-10", "species_29438", "Q21430", "WBGene00010776", "O61460", "WBGene00006868", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q95PX0", "WBGene00006410", "Q19467", "WBGene00008805", "Q21430", "WBGene00010776", "O61460", "WBGene00006868", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q95PX0", "WBGene00006410", "Q19467", "WBGene00008805" ] }, "reaction_10548770": { "compartment": "compartment_70101", "id": "reaction_10548770", "reactome": "R-CEL-3928639", "name": "p-EFNB binds GRB4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10518535", "species_10548675" ], "products": [ "species_10548677" ], "modifiers": [], "additional_components": [ "WBGene00006410", "O61460", "WBGene00006868", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "O61460", "WBGene00006868", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q95PX0", "WBGene00006410" ] }, "reaction_10548691": { "compartment": "compartment_70101", "id": "reaction_10548691", "reactome": "R-CEL-3928615", "name": "EFNBs bind SFKs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10548620", "species_10548503" ], "products": [ "species_10548689" ], "modifiers": [], "additional_components": [ "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "O61460", "WBGene00006868", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "O61460", "WBGene00006868", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635" ] }, "reaction_10548739": { "compartment": "compartment_70101", "id": "reaction_10548739", "reactome": "R-CEL-3928625", "name": "PAKs autophosphorylate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10548724" ], "products": [ "species_29370", "species_10548736" ], "modifiers": [ [ "species_10548724", "catalyst" ] ], "additional_components": [ "Q03206", "ced-10", "species_29438", "Q21430", "WBGene00010776", "O61460", "WBGene00006868", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q95PX0", "WBGene00006410", "Q19467", "WBGene00008805", "Q17850", "WBGene00003911", "G5EGQ3", "WBGene00003144", "Q03206", "ced-10", "species_29438", "Q21430", "WBGene00010776", "O61460", "WBGene00006868", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q95PX0", "WBGene00006410", "Q19467", "WBGene00008805", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "Q03206", "ced-10", "species_29438", "Q21430", "WBGene00010776", "O61460", "WBGene00006868", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q95PX0", "WBGene00006410", "Q19467", "WBGene00008805", "Q17850", "WBGene00003911", "G5EGQ3", "WBGene00003144" ] }, "reaction_10548773": { "compartment": "compartment_70101", "id": "reaction_10548773", "reactome": "R-CEL-3928640", "name": "PAKs phosphorylate MLC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10525019", "species_113592" ], "products": [ "species_29370", "species_10524835" ], "modifiers": [ [ "species_10548736", "catalyst" ] ], "additional_components": [ "WBGene00003372", "WBGene00003372", "Q03206", "ced-10", "species_29438", "Q21430", "WBGene00010776", "O61460", "WBGene00006868", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q95PX0", "WBGene00006410", "Q19467", "WBGene00008805", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911" ] }, "reaction_10548775": { "compartment": "compartment_70101", "id": "reaction_10548775", "reactome": "R-CEL-3928641", "name": "PAK binds RAC and bPIX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10548722", "species_10548720" ], "products": [ "species_10548724" ], "modifiers": [], "additional_components": [ "Q17850", "WBGene00003911", "G5EGQ3", "WBGene00003144", "Q03206", "ced-10", "species_29438", "Q21430", "WBGene00010776", "O61460", "WBGene00006868", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q95PX0", "WBGene00006410", "Q19467", "WBGene00008805", "Q03206", "ced-10", "species_29438", "Q21430", "WBGene00010776", "O61460", "WBGene00006868", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q95PX0", "WBGene00006410", "Q19467", "WBGene00008805", "Q17850", "WBGene00003911", "G5EGQ3", "WBGene00003144" ] }, "reaction_10548765": { "compartment": "compartment_70101", "id": "reaction_10548765", "reactome": "R-CEL-3928631", "name": "GIT1 binds bPIX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10548685", "species_10512284" ], "products": [ "species_10548718" ], "modifiers": [], "additional_components": [ "O61460", "WBGene00006868", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q95PX0", "WBGene00006410", "Q19467", "WBGene00008805", "WBGene00010776", "Q21430", "WBGene00010776", "O61460", "WBGene00006868", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q95PX0", "WBGene00006410", "Q19467", "WBGene00008805" ] }, "reaction_10548687": { "compartment": "compartment_70101", "id": "reaction_10548687", "reactome": "R-CEL-3928614", "name": "EFNB:GRB4 binds GIT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10548683", "species_10548677" ], "products": [ "species_10548685" ], "modifiers": [], "additional_components": [ "WBGene00008805", "O61460", "WBGene00006868", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q95PX0", "WBGene00006410", "O61460", "WBGene00006868", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q95PX0", "WBGene00006410", "Q19467", "WBGene00008805" ] }, "reaction_10548716": { "compartment": "compartment_876", "id": "reaction_10548716", "reactome": "R-CEL-3928624", "name": "EPHBs bind EFNBs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10548493", "species_10548491" ], "products": [ "species_10548503" ], "modifiers": [], "additional_components": [ "WBGene00006868", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "O61460", "WBGene00006868" ] }, "reaction_10548796": { "compartment": "compartment_876", "id": "reaction_10548796", "reactome": "R-CEL-3928651", "name": "NGEF exchanges GTP for GDP on RHOA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10509486" ], "products": [ "species_29420", "species_10509488" ], "modifiers": [ [ "species_10548793", "catalyst" ] ], "additional_components": [ "Q22038", "WBGene00004357", "species_29420", "Q22038", "WBGene00004357", "species_29438", "Q965J0", "WBGene00019487", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "O61460", "WBGene00006868", "Q9N3S5", "WBGene00021635", "G5EE56", "WBGene00005077" ] }, "reaction_10573063": { "compartment": "compartment_7660", "id": "reaction_10573063", "reactome": "R-CEL-9671145", "name": "DKC1 binds SHQ1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10510127", "species_10573059" ], "products": [ "species_10573061" ], "modifiers": [], "additional_components": [ "WBGene00010478", "WBGene00021655", "Q9TYM6", "WBGene00021655", "O17919", "WBGene00010478" ] }, "reaction_10528993": { "compartment": "compartment_17963", "id": "reaction_10528993", "reactome": "R-CEL-914012", "name": "GCNTs transfer GlcNAc from UDP-GlcNAc to Core 1 mucins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_914003", "species_10528918" ], "products": [ "species_10528926", "species_205687" ], "modifiers": [ [ "species_10528990", "catalyst" ] ], "additional_components": [ "Q9U2D6", "WBGene00012901", "P34501", "WBGene00010540", "Q9U2D6", "WBGene00012901", "P34501", "WBGene00010540", "G5EEZ8", "WBGene00001640", "G5EBK7", "WBGene00001644", "O02315", "WBGene00001642", "G5ECK8", "WBGene00001626", "Q19730", "WBGene00001643", "G5EDP7", "WBGene00001641" ] }, "reaction_10528675": { "compartment": "compartment_17963", "id": "reaction_10528675", "reactome": "R-CEL-914006", "name": "Addition of galactose to the Tn antigen via an alpha-1,3 linkage forms a Core 8 glycoprotein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10528570", "species_735682" ], "products": [ "species_205687", "species_10528673" ], "modifiers": [], "additional_components": [ "Q9U2D6", "WBGene00012901", "P34501", "WBGene00010540", "Q9U2D6", "WBGene00012901", "P34501", "WBGene00010540" ] }, "reaction_10529014": { "compartment": "compartment_20699", "id": "reaction_10529014", "reactome": "R-CEL-914018", "name": "Addition of GlcNAc to Core 3 forms a Core 4 glycoprotein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_914003", "species_10528693" ], "products": [ "species_205687", "species_10529011" ], "modifiers": [ [ "species_10528960", "catalyst" ] ], "additional_components": [ "Q9U2D6", "WBGene00012901", "P34501", "WBGene00010540", "P34501", "WBGene00010540", "Q9U2D6", "WBGene00012901", "WBGene00001640" ] }, "reaction_10538297": { "compartment": "compartment_20699", "id": "reaction_10538297", "reactome": "R-CEL-1964505", "name": "C1GALT1 transfers Galactose to the Tn antigen forming Core 1 glycoproteins (T antigens)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10528570", "species_735682" ], "products": [ "species_10528918", "species_205687" ], "modifiers": [ [ "species_10538294", "catalyst" ] ], "additional_components": [ "Q9U2D6", "WBGene00012901", "P34501", "WBGene00010540", "Q9U2D6", "WBGene00012901", "P34501", "WBGene00010540", "Q18515", "WBGene00021403", "O44563", "WBGene00044620", "O17053", "WBGene00021403", "Q22900", "WBGene00021403", "O45579", "WBGene00021403", "O17747", "WBGene00021403", "G5ECT3", "WBGene00021403", "P41881", "WBGene00021403", "O18184", "WBGene00021403", "O16535", "WBGene00021403" ] }, "reaction_10528665": { "compartment": "compartment_17963", "id": "reaction_10528665", "reactome": "R-CEL-914005", "name": "Addition of GlcNAc to the Tn antigen via an alpha-1,3 linkage forms a Core 5 glycoprotein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_914003", "species_10528570" ], "products": [ "species_10528663", "species_205687" ], "modifiers": [], "additional_components": [ "Q9U2D6", "WBGene00012901", "P34501", "WBGene00010540", "Q9U2D6", "WBGene00012901", "P34501", "WBGene00010540" ] }, "reaction_10529003": { "compartment": "compartment_17963", "id": "reaction_10529003", "reactome": "R-CEL-914017", "name": "Addition of GalNAc to the Tn antigen via an alpha-1,6 linkage forms a Core 7 glycoprotein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_735700", "species_10528570" ], "products": [ "species_10529001", "species_205687" ], "modifiers": [], "additional_components": [ "Q9U2D6", "WBGene00012901", "P34501", "WBGene00010540", "Q9U2D6", "WBGene00012901", "P34501", "WBGene00010540" ] }, "reaction_10528685": { "compartment": "compartment_17963", "id": "reaction_10528685", "reactome": "R-CEL-914008", "name": "Addition of GlcNAc to the Tn antigen via a beta-1,6 linkage forms a Core 6 glycoprotein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_914003", "species_10528570" ], "products": [ "species_10528683", "species_205687" ], "modifiers": [], "additional_components": [ "Q9U2D6", "WBGene00012901", "P34501", "WBGene00010540", "Q9U2D6", "WBGene00012901", "P34501", "WBGene00010540" ] }, "reaction_10528910": { "compartment": "compartment_20699", "id": "reaction_10528910", "reactome": "R-CEL-914010", "name": "Addition of GlcNAc to the Tn antigen forms a Core 3 glycoprotein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_914003", "species_10528570" ], "products": [ "species_10528693", "species_205687" ], "modifiers": [ [ "species_10528907", "catalyst" ] ], "additional_components": [ "Q9U2D6", "WBGene00012901", "P34501", "WBGene00010540", "Q9U2D6", "WBGene00012901", "P34501", "WBGene00010540", "Q9XU74", "WBGene00011780", "O62163", "WBGene00011780", "H2L0F4", "WBGene00044618", "O62165", "WBGene00011780", "O02231", "WBGene00011780", "O62375", "WBGene00011780", "O02310", "WBGene00011780", "Q20575", "WBGene00011780", "O17750", "WBGene00011780", "Q6QMT2", "WBGene00000267", "O62114", "WBGene00011780", "G5ECA6", "WBGene00011780", "Q8MQG4", "WBGene00011780", "O62115", "WBGene00011780", "G5EDB3", "WBGene00044630" ] }, "reaction_10528639": { "compartment": "compartment_20699", "id": "reaction_10528639", "reactome": "R-CEL-913675", "name": "GALNTs transfer GalNAc from UDP-GalNAc to mucins to form Tn antigens", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_735700", "species_10528562" ], "products": [ "species_10528570", "species_205687" ], "modifiers": [ [ "species_10528636", "catalyst" ] ], "additional_components": [ "P34501", "WBGene00010540", "Q9U2D6", "WBGene00012901", "Q9U2D6", "WBGene00012901", "P34501", "WBGene00010540", "O61397", "WBGene00001632", "Q95ZJ1", "WBGene00001630", "O61394", "WBGene00001631", "P34678", "WBGene00001628", "Q7K755", "WBGene00001636", "Q8I136", "WBGene00001629", "Q9U2C4", "WBGene00012934" ] }, "reaction_10550347": { "compartment": "compartment_12045", "id": "reaction_10550347", "reactome": "R-CEL-5173192", "name": "POFUT2 transfers fucose to TSR domain-containing proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10550339" ], "products": [ "species_10550147" ], "modifiers": [ [ "species_10550344", "catalyst" ] ], "additional_components": [ "Q19305", "WBGene00006893", "Q966Q0", "WBGene00017376", "Q19349", "WBGene00017376", "G5ECS8", "WBGene00000082", "Q19791", "WBGene00001650", "O76840", "WBGene00003242", "G5ECS8", "WBGene00000082", "Q19791", "WBGene00001650", "Q19349", "WBGene00017376", "Q966Q0", "WBGene00017376", "Q19305", "WBGene00006893", "O76840", "WBGene00003242", "WBGene00010757" ] }, "reaction_10550251": { "compartment": "compartment_12045", "id": "reaction_10550251", "reactome": "R-CEL-5173005", "name": "B3GALTL transfers glucose to O-fucosyl-proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_173594", "species_10550147" ], "products": [ "species_158602", "species_10550243" ], "modifiers": [ [ "species_10550248", "catalyst" ] ], "additional_components": [ "G5ECS8", "WBGene00000082", "Q19791", "WBGene00001650", "Q19349", "WBGene00017376", "Q966Q0", "WBGene00017376", "Q19305", "WBGene00006893", "O76840", "WBGene00003242", "Q19349", "WBGene00017376", "Q966Q0", "WBGene00017376", "G5ECS8", "WBGene00000082", "Q19791", "WBGene00001650", "Q19305", "WBGene00006893", "O76840", "WBGene00003242", "WBGene00022576" ] }, "reaction_10532278": { "compartment": "compartment_70101", "id": "reaction_10532278", "reactome": "R-CEL-1236970", "name": "Proteasomal clevage of exogenous antigen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1236719" ], "products": [ "species_8942986", "species_983036" ], "modifiers": [ [ "species_10502572", "catalyst" ] ], "additional_components": [ "P91477", "WBGene00003950", "Q95PZ7", "WBGene00013435", "Q18115", "WBGene00004459", "O62102", "WBGene00003948", "O17071", "WBGene00004504", "Q10920", "WBGene00016623", "P34286", "WBGene00003952", "Q9XTT9", "WBGene00004506", "Q23449", "WBGene00004468", "Q95005", "WBGene00003925", "P46502", "WBGene00004503", "O61792", "WBGene00004464", "O17586", "WBGene00003922", "O76371", "WBGene00004505", "Q20585", "WBGene00004463", "Q95008", "WBGene00003926", "Q18787", "WBGene00004501", "Q20058", "WBGene00009445", "Q9N599", "WBGene00003924", "O16368", "WBGene00004502", "O61742", "WBGene00004466", "Q09583", "WBGene00003928", "Q966I8", "WBGene00003947", "Q04908", "WBGene00004460", "Q9XUV0", "WBGene00003951", "Q27488", "WBGene00003923", "Q9GZH5", "WBGene00004458", "O44156", "WBGene00003927", "Q22253", "WBGene00004465", "O76577", "WBGene00004467", "P90868", "WBGene00003953", "Q19324", "WBGene00004461", "Q17971", "WBGene00007588", "Q23237", "WBGene00003949", "Q20938", "WBGene00004462" ] }, "reaction_10534835": { "compartment": "compartment_12045", "id": "reaction_10534835", "reactome": "R-CEL-1482647", "name": "2-MAG and DAG are transacylated to TAG by PNPLA2/3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1498728", "species_1500596" ], "products": [ "species_76116", "species_1500594" ], "modifiers": [ [ "species_10534832", "catalyst" ] ], "additional_components": [ "Q11186", "WBGene00015484", "Q18948", "WBGene00015241", "Q9N5Z7", "WBGene00015241" ] }, "reaction_10534837": { "compartment": "compartment_12045", "id": "reaction_10534837", "reactome": "R-CEL-1482654", "name": "2-MAG is transacylated to DAG by PNPLA2/3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1498728" ], "products": [ "species_76116", "species_1500596" ], "modifiers": [ [ "species_10534832", "catalyst" ] ], "additional_components": [ "Q11186", "WBGene00015484", "Q18948", "WBGene00015241", "Q9N5Z7", "WBGene00015241" ] }, "reaction_10534887": { "compartment": "compartment_12045", "id": "reaction_10534887", "reactome": "R-CEL-1482811", "name": "DAG is hydrolyzed to 2-MAG by PNPLA2/3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1500596" ], "products": [ "species_1498728", "species_1524021" ], "modifiers": [ [ "species_10534832", "catalyst" ] ], "additional_components": [ "Q11186", "WBGene00015484", "Q18948", "WBGene00015241", "Q9N5Z7", "WBGene00015241" ] }, "reaction_10534873": { "compartment": "compartment_12045", "id": "reaction_10534873", "reactome": "R-CEL-1482777", "name": "TAG is hydrolyzed to DAG by PNPLA2/3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1500594" ], "products": [ "species_1524021", "species_1500596" ], "modifiers": [ [ "species_10534832", "catalyst" ] ], "additional_components": [ "Q11186", "WBGene00015484", "Q18948", "WBGene00015241", "Q9N5Z7", "WBGene00015241" ] }, "reaction_10534923": { "compartment": "compartment_12045", "id": "reaction_10534923", "reactome": "R-CEL-1482889", "name": "DAG is acylated to TAG by DGAT1/2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500578", "species_1500596" ], "products": [ "species_1500594", "species_76194" ], "modifiers": [ [ "species_10534920", "catalyst" ] ], "additional_components": [ "Q9NCE1", "WBGene00010408", "Q9XUW0", "WBGene00010296", "O01881", "WBGene00021818", "Q23067", "WBGene00020910", "Q9N4S3", "WBGene00021818" ] }, "reaction_10557644": { "compartment": "compartment_12045", "id": "reaction_10557644", "reactome": "R-CEL-5696448", "name": "AWAT2 transfers acyl group from acyl-CoA to MAG, forming DAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5696449", "species_6782195" ], "products": [ "species_76194", "species_1500596" ], "modifiers": [ [ "species_10557641", "catalyst" ] ], "additional_components": [ "O01881", "WBGene00021818", "Q23067", "WBGene00020910", "Q9N4S3", "WBGene00021818", "Q9XUW0", "WBGene00010296" ] }, "reaction_10564718": { "compartment": "compartment_12045", "id": "reaction_10564718", "reactome": "R-CEL-8848580", "name": "DGAT2L6,L7P transfer acyl group from acyl-CoA to DAG, forming TAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500578", "species_1500596" ], "products": [ "species_1500594", "species_76194" ], "modifiers": [ [ "species_10564715", "catalyst" ] ], "additional_components": [ "O01881", "WBGene00021818", "Q23067", "WBGene00020910", "Q9N4S3", "WBGene00021818", "Q9XUW0", "WBGene00010296" ] }, "reaction_10517713": { "compartment": "compartment_70101", "id": "reaction_10517713", "reactome": "R-CEL-265295", "name": "Prostaglandin E synthase isomerizes PGH2 to PGE2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_265283" ], "products": [ "species_265287" ], "modifiers": [ [ "species_10517710", "catalyst" ] ], "additional_components": [ "Q21925", "WBGene00011239", "Q23280", "WBGene00022599" ] }, "reaction_10542977": { "compartment": "compartment_70101", "id": "reaction_10542977", "reactome": "R-CEL-2161614", "name": "PGD2 is reduced to 11-epi-PGF2a by AKRIC3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_879629" ], "products": [ "species_29366", "species_2142710" ], "modifiers": [ [ "species_10513233", "catalyst" ] ], "additional_components": [ "P91020", "WBGene00016985", "Q18903", "WBGene00016985", "Q23320", "WBGene00016985" ] }, "reaction_10542982": { "compartment": "compartment_70101", "id": "reaction_10542982", "reactome": "R-CEL-2161701", "name": "PGH2 is isomerised to PGD2 by HPGDS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_265283" ], "products": [ "species_879629" ], "modifiers": [ [ "species_10542979", "catalyst" ] ], "additional_components": [ "Q09607", "WBGene00001784", "species_1655887" ] }, "reaction_10542974": { "compartment": "compartment_70101", "id": "reaction_10542974", "reactome": "R-CEL-2161549", "name": "PGH2 is reduced to PGF2a by AKR1C3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_265283", "species_29364" ], "products": [ "species_29366", "species_879535" ], "modifiers": [ [ "species_10513233", "catalyst" ] ], "additional_components": [ "P91020", "WBGene00016985", "Q18903", "WBGene00016985", "Q23320", "WBGene00016985" ] }, "reaction_10569857": { "compartment": "compartment_70616", "id": "reaction_10569857", "reactome": "R-CEL-8953461", "name": "SMDT1 assists in assembling MCU, MCUB, MICU1, MICU2 (or MICU3) yielding the MCU complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10568878", "species_10568873", "species_10568887", "species_10568868", "species_10568866" ], "products": [ "species_10568889" ], "modifiers": [], "additional_components": [ "WBGene00008980", "WBGene00013462", "Q18874", "WBGene00008345", "WBGene00019296", "WBGene00019296", "Q21121", "WBGene00019296", "Q18874", "WBGene00008345", "Q95PZ2", "WBGene00013462", "Q9U3I4", "WBGene00008980" ] }, "reaction_10568954": { "compartment": "compartment_70616", "id": "reaction_10568954", "reactome": "R-CEL-8949649", "name": "PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10568937" ], "products": [ "species_10568878", "species_10568939", "species_10568933" ], "modifiers": [ [ "species_10568951", "catalyst" ] ], "additional_components": [ "P54813", "WBGene00010842", "Q9N3T5", "WBGene00004978", "species_216785", "Q9BKU4", "WBGene00004014", "P50093", "WBGene00004015", "Q2HQK3", "WBGene00044745", "G5EDB6", "WBGene00021425", "Q9U3I4", "WBGene00008980", "WBGene00008980", "WBGene00008980", "P54813", "WBGene00010842", "Q9N3T5", "WBGene00004978", "species_216785", "Q9BKU4", "WBGene00004014", "P50093", "WBGene00004015", "Q2HQK3", "WBGene00044745", "G5EDB6", "WBGene00021425", "Q95XN2", "WBGene00022159", "Q23295", "WBGene00013880" ] }, "reaction_10568957": { "compartment": "compartment_70616", "id": "reaction_10568957", "reactome": "R-CEL-8949659", "name": "AFG3L2 (m-AAA protease) degrades SMDT1 that is not assembled in MCU", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10568878" ], "products": [], "modifiers": [ [ "species_10568933", "catalyst" ] ], "additional_components": [ "WBGene00008980", "P54813", "WBGene00010842", "Q9N3T5", "WBGene00004978", "species_216785", "Q9BKU4", "WBGene00004014", "P50093", "WBGene00004015", "Q2HQK3", "WBGene00044745", "G5EDB6", "WBGene00021425" ] }, "reaction_10568959": { "compartment": "compartment_70616", "id": "reaction_10568959", "reactome": "R-CEL-8949661", "name": "C2orf47:AFG3L2 binds the transit peptide of SMDT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10568935", "species_10568933" ], "products": [ "species_10568937" ], "modifiers": [], "additional_components": [ "WBGene00008980", "P54813", "WBGene00010842", "Q9N3T5", "WBGene00004978", "species_216785", "Q9BKU4", "WBGene00004014", "P50093", "WBGene00004015", "Q2HQK3", "WBGene00044745", "G5EDB6", "WBGene00021425", "P54813", "WBGene00010842", "Q9N3T5", "WBGene00004978", "species_216785", "Q9BKU4", "WBGene00004014", "P50093", "WBGene00004015", "Q2HQK3", "WBGene00044745", "G5EDB6", "WBGene00021425", "Q9U3I4", "WBGene00008980" ] }, "reaction_10568964": { "compartment": "compartment_70616", "id": "reaction_10568964", "reactome": "R-CEL-8949688", "name": "SLC8B1 (NCLX) exchanges sodium (mitochondrial intermembrane space) for calcium (mitochondrial matrix)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2889072", "species_8949220" ], "products": [ "species_8949232", "species_2889083" ], "modifiers": [ [ "species_10568961", "catalyst" ] ], "additional_components": [ "WBGene00003572" ] }, "reaction_10568892": { "compartment": "compartment_70616", "id": "reaction_10568892", "reactome": "R-CEL-8949178", "name": "MCU translocates calcium from the mitochondrial intermembrane space to the mitochondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8949232" ], "products": [ "species_8949220" ], "modifiers": [ [ "species_10568889", "catalyst" ] ], "additional_components": [ "Q21121", "WBGene00019296", "Q18874", "WBGene00008345", "Q95PZ2", "WBGene00013462", "Q9U3I4", "WBGene00008980" ] }, "reaction_10505728": { "compartment": "compartment_70101", "id": "reaction_10505728", "reactome": "R-CEL-72670", "name": "Formation of eIF2:GDP:eIF2B intermediate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10505724", "species_10505685" ], "products": [ "species_10505726" ], "modifiers": [], "additional_components": [ "G5EFF9", "WBGene00008670", "Q18994", "WBGene00008428", "P34604", "WBGene00014221", "P80361", "WBGene00004090", "Q9XWD5", "WBGene00012950", "species_29420", "Q9BKU3", "WBGene00021351", "Q21230", "WBGene00010560", "Q95XR0", "WBGene00021466", "species_29420", "G5EFF9", "WBGene00008670", "Q18994", "WBGene00008428", "P34604", "WBGene00014221", "P80361", "WBGene00004090", "Q9XWD5", "WBGene00012950", "Q9BKU3", "WBGene00021351", "Q21230", "WBGene00010560", "Q95XR0", "WBGene00021466" ] }, "reaction_10506002": { "compartment": "compartment_70101", "id": "reaction_10506002", "reactome": "R-CEL-72722", "name": "eIF2 activation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10505726" ], "products": [ "species_10505724", "species_29420", "species_10505633" ], "modifiers": [ [ "species_10505724", "catalyst" ] ], "additional_components": [ "species_29420", "G5EFF9", "WBGene00008670", "Q18994", "WBGene00008428", "P34604", "WBGene00014221", "P80361", "WBGene00004090", "Q9XWD5", "WBGene00012950", "Q9BKU3", "WBGene00021351", "Q21230", "WBGene00010560", "Q95XR0", "WBGene00021466", "G5EFF9", "WBGene00008670", "Q18994", "WBGene00008428", "P34604", "WBGene00014221", "P80361", "WBGene00004090", "Q9XWD5", "WBGene00012950", "species_29438", "Q9BKU3", "WBGene00021351", "Q21230", "WBGene00010560", "Q95XR0", "WBGene00021466", "G5EFF9", "WBGene00008670", "Q18994", "WBGene00008428", "P34604", "WBGene00014221", "P80361", "WBGene00004090", "Q9XWD5", "WBGene00012950" ] }, "reaction_10508240": { "compartment": "compartment_5460", "id": "reaction_10508240", "reactome": "R-CEL-77312", "name": "(S)-Hydroxybutanoyl-CoA+NAD<=>Acetoacetyl-CoA+NADH+H", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113526", "species_77251" ], "products": [ "species_73871", "species_113529", "species_29362" ], "modifiers": [ [ "species_10508194", "catalyst" ] ], "additional_components": [ "P41938", "WBGene00007129" ] }, "reaction_10508242": { "compartment": "compartment_5460", "id": "reaction_10508242", "reactome": "R-CEL-77314", "name": "Crotonoyl-CoA+H2O<=>(S)-3-Hydroxybutanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77313", "species_113521" ], "products": [ "species_77251" ], "modifiers": [ [ "species_10503463", "catalyst" ] ], "additional_components": [ "P34559", "WBGene00001155" ] }, "reaction_10552459": { "compartment": "compartment_876", "id": "reaction_10552459", "reactome": "R-CEL-5577234", "name": "KCND tetramer:KCNIP tetramer transport K+ from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10552456", "catalyst" ] ], "additional_components": [ "Q95XD1", "WBGene00022240", "O45313", "WBGene00008307", "A0A4V0IK35", "WBGene00015867", "G5EGM2", "WBGene00008998", "O16638", "WBGene00021116" ] }, "reaction_10571473": { "compartment": "compartment_70101", "id": "reaction_10571473", "reactome": "R-CEL-9018862", "name": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_9022655" ], "products": [ "species_9022660" ], "modifiers": [ [ "species_10517863", "catalyst" ] ], "additional_components": [ "species_216785", "G5EFT4", "WBGene00016589" ] }, "reaction_10571478": { "compartment": "compartment_70101", "id": "reaction_10571478", "reactome": "R-CEL-9018868", "name": "GPX4-2 reduces 18(S)-HpEPE to 18(S)-HEPE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9020583", "species_29450" ], "products": [ "species_29356", "species_9020474", "species_111745" ], "modifiers": [ [ "species_10571475", "catalyst" ] ], "additional_components": [ "WBGene00019846" ] }, "reaction_10521687": { "compartment": "compartment_876", "id": "reaction_10521687", "reactome": "R-CEL-416690", "name": "SEMA4A binds to PLXND1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10521671", "species_10521683" ], "products": [ "species_10521685" ], "modifiers": [], "additional_components": [ "O45657", "WBGene00004048", "U4PRY7", "WBGene00004047", "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "Q95XP4", "WBGene00003111", "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "Q95XP4", "WBGene00003111", "O45657", "WBGene00004048", "U4PRY7", "WBGene00004047" ] }, "reaction_10521675": { "compartment": "compartment_984", "id": "reaction_10521675", "reactome": "R-CEL-416683", "name": "SEMA3E binds to PLXND1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10521671", "species_10521665" ], "products": [ "species_10521673" ], "modifiers": [], "additional_components": [ "O45657", "WBGene00004048", "U4PRY7", "WBGene00004047", "Q17330", "WBGene00004889", "Q95XP4", "WBGene00003111", "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "Q95XP4", "WBGene00003111", "Q9TYS4", "WBGene00004890", "O45657", "WBGene00004048", "U4PRY7", "WBGene00004047" ] }, "reaction_10524174": { "compartment": "compartment_876", "id": "reaction_10524174", "reactome": "R-CEL-434989", "name": "SEMA7A binds to PLXNC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10524170", "species_10524162" ], "products": [ "species_10524172" ], "modifiers": [], "additional_components": [ "Q17330", "WBGene00004889", "Q95XP4", "WBGene00003111", "Q9TYS4", "WBGene00004890", "U4PRY7", "WBGene00004047", "O45657", "WBGene00004048", "U4PRY7", "WBGene00004047", "O45657", "WBGene00004048", "Q17330", "WBGene00004889", "Q95XP4", "WBGene00003111", "Q9TYS4", "WBGene00004890" ] }, "reaction_10508448": { "compartment": "compartment_7660", "id": "reaction_10508448", "reactome": "R-CEL-109638", "name": "Recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10507139", "species_10504433" ], "products": [ "species_10507141" ], "modifiers": [], "additional_components": [ "Q95ZS0", "WBGene00006392", "Q9GZI6", "WBGene00006387", "G5EF68", "WBGene00006386", "O45784", "WBGene00006391", "P32085", "WBGene00006542", "O61707", "WBGene00006385", "Q9NEW8", "WBGene00006389", "Q9TYN3", "WBGene00006383", "Q18265", "WBGene00016173", "Q17957", "WBGene00006397", "E9P861", "WBGene00006384", "Q20361", "WBGene00006395", "G5EGM3", "WBGene00006382", "O44625", "WBGene00004136", "Q9NEX2", "WBGene00013736", "O16991", "WBGene00006648", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q95ZS0", "WBGene00006392", "Q9GZI6", "WBGene00006387", "G5EF68", "WBGene00006386", "O45784", "WBGene00006391", "P32085", "WBGene00006542", "O61707", "WBGene00006385", "Q9NEW8", "WBGene00006389", "Q9TYN3", "WBGene00006383", "Q18265", "WBGene00016173", "Q17957", "WBGene00006397", "E9P861", "WBGene00006384", "Q20361", "WBGene00006395", "G5EGM3", "WBGene00006382", "O44625", "WBGene00004136", "Q9NEX2", "WBGene00013736", "O16991", "WBGene00006648" ] }, "reaction_10508450": { "compartment": "compartment_7660", "id": "reaction_10508450", "reactome": "R-CEL-109639", "name": "Formation of the closed pre-initiation complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10506316", "species_10507143" ], "products": [ "species_10507432" ], "modifiers": [], "additional_components": [ "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "G5EG49", "WBGene00013998", "G5EG47", "WBGene00010054", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q95ZS0", "WBGene00006392", "Q9GZI6", "WBGene00006387", "G5EF68", "WBGene00006386", "O45784", "WBGene00006391", "P32085", "WBGene00006542", "O61707", "WBGene00006385", "Q9NEW8", "WBGene00006389", "Q9TYN3", "WBGene00006383", "Q18265", "WBGene00016173", "Q17957", "WBGene00006397", "E9P861", "WBGene00006384", "Q20361", "WBGene00006395", "G5EGM3", "WBGene00006382", "O44625", "WBGene00004136", "Q9NEX2", "WBGene00013736", "O16991", "WBGene00006648", "G5EG49", "WBGene00013998", "G5EG47", "WBGene00010054", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q95ZS0", "WBGene00006392", "Q9GZI6", "WBGene00006387", "G5EF68", "WBGene00006386", "O45784", "WBGene00006391", "P32085", "WBGene00006542", "O61707", "WBGene00006385", "Q9NEW8", "WBGene00006389", "Q9TYN3", "WBGene00006383", "Q18265", "WBGene00016173", "Q17957", "WBGene00006397", "E9P861", "WBGene00006384", "Q20361", "WBGene00006395", "G5EGM3", "WBGene00006382", "O44625", "WBGene00004136", "Q9NEX2", "WBGene00013736", "O16991", "WBGene00006648", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529" ] }, "reaction_10507145": { "compartment": "compartment_7660", "id": "reaction_10507145", "reactome": "R-CEL-75095", "name": "Binding of TFIIE to the growing preinitiation complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10507141", "species_10506528" ], "products": [ "species_10507143" ], "modifiers": [], "additional_components": [ "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q95ZS0", "WBGene00006392", "Q9GZI6", "WBGene00006387", "G5EF68", "WBGene00006386", "O45784", "WBGene00006391", "P32085", "WBGene00006542", "O61707", "WBGene00006385", "Q9NEW8", "WBGene00006389", "Q9TYN3", "WBGene00006383", "Q18265", "WBGene00016173", "Q17957", "WBGene00006397", "E9P861", "WBGene00006384", "Q20361", "WBGene00006395", "G5EGM3", "WBGene00006382", "O44625", "WBGene00004136", "Q9NEX2", "WBGene00013736", "O16991", "WBGene00006648", "G5EG49", "WBGene00013998", "G5EG47", "WBGene00010054", "G5EG49", "WBGene00013998", "G5EG47", "WBGene00010054", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q95ZS0", "WBGene00006392", "Q9GZI6", "WBGene00006387", "G5EF68", "WBGene00006386", "O45784", "WBGene00006391", "P32085", "WBGene00006542", "O61707", "WBGene00006385", "Q9NEW8", "WBGene00006389", "Q9TYN3", "WBGene00006383", "Q18265", "WBGene00016173", "Q17957", "WBGene00006397", "E9P861", "WBGene00006384", "Q20361", "WBGene00006395", "G5EGM3", "WBGene00006382", "O44625", "WBGene00004136", "Q9NEX2", "WBGene00013736", "O16991", "WBGene00006648" ] }, "reaction_10508444": { "compartment": "compartment_7660", "id": "reaction_10508444", "reactome": "R-CEL-109636", "name": "Recognition and Binding of Core Promoter Elements by TFIID", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109627", "species_10506516" ], "products": [ "species_10507137" ], "modifiers": [], "additional_components": [ "Q95ZS0", "WBGene00006392", "Q9GZI6", "WBGene00006387", "G5EF68", "WBGene00006386", "O45784", "WBGene00006391", "P32085", "WBGene00006542", "O61707", "WBGene00006385", "Q9NEW8", "WBGene00006389", "Q9TYN3", "WBGene00006383", "Q18265", "WBGene00016173", "Q17957", "WBGene00006397", "E9P861", "WBGene00006384", "Q20361", "WBGene00006395", "G5EGM3", "WBGene00006382", "Q95ZS0", "WBGene00006392", "Q9GZI6", "WBGene00006387", "G5EF68", "WBGene00006386", "O45784", "WBGene00006391", "P32085", "WBGene00006542", "O61707", "WBGene00006385", "Q9NEW8", "WBGene00006389", "Q9TYN3", "WBGene00006383", "Q18265", "WBGene00016173", "Q17957", "WBGene00006397", "E9P861", "WBGene00006384", "Q20361", "WBGene00006395", "G5EGM3", "WBGene00006382" ] }, "reaction_10508446": { "compartment": "compartment_7660", "id": "reaction_10508446", "reactome": "R-CEL-109637", "name": "Binding of TFIIA and TFIIB to the pol II promoter:TFIID complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10506438", "species_10506433", "species_10507137" ], "products": [ "species_10507139" ], "modifiers": [], "additional_components": [ "WBGene00006648", "O44625", "WBGene00004136", "Q9NEX2", "WBGene00013736", "Q95ZS0", "WBGene00006392", "Q9GZI6", "WBGene00006387", "G5EF68", "WBGene00006386", "O45784", "WBGene00006391", "P32085", "WBGene00006542", "O61707", "WBGene00006385", "Q9NEW8", "WBGene00006389", "Q9TYN3", "WBGene00006383", "Q18265", "WBGene00016173", "Q17957", "WBGene00006397", "E9P861", "WBGene00006384", "Q20361", "WBGene00006395", "G5EGM3", "WBGene00006382", "Q95ZS0", "WBGene00006392", "Q9GZI6", "WBGene00006387", "G5EF68", "WBGene00006386", "O45784", "WBGene00006391", "P32085", "WBGene00006542", "O61707", "WBGene00006385", "Q9NEW8", "WBGene00006389", "Q9TYN3", "WBGene00006383", "Q18265", "WBGene00016173", "Q17957", "WBGene00006397", "E9P861", "WBGene00006384", "Q20361", "WBGene00006395", "G5EGM3", "WBGene00006382", "O44625", "WBGene00004136", "Q9NEX2", "WBGene00013736", "O16991", "WBGene00006648" ] }, "reaction_10532932": { "compartment": "compartment_876", "id": "reaction_10532932", "reactome": "R-CEL-1299359", "name": "Activation of TALK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10532929", "catalyst" ] ], "additional_components": [ "O45891", "WBGene00006692", "G5ED42", "WBGene00006670", "Q65XY3", "WBGene00019904", "Q18261", "WBGene00016168", "G5EEH1", "WBGene00006693", "Q6BES3", "WBGene00006677", "Q19525", "WBGene00006661", "I2HAD3", "WBGene00006676", "Q93732", "WBGene00006681", "C0Z3L1", "WBGene00001190", "Q23435", "WBGene00006664" ] }, "reaction_10532792": { "compartment": "compartment_876", "id": "reaction_10532792", "reactome": "R-CEL-1296348", "name": "Activation of TWIK-related K+ channel (TREK)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10532789", "catalyst" ] ], "additional_components": [ "G5ECW6", "WBGene00006673", "O17185", "WBGene00006318" ] }, "reaction_10532802": { "compartment": "compartment_876", "id": "reaction_10532802", "reactome": "R-CEL-1299297", "name": "Activation of THIK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10532799", "catalyst" ] ], "additional_components": [ "F5GUD1", "WBGene00006669" ] }, "reaction_10532833": { "compartment": "compartment_876", "id": "reaction_10532833", "reactome": "R-CEL-1299304", "name": "Activation of tandem pore domain in a weak inwardly rectifying K+ channels", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10532830", "catalyst" ] ], "additional_components": [ "Q10937", "WBGene00015137", "Q9NEV3", "WBGene00006696" ] }, "reaction_10532854": { "compartment": "compartment_876", "id": "reaction_10532854", "reactome": "R-CEL-1299318", "name": "Activation of TASK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10532851", "catalyst" ] ], "additional_components": [ "G5ECW6", "WBGene00006673", "O17185", "WBGene00006318" ] }, "reaction_10532864": { "compartment": "compartment_876", "id": "reaction_10532864", "reactome": "R-CEL-1299338", "name": "Activation of TRESK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10532861", "catalyst" ] ], "additional_components": [ "Q22043", "WBGene00006675" ] }, "reaction_10532761": { "compartment": "compartment_876", "id": "reaction_10532761", "reactome": "R-CEL-1296046", "name": "KCNJs transport K+ from the extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74126" ], "products": [ "species_29804" ], "modifiers": [ [ "species_10532758", "catalyst" ] ], "additional_components": [ "P52192", "WBGene00002149", "A0A1C3NSK2", "WBGene00002151", "A0A1C3NSN6", "WBGene00002150" ] }, "reaction_10532746": { "compartment": "compartment_876", "id": "reaction_10532746", "reactome": "R-CEL-1296045", "name": "Activation of Potassium transport channels", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10532743", "catalyst" ] ], "additional_components": [ "P52192", "WBGene00002149", "A0A1C3NSK2", "WBGene00002151", "A0A1C3NSN6", "WBGene00002150" ] }, "reaction_10566209": { "compartment": "compartment_7660", "id": "reaction_10566209", "reactome": "R-CEL-8865454", "name": "CBFB binds RUNX3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10566205", "species_10566197" ], "products": [ "species_10566207" ], "modifiers": [], "additional_components": [ "WBGene00004393", "WBGene00000272", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393" ] }, "reaction_10568338": { "compartment": "compartment_70101", "id": "reaction_10568338", "reactome": "R-CEL-8937792", "name": "RUNX3 binds SRC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10568334", "species_10518187" ], "products": [ "species_10568336" ], "modifiers": [], "additional_components": [ "WBGene00004393", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "G5EFQ5", "WBGene00004393" ] }, "reaction_10569702": { "compartment": "compartment_7660", "id": "reaction_10569702", "reactome": "R-CEL-8952399", "name": "Polyubiquitinated RUNX3 translocates to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10569698" ], "products": [ "species_10569700" ], "modifiers": [], "additional_components": [ "WBGene00004393", "WBGene00004393" ] }, "reaction_10568344": { "compartment": "compartment_70101", "id": "reaction_10568344", "reactome": "R-CEL-8937807", "name": "SRC phosphorylates RUNX3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10568336" ], "products": [ "species_10518187", "species_29370", "species_10568341" ], "modifiers": [ [ "species_10568336", "catalyst" ] ], "additional_components": [ "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "G5EFQ5", "WBGene00004393", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "WBGene00004393", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "G5EFQ5", "WBGene00004393" ] }, "reaction_10569704": { "compartment": "compartment_70101", "id": "reaction_10569704", "reactome": "R-CEL-8952408", "name": "Polyubiquitinated RUNX3 is degraded by the proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10569700" ], "products": [ "species_10502375" ], "modifiers": [ [ "species_10512606", "catalyst" ] ], "additional_components": [ "WBGene00004393", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "Q23237", "WBGene00003949", "P90868", "WBGene00003953", "Q9XUV0", "WBGene00003951", "Q966I8", "WBGene00003947", "O62102", "WBGene00003948", "O16368", "WBGene00004502", "Q18787", "WBGene00004501", "O76371", "WBGene00004505", "P46502", "WBGene00004503", "Q9XTT9", "WBGene00004506", "O17071", "WBGene00004504", "Q18115", "WBGene00004459", "Q20938", "WBGene00004462", "Q19324", "WBGene00004461", "Q22253", "WBGene00004465", "Q9GZH5", "WBGene00004458", "Q04908", "WBGene00004460", "O61742", "WBGene00004466", "O76577", "WBGene00004467", "Q20058", "WBGene00009445", "O44156", "WBGene00003927", "Q20585", "WBGene00004463", "Q27488", "WBGene00003923", "O61792", "WBGene00004464", "Q09583", "WBGene00003928", "Q23449", "WBGene00004468", "Q9N599", "WBGene00003924", "Q10920", "WBGene00016623", "Q95008", "WBGene00003926", "Q95PZ7", "WBGene00013435", "O17586", "WBGene00003922", "Q95005", "WBGene00003925", "P34286", "WBGene00003952", "P91477", "WBGene00003950" ] }, "reaction_10568346": { "compartment": "compartment_70101", "id": "reaction_10568346", "reactome": "R-CEL-8937814", "name": "RUNX3 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10568334" ], "products": [ "species_10566205" ], "modifiers": [ [ "species_10511431", "catalyst" ], [ "species_10518187", "inhibitor" ] ], "additional_components": [ "WBGene00004393", "WBGene00004393", "G5EBY8", "WBGene00006852", "G5EEL5", "WBGene00000936", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635" ] }, "reaction_10518768": { "compartment": "compartment_876", "id": "reaction_10518768", "reactome": "R-CEL-374686", "name": "L1 interaction with Integrins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10518718", "species_10518764" ], "products": [ "species_10518766" ], "modifiers": [], "additional_components": [ "Q21465", "WBGene00019727", "Q5WRR1", "WBGene00006942", "P34446", "WBGene00003929", "Q27874", "WBGene00003930", "P34446", "WBGene00003929", "Q27874", "WBGene00003930", "Q21465", "WBGene00019727", "Q5WRR1", "WBGene00006942" ] }, "reaction_10524706": { "compartment": "compartment_70101", "id": "reaction_10524706", "reactome": "R-CEL-445064", "name": "Activation of Rac1 by VAV2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10520575", "species_29438" ], "products": [ "species_29420", "species_10509457" ], "modifiers": [ [ "species_10524306", "catalyst" ] ], "additional_components": [ "species_29420", "Q03206", "ced-10", "species_29438", "Q03206", "ced-10", "WBGene00006887" ] }, "reaction_10524710": { "compartment": "compartment_876", "id": "reaction_10524710", "reactome": "R-CEL-445069", "name": "L1-EGFR trans-heterodimerization", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10518718", "species_10512185" ], "products": [ "species_10524708" ], "modifiers": [], "additional_components": [ "Q21465", "WBGene00019727", "Q5WRR1", "WBGene00006942", "WBGene00002299", "P24348", "WBGene00002299", "Q21465", "WBGene00019727", "Q5WRR1", "WBGene00006942" ] }, "reaction_10521079": { "compartment": "compartment_70101", "id": "reaction_10521079", "reactome": "R-CEL-392752", "name": "Phosphorylation of L1 by CK-II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10518718", "species_10515097", "species_113592" ], "products": [ "species_29370", "species_10521077" ], "modifiers": [ [ "species_10515097", "catalyst" ] ], "additional_components": [ "Q21465", "WBGene00019727", "Q5WRR1", "WBGene00006942", "P18334", "WBGene00002191", "P28548", "WBGene00002196", "Q5WRR1", "WBGene00006942", "Q21465", "WBGene00019727", "P18334", "WBGene00002191", "P28548", "WBGene00002196", "P18334", "WBGene00002191", "P28548", "WBGene00002196" ] }, "reaction_10518762": { "compartment": "compartment_876", "id": "reaction_10518762", "reactome": "R-CEL-374681", "name": "L1 and NCAM1 engaged in cis-interaction", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10518718", "species_10518758" ], "products": [ "species_10518760" ], "modifiers": [], "additional_components": [ "Q21465", "WBGene00019727", "Q5WRR1", "WBGene00006942", "WBGene00004372", "C6KRM7", "WBGene00004372", "Q21465", "WBGene00019727", "Q5WRR1", "WBGene00006942" ] }, "reaction_10524715": { "compartment": "compartment_70101", "id": "reaction_10524715", "reactome": "R-CEL-445072", "name": "Interaction of PAK1 with Rac1-GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10509457", "species_10520672" ], "products": [ "species_10520670", "species_29370", "species_10524712" ], "modifiers": [ [ "species_10520670", "catalyst" ] ], "additional_components": [ "species_29438", "Q03206", "ced-10", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "species_29438", "Q03206", "ced-10", "Q17850", "WBGene00003911", "G5EGQ3", "WBGene00003144", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911" ] }, "reaction_10516546": { "compartment": "compartment_984", "id": "reaction_10516546", "reactome": "R-CEL-210404", "name": "SLC1A1-3,6,7 exchange L-Glu, H+ and 3Na+ for K+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_210382", "species_29804", "species_74113" ], "products": [ "species_74126", "species_29404", "species_70106", "species_83910" ], "modifiers": [ [ "species_10516538", "catalyst" ], [ "species_10516544", "inhibitor" ] ], "additional_components": [ "Q21353", "WBGene00001621", "Q21751", "WBGene00001624", "Q22682", "WBGene00001622", "Q9UAY8", "WBGene00001625", "O18210", "WBGene00001623", "Q10901", "WBGene00001620", "WBGene00017070" ] }, "reaction_10516838": { "compartment": "compartment_70101", "id": "reaction_10516838", "reactome": "R-CEL-210444", "name": "L-Glutamate loading of synaptic vesicle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29404", "species_10516835" ], "products": [ "species_10516719" ], "modifiers": [ [ "species_10516835", "catalyst" ] ], "additional_components": [ "P34644", "WBGene00001135", "Q10046", "WBGene00011556", "G5EEK1", "WBGene00010755", "Q94986", "WBGene00004267", "Q19136", "WBGene00006306", "K8FE10", "WBGene00004922", "Q23056", "WBGene00020861", "O16700", "WBGene00004925", "Q965S5", "WBGene00004923", "P34693", "WBGene00004921", "Q19767", "WBGene00004898", "G5EBK2", "WBGene00014084", "Q94057", "WBGene00044062", "O02495", "WBGene00004897", "Q95XH1", "WBGene00022077", "P34351", "WBGene00004899", "P34644", "WBGene00001135", "Q10046", "WBGene00011556", "G5EEK1", "WBGene00010755", "Q94986", "WBGene00004267", "Q19136", "WBGene00006306", "K8FE10", "WBGene00004922", "Q23056", "WBGene00020861", "O16700", "WBGene00004925", "Q965S5", "WBGene00004923", "P34693", "WBGene00004921", "Q19767", "WBGene00004898", "G5EBK2", "WBGene00014084", "Q94057", "WBGene00044062", "O02495", "WBGene00004897", "Q95XH1", "WBGene00022077", "P34351", "WBGene00004899", "species_113552", "P34644", "WBGene00001135", "Q10046", "WBGene00011556", "G5EEK1", "WBGene00010755", "Q94986", "WBGene00004267", "Q19136", "WBGene00006306", "K8FE10", "WBGene00004922", "Q23056", "WBGene00020861", "O16700", "WBGene00004925", "Q965S5", "WBGene00004923", "P34693", "WBGene00004921", "Q19767", "WBGene00004898", "G5EBK2", "WBGene00014084", "Q94057", "WBGene00044062", "O02495", "WBGene00004897", "Q95XH1", "WBGene00022077", "P34351", "WBGene00004899" ] }, "reaction_10516828": { "compartment": "compartment_984", "id": "reaction_10516828", "reactome": "R-CEL-210430", "name": "Release of L-Glutamate at the synapse", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10516779", "species_74016" ], "products": [ "species_210382", "species_10516825", "species_10516777", "species_10516809", "species_10516744", "species_10516823", "species_10516631", "species_10516791" ], "modifiers": [ [ "species_10516779", "catalyst" ], [ "species_74016", "catalyst" ] ], "additional_components": [ "G5EEN8", "WBGene00006454", "A5PEW5", "WBGene00004364", "P34815", "WBGene00006757", "Q9GUM7", "WBGene00022271", "Q21049", "WBGene00006364", "Q22366", "WBGene00006750", "P27715", "WBGene00006752", "Q9N415", "WBGene00006513", "O16000", "WBGene00006798", "P34644", "WBGene00001135", "Q10046", "WBGene00011556", "G5EEK1", "WBGene00010755", "Q94986", "WBGene00004267", "Q19136", "WBGene00006306", "K8FE10", "WBGene00004922", "Q23056", "WBGene00020861", "O16700", "WBGene00004925", "Q965S5", "WBGene00004923", "P34693", "WBGene00004921", "Q19767", "WBGene00004898", "G5EBK2", "WBGene00014084", "Q94057", "WBGene00044062", "O02495", "WBGene00004897", "Q95XH1", "WBGene00022077", "P34351", "WBGene00004899", "species_113552", "WBGene00004267", "Q21049", "WBGene00006364", "Q22366", "WBGene00006750", "P27715", "WBGene00006752", "Q9N415", "WBGene00006513", "species_74016", "G5EEN8", "WBGene00006454", "A5PEW5", "WBGene00004364", "Q94057", "WBGene00044062", "Q95XH1", "WBGene00022077", "G5EBK2", "WBGene00014084", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q19767", "WBGene00004898", "O16000", "WBGene00006798", "WBGene00022271", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "WBGene00006757", "G5EEK1", "WBGene00010755", "P34644", "WBGene00001135", "Q10046", "WBGene00011556", "G5EEN8", "WBGene00006454", "A5PEW5", "WBGene00004364", "P34815", "WBGene00006757", "Q9GUM7", "WBGene00022271", "Q21049", "WBGene00006364", "Q22366", "WBGene00006750", "P27715", "WBGene00006752", "Q9N415", "WBGene00006513", "O16000", "WBGene00006798", "P34644", "WBGene00001135", "Q10046", "WBGene00011556", "G5EEK1", "WBGene00010755", "Q94986", "WBGene00004267", "Q19136", "WBGene00006306", "K8FE10", "WBGene00004922", "Q23056", "WBGene00020861", "O16700", "WBGene00004925", "Q965S5", "WBGene00004923", "P34693", "WBGene00004921", "Q19767", "WBGene00004898", "G5EBK2", "WBGene00014084", "Q94057", "WBGene00044062", "O02495", "WBGene00004897", "Q95XH1", "WBGene00022077", "P34351", "WBGene00004899", "species_113552" ] }, "reaction_10516782": { "compartment": "compartment_70101", "id": "reaction_10516782", "reactome": "R-CEL-210426", "name": "Glutamate synaptic vesicle docking and priming", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10516719", "species_10516749", "species_10516777", "species_10516744", "species_10516631", "species_10516739" ], "products": [ "species_10516779" ], "modifiers": [ [ "species_10516719", "catalyst" ], [ "species_10516759", "catalyst" ] ], "additional_components": [ "P34644", "WBGene00001135", "Q10046", "WBGene00011556", "G5EEK1", "WBGene00010755", "Q94986", "WBGene00004267", "Q19136", "WBGene00006306", "K8FE10", "WBGene00004922", "Q23056", "WBGene00020861", "O16700", "WBGene00004925", "Q965S5", "WBGene00004923", "P34693", "WBGene00004921", "Q19767", "WBGene00004898", "G5EBK2", "WBGene00014084", "Q94057", "WBGene00044062", "O02495", "WBGene00004897", "Q95XH1", "WBGene00022077", "P34351", "WBGene00004899", "species_113552", "WBGene00006798", "Q21049", "WBGene00006364", "Q22366", "WBGene00006750", "P27715", "WBGene00006752", "Q9N415", "WBGene00006513", "WBGene00022271", "WBGene00006757", "G5EEN8", "WBGene00006454", "A5PEW5", "WBGene00004364", "G5EEN8", "WBGene00006454", "A5PEW5", "WBGene00004364", "P34815", "WBGene00006757", "Q9GUM7", "WBGene00022271", "Q21049", "WBGene00006364", "Q22366", "WBGene00006750", "P27715", "WBGene00006752", "Q9N415", "WBGene00006513", "O16000", "WBGene00006798", "P34644", "WBGene00001135", "Q10046", "WBGene00011556", "G5EEK1", "WBGene00010755", "Q94986", "WBGene00004267", "Q19136", "WBGene00006306", "K8FE10", "WBGene00004922", "Q23056", "WBGene00020861", "O16700", "WBGene00004925", "Q965S5", "WBGene00004923", "P34693", "WBGene00004921", "Q19767", "WBGene00004898", "G5EBK2", "WBGene00014084", "Q94057", "WBGene00044062", "O02495", "WBGene00004897", "Q95XH1", "WBGene00022077", "P34351", "WBGene00004899", "species_113552", "P34644", "WBGene00001135", "Q10046", "WBGene00011556", "G5EEK1", "WBGene00010755", "Q94986", "WBGene00004267", "Q19136", "WBGene00006306", "K8FE10", "WBGene00004922", "Q23056", "WBGene00020861", "O16700", "WBGene00004925", "Q965S5", "WBGene00004923", "P34693", "WBGene00004921", "Q19767", "WBGene00004898", "G5EBK2", "WBGene00014084", "Q94057", "WBGene00044062", "O02495", "WBGene00004897", "Q95XH1", "WBGene00022077", "P34351", "WBGene00004899", "species_113552", "WBGene00006752" ] }, "reaction_10543028": { "compartment": "compartment_5460", "id": "reaction_10543028", "reactome": "R-CEL-2162186", "name": "DeMQ10H2 is methylated to Q10H2 by COQ3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2162265", "species_2162212" ], "products": [ "species_2162252", "species_113529", "species_2162198" ], "modifiers": [ [ "species_10543025", "catalyst" ] ], "additional_components": [ "WBGene00000763" ] }, "reaction_10543036": { "compartment": "compartment_70616", "id": "reaction_10543036", "reactome": "R-CEL-2162192", "name": "PHB and all-E-10PrP2 are combined into DHB by COQ2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2162214", "species_2162213" ], "products": [ "species_2162207", "species_159450" ], "modifiers": [ [ "species_10543033", "catalyst" ] ], "additional_components": [ "WBGene00000762" ] }, "reaction_10543039": { "compartment": "compartment_5460", "id": "reaction_10543039", "reactome": "R-CEL-2162193", "name": "DHDB is methylated to MHDB by COQ3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2162265", "species_2162209" ], "products": [ "species_2162252", "species_113529", "species_2162215" ], "modifiers": [ [ "species_10543025", "catalyst" ] ], "additional_components": [ "WBGene00000763" ] }, "reaction_10518304": { "compartment": "compartment_70101", "id": "reaction_10518304", "reactome": "R-CEL-372505", "name": "Acetylcholine synaptic vesicle docking and priming", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10517503", "species_10516749", "species_10516777", "species_10516744", "species_10516631", "species_10516739" ], "products": [ "species_10518301" ], "modifiers": [ [ "species_10517503", "catalyst" ] ], "additional_components": [ "species_372533", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "P34711", "WBGene00006756", "Q19767", "WBGene00004898", "G5EBK2", "WBGene00014084", "Q94057", "WBGene00044062", "O02495", "WBGene00004897", "Q95XH1", "WBGene00022077", "P34351", "WBGene00004899", "Q94986", "WBGene00004267", "WBGene00006798", "Q21049", "WBGene00006364", "Q22366", "WBGene00006750", "P27715", "WBGene00006752", "Q9N415", "WBGene00006513", "WBGene00022271", "WBGene00006757", "G5EEN8", "WBGene00006454", "A5PEW5", "WBGene00004364", "G5EEN8", "WBGene00006454", "A5PEW5", "WBGene00004364", "P34815", "WBGene00006757", "Q9GUM7", "WBGene00022271", "Q21049", "WBGene00006364", "Q22366", "WBGene00006750", "P27715", "WBGene00006752", "Q9N415", "WBGene00006513", "O16000", "WBGene00006798", "species_372533", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "P34711", "WBGene00006756", "Q19767", "WBGene00004898", "G5EBK2", "WBGene00014084", "Q94057", "WBGene00044062", "O02495", "WBGene00004897", "Q95XH1", "WBGene00022077", "P34351", "WBGene00004899", "Q94986", "WBGene00004267", "species_372533", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "P34711", "WBGene00006756", "Q19767", "WBGene00004898", "G5EBK2", "WBGene00014084", "Q94057", "WBGene00044062", "O02495", "WBGene00004897", "Q95XH1", "WBGene00022077", "P34351", "WBGene00004899", "Q94986", "WBGene00004267" ] }, "reaction_10518401": { "compartment": "compartment_876", "id": "reaction_10518401", "reactome": "R-CEL-372529", "name": "Release of acetylcholine at the synapse", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10518301" ], "products": [ "species_10518398", "species_10516825", "species_10516777", "species_10516744", "species_10516823", "species_10516631", "species_10516807", "species_372533" ], "modifiers": [ [ "species_10518301", "catalyst" ] ], "additional_components": [ "G5EEN8", "WBGene00006454", "A5PEW5", "WBGene00004364", "P34815", "WBGene00006757", "Q9GUM7", "WBGene00022271", "Q21049", "WBGene00006364", "Q22366", "WBGene00006750", "P27715", "WBGene00006752", "Q9N415", "WBGene00006513", "O16000", "WBGene00006798", "species_372533", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "P34711", "WBGene00006756", "Q19767", "WBGene00004898", "G5EBK2", "WBGene00014084", "Q94057", "WBGene00044062", "O02495", "WBGene00004897", "Q95XH1", "WBGene00022077", "P34351", "WBGene00004899", "Q94986", "WBGene00004267", "WBGene00006756", "WBGene00004267", "Q21049", "WBGene00006364", "Q22366", "WBGene00006750", "P27715", "WBGene00006752", "Q9N415", "WBGene00006513", "WBGene00022271", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "WBGene00006757", "G5EEN8", "WBGene00006454", "A5PEW5", "WBGene00004364", "Q94057", "WBGene00044062", "Q95XH1", "WBGene00022077", "G5EBK2", "WBGene00014084", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q19767", "WBGene00004898", "O16000", "WBGene00006798", "G5EEN8", "WBGene00006454", "A5PEW5", "WBGene00004364", "P34815", "WBGene00006757", "Q9GUM7", "WBGene00022271", "Q21049", "WBGene00006364", "Q22366", "WBGene00006750", "P27715", "WBGene00006752", "Q9N415", "WBGene00006513", "O16000", "WBGene00006798", "species_372533", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "P34711", "WBGene00006756", "Q19767", "WBGene00004898", "G5EBK2", "WBGene00014084", "Q94057", "WBGene00044062", "O02495", "WBGene00004897", "Q95XH1", "WBGene00022077", "P34351", "WBGene00004899", "Q94986", "WBGene00004267" ] }, "reaction_10517506": { "compartment": "compartment_70101", "id": "reaction_10517506", "reactome": "R-CEL-264615", "name": "Loading of acetylcholine in synaptic vesicles", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10517501", "species_372511", "species_264643" ], "products": [ "species_10517503", "species_70106" ], "modifiers": [ [ "species_10517483", "catalyst" ] ], "additional_components": [ "P34711", "WBGene00006756", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "Q19767", "WBGene00004898", "G5EBK2", "WBGene00014084", "Q94057", "WBGene00044062", "O02495", "WBGene00004897", "Q95XH1", "WBGene00022077", "P34351", "WBGene00004899", "Q94986", "WBGene00004267", "species_372533", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "P34711", "WBGene00006756", "Q19767", "WBGene00004898", "G5EBK2", "WBGene00014084", "Q94057", "WBGene00044062", "O02495", "WBGene00004897", "Q95XH1", "WBGene00022077", "P34351", "WBGene00004899", "Q94986", "WBGene00004267", "WBGene00006756" ] }, "reaction_10517514": { "compartment": "compartment_70101", "id": "reaction_10517514", "reactome": "R-CEL-264622", "name": "Cho is acetylated to AcCho by CHAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_264618", "species_76183" ], "products": [ "species_264643", "species_76194" ], "modifiers": [ [ "species_10517511", "catalyst" ] ], "additional_components": [ "WBGene00000481" ] }, "reaction_10554130": { "compartment": "compartment_18730", "id": "reaction_10554130", "reactome": "R-CEL-5638004", "name": "RP2 binds ARL3:GTP:UNC119B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10554126", "species_10554121" ], "products": [ "species_10554128" ], "modifiers": [], "additional_components": [ "WBGene00019536", "species_29438", "O45379", "WBGene00000188", "Q10658", "WBGene00006843", "species_29438", "O45379", "WBGene00000188", "Q10658", "WBGene00006843", "Q966I6", "WBGene00019536" ] }, "reaction_10554148": { "compartment": "compartment_18730", "id": "reaction_10554148", "reactome": "R-CEL-5638016", "name": "RP2:ARL3:GDP:UNC119B dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10554134" ], "products": [ "species_10554126", "species_10554119", "species_10554132" ], "modifiers": [], "additional_components": [ "O45379", "WBGene00000188", "species_29420", "Q10658", "WBGene00006843", "Q966I6", "WBGene00019536", "WBGene00019536", "WBGene00006843", "O45379", "WBGene00000188", "species_29420" ] }, "reaction_10554137": { "compartment": "compartment_18730", "id": "reaction_10554137", "reactome": "R-CEL-5638006", "name": "ARL3 hydrolyzes GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10554128" ], "products": [ "species_10554134" ], "modifiers": [ [ "species_10554128", "catalyst" ] ], "additional_components": [ "species_29438", "O45379", "WBGene00000188", "Q10658", "WBGene00006843", "Q966I6", "WBGene00019536", "O45379", "WBGene00000188", "species_29420", "Q10658", "WBGene00006843", "Q966I6", "WBGene00019536", "species_29438", "O45379", "WBGene00000188", "Q10658", "WBGene00006843", "Q966I6", "WBGene00019536" ] }, "reaction_10554140": { "compartment": "compartment_18730", "id": "reaction_10554140", "reactome": "R-CEL-5638007", "name": "RP2 activates the GTPase activity of ARL3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10554128" ], "products": [ "species_10554128" ], "modifiers": [ [ "species_10554126", "catalyst" ] ], "additional_components": [ "species_29438", "O45379", "WBGene00000188", "Q10658", "WBGene00006843", "Q966I6", "WBGene00019536", "species_29438", "O45379", "WBGene00000188", "Q10658", "WBGene00006843", "Q966I6", "WBGene00019536", "WBGene00019536" ] }, "reaction_10553222": { "compartment": "compartment_261122", "id": "reaction_10553222", "reactome": "R-CEL-5623527", "name": "VxPx-containing ciliary membrane proteins are delivered to the ciliary membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10553196" ], "products": [ "species_10553220" ], "modifiers": [], "additional_components": [ "Q03611", "WBGene00006526", "Q7Z205", "WBGene00000563", "Q9N4C1", "WBGene00022295", "A8WI01", "WBGene00000562", "O61827", "WBGene00000487", "G5EEE2", "WBGene00006525", "O01803", "WBGene00004274", "species_29438", "Q95ZS6", "WBGene00018869", "Q20759", "WBGene00010045", "G5EFC1", "WBGene00004272", "Q21137", "WBGene00019317", "Q9XWS2", "WBGene00004753", "Q18406", "WBGene00016376", "Q18286", "WBGene00016188", "P91149", "WBGene00016606", "Q95Q35", "WBGene00013687", "Q20678", "WBGene00018703", "Q22706", "WBGene00004752", "Q19262", "WBGene00017284", "Q03611", "WBGene00006526", "A8WI01", "WBGene00000562", "O61827", "WBGene00000487", "Q7Z205", "WBGene00000563", "Q9N4C1", "WBGene00022295", "G5EEE2", "WBGene00006525" ] }, "reaction_10553129": { "compartment": "compartment_70101", "id": "reaction_10553129", "reactome": "R-CEL-5623508", "name": "GBF1 stimulates nucleotide exchange on ARF4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10553127" ], "products": [ "species_10553068", "species_29420" ], "modifiers": [ [ "species_10517992", "catalyst" ] ], "additional_components": [ "Q94231", "WBGene00000190", "species_29420", "Q94231", "WBGene00000190", "species_29438", "WBGene00007703" ] }, "reaction_10553198": { "compartment": "compartment_13949", "id": "reaction_10553198", "reactome": "R-CEL-5623524", "name": "The exocyst complex binds to RAB3IP in the ciliary targeting complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10553194", "species_10553176" ], "products": [ "species_10553196" ], "modifiers": [], "additional_components": [ "Q9XWS2", "WBGene00004753", "Q18406", "WBGene00016376", "Q18286", "WBGene00016188", "P91149", "WBGene00016606", "Q95Q35", "WBGene00013687", "Q20678", "WBGene00018703", "Q22706", "WBGene00004752", "Q19262", "WBGene00017284", "Q03611", "WBGene00006526", "Q7Z205", "WBGene00000563", "Q9N4C1", "WBGene00022295", "A8WI01", "WBGene00000562", "O61827", "WBGene00000487", "G5EEE2", "WBGene00006525", "O01803", "WBGene00004274", "species_29438", "Q95ZS6", "WBGene00018869", "Q20759", "WBGene00010045", "G5EFC1", "WBGene00004272", "Q21137", "WBGene00019317", "Q03611", "WBGene00006526", "Q7Z205", "WBGene00000563", "Q9N4C1", "WBGene00022295", "A8WI01", "WBGene00000562", "O61827", "WBGene00000487", "G5EEE2", "WBGene00006525", "O01803", "WBGene00004274", "species_29438", "Q95ZS6", "WBGene00018869", "Q20759", "WBGene00010045", "G5EFC1", "WBGene00004272", "Q21137", "WBGene00019317", "Q9XWS2", "WBGene00004753", "Q18406", "WBGene00016376", "Q18286", "WBGene00016188", "P91149", "WBGene00016606", "Q95Q35", "WBGene00013687", "Q20678", "WBGene00018703", "Q22706", "WBGene00004752", "Q19262", "WBGene00017284" ] }, "reaction_10553265": { "compartment": "compartment_70101", "id": "reaction_10553265", "reactome": "R-CEL-5624125", "name": "Formation of the BBSome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10552766", "species_10552796", "species_10552781", "species_10552776", "species_10552791", "species_10552786", "species_10552771", "species_10552801" ], "products": [ "species_10552803" ], "modifiers": [], "additional_components": [ "WBGene00000241", "WBGene00000244", "WBGene00010974", "WBGene00043992", "WBGene00016744", "WBGene00003892", "WBGene00000242", "WBGene00019482", "Q21273", "WBGene00019482", "Q19640", "WBGene00000242", "Q9XW70", "WBGene00003892", "O01514", "WBGene00016744", "Q5CZ52", "WBGene00043992", "Q21626", "WBGene00010974", "Q23049", "WBGene00000244", "Q9NEZ7", "WBGene00000241" ] }, "reaction_10553298": { "compartment": "compartment_876", "id": "reaction_10553298", "reactome": "R-CEL-5624126", "name": "ARL6:GTP and the BBSome bind ciliary cargo", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10553294", "species_10553272", "species_10552803" ], "products": [ "species_10553296" ], "modifiers": [], "additional_components": [ "H9G358", "WBGene00018089", "P34311", "WBGene00018089", "Q09502", "WBGene00008065", "Q20841", "WBGene00018886", "Q23033", "WBGene00020086", "A0A0K3AXD3", "WBGene00011372", "Q9XVQ0", "WBGene00018089", "A0A2C9C3A4", "WBGene00018089", "A0A3B1DQQ4", "WBGene00006864", "Q18510", "WBGene00000193", "species_29438", "Q21273", "WBGene00019482", "Q19640", "WBGene00000242", "Q9XW70", "WBGene00003892", "O01514", "WBGene00016744", "Q5CZ52", "WBGene00043992", "Q21626", "WBGene00010974", "Q23049", "WBGene00000244", "Q9NEZ7", "WBGene00000241", "Q21273", "WBGene00019482", "Q19640", "WBGene00000242", "Q9XW70", "WBGene00003892", "O01514", "WBGene00016744", "Q5CZ52", "WBGene00043992", "Q21626", "WBGene00010974", "Q23049", "WBGene00000244", "Q9NEZ7", "WBGene00000241", "Q18510", "WBGene00000193", "species_29438", "H9G358", "WBGene00018089", "P34311", "WBGene00018089", "Q09502", "WBGene00008065", "Q20841", "WBGene00018886", "Q23033", "WBGene00020086", "A0A0K3AXD3", "WBGene00011372", "Q9XVQ0", "WBGene00018089", "A0A2C9C3A4", "WBGene00018089", "A0A3B1DQQ4", "WBGene00006864" ] }, "reaction_10553354": { "compartment": "compartment_261122", "id": "reaction_10553354", "reactome": "R-CEL-5624127", "name": "ARL6:GTP and the BBSome target cargo to the primary cilium", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10553296" ], "products": [ "species_10553346" ], "modifiers": [ [ "species_10553352", "inhibitor" ] ], "additional_components": [ "Q21273", "WBGene00019482", "Q19640", "WBGene00000242", "Q9XW70", "WBGene00003892", "O01514", "WBGene00016744", "Q5CZ52", "WBGene00043992", "Q21626", "WBGene00010974", "Q23049", "WBGene00000244", "Q9NEZ7", "WBGene00000241", "Q18510", "WBGene00000193", "species_29438", "H9G358", "WBGene00018089", "P34311", "WBGene00018089", "Q09502", "WBGene00008065", "Q20841", "WBGene00018886", "Q23033", "WBGene00020086", "A0A0K3AXD3", "WBGene00011372", "Q9XVQ0", "WBGene00018089", "A0A2C9C3A4", "WBGene00018089", "A0A3B1DQQ4", "WBGene00006864", "species_29438", "Q18510", "WBGene00000193", "Q21273", "WBGene00019482", "Q19640", "WBGene00000242", "Q9XW70", "WBGene00003892", "O01514", "WBGene00016744", "Q5CZ52", "WBGene00043992", "Q21626", "WBGene00010974", "Q23049", "WBGene00000244", "Q9NEZ7", "WBGene00000241", "Q20841", "WBGene00018886", "Q23033", "WBGene00020086", "A0A0K3AXD3", "WBGene00011372", "Q9XVQ0", "WBGene00018089", "A0A2C9C3A4", "WBGene00018089", "A0A3B1DQQ4", "WBGene00006864", "H9G358", "WBGene00018089", "P34311", "WBGene00018089", "Q09502", "WBGene00008065", "Q21273", "WBGene00019482", "Q19640", "WBGene00000242", "Q9XW70", "WBGene00003892", "O01514", "WBGene00016744", "Q5CZ52", "WBGene00043992", "Q21626", "WBGene00010974", "Q23049", "WBGene00000244", "Q9NEZ7", "WBGene00000241" ] }, "reaction_10552812": { "compartment": "compartment_2132649", "id": "reaction_10552812", "reactome": "R-CEL-5617815", "name": "BBSome binds RAB3IP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10552808", "species_10552803" ], "products": [ "species_10552810" ], "modifiers": [], "additional_components": [ "WBGene00010045", "Q21273", "WBGene00019482", "Q19640", "WBGene00000242", "Q9XW70", "WBGene00003892", "O01514", "WBGene00016744", "Q5CZ52", "WBGene00043992", "Q21626", "WBGene00010974", "Q23049", "WBGene00000244", "Q9NEZ7", "WBGene00000241", "Q21273", "WBGene00019482", "Q19640", "WBGene00000242", "Q9XW70", "WBGene00003892", "O01514", "WBGene00016744", "Q5CZ52", "WBGene00043992", "Q21626", "WBGene00010974", "Q23049", "WBGene00000244", "Q9NEZ7", "WBGene00000241", "Q20759", "WBGene00010045" ] }, "reaction_10521804": { "compartment": "compartment_70101", "id": "reaction_10521804", "reactome": "R-CEL-418456", "name": "cGMP is degraded by PDEs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30991" ], "products": [ "species_113578" ], "modifiers": [ [ "species_10521801", "catalyst" ] ], "additional_components": [ "P30645", "WBGene00011146", "P91119", "WBGene00016328", "O18696", "WBGene00011433" ] }, "reaction_10514144": { "compartment": "compartment_70101", "id": "reaction_10514144", "reactome": "R-CEL-198845", "name": "CYB5A:heme reduces Asc.- to AscH-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1497805", "species_10514130" ], "products": [ "species_198816", "species_10514128" ], "modifiers": [ [ "species_10514130", "catalyst" ] ], "additional_components": [ "species_71185", "O01816", "WBGene00020931", "Q93315", "WBGene00007848", "CHEBI:36144", "O01816", "WBGene00020931", "Q93315", "WBGene00007848", "species_71185", "O01816", "WBGene00020931", "Q93315", "WBGene00007848" ] }, "reaction_10514114": { "compartment": "compartment_876", "id": "reaction_10514114", "reactome": "R-CEL-198818", "name": "SLC2A1,3 transports DeHA from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_198852" ], "products": [ "species_198827" ], "modifiers": [ [ "species_10514111", "catalyst" ] ], "additional_components": [ "Q21381", "WBGene00043980", "Q9GYQ1", "WBGene00043980", "Q21382", "WBGene00043980", "Q9NEI8", "WBGene00043980", "Q21385", "WBGene00043980", "Q5WRR9", "WBGene00043980" ] }, "reaction_10514195": { "compartment": "compartment_876", "id": "reaction_10514195", "reactome": "R-CEL-198870", "name": "SLC23A1,2 cotransports AscH-, 2Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_198836", "species_74113" ], "products": [ "species_83910", "species_198816" ], "modifiers": [ [ "species_10514192", "catalyst" ] ], "additional_components": [ "O18061", "WBGene00021994", "D6RYE3", "WBGene00021994", "Q18771", "WBGene00021994", "G8JZM6", "WBGene00021994", "Q9TYX7", "WBGene00021994", "O18057", "WBGene00021994" ] }, "reaction_10514075": { "compartment": "compartment_70101", "id": "reaction_10514075", "reactome": "R-CEL-198813", "name": "GSTO dimers reduce DeHA to AscH-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29450", "species_198827" ], "products": [ "species_198816", "species_111745" ], "modifiers": [ [ "species_10514072", "catalyst" ] ], "additional_components": [ "P34277", "WBGene00015337", "D7SFI3", "WBGene00043097", "P34345", "WBGene00016204", "O17234", "WBGene00019636", "O45352", "WBGene00001792" ] }, "reaction_10514141": { "compartment": "compartment_70101", "id": "reaction_10514141", "reactome": "R-CEL-198824", "name": "CYB5R3:FAD reduces CYB5A:ferriheme to CYB5A:heme", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_73473", "species_10514128" ], "products": [ "species_10514130", "species_29360" ], "modifiers": [ [ "species_10514138", "catalyst" ] ], "additional_components": [ "CHEBI:36144", "O01816", "WBGene00020931", "Q93315", "WBGene00007848", "species_71185", "O01816", "WBGene00020931", "Q93315", "WBGene00007848", "O16521", "WBGene00020268", "species_113596" ] }, "reaction_10529632": { "compartment": "compartment_70101", "id": "reaction_10529632", "reactome": "R-CEL-964958", "name": "2xPDXK:2xZn2+ phosphorylates PXA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_964945", "species_113592" ], "products": [ "species_29370", "species_965146" ], "modifiers": [ [ "species_10529629", "catalyst" ] ], "additional_components": [ "species_216785", "O01824", "WBGene00019008" ] }, "reaction_10529648": { "compartment": "compartment_70101", "id": "reaction_10529648", "reactome": "R-CEL-965079", "name": "2xPNPO:2xFMN oxidizes PXAP to PXLP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_29368", "species_965146" ], "products": [ "species_29390", "species_31633", "species_29408" ], "modifiers": [ [ "species_10529643", "catalyst" ] ], "additional_components": [ "species_73524", "Q20939", "WBGene00018996" ] }, "reaction_10529634": { "compartment": "compartment_70101", "id": "reaction_10529634", "reactome": "R-CEL-964962", "name": "2xPDKX:2xZn2+ phosphorylates PDX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_965053" ], "products": [ "species_29370", "species_964952" ], "modifiers": [ [ "species_10529629", "catalyst" ] ], "additional_components": [ "species_216785", "O01824", "WBGene00019008" ] }, "reaction_10529636": { "compartment": "compartment_70101", "id": "reaction_10529636", "reactome": "R-CEL-964970", "name": "2xPDXK:2xZn2+ phosphorylates PXL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_965131" ], "products": [ "species_29390", "species_29370" ], "modifiers": [ [ "species_10529629", "catalyst" ] ], "additional_components": [ "species_216785", "O01824", "WBGene00019008" ] }, "reaction_10546502": { "compartment": "compartment_70101", "id": "reaction_10546502", "reactome": "R-CEL-3204311", "name": "AOX1 oxidises PXL to PDXate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_29368", "species_965131" ], "products": [ "species_3204324", "species_29408" ], "modifiers": [ [ "species_10546499", "catalyst" ] ], "additional_components": [ "CHEBI:33722", "CHEBI:44074", "species_113596", "O17892", "WBGene00010083", "O61198", "WBGene00017487", "Q960A1", "WBGene00015057" ] }, "reaction_10529646": { "compartment": "compartment_70101", "id": "reaction_10529646", "reactome": "R-CEL-965019", "name": "2xPNPO:2xFMN oxidizes PDXP to PXLP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_964952" ], "products": [ "species_29390", "species_29408" ], "modifiers": [ [ "species_10529643", "catalyst" ] ], "additional_components": [ "species_73524", "Q20939", "WBGene00018996" ] }, "reaction_10513776": { "compartment": "compartment_70101", "id": "reaction_10513776", "reactome": "R-CEL-197235", "name": "NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_197220" ], "products": [ "species_197256", "species_1132084" ], "modifiers": [ [ "species_10513773", "catalyst" ] ], "additional_components": [ "species_114632", "P91851", "WBGene00009176", "Q9XXM2", "WBGene00012295" ] }, "reaction_10514608": { "compartment": "compartment_5460", "id": "reaction_10514608", "reactome": "R-CEL-200474", "name": "NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8938083", "species_113593" ], "products": [ "species_8938078", "species_8938090" ], "modifiers": [ [ "species_10514605", "catalyst" ] ], "additional_components": [ "species_114632", "P91851", "WBGene00009176", "Q9XXM2", "WBGene00012295" ] }, "reaction_10523473": { "compartment": "compartment_876", "id": "reaction_10523473", "reactome": "R-CEL-429749", "name": "SLC5A8 transports monocarboxylates from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_429739", "species_74113" ], "products": [ "species_83910", "species_429748" ], "modifiers": [ [ "species_10523470", "catalyst" ] ], "additional_components": [ "species_113557", "species_29708", "species_8869604", "CHEBI:30772", "species_427486", "CHEBI:30768", "CHEBI:30772", "species_113557", "species_427486", "species_29708", "CHEBI:30768", "species_197230", "WBGene00018716" ] }, "reaction_10563652": { "compartment": "compartment_17951", "id": "reaction_10563652", "reactome": "R-CEL-6809287", "name": "NUDT12 hydrolyses NADH to NMNH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_141343", "species_192305", "species_389620" ], "products": [ "species_6809289", "species_193465" ], "modifiers": [ [ "species_10563649", "catalyst" ] ], "additional_components": [ "WBGene00003586" ] }, "reaction_10563127": { "compartment": "compartment_5460", "id": "reaction_10563127", "reactome": "R-CEL-6806967", "name": "CARKD dehydrates S-NAD(P)HX to NADPH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113593", "species_6807477" ], "products": [ "species_113548", "species_113581", "species_113529", "species_113600" ], "modifiers": [ [ "species_10563124", "catalyst" ] ], "additional_components": [ "WBGene00011298" ] }, "reaction_10566729": { "compartment": "compartment_876", "id": "reaction_10566729", "reactome": "R-CEL-8869603", "name": "SLC22A13 transports NCA from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8869604" ], "products": [ "species_197230" ], "modifiers": [ [ "species_10566726", "catalyst" ] ], "additional_components": [ "WBGene00020701" ] }, "reaction_10551672": { "compartment": "compartment_70101", "id": "reaction_10551672", "reactome": "R-CEL-5359451", "name": "NNMT transfers CH3 from SAM to NAM to form MNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_197277", "species_71284" ], "products": [ "species_549282", "species_71285" ], "modifiers": [ [ "species_10511828", "catalyst" ] ], "additional_components": [ "WBGene00015124" ] }, "reaction_10563119": { "compartment": "compartment_5460", "id": "reaction_10563119", "reactome": "R-CEL-6806966", "name": "APOA1BP dimer epimerises R-NAD(P)HX to S-NAD(P)HX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6807473" ], "products": [ "species_6807477" ], "modifiers": [ [ "species_10563116", "catalyst" ] ], "additional_components": [ "Q9XW15", "WBGene00012476" ] }, "reaction_10513759": { "compartment": "compartment_70101", "id": "reaction_10513759", "reactome": "R-CEL-197186", "name": "NAPRT1 dimer transfers PRIB to NCA to form NAMN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73566", "species_197230", "species_70106" ], "products": [ "species_111294", "species_197220" ], "modifiers": [ [ "species_10513756", "catalyst" ], [ "species_29926", "catalyst" ] ], "additional_components": [ "Q95XX1", "WBGene00021882" ] }, "reaction_10568517": { "compartment": "compartment_70101", "id": "reaction_10568517", "reactome": "R-CEL-8939959", "name": "NMNAT2 transfers an adenylyl group from ATP to NMN to yield NAD+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8869353", "species_113592" ], "products": [ "species_1132084", "species_29360" ], "modifiers": [ [ "species_10513773", "catalyst" ] ], "additional_components": [ "species_114632", "P91851", "WBGene00009176", "Q9XXM2", "WBGene00012295" ] }, "reaction_10514615": { "compartment": "compartment_7660", "id": "reaction_10514615", "reactome": "R-CEL-200512", "name": "NMNAT1 transfers an adenylyl group from ATP to NAMN to yield NAAD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200492", "species_29358" ], "products": [ "species_8878981", "species_200499" ], "modifiers": [ [ "species_10514612", "catalyst" ] ], "additional_components": [ "P91851", "WBGene00009176", "species_216785" ] }, "reaction_10569958": { "compartment": "compartment_5460", "id": "reaction_10569958", "reactome": "R-CEL-8955030", "name": "NADK2 dimer phosphorylates NAD+ to NADP+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113593", "species_113526" ], "products": [ "species_113581", "species_113563", "species_113529" ], "modifiers": [ [ "species_10569955", "catalyst" ] ], "additional_components": [ "Q9XXI5", "WBGene00012463" ] }, "reaction_10513786": { "compartment": "compartment_70101", "id": "reaction_10513786", "reactome": "R-CEL-197271", "name": "NADSYN1 hexamer amidates NAAD to NAD+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_197256", "species_113592", "species_29472" ], "products": [ "species_111294", "species_29404", "species_76577", "species_29360" ], "modifiers": [ [ "species_10513783", "catalyst" ] ], "additional_components": [ "Q9XXK6", "WBGene00007698" ] }, "reaction_10513714": { "compartment": "compartment_70101", "id": "reaction_10513714", "reactome": "R-CEL-196840", "name": "3xPPCDC:3FMN decarboxylates PPC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_196834" ], "products": [ "species_196767", "species_113528" ], "modifiers": [ [ "species_10513711", "catalyst" ] ], "additional_components": [ "species_73524", "P91988", "WBGene00009138" ] }, "reaction_10513683": { "compartment": "compartment_70101", "id": "reaction_10513683", "reactome": "R-CEL-196753", "name": "2xPPCS ligates PPanK with Cys", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111707", "species_113592", "species_196786" ], "products": [ "species_111294", "species_196834", "species_76577" ], "modifiers": [ [ "species_10513680", "catalyst" ] ], "additional_components": [ "Q9BL36", "WBGene00022171" ] }, "reaction_10513704": { "compartment": "compartment_70101", "id": "reaction_10513704", "reactome": "R-CEL-196773", "name": "COASY phosphorylates DP-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_196778" ], "products": [ "species_29370", "species_76194" ], "modifiers": [ [ "species_10513688", "catalyst" ] ], "additional_components": [ "WBGene00022031" ] }, "reaction_10513691": { "compartment": "compartment_70101", "id": "reaction_10513691", "reactome": "R-CEL-196754", "name": "COASY transfers an adenylyl group from ATP to PPANT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_196767", "species_113592" ], "products": [ "species_111294", "species_196778" ], "modifiers": [ [ "species_10513688", "catalyst" ] ], "additional_components": [ "WBGene00022031" ] }, "reaction_10514238": { "compartment": "compartment_70101", "id": "reaction_10514238", "reactome": "R-CEL-199202", "name": "Phosphopantetheine conjugation of the ACP domain of FAS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10514230", "species_76194" ], "products": [ "species_10507450", "species_158466" ], "modifiers": [ [ "species_10514235", "catalyst" ] ], "additional_components": [ "WBGene00009342", "WBGene00009342", "WBGene00012142" ] }, "reaction_10567381": { "compartment": "compartment_17927", "id": "reaction_10567381", "reactome": "R-CEL-8875838", "name": "SLC25A19 transports ThDP from cytosol to mitochondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29480" ], "products": [ "species_8878387" ], "modifiers": [ [ "species_10567378", "catalyst" ] ], "additional_components": [ "WBGene00016588" ] }, "reaction_10513701": { "compartment": "compartment_70101", "id": "reaction_10513701", "reactome": "R-CEL-196761", "name": "2xTPK1:Mg2+ phosphorylates THMN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_196934" ], "products": [ "species_29480", "species_76577" ], "modifiers": [ [ "species_10513698", "catalyst" ] ], "additional_components": [ "P30636", "WBGene00014027", "species_114632" ] }, "reaction_10514362": { "compartment": "compartment_876", "id": "reaction_10514362", "reactome": "R-CEL-199626", "name": "SLC19A2/3 transport extracellular THMN to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_199622" ], "products": [ "species_196934" ], "modifiers": [ [ "species_10514359", "catalyst" ] ], "additional_components": [ "Q22931", "WBGene00044738", "O45166", "WBGene00018138", "Q17766", "WBGene00007388" ] }, "reaction_10546096": { "compartment": "compartment_70101", "id": "reaction_10546096", "reactome": "R-CEL-2993799", "name": "HLCS biotinylates 6xMCCC1:6xMCCC2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546090", "species_113592", "species_199207" ], "products": [ "species_111294", "species_10546094", "species_76577" ], "modifiers": [ [ "species_10546065", "catalyst" ] ], "additional_components": [ "O45430", "WBGene00009319", "P34385", "WBGene00303021", "P34385", "WBGene00303021", "O45430", "WBGene00009319", "WBGene00000259" ] }, "reaction_10546068": { "compartment": "compartment_70101", "id": "reaction_10546068", "reactome": "R-CEL-2993447", "name": "HLCS biotinylates 6x(PCCA:PCCB)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10546054", "species_199207" ], "products": [ "species_111294", "species_10546060", "species_76577" ], "modifiers": [ [ "species_10546065", "catalyst" ] ], "additional_components": [ "Q20676", "WBGene00018701", "Q19842", "WBGene00017864", "Q20676", "WBGene00018701", "Q19842", "WBGene00017864", "WBGene00000259" ] }, "reaction_10546117": { "compartment": "compartment_70101", "id": "reaction_10546117", "reactome": "R-CEL-2993814", "name": "HLCS biotinylates ACACA:Mn2+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_199207", "species_10546115" ], "products": [ "species_111294", "species_10507413", "species_76577" ], "modifiers": [ [ "species_10546065", "catalyst" ] ], "additional_components": [ "H2L0M0", "WBGene00004076", "Q9XUC3", "WBGene00012131", "species_266099", "Q9XUC3", "WBGene00012131", "H2L0M0", "WBGene00004076", "species_266099", "WBGene00000259" ] }, "reaction_10549065": { "compartment": "compartment_70101", "id": "reaction_10549065", "reactome": "R-CEL-4167511", "name": "HLCS biotinylates ACACB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10549063", "species_199207" ], "products": [ "species_111294", "species_10514575", "species_76577" ], "modifiers": [ [ "species_10546065", "catalyst" ] ], "additional_components": [ "H2L0M0", "WBGene00004076", "species_266099", "species_266099", "H2L0M0", "WBGene00004076", "WBGene00000259" ] }, "reaction_10546107": { "compartment": "compartment_70101", "id": "reaction_10546107", "reactome": "R-CEL-2993802", "name": "HLCS biotinylates PC:Mn2+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_199207", "species_10546100" ], "products": [ "species_111294", "species_10546105", "species_76577" ], "modifiers": [ [ "species_10546065", "catalyst" ] ], "additional_components": [ "O17732", "WBGene00004258", "species_266099", "O17732", "WBGene00004258", "species_266099", "WBGene00000259" ] }, "reaction_10547436": { "compartment": "compartment_70101", "id": "reaction_10547436", "reactome": "R-CEL-3323111", "name": "Cytoslic carboxylases translocate to mitochondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10547434" ], "products": [ "species_10546283" ], "modifiers": [], "additional_components": [ "O17732", "WBGene00004258", "species_266099", "Q20676", "WBGene00018701", "Q19842", "WBGene00017864", "P34385", "WBGene00303021", "O45430", "WBGene00009319", "species_266099", "O17732", "WBGene00004258", "Q19842", "WBGene00017864", "Q20676", "WBGene00018701", "P34385", "WBGene00303021", "O45430", "WBGene00009319" ] }, "reaction_10529569": { "compartment": "compartment_70101", "id": "reaction_10529569", "reactome": "R-CEL-947535", "name": "Cyclisation of GTP to precursor Z", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_29356", "species_71284" ], "products": [ "species_111294", "species_947537", "species_947703", "species_174390" ], "modifiers": [ [ "species_10529566", "catalyst" ] ], "additional_components": [ "CHEBI:33722", "Q20624", "WBGene00009885" ] }, "reaction_10529522": { "compartment": "compartment_70101", "id": "reaction_10529522", "reactome": "R-CEL-947499", "name": "Exchange of oxygen with sulfur in MoCo", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_947539", "species_111707" ], "products": [ "species_947575", "species_29432" ], "modifiers": [ [ "species_10529519", "catalyst" ] ], "additional_components": [ "WBGene00010983" ] }, "reaction_10529557": { "compartment": "compartment_70101", "id": "reaction_10529557", "reactome": "R-CEL-947531", "name": "Molybdenum ion transfer onto molybdopterin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_947561", "species_947496" ], "products": [ "species_111294", "species_947539", "species_76577" ], "modifiers": [ [ "species_10529554", "catalyst" ] ], "additional_components": [ "species_114632", "G5EGH2", "WBGene00003384" ] }, "reaction_10529545": { "compartment": "compartment_70101", "id": "reaction_10529545", "reactome": "R-CEL-947514", "name": "PXLP-K258-NFS1 transfers sulfur from cysteine onto MOCS3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111707", "species_10529529" ], "products": [ "species_10529534", "species_29432" ], "modifiers": [ [ "species_10529542", "catalyst" ] ], "additional_components": [ "species_216785", "O44510", "WBGene00018357", "species_216785", "O44510", "WBGene00018357", "O61741", "WBGene00015021" ] }, "reaction_10513732": { "compartment": "compartment_70101", "id": "reaction_10513732", "reactome": "R-CEL-196950", "name": "2xTRAP hydrolyzes FMN to RIB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_73524" ], "products": [ "species_29372", "species_196931" ], "modifiers": [ [ "species_10513729", "catalyst" ] ], "additional_components": [ "O01320", "WBGene00008531" ] }, "reaction_10513749": { "compartment": "compartment_70101", "id": "reaction_10513749", "reactome": "R-CEL-196955", "name": "2xENPP1 hydrolyzes FAD to FMN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_29386" ], "products": [ "species_73524", "species_76577" ], "modifiers": [ [ "species_10513746", "catalyst" ] ], "additional_components": [ "P90754", "WBGene00007755", "P90755", "WBGene00007755" ] }, "reaction_10513722": { "compartment": "compartment_70101", "id": "reaction_10513722", "reactome": "R-CEL-196929", "name": "FLAD1 phosphorylates FMN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_73524" ], "products": [ "species_111294", "species_29386" ], "modifiers": [ [ "species_10513719", "catalyst" ] ], "additional_components": [ "WBGene00011271" ] }, "reaction_10546475": { "compartment": "compartment_70101", "id": "reaction_10546475", "reactome": "R-CEL-3165230", "name": "SLC52A1,2,3 transport RIB from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_3165253" ], "products": [ "species_196931" ], "modifiers": [ [ "species_10546472", "catalyst" ], [ "species_73524", "inhibitor" ], [ "species_29386", "inhibitor" ] ], "additional_components": [ "G4SDH4", "WBGene00021626", "Q3LFN0", "WBGene00044637" ] }, "reaction_10546433": { "compartment": "compartment_70101", "id": "reaction_10546433", "reactome": "R-CEL-3149519", "name": "MMACHC decyanates CNCbl", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_3149505", "species_10546288" ], "products": [ "species_29366", "species_1130611", "species_10546290" ], "modifiers": [ [ "species_10546288", "catalyst" ] ], "additional_components": [ "WBGene00022766", "Q7Z144", "WBGene00022766", "species_3149479", "WBGene00022766" ] }, "reaction_10546436": { "compartment": "compartment_70101", "id": "reaction_10546436", "reactome": "R-CEL-3149539", "name": "MTR transfers CH3 group from MTHF to cob(I)alamin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200665", "species_10511764" ], "products": [ "species_111355", "species_10511760" ], "modifiers": [ [ "species_10511764", "catalyst" ] ], "additional_components": [ "species_216785", "species_3159260", "Q09582", "WBGene00010988", "species_73524", "Q17574", "WBGene00006510", "species_113596", "species_73524", "Q17574", "WBGene00006510", "species_113596", "species_216785", "CHEBI:28115", "Q09582", "WBGene00010988", "species_216785", "species_3159260", "Q09582", "WBGene00010988", "species_73524", "Q17574", "WBGene00006510", "species_113596" ] }, "reaction_10550725": { "compartment": "compartment_70101", "id": "reaction_10550725", "reactome": "R-CEL-5223313", "name": "ABCD4 may transport Cbl from lysosomal lumen to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_3000239" ], "products": [ "species_29372", "species_3000241", "species_29370" ], "modifiers": [ [ "species_10550722", "catalyst" ] ], "additional_components": [ "WBGene00004060" ] }, "reaction_10546438": { "compartment": "compartment_70101", "id": "reaction_10546438", "reactome": "R-CEL-3149563", "name": "MMADHC targets transport of cytosolic cob(II)alamin to mitochondria", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546415" ], "products": [ "species_3149564", "species_10546417" ], "modifiers": [], "additional_components": [ "Q7Z144", "WBGene00022766", "species_3149479", "Q9XWC9", "WBGene00013577", "Q7Z144", "WBGene00022766", "Q9XWC9", "WBGene00013577" ] }, "reaction_10546504": { "compartment": "compartment_70101", "id": "reaction_10546504", "reactome": "R-CEL-3204318", "name": "cob(II)alamin binds to MTRR:MTR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546425", "species_3149479" ], "products": [ "species_10546427" ], "modifiers": [], "additional_components": [ "species_73524", "Q17574", "WBGene00006510", "species_113596", "species_216785", "Q09582", "WBGene00010988", "species_3149479", "species_73524", "Q17574", "WBGene00006510", "species_113596", "species_216785", "Q09582", "WBGene00010988" ] }, "reaction_10546448": { "compartment": "compartment_5460", "id": "reaction_10546448", "reactome": "R-CEL-3159253", "name": "MMAB transfers adenosyl group from ATP to cob(I)alamin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_3159260", "species_113593" ], "products": [ "species_3159274", "species_3159297" ], "modifiers": [ [ "species_10546445", "catalyst" ] ], "additional_components": [ "Q18218", "WBGene00016144" ] }, "reaction_10546450": { "compartment": "compartment_5460", "id": "reaction_10546450", "reactome": "R-CEL-3159259", "name": "MMAA:MUT binds AdoCbl", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10503659", "species_3159297" ], "products": [ "species_10503661" ], "modifiers": [], "additional_components": [ "Q22111", "WBGene00020169", "Q23381", "WBGene00014202", "species_3159297", "Q22111", "WBGene00020169", "Q23381", "WBGene00014202" ] }, "reaction_10503666": { "compartment": "compartment_5460", "id": "reaction_10503666", "reactome": "R-CEL-71010", "name": "MUT isomerises L-MM-CoA to SUCC-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71009" ], "products": [ "species_70958" ], "modifiers": [ [ "species_10503661", "catalyst" ] ], "additional_components": [ "species_3159297", "Q22111", "WBGene00020169", "Q23381", "WBGene00014202" ] }, "reaction_10546419": { "compartment": "compartment_70101", "id": "reaction_10546419", "reactome": "R-CEL-3149492", "name": "cob(II)alamin dissociates from MMACHC:MMADHC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546415" ], "products": [ "species_3149479", "species_10546417" ], "modifiers": [], "additional_components": [ "Q7Z144", "WBGene00022766", "species_3149479", "Q9XWC9", "WBGene00013577", "Q7Z144", "WBGene00022766", "Q9XWC9", "WBGene00013577" ] }, "reaction_10546293": { "compartment": "compartment_70101", "id": "reaction_10546293", "reactome": "R-CEL-3095889", "name": "MMACHC reduces Cbl", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_3000241", "species_70106", "species_29364", "species_10546288" ], "products": [ "species_29366", "species_10546290" ], "modifiers": [ [ "species_10546288", "catalyst" ] ], "additional_components": [ "WBGene00022766", "Q7Z144", "WBGene00022766", "species_3149479", "WBGene00022766" ] }, "reaction_10546421": { "compartment": "compartment_70101", "id": "reaction_10546421", "reactome": "R-CEL-3149494", "name": "MMACHC:cob(II)alamin binds MMADHC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546413", "species_10546290" ], "products": [ "species_10546415" ], "modifiers": [], "additional_components": [ "WBGene00013577", "Q7Z144", "WBGene00022766", "species_3149479", "Q7Z144", "WBGene00022766", "species_3149479", "Q9XWC9", "WBGene00013577" ] }, "reaction_10546296": { "compartment": "compartment_70101", "id": "reaction_10546296", "reactome": "R-CEL-3095901", "name": "ABCC1 transports cytosolic Cbl to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_3000241", "species_113592" ], "products": [ "species_29372", "species_29370", "species_3000125" ], "modifiers": [ [ "species_10517853", "catalyst" ] ], "additional_components": [ "WBGene00003407" ] }, "reaction_10546430": { "compartment": "compartment_70101", "id": "reaction_10546430", "reactome": "R-CEL-3149518", "name": "MTRR reduces cob(II)alamin to meCbl", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_10546427", "species_71284", "species_29364" ], "products": [ "species_29366", "species_71285", "species_10511760" ], "modifiers": [ [ "species_10546427", "catalyst" ] ], "additional_components": [ "species_3149479", "species_73524", "Q17574", "WBGene00006510", "species_113596", "species_216785", "Q09582", "WBGene00010988", "species_73524", "Q17574", "WBGene00006510", "species_113596", "species_216785", "CHEBI:28115", "Q09582", "WBGene00010988", "species_3149479", "species_73524", "Q17574", "WBGene00006510", "species_113596", "species_216785", "Q09582", "WBGene00010988" ] }, "reaction_10535154": { "compartment": "compartment_70101", "id": "reaction_10535154", "reactome": "R-CEL-1497796", "name": "BH2 binding can lead to eNOS uncoupling", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10515166", "species_1497857" ], "products": [ "species_29870", "species_10535152" ], "modifiers": [], "additional_components": [ "Q9XTG7", "WBGene00000103", "G4S4W1", "WBGene00016980", "Q17941", "WBGene00000102", "species_74016", "Q11083", "WBGene00020378", "P04630", "WBGene00000285", "G5EF37", "WBGene00003934", "A0A2C9C3L3", "WBGene00020378", "Q18136", "WBGene00006861", "Q09665", "WBGene00006583", "O02159", "WBGene00020378", "G5EDZ8", "WBGene00000288", "Q94288", "WBGene00000287", "Q09980", "WBGene00017394", "O16305", "WBGene00000552", "G5EEG0", "WBGene00000286", "Q18688", "WBGene00000915", "species_71185", "species_216785", "species_73524", "species_113596", "species_29870", "Q9XTG7", "WBGene00000103", "G4S4W1", "WBGene00016980", "Q17941", "WBGene00000102", "species_74016", "Q11083", "WBGene00020378", "P04630", "WBGene00000285", "G5EF37", "WBGene00003934", "A0A2C9C3L3", "WBGene00020378", "Q18136", "WBGene00006861", "Q09665", "WBGene00006583", "O02159", "WBGene00020378", "G5EDZ8", "WBGene00000288", "Q94288", "WBGene00000287", "Q09980", "WBGene00017394", "O16305", "WBGene00000552", "G5EEG0", "WBGene00000286", "Q18688", "WBGene00000915", "species_1497857", "species_71185", "species_216785", "species_73524", "species_113596", "species_29870" ] }, "reaction_10534357": { "compartment": "compartment_70101", "id": "reaction_10534357", "reactome": "R-CEL-1474184", "name": "DHNTP is dephosphorylated by PTPS to PTHP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1474124" ], "products": [ "species_1475054", "species_1474179" ], "modifiers": [ [ "species_10534354", "catalyst" ] ], "additional_components": [ "O02058", "WBGene00015010", "species_216785" ] }, "reaction_10534343": { "compartment": "compartment_70101", "id": "reaction_10534343", "reactome": "R-CEL-1474146", "name": "GCH1 reduces GTP to dihydroneopterin triphosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_29356" ], "products": [ "species_1474124", "species_29460" ], "modifiers": [ [ "species_10534331", "catalyst" ], [ "species_29502", "catalyst" ], [ "species_29870", "inhibitor" ], [ "species_10534341", "inhibitor" ] ], "additional_components": [ "Q19980", "WBGene00000298", "D6RYD9", "WBGene00044736", "Q19980", "WBGene00000298" ] }, "reaction_10534712": { "compartment": "compartment_70101", "id": "reaction_10534712", "reactome": "R-CEL-1475422", "name": "PTPS is phosphorylated by cGMP-dependant protein kinase II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10534700", "species_113592" ], "products": [ "species_29370", "species_10534354" ], "modifiers": [ [ "species_10534709", "catalyst" ] ], "additional_components": [ "O02058", "WBGene00015010", "O02058", "WBGene00015010", "species_216785", "H2KYN2", "WBGene00015650", "O76360", "WBGene00001173" ] }, "reaction_10534346": { "compartment": "compartment_70101", "id": "reaction_10534346", "reactome": "R-CEL-1474158", "name": "GCHFR binds to GCH1 and negatively regulates its activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10534331", "species_10534339" ], "products": [ "species_10534341" ], "modifiers": [], "additional_components": [ "Q19980", "WBGene00000298", "D6RYD9", "WBGene00044736", "D6RYD9", "WBGene00044736", "Q19980", "WBGene00000298" ] }, "reaction_10520593": { "compartment": "compartment_70101", "id": "reaction_10520593", "reactome": "R-CEL-389540", "name": "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_389545", "species_29366" ], "products": [ "species_29406", "species_70106", "species_113528", "species_29364" ], "modifiers": [ [ "species_10520590", "catalyst" ] ], "additional_components": [ "H9G2T4", "WBGene00010317" ] }, "reaction_10552560": { "compartment": "compartment_70101", "id": "reaction_10552560", "reactome": "R-CEL-5578910", "name": "KCNK dimers transport K+ from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10552557", "catalyst" ] ], "additional_components": [ "O17185", "WBGene00006318", "Q10937", "WBGene00015137", "Q9NEV3", "WBGene00006696", "G5ECW6", "WBGene00006673" ] }, "reaction_10572199": { "compartment": "compartment_7660", "id": "reaction_10572199", "reactome": "R-CEL-9617927", "name": "FOXO4 binds ATXN3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10556072", "species_10514278" ], "products": [ "species_10572197" ], "modifiers": [], "additional_components": [ "WBGene00006446", "WBGene00000912", "O16850", "WBGene00000912", "O17850", "WBGene00006446" ] }, "reaction_10572203": { "compartment": "compartment_7660", "id": "reaction_10572203", "reactome": "R-CEL-9617996", "name": "FOXO1,FOXO3,FOXO4 bind p-2S-SMAD2/3:SMAD4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10511518", "species_10514274" ], "products": [ "species_10572201" ], "modifiers": [], "additional_components": [ "P45897", "WBGene00004858", "Q21733", "WBGene00000904", "WBGene00000912", "O16850", "WBGene00000912", "P45897", "WBGene00004858", "Q21733", "WBGene00000904" ] }, "reaction_10572288": { "compartment": "compartment_7660", "id": "reaction_10572288", "reactome": "R-CEL-9626928", "name": "CREBBP binds FOXO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10532226", "species_10514274" ], "products": [ "species_10572286" ], "modifiers": [], "additional_components": [ "WBGene00000366", "WBGene00000912", "O16850", "WBGene00000912", "P34545", "WBGene00000366" ] }, "reaction_10572248": { "compartment": "compartment_7660", "id": "reaction_10572248", "reactome": "R-CEL-9620515", "name": "KAT2B,EP300 acetylate FOXO3 under oxidative stress", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113560", "species_10514276" ], "products": [ "species_2485002", "species_10572243" ], "modifiers": [ [ "species_10572245", "catalyst" ], [ "species_3785707", "catalyst" ] ], "additional_components": [ "WBGene00000912", "WBGene00000912", "Q9N3S7", "WBGene00021636" ] }, "reaction_10572251": { "compartment": "compartment_7660", "id": "reaction_10572251", "reactome": "R-CEL-9620532", "name": "SIRT1,SIRT3 deacetylate FOXO3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_427523", "species_10572243" ], "products": [ "species_427497", "species_427498", "species_10514276" ], "modifiers": [ [ "species_10522802", "catalyst" ] ], "additional_components": [ "WBGene00000912", "WBGene00000912", "WBGene00004800" ] }, "reaction_10572161": { "compartment": "compartment_70101", "id": "reaction_10572161", "reactome": "R-CEL-9614423", "name": "14-3-3 proteins bind AKT-phosphorylated FOXO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10572157", "species_10516880" ], "products": [ "species_10572159" ], "modifiers": [], "additional_components": [ "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "WBGene00000912", "O16850", "WBGene00000912", "P41932", "WBGene00003920", "Q20655", "WBGene00001502" ] }, "reaction_10572167": { "compartment": "compartment_70101", "id": "reaction_10572167", "reactome": "R-CEL-9614562", "name": "14-3-3 proteins bind AKT-phosphorylated FOXO3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10572151", "species_10572163" ], "products": [ "species_10572165" ], "modifiers": [], "additional_components": [ "WBGene00000912", "Q20655", "WBGene00001502", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "P41932", "WBGene00003920", "O16850", "WBGene00000912" ] }, "reaction_10572155": { "compartment": "compartment_7660", "id": "reaction_10572155", "reactome": "R-CEL-9614414", "name": "AKT-phosphorylated FOXO1,FOXO3,FOXO4 translocate to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10514285" ], "products": [ "species_10516880" ], "modifiers": [], "additional_components": [ "WBGene00000912", "WBGene00000912" ] }, "reaction_10572171": { "compartment": "compartment_70101", "id": "reaction_10572171", "reactome": "R-CEL-9614564", "name": "14-3-3 proteins bind AKT-phosphorylated FOXO4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10572153", "species_10507059" ], "products": [ "species_10572169" ], "modifiers": [], "additional_components": [ "WBGene00000912", "Q20655", "WBGene00001502", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "P41932", "WBGene00003920", "O16850", "WBGene00000912" ] }, "reaction_10569079": { "compartment": "compartment_7660", "id": "reaction_10569079", "reactome": "R-CEL-8951966", "name": "EP300 acetylates RUNX3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10569066", "species_113560" ], "products": [ "species_2485002", "species_10569076" ], "modifiers": [ [ "species_10569066", "catalyst" ], [ "species_10511431", "catalyst" ] ], "additional_components": [ "P34545", "WBGene00000366", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "G5EFQ5", "WBGene00004393", "Q95ZL9", "WBGene00000272", "P34545", "WBGene00000366", "P34545", "WBGene00000366", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "G5EBY8", "WBGene00006852", "G5EEL5", "WBGene00000936" ] }, "reaction_10569160": { "compartment": "compartment_7660", "id": "reaction_10569160", "reactome": "R-CEL-8952062", "name": "CCND1 recruits HDAC4 to RUNX3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10549372", "species_10569156" ], "products": [ "species_10569158" ], "modifiers": [], "additional_components": [ "WBGene00001837", "G5EFQ5", "WBGene00004393", "Q95ZL9", "WBGene00000272", "O76561", "WBGene00017423", "Q95Y80", "WBGene00022473", "A0A0K3AWB8", "F57C7.1d", "G5EFQ5", "WBGene00004393", "Q95ZL9", "WBGene00000272", "O76561", "WBGene00017423", "Q95Y80", "WBGene00022473", "A0A0K3AWB8", "F57C7.1d", "O17323", "WBGene00001837" ] }, "reaction_10569165": { "compartment": "compartment_7660", "id": "reaction_10569165", "reactome": "R-CEL-8952069", "name": "HDAC4 deacetylates RUNX3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10569158" ], "products": [ "species_10569098", "species_10569162", "species_427486" ], "modifiers": [ [ "species_10569158", "catalyst" ] ], "additional_components": [ "G5EFQ5", "WBGene00004393", "Q95ZL9", "WBGene00000272", "O76561", "WBGene00017423", "Q95Y80", "WBGene00022473", "A0A0K3AWB8", "F57C7.1d", "O17323", "WBGene00001837", "O76561", "WBGene00017423", "Q95Y80", "WBGene00022473", "A0A0K3AWB8", "F57C7.1d", "O17323", "WBGene00001837", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "G5EFQ5", "WBGene00004393", "Q95ZL9", "WBGene00000272", "O76561", "WBGene00017423", "Q95Y80", "WBGene00022473", "A0A0K3AWB8", "F57C7.1d", "O17323", "WBGene00001837" ] }, "reaction_10569068": { "compartment": "compartment_7660", "id": "reaction_10569068", "reactome": "R-CEL-8951951", "name": "RUNX3 binds EP300", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10566207", "species_10532228" ], "products": [ "species_10569066" ], "modifiers": [], "additional_components": [ "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "WBGene00000366", "P34545", "WBGene00000366", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393" ] }, "reaction_10569102": { "compartment": "compartment_7660", "id": "reaction_10569102", "reactome": "R-CEL-8951977", "name": "Acetylated RUNX3 binds to BRD2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10569098", "species_10569076" ], "products": [ "species_10569100" ], "modifiers": [ [ "species_10549046", "catalyst" ] ], "additional_components": [ "O76561", "WBGene00017423", "Q95Y80", "WBGene00022473", "A0A0K3AWB8", "F57C7.1d", "G5EFQ5", "WBGene00004393", "Q95ZL9", "WBGene00000272", "P34545", "WBGene00000366", "G5EFQ5", "WBGene00004393", "Q95ZL9", "WBGene00000272", "P34545", "WBGene00000366", "O76561", "WBGene00017423", "Q95Y80", "WBGene00022473", "A0A0K3AWB8", "F57C7.1d", "P22981", "WBGene00002335", "species_29438" ] }, "reaction_10570708": { "compartment": "compartment_7660", "id": "reaction_10570708", "reactome": "R-CEL-9008822", "name": "PPM1D dephosphorylates RUNX2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10570700" ], "products": [ "species_10567753", "species_113541" ], "modifiers": [ [ "species_10570705", "catalyst" ] ], "additional_components": [ "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "G5EFQ5", "WBGene00004393", "Q95ZL9", "WBGene00000272", "WBGene00021856" ] }, "reaction_10568512": { "compartment": "compartment_7660", "id": "reaction_10568512", "reactome": "R-CEL-8939706", "name": "SCF(SKP2) polyubiquitinates RUNX2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502318", "species_10568502" ], "products": [ "species_10568507", "species_10502340" ], "modifiers": [ [ "species_10568502", "catalyst" ] ], "additional_components": [ "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "G5EFQ5", "WBGene00004393", "Q23457", "WBGene00004320", "G5ECU1", "WBGene00004807", "Q17389", "WBGene00000836", "WBGene00004393", "Q23457", "WBGene00004320", "G5ECU1", "WBGene00004807", "Q17389", "WBGene00000836", "G5EFQ5", "WBGene00004393", "Q23457", "WBGene00004320", "G5ECU1", "WBGene00004807", "Q17389", "WBGene00000836" ] }, "reaction_10568514": { "compartment": "compartment_7660", "id": "reaction_10568514", "reactome": "R-CEL-8939801", "name": "26S proteasome degrades PolyUb-RUNX2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10568507" ], "products": [ "species_10502318" ], "modifiers": [ [ "species_10512606", "catalyst" ] ], "additional_components": [ "WBGene00004393", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "Q23237", "WBGene00003949", "P90868", "WBGene00003953", "Q9XUV0", "WBGene00003951", "Q966I8", "WBGene00003947", "O62102", "WBGene00003948", "O16368", "WBGene00004502", "Q18787", "WBGene00004501", "O76371", "WBGene00004505", "P46502", "WBGene00004503", "Q9XTT9", "WBGene00004506", "O17071", "WBGene00004504", "Q18115", "WBGene00004459", "Q20938", "WBGene00004462", "Q19324", "WBGene00004461", "Q22253", "WBGene00004465", "Q9GZH5", "WBGene00004458", "Q04908", "WBGene00004460", "O61742", "WBGene00004466", "O76577", "WBGene00004467", "Q20058", "WBGene00009445", "O44156", "WBGene00003927", "Q20585", "WBGene00004463", "Q27488", "WBGene00003923", "O61792", "WBGene00004464", "Q09583", "WBGene00003928", "Q23449", "WBGene00004468", "Q9N599", "WBGene00003924", "Q10920", "WBGene00016623", "Q95008", "WBGene00003926", "Q95PZ7", "WBGene00013435", "O17586", "WBGene00003922", "Q95005", "WBGene00003925", "P34286", "WBGene00003952", "P91477", "WBGene00003950" ] }, "reaction_10570789": { "compartment": "compartment_70101", "id": "reaction_10570789", "reactome": "R-CEL-9009308", "name": "STUB1 polyubiquitinates RUNX2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10570782", "species_10502375" ], "products": [ "species_10570784", "species_10530864" ], "modifiers": [ [ "species_10570782", "catalyst" ] ], "additional_components": [ "G5ECY6", "WBGene00000500", "G5EFQ5", "WBGene00004393", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "WBGene00004393", "WBGene00000500", "G5ECY6", "WBGene00000500", "G5EFQ5", "WBGene00004393" ] }, "reaction_10570791": { "compartment": "compartment_70101", "id": "reaction_10570791", "reactome": "R-CEL-9009309", "name": "RUNX2 binds STUB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10570778", "species_10530864" ], "products": [ "species_10570782" ], "modifiers": [], "additional_components": [ "WBGene00004393", "WBGene00000500", "G5ECY6", "WBGene00000500", "G5EFQ5", "WBGene00004393" ] }, "reaction_10568504": { "compartment": "compartment_7660", "id": "reaction_10568504", "reactome": "R-CEL-8939688", "name": "SCF(SKP2) complex binds RUNX2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502340", "species_10567747" ], "products": [ "species_10568502" ], "modifiers": [], "additional_components": [ "Q23457", "WBGene00004320", "G5ECU1", "WBGene00004807", "Q17389", "WBGene00000836", "WBGene00004393", "G5EFQ5", "WBGene00004393", "Q23457", "WBGene00004320", "G5ECU1", "WBGene00004807", "Q17389", "WBGene00000836" ] }, "reaction_10568390": { "compartment": "compartment_7660", "id": "reaction_10568390", "reactome": "R-CEL-8938356", "name": "RMB14 binds RUNX2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10568386", "species_10567747" ], "products": [ "species_10568388" ], "modifiers": [], "additional_components": [ "WBGene00004384", "WBGene00004393", "G5EFQ5", "WBGene00004393", "Q10667", "WBGene00004384" ] }, "reaction_10567757": { "compartment": "compartment_7660", "id": "reaction_10567757", "reactome": "R-CEL-8877941", "name": "RUNX2 binds SMAD1 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10567753", "species_10567751" ], "products": [ "species_10567755" ], "modifiers": [], "additional_components": [ "G5EFQ5", "WBGene00004393", "Q95ZL9", "WBGene00000272", "F5GUE5", "WBGene00000910", "P45896", "WBGene00004857", "Q02330", "WBGene00004856", "P45897", "WBGene00004858", "F5GUE5", "WBGene00000910", "P45896", "WBGene00004857", "Q02330", "WBGene00004856", "P45897", "WBGene00004858", "G5EFQ5", "WBGene00004393", "Q95ZL9", "WBGene00000272" ] }, "reaction_10570776": { "compartment": "compartment_7660", "id": "reaction_10570776", "reactome": "R-CEL-9009282", "name": "CDK1 phosphorylates RUNX2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10567753" ], "products": [ "species_113582", "species_10570692" ], "modifiers": [ [ "species_10511241", "catalyst" ] ], "additional_components": [ "G5EFQ5", "WBGene00004393", "Q95ZL9", "WBGene00000272", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "O45926", "WBGene00000866", "Q10653", "WBGene00000865", "Q9BLB5", "WBGene00000867", "P34556", "WBGene00000405" ] }, "reaction_10569938": { "compartment": "compartment_7660", "id": "reaction_10569938", "reactome": "R-CEL-8954110", "name": "E2F6:TFDP1:EPC1 binds the PRC2 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10569934", "species_10517100" ], "products": [ "species_10569936" ], "modifiers": [], "additional_components": [ "A5HWA8", "WBGene00001162", "Q22703", "WBGene00001061", "G5EC14", "WBGene00007030", "Q9GYS1", "WBGene00003224", "O17514", "WBGene00003220", "P90916", "WBGene00003036", "P90917", "WBGene00004312", "Q9GYS1", "WBGene00003224", "O17514", "WBGene00003220", "P90916", "WBGene00003036", "P90917", "WBGene00004312", "A5HWA8", "WBGene00001162", "Q22703", "WBGene00001061", "G5EC14", "WBGene00007030" ] }, "reaction_10569925": { "compartment": "compartment_7660", "id": "reaction_10569925", "reactome": "R-CEL-8954056", "name": "E2F6 binds TFDP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10532095", "species_10569808" ], "products": [ "species_10569923" ], "modifiers": [], "additional_components": [ "WBGene00001061", "WBGene00001162", "A5HWA8", "WBGene00001162", "Q22703", "WBGene00001061" ] }, "reaction_10569812": { "compartment": "compartment_7660", "id": "reaction_10569812", "reactome": "R-CEL-8953111", "name": "E2F6 binds TFDP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10532093", "species_10569808" ], "products": [ "species_10569810" ], "modifiers": [], "additional_components": [ "WBGene00001061", "WBGene00001162", "A5HWA8", "WBGene00001162", "Q22703", "WBGene00001061" ] }, "reaction_10569940": { "compartment": "compartment_7660", "id": "reaction_10569940", "reactome": "R-CEL-8954117", "name": "E2F6:TFDP1 binds EPC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10569932", "species_10569810" ], "products": [ "species_10569934" ], "modifiers": [], "additional_components": [ "WBGene00007030", "A5HWA8", "WBGene00001162", "Q22703", "WBGene00001061", "A5HWA8", "WBGene00001162", "Q22703", "WBGene00001061", "G5EC14", "WBGene00007030" ] }, "reaction_10570682": { "compartment": "compartment_7660", "id": "reaction_10570682", "reactome": "R-CEL-9007539", "name": "CHEK1 phosphorylates E2F6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10569808" ], "products": [ "species_113582", "species_10570680" ], "modifiers": [ [ "species_10502788", "catalyst" ] ], "additional_components": [ "WBGene00001162", "WBGene00001162", "WBGene00000498" ] }, "reaction_10569855": { "compartment": "compartment_7660", "id": "reaction_10569855", "reactome": "R-CEL-8953115", "name": "E2F6:TFDP1 binds to MGA:MAX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10569851", "species_10569810" ], "products": [ "species_10569853" ], "modifiers": [], "additional_components": [ "Q23622", "WBGene00006555", "Q8TA81", "WBGene00022695", "Q95PX3", "WBGene00006544", "Q9N2K7", "WBGene00006549", "Q9NA55", "WBGene00006559", "Q9NA56", "WBGene00006558", "Q9NAH2", "WBGene00006553", "Q9TZL0", "WBGene00006550", "Q9U2C9", "WBGene00006556", "Q9XVD5", "WBGene00006557", "O45291", "WBGene00006552", "O61764", "WBGene00006551", "Q20257", "WBGene00006547", "Q22289", "WBGene00006546", "Q22292", "WBGene00006545", "Q18711", "WBGene00003511", "A5HWA8", "WBGene00001162", "Q22703", "WBGene00001061", "A5HWA8", "WBGene00001162", "Q22703", "WBGene00001061", "Q23622", "WBGene00006555", "Q8TA81", "WBGene00022695", "Q95PX3", "WBGene00006544", "Q9N2K7", "WBGene00006549", "Q9NA55", "WBGene00006559", "Q9NA56", "WBGene00006558", "Q9NAH2", "WBGene00006553", "Q9TZL0", "WBGene00006550", "Q9U2C9", "WBGene00006556", "Q9XVD5", "WBGene00006557", "O45291", "WBGene00006552", "O61764", "WBGene00006551", "Q20257", "WBGene00006547", "Q22289", "WBGene00006546", "Q22292", "WBGene00006545", "Q18711", "WBGene00003511" ] }, "reaction_10565458": { "compartment": "compartment_7660", "id": "reaction_10565458", "reactome": "R-CEL-8853965", "name": "VENTX disrupts binding of CTNNB1 (beta-catenin) to TCF4 or LEF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10565454", "species_10565450" ], "products": [ "species_10514938", "species_10565456" ], "modifiers": [], "additional_components": [ "Q10666", "WBGene00004077", "O44326", "WBGene00001979", "WBGene00006380", "WBGene00001979", "Q10666", "WBGene00004077", "Q19937", "WBGene00006380" ] }, "reaction_10567123": { "compartment": "compartment_7660", "id": "reaction_10567123", "reactome": "R-CEL-8871265", "name": "YAP1 binds TEAD4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10532633", "species_10542193" ], "products": [ "species_10567121" ], "modifiers": [], "additional_components": [ "WBGene00008748", "WBGene00001208", "Q19849", "WBGene00001208", "Q19404", "WBGene00008748" ] }, "reaction_10542197": { "compartment": "compartment_7660", "id": "reaction_10542197", "reactome": "R-CEL-2032781", "name": "WWTR1 (TAZ) binds TEAD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10542174", "species_10542183" ], "products": [ "species_10542195" ], "modifiers": [], "additional_components": [ "WBGene00008748", "WBGene00001208", "Q19849", "WBGene00001208", "Q19404", "WBGene00008748" ] }, "reaction_10567127": { "compartment": "compartment_7660", "id": "reaction_10567127", "reactome": "R-CEL-8871266", "name": "YAP1 binds TEAD3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10542191", "species_10532633" ], "products": [ "species_10567125" ], "modifiers": [], "additional_components": [ "WBGene00001208", "WBGene00008748", "Q19404", "WBGene00008748", "Q19849", "WBGene00001208" ] }, "reaction_10542187": { "compartment": "compartment_7660", "id": "reaction_10542187", "reactome": "R-CEL-2032775", "name": "YAP1 binds TEAD1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10532633", "species_10542183" ], "products": [ "species_10542185" ], "modifiers": [], "additional_components": [ "WBGene00008748", "WBGene00001208", "Q19849", "WBGene00001208", "Q19404", "WBGene00008748" ] }, "reaction_10542283": { "compartment": "compartment_7660", "id": "reaction_10542283", "reactome": "R-CEL-2032794", "name": "WWTR1 (TAZ), TBX5, and PCAF form a complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10542174", "species_10542202", "species_10542279" ], "products": [ "species_10542281" ], "modifiers": [], "additional_components": [ "WBGene00008748", "WBGene00021636", "Q9U2C9", "WBGene00006556", "Q95PX3", "WBGene00006544", "O61764", "WBGene00006551", "Q9XVD5", "WBGene00006557", "Q9N2K7", "WBGene00006549", "Q20257", "WBGene00006547", "Q9NA55", "WBGene00006559", "Q22289", "WBGene00006546", "Q9NA56", "WBGene00006558", "Q22292", "WBGene00006545", "Q9NAH2", "WBGene00006553", "Q23622", "WBGene00006555", "Q9TZL0", "WBGene00006550", "Q8TA81", "WBGene00022695", "O45291", "WBGene00006552", "Q9U2C9", "WBGene00006556", "Q95PX3", "WBGene00006544", "O61764", "WBGene00006551", "Q9XVD5", "WBGene00006557", "Q9N2K7", "WBGene00006549", "Q20257", "WBGene00006547", "Q9NA55", "WBGene00006559", "Q22289", "WBGene00006546", "Q9NA56", "WBGene00006558", "Q22292", "WBGene00006545", "Q9NAH2", "WBGene00006553", "Q23622", "WBGene00006555", "Q9TZL0", "WBGene00006550", "Q8TA81", "WBGene00022695", "O45291", "WBGene00006552", "Q9N3S7", "WBGene00021636", "Q19404", "WBGene00008748" ] }, "reaction_10567119": { "compartment": "compartment_7660", "id": "reaction_10567119", "reactome": "R-CEL-8871260", "name": "YAP1 binds TEAD2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10542189", "species_10532633" ], "products": [ "species_10567117" ], "modifiers": [], "additional_components": [ "WBGene00001208", "WBGene00008748", "Q19404", "WBGene00008748", "Q19849", "WBGene00001208" ] }, "reaction_10567590": { "compartment": "compartment_7660", "id": "reaction_10567590", "reactome": "R-CEL-8877192", "name": "RUNX1 binds FOXP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10566201", "species_10567586" ], "products": [ "species_10567588" ], "modifiers": [], "additional_components": [ "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "WBGene00001439", "Q86MF0", "WBGene00001439", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393" ] }, "reaction_10568465": { "compartment": "compartment_7660", "id": "reaction_10568465", "reactome": "R-CEL-8938951", "name": "RUNX1 binds PAX5 (BSAP)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10568461", "species_10566201" ], "products": [ "species_10568463" ], "modifiers": [], "additional_components": [ "G5ED14", "WBGene00001204", "G5EDS1", "WBGene00006870", "Q21263", "WBGene00003938", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "G5ED14", "WBGene00001204", "G5EDS1", "WBGene00006870", "Q21263", "WBGene00003938" ] }, "reaction_10568444": { "compartment": "compartment_7660", "id": "reaction_10568444", "reactome": "R-CEL-8938930", "name": "RUNX1 binds ELF2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10568440", "species_10566201" ], "products": [ "species_10568442" ], "modifiers": [], "additional_components": [ "WBGene00016029", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "H2KYY1", "WBGene00016029" ] }, "reaction_10568259": { "compartment": "compartment_7660", "id": "reaction_10568259", "reactome": "R-CEL-8937022", "name": "PRMT6 arginine methylates H3K4me2-Nucleosome at the THBS1 gene promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10568254", "species_77087" ], "products": [ "species_77502", "species_10568256" ], "modifiers": [ [ "species_10568254", "catalyst" ] ], "additional_components": [ "A5JYW9", "WBGene00004117", "G5ECH0", "WBGene00001836", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "P62784", "WBGene00001875", "Q10453", "WBGene00001945", "K7ZUH9", "WBGene00001914", "A5JYW9", "WBGene00004117", "G5ECH0", "WBGene00001836", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "P62784", "WBGene00001875", "Q10453", "WBGene00001945", "K7ZUH9", "WBGene00001914", "A5JYW9", "WBGene00004117", "G5ECH0", "WBGene00001836", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "P62784", "WBGene00001875", "Q10453", "WBGene00001945", "K7ZUH9", "WBGene00001914" ] }, "reaction_10568275": { "compartment": "compartment_7660", "id": "reaction_10568275", "reactome": "R-CEL-8937113", "name": "PRMT6 arginine methylates H3K4me2-Nucleosome at the MIR27A gene promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10568270", "species_77087" ], "products": [ "species_77502", "species_10568272" ], "modifiers": [ [ "species_10568270", "catalyst" ] ], "additional_components": [ "A5JYW9", "WBGene00004117", "G5ECH0", "WBGene00001836", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "P62784", "WBGene00001875", "Q10453", "WBGene00001945", "K7ZUH9", "WBGene00001914", "A5JYW9", "WBGene00004117", "G5ECH0", "WBGene00001836", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "P62784", "WBGene00001875", "Q10453", "WBGene00001945", "K7ZUH9", "WBGene00001914", "A5JYW9", "WBGene00004117", "G5ECH0", "WBGene00001836", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "P62784", "WBGene00001875", "Q10453", "WBGene00001945", "K7ZUH9", "WBGene00001914" ] }, "reaction_10568130": { "compartment": "compartment_7660", "id": "reaction_10568130", "reactome": "R-CEL-8934735", "name": "PRMT1 arginine-methylates RUNX1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10568121" ], "products": [ "species_77502", "species_10568127" ], "modifiers": [ [ "species_10568121", "catalyst" ] ], "additional_components": [ "Q9U2X0", "WBGene00013766", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "Q95ZL9", "WBGene00000272", "Q9U2X0", "WBGene00013766", "G5EFQ5", "WBGene00004393", "Q9U2X0", "WBGene00013766", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393" ] }, "reaction_10568132": { "compartment": "compartment_7660", "id": "reaction_10568132", "reactome": "R-CEL-8934742", "name": "RUNX1 binds PRMT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10566201", "species_10546564" ], "products": [ "species_10568121" ], "modifiers": [], "additional_components": [ "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "WBGene00013766", "Q9U2X0", "WBGene00013766", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393" ] }, "reaction_10568196": { "compartment": "compartment_7660", "id": "reaction_10568196", "reactome": "R-CEL-8936481", "name": "Core MLL complex methylates H3K4Me2-Nucleosome at the ITGA2B gene promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10568187" ], "products": [ "species_77502", "species_10568193" ], "modifiers": [ [ "species_10568187", "catalyst" ] ], "additional_components": [ "Q10661", "WBGene00001088", "G5EFZ3", "WBGene00012458", "Q09309", "WBGene00017683", "Q18221", "WBGene00004782", "G5EGI1", "WBGene00011729", "Q17963", "WBGene00006474", "P34545", "WBGene00000366", "P28515", "WBGene00001249", "Q9N3S7", "WBGene00021636", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "Q9U2X0", "WBGene00013766", "P62784", "WBGene00001875", "Q10453", "WBGene00001945", "K7ZUH9", "WBGene00001914", "Q10661", "WBGene00001088", "G5EFZ3", "WBGene00012458", "Q09309", "WBGene00017683", "Q18221", "WBGene00004782", "G5EGI1", "WBGene00011729", "Q17963", "WBGene00006474", "P34545", "WBGene00000366", "P28515", "WBGene00001249", "Q9N3S7", "WBGene00021636", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "Q9U2X0", "WBGene00013766", "P62784", "WBGene00001875", "K7ZUH9", "WBGene00001914", "Q10453", "WBGene00001945", "Q10661", "WBGene00001088", "G5EFZ3", "WBGene00012458", "Q09309", "WBGene00017683", "Q18221", "WBGene00004782", "G5EGI1", "WBGene00011729", "Q17963", "WBGene00006474", "P34545", "WBGene00000366", "P28515", "WBGene00001249", "Q9N3S7", "WBGene00021636", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "Q9U2X0", "WBGene00013766", "P62784", "WBGene00001875", "Q10453", "WBGene00001945", "K7ZUH9", "WBGene00001914" ] }, "reaction_10568212": { "compartment": "compartment_7660", "id": "reaction_10568212", "reactome": "R-CEL-8936584", "name": "PRMT6 arginine methylates H3K4me2-Nucleosome at the ITGA2B gene promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10568198" ], "products": [ "species_77502", "species_10568209" ], "modifiers": [ [ "species_10568198", "catalyst" ] ], "additional_components": [ "A5JYW9", "WBGene00004117", "G5ECH0", "WBGene00001836", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "P62784", "WBGene00001875", "Q10453", "WBGene00001945", "K7ZUH9", "WBGene00001914", "A5JYW9", "WBGene00004117", "G5ECH0", "WBGene00001836", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "P62784", "WBGene00001875", "Q10453", "WBGene00001945", "K7ZUH9", "WBGene00001914", "A5JYW9", "WBGene00004117", "G5ECH0", "WBGene00001836", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "P62784", "WBGene00001875", "Q10453", "WBGene00001945", "K7ZUH9", "WBGene00001914" ] }, "reaction_10568228": { "compartment": "compartment_7660", "id": "reaction_10568228", "reactome": "R-CEL-8936621", "name": "Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10568223" ], "products": [ "species_77502", "species_10568225" ], "modifiers": [ [ "species_10568223", "catalyst" ] ], "additional_components": [ "Q10661", "WBGene00001088", "G5EFZ3", "WBGene00012458", "Q09309", "WBGene00017683", "Q18221", "WBGene00004782", "G5EGI1", "WBGene00011729", "Q17963", "WBGene00006474", "P34545", "WBGene00000366", "P28515", "WBGene00001249", "Q9N3S7", "WBGene00021636", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "Q9U2X0", "WBGene00013766", "P62784", "WBGene00001875", "Q10453", "WBGene00001945", "K7ZUH9", "WBGene00001914", "Q10661", "WBGene00001088", "G5EFZ3", "WBGene00012458", "Q09309", "WBGene00017683", "Q18221", "WBGene00004782", "G5EGI1", "WBGene00011729", "Q17963", "WBGene00006474", "P34545", "WBGene00000366", "P28515", "WBGene00001249", "Q9N3S7", "WBGene00021636", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "Q9U2X0", "WBGene00013766", "P62784", "WBGene00001875", "K7ZUH9", "WBGene00001914", "Q10453", "WBGene00001945", "Q10661", "WBGene00001088", "G5EFZ3", "WBGene00012458", "Q09309", "WBGene00017683", "Q18221", "WBGene00004782", "G5EGI1", "WBGene00011729", "Q17963", "WBGene00006474", "P34545", "WBGene00000366", "P28515", "WBGene00001249", "Q9N3S7", "WBGene00021636", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "Q9U2X0", "WBGene00013766", "P62784", "WBGene00001875", "Q10453", "WBGene00001945", "K7ZUH9", "WBGene00001914" ] }, "reaction_10568221": { "compartment": "compartment_7660", "id": "reaction_10568221", "reactome": "R-CEL-8936608", "name": "PRMT6 arginine methylates H3K4me2-Nucleosome at the GP1BA gene promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10568216" ], "products": [ "species_77502", "species_10568218" ], "modifiers": [ [ "species_10568216", "catalyst" ] ], "additional_components": [ "A5JYW9", "WBGene00004117", "G5ECH0", "WBGene00001836", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "P62784", "WBGene00001875", "Q10453", "WBGene00001945", "K7ZUH9", "WBGene00001914", "A5JYW9", "WBGene00004117", "G5ECH0", "WBGene00001836", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "P62784", "WBGene00001875", "Q10453", "WBGene00001945", "K7ZUH9", "WBGene00001914", "A5JYW9", "WBGene00004117", "G5ECH0", "WBGene00001836", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "P62784", "WBGene00001875", "Q10453", "WBGene00001945", "K7ZUH9", "WBGene00001914" ] }, "reaction_10568252": { "compartment": "compartment_7660", "id": "reaction_10568252", "reactome": "R-CEL-8937016", "name": "Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10568247" ], "products": [ "species_77502", "species_10568249" ], "modifiers": [ [ "species_10568247", "catalyst" ] ], "additional_components": [ "Q10661", "WBGene00001088", "G5EFZ3", "WBGene00012458", "Q09309", "WBGene00017683", "Q18221", "WBGene00004782", "G5EGI1", "WBGene00011729", "Q17963", "WBGene00006474", "P34545", "WBGene00000366", "P28515", "WBGene00001249", "Q9N3S7", "WBGene00021636", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "Q9U2X0", "WBGene00013766", "P62784", "WBGene00001875", "Q10453", "WBGene00001945", "K7ZUH9", "WBGene00001914", "Q10661", "WBGene00001088", "G5EFZ3", "WBGene00012458", "Q09309", "WBGene00017683", "Q18221", "WBGene00004782", "G5EGI1", "WBGene00011729", "Q17963", "WBGene00006474", "P34545", "WBGene00000366", "P28515", "WBGene00001249", "Q9N3S7", "WBGene00021636", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "Q9U2X0", "WBGene00013766", "P62784", "WBGene00001875", "K7ZUH9", "WBGene00001914", "Q10453", "WBGene00001945", "Q10661", "WBGene00001088", "G5EFZ3", "WBGene00012458", "Q09309", "WBGene00017683", "Q18221", "WBGene00004782", "G5EGI1", "WBGene00011729", "Q17963", "WBGene00006474", "P34545", "WBGene00000366", "P28515", "WBGene00001249", "Q9N3S7", "WBGene00021636", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "Q9U2X0", "WBGene00013766", "P62784", "WBGene00001875", "Q10453", "WBGene00001945", "K7ZUH9", "WBGene00001914" ] }, "reaction_10568268": { "compartment": "compartment_7660", "id": "reaction_10568268", "reactome": "R-CEL-8937050", "name": "Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10568263" ], "products": [ "species_77502", "species_10568265" ], "modifiers": [ [ "species_10568263", "catalyst" ] ], "additional_components": [ "Q10661", "WBGene00001088", "G5EFZ3", "WBGene00012458", "Q09309", "WBGene00017683", "Q18221", "WBGene00004782", "G5EGI1", "WBGene00011729", "Q17963", "WBGene00006474", "P34545", "WBGene00000366", "P28515", "WBGene00001249", "Q9N3S7", "WBGene00021636", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "Q9U2X0", "WBGene00013766", "P62784", "WBGene00001875", "Q10453", "WBGene00001945", "K7ZUH9", "WBGene00001914", "Q10661", "WBGene00001088", "G5EFZ3", "WBGene00012458", "Q09309", "WBGene00017683", "Q18221", "WBGene00004782", "G5EGI1", "WBGene00011729", "Q17963", "WBGene00006474", "P34545", "WBGene00000366", "P28515", "WBGene00001249", "Q9N3S7", "WBGene00021636", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "Q9U2X0", "WBGene00013766", "P62784", "WBGene00001875", "K7ZUH9", "WBGene00001914", "Q10453", "WBGene00001945", "Q10661", "WBGene00001088", "G5EFZ3", "WBGene00012458", "Q09309", "WBGene00017683", "Q18221", "WBGene00004782", "G5EGI1", "WBGene00011729", "Q17963", "WBGene00006474", "P34545", "WBGene00000366", "P28515", "WBGene00001249", "Q9N3S7", "WBGene00021636", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "Q9U2X0", "WBGene00013766", "P62784", "WBGene00001875", "Q10453", "WBGene00001945", "K7ZUH9", "WBGene00001914" ] }, "reaction_10567792": { "compartment": "compartment_7660", "id": "reaction_10567792", "reactome": "R-CEL-8878050", "name": "HIPK2 phosphorylates RUNX1 and EP300", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10567776" ], "products": [ "species_113582", "species_10567789" ], "modifiers": [ [ "species_10549016", "catalyst" ] ], "additional_components": [ "P34545", "WBGene00000366", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "P34545", "WBGene00000366", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "WBGene00001994" ] }, "reaction_10567794": { "compartment": "compartment_7660", "id": "reaction_10567794", "reactome": "R-CEL-8878054", "name": "HIPK2 phosphorylates RUNX1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10566201" ], "products": [ "species_113582", "species_10567787" ], "modifiers": [ [ "species_10549016", "catalyst" ] ], "additional_components": [ "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "WBGene00001994" ] }, "reaction_10567796": { "compartment": "compartment_7660", "id": "reaction_10567796", "reactome": "R-CEL-8878056", "name": "RUNX1:CBFB binds EP300", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10566201", "species_10532228" ], "products": [ "species_10567776" ], "modifiers": [], "additional_components": [ "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "WBGene00000366", "P34545", "WBGene00000366", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393" ] }, "reaction_10568377": { "compartment": "compartment_7660", "id": "reaction_10568377", "reactome": "R-CEL-8938217", "name": "RUNX1 binds the SWI/SNF complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546652", "species_10566201" ], "products": [ "species_10568375" ], "modifiers": [], "additional_components": [ "H8ESF3", "WBGene00004203", "Q21831", "WBGene00011111", "G5EF53", "WBGene00004204", "P91094", "WBGene00004106", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "H8ESF3", "WBGene00004203", "Q21831", "WBGene00011111", "G5EF53", "WBGene00004204", "P91094", "WBGene00004106" ] }, "reaction_10570134": { "compartment": "compartment_7660", "id": "reaction_10570134", "reactome": "R-CEL-8956639", "name": "RUNX1 binds YAP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10532633", "species_10566201" ], "products": [ "species_10570132" ], "modifiers": [ [ "species_10555896", "inhibitor" ] ], "additional_components": [ "WBGene00008748", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "Q19404", "WBGene00008748", "WBGene00000018" ] }, "reaction_10570141": { "compartment": "compartment_7660", "id": "reaction_10570141", "reactome": "R-CEL-8956659", "name": "ABL1 phosphorylates YAP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10532633" ], "products": [ "species_113582", "species_10570138" ], "modifiers": [ [ "species_10555896", "catalyst" ] ], "additional_components": [ "WBGene00008748", "WBGene00008748", "WBGene00000018" ] }, "reaction_10568381": { "compartment": "compartment_7660", "id": "reaction_10568381", "reactome": "R-CEL-8938231", "name": "RUNX1:CBFB binds CREBBP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10566201", "species_10532226" ], "products": [ "species_10568379" ], "modifiers": [], "additional_components": [ "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "WBGene00000366", "P34545", "WBGene00000366", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393" ] }, "reaction_10552368": { "compartment": "compartment_7660", "id": "reaction_10552368", "reactome": "R-CEL-5444523", "name": "Formation of MSH1:PMS2 Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10551625", "species_10551620" ], "products": [ "species_10551627" ], "modifiers": [], "additional_components": [ "WBGene00004064", "WBGene00003373", "Q9XU10", "WBGene00003373", "G5EFG5", "WBGene00004064" ] }, "reaction_10551667": { "compartment": "compartment_7660", "id": "reaction_10551667", "reactome": "R-CEL-5358597", "name": "EXO1 interacts with MSH2:MSH6 (MutSalpha) and MLH1:PMS2 (MutLalpha)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10551663", "species_10551647" ], "products": [ "species_10551665" ], "modifiers": [], "additional_components": [ "WBGene00009731", "Q9TXR4", "WBGene00003418", "Q9N3T8", "WBGene00003422", "species_29358", "Q9XU10", "WBGene00003373", "G5EFG5", "WBGene00004064", "O02115", "WBGene00003955", "Q9TXR4", "WBGene00003418", "Q9N3T8", "WBGene00003422", "species_29358", "Q9XU10", "WBGene00003373", "G5EFG5", "WBGene00004064", "O02115", "WBGene00003955", "O62245", "WBGene00009731" ] }, "reaction_10551650": { "compartment": "compartment_7660", "id": "reaction_10551650", "reactome": "R-CEL-5358518", "name": "MLH1:PMS2 makes single strand incision near 1-2 base mismatch", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10551643" ], "products": [ "species_10551647" ], "modifiers": [ [ "species_10551643", "catalyst" ] ], "additional_components": [ "Q9TXR4", "WBGene00003418", "Q9N3T8", "WBGene00003422", "species_29358", "Q9XU10", "WBGene00003373", "G5EFG5", "WBGene00004064", "O02115", "WBGene00003955", "Q9TXR4", "WBGene00003418", "Q9N3T8", "WBGene00003422", "species_29358", "Q9XU10", "WBGene00003373", "G5EFG5", "WBGene00004064", "O02115", "WBGene00003955", "Q9TXR4", "WBGene00003418", "Q9N3T8", "WBGene00003422", "species_29358", "Q9XU10", "WBGene00003373", "G5EFG5", "WBGene00004064", "O02115", "WBGene00003955" ] }, "reaction_10551669": { "compartment": "compartment_7660", "id": "reaction_10551669", "reactome": "R-CEL-5358912", "name": "MSH2:MSH6 exchanges ADP for ATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10551654" ], "products": [ "species_113582", "species_10551641" ], "modifiers": [], "additional_components": [ "Q9TXR4", "WBGene00003418", "Q9N3T8", "WBGene00003422", "species_113582", "Q9TXR4", "WBGene00003418", "Q9N3T8", "WBGene00003422", "species_29358" ] }, "reaction_10551656": { "compartment": "compartment_7660", "id": "reaction_10551656", "reactome": "R-CEL-5358525", "name": "MSH2:MSH6 binds 1 base mismatch or 1-2 base insertion/deletion loop", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10551652", "species_5358514" ], "products": [ "species_10551654" ], "modifiers": [], "additional_components": [ "Q9TXR4", "WBGene00003418", "Q9N3T8", "WBGene00003422", "species_113582", "Q9TXR4", "WBGene00003418", "Q9N3T8", "WBGene00003422", "species_113582" ] }, "reaction_10551645": { "compartment": "compartment_7660", "id": "reaction_10551645", "reactome": "R-CEL-5358510", "name": "MSH2:MSH6 recruits MLH1:PMS2 to mismatch and interacts with PCNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502653", "species_10551627", "species_10551641" ], "products": [ "species_10551643" ], "modifiers": [], "additional_components": [ "O02115", "WBGene00003955", "Q9XU10", "WBGene00003373", "G5EFG5", "WBGene00004064", "Q9TXR4", "WBGene00003418", "Q9N3T8", "WBGene00003422", "species_29358", "Q9TXR4", "WBGene00003418", "Q9N3T8", "WBGene00003422", "species_29358", "Q9XU10", "WBGene00003373", "G5EFG5", "WBGene00004064", "O02115", "WBGene00003955" ] }, "reaction_10552366": { "compartment": "compartment_7660", "id": "reaction_10552366", "reactome": "R-CEL-5444516", "name": "Formation of MSH2:MSH6 Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113582", "species_10551637", "species_10551632" ], "products": [ "species_10551652" ], "modifiers": [], "additional_components": [ "WBGene00003422", "WBGene00003418", "Q9TXR4", "WBGene00003418", "Q9N3T8", "WBGene00003422", "species_113582" ] }, "reaction_10521473": { "compartment": "compartment_70101", "id": "reaction_10521473", "reactome": "R-CEL-399951", "name": "Phosphorylation of CRMPs by GSK3beta", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10521396" ], "products": [ "species_10521470", "species_29370" ], "modifiers": [ [ "species_10513574", "catalyst" ] ], "additional_components": [ "O45657", "WBGene00004048", "U4PRY7", "WBGene00004047", "G5ECH7", "WBGene00000407", "Q22695", "WBGene00011955", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q18677", "WBGene00000964", "Q21773", "WBGene00000963", "Q01630", "WBGene00006769", "Q95XP4", "WBGene00003111", "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "Q95XP4", "WBGene00003111", "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "O45657", "WBGene00004048", "U4PRY7", "WBGene00004047", "Q18677", "WBGene00000964", "Q21773", "WBGene00000963", "Q01630", "WBGene00006769", "G5ECH7", "WBGene00000407", "Q22695", "WBGene00011955", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q9U2Q9", "WBGene00001746", "Q09595", "WBGene00010991", "Q93372", "WBGene00010991" ] }, "reaction_10521399": { "compartment": "compartment_70101", "id": "reaction_10521399", "reactome": "R-CEL-399944", "name": "Phosphorylation of CRMPs by Cdk5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10521323", "species_113592", "species_10521345" ], "products": [ "species_29370", "species_10521396" ], "modifiers": [ [ "species_10521345", "catalyst" ] ], "additional_components": [ "Q18677", "WBGene00000964", "Q21773", "WBGene00000963", "Q01630", "WBGene00006769", "Q95XP4", "WBGene00003111", "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "O45657", "WBGene00004048", "U4PRY7", "WBGene00004047", "G5ECH7", "WBGene00000407", "Q22695", "WBGene00011955", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "O45657", "WBGene00004048", "U4PRY7", "WBGene00004047", "G5ECH7", "WBGene00000407", "Q22695", "WBGene00011955", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q18677", "WBGene00000964", "Q21773", "WBGene00000963", "Q01630", "WBGene00006769", "Q95XP4", "WBGene00003111", "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "Q95XP4", "WBGene00003111", "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "O45657", "WBGene00004048", "U4PRY7", "WBGene00004047", "G5ECH7", "WBGene00000407", "Q22695", "WBGene00011955", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635" ] }, "reaction_10521435": { "compartment": "compartment_70101", "id": "reaction_10521435", "reactome": "R-CEL-399947", "name": "Tyrosine phosphorylation of CRMPs by Fes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10521323", "species_113592", "species_10521204" ], "products": [ "species_29370", "species_10521432" ], "modifiers": [ [ "species_10516270", "catalyst" ] ], "additional_components": [ "Q18677", "WBGene00000964", "Q21773", "WBGene00000963", "Q01630", "WBGene00006769", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "U4PRY7", "WBGene00004047", "O45657", "WBGene00004048", "Q95XP4", "WBGene00003111", "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "O01325", "WBGene00009160", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "U4PRY7", "WBGene00004047", "O45657", "WBGene00004048", "Q95XP4", "WBGene00003111", "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "O01325", "WBGene00009160", "Q21773", "WBGene00000963", "Q01630", "WBGene00006769", "Q18677", "WBGene00000964", "WBGene00009160" ] }, "reaction_10503744": { "compartment": "compartment_70101", "id": "reaction_10503744", "reactome": "R-CEL-71130", "name": "q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_71129", "species_73473" ], "products": [ "species_29870", "species_29360" ], "modifiers": [ [ "species_10503741", "catalyst" ] ], "additional_components": [ "Q9XVJ3", "WBGene00011398" ] }, "reaction_10503734": { "compartment": "compartment_70101", "id": "reaction_10503734", "reactome": "R-CEL-71118", "name": "PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29870", "species_29502", "species_29368" ], "products": [ "species_71112", "species_29506" ], "modifiers": [ [ "species_10503731", "catalyst" ] ], "additional_components": [ "P90925", "WBGene00000240", "species_113531" ] }, "reaction_10528409": { "compartment": "compartment_70101", "id": "reaction_10528409", "reactome": "R-CEL-893593", "name": "phenylalanine + pyruvate => 3-(indol-3-yl)pyruvate + alanine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29502", "species_29398" ], "products": [ "species_29432", "species_893599" ], "modifiers": [ [ "species_10528406", "catalyst" ] ], "additional_components": [ "Q9XX97", "WBGene00009232", "Q8MP09", "WBGene00010984" ] }, "reaction_10503754": { "compartment": "compartment_70101", "id": "reaction_10503754", "reactome": "R-CEL-71146", "name": "4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71112" ], "products": [ "species_29356", "species_71129" ], "modifiers": [ [ "species_10503751", "catalyst" ] ], "additional_components": [ "Q9TZH6", "WBGene00020397" ] }, "reaction_10507618": { "compartment": "compartment_17951", "id": "reaction_10507618", "reactome": "R-CEL-76031", "name": "2 H2O2 => O2 + 2 H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113575" ], "products": [ "species_113535", "species_141343" ], "modifiers": [ [ "species_10507615", "catalyst" ] ], "additional_components": [ "species_71185", "species_29364", "Q8MYL7", "WBGene00013220" ] }, "reaction_10548068": { "compartment": "compartment_17927", "id": "reaction_10548068", "reactome": "R-CEL-3777112", "name": "SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_3341308", "species_163953" ], "products": [ "species_189481", "species_189461" ], "modifiers": [ [ "species_10548065", "catalyst" ] ], "additional_components": [ "species_209799", "species_216785", "P34697", "WBGene00004930", "Q27538", "WBGene00007036" ] }, "reaction_10547432": { "compartment": "compartment_5460", "id": "reaction_10547432", "reactome": "R-CEL-3323079", "name": "GSR catalyzes glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113529", "species_1655882", "species_113600" ], "products": [ "species_113563", "species_1655887" ], "modifiers": [ [ "species_10547429", "catalyst" ] ], "additional_components": [ "Q93379", "WBGene00008117", "species_113596" ] }, "reaction_10549770": { "compartment": "compartment_17963", "id": "reaction_10549770", "reactome": "R-CEL-4837364", "name": "Secretion of SOD3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10549768" ], "products": [ "species_10547194" ], "modifiers": [], "additional_components": [ "P34697", "WBGene00004930", "species_216785", "species_209799", "species_216785", "P34697", "WBGene00004930", "species_209799" ] }, "reaction_10547467": { "compartment": "compartment_70101", "id": "reaction_10547467", "reactome": "R-CEL-3343700", "name": "PRDX6:GSTP1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29450", "species_29408" ], "products": [ "species_29356", "species_111745" ], "modifiers": [ [ "species_10547464", "catalyst" ] ], "additional_components": [ "Q8MXT1", "WBGene00021401", "P10299", "WBGene00001749" ] }, "reaction_10547212": { "compartment": "compartment_70101", "id": "reaction_10547212", "reactome": "R-CEL-3299691", "name": "SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_1222424" ], "products": [ "species_29368", "species_29408" ], "modifiers": [ [ "species_10547209", "catalyst" ] ], "additional_components": [ "species_216785", "species_209799", "P34697", "WBGene00004930", "Q27538", "WBGene00007036" ] }, "reaction_10547438": { "compartment": "compartment_70616", "id": "reaction_10547438", "reactome": "R-CEL-3341294", "name": "Superoxide reduces cytochrome c", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10510159", "species_3341308" ], "products": [ "species_10510157", "species_189461" ], "modifiers": [], "additional_components": [ "CHEBI:38574", "P19974", "WBGene00017121", "Q23240", "WBGene00013854", "CHEBI:38573", "P19974", "WBGene00017121", "Q23240", "WBGene00013854" ] }, "reaction_10547186": { "compartment": "compartment_5460", "id": "reaction_10547186", "reactome": "R-CEL-3299680", "name": "SOD2 catalyzes 2H+ + 2O2.- => O2 + H2O2 (mitochondrial matrix)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113529", "species_3299683" ], "products": [ "species_113533", "species_1614617" ], "modifiers": [ [ "species_10547183", "catalyst" ] ], "additional_components": [ "species_266099", "P31161", "WBGene00004931" ] }, "reaction_10547411": { "compartment": "compartment_5460", "id": "reaction_10547411", "reactome": "R-CEL-3322995", "name": "PRDX3,5 catalyze TXN2 reduced + H2O2 => TXN2 oxidized + 2H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10547396", "species_1614617" ], "products": [ "species_10547399", "species_113521" ], "modifiers": [ [ "species_10547408", "catalyst" ] ], "additional_components": [ "WBGene00007099", "WBGene00007099", "Q21824", "WBGene00011110" ] }, "reaction_10557597": { "compartment": "compartment_5460", "id": "reaction_10557597", "reactome": "R-CEL-5696197", "name": "NUDT2 hydrolyses GP4G to GTP, GMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5696199", "species_113521" ], "products": [ "species_5696194", "species_113573" ], "modifiers": [ [ "species_10557594", "catalyst" ] ], "additional_components": [ "WBGene00003581" ] }, "reaction_10547197": { "compartment": "compartment_984", "id": "reaction_10547197", "reactome": "R-CEL-3299682", "name": "SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_3299686" ], "products": [ "species_351629", "species_352327" ], "modifiers": [ [ "species_10547194", "catalyst" ] ], "additional_components": [ "species_216785", "P34697", "WBGene00004930", "species_209799" ] }, "reaction_10547423": { "compartment": "compartment_5460", "id": "reaction_10547423", "reactome": "R-CEL-3323050", "name": "TXNRD2 catalyzes the reduction of TXN2 by NADPH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113529", "species_10547399", "species_113600" ], "products": [ "species_113563", "species_10547396" ], "modifiers": [ [ "species_10547420", "catalyst" ] ], "additional_components": [ "WBGene00007099", "WBGene00007099", "P30635", "WBGene00014028", "species_113596" ] }, "reaction_10502803": { "compartment": "compartment_7660", "id": "reaction_10502803", "reactome": "R-CEL-69608", "name": "Phosphorylation of Cdc25A at Ser-123 by Chk2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10502759" ], "products": [ "species_113582", "species_10502781" ], "modifiers": [ [ "species_10502800", "catalyst" ] ], "additional_components": [ "WBGene00000389", "WBGene00000389", "WBGene00000499" ] }, "reaction_10502779": { "compartment": "compartment_70101", "id": "reaction_10502779", "reactome": "R-CEL-69600", "name": "Proteolytic degradation of ubiquitinated-Cdc25A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502777" ], "products": [ "species_10502375" ], "modifiers": [ [ "species_10502572", "catalyst" ] ], "additional_components": [ "Q21762", "WBGene00000389", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "P91477", "WBGene00003950", "Q95PZ7", "WBGene00013435", "Q18115", "WBGene00004459", "O62102", "WBGene00003948", "O17071", "WBGene00004504", "Q10920", "WBGene00016623", "P34286", "WBGene00003952", "Q9XTT9", "WBGene00004506", "Q23449", "WBGene00004468", "Q95005", "WBGene00003925", "P46502", "WBGene00004503", "O61792", "WBGene00004464", "O17586", "WBGene00003922", "O76371", "WBGene00004505", "Q20585", "WBGene00004463", "Q95008", "WBGene00003926", "Q18787", "WBGene00004501", "Q20058", "WBGene00009445", "Q9N599", "WBGene00003924", "O16368", "WBGene00004502", "O61742", "WBGene00004466", "Q09583", "WBGene00003928", "Q966I8", "WBGene00003947", "Q04908", "WBGene00004460", "Q9XUV0", "WBGene00003951", "Q27488", "WBGene00003923", "Q9GZH5", "WBGene00004458", "O44156", "WBGene00003927", "Q22253", "WBGene00004465", "O76577", "WBGene00004467", "P90868", "WBGene00003953", "Q19324", "WBGene00004461", "Q17971", "WBGene00007588", "Q23237", "WBGene00003949", "Q20938", "WBGene00004462" ] }, "reaction_10557688": { "compartment": "compartment_7660", "id": "reaction_10557688", "reactome": "R-CEL-5696655", "name": "PARP1 or PARP2 PARylates DDB2 and autoPARylates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10557686", "species_427523" ], "products": [ "species_427497", "species_10556156" ], "modifiers": [], "additional_components": [ "Q21554", "WBGene00010890", "Q23457", "WBGene00004320", "Q17392", "WBGene00000839", "P30644", "WBGene00011145", "Q23451", "WBGene00013924", "Q9N4C3", "WBGene00022296", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "Q23457", "WBGene00004320", "Q17392", "WBGene00000839", "Q21554", "WBGene00010890", "P30644", "WBGene00011145", "Q23451", "WBGene00013924", "Q9N4C3", "WBGene00022296", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725" ] }, "reaction_10556733": { "compartment": "compartment_7660", "id": "reaction_10556733", "reactome": "R-CEL-5691004", "name": "XPC binds RAD23 and CETN2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10549311", "species_10556067", "species_10549280" ], "products": [ "species_10556731" ], "modifiers": [], "additional_components": [ "WBGene00022296", "WBGene00013924", "WBGene00011145", "P30644", "WBGene00011145", "Q23451", "WBGene00013924", "Q9N4C3", "WBGene00022296" ] }, "reaction_10556781": { "compartment": "compartment_7660", "id": "reaction_10556781", "reactome": "R-CEL-5691006", "name": "XPC:RAD23:CETN2 and UV-DDB bind distorted dsDNA site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10556731", "species_10556777", "species_5688114" ], "products": [ "species_10556779", "species_10556775" ], "modifiers": [], "additional_components": [ "P30644", "WBGene00011145", "Q23451", "WBGene00013924", "Q9N4C3", "WBGene00022296", "Q21554", "WBGene00010890", "Q23457", "WBGene00004320", "Q17392", "WBGene00000839", "Q9GS00", "WBGene00000813", "Q9N359", "WBGene00000816", "P91001", "WBGene00000817", "O01422", "WBGene00000814", "Q9N425", "WBGene00000815", "Q95PZ0", "WBGene00000818", "Q21554", "WBGene00010890", "Q23457", "WBGene00004320", "Q17392", "WBGene00000839", "P30644", "WBGene00011145", "Q23451", "WBGene00013924", "Q9N4C3", "WBGene00022296", "Q9GS00", "WBGene00000813", "Q9N359", "WBGene00000816", "P91001", "WBGene00000817", "O01422", "WBGene00000814", "Q9N425", "WBGene00000815", "Q95PZ0", "WBGene00000818" ] }, "reaction_10557965": { "compartment": "compartment_7660", "id": "reaction_10557965", "reactome": "R-CEL-6782943", "name": "UV-DDB ubiquitinates XPC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502318", "species_10556779" ], "products": [ "species_10557684" ], "modifiers": [ [ "species_10556779", "catalyst" ] ], "additional_components": [ "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "Q21554", "WBGene00010890", "Q23457", "WBGene00004320", "Q17392", "WBGene00000839", "P30644", "WBGene00011145", "Q23451", "WBGene00013924", "Q9N4C3", "WBGene00022296", "Q21554", "WBGene00010890", "Q23457", "WBGene00004320", "Q17392", "WBGene00000839", "P30644", "WBGene00011145", "Q23451", "WBGene00013924", "Q9N4C3", "WBGene00022296", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "Q21554", "WBGene00010890", "Q23457", "WBGene00004320", "Q17392", "WBGene00000839", "P30644", "WBGene00011145", "Q23451", "WBGene00013924", "Q9N4C3", "WBGene00022296" ] }, "reaction_10537696": { "compartment": "compartment_876", "id": "reaction_10537696", "reactome": "R-CEL-1855213", "name": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_994170" ], "products": [ "species_29372", "species_994123" ], "modifiers": [ [ "species_10537691", "catalyst" ] ], "additional_components": [ "WBGene00007620" ] }, "reaction_10537745": { "compartment": "compartment_876", "id": "reaction_10537745", "reactome": "R-CEL-1855221", "name": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_179856" ], "products": [ "species_114520", "species_114519" ], "modifiers": [ [ "species_10537742", "catalyst" ] ], "additional_components": [ "G5EFI8", "WBGene00004036", "species_74016", "Q22070", "WBGene00004038" ] }, "reaction_10537729": { "compartment": "compartment_70101", "id": "reaction_10537729", "reactome": "R-CEL-1855218", "name": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_994170" ], "products": [ "species_29372", "species_994123" ], "modifiers": [ [ "species_10537603", "catalyst" ] ], "additional_components": [ "O17590", "WBGene00007620", "P34370", "WBGene00086546", "G5ECL2", "WBGene00006763" ] }, "reaction_10537619": { "compartment": "compartment_70101", "id": "reaction_10537619", "reactome": "R-CEL-1855177", "name": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_179856" ], "products": [ "species_114520", "species_114519" ], "modifiers": [ [ "species_10537616", "catalyst" ] ], "additional_components": [ "species_74016", "G5EBH0", "WBGene00001177" ] }, "reaction_10537513": { "compartment": "compartment_70101", "id": "reaction_10537513", "reactome": "R-CEL-1855153", "name": "I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by ITPKA/B/C in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_114520" ], "products": [ "species_29370", "species_994170" ], "modifiers": [ [ "species_10537510", "catalyst" ] ], "additional_components": [ "species_74016", "Q95Q62", "WBGene00002979", "Q11083", "WBGene00020378", "P04630", "WBGene00000285", "G5EF37", "WBGene00003934", "A0A2C9C3L3", "WBGene00020378", "Q18136", "WBGene00006861", "Q09665", "WBGene00006583", "O02159", "WBGene00020378", "G5EDZ8", "WBGene00000288", "Q94288", "WBGene00000287", "Q09980", "WBGene00017394", "O16305", "WBGene00000552", "G5EEG0", "WBGene00000286" ] }, "reaction_10537723": { "compartment": "compartment_12045", "id": "reaction_10537723", "reactome": "R-CEL-1855214", "name": "PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2023856", "species_29356" ], "products": [ "species_114520", "species_1500596" ], "modifiers": [ [ "species_10537720", "catalyst" ] ], "additional_components": [ "Q8I4C7", "WBGene00020256", "H2KZ05", "WBGene00020256", "O17405", "WBGene00017316", "Q19056", "WBGene00020256", "species_74016" ] }, "reaction_10537677": { "compartment": "compartment_70101", "id": "reaction_10537677", "reactome": "R-CEL-1855205", "name": "I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_994170" ], "products": [ "species_29372", "species_114520" ], "modifiers": [ [ "species_10537674", "catalyst" ] ], "additional_components": [ "species_114632", "G5EE01", "WBGene00000913" ] }, "reaction_10572147": { "compartment": "compartment_12045", "id": "reaction_10572147", "reactome": "R-CEL-9614271", "name": "Autocleavage of ADGRG6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10572138" ], "products": [ "species_10572144" ], "modifiers": [ [ "species_10572138", "catalyst" ] ], "additional_components": [ "WBGene00017947", "Q19930", "WBGene00017947", "WBGene00017947" ] }, "reaction_10572149": { "compartment": "compartment_876", "id": "reaction_10572149", "reactome": "R-CEL-9614273", "name": "ADGRG heterodimer translocates to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10572144" ], "products": [ "species_10572144" ], "modifiers": [], "additional_components": [ "Q19930", "WBGene00017947", "Q19930", "WBGene00017947" ] }, "reaction_10519185": { "compartment": "compartment_984", "id": "reaction_10519185", "reactome": "R-CEL-375160", "name": "NCAM1 binds to ATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_114570", "species_10518758" ], "products": [ "species_10519183" ], "modifiers": [], "additional_components": [ "WBGene00004372", "C6KRM7", "WBGene00004372", "species_29358" ] }, "reaction_10519181": { "compartment": "compartment_984", "id": "reaction_10519181", "reactome": "R-CEL-375151", "name": "Interaction of NCAM1 with collagens", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10519177", "species_10518758" ], "products": [ "species_10519179" ], "modifiers": [], "additional_components": [ "Q9N4U2", "WBGene00000647", "O76368", "WBGene00000674", "Q09457", "WBGene00000251", "P17140", "WBGene00002280", "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689", "WBGene00004372", "C6KRM7", "WBGene00004372", "Q9N4U2", "WBGene00000647", "O76368", "WBGene00000674", "Q09457", "WBGene00000251", "P17140", "WBGene00002280", "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689" ] }, "reaction_10520993": { "compartment": "compartment_70101", "id": "reaction_10520993", "reactome": "R-CEL-392054", "name": "NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10512175", "species_29438" ], "products": [ "species_29420", "species_10511481" ], "modifiers": [ [ "species_10520988", "catalyst" ] ], "additional_components": [ "species_29420", "P22981", "WBGene00002335", "species_29438", "P22981", "WBGene00002335", "E0AHA7", "WBGene00006803", "G5EFW3", "WBGene00004855", "Q21408", "WBGene00004951", "Q7YZG5", "WBGene00021702", "C6KRM7", "WBGene00004372", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "P29355", "WBGene00004774", "Q9N5D3", "WBGene00004947", "Q95YD4", "WBGene00002213" ] }, "reaction_10520984": { "compartment": "compartment_70101", "id": "reaction_10520984", "reactome": "R-CEL-392051", "name": "Recruitment of Grb2 to pFAK:NCAM1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10506871", "species_10520978" ], "products": [ "species_10520982" ], "modifiers": [], "additional_components": [ "WBGene00004774", "E0AHA7", "WBGene00006803", "G5EFW3", "WBGene00004855", "Q21408", "WBGene00004951", "Q7YZG5", "WBGene00021702", "C6KRM7", "WBGene00004372", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q95YD4", "WBGene00002213", "E0AHA7", "WBGene00006803", "G5EFW3", "WBGene00004855", "Q21408", "WBGene00004951", "Q7YZG5", "WBGene00021702", "C6KRM7", "WBGene00004372", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "P29355", "WBGene00004774", "Q95YD4", "WBGene00002213" ] }, "reaction_10520990": { "compartment": "compartment_70101", "id": "reaction_10520990", "reactome": "R-CEL-392053", "name": "SOS binds Grb2 bound to pFAK:NCAM1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10506876", "species_10520982" ], "products": [ "species_10520988" ], "modifiers": [], "additional_components": [ "WBGene00004947", "E0AHA7", "WBGene00006803", "G5EFW3", "WBGene00004855", "Q21408", "WBGene00004951", "Q7YZG5", "WBGene00021702", "C6KRM7", "WBGene00004372", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "P29355", "WBGene00004774", "Q95YD4", "WBGene00002213", "E0AHA7", "WBGene00006803", "G5EFW3", "WBGene00004855", "Q21408", "WBGene00004951", "Q7YZG5", "WBGene00021702", "C6KRM7", "WBGene00004372", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "P29355", "WBGene00004774", "Q9N5D3", "WBGene00004947", "Q95YD4", "WBGene00002213" ] }, "reaction_10570819": { "compartment": "compartment_984", "id": "reaction_10570819", "reactome": "R-CEL-9010815", "name": "SLITs bind keratan sulfate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10519315", "species_2299699" ], "products": [ "species_10570817" ], "modifiers": [], "additional_components": [ "WBGene00004854", "species_2299699", "G5EFX6", "WBGene00004854" ] }, "reaction_10523182": { "compartment": "compartment_876", "id": "reaction_10523182", "reactome": "R-CEL-428518", "name": "Glypican-1 (GPC1) binds SLIT2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10523178", "species_10519315" ], "products": [ "species_10523180" ], "modifiers": [], "additional_components": [ "G5EGU4", "WBGene00001687", "Q18530", "WBGene00003056", "CHEBI:17421", "WBGene00004854", "G5EFX6", "WBGene00004854", "G5EGU4", "WBGene00001687", "Q18530", "WBGene00003056", "CHEBI:17421" ] }, "reaction_10571295": { "compartment": "compartment_984", "id": "reaction_10571295", "reactome": "R-CEL-9014812", "name": "ROBOs bind keratan sulfate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10523160", "species_2299699" ], "products": [ "species_10571293" ], "modifiers": [], "additional_components": [ "WBGene00004732", "species_2299699", "Q53U87", "WBGene00004732" ] }, "reaction_10521289": { "compartment": "compartment_70101", "id": "reaction_10521289", "reactome": "R-CEL-399939", "name": "Autophosphorylation of PAK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10521208" ], "products": [ "species_29370", "species_10521286" ], "modifiers": [ [ "species_10521208", "catalyst" ] ], "additional_components": [ "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "species_29438", "Q03206", "ced-10", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "U4PRY7", "WBGene00004047", "O45657", "WBGene00004048", "Q95XP4", "WBGene00003111", "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "O01325", "WBGene00009160", "Q17850", "WBGene00003911", "G5EGQ3", "WBGene00003144", "species_29438", "Q03206", "ced-10", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "U4PRY7", "WBGene00004047", "O45657", "WBGene00004048", "Q95XP4", "WBGene00003111", "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "O01325", "WBGene00009160", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "species_29438", "Q03206", "ced-10", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "U4PRY7", "WBGene00004047", "O45657", "WBGene00004048", "Q95XP4", "WBGene00003111", "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "O01325", "WBGene00009160" ] }, "reaction_10521210": { "compartment": "compartment_70101", "id": "reaction_10521210", "reactome": "R-CEL-399930", "name": "Activation of PAK by Rac1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10520686", "species_10521206" ], "products": [ "species_10521208", "species_10520688" ], "modifiers": [], "additional_components": [ "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "species_29438", "Q03206", "ced-10", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "U4PRY7", "WBGene00004047", "O45657", "WBGene00004048", "Q95XP4", "WBGene00003111", "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "O01325", "WBGene00009160", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "species_29438", "Q03206", "ced-10", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "U4PRY7", "WBGene00004047", "O45657", "WBGene00004048", "Q95XP4", "WBGene00003111", "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "O01325", "WBGene00009160", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911" ] }, "reaction_10521249": { "compartment": "compartment_876", "id": "reaction_10521249", "reactome": "R-CEL-399933", "name": "Sema3A binds Nrp-1 bound to PlexinA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10521243", "species_10521174" ], "products": [ "species_10521247", "species_10521239" ], "modifiers": [], "additional_components": [ "O45657", "WBGene00004048", "U4PRY7", "WBGene00004047", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "O17905", "WBGene00001490", "Q95XP4", "WBGene00003111", "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "Q95XP4", "WBGene00003111", "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "O45657", "WBGene00004048", "U4PRY7", "WBGene00004047", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "WBGene00001490" ] }, "reaction_10521260": { "compartment": "compartment_70101", "id": "reaction_10521260", "reactome": "R-CEL-399936", "name": "Inhibition of integrin activation by sequestering PIP5KIgamma", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10521256", "species_10521239" ], "products": [ "species_10521258", "species_10518194" ], "modifiers": [], "additional_components": [ "G5EGK1", "WBGene00006771", "O01759", "WBGene00004087", "WBGene00001490", "O01759", "WBGene00004087", "O17905", "WBGene00001490", "WBGene00006771" ] }, "reaction_10521608": { "compartment": "compartment_70101", "id": "reaction_10521608", "reactome": "R-CEL-416588", "name": "Activation of Rho by LARG and PDZ-RhoGEF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10521599", "species_29438" ], "products": [ "species_29420", "species_10509488" ], "modifiers": [ [ "species_10521605", "catalyst" ] ], "additional_components": [ "species_29420", "Q22038", "WBGene00004357", "Q22038", "WBGene00004357", "species_29438", "P24348", "WBGene00002299", "O45657", "WBGene00004048", "U4PRY7", "WBGene00004047", "Q17330", "WBGene00004889", "Q95XP4", "WBGene00003111", "Q9TYS4", "WBGene00004890", "G5EFE1", "WBGene00006468", "H2L0P5", "WBGene00022391" ] }, "reaction_10521610": { "compartment": "compartment_70101", "id": "reaction_10521610", "reactome": "R-CEL-416594", "name": "LARG and PDZ-RhoGEF binds to Plexin-B1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10521603", "species_10521601" ], "products": [ "species_10521605" ], "modifiers": [], "additional_components": [ "G5EFE1", "WBGene00006468", "H2L0P5", "WBGene00022391", "P24348", "WBGene00002299", "O45657", "WBGene00004048", "U4PRY7", "WBGene00004047", "Q17330", "WBGene00004889", "Q95XP4", "WBGene00003111", "Q9TYS4", "WBGene00004890", "P24348", "WBGene00002299", "O45657", "WBGene00004048", "U4PRY7", "WBGene00004047", "Q17330", "WBGene00004889", "Q95XP4", "WBGene00003111", "Q9TYS4", "WBGene00004890", "G5EFE1", "WBGene00006468", "H2L0P5", "WBGene00022391" ] }, "reaction_10518622": { "compartment": "compartment_70101", "id": "reaction_10518622", "reactome": "R-CEL-373750", "name": "SEMA4D interacts with Plexin-B1:ErbB2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10518607", "species_10518591", "species_113592" ], "products": [ "species_10518619", "species_29370" ], "modifiers": [ [ "species_10518607", "catalyst" ] ], "additional_components": [ "P24348", "WBGene00002299", "O45657", "WBGene00004048", "U4PRY7", "WBGene00004047", "Q17330", "WBGene00004889", "Q95XP4", "WBGene00003111", "Q9TYS4", "WBGene00004890", "P24348", "WBGene00002299", "O45657", "WBGene00004048", "U4PRY7", "WBGene00004047", "Q17330", "WBGene00004889", "Q95XP4", "WBGene00003111", "Q9TYS4", "WBGene00004890", "P24348", "WBGene00002299", "O45657", "WBGene00004048", "U4PRY7", "WBGene00004047" ] }, "reaction_10521585": { "compartment": "compartment_70101", "id": "reaction_10521585", "reactome": "R-CEL-416546", "name": "Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10521574" ], "products": [ "species_29372", "species_10521576" ], "modifiers": [ [ "species_10521582", "catalyst" ] ], "additional_components": [ "G5EBK8", "WBGene00004310", "species_29438", "species_29420", "G5EBK8", "WBGene00004310", "Q9XVQ7", "WBGene00008711", "O45657", "WBGene00004048", "U4PRY7", "WBGene00004047", "Q17330", "WBGene00004889", "Q95XP4", "WBGene00003111", "Q9TYS4", "WBGene00004890", "species_29438" ] }, "reaction_10521963": { "compartment": "compartment_70101", "id": "reaction_10521963", "reactome": "R-CEL-419646", "name": "SEMA4D interacts with Plexin-B1:Met", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10518591", "species_113592", "species_10521960" ], "products": [ "species_29370", "species_10521546" ], "modifiers": [ [ "species_10521960", "catalyst" ] ], "additional_components": [ "Q17330", "WBGene00004889", "Q95XP4", "WBGene00003111", "Q9TYS4", "WBGene00004890", "Q9XVQ7", "WBGene00008711", "O45657", "WBGene00004048", "U4PRY7", "WBGene00004047", "Q9XVQ7", "WBGene00008711", "O45657", "WBGene00004048", "U4PRY7", "WBGene00004047", "Q17330", "WBGene00004889", "Q95XP4", "WBGene00003111", "Q9TYS4", "WBGene00004890", "Q9XVQ7", "WBGene00008711", "O45657", "WBGene00004048", "U4PRY7", "WBGene00004047" ] }, "reaction_10521595": { "compartment": "compartment_70101", "id": "reaction_10521595", "reactome": "R-CEL-416559", "name": "Inactivation of Rho-GTP by p190RhoGAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10509488" ], "products": [ "species_10509486", "species_29372" ], "modifiers": [ [ "species_10521592", "catalyst" ] ], "additional_components": [ "Q22038", "WBGene00004357", "species_29438", "Q22038", "WBGene00004357", "species_29420", "O45611", "WBGene00010374", "Q9XVQ7", "WBGene00008711", "O45657", "WBGene00004048", "U4PRY7", "WBGene00004047", "Q17330", "WBGene00004889", "Q95XP4", "WBGene00003111", "Q9TYS4", "WBGene00004890", "species_29438" ] }, "reaction_10521597": { "compartment": "compartment_70101", "id": "reaction_10521597", "reactome": "R-CEL-416562", "name": "p190RhoGAP binds Plexin-B1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10521582", "species_10521590" ], "products": [ "species_10521592" ], "modifiers": [], "additional_components": [ "Q9XVQ7", "WBGene00008711", "O45657", "WBGene00004048", "U4PRY7", "WBGene00004047", "Q17330", "WBGene00004889", "Q95XP4", "WBGene00003111", "Q9TYS4", "WBGene00004890", "species_29438", "WBGene00010374", "O45611", "WBGene00010374", "Q9XVQ7", "WBGene00008711", "O45657", "WBGene00004048", "U4PRY7", "WBGene00004047", "Q17330", "WBGene00004889", "Q95XP4", "WBGene00003111", "Q9TYS4", "WBGene00004890", "species_29438" ] }, "reaction_10521550": { "compartment": "compartment_70101", "id": "reaction_10521550", "reactome": "R-CEL-400682", "name": "Active Rac1 interacts with Plexin-B1:Sema4D", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10521546", "species_10509457" ], "products": [ "species_10521548" ], "modifiers": [], "additional_components": [ "Q9XVQ7", "WBGene00008711", "O45657", "WBGene00004048", "U4PRY7", "WBGene00004047", "Q17330", "WBGene00004889", "Q95XP4", "WBGene00003111", "Q9TYS4", "WBGene00004890", "species_29438", "Q03206", "ced-10", "species_29438", "Q03206", "ced-10", "Q9XVQ7", "WBGene00008711", "O45657", "WBGene00004048", "U4PRY7", "WBGene00004047", "Q17330", "WBGene00004889", "Q95XP4", "WBGene00003111", "Q9TYS4", "WBGene00004890" ] }, "reaction_10518688": { "compartment": "compartment_876", "id": "reaction_10518688", "reactome": "R-CEL-374663", "name": "DCC interaction with Ezrin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10518684", "species_10518486" ], "products": [ "species_10518686" ], "modifiers": [], "additional_components": [ "species_179856", "G5EBK3", "WBGene00001333", "G5EF96", "phospho-unc-40", "species_179856", "G5EBK3", "WBGene00001333" ] }, "reaction_10518706": { "compartment": "compartment_70101", "id": "reaction_10518706", "reactome": "R-CEL-374667", "name": "DCC interaction with SIAH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10518702", "species_10518499" ], "products": [ "species_10518704" ], "modifiers": [], "additional_components": [ "WBGene00021369", "P34710", "unc-6", "G5EF96", "phospho-unc-40", "P34710", "unc-6", "G5EF96", "phospho-unc-40", "Q965X6", "WBGene00021369" ] }, "reaction_10518691": { "compartment": "compartment_70101", "id": "reaction_10518691", "reactome": "R-CEL-374664", "name": "Phosphorylation and activation of Ezrin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10518677" ], "products": [ "species_10518684", "species_29370" ], "modifiers": [ [ "species_10515209", "catalyst" ] ], "additional_components": [ "species_179856", "G5EBK3", "WBGene00001333", "species_179856", "G5EBK3", "WBGene00001333", "WBGene00006599" ] }, "reaction_10518533": { "compartment": "compartment_70101", "id": "reaction_10518533", "reactome": "R-CEL-373716", "name": "DCC interacting NCK-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10518510", "species_10518529" ], "products": [ "species_10518531" ], "modifiers": [], "additional_components": [ "WBGene00006410", "P34710", "unc-6", "G5EF96", "phospho-unc-40", "Q95YD4", "WBGene00002213", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "P34710", "unc-6", "G5EF96", "phospho-unc-40", "Q95YD4", "WBGene00002213", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q95PX0", "WBGene00006410" ] }, "reaction_10521893": { "compartment": "compartment_70101", "id": "reaction_10521893", "reactome": "R-CEL-418850", "name": "Activation of Cdc42", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10520579", "species_10521888" ], "products": [ "species_29420", "species_10521890" ], "modifiers": [ [ "species_10521888", "catalyst" ] ], "additional_components": [ "Q05062", "WBGene00000390", "species_29420", "P34710", "unc-6", "G5EF96", "phospho-unc-40", "Q95YD4", "WBGene00002213", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q95PX0", "WBGene00006410", "G5EEN3", "WBGene00000419", "P34710", "unc-6", "G5EF96", "phospho-unc-40", "Q95YD4", "WBGene00002213", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q95PX0", "WBGene00006410", "G5EEN3", "WBGene00000419", "Q05062", "WBGene00000390", "species_29438", "P34710", "unc-6", "G5EF96", "phospho-unc-40", "Q95YD4", "WBGene00002213", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q95PX0", "WBGene00006410", "G5EEN3", "WBGene00000419" ] }, "reaction_10518503": { "compartment": "compartment_876", "id": "reaction_10518503", "reactome": "R-CEL-373707", "name": "Netrin-1 induced DCC clustering", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10518486", "species_10518499" ], "products": [ "species_10518501" ], "modifiers": [], "additional_components": [ "P34710", "unc-6", "G5EF96", "phospho-unc-40", "P34710", "unc-6", "G5EF96", "phospho-unc-40" ] }, "reaction_10518505": { "compartment": "compartment_984", "id": "reaction_10518505", "reactome": "R-CEL-373711", "name": "DCC interaction with Netrin-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10518486", "species_10518497" ], "products": [ "species_10518499" ], "modifiers": [], "additional_components": [ "P34710", "unc-6", "G5EF96", "phospho-unc-40" ] }, "reaction_10521899": { "compartment": "compartment_70101", "id": "reaction_10521899", "reactome": "R-CEL-418858", "name": "RhoGTPase GEF's recruited to DCC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10521886", "species_10518531" ], "products": [ "species_10521888" ], "modifiers": [], "additional_components": [ "WBGene00000419", "P34710", "unc-6", "G5EF96", "phospho-unc-40", "Q95YD4", "WBGene00002213", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q95PX0", "WBGene00006410", "P34710", "unc-6", "G5EF96", "phospho-unc-40", "Q95YD4", "WBGene00002213", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q95PX0", "WBGene00006410", "G5EEN3", "WBGene00000419" ] }, "reaction_10521901": { "compartment": "compartment_70101", "id": "reaction_10521901", "reactome": "R-CEL-418868", "name": "Recruitment of Src and Fyn to DCC:FADK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10518527", "species_10518770" ], "products": [ "species_10518772" ], "modifiers": [], "additional_components": [ "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "P34710", "unc-6", "G5EF96", "phospho-unc-40", "Q95YD4", "WBGene00002213", "P34710", "unc-6", "G5EF96", "phospho-unc-40", "Q95YD4", "WBGene00002213", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635" ] }, "reaction_10518781": { "compartment": "compartment_70101", "id": "reaction_10518781", "reactome": "R-CEL-374701", "name": "Phosphorylation of DCC by Fyn", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10518772" ], "products": [ "species_29370", "species_10518529" ], "modifiers": [ [ "species_10518772", "catalyst" ] ], "additional_components": [ "P34710", "unc-6", "G5EF96", "phospho-unc-40", "Q95YD4", "WBGene00002213", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "P34710", "unc-6", "G5EF96", "phospho-unc-40", "Q95YD4", "WBGene00002213", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "P34710", "unc-6", "G5EF96", "phospho-unc-40", "Q95YD4", "WBGene00002213", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635" ] }, "reaction_10519264": { "compartment": "compartment_876", "id": "reaction_10519264", "reactome": "R-CEL-376122", "name": "DSCAM/DSCAML1 homodimerization", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10519260" ], "products": [ "species_10519262" ], "modifiers": [], "additional_components": [ "Q18806", "WBGene00004370", "H2KZ60", "WBGene00016354", "Q18806", "WBGene00004370", "H2KZ60", "WBGene00016354" ] }, "reaction_10526129": { "compartment": "compartment_70101", "id": "reaction_10526129", "reactome": "R-CEL-451347", "name": "Activation of JNK by DSCAM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10510931" ], "products": [ "species_29370", "species_10510951" ], "modifiers": [ [ "species_10519282", "catalyst" ] ], "additional_components": [ "WBGene00002178", "WBGene00002178", "species_29438", "Q03206", "ced-10", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "Q18806", "WBGene00004370", "H2KZ60", "WBGene00016354" ] }, "reaction_10519284": { "compartment": "compartment_70101", "id": "reaction_10519284", "reactome": "R-CEL-376123", "name": "DSCAM associates with Rac1-GTP:pPAK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10519252", "species_10519280" ], "products": [ "species_10519282" ], "modifiers": [], "additional_components": [ "Q18806", "WBGene00004370", "H2KZ60", "WBGene00016354", "species_29438", "Q03206", "ced-10", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "species_29438", "Q03206", "ced-10", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "Q18806", "WBGene00004370", "H2KZ60", "WBGene00016354" ] }, "reaction_10526154": { "compartment": "compartment_70101", "id": "reaction_10526154", "reactome": "R-CEL-451366", "name": "Activation of p38MAPK by DSCAM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10526151" ], "products": [ "species_29370", "species_10512658" ], "modifiers": [ [ "species_10519282", "catalyst" ] ], "additional_components": [ "Q17446", "WBGene00004055", "Q8MXI4", "WBGene00004056", "species_114632", "Q17446", "WBGene00004055", "Q8MXI4", "WBGene00004056", "species_114632", "species_29438", "Q03206", "ced-10", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "Q18806", "WBGene00004370", "H2KZ60", "WBGene00016354" ] }, "reaction_10518679": { "compartment": "compartment_70101", "id": "reaction_10518679", "reactome": "R-CEL-374662", "name": "Translocation of Ezrin to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10518675", "species_179856" ], "products": [ "species_10518677" ], "modifiers": [], "additional_components": [ "WBGene00001333", "species_179856", "G5EBK3", "WBGene00001333" ] }, "reaction_10527529": { "compartment": "compartment_876", "id": "reaction_10527529", "reactome": "R-CEL-593685", "name": "Netrin-4 binds DCC/UNC5A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10527518", "species_10527525" ], "products": [ "species_10527527" ], "modifiers": [], "additional_components": [ "WBGene00002247", "Q26261", "WBGene00006745", "G5EF96", "phospho-unc-40", "Q26261", "WBGene00006745", "G5EF96", "phospho-unc-40", "O44565", "WBGene00002247" ] }, "reaction_10518700": { "compartment": "compartment_70101", "id": "reaction_10518700", "reactome": "R-CEL-374665", "name": "DCC interaction with SIAH1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10518696", "species_10518499" ], "products": [ "species_10518698" ], "modifiers": [], "additional_components": [ "WBGene00021369", "P34710", "unc-6", "G5EF96", "phospho-unc-40", "P34710", "unc-6", "G5EF96", "phospho-unc-40", "Q965X6", "WBGene00021369" ] }, "reaction_10518727": { "compartment": "compartment_70101", "id": "reaction_10518727", "reactome": "R-CEL-374673", "name": "L1 binds RanBPM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10518718", "species_10518723" ], "products": [ "species_10518725" ], "modifiers": [], "additional_components": [ "Q21465", "WBGene00019727", "Q5WRR1", "WBGene00006942", "WBGene00013202", "Q9XWK4", "WBGene00013202", "Q21465", "WBGene00019727", "Q5WRR1", "WBGene00006942" ] }, "reaction_10518546": { "compartment": "compartment_876", "id": "reaction_10518546", "reactome": "R-CEL-373730", "name": "Neurofascin and NrCAM heterodimerization", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10518542", "species_10518540" ], "products": [ "species_10518544" ], "modifiers": [], "additional_components": [ "WBGene00004732", "WBGene00004732", "Q53U87", "WBGene00004732" ] }, "reaction_10515214": { "compartment": "compartment_876", "id": "reaction_10515214", "reactome": "R-CEL-202222", "name": "Phosphorylation of PKC theta", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10515204" ], "products": [ "species_10515211", "species_29370" ], "modifiers": [ [ "species_10515195", "catalyst" ] ], "additional_components": [ "P34722", "WBGene00006599", "species_112275", "species_112275", "P34722", "WBGene00006599", "Q9UA62", "WBGene00021022", "species_202247", "species_179838" ] }, "reaction_10508214": { "compartment": "compartment_5460", "id": "reaction_10508214", "reactome": "R-CEL-77271", "name": "3-Oxotetradecanoyl-CoA+CoA-SH<=>Lauroyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_77269" ], "products": [ "species_77261", "species_113559" ], "modifiers": [ [ "species_10508211", "catalyst" ] ], "additional_components": [ "P34255", "WBGene00015125", "Q9GYT0", "WBGene00020347" ] }, "reaction_10508217": { "compartment": "compartment_5460", "id": "reaction_10508217", "reactome": "R-CEL-77277", "name": "trans-Tetradec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxytetradecanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77273", "species_113521" ], "products": [ "species_77276" ], "modifiers": [ [ "species_10508211", "catalyst" ] ], "additional_components": [ "P34255", "WBGene00015125", "Q9GYT0", "WBGene00020347" ] }, "reaction_10508220": { "compartment": "compartment_5460", "id": "reaction_10508220", "reactome": "R-CEL-77283", "name": "(S)-3-Hydroxytetradecanoyl-CoA+NAD<=>3-Oxotetradecanoyl-CoA+NADH+H", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77276", "species_113526" ], "products": [ "species_113529", "species_77269", "species_29362" ], "modifiers": [ [ "species_10508211", "catalyst" ] ], "additional_components": [ "P34255", "WBGene00015125", "Q9GYT0", "WBGene00020347" ] }, "reaction_10510256": { "compartment": "compartment_70101", "id": "reaction_10510256", "reactome": "R-CEL-163764", "name": "D-fructose 6-phosphate + D-erythrose 4-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29512", "species_29878" ], "products": [ "species_29578", "species_29882" ], "modifiers": [ [ "species_10503949", "catalyst" ] ], "additional_components": [ "Q966C7", "WBGene00021286" ] }, "reaction_10510242": { "compartment": "compartment_70101", "id": "reaction_10510242", "reactome": "R-CEL-163741", "name": "D-glyceraldehyde 3-phosphate + sedoheptulose 7-phosphate<=> xylulose 5-phosphate+ribose 5-phosphate ", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29882", "species_29578" ], "products": [ "species_29790", "species_73578" ], "modifiers": [ [ "species_10503939", "catalyst" ] ], "additional_components": [ "O17759", "WBGene00008506", "species_114632", "species_8878387" ] }, "reaction_10510252": { "compartment": "compartment_70101", "id": "reaction_10510252", "reactome": "R-CEL-163751", "name": "D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate <=> xylulose 5-phosphate + D-erythrose 4-phosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29578", "species_29512" ], "products": [ "species_29790", "species_29878" ], "modifiers": [ [ "species_10503939", "catalyst" ] ], "additional_components": [ "O17759", "WBGene00008506", "species_114632", "species_8878387" ] }, "reaction_10513329": { "compartment": "compartment_984", "id": "reaction_10513329", "reactome": "R-CEL-192417", "name": "Digestion of cholesterol esters by extracellular CEL (bile salt-dependent lipase)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_171076" ], "products": [ "species_171149", "species_174602" ], "modifiers": [ [ "species_10513326", "catalyst" ] ], "additional_components": [ "CHEBI:17687", "CHEBI:28865", "CHEBI:16755", "CHEBI:36274", "species_193451", "CHEBI:9407", "Q20826", "WBGene00018878", "Q9XTG1", "WBGene00006412" ] }, "reaction_10513332": { "compartment": "compartment_984", "id": "reaction_10513332", "reactome": "R-CEL-192425", "name": "Digestion of monoacylglycerols by extracellular CEL (bile salt-dependent lipase)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_6814795" ], "products": [ "species_174602", "species_192438" ], "modifiers": [ [ "species_10513326", "catalyst" ] ], "additional_components": [ "CHEBI:17687", "CHEBI:28865", "CHEBI:16755", "CHEBI:36274", "species_193451", "CHEBI:9407", "Q20826", "WBGene00018878", "Q9XTG1", "WBGene00006412" ] }, "reaction_10513334": { "compartment": "compartment_984", "id": "reaction_10513334", "reactome": "R-CEL-192430", "name": "Digestion of triacylglycerols by extracellular CEL (bile salt-dependent lipase)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_171126" ], "products": [ "species_174602", "species_174675" ], "modifiers": [ [ "species_10513326", "catalyst" ] ], "additional_components": [ "CHEBI:17687", "CHEBI:28865", "CHEBI:16755", "CHEBI:36274", "species_193451", "CHEBI:9407", "Q20826", "WBGene00018878", "Q9XTG1", "WBGene00006412" ] }, "reaction_10570265": { "compartment": "compartment_984", "id": "reaction_10570265", "reactome": "R-CEL-8979996", "name": "LIPs hydrolyze TG to DAG and LCFA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_171126" ], "products": [ "species_174602", "species_174675" ], "modifiers": [ [ "species_10570262", "catalyst" ] ], "additional_components": [] }, "reaction_10554517": { "compartment": "compartment_70101", "id": "reaction_10554517", "reactome": "R-CEL-5661256", "name": "AKR1A1 reduces D-glucuronate to L-gulonate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_5661264", "species_29364" ], "products": [ "species_29366", "species_5661268" ], "modifiers": [ [ "species_10554514", "catalyst" ] ], "additional_components": [ "WBGene00012722" ] }, "reaction_10554535": { "compartment": "compartment_70101", "id": "reaction_10554535", "reactome": "R-CEL-5662466", "name": "XYLB phosphorylates D-xylulose", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_5661281" ], "products": [ "species_29790", "species_29370" ], "modifiers": [ [ "species_10554532", "catalyst" ] ], "additional_components": [ "WBGene00011147" ] }, "reaction_10554538": { "compartment": "compartment_70101", "id": "reaction_10554538", "reactome": "R-CEL-5662471", "name": "SORD tetramer oxidizes xylitol to D-xylulose", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5660033", "species_29360" ], "products": [ "species_70106", "species_5661281", "species_73473" ], "modifiers": [ [ "species_10554251", "catalyst" ] ], "additional_components": [ "species_216785", "Q21702", "WBGene00011003" ] }, "reaction_10554509": { "compartment": "compartment_70101", "id": "reaction_10554509", "reactome": "R-CEL-5661240", "name": "DCXR tetramer reduces L-xylulose to xylitol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_5660036" ], "products": [ "species_5660033", "species_29366" ], "modifiers": [ [ "species_10554506", "catalyst" ] ], "additional_components": [ "Q21929", "WBGene00000984" ] }, "reaction_10554527": { "compartment": "compartment_70101", "id": "reaction_10554527", "reactome": "R-CEL-5661290", "name": "CRYL1 dimer dehydrogenates L-gulonate to 3-dehydro-L-gulonate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5661268", "species_29360" ], "products": [ "species_70106", "species_5661262", "species_73473" ], "modifiers": [ [ "species_10554524", "catalyst" ] ], "additional_components": [ "C0VXV5", "WBGene00022130" ] }, "reaction_10543520": { "compartment": "compartment_984", "id": "reaction_10543520", "reactome": "R-CEL-2213201", "name": "Formation of collagen fibres", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10534604" ], "products": [ "species_10543518" ], "modifiers": [], "additional_components": [ "Q9N4U2", "WBGene00000647", "O76368", "WBGene00000674", "Q09457", "WBGene00000251", "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689", "P17140", "WBGene00002280", "Q21437", "WBGene00000659", "Q9N4U2", "WBGene00000647", "O76368", "WBGene00000674", "Q09457", "WBGene00000251", "P17140", "WBGene00002280", "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689", "Q21437", "WBGene00000659" ] }, "reaction_10543796": { "compartment": "compartment_984", "id": "reaction_10543796", "reactome": "R-CEL-2299620", "name": "Collagen XI cross-links with collagen II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10517286", "species_10534598" ], "products": [ "species_10543794" ], "modifiers": [], "additional_components": [ "O76368", "WBGene00000674", "Q09457", "WBGene00000251", "Q9N4U2", "WBGene00000647", "O76368", "WBGene00000674", "Q09457", "WBGene00000251", "Q9N4U2", "WBGene00000647", "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689", "O76368", "WBGene00000674", "Q09457", "WBGene00000251", "Q9N4U2", "WBGene00000647", "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689" ] }, "reaction_10543528": { "compartment": "compartment_984", "id": "reaction_10543528", "reactome": "R-CEL-2213207", "name": "Formation of collagen networks", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10543522" ], "products": [ "species_10543526" ], "modifiers": [], "additional_components": [ "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689", "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689" ] }, "reaction_10544002": { "compartment": "compartment_984", "id": "reaction_10544002", "reactome": "R-CEL-2395223", "name": "Formation of hydroxylysyl-pyridinoline cross-links", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10543979" ], "products": [ "species_10544000" ], "modifiers": [], "additional_components": [ "Q9N4U2", "WBGene00000647", "Q9N4U2", "WBGene00000647" ] }, "reaction_10544004": { "compartment": "compartment_984", "id": "reaction_10544004", "reactome": "R-CEL-2395257", "name": "Formation of dehydro-hydroxylysino-norleucine cross-links", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10540843", "species_10509625" ], "products": [ "species_10543638" ], "modifiers": [], "additional_components": [ "Q9N4U2", "WBGene00000647", "Q9N4U2", "WBGene00000647", "Q9N4U2", "WBGene00000647" ] }, "reaction_10543701": { "compartment": "compartment_984", "id": "reaction_10543701", "reactome": "R-CEL-2243931", "name": "Formation of dehydro-lysinonorleucine cross-links", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10540843", "species_10509625" ], "products": [ "species_10543699" ], "modifiers": [], "additional_components": [ "Q9N4U2", "WBGene00000647", "Q9N4U2", "WBGene00000647", "Q9N4U2", "WBGene00000647" ] }, "reaction_10544086": { "compartment": "compartment_984", "id": "reaction_10544086", "reactome": "R-CEL-2395324", "name": "Formation of hydroxylysyl-pyrrole cross-links", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10543979", "species_10543638" ], "products": [ "species_10544084" ], "modifiers": [], "additional_components": [ "Q9N4U2", "WBGene00000647", "Q9N4U2", "WBGene00000647", "Q9N4U2", "WBGene00000647" ] }, "reaction_10544024": { "compartment": "compartment_984", "id": "reaction_10544024", "reactome": "R-CEL-2395302", "name": "Formation of hydroxylysino-5-ketonorleucine cross-links", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509625", "species_10544022" ], "products": [ "species_10543979" ], "modifiers": [], "additional_components": [ "Q9N4U2", "WBGene00000647", "Q9N4U2", "WBGene00000647", "Q9N4U2", "WBGene00000647" ] }, "reaction_10544026": { "compartment": "compartment_984", "id": "reaction_10544026", "reactome": "R-CEL-2395314", "name": "Formation of lysino-5-ketonorleucine cross-links", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509625", "species_10544022" ], "products": [ "species_10543730" ], "modifiers": [], "additional_components": [ "Q9N4U2", "WBGene00000647", "Q9N4U2", "WBGene00000647", "Q9N4U2", "WBGene00000647" ] }, "reaction_10543754": { "compartment": "compartment_984", "id": "reaction_10543754", "reactome": "R-CEL-2250301", "name": "Formation of lysyl-pyrrole cross-links", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10543638", "species_10543730" ], "products": [ "species_10543752" ], "modifiers": [], "additional_components": [ "Q9N4U2", "WBGene00000647", "Q9N4U2", "WBGene00000647", "Q9N4U2", "WBGene00000647" ] }, "reaction_10543642": { "compartment": "compartment_984", "id": "reaction_10543642", "reactome": "R-CEL-2243926", "name": "Formation of histidino-hydroxylysinonorleucine cross-links", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509625", "species_10543638" ], "products": [ "species_10543640" ], "modifiers": [], "additional_components": [ "Q9N4U2", "WBGene00000647", "Q9N4U2", "WBGene00000647", "Q9N4U2", "WBGene00000647" ] }, "reaction_10544063": { "compartment": "compartment_984", "id": "reaction_10544063", "reactome": "R-CEL-2395322", "name": "Formation of lysyl-pyridinoline cross-links", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10543979", "species_10543730" ], "products": [ "species_10544061" ], "modifiers": [], "additional_components": [ "Q9N4U2", "WBGene00000647", "Q9N4U2", "WBGene00000647", "Q9N4U2", "WBGene00000647" ] }, "reaction_10543532": { "compartment": "compartment_984", "id": "reaction_10543532", "reactome": "R-CEL-2213208", "name": "Type X collagen associates with collagen type II fibrils", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10517286", "species_10543524" ], "products": [ "species_10543530" ], "modifiers": [], "additional_components": [ "O76368", "WBGene00000674", "Q09457", "WBGene00000251", "Q9N4U2", "WBGene00000647", "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689", "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689", "O76368", "WBGene00000674", "Q09457", "WBGene00000251", "Q9N4U2", "WBGene00000647" ] }, "reaction_10534606": { "compartment": "compartment_984", "id": "reaction_10534606", "reactome": "R-CEL-1474266", "name": "Formation of collagen fibrils", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10534596" ], "products": [ "species_10534604" ], "modifiers": [], "additional_components": [ "P17140", "WBGene00002280", "O76368", "WBGene00000674", "Q09457", "WBGene00000251", "Q9N4U2", "WBGene00000647", "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689", "Q21437", "WBGene00000659", "Q9N4U2", "WBGene00000647", "O76368", "WBGene00000674", "Q09457", "WBGene00000251", "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689", "P17140", "WBGene00002280", "Q21437", "WBGene00000659" ] }, "reaction_10556034": { "compartment": "compartment_5460", "id": "reaction_10556034", "reactome": "R-CEL-5688276", "name": "SIRT4 transfers ADPRib to GLUD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10503183", "species_113526" ], "products": [ "species_10556024", "species_5688274" ], "modifiers": [ [ "species_10556031", "catalyst" ] ], "additional_components": [ "WBGene00014095", "WBGene00014095", "Q20480", "WBGene00004801", "species_216785" ] }, "reaction_10573249": { "compartment": "compartment_70101", "id": "reaction_10573249", "reactome": "R-CEL-9698844", "name": "MLKL binds HSP90:CDC37", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10550681", "species_10538179", "species_10538177" ], "products": [ "species_10573247" ], "modifiers": [], "additional_components": [ "WBGene00003030", "Q18688", "WBGene00000915", "O02108", "WBGene00021097", "O02108", "WBGene00021097", "Q18688", "WBGene00000915", "Q07292", "WBGene00003030" ] }, "reaction_10505687": { "compartment": "compartment_70101", "id": "reaction_10505687", "reactome": "R-CEL-72621", "name": "Ribosomal scanning ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10505676", "species_113592" ], "products": [ "species_29372", "species_10505676", "species_29370" ], "modifiers": [ [ "species_72617", "catalyst" ], [ "species_113592", "catalyst" ] ], "additional_components": [ "A0A486WX07", "WBGene00002066", "Q20935", "WBGene00018997", "P27639", "WBGene00002083", "O61955", "WBGene00002061", "species_29438", "Q9BKU3", "WBGene00021351", "Q21230", "WBGene00010560", "Q95XR0", "WBGene00021466", "P51403", "WBGene00004471", "Q9NEN6", "WBGene00004475", "Q8WQA8", "WBGene00004489", "Q23312", "WBGene00004476", "O01869", "WBGene00004479", "P49197", "WBGene00004490", "P48156", "WBGene00004477", "Q20206", "WBGene00004480", "Q19877", "WBGene00004492", "Q20228", "WBGene00004478", "P49196", "WBGene00004481", "Q1XFY9", "WBGene00004493", "P46769", "WBGene00004469", "P51404", "WBGene00004482", "P52821", "WBGene00004494", "Q9TXP0", "WBGene00004496", "P48150", "WBGene00004483", "O45499", "WBGene00004495", "Q9N3X2", "WBGene00004473", "Q9XVP0", "WBGene00004484", "Q95Y04", "WBGene00004497", "Q22054", "WBGene00004485", "P90983", "WBGene00004498", "O01692", "WBGene00004486", "P48152", "WBGene00004472", "O18240", "WBGene00004487", "O18650", "WBGene00004488", "P48154", "WBGene00004470", "O17218", "WBGene00004491", "P49041", "WBGene00004474", "Q95QW0", "WBGene00015920", "O01974", "WBGene00001231", "Q94261", "WBGene00019543", "P34339", "WBGene00001209", "Q9XWP7", "WBGene00012738", "P30642", "WBGene00001227", "Q965S8", "WBGene00001232", "O02328", "WBGene00001226", "Q19706", "WBGene00001230", "O61820", "WBGene00001228", "Q18967", "WBGene00001229", "Q9XUP3", "WBGene00001233", "Q9XWI6", "WBGene00001225", "Q9TXU7", "WBGene00019162", "H2L0A8", "WBGene00019157", "A0A486WX07", "WBGene00002066", "Q20935", "WBGene00018997", "P27639", "WBGene00002083", "O61955", "WBGene00002061", "species_29438", "Q9BKU3", "WBGene00021351", "Q21230", "WBGene00010560", "Q95XR0", "WBGene00021466", "P51403", "WBGene00004471", "Q9NEN6", "WBGene00004475", "Q8WQA8", "WBGene00004489", "Q23312", "WBGene00004476", "O01869", "WBGene00004479", "P49197", "WBGene00004490", "P48156", "WBGene00004477", "Q20206", "WBGene00004480", "Q19877", "WBGene00004492", "Q20228", "WBGene00004478", "P49196", "WBGene00004481", "Q1XFY9", "WBGene00004493", "P46769", "WBGene00004469", "P51404", "WBGene00004482", "P52821", "WBGene00004494", "Q9TXP0", "WBGene00004496", "P48150", "WBGene00004483", "O45499", "WBGene00004495", "Q9N3X2", "WBGene00004473", "Q9XVP0", "WBGene00004484", "Q95Y04", "WBGene00004497", "Q22054", "WBGene00004485", "P90983", "WBGene00004498", "O01692", "WBGene00004486", "P48152", "WBGene00004472", "O18240", "WBGene00004487", "O18650", "WBGene00004488", "P48154", "WBGene00004470", "O17218", "WBGene00004491", "P49041", "WBGene00004474", "Q95QW0", "WBGene00015920", "O01974", "WBGene00001231", "Q94261", "WBGene00019543", "P34339", "WBGene00001209", "Q9XWP7", "WBGene00012738", "P30642", "WBGene00001227", "Q965S8", "WBGene00001232", "O02328", "WBGene00001226", "Q19706", "WBGene00001230", "O61820", "WBGene00001228", "Q18967", "WBGene00001229", "Q9XUP3", "WBGene00001233", "Q9XWI6", "WBGene00001225", "Q9TXU7", "WBGene00019162", "H2L0A8", "WBGene00019157" ] }, "reaction_10505999": { "compartment": "compartment_70101", "id": "reaction_10505999", "reactome": "R-CEL-72697", "name": "Start codon recognition", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10505631", "species_10505614", "species_10505676", "species_72617", "species_10505681" ], "products": [ "species_10505631", "species_10505614", "species_10505676", "species_72617", "species_10505681" ], "modifiers": [ [ "species_72617", "catalyst" ] ], "additional_components": [ "Q9BKU3", "WBGene00021351", "Q21230", "WBGene00010560", "Q95XR0", "WBGene00021466", "WBGene00019162", "A0A486WX07", "WBGene00002066", "Q20935", "WBGene00018997", "P27639", "WBGene00002083", "O61955", "WBGene00002061", "species_29438", "Q9BKU3", "WBGene00021351", "Q21230", "WBGene00010560", "Q95XR0", "WBGene00021466", "P51403", "WBGene00004471", "Q9NEN6", "WBGene00004475", "Q8WQA8", "WBGene00004489", "Q23312", "WBGene00004476", "O01869", "WBGene00004479", "P49197", "WBGene00004490", "P48156", "WBGene00004477", "Q20206", "WBGene00004480", "Q19877", "WBGene00004492", "Q20228", "WBGene00004478", "P49196", "WBGene00004481", "Q1XFY9", "WBGene00004493", "P46769", "WBGene00004469", "P51404", "WBGene00004482", "P52821", "WBGene00004494", "Q9TXP0", "WBGene00004496", "P48150", "WBGene00004483", "O45499", "WBGene00004495", "Q9N3X2", "WBGene00004473", "Q9XVP0", "WBGene00004484", "Q95Y04", "WBGene00004497", "Q22054", "WBGene00004485", "P90983", "WBGene00004498", "O01692", "WBGene00004486", "P48152", "WBGene00004472", "O18240", "WBGene00004487", "O18650", "WBGene00004488", "P48154", "WBGene00004470", "O17218", "WBGene00004491", "P49041", "WBGene00004474", "Q95QW0", "WBGene00015920", "O01974", "WBGene00001231", "Q94261", "WBGene00019543", "P34339", "WBGene00001209", "Q9XWP7", "WBGene00012738", "P30642", "WBGene00001227", "Q965S8", "WBGene00001232", "O02328", "WBGene00001226", "Q19706", "WBGene00001230", "O61820", "WBGene00001228", "Q18967", "WBGene00001229", "Q9XUP3", "WBGene00001233", "Q9XWI6", "WBGene00001225", "Q9TXU7", "WBGene00019162", "H2L0A8", "WBGene00019157", "WBGene00016496", "Q9BKU3", "WBGene00021351", "Q21230", "WBGene00010560", "Q95XR0", "WBGene00021466", "WBGene00019162", "A0A486WX07", "WBGene00002066", "Q20935", "WBGene00018997", "P27639", "WBGene00002083", "O61955", "WBGene00002061", "species_29438", "Q9BKU3", "WBGene00021351", "Q21230", "WBGene00010560", "Q95XR0", "WBGene00021466", "P51403", "WBGene00004471", "Q9NEN6", "WBGene00004475", "Q8WQA8", "WBGene00004489", "Q23312", "WBGene00004476", "O01869", "WBGene00004479", "P49197", "WBGene00004490", "P48156", "WBGene00004477", "Q20206", "WBGene00004480", "Q19877", "WBGene00004492", "Q20228", "WBGene00004478", "P49196", "WBGene00004481", "Q1XFY9", "WBGene00004493", "P46769", "WBGene00004469", "P51404", "WBGene00004482", "P52821", "WBGene00004494", "Q9TXP0", "WBGene00004496", "P48150", "WBGene00004483", "O45499", "WBGene00004495", "Q9N3X2", "WBGene00004473", "Q9XVP0", "WBGene00004484", "Q95Y04", "WBGene00004497", "Q22054", "WBGene00004485", "P90983", "WBGene00004498", "O01692", "WBGene00004486", "P48152", "WBGene00004472", "O18240", "WBGene00004487", "O18650", "WBGene00004488", "P48154", "WBGene00004470", "O17218", "WBGene00004491", "P49041", "WBGene00004474", "Q95QW0", "WBGene00015920", "O01974", "WBGene00001231", "Q94261", "WBGene00019543", "P34339", "WBGene00001209", "Q9XWP7", "WBGene00012738", "P30642", "WBGene00001227", "Q965S8", "WBGene00001232", "O02328", "WBGene00001226", "Q19706", "WBGene00001230", "O61820", "WBGene00001228", "Q18967", "WBGene00001229", "Q9XUP3", "WBGene00001233", "Q9XWI6", "WBGene00001225", "Q9TXU7", "WBGene00019162", "H2L0A8", "WBGene00019157", "WBGene00016496" ] }, "reaction_10567089": { "compartment": "compartment_70101", "id": "reaction_10567089", "reactome": "R-CEL-8870469", "name": "RGGT geranylgeranylates RAB proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1131164", "species_10566884" ], "products": [ "species_10567086", "species_10567084", "species_1132084" ], "modifiers": [ [ "species_10566884", "catalyst" ] ], "additional_components": [ "A0A2C9C2Y0", "WBGene00006833", "G5EBF0", "WBGene00011083", "Q94986", "WBGene00004267", "O01803", "WBGene00004274", "P91857", "WBGene00004268", "G5EFC1", "WBGene00004272", "Q21137", "WBGene00019317", "Q9UAQ6", "WBGene00004266", "species_29420", "Q9TYY0", "WBGene00019778", "P41992", "WBGene00015099", "Q9BKQ5", "WBGene00022051", "species_1131164", "Q9TYY0", "WBGene00019778", "P41992", "WBGene00015099", "species_1131164", "Q9BKQ5", "WBGene00022051", "G5EFC1", "WBGene00004272", "Q21137", "WBGene00019317", "A0A2C9C2Y0", "WBGene00006833", "O01803", "WBGene00004274", "Q94986", "WBGene00004267", "P91857", "WBGene00004268", "Q9UAQ6", "WBGene00004266", "G5EBF0", "WBGene00011083", "species_29420", "A0A2C9C2Y0", "WBGene00006833", "G5EBF0", "WBGene00011083", "Q94986", "WBGene00004267", "O01803", "WBGene00004274", "P91857", "WBGene00004268", "G5EFC1", "WBGene00004272", "Q21137", "WBGene00019317", "Q9UAQ6", "WBGene00004266", "species_29420", "Q9TYY0", "WBGene00019778", "P41992", "WBGene00015099", "Q9BKQ5", "WBGene00022051", "species_1131164" ] }, "reaction_10566886": { "compartment": "compartment_70101", "id": "reaction_10566886", "reactome": "R-CEL-8870466", "name": "RGGT:CHM binds RABs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10566765", "species_10566882" ], "products": [ "species_10566884" ], "modifiers": [], "additional_components": [ "Q9TYY0", "WBGene00019778", "P41992", "WBGene00015099", "Q9BKQ5", "WBGene00022051", "species_1131164", "A0A2C9C2Y0", "WBGene00006833", "G5EBF0", "WBGene00011083", "Q94986", "WBGene00004267", "O01803", "WBGene00004274", "P91857", "WBGene00004268", "G5EFC1", "WBGene00004272", "Q21137", "WBGene00019317", "Q9UAQ6", "WBGene00004266", "species_29420", "A0A2C9C2Y0", "WBGene00006833", "G5EBF0", "WBGene00011083", "Q94986", "WBGene00004267", "O01803", "WBGene00004274", "P91857", "WBGene00004268", "G5EFC1", "WBGene00004272", "Q21137", "WBGene00019317", "Q9UAQ6", "WBGene00004266", "species_29420", "Q9TYY0", "WBGene00019778", "P41992", "WBGene00015099", "Q9BKQ5", "WBGene00022051", "species_1131164" ] }, "reaction_10566761": { "compartment": "compartment_70101", "id": "reaction_10566761", "reactome": "R-CEL-8870461", "name": "RABGGTA and RABGGTB bind", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10566757", "species_10566755" ], "products": [ "species_10566759" ], "modifiers": [], "additional_components": [ "WBGene00015099", "WBGene00019778", "Q9TYY0", "WBGene00019778", "P41992", "WBGene00015099" ] }, "reaction_10566767": { "compartment": "compartment_70101", "id": "reaction_10566767", "reactome": "R-CEL-8870465", "name": "RGGT binds the RAB-binding subunit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1131164", "species_10562902", "species_10566759" ], "products": [ "species_10566765" ], "modifiers": [], "additional_components": [ "WBGene00022051", "Q9TYY0", "WBGene00019778", "P41992", "WBGene00015099", "Q9TYY0", "WBGene00019778", "P41992", "WBGene00015099", "Q9BKQ5", "WBGene00022051", "species_1131164" ] }, "reaction_10565410": { "compartment": "compartment_70101", "id": "reaction_10565410", "reactome": "R-CEL-8853379", "name": "ENGASE hydrolyses unfolded protein:(GlcNAc)2 (Man(9-5)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10531865" ], "products": [ "species_8853371", "species_8853381" ], "modifiers": [ [ "species_10565407", "catalyst" ] ], "additional_components": [ "CHEBI:60627", "CHEBI:60628", "species_915149", "CHEBI:60629", "species_964740", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "species_8853396", "CHEBI:91284", "CHEBI:91283", "CHEBI:91282", "CHEBI:91281", "WBGene00017164" ] }, "reaction_10565052": { "compartment": "compartment_70101", "id": "reaction_10565052", "reactome": "R-CEL-8850594", "name": "Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10531865" ], "products": [ "species_1022114", "species_8852852" ], "modifiers": [ [ "species_10565049", "catalyst" ] ], "additional_components": [ "CHEBI:60627", "CHEBI:60628", "species_915149", "CHEBI:60629", "species_964740", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "CHEBI:60628", "CHEBI:60629", "species_964740", "species_915149", "CHEBI:60627", "Q9TW67", "WBGene00010160", "Q9TXH9", "WBGene00017733", "Q23451", "WBGene00013924", "P90859", "WBGene00009164", "Q93561", "WBGene00000843", "P54812", "WBGene00008053", "O16368", "WBGene00004502" ] }, "reaction_10531867": { "compartment": "compartment_70101", "id": "reaction_10531867", "reactome": "R-CEL-1022127", "name": "Ub-unfolded protein:(GlcNAc)2 (Man)9-5 translocates from ERQC to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10531863" ], "products": [ "species_10531865" ], "modifiers": [], "additional_components": [ "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "CHEBI:60627", "CHEBI:60628", "species_915149", "CHEBI:60629", "species_964740", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727" ] }, "reaction_10528423": { "compartment": "compartment_17957", "id": "reaction_10528423", "reactome": "R-CEL-901047", "name": "Binding of ERp57", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10527333", "species_10528419" ], "products": [ "species_10528421" ], "modifiers": [], "additional_components": [ "WBGene00003964", "CHEBI:59080", "P34652", "WBGene00000567", "P27798", "WBGene00000802", "CHEBI:59080", "P34652", "WBGene00000567", "P27798", "WBGene00000802", "G5ED07", "WBGene00003964" ] }, "reaction_10529604": { "compartment": "compartment_20699", "id": "reaction_10529604", "reactome": "R-CEL-964768", "name": "Addition of GlcNAc to the glycan on the A arm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_914003", "species_964740" ], "products": [ "species_964837", "species_205687" ], "modifiers": [ [ "species_10529601", "catalyst" ] ], "additional_components": [ "WBGene00001638" ] }, "reaction_10530596": { "compartment": "compartment_20699", "id": "reaction_10530596", "reactome": "R-CEL-975916", "name": "Addition of GlcNAc to position 5 by MGAT5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_914003", "species_975910" ], "products": [ "species_981617" ], "modifiers": [ [ "species_10530593", "catalyst" ] ], "additional_components": [ "WBGene00001627" ] }, "reaction_10525152": { "compartment": "compartment_12045", "id": "reaction_10525152", "reactome": "R-CEL-446207", "name": "ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_162756", "species_449222" ], "products": [ "species_449293", "species_110096" ], "modifiers": [ [ "species_10525149", "catalyst" ] ], "additional_components": [ "P92012", "WBGene00011193", "U4PE03", "WBGene00019725" ] }, "reaction_10525186": { "compartment": "compartment_12045", "id": "reaction_10525186", "reactome": "R-CEL-446218", "name": "Addition of the first mannose to the N-glycan precursor by ALG1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_162860", "species_449293" ], "products": [ "species_29420", "species_449283" ], "modifiers": [ [ "species_10525183", "catalyst" ] ], "additional_components": [ "WBGene00020820" ] }, "reaction_10525074": { "compartment": "compartment_17957", "id": "reaction_10525074", "reactome": "R-CEL-446188", "name": "ALG3 transfers Man to N-glycan precursor (GlcNAc)2 (Man)5 (PP-Dol)1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449229", "species_449298" ], "products": [ "species_449311", "species_449315" ], "modifiers": [ [ "species_10525066", "catalyst" ], [ "species_10525072", "catalyst" ] ], "additional_components": [ "WBGene00010720", "WBGene00018181" ] }, "reaction_10525091": { "compartment": "compartment_12045", "id": "reaction_10525091", "reactome": "R-CEL-446191", "name": "Addition of N-acetyl-D-glucosamine to Dolichyl phosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_162756", "species_449299" ], "products": [ "species_109402", "species_449222" ], "modifiers": [ [ "species_10525088", "catalyst" ] ], "additional_components": [ "WBGene00013362" ] }, "reaction_10525107": { "compartment": "compartment_17957", "id": "reaction_10525107", "reactome": "R-CEL-446198", "name": "ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449229", "species_449312" ], "products": [ "species_449311", "species_449365" ], "modifiers": [ [ "species_10525104", "catalyst" ], [ "species_10525072", "catalyst" ] ], "additional_components": [ "WBGene00022629", "WBGene00018181" ] }, "reaction_10525127": { "compartment": "compartment_17957", "id": "reaction_10525127", "reactome": "R-CEL-446202", "name": "Addition of the first glucose to the N-glycan precursor by ALG6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449371", "species_532542" ], "products": [ "species_449311", "species_449649" ], "modifiers": [ [ "species_10525124", "catalyst" ] ], "additional_components": [ "WBGene00007435" ] }, "reaction_10525160": { "compartment": "compartment_12045", "id": "reaction_10525160", "reactome": "R-CEL-446208", "name": "Addition of a second mannose to the N-glycan precursor by ALG2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_162860", "species_449283" ], "products": [ "species_449737", "species_29420" ], "modifiers": [ [ "species_10525157", "catalyst" ] ], "additional_components": [ "WBGene00017282" ] }, "reaction_10525176": { "compartment": "compartment_17957", "id": "reaction_10525176", "reactome": "R-CEL-446215", "name": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)6 (PP-Dol)1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449229", "species_449315" ], "products": [ "species_449311", "species_449312" ], "modifiers": [ [ "species_10525173", "catalyst" ], [ "species_10525072", "catalyst" ] ], "additional_components": [ "WBGene00007556", "WBGene00018181" ] }, "reaction_10525178": { "compartment": "compartment_17957", "id": "reaction_10525178", "reactome": "R-CEL-446216", "name": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)8 (PP-Dol)1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449229", "species_449365" ], "products": [ "species_449371", "species_449311" ], "modifiers": [ [ "species_10525173", "catalyst" ], [ "species_10525072", "catalyst" ] ], "additional_components": [ "WBGene00007556", "WBGene00018181" ] }, "reaction_10525083": { "compartment": "compartment_17957", "id": "reaction_10525083", "reactome": "R-CEL-446189", "name": "Addition of a second glucose to the N-glycan precursor by ALG8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449649", "species_532542" ], "products": [ "species_449311", "species_449638" ], "modifiers": [ [ "species_10525080", "catalyst" ] ], "additional_components": [ "WBGene00007464" ] }, "reaction_10565708": { "compartment": "compartment_984", "id": "reaction_10565708", "reactome": "R-CEL-8855711", "name": "PALM-C36-ASGR1:PALM-C54,58-ASGR2 binds desialated glycoproteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8855720", "species_10565704" ], "products": [ "species_10565706" ], "modifiers": [], "additional_components": [ "O18076", "WBGene00011668", "Q9N4W4", "WBGene00021602", "O44871", "WBGene00019914", "Q9N4W5", "WBGene00021603", "P91214", "WBGene00017199", "Q21146", "WBGene00019328", "O18076", "WBGene00011668", "Q9N4W4", "WBGene00021602", "O44871", "WBGene00019914", "Q9N4W5", "WBGene00021603", "P91214", "WBGene00017199", "Q21146", "WBGene00019328", "species_8855720" ] }, "reaction_10510086": { "compartment": "compartment_17957", "id": "reaction_10510086", "reactome": "R-CEL-162683", "name": "glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_75967", "species_8855661" ], "products": [ "species_8855666", "species_76194" ], "modifiers": [ [ "species_10510083", "catalyst" ] ], "additional_components": [ "WBGene00022447" ] }, "reaction_10510118": { "compartment": "compartment_12045", "id": "reaction_10510118", "reactome": "R-CEL-162873", "name": "(ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449229", "species_8855663" ], "products": [ "species_162872", "species_8855667" ], "modifiers": [ [ "species_10510115", "catalyst" ] ], "additional_components": [ "WBGene00020375" ] }, "reaction_10510102": { "compartment": "compartment_12045", "id": "reaction_10510102", "reactome": "R-CEL-162821", "name": "mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449229", "species_8855667" ], "products": [ "species_8855656", "species_162872" ], "modifiers": [ [ "species_10510099", "catalyst" ] ], "additional_components": [ "WBGene00194986" ] }, "reaction_10510110": { "compartment": "compartment_70101", "id": "reaction_10510110", "reactome": "R-CEL-162857", "name": "N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8855657", "species_29356" ], "products": [ "species_8855661", "species_29416" ], "modifiers": [ [ "species_10510107", "catalyst" ] ], "additional_components": [ "WBGene00013131" ] }, "reaction_10510094": { "compartment": "compartment_12045", "id": "reaction_10510094", "reactome": "R-CEL-162798", "name": "mannose(a1-4)glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose(al1-4)glucosaminyl-acyl-PI + diacylglycerol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8855659", "species_1500581" ], "products": [ "species_8855663", "species_1500596" ], "modifiers": [ [ "species_10510091", "catalyst" ] ], "additional_components": [ "WBGene00021840" ] }, "reaction_10569975": { "compartment": "compartment_70101", "id": "reaction_10569975", "reactome": "R-CEL-8955241", "name": "CAND1 binds cytosolic CRL E3 ubiquitin ligases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10556809", "species_10569971" ], "products": [ "species_10569973" ], "modifiers": [], "additional_components": [ "WBGene00013606", "G5ECR7", "WBGene00001235", "Q23457", "WBGene00004320", "Q17390", "WBGene00000837", "Q19213", "WBGene00006922", "P17221", "WBGene00001411", "Q9BKS1", "WBGene00001236", "O61795", "WBGene00020030", "Q20183", "WBGene00006415", "A0PD34", "WBGene00014848", "O62200", "WBGene00014848", "Q03607", "WBGene00014848", "G5ED84", "WBGene00020952", "Q21854", "WBGene00006493", "G5EGS4", "WBGene00002184", "Q17391", "WBGene00000838", "Q94251", "WBGene00001089", "Q17531", "WBGene00007206", "Q17962", "WBGene00007574", "O17324", "WBGene00015673", "Q20367", "WBGene00005013", "Q9GYI0", "WBGene00017920", "O45323", "WBGene00008439", "P34284", "WBGene00015350", "Q6A590", "WBGene00020884", "G5EES6", "WBGene00007333", "Q9N3G1", "WBGene00021815", "Q22071", "WBGene00003177", "G5ECU1", "WBGene00004807", "Q17389", "WBGene00000836", "Q93349", "WBGene00007985", "O45498", "WBGene00009556", "Q965N7", "WBGene00021596", "Q965N6", "WBGene00021597", "G5EFS1", "WBGene00002069", "Q9BL53", "WBGene00022139", "Q9GRV5", "WBGene00006616", "Q23595", "WBGene00014077", "A0A0K3AV89", "Y32G9A.6d", "G5EBJ4", "WBGene00013835", "O18152", "WBGene00012124", "Q9GYM5", "WBGene00019782", "Q23639", "WBGene00000840", "P91404", "WBGene00019993", "G5ECR7", "WBGene00001235", "Q23457", "WBGene00004320", "Q17390", "WBGene00000837", "Q19213", "WBGene00006922", "P17221", "WBGene00001411", "Q9BKS1", "WBGene00001236", "O61795", "WBGene00020030", "Q20183", "WBGene00006415", "A0PD34", "WBGene00014848", "O62200", "WBGene00014848", "Q03607", "WBGene00014848", "G5ED84", "WBGene00020952", "Q21854", "WBGene00006493", "G5EGS4", "WBGene00002184", "Q17391", "WBGene00000838", "Q94251", "WBGene00001089", "Q17531", "WBGene00007206", "Q17962", "WBGene00007574", "O17324", "WBGene00015673", "Q20367", "WBGene00005013", "Q9GYI0", "WBGene00017920", "O45323", "WBGene00008439", "P34284", "WBGene00015350", "Q6A590", "WBGene00020884", "G5EES6", "WBGene00007333", "Q9N3G1", "WBGene00021815", "Q22071", "WBGene00003177", "G5ECU1", "WBGene00004807", "Q17389", "WBGene00000836", "Q93349", "WBGene00007985", "O45498", "WBGene00009556", "Q965N7", "WBGene00021596", "Q965N6", "WBGene00021597", "G5EFS1", "WBGene00002069", "Q9BL53", "WBGene00022139", "Q9GRV5", "WBGene00006616", "Q23595", "WBGene00014077", "A0A0K3AV89", "Y32G9A.6d", "G5EBJ4", "WBGene00013835", "O18152", "WBGene00012124", "Q9GYM5", "WBGene00019782", "Q23639", "WBGene00000840", "P91404", "WBGene00019993", "G5ED41", "WBGene00013606" ] }, "reaction_10569046": { "compartment": "compartment_70101", "id": "reaction_10569046", "reactome": "R-CEL-8951644", "name": "Release of mature NEDD8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10556648" ], "products": [ "species_10556637", "species_10556646" ], "modifiers": [], "additional_components": [ "Q93725", "WBGene00003587", "Q9UAV3", "WBGene00006721", "Q86FN3", "WBGene00006738", "Q9UAV3", "WBGene00006721", "Q86FN3", "WBGene00006738", "WBGene00003587" ] }, "reaction_10570089": { "compartment": "compartment_7660", "id": "reaction_10570089", "reactome": "R-CEL-8956045", "name": "COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10570082" ], "products": [ "species_10570086", "species_10570084" ], "modifiers": [ [ "species_10556775", "catalyst" ] ], "additional_components": [ "Q21554", "WBGene00010890", "Q23457", "WBGene00004320", "Q965F9", "WBGene00003917", "Q18963", "WBGene00008403", "Q93759", "WBGene00009976", "Q22059", "WBGene00011318", "Q4W5Q8", "WBGene00044440", "Q09309", "WBGene00017683", "Q21934", "WBGene00011242", "Q23494", "WBGene00022742", "P90916", "WBGene00003036", "P90917", "WBGene00004312", "P90794", "WBGene00008419", "Q17963", "WBGene00006474", "Q09392", "WBGene00018564", "Q93725", "WBGene00003587", "Q17392", "WBGene00000839", "Q7JP60", "WBGene00019959", "Q7JP60", "WBGene00019959", "Q21554", "WBGene00010890", "Q23457", "WBGene00004320", "Q965F9", "WBGene00003917", "Q18963", "WBGene00008403", "Q93759", "WBGene00009976", "Q22059", "WBGene00011318", "Q4W5Q8", "WBGene00044440", "Q09309", "WBGene00017683", "Q21934", "WBGene00011242", "Q23494", "WBGene00022742", "P90916", "WBGene00003036", "P90917", "WBGene00004312", "P90794", "WBGene00008419", "Q17963", "WBGene00006474", "Q09392", "WBGene00018564", "Q17392", "WBGene00000839", "WBGene00003587", "Q9GS00", "WBGene00000813", "Q9N359", "WBGene00000816", "P91001", "WBGene00000817", "O01422", "WBGene00000814", "Q9N425", "WBGene00000815", "Q95PZ0", "WBGene00000818" ] }, "reaction_10570104": { "compartment": "compartment_70101", "id": "reaction_10570104", "reactome": "R-CEL-8956106", "name": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10532188", "species_10570093" ], "products": [ "species_10532186", "species_10570097" ], "modifiers": [ [ "species_10570093", "catalyst" ], [ "species_10570102", "inhibitor" ] ], "additional_components": [ "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "P35129", "WBGene00002344", "P91853", "WBGene00006732", "Q17720", "WBGene00006717", "Q20617", "WBGene00006719", "G5EGD2", "WBGene00001851", "Q17390", "WBGene00000837", "Q93725", "WBGene00003587", "Q7JP60", "WBGene00019959", "G5ECR7", "WBGene00001235", "Q19213", "WBGene00006922", "Q9BKS1", "WBGene00001236", "Q23457", "WBGene00004320", "P35129", "WBGene00002344", "P91853", "WBGene00006732", "Q17720", "WBGene00006717", "Q20617", "WBGene00006719", "Q17390", "WBGene00000837", "Q93725", "WBGene00003587", "Q7JP60", "WBGene00019959", "G5ECR7", "WBGene00001235", "Q19213", "WBGene00006922", "Q9BKS1", "WBGene00001236", "Q23457", "WBGene00004320", "G5EGD2", "WBGene00001851", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "G5EGD2", "WBGene00001851", "Q17390", "WBGene00000837", "Q93725", "WBGene00003587", "Q7JP60", "WBGene00019959", "G5ECR7", "WBGene00001235", "Q19213", "WBGene00006922", "Q9BKS1", "WBGene00001236", "Q23457", "WBGene00004320", "Q17390", "WBGene00000837", "Q93725", "WBGene00003587", "Q7JP60", "WBGene00019959", "G5ECR7", "WBGene00001235", "Q19213", "WBGene00006922", "Q9BKS1", "WBGene00001236", "Q23457", "WBGene00004320" ] }, "reaction_10569981": { "compartment": "compartment_7660", "id": "reaction_10569981", "reactome": "R-CEL-8955245", "name": "CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10569752", "species_10569977" ], "products": [ "species_10569979" ], "modifiers": [], "additional_components": [ "Q21554", "WBGene00010890", "Q23457", "WBGene00004320", "Q965F9", "WBGene00003917", "Q18963", "WBGene00008403", "Q93759", "WBGene00009976", "Q22059", "WBGene00011318", "Q4W5Q8", "WBGene00044440", "Q09309", "WBGene00017683", "Q21934", "WBGene00011242", "Q23494", "WBGene00022742", "P90916", "WBGene00003036", "P90917", "WBGene00004312", "P90794", "WBGene00008419", "Q17963", "WBGene00006474", "Q09392", "WBGene00018564", "Q17392", "WBGene00000839", "WBGene00013606", "G5ED41", "WBGene00013606", "Q21554", "WBGene00010890", "Q23457", "WBGene00004320", "Q965F9", "WBGene00003917", "Q18963", "WBGene00008403", "Q93759", "WBGene00009976", "Q22059", "WBGene00011318", "Q4W5Q8", "WBGene00044440", "Q09309", "WBGene00017683", "Q21934", "WBGene00011242", "Q23494", "WBGene00022742", "P90916", "WBGene00003036", "P90917", "WBGene00004312", "P90794", "WBGene00008419", "Q17963", "WBGene00006474", "Q09392", "WBGene00018564", "Q17392", "WBGene00000839" ] }, "reaction_10570060": { "compartment": "compartment_70101", "id": "reaction_10570060", "reactome": "R-CEL-8956040", "name": "COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10570047" ], "products": [ "species_10570057", "species_10556646" ], "modifiers": [ [ "species_10566026", "catalyst" ] ], "additional_components": [ "Q7JP60", "WBGene00019959", "O61795", "WBGene00020030", "Q20183", "WBGene00006415", "A0PD34", "WBGene00014848", "O62200", "WBGene00014848", "Q03607", "WBGene00014848", "G5ED84", "WBGene00020952", "Q21854", "WBGene00006493", "G5EGS4", "WBGene00002184", "Q23457", "WBGene00004320", "Q17391", "WBGene00000838", "Q93725", "WBGene00003587", "G5ECR7", "WBGene00001235", "Q17390", "WBGene00000837", "Q9BKS1", "WBGene00001236", "Q19213", "WBGene00006922", "P17221", "WBGene00001411", "Q94251", "WBGene00001089", "Q17531", "WBGene00007206", "Q17962", "WBGene00007574", "O17324", "WBGene00015673", "Q20367", "WBGene00005013", "Q9GYI0", "WBGene00017920", "O45323", "WBGene00008439", "P34284", "WBGene00015350", "Q6A590", "WBGene00020884", "G5EES6", "WBGene00007333", "Q9N3G1", "WBGene00021815", "Q22071", "WBGene00003177", "Q17389", "WBGene00000836", "G5ECU1", "WBGene00004807", "Q9U3C8", "WBGene00010428", "Q93349", "WBGene00007985", "O45498", "WBGene00009556", "Q965N7", "WBGene00021596", "Q965N6", "WBGene00021597", "G5EFS1", "WBGene00002069", "Q9BL53", "WBGene00022139", "Q9GRV5", "WBGene00006616", "Q23595", "WBGene00014077", "A0A0K3AV89", "Y32G9A.6d", "G5EBJ4", "WBGene00013835", "O18152", "WBGene00012124", "Q9GYM5", "WBGene00019782", "Q23639", "WBGene00000840", "P91404", "WBGene00019993", "Q94251", "WBGene00001089", "Q17531", "WBGene00007206", "Q17962", "WBGene00007574", "O17324", "WBGene00015673", "Q20367", "WBGene00005013", "Q9GYI0", "WBGene00017920", "O45323", "WBGene00008439", "P34284", "WBGene00015350", "Q6A590", "WBGene00020884", "G5EES6", "WBGene00007333", "Q9N3G1", "WBGene00021815", "Q22071", "WBGene00003177", "G5ECU1", "WBGene00004807", "Q17389", "WBGene00000836", "Q23457", "WBGene00004320", "Q7JP60", "WBGene00019959", "Q9U3C8", "WBGene00010428", "G5ECR7", "WBGene00001235", "Q17390", "WBGene00000837", "Q19213", "WBGene00006922", "P17221", "WBGene00001411", "Q9BKS1", "WBGene00001236", "O61795", "WBGene00020030", "Q20183", "WBGene00006415", "A0PD34", "WBGene00014848", "O62200", "WBGene00014848", "Q03607", "WBGene00014848", "G5ED84", "WBGene00020952", "Q21854", "WBGene00006493", "G5EGS4", "WBGene00002184", "Q17391", "WBGene00000838", "Q93349", "WBGene00007985", "O45498", "WBGene00009556", "Q965N7", "WBGene00021596", "Q965N6", "WBGene00021597", "G5EFS1", "WBGene00002069", "Q9BL53", "WBGene00022139", "Q9GRV5", "WBGene00006616", "Q23595", "WBGene00014077", "A0A0K3AV89", "Y32G9A.6d", "G5EBJ4", "WBGene00013835", "O18152", "WBGene00012124", "Q9GYM5", "WBGene00019782", "Q23639", "WBGene00000840", "P91404", "WBGene00019993", "WBGene00003587", "Q9N359", "WBGene00000816", "P91001", "WBGene00000817", "Q95PZ0", "WBGene00000818", "Q9GS00", "WBGene00000813", "O01422", "WBGene00000814", "Q9N425", "WBGene00000815" ] }, "reaction_10570095": { "compartment": "compartment_70101", "id": "reaction_10570095", "reactome": "R-CEL-8956103", "name": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds hydroxyprolyl-HIF-alpha", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10570091", "species_10532134" ], "products": [ "species_10570093" ], "modifiers": [], "additional_components": [ "Q17390", "WBGene00000837", "Q93725", "WBGene00003587", "Q7JP60", "WBGene00019959", "G5ECR7", "WBGene00001235", "Q19213", "WBGene00006922", "Q9BKS1", "WBGene00001236", "Q23457", "WBGene00004320", "WBGene00001851", "G5EGD2", "WBGene00001851", "Q17390", "WBGene00000837", "Q93725", "WBGene00003587", "Q7JP60", "WBGene00019959", "G5ECR7", "WBGene00001235", "Q19213", "WBGene00006922", "Q9BKS1", "WBGene00001236", "Q23457", "WBGene00004320" ] }, "reaction_10520016": { "compartment": "compartment_70101", "id": "reaction_10520016", "reactome": "R-CEL-381111", "name": "EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10505631", "species_113592" ], "products": [ "species_10520013", "species_29370" ], "modifiers": [ [ "species_10519989", "catalyst" ] ], "additional_components": [ "Q9BKU3", "WBGene00021351", "Q21230", "WBGene00010560", "Q95XR0", "WBGene00021466", "Q21230", "WBGene00010560", "Q9BKU3", "WBGene00021351", "Q95XR0", "WBGene00021466", "Q19192", "WBGene00003970" ] }, "reaction_10519991": { "compartment": "compartment_12045", "id": "reaction_10519991", "reactome": "R-CEL-381087", "name": "Dimerization of PERK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10519980" ], "products": [ "species_10519989" ], "modifiers": [], "additional_components": [ "WBGene00003970", "Q19192", "WBGene00003970" ] }, "reaction_10520006": { "compartment": "compartment_12045", "id": "reaction_10520006", "reactome": "R-CEL-381091", "name": "IRE1 dimer autophosphorylates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10519998", "species_113592" ], "products": [ "species_29370", "species_10520003" ], "modifiers": [ [ "species_10519998", "catalyst" ] ], "additional_components": [ "Q09499", "WBGene00002147", "Q09499", "WBGene00002147", "Q09499", "WBGene00002147" ] }, "reaction_10520008": { "compartment": "compartment_12045", "id": "reaction_10520008", "reactome": "R-CEL-381109", "name": "IRE1 binds IRE1 forming dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10519996" ], "products": [ "species_10519998" ], "modifiers": [], "additional_components": [ "WBGene00002147", "Q09499", "WBGene00002147" ] }, "reaction_10567201": { "compartment": "compartment_20699", "id": "reaction_10567201", "reactome": "R-CEL-8874208", "name": "CREB3L3 translocates from the endoplasmic reticulum membrane to the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10567199" ], "products": [ "species_10567195" ], "modifiers": [], "additional_components": [ "WBGene00002783", "WBGene00002783" ] }, "reaction_10567187": { "compartment": "compartment_7660", "id": "reaction_10567187", "reactome": "R-CEL-8874202", "name": "CREB3L3 translocates from the cytosol to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10567179" ], "products": [ "species_10567185" ], "modifiers": [], "additional_components": [ "WBGene00002783", "WBGene00002783" ] }, "reaction_10567183": { "compartment": "compartment_20699", "id": "reaction_10567183", "reactome": "R-CEL-8874201", "name": "MBTPS2 (S2P) cleaves CREB3L3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10567177" ], "products": [ "species_10567181", "species_10567179" ], "modifiers": [ [ "species_10522008", "catalyst" ] ], "additional_components": [ "WBGene00002783", "WBGene00002783", "WBGene00002783", "WBGene00013225" ] }, "reaction_10519975": { "compartment": "compartment_70101", "id": "reaction_10519975", "reactome": "R-CEL-381026", "name": "ATF6 (ATF6-alpha) translocates from the cytosol to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10519971" ], "products": [ "species_10519973" ], "modifiers": [], "additional_components": [ "WBGene00000222", "WBGene00000222" ] }, "reaction_10522011": { "compartment": "compartment_20699", "id": "reaction_10522011", "reactome": "R-CEL-420818", "name": "MBTPS2 (S2P) cleaves ATF6 (ATF6-alpha)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10520023" ], "products": [ "species_10522003", "species_10519971" ], "modifiers": [ [ "species_10522008", "catalyst" ] ], "additional_components": [ "WBGene00000222", "WBGene00000222", "WBGene00000222", "WBGene00013225" ] }, "reaction_10520031": { "compartment": "compartment_12045", "id": "reaction_10520031", "reactome": "R-CEL-381186", "name": "ATF6 (ATF6-alpha) translocates from the endoplasmic reticulum to the Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10520027" ], "products": [ "species_10520021" ], "modifiers": [], "additional_components": [ "WBGene00000222", "WBGene00000222" ] }, "reaction_10517698": { "compartment": "compartment_876", "id": "reaction_10517698", "reactome": "R-CEL-265177", "name": "Exocyst complex formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10517679", "species_10517694", "species_10517659", "species_10517674", "species_10517689", "species_10517669", "species_10517684", "species_10517664" ], "products": [ "species_10517696" ], "modifiers": [], "additional_components": [ "WBGene00013687", "WBGene00016606", "WBGene00004753", "WBGene00016188", "WBGene00017284", "WBGene00016376", "WBGene00018703", "WBGene00004752", "Q22706", "WBGene00004752", "Q20678", "WBGene00018703", "Q18406", "WBGene00016376", "Q19262", "WBGene00017284", "Q18286", "WBGene00016188", "Q9XWS2", "WBGene00004753", "P91149", "WBGene00016606", "Q95Q35", "WBGene00013687" ] }, "reaction_10555315": { "compartment": "compartment_70101", "id": "reaction_10555315", "reactome": "R-CEL-5676917", "name": "MRSBs reduce L-methyl-(R)-S-oxide to L-methionine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5676932", "species_10506160" ], "products": [ "species_10506158", "species_174390" ], "modifiers": [ [ "species_10555312", "catalyst" ] ], "additional_components": [ "WBGene00015062", "WBGene00015062", "P34436", "WBGene00018419" ] }, "reaction_10555323": { "compartment": "compartment_70101", "id": "reaction_10555323", "reactome": "R-CEL-5676966", "name": "PCMT1 transfers CH3 from AdoMet to isoAsp to form MetAsp", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5687536", "species_71284" ], "products": [ "species_5687529", "species_71285" ], "modifiers": [ [ "species_10555320", "catalyst" ] ], "additional_components": [ "WBGene00003954" ] }, "reaction_10522946": { "compartment": "compartment_876", "id": "reaction_10522946", "reactome": "R-CEL-427656", "name": "SLC34A1,2 cotransports Pi, 3Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109277", "species_74113" ], "products": [ "species_29372", "species_83910" ], "modifiers": [ [ "species_10522943", "catalyst" ] ], "additional_components": [ "WBGene00022767" ] }, "reaction_10555765": { "compartment": "compartment_3828046", "id": "reaction_10555765", "reactome": "R-CEL-5684864", "name": "NAPSA, CTSH, PGA3-5 cleave pro-SFTPB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10555678", "species_5685882" ], "products": [ "species_10555690", "species_10555684", "species_10555696" ], "modifiers": [ [ "species_10555762", "catalyst" ] ], "additional_components": [ "Q18276", "WBGene00004995", "Q18279", "WBGene00004993", "Q18276", "WBGene00004995", "Q18279", "WBGene00004993", "Q18276", "WBGene00004995", "Q18279", "WBGene00004993", "Q18276", "WBGene00004995", "Q18279", "WBGene00004993", "Q18020", "WBGene00007605", "Q21966", "WBGene00000217", "Q22972", "WBGene00017881", "Q7JKL9", "WBGene00013973", "Q86NE0", "WBGene00000215", "Q8MYN5", "WBGene00012683", "Q8MYN6", "WBGene00012682", "Q8MYN7", "WBGene00012681", "G5EC01", "WBGene00077655", "G5EEI4", "WBGene00000214", "O01530", "WBGene00000219", "O01531", "WBGene00017678", "O01532", "WBGene00000218", "O45072", "WBGene00015700", "P55956", "WBGene00000216" ] }, "reaction_10555575": { "compartment": "compartment_2133233", "id": "reaction_10555575", "reactome": "R-CEL-5683714", "name": "ABCA3 transports PC, PG from ER membrane to lamellar body", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_5684863" ], "products": [ "species_29372", "species_29370", "species_5684869" ], "modifiers": [ [ "species_10555572", "catalyst" ] ], "additional_components": [ "species_194276", "species_1524042", "species_194276", "species_1524042", "WBGene00000022" ] }, "reaction_10558534": { "compartment": "compartment_3828046", "id": "reaction_10558534", "reactome": "R-CEL-6791016", "name": "SFTPB binds itself", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10555684" ], "products": [ "species_10555767" ], "modifiers": [], "additional_components": [ "Q18276", "WBGene00004995", "Q18279", "WBGene00004993", "Q18276", "WBGene00004995", "Q18279", "WBGene00004993" ] }, "reaction_10572265": { "compartment": "compartment_12045", "id": "reaction_10572265", "reactome": "R-CEL-9624789", "name": "pro-SFTPB translocates from ER membrane to multivesicle body", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10572263" ], "products": [ "species_10555678" ], "modifiers": [], "additional_components": [ "Q18276", "WBGene00004995", "Q18279", "WBGene00004993", "Q18276", "WBGene00004995", "Q18279", "WBGene00004993" ] }, "reaction_10509923": { "compartment": "compartment_70101", "id": "reaction_10509923", "reactome": "R-CEL-156930", "name": "GTP-binding activates eEF2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509919", "species_29438" ], "products": [ "species_10509921" ], "modifiers": [], "additional_components": [ "WBGene00001167", "species_29438", "P29691", "WBGene00001167" ] }, "reaction_10505689": { "compartment": "compartment_70101", "id": "reaction_10505689", "reactome": "R-CEL-72631", "name": "Formation of the cap-binding eIF4F complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10505660", "species_10505655", "species_10505665" ], "products": [ "species_10505667" ], "modifiers": [], "additional_components": [ "WBGene00002061", "Q20935", "WBGene00018997", "P27639", "WBGene00002083", "WBGene00002066", "A0A486WX07", "WBGene00002066", "Q20935", "WBGene00018997", "P27639", "WBGene00002083", "O61955", "WBGene00002061" ] }, "reaction_10505697": { "compartment": "compartment_70101", "id": "reaction_10505697", "reactome": "R-CEL-72669", "name": "Met-tRNAi binds to eIF2:GTP to form the ternary complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_72393", "species_10505633" ], "products": [ "species_10505635" ], "modifiers": [ [ "species_29438", "catalyst" ] ], "additional_components": [ "species_29438", "Q9BKU3", "WBGene00021351", "Q21230", "WBGene00010560", "Q95XR0", "WBGene00021466", "species_29438", "Q9BKU3", "WBGene00021351", "Q21230", "WBGene00010560", "Q95XR0", "WBGene00021466" ] }, "reaction_10505997": { "compartment": "compartment_70101", "id": "reaction_10505997", "reactome": "R-CEL-72691", "name": "Formation of the 43S pre-initiation complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10505993", "species_10505635" ], "products": [ "species_10505637" ], "modifiers": [], "additional_components": [ "P51403", "WBGene00004471", "Q9NEN6", "WBGene00004475", "Q8WQA8", "WBGene00004489", "Q23312", "WBGene00004476", "O01869", "WBGene00004479", "P49197", "WBGene00004490", "P48156", "WBGene00004477", "Q20206", "WBGene00004480", "Q19877", "WBGene00004492", "Q20228", "WBGene00004478", "P49196", "WBGene00004481", "Q1XFY9", "WBGene00004493", "P46769", "WBGene00004469", "P51404", "WBGene00004482", "P52821", "WBGene00004494", "Q9TXP0", "WBGene00004496", "P48150", "WBGene00004483", "O45499", "WBGene00004495", "Q9N3X2", "WBGene00004473", "Q9XVP0", "WBGene00004484", "Q95Y04", "WBGene00004497", "Q22054", "WBGene00004485", "P90983", "WBGene00004498", "O01692", "WBGene00004486", "P48152", "WBGene00004472", "O18240", "WBGene00004487", "O18650", "WBGene00004488", "P48154", "WBGene00004470", "O17218", "WBGene00004491", "P49041", "WBGene00004474", "Q95QW0", "WBGene00015920", "O01974", "WBGene00001231", "Q94261", "WBGene00019543", "P34339", "WBGene00001209", "Q9XWP7", "WBGene00012738", "P30642", "WBGene00001227", "Q965S8", "WBGene00001232", "O02328", "WBGene00001226", "Q19706", "WBGene00001230", "O61820", "WBGene00001228", "Q18967", "WBGene00001229", "Q9XUP3", "WBGene00001233", "Q9XWI6", "WBGene00001225", "Q9TXU7", "WBGene00019162", "species_29438", "Q9BKU3", "WBGene00021351", "Q21230", "WBGene00010560", "Q95XR0", "WBGene00021466", "species_29438", "Q9BKU3", "WBGene00021351", "Q21230", "WBGene00010560", "Q95XR0", "WBGene00021466", "P51403", "WBGene00004471", "Q9NEN6", "WBGene00004475", "Q8WQA8", "WBGene00004489", "Q23312", "WBGene00004476", "O01869", "WBGene00004479", "P49197", "WBGene00004490", "P48156", "WBGene00004477", "Q20206", "WBGene00004480", "Q19877", "WBGene00004492", "Q20228", "WBGene00004478", "P49196", "WBGene00004481", "Q1XFY9", "WBGene00004493", "P46769", "WBGene00004469", "P51404", "WBGene00004482", "P52821", "WBGene00004494", "Q9TXP0", "WBGene00004496", "P48150", "WBGene00004483", "O45499", "WBGene00004495", "Q9N3X2", "WBGene00004473", "Q9XVP0", "WBGene00004484", "Q95Y04", "WBGene00004497", "Q22054", "WBGene00004485", "P90983", "WBGene00004498", "O01692", "WBGene00004486", "P48152", "WBGene00004472", "O18240", "WBGene00004487", "O18650", "WBGene00004488", "P48154", "WBGene00004470", "O17218", "WBGene00004491", "P49041", "WBGene00004474", "Q95QW0", "WBGene00015920", "O01974", "WBGene00001231", "Q94261", "WBGene00019543", "P34339", "WBGene00001209", "Q9XWP7", "WBGene00012738", "P30642", "WBGene00001227", "Q965S8", "WBGene00001232", "O02328", "WBGene00001226", "Q19706", "WBGene00001230", "O61820", "WBGene00001228", "Q18967", "WBGene00001229", "Q9XUP3", "WBGene00001233", "Q9XWI6", "WBGene00001225", "Q9TXU7", "WBGene00019162" ] }, "reaction_10505695": { "compartment": "compartment_70101", "id": "reaction_10505695", "reactome": "R-CEL-72663", "name": "De novo formation of eIF2:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10505631", "species_29438" ], "products": [ "species_10505633" ], "modifiers": [], "additional_components": [ "Q9BKU3", "WBGene00021351", "Q21230", "WBGene00010560", "Q95XR0", "WBGene00021466", "species_29438", "Q9BKU3", "WBGene00021351", "Q21230", "WBGene00010560", "Q95XR0", "WBGene00021466" ] }, "reaction_10505987": { "compartment": "compartment_70101", "id": "reaction_10505987", "reactome": "R-CEL-72671", "name": "eIF5B:GTP is hydrolyzed and released", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10505981" ], "products": [ "species_10505983", "species_29372", "species_10505985" ], "modifiers": [], "additional_components": [ "P91914", "WBGene00004441", "Q19869", "WBGene00004440", "O01868", "WBGene00004436", "P48162", "WBGene00004438", "P52819", "WBGene00004434", "P48158", "WBGene00004435", "Q09533", "WBGene00004421", "P34334", "WBGene00004433", "O02639", "WBGene00004431", "Q95Y90", "WBGene00004420", "O44480", "WBGene00004432", "Q22716", "WBGene00004446", "Q9U332", "WBGene00004445", "Q9XWS4", "WBGene00004444", "P52814", "WBGene00004453", "O45226", "WBGene00004443", "Q21930", "WBGene00004442", "P48166", "WBGene00004454", "Q9BKU5", "WBGene00021350", "P50880", "WBGene00004414", "P61866", "WBGene00004424", "O17570", "WBGene00004452", "Q19162", "WBGene00004423", "Q9U2A8", "WBGene00004456", "Q9N4I4", "WBGene00004412", "O62388", "WBGene00012179", "O01504", "WBGene00016493", "P49181", "WBGene00004450", "P91913", "WBGene00004409", "P49180", "WBGene00004447", "Q93572", "WBGene00004408", "P34662", "WBGene00004449", "Q9XVF7", "WBGene00004413", "O45946", "WBGene00004430", "Q966C6", "WBGene00004419", "Q9BL19", "WBGene00004429", "O01802", "WBGene00004418", "P91374", "WBGene00004427", "P47991", "WBGene00004417", "Q9XVE9", "WBGene00004426", "P49405", "WBGene00004416", "Q27389", "WBGene00004428", "P37165", "WBGene00006725", "P91128", "WBGene00004425", "O02056", "WBGene00004415", "P51403", "WBGene00004471", "Q9NEN6", "WBGene00004475", "Q8WQA8", "WBGene00004489", "Q23312", "WBGene00004476", "O01869", "WBGene00004479", "P49197", "WBGene00004490", "P48156", "WBGene00004477", "Q20206", "WBGene00004480", "Q19877", "WBGene00004492", "Q20228", "WBGene00004478", "P49196", "WBGene00004481", "Q1XFY9", "WBGene00004493", "P46769", "WBGene00004469", "P51404", "WBGene00004482", "P52821", "WBGene00004494", "Q9TXP0", "WBGene00004496", "P48150", "WBGene00004483", "O45499", "WBGene00004495", "Q9N3X2", "WBGene00004473", "Q9XVP0", "WBGene00004484", "Q95Y04", "WBGene00004497", "Q22054", "WBGene00004485", "P90983", "WBGene00004498", "O01692", "WBGene00004486", "P48152", "WBGene00004472", "O18240", "WBGene00004487", "O18650", "WBGene00004488", "P48154", "WBGene00004470", "O17218", "WBGene00004491", "P49041", "WBGene00004474", "G5EGT7", "WBGene00021857", "species_29438", "G5EGT7", "WBGene00021857", "species_29420", "P91914", "WBGene00004441", "Q19869", "WBGene00004440", "O01868", "WBGene00004436", "P48162", "WBGene00004438", "P52819", "WBGene00004434", "P48158", "WBGene00004435", "Q09533", "WBGene00004421", "P34334", "WBGene00004433", "O02639", "WBGene00004431", "Q95Y90", "WBGene00004420", "O44480", "WBGene00004432", "Q22716", "WBGene00004446", "Q9U332", "WBGene00004445", "Q9XWS4", "WBGene00004444", "P52814", "WBGene00004453", "O45226", "WBGene00004443", "Q21930", "WBGene00004442", "P48166", "WBGene00004454", "Q9BKU5", "WBGene00021350", "P50880", "WBGene00004414", "P61866", "WBGene00004424", "O17570", "WBGene00004452", "Q19162", "WBGene00004423", "Q9U2A8", "WBGene00004456", "Q9N4I4", "WBGene00004412", "O62388", "WBGene00012179", "O01504", "WBGene00016493", "P49181", "WBGene00004450", "P91913", "WBGene00004409", "P49180", "WBGene00004447", "Q93572", "WBGene00004408", "P34662", "WBGene00004449", "Q9XVF7", "WBGene00004413", "O45946", "WBGene00004430", "Q966C6", "WBGene00004419", "Q9BL19", "WBGene00004429", "O01802", "WBGene00004418", "P91374", "WBGene00004427", "P47991", "WBGene00004417", "Q9XVE9", "WBGene00004426", "P49405", "WBGene00004416", "Q27389", "WBGene00004428", "P37165", "WBGene00006725", "P91128", "WBGene00004425", "O02056", "WBGene00004415", "P51403", "WBGene00004471", "Q9NEN6", "WBGene00004475", "Q8WQA8", "WBGene00004489", "Q23312", "WBGene00004476", "O01869", "WBGene00004479", "P49197", "WBGene00004490", "P48156", "WBGene00004477", "Q20206", "WBGene00004480", "Q19877", "WBGene00004492", "Q20228", "WBGene00004478", "P49196", "WBGene00004481", "Q1XFY9", "WBGene00004493", "P46769", "WBGene00004469", "P51404", "WBGene00004482", "P52821", "WBGene00004494", "Q9TXP0", "WBGene00004496", "P48150", "WBGene00004483", "O45499", "WBGene00004495", "Q9N3X2", "WBGene00004473", "Q9XVP0", "WBGene00004484", "Q95Y04", "WBGene00004497", "Q22054", "WBGene00004485", "P90983", "WBGene00004498", "O01692", "WBGene00004486", "P48152", "WBGene00004472", "O18240", "WBGene00004487", "O18650", "WBGene00004488", "P48154", "WBGene00004470", "O17218", "WBGene00004491", "P49041", "WBGene00004474" ] }, "reaction_10505989": { "compartment": "compartment_70101", "id": "reaction_10505989", "reactome": "R-CEL-72672", "name": "The 60S subunit joins the translation initiation complex ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10505979", "species_10505683", "species_10505970" ], "products": [ "species_10505981" ], "modifiers": [], "additional_components": [ "G5EGT7", "WBGene00021857", "species_29438", "P51403", "WBGene00004471", "Q9NEN6", "WBGene00004475", "Q8WQA8", "WBGene00004489", "Q23312", "WBGene00004476", "O01869", "WBGene00004479", "P49197", "WBGene00004490", "P48156", "WBGene00004477", "Q20206", "WBGene00004480", "Q19877", "WBGene00004492", "Q20228", "WBGene00004478", "P49196", "WBGene00004481", "Q1XFY9", "WBGene00004493", "P46769", "WBGene00004469", "P51404", "WBGene00004482", "P52821", "WBGene00004494", "Q9TXP0", "WBGene00004496", "P48150", "WBGene00004483", "O45499", "WBGene00004495", "Q9N3X2", "WBGene00004473", "Q9XVP0", "WBGene00004484", "Q95Y04", "WBGene00004497", "Q22054", "WBGene00004485", "P90983", "WBGene00004498", "O01692", "WBGene00004486", "P48152", "WBGene00004472", "O18240", "WBGene00004487", "O18650", "WBGene00004488", "P48154", "WBGene00004470", "O17218", "WBGene00004491", "P49041", "WBGene00004474", "P91914", "WBGene00004441", "Q19869", "WBGene00004440", "O01868", "WBGene00004436", "P48162", "WBGene00004438", "P52819", "WBGene00004434", "P48158", "WBGene00004435", "Q09533", "WBGene00004421", "P34334", "WBGene00004433", "O02639", "WBGene00004431", "Q95Y90", "WBGene00004420", "O44480", "WBGene00004432", "Q22716", "WBGene00004446", "Q9U332", "WBGene00004445", "Q9XWS4", "WBGene00004444", "P52814", "WBGene00004453", "O45226", "WBGene00004443", "Q21930", "WBGene00004442", "P48166", "WBGene00004454", "Q9BKU5", "WBGene00021350", "P50880", "WBGene00004414", "P61866", "WBGene00004424", "O17570", "WBGene00004452", "Q19162", "WBGene00004423", "Q9U2A8", "WBGene00004456", "Q9N4I4", "WBGene00004412", "O62388", "WBGene00012179", "O01504", "WBGene00016493", "P49181", "WBGene00004450", "P91913", "WBGene00004409", "P49180", "WBGene00004447", "Q93572", "WBGene00004408", "P34662", "WBGene00004449", "Q9XVF7", "WBGene00004413", "O45946", "WBGene00004430", "Q966C6", "WBGene00004419", "Q9BL19", "WBGene00004429", "O01802", "WBGene00004418", "P91374", "WBGene00004427", "P47991", "WBGene00004417", "Q9XVE9", "WBGene00004426", "P49405", "WBGene00004416", "Q27389", "WBGene00004428", "P37165", "WBGene00006725", "P91128", "WBGene00004425", "O02056", "WBGene00004415", "P91914", "WBGene00004441", "Q19869", "WBGene00004440", "O01868", "WBGene00004436", "P48162", "WBGene00004438", "P52819", "WBGene00004434", "P48158", "WBGene00004435", "Q09533", "WBGene00004421", "P34334", "WBGene00004433", "O02639", "WBGene00004431", "Q95Y90", "WBGene00004420", "O44480", "WBGene00004432", "Q22716", "WBGene00004446", "Q9U332", "WBGene00004445", "Q9XWS4", "WBGene00004444", "P52814", "WBGene00004453", "O45226", "WBGene00004443", "Q21930", "WBGene00004442", "P48166", "WBGene00004454", "Q9BKU5", "WBGene00021350", "P50880", "WBGene00004414", "P61866", "WBGene00004424", "O17570", "WBGene00004452", "Q19162", "WBGene00004423", "Q9U2A8", "WBGene00004456", "Q9N4I4", "WBGene00004412", "O62388", "WBGene00012179", "O01504", "WBGene00016493", "P49181", "WBGene00004450", "P91913", "WBGene00004409", "P49180", "WBGene00004447", "Q93572", "WBGene00004408", "P34662", "WBGene00004449", "Q9XVF7", "WBGene00004413", "O45946", "WBGene00004430", "Q966C6", "WBGene00004419", "Q9BL19", "WBGene00004429", "O01802", "WBGene00004418", "P91374", "WBGene00004427", "P47991", "WBGene00004417", "Q9XVE9", "WBGene00004426", "P49405", "WBGene00004416", "Q27389", "WBGene00004428", "P37165", "WBGene00006725", "P91128", "WBGene00004425", "O02056", "WBGene00004415", "P51403", "WBGene00004471", "Q9NEN6", "WBGene00004475", "Q8WQA8", "WBGene00004489", "Q23312", "WBGene00004476", "O01869", "WBGene00004479", "P49197", "WBGene00004490", "P48156", "WBGene00004477", "Q20206", "WBGene00004480", "Q19877", "WBGene00004492", "Q20228", "WBGene00004478", "P49196", "WBGene00004481", "Q1XFY9", "WBGene00004493", "P46769", "WBGene00004469", "P51404", "WBGene00004482", "P52821", "WBGene00004494", "Q9TXP0", "WBGene00004496", "P48150", "WBGene00004483", "O45499", "WBGene00004495", "Q9N3X2", "WBGene00004473", "Q9XVP0", "WBGene00004484", "Q95Y04", "WBGene00004497", "Q22054", "WBGene00004485", "P90983", "WBGene00004498", "O01692", "WBGene00004486", "P48152", "WBGene00004472", "O18240", "WBGene00004487", "O18650", "WBGene00004488", "P48154", "WBGene00004470", "O17218", "WBGene00004491", "P49041", "WBGene00004474", "G5EGT7", "WBGene00021857", "species_29438" ] }, "reaction_10505991": { "compartment": "compartment_70101", "id": "reaction_10505991", "reactome": "R-CEL-72673", "name": "Release of 40S and 60S subunits from the 80S ribosome ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10505614", "species_10505972" ], "products": [ "species_10505614", "species_10505542", "species_10505970" ], "modifiers": [], "additional_components": [ "WBGene00019162", "P91914", "WBGene00004441", "Q19869", "WBGene00004440", "O01868", "WBGene00004436", "P48162", "WBGene00004438", "P52819", "WBGene00004434", "P48158", "WBGene00004435", "Q09533", "WBGene00004421", "P34334", "WBGene00004433", "O02639", "WBGene00004431", "Q95Y90", "WBGene00004420", "O44480", "WBGene00004432", "Q22716", "WBGene00004446", "Q9U332", "WBGene00004445", "Q9XWS4", "WBGene00004444", "P52814", "WBGene00004453", "O45226", "WBGene00004443", "Q21930", "WBGene00004442", "P48166", "WBGene00004454", "Q9BKU5", "WBGene00021350", "P50880", "WBGene00004414", "P61866", "WBGene00004424", "O17570", "WBGene00004452", "Q19162", "WBGene00004423", "Q9U2A8", "WBGene00004456", "Q9N4I4", "WBGene00004412", "O62388", "WBGene00012179", "O01504", "WBGene00016493", "P49181", "WBGene00004450", "P91913", "WBGene00004409", "P49180", "WBGene00004447", "Q93572", "WBGene00004408", "P34662", "WBGene00004449", "Q9XVF7", "WBGene00004413", "O45946", "WBGene00004430", "Q966C6", "WBGene00004419", "Q9BL19", "WBGene00004429", "O01802", "WBGene00004418", "P91374", "WBGene00004427", "P47991", "WBGene00004417", "Q9XVE9", "WBGene00004426", "P49405", "WBGene00004416", "Q27389", "WBGene00004428", "P37165", "WBGene00006725", "P91128", "WBGene00004425", "O02056", "WBGene00004415", "P51403", "WBGene00004471", "Q9NEN6", "WBGene00004475", "Q8WQA8", "WBGene00004489", "Q23312", "WBGene00004476", "O01869", "WBGene00004479", "P49197", "WBGene00004490", "P48156", "WBGene00004477", "Q20206", "WBGene00004480", "Q19877", "WBGene00004492", "Q20228", "WBGene00004478", "P49196", "WBGene00004481", "Q1XFY9", "WBGene00004493", "P46769", "WBGene00004469", "P51404", "WBGene00004482", "P52821", "WBGene00004494", "Q9TXP0", "WBGene00004496", "P48150", "WBGene00004483", "O45499", "WBGene00004495", "Q9N3X2", "WBGene00004473", "Q9XVP0", "WBGene00004484", "Q95Y04", "WBGene00004497", "Q22054", "WBGene00004485", "P90983", "WBGene00004498", "O01692", "WBGene00004486", "P48152", "WBGene00004472", "O18240", "WBGene00004487", "O18650", "WBGene00004488", "P48154", "WBGene00004470", "O17218", "WBGene00004491", "P49041", "WBGene00004474", "WBGene00019162", "P51403", "WBGene00004471", "Q9NEN6", "WBGene00004475", "Q8WQA8", "WBGene00004489", "Q23312", "WBGene00004476", "O01869", "WBGene00004479", "P49197", "WBGene00004490", "P48156", "WBGene00004477", "Q20206", "WBGene00004480", "Q19877", "WBGene00004492", "Q20228", "WBGene00004478", "P49196", "WBGene00004481", "Q1XFY9", "WBGene00004493", "P46769", "WBGene00004469", "P51404", "WBGene00004482", "P52821", "WBGene00004494", "Q9TXP0", "WBGene00004496", "P48150", "WBGene00004483", "O45499", "WBGene00004495", "Q9N3X2", "WBGene00004473", "Q9XVP0", "WBGene00004484", "Q95Y04", "WBGene00004497", "Q22054", "WBGene00004485", "P90983", "WBGene00004498", "O01692", "WBGene00004486", "P48152", "WBGene00004472", "O18240", "WBGene00004487", "O18650", "WBGene00004488", "P48154", "WBGene00004470", "O17218", "WBGene00004491", "P49041", "WBGene00004474", "P91914", "WBGene00004441", "Q19869", "WBGene00004440", "O01868", "WBGene00004436", "P48162", "WBGene00004438", "P52819", "WBGene00004434", "P48158", "WBGene00004435", "Q09533", "WBGene00004421", "P34334", "WBGene00004433", "O02639", "WBGene00004431", "Q95Y90", "WBGene00004420", "O44480", "WBGene00004432", "Q22716", "WBGene00004446", "Q9U332", "WBGene00004445", "Q9XWS4", "WBGene00004444", "P52814", "WBGene00004453", "O45226", "WBGene00004443", "Q21930", "WBGene00004442", "P48166", "WBGene00004454", "Q9BKU5", "WBGene00021350", "P50880", "WBGene00004414", "P61866", "WBGene00004424", "O17570", "WBGene00004452", "Q19162", "WBGene00004423", "Q9U2A8", "WBGene00004456", "Q9N4I4", "WBGene00004412", "O62388", "WBGene00012179", "O01504", "WBGene00016493", "P49181", "WBGene00004450", "P91913", "WBGene00004409", "P49180", "WBGene00004447", "Q93572", "WBGene00004408", "P34662", "WBGene00004449", "Q9XVF7", "WBGene00004413", "O45946", "WBGene00004430", "Q966C6", "WBGene00004419", "Q9BL19", "WBGene00004429", "O01802", "WBGene00004418", "P91374", "WBGene00004427", "P47991", "WBGene00004417", "Q9XVE9", "WBGene00004426", "P49405", "WBGene00004416", "Q27389", "WBGene00004428", "P37165", "WBGene00006725", "P91128", "WBGene00004425", "O02056", "WBGene00004415" ] }, "reaction_10505995": { "compartment": "compartment_70101", "id": "reaction_10505995", "reactome": "R-CEL-72676", "name": "eIF3 and eIF1A bind to the 40S subunit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10505614", "species_10505609", "species_10505542" ], "products": [ "species_10505993" ], "modifiers": [], "additional_components": [ "WBGene00019162", "Q95QW0", "WBGene00015920", "O01974", "WBGene00001231", "Q94261", "WBGene00019543", "P34339", "WBGene00001209", "Q9XWP7", "WBGene00012738", "P30642", "WBGene00001227", "Q965S8", "WBGene00001232", "O02328", "WBGene00001226", "Q19706", "WBGene00001230", "O61820", "WBGene00001228", "Q18967", "WBGene00001229", "Q9XUP3", "WBGene00001233", "Q9XWI6", "WBGene00001225", "P51403", "WBGene00004471", "Q9NEN6", "WBGene00004475", "Q8WQA8", "WBGene00004489", "Q23312", "WBGene00004476", "O01869", "WBGene00004479", "P49197", "WBGene00004490", "P48156", "WBGene00004477", "Q20206", "WBGene00004480", "Q19877", "WBGene00004492", "Q20228", "WBGene00004478", "P49196", "WBGene00004481", "Q1XFY9", "WBGene00004493", "P46769", "WBGene00004469", "P51404", "WBGene00004482", "P52821", "WBGene00004494", "Q9TXP0", "WBGene00004496", "P48150", "WBGene00004483", "O45499", "WBGene00004495", "Q9N3X2", "WBGene00004473", "Q9XVP0", "WBGene00004484", "Q95Y04", "WBGene00004497", "Q22054", "WBGene00004485", "P90983", "WBGene00004498", "O01692", "WBGene00004486", "P48152", "WBGene00004472", "O18240", "WBGene00004487", "O18650", "WBGene00004488", "P48154", "WBGene00004470", "O17218", "WBGene00004491", "P49041", "WBGene00004474", "P51403", "WBGene00004471", "Q9NEN6", "WBGene00004475", "Q8WQA8", "WBGene00004489", "Q23312", "WBGene00004476", "O01869", "WBGene00004479", "P49197", "WBGene00004490", "P48156", "WBGene00004477", "Q20206", "WBGene00004480", "Q19877", "WBGene00004492", "Q20228", "WBGene00004478", "P49196", "WBGene00004481", "Q1XFY9", "WBGene00004493", "P46769", "WBGene00004469", "P51404", "WBGene00004482", "P52821", "WBGene00004494", "Q9TXP0", "WBGene00004496", "P48150", "WBGene00004483", "O45499", "WBGene00004495", "Q9N3X2", "WBGene00004473", "Q9XVP0", "WBGene00004484", "Q95Y04", "WBGene00004497", "Q22054", "WBGene00004485", "P90983", "WBGene00004498", "O01692", "WBGene00004486", "P48152", "WBGene00004472", "O18240", "WBGene00004487", "O18650", "WBGene00004488", "P48154", "WBGene00004470", "O17218", "WBGene00004491", "P49041", "WBGene00004474", "Q95QW0", "WBGene00015920", "O01974", "WBGene00001231", "Q94261", "WBGene00019543", "P34339", "WBGene00001209", "Q9XWP7", "WBGene00012738", "P30642", "WBGene00001227", "Q965S8", "WBGene00001232", "O02328", "WBGene00001226", "Q19706", "WBGene00001230", "O61820", "WBGene00001228", "Q18967", "WBGene00001229", "Q9XUP3", "WBGene00001233", "Q9XWI6", "WBGene00001225", "Q9TXU7", "WBGene00019162" ] }, "reaction_10537497": { "compartment": "compartment_70101", "id": "reaction_10537497", "reactome": "R-CEL-1799332", "name": "Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10537493", "species_10537491" ], "products": [ "species_10537495" ], "modifiers": [], "additional_components": [ "P91914", "WBGene00004441", "Q19869", "WBGene00004440", "O01868", "WBGene00004436", "P48162", "WBGene00004438", "P52819", "WBGene00004434", "P48158", "WBGene00004435", "Q09533", "WBGene00004421", "P34334", "WBGene00004433", "O02639", "WBGene00004431", "Q95Y90", "WBGene00004420", "O44480", "WBGene00004432", "Q22716", "WBGene00004446", "Q9U332", "WBGene00004445", "Q9XWS4", "WBGene00004444", "P52814", "WBGene00004453", "O45226", "WBGene00004443", "Q21930", "WBGene00004442", "P48166", "WBGene00004454", "Q9BKU5", "WBGene00021350", "P50880", "WBGene00004414", "P61866", "WBGene00004424", "O17570", "WBGene00004452", "Q19162", "WBGene00004423", "Q9U2A8", "WBGene00004456", "Q9N4I4", "WBGene00004412", "O62388", "WBGene00012179", "O01504", "WBGene00016493", "P49181", "WBGene00004450", "P91913", "WBGene00004409", "P49180", "WBGene00004447", "Q93572", "WBGene00004408", "P34662", "WBGene00004449", "Q9XVF7", "WBGene00004413", "O45946", "WBGene00004430", "Q966C6", "WBGene00004419", "Q9BL19", "WBGene00004429", "O01802", "WBGene00004418", "P91374", "WBGene00004427", "P47991", "WBGene00004417", "Q9XVE9", "WBGene00004426", "P49405", "WBGene00004416", "Q27389", "WBGene00004428", "P37165", "WBGene00006725", "P91128", "WBGene00004425", "O02056", "WBGene00004415", "P51403", "WBGene00004471", "Q9NEN6", "WBGene00004475", "Q8WQA8", "WBGene00004489", "Q23312", "WBGene00004476", "O01869", "WBGene00004479", "P49197", "WBGene00004490", "P48156", "WBGene00004477", "Q20206", "WBGene00004480", "Q19877", "WBGene00004492", "Q20228", "WBGene00004478", "P49196", "WBGene00004481", "Q1XFY9", "WBGene00004493", "P46769", "WBGene00004469", "P51404", "WBGene00004482", "P52821", "WBGene00004494", "Q9TXP0", "WBGene00004496", "P48150", "WBGene00004483", "O45499", "WBGene00004495", "Q9N3X2", "WBGene00004473", "Q9XVP0", "WBGene00004484", "Q95Y04", "WBGene00004497", "Q22054", "WBGene00004485", "P90983", "WBGene00004498", "O01692", "WBGene00004486", "P48152", "WBGene00004472", "O18240", "WBGene00004487", "O18650", "WBGene00004488", "P48154", "WBGene00004470", "O17218", "WBGene00004491", "P49041", "WBGene00004474", "G5EE80", "WBGene00009012", "P91240", "WBGene00017245", "O16927", "WBGene00017799", "P34642", "WBGene00013984", "O61749", "WBGene00018159", "Q20822", "WBGene00010097", "G5EE80", "WBGene00009012", "P91240", "WBGene00017245", "O16927", "WBGene00017799", "P34642", "WBGene00013984", "O61749", "WBGene00018159", "Q20822", "WBGene00010097", "P91914", "WBGene00004441", "Q19869", "WBGene00004440", "O01868", "WBGene00004436", "P48162", "WBGene00004438", "P52819", "WBGene00004434", "P48158", "WBGene00004435", "Q09533", "WBGene00004421", "P34334", "WBGene00004433", "O02639", "WBGene00004431", "Q95Y90", "WBGene00004420", "O44480", "WBGene00004432", "Q22716", "WBGene00004446", "Q9U332", "WBGene00004445", "Q9XWS4", "WBGene00004444", "P52814", "WBGene00004453", "O45226", "WBGene00004443", "Q21930", "WBGene00004442", "P48166", "WBGene00004454", "Q9BKU5", "WBGene00021350", "P50880", "WBGene00004414", "P61866", "WBGene00004424", "O17570", "WBGene00004452", "Q19162", "WBGene00004423", "Q9U2A8", "WBGene00004456", "Q9N4I4", "WBGene00004412", "O62388", "WBGene00012179", "O01504", "WBGene00016493", "P49181", "WBGene00004450", "P91913", "WBGene00004409", "P49180", "WBGene00004447", "Q93572", "WBGene00004408", "P34662", "WBGene00004449", "Q9XVF7", "WBGene00004413", "O45946", "WBGene00004430", "Q966C6", "WBGene00004419", "Q9BL19", "WBGene00004429", "O01802", "WBGene00004418", "P91374", "WBGene00004427", "P47991", "WBGene00004417", "Q9XVE9", "WBGene00004426", "P49405", "WBGene00004416", "Q27389", "WBGene00004428", "P37165", "WBGene00006725", "P91128", "WBGene00004425", "O02056", "WBGene00004415", "P51403", "WBGene00004471", "Q9NEN6", "WBGene00004475", "Q8WQA8", "WBGene00004489", "Q23312", "WBGene00004476", "O01869", "WBGene00004479", "P49197", "WBGene00004490", "P48156", "WBGene00004477", "Q20206", "WBGene00004480", "Q19877", "WBGene00004492", "Q20228", "WBGene00004478", "P49196", "WBGene00004481", "Q1XFY9", "WBGene00004493", "P46769", "WBGene00004469", "P51404", "WBGene00004482", "P52821", "WBGene00004494", "Q9TXP0", "WBGene00004496", "P48150", "WBGene00004483", "O45499", "WBGene00004495", "Q9N3X2", "WBGene00004473", "Q9XVP0", "WBGene00004484", "Q95Y04", "WBGene00004497", "Q22054", "WBGene00004485", "P90983", "WBGene00004498", "O01692", "WBGene00004486", "P48152", "WBGene00004472", "O18240", "WBGene00004487", "O18650", "WBGene00004488", "P48154", "WBGene00004470", "O17218", "WBGene00004491", "P49041", "WBGene00004474" ] }, "reaction_10556841": { "compartment": "compartment_70101", "id": "reaction_10556841", "reactome": "R-CEL-5691512", "name": "APEH hydrolyses NAc-Ser-protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5691496", "species_29356" ], "products": [ "species_6785226", "species_5691517" ], "modifiers": [ [ "species_10556838", "catalyst" ] ], "additional_components": [ "species_5691517", "species_6785219", "WBGene00001058" ] }, "reaction_10562140": { "compartment": "compartment_70101", "id": "reaction_10562140", "reactome": "R-CEL-6800138", "name": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to ETF1 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10562118", "species_71284" ], "products": [ "species_10562125", "species_71285" ], "modifiers": [ [ "species_10562137", "catalyst" ] ], "additional_components": [ "O45622", "WBGene00010405", "species_29438", "O16520", "WBGene00020269", "O45622", "WBGene00010405", "species_29438", "O16520", "WBGene00020269", "O16582", "WBGene00016341", "O45241", "WBGene00007312" ] }, "reaction_10535108": { "compartment": "compartment_12045", "id": "reaction_10535108", "reactome": "R-CEL-1483186", "name": "PC is converted to PS by PTDSS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426925", "species_200736" ], "products": [ "species_264618", "species_1500646" ], "modifiers": [ [ "species_10535105", "catalyst" ] ], "additional_components": [ "WBGene00013920" ] }, "reaction_10534897": { "compartment": "compartment_12045", "id": "reaction_10534897", "reactome": "R-CEL-1482816", "name": "PC is hydrolyzed to 1-acyl LPC by PLA2[6]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_426925" ], "products": [ "species_1524028", "species_1524021" ], "modifiers": [ [ "species_10534894", "catalyst" ] ], "additional_components": [ "Q3V5J7", "WBGene00044468", "O16654", "WBGene00044468", "Q17790", "WBGene00044468", "species_74016", "Q8MXR3", "WBGene00022233" ] }, "reaction_10534753": { "compartment": "compartment_12045", "id": "reaction_10534753", "reactome": "R-CEL-1482547", "name": "1-acyl LPC is acylated to PC by LPCAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524028", "species_1500578" ], "products": [ "species_426925", "species_76194" ], "modifiers": [ [ "species_10534731", "catalyst" ] ], "additional_components": [ "O01925", "WBGene00020115", "G5EC53", "WBGene00016934" ] }, "reaction_10567209": { "compartment": "compartment_12045", "id": "reaction_10567209", "reactome": "R-CEL-8874435", "name": "THEM86B hydrolyses PMCHO, PMETAM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_8874447" ], "products": [ "species_8874450", "species_5696116" ], "modifiers": [ [ "species_10567206", "catalyst" ] ], "additional_components": [ "CHEBI:17810", "CHEBI:17476", "CHEBI:36313", "CHEBI:36314", "WBGene00010943" ] }, "reaction_10534907": { "compartment": "compartment_12045", "id": "reaction_10534907", "reactome": "R-CEL-1482856", "name": "PC is hydrolyzed to 1-acyl LPC by PLA2[5]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_426925" ], "products": [ "species_1524028", "species_1524021" ], "modifiers": [ [ "species_10534904", "catalyst" ] ], "additional_components": [ "WBGene00016661" ] }, "reaction_10535867": { "compartment": "compartment_984", "id": "reaction_10535867", "reactome": "R-CEL-1602399", "name": "PC is hydrolyzed to 1-acyl LPC by PLB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_429802" ], "products": [ "species_1602390", "species_1602366" ], "modifiers": [ [ "species_10530529", "catalyst" ] ], "additional_components": [ "Q8MXQ8", "WBGene00022256", "Q9N2Z4", "WBGene00022256" ] }, "reaction_10535869": { "compartment": "compartment_984", "id": "reaction_10535869", "reactome": "R-CEL-1602417", "name": "PC is hydrolyzed to 1-acyl LPC by PLA2[16]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_429802" ], "products": [ "species_1602390", "species_1602366" ], "modifiers": [ [ "species_10535837", "catalyst" ], [ "species_10535855", "inhibitor" ] ], "additional_components": [ "species_74016", "Q17790", "WBGene00044468", "O16654", "WBGene00044468", "Q3V5J7", "WBGene00044468", "Q18339", "WBGene00016288", "G4RY15", "WBGene00015631", "P34472", "WBGene00010228", "Q22591", "WBGene00020585" ] }, "reaction_10534734": { "compartment": "compartment_12045", "id": "reaction_10534734", "reactome": "R-CEL-1482533", "name": "2-acyl LPC is acylated to PC by LPCAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500578", "species_975614" ], "products": [ "species_426925", "species_76194" ], "modifiers": [ [ "species_10534731", "catalyst" ] ], "additional_components": [ "O01925", "WBGene00020115", "G5EC53", "WBGene00016934" ] }, "reaction_10534914": { "compartment": "compartment_12045", "id": "reaction_10534914", "reactome": "R-CEL-1482868", "name": "PI is hydrolyzed to 1-acyl LPI by PLA2[12]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_426639" ], "products": [ "species_1498733", "species_1524021" ], "modifiers": [ [ "species_10534852", "catalyst" ] ], "additional_components": [ "Q3V5J7", "WBGene00044468", "O16654", "WBGene00044468", "Q17790", "WBGene00044468", "species_74016" ] }, "reaction_10534789": { "compartment": "compartment_12045", "id": "reaction_10534789", "reactome": "R-CEL-1482626", "name": "2-acyl LPI is acylated to PI by MBOAT7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1498737", "species_1500578" ], "products": [ "species_426639", "species_76194" ], "modifiers": [ [ "species_10534763", "catalyst" ] ], "additional_components": [ "WBGene00008806" ] }, "reaction_10535862": { "compartment": "compartment_984", "id": "reaction_10535862", "reactome": "R-CEL-1602377", "name": "PI is hydrolyzed to 1-acyl LPI by PLA2[15]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_426658" ], "products": [ "species_1602420", "species_1602366" ], "modifiers": [ [ "species_10535837", "catalyst" ], [ "species_10535855", "inhibitor" ] ], "additional_components": [ "species_74016", "Q17790", "WBGene00044468", "O16654", "WBGene00044468", "Q3V5J7", "WBGene00044468", "Q18339", "WBGene00016288", "G4RY15", "WBGene00015631", "P34472", "WBGene00010228", "Q22591", "WBGene00020585" ] }, "reaction_10534766": { "compartment": "compartment_12045", "id": "reaction_10534766", "reactome": "R-CEL-1482598", "name": "1-acyl LPI is acylated to PI by MBOAT7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1498733", "species_1500578" ], "products": [ "species_426639", "species_76194" ], "modifiers": [ [ "species_10534763", "catalyst" ] ], "additional_components": [ "WBGene00008806" ] }, "reaction_10557548": { "compartment": "compartment_17906", "id": "reaction_10557548", "reactome": "R-CEL-5696074", "name": "AGK:Mg2+ phosphorylates MAG, DAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5696066", "species_5696069" ], "products": [ "species_5696026", "species_5696037" ], "modifiers": [ [ "species_10557545", "catalyst" ] ], "additional_components": [ "species_6814795", "species_114519", "species_1524101", "species_417891", "Q10123", "WBGene00018674", "species_114632" ] }, "reaction_10534916": { "compartment": "compartment_12045", "id": "reaction_10534916", "reactome": "R-CEL-1482884", "name": "PE is hydrolyzed to 1-acyl LPE by PLA2[2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1500581" ], "products": [ "species_1498738", "species_1524021" ], "modifiers": [ [ "species_10534904", "catalyst" ] ], "additional_components": [ "WBGene00016661" ] }, "reaction_10534918": { "compartment": "compartment_12045", "id": "reaction_10534918", "reactome": "R-CEL-1482887", "name": "PE is hydrolyzed to 1-acyl LPE by PLA2[3]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1500581" ], "products": [ "species_1498738", "species_1524021" ], "modifiers": [ [ "species_10534894", "catalyst" ] ], "additional_components": [ "Q3V5J7", "WBGene00044468", "O16654", "WBGene00044468", "Q17790", "WBGene00044468", "species_74016", "Q8MXR3", "WBGene00022233" ] }, "reaction_10535864": { "compartment": "compartment_984", "id": "reaction_10535864", "reactome": "R-CEL-1602398", "name": "PE is hydrolyzed to 1-acyl LPE by PLA2[16]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1602375", "species_109276" ], "products": [ "species_1602372", "species_1602366" ], "modifiers": [ [ "species_10535837", "catalyst" ], [ "species_10535855", "inhibitor" ] ], "additional_components": [ "species_74016", "Q17790", "WBGene00044468", "O16654", "WBGene00044468", "Q3V5J7", "WBGene00044468", "Q18339", "WBGene00016288", "G4RY15", "WBGene00015631", "P34472", "WBGene00010228", "Q22591", "WBGene00020585" ] }, "reaction_10557512": { "compartment": "compartment_70101", "id": "reaction_10557512", "reactome": "R-CEL-5694583", "name": "ABHD4 hydrolyses NAPE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5694568", "species_29356" ], "products": [ "species_5694580", "species_5694567" ], "modifiers": [ [ "species_10557509", "catalyst" ] ], "additional_components": [ "WBGene00007711" ] }, "reaction_10534842": { "compartment": "compartment_12045", "id": "reaction_10534842", "reactome": "R-CEL-1482667", "name": "1-acyl LPE is acylated to PE by LPEAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500578", "species_1498738" ], "products": [ "species_76194", "species_1500581" ], "modifiers": [ [ "species_10534808", "catalyst" ] ], "additional_components": [ "G5EC53", "WBGene00016934", "H9G2W5", "WBGene00007446", "O01925", "WBGene00020115" ] }, "reaction_10534811": { "compartment": "compartment_12045", "id": "reaction_10534811", "reactome": "R-CEL-1482646", "name": "2-acyl LPE is acylated to PE by LPEAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1498729", "species_1500578" ], "products": [ "species_76194", "species_1500581" ], "modifiers": [ [ "species_10534808", "catalyst" ] ], "additional_components": [ "G5EC53", "WBGene00016934", "H9G2W5", "WBGene00007446", "O01925", "WBGene00020115" ] }, "reaction_10534786": { "compartment": "compartment_17906", "id": "reaction_10534786", "reactome": "R-CEL-1482604", "name": "PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1500590" ], "products": [ "species_1500580", "species_1524103" ], "modifiers": [ [ "species_10534783", "catalyst" ] ], "additional_components": [ "O16654", "WBGene00044468", "Q17790", "WBGene00044468", "Q3V5J7", "WBGene00044468" ] }, "reaction_10534981": { "compartment": "compartment_70101", "id": "reaction_10534981", "reactome": "R-CEL-1483002", "name": "DHAP is converted to 1-acyl GO3P by GNPAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500578", "species_75970" ], "products": [ "species_75973", "species_76194" ], "modifiers": [ [ "species_10534978", "catalyst" ] ], "additional_components": [ "WBGene00012911" ] }, "reaction_10512710": { "compartment": "compartment_5460", "id": "reaction_10512710", "reactome": "R-CEL-188467", "name": "Gly-3-P+FAD->DHAP+FADH2 (catalyzed by mitochondrial Gly-Phos dehydrogenase)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113596", "species_188458" ], "products": [ "species_31649", "species_188451" ], "modifiers": [ [ "species_10512707", "catalyst" ] ], "additional_components": [ "WBGene00012031" ] }, "reaction_10534758": { "compartment": "compartment_17906", "id": "reaction_10534758", "reactome": "R-CEL-1482548", "name": "1-acyl LPA is acylated to PA by AGPAT5 (OM)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500578", "species_1500580" ], "products": [ "species_1500590", "species_76194" ], "modifiers": [ [ "species_10534755", "catalyst" ] ], "additional_components": [ "WBGene00017888" ] }, "reaction_10534839": { "compartment": "compartment_70101", "id": "reaction_10534839", "reactome": "R-CEL-1482656", "name": "PA is hydrolysed to 1-acyl LPA by PLA2[1]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_426755" ], "products": [ "species_1500604", "species_1524021" ], "modifiers": [ [ "species_10534783", "catalyst" ] ], "additional_components": [ "O16654", "WBGene00044468", "Q17790", "WBGene00044468", "Q3V5J7", "WBGene00044468" ] }, "reaction_10534855": { "compartment": "compartment_12045", "id": "reaction_10534855", "reactome": "R-CEL-1482679", "name": "PA is hydrolysed to 1-acyl LPA by PLA2G2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_426755" ], "products": [ "species_1500604", "species_1524021" ], "modifiers": [ [ "species_10534852", "catalyst" ] ], "additional_components": [ "Q3V5J7", "WBGene00044468", "O16654", "WBGene00044468", "Q17790", "WBGene00044468", "species_74016" ] }, "reaction_10507577": { "compartment": "compartment_70101", "id": "reaction_10507577", "reactome": "R-CEL-75889", "name": "DHAP is converted to G3P by GPD1/GPD1L", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_75970", "species_73473" ], "products": [ "species_76114", "species_29360" ], "modifiers": [ [ "species_10507574", "catalyst" ] ], "additional_components": [ "Q9XTS4", "WBGene00009824", "P34517", "WBGene00010778" ] }, "reaction_10527340": { "compartment": "compartment_12045", "id": "reaction_10527340", "reactome": "R-CEL-549112", "name": "G3P is acylated to 1-acyl LPA by AGPAT6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500578", "species_76114" ], "products": [ "species_1500604", "species_76194" ], "modifiers": [ [ "species_10507520", "catalyst" ] ], "additional_components": [ "G5EE59", "WBGene00010902", "Q21812", "WBGene00011106", "Q9N5S8", "WBGene00018657" ] }, "reaction_10507532": { "compartment": "compartment_12045", "id": "reaction_10507532", "reactome": "R-CEL-75885", "name": "1-acyl LPA is acylated to PA by AGPAT (LPAAT)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500604", "species_1500578" ], "products": [ "species_426755", "species_76194" ], "modifiers": [ [ "species_10507529", "catalyst" ] ], "additional_components": [ "G5EE59", "WBGene00010902", "Q21812", "WBGene00011106", "Q9N5S8", "WBGene00018657", "O16526", "WBGene00020264", "Q22267", "WBGene00011543", "Q93841", "WBGene00010339", "Q95R12", "WBGene00017888" ] }, "reaction_10535100": { "compartment": "compartment_12045", "id": "reaction_10535100", "reactome": "R-CEL-1483182", "name": "PC is hydrolyzed to PA and choline by PLD1/2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_426925" ], "products": [ "species_264618", "species_426755" ], "modifiers": [ [ "species_10535095", "catalyst" ] ], "additional_components": [ "WBGene00004040" ] }, "reaction_10534863": { "compartment": "compartment_17906", "id": "reaction_10534863", "reactome": "R-CEL-1482695", "name": "G3P is acylated to 1-acyl LPA by GPAM/GPAT2 (OM)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500578", "species_76114" ], "products": [ "species_76194", "species_1500580" ], "modifiers": [ [ "species_10507537", "catalyst" ] ], "additional_components": [ "WBGene00017261" ] }, "reaction_10535871": { "compartment": "compartment_984", "id": "reaction_10535871", "reactome": "R-CEL-1602446", "name": "PA is hydrolyzed to 1-acyl LPA by PLA2[15]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_1602448" ], "products": [ "species_1602447", "species_1602366" ], "modifiers": [ [ "species_10535837", "catalyst" ], [ "species_10535855", "inhibitor" ] ], "additional_components": [ "species_74016", "Q17790", "WBGene00044468", "O16654", "WBGene00044468", "Q3V5J7", "WBGene00044468", "Q18339", "WBGene00016288", "G4RY15", "WBGene00015631", "P34472", "WBGene00010228", "Q22591", "WBGene00020585" ] }, "reaction_10569180": { "compartment": "compartment_984", "id": "reaction_10569180", "reactome": "R-CEL-8952251", "name": "PLA2G15 hydrolyses LPC to GPCho and LCFA(-)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_2173763" ], "products": [ "species_8954142", "species_8952253" ], "modifiers": [ [ "species_10569177", "catalyst" ] ], "additional_components": [ "WBGene00010872" ] }, "reaction_10534976": { "compartment": "compartment_12045", "id": "reaction_10534976", "reactome": "R-CEL-1482976", "name": "CDP-DAG is converted to PI by CDIPT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426955", "species_426910" ], "products": [ "species_426639", "species_109395" ], "modifiers": [ [ "species_10534973", "catalyst" ] ], "additional_components": [ "species_114632", "species_266099", "Q9U2G1", "WBGene00012897" ] }, "reaction_10535085": { "compartment": "compartment_12045", "id": "reaction_10535085", "reactome": "R-CEL-1483121", "name": "PA is converted to CDP-DAG by CDS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_110614", "species_426755" ], "products": [ "species_111294", "species_426955" ], "modifiers": [ [ "species_10535082", "catalyst" ] ], "additional_components": [ "species_114632", "P53439", "WBGene00016384" ] }, "reaction_10566702": { "compartment": "compartment_70101", "id": "reaction_10566702", "reactome": "R-CEL-8869241", "name": "PITPNM1,2,3 exchange PI for PA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426639", "species_1602448" ], "products": [ "species_426755", "species_426658" ], "modifiers": [ [ "species_10566697", "catalyst" ] ], "additional_components": [ "WBGene00010813" ] }, "reaction_10535034": { "compartment": "compartment_70616", "id": "reaction_10535034", "reactome": "R-CEL-1483063", "name": "PG and CDP-DAG are converted to CL by CRLS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524042", "species_1524064" ], "products": [ "species_1524072", "species_1524067" ], "modifiers": [ [ "species_10534747", "catalyst" ] ], "additional_components": [ "WBGene00017763" ] }, "reaction_10535057": { "compartment": "compartment_12045", "id": "reaction_10535057", "reactome": "R-CEL-1483081", "name": "PCho and CTP are condensed to CDP-Cho by PCYT1 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_110614", "species_1524071" ], "products": [ "species_111294", "species_1524060" ], "modifiers": [ [ "species_10535054", "catalyst" ] ], "additional_components": [ "Q8IU09", "WBGene00021215", "P49583", "WBGene00017241" ] }, "reaction_10534947": { "compartment": "compartment_12045", "id": "reaction_10534947", "reactome": "R-CEL-1482961", "name": "CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524060", "species_1500596" ], "products": [ "species_426925", "species_109395" ], "modifiers": [ [ "species_10534944", "catalyst" ] ], "additional_components": [ "species_114632", "species_266099", "G5EC09", "WBGene00009057", "G5EC25", "WBGene00013024" ] }, "reaction_10534966": { "compartment": "compartment_20699", "id": "reaction_10534966", "reactome": "R-CEL-1482973", "name": "CDP-Cho and DAG are converted to PC by CHPT1 at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524057", "species_1524060" ], "products": [ "species_429785", "species_109395" ], "modifiers": [ [ "species_10534963", "catalyst" ] ], "additional_components": [ "species_114632", "species_266099", "G5EC25", "WBGene00013024" ] }, "reaction_10535031": { "compartment": "compartment_70101", "id": "reaction_10535031", "reactome": "R-CEL-1483004", "name": "Cho is phosphorylated to PCho by CHK dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_264618", "species_113592" ], "products": [ "species_29370", "species_1524071" ], "modifiers": [ [ "species_10535028", "catalyst" ] ], "additional_components": [ "P46560", "WBGene00000513", "O17610", "WBGene00000509", "Q22820", "WBGene00000515", "P46558", "WBGene00000511", "Q22942", "WBGene00000510", "P46559", "WBGene00000512", "Q9GZF3", "WBGene00000514" ] }, "reaction_10557483": { "compartment": "compartment_876", "id": "reaction_10557483", "reactome": "R-CEL-5694485", "name": "ABHD3 hydrolyses LPC(14:0) to 1AGPC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_5694502" ], "products": [ "species_5694457", "species_1861754" ], "modifiers": [ [ "species_10557480", "catalyst" ] ], "additional_components": [ "Q18610", "WBGene00016644", "Q9U1Z6", "WBGene00013358" ] }, "reaction_10567146": { "compartment": "compartment_70101", "id": "reaction_10567146", "reactome": "R-CEL-8873929", "name": "Casein kinase II phosphorylates STARD10", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10567141" ], "products": [ "species_29370", "species_10567144" ], "modifiers": [ [ "species_10515097", "catalyst" ] ], "additional_components": [ "WBGene00012127", "WBGene00012127", "P18334", "WBGene00002191", "P28548", "WBGene00002196" ] }, "reaction_10518395": { "compartment": "compartment_984", "id": "reaction_10518395", "reactome": "R-CEL-372519", "name": "AcCho is hydrolyzed to Cho and acetate by ACHE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_372533" ], "products": [ "species_1524044", "species_264638" ], "modifiers": [ [ "species_10518390", "catalyst" ], [ "species_10518393", "inhibitor" ] ], "additional_components": [ "Q23268", "WBGene00013873", "Q04457", "WBGene00001578", "H9G2Y9", "WBGene00013874", "A0A1C3NSL8", "WBGene00017478", "Q4LDP0", "WBGene00020891", "Q21266", "WBGene00019477", "O01302", "WBGene00011362", "G5EDJ7", "WBGene00013875", "Q9XW75", "WBGene00013540", "Q22008", "WBGene00020125", "P92016", "WBGene00011364", "H2L0K7", "WBGene00020330", "Q23268", "WBGene00013873", "Q04457", "WBGene00001578", "H9G2Y9", "WBGene00013874", "A0A1C3NSL8", "WBGene00017478", "Q4LDP0", "WBGene00020891", "Q21266", "WBGene00019477", "O01302", "WBGene00011362", "G5EDJ7", "WBGene00013875", "Q9XW75", "WBGene00013540", "Q22008", "WBGene00020125", "P92016", "WBGene00011364", "H2L0K7", "WBGene00020330" ] }, "reaction_10567581": { "compartment": "compartment_12045", "id": "reaction_10567581", "reactome": "R-CEL-8877153", "name": "STARD7 binds PC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426925", "species_10567577" ], "products": [ "species_10567579" ], "modifiers": [], "additional_components": [ "WBGene00007386", "Q17764", "WBGene00007386", "species_194276" ] }, "reaction_10535075": { "compartment": "compartment_20699", "id": "reaction_10535075", "reactome": "R-CEL-1483087", "name": "PI is exchanged with PC by PITPNB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_429785", "species_10535071" ], "products": [ "species_1524146", "species_10535073" ], "modifiers": [], "additional_components": [ "species_426639", "Q95XP0", "WBGene00022155", "Q965T2", "WBGene00022155", "Q95XP0", "WBGene00022155", "Q965T2", "WBGene00022155", "species_194276" ] }, "reaction_10535139": { "compartment": "compartment_20699", "id": "reaction_10535139", "reactome": "R-CEL-1483211", "name": "PC:PITPNB is transported from the Golgi membrane to the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10535073" ], "products": [ "species_10535137" ], "modifiers": [], "additional_components": [ "Q95XP0", "WBGene00022155", "Q965T2", "WBGene00022155", "species_194276", "species_194276", "Q95XP0", "WBGene00022155", "Q965T2", "WBGene00022155" ] }, "reaction_10535148": { "compartment": "compartment_12045", "id": "reaction_10535148", "reactome": "R-CEL-1483229", "name": "PI:PITPNB is transported from the ER membrane to the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10535141" ], "products": [ "species_10535071" ], "modifiers": [], "additional_components": [ "species_426639", "Q95XP0", "WBGene00022155", "Q965T2", "WBGene00022155", "species_426639", "Q95XP0", "WBGene00022155", "Q965T2", "WBGene00022155" ] }, "reaction_10507366": { "compartment": "compartment_7660", "id": "reaction_10507366", "reactome": "R-CEL-75172", "name": "Formation of RAD50:MRE11 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10507357", "species_10507362" ], "products": [ "species_10507364" ], "modifiers": [], "additional_components": [ "WBGene00004296", "WBGene00003405", "Q23255", "WBGene00003405", "O44199", "WBGene00004296" ] }, "reaction_10571888": { "compartment": "compartment_70101", "id": "reaction_10571888", "reactome": "R-CEL-9603804", "name": "PEX19 binds class I peroxisomal membrane proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10571868", "species_10520426" ], "products": [ "species_10571870" ], "modifiers": [], "additional_components": [ "A0A486WWU7", "WBGene00000110", "O44555", "WBGene00000111", "Q93930", "WBGene00004199", "P54815", "WBGene00010557", "Q7YWV6", "WBGene00011826", "O45730", "WBGene00004061", "Q6AHP8", "WBGene00001425", "P91262", "WBGene00017574", "Q19189", "WBGene00004197", "Q18598", "WBGene00004059", "A0A1D3PCN1", "WBGene00270319", "Q9XTZ5", "WBGene00007680", "Q19951", "WBGene00004198", "WBGene00004201", "P34453", "WBGene00004201", "A0A486WWU7", "WBGene00000110", "O44555", "WBGene00000111", "Q93930", "WBGene00004199", "P54815", "WBGene00010557", "Q7YWV6", "WBGene00011826", "O45730", "WBGene00004061", "Q6AHP8", "WBGene00001425", "P91262", "WBGene00017574", "Q19189", "WBGene00004197", "Q18598", "WBGene00004059", "A0A1D3PCN1", "WBGene00270319", "Q9XTZ5", "WBGene00007680", "Q19951", "WBGene00004198" ] }, "reaction_10571884": { "compartment": "compartment_17947", "id": "reaction_10571884", "reactome": "R-CEL-9603775", "name": "PEX3:PEX19:class I PMP dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10571872" ], "products": [ "species_10571882", "species_10520426", "species_10520404" ], "modifiers": [], "additional_components": [ "Q18028", "WBGene00004193", "P34453", "WBGene00004201", "A0A486WWU7", "WBGene00000110", "O44555", "WBGene00000111", "Q93930", "WBGene00004199", "P54815", "WBGene00010557", "Q7YWV6", "WBGene00011826", "O45730", "WBGene00004061", "Q6AHP8", "WBGene00001425", "P91262", "WBGene00017574", "Q19189", "WBGene00004197", "Q18598", "WBGene00004059", "A0A1D3PCN1", "WBGene00270319", "Q9XTZ5", "WBGene00007680", "Q19951", "WBGene00004198", "A0A1D3PCN1", "WBGene00270319", "Q9XTZ5", "WBGene00007680", "Q19951", "WBGene00004198", "P54815", "WBGene00010557", "O44555", "WBGene00000111", "A0A486WWU7", "WBGene00000110", "Q93930", "WBGene00004199", "Q6AHP8", "WBGene00001425", "Q18598", "WBGene00004059", "Q19189", "WBGene00004197", "Q7YWV6", "WBGene00011826", "P91262", "WBGene00017574", "O45730", "WBGene00004061", "WBGene00004201", "WBGene00004193" ] }, "reaction_10571886": { "compartment": "compartment_17947", "id": "reaction_10571886", "reactome": "R-CEL-9603784", "name": "PEX19:class I PMP binds PEX3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10571870", "species_10520404" ], "products": [ "species_10571872" ], "modifiers": [], "additional_components": [ "P34453", "WBGene00004201", "A0A486WWU7", "WBGene00000110", "O44555", "WBGene00000111", "Q93930", "WBGene00004199", "P54815", "WBGene00010557", "Q7YWV6", "WBGene00011826", "O45730", "WBGene00004061", "Q6AHP8", "WBGene00001425", "P91262", "WBGene00017574", "Q19189", "WBGene00004197", "Q18598", "WBGene00004059", "A0A1D3PCN1", "WBGene00270319", "Q9XTZ5", "WBGene00007680", "Q19951", "WBGene00004198", "WBGene00004193", "Q18028", "WBGene00004193", "P34453", "WBGene00004201", "A0A486WWU7", "WBGene00000110", "O44555", "WBGene00000111", "Q93930", "WBGene00004199", "P54815", "WBGene00010557", "Q7YWV6", "WBGene00011826", "O45730", "WBGene00004061", "Q6AHP8", "WBGene00001425", "P91262", "WBGene00017574", "Q19189", "WBGene00004197", "Q18598", "WBGene00004059", "A0A1D3PCN1", "WBGene00270319", "Q9XTZ5", "WBGene00007680", "Q19951", "WBGene00004198" ] }, "reaction_10551384": { "compartment": "compartment_70101", "id": "reaction_10551384", "reactome": "R-CEL-5334794", "name": "FABPs bind LCFAs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8876730", "species_10551380" ], "products": [ "species_10551382" ], "modifiers": [], "additional_components": [ "O02324", "WBGene00002260", "O01812", "WBGene00002258", "O01814", "WBGene00002257", "O02323", "WBGene00002259", "Q965W1", "WBGene00021486", "O02324", "WBGene00002260", "O01812", "WBGene00002258", "O01814", "WBGene00002257", "O02323", "WBGene00002259", "Q965W1", "WBGene00021486", "species_8876730" ] }, "reaction_10564685": { "compartment": "compartment_70101", "id": "reaction_10564685", "reactome": "R-CEL-8848339", "name": "PNPLA5 hydrolyzes TAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_549167" ], "products": [ "species_8876730", "species_76103" ], "modifiers": [ [ "species_10564682", "catalyst" ] ], "additional_components": [ "Q11186", "WBGene00015484", "Q18948", "WBGene00015241", "Q9N5Z7", "WBGene00015241" ] }, "reaction_10571751": { "compartment": "compartment_17947", "id": "reaction_10571751", "reactome": "R-CEL-9033485", "name": "PEX2:PEX10:PEX12 monoubiquitinates PEX5L at cysteine-11", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10571746" ], "products": [ "species_10532186", "species_10571748" ], "modifiers": [ [ "species_10571746", "catalyst" ] ], "additional_components": [ "Q19951", "WBGene00004198", "Q93930", "WBGene00004199", "Q18355", "WBGene00016318", "Q19189", "WBGene00004197", "Q18426", "WBGene00004194", "P35129", "WBGene00002344", "P91853", "WBGene00006732", "Q17720", "WBGene00006717", "Q20617", "WBGene00006719", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "P35129", "WBGene00002344", "P91853", "WBGene00006732", "Q17720", "WBGene00006717", "Q20617", "WBGene00006719", "Q19951", "WBGene00004198", "Q93930", "WBGene00004199", "Q18355", "WBGene00016318", "Q19189", "WBGene00004197", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "Q18426", "WBGene00004194", "Q19951", "WBGene00004198", "Q93930", "WBGene00004199", "Q18355", "WBGene00016318", "Q19189", "WBGene00004197", "Q18426", "WBGene00004194", "P35129", "WBGene00002344", "P91853", "WBGene00006732", "Q17720", "WBGene00006717", "Q20617", "WBGene00006719", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727" ] }, "reaction_10571738": { "compartment": "compartment_17947", "id": "reaction_10571738", "reactome": "R-CEL-9033235", "name": "Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10571710" ], "products": [ "species_10569900", "species_10571736" ], "modifiers": [], "additional_components": [ "Q18122", "WBGene00016034", "O16249", "WBGene00018426", "Q17499", "WBGene00007175", "A0A486WVT5", "WBGene00011850", "Q9BIA9", "WBGene00015887", "Q9XW87", "WBGene00013541", "P91148", "WBGene00003584", "G5EGA6", "WBGene00010063", "B3WFZ3", "WBGene00020989", "O01862", "WBGene00020989", "O45003", "WBGene00020989", "Q9GYN3", "WBGene00020989", "Q8MYL7", "WBGene00013220", "O01739", "WBGene00017648", "O45307", "WBGene00008127", "Q19564", "WBGene00017565", "Q95XG9", "WBGene00022076", "B1GRK5", "WBGene00018286", "O62138", "WBGene00008566", "Q18916", "WBGene00017012", "Q19878", "WBGene00009218", "G5EFP8", "WBGene00012911", "H9G2T4", "WBGene00010317", "Q94055", "WBGene00011767", "Q18006", "WBGene00015783", "Q18973", "WBGene00017054", "O76383", "WBGene00016061", "Q93839", "WBGene00010336", "O62137", "WBGene00008565", "O62139", "WBGene00008567", "O62140", "WBGene00008564", "P34355", "WBGene00008167", "Q20048", "WBGene00009439", "Q20992", "WBGene00019060", "Q95XN1", "WBGene00022150", "O17761", "WBGene00001157", "Q19058", "WBGene00017123", "Q20959", "WBGene00019022", "Q9NA25", "WBGene00003585", "Q17474", "WBGene00007143", "Q18426", "WBGene00004194", "Q19951", "WBGene00004198", "Q93930", "WBGene00004199", "Q18355", "WBGene00016318", "Q19189", "WBGene00004197", "Q19951", "WBGene00004198", "Q93930", "WBGene00004199", "Q18355", "WBGene00016318", "Q19189", "WBGene00004197", "Q18426", "WBGene00004194", "O76383", "WBGene00016061", "Q20992", "WBGene00019060", "B3WFZ3", "WBGene00020989", "O01862", "WBGene00020989", "O45003", "WBGene00020989", "Q9GYN3", "WBGene00020989", "Q9BIA9", "WBGene00015887", "Q17474", "WBGene00007143", "Q95XG9", "WBGene00022076", "Q19058", "WBGene00017123", "O17761", "WBGene00001157", "Q20048", "WBGene00009439", "O62138", "WBGene00008566", "Q18006", "WBGene00015783", "B1GRK5", "WBGene00018286", "Q18916", "WBGene00017012", "Q19878", "WBGene00009218", "Q20959", "WBGene00019022", "G5EFP8", "WBGene00012911", "A0A486WVT5", "WBGene00011850", "Q19564", "WBGene00017565", "O01739", "WBGene00017648", "O45307", "WBGene00008127", "Q18973", "WBGene00017054", "Q17499", "WBGene00007175", "Q95XN1", "WBGene00022150", "Q94055", "WBGene00011767", "Q9NA25", "WBGene00003585", "H9G2T4", "WBGene00010317", "O16249", "WBGene00018426", "Q9XW87", "WBGene00013541", "G5EGA6", "WBGene00010063", "P34355", "WBGene00008167", "Q93839", "WBGene00010336", "O62139", "WBGene00008567", "O62140", "WBGene00008564", "O62137", "WBGene00008565", "Q18122", "WBGene00016034", "P91148", "WBGene00003584", "Q8MYL7", "WBGene00013220" ] }, "reaction_10571740": { "compartment": "compartment_17947", "id": "reaction_10571740", "reactome": "R-CEL-9033236", "name": "PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10571708", "species_10571706" ], "products": [ "species_10571710" ], "modifiers": [], "additional_components": [ "Q19951", "WBGene00004198", "Q93930", "WBGene00004199", "Q18355", "WBGene00016318", "Q19189", "WBGene00004197", "Q18122", "WBGene00016034", "O16249", "WBGene00018426", "Q17499", "WBGene00007175", "A0A486WVT5", "WBGene00011850", "Q9BIA9", "WBGene00015887", "Q9XW87", "WBGene00013541", "P91148", "WBGene00003584", "G5EGA6", "WBGene00010063", "B3WFZ3", "WBGene00020989", "O01862", "WBGene00020989", "O45003", "WBGene00020989", "Q9GYN3", "WBGene00020989", "Q8MYL7", "WBGene00013220", "O01739", "WBGene00017648", "O45307", "WBGene00008127", "Q19564", "WBGene00017565", "Q95XG9", "WBGene00022076", "B1GRK5", "WBGene00018286", "O62138", "WBGene00008566", "Q18916", "WBGene00017012", "Q19878", "WBGene00009218", "G5EFP8", "WBGene00012911", "H9G2T4", "WBGene00010317", "Q94055", "WBGene00011767", "Q18006", "WBGene00015783", "Q18973", "WBGene00017054", "O76383", "WBGene00016061", "Q93839", "WBGene00010336", "O62137", "WBGene00008565", "O62139", "WBGene00008567", "O62140", "WBGene00008564", "P34355", "WBGene00008167", "Q20048", "WBGene00009439", "Q20992", "WBGene00019060", "Q95XN1", "WBGene00022150", "O17761", "WBGene00001157", "Q19058", "WBGene00017123", "Q20959", "WBGene00019022", "Q9NA25", "WBGene00003585", "Q17474", "WBGene00007143", "Q18426", "WBGene00004194", "Q18122", "WBGene00016034", "O16249", "WBGene00018426", "Q17499", "WBGene00007175", "A0A486WVT5", "WBGene00011850", "Q9BIA9", "WBGene00015887", "Q9XW87", "WBGene00013541", "P91148", "WBGene00003584", "G5EGA6", "WBGene00010063", "B3WFZ3", "WBGene00020989", "O01862", "WBGene00020989", "O45003", "WBGene00020989", "Q9GYN3", "WBGene00020989", "Q8MYL7", "WBGene00013220", "O01739", "WBGene00017648", "O45307", "WBGene00008127", "Q19564", "WBGene00017565", "Q95XG9", "WBGene00022076", "B1GRK5", "WBGene00018286", "O62138", "WBGene00008566", "Q18916", "WBGene00017012", "Q19878", "WBGene00009218", "G5EFP8", "WBGene00012911", "H9G2T4", "WBGene00010317", "Q94055", "WBGene00011767", "Q18006", "WBGene00015783", "Q18973", "WBGene00017054", "O76383", "WBGene00016061", "Q93839", "WBGene00010336", "O62137", "WBGene00008565", "O62139", "WBGene00008567", "O62140", "WBGene00008564", "P34355", "WBGene00008167", "Q20048", "WBGene00009439", "Q20992", "WBGene00019060", "Q95XN1", "WBGene00022150", "O17761", "WBGene00001157", "Q19058", "WBGene00017123", "Q20959", "WBGene00019022", "Q9NA25", "WBGene00003585", "Q17474", "WBGene00007143", "Q18426", "WBGene00004194", "Q19951", "WBGene00004198", "Q93930", "WBGene00004199", "Q18355", "WBGene00016318", "Q19189", "WBGene00004197" ] }, "reaction_10572195": { "compartment": "compartment_70101", "id": "reaction_10572195", "reactome": "R-CEL-9617595", "name": "SGTA binds mislocalized membrane protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10572191", "species_10571993" ], "products": [ "species_10572193" ], "modifiers": [], "additional_components": [ "Q19767", "WBGene00004898", "Q94057", "WBGene00044062", "Q95XH1", "WBGene00022077", "G5EBK2", "WBGene00014084", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q10651", "WBGene00000149", "Q21746", "WBGene00019893", "Q21746", "WBGene00019893", "Q19767", "WBGene00004898", "Q94057", "WBGene00044062", "Q95XH1", "WBGene00022077", "G5EBK2", "WBGene00014084", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q10651", "WBGene00000149" ] }, "reaction_10572045": { "compartment": "compartment_70101", "id": "reaction_10572045", "reactome": "R-CEL-9609921", "name": "SGTA binds Tail-anchored protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10572041", "species_10571993" ], "products": [ "species_10572043" ], "modifiers": [], "additional_components": [ "A0A486WWU7", "WBGene00000110", "O44555", "WBGene00000111", "Q93838", "WBGene00010337", "Q8MXH3", "WBGene00020374", "Q95XS2", "WBGene00021427", "O16000", "WBGene00006798", "Q19767", "WBGene00004898", "Q94057", "WBGene00044062", "Q95XH1", "WBGene00022077", "G5EBK2", "WBGene00014084", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q19967", "WBGene00001303", "Q20797", "WBGene00006373", "O01816", "WBGene00020931", "Q93315", "WBGene00007848", "A0A2K5ATR7", "WBGene00022450", "Q21746", "WBGene00019893", "Q21746", "WBGene00019893", "A0A486WWU7", "WBGene00000110", "O44555", "WBGene00000111", "Q93838", "WBGene00010337", "Q8MXH3", "WBGene00020374", "Q95XS2", "WBGene00021427", "O16000", "WBGene00006798", "Q19767", "WBGene00004898", "Q94057", "WBGene00044062", "Q95XH1", "WBGene00022077", "G5EBK2", "WBGene00014084", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q19967", "WBGene00001303", "Q20797", "WBGene00006373", "O01816", "WBGene00020931", "Q93315", "WBGene00007848", "A0A2K5ATR7", "WBGene00022450" ] }, "reaction_10528387": { "compartment": "compartment_876", "id": "reaction_10528387", "reactome": "R-CEL-888589", "name": "Release of GABA at the synapse", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74016", "species_10528368" ], "products": [ "species_10516825", "species_10516809", "species_10516744", "species_10516631", "species_10516823", "species_10528374", "species_352003", "species_10528372", "species_10516754", "species_10528370", "species_10528384" ], "modifiers": [ [ "species_10528368", "catalyst" ] ], "additional_components": [ "Q22366", "WBGene00006750", "G5EEN8", "WBGene00006454", "A5PEW5", "WBGene00004364", "P34815", "WBGene00006757", "Q9GUM7", "WBGene00022271", "O16000", "WBGene00006798", "G5EDB7", "WBGene00006762", "E5QCE7", "WBGene00001032", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q19767", "WBGene00004898", "Q94057", "WBGene00044062", "Q95XH1", "WBGene00022077", "G5EBK2", "WBGene00014084", "P09446", "WBGene00002005", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "Q94986", "WBGene00004267", "species_352003", "P34579", "WBGene00006783", "WBGene00004267", "species_74016", "G5EEN8", "WBGene00006454", "A5PEW5", "WBGene00004364", "Q94057", "WBGene00044062", "Q95XH1", "WBGene00022077", "G5EBK2", "WBGene00014084", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q19767", "WBGene00004898", "O16000", "WBGene00006798", "WBGene00022271", "WBGene00006757", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "WBGene00002005", "WBGene00001032", "WBGene00006750", "WBGene00006783", "G5EDB7", "WBGene00006762", "Q22366", "WBGene00006750", "G5EEN8", "WBGene00006454", "A5PEW5", "WBGene00004364", "P34815", "WBGene00006757", "Q9GUM7", "WBGene00022271", "O16000", "WBGene00006798", "G5EDB7", "WBGene00006762", "E5QCE7", "WBGene00001032", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q19767", "WBGene00004898", "Q94057", "WBGene00044062", "Q95XH1", "WBGene00022077", "G5EBK2", "WBGene00014084", "P09446", "WBGene00002005", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "Q94986", "WBGene00004267", "species_352003", "P34579", "WBGene00006783" ] }, "reaction_10528390": { "compartment": "compartment_70101", "id": "reaction_10528390", "reactome": "R-CEL-888592", "name": "Loading of GABA into clathrin sculpted GABA transport vesicle lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352011" ], "products": [ "species_428571" ], "modifiers": [ [ "species_10528334", "catalyst" ] ], "additional_components": [ "WBGene00006783" ] }, "reaction_10529192": { "compartment": "compartment_917758", "id": "reaction_10529192", "reactome": "R-CEL-917744", "name": "GABA loaded synaptic vesicle Docking and Priming", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10528366", "species_10516749", "species_10516744", "species_10516631", "species_10516739", "species_10516754" ], "products": [ "species_10528368" ], "modifiers": [ [ "species_10528366", "catalyst" ] ], "additional_components": [ "G5EDB7", "WBGene00006762", "E5QCE7", "WBGene00001032", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q19767", "WBGene00004898", "Q94057", "WBGene00044062", "Q95XH1", "WBGene00022077", "G5EBK2", "WBGene00014084", "P09446", "WBGene00002005", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "Q94986", "WBGene00004267", "species_352003", "P34579", "WBGene00006783", "WBGene00006798", "WBGene00022271", "WBGene00006757", "G5EEN8", "WBGene00006454", "A5PEW5", "WBGene00004364", "WBGene00006750", "Q22366", "WBGene00006750", "G5EEN8", "WBGene00006454", "A5PEW5", "WBGene00004364", "P34815", "WBGene00006757", "Q9GUM7", "WBGene00022271", "O16000", "WBGene00006798", "G5EDB7", "WBGene00006762", "E5QCE7", "WBGene00001032", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q19767", "WBGene00004898", "Q94057", "WBGene00044062", "Q95XH1", "WBGene00022077", "G5EBK2", "WBGene00014084", "P09446", "WBGene00002005", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "Q94986", "WBGene00004267", "species_352003", "P34579", "WBGene00006783", "G5EDB7", "WBGene00006762", "E5QCE7", "WBGene00001032", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q19767", "WBGene00004898", "Q94057", "WBGene00044062", "Q95XH1", "WBGene00022077", "G5EBK2", "WBGene00014084", "P09446", "WBGene00002005", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "Q94986", "WBGene00004267", "species_352003", "P34579", "WBGene00006783" ] }, "reaction_10528325": { "compartment": "compartment_917757", "id": "reaction_10528325", "reactome": "R-CEL-888577", "name": "Synthesis of GABA by GAD2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29404", "species_70106" ], "products": [ "species_352011", "species_113528" ], "modifiers": [ [ "species_10528322", "catalyst" ] ], "additional_components": [ "G5EDB7", "WBGene00006762" ] }, "reaction_10528313": { "compartment": "compartment_70101", "id": "reaction_10528313", "reactome": "R-CEL-888572", "name": "PXLP-K405-GAD1 decarboxylates L-Glu to form GABA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29404", "species_70106" ], "products": [ "species_352011", "species_113528" ], "modifiers": [ [ "species_10528310", "catalyst" ] ], "additional_components": [ "G5EDB7", "WBGene00006762" ] }, "reaction_10511628": { "compartment": "compartment_70101", "id": "reaction_10511628", "reactome": "R-CEL-174124", "name": "Dephosphorylation of phospho-Cdh1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10511618" ], "products": [ "species_111294", "species_10511606" ], "modifiers": [ [ "species_10511625", "catalyst" ] ], "additional_components": [ "WBGene00001510", "WBGene00001510" ] }, "reaction_10563824": { "compartment": "compartment_70101", "id": "reaction_10563824", "reactome": "R-CEL-6810843", "name": "Envoplakin binds periplakin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10563820", "species_10563818" ], "products": [ "species_10563822" ], "modifiers": [], "additional_components": [ "WBGene00006876", "WBGene00006876", "A0A1N7SYP3", "WBGene00006876" ] }, "reaction_10564246": { "compartment": "compartment_876", "id": "reaction_10564246", "reactome": "R-CEL-6814187", "name": "EVL:PPL heterodimer binds the inner surface of the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10563822", "species_983438" ], "products": [ "species_10563826" ], "modifiers": [], "additional_components": [ "A0A1N7SYP3", "WBGene00006876", "A0A1N7SYP3", "WBGene00006876" ] }, "reaction_10564473": { "compartment": "compartment_876", "id": "reaction_10564473", "reactome": "R-CEL-6814695", "name": "PERP binds desmosomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10564455", "species_10564469" ], "products": [ "species_10564471" ], "modifiers": [], "additional_components": [ "WBGene00006875", "Q19319", "WBGene00000396", "A0A1N7SYP3", "WBGene00006876", "Q10953", "WBGene00006943", "Q18825", "WBGene00000238", "O44326", "WBGene00001979", "Q9U308", "WBGene00002175", "Q19319", "WBGene00000396", "A0A1N7SYP3", "WBGene00006876", "Q10953", "WBGene00006943", "Q18825", "WBGene00000238", "O44326", "WBGene00001979", "Q9U308", "WBGene00002175", "G5ED30", "WBGene00006875" ] }, "reaction_10558492": { "compartment": "compartment_984", "id": "reaction_10558492", "reactome": "R-CEL-6789310", "name": "LIPs hydrolyse TG to DAG and RCOOH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_171126" ], "products": [ "species_174675", "species_6789319" ], "modifiers": [ [ "species_10558489", "catalyst" ] ], "additional_components": [ "O16956", "WBGene00020016", "Q20449", "WBGene00009773", "Q93789", "WBGene00010062", "O17766", "WBGene00008510", "O61866", "WBGene00022642", "Q94252", "WBGene00019376", "E2S7J2", "WBGene00021963", "Q9U276", "WBGene00013050" ] }, "reaction_10571492": { "compartment": "compartment_70101", "id": "reaction_10571492", "reactome": "R-CEL-9020270", "name": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_9024577" ], "products": [ "species_9024570" ], "modifiers": [ [ "species_10517863", "catalyst" ] ], "additional_components": [ "CHEBI:138615", "CHEBI:138616", "species_216785", "G5EFT4", "WBGene00016589" ] }, "reaction_10571494": { "compartment": "compartment_70101", "id": "reaction_10571494", "reactome": "R-CEL-9020271", "name": "GPX4-2 reduces 17(R)-Hp-DHA to 17(R)-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29450", "species_9024522" ], "products": [ "species_29356", "species_9024463", "species_111745" ], "modifiers": [ [ "species_10571475", "catalyst" ] ], "additional_components": [ "WBGene00019846" ] }, "reaction_10571484": { "compartment": "compartment_70101", "id": "reaction_10571484", "reactome": "R-CEL-9020252", "name": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_9024602" ], "products": [ "species_9024574" ], "modifiers": [ [ "species_10517863", "catalyst" ] ], "additional_components": [ "CHEBI:138179", "CHEBI:138614", "species_216785", "G5EFT4", "WBGene00016589" ] }, "reaction_10571490": { "compartment": "compartment_70101", "id": "reaction_10571490", "reactome": "R-CEL-9020258", "name": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_9024768" ], "products": [ "species_9024759" ], "modifiers": [ [ "species_10517863", "catalyst" ] ], "additional_components": [ "CHEBI:81565", "CHEBI:81564", "species_216785", "G5EFT4", "WBGene00016589" ] }, "reaction_10571496": { "compartment": "compartment_70101", "id": "reaction_10571496", "reactome": "R-CEL-9020273", "name": "GPX4-2 reduces 17(S)-Hp-DHA to 17(S)-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29450", "species_9024012" ], "products": [ "species_29356", "species_9024815", "species_111745" ], "modifiers": [ [ "species_10571475", "catalyst" ] ], "additional_components": [ "WBGene00019846" ] }, "reaction_10571486": { "compartment": "compartment_70101", "id": "reaction_10571486", "reactome": "R-CEL-9020253", "name": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(S)-HDHA to RvD3 or RvD4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_9024781" ], "products": [ "species_9024809" ], "modifiers": [ [ "species_10517863", "catalyst" ] ], "additional_components": [ "CHEBI:138649", "CHEBI:138648", "species_216785", "G5EFT4", "WBGene00016589" ] }, "reaction_10571488": { "compartment": "compartment_70101", "id": "reaction_10571488", "reactome": "R-CEL-9020257", "name": "LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_9024893" ], "products": [ "species_9024879" ], "modifiers": [ [ "species_10517863", "catalyst" ] ], "additional_components": [ "species_216785", "G5EFT4", "WBGene00016589" ] }, "reaction_10571541": { "compartment": "compartment_70101", "id": "reaction_10571541", "reactome": "R-CEL-9024890", "name": "LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_9024873" ], "products": [ "species_9024886" ], "modifiers": [ [ "species_10517863", "catalyst" ] ], "additional_components": [ "species_216785", "G5EFT4", "WBGene00016589" ] }, "reaction_10555584": { "compartment": "compartment_7660", "id": "reaction_10555584", "reactome": "R-CEL-5683792", "name": "p-T68-CHEK2 autophosphorylates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10555579" ], "products": [ "species_113582", "species_10502800" ], "modifiers": [ [ "species_10555579", "catalyst" ] ], "additional_components": [ "Q9U1Y5", "WBGene00000499", "WBGene00000499", "Q9U1Y5", "WBGene00000499" ] }, "reaction_10555635": { "compartment": "compartment_7660", "id": "reaction_10555635", "reactome": "R-CEL-5683964", "name": "ATM phosphorylates EYA1-4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10555610" ], "products": [ "species_113582", "species_10555619" ], "modifiers": [ [ "species_10555632", "catalyst" ] ], "additional_components": [ "WBGene00001377", "WBGene00001377", "Q9TYU5", "WBGene00007029", "Q23255", "WBGene00003405", "O44199", "WBGene00004296", "P62784", "WBGene00001875", "Q19649", "WBGene00017638", "Q23429", "WBGene00014240" ] }, "reaction_10555638": { "compartment": "compartment_7660", "id": "reaction_10555638", "reactome": "R-CEL-5683967", "name": "EYA1-4 dephosphorylates tyrosine Y142 of H2AFX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10555632" ], "products": [ "species_113550", "species_10555554" ], "modifiers": [ [ "species_10555619", "catalyst" ] ], "additional_components": [ "Q9TYU5", "WBGene00007029", "Q23255", "WBGene00003405", "O44199", "WBGene00004296", "P62784", "WBGene00001875", "Q19649", "WBGene00017638", "Q23429", "WBGene00014240", "P62784", "WBGene00001875", "Q19649", "WBGene00017638", "Q23429", "WBGene00014240", "Q9TYU5", "WBGene00007029", "Q23255", "WBGene00003405", "O44199", "WBGene00004296", "WBGene00001377" ] }, "reaction_10556984": { "compartment": "compartment_7660", "id": "reaction_10556984", "reactome": "R-CEL-5693536", "name": "ATM phosphorylates MDC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10556981" ], "products": [ "species_113582", "species_10555565" ], "modifiers": [ [ "species_10556981", "catalyst" ] ], "additional_components": [ "Q9U370", "WBGene00004031", "P62784", "WBGene00001875", "Q19649", "WBGene00017638", "Q23429", "WBGene00014240", "Q9TYU5", "WBGene00007029", "Q23255", "WBGene00003405", "O44199", "WBGene00004296", "P62784", "WBGene00001875", "Q19649", "WBGene00017638", "Q23429", "WBGene00014240", "Q9TYU5", "WBGene00007029", "Q23255", "WBGene00003405", "O44199", "WBGene00004296", "Q9U370", "WBGene00004031", "Q9U370", "WBGene00004031", "P62784", "WBGene00001875", "Q19649", "WBGene00017638", "Q23429", "WBGene00014240", "Q9TYU5", "WBGene00007029", "Q23255", "WBGene00003405", "O44199", "WBGene00004296" ] }, "reaction_10556989": { "compartment": "compartment_7660", "id": "reaction_10556989", "reactome": "R-CEL-5693549", "name": "ATM phosphorylates histone H2AFX on S139 at DNA DSBs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10556986" ], "products": [ "species_113582", "species_10555632" ], "modifiers": [ [ "species_10556986", "catalyst" ] ], "additional_components": [ "P62784", "WBGene00001875", "Q23429", "WBGene00014240", "Q19649", "WBGene00017638", "Q9TYU5", "WBGene00007029", "Q23255", "WBGene00003405", "O44199", "WBGene00004296", "Q9TYU5", "WBGene00007029", "Q23255", "WBGene00003405", "O44199", "WBGene00004296", "P62784", "WBGene00001875", "Q19649", "WBGene00017638", "Q23429", "WBGene00014240", "P62784", "WBGene00001875", "Q23429", "WBGene00014240", "Q19649", "WBGene00017638", "Q9TYU5", "WBGene00007029", "Q23255", "WBGene00003405", "O44199", "WBGene00004296" ] }, "reaction_10555581": { "compartment": "compartment_7660", "id": "reaction_10555581", "reactome": "R-CEL-5683774", "name": "p-T68-CHEK2 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10555577" ], "products": [ "species_10555579" ], "modifiers": [], "additional_components": [ "WBGene00000499", "Q9U1Y5", "WBGene00000499" ] }, "reaction_10555647": { "compartment": "compartment_7660", "id": "reaction_10555647", "reactome": "R-CEL-5683986", "name": "APBB1 and MAPK8 bind diphosphorylated H2AFX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10555643", "species_10510872", "species_10555632" ], "products": [ "species_10555645" ], "modifiers": [], "additional_components": [ "WBGene00001410", "WBGene00002178", "Q9TYU5", "WBGene00007029", "Q23255", "WBGene00003405", "O44199", "WBGene00004296", "P62784", "WBGene00001875", "Q19649", "WBGene00017638", "Q23429", "WBGene00014240", "Q9TYU5", "WBGene00007029", "Q23255", "WBGene00003405", "O44199", "WBGene00004296", "P62784", "WBGene00001875", "Q19649", "WBGene00017638", "Q23429", "WBGene00014240", "Q8WQG9", "WBGene00002178", "Q9BKZ9", "WBGene00001410" ] }, "reaction_10556991": { "compartment": "compartment_7660", "id": "reaction_10556991", "reactome": "R-CEL-5693583", "name": "MDC1 associates with gamma-H2AFX at nuclear foci", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10555554", "species_10556979" ], "products": [ "species_10556981" ], "modifiers": [], "additional_components": [ "P62784", "WBGene00001875", "Q19649", "WBGene00017638", "Q23429", "WBGene00014240", "Q9TYU5", "WBGene00007029", "Q23255", "WBGene00003405", "O44199", "WBGene00004296", "Q9U370", "WBGene00004031", "Q9U370", "WBGene00004031", "P62784", "WBGene00001875", "Q19649", "WBGene00017638", "Q23429", "WBGene00014240", "Q9TYU5", "WBGene00007029", "Q23255", "WBGene00003405", "O44199", "WBGene00004296" ] }, "reaction_10566033": { "compartment": "compartment_70101", "id": "reaction_10566033", "reactome": "R-CEL-8863723", "name": "COP9 and TOR1 deneddylate STON2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10566028" ], "products": [ "species_10566026", "species_10566008", "species_10565943", "species_10556642" ], "modifiers": [ [ "species_10566028", "catalyst" ] ], "additional_components": [ "P90761", "WBGene00006777", "Q95NU5", "WBGene00003870", "Q9N359", "WBGene00000816", "P91001", "WBGene00000817", "Q95PZ0", "WBGene00000818", "Q9GS00", "WBGene00000813", "O01422", "WBGene00000814", "Q9N425", "WBGene00000815", "Q9N359", "WBGene00000816", "P91001", "WBGene00000817", "Q95PZ0", "WBGene00000818", "Q9GS00", "WBGene00000813", "O01422", "WBGene00000814", "Q9N425", "WBGene00000815", "Q95NU5", "WBGene00003870", "WBGene00006777", "WBGene00003587", "P90761", "WBGene00006777", "Q95NU5", "WBGene00003870", "Q9N359", "WBGene00000816", "P91001", "WBGene00000817", "Q95PZ0", "WBGene00000818", "Q9GS00", "WBGene00000813", "O01422", "WBGene00000814", "Q9N425", "WBGene00000815" ] }, "reaction_10566256": { "compartment": "compartment_876", "id": "reaction_10566256", "reactome": "R-CEL-8866277", "name": "AP-2 directly binds some endocytic cargo", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10548814", "species_10566250" ], "products": [ "species_10566252" ], "modifiers": [ [ "species_10566254", "inhibitor" ] ], "additional_components": [ "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q95QV2", "WBGene00000477", "Q19625", "WBGene00003412", "P34711", "WBGene00006756", "Q9XTT3", "WBGene00013039", "Q95QV2", "WBGene00000477", "Q19625", "WBGene00003412", "P34711", "WBGene00006756", "Q9XTT3", "WBGene00013039", "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "P35603", "WBGene00001082", "Q19123", "WBGene00000157" ] }, "reaction_10566272": { "compartment": "compartment_876", "id": "reaction_10566272", "reactome": "R-CEL-8866283", "name": "ARBB recruits GPCRs into clathrin-coated pits", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10566213", "species_10565777" ], "products": [ "species_10566270" ], "modifiers": [ [ "species_10566234", "inhibitor" ] ], "additional_components": [ "Q9N532", "WBGene00003238", "G5EDV1", "WBGene00003006", "P34889", "WBGene00000858", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "Q9U7D5", "WBGene00001519", "P51485", "WBGene00000195", "G5ECQ3", "WBGene00004762", "Q20483", "WBGene00018516", "Q9BIF4", "WBGene00001224", "species_179856", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "Q9TXS0", "WBGene00018974", "Q9N489", "WBGene00022453", "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "Q19123", "WBGene00000157", "P35603", "WBGene00001082", "A0A0K3AS36", "Y116A8C.36d", "G5ECQ3", "WBGene00004762", "Q20483", "WBGene00018516", "Q9BIF4", "WBGene00001224", "species_179856", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "Q9TXS0", "WBGene00018974", "Q9N489", "WBGene00022453", "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "Q19123", "WBGene00000157", "P35603", "WBGene00001082", "A0A0K3AS36", "Y116A8C.36d", "Q9N532", "WBGene00003238", "G5EDV1", "WBGene00003006", "P34889", "WBGene00000858", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "Q9U7D5", "WBGene00001519", "P51485", "WBGene00000195", "Q9BIF4", "WBGene00001224", "Q18453", "WBGene00004682", "Q9BI71", "WBGene00001329", "G5EFF7", "WBGene00008852" ] }, "reaction_10566035": { "compartment": "compartment_70101", "id": "reaction_10566035", "reactome": "R-CEL-8863727", "name": "STON2 is neddylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10565943", "species_10556642" ], "products": [ "species_10565990" ], "modifiers": [], "additional_components": [ "WBGene00006777", "WBGene00003587", "WBGene00006777" ] }, "reaction_10566371": { "compartment": "compartment_876", "id": "reaction_10566371", "reactome": "R-CEL-8867613", "name": "PICALM binds R-SNAREs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10566365", "species_10566363" ], "products": [ "species_10566369" ], "modifiers": [], "additional_components": [ "WBGene00006751", "Q95XH1", "WBGene00022077", "G5EBK2", "WBGene00014084", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q19767", "WBGene00004898", "Q94057", "WBGene00044062", "Q95XH1", "WBGene00022077", "G5EBK2", "WBGene00014084", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q19767", "WBGene00004898", "Q94057", "WBGene00044062", "Q9XZI6", "WBGene00006751" ] }, "reaction_10573106": { "compartment": "compartment_70101", "id": "reaction_10573106", "reactome": "R-CEL-9681616", "name": "AP2 binds chlorpromazine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9648300", "species_10548814" ], "products": [ "species_10566254" ], "modifiers": [], "additional_components": [ "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "P35603", "WBGene00001082", "Q19123", "WBGene00000157" ] }, "reaction_10566215": { "compartment": "compartment_876", "id": "reaction_10566215", "reactome": "R-CEL-8866269", "name": "ARRB bind GPCRs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10521710", "species_10566211" ], "products": [ "species_10566213" ], "modifiers": [], "additional_components": [ "WBGene00000195", "Q9N532", "WBGene00003238", "G5EDV1", "WBGene00003006", "P34889", "WBGene00000858", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "Q9U7D5", "WBGene00001519", "Q9N532", "WBGene00003238", "G5EDV1", "WBGene00003006", "P34889", "WBGene00000858", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "Q9U7D5", "WBGene00001519", "P51485", "WBGene00000195" ] }, "reaction_10565949": { "compartment": "compartment_876", "id": "reaction_10565949", "reactome": "R-CEL-8863463", "name": "STON2 binds SYT proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10565943", "species_10565938" ], "products": [ "species_10565947" ], "modifiers": [], "additional_components": [ "WBGene00006777", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "P90761", "WBGene00006777" ] }, "reaction_10566268": { "compartment": "compartment_876", "id": "reaction_10566268", "reactome": "R-CEL-8866279", "name": "Epsin family proteins bind ubiquitinated cargo", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10566232", "species_10566264" ], "products": [ "species_10566266" ], "modifiers": [], "additional_components": [ "Q9BIF4", "WBGene00001224", "Q18453", "WBGene00004682", "Q9BI71", "WBGene00001329", "Q19019", "WBGene00004829", "Q9BIF4", "WBGene00001224", "P24348", "WBGene00002299", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "B1V8A0", "WBGene00006791", "P29355", "WBGene00004774", "Q17796", "WBGene00004101", "O01498", "WBGene00004109", "Q18453", "WBGene00004682", "Q9BI71", "WBGene00001329", "Q9BIF4", "WBGene00001224", "Q18453", "WBGene00004682", "Q9BI71", "WBGene00001329", "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "B1V8A0", "WBGene00006791", "P29355", "WBGene00004774", "Q17796", "WBGene00004101", "O01498", "WBGene00004109" ] }, "reaction_10566236": { "compartment": "compartment_70101", "id": "reaction_10566236", "reactome": "R-CEL-8866275", "name": "UBQLNs bind UIM-containing adaptor proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10566220", "species_10566232" ], "products": [ "species_10566234" ], "modifiers": [], "additional_components": [ "WBGene00008852", "Q9BIF4", "WBGene00001224", "Q18453", "WBGene00004682", "Q9BI71", "WBGene00001329", "Q9BIF4", "WBGene00001224", "Q18453", "WBGene00004682", "Q9BI71", "WBGene00001329", "G5EFF7", "WBGene00008852" ] }, "reaction_10565967": { "compartment": "compartment_876", "id": "reaction_10565967", "reactome": "R-CEL-8863472", "name": "DAB2 binds LRP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10565951", "species_10565963" ], "products": [ "species_10565965" ], "modifiers": [], "additional_components": [ "WBGene00000894", "Q21496", "WBGene00020010", "Q21948", "WBGene00020010", "Q21496", "WBGene00020010", "Q21948", "WBGene00020010", "A0A486WXX8", "WBGene00000894" ] }, "reaction_10566030": { "compartment": "compartment_70101", "id": "reaction_10566030", "reactome": "R-CEL-8863721", "name": "NEDD8-STON binds TOR1 hexamer and COP9 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10566026", "species_10566008", "species_10565990" ], "products": [ "species_10566028" ], "modifiers": [], "additional_components": [ "Q9N359", "WBGene00000816", "P91001", "WBGene00000817", "Q95PZ0", "WBGene00000818", "Q9GS00", "WBGene00000813", "O01422", "WBGene00000814", "Q9N425", "WBGene00000815", "Q95NU5", "WBGene00003870", "WBGene00006777", "P90761", "WBGene00006777", "Q95NU5", "WBGene00003870", "Q9N359", "WBGene00000816", "P91001", "WBGene00000817", "Q95PZ0", "WBGene00000818", "Q9GS00", "WBGene00000813", "O01422", "WBGene00000814", "Q9N425", "WBGene00000815" ] }, "reaction_10506050": { "compartment": "compartment_70101", "id": "reaction_10506050", "reactome": "R-CEL-73571", "name": "CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111628", "species_70106" ], "products": [ "species_29356", "species_76630" ], "modifiers": [ [ "species_10506047", "catalyst" ] ], "additional_components": [ "Q18990", "WBGene00004259" ] }, "reaction_10506053": { "compartment": "compartment_70101", "id": "reaction_10506053", "reactome": "R-CEL-73573", "name": "CAD hexamer transforms CAP to N-carb-L-Asp", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111647", "species_29448" ], "products": [ "species_111628", "species_29372" ], "modifiers": [ [ "species_10506047", "catalyst" ] ], "additional_components": [ "Q18990", "WBGene00004259" ] }, "reaction_10506056": { "compartment": "compartment_70101", "id": "reaction_10506056", "reactome": "R-CEL-73577", "name": "CAD hexamer transforms L-Gln to CAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_111627", "species_113592", "species_29472" ], "products": [ "species_111647", "species_29372", "species_29404", "species_29370" ], "modifiers": [ [ "species_10506047", "catalyst" ] ], "additional_components": [ "Q18990", "WBGene00004259" ] }, "reaction_10506040": { "compartment": "compartment_70101", "id": "reaction_10506040", "reactome": "R-CEL-73569", "name": "DHODH:FMN oxidises (S)-DHO to orotate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73663", "species_76630" ], "products": [ "species_76632", "species_76633" ], "modifiers": [ [ "species_10506037", "catalyst" ] ], "additional_components": [ "O01815", "WBGene00020932", "species_73524" ] }, "reaction_10506027": { "compartment": "compartment_70101", "id": "reaction_10506027", "reactome": "R-CEL-73564", "name": "UMPS dimer decarboxylates OMP to UMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111629" ], "products": [ "species_109402", "species_113528" ], "modifiers": [ [ "species_10506024", "catalyst" ] ], "additional_components": [ "G5EDZ2", "WBGene00011559" ] }, "reaction_10506030": { "compartment": "compartment_70101", "id": "reaction_10506030", "reactome": "R-CEL-73567", "name": "UMPS dimer transfers phoshoribosyl group to ORO to form OMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73566", "species_76632" ], "products": [ "species_111294", "species_111629" ], "modifiers": [ [ "species_10506024", "catalyst" ] ], "additional_components": [ "G5EDZ2", "WBGene00011559" ] }, "reaction_10508834": { "compartment": "compartment_70101", "id": "reaction_10508834", "reactome": "R-CEL-111285", "name": "Formation of phosphoribosyl pyrophosphate amidotransferase tetramer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10506404" ], "products": [ "species_10508832" ], "modifiers": [ [ "species_113578", "catalyst" ], [ "species_29602", "catalyst" ], [ "species_76577", "catalyst" ] ], "additional_components": [ "Q22134", "WBGene00011407", "CHEBI:17909", "species_113531", "Q22134", "WBGene00011407", "CHEBI:17909", "species_113531" ] }, "reaction_10508866": { "compartment": "compartment_70101", "id": "reaction_10508866", "reactome": "R-CEL-111524", "name": "IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_29448", "species_29602" ], "products": [ "species_29372", "species_29420", "species_35141" ], "modifiers": [ [ "species_10508863", "catalyst" ], [ "species_29420", "inhibitor" ], [ "species_30014", "inhibitor" ], [ "species_113578", "inhibitor" ], [ "species_35141", "inhibitor" ] ], "additional_components": [ "P91134", "WBGene00016509", "species_114632" ] }, "reaction_10508836": { "compartment": "compartment_70101", "id": "reaction_10508836", "reactome": "R-CEL-111289", "name": "Dissociation of phosphoribosyl pyrophosphate amidotransferase tetramer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508832" ], "products": [ "species_10506404" ], "modifiers": [ [ "species_73566", "catalyst" ] ], "additional_components": [ "Q22134", "WBGene00011407", "CHEBI:17909", "species_113531", "Q22134", "WBGene00011407", "CHEBI:17909", "species_113531" ] }, "reaction_10506340": { "compartment": "compartment_70101", "id": "reaction_10506340", "reactome": "R-CEL-73792", "name": "XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_111584", "species_29472" ], "products": [ "species_111294", "species_29404", "species_113578", "species_76577" ], "modifiers": [ [ "species_10506337", "catalyst" ] ], "additional_components": [ "WBGene00010912" ] }, "reaction_10506407": { "compartment": "compartment_70101", "id": "reaction_10506407", "reactome": "R-CEL-73815", "name": "5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73566", "species_29356", "species_29472" ], "products": [ "species_111294", "species_111292", "species_29404" ], "modifiers": [ [ "species_10506404", "catalyst" ] ], "additional_components": [ "Q22134", "WBGene00011407", "CHEBI:17909", "species_113531" ] }, "reaction_10506376": { "compartment": "compartment_70101", "id": "reaction_10506376", "reactome": "R-CEL-73800", "name": "SAICAR => AICAR + Fumarate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111399" ], "products": [ "species_29586", "species_111409" ], "modifiers": [ [ "species_10506373", "catalyst" ] ], "additional_components": [ "Q21774", "WBGene00011064" ] }, "reaction_10506409": { "compartment": "compartment_70101", "id": "reaction_10506409", "reactome": "R-CEL-73828", "name": "adenylosuccinate => adenosine 5'-monophosphate + fumarate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_35141" ], "products": [ "species_29586", "species_76577" ], "modifiers": [ [ "species_10506373", "catalyst" ] ], "additional_components": [ "Q21774", "WBGene00011064" ] }, "reaction_10506352": { "compartment": "compartment_70101", "id": "reaction_10506352", "reactome": "R-CEL-73794", "name": "IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_29602", "species_29360" ], "products": [ "species_70106", "species_111584", "species_73473" ], "modifiers": [ [ "species_10506347", "catalyst" ], [ "species_111584", "inhibitor" ], [ "species_10506350", "inhibitor" ] ], "additional_components": [ "Q9GZH3", "WBGene00020682", "Q9GZH3", "WBGene00020682" ] }, "reaction_10506386": { "compartment": "compartment_70101", "id": "reaction_10506386", "reactome": "R-CEL-73805", "name": "CAIR + Aspartate + ATP => SAICAR + ADP + Pi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_29448", "species_111395" ], "products": [ "species_29372", "species_29370", "species_111399" ], "modifiers": [ [ "species_10506383", "catalyst" ] ], "additional_components": [ "Q10457", "WBGene00015116" ] }, "reaction_10506389": { "compartment": "compartment_70101", "id": "reaction_10506389", "reactome": "R-CEL-73806", "name": "AIR + CO2 => CAIR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111370", "species_113528" ], "products": [ "species_111395" ], "modifiers": [ [ "species_10506383", "catalyst" ] ], "additional_components": [ "Q10457", "WBGene00015116" ] }, "reaction_10506363": { "compartment": "compartment_70101", "id": "reaction_10506363", "reactome": "R-CEL-73797", "name": "FAICAR => IMP + H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111427" ], "products": [ "species_29356", "species_29602" ], "modifiers": [ [ "species_10506360", "catalyst" ] ], "additional_components": [ "Q95QQ4", "WBGene00016957" ] }, "reaction_10558365": { "compartment": "compartment_70101", "id": "reaction_10558365", "reactome": "R-CEL-6788912", "name": "LHPP:Mg2+ dimer hydrolyses PPi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111294", "species_29356" ], "products": [ "species_29372" ], "modifiers": [ [ "species_10558362", "catalyst" ] ], "additional_components": [ "species_114632", "O01926", "WBGene00007548" ] }, "reaction_10506397": { "compartment": "compartment_70101", "id": "reaction_10506397", "reactome": "R-CEL-73812", "name": "FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_111354", "species_113592", "species_29472" ], "products": [ "species_29372", "species_29404", "species_29370", "species_111369" ], "modifiers": [ [ "species_10506394", "catalyst" ] ], "additional_components": [ "WBGene00008654" ] }, "reaction_10573084": { "compartment": "compartment_70101", "id": "reaction_10573084", "reactome": "R-CEL-9678749", "name": "IMPDH tetramers binds IMPDH inhibitors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9678719", "species_10506347" ], "products": [ "species_10506350" ], "modifiers": [], "additional_components": [ "Q9GZH3", "WBGene00020682", "Q9GZH3", "WBGene00020682" ] }, "reaction_10506366": { "compartment": "compartment_70101", "id": "reaction_10506366", "reactome": "R-CEL-73798", "name": "AICAR + 10-Formyl-THF => FAICAR + THF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_419151", "species_111409" ], "products": [ "species_111355", "species_111427" ], "modifiers": [ [ "species_10506360", "catalyst" ] ], "additional_components": [ "Q95QQ4", "WBGene00016957" ] }, "reaction_10573092": { "compartment": "compartment_876", "id": "reaction_10573092", "reactome": "R-CEL-9679740", "name": "ITGA4:ITGB1 binds natalizumab", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10514207", "species_9679737" ], "products": [ "species_10573090" ], "modifiers": [], "additional_components": [ "Q27874", "WBGene00003930", "P34446", "WBGene00003929", "Q27874", "WBGene00003930", "P34446", "WBGene00003929" ] }, "reaction_10515321": { "compartment": "compartment_876", "id": "reaction_10515321", "reactome": "R-CEL-202723", "name": "Integrin alpha5beta1 binds FN1 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_266099", "species_10515317", "species_10515313" ], "products": [ "species_10515319" ], "modifiers": [], "additional_components": [ "P34446", "WBGene00003929", "Q27874", "WBGene00003930", "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769", "P34446", "WBGene00003929", "Q27874", "WBGene00003930", "species_266099" ] }, "reaction_10515290": { "compartment": "compartment_876", "id": "reaction_10515290", "reactome": "R-CEL-202710", "name": "MERTK receptor binds ligands (Gas6 or Protein S)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10515286", "species_10515280" ], "products": [ "species_10515288" ], "modifiers": [], "additional_components": [ "G5EFX3", "WBGene00013416", "Q9XWD6", "WBGene00000415", "WBGene00008711", "Q9XVQ7", "WBGene00008711", "G5EFX3", "WBGene00013416", "Q9XWD6", "WBGene00000415" ] }, "reaction_10545950": { "compartment": "compartment_876", "id": "reaction_10545950", "reactome": "R-CEL-2870221", "name": "E-selectin binds E-selectin ligand", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10545946", "species_10545941" ], "products": [ "species_10545948" ], "modifiers": [], "additional_components": [ "WBGene00008800", "Q18849", "WBGene00009500", "Q22328", "WBGene00002976", "A0A1N7SYP5", "WBGene00009500", "Q18849", "WBGene00009500", "Q22328", "WBGene00002976", "A0A1N7SYP5", "WBGene00009500", "Q19459", "WBGene00008800" ] }, "reaction_10572733": { "compartment": "compartment_17957", "id": "reaction_10572733", "reactome": "R-CEL-9650473", "name": "SERPING1 is secreted", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10572731" ], "products": [ "species_10526610" ], "modifiers": [], "additional_components": [ "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "A9Z1L1", "WBGene00005648", "G5ECY2", "WBGene00005644", "Q19651", "WBGene00005649", "A9Z1L1", "WBGene00005648", "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q18287", "WBGene00016187" ] }, "reaction_10509775": { "compartment": "compartment_984", "id": "reaction_10509775", "reactome": "R-CEL-140806", "name": "SERPINC1 binds SERPINC1 activators", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509755", "species_9693058" ], "products": [ "species_10509773" ], "modifiers": [], "additional_components": [ "G5ECY2", "WBGene00005644", "Q18287", "WBGene00016187", "G5EE40", "WBGene00005642", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647", "A9Z1L1", "WBGene00005648", "O17365", "WBGene00005643", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "A9Z1L1", "WBGene00005648", "G5ECY2", "WBGene00005644" ] }, "reaction_10566692": { "compartment": "compartment_12045", "id": "reaction_10566692", "reactome": "R-CEL-8869206", "name": "PAFAH2 hydrolyses PAF to lyso-PAF and acetate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_8869214" ], "products": [ "species_29416", "species_8869207" ], "modifiers": [ [ "species_10566689", "catalyst" ] ], "additional_components": [ "G5EGT1", "WBGene00003906", "Q22943", "WBGene00003907" ] }, "reaction_10523812": { "compartment": "compartment_70101", "id": "reaction_10523812", "reactome": "R-CEL-432148", "name": "Fgr may phosphorylate p38 MAPK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10523344" ], "products": [ "species_10512654", "species_29370" ], "modifiers": [ [ "species_10523809", "catalyst" ] ], "additional_components": [ "WBGene00004055", "WBGene00004055", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635" ] }, "reaction_10509648": { "compartment": "compartment_70101", "id": "reaction_10509648", "reactome": "R-CEL-114683", "name": "Phosphorylation of Platelet Sec-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10509637" ], "products": [ "species_10509645", "species_29370" ], "modifiers": [ [ "species_10509553", "catalyst" ] ], "additional_components": [ "P34815", "WBGene00006757", "O44412", "WBGene00020298", "O44412", "WBGene00020298", "P34815", "WBGene00006757", "species_114519", "P90980", "WBGene00004033", "species_33625", "species_74016" ] }, "reaction_10509555": { "compartment": "compartment_70101", "id": "reaction_10509555", "reactome": "R-CEL-114553", "name": "Activation of conventional Protein Kinase C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_33625", "species_114519", "species_10509044", "species_74016" ], "products": [ "species_10509553" ], "modifiers": [ [ "species_114519", "catalyst" ] ], "additional_components": [ "WBGene00004033", "species_114519", "P90980", "WBGene00004033", "species_33625", "species_74016" ] }, "reaction_10526786": { "compartment": "compartment_876", "id": "reaction_10526786", "reactome": "R-CEL-481010", "name": "Surface deployment of platelet dense granule membrane components", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10526770" ], "products": [ "species_10526784" ], "modifiers": [], "additional_components": [ "G5EBS5", "WBGene00000089", "Q9GYK0", "WBGene00015471", "Q11117", "WBGene00003053", "Q17441", "WBGene00006646", "Q22328", "WBGene00002976", "Q11117", "WBGene00003053", "Q9GYK0", "WBGene00015471", "Q17441", "WBGene00006646", "Q22328", "WBGene00002976", "G5EBS5", "WBGene00000089" ] }, "reaction_10526658": { "compartment": "compartment_876", "id": "reaction_10526658", "reactome": "R-CEL-481007", "name": "Exocytosis of platelet alpha granule contents", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10526516" ], "products": [ "species_10526656" ], "modifiers": [], "additional_components": [ "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769", "A9Z1L1", "WBGene00005648", "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "Q09387", "WBGene00019944", "Q9N413", "WBGene00004249", "K8F7Z5", "WBGene00008735", "Q7YTU0", "WBGene00013969", "G5EFX3", "WBGene00013416", "Q9XWD6", "WBGene00000415", "P34714", "WBGene00003893", "H2KZY5", "WBGene00018533", "G5EEL5", "WBGene00000936", "G5EBY8", "WBGene00006852", "Q21154", "WBGene00019333", "Q18685", "WBGene00006836", "Q10651", "WBGene00000149", "Q18245", "WBGene00007764", "Q23580", "WBGene00022789", "Q9GZE9", "WBGene00017719", "Q9XXG5", "WBGene00006598", "O45271", "WBGene00006597", "Q95NU5", "WBGene00003870", "Q23158", "WBGene00000228", "Q22174", "WBGene00011449", "P91917", "WBGene00012344", "P46563", "WBGene00017166", "P54216", "WBGene00011474", "Q9XWD6", "WBGene00000415", "G5EFX3", "WBGene00013416", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "A9Z1L1", "WBGene00005648", "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "H2KZY5", "WBGene00018533", "K8F7Z5", "WBGene00008735", "Q7YTU0", "WBGene00013969", "Q21154", "WBGene00019333", "Q22174", "WBGene00011449", "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769", "Q9N413", "WBGene00004249", "P91917", "WBGene00012344", "Q23158", "WBGene00000228", "Q09387", "WBGene00019944", "G5EEL5", "WBGene00000936", "G5EBY8", "WBGene00006852", "P34714", "WBGene00003893", "Q10651", "WBGene00000149", "Q18245", "WBGene00007764", "Q23580", "WBGene00022789", "O45271", "WBGene00006597", "Q95NU5", "WBGene00003870", "Q9XXG5", "WBGene00006598", "P46563", "WBGene00017166", "P54216", "WBGene00011474", "Q18685", "WBGene00006836", "Q9GZE9", "WBGene00017719" ] }, "reaction_10523396": { "compartment": "compartment_114584", "id": "reaction_10523396", "reactome": "R-CEL-429157", "name": "ABCC4 accumulation of dense granule contents", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29370" ], "products": [ "species_114565" ], "modifiers": [ [ "species_10523393", "catalyst" ] ], "additional_components": [ "WBGene00003412" ] }, "reaction_10526744": { "compartment": "compartment_876", "id": "reaction_10526744", "reactome": "R-CEL-481009", "name": "Exocytosis of platelet dense granule content", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10526706" ], "products": [ "species_10526742" ], "modifiers": [], "additional_components": [ "species_29438", "species_113582", "species_114632", "O02108", "WBGene00021097", "H2L0F2", "WBGene00019497", "species_29358", "O16454", "WBGene00007055", "Q688B0", "WBGene00019786", "species_29372", "Q19651", "WBGene00005649", "A9Z1L1", "WBGene00005648", "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "species_74016", "A0A1N7SYP5", "WBGene00009500", "Q18849", "WBGene00009500", "Q22328", "WBGene00002976", "species_380585", "species_29420", "species_113541", "species_74016", "Q19651", "WBGene00005649", "A9Z1L1", "WBGene00005648", "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "species_29438", "species_113582", "species_113541", "species_114632", "A0A1N7SYP5", "WBGene00009500", "Q18849", "WBGene00009500", "Q22328", "WBGene00002976", "species_29358", "H2L0F2", "WBGene00019497", "O02108", "WBGene00021097", "O16454", "WBGene00007055", "Q688B0", "WBGene00019786", "species_380585", "species_29372", "species_29420" ] }, "reaction_10526856": { "compartment": "compartment_876", "id": "reaction_10526856", "reactome": "R-CEL-481044", "name": "Surface deployment of platelet alpha granule membrane components", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10526830" ], "products": [ "species_10526854" ], "modifiers": [], "additional_components": [ "Q9N4L6", "WBGene00022836", "Q9XVI4", "WBGene00006633", "P34616", "WBGene00000395", "U4PMB9", "WBGene00021362", "Q22328", "WBGene00002976", "O16521", "WBGene00020268", "O16522", "WBGene00020267", "Q10651", "WBGene00000149", "P91855", "WBGene00009174", "Q7YTU0", "WBGene00013969", "Q9XVI4", "WBGene00006633", "Q10651", "WBGene00000149", "O16522", "WBGene00020267", "O16521", "WBGene00020268", "Q7YTU0", "WBGene00013969", "P34616", "WBGene00000395", "U4PMB9", "WBGene00021362", "P91855", "WBGene00009174", "Q22328", "WBGene00002976", "Q9N4L6", "WBGene00022836" ] }, "reaction_10518043": { "compartment": "compartment_161320", "id": "reaction_10518043", "reactome": "R-CEL-351341", "name": "Exocytosis of Proactivator polypeptide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10518035" ], "products": [ "species_10518041" ], "modifiers": [], "additional_components": [ "Q18607", "WBGene00016642", "Q18276", "WBGene00004995", "Q18607", "WBGene00016642", "Q18276", "WBGene00004995" ] }, "reaction_10527071": { "compartment": "compartment_70101", "id": "reaction_10527071", "reactome": "R-CEL-482772", "name": "Release of platelet cytosolic components", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10526977" ], "products": [ "species_10527069" ], "modifiers": [], "additional_components": [ "P19826", "WBGene00000942", "H2KYR1", "WBGene00006924", "O44412", "WBGene00020298", "P34815", "WBGene00006757", "P52274", "WBGene00006534", "H2L2E8", "WBGene00006528", "P91910", "WBGene00003175", "O18154", "WBGene00006533", "P34690", "WBGene00006529", "G5EDD4", "WBGene00006530", "O17939", "WBGene00010685", "P0DM41", "WBGene00000063", "P0DM42", "WBGene00000065", "P10984", "WBGene00000064", "P10986", "WBGene00000066", "G5EGK1", "WBGene00006771", "P34697", "WBGene00004930", "Q27538", "WBGene00007036", "Q09936", "WBGene00016898", "Q23050", "WBGene00020808", "G5EFB5", "WBGene00000777", "O44788", "WBGene00000778", "D0VWL6", "WBGene00016006", "U4PBJ9", "WBGene00022048", "Q11083", "WBGene00020378", "P04630", "WBGene00000285", "G5EF37", "WBGene00003934", "A0A2C9C3L3", "WBGene00020378", "Q18136", "WBGene00006861", "Q09665", "WBGene00006583", "O02159", "WBGene00020378", "G5EDZ8", "WBGene00000288", "Q94288", "WBGene00000287", "Q09980", "WBGene00017394", "O16305", "WBGene00000552", "G5EEG0", "WBGene00000286", "Q20318", "WBGene00003034", "Q9N3B0", "WBGene00021888", "H2KYR1", "WBGene00006924", "D0VWL6", "WBGene00016006", "U4PBJ9", "WBGene00022048", "A0A2C9C3L3", "WBGene00020378", "Q09980", "WBGene00017394", "G5EDZ8", "WBGene00000288", "Q11083", "WBGene00020378", "G5EEG0", "WBGene00000286", "Q18136", "WBGene00006861", "G5EF37", "WBGene00003934", "Q94288", "WBGene00000287", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "P04630", "WBGene00000285", "Q09665", "WBGene00006583", "G5EGK1", "WBGene00006771", "P19826", "WBGene00000942", "O17939", "WBGene00010685", "G5EDD4", "WBGene00006530", "H2L2E8", "WBGene00006528", "O18154", "WBGene00006533", "P34690", "WBGene00006529", "P52274", "WBGene00006534", "P91910", "WBGene00003175", "O44412", "WBGene00020298", "P34815", "WBGene00006757", "Q27538", "WBGene00007036", "P34697", "WBGene00004930", "Q20318", "WBGene00003034", "G5EFB5", "WBGene00000777", "O44788", "WBGene00000778", "Q09936", "WBGene00016898", "Q23050", "WBGene00020808", "Q9N3B0", "WBGene00021888", "P0DM41", "WBGene00000063", "P0DM42", "WBGene00000065", "P10984", "WBGene00000064", "P10986", "WBGene00000066" ] }, "reaction_10509664": { "compartment": "compartment_70101", "id": "reaction_10509664", "reactome": "R-CEL-114689", "name": "PLC gamma 2-mediated PIP2 hydrolysis", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179856" ], "products": [ "species_114520", "species_114519" ], "modifiers": [ [ "species_10509661", "catalyst" ] ], "additional_components": [ "WBGene00004038" ] }, "reaction_10524321": { "compartment": "compartment_70101", "id": "reaction_10524321", "reactome": "R-CEL-442314", "name": "VAV3 is a GEF for Rho/Rac family kinases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10524313" ], "products": [ "species_29420", "species_10524315" ], "modifiers": [ [ "species_10524318", "catalyst" ] ], "additional_components": [ "Q22038", "WBGene00004357", "Q03206", "ced-10", "species_29420", "Q22038", "WBGene00004357", "Q03206", "ced-10", "species_29438", "WBGene00006887" ] }, "reaction_10523412": { "compartment": "compartment_876", "id": "reaction_10523412", "reactome": "R-CEL-429497", "name": "SLP-76 stimulates PLC gamma 2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10523410" ], "products": [ "species_10509661" ], "modifiers": [], "additional_components": [ "WBGene00004038", "WBGene00004038" ] }, "reaction_10524309": { "compartment": "compartment_70101", "id": "reaction_10524309", "reactome": "R-CEL-442291", "name": "VAV2 is a GEF for Rho/Rac family kinases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10524301" ], "products": [ "species_10524303", "species_29420" ], "modifiers": [ [ "species_10524306", "catalyst" ] ], "additional_components": [ "Q22038", "WBGene00004357", "species_29420", "Q22038", "WBGene00004357", "species_29438", "WBGene00006887" ] }, "reaction_10524295": { "compartment": "compartment_70101", "id": "reaction_10524295", "reactome": "R-CEL-442273", "name": "VAV1 is a GEF for Rho/Rac family GTPases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10524283" ], "products": [ "species_10524285", "species_29420" ], "modifiers": [ [ "species_10524288", "catalyst" ], [ "species_10524293", "catalyst" ], [ "species_10524291", "inhibitor" ] ], "additional_components": [ "Q94124", "WBGene00004287", "Q9BL44", "WBGene00022177", "Q03206", "ced-10", "species_29420", "Q94124", "WBGene00004287", "Q9BL44", "WBGene00022177", "Q03206", "ced-10", "species_29438", "WBGene00006887", "Q45FX5", "WBGene00006887", "species_179838", "species_179856", "Q45FX5", "WBGene00006887" ] }, "reaction_10524234": { "compartment": "compartment_70101", "id": "reaction_10524234", "reactome": "R-CEL-437162", "name": "PI3K alpha, beta, gamma convert PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10506892", "catalyst" ] ], "additional_components": [ "G5EDP9", "WBGene00000001", "Q94125", "WBGene00000090" ] }, "reaction_10521714": { "compartment": "compartment_70101", "id": "reaction_10521714", "reactome": "R-CEL-418091", "name": "F2R binds ARRB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10521710", "species_10521705" ], "products": [ "species_10521712" ], "modifiers": [], "additional_components": [ "WBGene00000195", "WBGene00016570", "H2KZ99", "WBGene00016570", "P51485", "WBGene00000195" ] }, "reaction_10509539": { "compartment": "compartment_70101", "id": "reaction_10509539", "reactome": "R-CEL-114552", "name": "Thrombin-activated PARs activate G12/13", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10509526" ], "products": [ "species_29420", "species_10509536" ], "modifiers": [ [ "species_10509512", "catalyst" ] ], "additional_components": [ "species_29420", "Q19572", "WBGene00001674", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "H2KZ99", "WBGene00016570", "H2KZ99", "WBGene00016570", "Q19572", "WBGene00001674", "species_29438", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "WBGene00016570" ] }, "reaction_10521731": { "compartment": "compartment_70101", "id": "reaction_10521731", "reactome": "R-CEL-418172", "name": "F2R binds ARRB2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10521727", "species_10521705" ], "products": [ "species_10521729" ], "modifiers": [], "additional_components": [ "WBGene00000195", "WBGene00016570", "H2KZ99", "WBGene00016570", "P51485", "WBGene00000195" ] }, "reaction_10521092": { "compartment": "compartment_876", "id": "reaction_10521092", "reactome": "R-CEL-396996", "name": "Thrombin-activated PARs binds G-protein Gq", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509512", "species_10509559" ], "products": [ "species_10509561" ], "modifiers": [], "additional_components": [ "WBGene00016570", "species_29420", "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "species_29420", "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "H2KZ99", "WBGene00016570" ] }, "reaction_10521094": { "compartment": "compartment_876", "id": "reaction_10521094", "reactome": "R-CEL-397835", "name": "Thrombin-activated PARs:Gq (active) dissociate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509563" ], "products": [ "species_10509165", "species_10508937", "species_10509512" ], "modifiers": [], "additional_components": [ "H2KZ99", "WBGene00016570", "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196", "species_29438", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196", "species_29438", "WBGene00016570" ] }, "reaction_10521718": { "compartment": "compartment_70101", "id": "reaction_10521718", "reactome": "R-CEL-418158", "name": "SRC-1 is activated (in F2R:ARRB1:MAPKs:SRC-1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10521716" ], "products": [ "species_10521716" ], "modifiers": [], "additional_components": [ "H2KZ99", "WBGene00016570", "P51485", "WBGene00000195", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "P39745", "WBGene00003401", "H2KZ99", "WBGene00016570", "P51485", "WBGene00000195", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "P39745", "WBGene00003401" ] }, "reaction_10521735": { "compartment": "compartment_70101", "id": "reaction_10521735", "reactome": "R-CEL-418176", "name": "F2R:ARRB2 binds MAPKs, SRC-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508575", "species_10513079", "species_10521729" ], "products": [ "species_10521733" ], "modifiers": [], "additional_components": [ "WBGene00003401", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "H2KZ99", "WBGene00016570", "P51485", "WBGene00000195", "H2KZ99", "WBGene00016570", "P51485", "WBGene00000195", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "P39745", "WBGene00003401" ] }, "reaction_10521737": { "compartment": "compartment_70101", "id": "reaction_10521737", "reactome": "R-CEL-418200", "name": "SRC-1 bound to ARRB2 is not activated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10521733" ], "products": [ "species_10521733" ], "modifiers": [], "additional_components": [ "H2KZ99", "WBGene00016570", "P51485", "WBGene00000195", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "P39745", "WBGene00003401", "H2KZ99", "WBGene00016570", "P51485", "WBGene00000195", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "P39745", "WBGene00003401" ] }, "reaction_10521098": { "compartment": "compartment_876", "id": "reaction_10521098", "reactome": "R-CEL-397891", "name": "Thrombin-activated PARs:G12/13 (active) dissociate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509536" ], "products": [ "species_10509165", "species_10509512", "species_10521096" ], "modifiers": [], "additional_components": [ "H2KZ99", "WBGene00016570", "Q19572", "WBGene00001674", "species_29438", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "WBGene00016570", "Q19572", "WBGene00001674", "species_29438" ] }, "reaction_10521723": { "compartment": "compartment_70101", "id": "reaction_10521723", "reactome": "R-CEL-418163", "name": "Activated SRC-1 activates MAPKs (in F2R:ARRB1:MAPKs:active SRC-1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10521716" ], "products": [ "species_10521720" ], "modifiers": [ [ "species_10521716", "catalyst" ] ], "additional_components": [ "H2KZ99", "WBGene00016570", "P51485", "WBGene00000195", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "P39745", "WBGene00003401", "H2KZ99", "WBGene00016570", "P51485", "WBGene00000195", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "P39745", "WBGene00003401", "H2KZ99", "WBGene00016570", "P51485", "WBGene00000195", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "P39745", "WBGene00003401" ] }, "reaction_10509565": { "compartment": "compartment_70101", "id": "reaction_10509565", "reactome": "R-CEL-114558", "name": "Thrombin-activated PARs activate Gq", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10509561" ], "products": [ "species_29420", "species_10509563" ], "modifiers": [ [ "species_10509512", "catalyst" ] ], "additional_components": [ "species_29420", "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "H2KZ99", "WBGene00016570", "H2KZ99", "WBGene00016570", "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196", "species_29438", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "WBGene00016570" ] }, "reaction_10521725": { "compartment": "compartment_70101", "id": "reaction_10521725", "reactome": "R-CEL-418170", "name": "F2R:ARRB1 binds MAPKs, SRC-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508575", "species_10513079", "species_10521712" ], "products": [ "species_10521716" ], "modifiers": [], "additional_components": [ "WBGene00003401", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "H2KZ99", "WBGene00016570", "P51485", "WBGene00000195", "H2KZ99", "WBGene00016570", "P51485", "WBGene00000195", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "P39745", "WBGene00003401" ] }, "reaction_10528130": { "compartment": "compartment_70101", "id": "reaction_10528130", "reactome": "R-CEL-879459", "name": "F-actin capping protein is a heterodimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10528126", "species_10528121" ], "products": [ "species_10528128" ], "modifiers": [], "additional_components": [ "WBGene00000293", "WBGene00000292", "P34685", "WBGene00000292", "P34686", "WBGene00000293" ] }, "reaction_10531587": { "compartment": "compartment_70101", "id": "reaction_10531587", "reactome": "R-CEL-984606", "name": "Kinesin-5 is a homotetramer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10531494" ], "products": [ "species_10531496" ], "modifiers": [], "additional_components": [ "WBGene00000257", "G5ECF4", "WBGene00000257" ] }, "reaction_10531589": { "compartment": "compartment_70101", "id": "reaction_10531589", "reactome": "R-CEL-984648", "name": "Kinesin-6 and RACGAP1 form the heterotetrameric complex centralspindlin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10531503", "species_10531498" ], "products": [ "species_10531505" ], "modifiers": [], "additional_components": [ "WBGene00000875", "WBGene00006974", "Q8MQ03", "WBGene00006974", "Q9XUS9", "WBGene00000875" ] }, "reaction_10531464": { "compartment": "compartment_70101", "id": "reaction_10531464", "reactome": "R-CEL-983194", "name": "Kinesin-1 is a heterotetramer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10531453", "species_10531458" ], "products": [ "species_10531462" ], "modifiers": [], "additional_components": [ "P46822", "WBGene00002215", "H9G2T2", "WBGene00002214", "WBGene00006840", "P34540", "WBGene00006840", "P46822", "WBGene00002215", "H9G2T2", "WBGene00002214" ] }, "reaction_10531593": { "compartment": "compartment_70101", "id": "reaction_10531593", "reactome": "R-CEL-984733", "name": "Kinesin-3 is a dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10531591" ], "products": [ "species_10531489" ], "modifiers": [], "additional_components": [ "Q965T6", "WBGene00002230", "Q965T6", "WBGene00002230" ] }, "reaction_10531595": { "compartment": "compartment_70101", "id": "reaction_10531595", "reactome": "R-CEL-990489", "name": "Kinesin-13 is a dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10531521" ], "products": [ "species_10531529" ], "modifiers": [], "additional_components": [ "WBGene00002219", "Q9XU12", "WBGene00002219" ] }, "reaction_10531636": { "compartment": "compartment_7660", "id": "reaction_10531636", "reactome": "R-CEL-994106", "name": "HP1 alpha binds Histone H3K9(me)3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10531624", "species_10531632" ], "products": [ "species_10531634" ], "modifiers": [], "additional_components": [ "WBGene00000414", "K7ZUH9", "WBGene00001914", "Q10453", "WBGene00001945", "K7ZUH9", "WBGene00001914", "Q10453", "WBGene00001945", "P34618", "WBGene00000414" ] }, "reaction_10566148": { "compartment": "compartment_70101", "id": "reaction_10566148", "reactome": "R-CEL-8865107", "name": "MICAL1 produces NADP+, H2O2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_29364" ], "products": [ "species_29366", "species_29408" ], "modifiers": [ [ "species_10566145", "catalyst" ] ], "additional_components": [ "species_113596", "A0A061AD47", "WBGene00013289" ] }, "reaction_10531622": { "compartment": "compartment_70101", "id": "reaction_10531622", "reactome": "R-CEL-992708", "name": "Dual-specific AKAPs bind type I and II PKA regulatory subunits", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508956", "species_10531618" ], "products": [ "species_10531620" ], "modifiers": [], "additional_components": [ "P30625", "WBGene00002190", "P21137", "WBGene00002189", "Q10955", "WBGene00004348", "Q09285", "WBGene00016977", "Q10955", "WBGene00004348", "Q09285", "WBGene00016977", "P30625", "WBGene00002190", "P21137", "WBGene00002189" ] }, "reaction_10531606": { "compartment": "compartment_17906", "id": "reaction_10531606", "reactome": "R-CEL-992703", "name": "Mitofusins trans-interact linking mitochondria prior to fusion", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10531600" ], "products": [ "species_10531604" ], "modifiers": [], "additional_components": [ "WBGene00001509", "Q23424", "WBGene00001509" ] }, "reaction_10531750": { "compartment": "compartment_74700", "id": "reaction_10531750", "reactome": "R-CEL-1011600", "name": "Rabenosyn-5 connects Rab5 to VPS-45", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10531741", "species_10531705", "species_10531746" ], "products": [ "species_10531748" ], "modifiers": [], "additional_components": [ "WBGene00004268", "WBGene00021538", "WBGene00016643", "H2KYN0", "WBGene00016643", "W6SBE5", "WBGene00021538", "P91857", "WBGene00004268" ] }, "reaction_10531739": { "compartment": "compartment_70101", "id": "reaction_10531739", "reactome": "R-CEL-1011598", "name": "DOCKs bind to RhoGEFs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10531735", "species_10531733" ], "products": [ "species_10531737" ], "modifiers": [], "additional_components": [ "Q05062", "WBGene00000390", "Q03206", "ced-10", "A0A0K3AR51", "F22G12.5c", "Q20487", "WBGene00018520", "G5EEN3", "WBGene00000419", "A0A0K3AR51", "F22G12.5c", "Q20487", "WBGene00018520", "G5EEN3", "WBGene00000419", "Q05062", "WBGene00000390", "Q03206", "ced-10" ] }, "reaction_10531645": { "compartment": "compartment_70101", "id": "reaction_10531645", "reactome": "R-CEL-994148", "name": "LRRC16A binds F-actin capping protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10531641", "species_10528128" ], "products": [ "species_10531643" ], "modifiers": [], "additional_components": [ "WBGene00010641", "P34685", "WBGene00000292", "P34686", "WBGene00000293", "P34685", "WBGene00000292", "P34686", "WBGene00000293", "Q21301", "WBGene00010641" ] }, "reaction_10531709": { "compartment": "compartment_74700", "id": "reaction_10531709", "reactome": "R-CEL-1011576", "name": "EHD proteins interact with Rabenosyn-5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10531705", "species_10531696" ], "products": [ "species_10531707" ], "modifiers": [], "additional_components": [ "WBGene00021538", "WBGene00004373", "G5ECC3", "WBGene00004373", "W6SBE5", "WBGene00021538" ] }, "reaction_10532193": { "compartment": "compartment_70101", "id": "reaction_10532193", "reactome": "R-CEL-1234163", "name": "Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10532190", "species_10532188" ], "products": [ "species_10532186", "species_10532164" ], "modifiers": [ [ "species_10532190", "catalyst" ] ], "additional_components": [ "species_198836", "G5EBV0", "WBGene00001178", "species_113531", "G5ECR7", "WBGene00001235", "Q19213", "WBGene00006922", "Q9BKS1", "WBGene00001236", "Q23457", "WBGene00004320", "Q17390", "WBGene00000837", "G5EGD2", "WBGene00001851", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "P35129", "WBGene00002344", "P91853", "WBGene00006732", "Q17720", "WBGene00006717", "Q20617", "WBGene00006719", "P35129", "WBGene00002344", "P91853", "WBGene00006732", "Q17720", "WBGene00006717", "Q20617", "WBGene00006719", "species_198836", "G5EBV0", "WBGene00001178", "species_113531", "G5ECR7", "WBGene00001235", "Q19213", "WBGene00006922", "Q9BKS1", "WBGene00001236", "Q23457", "WBGene00004320", "Q17390", "WBGene00000837", "G5EGD2", "WBGene00001851", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "species_198836", "G5EBV0", "WBGene00001178", "species_113531", "G5ECR7", "WBGene00001235", "Q19213", "WBGene00006922", "Q9BKS1", "WBGene00001236", "Q23457", "WBGene00004320", "Q17390", "WBGene00000837", "G5EGD2", "WBGene00001851" ] }, "reaction_10532259": { "compartment": "compartment_7660", "id": "reaction_10532259", "reactome": "R-CEL-1234172", "name": "Nuclear VBC complex ubiquitinylates HIF-alpha", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10532252", "species_10532246" ], "products": [ "species_10511544", "species_10532256" ], "modifiers": [ [ "species_10532246", "catalyst" ] ], "additional_components": [ "P35129", "WBGene00002344", "P91853", "WBGene00006732", "Q17720", "WBGene00006717", "Q20617", "WBGene00006719", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "Q9BKS1", "WBGene00001236", "G5ECR7", "WBGene00001235", "Q19213", "WBGene00006922", "Q23457", "WBGene00004320", "Q17390", "WBGene00000837", "G5EGD2", "WBGene00001851", "P35129", "WBGene00002344", "P91853", "WBGene00006732", "Q17720", "WBGene00006717", "Q20617", "WBGene00006719", "Q9BKS1", "WBGene00001236", "G5ECR7", "WBGene00001235", "Q19213", "WBGene00006922", "Q23457", "WBGene00004320", "Q17390", "WBGene00000837", "G5EGD2", "WBGene00001851", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "Q9BKS1", "WBGene00001236", "G5ECR7", "WBGene00001235", "Q19213", "WBGene00006922", "Q23457", "WBGene00004320", "Q17390", "WBGene00000837", "G5EGD2", "WBGene00001851" ] }, "reaction_10532262": { "compartment": "compartment_70101", "id": "reaction_10532262", "reactome": "R-CEL-1234173", "name": "Cytosolic PHD2,3 hydroxylates proline residues on HIF3A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29406", "species_29368", "species_10532176" ], "products": [ "species_10532141", "species_29434", "species_113528" ], "modifiers": [ [ "species_10532162", "catalyst" ] ], "additional_components": [ "WBGene00001851", "WBGene00001851", "species_198836", "G5EBV0", "WBGene00001178", "species_113531", "G5ECR7", "WBGene00001235", "Q19213", "WBGene00006922", "Q9BKS1", "WBGene00001236", "Q23457", "WBGene00004320", "Q17390", "WBGene00000837" ] }, "reaction_10532214": { "compartment": "compartment_7660", "id": "reaction_10532214", "reactome": "R-CEL-1234165", "name": "Nuclear PHD1,3 hydroxylates proline residues on HIF3A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10532182", "species_113671", "species_113685" ], "products": [ "species_10532201", "species_159942", "species_159939" ], "modifiers": [ [ "species_10532211", "catalyst" ] ], "additional_components": [ "WBGene00001851", "WBGene00001851", "species_113531", "species_198836", "G5EBV0", "WBGene00001178" ] }, "reaction_10532248": { "compartment": "compartment_7660", "id": "reaction_10532248", "reactome": "R-CEL-1234169", "name": "Nuclear VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10532234", "species_10532244" ], "products": [ "species_10532246" ], "modifiers": [], "additional_components": [ "WBGene00001851", "Q9BKS1", "WBGene00001236", "G5ECR7", "WBGene00001235", "Q19213", "WBGene00006922", "Q23457", "WBGene00004320", "Q17390", "WBGene00000837", "Q9BKS1", "WBGene00001236", "G5ECR7", "WBGene00001235", "Q19213", "WBGene00006922", "Q23457", "WBGene00004320", "Q17390", "WBGene00000837", "G5EGD2", "WBGene00001851" ] }, "reaction_10532264": { "compartment": "compartment_70101", "id": "reaction_10532264", "reactome": "R-CEL-1234175", "name": "ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10532256" ], "products": [ "species_10532145" ], "modifiers": [], "additional_components": [ "Q9BKS1", "WBGene00001236", "G5ECR7", "WBGene00001235", "Q19213", "WBGene00006922", "Q23457", "WBGene00004320", "Q17390", "WBGene00000837", "G5EGD2", "WBGene00001851", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "G5ECR7", "WBGene00001235", "Q19213", "WBGene00006922", "Q9BKS1", "WBGene00001236", "Q23457", "WBGene00004320", "Q17390", "WBGene00000837", "G5EGD2", "WBGene00001851", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727" ] }, "reaction_10532266": { "compartment": "compartment_70101", "id": "reaction_10532266", "reactome": "R-CEL-1234177", "name": "Cytosolic PHD2,3 hydroxylates proline residues on HIF1A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29406", "species_10532174", "species_29368" ], "products": [ "species_29434", "species_10532138", "species_113528" ], "modifiers": [ [ "species_10532162", "catalyst" ] ], "additional_components": [ "WBGene00001851", "WBGene00001851", "species_198836", "G5EBV0", "WBGene00001178", "species_113531", "G5ECR7", "WBGene00001235", "Q19213", "WBGene00006922", "Q9BKS1", "WBGene00001236", "Q23457", "WBGene00004320", "Q17390", "WBGene00000837" ] }, "reaction_10532170": { "compartment": "compartment_70101", "id": "reaction_10532170", "reactome": "R-CEL-1234159", "name": "Proteasome proteolyzes ub-HIF-alpha", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10532166" ], "products": [ "species_10532168", "species_10502375" ], "modifiers": [ [ "species_10502572", "catalyst" ] ], "additional_components": [ "G5ECR7", "WBGene00001235", "Q19213", "WBGene00006922", "Q9BKS1", "WBGene00001236", "Q23457", "WBGene00004320", "Q17390", "WBGene00000837", "G5EGD2", "WBGene00001851", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "species_198836", "G5EBV0", "WBGene00001178", "species_113531", "species_198836", "G5EBV0", "WBGene00001178", "species_113531", "G5ECR7", "WBGene00001235", "Q19213", "WBGene00006922", "Q9BKS1", "WBGene00001236", "Q23457", "WBGene00004320", "Q17390", "WBGene00000837", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "P91477", "WBGene00003950", "Q95PZ7", "WBGene00013435", "Q18115", "WBGene00004459", "O62102", "WBGene00003948", "O17071", "WBGene00004504", "Q10920", "WBGene00016623", "P34286", "WBGene00003952", "Q9XTT9", "WBGene00004506", "Q23449", "WBGene00004468", "Q95005", "WBGene00003925", "P46502", "WBGene00004503", "O61792", "WBGene00004464", "O17586", "WBGene00003922", "O76371", "WBGene00004505", "Q20585", "WBGene00004463", "Q95008", "WBGene00003926", "Q18787", "WBGene00004501", "Q20058", "WBGene00009445", "Q9N599", "WBGene00003924", "O16368", "WBGene00004502", "O61742", "WBGene00004466", "Q09583", "WBGene00003928", "Q966I8", "WBGene00003947", "Q04908", "WBGene00004460", "Q9XUV0", "WBGene00003951", "Q27488", "WBGene00003923", "Q9GZH5", "WBGene00004458", "O44156", "WBGene00003927", "Q22253", "WBGene00004465", "O76577", "WBGene00004467", "P90868", "WBGene00003953", "Q19324", "WBGene00004461", "Q17971", "WBGene00007588", "Q23237", "WBGene00003949", "Q20938", "WBGene00004462" ] }, "reaction_10532268": { "compartment": "compartment_7660", "id": "reaction_10532268", "reactome": "R-CEL-1234181", "name": "Nuclear PHD1,3 hydroxylates proline residues on HIF1A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113671", "species_113685", "species_10532180" ], "products": [ "species_10532236", "species_159942", "species_159939" ], "modifiers": [ [ "species_10532211", "catalyst" ] ], "additional_components": [ "WBGene00001851", "WBGene00001851", "species_113531", "species_198836", "G5EBV0", "WBGene00001178" ] }, "reaction_10532270": { "compartment": "compartment_70101", "id": "reaction_10532270", "reactome": "R-CEL-1234183", "name": "Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10532134", "species_10532162" ], "products": [ "species_10532190" ], "modifiers": [], "additional_components": [ "WBGene00001851", "species_198836", "G5EBV0", "WBGene00001178", "species_113531", "G5ECR7", "WBGene00001235", "Q19213", "WBGene00006922", "Q9BKS1", "WBGene00001236", "Q23457", "WBGene00004320", "Q17390", "WBGene00000837", "species_198836", "G5EBV0", "WBGene00001178", "species_113531", "G5ECR7", "WBGene00001235", "Q19213", "WBGene00006922", "Q9BKS1", "WBGene00001236", "Q23457", "WBGene00004320", "Q17390", "WBGene00000837", "G5EGD2", "WBGene00001851" ] }, "reaction_10521058": { "compartment": "compartment_70101", "id": "reaction_10521058", "reactome": "R-CEL-392513", "name": "Rap1 signal termination by Rap1GAPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10518164" ], "products": [ "species_111294", "species_10518265" ], "modifiers": [ [ "species_10521051", "catalyst" ], [ "species_10521056", "inhibitor" ] ], "additional_components": [ "Q18246", "WBGene00004307", "species_29438", "Q18246", "WBGene00004307", "species_29420", "H2L2C2", "WBGene00012100", "H2L055", "WBGene00018734", "H2L055", "WBGene00018734", "Q20655", "WBGene00001502", "P41932", "WBGene00003920" ] }, "reaction_10521090": { "compartment": "compartment_70101", "id": "reaction_10521090", "reactome": "R-CEL-392835", "name": "Rap1 sequesters Raf1 to inhibit ERK cascade", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10521086", "species_10518164" ], "products": [ "species_10521088" ], "modifiers": [], "additional_components": [ "WBGene00003030", "Q18246", "WBGene00004307", "species_29438", "Q18246", "WBGene00004307", "species_29438", "Q07292", "WBGene00003030" ] }, "reaction_10528644": { "compartment": "compartment_70101", "id": "reaction_10528644", "reactome": "R-CEL-913993", "name": "14-3-3 proteins beta and zeta bind and inhibit Rap1Gap2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10521054", "species_10521049" ], "products": [ "species_10521056" ], "modifiers": [ [ "species_10528642", "inhibitor" ] ], "additional_components": [ "Q20655", "WBGene00001502", "P41932", "WBGene00003920", "WBGene00018734", "H2L055", "WBGene00018734", "Q20655", "WBGene00001502", "P41932", "WBGene00003920", "WBGene00018734" ] }, "reaction_10521081": { "compartment": "compartment_70101", "id": "reaction_10521081", "reactome": "R-CEL-392834", "name": "Activation of EPACs by cAMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10520078", "species_30389" ], "products": [ "species_10520080" ], "modifiers": [], "additional_components": [ "WBGene00004255", "species_30389", "P34578", "WBGene00004255" ] }, "reaction_10528655": { "compartment": "compartment_70101", "id": "reaction_10528655", "reactome": "R-CEL-913996", "name": "PKA/PKG phosphorylate Rap1GAP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10521049" ], "products": [ "species_29370", "species_10528642" ], "modifiers": [ [ "species_10528652", "catalyst" ] ], "additional_components": [ "WBGene00018734", "WBGene00018734", "O76360", "WBGene00001173", "P21137", "WBGene00002189" ] }, "reaction_10531425": { "compartment": "compartment_70101", "id": "reaction_10531425", "reactome": "R-CEL-983162", "name": "Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_983036" ], "products": [ "species_983032", "species_8942986" ], "modifiers": [ [ "species_10531422", "catalyst" ] ], "additional_components": [ "Q4TT88", "WBGene00003914", "Q9NAA0", "WBGene00022073", "A5A631", "WBGene00022073", "G5EGH4", "WBGene00022073", "H2L0M5", "WBGene00022073", "Q22317", "WBGene00011587", "Q09541", "WBGene00017686" ] }, "reaction_10531346": { "compartment": "compartment_70101", "id": "reaction_10531346", "reactome": "R-CEL-983156", "name": "Polyubiquitination of substrate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10531247", "species_113592", "species_10531253" ], "products": [ "species_111294", "species_10531245", "species_76577", "species_10531312" ], "modifiers": [ [ "species_10531253", "catalyst" ] ], "additional_components": [ "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "P52478", "WBGene00006701", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "O62235", "WBGene00009477", "Q965X6", "WBGene00021369", "Q9N3T6", "WBGene00021640", "Q9N4I6", "WBGene00022115", "Q94251", "WBGene00001089", "Q17531", "WBGene00007206", "Q17962", "WBGene00007574", "O17324", "WBGene00015673", "Q20367", "WBGene00005013", "Q9GYI0", "WBGene00017920", "O45323", "WBGene00008439", "P34284", "WBGene00015350", "Q6A590", "WBGene00020884", "G5EES6", "WBGene00007333", "Q9N3G1", "WBGene00021815", "Q22071", "WBGene00003177", "G5ECU1", "WBGene00004807", "Q17389", "WBGene00000836", "Q23457", "WBGene00004320", "Q965N7", "WBGene00021596", "Q965N6", "WBGene00021597", "L8E6Y3", "WBGene00016407", "P91133", "WBGene00016326", "Q9BL11", "WBGene00021685", "U4PBY0", "WBGene00022069", "B1Q249", "WBGene00015926", "Q9UAQ3", "WBGene00016539", "A0A061ACQ8", "WBGene00022358", "Q20871", "WBGene00021721", "Q20874", "WBGene00021721", "A8DJA6", "WBGene00021721", "P52478", "WBGene00006701", "O62235", "WBGene00009477", "Q965X6", "WBGene00021369", "Q9N3T6", "WBGene00021640", "Q9N4I6", "WBGene00022115", "Q94251", "WBGene00001089", "Q17531", "WBGene00007206", "Q17962", "WBGene00007574", "O17324", "WBGene00015673", "Q20367", "WBGene00005013", "Q9GYI0", "WBGene00017920", "O45323", "WBGene00008439", "P34284", "WBGene00015350", "Q6A590", "WBGene00020884", "G5EES6", "WBGene00007333", "Q9N3G1", "WBGene00021815", "Q22071", "WBGene00003177", "G5ECU1", "WBGene00004807", "Q17389", "WBGene00000836", "Q23457", "WBGene00004320", "Q965N7", "WBGene00021596", "Q965N6", "WBGene00021597", "L8E6Y3", "WBGene00016407", "P91133", "WBGene00016326", "Q9BL11", "WBGene00021685", "U4PBY0", "WBGene00022069", "B1Q249", "WBGene00015926", "Q9UAQ3", "WBGene00016539", "A0A061ACQ8", "WBGene00022358", "Q20871", "WBGene00021721", "Q20874", "WBGene00021721", "A8DJA6", "WBGene00021721", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "O62235", "WBGene00009477", "Q965X6", "WBGene00021369", "Q9N3T6", "WBGene00021640", "Q9N4I6", "WBGene00022115", "Q94251", "WBGene00001089", "Q17531", "WBGene00007206", "Q17962", "WBGene00007574", "O17324", "WBGene00015673", "Q20367", "WBGene00005013", "Q9GYI0", "WBGene00017920", "O45323", "WBGene00008439", "P34284", "WBGene00015350", "Q6A590", "WBGene00020884", "G5EES6", "WBGene00007333", "Q9N3G1", "WBGene00021815", "Q22071", "WBGene00003177", "G5ECU1", "WBGene00004807", "Q17389", "WBGene00000836", "Q23457", "WBGene00004320", "Q965N7", "WBGene00021596", "Q965N6", "WBGene00021597", "L8E6Y3", "WBGene00016407", "P91133", "WBGene00016326", "Q9BL11", "WBGene00021685", "U4PBY0", "WBGene00022069", "B1Q249", "WBGene00015926", "Q9UAQ3", "WBGene00016539", "A0A061ACQ8", "WBGene00022358", "Q20871", "WBGene00021721", "Q20874", "WBGene00021721", "A8DJA6", "WBGene00021721" ] }, "reaction_10531314": { "compartment": "compartment_70101", "id": "reaction_10531314", "reactome": "R-CEL-983147", "name": "Release of E3 from polyubiquitinated substrate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10531312" ], "products": [ "species_983123", "species_10531179" ], "modifiers": [], "additional_components": [ "O62235", "WBGene00009477", "Q965X6", "WBGene00021369", "Q9N3T6", "WBGene00021640", "Q9N4I6", "WBGene00022115", "Q94251", "WBGene00001089", "Q17531", "WBGene00007206", "Q17962", "WBGene00007574", "O17324", "WBGene00015673", "Q20367", "WBGene00005013", "Q9GYI0", "WBGene00017920", "O45323", "WBGene00008439", "P34284", "WBGene00015350", "Q6A590", "WBGene00020884", "G5EES6", "WBGene00007333", "Q9N3G1", "WBGene00021815", "Q22071", "WBGene00003177", "G5ECU1", "WBGene00004807", "Q17389", "WBGene00000836", "Q23457", "WBGene00004320", "Q965N7", "WBGene00021596", "Q965N6", "WBGene00021597", "L8E6Y3", "WBGene00016407", "P91133", "WBGene00016326", "Q9BL11", "WBGene00021685", "U4PBY0", "WBGene00022069", "B1Q249", "WBGene00015926", "Q9UAQ3", "WBGene00016539", "A0A061ACQ8", "WBGene00022358", "Q20871", "WBGene00021721", "Q20874", "WBGene00021721", "A8DJA6", "WBGene00021721", "O62235", "WBGene00009477", "Q965X6", "WBGene00021369", "Q9N3T6", "WBGene00021640", "Q9N4I6", "WBGene00022115", "Q94251", "WBGene00001089", "Q17531", "WBGene00007206", "Q17962", "WBGene00007574", "O17324", "WBGene00015673", "Q20367", "WBGene00005013", "Q9GYI0", "WBGene00017920", "O45323", "WBGene00008439", "P34284", "WBGene00015350", "Q6A590", "WBGene00020884", "G5EES6", "WBGene00007333", "Q9N3G1", "WBGene00021815", "Q22071", "WBGene00003177", "G5ECU1", "WBGene00004807", "Q17389", "WBGene00000836", "Q23457", "WBGene00004320", "Q965N7", "WBGene00021596", "Q965N6", "WBGene00021597", "L8E6Y3", "WBGene00016407", "P91133", "WBGene00016326", "Q9BL11", "WBGene00021685", "U4PBY0", "WBGene00022069", "B1Q249", "WBGene00015926", "Q9UAQ3", "WBGene00016539", "A0A061ACQ8", "WBGene00022358", "Q20871", "WBGene00021721", "Q20874", "WBGene00021721", "A8DJA6", "WBGene00021721" ] }, "reaction_10531348": { "compartment": "compartment_70101", "id": "reaction_10531348", "reactome": "R-CEL-983157", "name": "Interaction of E3 with substrate and E2-Ub complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10531247", "species_10531179", "species_983035" ], "products": [ "species_10531249" ], "modifiers": [], "additional_components": [ "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "P52478", "WBGene00006701", "O62235", "WBGene00009477", "Q965X6", "WBGene00021369", "Q9N3T6", "WBGene00021640", "Q9N4I6", "WBGene00022115", "Q94251", "WBGene00001089", "Q17531", "WBGene00007206", "Q17962", "WBGene00007574", "O17324", "WBGene00015673", "Q20367", "WBGene00005013", "Q9GYI0", "WBGene00017920", "O45323", "WBGene00008439", "P34284", "WBGene00015350", "Q6A590", "WBGene00020884", "G5EES6", "WBGene00007333", "Q9N3G1", "WBGene00021815", "Q22071", "WBGene00003177", "G5ECU1", "WBGene00004807", "Q17389", "WBGene00000836", "Q23457", "WBGene00004320", "Q965N7", "WBGene00021596", "Q965N6", "WBGene00021597", "L8E6Y3", "WBGene00016407", "P91133", "WBGene00016326", "Q9BL11", "WBGene00021685", "U4PBY0", "WBGene00022069", "B1Q249", "WBGene00015926", "Q9UAQ3", "WBGene00016539", "A0A061ACQ8", "WBGene00022358", "Q20871", "WBGene00021721", "Q20874", "WBGene00021721", "A8DJA6", "WBGene00021721", "O62235", "WBGene00009477", "Q965X6", "WBGene00021369", "Q9N3T6", "WBGene00021640", "Q9N4I6", "WBGene00022115", "Q94251", "WBGene00001089", "Q17531", "WBGene00007206", "Q17962", "WBGene00007574", "O17324", "WBGene00015673", "Q20367", "WBGene00005013", "Q9GYI0", "WBGene00017920", "O45323", "WBGene00008439", "P34284", "WBGene00015350", "Q6A590", "WBGene00020884", "G5EES6", "WBGene00007333", "Q9N3G1", "WBGene00021815", "Q22071", "WBGene00003177", "G5ECU1", "WBGene00004807", "Q17389", "WBGene00000836", "Q23457", "WBGene00004320", "Q965N7", "WBGene00021596", "Q965N6", "WBGene00021597", "L8E6Y3", "WBGene00016407", "P91133", "WBGene00016326", "Q9BL11", "WBGene00021685", "U4PBY0", "WBGene00022069", "B1Q249", "WBGene00015926", "Q9UAQ3", "WBGene00016539", "A0A061ACQ8", "WBGene00022358", "Q20871", "WBGene00021721", "Q20874", "WBGene00021721", "A8DJA6", "WBGene00021721", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "P52478", "WBGene00006701" ] }, "reaction_10531316": { "compartment": "compartment_70101", "id": "reaction_10531316", "reactome": "R-CEL-983150", "name": "Proteasomal cleavage of substrate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_983123" ], "products": [ "species_10502375", "species_983032", "species_8942986", "species_983036" ], "modifiers": [ [ "species_10502572", "catalyst" ] ], "additional_components": [ "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "P91477", "WBGene00003950", "Q95PZ7", "WBGene00013435", "Q18115", "WBGene00004459", "O62102", "WBGene00003948", "O17071", "WBGene00004504", "Q10920", "WBGene00016623", "P34286", "WBGene00003952", "Q9XTT9", "WBGene00004506", "Q23449", "WBGene00004468", "Q95005", "WBGene00003925", "P46502", "WBGene00004503", "O61792", "WBGene00004464", "O17586", "WBGene00003922", "O76371", "WBGene00004505", "Q20585", "WBGene00004463", "Q95008", "WBGene00003926", "Q18787", "WBGene00004501", "Q20058", "WBGene00009445", "Q9N599", "WBGene00003924", "O16368", "WBGene00004502", "O61742", "WBGene00004466", "Q09583", "WBGene00003928", "Q966I8", "WBGene00003947", "Q04908", "WBGene00004460", "Q9XUV0", "WBGene00003951", "Q27488", "WBGene00003923", "Q9GZH5", "WBGene00004458", "O44156", "WBGene00003927", "Q22253", "WBGene00004465", "O76577", "WBGene00004467", "P90868", "WBGene00003953", "Q19324", "WBGene00004461", "Q17971", "WBGene00007588", "Q23237", "WBGene00003949", "Q20938", "WBGene00004462" ] }, "reaction_10531256": { "compartment": "compartment_70101", "id": "reaction_10531256", "reactome": "R-CEL-983140", "name": "Transfer of Ub from E2 to substrate and release of E2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10531249" ], "products": [ "species_111294", "species_10531245", "species_10531253", "species_76577" ], "modifiers": [ [ "species_10531179", "catalyst" ] ], "additional_components": [ "O62235", "WBGene00009477", "Q965X6", "WBGene00021369", "Q9N3T6", "WBGene00021640", "Q9N4I6", "WBGene00022115", "Q94251", "WBGene00001089", "Q17531", "WBGene00007206", "Q17962", "WBGene00007574", "O17324", "WBGene00015673", "Q20367", "WBGene00005013", "Q9GYI0", "WBGene00017920", "O45323", "WBGene00008439", "P34284", "WBGene00015350", "Q6A590", "WBGene00020884", "G5EES6", "WBGene00007333", "Q9N3G1", "WBGene00021815", "Q22071", "WBGene00003177", "G5ECU1", "WBGene00004807", "Q17389", "WBGene00000836", "Q23457", "WBGene00004320", "Q965N7", "WBGene00021596", "Q965N6", "WBGene00021597", "L8E6Y3", "WBGene00016407", "P91133", "WBGene00016326", "Q9BL11", "WBGene00021685", "U4PBY0", "WBGene00022069", "B1Q249", "WBGene00015926", "Q9UAQ3", "WBGene00016539", "A0A061ACQ8", "WBGene00022358", "Q20871", "WBGene00021721", "Q20874", "WBGene00021721", "A8DJA6", "WBGene00021721", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "P52478", "WBGene00006701", "P52478", "WBGene00006701", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "O62235", "WBGene00009477", "Q965X6", "WBGene00021369", "Q9N3T6", "WBGene00021640", "Q9N4I6", "WBGene00022115", "Q94251", "WBGene00001089", "Q17531", "WBGene00007206", "Q17962", "WBGene00007574", "O17324", "WBGene00015673", "Q20367", "WBGene00005013", "Q9GYI0", "WBGene00017920", "O45323", "WBGene00008439", "P34284", "WBGene00015350", "Q6A590", "WBGene00020884", "G5EES6", "WBGene00007333", "Q9N3G1", "WBGene00021815", "Q22071", "WBGene00003177", "G5ECU1", "WBGene00004807", "Q17389", "WBGene00000836", "Q23457", "WBGene00004320", "Q965N7", "WBGene00021596", "Q965N6", "WBGene00021597", "L8E6Y3", "WBGene00016407", "P91133", "WBGene00016326", "Q9BL11", "WBGene00021685", "U4PBY0", "WBGene00022069", "B1Q249", "WBGene00015926", "Q9UAQ3", "WBGene00016539", "A0A061ACQ8", "WBGene00022358", "Q20871", "WBGene00021721", "Q20874", "WBGene00021721", "A8DJA6", "WBGene00021721", "O62235", "WBGene00009477", "Q965X6", "WBGene00021369", "Q9N3T6", "WBGene00021640", "Q9N4I6", "WBGene00022115", "Q94251", "WBGene00001089", "Q17531", "WBGene00007206", "Q17962", "WBGene00007574", "O17324", "WBGene00015673", "Q20367", "WBGene00005013", "Q9GYI0", "WBGene00017920", "O45323", "WBGene00008439", "P34284", "WBGene00015350", "Q6A590", "WBGene00020884", "G5EES6", "WBGene00007333", "Q9N3G1", "WBGene00021815", "Q22071", "WBGene00003177", "G5ECU1", "WBGene00004807", "Q17389", "WBGene00000836", "Q23457", "WBGene00004320", "Q965N7", "WBGene00021596", "Q965N6", "WBGene00021597", "L8E6Y3", "WBGene00016407", "P91133", "WBGene00016326", "Q9BL11", "WBGene00021685", "U4PBY0", "WBGene00022069", "B1Q249", "WBGene00015926", "Q9UAQ3", "WBGene00016539", "A0A061ACQ8", "WBGene00022358", "Q20871", "WBGene00021721", "Q20874", "WBGene00021721", "A8DJA6", "WBGene00021721" ] }, "reaction_10531340": { "compartment": "compartment_70101", "id": "reaction_10531340", "reactome": "R-CEL-983152", "name": "Transfer of ubiquitin from E1 to E2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10531245", "species_10531337" ], "products": [ "species_10531247", "species_10531335" ], "modifiers": [ [ "species_10531245", "catalyst" ] ], "additional_components": [ "P52478", "WBGene00006701", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "P52478", "WBGene00006701", "P52478", "WBGene00006701" ] }, "reaction_10531343": { "compartment": "compartment_70101", "id": "reaction_10531343", "reactome": "R-CEL-983153", "name": "E1 mediated ubiquitin activation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10531335", "species_10502375", "species_29926" ], "products": [ "species_111294", "species_10531337", "species_29926", "species_76577" ], "modifiers": [ [ "species_10531335", "catalyst" ] ], "additional_components": [ "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727" ] }, "reaction_10531399": { "compartment": "compartment_17957", "id": "reaction_10531399", "reactome": "R-CEL-983158", "name": "Trimming of peptides in ER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_983034" ], "products": [ "species_8943716", "species_983033" ], "modifiers": [ [ "species_10531396", "catalyst" ] ], "additional_components": [ "Q9NAA0", "WBGene00022073", "A5A631", "WBGene00022073", "G5EGH4", "WBGene00022073", "H2L0M5", "WBGene00022073", "Q22317", "WBGene00011587", "Q4TT88", "WBGene00003914" ] }, "reaction_10531304": { "compartment": "compartment_17957", "id": "reaction_10531304", "reactome": "R-CEL-983144", "name": "Transport of Antigen peptide in to ER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_983032" ], "products": [ "species_29372", "species_29370", "species_983034" ], "modifiers": [ [ "species_10531301", "catalyst" ] ], "additional_components": [ "Q9U275", "WBGene00001817", "O02086", "WBGene00001812", "O18227", "WBGene00001818", "O44897", "WBGene00001819", "Q9TZD9", "WBGene00001814" ] }, "reaction_10515960": { "compartment": "compartment_12045", "id": "reaction_10515960", "reactome": "R-CEL-203979", "name": "Coat Assembly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10515678", "species_10515956" ], "products": [ "species_10515958" ], "modifiers": [], "additional_components": [ "Q23445", "WBGene00022678", "species_29438", "Q9U2Z1", "WBGene00004754", "Q19371", "WBGene00004755", "Q23368", "WBGene00004756", "Q23368", "WBGene00004756", "Q19371", "WBGene00004755", "Q9U2Z1", "WBGene00004754", "Q23445", "WBGene00022678", "species_29438" ] }, "reaction_10543540": { "compartment": "compartment_161320", "id": "reaction_10543540", "reactome": "R-CEL-2213240", "name": "Reduction of disulphide bonds in MHC II antigens", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2213221" ], "products": [ "species_2213225" ], "modifiers": [ [ "species_10543537", "catalyst" ] ], "additional_components": [ "WBGene00015336" ] }, "reaction_10542853": { "compartment": "compartment_161320", "id": "reaction_10542853", "reactome": "R-CEL-2130706", "name": "MHC class II antigen processing", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2213225" ], "products": [ "species_2213226" ], "modifiers": [ [ "species_10542850", "catalyst" ] ], "additional_components": [ "Q21966", "WBGene00000217", "Q93512", "WBGene00019986", "O45734", "WBGene00000776", "Q23030", "WBGene00019986", "O16454", "WBGene00007055" ] }, "reaction_10531914": { "compartment": "compartment_70101", "id": "reaction_10531914", "reactome": "R-CEL-1168373", "name": "PRKCB (Protein kinase C beta, PKC-beta) binds diacylglycerol and phosphatidylserine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_33625", "species_114519", "species_10509541", "species_74016" ], "products": [ "species_10509549" ], "modifiers": [], "additional_components": [ "WBGene00004033", "species_114519", "species_33625", "species_74016", "P90980", "WBGene00004033" ] }, "reaction_10531939": { "compartment": "compartment_876", "id": "reaction_10531939", "reactome": "R-CEL-1168636", "name": "p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10512175", "species_29438" ], "products": [ "species_29420", "species_10511481" ], "modifiers": [ [ "species_10531936", "catalyst" ] ], "additional_components": [ "species_29420", "P22981", "WBGene00002335", "species_29438", "P22981", "WBGene00002335", "species_114519", "Q19770", "WBGene00009100" ] }, "reaction_10520805": { "compartment": "compartment_70101", "id": "reaction_10520805", "reactome": "R-CEL-390329", "name": "Dephosphorylation of AKT by PP2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10513848" ], "products": [ "species_29372", "species_10520802" ], "modifiers": [ [ "species_10513555", "catalyst" ] ], "additional_components": [ "Q9XTG7", "WBGene00000103", "G4S4W1", "WBGene00016980", "Q17941", "WBGene00000102", "G4S4W1", "WBGene00016980", "Q17941", "WBGene00000102", "Q9XTG7", "WBGene00000103" ] }, "reaction_10537056": { "compartment": "compartment_876", "id": "reaction_10537056", "reactome": "R-CEL-1675773", "name": "PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_202247" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10537051", "catalyst" ] ], "additional_components": [ "WBGene00004087" ] }, "reaction_10537312": { "compartment": "compartment_876", "id": "reaction_10537312", "reactome": "R-CEL-1676164", "name": "PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_202247" ], "products": [ "species_1806276", "species_29372" ], "modifiers": [ [ "species_10537307", "catalyst" ] ], "additional_components": [ "Q21623", "WBGene00010975" ] }, "reaction_10537153": { "compartment": "compartment_876", "id": "reaction_10537153", "reactome": "R-CEL-1675836", "name": "PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1806224" ], "products": [ "species_1806276", "species_29372" ], "modifiers": [ [ "species_10537150", "catalyst" ] ], "additional_components": [ "O17590", "WBGene00007620", "G5ECL2", "WBGene00006763" ] }, "reaction_10537283": { "compartment": "compartment_876", "id": "reaction_10537283", "reactome": "R-CEL-1676134", "name": "PI3P is phosphorylated to PI(3,5)P2 by PIP5K1A/B at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806276", "species_113592" ], "products": [ "species_1806224", "species_29370" ], "modifiers": [ [ "species_10537051", "catalyst" ] ], "additional_components": [ "WBGene00004087" ] }, "reaction_10537317": { "compartment": "compartment_876", "id": "reaction_10537317", "reactome": "R-CEL-1676177", "name": "PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_179856" ], "products": [ "species_29372", "species_392417" ], "modifiers": [ [ "species_10537314", "catalyst" ] ], "additional_components": [ "G5ECL2", "WBGene00006763", "G5EGN9", "WBGene00012016", "P34370", "WBGene00086546" ] }, "reaction_10537126": { "compartment": "compartment_876", "id": "reaction_10537126", "reactome": "R-CEL-1675810", "name": "PI is phosphorylated to PI5P by PIP5K1A/B at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_426658" ], "products": [ "species_1806240", "species_29370" ], "modifiers": [ [ "species_10537051", "catalyst" ] ], "additional_components": [ "WBGene00004087" ] }, "reaction_10537222": { "compartment": "compartment_876", "id": "reaction_10537222", "reactome": "R-CEL-1675988", "name": "PI4P is dephosphorylated to PI by SYNJ at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_392417" ], "products": [ "species_29372", "species_426658" ], "modifiers": [ [ "species_10537150", "catalyst" ] ], "additional_components": [ "O17590", "WBGene00007620", "G5ECL2", "WBGene00006763" ] }, "reaction_10563656": { "compartment": "compartment_70101", "id": "reaction_10563656", "reactome": "R-CEL-6809309", "name": "MTMR6 binds MTMR9", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10563629", "species_10537228" ], "products": [ "species_10563654" ], "modifiers": [], "additional_components": [ "WBGene00003479", "F53A2.8a", "G5ED68", "F53A2.8a", "Q965W9", "WBGene00003479" ] }, "reaction_10537291": { "compartment": "compartment_876", "id": "reaction_10537291", "reactome": "R-CEL-1676145", "name": "PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806276", "species_113592" ], "products": [ "species_29370", "species_202247" ], "modifiers": [ [ "species_10537288", "catalyst" ] ], "additional_components": [ "Q9BL73", "WBGene00004088", "O01759", "WBGene00004087" ] }, "reaction_10563661": { "compartment": "compartment_876", "id": "reaction_10563661", "reactome": "R-CEL-6809320", "name": "PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1806224" ], "products": [ "species_29372", "species_1806240" ], "modifiers": [ [ "species_10563658", "catalyst" ] ], "additional_components": [ "G5ED68", "F53A2.8a", "Q965W9", "WBGene00003479" ] }, "reaction_10537325": { "compartment": "compartment_876", "id": "reaction_10537325", "reactome": "R-CEL-1676203", "name": "PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1806224" ], "products": [ "species_29372", "species_1806240" ], "modifiers": [ [ "species_10537230", "catalyst" ] ], "additional_components": [ "Q9N589", "WBGene00003475", "Q22712", "WBGene00003476", "G5ECL2", "WBGene00006763", "G5ED68", "F53A2.8a" ] }, "reaction_10537101": { "compartment": "compartment_876", "id": "reaction_10537101", "reactome": "R-CEL-1675780", "name": "PI is phosphorylated to PI4P by PI4K2A/B at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_426658" ], "products": [ "species_29370", "species_392417" ], "modifiers": [ [ "species_10537098", "catalyst" ] ], "additional_components": [ "O45318", "WBGene00022501", "Q23083", "WBGene00022501" ] }, "reaction_10537294": { "compartment": "compartment_876", "id": "reaction_10537294", "reactome": "R-CEL-1676149", "name": "PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_202247" ], "products": [ "species_29372", "species_392417" ], "modifiers": [ [ "species_10514327", "catalyst" ] ], "additional_components": [ "WBGene00000913" ] }, "reaction_10537264": { "compartment": "compartment_876", "id": "reaction_10537264", "reactome": "R-CEL-1676109", "name": "PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_392417" ], "products": [ "species_29370", "species_202247" ], "modifiers": [ [ "species_10537261", "catalyst" ] ], "additional_components": [ "G5EDP9", "WBGene00000001", "Q94125", "WBGene00000090", "G5EDY0", "WBGene00009552", "species_74016", "species_114632", "species_266099" ] }, "reaction_10563633": { "compartment": "compartment_70101", "id": "reaction_10563633", "reactome": "R-CEL-6809254", "name": "MTMR8 binds MTMR9", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10563629", "species_10563624" ], "products": [ "species_10563631" ], "modifiers": [], "additional_components": [ "WBGene00003479", "F53A2.8a", "G5ED68", "F53A2.8a", "Q965W9", "WBGene00003479" ] }, "reaction_10537233": { "compartment": "compartment_876", "id": "reaction_10537233", "reactome": "R-CEL-1675994", "name": "PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806276", "species_29356" ], "products": [ "species_29372", "species_426658" ], "modifiers": [ [ "species_10537230", "catalyst" ] ], "additional_components": [ "Q9N589", "WBGene00003475", "Q22712", "WBGene00003476", "G5ECL2", "WBGene00006763", "G5ED68", "F53A2.8a" ] }, "reaction_10563664": { "compartment": "compartment_876", "id": "reaction_10563664", "reactome": "R-CEL-6809325", "name": "PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806276", "species_29356" ], "products": [ "species_29372", "species_426658" ], "modifiers": [ [ "species_10563658", "catalyst" ] ], "additional_components": [ "G5ED68", "F53A2.8a", "Q965W9", "WBGene00003479" ] }, "reaction_10567095": { "compartment": "compartment_20699", "id": "reaction_10567095", "reactome": "R-CEL-8870499", "name": "PLEKHA3,8 bind PI4P, ARF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806217", "species_10567091", "species_10517985" ], "products": [ "species_10567093" ], "modifiers": [], "additional_components": [ "WBGene00022347", "WBGene00000183", "G5EFK4", "WBGene00000183", "Q9BKS2", "WBGene00022347", "species_1806234" ] }, "reaction_10537244": { "compartment": "compartment_876", "id": "reaction_10537244", "reactome": "R-CEL-1676048", "name": "PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10537241", "catalyst" ] ], "additional_components": [ "G5EDP9", "WBGene00000001", "Q94125", "WBGene00000090" ] }, "reaction_10537215": { "compartment": "compartment_876", "id": "reaction_10537215", "reactome": "R-CEL-1675949", "name": "PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_179838" ], "products": [ "species_29372", "species_202247" ], "modifiers": [ [ "species_10537212", "catalyst" ] ], "additional_components": [ "G5EGN9", "WBGene00012016", "P34370", "WBGene00086546" ] }, "reaction_10509393": { "compartment": "compartment_7660", "id": "reaction_10509393", "reactome": "R-CEL-113407", "name": "DSIF complex binds to RNA Pol II (hypophosphorylated)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509356", "species_10509234" ], "products": [ "species_10509358" ], "modifiers": [], "additional_components": [ "Q9XUM4", "WBGene00012236", "P16356", "WBGene00000123", "Q19826", "WBGene00017830", "Q9XVH6", "WBGene00012187", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q9U3I0", "WBGene00009078", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q10578", "WBGene00016140", "Q17684", "WBGene00007355", "O02092", "WBGene00018391", "Q9GR61", "WBGene00021347", "Q9N3C9", "WBGene00021845", "Q93338", "WBGene00007971", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "Q9TZ93", "WBGene00005014", "Q21338", "WBGene00005015", "Q9TZ93", "WBGene00005014", "Q21338", "WBGene00005015", "Q9XUM4", "WBGene00012236", "P16356", "WBGene00000123", "Q19826", "WBGene00017830", "Q9XVH6", "WBGene00012187", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q9U3I0", "WBGene00009078", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q10578", "WBGene00016140", "Q17684", "WBGene00007355", "O02092", "WBGene00018391", "Q9GR61", "WBGene00021347", "Q9N3C9", "WBGene00021845", "Q93338", "WBGene00007971", "Q93594", "WBGene00009141", "O01763", "WBGene00018156" ] }, "reaction_10509363": { "compartment": "compartment_7660", "id": "reaction_10509363", "reactome": "R-CEL-112383", "name": "Hypophosphorylation of RNA Pol II CTD by FCP1P protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10506316", "species_10504427", "species_10509239" ], "products": [ "species_10506316", "species_10509356" ], "modifiers": [ [ "species_10509239", "catalyst" ] ], "additional_components": [ "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "WBGene00012236", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q9XUM4", "WBGene00012236", "P16356", "WBGene00000123", "Q19826", "WBGene00017830", "Q9XVH6", "WBGene00012187", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q9U3I0", "WBGene00009078", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q10578", "WBGene00016140", "Q17684", "WBGene00007355", "O02092", "WBGene00018391", "Q9GR61", "WBGene00021347", "Q9N3C9", "WBGene00021845", "Q93338", "WBGene00007971", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "WBGene00012236" ] }, "reaction_10509381": { "compartment": "compartment_7660", "id": "reaction_10509381", "reactome": "R-CEL-112396", "name": "Separation of elongating transcript from template", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509377" ], "products": [ "species_10509379" ], "modifiers": [], "additional_components": [ "Q9TXQ9", "WBGene00017011", "Q9TVL3", "WBGene00000410", "P34424", "WBGene00000508", "P34425", "WBGene00000507", "O17869", "WBGene00009650", "Q9N5R9", "WBGene00018849", "P41848", "WBGene00001974", "species_110614", "species_29358", "species_29494", "species_29438", "P34703", "WBGene00001259", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q9N554", "WBGene00021281", "Q9TZ93", "WBGene00005014", "Q21338", "WBGene00005015", "H2KYV0", "WBGene00016115", "P52652", "WBGene00012000", "Q9XUM4", "WBGene00012236", "Q09413", "WBGene00010990", "Q9BKS1", "WBGene00001236", "G5ECR7", "WBGene00001235", "G5EBY0", "WBGene00009103", "Q03560", "WBGene00007184", "A5Z2V7", "WBGene00008533", "Q17431", "WBGene00007110", "P90783", "WBGene00008338", "Q9N5U5", "WBGene00018064", "Q19375", "WBGene00008729", "Q9TXQ9", "WBGene00017011", "Q9TVL3", "WBGene00000410", "P34424", "WBGene00000508", "P34425", "WBGene00000507", "O17869", "WBGene00009650", "Q9N5R9", "WBGene00018849", "P41848", "WBGene00001974", "species_110614", "species_29358", "species_29494", "species_29438", "P34703", "WBGene00001259", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q9N554", "WBGene00021281", "Q9TZ93", "WBGene00005014", "Q21338", "WBGene00005015", "H2KYV0", "WBGene00016115", "P52652", "WBGene00012000", "Q9XUM4", "WBGene00012236", "Q09413", "WBGene00010990", "Q9BKS1", "WBGene00001236", "G5ECR7", "WBGene00001235", "G5EBY0", "WBGene00009103", "Q03560", "WBGene00007184", "A5Z2V7", "WBGene00008533", "Q17431", "WBGene00007110", "P90783", "WBGene00008338", "Q9N5U5", "WBGene00018064", "Q19375", "WBGene00008729" ] }, "reaction_10509367": { "compartment": "compartment_7660", "id": "reaction_10509367", "reactome": "R-CEL-112385", "name": "Addition of nucleotides leads to transcript elongation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509350", "species_30595" ], "products": [ "species_10506316", "species_10509365" ], "modifiers": [], "additional_components": [ "Q9N5R9", "WBGene00018849", "P41848", "WBGene00001974", "P34703", "WBGene00001259", "H2KYV0", "WBGene00016115", "P52652", "WBGene00012000", "Q09413", "WBGene00010990", "Q9BKS1", "WBGene00001236", "G5ECR7", "WBGene00001235", "G5EBY0", "WBGene00009103", "Q03560", "WBGene00007184", "A5Z2V7", "WBGene00008533", "Q17431", "WBGene00007110", "P90783", "WBGene00008338", "Q9N5U5", "WBGene00018064", "Q9TXQ9", "WBGene00017011", "Q9TVL3", "WBGene00000410", "P34424", "WBGene00000508", "P34425", "WBGene00000507", "O17869", "WBGene00009650", "Q9TZ93", "WBGene00005014", "Q21338", "WBGene00005015", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q9XUM4", "WBGene00012236", "Q9N554", "WBGene00021281", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q19375", "WBGene00008729", "species_110614", "species_29358", "species_29494", "species_29438", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q9TXQ9", "WBGene00017011", "Q9TVL3", "WBGene00000410", "P34424", "WBGene00000508", "P34425", "WBGene00000507", "O17869", "WBGene00009650", "Q9N5R9", "WBGene00018849", "P41848", "WBGene00001974", "species_110614", "species_29358", "species_29494", "species_29438", "P34703", "WBGene00001259", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q9N554", "WBGene00021281", "Q9TZ93", "WBGene00005014", "Q21338", "WBGene00005015", "H2KYV0", "WBGene00016115", "P52652", "WBGene00012000", "Q9XUM4", "WBGene00012236", "Q09413", "WBGene00010990", "Q9BKS1", "WBGene00001236", "G5ECR7", "WBGene00001235", "G5EBY0", "WBGene00009103", "Q03560", "WBGene00007184", "A5Z2V7", "WBGene00008533", "Q17431", "WBGene00007110", "P90783", "WBGene00008338", "Q9N5U5", "WBGene00018064", "Q19375", "WBGene00008729" ] }, "reaction_10509399": { "compartment": "compartment_7660", "id": "reaction_10509399", "reactome": "R-CEL-113412", "name": "Pol II elongation complex moves on the template as transcript elongates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509365", "species_30595" ], "products": [ "species_30595", "species_10509377" ], "modifiers": [], "additional_components": [ "Q9TXQ9", "WBGene00017011", "Q9TVL3", "WBGene00000410", "P34424", "WBGene00000508", "P34425", "WBGene00000507", "O17869", "WBGene00009650", "Q9N5R9", "WBGene00018849", "P41848", "WBGene00001974", "species_110614", "species_29358", "species_29494", "species_29438", "P34703", "WBGene00001259", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q9N554", "WBGene00021281", "Q9TZ93", "WBGene00005014", "Q21338", "WBGene00005015", "H2KYV0", "WBGene00016115", "P52652", "WBGene00012000", "Q9XUM4", "WBGene00012236", "Q09413", "WBGene00010990", "Q9BKS1", "WBGene00001236", "G5ECR7", "WBGene00001235", "G5EBY0", "WBGene00009103", "Q03560", "WBGene00007184", "A5Z2V7", "WBGene00008533", "Q17431", "WBGene00007110", "P90783", "WBGene00008338", "Q9N5U5", "WBGene00018064", "Q19375", "WBGene00008729", "species_110614", "species_29358", "species_29494", "species_29438", "species_110614", "species_29358", "species_29494", "species_29438", "Q9TXQ9", "WBGene00017011", "Q9TVL3", "WBGene00000410", "P34424", "WBGene00000508", "P34425", "WBGene00000507", "O17869", "WBGene00009650", "Q9N5R9", "WBGene00018849", "P41848", "WBGene00001974", "species_110614", "species_29358", "species_29494", "species_29438", "P34703", "WBGene00001259", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q9N554", "WBGene00021281", "Q9TZ93", "WBGene00005014", "Q21338", "WBGene00005015", "H2KYV0", "WBGene00016115", "P52652", "WBGene00012000", "Q9XUM4", "WBGene00012236", "Q09413", "WBGene00010990", "Q9BKS1", "WBGene00001236", "G5ECR7", "WBGene00001235", "G5EBY0", "WBGene00009103", "Q03560", "WBGene00007184", "A5Z2V7", "WBGene00008533", "Q17431", "WBGene00007110", "P90783", "WBGene00008338", "Q9N5U5", "WBGene00018064", "Q19375", "WBGene00008729" ] }, "reaction_10509352": { "compartment": "compartment_7660", "id": "reaction_10509352", "reactome": "R-CEL-112379", "name": "Recruitment of elongation factors to form elongation complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509343", "species_10506316", "species_10509259", "species_10509338", "species_10509306", "species_10509271", "species_10509348", "species_10509283" ], "products": [ "species_10509350" ], "modifiers": [], "additional_components": [ "WBGene00008729", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q9TXQ9", "WBGene00017011", "Q9TVL3", "WBGene00000410", "P34424", "WBGene00000508", "P34425", "WBGene00000507", "O17869", "WBGene00009650", "Q9TZ93", "WBGene00005014", "Q21338", "WBGene00005015", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q9XUM4", "WBGene00012236", "Q9N554", "WBGene00021281", "G5EBY0", "WBGene00009103", "Q03560", "WBGene00007184", "A5Z2V7", "WBGene00008533", "Q17431", "WBGene00007110", "P90783", "WBGene00008338", "Q9N5U5", "WBGene00018064", "Q09413", "WBGene00010990", "Q9BKS1", "WBGene00001236", "G5ECR7", "WBGene00001235", "H2KYV0", "WBGene00016115", "P52652", "WBGene00012000", "WBGene00001259", "Q9N5R9", "WBGene00018849", "P41848", "WBGene00001974", "Q9N5R9", "WBGene00018849", "P41848", "WBGene00001974", "P34703", "WBGene00001259", "H2KYV0", "WBGene00016115", "P52652", "WBGene00012000", "Q09413", "WBGene00010990", "Q9BKS1", "WBGene00001236", "G5ECR7", "WBGene00001235", "G5EBY0", "WBGene00009103", "Q03560", "WBGene00007184", "A5Z2V7", "WBGene00008533", "Q17431", "WBGene00007110", "P90783", "WBGene00008338", "Q9N5U5", "WBGene00018064", "Q9TXQ9", "WBGene00017011", "Q9TVL3", "WBGene00000410", "P34424", "WBGene00000508", "P34425", "WBGene00000507", "O17869", "WBGene00009650", "Q9TZ93", "WBGene00005014", "Q21338", "WBGene00005015", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q9XUM4", "WBGene00012236", "Q9N554", "WBGene00021281", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q19375", "WBGene00008729" ] }, "reaction_10510498": { "compartment": "compartment_876", "id": "reaction_10510498", "reactome": "R-CEL-165026", "name": "OCTN2 / SLC22A5 transports CAR from extracellular space to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_164988", "species_74113" ], "products": [ "species_30235", "species_83910" ], "modifiers": [ [ "species_10510495", "catalyst" ] ], "additional_components": [ "G5EEI9", "WBGene00044455", "Q18795", "WBGene00008271", "G5EGL6", "WBGene00044455", "Q23501", "WBGene00003843", "O18247", "WBGene00044455", "Q4PIX1", "WBGene00044455", "P46499", "WBGene00044455", "Q9BKR9", "WBGene00044455", "Q09617", "WBGene00044455", "A0A0K3AWD3", "WBGene00044455", "Q9U539", "WBGene00003842", "Q18613", "WBGene00044455", "A0A238UKL7", "WBGene00044455", "Q9UAW9", "WBGene00044455", "Q18655", "WBGene00044455" ] }, "reaction_10514514": { "compartment": "compartment_70616", "id": "reaction_10514514", "reactome": "R-CEL-200410", "name": "palmitoylcarnitine + CoASH => palmitoyl-CoA + carnitine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_201050" ], "products": [ "species_201023", "species_77281" ], "modifiers": [ [ "species_10514511", "catalyst" ] ], "additional_components": [ "WBGene00011122" ] }, "reaction_10514597": { "compartment": "compartment_17927", "id": "reaction_10514597", "reactome": "R-CEL-200424", "name": "Exchange of palmitoylcarnitine and carnitine across the inner mitochondrial membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_201023", "species_201034" ], "products": [ "species_549207", "species_201050" ], "modifiers": [ [ "species_10514594", "catalyst" ] ], "additional_components": [ "WBGene00000996" ] }, "reaction_10567572": { "compartment": "compartment_70101", "id": "reaction_10567572", "reactome": "R-CEL-8876889", "name": "Btn-ACACB:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111627", "species_113592", "species_76183" ], "products": [ "species_29372", "species_29370", "species_29508" ], "modifiers": [ [ "species_10514577", "catalyst" ], [ "species_76190", "catalyst" ] ], "additional_components": [ "species_266099", "H2L0M0", "WBGene00004076" ] }, "reaction_10507418": { "compartment": "compartment_70101", "id": "reaction_10507418", "reactome": "R-CEL-75851", "name": "Btn-ACACA:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111627", "species_113592", "species_76183" ], "products": [ "species_29372", "species_29370", "species_29508" ], "modifiers": [ [ "species_10507415", "catalyst" ], [ "species_76190", "catalyst" ] ], "additional_components": [ "Q9XUC3", "WBGene00012131", "H2L0M0", "WBGene00004076", "species_266099" ] }, "reaction_10514589": { "compartment": "compartment_70101", "id": "reaction_10514589", "reactome": "R-CEL-200423", "name": "pAMPK inactivates ACACB, inhibiting malonyl-CoA synthesis", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10514577" ], "products": [ "species_29370", "species_10514584" ], "modifiers": [ [ "species_10514586", "catalyst" ] ], "additional_components": [ "species_266099", "H2L0M0", "WBGene00004076", "H2L0M0", "WBGene00004076", "species_266099", "Q9XUY2", "WBGene00010115", "A0A1T5HUK9", "WBGene00013732", "H2L0K0", "WBGene00020135", "O02168", "WBGene00020633", "Q9N501", "WBGene00021527", "Q95ZQ4", "WBGene00020142" ] }, "reaction_10554146": { "compartment": "compartment_13949", "id": "reaction_10554146", "reactome": "R-CEL-5638014", "name": "RAB11A:GTP-containing Golgi vesicles recruit RAB3IP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10554142", "species_10552808" ], "products": [ "species_10554144" ], "modifiers": [], "additional_components": [ "O01803", "WBGene00004274", "species_29438", "WBGene00010045", "Q20759", "WBGene00010045", "O01803", "WBGene00004274", "species_29438" ] }, "reaction_10517298": { "compartment": "compartment_984", "id": "reaction_10517298", "reactome": "R-CEL-216045", "name": "Collagen type I binds integrin alpha11beta1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10517294", "species_10509625", "species_114632" ], "products": [ "species_10517296" ], "modifiers": [], "additional_components": [ "Q27874", "WBGene00003930", "P34446", "WBGene00003929", "Q9N4U2", "WBGene00000647", "species_114632", "Q9N4U2", "WBGene00000647", "Q27874", "WBGene00003930", "P34446", "WBGene00003929" ] }, "reaction_10549011": { "compartment": "compartment_984", "id": "reaction_10549011", "reactome": "R-CEL-4088264", "name": "Endostatin binds integrin alphaVbeta3, alphaVbeta5, alpha3beta1, alpha5beta1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10549007", "species_10543255" ], "products": [ "species_10549009" ], "modifiers": [], "additional_components": [ "P34446", "WBGene00003929", "Q27874", "WBGene00003930", "Q03600", "WBGene00002081", "WBGene00000702", "Q19368", "WBGene00000702", "P34446", "WBGene00003929", "Q27874", "WBGene00003930", "Q03600", "WBGene00002081" ] }, "reaction_10517427": { "compartment": "compartment_984", "id": "reaction_10517427", "reactome": "R-CEL-216068", "name": "Interaction of integrin alpha9beta1 with Tenascin-C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10517423", "species_10517415" ], "products": [ "species_10517425" ], "modifiers": [], "additional_components": [ "Q27874", "WBGene00003930", "P34446", "WBGene00003929", "Q18096", "WBGene00007687", "Q18096", "WBGene00007687", "Q27874", "WBGene00003930", "P34446", "WBGene00003929" ] }, "reaction_10517398": { "compartment": "compartment_984", "id": "reaction_10517398", "reactome": "R-CEL-216050", "name": "Integrins alpha4beta1, alpha8beta1, alphaVbeta1, alphaVbeta3, alphaVbeta6 bind Fibronectin matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10517394", "species_10517392" ], "products": [ "species_10517396" ], "modifiers": [], "additional_components": [ "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769", "Q27874", "WBGene00003930", "P34446", "WBGene00003929", "Q27874", "WBGene00003930", "P34446", "WBGene00003929", "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769" ] }, "reaction_10544599": { "compartment": "compartment_876", "id": "reaction_10544599", "reactome": "R-CEL-2484965", "name": "Collagen type XIII binds Integrin alpha1beta1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10542932", "species_10543907" ], "products": [ "species_10544597" ], "modifiers": [], "additional_components": [ "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689", "Q27874", "WBGene00003930", "P34446", "WBGene00003929", "Q27874", "WBGene00003930", "P34446", "WBGene00003929", "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689" ] }, "reaction_10517290": { "compartment": "compartment_984", "id": "reaction_10517290", "reactome": "R-CEL-216043", "name": "Collagen type II binds integrin alpha10beta1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_114632", "species_10517286", "species_10517168" ], "products": [ "species_10517288" ], "modifiers": [], "additional_components": [ "O76368", "WBGene00000674", "Q09457", "WBGene00000251", "Q9N4U2", "WBGene00000647", "Q27874", "WBGene00003930", "P34446", "WBGene00003929", "Q27874", "WBGene00003930", "P34446", "WBGene00003929", "O76368", "WBGene00000674", "Q09457", "WBGene00000251", "Q9N4U2", "WBGene00000647", "species_114632" ] }, "reaction_10543915": { "compartment": "compartment_876", "id": "reaction_10543915", "reactome": "R-CEL-2327695", "name": "Collagen types III, IV, V, VI, VIII, IX, XVI bind integrins alpha1beta1 and alpha2beta1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10543911", "species_10543909" ], "products": [ "species_10543913" ], "modifiers": [], "additional_components": [ "Q9N4U2", "WBGene00000647", "O76368", "WBGene00000674", "Q09457", "WBGene00000251", "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689", "P17140", "WBGene00002280", "Q27874", "WBGene00003930", "P34446", "WBGene00003929", "Q27874", "WBGene00003930", "P34446", "WBGene00003929", "Q9N4U2", "WBGene00000647", "O76368", "WBGene00000674", "Q09457", "WBGene00000251", "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689", "P17140", "WBGene00002280" ] }, "reaction_10517419": { "compartment": "compartment_984", "id": "reaction_10517419", "reactome": "R-CEL-216064", "name": "Interaction of integrin alpha8beta1 with Tenascin-C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10517386", "species_10517415" ], "products": [ "species_10517417" ], "modifiers": [], "additional_components": [ "Q27874", "WBGene00003930", "P34446", "WBGene00003929", "Q18096", "WBGene00007687", "Q18096", "WBGene00007687", "Q27874", "WBGene00003930", "P34446", "WBGene00003929" ] }, "reaction_10503155": { "compartment": "compartment_70101", "id": "reaction_10503155", "reactome": "R-CEL-70523", "name": "PXLP-K314-GPT transaminates L-Ala to form PYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29406", "species_29432" ], "products": [ "species_29404", "species_29398" ], "modifiers": [ [ "species_10503152", "catalyst" ] ], "additional_components": [ "O01685", "WBGene00016333" ] }, "reaction_10527117": { "compartment": "compartment_5460", "id": "reaction_10527117", "reactome": "R-CEL-507749", "name": "PXLP-K341-GPT2 transaminates PYR to form L-Ala", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113557", "species_113552" ], "products": [ "species_113594", "species_379697" ], "modifiers": [ [ "species_10527114", "catalyst" ] ], "additional_components": [ "O01685", "WBGene00016333" ] }, "reaction_10522765": { "compartment": "compartment_70101", "id": "reaction_10522765", "reactome": "R-CEL-426520", "name": "Endonucleolytic RISC hydrolyzes target RNAs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426523" ], "products": [ "species_426511" ], "modifiers": [ [ "species_10522752", "catalyst" ] ], "additional_components": [ "G5EES3", "WBGene00000105" ] }, "reaction_10571586": { "compartment": "compartment_70101", "id": "reaction_10571586", "reactome": "R-CEL-9029987", "name": "p-S216-CDC25C translocates to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10507015" ], "products": [ "species_10507019" ], "modifiers": [], "additional_components": [ "WBGene00000389", "WBGene00000389" ] }, "reaction_10507368": { "compartment": "compartment_7660", "id": "reaction_10507368", "reactome": "R-CEL-75809", "name": "Phosphorylation of Cdc25C at Ser216 by CHEK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10507012" ], "products": [ "species_113582", "species_10507015" ], "modifiers": [ [ "species_10502800", "catalyst" ] ], "additional_components": [ "WBGene00000389", "WBGene00000389", "WBGene00000499" ] }, "reaction_10572187": { "compartment": "compartment_7660", "id": "reaction_10572187", "reactome": "R-CEL-9617067", "name": "All-trans retinoic acid binds RARA:RXRA at the promoter of the CEBPE gene", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5334804", "species_10572179" ], "products": [ "species_10572185" ], "modifiers": [], "additional_components": [ "Q9XUK7", "WBGene00003675", "P41830", "WBGene00004786", "Q10902", "WBGene00003601", "Q20765", "WBGene00003606", "Q9U2R6", "WBGene00003681", "Q9XUK7", "WBGene00003675", "P41830", "WBGene00004786", "Q10902", "WBGene00003601", "Q20765", "WBGene00003606", "species_5334816", "Q9U2R6", "WBGene00003681" ] }, "reaction_10520037": { "compartment": "compartment_7660", "id": "reaction_10520037", "reactome": "R-CEL-381262", "name": "Formation of PPARG:RXRA heterodimer (ARF6 complex)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10514477", "species_10519413" ], "products": [ "species_10520035" ], "modifiers": [], "additional_components": [ "WBGene00003681", "Q20765", "WBGene00003606", "Q9XUK7", "WBGene00003675", "P41830", "WBGene00004786", "Q10902", "WBGene00003601", "Q20765", "WBGene00003606", "Q9XUK7", "WBGene00003675", "P41830", "WBGene00004786", "Q10902", "WBGene00003601", "Q9U2R6", "WBGene00003681" ] }, "reaction_10535206": { "compartment": "compartment_7660", "id": "reaction_10535206", "reactome": "R-CEL-1535903", "name": "Phospho R-SMAD(SMAD2/3):CO-SMAD(SMAD4):FOXO3 binds FoxO3a-binding elements", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10511518", "species_1535904", "species_10514276" ], "products": [ "species_10535204" ], "modifiers": [], "additional_components": [ "P45897", "WBGene00004858", "Q21733", "WBGene00000904", "WBGene00000912", "O16850", "WBGene00000912", "P45897", "WBGene00004858", "Q21733", "WBGene00000904" ] }, "reaction_10525296": { "compartment": "compartment_7660", "id": "reaction_10525296", "reactome": "R-CEL-448955", "name": "Phosphorylation of MEF2 proteins by p38", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10525266", "species_10525280" ], "products": [ "species_113582", "species_10525293" ], "modifiers": [ [ "species_10525280", "catalyst" ] ], "additional_components": [ "WBGene00003182", "Q17446", "WBGene00004055", "Q8MXI4", "WBGene00004056", "Q17446", "WBGene00004055", "Q8MXI4", "WBGene00004056", "Q9U325", "WBGene00003182", "Q17446", "WBGene00004055", "Q8MXI4", "WBGene00004056" ] }, "reaction_10525370": { "compartment": "compartment_7660", "id": "reaction_10525370", "reactome": "R-CEL-448963", "name": "Interaction of MyoD:E protein with MEF2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10525291", "species_10525366" ], "products": [ "species_10525368" ], "modifiers": [], "additional_components": [ "Q9U325", "WBGene00003182", "P22980", "WBGene00001948", "G5EEG9", "WBGene00001949", "P22980", "WBGene00001948", "G5EEG9", "WBGene00001949", "Q9U325", "WBGene00003182" ] }, "reaction_10518843": { "compartment": "compartment_876", "id": "reaction_10518843", "reactome": "R-CEL-375138", "name": "CDO binds BOC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10518839", "species_10518837" ], "products": [ "species_10518841" ], "modifiers": [], "additional_components": [ "WBGene00004732", "WBGene00004732", "Q53U87", "WBGene00004732" ] }, "reaction_10525341": { "compartment": "compartment_876", "id": "reaction_10525341", "reactome": "R-CEL-448958", "name": "Nuclear translocation of p38 MAPK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10525339" ], "products": [ "species_10525337", "species_10525280" ], "modifiers": [], "additional_components": [ "P34609", "WBGene00006755", "Q53U87", "WBGene00004732", "O44326", "WBGene00001979", "P90947", "WBGene00001978", "Q05062", "WBGene00000390", "species_29438", "P03949", "WBGene00000018", "Q17446", "WBGene00004055", "Q8MXI4", "WBGene00004056", "P34609", "WBGene00006755", "Q53U87", "WBGene00004732", "O44326", "WBGene00001979", "P90947", "WBGene00001978", "Q05062", "WBGene00000390", "species_29438", "P03949", "WBGene00000018", "Q17446", "WBGene00004055", "Q8MXI4", "WBGene00004056" ] }, "reaction_10544128": { "compartment": "compartment_876", "id": "reaction_10544128", "reactome": "R-CEL-2396029", "name": "Latent TGF-beta-3 binds integrins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10517390", "species_10544124" ], "products": [ "species_10544126" ], "modifiers": [], "additional_components": [ "Q27874", "WBGene00003930", "P34446", "WBGene00003929", "G5EEL5", "WBGene00000936", "G5EBY8", "WBGene00006852", "G5EEL5", "WBGene00000936", "G5EBY8", "WBGene00006852", "Q27874", "WBGene00003930", "P34446", "WBGene00003929" ] }, "reaction_10544040": { "compartment": "compartment_876", "id": "reaction_10544040", "reactome": "R-CEL-2395320", "name": "Latent TGF-beta-1 binds integrins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10544036", "species_10544034" ], "products": [ "species_10544038" ], "modifiers": [], "additional_components": [ "Q27874", "WBGene00003930", "P34446", "WBGene00003929", "G5EBY8", "WBGene00006852", "G5EEL5", "WBGene00000936", "G5EBY8", "WBGene00006852", "G5EEL5", "WBGene00000936", "Q27874", "WBGene00003930", "P34446", "WBGene00003929" ] }, "reaction_10544857": { "compartment": "compartment_984", "id": "reaction_10544857", "reactome": "R-CEL-2537665", "name": "Fibulin-1 and -2 bind fibronectin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10517394", "species_10535682" ], "products": [ "species_10544855" ], "modifiers": [], "additional_components": [ "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769", "WBGene00007170", "Q17494", "WBGene00007170", "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769" ] }, "reaction_10530641": { "compartment": "compartment_70101", "id": "reaction_10530641", "reactome": "R-CEL-977333", "name": "PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_977329", "species_29404" ], "products": [ "species_29406", "species_936706" ], "modifiers": [ [ "species_10530638", "catalyst" ] ], "additional_components": [ "P91856", "WBGene00009177" ] }, "reaction_10530630": { "compartment": "compartment_70101", "id": "reaction_10530630", "reactome": "R-CEL-977324", "name": "PSPH:Mg2+ dimer dephosphorylates O-P-Ser", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_936706" ], "products": [ "species_29372", "species_200736" ], "modifiers": [ [ "species_10530627", "catalyst" ] ], "additional_components": [ "A0A061ACK7", "WBGene00013379", "species_114632" ] }, "reaction_10568102": { "compartment": "compartment_70101", "id": "reaction_10568102", "reactome": "R-CEL-8932980", "name": "SERINC3,5,(1,2,4) transport L-Ser from cytosol to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200736" ], "products": [ "species_8932979" ], "modifiers": [ [ "species_10568099", "catalyst" ] ], "additional_components": [ "Q95XV3", "WBGene00021956", "O45719", "WBGene00021956" ] }, "reaction_10571288": { "compartment": "compartment_70101", "id": "reaction_10571288", "reactome": "R-CEL-9014741", "name": "PXLP-K56-SRR dimer deaminates D-Ser", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_376186" ], "products": [ "species_29356", "species_29382", "species_29398" ], "modifiers": [ [ "species_10571285", "catalyst" ], [ "species_29926", "catalyst" ], [ "species_113592", "catalyst" ] ], "additional_components": [ "Q93968", "WBGene00011353" ] }, "reaction_10571291": { "compartment": "compartment_70101", "id": "reaction_10571291", "reactome": "R-CEL-9014766", "name": "PXLP-K56-SRR dimer isomerises L-Ser to D-Ser", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200736" ], "products": [ "species_376186" ], "modifiers": [ [ "species_10571285", "catalyst" ], [ "species_29926", "catalyst" ], [ "species_113592", "catalyst" ] ], "additional_components": [ "Q93968", "WBGene00011353" ] }, "reaction_10530651": { "compartment": "compartment_70101", "id": "reaction_10530651", "reactome": "R-CEL-977348", "name": "PHGHD tetramer dehydrogenates 3PG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29360", "species_29728" ], "products": [ "species_977329", "species_70106", "species_73473" ], "modifiers": [ [ "species_10530648", "catalyst" ] ], "additional_components": [ "O17626", "WBGene00007836" ] }, "reaction_10571806": { "compartment": "compartment_70101", "id": "reaction_10571806", "reactome": "R-CEL-9034539", "name": "PXLP-K56-SRR dimer deaminates L-Ser", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200736" ], "products": [ "species_29356", "species_29382", "species_29398" ], "modifiers": [ [ "species_10571285", "catalyst" ] ], "additional_components": [ "Q93968", "WBGene00011353" ] }, "reaction_10542969": { "compartment": "compartment_70101", "id": "reaction_10542969", "reactome": "R-CEL-2161195", "name": "abacavir monophosphate + H2O => carbovir monophosphate + cyclopropylamine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_2161194" ], "products": [ "species_2161176", "species_2161175" ], "modifiers": [ [ "species_10542964", "catalyst" ] ], "additional_components": [ "Q8IG39", "WBGene00016632", "species_216785" ] }, "reaction_10543017": { "compartment": "compartment_70101", "id": "reaction_10543017", "reactome": "R-CEL-2162066", "name": "carbovir + IMP => carbovir monophosphate + inosine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2161514", "species_29602" ], "products": [ "species_2161176", "species_83927" ], "modifiers": [ [ "species_10506658", "catalyst" ] ], "additional_components": [ "Q95X21", "WBGene00022201", "species_114632" ] }, "reaction_10543020": { "compartment": "compartment_70101", "id": "reaction_10543020", "reactome": "R-CEL-2162078", "name": "abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2161185", "species_29360" ], "products": [ "species_70106", "species_2162081", "species_73473" ], "modifiers": [ [ "species_10504238", "catalyst" ] ], "additional_components": [ "species_216785", "Q17335", "WBGene00019240" ] }, "reaction_10552511": { "compartment": "compartment_7660", "id": "reaction_10552511", "reactome": "R-CEL-5578742", "name": "AGO1,2:small RNA complexes interact with chromatin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10504431", "species_10552507", "species_10517072" ], "products": [ "species_10552509" ], "modifiers": [], "additional_components": [ "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "G5EES3", "WBGene00000105", "O16720", "WBGene00000106", "O61931", "WBGene00019971", "O62275", "WBGene00010263", "P34681", "WBGene00006449", "Q09249", "WBGene00007624", "Q21691", "WBGene00019862", "Q21770", "WBGene00011061", "Q86NJ8", "WBGene00004093", "Q9N585", "WBGene00004094", "A0A0T7CIX3", "WBGene00019666", "Q9TXN7", "WBGene00020707", "A0A0U1RML5", "WBGene00018921", "Q9XVI3", "WBGene00011945", "D9N120", "WBGene00022877", "G5ED77", "WBGene00011910", "G5EEH0", "WBGene00004323", "H2KZD5", "WBGene00017641", "P62784", "WBGene00001875", "K7ZUH9", "WBGene00001914", "Q10453", "WBGene00001945", "P62784", "WBGene00001875", "K7ZUH9", "WBGene00001914", "Q10453", "WBGene00001945", "G5EES3", "WBGene00000105", "O16720", "WBGene00000106", "O61931", "WBGene00019971", "O62275", "WBGene00010263", "P34681", "WBGene00006449", "Q09249", "WBGene00007624", "Q21691", "WBGene00019862", "Q21770", "WBGene00011061", "Q86NJ8", "WBGene00004093", "Q9N585", "WBGene00004094", "A0A0T7CIX3", "WBGene00019666", "Q9TXN7", "WBGene00020707", "A0A0U1RML5", "WBGene00018921", "Q9XVI3", "WBGene00011945", "D9N120", "WBGene00022877", "G5ED77", "WBGene00011910", "G5EEH0", "WBGene00004323", "H2KZD5", "WBGene00017641", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140" ] }, "reaction_10571531": { "compartment": "compartment_70101", "id": "reaction_10571531", "reactome": "R-CEL-9023912", "name": "AGO2 cleaves passenger strand of duplex siRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10542709" ], "products": [ "species_10571528" ], "modifiers": [ [ "species_10542709", "catalyst" ] ], "additional_components": [ "G5EES3", "WBGene00000105", "G5EES3", "WBGene00000105", "G5EES3", "WBGene00000105" ] }, "reaction_10522748": { "compartment": "compartment_70101", "id": "reaction_10522748", "reactome": "R-CEL-426464", "name": "Dicer cleaves double-stranded RNA to yield double-stranded siRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426463", "species_10515589" ], "products": [ "species_10522745" ], "modifiers": [ [ "species_10515589", "catalyst" ] ], "additional_components": [ "G5EBF5", "WBGene00004326", "P34529", "WBGene00000939", "G5EES3", "WBGene00000105", "P34529", "WBGene00000939", "G5EBF5", "WBGene00004326", "G5EES3", "WBGene00000105", "G5EBF5", "WBGene00004326", "P34529", "WBGene00000939", "G5EES3", "WBGene00000105" ] }, "reaction_10542733": { "compartment": "compartment_70101", "id": "reaction_10542733", "reactome": "R-CEL-2106615", "name": "Removal of siRNA passenger strand", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10542723" ], "products": [ "species_10542731" ], "modifiers": [], "additional_components": [ "G5EBF5", "WBGene00004326", "P34529", "WBGene00000939", "G5EES3", "WBGene00000105", "P34529", "WBGene00000939", "G5EES3", "WBGene00000105", "G5EBF5", "WBGene00004326" ] }, "reaction_10542735": { "compartment": "compartment_70101", "id": "reaction_10542735", "reactome": "R-CEL-2106625", "name": "Duplex siRNA is loaded into Argonaute", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10522745" ], "products": [ "species_10542723" ], "modifiers": [], "additional_components": [ "P34529", "WBGene00000939", "G5EBF5", "WBGene00004326", "G5EES3", "WBGene00000105", "G5EBF5", "WBGene00004326", "P34529", "WBGene00000939", "G5EES3", "WBGene00000105" ] }, "reaction_10536517": { "compartment": "compartment_70101", "id": "reaction_10536517", "reactome": "R-CEL-1614583", "name": "PXLP-K212-CTH cleaves L-Cystathionine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1614518", "species_29356" ], "products": [ "species_111707", "species_29382", "species_936714" ], "modifiers": [ [ "species_10536511", "catalyst" ] ], "additional_components": [ "P55216", "WBGene00022856" ] }, "reaction_10536491": { "compartment": "compartment_70101", "id": "reaction_10536491", "reactome": "R-CEL-1614524", "name": "PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200736", "species_174369" ], "products": [ "species_1614518", "species_29356" ], "modifiers": [ [ "species_10536488", "catalyst" ] ], "additional_components": [ "G5EFH8", "WBGene00013866", "species_71185" ] }, "reaction_10537680": { "compartment": "compartment_7660", "id": "reaction_10537680", "reactome": "R-CEL-1855206", "name": "I(1,3,4,5)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_2023891" ], "products": [ "species_113582", "species_2023901" ], "modifiers": [ [ "species_10537657", "catalyst" ] ], "additional_components": [ "WBGene00014081" ] }, "reaction_10537761": { "compartment": "compartment_7660", "id": "reaction_10537761", "reactome": "R-CEL-1855224", "name": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/2 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_2023940" ], "products": [ "species_113582", "species_2023941" ], "modifiers": [ [ "species_10537560", "catalyst" ] ], "additional_components": [ "O02167", "WBGene00021260", "Q93644", "WBGene00021260", "Q9BKX8", "WBGene00021260" ] }, "reaction_10537683": { "compartment": "compartment_7660", "id": "reaction_10537683", "reactome": "R-CEL-1855207", "name": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/2 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_2023929" ], "products": [ "species_113582", "species_2023940" ], "modifiers": [ [ "species_10537560", "catalyst" ] ], "additional_components": [ "O02167", "WBGene00021260", "Q93644", "WBGene00021260", "Q9BKX8", "WBGene00021260" ] }, "reaction_10537767": { "compartment": "compartment_7660", "id": "reaction_10537767", "reactome": "R-CEL-1855228", "name": "I(1,3,4,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_2023892" ], "products": [ "species_113582", "species_2023901" ], "modifiers": [ [ "species_10537657", "catalyst" ] ], "additional_components": [ "WBGene00014081" ] }, "reaction_10537640": { "compartment": "compartment_7660", "id": "reaction_10537640", "reactome": "R-CEL-1855181", "name": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_2023901" ], "products": [ "species_113582", "species_2023922" ], "modifiers": [ [ "species_10537560", "catalyst" ] ], "additional_components": [ "O02167", "WBGene00021260", "Q93644", "WBGene00021260", "Q9BKX8", "WBGene00021260" ] }, "reaction_10537770": { "compartment": "compartment_7660", "id": "reaction_10537770", "reactome": "R-CEL-1855230", "name": "5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_2023922" ], "products": [ "species_113582", "species_2023948" ], "modifiers": [ [ "species_10537560", "catalyst" ] ], "additional_components": [ "O02167", "WBGene00021260", "Q93644", "WBGene00021260", "Q9BKX8", "WBGene00021260" ] }, "reaction_10537563": { "compartment": "compartment_7660", "id": "reaction_10537563", "reactome": "R-CEL-1855157", "name": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_2023932" ], "products": [ "species_113582", "species_2023931" ], "modifiers": [ [ "species_10537560", "catalyst" ] ], "additional_components": [ "O02167", "WBGene00021260", "Q93644", "WBGene00021260", "Q9BKX8", "WBGene00021260" ] }, "reaction_10537660": { "compartment": "compartment_7660", "id": "reaction_10537660", "reactome": "R-CEL-1855185", "name": "I(1,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_2023935" ], "products": [ "species_113582", "species_2023901" ], "modifiers": [ [ "species_10537657", "catalyst" ] ], "additional_components": [ "WBGene00014081" ] }, "reaction_10537773": { "compartment": "compartment_7660", "id": "reaction_10537773", "reactome": "R-CEL-1855233", "name": "I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by IPMK in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_2023907" ], "products": [ "species_113582", "species_2023891" ], "modifiers": [ [ "species_10537657", "catalyst" ] ], "additional_components": [ "WBGene00014081" ] }, "reaction_10537614": { "compartment": "compartment_7660", "id": "reaction_10537614", "reactome": "R-CEL-1855176", "name": "I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK (IP5-2K) in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_2023901" ], "products": [ "species_113582", "species_2023929" ], "modifiers": [ [ "species_10537611", "catalyst" ] ], "additional_components": [ "WBGene00012466" ] }, "reaction_10509797": { "compartment": "compartment_17951", "id": "reaction_10509797", "reactome": "R-CEL-141348", "name": "PAO:FAD oxidises NASPM to PTCN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113535", "species_141343", "species_141349" ], "products": [ "species_141327", "species_113575", "species_141350" ], "modifiers": [ [ "species_10509794", "catalyst" ] ], "additional_components": [ "O76383", "WBGene00016061", "species_113596" ] }, "reaction_10518005": { "compartment": "compartment_70101", "id": "reaction_10518005", "reactome": "R-CEL-351207", "name": "Spermine => N-acetylated spermine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_353560", "species_76183" ], "products": [ "species_76194", "species_353575" ], "modifiers": [ [ "species_10518002", "catalyst" ] ], "additional_components": [ "WBGene00008408" ] }, "reaction_10518007": { "compartment": "compartment_70101", "id": "reaction_10518007", "reactome": "R-CEL-351208", "name": "Spermidine => N-acetylated spermidine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_204635", "species_76183" ], "products": [ "species_353555", "species_76194" ], "modifiers": [ [ "species_10518002", "catalyst" ] ], "additional_components": [ "WBGene00008408" ] }, "reaction_10509799": { "compartment": "compartment_17951", "id": "reaction_10509799", "reactome": "R-CEL-141351", "name": "PAOX:FAD oxidises NASPN to SPM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113535", "species_141343", "species_141323" ], "products": [ "species_141324", "species_141327", "species_113575" ], "modifiers": [ [ "species_10509794", "catalyst" ] ], "additional_components": [ "O76383", "WBGene00016061", "species_113596" ] }, "reaction_10518160": { "compartment": "compartment_70101", "id": "reaction_10518160", "reactome": "R-CEL-353125", "name": "26S proteosome degrades ODC holoenzyme complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10517946" ], "products": [ "species_10517940" ], "modifiers": [ [ "species_10502572", "catalyst" ] ], "additional_components": [ "Q9NHZ6", "WBGene00022748", "P41931", "WBGene00003844", "O01579", "WBGene00018764", "WBGene00022748", "P91477", "WBGene00003950", "Q95PZ7", "WBGene00013435", "Q18115", "WBGene00004459", "O62102", "WBGene00003948", "O17071", "WBGene00004504", "Q10920", "WBGene00016623", "P34286", "WBGene00003952", "Q9XTT9", "WBGene00004506", "Q23449", "WBGene00004468", "Q95005", "WBGene00003925", "P46502", "WBGene00004503", "O61792", "WBGene00004464", "O17586", "WBGene00003922", "O76371", "WBGene00004505", "Q20585", "WBGene00004463", "Q95008", "WBGene00003926", "Q18787", "WBGene00004501", "Q20058", "WBGene00009445", "Q9N599", "WBGene00003924", "O16368", "WBGene00004502", "O61742", "WBGene00004466", "Q09583", "WBGene00003928", "Q966I8", "WBGene00003947", "Q04908", "WBGene00004460", "Q9XUV0", "WBGene00003951", "Q27488", "WBGene00003923", "Q9GZH5", "WBGene00004458", "O44156", "WBGene00003927", "Q22253", "WBGene00004465", "O76577", "WBGene00004467", "P90868", "WBGene00003953", "Q19324", "WBGene00004461", "Q17971", "WBGene00007588", "Q23237", "WBGene00003949", "Q20938", "WBGene00004462" ] }, "reaction_10517948": { "compartment": "compartment_70101", "id": "reaction_10517948", "reactome": "R-CEL-350567", "name": "Antizyme OAZ binds to Ornithine decarboxylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10503318", "species_10517940" ], "products": [ "species_10517946" ], "modifiers": [], "additional_components": [ "P41931", "WBGene00003844", "O01579", "WBGene00018764", "WBGene00022748", "Q9NHZ6", "WBGene00022748", "P41931", "WBGene00003844", "O01579", "WBGene00018764" ] }, "reaction_10517965": { "compartment": "compartment_70101", "id": "reaction_10517965", "reactome": "R-CEL-350600", "name": "Antizyme inhibitor binds to OAZ and stablizes ODC complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10517946", "species_10517959" ], "products": [ "species_10517963" ], "modifiers": [], "additional_components": [ "Q9NHZ6", "WBGene00022748", "P41931", "WBGene00003844", "O01579", "WBGene00018764", "O01579", "WBGene00018764", "P41931", "WBGene00003844", "P41931", "WBGene00003844", "O01579", "WBGene00018764", "Q9NHZ6", "WBGene00022748" ] }, "reaction_10517953": { "compartment": "compartment_70101", "id": "reaction_10517953", "reactome": "R-CEL-350598", "name": "Arginine<=>Agmatine+CO2", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29468" ], "products": [ "species_113528", "species_351164" ], "modifiers": [ [ "species_10517950", "catalyst" ] ], "additional_components": [ "WBGene00003844" ] }, "reaction_10518023": { "compartment": "compartment_70101", "id": "reaction_10518023", "reactome": "R-CEL-351222", "name": "S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71284" ], "products": [ "species_353113", "species_113528" ], "modifiers": [ [ "species_10518020", "catalyst" ] ], "additional_components": [ "WBGene00004875" ] }, "reaction_10503321": { "compartment": "compartment_70101", "id": "reaction_10503321", "reactome": "R-CEL-70692", "name": "ornithine => putrescine + CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29498" ], "products": [ "species_29610", "species_113528" ], "modifiers": [ [ "species_10503318", "catalyst" ] ], "additional_components": [ "P41931", "WBGene00003844", "O01579", "WBGene00018764" ] }, "reaction_10518015": { "compartment": "compartment_70101", "id": "reaction_10518015", "reactome": "R-CEL-351215", "name": "Putrescine + dc-Adenosyl methionine => Spermidine + 5'-methylthioadenosine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_353113", "species_29610" ], "products": [ "species_204635", "species_353106" ], "modifiers": [ [ "species_10518012", "catalyst" ] ], "additional_components": [ "WBGene00012909" ] }, "reaction_10537235": { "compartment": "compartment_172574", "id": "reaction_10537235", "reactome": "R-CEL-1676024", "name": "PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1806195" ], "products": [ "species_1806198", "species_29370" ], "modifiers": [ [ "species_10537193", "catalyst" ] ], "additional_components": [ "Q9TXI7", "WBGene00006932", "species_266099", "Q23669", "WBGene00014151", "G5EDY0", "WBGene00009552", "species_74016", "species_114632" ] }, "reaction_10537123": { "compartment": "compartment_172574", "id": "reaction_10537123", "reactome": "R-CEL-1675795", "name": "PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806198", "species_29356" ], "products": [ "species_29372", "species_1806195" ], "modifiers": [ [ "species_10537120", "catalyst" ] ], "additional_components": [ "Q9N589", "WBGene00003475", "Q22712", "WBGene00003476", "G5ED68", "F53A2.8a" ] }, "reaction_10537247": { "compartment": "compartment_172574", "id": "reaction_10537247", "reactome": "R-CEL-1676065", "name": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1806289" ], "products": [ "species_1806212", "species_29372" ], "modifiers": [ [ "species_10537120", "catalyst" ] ], "additional_components": [ "Q9N589", "WBGene00003475", "Q22712", "WBGene00003476", "G5ED68", "F53A2.8a" ] }, "reaction_10573048": { "compartment": "compartment_7660", "id": "reaction_10573048", "reactome": "R-CEL-9668902", "name": "Formation of the CTF18-RFC(7s) complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502620", "species_10502635", "species_10511819", "species_10502630", "species_10502625" ], "products": [ "species_10511821" ], "modifiers": [], "additional_components": [ "WBGene00018409", "WBGene00004338", "Q22664", "WBGene00011915", "O44992", "WBGene00019595", "Q21350", "WBGene00010676", "WBGene00004339", "WBGene00004340", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "Q22664", "WBGene00011915", "O44992", "WBGene00019595", "Q21350", "WBGene00010676", "O44175", "WBGene00004338", "P34429", "WBGene00018409" ] }, "reaction_10573050": { "compartment": "compartment_7660", "id": "reaction_10573050", "reactome": "R-CEL-9668904", "name": "Formation of the CTF18 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10511807", "species_10511817", "species_10511812" ], "products": [ "species_10511819" ], "modifiers": [], "additional_components": [ "WBGene00010676", "WBGene00019595", "WBGene00011915", "Q22664", "WBGene00011915", "O44992", "WBGene00019595", "Q21350", "WBGene00010676" ] }, "reaction_10555879": { "compartment": "compartment_7660", "id": "reaction_10555879", "reactome": "R-CEL-5685953", "name": "SIRT6 deacetylates RBBP8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10555871", "species_427523" ], "products": [ "species_427497", "species_427498", "species_10555659" ], "modifiers": [ [ "species_10555876", "catalyst" ] ], "additional_components": [ "Q18606", "WBGene00008082", "Q18606", "WBGene00008082", "WBGene00004803" ] }, "reaction_10506532": { "compartment": "compartment_7660", "id": "reaction_10506532", "reactome": "R-CEL-73946", "name": "Abortive initiation after formation of the first phosphodiester bond", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10506530" ], "products": [ "species_10506316", "species_10506438", "species_10506516", "species_109877", "species_10506433", "species_10504433", "species_10506528" ], "modifiers": [], "additional_components": [ "G5EG49", "WBGene00013998", "G5EG47", "WBGene00010054", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "O44625", "WBGene00004136", "Q9NEX2", "WBGene00013736", "Q95ZS0", "WBGene00006392", "Q9GZI6", "WBGene00006387", "G5EF68", "WBGene00006386", "O45784", "WBGene00006391", "P32085", "WBGene00006542", "O61707", "WBGene00006385", "Q9NEW8", "WBGene00006389", "Q9TYN3", "WBGene00006383", "Q18265", "WBGene00016173", "Q17957", "WBGene00006397", "E9P861", "WBGene00006384", "Q20361", "WBGene00006395", "G5EGM3", "WBGene00006382", "O16991", "WBGene00006648", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "WBGene00006648", "Q95ZS0", "WBGene00006392", "Q9GZI6", "WBGene00006387", "G5EF68", "WBGene00006386", "O45784", "WBGene00006391", "P32085", "WBGene00006542", "O61707", "WBGene00006385", "Q9NEW8", "WBGene00006389", "Q9TYN3", "WBGene00006383", "Q18265", "WBGene00016173", "Q17957", "WBGene00006397", "E9P861", "WBGene00006384", "Q20361", "WBGene00006395", "G5EGM3", "WBGene00006382", "O44625", "WBGene00004136", "Q9NEX2", "WBGene00013736", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "G5EG49", "WBGene00013998", "G5EG47", "WBGene00010054" ] }, "reaction_10509383": { "compartment": "compartment_7660", "id": "reaction_10509383", "reactome": "R-CEL-112429", "name": "Formation of FACT complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509276", "species_10509281" ], "products": [ "species_10509283" ], "modifiers": [], "additional_components": [ "WBGene00001974", "WBGene00018849", "Q9N5R9", "WBGene00018849", "P41848", "WBGene00001974" ] }, "reaction_10509385": { "compartment": "compartment_7660", "id": "reaction_10509385", "reactome": "R-CEL-112430", "name": "Formation of P-TEFb complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509215", "species_10509194" ], "products": [ "species_10509217" ], "modifiers": [], "additional_components": [ "P34424", "WBGene00000508", "P34425", "WBGene00000507", "O17869", "WBGene00009650", "WBGene00000410", "Q9TVL3", "WBGene00000410", "P34424", "WBGene00000508", "P34425", "WBGene00000507", "O17869", "WBGene00009650" ] }, "reaction_10507434": { "compartment": "compartment_7660", "id": "reaction_10507434", "reactome": "R-CEL-75862", "name": "Fall Back to Closed Pre-initiation Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10507424" ], "products": [ "species_10507432" ], "modifiers": [], "additional_components": [ "G5EG49", "WBGene00013998", "G5EG47", "WBGene00010054", "O44625", "WBGene00004136", "Q9NEX2", "WBGene00013736", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q95ZS0", "WBGene00006392", "Q9GZI6", "WBGene00006387", "G5EF68", "WBGene00006386", "O45784", "WBGene00006391", "P32085", "WBGene00006542", "O61707", "WBGene00006385", "Q9NEW8", "WBGene00006389", "Q9TYN3", "WBGene00006383", "Q18265", "WBGene00016173", "Q17957", "WBGene00006397", "E9P861", "WBGene00006384", "Q20361", "WBGene00006395", "G5EGM3", "WBGene00006382", "O16991", "WBGene00006648", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "G5EG49", "WBGene00013998", "G5EG47", "WBGene00010054", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q95ZS0", "WBGene00006392", "Q9GZI6", "WBGene00006387", "G5EF68", "WBGene00006386", "O45784", "WBGene00006391", "P32085", "WBGene00006542", "O61707", "WBGene00006385", "Q9NEW8", "WBGene00006389", "Q9TYN3", "WBGene00006383", "Q18265", "WBGene00016173", "Q17957", "WBGene00006397", "E9P861", "WBGene00006384", "Q20361", "WBGene00006395", "G5EGM3", "WBGene00006382", "O44625", "WBGene00004136", "Q9NEX2", "WBGene00013736", "O16991", "WBGene00006648", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529" ] }, "reaction_10509387": { "compartment": "compartment_7660", "id": "reaction_10509387", "reactome": "R-CEL-112434", "name": "Formation of DSIF complex ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508149", "species_10509232" ], "products": [ "species_10509234" ], "modifiers": [], "additional_components": [ "WBGene00005015", "WBGene00005014", "Q9TZ93", "WBGene00005014", "Q21338", "WBGene00005015" ] }, "reaction_10509389": { "compartment": "compartment_7660", "id": "reaction_10509389", "reactome": "R-CEL-112435", "name": "Formation of Elongin BC complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509293", "species_10509288" ], "products": [ "species_10509295" ], "modifiers": [], "additional_components": [ "WBGene00001235", "WBGene00001236", "Q9BKS1", "WBGene00001236", "G5ECR7", "WBGene00001235" ] }, "reaction_10509391": { "compartment": "compartment_7660", "id": "reaction_10509391", "reactome": "R-CEL-112436", "name": "Formation of Elongin complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509295", "species_10509300" ], "products": [ "species_10509306" ], "modifiers": [], "additional_components": [ "Q9BKS1", "WBGene00001236", "G5ECR7", "WBGene00001235", "WBGene00010990", "Q09413", "WBGene00010990", "Q9BKS1", "WBGene00001236", "G5ECR7", "WBGene00001235" ] }, "reaction_10509395": { "compartment": "compartment_7660", "id": "reaction_10509395", "reactome": "R-CEL-113409", "name": "Abortive termination of early transcription elongation by DSIF:NELF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509360" ], "products": [ "species_10509360" ], "modifiers": [], "additional_components": [ "Q9TZ93", "WBGene00005014", "Q21338", "WBGene00005015", "Q9XUM4", "WBGene00012236", "P16356", "WBGene00000123", "Q19826", "WBGene00017830", "Q9XVH6", "WBGene00012187", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q9U3I0", "WBGene00009078", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q10578", "WBGene00016140", "Q17684", "WBGene00007355", "O02092", "WBGene00018391", "Q9GR61", "WBGene00021347", "Q9N3C9", "WBGene00021845", "Q93338", "WBGene00007971", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "Q9TZ93", "WBGene00005014", "Q21338", "WBGene00005015", "Q9XUM4", "WBGene00012236", "P16356", "WBGene00000123", "Q19826", "WBGene00017830", "Q9XVH6", "WBGene00012187", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q9U3I0", "WBGene00009078", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q10578", "WBGene00016140", "Q17684", "WBGene00007355", "O02092", "WBGene00018391", "Q9GR61", "WBGene00021347", "Q9N3C9", "WBGene00021845", "Q93338", "WBGene00007971", "Q93594", "WBGene00009141", "O01763", "WBGene00018156" ] }, "reaction_10509397": { "compartment": "compartment_7660", "id": "reaction_10509397", "reactome": "R-CEL-113411", "name": "2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509365" ], "products": [ "species_10509369" ], "modifiers": [], "additional_components": [ "Q9TXQ9", "WBGene00017011", "Q9TVL3", "WBGene00000410", "P34424", "WBGene00000508", "P34425", "WBGene00000507", "O17869", "WBGene00009650", "Q9N5R9", "WBGene00018849", "P41848", "WBGene00001974", "species_110614", "species_29358", "species_29494", "species_29438", "P34703", "WBGene00001259", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q9N554", "WBGene00021281", "Q9TZ93", "WBGene00005014", "Q21338", "WBGene00005015", "H2KYV0", "WBGene00016115", "P52652", "WBGene00012000", "Q9XUM4", "WBGene00012236", "Q09413", "WBGene00010990", "Q9BKS1", "WBGene00001236", "G5ECR7", "WBGene00001235", "G5EBY0", "WBGene00009103", "Q03560", "WBGene00007184", "A5Z2V7", "WBGene00008533", "Q17431", "WBGene00007110", "P90783", "WBGene00008338", "Q9N5U5", "WBGene00018064", "Q19375", "WBGene00008729", "Q9TXQ9", "WBGene00017011", "Q9TVL3", "WBGene00000410", "P34424", "WBGene00000508", "P34425", "WBGene00000507", "O17869", "WBGene00009650", "Q9N5R9", "WBGene00018849", "P41848", "WBGene00001974", "P34703", "WBGene00001259", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q9N554", "WBGene00021281", "Q9TZ93", "WBGene00005014", "Q21338", "WBGene00005015", "H2KYV0", "WBGene00016115", "P52652", "WBGene00012000", "Q9XUM4", "WBGene00012236", "Q09413", "WBGene00010990", "Q9BKS1", "WBGene00001236", "G5ECR7", "WBGene00001235", "G5EBY0", "WBGene00009103", "Q03560", "WBGene00007184", "A5Z2V7", "WBGene00008533", "Q17431", "WBGene00007110", "P90783", "WBGene00008338", "Q9N5U5", "WBGene00018064", "Q19375", "WBGene00008729" ] }, "reaction_10509401": { "compartment": "compartment_7660", "id": "reaction_10509401", "reactome": "R-CEL-113413", "name": "TFIIS-mediated recovery of elongation from arrest", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509365" ], "products": [ "species_10509365" ], "modifiers": [], "additional_components": [ "Q9TXQ9", "WBGene00017011", "Q9TVL3", "WBGene00000410", "P34424", "WBGene00000508", "P34425", "WBGene00000507", "O17869", "WBGene00009650", "Q9N5R9", "WBGene00018849", "P41848", "WBGene00001974", "species_110614", "species_29358", "species_29494", "species_29438", "P34703", "WBGene00001259", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q9N554", "WBGene00021281", "Q9TZ93", "WBGene00005014", "Q21338", "WBGene00005015", "H2KYV0", "WBGene00016115", "P52652", "WBGene00012000", "Q9XUM4", "WBGene00012236", "Q09413", "WBGene00010990", "Q9BKS1", "WBGene00001236", "G5ECR7", "WBGene00001235", "G5EBY0", "WBGene00009103", "Q03560", "WBGene00007184", "A5Z2V7", "WBGene00008533", "Q17431", "WBGene00007110", "P90783", "WBGene00008338", "Q9N5U5", "WBGene00018064", "Q19375", "WBGene00008729", "Q9TXQ9", "WBGene00017011", "Q9TVL3", "WBGene00000410", "P34424", "WBGene00000508", "P34425", "WBGene00000507", "O17869", "WBGene00009650", "Q9N5R9", "WBGene00018849", "P41848", "WBGene00001974", "species_110614", "species_29358", "species_29494", "species_29438", "P34703", "WBGene00001259", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q9N554", "WBGene00021281", "Q9TZ93", "WBGene00005014", "Q21338", "WBGene00005015", "H2KYV0", "WBGene00016115", "P52652", "WBGene00012000", "Q9XUM4", "WBGene00012236", "Q09413", "WBGene00010990", "Q9BKS1", "WBGene00001236", "G5ECR7", "WBGene00001235", "G5EBY0", "WBGene00009103", "Q03560", "WBGene00007184", "A5Z2V7", "WBGene00008533", "Q17431", "WBGene00007110", "P90783", "WBGene00008338", "Q9N5U5", "WBGene00018064", "Q19375", "WBGene00008729" ] }, "reaction_10509371": { "compartment": "compartment_7660", "id": "reaction_10509371", "reactome": "R-CEL-112392", "name": "Resumption of elongation after recovery from pausing", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509369" ], "products": [ "species_10509365" ], "modifiers": [], "additional_components": [ "Q9TXQ9", "WBGene00017011", "Q9TVL3", "WBGene00000410", "P34424", "WBGene00000508", "P34425", "WBGene00000507", "O17869", "WBGene00009650", "Q9N5R9", "WBGene00018849", "P41848", "WBGene00001974", "P34703", "WBGene00001259", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q9N554", "WBGene00021281", "Q9TZ93", "WBGene00005014", "Q21338", "WBGene00005015", "H2KYV0", "WBGene00016115", "P52652", "WBGene00012000", "Q9XUM4", "WBGene00012236", "Q09413", "WBGene00010990", "Q9BKS1", "WBGene00001236", "G5ECR7", "WBGene00001235", "G5EBY0", "WBGene00009103", "Q03560", "WBGene00007184", "A5Z2V7", "WBGene00008533", "Q17431", "WBGene00007110", "P90783", "WBGene00008338", "Q9N5U5", "WBGene00018064", "Q19375", "WBGene00008729", "Q9TXQ9", "WBGene00017011", "Q9TVL3", "WBGene00000410", "P34424", "WBGene00000508", "P34425", "WBGene00000507", "O17869", "WBGene00009650", "Q9N5R9", "WBGene00018849", "P41848", "WBGene00001974", "species_110614", "species_29358", "species_29494", "species_29438", "P34703", "WBGene00001259", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q9N554", "WBGene00021281", "Q9TZ93", "WBGene00005014", "Q21338", "WBGene00005015", "H2KYV0", "WBGene00016115", "P52652", "WBGene00012000", "Q9XUM4", "WBGene00012236", "Q09413", "WBGene00010990", "Q9BKS1", "WBGene00001236", "G5ECR7", "WBGene00001235", "G5EBY0", "WBGene00009103", "Q03560", "WBGene00007184", "A5Z2V7", "WBGene00008533", "Q17431", "WBGene00007110", "P90783", "WBGene00008338", "Q9N5U5", "WBGene00018064", "Q19375", "WBGene00008729" ] }, "reaction_10509403": { "compartment": "compartment_7660", "id": "reaction_10509403", "reactome": "R-CEL-113414", "name": "7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509365" ], "products": [ "species_10509365" ], "modifiers": [], "additional_components": [ "Q9TXQ9", "WBGene00017011", "Q9TVL3", "WBGene00000410", "P34424", "WBGene00000508", "P34425", "WBGene00000507", "O17869", "WBGene00009650", "Q9N5R9", "WBGene00018849", "P41848", "WBGene00001974", "species_110614", "species_29358", "species_29494", "species_29438", "P34703", "WBGene00001259", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q9N554", "WBGene00021281", "Q9TZ93", "WBGene00005014", "Q21338", "WBGene00005015", "H2KYV0", "WBGene00016115", "P52652", "WBGene00012000", "Q9XUM4", "WBGene00012236", "Q09413", "WBGene00010990", "Q9BKS1", "WBGene00001236", "G5ECR7", "WBGene00001235", "G5EBY0", "WBGene00009103", "Q03560", "WBGene00007184", "A5Z2V7", "WBGene00008533", "Q17431", "WBGene00007110", "P90783", "WBGene00008338", "Q9N5U5", "WBGene00018064", "Q19375", "WBGene00008729", "Q9TXQ9", "WBGene00017011", "Q9TVL3", "WBGene00000410", "P34424", "WBGene00000508", "P34425", "WBGene00000507", "O17869", "WBGene00009650", "Q9N5R9", "WBGene00018849", "P41848", "WBGene00001974", "species_110614", "species_29358", "species_29494", "species_29438", "P34703", "WBGene00001259", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q9N554", "WBGene00021281", "Q9TZ93", "WBGene00005014", "Q21338", "WBGene00005015", "H2KYV0", "WBGene00016115", "P52652", "WBGene00012000", "Q9XUM4", "WBGene00012236", "Q09413", "WBGene00010990", "Q9BKS1", "WBGene00001236", "G5ECR7", "WBGene00001235", "G5EBY0", "WBGene00009103", "Q03560", "WBGene00007184", "A5Z2V7", "WBGene00008533", "Q17431", "WBGene00007110", "P90783", "WBGene00008338", "Q9N5U5", "WBGene00018064", "Q19375", "WBGene00008729" ] }, "reaction_10507581": { "compartment": "compartment_7660", "id": "reaction_10507581", "reactome": "R-CEL-75891", "name": "Abortive Initiation After Second Transition", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10507579" ], "products": [ "species_10506316", "species_75897", "species_10504433", "species_10506528" ], "modifiers": [], "additional_components": [ "G5EG49", "WBGene00013998", "G5EG47", "WBGene00010054", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "G5EG49", "WBGene00013998", "G5EG47", "WBGene00010054" ] }, "reaction_10507422": { "compartment": "compartment_7660", "id": "reaction_10507422", "reactome": "R-CEL-75856", "name": "Abortive Initiation Before Second Transition", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10507420" ], "products": [ "species_10506316", "species_10506438", "species_110068", "species_10506516", "species_10506433", "species_10504433", "species_10506528" ], "modifiers": [], "additional_components": [ "G5EG49", "WBGene00013998", "G5EG47", "WBGene00010054", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "O44625", "WBGene00004136", "Q9NEX2", "WBGene00013736", "Q95ZS0", "WBGene00006392", "Q9GZI6", "WBGene00006387", "G5EF68", "WBGene00006386", "O45784", "WBGene00006391", "P32085", "WBGene00006542", "O61707", "WBGene00006385", "Q9NEW8", "WBGene00006389", "Q9TYN3", "WBGene00006383", "Q18265", "WBGene00016173", "Q17957", "WBGene00006397", "E9P861", "WBGene00006384", "Q20361", "WBGene00006395", "G5EGM3", "WBGene00006382", "O16991", "WBGene00006648", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "WBGene00006648", "Q95ZS0", "WBGene00006392", "Q9GZI6", "WBGene00006387", "G5EF68", "WBGene00006386", "O45784", "WBGene00006391", "P32085", "WBGene00006542", "O61707", "WBGene00006385", "Q9NEW8", "WBGene00006389", "Q9TYN3", "WBGene00006383", "Q18265", "WBGene00016173", "Q17957", "WBGene00006397", "E9P861", "WBGene00006384", "Q20361", "WBGene00006395", "G5EGM3", "WBGene00006382", "O44625", "WBGene00004136", "Q9NEX2", "WBGene00013736", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "G5EG49", "WBGene00013998", "G5EG47", "WBGene00010054" ] }, "reaction_10509375": { "compartment": "compartment_7660", "id": "reaction_10509375", "reactome": "R-CEL-112395", "name": "Abortive termination of elongation after arrest", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509365" ], "products": [ "species_10509373" ], "modifiers": [], "additional_components": [ "Q9TXQ9", "WBGene00017011", "Q9TVL3", "WBGene00000410", "P34424", "WBGene00000508", "P34425", "WBGene00000507", "O17869", "WBGene00009650", "Q9N5R9", "WBGene00018849", "P41848", "WBGene00001974", "species_110614", "species_29358", "species_29494", "species_29438", "P34703", "WBGene00001259", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q9N554", "WBGene00021281", "Q9TZ93", "WBGene00005014", "Q21338", "WBGene00005015", "H2KYV0", "WBGene00016115", "P52652", "WBGene00012000", "Q9XUM4", "WBGene00012236", "Q09413", "WBGene00010990", "Q9BKS1", "WBGene00001236", "G5ECR7", "WBGene00001235", "G5EBY0", "WBGene00009103", "Q03560", "WBGene00007184", "A5Z2V7", "WBGene00008533", "Q17431", "WBGene00007110", "P90783", "WBGene00008338", "Q9N5U5", "WBGene00018064", "Q19375", "WBGene00008729", "Q9TXQ9", "WBGene00017011", "Q9TVL3", "WBGene00000410", "P34424", "WBGene00000508", "P34425", "WBGene00000507", "O17869", "WBGene00009650", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q9N5R9", "WBGene00018849", "P41848", "WBGene00001974", "P34703", "WBGene00001259", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q9N554", "WBGene00021281", "Q9TZ93", "WBGene00005014", "Q21338", "WBGene00005015", "H2KYV0", "WBGene00016115", "P52652", "WBGene00012000", "Q9XUM4", "WBGene00012236", "Q09413", "WBGene00010990", "Q9BKS1", "WBGene00001236", "G5ECR7", "WBGene00001235", "G5EBY0", "WBGene00009103", "Q03560", "WBGene00007184", "A5Z2V7", "WBGene00008533", "Q17431", "WBGene00007110", "P90783", "WBGene00008338", "Q9N5U5", "WBGene00018064", "Q19375", "WBGene00008729" ] }, "reaction_10517522": { "compartment": "compartment_984", "id": "reaction_10517522", "reactome": "R-CEL-264695", "name": "cholesterol + phosphatidylcholine (lecithin) => cholesterol ester + 2-lysophosphatidylcholine (lysolecithin)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_171149", "species_194276" ], "products": [ "species_194236", "species_171076" ], "modifiers": [ [ "species_10517519", "catalyst" ] ], "additional_components": [ "WBGene00010872" ] }, "reaction_10516629": { "compartment": "compartment_984", "id": "reaction_10516629", "reactome": "R-CEL-210420", "name": "Ca2+ influx through voltage gated Ca2+ channels", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74112" ], "products": [ "species_74016" ], "modifiers": [ [ "species_10516626", "catalyst" ], [ "species_74126", "inhibitor" ] ], "additional_components": [ "A0A3B1E663", "WBGene00006742", "G5EBI8", "WBGene00017400", "G5EDT2", "WBGene00007670", "O01661", "WBGene00000368", "A0A078BQJ0", "WBGene00021125" ] }, "reaction_10565831": { "compartment": "compartment_12045", "id": "reaction_10565831", "reactome": "R-CEL-8857686", "name": "FITM1, FITM2 bind TAGs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_549167", "species_10565825" ], "products": [ "species_10565829" ], "modifiers": [], "additional_components": [ "WBGene00044094", "Q5CZ37", "WBGene00044094", "species_171126" ] }, "reaction_10565903": { "compartment": "compartment_70101", "id": "reaction_10565903", "reactome": "R-CEL-8862380", "name": "HSD17B13 binds lipid droplets", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10556974", "species_8866926" ], "products": [ "species_10565901" ], "modifiers": [], "additional_components": [ "A5JYX5", "WBGene00000967", "O18030", "WBGene00000968", "Q19843", "WBGene00000992", "Q22392", "WBGene00000982", "species_171126", "species_8876704", "CHEBI:16247", "species_171126", "species_8876704", "CHEBI:16247", "A5JYX5", "WBGene00000967", "O18030", "WBGene00000968", "Q19843", "WBGene00000992", "Q22392", "WBGene00000982" ] }, "reaction_10542689": { "compartment": "compartment_17957", "id": "reaction_10542689", "reactome": "R-CEL-2089971", "name": "Secretion of collagens", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10542497" ], "products": [ "species_10542687", "species_10540972" ], "modifiers": [], "additional_components": [ "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "A9Z1L1", "WBGene00005648", "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689", "Q19368", "WBGene00000702", "Q21437", "WBGene00000659", "Q9N4U2", "WBGene00000647", "O76368", "WBGene00000674", "Q09457", "WBGene00000251", "P17140", "WBGene00002280", "Q09457", "WBGene00000251", "Q9N4U2", "WBGene00000647", "O76368", "WBGene00000674", "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689", "P17140", "WBGene00002280", "Q21437", "WBGene00000659", "Q19368", "WBGene00000702", "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "A9Z1L1", "WBGene00005648" ] }, "reaction_10536930": { "compartment": "compartment_17957", "id": "reaction_10536930", "reactome": "R-CEL-1650808", "name": "Prolyl 4-hydroxylase converts collagen prolines to 4-hydroxyprolines", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_10536805", "species_1650779" ], "products": [ "species_1650769", "species_10536918", "species_159751" ], "modifiers": [ [ "species_10536927", "catalyst" ] ], "additional_components": [ "O76368", "WBGene00000674", "Q09457", "WBGene00000251", "Q9N4U2", "WBGene00000647", "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689", "Q17770", "WBGene00003963", "Q17770", "WBGene00003963", "CHEBI:29073", "B1V8J4", "WBGene00012815", "Q17770", "WBGene00003963", "species_113531" ] }, "reaction_10539491": { "compartment": "compartment_12045", "id": "reaction_10539491", "reactome": "R-CEL-1981157", "name": "Glucosylation of collagen propeptide hydroxylysines", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_173594", "species_10539158" ], "products": [ "species_158602", "species_10539488" ], "modifiers": [ [ "species_10538479", "catalyst" ] ], "additional_components": [ "species_113531", "Q20679", "WBGene00002497", "species_113531", "Q20679", "WBGene00002497", "species_113531", "Q20679", "WBGene00002497" ] }, "reaction_10568836": { "compartment": "compartment_17957", "id": "reaction_10568836", "reactome": "R-CEL-8948219", "name": "PLOD3 binds Lysyl hydroxylated collagen propeptides", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10538479", "species_10538808" ], "products": [ "species_10539156" ], "modifiers": [], "additional_components": [ "species_113531", "Q20679", "WBGene00002497", "species_113531", "Q20679", "WBGene00002497" ] }, "reaction_10568838": { "compartment": "compartment_17957", "id": "reaction_10568838", "reactome": "R-CEL-8948222", "name": "PLOD3:Fe2+ dimer:Galactosyl-hydroxylysyl collagen propeptides dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10539158" ], "products": [ "species_10538479", "species_10539149" ], "modifiers": [], "additional_components": [ "species_113531", "Q20679", "WBGene00002497", "species_113531", "Q20679", "WBGene00002497" ] }, "reaction_10568840": { "compartment": "compartment_17957", "id": "reaction_10568840", "reactome": "R-CEL-8948224", "name": "PLOD3:Fe2+ dimer:Glucosyl-galactosyl-hydroxylysyl collagen propeptides dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10539488" ], "products": [ "species_10538479", "species_10539486" ], "modifiers": [], "additional_components": [ "species_113531", "Q20679", "WBGene00002497", "species_113531", "Q20679", "WBGene00002497" ] }, "reaction_10568842": { "compartment": "compartment_17957", "id": "reaction_10568842", "reactome": "R-CEL-8948228", "name": "COLGALT1,COLGALT2 bind Lysyl hydroxylated collagen propeptides", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10538808", "species_10538822" ], "products": [ "species_10538824" ], "modifiers": [], "additional_components": [ "Q18989", "WBGene00008426", "Q18989", "WBGene00008426" ] }, "reaction_10540780": { "compartment": "compartment_984", "id": "reaction_10540780", "reactome": "R-CEL-2002428", "name": "Removal of fibrillar collagen N-propeptides", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10540153" ], "products": [ "species_10540761" ], "modifiers": [ [ "species_10540777", "catalyst" ] ], "additional_components": [ "Q09457", "WBGene00000251", "Q9N4U2", "WBGene00000647", "O76368", "WBGene00000674", "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689", "P17140", "WBGene00002280", "Q21437", "WBGene00000659", "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689", "O76368", "WBGene00000674", "Q09457", "WBGene00000251", "Q9N4U2", "WBGene00000647", "P17140", "WBGene00002280", "Q21437", "WBGene00000659", "Q20176", "WBGene00003555", "O76840", "WBGene00003242" ] }, "reaction_10568844": { "compartment": "compartment_17957", "id": "reaction_10568844", "reactome": "R-CEL-8948231", "name": "COLGALT1,COLGALT2:Galactosyl-hydroxylysyl collagen propeptides dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10539151" ], "products": [ "species_10539149", "species_10538822" ], "modifiers": [], "additional_components": [ "Q18989", "WBGene00008426", "Q18989", "WBGene00008426" ] }, "reaction_10568846": { "compartment": "compartment_17957", "id": "reaction_10568846", "reactome": "R-CEL-8948232", "name": "Lysyl hydroxylated collagen propeptides dissociate from Lysyl hydroxylases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10538810" ], "products": [ "species_10538808", "species_10538481" ], "modifiers": [], "additional_components": [ "Q20679", "WBGene00002497", "species_113531", "Q20679", "WBGene00002497", "species_113531" ] }, "reaction_10568848": { "compartment": "compartment_17957", "id": "reaction_10568848", "reactome": "R-CEL-8948234", "name": "P4HB:4-Hyp collagen propeptides dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10536918" ], "products": [ "species_10536685", "species_10536916" ], "modifiers": [], "additional_components": [ "Q17770", "WBGene00003963", "WBGene00003963" ] }, "reaction_10540785": { "compartment": "compartment_984", "id": "reaction_10540785", "reactome": "R-CEL-2002440", "name": "Removal of fibrillar collagen C-propeptides", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10540761" ], "products": [ "species_10534596" ], "modifiers": [ [ "species_10540775", "catalyst" ] ], "additional_components": [ "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689", "O76368", "WBGene00000674", "Q09457", "WBGene00000251", "Q9N4U2", "WBGene00000647", "P17140", "WBGene00002280", "Q21437", "WBGene00000659", "P17140", "WBGene00002280", "O76368", "WBGene00000674", "Q09457", "WBGene00000251", "Q9N4U2", "WBGene00000647", "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689", "Q21437", "WBGene00000659", "WBGene00003555" ] }, "reaction_10539154": { "compartment": "compartment_17957", "id": "reaction_10539154", "reactome": "R-CEL-1981120", "name": "Galactosylation of collagen propeptide hydroxylysines by procollagen galactosyltransferases 1, 2.", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1981137", "species_10538824" ], "products": [ "species_10539151", "species_158602" ], "modifiers": [ [ "species_10538824", "catalyst" ] ], "additional_components": [ "Q18989", "WBGene00008426", "Q18989", "WBGene00008426", "Q18989", "WBGene00008426" ] }, "reaction_10540787": { "compartment": "compartment_17957", "id": "reaction_10540787", "reactome": "R-CEL-2002460", "name": "P4HB binds Collagen chains", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10536685", "species_10536803" ], "products": [ "species_10536805" ], "modifiers": [], "additional_components": [ "WBGene00003963", "O76368", "WBGene00000674", "Q09457", "WBGene00000251", "Q9N4U2", "WBGene00000647", "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689", "O76368", "WBGene00000674", "Q09457", "WBGene00000251", "Q9N4U2", "WBGene00000647", "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689", "Q17770", "WBGene00003963" ] }, "reaction_10542934": { "compartment": "compartment_17957", "id": "reaction_10542934", "reactome": "R-CEL-2152276", "name": "Secretion of transmembrane collagens", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10540944" ], "products": [ "species_10542932" ], "modifiers": [], "additional_components": [ "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689", "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689" ] }, "reaction_10539161": { "compartment": "compartment_12045", "id": "reaction_10539161", "reactome": "R-CEL-1981128", "name": "Galactosylation of collagen propeptide hydroxylysines by PLOD3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1981137", "species_10539156" ], "products": [ "species_158602", "species_10539158" ], "modifiers": [ [ "species_10538479", "catalyst" ] ], "additional_components": [ "species_113531", "Q20679", "WBGene00002497", "species_113531", "Q20679", "WBGene00002497", "species_113531", "Q20679", "WBGene00002497" ] }, "reaction_10538460": { "compartment": "compartment_17957", "id": "reaction_10538460", "reactome": "R-CEL-1980233", "name": "Collagen prolyl 3-hydroxylase converts 4-Hyp collagen to 3,4-Hyp collagen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_10538344", "species_1650779" ], "products": [ "species_10538457", "species_1650769", "species_159751" ], "modifiers": [ [ "species_10538344", "catalyst" ] ], "additional_components": [ "CHEBI:29073", "species_113531", "CHEBI:29073", "species_113531", "CHEBI:29073", "species_113531" ] }, "reaction_10538813": { "compartment": "compartment_12045", "id": "reaction_10538813", "reactome": "R-CEL-1981104", "name": "Procollagen lysyl hydroxylases convert collagen lysines to 5-hydroxylysines", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_10538483", "species_1650779" ], "products": [ "species_10538810", "species_1650769", "species_159751" ], "modifiers": [ [ "species_10538481", "catalyst" ] ], "additional_components": [ "Q20679", "WBGene00002497", "species_113531", "Q20679", "WBGene00002497", "species_113531", "Q20679", "WBGene00002497", "species_113531" ] }, "reaction_10510320": { "compartment": "compartment_70101", "id": "reaction_10510320", "reactome": "R-CEL-164423", "name": "PhosphoChREBP (Thr 666) is exported to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10510226" ], "products": [ "species_10510224" ], "modifiers": [], "additional_components": [ "WBGene00003378", "WBGene00003378" ] }, "reaction_10510228": { "compartment": "compartment_7660", "id": "reaction_10510228", "reactome": "R-CEL-163670", "name": "Nuclear transport of pChREBP (Thr 666) protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10510224" ], "products": [ "species_10510226" ], "modifiers": [], "additional_components": [ "WBGene00003378", "WBGene00003378" ] }, "reaction_10572971": { "compartment": "compartment_70101", "id": "reaction_10572971", "reactome": "R-CEL-9661405", "name": "ABCC1 transports BIL from cytosol to extracellular region (blood)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189386" ], "products": [ "species_9661418" ], "modifiers": [ [ "species_10517853", "catalyst" ] ], "additional_components": [ "WBGene00003407" ] }, "reaction_10516833": { "compartment": "compartment_984", "id": "reaction_10516833", "reactome": "R-CEL-210439", "name": "glutamate uptake by astrocytes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_210382" ], "products": [ "species_29404" ], "modifiers": [ [ "species_10516830", "catalyst" ] ], "additional_components": [] }, "reaction_10503235": { "compartment": "compartment_70101", "id": "reaction_10503235", "reactome": "R-CEL-70606", "name": "glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29404", "species_113592", "species_31633" ], "products": [ "species_29372", "species_29370", "species_29472" ], "modifiers": [ [ "species_10503232", "catalyst" ] ], "additional_components": [ "Q95YD1", "WBGene00001602", "Q9U307", "WBGene00001604", "O02225", "WBGene00001607", "Q9XVU2", "WBGene00001606", "P34497", "WBGene00001603" ] }, "reaction_10544113": { "compartment": "compartment_70101", "id": "reaction_10544113", "reactome": "R-CEL-2395879", "name": "NUDT18 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2395883", "species_29356" ], "products": [ "species_2395817", "species_29372" ], "modifiers": [ [ "species_10544108", "catalyst" ] ], "additional_components": [ "WBGene00003578" ] }, "reaction_10544116": { "compartment": "compartment_70101", "id": "reaction_10544116", "reactome": "R-CEL-2395965", "name": "NUDT18 hydrolyses 8-OH-dADP to 8-OH-dAMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2395963", "species_29356" ], "products": [ "species_29372", "species_2395964" ], "modifiers": [ [ "species_10544108", "catalyst" ] ], "additional_components": [ "WBGene00003578" ] }, "reaction_10543958": { "compartment": "compartment_5460", "id": "reaction_10543958", "reactome": "R-CEL-2393954", "name": "Mitochondrial NUDT9 hydrolyses ADP-ribose to R5P and AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2393945", "species_113521" ], "products": [ "species_2393950", "species_159448" ], "modifiers": [ [ "species_10543955", "catalyst" ] ], "additional_components": [ "Q09297", "WBGene00003583", "species_114632" ] }, "reaction_10543948": { "compartment": "compartment_70101", "id": "reaction_10543948", "reactome": "R-CEL-2393939", "name": "Cytosolic NUDT5 hydrolyses ADP-ribose to R5P and AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1131972" ], "products": [ "species_73578", "species_76577" ], "modifiers": [ [ "species_10543945", "catalyst" ] ], "additional_components": [ "species_114632", "O61902", "WBGene00003579" ] }, "reaction_10544111": { "compartment": "compartment_70101", "id": "reaction_10544111", "reactome": "R-CEL-2395873", "name": "NUDT18 hydrolyses 8-oxo-GDP to 8-oxo-GMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_2395880" ], "products": [ "species_29372", "species_2395877" ], "modifiers": [ [ "species_10544108", "catalyst" ] ], "additional_components": [ "WBGene00003578" ] }, "reaction_10529189": { "compartment": "compartment_876", "id": "reaction_10529189", "reactome": "R-CEL-917730", "name": "Cargo Recognition And Sorting", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10529158", "species_10529187" ], "products": [ "species_10529160", "species_10529185" ], "modifiers": [], "additional_components": [ "O76258", "WBGene00015658", "Q8WTK0", "WBGene00021771", "Q17687", "WBGene00015508", "O44158", "WBGene00016990", "Q4R133", "WBGene00044542", "Q9NA26", "WBGene00013598", "Q17796", "WBGene00004101", "O01498", "WBGene00004109", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "P49632", "WBGene00006728", "species_179838", "O76258", "WBGene00015658", "Q8WTK0", "WBGene00021771", "Q17687", "WBGene00015508", "O44158", "WBGene00016990", "Q4R133", "WBGene00044542", "Q9NA26", "WBGene00013598", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "P49632", "WBGene00006728", "species_179838", "Q17796", "WBGene00004101", "O01498", "WBGene00004109" ] }, "reaction_10529181": { "compartment": "compartment_70101", "id": "reaction_10529181", "reactome": "R-CEL-917696", "name": "Cargo Sequestration", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10529177", "species_10529160" ], "products": [ "species_10529179", "species_10529158" ], "modifiers": [], "additional_components": [ "Q9U354", "WBGene00012193", "Q19519", "WBGene00008919", "Q18258", "WBGene00016167", "O76258", "WBGene00015658", "Q8WTK0", "WBGene00021771", "Q17687", "WBGene00015508", "O44158", "WBGene00016990", "Q4R133", "WBGene00044542", "Q9NA26", "WBGene00013598", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "P49632", "WBGene00006728", "species_179838", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "P49632", "WBGene00006728", "species_179838", "Q9U354", "WBGene00012193", "Q19519", "WBGene00008919", "Q18258", "WBGene00016167", "O76258", "WBGene00015658", "Q8WTK0", "WBGene00021771", "Q17687", "WBGene00015508", "O44158", "WBGene00016990", "Q4R133", "WBGene00044542", "Q9NA26", "WBGene00013598" ] }, "reaction_10529183": { "compartment": "compartment_70101", "id": "reaction_10529183", "reactome": "R-CEL-917700", "name": "MVB Vesicle Formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10529179", "species_10529080" ], "products": [ "species_10529177", "species_10529112" ], "modifiers": [], "additional_components": [ "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "P49632", "WBGene00006728", "species_179838", "Q9U354", "WBGene00012193", "Q19519", "WBGene00008919", "Q18258", "WBGene00016167", "Q9GYK4", "WBGene00020866", "Q9BL60", "WBGene00022027", "Q9U2F6", "WBGene00012903", "O02208", "WBGene00007216", "Q22718", "WBGene00011976", "Q18886", "WBGene00016961", "Q21959", "WBGene00020025", "Q9U354", "WBGene00012193", "Q19519", "WBGene00008919", "Q18258", "WBGene00016167", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "P49632", "WBGene00006728", "species_179838", "Q9GYK4", "WBGene00020866", "Q9BL60", "WBGene00022027", "Q9U2F6", "WBGene00012903", "O02208", "WBGene00007216", "Q22718", "WBGene00011976", "Q18886", "WBGene00016961", "Q21959", "WBGene00020025" ] }, "reaction_10518835": { "compartment": "compartment_876", "id": "reaction_10518835", "reactome": "R-CEL-374922", "name": "Noradrenalin synaptic vesicle docking and priming", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10516749", "species_10516777", "species_10516744", "species_10518823", "species_10516631", "species_10516739" ], "products": [ "species_10518825" ], "modifiers": [ [ "species_10518823", "catalyst" ] ], "additional_components": [ "WBGene00006798", "Q21049", "WBGene00006364", "Q22366", "WBGene00006750", "P27715", "WBGene00006752", "Q9N415", "WBGene00006513", "WBGene00022271", "Q94057", "WBGene00044062", "Q95XH1", "WBGene00022077", "G5EBK2", "WBGene00014084", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q19767", "WBGene00004898", "Q9GNP0", "WBGene00000295", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "species_209789", "Q94986", "WBGene00004267", "WBGene00006757", "G5EEN8", "WBGene00006454", "A5PEW5", "WBGene00004364", "G5EEN8", "WBGene00006454", "A5PEW5", "WBGene00004364", "Q94057", "WBGene00044062", "Q95XH1", "WBGene00022077", "G5EBK2", "WBGene00014084", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q19767", "WBGene00004898", "Q9GNP0", "WBGene00000295", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "species_209789", "Q94986", "WBGene00004267", "P34815", "WBGene00006757", "Q9GUM7", "WBGene00022271", "Q21049", "WBGene00006364", "Q22366", "WBGene00006750", "P27715", "WBGene00006752", "Q9N415", "WBGene00006513", "O16000", "WBGene00006798", "Q94057", "WBGene00044062", "Q95XH1", "WBGene00022077", "G5EBK2", "WBGene00014084", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q19767", "WBGene00004898", "Q9GNP0", "WBGene00000295", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "species_209789", "Q94986", "WBGene00004267" ] }, "reaction_10518409": { "compartment": "compartment_374932", "id": "reaction_10518409", "reactome": "R-CEL-372542", "name": "Loading of dopamine into synaptic veiscles", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_159362" ], "products": [ "species_351601" ], "modifiers": [ [ "species_10518406", "catalyst" ] ], "additional_components": [ "WBGene00000295" ] }, "reaction_10518830": { "compartment": "compartment_984", "id": "reaction_10518830", "reactome": "R-CEL-374899", "name": "Release of noradrenaline at the synapse", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10518825" ], "products": [ "species_10518827", "species_10516825", "species_10516777", "species_10516744", "species_10516631", "species_10516823", "species_10516807", "species_374935" ], "modifiers": [ [ "species_10518825", "catalyst" ] ], "additional_components": [ "G5EEN8", "WBGene00006454", "A5PEW5", "WBGene00004364", "Q94057", "WBGene00044062", "Q95XH1", "WBGene00022077", "G5EBK2", "WBGene00014084", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q19767", "WBGene00004898", "Q9GNP0", "WBGene00000295", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "species_209789", "Q94986", "WBGene00004267", "P34815", "WBGene00006757", "Q9GUM7", "WBGene00022271", "Q21049", "WBGene00006364", "Q22366", "WBGene00006750", "P27715", "WBGene00006752", "Q9N415", "WBGene00006513", "O16000", "WBGene00006798", "WBGene00000295", "WBGene00004267", "Q21049", "WBGene00006364", "Q22366", "WBGene00006750", "P27715", "WBGene00006752", "Q9N415", "WBGene00006513", "WBGene00022271", "WBGene00006757", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "G5EEN8", "WBGene00006454", "A5PEW5", "WBGene00004364", "Q94057", "WBGene00044062", "Q95XH1", "WBGene00022077", "G5EBK2", "WBGene00014084", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q19767", "WBGene00004898", "O16000", "WBGene00006798", "G5EEN8", "WBGene00006454", "A5PEW5", "WBGene00004364", "Q94057", "WBGene00044062", "Q95XH1", "WBGene00022077", "G5EBK2", "WBGene00014084", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q19767", "WBGene00004898", "Q9GNP0", "WBGene00000295", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "species_209789", "Q94986", "WBGene00004267", "P34815", "WBGene00006757", "Q9GUM7", "WBGene00022271", "Q21049", "WBGene00006364", "Q22366", "WBGene00006750", "P27715", "WBGene00006752", "Q9N415", "WBGene00006513", "O16000", "WBGene00006798" ] }, "reaction_10551442": { "compartment": "compartment_70101", "id": "reaction_10551442", "reactome": "R-CEL-5336443", "name": "LIN7, CASK and APBA1 bind", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10519883", "species_10519878", "species_10519873" ], "products": [ "species_10519889" ], "modifiers": [], "additional_components": [ "WBGene00002996", "WBGene00002991", "WBGene00002999", "O17583", "WBGene00002999", "P54936", "WBGene00002991", "A5PEX5", "WBGene00002996" ] }, "reaction_10519891": { "compartment": "compartment_70101", "id": "reaction_10519891", "reactome": "R-CEL-380574", "name": "Dopamine synaptic vesicle docking and priming", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10519854", "species_10516749", "species_10519865", "species_10516777", "species_10516744", "species_10516631", "species_10516739" ], "products": [ "species_10519867" ], "modifiers": [ [ "species_10519854", "catalyst" ], [ "species_10519889", "catalyst" ] ], "additional_components": [ "species_351601", "Q94057", "WBGene00044062", "Q95XH1", "WBGene00022077", "G5EBK2", "WBGene00014084", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q19767", "WBGene00004898", "Q9GNP0", "WBGene00000295", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "Q94986", "WBGene00004267", "WBGene00006798", "Q21049", "WBGene00006364", "Q22366", "WBGene00006750", "P27715", "WBGene00006752", "Q9N415", "WBGene00006513", "WBGene00022271", "WBGene00006757", "G5EEN8", "WBGene00006454", "A5PEW5", "WBGene00004364", "G5EEN8", "WBGene00006454", "A5PEW5", "WBGene00004364", "P34815", "WBGene00006757", "Q9GUM7", "WBGene00022271", "Q21049", "WBGene00006364", "Q22366", "WBGene00006750", "P27715", "WBGene00006752", "Q9N415", "WBGene00006513", "O16000", "WBGene00006798", "species_351601", "Q94057", "WBGene00044062", "Q95XH1", "WBGene00022077", "G5EBK2", "WBGene00014084", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q19767", "WBGene00004898", "Q9GNP0", "WBGene00000295", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "Q94986", "WBGene00004267", "species_351601", "Q94057", "WBGene00044062", "Q95XH1", "WBGene00022077", "G5EBK2", "WBGene00014084", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q19767", "WBGene00004898", "Q9GNP0", "WBGene00000295", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "Q94986", "WBGene00004267", "O17583", "WBGene00002999", "P54936", "WBGene00002991", "A5PEX5", "WBGene00002996" ] }, "reaction_10519942": { "compartment": "compartment_984", "id": "reaction_10519942", "reactome": "R-CEL-380869", "name": "Release of docked dopamine loaded synaptic vesicle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10519867" ], "products": [ "species_380873", "species_10518827", "species_10516777", "species_10516825", "species_10519865", "species_10516744", "species_10516823", "species_10516631", "species_10516807" ], "modifiers": [ [ "species_10519867", "catalyst" ] ], "additional_components": [ "G5EEN8", "WBGene00006454", "A5PEW5", "WBGene00004364", "P34815", "WBGene00006757", "Q9GUM7", "WBGene00022271", "Q21049", "WBGene00006364", "Q22366", "WBGene00006750", "P27715", "WBGene00006752", "Q9N415", "WBGene00006513", "O16000", "WBGene00006798", "species_351601", "Q94057", "WBGene00044062", "Q95XH1", "WBGene00022077", "G5EBK2", "WBGene00014084", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q19767", "WBGene00004898", "Q9GNP0", "WBGene00000295", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "Q94986", "WBGene00004267", "WBGene00000295", "Q21049", "WBGene00006364", "Q22366", "WBGene00006750", "P27715", "WBGene00006752", "Q9N415", "WBGene00006513", "WBGene00004267", "WBGene00022271", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "WBGene00006757", "G5EEN8", "WBGene00006454", "A5PEW5", "WBGene00004364", "Q94057", "WBGene00044062", "Q95XH1", "WBGene00022077", "G5EBK2", "WBGene00014084", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q19767", "WBGene00004898", "O16000", "WBGene00006798", "G5EEN8", "WBGene00006454", "A5PEW5", "WBGene00004364", "P34815", "WBGene00006757", "Q9GUM7", "WBGene00022271", "Q21049", "WBGene00006364", "Q22366", "WBGene00006750", "P27715", "WBGene00006752", "Q9N415", "WBGene00006513", "O16000", "WBGene00006798", "species_351601", "Q94057", "WBGene00044062", "Q95XH1", "WBGene00022077", "G5EBK2", "WBGene00014084", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q19767", "WBGene00004898", "Q9GNP0", "WBGene00000295", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "Q94986", "WBGene00004267" ] }, "reaction_10563003": { "compartment": "compartment_161320", "id": "reaction_10563003", "reactome": "R-CEL-6803753", "name": "NAAA hydrolyses NAEs to FAs and ethanolamine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_6803725" ], "products": [ "species_6803745", "species_6803778" ], "modifiers": [ [ "species_10563000", "catalyst" ] ], "additional_components": [ "CHEBI:71466", "species_5693752", "CHEBI:85299", "CHEBI:85263", "CHEBI:71464", "CHEBI:85262", "species_390435", "species_33549", "species_8934421", "CHEBI:28875", "CHEBI:16196", "species_422506", "Q9GUI1", "WBGene00021917" ] }, "reaction_10565443": { "compartment": "compartment_161320", "id": "reaction_10565443", "reactome": "R-CEL-8853686", "name": "MAN2B1 hydrolyses GlcNAc (Man)5 to GlcNAc (Man)3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_8853396" ], "products": [ "species_6799577", "species_6799594" ], "modifiers": [ [ "species_10565440", "catalyst" ] ], "additional_components": [ "Q20829", "WBGene00018877", "species_216785" ] }, "reaction_10565448": { "compartment": "compartment_161320", "id": "reaction_10565448", "reactome": "R-CEL-8853710", "name": "MANBA hydrolyses GlcNAc:Man", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8853719" ], "products": [ "species_1678743", "species_6799594" ], "modifiers": [ [ "species_10565445", "catalyst" ] ], "additional_components": [ "WBGene00007904" ] }, "reaction_10562091": { "compartment": "compartment_161320", "id": "reaction_10562091", "reactome": "R-CEL-6799581", "name": "MAN2B2 hydrolyses GlcNAc (Man)3 to GlcNAc:Man", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6799577", "species_1605715" ], "products": [ "species_6799594", "species_8853719" ], "modifiers": [ [ "species_10562088", "catalyst" ] ], "additional_components": [ "Q20829", "WBGene00018877", "species_216785" ] }, "reaction_10554447": { "compartment": "compartment_7660", "id": "reaction_10554447", "reactome": "R-CEL-5655892", "name": "POLK incorporates dNMP opposite to damaged DNA base", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30555", "species_10554438" ], "products": [ "species_10554444", "species_113541" ], "modifiers": [ [ "species_10554438", "catalyst" ] ], "additional_components": [ "species_266099", "species_114632", "P34409", "WBGene00017696", "Q95Y97", "WBGene00019767", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "O02115", "WBGene00003955", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "Q09615", "WBGene00014066", "A0A0K3AUS7", "WBGene00021344", "species_266099", "species_114632", "P34409", "WBGene00017696", "Q09615", "WBGene00014066", "Q95Y97", "WBGene00019767", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "O02115", "WBGene00003955", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "A0A0K3AUS7", "WBGene00021344", "species_266099", "species_114632", "P34409", "WBGene00017696", "Q95Y97", "WBGene00019767", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "O02115", "WBGene00003955", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "Q09615", "WBGene00014066", "A0A0K3AUS7", "WBGene00021344" ] }, "reaction_10506096": { "compartment": "compartment_70101", "id": "reaction_10506096", "reactome": "R-CEL-73591", "name": "beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_73588" ], "products": [ "species_113528", "species_73590", "species_31633" ], "modifiers": [ [ "species_10506093", "catalyst" ] ], "additional_components": [ "species_216785", "Q19437", "WBGene00017440" ] }, "reaction_10506128": { "compartment": "compartment_70101", "id": "reaction_10506128", "reactome": "R-CEL-73616", "name": "thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_83960", "species_29364" ], "products": [ "species_29366", "species_73541" ], "modifiers": [ [ "species_10506073", "catalyst" ] ], "additional_components": [ "species_73524", "Q18164", "WBGene00016103", "species_113596" ] }, "reaction_10506130": { "compartment": "compartment_70101", "id": "reaction_10506130", "reactome": "R-CEL-73618", "name": "5,6-dihydrothymine + H2O => beta-ureidoisobutyrate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_73541" ], "products": [ "species_73617" ], "modifiers": [ [ "species_10506083", "catalyst" ] ], "additional_components": [ "Q18677", "WBGene00000964", "species_216785" ] }, "reaction_10506132": { "compartment": "compartment_70101", "id": "reaction_10506132", "reactome": "R-CEL-73620", "name": "beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_73617" ], "products": [ "species_113528", "species_73619", "species_31633" ], "modifiers": [ [ "species_10506093", "catalyst" ] ], "additional_components": [ "species_216785", "Q19437", "WBGene00017440" ] }, "reaction_10506086": { "compartment": "compartment_70101", "id": "reaction_10506086", "reactome": "R-CEL-73589", "name": "5,6-dihydrouracil + H2O => beta-ureidopropionate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_73584" ], "products": [ "species_73588" ], "modifiers": [ [ "species_10506083", "catalyst" ] ], "additional_components": [ "Q18677", "WBGene00000964", "species_216785" ] }, "reaction_10506681": { "compartment": "compartment_70101", "id": "reaction_10506681", "reactome": "R-CEL-74376", "name": "(deoxy)uridine + orthophosphate <=> uracil + (deoxy)ribose 1-phosphate (UPP)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29372", "species_500430" ], "products": [ "species_83962", "species_500244" ], "modifiers": [ [ "species_10506676", "catalyst" ] ], "additional_components": [ "CHEBI:16450", "CHEBI:16704", "CHEBI:28542", "species_112016", "Q23588", "WBGene00022817" ] }, "reaction_10506076": { "compartment": "compartment_70101", "id": "reaction_10506076", "reactome": "R-CEL-73585", "name": "uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_83962", "species_29364" ], "products": [ "species_29366", "species_73584" ], "modifiers": [ [ "species_10506073", "catalyst" ] ], "additional_components": [ "species_73524", "Q18164", "WBGene00016103", "species_113596" ] }, "reaction_10508397": { "compartment": "compartment_70101", "id": "reaction_10508397", "reactome": "R-CEL-109449", "name": "(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C3)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_500347" ], "products": [ "species_500346", "species_29372" ], "modifiers": [ [ "species_10508394", "catalyst" ] ], "additional_components": [ "species_109395", "CHEBI:15918", "species_109366", "species_500742", "species_109402", "CHEBI:15698", "CHEBI:16450", "CHEBI:16704", "species_83928", "CHEBI:17562", "species_114632", "Q09315", "WBGene00017775", "Q95ZJ9", "WBGene00017775" ] }, "reaction_10506641": { "compartment": "compartment_70101", "id": "reaction_10506641", "reactome": "R-CEL-74242", "name": "(deoxy)inosine + orthophosphate <=> hypoxanthine + (deoxy)ribose 1-phosphate (NP)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29372", "species_500172" ], "products": [ "species_113599", "species_500244" ], "modifiers": [ [ "species_10506638", "catalyst" ] ], "additional_components": [ "CHEBI:28997", "species_83927", "CHEBI:28542", "species_112016", "U4PSA1", "WBGene00019298" ] }, "reaction_10544722": { "compartment": "compartment_70101", "id": "reaction_10544722", "reactome": "R-CEL-2509838", "name": "ITPA hydrolyses dITP to dIMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2509835", "species_29356" ], "products": [ "species_111294", "species_109330" ], "modifiers": [ [ "species_10544713", "catalyst" ], [ "species_29926", "catalyst" ] ], "additional_components": [ "Q9GYG4", "WBGene00001823" ] }, "reaction_10506661": { "compartment": "compartment_70101", "id": "reaction_10506661", "reactome": "R-CEL-74248", "name": "(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_500120", "species_29356" ], "products": [ "species_29372", "species_500118" ], "modifiers": [ [ "species_10506658", "catalyst" ] ], "additional_components": [ "species_29602", "species_109330", "species_113578", "CHEBI:16192", "CHEBI:17172", "CHEBI:28997", "species_83927", "CHEBI:16750", "Q95X21", "WBGene00022201", "species_114632" ] }, "reaction_10506663": { "compartment": "compartment_70101", "id": "reaction_10506663", "reactome": "R-CEL-74249", "name": "(deoxy)guanosine + orthophosphate <=> guanine + (deoxy)ribose 1-phosphate (NP)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29372", "species_500245" ], "products": [ "species_83956", "species_500244" ], "modifiers": [ [ "species_10506638", "catalyst" ] ], "additional_components": [ "CHEBI:17172", "CHEBI:16750", "CHEBI:28542", "species_112016", "U4PSA1", "WBGene00019298" ] }, "reaction_10506665": { "compartment": "compartment_70101", "id": "reaction_10506665", "reactome": "R-CEL-74258", "name": "Xanthine + H2O + O2 => Urate + H2O2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_29368", "species_30064" ], "products": [ "species_30034", "species_29408" ], "modifiers": [ [ "species_10506648", "catalyst" ] ], "additional_components": [ "O17892", "WBGene00010083", "CHEBI:44074", "species_113596" ] }, "reaction_10506651": { "compartment": "compartment_70101", "id": "reaction_10506651", "reactome": "R-CEL-74247", "name": "Hypoxanthine + H2O + O2 => Xanthine + H2O2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113599", "species_29356", "species_29368" ], "products": [ "species_29408", "species_30064" ], "modifiers": [ [ "species_10506648", "catalyst" ] ], "additional_components": [ "O17892", "WBGene00010083", "CHEBI:44074", "species_113596" ] }, "reaction_10544716": { "compartment": "compartment_70101", "id": "reaction_10544716", "reactome": "R-CEL-2509827", "name": "ITPA hydrolyses ITP to IMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_2509836" ], "products": [ "species_111294", "species_29602" ], "modifiers": [ [ "species_10544713", "catalyst" ], [ "species_29926", "catalyst" ] ], "additional_components": [ "Q9GYG4", "WBGene00001823" ] }, "reaction_10544719": { "compartment": "compartment_70101", "id": "reaction_10544719", "reactome": "R-CEL-2509831", "name": "ITPA hydrolyses XTP to XMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2509848", "species_29356" ], "products": [ "species_111294", "species_111584" ], "modifiers": [ [ "species_10544713", "catalyst" ], [ "species_29926", "catalyst" ] ], "additional_components": [ "Q9GYG4", "WBGene00001823" ] }, "reaction_10566331": { "compartment": "compartment_7660", "id": "reaction_10566331", "reactome": "R-CEL-8866601", "name": "SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_8866574" ], "products": [ "species_8866608", "species_8866567" ], "modifiers": [ [ "species_10566328", "catalyst" ], [ "species_29892", "catalyst" ] ], "additional_components": [ "Q09374", "WBGene00022673", "species_216785" ] }, "reaction_10565105": { "compartment": "compartment_17963", "id": "reaction_10565105", "reactome": "R-CEL-8851234", "name": "NTPDase4 hydrolyzes nucleoside triphosphates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2022884", "species_8851233" ], "products": [ "species_8851224", "species_8851226" ], "modifiers": [ [ "species_10565099", "catalyst" ] ], "additional_components": [ "species_110614", "species_29494", "species_29438", "species_30187", "species_110094", "species_158602", "species_29420", "CHEBI:18075", "species_74016", "Q18411", "WBGene00016380", "Q21815", "WBGene00003254" ] }, "reaction_10565122": { "compartment": "compartment_984", "id": "reaction_10565122", "reactome": "R-CEL-8851396", "name": "NTPDase6 hydrolyzes nucleoside diphosphates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_8851462" ], "products": [ "species_109277", "species_8851461" ], "modifiers": [ [ "species_10565119", "catalyst" ] ], "additional_components": [ "CHEBI:17808", "species_158602", "species_29420", "species_110094", "species_109402", "species_29602", "species_109395", "species_113578", "species_114632", "species_74016", "Q9XU84", "WBGene00010697" ] }, "reaction_10565129": { "compartment": "compartment_528865", "id": "reaction_10565129", "reactome": "R-CEL-8851494", "name": "NTPDase7 hydrolyzes nucleoside triphosphates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8851517", "species_8851509" ], "products": [ "species_8851513", "species_8851518" ], "modifiers": [ [ "species_10565126", "catalyst" ] ], "additional_components": [ "species_29494", "species_29438", "species_110614", "species_110094", "species_158602", "species_29420", "Q21815", "WBGene00003254", "species_74016" ] }, "reaction_10565115": { "compartment": "compartment_984", "id": "reaction_10565115", "reactome": "R-CEL-8851356", "name": "NTPDase5 hydrolyzes nucleoside diphosphates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_8936165" ], "products": [ "species_8851369", "species_109277" ], "modifiers": [ [ "species_10565112", "catalyst" ] ], "additional_components": [ "species_113582", "species_158602", "species_29420", "species_110094", "species_109402", "species_109395", "species_113578", "species_76577", "species_114632", "species_74016", "Q9XU84", "WBGene00010697" ] }, "reaction_10565102": { "compartment": "compartment_17963", "id": "reaction_10565102", "reactome": "R-CEL-8851225", "name": "NTPDase4 hydrolyzes nucleoside diphosphates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8851224", "species_2022884" ], "products": [ "species_8851226", "species_8851227" ], "modifiers": [ [ "species_10565099", "catalyst" ] ], "additional_components": [ "species_110094", "species_158602", "species_29420", "CHEBI:18075", "species_113578", "species_109366", "species_109402", "species_109395", "species_74016", "Q18411", "WBGene00016380", "Q21815", "WBGene00003254" ] }, "reaction_10506608": { "compartment": "compartment_70101", "id": "reaction_10506608", "reactome": "R-CEL-74213", "name": "Adenine + PRPP => AMP + PPi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73566", "species_83951" ], "products": [ "species_111294", "species_76577" ], "modifiers": [ [ "species_10506605", "catalyst" ] ], "additional_components": [ "P91455", "WBGene00020557" ] }, "reaction_10542967": { "compartment": "compartment_70101", "id": "reaction_10542967", "reactome": "R-CEL-2161187", "name": "N6-methyl-AMP + H2O => IMP + methylamine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_2161190" ], "products": [ "species_2161177", "species_29602" ], "modifiers": [ [ "species_10542964", "catalyst" ] ], "additional_components": [ "Q8IG39", "WBGene00016632", "species_216785" ] }, "reaction_10506631": { "compartment": "compartment_70101", "id": "reaction_10506631", "reactome": "R-CEL-74241", "name": "(2'-deoxy)adenosine + H2O => (2'-deoxy)inosine + NH4+ (ADA)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_500173" ], "products": [ "species_500172", "species_31633" ], "modifiers": [ [ "species_10506628", "catalyst" ] ], "additional_components": [ "species_83909", "CHEBI:17256", "CHEBI:28997", "species_83927", "WBGene00015551" ] }, "reaction_10527223": { "compartment": "compartment_70101", "id": "reaction_10527223", "reactome": "R-CEL-514604", "name": "GMP + NADPH + H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_113578", "species_29364" ], "products": [ "species_29366", "species_29602", "species_31633" ], "modifiers": [ [ "species_10527220", "catalyst" ] ], "additional_components": [ "O16294", "WBGene00017984" ] }, "reaction_10508120": { "compartment": "compartment_70101", "id": "reaction_10508120", "reactome": "R-CEL-76590", "name": "AMP + H2O => IMP + NH4+ (AMPD)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_76577" ], "products": [ "species_29602", "species_31633" ], "modifiers": [ [ "species_10508117", "catalyst" ] ], "additional_components": [ "A0A2C9C377", "WBGene00016415" ] }, "reaction_10506618": { "compartment": "compartment_70101", "id": "reaction_10506618", "reactome": "R-CEL-74215", "name": "guanine or hypoxanthine + PRPP => GMP or IMP + PPi (HPRT1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73566", "species_500259" ], "products": [ "species_111294", "species_500260" ], "modifiers": [ [ "species_10506615", "catalyst" ] ], "additional_components": [ "species_83956", "species_113599", "species_29602", "species_113578", "Q9NF11", "WBGene00013690", "species_114632" ] }, "reaction_10508442": { "compartment": "compartment_70101", "id": "reaction_10508442", "reactome": "R-CEL-109624", "name": "(2'-deoxy)adenosine + ATP => (d)AMP + ADP (ADK)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_500173", "species_113592" ], "products": [ "species_500088", "species_29370" ], "modifiers": [ [ "species_10508439", "catalyst" ] ], "additional_components": [ "species_83909", "CHEBI:17256", "species_76577", "species_109386", "Q93934", "WBGene00011128", "species_114632" ] }, "reaction_10508640": { "compartment": "compartment_70101", "id": "reaction_10508640", "reactome": "R-CEL-110138", "name": "AK5,7,8,9 phosphorylates (d)NMPs to (d)NDPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6788778", "species_113592" ], "products": [ "species_29370", "species_6788782" ], "modifiers": [ [ "species_10508635", "catalyst" ] ], "additional_components": [ "species_76577", "species_109395", "CHEBI:15918", "species_109386", "species_113582", "CHEBI:28846", "CHEBI:16174", "species_110094", "Q20140", "WBGene00009531" ] }, "reaction_10508896": { "compartment": "compartment_70101", "id": "reaction_10508896", "reactome": "R-CEL-111746", "name": "glutaredoxin (oxidized) + glutathione (reduced) => glutaredoxin (reduced) + glutathione (oxidized)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29450", "species_10508874" ], "products": [ "species_10508871", "species_111745" ], "modifiers": [ [ "species_10508874", "catalyst" ] ], "additional_components": [ "WBGene00021331", "WBGene00021331", "WBGene00021331" ] }, "reaction_10506017": { "compartment": "compartment_70101", "id": "reaction_10506017", "reactome": "R-CEL-73548", "name": "(d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP (CMPK1)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_500009", "species_113592" ], "products": [ "species_29370", "species_500006" ], "modifiers": [ [ "species_10506014", "catalyst" ] ], "additional_components": [ "species_109395", "CHEBI:15918", "species_109402", "species_158602", "CHEBI:28846", "species_110094", "Q20230", "WBGene00009575" ] }, "reaction_10508642": { "compartment": "compartment_70101", "id": "reaction_10508642", "reactome": "R-CEL-110141", "name": "(d)ADP + ADP <=> (d)AMP + ATP (AK1)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29370", "species_500087" ], "products": [ "species_500088", "species_113592" ], "modifiers": [ [ "species_10506620", "catalyst" ] ], "additional_components": [ "species_113582", "CHEBI:16174", "species_76577", "species_109386", "Q20140", "WBGene00009531" ] }, "reaction_10508899": { "compartment": "compartment_70101", "id": "reaction_10508899", "reactome": "R-CEL-111751", "name": "RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8866401", "species_10506160" ], "products": [ "species_10506158", "species_29356", "species_8866399" ], "modifiers": [ [ "species_10508890", "catalyst" ], [ "species_113592", "catalyst" ], [ "species_110644", "inhibitor" ] ], "additional_components": [ "WBGene00015062", "WBGene00015062", "Q03604", "WBGene00004391", "P42170", "WBGene00004392", "species_912516" ] }, "reaction_10563109": { "compartment": "compartment_70101", "id": "reaction_10563109", "reactome": "R-CEL-6806877", "name": "NME1:NME3 heterohexamer, NME2P1 phosphorylate NDPs to NTPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_6806885" ], "products": [ "species_29370", "species_6806881" ], "modifiers": [ [ "species_10563106", "catalyst" ] ], "additional_components": [ "Q93576", "WBGene00009119", "Q7KX00", "WBGene00021692" ] }, "reaction_10526887": { "compartment": "compartment_70101", "id": "reaction_10526887", "reactome": "R-CEL-482619", "name": "(d)NDP + ATP <=> (d)NTP + ADP (NME1,2,3)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_482627" ], "products": [ "species_29370", "species_482625" ], "modifiers": [ [ "species_10526884", "catalyst" ] ], "additional_components": [ "species_158602", "CHEBI:28846", "CHEBI:16174", "species_29420", "CHEBI:28850", "CHEBI:28862", "CHEBI:18075", "species_110094", "species_29892", "species_110644", "species_30185", "species_29494", "species_30187", "species_110614", "species_500739", "species_29438", "Q93576", "WBGene00009119", "Q7KX00", "WBGene00021692" ] }, "reaction_10506152": { "compartment": "compartment_70101", "id": "reaction_10506152", "reactome": "R-CEL-73635", "name": "dUMP or TMP + ATP <=> dUDP or TDP + ADP [DTYMK]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_499997", "species_113592" ], "products": [ "species_29370", "species_499999" ], "modifiers": [ [ "species_10506149", "catalyst" ] ], "additional_components": [ "species_500742", "species_109366", "CHEBI:28850", "CHEBI:18075", "Q22018", "WBGene00011272" ] }, "reaction_10508650": { "compartment": "compartment_70101", "id": "reaction_10508650", "reactome": "R-CEL-110144", "name": "ADP + ADP <=> AMP + ATP [AK2]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29370" ], "products": [ "species_113592", "species_76577" ], "modifiers": [ [ "species_10508647", "catalyst" ] ], "additional_components": [ "WBGene00002879" ] }, "reaction_10508908": { "compartment": "compartment_70101", "id": "reaction_10508908", "reactome": "R-CEL-111804", "name": "RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8866401", "species_10506160" ], "products": [ "species_10506158", "species_29356", "species_8866399" ], "modifiers": [ [ "species_10508905", "catalyst" ], [ "species_113592", "catalyst" ], [ "species_110644", "inhibitor" ] ], "additional_components": [ "WBGene00015062", "WBGene00015062", "Q03604", "WBGene00004391", "P42170", "WBGene00004392", "species_912516" ] }, "reaction_10527086": { "compartment": "compartment_5460", "id": "reaction_10527086", "reactome": "R-CEL-482804", "name": "(d)NDP + ATP <=> (d)NTP + ADP (NME4)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113593", "species_482803" ], "products": [ "species_113581", "species_482807" ], "modifiers": [ [ "species_10527083", "catalyst" ] ], "additional_components": [ "CHEBI:18075", "species_29420", "CHEBI:28850", "CHEBI:28862", "species_158602", "CHEBI:16174", "CHEBI:28846", "species_110094", "species_110614", "species_29438", "species_500739", "species_29892", "species_29494", "species_110644", "species_30185", "species_30187", "Q7KX00", "WBGene00021692", "Q93576", "WBGene00009119" ] }, "reaction_10506180": { "compartment": "compartment_70101", "id": "reaction_10506180", "reactome": "R-CEL-73647", "name": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_29494", "species_29472" ], "products": [ "species_29372", "species_29404", "species_29370", "species_110614" ], "modifiers": [ [ "species_10506177", "catalyst" ] ], "additional_components": [ "G5EC98", "WBGene00012316" ] }, "reaction_10506116": { "compartment": "compartment_70101", "id": "reaction_10506116", "reactome": "R-CEL-73605", "name": "dUMP + N5,N10-methylene tetrahydrofolate => TMP + dihydrofolate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111355", "species_109382" ], "products": [ "species_109366", "species_73604" ], "modifiers": [ [ "species_10506113", "catalyst" ] ], "additional_components": [ "species_114632", "Q9N588", "WBGene00022455" ] }, "reaction_10527109": { "compartment": "compartment_70101", "id": "reaction_10527109", "reactome": "R-CEL-504054", "name": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_29494", "species_29472" ], "products": [ "species_29372", "species_29404", "species_29370", "species_110614" ], "modifiers": [ [ "species_10527106", "catalyst" ] ], "additional_components": [ "G5EC98", "WBGene00012316" ] }, "reaction_10566276": { "compartment": "compartment_70101", "id": "reaction_10566276", "reactome": "R-CEL-8866405", "name": "RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508871", "species_8866401" ], "products": [ "species_29356", "species_10508874", "species_8866399" ], "modifiers": [ [ "species_10508905", "catalyst" ], [ "species_113592", "catalyst" ], [ "species_110644", "inhibitor" ] ], "additional_components": [ "WBGene00021331", "WBGene00021331", "Q03604", "WBGene00004391", "P42170", "WBGene00004392", "species_912516" ] }, "reaction_10558343": { "compartment": "compartment_7660", "id": "reaction_10558343", "reactome": "R-CEL-6788810", "name": "AK6 phosphorylates (d)NMPs to (d)NDPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_6788813" ], "products": [ "species_113582", "species_6788807" ], "modifiers": [ [ "species_10558340", "catalyst" ] ], "additional_components": [ "CHEBI:15918", "species_109395", "species_76577", "species_109386", "species_110094", "CHEBI:16174", "CHEBI:28846", "species_113582", "WBGene00008458" ] }, "reaction_10506190": { "compartment": "compartment_7660", "id": "reaction_10506190", "reactome": "R-CEL-73666", "name": "dUTP + H2O => dUMP + pyrophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_500739" ], "products": [ "species_113541", "species_500742" ], "modifiers": [ [ "species_10506187", "catalyst" ] ], "additional_components": [ "G5EET2", "WBGene00010609" ] }, "reaction_10508631": { "compartment": "compartment_70101", "id": "reaction_10508631", "reactome": "R-CEL-110133", "name": "(d)GDP + ADP <=> (d)GMP + ATP (GUK1)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29370", "species_500077" ], "products": [ "species_113592", "species_500071" ], "modifiers": [ [ "species_10506329", "catalyst" ] ], "additional_components": [ "species_29420", "CHEBI:28862", "species_113578", "CHEBI:16192", "WBGene00020190" ] }, "reaction_10508893": { "compartment": "compartment_70101", "id": "reaction_10508893", "reactome": "R-CEL-111742", "name": "RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508871", "species_8866401" ], "products": [ "species_29356", "species_10508874", "species_8866399" ], "modifiers": [ [ "species_10508890", "catalyst" ], [ "species_113592", "catalyst" ], [ "species_110644", "inhibitor" ] ], "additional_components": [ "WBGene00021331", "WBGene00021331", "Q03604", "WBGene00004391", "P42170", "WBGene00004392", "species_912516" ] }, "reaction_10508638": { "compartment": "compartment_70101", "id": "reaction_10508638", "reactome": "R-CEL-110137", "name": "(d)ADP or (d)CDP + ADP <=> (d)AMP or (d)CMP + ATP", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29370", "species_6788782" ], "products": [ "species_6788778", "species_113592" ], "modifiers": [ [ "species_10508635", "catalyst" ] ], "additional_components": [ "species_113582", "CHEBI:28846", "CHEBI:16174", "species_110094", "species_76577", "species_109395", "CHEBI:15918", "species_109386", "Q20140", "WBGene00009531" ] }, "reaction_10542971": { "compartment": "compartment_70101", "id": "reaction_10542971", "reactome": "R-CEL-2161500", "name": "abacavir [extracellular] => abacavir [cytosol]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2161525" ], "products": [ "species_2161185" ], "modifiers": [ [ "species_10518788", "catalyst" ] ], "additional_components": [ "WBGene00003987" ] }, "reaction_10510416": { "compartment": "compartment_5460", "id": "reaction_10510416", "reactome": "R-CEL-164834", "name": "Enzyme-bound ATP is released", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10510410", "species_163953" ], "products": [ "species_113529", "species_113593", "species_10510406" ], "modifiers": [ [ "species_10510410", "catalyst" ] ], "additional_components": [ "O16314", "WBGene00015460", "Q18803", "WBGene00000210", "Q17763", "WBGene00007385", "Q19126", "WBGene00000207", "Q9BKS0", "WBGene00022336", "Q21732", "WBGene00011015", "O16517", "WBGene00020275", "Q22021", "WBGene00011273", "Q09544", "WBGene00019061", "Q9XXK1", "WBGene00010419", "O16298", "WBGene00017982", "P46561", "WBGene00000229", "Q95XJ0", "WBGene00022089", "Q7JNG1", "WBGene00000230", "species_29358", "O16314", "WBGene00015460", "Q18803", "WBGene00000210", "Q17763", "WBGene00007385", "Q19126", "WBGene00000207", "Q9BKS0", "WBGene00022336", "Q21732", "WBGene00011015", "O16517", "WBGene00020275", "Q22021", "WBGene00011273", "Q09544", "WBGene00019061", "Q9XXK1", "WBGene00010419", "O16298", "WBGene00017982", "P46561", "WBGene00000229", "Q95XJ0", "WBGene00022089", "Q7JNG1", "WBGene00000230", "O16314", "WBGene00015460", "Q18803", "WBGene00000210", "Q17763", "WBGene00007385", "Q19126", "WBGene00000207", "Q9BKS0", "WBGene00022336", "Q21732", "WBGene00011015", "O16517", "WBGene00020275", "Q22021", "WBGene00011273", "Q09544", "WBGene00019061", "Q9XXK1", "WBGene00010419", "O16298", "WBGene00017982", "P46561", "WBGene00000229", "Q95XJ0", "WBGene00022089", "Q7JNG1", "WBGene00000230", "species_29358" ] }, "reaction_10510418": { "compartment": "compartment_5460", "id": "reaction_10510418", "reactome": "R-CEL-164840", "name": "ADP and Pi bind to ATPase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113548", "species_113581", "species_10510406" ], "products": [ "species_10510408" ], "modifiers": [], "additional_components": [ "O16314", "WBGene00015460", "Q18803", "WBGene00000210", "Q17763", "WBGene00007385", "Q19126", "WBGene00000207", "Q9BKS0", "WBGene00022336", "Q21732", "WBGene00011015", "O16517", "WBGene00020275", "Q22021", "WBGene00011273", "Q09544", "WBGene00019061", "Q9XXK1", "WBGene00010419", "O16298", "WBGene00017982", "P46561", "WBGene00000229", "Q95XJ0", "WBGene00022089", "Q7JNG1", "WBGene00000230", "O16314", "WBGene00015460", "Q18803", "WBGene00000210", "Q17763", "WBGene00007385", "Q19126", "WBGene00000207", "Q9BKS0", "WBGene00022336", "Q21732", "WBGene00011015", "O16517", "WBGene00020275", "Q22021", "WBGene00011273", "Q09544", "WBGene00019061", "Q9XXK1", "WBGene00010419", "O16298", "WBGene00017982", "P46561", "WBGene00000229", "Q95XJ0", "WBGene00022089", "Q7JNG1", "WBGene00000230", "species_113582", "species_29372" ] }, "reaction_10510413": { "compartment": "compartment_5460", "id": "reaction_10510413", "reactome": "R-CEL-164832", "name": "ATPase synthesizes ATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10510408" ], "products": [ "species_10510410", "species_113521" ], "modifiers": [ [ "species_10510408", "catalyst" ] ], "additional_components": [ "O16314", "WBGene00015460", "Q18803", "WBGene00000210", "Q17763", "WBGene00007385", "Q19126", "WBGene00000207", "Q9BKS0", "WBGene00022336", "Q21732", "WBGene00011015", "O16517", "WBGene00020275", "Q22021", "WBGene00011273", "Q09544", "WBGene00019061", "Q9XXK1", "WBGene00010419", "O16298", "WBGene00017982", "P46561", "WBGene00000229", "Q95XJ0", "WBGene00022089", "Q7JNG1", "WBGene00000230", "species_113582", "species_29372", "O16314", "WBGene00015460", "Q18803", "WBGene00000210", "Q17763", "WBGene00007385", "Q19126", "WBGene00000207", "Q9BKS0", "WBGene00022336", "Q21732", "WBGene00011015", "O16517", "WBGene00020275", "Q22021", "WBGene00011273", "Q09544", "WBGene00019061", "Q9XXK1", "WBGene00010419", "O16298", "WBGene00017982", "P46561", "WBGene00000229", "Q95XJ0", "WBGene00022089", "Q7JNG1", "WBGene00000230", "species_29358", "O16314", "WBGene00015460", "Q18803", "WBGene00000210", "Q17763", "WBGene00007385", "Q19126", "WBGene00000207", "Q9BKS0", "WBGene00022336", "Q21732", "WBGene00011015", "O16517", "WBGene00020275", "Q22021", "WBGene00011273", "Q09544", "WBGene00019061", "Q9XXK1", "WBGene00010419", "O16298", "WBGene00017982", "P46561", "WBGene00000229", "Q95XJ0", "WBGene00022089", "Q7JNG1", "WBGene00000230", "species_113582", "species_29372" ] }, "reaction_10546133": { "compartment": "compartment_5460", "id": "reaction_10546133", "reactome": "R-CEL-2995334", "name": "COX15 transforms heme O to heme A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2995328" ], "products": [ "species_2995348" ], "modifiers": [ [ "species_10546130", "catalyst" ] ], "additional_components": [ "WBGene00011526" ] }, "reaction_10529229": { "compartment": "compartment_876", "id": "reaction_10529229", "reactome": "R-CEL-917979", "name": "ABCG2 tetramer transports heme from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_71185" ], "products": [ "species_29372", "species_917877", "species_29370" ], "modifiers": [ [ "species_10529226", "catalyst" ] ], "additional_components": [ "D7SFK1", "WBGene00006522" ] }, "reaction_10546125": { "compartment": "compartment_5460", "id": "reaction_10546125", "reactome": "R-CEL-2995330", "name": "COX10 transforms heme to heme O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189444", "species_2162257", "species_113521" ], "products": [ "species_2995328", "species_159450" ], "modifiers": [ [ "species_10546122", "catalyst" ] ], "additional_components": [ "WBGene00012895" ] }, "reaction_10512862": { "compartment": "compartment_5460", "id": "reaction_10512862", "reactome": "R-CEL-189465", "name": "FECH binds Fe2+ to PRIN9 to form heme", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189487", "species_113531" ], "products": [ "species_113529", "species_189444" ], "modifiers": [ [ "species_10512859", "catalyst" ], [ "species_391232", "inhibitor" ] ], "additional_components": [ "G5EBW5", "WBGene00010645" ] }, "reaction_10572969": { "compartment": "compartment_70101", "id": "reaction_10572969", "reactome": "R-CEL-9661397", "name": "SLCO1B1 transports BIL from extracellular region (blood) to cytosol (hepatocyte)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9661418" ], "products": [ "species_189386" ], "modifiers": [ [ "species_10528178", "catalyst" ] ], "additional_components": [ "Q95ZT3", "WBGene00018568", "O62421", "WBGene00018568", "Q20538", "WBGene00018568", "Q93550", "WBGene00018568" ] }, "reaction_10573000": { "compartment": "compartment_70101", "id": "reaction_10573000", "reactome": "R-CEL-9661799", "name": "SLCO1B3 transports BIL from extracellular region (blood) to cytosol (hepatocyte)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9661418" ], "products": [ "species_189386" ], "modifiers": [ [ "species_10572997", "catalyst" ] ], "additional_components": [ "Q93550", "WBGene00018568", "Q95ZT3", "WBGene00018568", "O62421", "WBGene00018568", "Q20538", "WBGene00018568" ] }, "reaction_10572987": { "compartment": "compartment_876", "id": "reaction_10572987", "reactome": "R-CEL-9661723", "name": "SLCO2B1-3 transports BIL from extracellular region (blood) to cytosol (hepatocyte)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9661418" ], "products": [ "species_189386" ], "modifiers": [ [ "species_10572984", "catalyst" ] ], "additional_components": [ "O62421", "WBGene00018568", "Q20538", "WBGene00018568", "Q93550", "WBGene00018568", "Q95ZT3", "WBGene00018568" ] }, "reaction_10573004": { "compartment": "compartment_70101", "id": "reaction_10573004", "reactome": "R-CEL-9663492", "name": "BIL dissociates from GSTA1, FABP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10573002" ], "products": [ "species_189386", "species_10551347" ], "modifiers": [], "additional_components": [ "O02324", "WBGene00002260", "O01812", "WBGene00002258", "O01814", "WBGene00002257", "O02323", "WBGene00002259", "species_189386", "O02324", "WBGene00002260", "O01812", "WBGene00002258", "O01814", "WBGene00002257", "O02323", "WBGene00002259" ] }, "reaction_10573006": { "compartment": "compartment_70101", "id": "reaction_10573006", "reactome": "R-CEL-9663511", "name": "BIL binds GSTA1, FABP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189386", "species_10551347" ], "products": [ "species_10573002" ], "modifiers": [], "additional_components": [ "O02324", "WBGene00002260", "O01812", "WBGene00002258", "O01814", "WBGene00002257", "O02323", "WBGene00002259", "O02324", "WBGene00002260", "O01812", "WBGene00002258", "O01814", "WBGene00002257", "O02323", "WBGene00002259", "species_189386" ] }, "reaction_10572974": { "compartment": "compartment_70101", "id": "reaction_10572974", "reactome": "R-CEL-9661417", "name": "ABCG2 tetramer transports BMG,BDG from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_5679042" ], "products": [ "species_29372", "species_5679034", "species_29370" ], "modifiers": [ [ "species_10529226", "catalyst" ] ], "additional_components": [ "CHEBI:18392", "CHEBI:16427", "CHEBI:16427", "CHEBI:18392", "D7SFK1", "WBGene00006522" ] }, "reaction_10535157": { "compartment": "compartment_70101", "id": "reaction_10535157", "reactome": "R-CEL-1497810", "name": "Uncoupled eNOS favours the formation of superoxide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_29364" ], "products": [ "species_1222424", "species_29366" ], "modifiers": [ [ "species_10535152", "catalyst" ] ], "additional_components": [ "Q9XTG7", "WBGene00000103", "G4S4W1", "WBGene00016980", "Q17941", "WBGene00000102", "species_74016", "Q11083", "WBGene00020378", "P04630", "WBGene00000285", "G5EF37", "WBGene00003934", "A0A2C9C3L3", "WBGene00020378", "Q18136", "WBGene00006861", "Q09665", "WBGene00006583", "O02159", "WBGene00020378", "G5EDZ8", "WBGene00000288", "Q94288", "WBGene00000287", "Q09980", "WBGene00017394", "O16305", "WBGene00000552", "G5EEG0", "WBGene00000286", "Q18688", "WBGene00000915", "species_1497857", "species_71185", "species_216785", "species_73524", "species_113596", "species_29870" ] }, "reaction_10551508": { "compartment": "compartment_70101", "id": "reaction_10551508", "reactome": "R-CEL-5340226", "name": "CYGB dioxygenates NO", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_202124", "species_10551503", "species_70106", "species_29364" ], "products": [ "species_10551501", "species_432031", "species_29366" ], "modifiers": [ [ "species_10551503", "catalyst" ] ], "additional_components": [ "species_113534", "species_71185", "O17824", "WBGene00008996", "species_71185", "O17824", "WBGene00008996", "species_113534", "species_71185", "O17824", "WBGene00008996" ] }, "reaction_10567554": { "compartment": "compartment_70101", "id": "reaction_10567554", "reactome": "R-CEL-8876789", "name": "CARNMT1 methylates CARN to Anserine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6786250", "species_71284" ], "products": [ "species_71285", "species_8876775" ], "modifiers": [ [ "species_10567551", "catalyst" ] ], "additional_components": [ "WBGene00013015" ] }, "reaction_10503510": { "compartment": "compartment_70101", "id": "reaction_10503510", "reactome": "R-CEL-70903", "name": "urocanate + H2O => 4-imidazolone-5-propionate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_30721" ], "products": [ "species_34979" ], "modifiers": [ [ "species_10503507", "catalyst" ] ], "additional_components": [ "species_29360", "Q9NAE2", "WBGene00013103" ] }, "reaction_10503500": { "compartment": "compartment_70101", "id": "reaction_10503500", "reactome": "R-CEL-70899", "name": "histidine => urocanate + NH4+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29612" ], "products": [ "species_31633", "species_30721" ], "modifiers": [ [ "species_10503497", "catalyst" ] ], "additional_components": [ "WBGene00009813" ] }, "reaction_10503518": { "compartment": "compartment_70101", "id": "reaction_10503518", "reactome": "R-CEL-70906", "name": "4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_34979" ], "products": [ "species_30158", "species_70106" ], "modifiers": [ [ "species_10503515", "catalyst" ] ], "additional_components": [ "WBGene00020436" ] }, "reaction_10571277": { "compartment": "compartment_70101", "id": "reaction_10571277", "reactome": "R-CEL-9014641", "name": "HRSP12 deaminates 2AA to 2OBUTA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9014643" ], "products": [ "species_29382", "species_936714" ], "modifiers": [ [ "species_10571274", "catalyst" ] ], "additional_components": [ "WBGene00016011" ] }, "reaction_10503714": { "compartment": "compartment_5460", "id": "reaction_10503714", "reactome": "R-CEL-71037", "name": "alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_113526", "species_70951" ], "products": [ "species_70955", "species_29362", "species_29376" ], "modifiers": [ [ "species_10503711", "catalyst" ] ], "additional_components": [ "O61199", "WBGene00020679", "species_8878387", "CHEBI:17460", "O45148", "WBGene00020950", "O17953", "WBGene00010794", "species_113596" ] }, "reaction_10503541": { "compartment": "compartment_5460", "id": "reaction_10503541", "reactome": "R-CEL-70941", "name": "alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113526", "species_113556", "species_113521" ], "products": [ "species_113529", "species_508531", "species_29362" ], "modifiers": [ [ "species_10503538", "catalyst" ] ], "additional_components": [ "P46562", "WBGene00000115" ] }, "reaction_10503528": { "compartment": "compartment_5460", "id": "reaction_10503528", "reactome": "R-CEL-70938", "name": "lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113594", "species_113529", "species_29444", "species_113600" ], "products": [ "species_113563", "species_113521", "species_30176" ], "modifiers": [ [ "species_10503525", "catalyst" ] ], "additional_components": [ "U4PFH6", "WBGene00019819" ] }, "reaction_10503531": { "compartment": "compartment_5460", "id": "reaction_10503531", "reactome": "R-CEL-70940", "name": "saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113526", "species_113521", "species_30176" ], "products": [ "species_113529", "species_113556", "species_29362", "species_113552" ], "modifiers": [ [ "species_10503525", "catalyst" ] ], "additional_components": [ "U4PFH6", "WBGene00019819" ] }, "reaction_10518299": { "compartment": "compartment_5460", "id": "reaction_10518299", "reactome": "R-CEL-372480", "name": "2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113594", "species_113577" ], "products": [ "species_29406", "species_70951" ], "modifiers": [ [ "species_10518296", "catalyst" ] ], "additional_components": [ "WBGene00011226" ] }, "reaction_10503724": { "compartment": "compartment_5460", "id": "reaction_10503724", "reactome": "R-CEL-71046", "name": "glutaryl-CoA + FAD => crotonyl-CoA + FADH2 + CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113596", "species_70955" ], "products": [ "species_71045", "species_31649", "species_29376" ], "modifiers": [ [ "species_10503721", "catalyst" ] ], "additional_components": [ "Q20772", "WBGene00010052", "species_113596" ] }, "reaction_10558014": { "compartment": "compartment_17951", "id": "reaction_10558014", "reactome": "R-CEL-6783880", "name": "PIPOX oxidises PPCA to P6C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113535", "species_5693325" ], "products": [ "species_113575", "species_6783877" ], "modifiers": [ [ "species_10558011", "catalyst" ] ], "additional_components": [ "WBGene00015783" ] }, "reaction_10570157": { "compartment": "compartment_70101", "id": "reaction_10570157", "reactome": "R-CEL-8959510", "name": "SEPHS2 phosphorylates H2Se to form SELP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5357660", "species_29356", "species_113592" ], "products": [ "species_29372", "species_70106", "species_8959518", "species_76577" ], "modifiers": [ [ "species_10570154", "catalyst" ] ], "additional_components": [ "WBGene00012867" ] }, "reaction_10551250": { "compartment": "compartment_70101", "id": "reaction_10551250", "reactome": "R-CEL-5263616", "name": "MeSeO2H is reduced to MeSeOH by TXNRD1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5357694", "species_70106", "species_29364" ], "products": [ "species_5357663", "species_29356", "species_29366" ], "modifiers": [ [ "species_10506167", "catalyst" ] ], "additional_components": [ "Q17745", "WBGene00015553", "species_113596" ] }, "reaction_10551247": { "compartment": "compartment_70101", "id": "reaction_10551247", "reactome": "R-CEL-5263614", "name": "MeSeOH is reduced to MeSeH by TXNRD1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5357663", "species_70106", "species_29364" ], "products": [ "species_29356", "species_29366", "species_5357669" ], "modifiers": [ [ "species_10506167", "catalyst" ] ], "additional_components": [ "Q17745", "WBGene00015553", "species_113596" ] }, "reaction_10518289": { "compartment": "compartment_70101", "id": "reaction_10518289", "reactome": "R-CEL-372448", "name": "SLC25A12,13 exchange cytosolic L-Glu for mitochondrial matrix L-Asp", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29404", "species_113553" ], "products": [ "species_29448", "species_113552" ], "modifiers": [ [ "species_10518286", "catalyst" ] ], "additional_components": [ "Q21153", "WBGene00019326" ] }, "reaction_10503201": { "compartment": "compartment_5460", "id": "reaction_10503201", "reactome": "R-CEL-70596", "name": "GOT2 dimer deaminates L-Asp", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113594", "species_113553" ], "products": [ "species_113587", "species_113552" ], "modifiers": [ [ "species_10503198", "catalyst" ] ], "additional_components": [ "Q17994", "WBGene00015778" ] }, "reaction_10557141": { "compartment": "compartment_876", "id": "reaction_10557141", "reactome": "R-CEL-5693783", "name": "NAALADases hydrolyse NAAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5693762" ], "products": [ "species_29404", "species_5693772" ], "modifiers": [ [ "species_10557138", "catalyst" ] ], "additional_components": [ "P91406", "WBGene00020082", "Q93332", "WBGene00007954" ] }, "reaction_10503190": { "compartment": "compartment_70101", "id": "reaction_10503190", "reactome": "R-CEL-70592", "name": "PXLP-K259-GOT1 dimer deaminates L-Asp", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29406", "species_29448" ], "products": [ "species_29404", "species_76213" ], "modifiers": [ [ "species_10503175", "catalyst" ] ], "additional_components": [ "Q22067", "WBGene00020146" ] }, "reaction_10559320": { "compartment": "compartment_70101", "id": "reaction_10559320", "reactome": "R-CEL-6797627", "name": "ASPG hydrolyses L-Asn to L-Asp", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_29642" ], "products": [ "species_29448", "species_29382" ], "modifiers": [ [ "species_10559317", "catalyst" ] ], "additional_components": [ "WBGene00007756" ] }, "reaction_10503178": { "compartment": "compartment_70101", "id": "reaction_10503178", "reactome": "R-CEL-70581", "name": "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29404", "species_76213" ], "products": [ "species_29406", "species_29448" ], "modifiers": [ [ "species_10503175", "catalyst" ] ], "additional_components": [ "Q22067", "WBGene00020146" ] }, "reaction_10503296": { "compartment": "compartment_5460", "id": "reaction_10503296", "reactome": "R-CEL-70666", "name": "glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_31339", "species_113552" ], "products": [ "species_113594", "species_113585" ], "modifiers": [ [ "species_10503281", "catalyst" ] ], "additional_components": [ "Q18040", "WBGene00015814" ] }, "reaction_10503265": { "compartment": "compartment_5460", "id": "reaction_10503265", "reactome": "R-CEL-70613", "name": "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT2]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113587", "species_113552" ], "products": [ "species_113594", "species_113553" ], "modifiers": [ [ "species_10503198", "catalyst" ] ], "additional_components": [ "Q17994", "WBGene00015778" ] }, "reaction_10503203": { "compartment": "compartment_5460", "id": "reaction_10503203", "reactome": "R-CEL-70600", "name": "glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ [GLUD1]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113552", "species_113521", "species_517495" ], "products": [ "species_517496", "species_113594", "species_113529", "species_113561" ], "modifiers": [ [ "species_10503185", "catalyst" ], [ "species_113581", "catalyst" ], [ "species_113573", "inhibitor" ] ], "additional_components": [ "species_29360", "species_29366", "species_29364", "species_73473", "Q23621", "WBGene00014095" ] }, "reaction_10503188": { "compartment": "compartment_5460", "id": "reaction_10503188", "reactome": "R-CEL-70589", "name": "alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ [GLUD1]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_517496", "species_113594", "species_113529", "species_113561" ], "products": [ "species_113552", "species_113521", "species_517495" ], "modifiers": [ [ "species_10503185", "catalyst" ], [ "species_113581", "catalyst" ], [ "species_113573", "inhibitor" ] ], "additional_components": [ "species_29364", "species_73473", "species_29360", "species_29366", "Q23621", "WBGene00014095" ] }, "reaction_10558039": { "compartment": "compartment_70101", "id": "reaction_10558039", "reactome": "R-CEL-6783955", "name": "PYCRL decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_35305", "species_29364" ], "products": [ "species_29366", "species_113538" ], "modifiers": [ [ "species_10558036", "catalyst" ] ], "additional_components": [ "Q21544", "WBGene00010924", "Q20848", "WBGene00018904" ] }, "reaction_10527197": { "compartment": "compartment_5460", "id": "reaction_10527197", "reactome": "R-CEL-508040", "name": "glutamate + ATP + NADPH + H+ => L-glutamate gamma-semialdehyde + NADP+ + ADP + orthophosphate [P5CS]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113529", "species_113593", "species_113600", "species_113552" ], "products": [ "species_113548", "species_113581", "species_31339", "species_113563" ], "modifiers": [ [ "species_10527194", "catalyst" ] ], "additional_components": [ "P54889", "WBGene00011938" ] }, "reaction_10558028": { "compartment": "compartment_5460", "id": "reaction_10558028", "reactome": "R-CEL-6783939", "name": "PYCR2 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113529", "species_113590", "species_29362" ], "products": [ "species_113526", "species_379717" ], "modifiers": [ [ "species_10558025", "catalyst" ] ], "additional_components": [ "Q20848", "WBGene00018904", "Q21544", "WBGene00010924" ] }, "reaction_10503294": { "compartment": "compartment_5460", "id": "reaction_10503294", "reactome": "R-CEL-70664", "name": "PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113529", "species_113590", "species_29362" ], "products": [ "species_113526", "species_379717" ], "modifiers": [ [ "species_10503291", "catalyst" ] ], "additional_components": [ "Q21544", "WBGene00010924" ] }, "reaction_10528415": { "compartment": "compartment_70101", "id": "reaction_10528415", "reactome": "R-CEL-893616", "name": "glutamine + pyruvate => 2-oxoglutaramate + alanine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29398", "species_29472" ], "products": [ "species_29432", "species_893598" ], "modifiers": [ [ "species_10528406", "catalyst" ] ], "additional_components": [ "Q9XX97", "WBGene00009232", "Q8MP09", "WBGene00010984" ] }, "reaction_10516466": { "compartment": "compartment_70101", "id": "reaction_10516466", "reactome": "R-CEL-209924", "name": "Dopa is decarboxylated to dopamine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_209849" ], "products": [ "species_113528", "species_159362" ], "modifiers": [ [ "species_10516426", "catalyst" ] ], "additional_components": [ "O45137", "WBGene00000239" ] }, "reaction_10516446": { "compartment": "compartment_70101", "id": "reaction_10516446", "reactome": "R-CEL-209903", "name": "Noradrenaline is converted to adrenaline", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_209789", "species_71284" ], "products": [ "species_70106", "species_71285", "species_209794" ], "modifiers": [ [ "species_10516443", "catalyst" ] ], "additional_components": [ "Q20308", "WBGene00018340", "Q22279", "WBGene00011573", "P34254", "WBGene00015124" ] }, "reaction_10516399": { "compartment": "compartment_70101", "id": "reaction_10516399", "reactome": "R-CEL-209823", "name": "Tyrosine is hydroxylated to dopa", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29870", "species_29368", "species_29506" ], "products": [ "species_209849", "species_71112" ], "modifiers": [ [ "species_10516396", "catalyst" ] ], "additional_components": [ "species_113531", "P90986", "WBGene00000296" ] }, "reaction_10516464": { "compartment": "compartment_984", "id": "reaction_10516464", "reactome": "R-CEL-209921", "name": "Monoiodinated tyrosine can be deiodinated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351627", "species_351639" ], "products": [ "species_352030", "species_351628", "species_209818" ], "modifiers": [ [ "species_10516461", "catalyst" ] ], "additional_components": [ "species_73524", "P34273", "WBGene00015334" ] }, "reaction_10516468": { "compartment": "compartment_984", "id": "reaction_10516468", "reactome": "R-CEL-209925", "name": "DIT and MIT combine to form triiodothyronine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352329", "species_351639" ], "products": [ "species_352331", "species_352036" ], "modifiers": [ [ "species_10516386", "catalyst" ] ], "additional_components": [ "Q23490", "WBGene00022743", "P91060", "WBGene00015841", "Q1ENI8", "WBGene00004256", "G5EG78", "WBGene00004257", "Q20616", "WBGene00009897", "H2KZ53", "WBGene00017968" ] }, "reaction_10557028": { "compartment": "compartment_876", "id": "reaction_10557028", "reactome": "R-CEL-5693681", "name": "DUOX1,2 reduce O2 to H2O2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_351627", "species_352327" ], "products": [ "species_351628", "species_351629" ], "modifiers": [ [ "species_10557025", "catalyst" ] ], "additional_components": [ "O01795", "WBGene00018771", "O61213", "WBGene00000253" ] }, "reaction_10516389": { "compartment": "compartment_984", "id": "reaction_10516389", "reactome": "R-CEL-209815", "name": "Tyrosine is monoiodinated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351630", "species_352030" ], "products": [ "species_622410", "species_351639" ], "modifiers": [ [ "species_10516386", "catalyst" ] ], "additional_components": [ "Q23490", "WBGene00022743", "P91060", "WBGene00015841", "Q1ENI8", "WBGene00004256", "G5EG78", "WBGene00004257", "Q20616", "WBGene00009897", "H2KZ53", "WBGene00017968" ] }, "reaction_10516454": { "compartment": "compartment_876", "id": "reaction_10516454", "reactome": "R-CEL-209910", "name": "Iodide is taken up by thyroid epithelial cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_209818", "species_74113" ], "products": [ "species_209785", "species_83910" ], "modifiers": [ [ "species_10516451", "catalyst" ] ], "additional_components": [ "WBGene00018716" ] }, "reaction_10516470": { "compartment": "compartment_984", "id": "reaction_10516470", "reactome": "R-CEL-209960", "name": "Diiodinated tyrosine can be deiodinated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351627", "species_352329" ], "products": [ "species_352030", "species_351628", "species_209818" ], "modifiers": [ [ "species_10516461", "catalyst" ] ], "additional_components": [ "species_73524", "P34273", "WBGene00015334" ] }, "reaction_10516472": { "compartment": "compartment_984", "id": "reaction_10516472", "reactome": "R-CEL-209973", "name": "Tyrosine is diiodinated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_351627", "species_352030", "species_209818", "species_351629" ], "products": [ "species_109276", "species_352329", "species_351628" ], "modifiers": [ [ "species_10516386", "catalyst" ] ], "additional_components": [ "Q23490", "WBGene00022743", "P91060", "WBGene00015841", "Q1ENI8", "WBGene00004256", "G5EG78", "WBGene00004257", "Q20616", "WBGene00009897", "H2KZ53", "WBGene00017968" ] }, "reaction_10517997": { "compartment": "compartment_984", "id": "reaction_10517997", "reactome": "R-CEL-350901", "name": "Iodide is organified", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_351627", "species_209818", "species_351629" ], "products": [ "species_109276", "species_351630", "species_351628" ], "modifiers": [ [ "species_10516386", "catalyst" ] ], "additional_components": [ "Q23490", "WBGene00022743", "P91060", "WBGene00015841", "Q1ENI8", "WBGene00004256", "G5EG78", "WBGene00004257", "Q20616", "WBGene00009897", "H2KZ53", "WBGene00017968" ] }, "reaction_10516413": { "compartment": "compartment_984", "id": "reaction_10516413", "reactome": "R-CEL-209840", "name": "Two DITs combine to form thyroxine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352329" ], "products": [ "species_352326", "species_352036" ], "modifiers": [ [ "species_10516386", "catalyst" ] ], "additional_components": [ "Q23490", "WBGene00022743", "P91060", "WBGene00015841", "Q1ENI8", "WBGene00004256", "G5EG78", "WBGene00004257", "Q20616", "WBGene00009897", "H2KZ53", "WBGene00017968" ] }, "reaction_10567841": { "compartment": "compartment_5668575", "id": "reaction_10567841", "reactome": "R-CEL-8878581", "name": "TYRP1 oxidises DHICA to IQCA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5662670", "species_5668566" ], "products": [ "species_8878586", "species_5668574" ], "modifiers": [ [ "species_10567838", "catalyst" ] ], "additional_components": [ "O01497", "WBGene00016419", "O76708", "WBGene00021553", "P34269", "WBGene00015332", "Q19673", "WBGene00009001", "Q95XC6", "WBGene00022231", "Q9XUS8", "WBGene00010661" ] }, "reaction_10554582": { "compartment": "compartment_5668575", "id": "reaction_10554582", "reactome": "R-CEL-5662662", "name": "Tyrosinase oxidises tyrosine to dopaquinone", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5668573", "species_5668567" ], "products": [ "species_5668577", "species_5662695" ], "modifiers": [ [ "species_10554579", "catalyst" ] ], "additional_components": [ "P34269", "WBGene00015332", "species_209799" ] }, "reaction_10554584": { "compartment": "compartment_5668572", "id": "reaction_10554584", "reactome": "R-CEL-5662692", "name": "Dopa is oxidized to dopaquinone by TYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5668568", "species_5668566" ], "products": [ "species_5668574", "species_5662695" ], "modifiers": [ [ "species_10554579", "catalyst" ] ], "additional_components": [ "P34269", "WBGene00015332", "species_209799" ] }, "reaction_10554586": { "compartment": "compartment_5668572", "id": "reaction_10554586", "reactome": "R-CEL-5663050", "name": "DHI and DHICA polymerise forming eumelanin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5662708", "species_5662695" ], "products": [ "species_5668568", "species_5662678" ], "modifiers": [ [ "species_10554579", "catalyst" ] ], "additional_components": [ "species_5662670", "CHEBI:27404", "species_5662670", "CHEBI:27404", "P34269", "WBGene00015332", "species_209799" ] }, "reaction_10554575": { "compartment": "compartment_5668572", "id": "reaction_10554575", "reactome": "R-CEL-5662660", "name": "Dopachrome is transformed to DHICA by DCT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5662665" ], "products": [ "species_5662670" ], "modifiers": [ [ "species_10554572", "catalyst" ] ], "additional_components": [ "Q95XC6", "WBGene00022231", "O76708", "WBGene00021553", "P34269", "WBGene00015332", "Q9XUS8", "WBGene00010661", "O01497", "WBGene00016419", "Q19673", "WBGene00009001", "species_216785" ] }, "reaction_10559330": { "compartment": "compartment_5460", "id": "reaction_10559330", "reactome": "R-CEL-6797653", "name": "DMGDH:FAD oxidatively demethylates DMGLY to SARC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6797923", "species_113521" ], "products": [ "species_6797917", "species_6797920" ], "modifiers": [ [ "species_10559327", "catalyst" ] ], "additional_components": [ "A0A486WWC6", "WBGene00021355", "species_113596" ] }, "reaction_10559333": { "compartment": "compartment_5460", "id": "reaction_10559333", "reactome": "R-CEL-6797955", "name": "ALDH7A1 oxidises BETALD to BET", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113526", "species_6798194", "species_113521" ], "products": [ "species_6798202", "species_29362" ], "modifiers": [ [ "species_10503536", "catalyst" ] ], "additional_components": [ "WBGene00000115" ] }, "reaction_10559341": { "compartment": "compartment_5460", "id": "reaction_10559341", "reactome": "R-CEL-6797961", "name": "CHDH oxidises Cho to BETALD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113596", "species_6798162" ], "products": [ "species_6798194", "species_31649" ], "modifiers": [ [ "species_10559338", "catalyst" ] ], "additional_components": [ "WBGene00007917" ] }, "reaction_10569987": { "compartment": "compartment_5460", "id": "reaction_10569987", "reactome": "R-CEL-8955817", "name": "PRODH2 oxidises HPRO to 1PYR-5COOH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113597", "species_6784215" ], "products": [ "species_113590", "species_164934", "species_113521" ], "modifiers": [ [ "species_10558041", "catalyst" ] ], "additional_components": [ "WBGene00007197" ] }, "reaction_10503304": { "compartment": "compartment_5460", "id": "reaction_10503304", "reactome": "R-CEL-70670", "name": "PRODH oxidises L-Pro to 1PYR-5COOH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113597", "species_379717" ], "products": [ "species_113529", "species_113590", "species_164934" ], "modifiers": [ [ "species_10503301", "catalyst" ] ], "additional_components": [ "WBGene00007197" ] }, "reaction_10520736": { "compartment": "compartment_17951", "id": "reaction_10520736", "reactome": "R-CEL-389862", "name": "Conversion of glyoxylate to oxalate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113535", "species_141343", "species_389678" ], "products": [ "species_389819", "species_113575" ], "modifiers": [ [ "species_10520730", "catalyst" ] ], "additional_components": [ "B1GRK5", "WBGene00018286", "species_73524" ] }, "reaction_10559137": { "compartment": "compartment_5460", "id": "reaction_10559137", "reactome": "R-CEL-6793591", "name": "LIAS:2(4Fe-4S) transforms octanoyl-K107-GCSH to lipoyl-K107-GCSH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6793610", "species_2162265", "species_10559127" ], "products": [ "species_379705", "species_10557165", "species_6793613" ], "modifiers": [ [ "species_10559134", "catalyst" ] ], "additional_components": [ "WBGene00009918", "WBGene00009918", "CHEBI:49883", "Q21452", "WBGene00010809" ] }, "reaction_10558048": { "compartment": "compartment_5460", "id": "reaction_10558048", "reactome": "R-CEL-6784224", "name": "PRODH2:FAD dimer dehydrogenates HPRO to 1-pyrroline-3-hydroxy-5-carboxylate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6784215" ], "products": [ "species_6784241" ], "modifiers": [ [ "species_10558045", "catalyst" ] ], "additional_components": [ "O45228", "WBGene00007197", "species_113596" ] }, "reaction_10520721": { "compartment": "compartment_17951", "id": "reaction_10520721", "reactome": "R-CEL-389821", "name": "glycine + O2 => glyoxylate + H2O2 + NH4+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113535", "species_141343", "species_193446" ], "products": [ "species_389678", "species_389843", "species_113575" ], "modifiers": [ [ "species_10520718", "catalyst" ] ], "additional_components": [ "species_113596", "Q19564", "WBGene00017565", "Q95XG9", "WBGene00022076", "O01739", "WBGene00017648", "O45307", "WBGene00008127" ] }, "reaction_10559104": { "compartment": "compartment_5460", "id": "reaction_10559104", "reactome": "R-CEL-6792572", "name": "LIPT1 transfers lipoyl group from lipoyl-GCSH to DHs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10557165", "species_10559088" ], "products": [ "species_10557167", "species_10559096" ], "modifiers": [ [ "species_10559101", "catalyst" ] ], "additional_components": [ "WBGene00009918", "CHEBI:17460", "O45148", "WBGene00020950", "O61199", "WBGene00020679", "species_8878387", "O17953", "WBGene00010794", "species_113596", "Q93619", "WBGene00006518", "O45924", "WBGene00012713", "Q23571", "WBGene00014054", "P52899", "WBGene00011510", "O44451", "WBGene00015413", "Q19749", "WBGene00009082", "Q23629", "WBGene00014098", "WBGene00009918", "Q23571", "WBGene00014054", "Q93619", "WBGene00006518", "species_8878387", "O45924", "WBGene00012713", "O17953", "WBGene00010794", "species_113596", "Q23629", "WBGene00014098", "O61199", "WBGene00020679", "CHEBI:17460", "O45148", "WBGene00020950", "P52899", "WBGene00011510", "O44451", "WBGene00015413", "Q19749", "WBGene00009082", "WBGene00001590" ] }, "reaction_10558051": { "compartment": "compartment_5460", "id": "reaction_10558051", "reactome": "R-CEL-6784393", "name": "PXLP-K279-GOT2 dimer transaminates 4-OH-L-glutamate to 4-hydroxy-2-oxoglutarate (HOG)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6784236", "species_113587" ], "products": [ "species_6784229", "species_113553" ], "modifiers": [ [ "species_10503198", "catalyst" ] ], "additional_components": [ "Q17994", "WBGene00015778" ] }, "reaction_10520662": { "compartment": "compartment_17951", "id": "reaction_10520662", "reactome": "R-CEL-389684", "name": "glyoxylate + alanine => glycine + pyruvate [peroxisome]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_389678", "species_389664" ], "products": [ "species_389680", "species_193446" ], "modifiers": [ [ "species_10520659", "catalyst" ] ], "additional_components": [ "Q94055", "WBGene00011767" ] }, "reaction_10563702": { "compartment": "compartment_17951", "id": "reaction_10563702", "reactome": "R-CEL-6810076", "name": "DDO oxidizes D-Asp to OA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113535", "species_141343", "species_6810061" ], "products": [ "species_113575", "species_389843", "species_6810070" ], "modifiers": [ [ "species_10563699", "catalyst" ] ], "additional_components": [ "Q95XG9", "WBGene00022076", "species_113596" ] }, "reaction_10528441": { "compartment": "compartment_5460", "id": "reaction_10528441", "reactome": "R-CEL-904864", "name": "Mitochondrial AGXT2 tetramer transaminates glyoxylate and alanine to glycine and pyruvate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_904849", "species_379697" ], "products": [ "species_159549", "species_113557" ], "modifiers": [ [ "species_10528438", "catalyst" ] ], "additional_components": [ "O02158", "WBGene00020382" ] }, "reaction_10557190": { "compartment": "compartment_5460", "id": "reaction_10557190", "reactome": "R-CEL-5693977", "name": "AMT transfers NH2CH2 from GCSH:SAMDLL to THF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200671", "species_10557169" ], "products": [ "species_10557182", "species_5693978", "species_5693984" ], "modifiers": [ [ "species_10557187", "catalyst" ] ], "additional_components": [ "CHEBI:14949", "Q20634", "WBGene00009918", "CHEBI:50746", "Q20634", "WBGene00009918", "WBGene00017765" ] }, "reaction_10557195": { "compartment": "compartment_5460", "id": "reaction_10557195", "reactome": "R-CEL-5694018", "name": "DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10557182", "species_113526" ], "products": [ "species_10557165", "species_113529", "species_29362" ], "modifiers": [ [ "species_10557192", "catalyst" ] ], "additional_components": [ "CHEBI:50746", "Q20634", "WBGene00009918", "WBGene00009918", "O17953", "WBGene00010794", "species_113596" ] }, "reaction_10557180": { "compartment": "compartment_5460", "id": "reaction_10557180", "reactome": "R-CEL-5693967", "name": "PXLP-K754-GLDC dimer decarboxylates Gly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_159549", "species_10557165" ], "products": [ "species_10557169", "species_29376" ], "modifiers": [ [ "species_10557177", "catalyst" ] ], "additional_components": [ "WBGene00009918", "CHEBI:14949", "Q20634", "WBGene00009918", "Q21962", "WBGene00020022" ] }, "reaction_10520733": { "compartment": "compartment_17951", "id": "reaction_10520733", "reactome": "R-CEL-389842", "name": "HAO1 tetramer oxidizes glycolate to glyoxylate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113535", "species_389822" ], "products": [ "species_389678", "species_113575" ], "modifiers": [ [ "species_10520730", "catalyst" ] ], "additional_components": [ "B1GRK5", "WBGene00018286", "species_73524" ] }, "reaction_10503876": { "compartment": "compartment_70101", "id": "reaction_10503876", "reactome": "R-CEL-71249", "name": "SHMT1 tetramer cleaves HTMLYS to yield TEABL and Gly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_31503" ], "products": [ "species_31311", "species_29424" ], "modifiers": [ [ "species_10503873", "catalyst" ] ], "additional_components": [ "P50432", "WBGene00003214" ] }, "reaction_10503865": { "compartment": "compartment_5460", "id": "reaction_10503865", "reactome": "R-CEL-71241", "name": "TMLHE dimer dioxygenates TMLYS and 2OG to form HTMLYS and SUCCA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113533", "species_113594", "species_35139" ], "products": [ "species_113546", "species_113536", "species_29376" ], "modifiers": [ [ "species_10503862", "catalyst" ] ], "additional_components": [ "Q21526", "WBGene00001523", "species_198836", "species_113531" ] }, "reaction_10503886": { "compartment": "compartment_70101", "id": "reaction_10503886", "reactome": "R-CEL-71260", "name": "ALDH9A1 tetramer dehydrogenates TEABL to form TEABT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_31311", "species_29356", "species_29360" ], "products": [ "species_70106", "species_31369", "species_73473" ], "modifiers": [ [ "species_10503883", "catalyst" ] ], "additional_components": [ "Q20352", "WBGene00000117" ] }, "reaction_10534694": { "compartment": "compartment_5460", "id": "reaction_10534694", "reactome": "R-CEL-1475028", "name": "Carbonic anhydrase dehydrates bicarbonate (mitochondria)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29896", "species_113529" ], "products": [ "species_113521", "species_29376" ], "modifiers": [ [ "species_10534691", "catalyst" ] ], "additional_components": [ "species_216785", "O02637", "WBGene00000284", "Q10462", "WBGene00000283", "Q21614", "WBGene00000282", "Q27504", "WBGene00000281" ] }, "reaction_10534663": { "compartment": "compartment_70101", "id": "reaction_10534663", "reactome": "R-CEL-1475022", "name": "Carbonic anhydrase dehydrates bicarbonate (cytosol)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_111627" ], "products": [ "species_29356", "species_113528" ], "modifiers": [ [ "species_10534660", "catalyst" ] ], "additional_components": [ "O02637", "WBGene00000284", "Q10462", "WBGene00000283", "Q21614", "WBGene00000282", "Q27504", "WBGene00000281", "species_216785" ] }, "reaction_10534696": { "compartment": "compartment_5460", "id": "reaction_10534696", "reactome": "R-CEL-1475032", "name": "Carbonic anhydrase hydrates carbon dioxide (mitochondria)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113521", "species_29376" ], "products": [ "species_29896", "species_113529" ], "modifiers": [ [ "species_10534691", "catalyst" ] ], "additional_components": [ "species_216785", "O02637", "WBGene00000284", "Q10462", "WBGene00000283", "Q21614", "WBGene00000282", "Q27504", "WBGene00000281" ] }, "reaction_10534665": { "compartment": "compartment_70101", "id": "reaction_10534665", "reactome": "R-CEL-1475026", "name": "Carbonic anhydrase hydrates carbon dioxide (cytosol)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113528" ], "products": [ "species_70106", "species_111627" ], "modifiers": [ [ "species_10534660", "catalyst" ] ], "additional_components": [ "O02637", "WBGene00000284", "Q10462", "WBGene00000283", "Q21614", "WBGene00000282", "Q27504", "WBGene00000281", "species_216785" ] }, "reaction_10537601": { "compartment": "compartment_70101", "id": "reaction_10537601", "reactome": "R-CEL-1855166", "name": "PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_2023943" ], "products": [ "species_29372", "species_994141" ], "modifiers": [ [ "species_10537589", "catalyst" ] ], "additional_components": [ "species_1629736", "species_1629755", "CHEBI:62927", "Q95XC4", "WBGene00022366", "species_114632", "species_266099" ] }, "reaction_10537634": { "compartment": "compartment_70101", "id": "reaction_10537634", "reactome": "R-CEL-1855179", "name": "I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_994141" ], "products": [ "species_29370", "species_1629770" ], "modifiers": [ [ "species_10537631", "catalyst" ] ], "additional_components": [ "WBGene00012466" ] }, "reaction_10537666": { "compartment": "compartment_70101", "id": "reaction_10537666", "reactome": "R-CEL-1855194", "name": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/3 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1629740" ], "products": [ "species_1629732", "species_29370" ], "modifiers": [ [ "species_10537575", "catalyst" ] ], "additional_components": [ "Q9BKX8", "WBGene00021260", "O02167", "WBGene00021260", "Q93644", "WBGene00021260" ] }, "reaction_10537764": { "compartment": "compartment_70101", "id": "reaction_10537764", "reactome": "R-CEL-1855227", "name": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1629770" ], "products": [ "species_1629765", "species_29370" ], "modifiers": [ [ "species_10537575", "catalyst" ] ], "additional_components": [ "Q9BKX8", "WBGene00021260", "O02167", "WBGene00021260", "Q93644", "WBGene00021260" ] }, "reaction_10541476": { "compartment": "compartment_70101", "id": "reaction_10541476", "reactome": "R-CEL-2023971", "name": "1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_2023974" ], "products": [ "species_29372", "species_1629770" ], "modifiers": [ [ "species_10537595", "catalyst" ] ], "additional_components": [ "species_1629740", "CHEBI:62922", "species_114632", "Q95XC4", "WBGene00022366", "species_266099" ] }, "reaction_10537669": { "compartment": "compartment_70101", "id": "reaction_10537669", "reactome": "R-CEL-1855198", "name": "5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1629765", "species_29356" ], "products": [ "species_29372", "species_1629770" ], "modifiers": [ [ "species_10537595", "catalyst" ] ], "additional_components": [ "species_114632", "Q95XC4", "WBGene00022366", "species_266099" ] }, "reaction_10541478": { "compartment": "compartment_70101", "id": "reaction_10541478", "reactome": "R-CEL-2023973", "name": "(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2023968", "species_29356" ], "products": [ "species_29372", "species_2023974" ], "modifiers": [ [ "species_10537595", "catalyst" ] ], "additional_components": [ "species_1629732", "CHEBI:62924", "species_1629740", "CHEBI:62922", "species_114632", "Q95XC4", "WBGene00022366", "species_266099" ] }, "reaction_10537578": { "compartment": "compartment_70101", "id": "reaction_10537578", "reactome": "R-CEL-1855158", "name": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1629765", "species_113592" ], "products": [ "species_29370", "species_1629759" ], "modifiers": [ [ "species_10537575", "catalyst" ] ], "additional_components": [ "Q9BKX8", "WBGene00021260", "O02167", "WBGene00021260", "Q93644", "WBGene00021260" ] }, "reaction_10537652": { "compartment": "compartment_70101", "id": "reaction_10537652", "reactome": "R-CEL-1855182", "name": "5-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by PPIP5K1/2 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1629765", "species_113592" ], "products": [ "species_1629732", "species_29370" ], "modifiers": [ [ "species_10537649", "catalyst" ] ], "additional_components": [ "P91309", "WBGene00018508" ] }, "reaction_10537758": { "compartment": "compartment_70101", "id": "reaction_10537758", "reactome": "R-CEL-1855223", "name": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/3 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_994141" ], "products": [ "species_29370", "species_1629755" ], "modifiers": [ [ "species_10537575", "catalyst" ] ], "additional_components": [ "Q9BKX8", "WBGene00021260", "O02167", "WBGene00021260", "Q93644", "WBGene00021260" ] }, "reaction_10537726": { "compartment": "compartment_70101", "id": "reaction_10537726", "reactome": "R-CEL-1855216", "name": "IP6 is phosphorylated to 1-PP-IP5 by PPIP5K1/2 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1629770" ], "products": [ "species_29370", "species_1629740" ], "modifiers": [ [ "species_10537649", "catalyst" ] ], "additional_components": [ "P91309", "WBGene00018508" ] }, "reaction_10537598": { "compartment": "compartment_70101", "id": "reaction_10537598", "reactome": "R-CEL-1855165", "name": "(PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2023968", "species_29356" ], "products": [ "species_1629765", "species_29372" ], "modifiers": [ [ "species_10537595", "catalyst" ] ], "additional_components": [ "species_1629732", "CHEBI:62924", "species_114632", "Q95XC4", "WBGene00022366", "species_266099" ] }, "reaction_10537663": { "compartment": "compartment_70101", "id": "reaction_10537663", "reactome": "R-CEL-1855193", "name": "1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1629736" ], "products": [ "species_29370", "species_1629738" ], "modifiers": [ [ "species_10537575", "catalyst" ] ], "additional_components": [ "Q9BKX8", "WBGene00021260", "O02167", "WBGene00021260", "Q93644", "WBGene00021260" ] }, "reaction_10555333": { "compartment": "compartment_70101", "id": "reaction_10555333", "reactome": "R-CEL-5678327", "name": "MIOX oxidises Ins to GlcA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_426910" ], "products": [ "species_29356", "species_70106", "species_2162232" ], "modifiers": [ [ "species_10555330", "catalyst" ] ], "additional_components": [ "Q65CM5", "WBGene00016920", "species_113531" ] }, "reaction_10537637": { "compartment": "compartment_70101", "id": "reaction_10537637", "reactome": "R-CEL-1855180", "name": "I(1,3,4)P3 is dephosphorylated to I(1,3)P2 by INPP4A/B in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_994123" ], "products": [ "species_29372", "species_1629769" ], "modifiers": [ [ "species_10537307", "catalyst" ] ], "additional_components": [ "Q21623", "WBGene00010975" ] }, "reaction_10537606": { "compartment": "compartment_70101", "id": "reaction_10537606", "reactome": "R-CEL-1855174", "name": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_114520" ], "products": [ "species_29372", "species_1629739" ], "modifiers": [ [ "species_10537603", "catalyst" ] ], "additional_components": [ "O17590", "WBGene00007620", "P34370", "WBGene00086546", "G5ECL2", "WBGene00006763" ] }, "reaction_10537686": { "compartment": "compartment_70101", "id": "reaction_10537686", "reactome": "R-CEL-1855210", "name": "I3P is dephosphorylated to Ins by IMPA1/2 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1629731" ], "products": [ "species_29372", "species_426910" ], "modifiers": [ [ "species_10537530", "catalyst" ] ], "additional_components": [ "species_114632", "Q19420", "WBGene00008765" ] }, "reaction_10537672": { "compartment": "compartment_70101", "id": "reaction_10537672", "reactome": "R-CEL-1855202", "name": "I(3,4)P2 is dephosphorylated to I3P by INPP4A/B in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1629746" ], "products": [ "species_29372", "species_1629731" ], "modifiers": [ [ "species_10537307", "catalyst" ] ], "additional_components": [ "Q21623", "WBGene00010975" ] }, "reaction_10537689": { "compartment": "compartment_70101", "id": "reaction_10537689", "reactome": "R-CEL-1855211", "name": "I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1629753" ], "products": [ "species_29372", "species_426910" ], "modifiers": [ [ "species_10537530", "catalyst" ] ], "additional_components": [ "species_114632", "Q19420", "WBGene00008765" ] }, "reaction_10537755": { "compartment": "compartment_876", "id": "reaction_10537755", "reactome": "R-CEL-1855222", "name": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_114520" ], "products": [ "species_29372", "species_1629739" ], "modifiers": [ [ "species_10537752", "catalyst" ] ], "additional_components": [ "Q17848", "WBGene00002146", "O17590", "WBGene00007620" ] }, "reaction_10537533": { "compartment": "compartment_70101", "id": "reaction_10537533", "reactome": "R-CEL-1855154", "name": "I1P is dephosphorylated to Ins by IMPA1/2 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_870330" ], "products": [ "species_29372", "species_426910" ], "modifiers": [ [ "species_10537530", "catalyst" ] ], "additional_components": [ "species_114632", "Q19420", "WBGene00008765" ] }, "reaction_10537629": { "compartment": "compartment_70101", "id": "reaction_10537629", "reactome": "R-CEL-1855178", "name": "Glc6P is isomerised to I3P by ISYNA1 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1629756" ], "products": [ "species_1629731" ], "modifiers": [ [ "species_10537626", "catalyst" ] ], "additional_components": [ "species_29360", "G5ED01", "WBGene00012148" ] }, "reaction_10520816": { "compartment": "compartment_17951", "id": "reaction_10520816", "reactome": "R-CEL-390425", "name": "FAR1 reduces PalmCoA to HXOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_200993" ], "products": [ "species_29366", "species_8848577", "species_76194" ], "modifiers": [ [ "species_10520813", "catalyst" ] ], "additional_components": [ "WBGene00022200" ] }, "reaction_10564721": { "compartment": "compartment_12045", "id": "reaction_10564721", "reactome": "R-CEL-8848582", "name": "AWAT2 transfers PALM from PALM-CoA to HXOL, forming palmityl palmitate ester", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8848577", "species_200993" ], "products": [ "species_8848499", "species_76194" ], "modifiers": [ [ "species_10557641", "catalyst" ] ], "additional_components": [ "O01881", "WBGene00021818", "Q23067", "WBGene00020910", "Q9N4S3", "WBGene00021818", "Q9XUW0", "WBGene00010296" ] }, "reaction_10564724": { "compartment": "compartment_12045", "id": "reaction_10564724", "reactome": "R-CEL-8848585", "name": "AWAT2 transfers PALM from PALM-CoA to atROL, forming atR-PALM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200993", "species_30209" ], "products": [ "species_76194", "species_2534407" ], "modifiers": [ [ "species_10557641", "catalyst" ] ], "additional_components": [ "O01881", "WBGene00021818", "Q23067", "WBGene00020910", "Q9N4S3", "WBGene00021818", "Q9XUW0", "WBGene00010296" ] }, "reaction_10557631": { "compartment": "compartment_12045", "id": "reaction_10557631", "reactome": "R-CEL-5696424", "name": "AWAT1 transfers acyl group from acyl-CoA to ARACOH, forming wax esters", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_192172", "species_5696426" ], "products": [ "species_5696412", "species_162743" ], "modifiers": [ [ "species_10557628", "catalyst" ] ], "additional_components": [ "O01881", "WBGene00021818", "Q23067", "WBGene00020910", "Q9N4S3", "WBGene00021818", "Q9XUW0", "WBGene00010296" ] }, "reaction_10520819": { "compartment": "compartment_17951", "id": "reaction_10520819", "reactome": "R-CEL-390427", "name": "1-palmitoylglycerone phosphate + hexadecanol => O-hexadecylglycerone phosphate + palmitate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_390440", "species_390419" ], "products": [ "species_390409", "species_390435" ], "modifiers": [ [ "species_10507473", "catalyst" ] ], "additional_components": [ "G5EFP8", "WBGene00012911", "species_113596", "O45218", "WBGene00000081" ] }, "reaction_10507476": { "compartment": "compartment_17951", "id": "reaction_10507476", "reactome": "R-CEL-75879", "name": "palmitoyl-CoA + DHAP => 1-palmitoylglycerone phosphate + CoASH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_390426", "species_390404" ], "products": [ "species_193514", "species_390419" ], "modifiers": [ [ "species_10507473", "catalyst" ] ], "additional_components": [ "G5EFP8", "WBGene00012911", "species_113596", "O45218", "WBGene00000081" ] }, "reaction_10507484": { "compartment": "compartment_70101", "id": "reaction_10507484", "reactome": "R-CEL-75883", "name": "DHRS7B reduces GO3P to HXDG3P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_75973", "species_29364" ], "products": [ "species_29366", "species_390422" ], "modifiers": [ [ "species_10507481", "catalyst" ] ], "additional_components": [ "WBGene00000993" ] }, "reaction_10537136": { "compartment": "compartment_12045", "id": "reaction_10537136", "reactome": "R-CEL-1675813", "name": "PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_426639" ], "products": [ "species_29370", "species_1806234" ], "modifiers": [ [ "species_10537133", "catalyst" ] ], "additional_components": [ "O45318", "WBGene00022501", "Q23083", "WBGene00022501", "Q9XW63", "WBGene00013557" ] }, "reaction_10563689": { "compartment": "compartment_70101", "id": "reaction_10563689", "reactome": "R-CEL-6809764", "name": "SBF1 binds MTMR2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10563685", "species_10537108" ], "products": [ "species_10563687" ], "modifiers": [], "additional_components": [ "WBGene00003477", "WBGene00003475", "Q9N589", "WBGene00003475", "Q9TXP3", "WBGene00003477" ] }, "reaction_10537277": { "compartment": "compartment_12045", "id": "reaction_10537277", "reactome": "R-CEL-1676124", "name": "PI4P is dephosphorylated to PI by SACM1L at the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1806234" ], "products": [ "species_29372", "species_426639" ], "modifiers": [ [ "species_10537274", "catalyst" ] ], "additional_components": [ "WBGene00009264" ] }, "reaction_10563692": { "compartment": "compartment_70101", "id": "reaction_10563692", "reactome": "R-CEL-6809777", "name": "PI3P is dephosphorylated to PI by MTMR2:SBF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_5676030" ], "products": [ "species_29372", "species_426639" ], "modifiers": [ [ "species_10563687", "catalyst" ] ], "additional_components": [ "Q9N589", "WBGene00003475", "Q9TXP3", "WBGene00003477" ] }, "reaction_10563695": { "compartment": "compartment_70101", "id": "reaction_10563695", "reactome": "R-CEL-6809778", "name": "PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_6809774" ], "products": [ "species_29372", "species_422529" ], "modifiers": [ [ "species_10563687", "catalyst" ] ], "additional_components": [ "Q9N589", "WBGene00003475", "Q9TXP3", "WBGene00003477" ] }, "reaction_10537328": { "compartment": "compartment_171062", "id": "reaction_10537328", "reactome": "R-CEL-1676206", "name": "PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A at the early endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806180", "species_113592" ], "products": [ "species_29370", "species_1806238" ], "modifiers": [ [ "species_10537178", "catalyst" ] ], "additional_components": [ "G5EDY0", "WBGene00009552", "species_74016", "species_114632" ] }, "reaction_10563680": { "compartment": "compartment_171062", "id": "reaction_10563680", "reactome": "R-CEL-6809720", "name": "PI3P is dephosphorylated to PI by MTM1:MTMR12", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1806200" ], "products": [ "species_29372", "species_1806199" ], "modifiers": [ [ "species_10563671", "catalyst" ] ], "additional_components": [ "Q9N589", "WBGene00003475", "V6CJW9", "WBGene00021683" ] }, "reaction_10537219": { "compartment": "compartment_171062", "id": "reaction_10537219", "reactome": "R-CEL-1675974", "name": "PI is phosphorylated to PI4P by PI4K2A/B at the early endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806199", "species_113592" ], "products": [ "species_1806180", "species_29370" ], "modifiers": [ [ "species_10537098", "catalyst" ] ], "additional_components": [ "O45318", "WBGene00022501", "Q23083", "WBGene00022501" ] }, "reaction_10537286": { "compartment": "compartment_171062", "id": "reaction_10537286", "reactome": "R-CEL-1676141", "name": "PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1806200" ], "products": [ "species_29372", "species_1806199" ], "modifiers": [ [ "species_10537252", "catalyst" ] ], "additional_components": [ "Q9N589", "WBGene00003475", "Q22712", "WBGene00003476" ] }, "reaction_10537255": { "compartment": "compartment_171062", "id": "reaction_10537255", "reactome": "R-CEL-1676105", "name": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1806205" ], "products": [ "species_29372", "species_1806259" ], "modifiers": [ [ "species_10537252", "catalyst" ] ], "additional_components": [ "Q9N589", "WBGene00003475", "Q22712", "WBGene00003476" ] }, "reaction_10563673": { "compartment": "compartment_70101", "id": "reaction_10563673", "reactome": "R-CEL-6809680", "name": "MTMR12 binds MTM1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10563669", "species_10537106" ], "products": [ "species_10563671" ], "modifiers": [], "additional_components": [ "WBGene00021683", "WBGene00003475", "Q9N589", "WBGene00003475", "V6CJW9", "WBGene00021683" ] }, "reaction_10537196": { "compartment": "compartment_171062", "id": "reaction_10537196", "reactome": "R-CEL-1675939", "name": "PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806199", "species_113592" ], "products": [ "species_29370", "species_1806200" ], "modifiers": [ [ "species_10537193", "catalyst" ] ], "additional_components": [ "Q9TXI7", "WBGene00006932", "species_266099", "Q23669", "WBGene00014151", "G5EDY0", "WBGene00009552", "species_74016", "species_114632" ] }, "reaction_10563677": { "compartment": "compartment_70101", "id": "reaction_10563677", "reactome": "R-CEL-6809707", "name": "MTMR12 binds MTMR2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10563669", "species_10537108" ], "products": [ "species_10563675" ], "modifiers": [], "additional_components": [ "WBGene00021683", "WBGene00003475", "Q9N589", "WBGene00003475", "V6CJW9", "WBGene00021683" ] }, "reaction_10537310": { "compartment": "compartment_171062", "id": "reaction_10537310", "reactome": "R-CEL-1676162", "name": "PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1806238" ], "products": [ "species_29372", "species_1806200" ], "modifiers": [ [ "species_10537307", "catalyst" ] ], "additional_components": [ "Q21623", "WBGene00010975" ] }, "reaction_10564974": { "compartment": "compartment_70101", "id": "reaction_10564974", "reactome": "R-CEL-8849969", "name": "PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_8849959" ], "products": [ "species_29372", "species_8849958" ], "modifiers": [ [ "species_10564971", "catalyst" ] ], "additional_components": [ "species_179838", "species_202247", "species_179856", "species_1806200", "species_5334668", "species_6810408", "WBGene00012353" ] }, "reaction_10564261": { "compartment": "compartment_12045", "id": "reaction_10564261", "reactome": "R-CEL-6814254", "name": "PNPLA6 hydrolyzes LysoPtdCho", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_6814253" ], "products": [ "species_1498750", "species_1524021" ], "modifiers": [ [ "species_10564258", "catalyst" ] ], "additional_components": [ "Q21534", "WBGene00022718", "Q02331", "WBGene00022718" ] }, "reaction_10564484": { "compartment": "compartment_876", "id": "reaction_10564484", "reactome": "R-CEL-6814797", "name": "ENPP6 hydrolyzes lysophosphatidylcholine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_2239407" ], "products": [ "species_6814794", "species_6814795" ], "modifiers": [ [ "species_10564481", "catalyst" ] ], "additional_components": [ "O45359", "WBGene00020195", "Q17540", "WBGene00020195", "Q22129", "WBGene00020195" ] }, "reaction_10564134": { "compartment": "compartment_876", "id": "reaction_10564134", "reactome": "R-CEL-6813740", "name": "GDE1 hydrolyzes GroPIns", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_6813734" ], "products": [ "species_426910", "species_76114" ], "modifiers": [ [ "species_10564131", "catalyst" ] ], "additional_components": [ "WBGene00020446" ] }, "reaction_10542310": { "compartment": "compartment_17957", "id": "reaction_10542310", "reactome": "R-CEL-2046092", "name": "Desaturation of dihomo-gamma-lenolenoyl-CoA to arachidonoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_194697", "species_2046045" ], "products": [ "species_194653", "species_113519", "species_2046053" ], "modifiers": [ [ "species_10542305", "catalyst" ] ], "additional_components": [ "G5EG11", "WBGene00001396", "Q23221", "WBGene00001395" ] }, "reaction_10542312": { "compartment": "compartment_12045", "id": "reaction_10542312", "reactome": "R-CEL-2046093", "name": "Translocation of tetracosapentaenoyl-CoA to peroxisomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2046050", "species_211579" ], "products": [ "species_5228339", "species_2046055", "species_211606" ], "modifiers": [ [ "species_10520379", "catalyst" ] ], "additional_components": [ "WBGene00004061" ] }, "reaction_10542314": { "compartment": "compartment_17957", "id": "reaction_10542314", "reactome": "R-CEL-2046094", "name": "Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2046066", "species_2046042", "species_113601" ], "products": [ "species_113519", "species_113564", "species_162743", "species_159751", "species_2046045" ], "modifiers": [ [ "species_10527261", "catalyst" ] ], "additional_components": [ "WBGene00001241" ] }, "reaction_10542316": { "compartment": "compartment_12045", "id": "reaction_10542316", "reactome": "R-CEL-2046096", "name": "Desaturation of Linoleoyl-CoA to gamma-linolenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_194697", "species_2046063" ], "products": [ "species_194653", "species_113519", "species_2046042" ], "modifiers": [ [ "species_10542288", "catalyst" ] ], "additional_components": [ "WBGene00001395" ] }, "reaction_10542318": { "compartment": "compartment_17957", "id": "reaction_10542318", "reactome": "R-CEL-2046097", "name": "Desaturation of tetracosatetraenoyl-CoA to tetracosapentaenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_2046048", "species_194697" ], "products": [ "species_194653", "species_113519", "species_2046050" ], "modifiers": [ [ "species_10542288", "catalyst" ] ], "additional_components": [ "WBGene00001395" ] }, "reaction_10557520": { "compartment": "compartment_5460", "id": "reaction_10557520", "reactome": "R-CEL-5695989", "name": "ACAD11 dehydrogenates BH-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113596", "species_5695963" ], "products": [ "species_5695976", "species_31649" ], "modifiers": [ [ "species_10557517", "catalyst" ] ], "additional_components": [ "WBGene00019599" ] }, "reaction_10556512": { "compartment": "compartment_70101", "id": "reaction_10556512", "reactome": "R-CEL-5690043", "name": "Cytosolic ACOTs hydrolyse MCFA-CoA, LCFA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_5690044" ], "products": [ "species_5690064", "species_76194" ], "modifiers": [ [ "species_10556509", "catalyst" ] ], "additional_components": [ "species_5690542", "species_164991", "species_5690531", "species_174602", "O45003", "WBGene00020989", "Q9GYN3", "WBGene00020989", "B3WFZ3", "WBGene00020989", "O01862", "WBGene00020989", "P34419", "WBGene00018370" ] }, "reaction_10567219": { "compartment": "compartment_5460", "id": "reaction_10567219", "reactome": "R-CEL-8874745", "name": "ACAA2 tetramer transfers acyl group from Ac-CoA to acyl-CoA forming 3OA-CoA and CoA-SH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113559", "species_1524038" ], "products": [ "species_29374", "species_8874749" ], "modifiers": [ [ "species_10567216", "catalyst" ] ], "additional_components": [ "O45552", "WBGene00009952" ] }, "reaction_10564674": { "compartment": "compartment_70101", "id": "reaction_10564674", "reactome": "R-CEL-8848250", "name": "ACBD6 binds LCFA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10564670", "species_164991" ], "products": [ "species_10564672" ], "modifiers": [], "additional_components": [ "WBGene00011731", "species_164991", "Q9XVJ0", "WBGene00011731" ] }, "reaction_10564645": { "compartment": "compartment_17957", "id": "reaction_10564645", "reactome": "R-CEL-8848246", "name": "DBI, ACBD7 bind MCFA-CoA and LCFA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8848288", "species_10564641" ], "products": [ "species_10564643" ], "modifiers": [], "additional_components": [ "species_164991", "species_5690542", "Q09603", "WBGene00001153", "Q09603", "WBGene00001153", "species_164991", "species_5690542" ] }, "reaction_10556532": { "compartment": "compartment_5460", "id": "reaction_10556532", "reactome": "R-CEL-5690066", "name": "ACOT2,9,THEM4,5 hydrolyse MCFA-CoA, LCFA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5690540", "species_113521" ], "products": [ "species_29374", "species_5690519" ], "modifiers": [ [ "species_10556529", "catalyst" ] ], "additional_components": [ "species_164991", "species_5690542", "species_174602", "species_5690531", "B3WFZ3", "WBGene00020989", "O01862", "WBGene00020989", "O45003", "WBGene00020989", "Q9GYN3", "WBGene00020989", "Q94245", "WBGene00019015" ] }, "reaction_10503674": { "compartment": "compartment_5460", "id": "reaction_10503674", "reactome": "R-CEL-71020", "name": "D-methylmalonyl-CoA <=> L-methylmalonyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71019" ], "products": [ "species_71009" ], "modifiers": [ [ "species_10503671", "catalyst" ] ], "additional_components": [ "WBGene00008415" ] }, "reaction_10503692": { "compartment": "compartment_5460", "id": "reaction_10503692", "reactome": "R-CEL-71031", "name": "propionyl-CoA + CO2 + ATP <=> D-methylmalonyl-CoA + ADP + orthophosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70843", "species_113593", "species_29376" ], "products": [ "species_113548", "species_113581", "species_71019" ], "modifiers": [ [ "species_10503689", "catalyst" ] ], "additional_components": [ "Q19842", "WBGene00017864", "Q20676", "WBGene00018701" ] }, "reaction_10508264": { "compartment": "compartment_5460", "id": "reaction_10508264", "reactome": "R-CEL-77338", "name": "Octanoyl-CoA+FAD<=>trans-Oct-2-enoyl-CoA+FADH2", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113596", "species_77337" ], "products": [ "species_77332", "species_31649" ], "modifiers": [ [ "species_10508261", "catalyst" ] ], "additional_components": [ "Q22347", "WBGene00020366" ] }, "reaction_10508250": { "compartment": "compartment_5460", "id": "reaction_10508250", "reactome": "R-CEL-77329", "name": "3-Oxooctanoyl-CoA+CoA-SH<=>Hexanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_77328" ], "products": [ "species_77326", "species_113559" ], "modifiers": [ [ "species_10508211", "catalyst" ] ], "additional_components": [ "P34255", "WBGene00015125", "Q9GYT0", "WBGene00020347" ] }, "reaction_10508252": { "compartment": "compartment_5460", "id": "reaction_10508252", "reactome": "R-CEL-77331", "name": "(S)-Hydroxyoctanoyl-CoA+NAD<=>3-Oxooctanoyl-CoA+NADH+H", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113526", "species_77330" ], "products": [ "species_113529", "species_29362", "species_77328" ], "modifiers": [ [ "species_10508194", "catalyst" ] ], "additional_components": [ "P41938", "WBGene00007129" ] }, "reaction_10508254": { "compartment": "compartment_5460", "id": "reaction_10508254", "reactome": "R-CEL-77333", "name": "trans-Oct-2-enoyl-CoA+H2O<=>(S)-Hydroxyoctanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77332", "species_113521" ], "products": [ "species_77330" ], "modifiers": [ [ "species_10503463", "catalyst" ] ], "additional_components": [ "P34559", "WBGene00001155" ] }, "reaction_10508272": { "compartment": "compartment_5460", "id": "reaction_10508272", "reactome": "R-CEL-77345", "name": "Decanoyl-CoA+FAD<=>trans-Dec-2-enoyl-CoA+FADH2", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77308", "species_113596" ], "products": [ "species_77343", "species_31649" ], "modifiers": [ [ "species_10508261", "catalyst" ] ], "additional_components": [ "Q22347", "WBGene00020366" ] }, "reaction_10569787": { "compartment": "compartment_5460", "id": "reaction_10569787", "reactome": "R-CEL-8952873", "name": "MECR dimer reduces tdec2-CoA to DEC-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77343", "species_113529", "species_113600" ], "products": [ "species_77308", "species_113563" ], "modifiers": [ [ "species_10569784", "catalyst" ] ], "additional_components": [ "O45903", "WBGene00012375" ] }, "reaction_10508266": { "compartment": "compartment_5460", "id": "reaction_10508266", "reactome": "R-CEL-77340", "name": "3-Oxodecanoyl-CoA+CoA-SH<=>Octanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_77339" ], "products": [ "species_77337", "species_113559" ], "modifiers": [ [ "species_10508211", "catalyst" ] ], "additional_components": [ "P34255", "WBGene00015125", "Q9GYT0", "WBGene00020347" ] }, "reaction_10508268": { "compartment": "compartment_5460", "id": "reaction_10508268", "reactome": "R-CEL-77342", "name": "(S)-Hydroxydecanoyl-CoA+NAD<=>3-Oxodecanoyl-CoA+NADH+H", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77341", "species_113526" ], "products": [ "species_77339", "species_113529", "species_29362" ], "modifiers": [ [ "species_10508194", "catalyst" ] ], "additional_components": [ "P41938", "WBGene00007129" ] }, "reaction_10508270": { "compartment": "compartment_5460", "id": "reaction_10508270", "reactome": "R-CEL-77344", "name": "trans-Dec-2-enoyl-CoA+H2O<=>(S)-Hydroxydecanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77343", "species_113521" ], "products": [ "species_77341" ], "modifiers": [ [ "species_10503463", "catalyst" ] ], "additional_components": [ "P34559", "WBGene00001155" ] }, "reaction_10508230": { "compartment": "compartment_5460", "id": "reaction_10508230", "reactome": "R-CEL-77299", "name": "palmitoyl-CoA+FAD<=>trans-Hexadec-2-enoyl-CoA+FADH2", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113596", "species_77281" ], "products": [ "species_77284", "species_31649" ], "modifiers": [ [ "species_10508227", "catalyst" ] ], "additional_components": [ "Q19057", "WBGene00017125" ] }, "reaction_10508232": { "compartment": "compartment_5460", "id": "reaction_10508232", "reactome": "R-CEL-77301", "name": "trans-Hexadec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxyhexadecanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77284", "species_113521" ], "products": [ "species_77300" ], "modifiers": [ [ "species_10508211", "catalyst" ] ], "additional_components": [ "P34255", "WBGene00015125", "Q9GYT0", "WBGene00020347" ] }, "reaction_10508234": { "compartment": "compartment_5460", "id": "reaction_10508234", "reactome": "R-CEL-77303", "name": "(S)-3-Hydroxyhexadecanoyl-CoA+NAD<=>3-Oxopalmitoyl-CoA+NADH+H", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113526", "species_77300" ], "products": [ "species_113529", "species_77302", "species_29362" ], "modifiers": [ [ "species_10508211", "catalyst" ] ], "additional_components": [ "P34255", "WBGene00015125", "Q9GYT0", "WBGene00020347" ] }, "reaction_10508236": { "compartment": "compartment_5460", "id": "reaction_10508236", "reactome": "R-CEL-77304", "name": "3-Oxopalmitoyl-CoA+CoA-SH<=>myristoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_77302" ], "products": [ "species_77272", "species_113559" ], "modifiers": [ [ "species_10508211", "catalyst" ] ], "additional_components": [ "P34255", "WBGene00015125", "Q9GYT0", "WBGene00020347" ] }, "reaction_10557528": { "compartment": "compartment_5460", "id": "reaction_10557528", "reactome": "R-CEL-5696004", "name": "ACSF2 ligates CoA-SH to MCFA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_113593", "species_5690531" ], "products": [ "species_159448", "species_159450", "species_5690542" ], "modifiers": [ [ "species_10557525", "catalyst" ] ], "additional_components": [ "WBGene00018488" ] }, "reaction_10508370": { "compartment": "compartment_5460", "id": "reaction_10508370", "reactome": "R-CEL-109341", "name": "dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113596", "species_109986" ], "products": [ "species_109990", "species_31649" ], "modifiers": [ [ "species_10508261", "catalyst" ] ], "additional_components": [ "Q22347", "WBGene00020366" ] }, "reaction_10508380": { "compartment": "compartment_5460", "id": "reaction_10508380", "reactome": "R-CEL-109343", "name": "Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113529", "species_109990", "species_29362" ], "products": [ "species_109994", "species_113526" ], "modifiers": [ [ "species_10508377", "catalyst" ] ], "additional_components": [ "Q23116", "WBGene00012177" ] }, "reaction_10542993": { "compartment": "compartment_12045", "id": "reaction_10542993", "reactome": "R-CEL-2161814", "name": "Arachidonic acid is hydroxylated to 19-HETE by CYP(2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_140356", "species_113601" ], "products": [ "species_113519", "species_113564", "species_2142836" ], "modifiers": [ [ "species_10542990", "catalyst" ] ], "additional_components": [ "A0A0M7RF98", "WBGene00018264", "Q27465", "WBGene00015135", "G5ECD0", "WBGene00007362", "Q27470", "WBGene00015709", "G5EE22", "WBGene00012448", "Q27471", "WBGene00016092", "H2KY69", "WBGene00015044", "Q27482", "WBGene00016768", "H2KYS3", "WBGene00000905", "Q27499", "WBGene00018334", "O02627", "WBGene00015399", "Q965T7", "WBGene00021710", "O02628", "WBGene00015400", "Q9N4Q4", "WBGene00021168", "O02641", "WBGene00019967", "Q9N5I1", "WBGene00019565", "O16220", "WBGene00016786", "O16362", "WBGene00018413", "O16482", "WBGene00016860", "O16670", "WBGene00018262", "O16671", "WBGene00018261", "O16673", "WBGene00018260", "O44649", "WBGene00019473", "O44650", "WBGene00019472", "O44651", "WBGene00019471", "O44652", "WBGene00019470", "O44655", "WBGene00015040", "O44656", "WBGene00015041", "O44657", "WBGene00015042", "O44658", "WBGene00015043", "O44704", "WBGene00016686", "O44706", "WBGene00016697", "O45364", "WBGene00008829", "O45659", "WBGene00010589", "O61204", "WBGene00015045", "O61935", "WBGene00020386", "O62377", "WBGene00011699", "O62378", "WBGene00011698", "P90771", "WBGene00007913", "Q20315", "WBGene00018333", "Q9N525", "WBGene00021412", "O17851", "WBGene00009226", "Q9N574", "WBGene00021200", "O45219", "WBGene00007140", "G5EC97", "WBGene00011830", "Q9XVA6", "WBGene00008499", "Q09660", "WBGene00000375", "G5EGT6", "WBGene00010354" ] }, "reaction_10543003": { "compartment": "compartment_12045", "id": "reaction_10543003", "reactome": "R-CEL-2161940", "name": "Arachidonic acid is hydroxylated to 20-HETE by CYP(3)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_140356", "species_113601" ], "products": [ "species_113519", "species_113564", "species_2142780" ], "modifiers": [ [ "species_10543000", "catalyst" ] ], "additional_components": [ "A0A0M7RF98", "WBGene00018264", "Q27465", "WBGene00015135", "G5ECD0", "WBGene00007362", "Q27470", "WBGene00015709", "G5EE22", "WBGene00012448", "Q27471", "WBGene00016092", "H2KY69", "WBGene00015044", "Q27482", "WBGene00016768", "H2KYS3", "WBGene00000905", "Q27499", "WBGene00018334", "O02627", "WBGene00015399", "Q965T7", "WBGene00021710", "O02628", "WBGene00015400", "Q9N4Q4", "WBGene00021168", "O02641", "WBGene00019967", "Q9N5I1", "WBGene00019565", "O16220", "WBGene00016786", "O16362", "WBGene00018413", "O16482", "WBGene00016860", "O16670", "WBGene00018262", "O16671", "WBGene00018261", "O16673", "WBGene00018260", "O44649", "WBGene00019473", "O44650", "WBGene00019472", "O44651", "WBGene00019471", "O44652", "WBGene00019470", "O44655", "WBGene00015040", "O44656", "WBGene00015041", "O44657", "WBGene00015042", "O44658", "WBGene00015043", "O44704", "WBGene00016686", "O44706", "WBGene00016697", "O45364", "WBGene00008829", "O45659", "WBGene00010589", "O61204", "WBGene00015045", "O61935", "WBGene00020386", "O62377", "WBGene00011699", "O62378", "WBGene00011698", "P90771", "WBGene00007913", "Q20315", "WBGene00018333", "Q9XVA6", "WBGene00008499", "G5EC97", "WBGene00011830", "G5EGT6", "WBGene00010354", "O17851", "WBGene00009226", "O45219", "WBGene00007140", "Q09660", "WBGene00000375", "Q9N525", "WBGene00021412", "Q9N574", "WBGene00021200" ] }, "reaction_10557108": { "compartment": "compartment_12045", "id": "reaction_10557108", "reactome": "R-CEL-5693742", "name": "FAAH hydrolyses AEA to AA and ETA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_5693754" ], "products": [ "species_1498751", "species_29768" ], "modifiers": [ [ "species_10557105", "catalyst" ] ], "additional_components": [ "Q17449", "WBGene00015047", "Q9U217", "WBGene00013232", "O45089", "WBGene00019068", "Q17447", "WBGene00015048", "Q9U243", "WBGene00013226", "Q9U2I8", "WBGene00012750" ] }, "reaction_10568057": { "compartment": "compartment_984", "id": "reaction_10568057", "reactome": "R-CEL-8932633", "name": "PON1,2,3:Ca2+ dimers hydrolyse 5-HETEL to 5-HETE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_8932801" ], "products": [ "species_8932804" ], "modifiers": [ [ "species_10568054", "catalyst" ] ], "additional_components": [ "species_74016", "B1V898", "WBGene00077701", "O01811", "WBGene00003170", "Q21427", "WBGene00010775", "Q2V071", "WBGene00044697", "Q966L1", "WBGene00017089" ] }, "reaction_10517856": { "compartment": "compartment_876", "id": "reaction_10517856", "reactome": "R-CEL-266070", "name": "LTC4 is exported from the cytosol by ABCC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_266066" ], "products": [ "species_266013" ], "modifiers": [ [ "species_10517853", "catalyst" ] ], "additional_components": [ "WBGene00003407" ] }, "reaction_10517848": { "compartment": "compartment_876", "id": "reaction_10517848", "reactome": "R-CEL-266046", "name": "GGT1, 5 dimers hydrolyse LTC4 to LTD4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_266013" ], "products": [ "species_266074", "species_210382" ], "modifiers": [ [ "species_10517845", "catalyst" ] ], "additional_components": [ "A0A486WVP7", "WBGene00020590", "B5BM47", "WBGene00020590", "H2L0B7", "WBGene00020590", "O18256", "WBGene00020590", "Q9N5V4", "WBGene00020590" ] }, "reaction_10542985": { "compartment": "compartment_12045", "id": "reaction_10542985", "reactome": "R-CEL-2161745", "name": "20oh-LTB4 is oxidised to 20cho-LTB4 by CYP4F2/4F3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29368", "species_29364", "species_2161636" ], "products": [ "species_29356", "species_29366", "species_2142740" ], "modifiers": [ [ "species_10516925", "catalyst" ] ], "additional_components": [ "Q9XVA6", "WBGene00008499", "G5EC97", "WBGene00011830", "G5EGT6", "WBGene00010354", "O17851", "WBGene00009226", "O45219", "WBGene00007140", "Q09660", "WBGene00000375", "Q9N525", "WBGene00021412", "Q9N574", "WBGene00021200" ] }, "reaction_10517866": { "compartment": "compartment_70101", "id": "reaction_10517866", "reactome": "R-CEL-266072", "name": "LTA4 is hydolysed to LTB4 by LTA4H", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_265281" ], "products": [ "species_266056" ], "modifiers": [ [ "species_10517863", "catalyst" ] ], "additional_components": [ "species_216785", "G5EFT4", "WBGene00016589" ] }, "reaction_10542988": { "compartment": "compartment_12045", "id": "reaction_10542988", "reactome": "R-CEL-2161792", "name": "20cho-LTB4 is oxidised to 20cooh-LTB4 by CYP4F2/4F3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29368", "species_29364", "species_2142740" ], "products": [ "species_2161582", "species_29356", "species_29366" ], "modifiers": [ [ "species_10516925", "catalyst" ] ], "additional_components": [ "Q9XVA6", "WBGene00008499", "G5EC97", "WBGene00011830", "G5EGT6", "WBGene00010354", "O17851", "WBGene00009226", "O45219", "WBGene00007140", "Q09660", "WBGene00000375", "Q9N525", "WBGene00021412", "Q9N574", "WBGene00021200" ] }, "reaction_10543012": { "compartment": "compartment_70101", "id": "reaction_10543012", "reactome": "R-CEL-2161959", "name": "12R-HpETE is reduced to 12R-HETE by GPX1/2/4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29450", "species_2142790" ], "products": [ "species_29356", "species_2142716", "species_111745" ], "modifiers": [ [ "species_10543009", "catalyst" ] ], "additional_components": [ "WBGene00019846" ] }, "reaction_10543014": { "compartment": "compartment_70101", "id": "reaction_10543014", "reactome": "R-CEL-2161999", "name": "12S-HpETE is reduced to 12S-HETE by GPX1/2/4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2142811", "species_29450" ], "products": [ "species_29356", "species_2142678", "species_111745" ], "modifiers": [ [ "species_10543009", "catalyst" ] ], "additional_components": [ "WBGene00019846" ] }, "reaction_10557116": { "compartment": "compartment_13977", "id": "reaction_10557116", "reactome": "R-CEL-5693751", "name": "FAAH2 hydrolyses AEA to AA and ETA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5693752", "species_5693747" ], "products": [ "species_5693736", "species_5693733" ], "modifiers": [ [ "species_10557113", "catalyst" ] ], "additional_components": [ "WBGene00013164" ] }, "reaction_10506598": { "compartment": "compartment_5460", "id": "reaction_10506598", "reactome": "R-CEL-74181", "name": "acetoacetyl-CoA + CoA <=> 2 acetyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_73871" ], "products": [ "species_113559" ], "modifiers": [ [ "species_10503443", "catalyst" ] ], "additional_components": [ "Q22100", "WBGene00002183" ] }, "reaction_10506586": { "compartment": "compartment_5460", "id": "reaction_10506586", "reactome": "R-CEL-74177", "name": "OXCT dimers transfer CoA from SUCC-CoA to ACA, forming ACA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70958", "species_73909" ], "products": [ "species_73871", "species_113536" ], "modifiers": [ [ "species_10506583", "catalyst" ] ], "additional_components": [ "Q09450", "WBGene00007330" ] }, "reaction_10506419": { "compartment": "compartment_5460", "id": "reaction_10506419", "reactome": "R-CEL-73918", "name": "acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73871", "species_113559" ], "products": [ "species_29374", "species_73917" ], "modifiers": [ [ "species_10506416", "catalyst" ] ], "additional_components": [ "WBGene00017769" ] }, "reaction_10506596": { "compartment": "compartment_5460", "id": "reaction_10506596", "reactome": "R-CEL-74180", "name": "HMG CoA => acetoacetic acid + acetyl CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73917" ], "products": [ "species_113559", "species_73909" ], "modifiers": [ [ "species_10506593", "catalyst" ] ], "additional_components": [ "Q95XN1", "WBGene00022150" ] }, "reaction_10557499": { "compartment": "compartment_70101", "id": "reaction_10557499", "reactome": "R-CEL-5694494", "name": "AACS ligates CoA-SH to ACA, forming ACA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_76194", "species_29666" ], "products": [ "species_111294", "species_191293", "species_76577" ], "modifiers": [ [ "species_10557496", "catalyst" ] ], "additional_components": [ "WBGene00006351" ] }, "reaction_10558315": { "compartment": "compartment_70101", "id": "reaction_10558315", "reactome": "R-CEL-6788597", "name": "HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191374" ], "products": [ "species_76183", "species_29666" ], "modifiers": [ [ "species_10558312", "catalyst" ] ], "additional_components": [ "species_114632", "Q95XN1", "WBGene00022150" ] }, "reaction_10536353": { "compartment": "compartment_161320", "id": "reaction_10536353", "reactome": "R-CEL-1605624", "name": "Beta-galactosidase hydrolyses GM1 to GM2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_1605677" ], "products": [ "species_1605637", "species_1605610" ], "modifiers": [ [ "species_10536350", "catalyst" ] ], "additional_components": [ "WBGene00011832" ] }, "reaction_10536324": { "compartment": "compartment_17938", "id": "reaction_10536324", "reactome": "R-CEL-1605591", "name": "Glucosylceramidase cleaves the glucosidic bond of glucocerebroside to form ceramide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_1605592" ], "products": [ "species_1605745", "species_1605673" ], "modifiers": [ [ "species_10536321", "catalyst" ] ], "additional_components": [ "G5ECR8", "WBGene00008706", "Q18276", "WBGene00004995" ] }, "reaction_10536360": { "compartment": "compartment_161320", "id": "reaction_10536360", "reactome": "R-CEL-1605632", "name": "Both hexosaminidase A and B can cleave GalNAc from globoside", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_1605608" ], "products": [ "species_1605716", "species_1605658" ], "modifiers": [ [ "species_10536357", "catalyst" ] ], "additional_components": [ "Q22492", "WBGene00020509" ] }, "reaction_10536680": { "compartment": "compartment_876", "id": "reaction_10536680", "reactome": "R-CEL-1640164", "name": "Ectonucleotide pyrophosphatase/phosphodiesterase 7 (ENPP7) hydrolyses sphingomyelin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_429776" ], "products": [ "species_429807", "species_1610735" ], "modifiers": [ [ "species_10536677", "catalyst" ] ], "additional_components": [ "Q22129", "WBGene00020195", "O45359", "WBGene00020195", "Q17540", "WBGene00020195" ] }, "reaction_10537833": { "compartment": "compartment_876", "id": "reaction_10537833", "reactome": "R-CEL-1861788", "name": "Glucosylceramidase 2 cleaves the glucosidic bond of glucocerebroside to form ceramide (plasma membrane)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1861782" ], "products": [ "species_429807", "species_70113" ], "modifiers": [ [ "species_10537830", "catalyst" ] ], "additional_components": [ "WBGene00019965" ] }, "reaction_10536363": { "compartment": "compartment_161320", "id": "reaction_10536363", "reactome": "R-CEL-1605717", "name": "Ganglioside GM2 activator presents GM2 to hexosaminidase for cleavage", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10536329", "species_1605610" ], "products": [ "species_10536331" ], "modifiers": [ [ "species_10536329", "catalyst" ] ], "additional_components": [ "WBGene00021095", "species_1605610", "O02106", "WBGene00021095", "WBGene00021095" ] }, "reaction_10536427": { "compartment": "compartment_876", "id": "reaction_10536427", "reactome": "R-CEL-1606273", "name": "Sphingomyelin phosphodiesterase 2 and 3 (SMPD2 and 3) hydrolyse sphingomyelin to ceramide (plasma membrane)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_429776" ], "products": [ "species_429807", "species_1610735" ], "modifiers": [ [ "species_10536424", "catalyst" ] ], "additional_components": [ "O45870", "WBGene00012105", "species_114632" ] }, "reaction_10536459": { "compartment": "compartment_161320", "id": "reaction_10536459", "reactome": "R-CEL-1606602", "name": "Acid ceramidase hydrolyses ceramide into sphingosine and free fatty acid (lysosome)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_1605673" ], "products": [ "species_1861779", "species_1606588" ], "modifiers": [ [ "species_10536456", "catalyst" ] ], "additional_components": [ "O45686", "WBGene00010769" ] }, "reaction_10536652": { "compartment": "compartment_20699", "id": "reaction_10536652", "reactome": "R-CEL-1638104", "name": "Ceramide glucosyltransferase (UGCG) catalyses the transfer of glucose to ceramide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_744227", "species_428270" ], "products": [ "species_1660674", "species_205687" ], "modifiers": [ [ "species_10536649", "catalyst" ] ], "additional_components": [ "WBGene00017625" ] }, "reaction_10567887": { "compartment": "compartment_17963", "id": "reaction_10567887", "reactome": "R-CEL-8878914", "name": "B3GALNT1 transfer GalNAc to Gb3Cer to form Gb4Cer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_735700", "species_8879102" ], "products": [ "species_8879101", "species_205687" ], "modifiers": [ [ "species_10567884", "catalyst" ] ], "additional_components": [ "WBGene00000270" ] }, "reaction_10558126": { "compartment": "compartment_70101", "id": "reaction_10558126", "reactome": "R-CEL-6785933", "name": "UGT8 transfers Gal from UDP-Gal to CERA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29452", "species_429807" ], "products": [ "species_6785915", "species_110096" ], "modifiers": [ [ "species_10558123", "catalyst" ] ], "additional_components": [ "WBGene00012013" ] }, "reaction_10537842": { "compartment": "compartment_70101", "id": "reaction_10537842", "reactome": "R-CEL-1861789", "name": "Glucosylceramidase 3 cleaves the glucosidic bond of glucocerebroside to form ceramide (cytosol)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1861764" ], "products": [ "species_194377", "species_70113" ], "modifiers": [ [ "species_10537839", "catalyst" ] ], "additional_components": [ "Q18758", "WBGene00016848", "Q9TZA0", "WBGene00017103" ] }, "reaction_10551475": { "compartment": "compartment_70101", "id": "reaction_10551475", "reactome": "R-CEL-5339535", "name": "GLTPD1 transports C1P from plasma membrane to Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1638840" ], "products": [ "species_5339515" ], "modifiers": [ [ "species_10551472", "catalyst" ] ], "additional_components": [ "WBGene00018632" ] }, "reaction_10536660": { "compartment": "compartment_876", "id": "reaction_10536660", "reactome": "R-CEL-1638845", "name": "CERK phosphorylates CERA to form C1P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_429807", "species_113592" ], "products": [ "species_29370", "species_1638840" ], "modifiers": [ [ "species_10536657", "catalyst" ] ], "additional_components": [ "WBGene00020398" ] }, "reaction_10536373": { "compartment": "compartment_161320", "id": "reaction_10536373", "reactome": "R-CEL-1605736", "name": "Alpha-galactosidase A removes a terminal galactose from alpha-D-galactoside oligomers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605716", "species_1605715" ], "products": [ "species_1605637", "species_1605601" ], "modifiers": [ [ "species_10536370", "catalyst" ] ], "additional_components": [ "Q21801", "WBGene00011095" ] }, "reaction_10536437": { "compartment": "compartment_17957", "id": "reaction_10536437", "reactome": "R-CEL-1606288", "name": "Sphingomyelin phosphodiesterase 4 (SMPD4) hydrolyses sphingomyelin to ceramide (ER membrane)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113519", "species_1606283" ], "products": [ "species_428256", "species_1606280" ], "modifiers": [ [ "species_10536434", "catalyst" ] ], "additional_components": [ "Q95ZR2", "WBGene00011037", "species_114632" ] }, "reaction_10536439": { "compartment": "compartment_161320", "id": "reaction_10536439", "reactome": "R-CEL-1606312", "name": "Beta-galactosidase can also hydrolyse globosides to form cerebrosides", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_1605601" ], "products": [ "species_1605637", "species_1605592" ], "modifiers": [ [ "species_10536350", "catalyst" ] ], "additional_components": [ "WBGene00011832" ] }, "reaction_10536345": { "compartment": "compartment_161320", "id": "reaction_10536345", "reactome": "R-CEL-1605595", "name": "Hexosaminidase A cleaves GalNAc from GM2 to form GM3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_10536331" ], "products": [ "species_10536329", "species_1605658", "species_1605641" ], "modifiers": [ [ "species_10536342", "catalyst" ] ], "additional_components": [ "species_1605610", "O02106", "WBGene00021095", "WBGene00021095", "Q22492", "WBGene00020509" ] }, "reaction_10536381": { "compartment": "compartment_161320", "id": "reaction_10536381", "reactome": "R-CEL-1605797", "name": "Sphingomyelin phosphodiesterase (SMPD1) hydrolyses sphingomyelin to ceramide (lysosome)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_1605713" ], "products": [ "species_1605750", "species_1605673" ], "modifiers": [ [ "species_10536378", "catalyst" ] ], "additional_components": [ "WBGene00000212" ] }, "reaction_10551516": { "compartment": "compartment_876", "id": "reaction_10551516", "reactome": "R-CEL-5340320", "name": "GLTP transports GSL from plasma membrane to ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5340315" ], "products": [ "species_5340299" ], "modifiers": [ [ "species_10551513", "catalyst" ] ], "additional_components": [ "WBGene00022347" ] }, "reaction_10565820": { "compartment": "compartment_12045", "id": "reaction_10565820", "reactome": "R-CEL-8857662", "name": "ESYT1:ESYT2:ESYT3 transport GPL from plasma membrane to ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8857646" ], "products": [ "species_8857684" ], "modifiers": [ [ "species_10565817", "catalyst" ], [ "species_74016", "catalyst" ] ], "additional_components": [ "A0A679L8R0", "WBGene00020443" ] }, "reaction_10536447": { "compartment": "compartment_161320", "id": "reaction_10536447", "reactome": "R-CEL-1606564", "name": "Galactocerebrosidase cleaves the galactosyl bond of galactocerebroside to form ceramide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_1606573" ], "products": [ "species_1605745", "species_1605673" ], "modifiers": [ [ "species_10536444", "catalyst" ] ], "additional_components": [ "WBGene00016207" ] }, "reaction_10523456": { "compartment": "compartment_70101", "id": "reaction_10523456", "reactome": "R-CEL-429698", "name": "PRKD1,2,3 phosphorylates COL4A3BP-2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10523428" ], "products": [ "species_29370", "species_10523431" ], "modifiers": [ [ "species_10523453", "catalyst" ] ], "additional_components": [ "WBGene00009120", "WBGene00009120", "Q9XUJ7", "WBGene00012352", "O45818", "WBGene00012019" ] }, "reaction_10556864": { "compartment": "compartment_12045", "id": "reaction_10556864", "reactome": "R-CEL-5692261", "name": "ALDH3A2-1 oxidises HD2NAL to PALM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_428671", "species_29360" ], "products": [ "species_70106", "species_3632881", "species_73473" ], "modifiers": [ [ "species_10556861", "catalyst" ] ], "additional_components": [ "A0A486WWU7", "WBGene00000110", "O44555", "WBGene00000111" ] }, "reaction_10523106": { "compartment": "compartment_70101", "id": "reaction_10523106", "reactome": "R-CEL-428214", "name": "sphinganine (dihydrosphingosine) +ATP => sphinganine 1-phosphate + ADP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_428163" ], "products": [ "species_29370", "species_428275" ], "modifiers": [ [ "species_10520872", "catalyst" ] ], "additional_components": [ "WBGene00007918" ] }, "reaction_10570149": { "compartment": "compartment_12045", "id": "reaction_10570149", "reactome": "R-CEL-8959462", "name": "SAMD8 transforms PE and CERA to CPE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8959490", "species_8959486" ], "products": [ "species_8959463" ], "modifiers": [ [ "species_10570146", "catalyst" ] ], "additional_components": [ "WBGene00018735" ] }, "reaction_10557124": { "compartment": "compartment_12045", "id": "reaction_10557124", "reactome": "R-CEL-5693761", "name": "FA2H hydroxylates CERA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_428256" ], "products": [ "species_5693768", "species_29356" ], "modifiers": [ [ "species_10557121", "catalyst" ] ], "additional_components": [ "WBGene00007707" ] }, "reaction_10523111": { "compartment": "compartment_70101", "id": "reaction_10523111", "reactome": "R-CEL-428231", "name": "ceramide + H2O <=> stearate + sphingosine [endoplasmic reticulum]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_428256" ], "products": [ "species_428193", "species_428198" ], "modifiers": [ [ "species_10523108", "catalyst" ] ], "additional_components": [ "WBGene00020947" ] }, "reaction_10523207": { "compartment": "compartment_70101", "id": "reaction_10523207", "reactome": "R-CEL-428676", "name": "sphingosine 1-phosphate => phosphoethanolamine + hexadec-2-enal", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428203" ], "products": [ "species_428671", "species_428686" ], "modifiers": [ [ "species_10523204", "catalyst" ] ], "additional_components": [ "WBGene00004981" ] }, "reaction_10563430": { "compartment": "compartment_13977", "id": "reaction_10563430", "reactome": "R-CEL-6808464", "name": "ALDH3B2 oxidises HXAL to PALM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_6808468", "species_29360" ], "products": [ "species_2453691", "species_70106", "species_73473" ], "modifiers": [ [ "species_10563427", "catalyst" ] ], "additional_components": [ "O44555", "WBGene00000111", "A0A486WWU7", "WBGene00000110" ] }, "reaction_10523209": { "compartment": "compartment_70101", "id": "reaction_10523209", "reactome": "R-CEL-428681", "name": "sphinganine 1-phosphate => phosphoethanolamine + hexadecanal", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428275" ], "products": [ "species_428686", "species_428663" ], "modifiers": [ [ "species_10523204", "catalyst" ] ], "additional_components": [ "WBGene00004981" ] }, "reaction_10523051": { "compartment": "compartment_70101", "id": "reaction_10523051", "reactome": "R-CEL-428123", "name": "3-ketosphinganine + NADPH + H+ => sphinganine + NADP+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_428182" ], "products": [ "species_29366", "species_428163" ], "modifiers": [ [ "species_10523048", "catalyst" ] ], "additional_components": [ "WBGene00021367" ] }, "reaction_10523468": { "compartment": "compartment_70101", "id": "reaction_10523468", "reactome": "R-CEL-429714", "name": "monophospho-CERT + 2 ATP => multiphospho-CERT + 2 ADP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10523431" ], "products": [ "species_29370", "species_10523460" ], "modifiers": [ [ "species_10523465", "catalyst" ] ], "additional_components": [ "WBGene00009120", "WBGene00009120", "WBGene00013709" ] }, "reaction_10523217": { "compartment": "compartment_984", "id": "reaction_10523217", "reactome": "R-CEL-428690", "name": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [extracellular]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_419305", "species_109276" ], "products": [ "species_109277", "species_428662" ], "modifiers": [ [ "species_10523214", "catalyst" ] ], "additional_components": [ "WBGene00018756" ] }, "reaction_10523251": { "compartment": "compartment_70101", "id": "reaction_10523251", "reactome": "R-CEL-428696", "name": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - PPAP]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428203", "species_29356" ], "products": [ "species_428682", "species_29372" ], "modifiers": [ [ "species_10523248", "catalyst" ] ], "additional_components": [ "Q22250", "WBGene00011524", "H2KZD1", "WBGene00018756", "Q10022", "WBGene00020895", "Q19403", "WBGene00008749" ] }, "reaction_10573237": { "compartment": "compartment_70101", "id": "reaction_10573237", "reactome": "R-CEL-9695890", "name": "SPNS2 transports S1P from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428203" ], "products": [ "species_419305" ], "modifiers": [ [ "species_10573234", "catalyst" ] ], "additional_components": [ "A0A3B1DV80", "WBGene00013739", "Q19235", "WBGene00008598", "O01927", "WBGene00007549", "Q18545", "WBGene00008033" ] }, "reaction_10523509": { "compartment": "compartment_876", "id": "reaction_10523509", "reactome": "R-CEL-429786", "name": "phosphatidylcholine + ceramide <=> sphingomyelin + diacylglycerol [SGMS2]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_429802", "species_429807" ], "products": [ "species_429776", "species_112275" ], "modifiers": [ [ "species_10523506", "catalyst" ] ], "additional_components": [ "Q9U3D4", "WBGene00004892", "Q965Q4", "WBGene00004894", "Q9TYV2", "WBGene00021075", "Q20735", "WBGene00004893" ] }, "reaction_10523093": { "compartment": "compartment_70101", "id": "reaction_10523093", "reactome": "R-CEL-428185", "name": "sphinganine + stearyl-CoA => dihydroceramide + CoASH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428139", "species_428163" ], "products": [ "species_428126", "species_76194" ], "modifiers": [ [ "species_10523090", "catalyst" ] ], "additional_components": [ "Q9XWE9", "WBGene00006505", "G5ED45", "WBGene00002043", "Q7Z139", "WBGene00002044" ] }, "reaction_10523126": { "compartment": "compartment_70101", "id": "reaction_10523126", "reactome": "R-CEL-428259", "name": "dihydroceramide + NAD(P)H + H+ + O2 => ceramide + NAD(P)+ + H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_428206", "species_428126", "species_29368" ], "products": [ "species_428218", "species_29356", "species_428256" ], "modifiers": [ [ "species_10523123", "catalyst" ] ], "additional_components": [ "species_73473", "species_29364", "species_29360", "species_29366", "O44186", "WBGene00017996", "G5EC63", "WBGene00013197" ] }, "reaction_10557561": { "compartment": "compartment_876", "id": "reaction_10557561", "reactome": "R-CEL-5696080", "name": "ALDH3B1 oxidises HXAL to PALM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_428663", "species_29360" ], "products": [ "species_70106", "species_3632881", "species_73473" ], "modifiers": [ [ "species_10557558", "catalyst" ] ], "additional_components": [ "A0A486WWU7", "WBGene00000110", "O44555", "WBGene00000111" ] }, "reaction_10523129": { "compartment": "compartment_70101", "id": "reaction_10523129", "reactome": "R-CEL-428260", "name": "dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_428126", "species_29368", "species_29364" ], "products": [ "species_29356", "species_29366", "species_9025544" ], "modifiers": [ [ "species_10523123", "catalyst" ] ], "additional_components": [ "O44186", "WBGene00017996", "G5EC63", "WBGene00013197" ] }, "reaction_10523514": { "compartment": "compartment_20699", "id": "reaction_10523514", "reactome": "R-CEL-429798", "name": "phosphatidylcholine + ceramide <=> sphingomyelin + diacylglycerol [SGMS1]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_429785", "species_428270" ], "products": [ "species_429773", "species_429789" ], "modifiers": [ [ "species_10523511", "catalyst" ] ], "additional_components": [ "WBGene00004892" ] }, "reaction_10573242": { "compartment": "compartment_70101", "id": "reaction_10573242", "reactome": "R-CEL-9695949", "name": "SPHK2 phosphorylates SPG to S1P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_428193" ], "products": [ "species_428203", "species_29370" ], "modifiers": [ [ "species_10523103", "catalyst" ], [ "species_10573240", "inhibitor" ] ], "additional_components": [ "WBGene00007918", "Q18425", "WBGene00007918" ] }, "reaction_10523132": { "compartment": "compartment_70101", "id": "reaction_10523132", "reactome": "R-CEL-428273", "name": "SPHK1 phosphorylates SPG to S1P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_428193" ], "products": [ "species_428203", "species_29370" ], "modifiers": [ [ "species_10520872", "catalyst" ] ], "additional_components": [ "WBGene00007918" ] }, "reaction_10523101": { "compartment": "compartment_20699", "id": "reaction_10523101", "reactome": "R-CEL-428205", "name": "ceramide + H2O => stearate + sphingosine [Golgi]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_428270" ], "products": [ "species_428248", "species_8934421" ], "modifiers": [ [ "species_10523098", "catalyst" ] ], "additional_components": [ "WBGene00020947" ] }, "reaction_10536978": { "compartment": "compartment_20699", "id": "reaction_10536978", "reactome": "R-CEL-1655851", "name": "S2P hydrolyzes SREBP1A,1C,2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10536972" ], "products": [ "species_10536935" ], "modifiers": [ [ "species_10522008", "catalyst" ] ], "additional_components": [ "WBGene00004735", "WBGene00004735", "WBGene00013225" ] }, "reaction_10542407": { "compartment": "compartment_7660", "id": "reaction_10542407", "reactome": "R-CEL-2065539", "name": "SREBP1A,1C,2:Importin beta-1 dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10536955", "species_10542403" ], "products": [ "species_10536951", "species_10542405" ], "modifiers": [], "additional_components": [ "Q9XX00", "WBGene00004735", "Q9BIB8", "WBGene00002075", "O17915", "WBGene00004302", "species_29438", "Q9XX00", "WBGene00004735", "O17915", "WBGene00004302", "species_29438", "Q9BIB8", "WBGene00002075" ] }, "reaction_10542409": { "compartment": "compartment_70101", "id": "reaction_10542409", "reactome": "R-CEL-2065549", "name": "SREBP1A,1C,2 binds SREBP1A,1C,2 forming dimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10536935" ], "products": [ "species_10536941" ], "modifiers": [], "additional_components": [ "WBGene00004735", "Q9XX00", "WBGene00004735" ] }, "reaction_10542411": { "compartment": "compartment_70101", "id": "reaction_10542411", "reactome": "R-CEL-2065550", "name": "SREBP1A,1C,2 binds Importin beta-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10536941", "species_10516892" ], "products": [ "species_10536943" ], "modifiers": [], "additional_components": [ "Q9XX00", "WBGene00004735", "WBGene00002075", "Q9BIB8", "WBGene00002075", "Q9XX00", "WBGene00004735" ] }, "reaction_10536957": { "compartment": "compartment_70101", "id": "reaction_10536957", "reactome": "R-CEL-1655831", "name": "SREBP1A,1C,2 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10536943" ], "products": [ "species_10536955" ], "modifiers": [], "additional_components": [ "Q9BIB8", "WBGene00002075", "Q9XX00", "WBGene00004735", "Q9XX00", "WBGene00004735", "Q9BIB8", "WBGene00002075" ] }, "reaction_10557203": { "compartment": "compartment_12045", "id": "reaction_10557203", "reactome": "R-CEL-5694077", "name": "EPHX1 hydrates BaP4,5O to BaP4,5-DHD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_5694080" ], "products": [ "species_5694091" ], "modifiers": [ [ "species_10557200", "catalyst" ] ], "additional_components": [ "WBGene00020909" ] }, "reaction_10568323": { "compartment": "compartment_70101", "id": "reaction_10568323", "reactome": "R-CEL-8937442", "name": "CES3 hydrolyses CHEST to CHOL and LCFA(-)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_163579" ], "products": [ "species_8876730", "species_216762" ], "modifiers": [ [ "species_10568320", "catalyst" ] ], "additional_components": [ "O01302", "WBGene00011362", "P92016", "WBGene00011364", "Q04457", "WBGene00001578", "Q21266", "WBGene00019477", "A0A1C3NSL8", "WBGene00017478", "Q22008", "WBGene00020125", "G5EDJ7", "WBGene00013875", "Q23268", "WBGene00013873", "H2L0K7", "WBGene00020330", "Q4LDP0", "WBGene00020891", "H9G2Y9", "WBGene00013874", "Q9XW75", "WBGene00013540" ] }, "reaction_10517444": { "compartment": "compartment_17960", "id": "reaction_10517444", "reactome": "R-CEL-217255", "name": "FMO1:FAD N-oxidises TAM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_113601", "species_159154" ], "products": [ "species_113519", "species_113564", "species_217269" ], "modifiers": [ [ "species_10517441", "catalyst" ] ], "additional_components": [ "species_113596", "G5EBJ9", "WBGene00001477", "G5ECJ8", "WBGene00001478", "G5ED43", "WBGene00001480", "G5EDG8", "WBGene00001479", "G5EDP6", "WBGene00001476" ] }, "reaction_10517461": { "compartment": "compartment_17960", "id": "reaction_10517461", "reactome": "R-CEL-217258", "name": "FMO2:FAD:Mg2+ S-oxidises MTZ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_113601", "species_217315" ], "products": [ "species_113519", "species_113564", "species_217320" ], "modifiers": [ [ "species_10517458", "catalyst" ] ], "additional_components": [ "G5EBJ9", "WBGene00001477", "G5ECJ8", "WBGene00001478", "G5ED43", "WBGene00001480", "G5EDG8", "WBGene00001479", "G5EDP6", "WBGene00001476", "species_114632", "species_113596" ] }, "reaction_10509718": { "compartment": "compartment_17957", "id": "reaction_10509718", "reactome": "R-CEL-139970", "name": "FMO3:FAD N-oxidises TMA to TMAO", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_30373", "species_113601" ], "products": [ "species_113519", "species_113564", "species_140963" ], "modifiers": [ [ "species_10509715", "catalyst" ] ], "additional_components": [ "G5ECJ8", "WBGene00001478", "G5ED43", "WBGene00001480", "G5EDG8", "WBGene00001479", "G5EBJ9", "WBGene00001477", "G5EDP6", "WBGene00001476", "species_113596" ] }, "reaction_10504257": { "compartment": "compartment_70101", "id": "reaction_10504257", "reactome": "R-CEL-71707", "name": "ethanol + NAD+ => acetaldehyde + NADH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30203", "species_29360" ], "products": [ "species_70106", "species_29510", "species_73473" ], "modifiers": [ [ "species_10504254", "catalyst" ] ], "additional_components": [ "species_216785", "Q17335", "WBGene00019240" ] }, "reaction_10557573": { "compartment": "compartment_5460", "id": "reaction_10557573", "reactome": "R-CEL-5696091", "name": "ALDH1B1 tetramer oxidises CH3CHO to CH3COOH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113532", "species_113526", "species_113521" ], "products": [ "species_113529", "species_29362", "species_113539" ], "modifiers": [ [ "species_10557570", "catalyst" ] ], "additional_components": [ "Q20780", "WBGene00000107", "Q9TXM0", "WBGene00000108" ] }, "reaction_10556853": { "compartment": "compartment_70101", "id": "reaction_10556853", "reactome": "R-CEL-5692237", "name": "ADH5 oxidises S-HMGSH to S-FGSH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5692221", "species_29360" ], "products": [ "species_5692249", "species_70106", "species_73473" ], "modifiers": [ [ "species_10556850", "catalyst" ] ], "additional_components": [ "species_216785", "Q17335", "WBGene00019240" ] }, "reaction_10504267": { "compartment": "compartment_5460", "id": "reaction_10504267", "reactome": "R-CEL-71723", "name": "acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113532", "species_113526", "species_113521" ], "products": [ "species_113529", "species_29362", "species_113539" ], "modifiers": [ [ "species_10504264", "catalyst" ] ], "additional_components": [ "Q20780", "WBGene00000107" ] }, "reaction_10504285": { "compartment": "compartment_70101", "id": "reaction_10504285", "reactome": "R-CEL-71735", "name": "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_29416", "species_76194" ], "products": [ "species_111294", "species_76183", "species_76577" ], "modifiers": [ [ "species_10504282", "catalyst" ] ], "additional_components": [ "WBGene00007969" ] }, "reaction_10557063": { "compartment": "compartment_17957", "id": "reaction_10557063", "reactome": "R-CEL-5693691", "name": "CES1 trimer.CES2 hydrolyse COCN to BEG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113519", "species_5693702" ], "products": [ "species_156540", "species_5693711", "species_5693712" ], "modifiers": [ [ "species_10557060", "catalyst" ] ], "additional_components": [ "H9G2Y9", "WBGene00013874", "Q9XW75", "WBGene00013540", "O01302", "WBGene00011362", "P92016", "WBGene00011364", "Q04457", "WBGene00001578", "Q21266", "WBGene00019477", "A0A1C3NSL8", "WBGene00017478", "Q22008", "WBGene00020125", "G5EDJ7", "WBGene00013875", "Q23268", "WBGene00013873", "H2L0K7", "WBGene00020330", "Q4LDP0", "WBGene00020891" ] }, "reaction_10556121": { "compartment": "compartment_12045", "id": "reaction_10556121", "reactome": "R-CEL-5689000", "name": "AADAC deacetylates PHEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_5689006" ], "products": [ "species_5689001", "species_5688995" ], "modifiers": [ [ "species_10556118", "catalyst" ] ], "additional_components": [ "Q19839", "WBGene00009186", "Q9XWL5", "WBGene00012810", "Q7JMM5", "WBGene00017515", "Q94187", "WBGene00017515" ] }, "reaction_10558105": { "compartment": "compartment_70101", "id": "reaction_10558105", "reactome": "R-CEL-6784959", "name": "BPHL hydrolyses VACV to ACV", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_6784964" ], "products": [ "species_29702", "species_561052" ], "modifiers": [ [ "species_10558102", "catalyst" ] ], "additional_components": [ "WBGene00019280" ] }, "reaction_10556888": { "compartment": "compartment_70101", "id": "reaction_10556888", "reactome": "R-CEL-5692283", "name": "ALD3A1 oxidises 4HPCP to CXPA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5692409", "species_29356", "species_29366" ], "products": [ "species_70106", "species_5692433", "species_29364" ], "modifiers": [ [ "species_10556870", "catalyst" ], [ "species_10556882", "catalyst" ], [ "species_10556886", "inhibitor" ] ], "additional_components": [ "A0A486WWU7", "WBGene00000110", "O44555", "WBGene00000111", "O02219", "WBGene00000095", "species_8936852", "O44712", "WBGene00000096", "O44712", "WBGene00000096", "O02219", "WBGene00000095" ] }, "reaction_10568168": { "compartment": "compartment_70101", "id": "reaction_10568168", "reactome": "R-CEL-8936442", "name": "MARC1,MARC2 reduce N-hydroxylated compounds", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_8936443", "species_73473" ], "products": [ "species_29356", "species_29468", "species_29360" ], "modifiers": [ [ "species_10568165", "catalyst" ] ], "additional_components": [ "CHEBI:21437", "U4PC34", "WBGene00018925", "Q93315", "WBGene00007848", "O16521", "WBGene00020268", "P91321", "WBGene00018925", "O45394", "WBGene00018925" ] }, "reaction_10544101": { "compartment": "compartment_5460", "id": "reaction_10544101", "reactome": "R-CEL-2395512", "name": "FDXR transfers electrons to FDX1,2 (FDX1L)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10533041", "species_10544097" ], "products": [ "species_10533037", "species_113529", "species_10544099" ], "modifiers": [], "additional_components": [ "CHEBI:33737", "Q9NA32", "WBGene00013532", "species_31649", "Q9U1X0", "WBGene00013376", "CHEBI:33738", "Q9NA32", "WBGene00013532", "species_113596", "Q9U1X0", "WBGene00013376" ] }, "reaction_10544103": { "compartment": "compartment_5460", "id": "reaction_10544103", "reactome": "R-CEL-2395517", "name": "NADPH transfers electrons to FDXR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113529", "species_10544099", "species_113600" ], "products": [ "species_113563", "species_10544097" ], "modifiers": [], "additional_components": [ "species_113596", "Q9U1X0", "WBGene00013376", "species_31649", "Q9U1X0", "WBGene00013376" ] }, "reaction_10533044": { "compartment": "compartment_5460", "id": "reaction_10533044", "reactome": "R-CEL-1362408", "name": "FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10533037", "species_379721", "species_10533030" ], "products": [ "species_10533039", "species_379697", "species_10533041" ], "modifiers": [ [ "species_10533030", "catalyst" ], [ "species_10533037", "catalyst" ] ], "additional_components": [ "CHEBI:33738", "Q9NA32", "WBGene00013532", "Q9TY03", "WBGene00001486", "species_113531", "O61741", "WBGene00015021", "O45948", "WBGene00012885", "A0A2R8F5A8", "WBGene00302998", "Q9TY03", "WBGene00001486", "O61741", "WBGene00015021", "O45948", "WBGene00012885", "A0A2R8F5A8", "WBGene00302998", "CHEBI:33739", "CHEBI:33737", "Q9NA32", "WBGene00013532", "Q9TY03", "WBGene00001486", "species_113531", "O61741", "WBGene00015021", "O45948", "WBGene00012885", "A0A2R8F5A8", "WBGene00302998", "CHEBI:33738", "Q9NA32", "WBGene00013532" ] }, "reaction_10567878": { "compartment": "compartment_5460", "id": "reaction_10567878", "reactome": "R-CEL-8878815", "name": "Formation of 4Fe-4S cluster on ISCA1:ISCA2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10567869", "species_10567857" ], "products": [ "species_10567855", "species_10567871" ], "modifiers": [ [ "species_10567876", "catalyst" ] ], "additional_components": [ "A5HWB2", "WBGene00012666", "Q9XVZ9", "WBGene00013218", "CHEBI:33739", "Q9XTU9", "WBGene00013029", "WBGene00013029", "CHEBI:49883", "A5HWB2", "WBGene00012666", "Q9XVZ9", "WBGene00013218", "WBGene00001033" ] }, "reaction_10533049": { "compartment": "compartment_5460", "id": "reaction_10533049", "reactome": "R-CEL-1362416", "name": "Frataxin binds iron", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113531", "species_10533047" ], "products": [ "species_10533030" ], "modifiers": [], "additional_components": [ "Q9TY03", "WBGene00001486", "O61741", "WBGene00015021", "O45948", "WBGene00012885", "A0A2R8F5A8", "WBGene00302998", "Q9TY03", "WBGene00001486", "species_113531", "O61741", "WBGene00015021", "O45948", "WBGene00012885", "A0A2R8F5A8", "WBGene00302998" ] }, "reaction_10554321": { "compartment": "compartment_17963", "id": "reaction_10554321", "reactome": "R-CEL-5653873", "name": "SLC2A1 tetramer transports Glc from cytosol to Golgi lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70113" ], "products": [ "species_964746" ], "modifiers": [ [ "species_10554318", "catalyst" ] ], "additional_components": [ "Q21381", "WBGene00043980", "Q21382", "WBGene00043980", "Q21385", "WBGene00043980", "Q5WRR9", "WBGene00043980", "Q9GYQ1", "WBGene00043980", "Q9NEI8", "WBGene00043980" ] }, "reaction_10562084": { "compartment": "compartment_70101", "id": "reaction_10562084", "reactome": "R-CEL-6799495", "name": "GLYCTK phosphorylates DGA to 3PDGA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6799497", "species_113592" ], "products": [ "species_70106", "species_29370", "species_6799493" ], "modifiers": [ [ "species_10562081", "catalyst" ] ], "additional_components": [ "WBGene00015733" ] }, "reaction_10502888": { "compartment": "compartment_70101", "id": "reaction_10502888", "reactome": "R-CEL-70349", "name": "DAK dimer phosphorylates D-glyceraldehyde to form D-glyceraldehyde 3-phosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30393", "species_113592" ], "products": [ "species_29578", "species_29370" ], "modifiers": [ [ "species_10502885", "catalyst" ] ], "additional_components": [ "Q9N5C4", "WBGene00020962", "species_114632" ] }, "reaction_10502878": { "compartment": "compartment_70101", "id": "reaction_10502878", "reactome": "R-CEL-70342", "name": "ALDOB tetramer cleaves Fru-1-P to GA and DHAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_31221" ], "products": [ "species_30393", "species_75970" ], "modifiers": [ [ "species_10502875", "catalyst" ] ], "additional_components": [ "P54216", "WBGene00011474" ] }, "reaction_10554242": { "compartment": "compartment_70101", "id": "reaction_10554242", "reactome": "R-CEL-5652172", "name": "AKR1B1 reduces Glc to D-sorbitol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_70113" ], "products": [ "species_29366", "species_5652213" ], "modifiers": [ [ "species_10513654", "catalyst" ] ], "additional_components": [ "WBGene00016985" ] }, "reaction_10554254": { "compartment": "compartment_70101", "id": "reaction_10554254", "reactome": "R-CEL-5652195", "name": "SORD oxidizes D-sorbitol to Fru", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5652213", "species_29360" ], "products": [ "species_29532", "species_70106", "species_73473" ], "modifiers": [ [ "species_10554251", "catalyst" ] ], "additional_components": [ "species_216785", "Q21702", "WBGene00011003" ] }, "reaction_10502896": { "compartment": "compartment_70101", "id": "reaction_10502896", "reactome": "R-CEL-70361", "name": "GALT transfers UMP from UDP-Glc to Gal1P to form UDP-Gal", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30170", "species_29410" ], "products": [ "species_29452", "species_29548" ], "modifiers": [ [ "species_10502893", "catalyst" ] ], "additional_components": [ "WBGene00014203" ] }, "reaction_10502906": { "compartment": "compartment_70101", "id": "reaction_10502906", "reactome": "R-CEL-70369", "name": "GALE:NAD+ dimer reversibly epimerises UDP-Gal to UDP-Glc", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29452" ], "products": [ "species_29410" ], "modifiers": [ [ "species_10502903", "catalyst" ] ], "additional_components": [ "species_29360", "Q564Q1", "WBGene00008132" ] }, "reaction_10504192": { "compartment": "compartment_70101", "id": "reaction_10504192", "reactome": "R-CEL-71593", "name": "((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)glycogenin => poly{(1,4)-alpha-glucosyl} glycogenin + alpha-D-glucose", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10504148" ], "products": [ "species_10504189", "species_70113" ], "modifiers": [ [ "species_10504153", "catalyst" ] ], "additional_components": [ "G5ECZ5", "WBGene00011684", "H2KYQ5", "WBGene00006863", "O45819", "WBGene00012020", "species_266099", "G5ECZ5", "WBGene00011684", "H2KYQ5", "WBGene00006863", "O45819", "WBGene00012020", "species_266099", "WBGene00011050" ] }, "reaction_10526209": { "compartment": "compartment_70101", "id": "reaction_10526209", "reactome": "R-CEL-453342", "name": "PGYM dimer, b form + 2 AMP <=> PGYM b dimer:AMP complex", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10504012", "species_76577" ], "products": [ "species_10526195" ], "modifiers": [ [ "species_113592", "inhibitor" ], [ "species_30537", "inhibitor" ] ], "additional_components": [ "Q9N5U1", "WBGene00020696", "species_76577", "Q9N5U1", "WBGene00020696" ] }, "reaction_10504099": { "compartment": "compartment_70101", "id": "reaction_10504099", "reactome": "R-CEL-71541", "name": "glycogen phosphorylase (PYGM) dimer b + 2 ATP => glycogen phosphorylase (PYGM) dimer a + 2 ADP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10504012", "species_113592" ], "products": [ "species_29370", "species_10504017" ], "modifiers": [ [ "species_10504096", "catalyst" ], [ "species_74016", "catalyst" ] ], "additional_components": [ "Q9N5U1", "WBGene00020696", "Q9N5U1", "WBGene00020696", "Q9N3L4", "WBGene00021753", "P34335", "WBGene00015754", "H2L0I6", "WBGene00022059", "Q11083", "WBGene00020378", "P04630", "WBGene00000285", "G5EF37", "WBGene00003934", "A0A2C9C3L3", "WBGene00020378", "Q18136", "WBGene00006861", "Q09665", "WBGene00006583", "O02159", "WBGene00020378", "G5EDZ8", "WBGene00000288", "Q94288", "WBGene00000287", "Q09980", "WBGene00017394", "O16305", "WBGene00000552", "G5EEG0", "WBGene00000286" ] }, "reaction_10504156": { "compartment": "compartment_70101", "id": "reaction_10504156", "reactome": "R-CEL-71552", "name": "limit dextrin-glycogenin => ((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl) glycogenin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10504128" ], "products": [ "species_10504148" ], "modifiers": [ [ "species_10504153", "catalyst" ] ], "additional_components": [ "H2KYQ5", "WBGene00006863", "species_266099", "G5ECZ5", "WBGene00011684", "O45819", "WBGene00012020", "G5ECZ5", "WBGene00011684", "H2KYQ5", "WBGene00006863", "O45819", "WBGene00012020", "species_266099", "WBGene00011050" ] }, "reaction_10503904": { "compartment": "compartment_70101", "id": "reaction_10503904", "reactome": "R-CEL-71299", "name": "6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29996", "species_29366" ], "products": [ "species_70106", "species_113528", "species_29364", "species_29732" ], "modifiers": [ [ "species_10503901", "catalyst" ] ], "additional_components": [ "Q17761", "WBGene00012015" ] }, "reaction_10570503": { "compartment": "compartment_70101", "id": "reaction_10570503", "reactome": "R-CEL-8982667", "name": "PGM2:Mg2+ isomerises dR1P to dR5P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6787326" ], "products": [ "species_6787328" ], "modifiers": [ [ "species_10502849", "catalyst" ] ], "additional_components": [ "species_114632", "O45934", "WBGene00012803" ] }, "reaction_10569995": { "compartment": "compartment_70101", "id": "reaction_10569995", "reactome": "R-CEL-8955844", "name": "RBKS phosphorylates ribose to R5P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_8955853" ], "products": [ "species_73578", "species_29370" ], "modifiers": [ [ "species_10569992", "catalyst" ] ], "additional_components": [ "WBGene00008548" ] }, "reaction_10558222": { "compartment": "compartment_70101", "id": "reaction_10558222", "reactome": "R-CEL-6787321", "name": "DERA cleaves dR5P to GA3P and CH3CHO", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6787328" ], "products": [ "species_29578", "species_29510" ], "modifiers": [ [ "species_10558219", "catalyst" ] ], "additional_components": [ "WBGene00017283" ] }, "reaction_10558225": { "compartment": "compartment_70101", "id": "reaction_10558225", "reactome": "R-CEL-6787329", "name": "PGM2:Mg2+ isomerises R1P to R5P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_112016" ], "products": [ "species_73578" ], "modifiers": [ [ "species_10502849", "catalyst" ] ], "additional_components": [ "species_114632", "O45934", "WBGene00012803" ] }, "reaction_10503924": { "compartment": "compartment_70101", "id": "reaction_10503924", "reactome": "R-CEL-71303", "name": "RPE dimers isomerise RU5P to XY5P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29732" ], "products": [ "species_29790" ], "modifiers": [ [ "species_10503921", "catalyst" ] ], "additional_components": [ "Q95ZW2", "WBGene00017272", "species_113531" ] }, "reaction_10506066": { "compartment": "compartment_70101", "id": "reaction_10506066", "reactome": "R-CEL-73580", "name": "D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73578", "species_113592" ], "products": [ "species_73566", "species_76577" ], "modifiers": [ [ "species_10506063", "catalyst" ] ], "additional_components": [ "Q6AHR3", "WBGene00020107" ] }, "reaction_10508824": { "compartment": "compartment_70101", "id": "reaction_10508824", "reactome": "R-CEL-111215", "name": "D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73578", "species_110644" ], "products": [ "species_73566", "species_109386" ], "modifiers": [ [ "species_10506063", "catalyst" ], [ "species_29926", "catalyst" ], [ "species_29372", "catalyst" ] ], "additional_components": [ "Q6AHR3", "WBGene00020107" ] }, "reaction_10512117": { "compartment": "compartment_70101", "id": "reaction_10512117", "reactome": "R-CEL-177784", "name": "ribose 5-phosphate <=> D-ribulose 5-phosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73578" ], "products": [ "species_29732" ], "modifiers": [ [ "species_10503929", "catalyst" ] ], "additional_components": [ "WBGene00015101" ] }, "reaction_10503894": { "compartment": "compartment_70101", "id": "reaction_10503894", "reactome": "R-CEL-71296", "name": "D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_31467" ], "products": [ "species_29996" ], "modifiers": [ [ "species_10503891", "catalyst" ] ], "additional_components": [ "WBGene00013301" ] }, "reaction_10514364": { "compartment": "compartment_70101", "id": "reaction_10514364", "reactome": "R-CEL-199803", "name": "xylulose 5-phosphate <=> D-ribulose 5-phosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29790" ], "products": [ "species_29732" ], "modifiers": [ [ "species_10503921", "catalyst" ] ], "additional_components": [ "Q95ZW2", "WBGene00017272", "species_113531" ] }, "reaction_10570173": { "compartment": "compartment_70101", "id": "reaction_10570173", "reactome": "R-CEL-8959719", "name": "SHPK phosphorylates Sedo to Sedo7P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_8959707" ], "products": [ "species_70106", "species_29370", "species_29882" ], "modifiers": [ [ "species_10570170", "catalyst" ] ], "additional_components": [ "WBGene00012017" ] }, "reaction_10503076": { "compartment": "compartment_70101", "id": "reaction_10503076", "reactome": "R-CEL-70479", "name": "D-fructose 1,6-bisphosphate + H2O => D-fructose 6-phosphate + orthophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30014", "species_29356" ], "products": [ "species_29372", "species_29512" ], "modifiers": [ [ "species_10503073", "catalyst" ], [ "species_76577", "inhibitor" ] ], "additional_components": [ "species_114632", "G5EBJ7", "WBGene00001404" ] }, "reaction_10513893": { "compartment": "compartment_70101", "id": "reaction_10513893", "reactome": "R-CEL-198508", "name": "malate + NAD+ <=> oxaloacetate + NADH + H+", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_198498", "species_29360" ], "products": [ "species_70106", "species_76213", "species_73473" ], "modifiers": [ [ "species_10513890", "catalyst" ] ], "additional_components": [ "Q9UAV5", "WBGene00018491" ] }, "reaction_10502823": { "compartment": "compartment_70101", "id": "reaction_10502823", "reactome": "R-CEL-70241", "name": "oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [cytosol]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_76213" ], "products": [ "species_29420", "species_113528", "species_29492" ], "modifiers": [ [ "species_10502820", "catalyst" ] ], "additional_components": [ "Q9TYQ8", "WBGene00019151", "O02286", "WBGene00011232", "O44906", "WBGene00021043" ] }, "reaction_10519528": { "compartment": "compartment_70101", "id": "reaction_10519528", "reactome": "R-CEL-376851", "name": "Exchange of alpha-ketoglutarate (2-oxoglutarate) and malate across the inner mitochondrial membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113594", "species_198498" ], "products": [ "species_29406", "species_113544" ], "modifiers": [ [ "species_10513880", "catalyst" ] ], "additional_components": [ "P90992", "WBGene00015186" ] }, "reaction_10513901": { "compartment": "compartment_70101", "id": "reaction_10513901", "reactome": "R-CEL-198513", "name": "Cytosolic glucose 6-phosphate is exchanged for orthophosphate from the endoplasmic reticulum lumen by SLC37A4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113551", "species_30537" ], "products": [ "species_29372", "species_113782" ], "modifiers": [ [ "species_10513898", "catalyst" ] ], "additional_components": [ "WBGene00302978" ] }, "reaction_10518414": { "compartment": "compartment_5460", "id": "reaction_10518414", "reactome": "R-CEL-372819", "name": "oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [mitochondrial matrix]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113573", "species_113587" ], "products": [ "species_372364", "species_113525", "species_29376" ], "modifiers": [ [ "species_10518411", "catalyst" ] ], "additional_components": [ "WBGene00011232" ] }, "reaction_10503122": { "compartment": "compartment_5460", "id": "reaction_10503122", "reactome": "R-CEL-70501", "name": "Pyruvate + CO2 + ATP => ADP + Orthophosphate + Oxaloacetate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113593", "species_113557", "species_29376" ], "products": [ "species_113548", "species_113581", "species_113587" ], "modifiers": [ [ "species_10503119", "catalyst" ], [ "species_113559", "catalyst" ] ], "additional_components": [ "species_266099", "O17732", "WBGene00004258", "species_199207" ] }, "reaction_10518291": { "compartment": "compartment_70101", "id": "reaction_10518291", "reactome": "R-CEL-372449", "name": "phosphoenolpyruvate [mitochondrial matrix] + citrate [cytosol] => phosphoenolpyruvate [cytosol] + citrate [mitochondrial matrix]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76190", "species_372364" ], "products": [ "species_29654", "species_29492" ], "modifiers": [ [ "species_10507389", "catalyst" ] ], "additional_components": [ "WBGene00010780" ] }, "reaction_10518422": { "compartment": "compartment_70101", "id": "reaction_10518422", "reactome": "R-CEL-372843", "name": "malate [mitochondrial matrix] + orthophosphate [cytosol] <=> malate [cytosol] + orthophosphate [mitochondrial matrix]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29372", "species_113544" ], "products": [ "species_113548", "species_198498" ], "modifiers": [ [ "species_10518419", "catalyst" ] ], "additional_components": [ "WBGene00019656" ] }, "reaction_10513883": { "compartment": "compartment_70101", "id": "reaction_10513883", "reactome": "R-CEL-198440", "name": "malate [mitochondrial matrix] + alpha-ketoglutarate [cytosol] <=> malate [cytosol] + alpha-ketoglutarate [mitochondrial matrix]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29406", "species_113544" ], "products": [ "species_113594", "species_198498" ], "modifiers": [ [ "species_10513880", "catalyst" ] ], "additional_components": [ "P90992", "WBGene00015186" ] }, "reaction_10571905": { "compartment": "compartment_17963", "id": "reaction_10571905", "reactome": "R-CEL-9603986", "name": "FUT3 transfers Fuc to Type 1 chains to form LeA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9036984", "species_205683" ], "products": [ "species_205689", "species_9605607" ], "modifiers": [ [ "species_10557156", "catalyst" ] ], "additional_components": [ "WBGene00016163" ] }, "reaction_10571890": { "compartment": "compartment_17963", "id": "reaction_10571890", "reactome": "R-CEL-9603982", "name": "FUT2 transfers Fuc to LeA to form LeB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9605607", "species_205683" ], "products": [ "species_205689", "species_9605394" ], "modifiers": [ [ "species_10571827", "catalyst" ] ], "additional_components": [ "WBGene00015019" ] }, "reaction_10571973": { "compartment": "compartment_17963", "id": "reaction_10571973", "reactome": "R-CEL-9605682", "name": "FUT3,5,6,7 transfers Fuc to Type 2 MSGG to form sLeX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9605685", "species_205683" ], "products": [ "species_9605661", "species_205689" ], "modifiers": [ [ "species_10571970", "catalyst" ] ], "additional_components": [ "Q18255", "WBGene00016163" ] }, "reaction_10571892": { "compartment": "compartment_17963", "id": "reaction_10571892", "reactome": "R-CEL-9603983", "name": "FUT2 transfers Fuc to LeX to form LeY", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9605593", "species_205683" ], "products": [ "species_205689", "species_9605586" ], "modifiers": [ [ "species_10571827", "catalyst" ] ], "additional_components": [ "WBGene00015019" ] }, "reaction_10571946": { "compartment": "compartment_17963", "id": "reaction_10571946", "reactome": "R-CEL-9603989", "name": "B3GALTs transfer Gal to GlcNAc-1,3-Gal-R to form Type 1 chain", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9604808", "species_735682" ], "products": [ "species_205687", "species_9036984" ], "modifiers": [ [ "species_10571943", "catalyst" ] ], "additional_components": [ "Q95US5", "WBGene00000270", "Q9XU74", "WBGene00011780", "G5EDB3", "WBGene00044630", "G5ECA6", "WBGene00011780", "H2L0F4", "WBGene00044618", "O02231", "WBGene00011780", "O02310", "WBGene00011780", "O17750", "WBGene00011780", "O62114", "WBGene00011780", "O62115", "WBGene00011780", "O62163", "WBGene00011780", "O62165", "WBGene00011780", "O62375", "WBGene00011780", "Q20575", "WBGene00011780", "Q6QMT2", "WBGene00000267", "Q8MQG4", "WBGene00011780" ] }, "reaction_10571964": { "compartment": "compartment_17963", "id": "reaction_10571964", "reactome": "R-CEL-9605609", "name": "FUT3 transfers Fuc to Type 1 MSGG to form sLeA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9605595", "species_205683" ], "products": [ "species_9605615", "species_205689" ], "modifiers": [ [ "species_10557156", "catalyst" ] ], "additional_components": [ "WBGene00016163" ] }, "reaction_10571903": { "compartment": "compartment_17963", "id": "reaction_10571903", "reactome": "R-CEL-9603984", "name": "FUT4,5,9,(10,11) transfer Fuc to Type 2 chains to form LeX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9033790", "species_205683" ], "products": [ "species_9605593", "species_205689" ], "modifiers": [ [ "species_10571900", "catalyst" ] ], "additional_components": [ "Q18255", "WBGene00016163" ] }, "reaction_10571966": { "compartment": "compartment_17963", "id": "reaction_10571966", "reactome": "R-CEL-9605644", "name": "FUT3 transfers Fuc to Type 1 DSGG to form dsLeA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9605649", "species_205683" ], "products": [ "species_205689", "species_9605651" ], "modifiers": [ [ "species_10557156", "catalyst" ] ], "additional_components": [ "WBGene00016163" ] }, "reaction_10510218": { "compartment": "compartment_7660", "id": "reaction_10510218", "reactome": "R-CEL-163664", "name": "AMP binds to gamma subunit of AMP kinase heterotrimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_164121", "species_10510212" ], "products": [ "species_10510216" ], "modifiers": [], "additional_components": [ "Q9N501", "WBGene00021527", "A0A1T5HUK9", "WBGene00013732", "H2L0K0", "WBGene00020135", "O02168", "WBGene00020633", "Q95ZQ4", "WBGene00020142", "Q9XUY2", "WBGene00010115", "Q9N501", "WBGene00021527", "A0A1T5HUK9", "WBGene00013732", "H2L0K0", "WBGene00020135", "O02168", "WBGene00020633", "species_76577", "Q95ZQ4", "WBGene00020142", "Q9XUY2", "WBGene00010115" ] }, "reaction_10517761": { "compartment": "compartment_876", "id": "reaction_10517761", "reactome": "R-CEL-265645", "name": "Calcium Influx through Voltage-gated Calcium Channels", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74112" ], "products": [ "species_74016" ], "modifiers": [ [ "species_10517758", "catalyst" ] ], "additional_components": [ "G5EG74", "WBGene00007041", "P34374", "WBGene00006772", "Q8MQA1", "WBGene00001187", "A0A3B1E663", "WBGene00006742" ] }, "reaction_10527093": { "compartment": "compartment_876", "id": "reaction_10527093", "reactome": "R-CEL-499981", "name": "Transport of Extracellular Glucose to the Cytosol by GLUT1 and GLUT2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70115" ], "products": [ "species_70113" ], "modifiers": [ [ "species_10527090", "catalyst" ] ], "additional_components": [ "Q23626", "WBGene00022014", "Q95QY6", "WBGene00022014", "Q9GPA2", "WBGene00022014", "Q9N309", "WBGene00022014", "Q9U2K5", "WBGene00022014", "Q9XU83", "WBGene00022014", "Q9XVL3", "WBGene00022014", "G5EC93", "WBGene00022014", "O16547", "WBGene00022014", "O44616", "WBGene00022014", "O44827", "WBGene00019207", "O45920", "WBGene00022014", "Q11114", "WBGene00022014", "Q19376", "WBGene00022014", "Q20734", "WBGene00022014", "Q23535", "WBGene00006865", "Q21381", "WBGene00043980", "Q9GYQ1", "WBGene00043980", "Q21382", "WBGene00043980", "Q9NEI8", "WBGene00043980", "Q21385", "WBGene00043980", "Q5WRR9", "WBGene00043980" ] }, "reaction_10510248": { "compartment": "compartment_7660", "id": "reaction_10510248", "reactome": "R-CEL-163743", "name": "Transcriptional activation of Acetyl-CoA carboxylase by ChREBP:MLX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [], "products": [ "species_10510246" ], "modifiers": [ [ "species_10510237", "catalyst" ] ], "additional_components": [ "Q9XUC3", "WBGene00012131", "H2L0M0", "WBGene00004076", "P41846", "WBGene00003378", "Q9TZ70", "WBGene00003510" ] }, "reaction_10510250": { "compartment": "compartment_7660", "id": "reaction_10510250", "reactome": "R-CEL-163748", "name": "Transcriptional activation of GP-acyl transferase gene by ChREBP:MLX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [], "products": [ "species_10507496" ], "modifiers": [ [ "species_10510237", "catalyst" ] ], "additional_components": [ "Q22267", "WBGene00011543", "Q93841", "WBGene00010339", "P41846", "WBGene00003378", "Q9TZ70", "WBGene00003510" ] }, "reaction_10510239": { "compartment": "compartment_7660", "id": "reaction_10510239", "reactome": "R-CEL-163733", "name": "Transcriptional activation of FAS monomer gene by ChREBP:MLX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [], "products": [ "species_10507450" ], "modifiers": [ [ "species_10510237", "catalyst" ] ], "additional_components": [ "WBGene00009342", "P41846", "WBGene00003378", "Q9TZ70", "WBGene00003510" ] }, "reaction_10568065": { "compartment": "compartment_70101", "id": "reaction_10568065", "reactome": "R-CEL-8932851", "name": "PQLC2 transports L-Arg,L-His,L-Lys from lysosomal lumen to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8932838" ], "products": [ "species_8932842" ], "modifiers": [ [ "species_10568062", "catalyst" ] ], "additional_components": [ "species_29612", "species_29444", "species_29468", "species_29468", "species_29612", "species_29444", "WBGene00021546" ] }, "reaction_10551456": { "compartment": "compartment_70101", "id": "reaction_10551456", "reactome": "R-CEL-5336453", "name": "NIPAs transport Mg2+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_114632" ], "products": [ "species_29926" ], "modifiers": [ [ "species_10551447", "catalyst" ] ], "additional_components": [ "WBGene00021820" ] }, "reaction_10551488": { "compartment": "compartment_70101", "id": "reaction_10551488", "reactome": "R-CEL-5340130", "name": "CTNS cotransports CySS-, H+ from lysosomal lumen to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428040", "species_5673778" ], "products": [ "species_70106", "species_379444" ], "modifiers": [ [ "species_10551485", "catalyst" ] ], "additional_components": [ "WBGene00008052" ] }, "reaction_10550773": { "compartment": "compartment_70101", "id": "reaction_10550773", "reactome": "R-CEL-5226999", "name": "ADD1:ADD3 binds DMTN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10550757", "species_10550769" ], "products": [ "species_10550771" ], "modifiers": [], "additional_components": [ "WBGene00006839", "Q20952", "WBGene00000073", "Q9U9K0", "WBGene00000072", "Q20952", "WBGene00000073", "Q9U9K0", "WBGene00000072", "Q95QM5", "WBGene00006839" ] }, "reaction_10550761": { "compartment": "compartment_70101", "id": "reaction_10550761", "reactome": "R-CEL-5226979", "name": "ADD1:ADD2 binds DMTN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10550757", "species_10550752" ], "products": [ "species_10550759" ], "modifiers": [], "additional_components": [ "WBGene00006839", "Q20952", "WBGene00000073", "Q9U9K0", "WBGene00000072", "Q20952", "WBGene00000073", "Q9U9K0", "WBGene00000072", "Q95QM5", "WBGene00006839" ] }, "reaction_10551480": { "compartment": "compartment_70101", "id": "reaction_10551480", "reactome": "R-CEL-5339538", "name": "MAGT1 transports Mg2+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_114632" ], "products": [ "species_29926" ], "modifiers": [ [ "species_10551477", "catalyst" ] ], "additional_components": [ "WBGene00022793" ] }, "reaction_10551467": { "compartment": "compartment_70101", "id": "reaction_10551467", "reactome": "R-CEL-5339528", "name": "TUSC3 transports Mg2+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_114632" ], "products": [ "species_29926" ], "modifiers": [ [ "species_10551464", "catalyst" ] ], "additional_components": [ "WBGene00022793" ] }, "reaction_10509864": { "compartment": "compartment_7660", "id": "reaction_10509864", "reactome": "R-CEL-156678", "name": "Activation of Cdc25C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10509856" ], "products": [ "species_29370", "species_10509859" ], "modifiers": [ [ "species_10509861", "catalyst" ] ], "additional_components": [ "WBGene00000389", "WBGene00000389", "WBGene00004043" ] }, "reaction_10510078": { "compartment": "compartment_7660", "id": "reaction_10510078", "reactome": "R-CEL-162657", "name": "Inactivation of Myt1 kinase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10510073" ], "products": [ "species_113582", "species_10510076" ], "modifiers": [ [ "species_10509851", "catalyst" ] ], "additional_components": [ "WBGene00006940", "WBGene00006940", "WBGene00004043" ] }, "reaction_10555392": { "compartment": "compartment_70101", "id": "reaction_10555392", "reactome": "R-CEL-5678863", "name": "CFTR transports Cl- from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_352022" ], "products": [ "species_188972", "species_29372", "species_29370" ], "modifiers": [ [ "species_10520442", "catalyst" ] ], "additional_components": [ "Q19625", "WBGene00003412", "Q95QV2", "WBGene00000477" ] }, "reaction_10534309": { "compartment": "compartment_70101", "id": "reaction_10534309", "reactome": "R-CEL-1454916", "name": "The ABCC family mediates organic anion transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_1454930" ], "products": [ "species_29372", "species_29370", "species_1454919" ], "modifiers": [ [ "species_10534306", "catalyst" ] ], "additional_components": [ "G5EE72", "WBGene00003411", "Q19625", "WBGene00003412", "Q95QV2", "WBGene00000477", "Q3S1M2", "WBGene00003407", "Q20943", "WBGene00003408", "G5EFP3", "WBGene00003410", "Q9U2G5", "WBGene00003413", "Q19048", "WBGene00003409", "Q9XW61", "WBGene00003414" ] }, "reaction_10566312": { "compartment": "compartment_12045", "id": "reaction_10566312", "reactome": "R-CEL-8866542", "name": "VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_10566310" ], "products": [ "species_10566284", "species_29372", "species_29370", "species_10566308" ], "modifiers": [], "additional_components": [ "Q93561", "WBGene00000843", "A3QMC6", "WBGene00016592", "G5EFG0", "WBGene00004759", "Q09396", "WBGene00018611", "Q9NF22", "WBGene00013667", "Q09463", "WBGene00004381", "P54812", "WBGene00008053", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "Q19625", "WBGene00003412", "Q95QV2", "WBGene00000477", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "Q19625", "WBGene00003412", "Q95QV2", "WBGene00000477", "Q93561", "WBGene00000843", "A3QMC6", "WBGene00016592", "G5EFG0", "WBGene00004759", "Q09396", "WBGene00018611", "Q9NF22", "WBGene00013667", "Q09463", "WBGene00004381", "P54812", "WBGene00008053" ] }, "reaction_10517776": { "compartment": "compartment_876", "id": "reaction_10517776", "reactome": "R-CEL-265783", "name": "ABCG5:ABCG8 transports sterols from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_265784", "species_113592" ], "products": [ "species_29372", "species_29370", "species_265781" ], "modifiers": [ [ "species_10517773", "catalyst" ] ], "additional_components": [ "CHEBI:26125", "species_193384", "CHEBI:26125", "species_193384", "Q18900", "WBGene00016973", "D7SFK1", "WBGene00006522" ] }, "reaction_10520430": { "compartment": "compartment_17947", "id": "reaction_10520430", "reactome": "R-CEL-382613", "name": "PEX-19 docks ABCD1/D2/D3 to peroximal membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10520428", "species_10520404" ], "products": [ "species_10520396", "species_10520426", "species_10520404" ], "modifiers": [], "additional_components": [ "O45730", "WBGene00004061", "Q18598", "WBGene00004059", "P34453", "WBGene00004201", "WBGene00004193", "O45730", "WBGene00004061", "Q18598", "WBGene00004059", "WBGene00004201", "WBGene00004193" ] }, "reaction_10520399": { "compartment": "compartment_17947", "id": "reaction_10520399", "reactome": "R-CEL-382575", "name": "ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_382577" ], "products": [ "species_382571", "species_29372", "species_29370" ], "modifiers": [ [ "species_10520396", "catalyst" ] ], "additional_components": [ "O45730", "WBGene00004061", "Q18598", "WBGene00004059" ] }, "reaction_10550732": { "compartment": "compartment_70101", "id": "reaction_10550732", "reactome": "R-CEL-5223317", "name": "ABCB9 transports peptides from cytosol to lysosomal lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_5223341" ], "products": [ "species_5223344", "species_29372", "species_29370" ], "modifiers": [ [ "species_10550729", "catalyst" ] ], "additional_components": [ "O02086", "WBGene00001812" ] }, "reaction_10566317": { "compartment": "compartment_12045", "id": "reaction_10566317", "reactome": "R-CEL-8866546", "name": "RNF5 and RNF185 ubiquitinate misfolded CFTR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10566314", "species_10502375" ], "products": [ "species_10566310" ], "modifiers": [ [ "species_10566314", "catalyst" ] ], "additional_components": [ "Q93561", "WBGene00000843", "A3QMC6", "WBGene00016592", "G5EFG0", "WBGene00004759", "Q09396", "WBGene00018611", "Q9NF22", "WBGene00013667", "Q09463", "WBGene00004381", "P54812", "WBGene00008053", "Q19625", "WBGene00003412", "Q95QV2", "WBGene00000477", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "Q93561", "WBGene00000843", "A3QMC6", "WBGene00016592", "G5EFG0", "WBGene00004759", "Q09396", "WBGene00018611", "Q9NF22", "WBGene00013667", "Q09463", "WBGene00004381", "P54812", "WBGene00008053", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "Q19625", "WBGene00003412", "Q95QV2", "WBGene00000477", "Q93561", "WBGene00000843", "A3QMC6", "WBGene00016592", "G5EFG0", "WBGene00004759", "Q09396", "WBGene00018611", "Q9NF22", "WBGene00013667", "Q09463", "WBGene00004381", "P54812", "WBGene00008053", "Q19625", "WBGene00003412", "Q95QV2", "WBGene00000477" ] }, "reaction_10520374": { "compartment": "compartment_70616", "id": "reaction_10520374", "reactome": "R-CEL-382560", "name": "ABC7, mABC1 and mABC2 mediate heme transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113593", "species_189444", "species_113521" ], "products": [ "species_113548", "species_113581", "species_71185" ], "modifiers": [ [ "species_10520371", "catalyst" ] ], "additional_components": [ "G4SRS5", "WBGene00022281" ] }, "reaction_10533110": { "compartment": "compartment_17906", "id": "reaction_10533110", "reactome": "R-CEL-1369065", "name": "ABCB6 transports porphyrin from cytosol to mitchondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1369066", "species_29356", "species_113592" ], "products": [ "species_29372", "species_29370", "species_1369027" ], "modifiers": [ [ "species_10533107", "catalyst" ] ], "additional_components": [ "G5EFD4", "WBGene00001815" ] }, "reaction_10566319": { "compartment": "compartment_12045", "id": "reaction_10566319", "reactome": "R-CEL-8866551", "name": "CFTR binds components of the ERAD machinery for ubiquitination and degradation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10566282", "species_10566308" ], "products": [ "species_10566314" ], "modifiers": [], "additional_components": [ "Q19625", "WBGene00003412", "Q95QV2", "WBGene00000477", "Q93561", "WBGene00000843", "A3QMC6", "WBGene00016592", "G5EFG0", "WBGene00004759", "Q09396", "WBGene00018611", "Q9NF22", "WBGene00013667", "Q09463", "WBGene00004381", "P54812", "WBGene00008053", "Q93561", "WBGene00000843", "A3QMC6", "WBGene00016592", "G5EFG0", "WBGene00004759", "Q09396", "WBGene00018611", "Q9NF22", "WBGene00013667", "Q09463", "WBGene00004381", "P54812", "WBGene00008053", "Q19625", "WBGene00003412", "Q95QV2", "WBGene00000477" ] }, "reaction_10566321": { "compartment": "compartment_70101", "id": "reaction_10566321", "reactome": "R-CEL-8866553", "name": "misfolded CFTR is degraded by the 26S proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10566284" ], "products": [ "species_10502375" ], "modifiers": [ [ "species_10502572", "catalyst" ] ], "additional_components": [ "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "Q19625", "WBGene00003412", "Q95QV2", "WBGene00000477", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "P91477", "WBGene00003950", "Q95PZ7", "WBGene00013435", "Q18115", "WBGene00004459", "O62102", "WBGene00003948", "O17071", "WBGene00004504", "Q10920", "WBGene00016623", "P34286", "WBGene00003952", "Q9XTT9", "WBGene00004506", "Q23449", "WBGene00004468", "Q95005", "WBGene00003925", "P46502", "WBGene00004503", "O61792", "WBGene00004464", "O17586", "WBGene00003922", "O76371", "WBGene00004505", "Q20585", "WBGene00004463", "Q95008", "WBGene00003926", "Q18787", "WBGene00004501", "Q20058", "WBGene00009445", "Q9N599", "WBGene00003924", "O16368", "WBGene00004502", "O61742", "WBGene00004466", "Q09583", "WBGene00003928", "Q966I8", "WBGene00003947", "Q04908", "WBGene00004460", "Q9XUV0", "WBGene00003951", "Q27488", "WBGene00003923", "Q9GZH5", "WBGene00004458", "O44156", "WBGene00003927", "Q22253", "WBGene00004465", "O76577", "WBGene00004467", "P90868", "WBGene00003953", "Q19324", "WBGene00004461", "Q17971", "WBGene00007588", "Q23237", "WBGene00003949", "Q20938", "WBGene00004462" ] }, "reaction_10534322": { "compartment": "compartment_876", "id": "reaction_10534322", "reactome": "R-CEL-1467457", "name": "ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_1131652" ], "products": [ "species_29372", "species_29370", "species_1467459" ], "modifiers": [ [ "species_10534319", "catalyst" ] ], "additional_components": [ "P34712", "WBGene00003995", "G5EG58", "WBGene00004003" ] }, "reaction_10555389": { "compartment": "compartment_984", "id": "reaction_10555389", "reactome": "R-CEL-5678706", "name": "ABCB4 transports PC from plasma membrane to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_429802", "species_113592" ], "products": [ "species_382539", "species_29372", "species_29370" ], "modifiers": [ [ "species_10555386", "catalyst" ] ], "additional_components": [ "G5EG58", "WBGene00004003", "P34712", "WBGene00003995" ] }, "reaction_10566333": { "compartment": "compartment_876", "id": "reaction_10566333", "reactome": "R-CEL-8866851", "name": "CFTR transits to the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10566282" ], "products": [ "species_10520442" ], "modifiers": [], "additional_components": [ "Q19625", "WBGene00003412", "Q95QV2", "WBGene00000477", "Q19625", "WBGene00003412", "Q95QV2", "WBGene00000477" ] }, "reaction_10520445": { "compartment": "compartment_876", "id": "reaction_10520445", "reactome": "R-CEL-383190", "name": "HCO3- transport through ion channel", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_111627", "species_113592" ], "products": [ "species_29372", "species_29370", "species_425425" ], "modifiers": [ [ "species_10520442", "catalyst" ] ], "additional_components": [ "Q19625", "WBGene00003412", "Q95QV2", "WBGene00000477" ] }, "reaction_10550782": { "compartment": "compartment_70101", "id": "reaction_10550782", "reactome": "R-CEL-5227009", "name": "ABCF1 binds EIF2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10505631", "species_10550778" ], "products": [ "species_10550780" ], "modifiers": [], "additional_components": [ "Q9BKU3", "WBGene00021351", "Q21230", "WBGene00010560", "Q95XR0", "WBGene00021466", "WBGene00006512", "Q19554", "WBGene00006512", "Q9BKU3", "WBGene00021351", "Q21230", "WBGene00010560", "Q95XR0", "WBGene00021466" ] }, "reaction_10518493": { "compartment": "compartment_70101", "id": "reaction_10518493", "reactome": "R-CEL-373705", "name": "Caspase cleavage of DCC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10518486" ], "products": [ "species_10518490", "species_10518488" ], "modifiers": [ [ "species_10509422", "catalyst" ] ], "additional_components": [ "P42573", "WBGene00000417" ] }, "reaction_10556804": { "compartment": "compartment_70101", "id": "reaction_10556804", "reactome": "R-CEL-5691108", "name": "SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502375", "species_10556692" ], "products": [ "species_10556795" ], "modifiers": [ [ "species_10556801", "catalyst" ] ], "additional_components": [ "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "WBGene00000040", "WBGene00000040", "Q93725", "WBGene00003587", "G5ECU1", "WBGene00004807", "Q17389", "WBGene00000836" ] }, "reaction_10535239": { "compartment": "compartment_70101", "id": "reaction_10535239", "reactome": "R-CEL-1562626", "name": "Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_71067", "species_29368" ], "products": [ "species_5691103" ], "modifiers": [ [ "species_10535236", "catalyst" ] ], "additional_components": [ "O16453", "WBGene00001500", "Q9TYS3", "WBGene00001501" ] }, "reaction_10556813": { "compartment": "compartment_70101", "id": "reaction_10556813", "reactome": "R-CEL-5691131", "name": "CANDI binds CUL1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10516329", "species_10556809" ], "products": [ "species_10556811" ], "modifiers": [], "additional_components": [ "WBGene00000836", "WBGene00013606", "G5ED41", "WBGene00013606", "Q17389", "WBGene00000836" ] }, "reaction_10529202": { "compartment": "compartment_984", "id": "reaction_10529202", "reactome": "R-CEL-917805", "name": "CYBRD1:Heme reduces Fe3+ to Fe2+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_917828", "species_912516" ], "products": [ "species_435347" ], "modifiers": [ [ "species_10529199", "catalyst" ] ], "additional_components": [ "species_71185", "O16271", "WBGene00018210" ] }, "reaction_10556690": { "compartment": "compartment_70101", "id": "reaction_10556690", "reactome": "R-CEL-5690873", "name": "ACO1 binds 4Fe-4S", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10556686", "species_5690881" ], "products": [ "species_10556688" ], "modifiers": [], "additional_components": [ "WBGene00000040", "Q23500", "WBGene00000040" ] }, "reaction_10556695": { "compartment": "compartment_70101", "id": "reaction_10556695", "reactome": "R-CEL-5690911", "name": "ACO1:4Fe-4S isomerises CIT to ISCIT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76190" ], "products": [ "species_389545" ], "modifiers": [ [ "species_10556688", "catalyst" ] ], "additional_components": [ "Q23500", "WBGene00000040" ] }, "reaction_10556792": { "compartment": "compartment_5460", "id": "reaction_10556792", "reactome": "R-CEL-5691107", "name": "FTMT 24mer oxidises 4Fe2+ to 4Fe(3+)O(OH)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113533", "species_113531", "species_113529" ], "products": [ "species_5691135" ], "modifiers": [ [ "species_10556789", "catalyst" ] ], "additional_components": [ "Q9TYS3", "WBGene00001501", "O16453", "WBGene00001500" ] }, "reaction_10529210": { "compartment": "compartment_947586", "id": "reaction_10529210", "reactome": "R-CEL-917891", "name": "SLC40A1:CP:6Cu2+ oxidises Fe2+ to Fe3+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_435347", "species_352327" ], "products": [ "species_109276", "species_912516" ], "modifiers": [ [ "species_10528427", "catalyst" ] ], "additional_components": [ "Q19687", "WBGene00009008", "species_209799", "O44607", "WBGene00019977", "Q8IA95", "WBGene00021354" ] }, "reaction_10529213": { "compartment": "compartment_947586", "id": "reaction_10529213", "reactome": "R-CEL-917933", "name": "SLC40A1:HEPH:6Cu2+ oxidises 4Fe2+ to 4Fe3+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_435347", "species_352327" ], "products": [ "species_109276", "species_912516" ], "modifiers": [ [ "species_10524363", "catalyst" ] ], "additional_components": [ "O44607", "WBGene00019977", "Q8IA95", "WBGene00021354", "CHEBI:28694", "Q19687", "WBGene00009008" ] }, "reaction_10534717": { "compartment": "compartment_70101", "id": "reaction_10534717", "reactome": "R-CEL-1475435", "name": "CA1:Zn2+,CA2:Zn2+ hydrate CO2 to HCO3-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113528" ], "products": [ "species_70106", "species_111627" ], "modifiers": [ [ "species_10534714", "catalyst" ] ], "additional_components": [ "O02637", "WBGene00000284", "Q10462", "WBGene00000283", "Q21614", "WBGene00000282", "Q27504", "WBGene00000281", "species_216785" ] }, "reaction_10570305": { "compartment": "compartment_70101", "id": "reaction_10570305", "reactome": "R-CEL-8981570", "name": "GLUT4 (SLC2A4) tetramer transports Glc from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70115" ], "products": [ "species_70113" ], "modifiers": [ [ "species_10570302", "catalyst" ] ], "additional_components": [ "O44827", "WBGene00019207" ] }, "reaction_10551459": { "compartment": "compartment_70101", "id": "reaction_10551459", "reactome": "R-CEL-5339524", "name": "GLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70115" ], "products": [ "species_70113" ], "modifiers": [ [ "species_10525428", "catalyst" ], [ "species_113592", "inhibitor" ] ], "additional_components": [ "Q21381", "WBGene00043980", "Q9GYQ1", "WBGene00043980", "Q21382", "WBGene00043980", "Q9NEI8", "WBGene00043980", "Q21385", "WBGene00043980", "Q5WRR9", "WBGene00043980" ] }, "reaction_10570307": { "compartment": "compartment_70101", "id": "reaction_10570307", "reactome": "R-CEL-8981574", "name": "GLUT2 (SLC2A2) tetramer transports Glc from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70115" ], "products": [ "species_70113" ], "modifiers": [ [ "species_10512849", "catalyst" ] ], "additional_components": [ "Q23626", "WBGene00022014", "Q95QY6", "WBGene00022014", "Q9GPA2", "WBGene00022014", "Q9N309", "WBGene00022014", "Q9U2K5", "WBGene00022014", "Q9XU83", "WBGene00022014", "Q9XVL3", "WBGene00022014", "G5EC93", "WBGene00022014", "O16547", "WBGene00022014", "O44616", "WBGene00022014", "O44827", "WBGene00019207", "O45920", "WBGene00022014", "Q11114", "WBGene00022014", "Q19376", "WBGene00022014", "Q20734", "WBGene00022014", "Q23535", "WBGene00006865" ] }, "reaction_10570293": { "compartment": "compartment_70101", "id": "reaction_10570293", "reactome": "R-CEL-8981553", "name": "GLUT14 (SLC2A14) tetramer transports Glc from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70115" ], "products": [ "species_70113" ], "modifiers": [ [ "species_10570290", "catalyst" ] ], "additional_components": [ "Q21381", "WBGene00043980", "Q21382", "WBGene00043980", "Q21385", "WBGene00043980", "Q5WRR9", "WBGene00043980", "Q9GYQ1", "WBGene00043980", "Q9NEI8", "WBGene00043980" ] }, "reaction_10523383": { "compartment": "compartment_876", "id": "reaction_10523383", "reactome": "R-CEL-429036", "name": "SLC2A9 transports Fru, Glc, urate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_429078" ], "products": [ "species_429148" ], "modifiers": [ [ "species_10523380", "catalyst" ] ], "additional_components": [ "species_70113", "species_30034", "species_29532", "species_70113", "species_30034", "species_29532", "Q19376", "WBGene00022014", "Q20734", "WBGene00022014", "Q23535", "WBGene00006865", "Q23626", "WBGene00022014", "Q95QY6", "WBGene00022014", "Q9GPA2", "WBGene00022014", "Q9N309", "WBGene00022014", "Q9U2K5", "WBGene00022014", "Q9XU83", "WBGene00022014", "Q9XVL3", "WBGene00022014", "G5EC93", "WBGene00022014", "O16547", "WBGene00022014", "O44616", "WBGene00022014", "O44827", "WBGene00019207", "O45920", "WBGene00022014", "Q11114", "WBGene00022014" ] }, "reaction_10523335": { "compartment": "compartment_876", "id": "reaction_10523335", "reactome": "R-CEL-428779", "name": "GLUT7 and GLUT11 transport glucose and fructose", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428819" ], "products": [ "species_428802" ], "modifiers": [ [ "species_10523332", "catalyst" ] ], "additional_components": [ "species_70113", "species_29532", "species_70113", "species_29532", "G5EC93", "WBGene00022014", "O16547", "WBGene00022014", "O44616", "WBGene00022014", "O44827", "WBGene00019207", "O45920", "WBGene00022014", "Q11114", "WBGene00022014", "Q19376", "WBGene00022014", "Q20734", "WBGene00022014", "Q23535", "WBGene00006865", "Q23626", "WBGene00022014", "Q95QY6", "WBGene00022014", "Q9GPA2", "WBGene00022014", "Q9N309", "WBGene00022014", "Q9U2K5", "WBGene00022014", "Q9XU83", "WBGene00022014", "Q9XVL3", "WBGene00022014" ] }, "reaction_10525432": { "compartment": "compartment_70101", "id": "reaction_10525432", "reactome": "R-CEL-450088", "name": "GLUT1 tetramer binds 4xATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10525428" ], "products": [ "species_10525430" ], "modifiers": [], "additional_components": [ "Q21381", "WBGene00043980", "Q9GYQ1", "WBGene00043980", "Q21382", "WBGene00043980", "Q9NEI8", "WBGene00043980", "Q21385", "WBGene00043980", "Q5WRR9", "WBGene00043980", "Q21381", "WBGene00043980", "Q9GYQ1", "WBGene00043980", "Q21382", "WBGene00043980", "Q9NEI8", "WBGene00043980", "Q21385", "WBGene00043980", "Q5WRR9", "WBGene00043980", "species_29358" ] }, "reaction_10525434": { "compartment": "compartment_70101", "id": "reaction_10525434", "reactome": "R-CEL-450092", "name": "GLUT1:ATP tetramer dissociates to GLUT1 tetramer and 4xATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10525430" ], "products": [ "species_113592", "species_10525428" ], "modifiers": [], "additional_components": [ "Q21381", "WBGene00043980", "Q9GYQ1", "WBGene00043980", "Q21382", "WBGene00043980", "Q9NEI8", "WBGene00043980", "Q21385", "WBGene00043980", "Q5WRR9", "WBGene00043980", "species_29358", "Q21381", "WBGene00043980", "Q9GYQ1", "WBGene00043980", "Q21382", "WBGene00043980", "Q9NEI8", "WBGene00043980", "Q21385", "WBGene00043980", "Q5WRR9", "WBGene00043980" ] }, "reaction_10570298": { "compartment": "compartment_70101", "id": "reaction_10570298", "reactome": "R-CEL-8981564", "name": "GLUT3 (SLC2A3) tetramer transports Glc from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70115" ], "products": [ "species_70113" ], "modifiers": [ [ "species_10570295", "catalyst" ] ], "additional_components": [ "Q9NEI8", "WBGene00043980" ] }, "reaction_10525437": { "compartment": "compartment_70101", "id": "reaction_10525437", "reactome": "R-CEL-450095", "name": "GLUT2 (SLC2A2) transports Glc from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70113" ], "products": [ "species_70115" ], "modifiers": [ [ "species_10512849", "catalyst" ] ], "additional_components": [ "Q23626", "WBGene00022014", "Q95QY6", "WBGene00022014", "Q9GPA2", "WBGene00022014", "Q9N309", "WBGene00022014", "Q9U2K5", "WBGene00022014", "Q9XU83", "WBGene00022014", "Q9XVL3", "WBGene00022014", "G5EC93", "WBGene00022014", "O16547", "WBGene00022014", "O44616", "WBGene00022014", "O44827", "WBGene00019207", "O45920", "WBGene00022014", "Q11114", "WBGene00022014", "Q19376", "WBGene00022014", "Q20734", "WBGene00022014", "Q23535", "WBGene00006865" ] }, "reaction_10522496": { "compartment": "compartment_876", "id": "reaction_10522496", "reactome": "R-CEL-425678", "name": "SLC24A1-4 exchange extracellular 4Na+ for cytosolic Ca2+, K+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804", "species_74016", "species_74113" ], "products": [ "species_74126", "species_83910", "species_74112" ], "modifiers": [ [ "species_10522493", "catalyst" ] ], "additional_components": [ "G5EC02", "WBGene00003570", "P90858", "WBGene00003569" ] }, "reaction_10522504": { "compartment": "compartment_876", "id": "reaction_10522504", "reactome": "R-CEL-425822", "name": "K+-independent Li+/Ca2+ exchanger transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_425815", "species_74016" ], "products": [ "species_425810", "species_74112" ], "modifiers": [ [ "species_10522501", "catalyst" ] ], "additional_components": [ "WBGene00003572" ] }, "reaction_10522595": { "compartment": "compartment_876", "id": "reaction_10522595", "reactome": "R-CEL-425994", "name": "Na+/H+ exchanger transport (at cell membrane)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_74113" ], "products": [ "species_351626", "species_83910" ], "modifiers": [ [ "species_10522592", "catalyst" ] ], "additional_components": [ "Q8T5S1", "WBGene00003730", "G5EDU2", "WBGene00003732", "H2L039", "WBGene00003734", "O16452", "WBGene00003731", "P35449", "WBGene00003736" ] }, "reaction_10522518": { "compartment": "compartment_172574", "id": "reaction_10522518", "reactome": "R-CEL-425965", "name": "SLC9A9 exchanges Na+ for H+ across the late endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_425999", "species_83910" ], "products": [ "species_425977", "species_70106" ], "modifiers": [ [ "species_10522515", "catalyst" ] ], "additional_components": [ "WBGene00003733" ] }, "reaction_10522525": { "compartment": "compartment_171062", "id": "reaction_10522525", "reactome": "R-CEL-425983", "name": "SLC9A6,7 exchange Na+ for H+ across the early endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_425978", "species_83910" ], "products": [ "species_70106", "species_425971" ], "modifiers": [ [ "species_10522520", "catalyst" ] ], "additional_components": [ "WBGene00003733" ] }, "reaction_10522607": { "compartment": "compartment_20699", "id": "reaction_10522607", "reactome": "R-CEL-426015", "name": "Na+/H+ exchanger transport (at trans-golgi membrane)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_425969", "species_83910" ], "products": [ "species_70106", "species_425958" ], "modifiers": [ [ "species_10522604", "catalyst" ] ], "additional_components": [ "G5ED88", "WBGene00003733", "G5EBN7", "WBGene00003735" ] }, "reaction_10522643": { "compartment": "compartment_876", "id": "reaction_10522643", "reactome": "R-CEL-426130", "name": "SLC12A3 cotransports Cl-, Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_188972", "species_74113" ], "products": [ "species_83910", "species_352022" ], "modifiers": [ [ "species_10522640", "catalyst" ] ], "additional_components": [ "H8ESD5", "WBGene00012543", "P34261", "WBGene00015131" ] }, "reaction_10522634": { "compartment": "compartment_876", "id": "reaction_10522634", "reactome": "R-CEL-426086", "name": "SLC12A1,2 cotransports Na+, K+, 2Cl- from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74126", "species_188972", "species_74113" ], "products": [ "species_29804", "species_83910", "species_352022" ], "modifiers": [ [ "species_10522631", "catalyst" ] ], "additional_components": [ "P34261", "WBGene00015131", "H8ESD5", "WBGene00012543" ] }, "reaction_10522683": { "compartment": "compartment_876", "id": "reaction_10522683", "reactome": "R-CEL-426155", "name": "SLC12A4,5,6,7 cotransport K+, Cl- from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804", "species_352022" ], "products": [ "species_74126", "species_188972" ], "modifiers": [ [ "species_10522680", "catalyst" ] ], "additional_components": [ "S6FWN4", "WBGene00006504", "H2KZC3", "WBGene00019205", "Q09573", "WBGene00019289" ] }, "reaction_10523043": { "compartment": "compartment_201753", "id": "reaction_10523043", "reactome": "R-CEL-428052", "name": "SLC17A6,7,8 exchange cytosolic L-Glu for synaptic vesicle H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29404", "species_428548" ], "products": [ "species_70106", "species_428614" ], "modifiers": [ [ "species_10523040", "catalyst" ] ], "additional_components": [ "P34644", "WBGene00001135", "Q10046", "WBGene00011556", "G5EEK1", "WBGene00010755" ] }, "reaction_10523476": { "compartment": "compartment_876", "id": "reaction_10523476", "reactome": "R-CEL-429767", "name": "Passive I- efflux mediated by SMCT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_209785" ], "products": [ "species_209818" ], "modifiers": [ [ "species_10523470", "catalyst" ] ], "additional_components": [ "WBGene00018716" ] }, "reaction_10567367": { "compartment": "compartment_70101", "id": "reaction_10567367", "reactome": "R-CEL-8875623", "name": "SLC25A18,A22 cotransport Glu, H+ from cytosol to mitochondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29404", "species_70106" ], "products": [ "species_113529", "species_113552" ], "modifiers": [ [ "species_10567364", "catalyst" ] ], "additional_components": [ "Q20847", "WBGene00018901", "Q93540", "WBGene00008979" ] }, "reaction_10523415": { "compartment": "compartment_876", "id": "reaction_10523415", "reactome": "R-CEL-429591", "name": "SLC5A5 cotransports Na+ with I- from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_209818", "species_74113" ], "products": [ "species_209785", "species_83910" ], "modifiers": [ [ "species_10516451", "catalyst" ] ], "additional_components": [ "WBGene00018716" ] }, "reaction_10523020": { "compartment": "compartment_876", "id": "reaction_10523020", "reactome": "R-CEL-428015", "name": "SLC1A1,2,3,6,7 cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_428027", "species_29804", "species_74113" ], "products": [ "species_74126", "species_427997", "species_70106", "species_83910" ], "modifiers": [ [ "species_10516538", "catalyst" ] ], "additional_components": [ "species_427963", "species_6810061", "species_113552", "species_427963", "species_6810061", "species_113552", "Q21353", "WBGene00001621", "Q21751", "WBGene00001624", "Q22682", "WBGene00001622", "Q9UAY8", "WBGene00001625", "O18210", "WBGene00001623", "Q10901", "WBGene00001620" ] }, "reaction_10519220": { "compartment": "compartment_876", "id": "reaction_10519220", "reactome": "R-CEL-375405", "name": "SLC36A2 cotransports Gly, L-Pro with H+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_375409" ], "products": [ "species_70106", "species_375414" ], "modifiers": [ [ "species_10519217", "catalyst" ] ], "additional_components": [ "species_113538", "species_159549", "species_159549", "species_113538", "O62286", "WBGene00010421", "P34479", "WBGene00010307", "G4SQY7", "WBGene00020837", "Q18595", "WBGene00016628", "O45936", "WBGene00012804", "Q9XX44", "WBGene00012629" ] }, "reaction_10519225": { "compartment": "compartment_876", "id": "reaction_10519225", "reactome": "R-CEL-375417", "name": "SLC36A1-mediated uptake of glycine, proline, and alanine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_375400" ], "products": [ "species_70106", "species_375411" ], "modifiers": [ [ "species_10519222", "catalyst" ] ], "additional_components": [ "species_29432", "species_113538", "species_159549", "species_159549", "species_113538", "species_29432", "WBGene00012804" ] }, "reaction_10522933": { "compartment": "compartment_876", "id": "reaction_10522933", "reactome": "R-CEL-427605", "name": "SLC20A1,2 cotransport Pi, Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109277", "species_74113" ], "products": [ "species_29372", "species_83910" ], "modifiers": [ [ "species_10522930", "catalyst" ] ], "additional_components": [ "P91840", "WBGene00012285", "Q17454", "WBGene00015054", "O17404", "WBGene00017312", "Q17455", "WBGene00015055", "O45220", "WBGene00007141", "Q18697", "WBGene00016739" ] }, "reaction_10522941": { "compartment": "compartment_876", "id": "reaction_10522941", "reactome": "R-CEL-427645", "name": "SLC34A3 cotransports Pi, 2Na+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109277", "species_74113" ], "products": [ "species_29372", "species_83910" ], "modifiers": [ [ "species_10522938", "catalyst" ] ], "additional_components": [ "WBGene00022767" ] }, "reaction_10565621": { "compartment": "compartment_70101", "id": "reaction_10565621", "reactome": "R-CEL-8855062", "name": "SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2162252", "species_71284" ], "products": [ "species_2162265", "species_71285" ], "modifiers": [ [ "species_10565618", "catalyst" ] ], "additional_components": [ "WBGene00008364" ] }, "reaction_10566753": { "compartment": "compartment_876", "id": "reaction_10566753", "reactome": "R-CEL-8870354", "name": "SLC36A4 transports extracellular L-Pro to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352033" ], "products": [ "species_113538" ], "modifiers": [ [ "species_10566747", "catalyst" ] ], "additional_components": [ "O45936", "WBGene00012804", "O62286", "WBGene00010421", "P34479", "WBGene00010307", "Q18595", "WBGene00016628", "Q9XX44", "WBGene00012629", "G4SQY7", "WBGene00020837" ] }, "reaction_10519233": { "compartment": "compartment_876", "id": "reaction_10519233", "reactome": "R-CEL-375768", "name": "SLC7A2, isoform B (CAT-2B)-mediated uptake of cationic amino acids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_375765" ], "products": [ "species_375781" ], "modifiers": [ [ "species_10519230", "catalyst" ] ], "additional_components": [ "species_29444", "species_29468", "species_29468", "species_29444", "WBGene00013159" ] }, "reaction_10570181": { "compartment": "compartment_70101", "id": "reaction_10570181", "reactome": "R-CEL-8959781", "name": "SLC25A29 transports basic amino acids from cytosol to mitochondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8959777" ], "products": [ "species_8959775" ], "modifiers": [ [ "species_10570178", "catalyst" ] ], "additional_components": [ "CHEBI:28229", "species_29498", "species_29468", "species_29612", "species_29444", "CHEBI:27747", "species_29498", "species_29444", "species_29468", "species_29612", "CHEBI:28229", "CHEBI:27747", "WBGene00008320" ] }, "reaction_10519238": { "compartment": "compartment_876", "id": "reaction_10519238", "reactome": "R-CEL-375776", "name": "SLC7A1 (CAT-1)-mediated uptake of cationic amino acids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_375765" ], "products": [ "species_375781" ], "modifiers": [ [ "species_10519235", "catalyst" ] ], "additional_components": [ "species_29444", "species_29468", "species_29468", "species_29444", "WBGene00013159" ] }, "reaction_10519240": { "compartment": "compartment_876", "id": "reaction_10519240", "reactome": "R-CEL-375790", "name": "SLC7A2, isoform A (CAT-2A)-mediated uptake of cationic amino acids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_375765" ], "products": [ "species_375781" ], "modifiers": [ [ "species_10519230", "catalyst" ] ], "additional_components": [ "species_29444", "species_29468", "species_29468", "species_29444", "WBGene00013159" ] }, "reaction_10518156": { "compartment": "compartment_876", "id": "reaction_10518156", "reactome": "R-CEL-352379", "name": "SLC1A5-mediated exchange of alanine and glutamine across the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_83910", "species_352036", "species_29472", "species_74113" ], "products": [ "species_29432", "species_83910", "species_212615", "species_74113" ], "modifiers": [ [ "species_10518153", "catalyst" ] ], "additional_components": [ "Q21353", "WBGene00001621", "Q21751", "WBGene00001624", "Q22682", "WBGene00001622", "Q9UAY8", "WBGene00001625", "O18210", "WBGene00001623", "Q10901", "WBGene00001620" ] }, "reaction_10518133": { "compartment": "compartment_876", "id": "reaction_10518133", "reactome": "R-CEL-352347", "name": "SLC1A4-mediated exchange of extracellular serine for cytosolic alanine, threonine, or cysteine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352002", "species_83910", "species_352355", "species_74113" ], "products": [ "species_83910", "species_200736", "species_352359", "species_74113" ], "modifiers": [ [ "species_10518130", "catalyst" ] ], "additional_components": [ "species_200736", "species_351990", "species_29432", "species_111707", "species_29432", "species_351990", "species_111707", "species_200736", "Q9UAY8", "WBGene00001625", "O18210", "WBGene00001623", "Q10901", "WBGene00001620", "Q21353", "WBGene00001621", "Q21751", "WBGene00001624", "Q22682", "WBGene00001622" ] }, "reaction_10523018": { "compartment": "compartment_876", "id": "reaction_10523018", "reactome": "R-CEL-427998", "name": "Proton-coupled di- and tri-peptide cotransport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_428037" ], "products": [ "species_428026", "species_70106" ], "modifiers": [ [ "species_10523015", "catalyst" ] ], "additional_components": [ "CHEBI:90799", "CHEBI:47923", "CHEBI:47923", "CHEBI:90799", "WBGene00003876" ] }, "reaction_10523198": { "compartment": "compartment_201753", "id": "reaction_10523198", "reactome": "R-CEL-428625", "name": "Vesicular inhibitory amino acid transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428592", "species_428548" ], "products": [ "species_428632", "species_70106" ], "modifiers": [ [ "species_10523195", "catalyst" ] ], "additional_components": [ "species_159549", "species_352003", "species_352003", "species_159549", "WBGene00006783" ] }, "reaction_10565987": { "compartment": "compartment_876", "id": "reaction_10565987", "reactome": "R-CEL-8863494", "name": "ASICs bind STOML3, (STOM)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10565983", "species_10544954" ], "products": [ "species_10565985" ], "modifiers": [], "additional_components": [ "Q19958", "WBGene00006064", "Q20657", "WBGene00006065", "Q7YZV6", "WBGene00006067", "G3MU02", "WBGene00007775", "G5EGI5", "WBGene00001465", "species_70106", "G3MU02", "WBGene00007775", "G5EGI5", "WBGene00001465", "species_70106", "Q19958", "WBGene00006064", "Q20657", "WBGene00006065", "Q7YZV6", "WBGene00006067" ] }, "reaction_10544963": { "compartment": "compartment_70101", "id": "reaction_10544963", "reactome": "R-CEL-2671885", "name": "ASIC trimers:H+ transport extracellular Na+ to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74113" ], "products": [ "species_83910" ], "modifiers": [ [ "species_10544954", "catalyst" ], [ "species_2672379", "inhibitor" ], [ "species_2672383", "inhibitor" ], [ "species_10544961", "inhibitor" ] ], "additional_components": [ "G3MU02", "WBGene00007775", "G5EGI5", "WBGene00001465", "species_70106", "G3MU02", "WBGene00007775", "G5EGI5", "WBGene00001465" ] }, "reaction_10545603": { "compartment": "compartment_70101", "id": "reaction_10545603", "reactome": "R-CEL-2744242", "name": "TTYH2/3 transport cytosolic Cl- to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352022" ], "products": [ "species_188972" ], "modifiers": [ [ "species_10545598", "catalyst" ], [ "species_74016", "catalyst" ] ], "additional_components": [ "WBGene00009632" ] }, "reaction_10545477": { "compartment": "compartment_70101", "id": "reaction_10545477", "reactome": "R-CEL-2730692", "name": "CLCN4/5/6 exchange Cl- for H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_2731008" ], "products": [ "species_74722", "species_352022" ], "modifiers": [ [ "species_10545472", "catalyst" ] ], "additional_components": [ "WBGene00000532" ] }, "reaction_10545608": { "compartment": "compartment_70101", "id": "reaction_10545608", "reactome": "R-CEL-2744349", "name": "TTYH1 transports cytosolic Cl- to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352022" ], "products": [ "species_188972" ], "modifiers": [ [ "species_10545605", "catalyst" ] ], "additional_components": [ "WBGene00009632" ] }, "reaction_10573259": { "compartment": "compartment_70101", "id": "reaction_10573259", "reactome": "R-CEL-9701141", "name": "TRPV1 transports Ca2+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74112" ], "products": [ "species_74016" ], "modifiers": [ [ "species_10547087", "catalyst" ] ], "additional_components": [ "WBGene00003889" ] }, "reaction_10547102": { "compartment": "compartment_70101", "id": "reaction_10547102", "reactome": "R-CEL-3295579", "name": "TRPs transport extracellular Ca2+ to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74112" ], "products": [ "species_74016" ], "modifiers": [ [ "species_10547099", "catalyst" ] ], "additional_components": [ "G5ECM4", "WBGene00001795", "P34641", "WBGene00000425", "Q20766", "WBGene00001796", "Q93971", "WBGene00001651", "Q8T666", "WBGene00000846", "Q8I6Y9", "WBGene00006615", "Q19377", "WBGene00008731", "Q23141", "WBGene00020972", "G5EE29", "WBGene00021404", "P91448", "WBGene00004149", "G5EBV8", "WBGene00003889" ] }, "reaction_10547119": { "compartment": "compartment_70101", "id": "reaction_10547119", "reactome": "R-CEL-3295580", "name": "TRPM4,5 transport extracellular Na+ to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74113" ], "products": [ "species_83910" ], "modifiers": [ [ "species_10547116", "catalyst" ] ], "additional_components": [ "Q19377", "WBGene00008731", "G5EE29", "WBGene00021404", "P91448", "WBGene00004149", "Q23141", "WBGene00020972" ] }, "reaction_10572715": { "compartment": "compartment_876", "id": "reaction_10572715", "reactome": "R-CEL-9650165", "name": "ASIC trimers bind H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_10572713" ], "products": [ "species_10544954" ], "modifiers": [], "additional_components": [ "G3MU02", "WBGene00007775", "G5EGI5", "WBGene00001465", "G3MU02", "WBGene00007775", "G5EGI5", "WBGene00001465", "species_70106" ] }, "reaction_10545454": { "compartment": "compartment_70101", "id": "reaction_10545454", "reactome": "R-CEL-2682349", "name": "RAF1:SGK:TSC22D3:WPP ubiquitinates SCNN channels", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10545262", "species_113592", "species_10502375" ], "products": [ "species_29370", "species_947590", "species_10545415" ], "modifiers": [ [ "species_10545440", "catalyst" ], [ "species_10545446", "catalyst" ] ], "additional_components": [ "P24612", "WBGene00003168", "Q21974", "WBGene00006748", "P34886", "WBGene00003174", "Q22851", "WBGene00012137", "P91100", "WBGene00016066", "Q22970", "WBGene00017879", "P91102", "WBGene00016064", "Q8MPW0", "WBGene00011891", "P91103", "WBGene00016063", "Q93205", "WBGene00007518", "P91835", "WBGene00012116", "Q9U1T8", "WBGene00013487", "Q09274", "WBGene00006832", "Q9U1T9", "WBGene00013486", "Q10025", "WBGene00020897", "Q9XTS9", "WBGene00013480", "G5EFH3", "WBGene00010334", "Q18077", "WBGene00015957", "O01635", "WBGene00022815", "Q18651", "WBGene00016699", "O01664", "WBGene00020903", "Q19038", "WBGene00000952", "O45402", "WBGene00009073", "Q19777", "WBGene00009109", "P24585", "WBGene00000950", "Q20852", "WBGene00018906", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "P91103", "WBGene00016063", "P91835", "WBGene00012116", "Q09274", "WBGene00006832", "Q10025", "WBGene00020897", "Q18077", "WBGene00015957", "Q18651", "WBGene00016699", "Q19038", "WBGene00000952", "Q19777", "WBGene00009109", "Q20852", "WBGene00018906", "Q21974", "WBGene00006748", "Q22851", "WBGene00012137", "Q22970", "WBGene00017879", "Q8MPW0", "WBGene00011891", "Q93205", "WBGene00007518", "Q9U1T8", "WBGene00013487", "Q9U1T9", "WBGene00013486", "Q9XTS9", "WBGene00013480", "G5EFH3", "WBGene00010334", "O01635", "WBGene00022815", "O01664", "WBGene00020903", "O45402", "WBGene00009073", "P24585", "WBGene00000950", "P24612", "WBGene00003168", "P34886", "WBGene00003174", "P91100", "WBGene00016066", "P91102", "WBGene00016064", "A0A061ACQ8", "WBGene00022358", "Q9N2Z7", "WBGene00007009", "Q2PJ68", "WBGene00004789", "H2KYK3", "WBGene00016269", "Q9U290", "WBGene00016269", "Q07292", "WBGene00003030", "WBGene00006941" ] }, "reaction_10545550": { "compartment": "compartment_70101", "id": "reaction_10545550", "reactome": "R-CEL-2730959", "name": "CLCN7:OSTM1 exchanges Cl- for H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2730999", "species_70106" ], "products": [ "species_428040", "species_352022" ], "modifiers": [ [ "species_10545547", "catalyst" ] ], "additional_components": [ "G5EC75", "WBGene00000533", "Q09322", "WBGene00009627" ] }, "reaction_10545265": { "compartment": "compartment_984", "id": "reaction_10545265", "reactome": "R-CEL-2672334", "name": "SCNN channels transport extracellular Na+ to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74113" ], "products": [ "species_83910" ], "modifiers": [ [ "species_10545262", "catalyst" ], [ "species_2672379", "inhibitor" ] ], "additional_components": [ "P24612", "WBGene00003168", "Q21974", "WBGene00006748", "P34886", "WBGene00003174", "Q22851", "WBGene00012137", "P91100", "WBGene00016066", "Q22970", "WBGene00017879", "P91102", "WBGene00016064", "Q8MPW0", "WBGene00011891", "P91103", "WBGene00016063", "Q93205", "WBGene00007518", "P91835", "WBGene00012116", "Q9U1T8", "WBGene00013487", "Q09274", "WBGene00006832", "Q9U1T9", "WBGene00013486", "Q10025", "WBGene00020897", "Q9XTS9", "WBGene00013480", "G5EFH3", "WBGene00010334", "Q18077", "WBGene00015957", "O01635", "WBGene00022815", "Q18651", "WBGene00016699", "O01664", "WBGene00020903", "Q19038", "WBGene00000952", "O45402", "WBGene00009073", "Q19777", "WBGene00009109", "P24585", "WBGene00000950", "Q20852", "WBGene00018906" ] }, "reaction_10545970": { "compartment": "compartment_984", "id": "reaction_10545970", "reactome": "R-CEL-2872444", "name": "SLC9B1/C2 exchange Na+ for H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_74113" ], "products": [ "species_351626", "species_83910" ], "modifiers": [ [ "species_10545967", "catalyst" ] ], "additional_components": [ "G5EFS0", "WBGene00009618", "Q20273", "WBGene00009617", "Q9XU88", "WBGene00010214" ] }, "reaction_10545907": { "compartment": "compartment_70101", "id": "reaction_10545907", "reactome": "R-CEL-2744361", "name": "BESTs transport cytosolic Cl- to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352022" ], "products": [ "species_188972" ], "modifiers": [ [ "species_10545904", "catalyst" ], [ "species_74016", "catalyst" ] ], "additional_components": [ "O17206", "WBGene00015286", "Q18303", "WBGene00007808", "O17671", "WBGene00008186", "Q19978", "WBGene00009340", "O18303", "WBGene00014102", "Q21973", "WBGene00011258", "O18304", "WBGene00014103", "Q22566", "WBGene00020559", "O45363", "WBGene00008821", "Q23369", "WBGene00013921", "O45435", "WBGene00009323", "Q7YXH3", "WBGene00020046", "O62095", "WBGene00007988", "Q94175", "WBGene00016613", "P34319", "WBGene00007404", "Q965X4", "WBGene00021368", "P34577", "WBGene00011868", "Q9NA59", "WBGene00013520", "A5JYR2", "WBGene00014989", "P34672", "WBGene00022797", "J7RNL4", "WBGene00220250", "Q17528", "WBGene00007203", "O16779", "WBGene00206487", "Q17529", "WBGene00007204", "O17205", "WBGene00015288", "Q17851", "WBGene00015628" ] }, "reaction_10545975": { "compartment": "compartment_17927", "id": "reaction_10545975", "reactome": "R-CEL-2889070", "name": "SLC9B2 exchanges Na+, Li+ for H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113529", "species_2889081" ], "products": [ "species_2889062", "species_163953" ], "modifiers": [ [ "species_10545972", "catalyst" ] ], "additional_components": [ "species_83910", "species_425810", "species_425810", "species_83910", "WBGene00009617" ] }, "reaction_10545593": { "compartment": "compartment_70101", "id": "reaction_10545593", "reactome": "R-CEL-2744228", "name": "CLCN1/2/KA/KB transport cytosolic Cl- to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352022" ], "products": [ "species_188972" ], "modifiers": [ [ "species_10545590", "catalyst" ] ], "additional_components": [ "Q9BMK9", "WBGene00000530", "G5EG93", "WBGene00000529", "H2L0J1", "WBGene00000531", "Q22833", "WBGene00000528" ] }, "reaction_10545467": { "compartment": "compartment_70101", "id": "reaction_10545467", "reactome": "R-CEL-2684901", "name": "ANOs transport cytosolic Cl- to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352022" ], "products": [ "species_188972" ], "modifiers": [ [ "species_10545464", "catalyst" ], [ "species_74016", "catalyst" ] ], "additional_components": [ "WBGene00013326" ] }, "reaction_10545916": { "compartment": "compartment_70101", "id": "reaction_10545916", "reactome": "R-CEL-2752067", "name": "BESTs transport cytosolic HCO3- to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111627" ], "products": [ "species_425425" ], "modifiers": [ [ "species_10545904", "catalyst" ] ], "additional_components": [ "O17206", "WBGene00015286", "Q18303", "WBGene00007808", "O17671", "WBGene00008186", "Q19978", "WBGene00009340", "O18303", "WBGene00014102", "Q21973", "WBGene00011258", "O18304", "WBGene00014103", "Q22566", "WBGene00020559", "O45363", "WBGene00008821", "Q23369", "WBGene00013921", "O45435", "WBGene00009323", "Q7YXH3", "WBGene00020046", "O62095", "WBGene00007988", "Q94175", "WBGene00016613", "P34319", "WBGene00007404", "Q965X4", "WBGene00021368", "P34577", "WBGene00011868", "Q9NA59", "WBGene00013520", "A5JYR2", "WBGene00014989", "P34672", "WBGene00022797", "J7RNL4", "WBGene00220250", "Q17528", "WBGene00007203", "O16779", "WBGene00206487", "Q17529", "WBGene00007204", "O17205", "WBGene00015288", "Q17851", "WBGene00015628" ] }, "reaction_10529392": { "compartment": "compartment_20699", "id": "reaction_10529392", "reactome": "R-CEL-936883", "name": "ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_74016" ], "products": [ "species_29372", "species_29370", "species_167012" ], "modifiers": [ [ "species_10529389", "catalyst" ] ], "additional_components": [ "species_114632", "G5EDU1", "WBGene00004063" ] }, "reaction_10523009": { "compartment": "compartment_12045", "id": "reaction_10523009", "reactome": "R-CEL-427910", "name": "ATP2A1-3 transport Ca2+ from cytosol to ER lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_156540", "species_74016" ], "products": [ "species_70106", "species_111875" ], "modifiers": [ [ "species_10522985", "catalyst" ], [ "species_10523007", "catalyst" ] ], "additional_components": [ "WBGene00004736", "species_74016", "Q11083", "WBGene00020378", "P04630", "WBGene00000285", "G5EF37", "WBGene00003934", "A0A2C9C3L3", "WBGene00020378", "Q18136", "WBGene00006861", "Q09665", "WBGene00006583", "O02159", "WBGene00020378", "G5EDZ8", "WBGene00000288", "Q94288", "WBGene00000287", "Q09980", "WBGene00017394", "O16305", "WBGene00000552", "G5EEG0", "WBGene00000286", "O62305", "WBGene00006779" ] }, "reaction_10529571": { "compartment": "compartment_70101", "id": "reaction_10529571", "reactome": "R-CEL-947591", "name": "P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_947588", "species_113592" ], "products": [ "species_29372", "species_29370", "species_947594" ], "modifiers": [ [ "species_10529510", "catalyst" ] ], "additional_components": [ "species_33625", "species_8959490", "species_8959490", "species_33625", "O18182", "WBGene00012360", "Q7JPE3", "WBGene00020784", "Q9U280", "WBGene00013034", "U4PBV8", "WBGene00019166" ] }, "reaction_10556898": { "compartment": "compartment_70101", "id": "reaction_10556898", "reactome": "R-CEL-5692462", "name": "ATP13A1 transports Mn2+ from cytosol to ER lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_29418", "species_113592" ], "products": [ "species_29372", "species_29370", "species_1981162" ], "modifiers": [ [ "species_10556895", "catalyst" ] ], "additional_components": [ "WBGene00007514" ] }, "reaction_10556918": { "compartment": "compartment_70101", "id": "reaction_10556918", "reactome": "R-CEL-5692480", "name": "ATP13A2 transports cations from cytosol to lysosomal lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_5692450" ], "products": [ "species_29372", "species_29370", "species_5692484" ], "modifiers": [ [ "species_10556915", "catalyst" ] ], "additional_components": [ "Q9N323", "WBGene00022010", "Q21286", "WBGene00019493", "Q27533", "WBGene00012341" ] }, "reaction_10529455": { "compartment": "compartment_876", "id": "reaction_10529455", "reactome": "R-CEL-937311", "name": "ATP4A/12A:ATP4B exchanges K+ for H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74126", "species_29356", "species_70106", "species_113592" ], "products": [ "species_351626", "species_29804", "species_29372", "species_29370" ], "modifiers": [ [ "species_10529452", "catalyst" ] ], "additional_components": [ "O16331", "WBGene00015660", "O16436", "WBGene00015338", "P90735", "WBGene00001137", "G5EBE7", "WBGene00013672", "G5EFV6", "WBGene00007248", "Q9XUG9", "WBGene00008074", "Q9XUY5", "WBGene00010117", "Q93235", "WBGene00007646" ] }, "reaction_10565635": { "compartment": "compartment_876", "id": "reaction_10565635", "reactome": "R-CEL-8855130", "name": "VLDLR:PCSK9:Clathrin-coated vesicle translocates from the plasma membrane to lysosomal membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10565625" ], "products": [ "species_10565633" ], "modifiers": [], "additional_components": [ "P34574", "WBGene00011867", "P90961", "WBGene00020246", "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q04833", "WBGene00003071", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "Q9N4F3", "WBGene00000160", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q22601", "WBGene00000161", "Q04833", "WBGene00003071" ] }, "reaction_10567491": { "compartment": "compartment_161320", "id": "reaction_10567491", "reactome": "R-CEL-8876472", "name": "NPC2 binds CHOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10567487", "species_8848047" ], "products": [ "species_10567489" ], "modifiers": [], "additional_components": [ "WBGene00006452", "species_193384", "O17271", "WBGene00006452" ] }, "reaction_10511510": { "compartment": "compartment_74700", "id": "reaction_10511510", "reactome": "R-CEL-171087", "name": "LDLR [endosome membrane] => LDLR [plasma membrane]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10511502" ], "products": [ "species_10511508" ], "modifiers": [], "additional_components": [ "O01768", "WBGene00003072", "Q04833", "WBGene00003071", "O01768", "WBGene00003072", "Q04833", "WBGene00003071" ] }, "reaction_10567497": { "compartment": "compartment_161320", "id": "reaction_10567497", "reactome": "R-CEL-8876484", "name": "NPC2 transfers CHOL to NPC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10567493", "species_10567489" ], "products": [ "species_10567487", "species_10567495" ], "modifiers": [], "additional_components": [ "WBGene00003562", "species_193384", "O17271", "WBGene00006452", "WBGene00006452", "P34389", "WBGene00003562", "species_193384" ] }, "reaction_10567499": { "compartment": "compartment_12045", "id": "reaction_10567499", "reactome": "R-CEL-8876485", "name": "CHOL translocates from lysosome membrane to ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10567495" ], "products": [ "species_193384", "species_10567493" ], "modifiers": [], "additional_components": [ "P34389", "WBGene00003562", "species_193384", "WBGene00003562" ] }, "reaction_10558091": { "compartment": "compartment_1660541", "id": "reaction_10558091", "reactome": "R-CEL-6784729", "name": "PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10558057" ], "products": [ "species_10558089" ], "modifiers": [], "additional_components": [ "P34574", "WBGene00011867", "P90961", "WBGene00020246", "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "O01768", "WBGene00003072", "Q04833", "WBGene00003071", "O01768", "WBGene00003072", "Q04833", "WBGene00003071", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "Q9N4F3", "WBGene00000160", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q22601", "WBGene00000161" ] }, "reaction_10567546": { "compartment": "compartment_12045", "id": "reaction_10567546", "reactome": "R-CEL-8876696", "name": "SOAT1,2 transfer acyl group to CHOL forming CHEST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193384", "species_1500578" ], "products": [ "species_8876704", "species_76194" ], "modifiers": [ [ "species_10567541", "catalyst" ] ], "additional_components": [ "WBGene00007174" ] }, "reaction_10558093": { "compartment": "compartment_1660541", "id": "reaction_10558093", "reactome": "R-CEL-6784738", "name": "Degradation of PCSK9:LDLR:Clathrin-coated vesicle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10558089" ], "products": [ "species_10558087" ], "modifiers": [], "additional_components": [ "O01768", "WBGene00003072", "Q04833", "WBGene00003071", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "Q9N4F3", "WBGene00000160", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q22601", "WBGene00000161", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "Q9N4F3", "WBGene00000160", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q22601", "WBGene00000161" ] }, "reaction_10564126": { "compartment": "compartment_70101", "id": "reaction_10564126", "reactome": "R-CEL-6813720", "name": "NCEH1 hydrolyzes cholesterol esters", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_163579" ], "products": [ "species_8876730", "species_216762" ], "modifiers": [ [ "species_10564123", "catalyst" ] ], "additional_components": [ "Q19839", "WBGene00009186", "Q7JMM5", "WBGene00017515", "Q94187", "WBGene00017515", "Q9XWL5", "WBGene00012810" ] }, "reaction_10511233": { "compartment": "compartment_70101", "id": "reaction_10511233", "reactome": "R-CEL-170126", "name": "Phosphorylation of Cyclin B1 in the CRS domain", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10511226", "species_113592" ], "products": [ "species_29370", "species_10511126" ], "modifiers": [ [ "species_10511230", "catalyst" ] ], "additional_components": [ "Q10653", "WBGene00000865", "Q9BLB5", "WBGene00000867", "O45926", "WBGene00000866", "P34556", "WBGene00000405", "Q9BLB5", "WBGene00000867", "O45926", "WBGene00000866", "Q10653", "WBGene00000865", "P34556", "WBGene00000405" ] }, "reaction_10565795": { "compartment": "compartment_7660", "id": "reaction_10565795", "reactome": "R-CEL-8856945", "name": "PP2A methylation by LCMT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10533066" ], "products": [ "species_77502", "species_10565787" ], "modifiers": [ [ "species_10565792", "catalyst" ] ], "additional_components": [ "WBGene00007137" ] }, "reaction_10511235": { "compartment": "compartment_13231", "id": "reaction_10511235", "reactome": "R-CEL-170131", "name": "Translocation of CRS phosphorylated Cyclin B1:Cdc2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10511126" ], "products": [ "species_10511156" ], "modifiers": [], "additional_components": [ "Q9BLB5", "WBGene00000867", "O45926", "WBGene00000866", "Q10653", "WBGene00000865", "P34556", "WBGene00000405", "O45926", "WBGene00000866", "Q10653", "WBGene00000865", "Q9BLB5", "WBGene00000867", "P34556", "WBGene00000405" ] }, "reaction_10511269": { "compartment": "compartment_70101", "id": "reaction_10511269", "reactome": "R-CEL-170161", "name": "Dephosphorylation of cytoplasmic Cyclin B1/B2:phospho-Cdc2 (Thr 14, Tyr 15) complexes by CDC25B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10511262", "species_29356" ], "products": [ "species_29372", "species_10511266" ], "modifiers": [ [ "species_10511222", "catalyst" ] ], "additional_components": [ "Q10653", "WBGene00000865", "Q9BLB5", "WBGene00000867", "O45926", "WBGene00000866", "P34556", "WBGene00000405", "Q10653", "WBGene00000865", "P34556", "WBGene00000405", "Q9BLB5", "WBGene00000867", "O45926", "WBGene00000866", "WBGene00000389" ] }, "reaction_10511239": { "compartment": "compartment_13231", "id": "reaction_10511239", "reactome": "R-CEL-170149", "name": "Translocation of active Cdc25C to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509859" ], "products": [ "species_10511237" ], "modifiers": [], "additional_components": [ "WBGene00000389", "WBGene00000389" ] }, "reaction_10511175": { "compartment": "compartment_70101", "id": "reaction_10511175", "reactome": "R-CEL-170055", "name": "Myt-1 mediated phosphorylation of Cyclin B:Cdc2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10511168" ], "products": [ "species_29370", "species_10511170" ], "modifiers": [ [ "species_10511172", "catalyst" ] ], "additional_components": [ "Q10653", "WBGene00000865", "Q9BLB5", "WBGene00000867", "O45926", "WBGene00000866", "P34556", "WBGene00000405", "P34556", "WBGene00000405", "Q10653", "WBGene00000865", "Q9BLB5", "WBGene00000867", "O45926", "WBGene00000866", "WBGene00006940" ] }, "reaction_10511208": { "compartment": "compartment_70101", "id": "reaction_10511208", "reactome": "R-CEL-170084", "name": "Formation of Cyclin A:Cdc2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10511166", "species_10511204" ], "products": [ "species_10511206" ], "modifiers": [], "additional_components": [ "WBGene00000405", "P34556", "WBGene00000405" ] }, "reaction_10511177": { "compartment": "compartment_70101", "id": "reaction_10511177", "reactome": "R-CEL-170057", "name": "Formation of Cyclin B:Cdc2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10511166", "species_10511164" ], "products": [ "species_10511168" ], "modifiers": [], "additional_components": [ "WBGene00000405", "Q10653", "WBGene00000865", "Q9BLB5", "WBGene00000867", "O45926", "WBGene00000866", "Q10653", "WBGene00000865", "Q9BLB5", "WBGene00000867", "O45926", "WBGene00000866", "P34556", "WBGene00000405" ] }, "reaction_10565803": { "compartment": "compartment_7660", "id": "reaction_10565803", "reactome": "R-CEL-8856951", "name": "PP2A demethylation by PPME1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10565787" ], "products": [ "species_10533066", "species_8857797" ], "modifiers": [ [ "species_10565800", "catalyst" ] ], "additional_components": [ "WBGene00007188" ] }, "reaction_10511214": { "compartment": "compartment_7660", "id": "reaction_10511214", "reactome": "R-CEL-170087", "name": "CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10511210" ], "products": [ "species_113582", "species_10511212" ], "modifiers": [ [ "species_10506279", "catalyst" ] ], "additional_components": [ "P34556", "WBGene00000405", "P34556", "WBGene00000405", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408" ] }, "reaction_10511246": { "compartment": "compartment_7660", "id": "reaction_10511246", "reactome": "R-CEL-170153", "name": "Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10511144" ], "products": [ "species_113550", "species_10511241" ], "modifiers": [ [ "species_10511243", "catalyst" ] ], "additional_components": [ "O45926", "WBGene00000866", "Q10653", "WBGene00000865", "Q9BLB5", "WBGene00000867", "P34556", "WBGene00000405", "O45926", "WBGene00000866", "Q10653", "WBGene00000865", "Q9BLB5", "WBGene00000867", "P34556", "WBGene00000405", "Q21762", "WBGene00000389" ] }, "reaction_10511218": { "compartment": "compartment_13231", "id": "reaction_10511218", "reactome": "R-CEL-170088", "name": "Translocation of Cyclin A:phospho-Cdc2 (Thr 14) to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10511216" ], "products": [ "species_10511210" ], "modifiers": [], "additional_components": [ "P34556", "WBGene00000405", "P34556", "WBGene00000405" ] }, "reaction_10511252": { "compartment": "compartment_7660", "id": "reaction_10511252", "reactome": "R-CEL-170158", "name": "Dephosphorylation of nuclear Cyclin A:phospho-Cdc2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10511248" ], "products": [ "species_113550", "species_10511250" ], "modifiers": [ [ "species_10502759", "catalyst" ] ], "additional_components": [ "P34556", "WBGene00000405", "P34556", "WBGene00000405", "WBGene00000389" ] }, "reaction_10511188": { "compartment": "compartment_13231", "id": "reaction_10511188", "reactome": "R-CEL-170072", "name": "Translocation of Cyclin B1:phospho-Cdc2 to the cytoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10511144" ], "products": [ "species_10511104" ], "modifiers": [ [ "species_10511186", "catalyst" ] ], "additional_components": [ "O45926", "WBGene00000866", "Q10653", "WBGene00000865", "Q9BLB5", "WBGene00000867", "P34556", "WBGene00000405", "Q10653", "WBGene00000865", "Q9BLB5", "WBGene00000867", "O45926", "WBGene00000866", "P34556", "WBGene00000405", "WBGene00002078" ] }, "reaction_10511160": { "compartment": "compartment_13231", "id": "reaction_10511160", "reactome": "R-CEL-170044", "name": "Translocation of Cyclin B1:phospho-Cdc2 complexes to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10511128" ], "products": [ "species_10511158" ], "modifiers": [], "additional_components": [ "Q10653", "WBGene00000865", "Q9BLB5", "WBGene00000867", "O45926", "WBGene00000866", "P34556", "WBGene00000405", "O45926", "WBGene00000866", "Q10653", "WBGene00000865", "Q9BLB5", "WBGene00000867", "P34556", "WBGene00000405" ] }, "reaction_10511192": { "compartment": "compartment_7660", "id": "reaction_10511192", "reactome": "R-CEL-170076", "name": "CAK-mediated phosphorylation of Cyclin B1:Cdc2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10511140" ], "products": [ "species_113582", "species_10511181" ], "modifiers": [ [ "species_10506279", "catalyst" ] ], "additional_components": [ "O45926", "WBGene00000866", "Q10653", "WBGene00000865", "Q9BLB5", "WBGene00000867", "P34556", "WBGene00000405", "O45926", "WBGene00000866", "Q10653", "WBGene00000865", "Q9BLB5", "WBGene00000867", "P34556", "WBGene00000405", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408" ] }, "reaction_10511224": { "compartment": "compartment_13231", "id": "reaction_10511224", "reactome": "R-CEL-170120", "name": "Translocation of Cdc25B to the cytoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10511220" ], "products": [ "species_10511222" ], "modifiers": [], "additional_components": [ "WBGene00000389", "WBGene00000389" ] }, "reaction_10511258": { "compartment": "compartment_13231", "id": "reaction_10511258", "reactome": "R-CEL-170159", "name": "Translocation of Cdc25 to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10511256" ], "products": [ "species_10511243" ], "modifiers": [], "additional_components": [ "Q21762", "WBGene00000389", "Q21762", "WBGene00000389" ] }, "reaction_10546257": { "compartment": "compartment_70101", "id": "reaction_10546257", "reactome": "R-CEL-3002798", "name": "Cytosolic PLK1 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509861" ], "products": [ "species_10509851" ], "modifiers": [], "additional_components": [ "WBGene00004043", "WBGene00004043" ] }, "reaction_10546277": { "compartment": "compartment_7660", "id": "reaction_10546277", "reactome": "R-CEL-3002811", "name": "Myosin phosphatase dephosphorylates PLK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10509851" ], "products": [ "species_113550", "species_10546259" ], "modifiers": [ [ "species_10546274", "catalyst" ] ], "additional_components": [ "WBGene00004043", "WBGene00004043", "Q27497", "WBGene00001747", "G5ECD7", "WBGene00003196" ] }, "reaction_10548983": { "compartment": "compartment_70101", "id": "reaction_10548983", "reactome": "R-CEL-4086410", "name": "CDK1 phosphorylates BORA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10548981" ], "products": [ "species_29370", "species_10546195" ], "modifiers": [ [ "species_10511266", "catalyst" ] ], "additional_components": [ "WBGene00010198", "WBGene00010198", "Q10653", "WBGene00000865", "P34556", "WBGene00000405", "Q9BLB5", "WBGene00000867", "O45926", "WBGene00000866" ] }, "reaction_10546204": { "compartment": "compartment_70101", "id": "reaction_10546204", "reactome": "R-CEL-3000327", "name": "PLK1 phosphorylates BORA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10546197" ], "products": [ "species_29370", "species_10546201", "species_10509861" ], "modifiers": [ [ "species_10546197", "catalyst" ] ], "additional_components": [ "H2FLK2", "WBGene00010198", "Q9N2L7", "WBGene00004043", "WBGene00010198", "WBGene00004043", "H2FLK2", "WBGene00010198", "Q9N2L7", "WBGene00004043" ] }, "reaction_10565466": { "compartment": "compartment_70101", "id": "reaction_10565466", "reactome": "R-CEL-8854041", "name": "SCF-FBXL7 ubiquitinates AURKA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10565421", "species_10502375" ], "products": [ "species_10565463" ], "modifiers": [ [ "species_10565421", "catalyst" ] ], "additional_components": [ "G5ECU1", "WBGene00004807", "Q17389", "WBGene00000836", "Q23457", "WBGene00004320", "O01427", "WBGene00000099", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "O01427", "WBGene00000099", "G5ECU1", "WBGene00004807", "Q17389", "WBGene00000836", "Q23457", "WBGene00004320", "G5ECU1", "WBGene00004807", "Q17389", "WBGene00000836", "Q23457", "WBGene00004320", "O01427", "WBGene00000099" ] }, "reaction_10565468": { "compartment": "compartment_70101", "id": "reaction_10565468", "reactome": "R-CEL-8854044", "name": "Proteasome degrades AURKA ubiquitinated by SCF-FBXL7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10565463" ], "products": [ "species_10502375", "species_10565414" ], "modifiers": [ [ "species_10502572", "catalyst" ] ], "additional_components": [ "O01427", "WBGene00000099", "G5ECU1", "WBGene00004807", "Q17389", "WBGene00000836", "Q23457", "WBGene00004320", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "G5ECU1", "WBGene00004807", "Q17389", "WBGene00000836", "Q23457", "WBGene00004320", "P91477", "WBGene00003950", "Q95PZ7", "WBGene00013435", "Q18115", "WBGene00004459", "O62102", "WBGene00003948", "O17071", "WBGene00004504", "Q10920", "WBGene00016623", "P34286", "WBGene00003952", "Q9XTT9", "WBGene00004506", "Q23449", "WBGene00004468", "Q95005", "WBGene00003925", "P46502", "WBGene00004503", "O61792", "WBGene00004464", "O17586", "WBGene00003922", "O76371", "WBGene00004505", "Q20585", "WBGene00004463", "Q95008", "WBGene00003926", "Q18787", "WBGene00004501", "Q20058", "WBGene00009445", "Q9N599", "WBGene00003924", "O16368", "WBGene00004502", "O61742", "WBGene00004466", "Q09583", "WBGene00003928", "Q966I8", "WBGene00003947", "Q04908", "WBGene00004460", "Q9XUV0", "WBGene00003951", "Q27488", "WBGene00003923", "Q9GZH5", "WBGene00004458", "O44156", "WBGene00003927", "Q22253", "WBGene00004465", "O76577", "WBGene00004467", "P90868", "WBGene00003953", "Q19324", "WBGene00004461", "Q17971", "WBGene00007588", "Q23237", "WBGene00003949", "Q20938", "WBGene00004462" ] }, "reaction_10565423": { "compartment": "compartment_70101", "id": "reaction_10565423", "reactome": "R-CEL-8853496", "name": "SCF:FBXL7 binds AURKA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10565419", "species_10565414" ], "products": [ "species_10565421" ], "modifiers": [], "additional_components": [ "WBGene00000099", "G5ECU1", "WBGene00004807", "Q17389", "WBGene00000836", "Q23457", "WBGene00004320", "G5ECU1", "WBGene00004807", "Q17389", "WBGene00000836", "Q23457", "WBGene00004320", "O01427", "WBGene00000099" ] }, "reaction_10565570": { "compartment": "compartment_20699", "id": "reaction_10565570", "reactome": "R-CEL-8854303", "name": "TBC1D11 binds RAB6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10565566", "species_10564844" ], "products": [ "species_10565568" ], "modifiers": [], "additional_components": [ "WBGene00018075", "Q22782", "WBGene00004270", "P34213", "WBGene00004269", "species_29438", "Q22782", "WBGene00004270", "P34213", "WBGene00004269", "species_29438", "H2KZZ6", "WBGene00018075" ] }, "reaction_10565591": { "compartment": "compartment_5683628", "id": "reaction_10565591", "reactome": "R-CEL-8854612", "name": "TBC1D25 accelerates GTP hydrolysis by RAB33B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10565586" ], "products": [ "species_29372", "species_10565588" ], "modifiers": [ [ "species_10565586", "catalyst" ] ], "additional_components": [ "species_29438", "Q20365", "WBGene00004283", "species_29420", "Q20365", "WBGene00004283", "species_29438", "Q20365", "WBGene00004283" ] }, "reaction_10565561": { "compartment": "compartment_262783", "id": "reaction_10565561", "reactome": "R-CEL-8854293", "name": "TBC1D10A (EPI64) binds ARF6:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10565550", "species_10565557" ], "products": [ "species_10565559" ], "modifiers": [], "additional_components": [ "WBGene00019915", "Q9U2S4", "WBGene00000184", "species_29438", "Q9U2S4", "WBGene00000184", "species_29438", "O44873", "WBGene00019915" ] }, "reaction_10565576": { "compartment": "compartment_17938", "id": "reaction_10565576", "reactome": "R-CEL-8854329", "name": "TBC1D15 accelerates GTP hydrolysis by RAB7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10565537" ], "products": [ "species_29372", "species_10565574" ], "modifiers": [ [ "species_10565537", "catalyst" ] ], "additional_components": [ "species_29438", "Q23146", "WBGene00004271", "species_29420", "Q23146", "WBGene00004271", "species_29438", "Q23146", "WBGene00004271" ] }, "reaction_10565547": { "compartment": "compartment_17938", "id": "reaction_10565547", "reactome": "R-CEL-8854255", "name": "TBC1D2A accelerates GTP hydrolysis by RAB7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10565537" ], "products": [ "species_29372", "species_10565539" ], "modifiers": [ [ "species_10565537", "catalyst" ], [ "species_10565545", "catalyst" ] ], "additional_components": [ "species_29438", "Q23146", "WBGene00004271", "species_29420", "Q23146", "WBGene00004271", "species_29438", "Q23146", "WBGene00004271", "WBGene00007849" ] }, "reaction_10565498": { "compartment": "compartment_24339", "id": "reaction_10565498", "reactome": "R-CEL-8854173", "name": "TBC RabGAPs accelerate GTP hydrolysis by RAB35", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10565475" ], "products": [ "species_29372", "species_10565477" ], "modifiers": [ [ "species_10565475", "catalyst" ], [ "species_10565496", "catalyst" ] ], "additional_components": [ "Q9U2C3", "WBGene00004284", "species_29438", "Q9U2C3", "WBGene00004284", "species_29420", "Q9U2C3", "WBGene00004284", "species_29438", "Q20436", "WBGene00009726", "H2KZ54", "WBGene00016292", "O44873", "WBGene00019915" ] }, "reaction_10565533": { "compartment": "compartment_171062", "id": "reaction_10565533", "reactome": "R-CEL-8854222", "name": "TBC1D3 associates with RAB5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10565501", "species_10565529" ], "products": [ "species_10565531" ], "modifiers": [], "additional_components": [ "WBGene00012894", "P91857", "WBGene00004268", "species_29438", "Q23165", "WBGene00000166", "A0A486WY48", "WBGene00012644", "P91857", "WBGene00004268", "species_29438", "Q23165", "WBGene00000166", "A0A486WY48", "WBGene00012644", "Q9U2D8", "WBGene00012894" ] }, "reaction_10565613": { "compartment": "compartment_262783", "id": "reaction_10565613", "reactome": "R-CEL-8854759", "name": "TBC1D14 binds RAB11 and ULK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10565609", "species_10565604", "species_10565602" ], "products": [ "species_10565611" ], "modifiers": [], "additional_components": [ "WBGene00044061", "WBGene00006786", "WBGene00004274", "O01803", "WBGene00004274", "Q23023", "WBGene00006786", "Q21928", "WBGene00044061" ] }, "reaction_10554302": { "compartment": "compartment_7660", "id": "reaction_10554302", "reactome": "R-CEL-5653838", "name": "POLD,POLE binds deISGylated PCNA after TLS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10554298", "species_10508801" ], "products": [ "species_10554300" ], "modifiers": [], "additional_components": [ "Q95Y97", "WBGene00019767", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "O02115", "WBGene00003955", "P90829", "WBGene00008645", "Q19366", "WBGene00008722", "Q21730", "WBGene00011016", "P90829", "WBGene00008645", "Q19366", "WBGene00008722", "Q21730", "WBGene00011016", "Q95Y97", "WBGene00019767", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "O02115", "WBGene00003955" ] }, "reaction_10551331": { "compartment": "compartment_263163", "id": "reaction_10551331", "reactome": "R-CEL-5333658", "name": "CLAT:AP1:CLVS bind PI(3,5)P2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10551327", "species_5334668" ], "products": [ "species_10551329" ], "modifiers": [], "additional_components": [ "P35602", "WBGene00006829", "O01755", "WBGene00000150", "O16369", "WBGene00000159", "Q9N4F3", "WBGene00000160", "Q8WQB3", "WBGene00000158", "P34574", "WBGene00011867", "species_5334668", "P35602", "WBGene00006829", "O01755", "WBGene00000150", "O16369", "WBGene00000159", "Q9N4F3", "WBGene00000160", "Q8WQB3", "WBGene00000158", "P34574", "WBGene00011867" ] }, "reaction_10524037": { "compartment": "compartment_70101", "id": "reaction_10524037", "reactome": "R-CEL-432706", "name": "trans-Golgi Network Lysosome Vesicle Destined Membrane Coat Assembly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10524031", "species_10522248", "species_10512231", "species_10522246" ], "products": [ "species_10517983", "species_29372", "species_10524035" ], "modifiers": [], "additional_components": [ "Q8WQB3", "WBGene00000158", "O01755", "WBGene00000150", "P35602", "WBGene00006829", "O16369", "WBGene00000159", "Q9N4F3", "WBGene00000160", "P51485", "WBGene00000195", "G5EFK4", "WBGene00000183", "species_29438", "WBGene00001130", "WBGene00006791", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "species_29420", "G5EFK4", "WBGene00000183", "Q8WQB3", "WBGene00000158", "O01755", "WBGene00000150", "P35602", "WBGene00006829", "O16369", "WBGene00000159", "Q9N4F3", "WBGene00000160", "P51485", "WBGene00000195", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "B1V8A0", "WBGene00006791", "P39055", "WBGene00001130" ] }, "reaction_10524040": { "compartment": "compartment_70101", "id": "reaction_10524040", "reactome": "R-CEL-432707", "name": "trans-Golgi Network Lysosomal Vesicle Scission", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10524035" ], "products": [ "species_29372", "species_29420", "species_10522248", "species_10512231", "species_10524001" ], "modifiers": [ [ "species_10524035", "catalyst" ] ], "additional_components": [ "Q8WQB3", "WBGene00000158", "O01755", "WBGene00000150", "P35602", "WBGene00006829", "O16369", "WBGene00000159", "Q9N4F3", "WBGene00000160", "P51485", "WBGene00000195", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "B1V8A0", "WBGene00006791", "P39055", "WBGene00001130", "WBGene00001130", "WBGene00006791", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "O01755", "WBGene00000150", "P35602", "WBGene00006829", "O16369", "WBGene00000159", "Q8WQB3", "WBGene00000158", "Q9N4F3", "WBGene00000160", "P51485", "WBGene00000195", "Q8WQB3", "WBGene00000158", "O01755", "WBGene00000150", "P35602", "WBGene00006829", "O16369", "WBGene00000159", "Q9N4F3", "WBGene00000160", "P51485", "WBGene00000195", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "B1V8A0", "WBGene00006791", "P39055", "WBGene00001130" ] }, "reaction_10554828": { "compartment": "compartment_20699", "id": "reaction_10554828", "reactome": "R-CEL-5671702", "name": "AP1G2 binds HGS and CHMP2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10554824", "species_10529030", "species_10512214" ], "products": [ "species_10554826" ], "modifiers": [], "additional_components": [ "WBGene00000158", "WBGene00012903", "WBGene00004101", "Q9U2F6", "WBGene00012903", "Q17796", "WBGene00004101", "Q8WQB3", "WBGene00000158" ] }, "reaction_10518097": { "compartment": "compartment_13231", "id": "reaction_10518097", "reactome": "R-CEL-351947", "name": "Nuclear translocation of catalytic domain of Mst3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10518081" ], "products": [ "species_10518095" ], "modifiers": [], "additional_components": [ "WBGene00001526", "WBGene00001526" ] }, "reaction_10518085": { "compartment": "compartment_70101", "id": "reaction_10518085", "reactome": "R-CEL-351901", "name": "Caspase-mediated cleavage of MST3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10518079" ], "products": [ "species_10518083", "species_10518081" ], "modifiers": [ [ "species_10509422", "catalyst" ] ], "additional_components": [ "WBGene00001526", "WBGene00001526", "WBGene00001526", "P42573", "WBGene00000417" ] }, "reaction_10515329": { "compartment": "compartment_70101", "id": "reaction_10515329", "reactome": "R-CEL-202917", "name": "Caspase-mediated cleavage of Desmoglein 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10515323" ], "products": [ "species_10515327", "species_10515325" ], "modifiers": [ [ "species_10509422", "catalyst" ] ], "additional_components": [ "WBGene00000396", "WBGene00000396", "WBGene00000396", "P42573", "WBGene00000417" ] }, "reaction_10514849": { "compartment": "compartment_876", "id": "reaction_10514849", "reactome": "R-CEL-201595", "name": "Caspase-mediated cleavage of plakophilin-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10514844" ], "products": [ "species_10514846" ], "modifiers": [ [ "species_10509422", "catalyst" ] ], "additional_components": [ "WBGene00002175", "WBGene00002175", "P42573", "WBGene00000417" ] }, "reaction_10518066": { "compartment": "compartment_876", "id": "reaction_10518066", "reactome": "R-CEL-351877", "name": "Caspase-mediated cleavage of Desmoglein 2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10518062" ], "products": [ "species_10518064" ], "modifiers": [ [ "species_10509422", "catalyst" ] ], "additional_components": [ "WBGene00000396", "WBGene00000396", "P42573", "WBGene00000417" ] }, "reaction_10518052": { "compartment": "compartment_876", "id": "reaction_10518052", "reactome": "R-CEL-351871", "name": "Caspase-mediated cleavage of Z0-2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10518048" ], "products": [ "species_10518050" ], "modifiers": [ [ "species_10509422", "catalyst" ] ], "additional_components": [ "WBGene00013683", "WBGene00013683", "P42573", "WBGene00000417" ] }, "reaction_10514901": { "compartment": "compartment_70101", "id": "reaction_10514901", "reactome": "R-CEL-201631", "name": "Caspase-mediated cleavage of Desmoglein 3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10514895" ], "products": [ "species_10514899", "species_10514897" ], "modifiers": [ [ "species_10509422", "catalyst" ] ], "additional_components": [ "WBGene00000396", "WBGene00000396", "WBGene00000396", "P42573", "WBGene00000417" ] }, "reaction_10515367": { "compartment": "compartment_70101", "id": "reaction_10515367", "reactome": "R-CEL-202969", "name": "Caspase mediated cleavage of beta-catenin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10515361" ], "products": [ "species_10515365", "species_10515363" ], "modifiers": [ [ "species_10509422", "catalyst" ] ], "additional_components": [ "WBGene00001979", "WBGene00001979", "P42573", "WBGene00000417" ] }, "reaction_10514919": { "compartment": "compartment_70101", "id": "reaction_10514919", "reactome": "R-CEL-201636", "name": "Caspase-mediated cleavage of Desmoplakin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10514915" ], "products": [ "species_10514917" ], "modifiers": [ [ "species_10509422", "catalyst" ] ], "additional_components": [ "WBGene00006876", "WBGene00006876", "P42573", "WBGene00000417" ] }, "reaction_10518089": { "compartment": "compartment_876", "id": "reaction_10518089", "reactome": "R-CEL-351913", "name": "Caspase-mediated cleavage of TJP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10518087" ], "products": [ "species_10518050" ], "modifiers": [ [ "species_10509422", "catalyst" ] ], "additional_components": [ "WBGene00013683", "WBGene00013683", "P42573", "WBGene00000417" ] }, "reaction_10518060": { "compartment": "compartment_70101", "id": "reaction_10518060", "reactome": "R-CEL-351876", "name": "Caspase-mediated cleavage of occludin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10518054" ], "products": [ "species_10518058", "species_10518056" ], "modifiers": [ [ "species_10509422", "catalyst" ] ], "additional_components": [ "WBGene00021281", "WBGene00021281", "WBGene00021281", "P42573", "WBGene00000417" ] }, "reaction_10514936": { "compartment": "compartment_70101", "id": "reaction_10514936", "reactome": "R-CEL-201640", "name": "Caspase-mediated cleavage of farnesyltransferase/geranyl- geranyltransferase subunit alpha ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10514930" ], "products": [ "species_10514934", "species_10514932" ], "modifiers": [ [ "species_10509422", "catalyst" ] ], "additional_components": [ "WBGene00019823", "WBGene00019823", "WBGene00019823", "P42573", "WBGene00000417" ] }, "reaction_10517976": { "compartment": "compartment_70101", "id": "reaction_10517976", "reactome": "R-CEL-350651", "name": "Caspase-mediated cleavage of MASK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10517970" ], "products": [ "species_10517974", "species_10517972" ], "modifiers": [ [ "species_10509422", "catalyst" ] ], "additional_components": [ "WBGene00001526", "WBGene00001526", "WBGene00001526", "P42573", "WBGene00000417" ] }, "reaction_10515337": { "compartment": "compartment_70101", "id": "reaction_10515337", "reactome": "R-CEL-202947", "name": "Caspase mediated cleavage of APC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10515331" ], "products": [ "species_10515335", "species_10515333" ], "modifiers": [ [ "species_10509422", "catalyst" ] ], "additional_components": [ "WBGene00000156", "WBGene00000156", "WBGene00000156", "P42573", "WBGene00000417" ] }, "reaction_10517161": { "compartment": "compartment_70101", "id": "reaction_10517161", "reactome": "R-CEL-212552", "name": "Caspase 3-mediated cleavage of PKC delta", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509049" ], "products": [ "species_10517159", "species_10517157" ], "modifiers": [ [ "species_10509422", "catalyst" ] ], "additional_components": [ "WBGene00006599", "WBGene00006599", "WBGene00006599", "P42573", "WBGene00000417" ] }, "reaction_10514857": { "compartment": "compartment_70101", "id": "reaction_10514857", "reactome": "R-CEL-201603", "name": "Caspase-mediated cleavage of PKC theta", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10514851" ], "products": [ "species_10514855", "species_10514853" ], "modifiers": [ [ "species_10509422", "catalyst" ] ], "additional_components": [ "WBGene00006599", "WBGene00006599", "WBGene00006599", "P42573", "WBGene00000417" ] }, "reaction_10514890": { "compartment": "compartment_70101", "id": "reaction_10514890", "reactome": "R-CEL-201630", "name": "Caspase-mediated cleavage of Acinus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10514884" ], "products": [ "species_10514888", "species_10514886" ], "modifiers": [ [ "species_10509422", "catalyst" ] ], "additional_components": [ "WBGene00016601", "WBGene00016601", "WBGene00016601", "P42573", "WBGene00000417" ] }, "reaction_10514879": { "compartment": "compartment_70101", "id": "reaction_10514879", "reactome": "R-CEL-201611", "name": "Caspase-mediated cleavage of Rock-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10514873" ], "products": [ "species_10514877", "species_10514875" ], "modifiers": [ [ "species_10509422", "catalyst" ] ], "additional_components": [ "WBGene00002694", "WBGene00002694", "WBGene00002694", "P42573", "WBGene00000417" ] }, "reaction_10518106": { "compartment": "compartment_70101", "id": "reaction_10518106", "reactome": "R-CEL-351948", "name": "Mitochondrial recruitment of Drp1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10518102" ], "products": [ "species_10518104" ], "modifiers": [ [ "species_10518073", "catalyst" ] ], "additional_components": [ "WBGene00001093", "WBGene00001093", "WBGene00021883" ] }, "reaction_10512852": { "compartment": "compartment_876", "id": "reaction_10512852", "reactome": "R-CEL-189242", "name": "SLC2A2 tetramer transports Fru, Gal, Glc from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189246" ], "products": [ "species_189219" ], "modifiers": [ [ "species_10512849", "catalyst" ] ], "additional_components": [ "species_70113", "species_188995", "species_29532", "species_188995", "species_70113", "species_29532", "Q23626", "WBGene00022014", "Q95QY6", "WBGene00022014", "Q9GPA2", "WBGene00022014", "Q9N309", "WBGene00022014", "Q9U2K5", "WBGene00022014", "Q9XU83", "WBGene00022014", "Q9XVL3", "WBGene00022014", "G5EC93", "WBGene00022014", "O16547", "WBGene00022014", "O44616", "WBGene00022014", "O44827", "WBGene00019207", "O45920", "WBGene00022014", "Q11114", "WBGene00022014", "Q19376", "WBGene00022014", "Q20734", "WBGene00022014", "Q23535", "WBGene00006865" ] }, "reaction_10512813": { "compartment": "compartment_876", "id": "reaction_10512813", "reactome": "R-CEL-189222", "name": "SLC2A5 transports fructose from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189049" ], "products": [ "species_29532" ], "modifiers": [ [ "species_10512810", "catalyst" ] ], "additional_components": [ "Q20734", "WBGene00022014", "O16547", "WBGene00022014", "Q9XU83", "WBGene00022014", "Q23535", "WBGene00006865", "O44616", "WBGene00022014", "Q9XVL3", "WBGene00022014", "Q23626", "WBGene00022014", "O44827", "WBGene00019207", "Q95QY6", "WBGene00022014", "O45920", "WBGene00022014", "Q9GPA2", "WBGene00022014", "Q11114", "WBGene00022014", "Q9N309", "WBGene00022014", "Q19376", "WBGene00022014", "G5EC93", "WBGene00022014", "Q9U2K5", "WBGene00022014" ] }, "reaction_10554240": { "compartment": "compartment_7660", "id": "reaction_10554240", "reactome": "R-CEL-5652009", "name": "RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502318", "species_10554233" ], "products": [ "species_10554237", "species_10554231", "species_10508801" ], "modifiers": [ [ "species_10554233", "catalyst" ] ], "additional_components": [ "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "Q95Y97", "WBGene00019767", "P90829", "WBGene00008645", "Q19366", "WBGene00008722", "Q21730", "WBGene00011016", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "O02115", "WBGene00003955", "Q21554", "WBGene00010890", "Q23457", "WBGene00004320", "Q22059", "WBGene00011318", "Q17392", "WBGene00000839", "Q95Y97", "WBGene00019767", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "O02115", "WBGene00003955", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "Q21554", "WBGene00010890", "Q23457", "WBGene00004320", "Q22059", "WBGene00011318", "Q17392", "WBGene00000839", "P90829", "WBGene00008645", "Q19366", "WBGene00008722", "Q21730", "WBGene00011016", "Q95Y97", "WBGene00019767", "P90829", "WBGene00008645", "Q19366", "WBGene00008722", "Q21730", "WBGene00011016", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "O02115", "WBGene00003955", "Q21554", "WBGene00010890", "Q23457", "WBGene00004320", "Q22059", "WBGene00011318", "Q17392", "WBGene00000839" ] }, "reaction_10554235": { "compartment": "compartment_7660", "id": "reaction_10554235", "reactome": "R-CEL-5652005", "name": "RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10554231", "species_10554212" ], "products": [ "species_10554233" ], "modifiers": [], "additional_components": [ "Q21554", "WBGene00010890", "Q23457", "WBGene00004320", "Q22059", "WBGene00011318", "Q17392", "WBGene00000839", "Q95Y97", "WBGene00019767", "P90829", "WBGene00008645", "Q19366", "WBGene00008722", "Q21730", "WBGene00011016", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "O02115", "WBGene00003955", "Q95Y97", "WBGene00019767", "P90829", "WBGene00008645", "Q19366", "WBGene00008722", "Q21730", "WBGene00011016", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "O02115", "WBGene00003955", "Q21554", "WBGene00010890", "Q23457", "WBGene00004320", "Q22059", "WBGene00011318", "Q17392", "WBGene00000839" ] }, "reaction_10554419": { "compartment": "compartment_7660", "id": "reaction_10554419", "reactome": "R-CEL-5654989", "name": "SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10554410" ], "products": [ "species_113582", "species_10508757", "species_10554416" ], "modifiers": [ [ "species_10554410", "catalyst" ] ], "additional_components": [ "Q22557", "WBGene00011834", "Q95Y97", "WBGene00019767", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "O02115", "WBGene00003955", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "G5EFY1", "WBGene00018721", "Q95QZ9", "WBGene00019121", "Q19584", "WBGene00006733", "P54812", "WBGene00008053", "WBGene00018721", "Q95Y97", "WBGene00019767", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "O02115", "WBGene00003955", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "Q22557", "WBGene00011834", "Q95QZ9", "WBGene00019121", "Q19584", "WBGene00006733", "P54812", "WBGene00008053", "Q22557", "WBGene00011834", "Q95Y97", "WBGene00019767", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "O02115", "WBGene00003955", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "G5EFY1", "WBGene00018721", "Q95QZ9", "WBGene00019121", "Q19584", "WBGene00006733", "P54812", "WBGene00008053" ] }, "reaction_10508774": { "compartment": "compartment_7660", "id": "reaction_10508774", "reactome": "R-CEL-110317", "name": "Insertion of correct bases opposite the lesion by POLH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508763", "species_29604" ], "products": [ "species_113541", "species_10508771" ], "modifiers": [ [ "species_10508763", "catalyst" ] ], "additional_components": [ "G5EFY1", "WBGene00018721", "Q95Y97", "WBGene00019767", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "O02115", "WBGene00003955", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "Q95Y97", "WBGene00019767", "O02115", "WBGene00003955", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "G5EFY1", "WBGene00018721", "G5EFY1", "WBGene00018721", "Q95Y97", "WBGene00019767", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "O02115", "WBGene00003955", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725" ] }, "reaction_10508765": { "compartment": "compartment_7660", "id": "reaction_10508765", "reactome": "R-CEL-110316", "name": "POLH binds monoUb:K164-PCNA at damaged TT-CPD-DNA template", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508761", "species_10508757" ], "products": [ "species_10508763" ], "modifiers": [], "additional_components": [ "Q95Y97", "WBGene00019767", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "O02115", "WBGene00003955", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "WBGene00018721", "G5EFY1", "WBGene00018721", "Q95Y97", "WBGene00019767", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "O02115", "WBGene00003955", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725" ] }, "reaction_10508781": { "compartment": "compartment_7660", "id": "reaction_10508781", "reactome": "R-CEL-110319", "name": "Elongation by POLH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30555", "species_10508771" ], "products": [ "species_10508778", "species_113541" ], "modifiers": [ [ "species_10508771", "catalyst" ] ], "additional_components": [ "Q95Y97", "WBGene00019767", "O02115", "WBGene00003955", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "G5EFY1", "WBGene00018721", "Q95Y97", "WBGene00019767", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "O02115", "WBGene00003955", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "G5EFY1", "WBGene00018721", "Q95Y97", "WBGene00019767", "O02115", "WBGene00003955", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "G5EFY1", "WBGene00018721" ] }, "reaction_10554412": { "compartment": "compartment_7660", "id": "reaction_10554412", "reactome": "R-CEL-5654985", "name": "SPRTN recruits VCP to monoUb:K164-PCNA associated with POLH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10554408", "species_10554392" ], "products": [ "species_10554410" ], "modifiers": [], "additional_components": [ "Q95QZ9", "WBGene00019121", "Q19584", "WBGene00006733", "P54812", "WBGene00008053", "Q22557", "WBGene00011834", "Q95Y97", "WBGene00019767", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "O02115", "WBGene00003955", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "G5EFY1", "WBGene00018721", "Q22557", "WBGene00011834", "Q95Y97", "WBGene00019767", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "O02115", "WBGene00003955", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "G5EFY1", "WBGene00018721", "Q95QZ9", "WBGene00019121", "Q19584", "WBGene00006733", "P54812", "WBGene00008053" ] }, "reaction_10554414": { "compartment": "compartment_7660", "id": "reaction_10554414", "reactome": "R-CEL-5654986", "name": "SPRTN binds monoUb:K164-PCNA associated with POLH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508778", "species_10554390" ], "products": [ "species_10554392" ], "modifiers": [], "additional_components": [ "Q95Y97", "WBGene00019767", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "O02115", "WBGene00003955", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "G5EFY1", "WBGene00018721", "WBGene00011834", "Q22557", "WBGene00011834", "Q95Y97", "WBGene00019767", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "O02115", "WBGene00003955", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "G5EFY1", "WBGene00018721" ] }, "reaction_10556021": { "compartment": "compartment_7660", "id": "reaction_10556021", "reactome": "R-CEL-5687664", "name": "FEN1 cleaves displaced ssDNA flaps during MMEJ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10556014" ], "products": [ "species_68454", "species_10502724", "species_10556018" ], "modifiers": [ [ "species_10556014", "catalyst" ] ], "additional_components": [ "Q9N3T2", "WBGene00000794", "Q18606", "WBGene00008082", "Q23255", "WBGene00003405", "O44199", "WBGene00004296", "WBGene00000794", "Q23255", "WBGene00003405", "O44199", "WBGene00004296", "Q18606", "WBGene00008082", "Q9N3T2", "WBGene00000794", "Q18606", "WBGene00008082", "Q23255", "WBGene00003405", "O44199", "WBGene00004296" ] }, "reaction_10556008": { "compartment": "compartment_7660", "id": "reaction_10556008", "reactome": "R-CEL-5687464", "name": "MRN and RBBP8 resect DNA DSBs in MMEJ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10556001" ], "products": [ "species_30555", "species_10556005" ], "modifiers": [ [ "species_10556001", "catalyst" ] ], "additional_components": [ "Q18606", "WBGene00008082", "Q23255", "WBGene00003405", "O44199", "WBGene00004296", "Q23255", "WBGene00003405", "O44199", "WBGene00004296", "Q18606", "WBGene00008082", "Q18606", "WBGene00008082", "Q23255", "WBGene00003405", "O44199", "WBGene00004296" ] }, "reaction_10519896": { "compartment": "compartment_5460", "id": "reaction_10519896", "reactome": "R-CEL-380608", "name": "5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113526", "species_380598" ], "products": [ "species_113529", "species_380593", "species_29362" ], "modifiers": [ [ "species_10504264", "catalyst" ] ], "additional_components": [ "Q20780", "WBGene00000107" ] }, "reaction_10524588": { "compartment": "compartment_876", "id": "reaction_10524588", "reactome": "R-CEL-444008", "name": "SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_188972", "species_114523", "species_74113" ], "products": [ "species_209914", "species_83910", "species_352022" ], "modifiers": [ [ "species_10524585", "catalyst" ] ], "additional_components": [ "WBGene00003387" ] }, "reaction_10517995": { "compartment": "compartment_70101", "id": "reaction_10517995", "reactome": "R-CEL-350769", "name": "trans-Golgi Network Coat Activation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10517983", "species_29438" ], "products": [ "species_29420", "species_10517987" ], "modifiers": [ [ "species_10517992", "catalyst" ] ], "additional_components": [ "species_29420", "G5EFK4", "WBGene00000183", "G5EFK4", "WBGene00000183", "species_29438", "WBGene00007703" ] }, "reaction_10522258": { "compartment": "compartment_20699", "id": "reaction_10522258", "reactome": "R-CEL-421831", "name": "trans-Golgi Network Coat Assembly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10522248", "species_10512231", "species_10522246", "species_10522240" ], "products": [ "species_10517983", "species_29372", "species_10522256" ], "modifiers": [], "additional_components": [ "WBGene00001130", "WBGene00006791", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "Q8WQB3", "WBGene00000158", "O01755", "WBGene00000150", "P35602", "WBGene00006829", "O16369", "WBGene00000159", "Q9N4F3", "WBGene00000160", "P51485", "WBGene00000195", "G5EFK4", "WBGene00000183", "species_29438", "species_29420", "G5EFK4", "WBGene00000183", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "B1V8A0", "WBGene00006791", "Q8WQB3", "WBGene00000158", "O01755", "WBGene00000150", "P35602", "WBGene00006829", "O16369", "WBGene00000159", "Q9N4F3", "WBGene00000160", "P51485", "WBGene00000195", "P39055", "WBGene00001130" ] }, "reaction_10522389": { "compartment": "compartment_70101", "id": "reaction_10522389", "reactome": "R-CEL-421835", "name": "trans-Golgi Network Vesicle Scission", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10522256" ], "products": [ "species_29372", "species_29420", "species_10522248", "species_10512231", "species_10522386" ], "modifiers": [ [ "species_10522256", "catalyst" ] ], "additional_components": [ "P34574", "WBGene00011867", "P90961", "WBGene00020246", "B1V8A0", "WBGene00006791", "Q8WQB3", "WBGene00000158", "O01755", "WBGene00000150", "P35602", "WBGene00006829", "O16369", "WBGene00000159", "Q9N4F3", "WBGene00000160", "P51485", "WBGene00000195", "P39055", "WBGene00001130", "WBGene00001130", "WBGene00006791", "P51485", "WBGene00000195", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "P35602", "WBGene00006829", "O01755", "WBGene00000150", "O16369", "WBGene00000159", "Q8WQB3", "WBGene00000158", "Q9N4F3", "WBGene00000160", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "B1V8A0", "WBGene00006791", "Q8WQB3", "WBGene00000158", "O01755", "WBGene00000150", "P35602", "WBGene00006829", "O16369", "WBGene00000159", "Q9N4F3", "WBGene00000160", "P51485", "WBGene00000195", "P39055", "WBGene00001130" ] }, "reaction_10566464": { "compartment": "compartment_876", "id": "reaction_10566464", "reactome": "R-CEL-8867756", "name": "CLASP proteins and cargo are recruited to the nascent clathrin-coated pit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10566399", "species_10565777" ], "products": [ "species_10566401" ], "modifiers": [], "additional_components": [ "Q95XH1", "WBGene00022077", "G5EBK2", "WBGene00014084", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q19767", "WBGene00004898", "Q94057", "WBGene00044062", "Q9XZI6", "WBGene00006751", "Q9N532", "WBGene00003238", "G5EDV1", "WBGene00003006", "P34889", "WBGene00000858", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "Q9U7D5", "WBGene00001519", "P51485", "WBGene00000195", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "P90761", "WBGene00006777", "Q9BIF4", "WBGene00001224", "Q18453", "WBGene00004682", "Q9BI71", "WBGene00001329", "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "B1V8A0", "WBGene00006791", "P29355", "WBGene00004774", "Q17796", "WBGene00004101", "O01498", "WBGene00004109", "Q21496", "WBGene00020010", "Q21948", "WBGene00020010", "A0A486WXX8", "WBGene00000894", "Q95QV2", "WBGene00000477", "Q19625", "WBGene00003412", "P34711", "WBGene00006756", "Q9XTT3", "WBGene00013039", "G5ECQ3", "WBGene00004762", "Q20483", "WBGene00018516", "Q9BIF4", "WBGene00001224", "species_179856", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "Q9TXS0", "WBGene00018974", "Q9N489", "WBGene00022453", "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "Q19123", "WBGene00000157", "P35603", "WBGene00001082", "A0A0K3AS36", "Y116A8C.36d", "G5ECQ3", "WBGene00004762", "Q20483", "WBGene00018516", "Q9BIF4", "WBGene00001224", "species_179856", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "Q9TXS0", "WBGene00018974", "Q9N489", "WBGene00022453", "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "Q19123", "WBGene00000157", "P35603", "WBGene00001082", "A0A0K3AS36", "Y116A8C.36d", "Q95XH1", "WBGene00022077", "G5EBK2", "WBGene00014084", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q19767", "WBGene00004898", "Q94057", "WBGene00044062", "Q9XZI6", "WBGene00006751", "Q9N532", "WBGene00003238", "G5EDV1", "WBGene00003006", "P34889", "WBGene00000858", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "Q9U7D5", "WBGene00001519", "P51485", "WBGene00000195", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "P90761", "WBGene00006777", "Q18453", "WBGene00004682", "Q9BI71", "WBGene00001329", "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "B1V8A0", "WBGene00006791", "P29355", "WBGene00004774", "Q17796", "WBGene00004101", "O01498", "WBGene00004109", "Q21496", "WBGene00020010", "Q21948", "WBGene00020010", "A0A486WXX8", "WBGene00000894", "Q95QV2", "WBGene00000477", "Q19625", "WBGene00003412", "P34711", "WBGene00006756", "Q9XTT3", "WBGene00013039" ] }, "reaction_10567111": { "compartment": "compartment_24339", "id": "reaction_10567111", "reactome": "R-CEL-8871193", "name": "Dissociation of AAK1 and dephosphorylation of AP-2 mu2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10567109" ], "products": [ "species_10566724", "species_10565728" ], "modifiers": [], "additional_components": [ "P91857", "WBGene00004268", "species_29420", "Q9GYH7", "WBGene00004377", "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q9XTT3", "WBGene00013039", "Q19625", "WBGene00003412", "Q95QV2", "WBGene00000477", "P34711", "WBGene00006756", "Q21496", "WBGene00020010", "Q21948", "WBGene00020010", "A0A486WXX8", "WBGene00000894", "O02495", "WBGene00004897", "G5EBK2", "WBGene00014084", "P34351", "WBGene00004899", "Q19767", "WBGene00004898", "Q94057", "WBGene00044062", "Q95XH1", "WBGene00022077", "Q9XZI6", "WBGene00006751", "Q9BIF4", "WBGene00001224", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "B1V8A0", "WBGene00006791", "Q18453", "WBGene00004682", "Q9BI71", "WBGene00001329", "P29355", "WBGene00004774", "Q17796", "WBGene00004101", "O01498", "WBGene00004109", "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "P34889", "WBGene00000858", "G5EDV1", "WBGene00003006", "Q9N532", "WBGene00003238", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "Q9U7D5", "WBGene00001519", "P51485", "WBGene00000195", "P90761", "WBGene00006777", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "Q02328", "WBGene00022717", "G5ECQ3", "WBGene00004762", "Q20483", "WBGene00018516", "P0DM42", "WBGene00000065", "P10984", "WBGene00000064", "P10986", "WBGene00000066", "P0DM41", "WBGene00000063", "species_29358", "Q19253", "WBGene00017298", "P58798", "WBGene00000204", "A0A3P6PCS5", "WBGene00000201", "Q9N4I0", "WBGene00000199", "Q8WTM6", "WBGene00021170", "P53489", "WBGene00000200", "Q9XWV3", "WBGene00000203", "O61861", "WBGene00000205", "P91167", "WBGene00016729", "species_1806234", "Q21004", "WBGene00010272", "Q9XUS7", "WBGene00010663", "Q9TXS0", "WBGene00018974", "A0A486WXP9", "WBGene00001043", "Q6AHQ8", "WBGene00018467", "Q9N489", "WBGene00022453", "Q8I4E2", "WBGene00003086", "A0A0K3AS36", "Y116A8C.36d", "P39055", "WBGene00001130", "O17590", "WBGene00007620", "G5ECL2", "WBGene00006763", "P91857", "WBGene00004268", "species_29438", "Q9GYH7", "WBGene00004377", "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q9XTT3", "WBGene00013039", "Q19625", "WBGene00003412", "Q95QV2", "WBGene00000477", "P34711", "WBGene00006756", "Q21496", "WBGene00020010", "Q21948", "WBGene00020010", "A0A486WXX8", "WBGene00000894", "O02495", "WBGene00004897", "G5EBK2", "WBGene00014084", "P34351", "WBGene00004899", "Q19767", "WBGene00004898", "Q94057", "WBGene00044062", "Q95XH1", "WBGene00022077", "Q9XZI6", "WBGene00006751", "Q9BIF4", "WBGene00001224", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "B1V8A0", "WBGene00006791", "Q18453", "WBGene00004682", "Q9BI71", "WBGene00001329", "P29355", "WBGene00004774", "Q17796", "WBGene00004101", "O01498", "WBGene00004109", "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "P34889", "WBGene00000858", "G5EDV1", "WBGene00003006", "Q9N532", "WBGene00003238", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "Q9U7D5", "WBGene00001519", "P51485", "WBGene00000195", "P90761", "WBGene00006777", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "Q02328", "WBGene00022717", "P0DM42", "WBGene00000065", "P10984", "WBGene00000064", "P10986", "WBGene00000066", "P0DM41", "WBGene00000063", "species_29358", "Q19253", "WBGene00017298", "P58798", "WBGene00000204", "A0A3P6PCS5", "WBGene00000201", "Q9N4I0", "WBGene00000199", "Q8WTM6", "WBGene00021170", "P53489", "WBGene00000200", "Q9XWV3", "WBGene00000203", "O61861", "WBGene00000205", "P91167", "WBGene00016729", "species_1806234", "Q21004", "WBGene00010272", "Q9XUS7", "WBGene00010663", "Q9TXS0", "WBGene00018974", "A0A486WXP9", "WBGene00001043", "Q6AHQ8", "WBGene00018467", "Q9N489", "WBGene00022453", "Q8I4E2", "WBGene00003086", "A0A0K3AS36", "Y116A8C.36d", "P39055", "WBGene00001130", "species_29420", "O17590", "WBGene00007620", "G5ECL2", "WBGene00006763", "G5ECQ3", "WBGene00004762", "Q20483", "WBGene00018516" ] }, "reaction_10565769": { "compartment": "compartment_876", "id": "reaction_10565769", "reactome": "R-CEL-8856808", "name": "Recruitment of AP-2 complex and clathrin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10548814", "species_10565757", "species_10565755", "species_10522246", "species_10565728" ], "products": [ "species_10565761" ], "modifiers": [ [ "species_10565767", "catalyst" ] ], "additional_components": [ "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "WBGene00022453", "Q9BIF4", "WBGene00001224", "species_179856", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q9TXS0", "WBGene00018974", "A0A0K3AS36", "Y116A8C.36d", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "G5ECQ3", "WBGene00004762", "Q20483", "WBGene00018516", "G5ECQ3", "WBGene00004762", "Q20483", "WBGene00018516", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "Q9BIF4", "WBGene00001224", "species_179856", "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q9TXS0", "WBGene00018974", "A0A0K3AS36", "Y116A8C.36d", "Q9N489", "WBGene00022453", "Q9U2S4", "WBGene00000184", "species_29438", "P90904", "WBGene00010500" ] }, "reaction_10567113": { "compartment": "compartment_24339", "id": "reaction_10567113", "reactome": "R-CEL-8871194", "name": "RAB5 and GAPVD1 bind AP-2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10566661", "species_10567107" ], "products": [ "species_10567109" ], "modifiers": [], "additional_components": [ "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q9XTT3", "WBGene00013039", "Q19625", "WBGene00003412", "Q95QV2", "WBGene00000477", "P34711", "WBGene00006756", "Q21496", "WBGene00020010", "Q21948", "WBGene00020010", "A0A486WXX8", "WBGene00000894", "O02495", "WBGene00004897", "G5EBK2", "WBGene00014084", "P34351", "WBGene00004899", "Q19767", "WBGene00004898", "Q94057", "WBGene00044062", "Q95XH1", "WBGene00022077", "Q9XZI6", "WBGene00006751", "Q9BIF4", "WBGene00001224", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "B1V8A0", "WBGene00006791", "Q18453", "WBGene00004682", "Q9BI71", "WBGene00001329", "P29355", "WBGene00004774", "Q17796", "WBGene00004101", "O01498", "WBGene00004109", "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "P34889", "WBGene00000858", "G5EDV1", "WBGene00003006", "Q9N532", "WBGene00003238", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "Q9U7D5", "WBGene00001519", "P51485", "WBGene00000195", "P90761", "WBGene00006777", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "Q02328", "WBGene00022717", "G5ECQ3", "WBGene00004762", "Q20483", "WBGene00018516", "P0DM42", "WBGene00000065", "P10984", "WBGene00000064", "P10986", "WBGene00000066", "P0DM41", "WBGene00000063", "species_29358", "Q19253", "WBGene00017298", "P58798", "WBGene00000204", "A0A3P6PCS5", "WBGene00000201", "Q9N4I0", "WBGene00000199", "Q8WTM6", "WBGene00021170", "P53489", "WBGene00000200", "Q9XWV3", "WBGene00000203", "O61861", "WBGene00000205", "P91167", "WBGene00016729", "species_1806234", "Q21004", "WBGene00010272", "Q9XUS7", "WBGene00010663", "Q9TXS0", "WBGene00018974", "A0A486WXP9", "WBGene00001043", "Q6AHQ8", "WBGene00018467", "Q9N489", "WBGene00022453", "Q8I4E2", "WBGene00003086", "A0A0K3AS36", "Y116A8C.36d", "P39055", "WBGene00001130", "species_29420", "O17590", "WBGene00007620", "G5ECL2", "WBGene00006763", "P91857", "WBGene00004268", "species_29420", "Q9GYH7", "WBGene00004377", "P91857", "WBGene00004268", "species_29420", "Q9GYH7", "WBGene00004377", "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q9XTT3", "WBGene00013039", "Q19625", "WBGene00003412", "Q95QV2", "WBGene00000477", "P34711", "WBGene00006756", "Q21496", "WBGene00020010", "Q21948", "WBGene00020010", "A0A486WXX8", "WBGene00000894", "O02495", "WBGene00004897", "G5EBK2", "WBGene00014084", "P34351", "WBGene00004899", "Q19767", "WBGene00004898", "Q94057", "WBGene00044062", "Q95XH1", "WBGene00022077", "Q9XZI6", "WBGene00006751", "Q9BIF4", "WBGene00001224", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "B1V8A0", "WBGene00006791", "Q18453", "WBGene00004682", "Q9BI71", "WBGene00001329", "P29355", "WBGene00004774", "Q17796", "WBGene00004101", "O01498", "WBGene00004109", "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "P34889", "WBGene00000858", "G5EDV1", "WBGene00003006", "Q9N532", "WBGene00003238", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "Q9U7D5", "WBGene00001519", "P51485", "WBGene00000195", "P90761", "WBGene00006777", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "Q02328", "WBGene00022717", "G5ECQ3", "WBGene00004762", "Q20483", "WBGene00018516", "P0DM42", "WBGene00000065", "P10984", "WBGene00000064", "P10986", "WBGene00000066", "P0DM41", "WBGene00000063", "species_29358", "Q19253", "WBGene00017298", "P58798", "WBGene00000204", "A0A3P6PCS5", "WBGene00000201", "Q9N4I0", "WBGene00000199", "Q8WTM6", "WBGene00021170", "P53489", "WBGene00000200", "Q9XWV3", "WBGene00000203", "O61861", "WBGene00000205", "P91167", "WBGene00016729", "species_1806234", "Q21004", "WBGene00010272", "Q9XUS7", "WBGene00010663", "Q9TXS0", "WBGene00018974", "A0A486WXP9", "WBGene00001043", "Q6AHQ8", "WBGene00018467", "Q9N489", "WBGene00022453", "Q8I4E2", "WBGene00003086", "A0A0K3AS36", "Y116A8C.36d", "P39055", "WBGene00001130", "O17590", "WBGene00007620", "G5ECL2", "WBGene00006763" ] }, "reaction_10567115": { "compartment": "compartment_876", "id": "reaction_10567115", "reactome": "R-CEL-8871196", "name": "Initial binding of AP-2 and clathrin to PI(4,5)P2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10548814", "species_10522246", "species_179856" ], "products": [ "species_10565751" ], "modifiers": [], "additional_components": [ "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "species_179856", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "P35603", "WBGene00001082", "Q19123", "WBGene00000157" ] }, "reaction_10566475": { "compartment": "compartment_876", "id": "reaction_10566475", "reactome": "R-CEL-8868066", "name": "PIP5K1C phosphorylates PI(4)P to PI(4,5)P2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_392417" ], "products": [ "species_29370", "species_179856" ], "modifiers": [ [ "species_10521254", "catalyst" ] ], "additional_components": [ "WBGene00004087" ] }, "reaction_10566666": { "compartment": "compartment_24339", "id": "reaction_10566666", "reactome": "R-CEL-8868658", "name": "HSPA8-mediated ATP hydrolysis promotes vesicle uncoating", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10566659" ], "products": [ "species_29372", "species_10566663", "species_10566661" ], "modifiers": [ [ "species_10566659", "catalyst" ] ], "additional_components": [ "Q02328", "WBGene00022717", "G5ECQ3", "WBGene00004762", "Q20483", "WBGene00018516", "Q19253", "WBGene00017298", "P58798", "WBGene00000204", "A0A3P6PCS5", "WBGene00000201", "Q9N4I0", "WBGene00000199", "species_29358", "Q8WTM6", "WBGene00021170", "P53489", "WBGene00000200", "Q9XWV3", "WBGene00000203", "O61861", "WBGene00000205", "P91167", "WBGene00016729", "Q9XUS7", "WBGene00010663", "B1V8A0", "WBGene00006791", "Q9TXS0", "WBGene00018974", "Q9N489", "WBGene00022453", "A0A0K3AS36", "Y116A8C.36d", "P39055", "WBGene00001130", "species_29420", "O17590", "WBGene00007620", "G5ECL2", "WBGene00006763", "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q9XTT3", 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"A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "Q9U7D5", "WBGene00001519", "P51485", "WBGene00000195", "P90761", "WBGene00006777", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "P0DM42", "WBGene00000065", "P10984", "WBGene00000064", "P10986", "WBGene00000066", "P0DM41", "WBGene00000063", "species_1806234", "Q21004", "WBGene00010272", "P09446", "WBGene00002005", "A0A486WXP9", "WBGene00001043", "Q6AHQ8", "WBGene00018467", "Q8I4E2", "WBGene00003086" ] }, "reaction_10566477": { "compartment": "compartment_876", "id": "reaction_10566477", "reactome": "R-CEL-8868071", "name": "Clathrin recruits PIK3C2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10537176", "species_10566401" ], "products": [ "species_10566403" ], "modifiers": [], "additional_components": [ "WBGene00009552", "G5ECQ3", "WBGene00004762", "Q20483", "WBGene00018516", "Q9BIF4", "WBGene00001224", "species_179856", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "Q9TXS0", "WBGene00018974", "Q9N489", "WBGene00022453", "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "Q19123", "WBGene00000157", "P35603", "WBGene00001082", "A0A0K3AS36", "Y116A8C.36d", "Q95XH1", "WBGene00022077", "G5EBK2", "WBGene00014084", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q19767", "WBGene00004898", "Q94057", "WBGene00044062", "Q9XZI6", "WBGene00006751", "Q9N532", "WBGene00003238", "G5EDV1", "WBGene00003006", "P34889", "WBGene00000858", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "Q9U7D5", "WBGene00001519", "P51485", "WBGene00000195", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "P90761", "WBGene00006777", "Q18453", "WBGene00004682", "Q9BI71", "WBGene00001329", "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "B1V8A0", "WBGene00006791", "P29355", "WBGene00004774", "Q17796", "WBGene00004101", "O01498", "WBGene00004109", "Q21496", "WBGene00020010", "Q21948", "WBGene00020010", "A0A486WXX8", "WBGene00000894", "Q95QV2", "WBGene00000477", "Q19625", "WBGene00003412", "P34711", "WBGene00006756", "Q9XTT3", "WBGene00013039", "G5ECQ3", "WBGene00004762", "Q20483", "WBGene00018516", "Q9BIF4", "WBGene00001224", "species_179856", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "Q9TXS0", "WBGene00018974", "Q9N489", "WBGene00022453", "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "Q19123", "WBGene00000157", "P35603", "WBGene00001082", "A0A0K3AS36", "Y116A8C.36d", "Q95XH1", "WBGene00022077", "G5EBK2", "WBGene00014084", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q19767", "WBGene00004898", "Q94057", "WBGene00044062", "Q9XZI6", "WBGene00006751", "Q9N532", "WBGene00003238", "G5EDV1", "WBGene00003006", "P34889", "WBGene00000858", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "Q9U7D5", "WBGene00001519", "P51485", "WBGene00000195", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "P90761", "WBGene00006777", "Q18453", "WBGene00004682", "Q9BI71", "WBGene00001329", "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "B1V8A0", "WBGene00006791", "P29355", "WBGene00004774", "Q17796", "WBGene00004101", "O01498", "WBGene00004109", "Q21496", "WBGene00020010", "Q21948", "WBGene00020010", "A0A486WXX8", "WBGene00000894", "Q95QV2", "WBGene00000477", "Q19625", "WBGene00003412", "P34711", "WBGene00006756", "Q9XTT3", "WBGene00013039", "G5EDY0", "WBGene00009552" ] }, "reaction_10566508": { "compartment": "compartment_876", "id": "reaction_10566508", "reactome": "R-CEL-8868236", "name": "BAR domain proteins recruit dynamin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10566504", "species_10566502" ], "products": [ "species_10566506" ], "modifiers": [], "additional_components": [ "P39055", "WBGene00001130", "species_29438", "Q02328", "WBGene00022717", "P0DM42", "WBGene00000065", "P10984", "WBGene00000064", "P10986", "WBGene00000066", "P0DM41", "WBGene00000063", "species_29358", "P58798", "WBGene00000204", "A0A3P6PCS5", "WBGene00000201", "Q9N4I0", "WBGene00000199", "Q8WTM6", "WBGene00021170", "P53489", "WBGene00000200", "Q9XWV3", "WBGene00000203", "O61861", "WBGene00000205", "P91167", "WBGene00016729", "Q19253", "WBGene00017298", "Q9XUS7", "WBGene00010663", "B1V8A0", "WBGene00006791", "Q21004", "WBGene00010272", "Q9BIF4", "WBGene00001224", "G5ECQ3", "WBGene00004762", "Q20483", "WBGene00018516", "species_179856", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "Q9TXS0", "WBGene00018974", "Q9N489", "WBGene00022453", "Q95XH1", "WBGene00022077", "G5EBK2", "WBGene00014084", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q19767", "WBGene00004898", "Q94057", "WBGene00044062", "Q9XZI6", "WBGene00006751", "Q9N532", "WBGene00003238", "G5EDV1", "WBGene00003006", "P34889", "WBGene00000858", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "Q9U7D5", "WBGene00001519", "P51485", "WBGene00000195", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "P90761", "WBGene00006777", "Q18453", "WBGene00004682", "Q9BI71", "WBGene00001329", "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "P29355", "WBGene00004774", "Q17796", "WBGene00004101", "O01498", "WBGene00004109", "Q21496", "WBGene00020010", "Q21948", "WBGene00020010", "A0A486WXX8", "WBGene00000894", "Q95QV2", "WBGene00000477", "Q19625", "WBGene00003412", "P34711", "WBGene00006756", "Q9XTT3", "WBGene00013039", "A0A0K3AS36", "Y116A8C.36d", "Q6AHQ8", "WBGene00018467", "Q8I4E2", "WBGene00003086", "Q02328", "WBGene00022717", "P0DM42", "WBGene00000065", "P10984", "WBGene00000064", "P10986", "WBGene00000066", "P0DM41", "WBGene00000063", "species_29358", "P58798", "WBGene00000204", "A0A3P6PCS5", "WBGene00000201", "Q9N4I0", "WBGene00000199", "Q8WTM6", "WBGene00021170", "P53489", "WBGene00000200", "Q9XWV3", "WBGene00000203", "O61861", "WBGene00000205", "P91167", "WBGene00016729", "Q19253", "WBGene00017298", "Q9XUS7", "WBGene00010663", "B1V8A0", "WBGene00006791", "Q21004", "WBGene00010272", "Q9BIF4", "WBGene00001224", "G5ECQ3", "WBGene00004762", "Q20483", "WBGene00018516", "species_179856", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "Q9TXS0", "WBGene00018974", "Q9N489", "WBGene00022453", "Q95XH1", "WBGene00022077", "G5EBK2", "WBGene00014084", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q19767", "WBGene00004898", "Q94057", "WBGene00044062", "Q9XZI6", "WBGene00006751", "Q9N532", "WBGene00003238", "G5EDV1", "WBGene00003006", "P34889", "WBGene00000858", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "Q9U7D5", "WBGene00001519", "P51485", "WBGene00000195", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "P90761", "WBGene00006777", "Q18453", "WBGene00004682", "Q9BI71", "WBGene00001329", "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "P29355", "WBGene00004774", "Q17796", "WBGene00004101", "O01498", "WBGene00004109", "Q21496", "WBGene00020010", "Q21948", "WBGene00020010", "A0A486WXX8", "WBGene00000894", "Q95QV2", "WBGene00000477", "Q19625", "WBGene00003412", "P34711", "WBGene00006756", "Q9XTT3", "WBGene00013039", "A0A0K3AS36", "Y116A8C.36d", "Q6AHQ8", "WBGene00018467", "Q8I4E2", "WBGene00003086", "P39055", "WBGene00001130", "species_29438" ] }, "reaction_10566480": { "compartment": "compartment_876", "id": "reaction_10566480", "reactome": "R-CEL-8868072", "name": "Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_392417" ], "products": [ "species_29370", "species_202247" ], "modifiers": [ [ "species_10566403", "catalyst" ] ], "additional_components": [ "G5ECQ3", "WBGene00004762", "Q20483", "WBGene00018516", "Q9BIF4", "WBGene00001224", "species_179856", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "Q9TXS0", "WBGene00018974", "Q9N489", "WBGene00022453", "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "Q19123", "WBGene00000157", "P35603", "WBGene00001082", "A0A0K3AS36", "Y116A8C.36d", "Q95XH1", "WBGene00022077", "G5EBK2", "WBGene00014084", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q19767", "WBGene00004898", "Q94057", "WBGene00044062", "Q9XZI6", "WBGene00006751", "Q9N532", "WBGene00003238", "G5EDV1", "WBGene00003006", "P34889", "WBGene00000858", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "Q9U7D5", "WBGene00001519", "P51485", "WBGene00000195", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "P90761", "WBGene00006777", "Q18453", "WBGene00004682", "Q9BI71", "WBGene00001329", "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "B1V8A0", "WBGene00006791", "P29355", "WBGene00004774", "Q17796", "WBGene00004101", "O01498", "WBGene00004109", "Q21496", "WBGene00020010", "Q21948", "WBGene00020010", "A0A486WXX8", "WBGene00000894", "Q95QV2", "WBGene00000477", "Q19625", "WBGene00003412", "P34711", "WBGene00006756", "Q9XTT3", "WBGene00013039", "G5EDY0", "WBGene00009552" ] }, "reaction_10566672": { "compartment": "compartment_24339", "id": "reaction_10566672", "reactome": "R-CEL-8868659", "name": "Clathrin recruits auxilins to the clathrin-coated vesicle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10566668", "species_10522393" ], "products": [ "species_10566670" ], "modifiers": [], "additional_components": [ "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q9XTT3", "WBGene00013039", "Q19625", "WBGene00003412", "Q95QV2", "WBGene00000477", "P34711", "WBGene00006756", "Q21496", "WBGene00020010", "Q21948", "WBGene00020010", "A0A486WXX8", "WBGene00000894", "O02495", "WBGene00004897", "G5EBK2", "WBGene00014084", "P34351", "WBGene00004899", "Q19767", "WBGene00004898", "Q94057", "WBGene00044062", "Q95XH1", "WBGene00022077", "Q9XZI6", "WBGene00006751", "Q9BIF4", "WBGene00001224", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "B1V8A0", "WBGene00006791", "Q18453", "WBGene00004682", "Q9BI71", "WBGene00001329", "P29355", "WBGene00004774", "Q17796", "WBGene00004101", "O01498", "WBGene00004109", "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "P34889", "WBGene00000858", "G5EDV1", "WBGene00003006", "Q9N532", "WBGene00003238", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "Q9U7D5", "WBGene00001519", "P51485", "WBGene00000195", "P90761", "WBGene00006777", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "Q02328", "WBGene00022717", "G5ECQ3", "WBGene00004762", "Q20483", "WBGene00018516", "P0DM42", "WBGene00000065", "P10984", "WBGene00000064", "P10986", "WBGene00000066", "P0DM41", "WBGene00000063", "species_29358", "Q19253", "WBGene00017298", "P58798", "WBGene00000204", "A0A3P6PCS5", "WBGene00000201", "Q9N4I0", "WBGene00000199", "Q8WTM6", "WBGene00021170", "P53489", "WBGene00000200", "Q9XWV3", "WBGene00000203", "O61861", "WBGene00000205", "P91167", "WBGene00016729", "species_1806234", "Q21004", "WBGene00010272", "Q9XUS7", "WBGene00010663", "Q9TXS0", "WBGene00018974", "Q6AHQ8", "WBGene00018467", "Q9N489", "WBGene00022453", "Q8I4E2", "WBGene00003086", "A0A0K3AS36", "Y116A8C.36d", "P39055", "WBGene00001130", "species_29420", "O17590", "WBGene00007620", "G5ECL2", "WBGene00006763", "WBGene00001043", "Q02328", "WBGene00022717", "G5ECQ3", "WBGene00004762", "Q20483", "WBGene00018516", "Q19253", "WBGene00017298", "P58798", "WBGene00000204", "A0A3P6PCS5", "WBGene00000201", "Q9N4I0", "WBGene00000199", "species_29358", "Q8WTM6", "WBGene00021170", "P53489", "WBGene00000200", "Q9XWV3", "WBGene00000203", "O61861", "WBGene00000205", "P91167", "WBGene00016729", "Q9XUS7", "WBGene00010663", "B1V8A0", "WBGene00006791", "Q9TXS0", "WBGene00018974", "Q9N489", "WBGene00022453", "A0A0K3AS36", "Y116A8C.36d", "P39055", "WBGene00001130", "species_29420", "O17590", "WBGene00007620", "G5ECL2", "WBGene00006763", "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q9XTT3", "WBGene00013039", "Q19625", "WBGene00003412", "Q95QV2", "WBGene00000477", "P34711", "WBGene00006756", "Q21496", "WBGene00020010", "Q21948", "WBGene00020010", "A0A486WXX8", "WBGene00000894", "O02495", "WBGene00004897", "G5EBK2", "WBGene00014084", "P34351", "WBGene00004899", "Q19767", "WBGene00004898", "Q94057", "WBGene00044062", "Q95XH1", "WBGene00022077", "Q9XZI6", "WBGene00006751", "Q9BIF4", "WBGene00001224", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "Q18453", "WBGene00004682", "Q9BI71", "WBGene00001329", "P29355", "WBGene00004774", "Q17796", "WBGene00004101", "O01498", "WBGene00004109", "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "P34889", "WBGene00000858", "G5EDV1", "WBGene00003006", "Q9N532", "WBGene00003238", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "Q9U7D5", "WBGene00001519", "P51485", "WBGene00000195", "P90761", "WBGene00006777", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "P0DM42", "WBGene00000065", "P10984", "WBGene00000064", "P10986", "WBGene00000066", "P0DM41", "WBGene00000063", "species_1806234", "Q21004", "WBGene00010272", "A0A486WXP9", "WBGene00001043", "Q6AHQ8", "WBGene00018467", "Q8I4E2", "WBGene00003086" ] }, "reaction_10566674": { "compartment": "compartment_24339", "id": "reaction_10566674", "reactome": "R-CEL-8868660", "name": "Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10565761" ], "products": [ "species_29370", "species_10565777" ], "modifiers": [ [ "species_10565761", "catalyst" ] ], "additional_components": [ "G5ECQ3", "WBGene00004762", "Q20483", "WBGene00018516", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "Q9BIF4", "WBGene00001224", "species_179856", "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q9TXS0", "WBGene00018974", "A0A0K3AS36", "Y116A8C.36d", "Q9N489", "WBGene00022453", "G5ECQ3", "WBGene00004762", "Q20483", "WBGene00018516", "Q9BIF4", "WBGene00001224", "species_179856", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "Q9TXS0", "WBGene00018974", "Q9N489", "WBGene00022453", "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "Q19123", "WBGene00000157", "P35603", "WBGene00001082", "A0A0K3AS36", "Y116A8C.36d", "G5ECQ3", "WBGene00004762", "Q20483", "WBGene00018516", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "Q9BIF4", "WBGene00001224", "species_179856", "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q9TXS0", "WBGene00018974", "A0A0K3AS36", "Y116A8C.36d", "Q9N489", "WBGene00022453" ] }, "reaction_10566523": { "compartment": "compartment_876", "id": "reaction_10566523", "reactome": "R-CEL-8868648", "name": "SYNJ hydrolyze PI(4,5)P2 to PI(4)P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10566518" ], "products": [ "species_29372", "species_10566520" ], "modifiers": [ [ "species_10566518", "catalyst" ] ], "additional_components": [ "Q02328", "WBGene00022717", "P0DM42", "WBGene00000065", "P10984", "WBGene00000064", "P10986", "WBGene00000066", "P0DM41", "WBGene00000063", "species_29358", "P58798", "WBGene00000204", "A0A3P6PCS5", "WBGene00000201", "Q9N4I0", "WBGene00000199", "Q8WTM6", "WBGene00021170", "P53489", "WBGene00000200", "Q9XWV3", "WBGene00000203", "O61861", "WBGene00000205", "P91167", "WBGene00016729", "Q19253", "WBGene00017298", "Q9XUS7", "WBGene00010663", "B1V8A0", "WBGene00006791", "Q21004", "WBGene00010272", "Q9BIF4", "WBGene00001224", "G5ECQ3", "WBGene00004762", "Q20483", "WBGene00018516", "species_179856", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "Q9TXS0", "WBGene00018974", "Q9N489", "WBGene00022453", "Q95XH1", "WBGene00022077", 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10537150", "species_10566506" ], "products": [ "species_10566518" ], "modifiers": [], "additional_components": [ "O17590", "WBGene00007620", "G5ECL2", "WBGene00006763", "Q02328", "WBGene00022717", "P0DM42", "WBGene00000065", "P10984", "WBGene00000064", "P10986", "WBGene00000066", "P0DM41", "WBGene00000063", "species_29358", "P58798", "WBGene00000204", "A0A3P6PCS5", "WBGene00000201", "Q9N4I0", "WBGene00000199", "Q8WTM6", "WBGene00021170", "P53489", "WBGene00000200", "Q9XWV3", "WBGene00000203", "O61861", "WBGene00000205", "P91167", "WBGene00016729", "Q19253", "WBGene00017298", "Q9XUS7", "WBGene00010663", "B1V8A0", "WBGene00006791", "Q21004", "WBGene00010272", "Q9BIF4", "WBGene00001224", "G5ECQ3", "WBGene00004762", "Q20483", "WBGene00018516", "species_179856", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "Q9TXS0", "WBGene00018974", "Q9N489", "WBGene00022453", "Q95XH1", "WBGene00022077", "G5EBK2", "WBGene00014084", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q19767", "WBGene00004898", "Q94057", "WBGene00044062", "Q9XZI6", "WBGene00006751", "Q9N532", "WBGene00003238", "G5EDV1", "WBGene00003006", "P34889", "WBGene00000858", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "Q9U7D5", "WBGene00001519", "P51485", "WBGene00000195", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "P90761", "WBGene00006777", "Q18453", "WBGene00004682", "Q9BI71", "WBGene00001329", "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "P29355", "WBGene00004774", "Q17796", "WBGene00004101", "O01498", "WBGene00004109", "Q21496", "WBGene00020010", "Q21948", "WBGene00020010", "A0A486WXX8", "WBGene00000894", "Q95QV2", "WBGene00000477", "Q19625", "WBGene00003412", "P34711", "WBGene00006756", "Q9XTT3", "WBGene00013039", "A0A0K3AS36", "Y116A8C.36d", "Q6AHQ8", "WBGene00018467", "Q8I4E2", "WBGene00003086", "P39055", "WBGene00001130", "species_29438", "Q02328", "WBGene00022717", "P0DM42", "WBGene00000065", "P10984", "WBGene00000064", "P10986", "WBGene00000066", "P0DM41", "WBGene00000063", "species_29358", "P58798", "WBGene00000204", "A0A3P6PCS5", "WBGene00000201", "Q9N4I0", "WBGene00000199", "Q8WTM6", "WBGene00021170", "P53489", "WBGene00000200", "Q9XWV3", "WBGene00000203", "O61861", "WBGene00000205", "P91167", "WBGene00016729", "Q19253", "WBGene00017298", "Q9XUS7", "WBGene00010663", "B1V8A0", "WBGene00006791", "Q21004", "WBGene00010272", "Q9BIF4", "WBGene00001224", "G5ECQ3", "WBGene00004762", "Q20483", "WBGene00018516", "species_179856", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "Q9TXS0", "WBGene00018974", "Q9N489", "WBGene00022453", "Q95XH1", "WBGene00022077", "G5EBK2", "WBGene00014084", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q19767", "WBGene00004898", "Q94057", "WBGene00044062", "Q9XZI6", "WBGene00006751", "Q9N532", "WBGene00003238", "G5EDV1", "WBGene00003006", "P34889", "WBGene00000858", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "Q9U7D5", "WBGene00001519", "P51485", "WBGene00000195", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "P90761", "WBGene00006777", "Q18453", "WBGene00004682", "Q9BI71", "WBGene00001329", "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "P29355", "WBGene00004774", "Q17796", "WBGene00004101", "O01498", "WBGene00004109", "Q21496", "WBGene00020010", "Q21948", "WBGene00020010", "A0A486WXX8", "WBGene00000894", "Q95QV2", "WBGene00000477", "Q19625", "WBGene00003412", "P34711", "WBGene00006756", "Q9XTT3", "WBGene00013039", "A0A0K3AS36", "Y116A8C.36d", "Q6AHQ8", "WBGene00018467", "Q8I4E2", "WBGene00003086", "P39055", "WBGene00001130", "species_29438", "O17590", "WBGene00007620", "G5ECL2", "WBGene00006763" ] }, "reaction_10566462": { "compartment": "compartment_876", "id": "reaction_10566462", "reactome": "R-CEL-8867754", "name": "F- and N- BAR domain proteins bind the clathrin-coated pit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10566428", "species_10566426", "species_10566456", "species_10566409", "species_10566437", "species_10512243", "species_10566403", "species_10566448" ], "products": [ "species_10565743", "species_10566460", "species_10537176" ], "modifiers": [ [ "species_202247", "catalyst" ] ], "additional_components": [ "WBGene00003086", "Q6AHQ8", "WBGene00018467", "Q19253", "WBGene00017298", "Q9XUS7", "WBGene00010663", "Q21004", "WBGene00010272", "Q19253", "WBGene00017298", "B1V8A0", "WBGene00006791", "G5ECQ3", "WBGene00004762", "Q20483", "WBGene00018516", "Q9BIF4", "WBGene00001224", "species_179856", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "Q9TXS0", "WBGene00018974", "Q9N489", "WBGene00022453", "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "Q19123", "WBGene00000157", "P35603", "WBGene00001082", "A0A0K3AS36", "Y116A8C.36d", "Q95XH1", "WBGene00022077", "G5EBK2", "WBGene00014084", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q19767", "WBGene00004898", "Q94057", "WBGene00044062", "Q9XZI6", "WBGene00006751", "Q9N532", "WBGene00003238", "G5EDV1", "WBGene00003006", "P34889", "WBGene00000858", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "Q9U7D5", "WBGene00001519", "P51485", "WBGene00000195", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "P90761", "WBGene00006777", "Q18453", "WBGene00004682", "Q9BI71", "WBGene00001329", "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "B1V8A0", "WBGene00006791", "P29355", "WBGene00004774", "Q17796", "WBGene00004101", "O01498", "WBGene00004109", "Q21496", "WBGene00020010", "Q21948", "WBGene00020010", "A0A486WXX8", "WBGene00000894", "Q95QV2", "WBGene00000477", "Q19625", "WBGene00003412", "P34711", "WBGene00006756", "Q9XTT3", "WBGene00013039", "G5EDY0", "WBGene00009552", "Q19253", "WBGene00017298", "Q9XUS7", "WBGene00010663", "Q9TXS0", "WBGene00018974", "Q19253", "WBGene00017298", "Q9XUS7", "WBGene00010663", "B1V8A0", "WBGene00006791", "Q21004", "WBGene00010272", "Q9BIF4", "WBGene00001224", "G5ECQ3", "WBGene00004762", "Q20483", "WBGene00018516", "species_179856", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "Q9TXS0", "WBGene00018974", "Q9N489", "WBGene00022453", "Q95XH1", "WBGene00022077", "G5EBK2", "WBGene00014084", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q19767", "WBGene00004898", "Q94057", "WBGene00044062", "Q9XZI6", "WBGene00006751", "Q9N532", "WBGene00003238", "G5EDV1", "WBGene00003006", "P34889", "WBGene00000858", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "Q9U7D5", "WBGene00001519", "P51485", "WBGene00000195", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "P90761", "WBGene00006777", "Q18453", "WBGene00004682", "Q9BI71", "WBGene00001329", "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "P29355", "WBGene00004774", "Q17796", "WBGene00004101", "O01498", "WBGene00004109", "Q21496", "WBGene00020010", "Q21948", "WBGene00020010", "A0A486WXX8", "WBGene00000894", "Q95QV2", "WBGene00000477", "Q19625", "WBGene00003412", "P34711", "WBGene00006756", "Q9XTT3", "WBGene00013039", "A0A0K3AS36", "Y116A8C.36d", "Q6AHQ8", "WBGene00018467", "Q8I4E2", "WBGene00003086", "WBGene00009552" ] }, "reaction_10552405": { "compartment": "compartment_70101", "id": "reaction_10552405", "reactome": "R-CEL-5577213", "name": "LTCC multimer transports Ca2+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74112" ], "products": [ "species_74016" ], "modifiers": [ [ "species_10552402", "catalyst" ] ], "additional_components": [ "G5EG74", "WBGene00007041", "P34374", "WBGene00006772", "G5EBI8", "WBGene00017400", "G5EDT2", "WBGene00007670", "Q8MQA1", "WBGene00001187", "A0A078BQJ0", "WBGene00021125", "O01661", "WBGene00000368" ] }, "reaction_10552761": { "compartment": "compartment_70101", "id": "reaction_10552761", "reactome": "R-CEL-5617179", "name": "PRKACA phosphorylates TNNI3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10552741" ], "products": [ "species_29370", "species_10552759" ], "modifiers": [ [ "species_10508954", "catalyst" ] ], "additional_components": [ "Q9XUN9", "WBGene00006585", "O44572", "WBGene00006586", "Q20334", "WBGene00006584", "Q9GYF1", "WBGene00006764", "Q9GYF1", "WBGene00006764", "Q9XUN9", "WBGene00006585", "O44572", "WBGene00006586", "Q20334", "WBGene00006584", "WBGene00002189" ] }, "reaction_10524944": { "compartment": "compartment_70101", "id": "reaction_10524944", "reactome": "R-CEL-445700", "name": "Myosin Binds ATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10524942", "species_113592" ], "products": [ "species_10524933" ], "modifiers": [], "additional_components": [ "Q20641", "WBGene00003776", "Q8I7M7", "WBGene00006582", "O01479", "WBGene00006823", "P0DM41", "WBGene00000063", "P0DM42", "WBGene00000065", "P10984", "WBGene00000064", "P10986", "WBGene00000066", "species_74016", "Q22866", "WBGene00002978", "P19625", "WBGene00003369", "P19626", "WBGene00003370", "Q09510", "WBGene00003372", "Q20238", "WBGene00009585", "Q21201", "WBGene00010554", "Q69Z12", "WBGene00023451", "Q9XVI9", "WBGene00011734", "P53014", "WBGene00003371", "G5EGK1", "WBGene00006771", "P19826", "WBGene00000942", "G5EC32", "WBGene00012891", "P34446", "WBGene00003929", "Q20641", "WBGene00003776", "species_29358", "P19625", "WBGene00003369", "P19626", "WBGene00003370", "Q09510", "WBGene00003372", "Q20238", "WBGene00009585", "Q21201", "WBGene00010554", "Q69Z12", "WBGene00023451", "Q9XVI9", "WBGene00011734", "P53014", "WBGene00003371", "Q8I7M7", "WBGene00006582", "O01479", "WBGene00006823", "P0DM41", "WBGene00000063", "P0DM42", "WBGene00000065", "P10984", "WBGene00000064", "P10986", "WBGene00000066", "species_74016", "Q22866", "WBGene00002978", "G5EGK1", "WBGene00006771", "P19826", "WBGene00000942", "G5EC32", "WBGene00012891", "P34446", "WBGene00003929" ] }, "reaction_10524948": { "compartment": "compartment_70101", "id": "reaction_10524948", "reactome": "R-CEL-445704", "name": "Calcium Binds Caldesmon", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10524946", "species_74016" ], "products": [ "species_10524942" ], "modifiers": [], "additional_components": [ "Q20641", "WBGene00003776", "Q8I7M7", "WBGene00006582", "O01479", "WBGene00006823", "P0DM41", "WBGene00000063", "P0DM42", "WBGene00000065", "P10984", "WBGene00000064", "P10986", "WBGene00000066", "Q22866", "WBGene00002978", "P19625", "WBGene00003369", "P19626", "WBGene00003370", "Q09510", "WBGene00003372", "Q20238", "WBGene00009585", "Q21201", "WBGene00010554", "Q69Z12", "WBGene00023451", "Q9XVI9", "WBGene00011734", "P53014", "WBGene00003371", "G5EGK1", "WBGene00006771", "P19826", "WBGene00000942", "G5EC32", "WBGene00012891", "P34446", "WBGene00003929", "Q20641", "WBGene00003776", "Q8I7M7", "WBGene00006582", "O01479", "WBGene00006823", "P0DM41", "WBGene00000063", "P0DM42", "WBGene00000065", "P10984", "WBGene00000064", "P10986", "WBGene00000066", "species_74016", "Q22866", "WBGene00002978", "P19625", "WBGene00003369", "P19626", "WBGene00003370", "Q09510", "WBGene00003372", "Q20238", "WBGene00009585", "Q21201", "WBGene00010554", "Q69Z12", "WBGene00023451", "Q9XVI9", "WBGene00011734", "P53014", "WBGene00003371", "G5EGK1", "WBGene00006771", "P19826", "WBGene00000942", "G5EC32", "WBGene00012891", "P34446", "WBGene00003929" ] }, "reaction_10524950": { "compartment": "compartment_70101", "id": "reaction_10524950", "reactome": "R-CEL-445705", "name": "Release Of ADP From Myosin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10524937" ], "products": [ "species_10524942", "species_29370" ], "modifiers": [], "additional_components": [ "Q8I7M7", "WBGene00006582", "O01479", "WBGene00006823", "P0DM41", "WBGene00000063", "P0DM42", "WBGene00000065", "P10984", "WBGene00000064", "P10986", "WBGene00000066", "species_74016", "Q20641", "WBGene00003776", "species_113582", "P19625", "WBGene00003369", "P19626", "WBGene00003370", "Q09510", "WBGene00003372", "Q20238", "WBGene00009585", "Q21201", "WBGene00010554", "Q69Z12", "WBGene00023451", "Q9XVI9", "WBGene00011734", "P53014", "WBGene00003371", "Q22866", "WBGene00002978", "G5EGK1", "WBGene00006771", "P19826", "WBGene00000942", "G5EC32", "WBGene00012891", "P34446", "WBGene00003929", "Q20641", "WBGene00003776", "Q8I7M7", "WBGene00006582", "O01479", "WBGene00006823", "P0DM41", "WBGene00000063", "P0DM42", "WBGene00000065", "P10984", "WBGene00000064", "P10986", "WBGene00000066", "species_74016", "Q22866", "WBGene00002978", "P19625", "WBGene00003369", "P19626", "WBGene00003370", "Q09510", "WBGene00003372", "Q20238", "WBGene00009585", "Q21201", "WBGene00010554", "Q69Z12", "WBGene00023451", "Q9XVI9", "WBGene00011734", "P53014", "WBGene00003371", "G5EGK1", "WBGene00006771", "P19826", "WBGene00000942", "G5EC32", "WBGene00012891", "P34446", "WBGene00003929" ] }, "reaction_10524940": { "compartment": "compartment_70101", "id": "reaction_10524940", "reactome": "R-CEL-445699", "name": "ATP Hydrolysis By Myosin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10524933" ], "products": [ "species_29372", "species_10524937" ], "modifiers": [ [ "species_10524866", "catalyst" ] ], "additional_components": [ "Q20641", "WBGene00003776", "species_29358", "P19625", "WBGene00003369", "P19626", "WBGene00003370", "Q09510", "WBGene00003372", "Q20238", "WBGene00009585", "Q21201", "WBGene00010554", "Q69Z12", "WBGene00023451", "Q9XVI9", "WBGene00011734", "P53014", "WBGene00003371", "Q8I7M7", "WBGene00006582", "O01479", "WBGene00006823", "P0DM41", "WBGene00000063", "P0DM42", "WBGene00000065", "P10984", "WBGene00000064", "P10986", "WBGene00000066", "species_74016", "Q22866", "WBGene00002978", "G5EGK1", "WBGene00006771", "P19826", "WBGene00000942", "G5EC32", "WBGene00012891", "P34446", "WBGene00003929", "Q8I7M7", "WBGene00006582", "O01479", "WBGene00006823", "P0DM41", "WBGene00000063", "P0DM42", "WBGene00000065", "P10984", "WBGene00000064", "P10986", "WBGene00000066", "species_74016", "Q20641", "WBGene00003776", "species_113582", "P19625", "WBGene00003369", "P19626", "WBGene00003370", "Q09510", "WBGene00003372", "Q20238", "WBGene00009585", "Q21201", "WBGene00010554", "Q69Z12", "WBGene00023451", "Q9XVI9", "WBGene00011734", "P53014", "WBGene00003371", "Q22866", "WBGene00002978", "G5EGK1", "WBGene00006771", "P19826", "WBGene00000942", "G5EC32", "WBGene00012891", "P34446", "WBGene00003929", "Q20641", "WBGene00003776", "species_29358", "P19625", "WBGene00003369", "P19626", "WBGene00003370", "Q09510", "WBGene00003372", "Q20238", "WBGene00009585", "Q21201", "WBGene00010554", "Q69Z12", "WBGene00023451", "Q9XVI9", "WBGene00011734", "P53014", "WBGene00003371" ] }, "reaction_10551263": { "compartment": "compartment_437051", "id": "reaction_10551263", "reactome": "R-CEL-5263633", "name": "DYSF, CAV3 and TRIM72 bind", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10551259", "species_10551257", "species_10551252" ], "products": [ "species_10551261" ], "modifiers": [ [ "species_74016", "catalyst" ] ], "additional_components": [ "WBGene00021640", "WBGene00001414", "WBGene00000302", "Q18879", "WBGene00000302", "Q17388", "WBGene00001414", "Q9N3T6", "WBGene00021640" ] }, "reaction_10517408": { "compartment": "compartment_984", "id": "reaction_10517408", "reactome": "R-CEL-216058", "name": "Integrin alpha7beta1 binds Laminin-211, 221, 411, 512, 521", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10517404", "species_10517402" ], "products": [ "species_10517406" ], "modifiers": [], "additional_components": [ "Q18823", "WBGene00016913", "O44565", "WBGene00002247", "G5ECE3", "WBGene00002248", "Q21313", "WBGene00001328", "Q27874", "WBGene00003930", "Q03600", "WBGene00002081", "Q27874", "WBGene00003930", "Q03600", "WBGene00002081", "Q18823", "WBGene00016913", "O44565", "WBGene00002247", "G5ECE3", "WBGene00002248", "Q21313", "WBGene00001328" ] }, "reaction_10517382": { "compartment": "compartment_984", "id": "reaction_10517382", "reactome": "R-CEL-216048", "name": "Integrins alpha3beta1, alpha6beta4 bind laminin-332, 511, 521, (211, 221)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10517378", "species_10517313" ], "products": [ "species_10517380" ], "modifiers": [], "additional_components": [ "Q18823", "WBGene00016913", "Q21313", "WBGene00001328", "O44565", "WBGene00002247", "Q19981", "WBGene00006432", "G5EG68", "WBGene00018304", "Q06561", "WBGene00006787", "G5ECE3", "WBGene00002248", "Q03600", "WBGene00002081", "Q27874", "WBGene00003930", "Q03600", "WBGene00002081", "Q27874", "WBGene00003930", "Q18823", "WBGene00016913", "Q21313", "WBGene00001328", "O44565", "WBGene00002247", "Q19981", "WBGene00006432", "G5EG68", "WBGene00018304", "Q06561", "WBGene00006787", "G5ECE3", "WBGene00002248" ] }, "reaction_10548376": { "compartment": "compartment_876", "id": "reaction_10548376", "reactome": "R-CEL-3907292", "name": "Integrin alpha6beta1 binds laminin-322, 512, 521, 211, 221, 411", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10548372", "species_10548370" ], "products": [ "species_10548374" ], "modifiers": [], "additional_components": [ "Q18823", "WBGene00016913", "O44565", "WBGene00002247", "G5ECE3", "WBGene00002248", "Q21313", "WBGene00001328", "Q19981", "WBGene00006432", "G5EG68", "WBGene00018304", "Q06561", "WBGene00006787", "Q27874", "WBGene00003930", "Q03600", "WBGene00002081", "Q27874", "WBGene00003930", "Q03600", "WBGene00002081", "Q18823", "WBGene00016913", "O44565", "WBGene00002247", "G5ECE3", "WBGene00002248", "Q21313", "WBGene00001328", "Q19981", "WBGene00006432", "G5EG68", "WBGene00018304", "Q06561", "WBGene00006787" ] }, "reaction_10517896": { "compartment": "compartment_984", "id": "reaction_10517896", "reactome": "R-CEL-349626", "name": "Integrin alpha2beta1 binds laminin-332", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10517354", "species_10517892" ], "products": [ "species_10517894" ], "modifiers": [], "additional_components": [ "O44565", "WBGene00002247", "Q18823", "WBGene00016913", "Q19981", "WBGene00006432", "G5EG68", "WBGene00018304", "Q06561", "WBGene00006787", "G5ECE3", "WBGene00002248", "Q21313", "WBGene00001328", "P34446", "WBGene00003929", "Q27874", "WBGene00003930", "P34446", "WBGene00003929", "Q27874", "WBGene00003930", "O44565", "WBGene00002247", "Q18823", "WBGene00016913", "Q19981", "WBGene00006432", "G5EG68", "WBGene00018304", "Q06561", "WBGene00006787", "G5ECE3", "WBGene00002248", "Q21313", "WBGene00001328" ] }, "reaction_10548927": { "compartment": "compartment_984", "id": "reaction_10548927", "reactome": "R-CEL-4084507", "name": "Laminin-111 binds endostatin dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10548923", "species_10544249" ], "products": [ "species_10548925" ], "modifiers": [], "additional_components": [ "Q19368", "WBGene00000702", "Q18823", "WBGene00016913", "G5ECE3", "WBGene00002248", "Q21313", "WBGene00001328", "O44565", "WBGene00002247", "Q18823", "WBGene00016913", "G5ECE3", "WBGene00002248", "Q21313", "WBGene00001328", "O44565", "WBGene00002247", "Q19368", "WBGene00000702" ] }, "reaction_10572433": { "compartment": "compartment_17938", "id": "reaction_10572433", "reactome": "R-CEL-9639286", "name": "RRAGC,D exchanges GTP for GDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29420", "species_10572426" ], "products": [ "species_10572430", "species_29438" ], "modifiers": [ [ "species_10572426", "catalyst" ] ], "additional_components": [ "species_29420", "Q22743", "WBGene00006414", "G5EGB3", "WBGene00012497", "species_29438", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "Q9XXU9", "WBGene00006920", "Q22494", "WBGene00020507", "Q23680", "WBGene00006918", "P34462", "WBGene00010130", "Q9XW92", "WBGene00013025", "Q19626", "WBGene00006921", "Q9N5A0", "WBGene00004959", "Q95X44", "WBGene00006917", "P91303", "WBGene00006919", "C0HLB3", "WBGene00006911", "C0HLB4", "WBGene00006912", "Q95YD5", "WBGene00016258", "G5EEK9", "WBGene00006914", "G5EGP4", "WBGene00006915", "P30628", "WBGene00006768", "B2MZD0", "WBGene00006916", "Q20591", "WBGene00009882", "G5EDB8", "WBGene00006913", "species_29420", "Q22743", "WBGene00006414", "G5EGB3", "WBGene00012497", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "Q9XXU9", "WBGene00006920", "Q22494", "WBGene00020507", "Q23680", "WBGene00006918", "P34462", "WBGene00010130", "Q9XW92", "WBGene00013025", "Q19626", "WBGene00006921", "Q9N5A0", "WBGene00004959", "Q95X44", "WBGene00006917", "P91303", "WBGene00006919", "C0HLB3", "WBGene00006911", "C0HLB4", "WBGene00006912", "Q95YD5", "WBGene00016258", "G5EEK9", "WBGene00006914", "G5EGP4", "WBGene00006915", "P30628", "WBGene00006768", "B2MZD0", "WBGene00006916", "Q20591", "WBGene00009882", "G5EDB8", "WBGene00006913", "species_29420", "Q22743", "WBGene00006414", "G5EGB3", "WBGene00012497", "species_29438", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "Q9XXU9", "WBGene00006920", "Q22494", "WBGene00020507", "Q23680", "WBGene00006918", "P34462", "WBGene00010130", "Q9XW92", "WBGene00013025", "Q19626", "WBGene00006921", "Q9N5A0", "WBGene00004959", "Q95X44", "WBGene00006917", "P91303", "WBGene00006919", "C0HLB3", "WBGene00006911", "C0HLB4", "WBGene00006912", "Q95YD5", "WBGene00016258", "G5EEK9", "WBGene00006914", "G5EGP4", "WBGene00006915", "P30628", "WBGene00006768", "B2MZD0", "WBGene00006916", "Q20591", "WBGene00009882", "G5EDB8", "WBGene00006913" ] }, "reaction_10572545": { "compartment": "compartment_17938", "id": "reaction_10572545", "reactome": "R-CEL-9645608", "name": "v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10510526", "species_10572439" ], "products": [ "species_10572450" ], "modifiers": [], "additional_components": [ "P91040", "WBGene00015697", "Q95Q95", "WBGene00002583", "Q68TI8", "WBGene00000911", "species_29420", "G5EGB3", "WBGene00012497", "Q22743", "WBGene00006414", "species_29438", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "Q9XXU9", "WBGene00006920", "Q22494", "WBGene00020507", "Q23680", "WBGene00006918", "P34462", "WBGene00010130", "Q9XW92", "WBGene00013025", "Q19626", "WBGene00006921", "Q9N5A0", "WBGene00004959", "Q95X44", "WBGene00006917", "P91303", "WBGene00006919", "C0HLB3", "WBGene00006911", "C0HLB4", "WBGene00006912", "Q95YD5", "WBGene00016258", "G5EEK9", "WBGene00006914", "G5EGP4", "WBGene00006915", "P30628", "WBGene00006768", "B2MZD0", "WBGene00006916", "Q20591", "WBGene00009882", "G5EDB8", "WBGene00006913", "species_29420", "G5EGB3", "WBGene00012497", "Q22743", "WBGene00006414", "species_29438", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "Q9XXU9", "WBGene00006920", "Q22494", "WBGene00020507", "Q23680", "WBGene00006918", "P34462", "WBGene00010130", "Q9XW92", "WBGene00013025", "Q19626", "WBGene00006921", "Q9N5A0", "WBGene00004959", "Q95X44", "WBGene00006917", "P91303", "WBGene00006919", "C0HLB3", "WBGene00006911", "C0HLB4", "WBGene00006912", "Q95YD5", "WBGene00016258", "G5EEK9", "WBGene00006914", "G5EGP4", "WBGene00006915", "P30628", "WBGene00006768", "B2MZD0", "WBGene00006916", "Q20591", "WBGene00009882", "G5EDB8", "WBGene00006913", "P91040", "WBGene00015697", "Q95Q95", "WBGene00002583", "Q68TI8", "WBGene00000911" ] }, "reaction_10572448": { "compartment": "compartment_17938", "id": "reaction_10572448", "reactome": "R-CEL-9640175", "name": "v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10572430", "species_10572435" ], "products": [ "species_10572437" ], "modifiers": [], "additional_components": [ "species_29420", "Q22743", "WBGene00006414", "G5EGB3", "WBGene00012497", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "Q9XXU9", "WBGene00006920", "Q22494", "WBGene00020507", "Q23680", "WBGene00006918", "P34462", "WBGene00010130", "Q9XW92", "WBGene00013025", "Q19626", "WBGene00006921", "Q9N5A0", "WBGene00004959", "Q95X44", "WBGene00006917", "P91303", "WBGene00006919", "C0HLB3", "WBGene00006911", "C0HLB4", "WBGene00006912", "Q95YD5", "WBGene00016258", "G5EEK9", "WBGene00006914", "G5EGP4", "WBGene00006915", "P30628", "WBGene00006768", "B2MZD0", "WBGene00006916", "Q20591", "WBGene00009882", "G5EDB8", "WBGene00006913", "Q19425", "WBGene00008774", "species_29468", "Q19425", "WBGene00008774", "species_29468", "species_29420", "Q22743", "WBGene00006414", "G5EGB3", "WBGene00012497", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "Q9XXU9", "WBGene00006920", "Q22494", "WBGene00020507", "Q23680", "WBGene00006918", "P34462", "WBGene00010130", "Q9XW92", "WBGene00013025", "Q19626", "WBGene00006921", "Q9N5A0", "WBGene00004959", "Q95X44", "WBGene00006917", "P91303", "WBGene00006919", "C0HLB3", "WBGene00006911", "C0HLB4", "WBGene00006912", "Q95YD5", "WBGene00016258", "G5EEK9", "WBGene00006914", "G5EGP4", "WBGene00006915", "P30628", "WBGene00006768", "B2MZD0", "WBGene00006916", "Q20591", "WBGene00009882", "G5EDB8", "WBGene00006913" ] }, "reaction_10572553": { "compartment": "compartment_17938", "id": "reaction_10572553", "reactome": "R-CEL-9646468", "name": "mTORC1 binds RHEB:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10510507", "species_10572450" ], "products": [ "species_10572452" ], "modifiers": [], "additional_components": [ "P34443", "WBGene00010038", "species_29438", "species_29420", "G5EGB3", "WBGene00012497", "Q22743", "WBGene00006414", "species_29438", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "Q9XXU9", "WBGene00006920", "Q22494", "WBGene00020507", "Q23680", "WBGene00006918", "P34462", "WBGene00010130", "Q9XW92", "WBGene00013025", "Q19626", "WBGene00006921", "Q9N5A0", "WBGene00004959", "Q95X44", "WBGene00006917", "P91303", "WBGene00006919", "C0HLB3", "WBGene00006911", "C0HLB4", "WBGene00006912", "Q95YD5", "WBGene00016258", "G5EEK9", "WBGene00006914", "G5EGP4", "WBGene00006915", "P30628", "WBGene00006768", "B2MZD0", "WBGene00006916", "Q20591", "WBGene00009882", "G5EDB8", "WBGene00006913", "P91040", "WBGene00015697", "Q95Q95", "WBGene00002583", "Q68TI8", "WBGene00000911", "species_29420", "G5EGB3", "WBGene00012497", "Q22743", "WBGene00006414", "species_29438", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "Q9XXU9", "WBGene00006920", "Q22494", "WBGene00020507", "Q23680", "WBGene00006918", "P34462", "WBGene00010130", "Q9XW92", "WBGene00013025", "Q19626", "WBGene00006921", "Q9N5A0", "WBGene00004959", "Q95X44", "WBGene00006917", "P91303", "WBGene00006919", "C0HLB3", "WBGene00006911", "C0HLB4", "WBGene00006912", "Q95YD5", "WBGene00016258", "G5EEK9", "WBGene00006914", "G5EGP4", "WBGene00006915", "P30628", "WBGene00006768", "B2MZD0", "WBGene00006916", "Q20591", "WBGene00009882", "G5EDB8", "WBGene00006913", "P91040", "WBGene00015697", "Q95Q95", "WBGene00002583", "Q68TI8", "WBGene00000911", "P34443", "WBGene00010038" ] }, "reaction_10572457": { "compartment": "compartment_17938", "id": "reaction_10572457", "reactome": "R-CEL-9640195", "name": "RRAGA,B hydrolyzes GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10572452" ], "products": [ "species_29372", "species_10572454" ], "modifiers": [ [ "species_10572452", "catalyst" ] ], "additional_components": [ "species_29420", "G5EGB3", "WBGene00012497", "Q22743", "WBGene00006414", "species_29438", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "Q9XXU9", "WBGene00006920", "Q22494", "WBGene00020507", "Q23680", "WBGene00006918", "P34462", "WBGene00010130", "Q9XW92", "WBGene00013025", "Q19626", "WBGene00006921", "Q9N5A0", "WBGene00004959", "Q95X44", "WBGene00006917", "P91303", "WBGene00006919", "C0HLB3", "WBGene00006911", "C0HLB4", "WBGene00006912", "Q95YD5", "WBGene00016258", "G5EEK9", "WBGene00006914", "G5EGP4", "WBGene00006915", "P30628", "WBGene00006768", "B2MZD0", "WBGene00006916", "Q20591", "WBGene00009882", "G5EDB8", "WBGene00006913", "P91040", "WBGene00015697", "Q95Q95", "WBGene00002583", "Q68TI8", "WBGene00000911", "P34443", "WBGene00010038", "P34443", "WBGene00010038", "species_29438", "P91040", "WBGene00015697", "Q95Q95", "WBGene00002583", "Q68TI8", "WBGene00000911", "species_29420", "Q22743", "WBGene00006414", "G5EGB3", "WBGene00012497", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "Q9XXU9", "WBGene00006920", "Q22494", "WBGene00020507", "Q23680", "WBGene00006918", "P34462", "WBGene00010130", "Q9XW92", "WBGene00013025", "Q19626", "WBGene00006921", "Q9N5A0", "WBGene00004959", "Q95X44", "WBGene00006917", "P91303", "WBGene00006919", "C0HLB3", "WBGene00006911", "C0HLB4", "WBGene00006912", "Q95YD5", "WBGene00016258", "G5EEK9", "WBGene00006914", "G5EGP4", "WBGene00006915", "P30628", "WBGene00006768", "B2MZD0", "WBGene00006916", "Q20591", "WBGene00009882", "G5EDB8", "WBGene00006913", "species_29420", "G5EGB3", "WBGene00012497", "Q22743", "WBGene00006414", "species_29438", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "Q9XXU9", "WBGene00006920", "Q22494", "WBGene00020507", "Q23680", "WBGene00006918", "P34462", "WBGene00010130", "Q9XW92", "WBGene00013025", "Q19626", "WBGene00006921", "Q9N5A0", "WBGene00004959", "Q95X44", "WBGene00006917", "P91303", "WBGene00006919", "C0HLB3", "WBGene00006911", "C0HLB4", "WBGene00006912", "Q95YD5", "WBGene00016258", "G5EEK9", "WBGene00006914", "G5EGP4", "WBGene00006915", "P30628", "WBGene00006768", "B2MZD0", "WBGene00006916", "Q20591", "WBGene00009882", "G5EDB8", "WBGene00006913", "P91040", "WBGene00015697", "Q95Q95", "WBGene00002583", "Q68TI8", "WBGene00000911", "P34443", "WBGene00010038" ] }, "reaction_10572444": { "compartment": "compartment_17938", "id": "reaction_10572444", "reactome": "R-CEL-9640167", "name": "RRAGA,B exchanges GDP for GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10572437" ], "products": [ "species_29420", "species_10572441" ], "modifiers": [ [ "species_10572437", "catalyst" ] ], "additional_components": [ "Q19425", "WBGene00008774", "species_29468", "species_29420", "Q22743", "WBGene00006414", "G5EGB3", "WBGene00012497", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "Q9XXU9", "WBGene00006920", "Q22494", "WBGene00020507", "Q23680", "WBGene00006918", "P34462", "WBGene00010130", "Q9XW92", "WBGene00013025", "Q19626", "WBGene00006921", "Q9N5A0", "WBGene00004959", "Q95X44", "WBGene00006917", "P91303", "WBGene00006919", "C0HLB3", "WBGene00006911", "C0HLB4", "WBGene00006912", "Q95YD5", "WBGene00016258", "G5EEK9", "WBGene00006914", "G5EGP4", "WBGene00006915", "P30628", "WBGene00006768", "B2MZD0", "WBGene00006916", "Q20591", "WBGene00009882", "G5EDB8", "WBGene00006913", "Q19425", "WBGene00008774", "species_29468", "species_29420", "G5EGB3", "WBGene00012497", "Q22743", "WBGene00006414", "species_29438", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "Q9XXU9", "WBGene00006920", "Q22494", "WBGene00020507", "Q23680", "WBGene00006918", "P34462", "WBGene00010130", "Q9XW92", "WBGene00013025", "Q19626", "WBGene00006921", "Q9N5A0", "WBGene00004959", "Q95X44", "WBGene00006917", "P91303", "WBGene00006919", "C0HLB3", "WBGene00006911", "C0HLB4", "WBGene00006912", "Q95YD5", "WBGene00016258", "G5EEK9", "WBGene00006914", "G5EGP4", "WBGene00006915", "P30628", "WBGene00006768", "B2MZD0", "WBGene00006916", "Q20591", "WBGene00009882", "G5EDB8", "WBGene00006913", "Q19425", "WBGene00008774", "species_29468", "species_29420", "Q22743", "WBGene00006414", "G5EGB3", "WBGene00012497", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "Q9XXU9", "WBGene00006920", "Q22494", "WBGene00020507", "Q23680", "WBGene00006918", "P34462", "WBGene00010130", "Q9XW92", "WBGene00013025", "Q19626", "WBGene00006921", "Q9N5A0", "WBGene00004959", "Q95X44", "WBGene00006917", "P91303", "WBGene00006919", "C0HLB3", "WBGene00006911", "C0HLB4", "WBGene00006912", "Q95YD5", "WBGene00016258", "G5EEK9", "WBGene00006914", "G5EGP4", "WBGene00006915", "P30628", "WBGene00006768", "B2MZD0", "WBGene00006916", "Q20591", "WBGene00009882", "G5EDB8", "WBGene00006913" ] }, "reaction_10572542": { "compartment": "compartment_17938", "id": "reaction_10572542", "reactome": "R-CEL-9645598", "name": "RRAGC,D hydrolyzes GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10572426" ], "products": [ "species_10572430", "species_29372" ], "modifiers": [ [ "species_10572426", "catalyst" ], [ "species_10572540", "catalyst" ] ], "additional_components": [ "species_29420", "Q22743", "WBGene00006414", "G5EGB3", "WBGene00012497", "species_29438", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "Q9XXU9", "WBGene00006920", "Q22494", "WBGene00020507", "Q23680", "WBGene00006918", "P34462", "WBGene00010130", "Q9XW92", "WBGene00013025", "Q19626", "WBGene00006921", "Q9N5A0", "WBGene00004959", "Q95X44", "WBGene00006917", "P91303", "WBGene00006919", "C0HLB3", "WBGene00006911", "C0HLB4", "WBGene00006912", "Q95YD5", "WBGene00016258", "G5EEK9", "WBGene00006914", "G5EGP4", "WBGene00006915", "P30628", "WBGene00006768", "B2MZD0", "WBGene00006916", "Q20591", "WBGene00009882", "G5EDB8", "WBGene00006913", "species_29420", "Q22743", "WBGene00006414", "G5EGB3", "WBGene00012497", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "Q9XXU9", "WBGene00006920", "Q22494", "WBGene00020507", "Q23680", "WBGene00006918", "P34462", "WBGene00010130", "Q9XW92", "WBGene00013025", "Q19626", "WBGene00006921", "Q9N5A0", "WBGene00004959", "Q95X44", "WBGene00006917", "P91303", "WBGene00006919", "C0HLB3", "WBGene00006911", "C0HLB4", "WBGene00006912", "Q95YD5", "WBGene00016258", "G5EEK9", "WBGene00006914", "G5EGP4", "WBGene00006915", "P30628", "WBGene00006768", "B2MZD0", "WBGene00006916", "Q20591", "WBGene00009882", "G5EDB8", "WBGene00006913", "species_29420", "Q22743", "WBGene00006414", "G5EGB3", "WBGene00012497", "species_29438", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "Q9XXU9", "WBGene00006920", "Q22494", "WBGene00020507", "Q23680", "WBGene00006918", "P34462", "WBGene00010130", "Q9XW92", "WBGene00013025", "Q19626", "WBGene00006921", "Q9N5A0", "WBGene00004959", "Q95X44", "WBGene00006917", "P91303", "WBGene00006919", "C0HLB3", "WBGene00006911", "C0HLB4", "WBGene00006912", "Q95YD5", "WBGene00016258", "G5EEK9", "WBGene00006914", "G5EGP4", "WBGene00006915", "P30628", "WBGene00006768", "B2MZD0", "WBGene00006916", "Q20591", "WBGene00009882", "G5EDB8", "WBGene00006913", "S6FMZ4", "WBGene00017699", "H2L0I8", "WBGene00020208" ] }, "reaction_10572446": { "compartment": "compartment_17938", "id": "reaction_10572446", "reactome": "R-CEL-9640168", "name": "v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10572441" ], "products": [ "species_10572439", "species_10572435" ], "modifiers": [], "additional_components": [ "Q19425", "WBGene00008774", "species_29468", "species_29420", "G5EGB3", "WBGene00012497", "Q22743", "WBGene00006414", "species_29438", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "Q9XXU9", "WBGene00006920", "Q22494", "WBGene00020507", "Q23680", "WBGene00006918", "P34462", "WBGene00010130", "Q9XW92", "WBGene00013025", "Q19626", "WBGene00006921", "Q9N5A0", "WBGene00004959", "Q95X44", "WBGene00006917", "P91303", "WBGene00006919", "C0HLB3", "WBGene00006911", "C0HLB4", "WBGene00006912", "Q95YD5", "WBGene00016258", "G5EEK9", "WBGene00006914", "G5EGP4", "WBGene00006915", "P30628", "WBGene00006768", "B2MZD0", "WBGene00006916", "Q20591", "WBGene00009882", "G5EDB8", "WBGene00006913", "species_29420", "G5EGB3", "WBGene00012497", "Q22743", "WBGene00006414", "species_29438", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "Q9XXU9", "WBGene00006920", "Q22494", "WBGene00020507", "Q23680", "WBGene00006918", "P34462", "WBGene00010130", "Q9XW92", "WBGene00013025", "Q19626", "WBGene00006921", "Q9N5A0", "WBGene00004959", "Q95X44", "WBGene00006917", "P91303", "WBGene00006919", "C0HLB3", "WBGene00006911", "C0HLB4", "WBGene00006912", "Q95YD5", "WBGene00016258", "G5EEK9", "WBGene00006914", "G5EGP4", "WBGene00006915", "P30628", "WBGene00006768", "B2MZD0", "WBGene00006916", "Q20591", "WBGene00009882", "G5EDB8", "WBGene00006913", "Q19425", "WBGene00008774", "species_29468" ] }, "reaction_10557938": { "compartment": "compartment_7660", "id": "reaction_10557938", "reactome": "R-CEL-6782141", "name": "Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10557934", "species_10508627" ], "products": [ "species_10557936" ], "modifiers": [], "additional_components": [ "Q95Y97", "WBGene00019767", "Q23088", "WBGene00022812", "Q7JKC3", "WBGene00010406", "P34545", "WBGene00000366", "Q21302", "WBGene00006963", "H2KYV0", "WBGene00016115", "P52652", "WBGene00012000", "Q18963", "WBGene00008403", "Q21554", "WBGene00010890", "Q23457", "WBGene00004320", "Q17392", "WBGene00000839", "Q19826", "WBGene00017830", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "O02092", "WBGene00018391", "Q9GR61", "WBGene00021347", "Q9N3C9", "WBGene00021845", "Q93338", "WBGene00007971", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q86D18", "WBGene00010011", "Q10051", "WBGene00020423", "Q20716", "WBGene00009966", "Q9U1Q7", "WBGene00001258", "Q9U2S6", "WBGene00000889", "P52009", "WBGene00000877", "P52016", "WBGene00000884", "P91175", "WBGene00016837", "Q22139", "WBGene00011411", "G5EBZ1", "WBGene00008140", "Q93456", "WBGene00008665", "G5EBZ1", "WBGene00008140", "Q93456", "WBGene00008665", "Q95Y97", "WBGene00019767", "Q23088", "WBGene00022812", "Q7JKC3", "WBGene00010406", "P34545", "WBGene00000366", "Q21302", "WBGene00006963", "H2KYV0", "WBGene00016115", "P52652", "WBGene00012000", "Q18963", "WBGene00008403", "Q21554", "WBGene00010890", "Q23457", "WBGene00004320", "Q17392", "WBGene00000839", "Q19826", "WBGene00017830", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "O02092", "WBGene00018391", "Q9GR61", "WBGene00021347", "Q9N3C9", "WBGene00021845", "Q93338", "WBGene00007971", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q86D18", "WBGene00010011", "Q10051", "WBGene00020423", "Q20716", "WBGene00009966", "Q9U1Q7", "WBGene00001258", "Q9U2S6", "WBGene00000889", "P52009", "WBGene00000877", "P52016", "WBGene00000884", "P91175", "WBGene00016837", "Q22139", "WBGene00011411" ] }, "reaction_10573109": { "compartment": "compartment_7660", "id": "reaction_10573109", "reactome": "R-CEL-9684118", "name": "ERCC3-facilitated RNA Pol II backtracking in TC-NER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10557921" ], "products": [ "species_113550", "species_113582", "species_10557932" ], "modifiers": [ [ "species_10557921", "catalyst" ] ], "additional_components": [ "Q23088", "WBGene00022812", "Q7JKC3", "WBGene00010406", "P34545", "WBGene00000366", "Q21302", "WBGene00006963", "H2KYV0", "WBGene00016115", "P52652", "WBGene00012000", "Q10051", "WBGene00020423", "Q20716", "WBGene00009966", "Q9U1Q7", "WBGene00001258", "Q9U2S6", "WBGene00000889", "P52009", "WBGene00000877", "P52016", "WBGene00000884", "P91175", "WBGene00016837", "Q22139", "WBGene00011411", "Q18963", "WBGene00008403", "Q21554", "WBGene00010890", "Q23457", "WBGene00004320", "Q17392", "WBGene00000839", "Q19826", "WBGene00017830", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "O02092", "WBGene00018391", "Q9GR61", "WBGene00021347", "Q9N3C9", "WBGene00021845", "Q93338", "WBGene00007971", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q86D18", "WBGene00010011", "Q23088", "WBGene00022812", "Q7JKC3", "WBGene00010406", "P34545", "WBGene00000366", "Q21302", "WBGene00006963", "H2KYV0", "WBGene00016115", "P52652", "WBGene00012000", "Q18963", "WBGene00008403", "Q21554", "WBGene00010890", "Q23457", "WBGene00004320", "Q17392", "WBGene00000839", "Q19826", "WBGene00017830", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "O02092", "WBGene00018391", "Q9GR61", "WBGene00021347", "Q9N3C9", "WBGene00021845", "Q93338", "WBGene00007971", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q86D18", "WBGene00010011", "Q10051", "WBGene00020423", "Q20716", "WBGene00009966", "Q9U1Q7", "WBGene00001258", "Q9U2S6", "WBGene00000889", "P52009", "WBGene00000877", "P52016", "WBGene00000884", "P91175", "WBGene00016837", "Q22139", "WBGene00011411", "Q23088", "WBGene00022812", "Q7JKC3", "WBGene00010406", "P34545", "WBGene00000366", "Q21302", "WBGene00006963", "H2KYV0", "WBGene00016115", "P52652", "WBGene00012000", "Q10051", "WBGene00020423", "Q20716", "WBGene00009966", "Q9U1Q7", "WBGene00001258", "Q9U2S6", "WBGene00000889", "P52009", "WBGene00000877", "P52016", "WBGene00000884", "P91175", "WBGene00016837", "Q22139", "WBGene00011411", "Q18963", "WBGene00008403", "Q21554", "WBGene00010890", "Q23457", "WBGene00004320", "Q17392", "WBGene00000839", "Q19826", "WBGene00017830", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "O02092", "WBGene00018391", "Q9GR61", "WBGene00021347", "Q9N3C9", "WBGene00021845", "Q93338", "WBGene00007971", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q86D18", "WBGene00010011" ] }, "reaction_10557924": { "compartment": "compartment_7660", "id": "reaction_10557924", "reactome": "R-CEL-6782131", "name": "ERCC2-facilitated RNA Pol II backtracking in TC-NER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10557910" ], "products": [ "species_113550", "species_113582", "species_10557921" ], "modifiers": [ [ "species_10557910", "catalyst" ] ], "additional_components": [ "Q23088", "WBGene00022812", "Q7JKC3", "WBGene00010406", "P34545", "WBGene00000366", "Q18963", "WBGene00008403", "Q21554", "WBGene00010890", "Q23457", "WBGene00004320", "Q17392", "WBGene00000839", "Q19826", "WBGene00017830", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "O02092", "WBGene00018391", "Q9GR61", "WBGene00021347", "Q9N3C9", "WBGene00021845", "Q93338", "WBGene00007971", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q86D18", "WBGene00010011", "Q21302", "WBGene00006963", "H2KYV0", "WBGene00016115", "P52652", "WBGene00012000", "Q10051", "WBGene00020423", "Q20716", "WBGene00009966", "Q9U1Q7", "WBGene00001258", "Q9U2S6", "WBGene00000889", "P52009", "WBGene00000877", "P52016", "WBGene00000884", "P91175", "WBGene00016837", "Q22139", "WBGene00011411", "Q23088", "WBGene00022812", "Q7JKC3", "WBGene00010406", "P34545", "WBGene00000366", "Q21302", "WBGene00006963", "H2KYV0", "WBGene00016115", "P52652", "WBGene00012000", "Q10051", "WBGene00020423", "Q20716", "WBGene00009966", "Q9U1Q7", "WBGene00001258", "Q9U2S6", "WBGene00000889", "P52009", "WBGene00000877", "P52016", "WBGene00000884", "P91175", "WBGene00016837", "Q22139", "WBGene00011411", "Q18963", "WBGene00008403", "Q21554", "WBGene00010890", "Q23457", "WBGene00004320", "Q17392", "WBGene00000839", "Q19826", "WBGene00017830", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "O02092", "WBGene00018391", "Q9GR61", "WBGene00021347", "Q9N3C9", "WBGene00021845", "Q93338", "WBGene00007971", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q86D18", "WBGene00010011", "Q23088", "WBGene00022812", "Q7JKC3", "WBGene00010406", "P34545", "WBGene00000366", "Q18963", "WBGene00008403", "Q21554", "WBGene00010890", "Q23457", "WBGene00004320", "Q17392", "WBGene00000839", "Q19826", "WBGene00017830", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "O02092", "WBGene00018391", "Q9GR61", "WBGene00021347", "Q9N3C9", "WBGene00021845", "Q93338", "WBGene00007971", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q86D18", "WBGene00010011", "Q21302", "WBGene00006963", "H2KYV0", "WBGene00016115", "P52652", "WBGene00012000", "Q10051", "WBGene00020423", "Q20716", "WBGene00009966", "Q9U1Q7", "WBGene00001258", "Q9U2S6", "WBGene00000889", "P52009", "WBGene00000877", "P52016", "WBGene00000884", "P91175", "WBGene00016837", "Q22139", "WBGene00011411" ] }, "reaction_10557943": { "compartment": "compartment_7660", "id": "reaction_10557943", "reactome": "R-CEL-6782204", "name": "5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10557936" ], "products": [ "species_10557940" ], "modifiers": [ [ "species_10557936", "catalyst" ] ], "additional_components": [ "G5EBZ1", "WBGene00008140", "Q93456", "WBGene00008665", "Q95Y97", "WBGene00019767", "Q23088", "WBGene00022812", "Q7JKC3", "WBGene00010406", "P34545", "WBGene00000366", "Q21302", "WBGene00006963", "H2KYV0", "WBGene00016115", "P52652", "WBGene00012000", "Q18963", "WBGene00008403", "Q21554", "WBGene00010890", "Q23457", "WBGene00004320", "Q17392", "WBGene00000839", "Q19826", "WBGene00017830", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "O02092", "WBGene00018391", "Q9GR61", "WBGene00021347", "Q9N3C9", "WBGene00021845", "Q93338", "WBGene00007971", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q86D18", "WBGene00010011", "Q10051", "WBGene00020423", "Q20716", "WBGene00009966", "Q9U1Q7", "WBGene00001258", "Q9U2S6", "WBGene00000889", "P52009", "WBGene00000877", "P52016", "WBGene00000884", "P91175", "WBGene00016837", "Q22139", "WBGene00011411", "Q18963", "WBGene00008403", "Q21554", "WBGene00010890", "Q23457", "WBGene00004320", "Q17392", "WBGene00000839", "P34545", "WBGene00000366", "Q23088", "WBGene00022812", "Q7JKC3", "WBGene00010406", "Q21302", "WBGene00006963", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q10051", "WBGene00020423", "Q20716", "WBGene00009966", "Q9U1Q7", "WBGene00001258", "Q9U2S6", "WBGene00000889", "P52009", "WBGene00000877", "P52016", "WBGene00000884", "P91175", "WBGene00016837", "Q22139", "WBGene00011411", "Q95Y97", "WBGene00019767", "Q19826", "WBGene00017830", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "O02092", "WBGene00018391", "Q9GR61", "WBGene00021347", "Q9N3C9", "WBGene00021845", "Q93338", "WBGene00007971", "G5EBZ1", "WBGene00008140", "Q93456", "WBGene00008665", "H2KYV0", "WBGene00016115", "P52652", "WBGene00012000", "Q86D18", "WBGene00010011", "G5EBZ1", "WBGene00008140", "Q93456", "WBGene00008665", "Q95Y97", "WBGene00019767", "Q23088", "WBGene00022812", "Q7JKC3", "WBGene00010406", "P34545", "WBGene00000366", "Q21302", "WBGene00006963", "H2KYV0", "WBGene00016115", "P52652", "WBGene00012000", "Q18963", "WBGene00008403", "Q21554", "WBGene00010890", "Q23457", "WBGene00004320", "Q17392", "WBGene00000839", "Q19826", "WBGene00017830", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "O02092", "WBGene00018391", "Q9GR61", "WBGene00021347", "Q9N3C9", "WBGene00021845", "Q93338", "WBGene00007971", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q86D18", "WBGene00010011", "Q10051", "WBGene00020423", "Q20716", "WBGene00009966", "Q9U1Q7", "WBGene00001258", "Q9U2S6", "WBGene00000889", "P52009", "WBGene00000877", "P52016", "WBGene00000884", "P91175", "WBGene00016837", "Q22139", "WBGene00011411" ] }, "reaction_10557958": { "compartment": "compartment_7660", "id": "reaction_10557958", "reactome": "R-CEL-6782211", "name": "DNA polymerases delta, epsilon or kappa bind the TC-NER site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10557940", "species_10557954", "species_10502642", "species_10557952" ], "products": [ "species_10557956" ], "modifiers": [], "additional_components": [ "Q18963", "WBGene00008403", "Q21554", "WBGene00010890", "Q23457", "WBGene00004320", "Q17392", "WBGene00000839", "P34545", "WBGene00000366", "Q23088", "WBGene00022812", "Q7JKC3", "WBGene00010406", "Q21302", "WBGene00006963", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q10051", "WBGene00020423", "Q20716", "WBGene00009966", "Q9U1Q7", "WBGene00001258", "Q9U2S6", "WBGene00000889", "P52009", "WBGene00000877", "P52016", "WBGene00000884", "P91175", "WBGene00016837", "Q22139", "WBGene00011411", "Q95Y97", "WBGene00019767", "Q19826", "WBGene00017830", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "O02092", "WBGene00018391", "Q9GR61", "WBGene00021347", "Q9N3C9", "WBGene00021845", "Q93338", "WBGene00007971", "G5EBZ1", "WBGene00008140", "Q93456", "WBGene00008665", "H2KYV0", "WBGene00016115", "P52652", "WBGene00012000", "Q86D18", "WBGene00010011", "O02115", "WBGene00003955", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "P90829", "WBGene00008645", "Q19366", "WBGene00008722", "Q21730", "WBGene00011016", "P34409", "WBGene00017696", "Q95Y97", "WBGene00019767", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "P90829", "WBGene00008645", "Q19366", "WBGene00008722", "Q21730", "WBGene00011016", "O02115", "WBGene00003955", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "P34409", "WBGene00017696", "Q18963", "WBGene00008403", "Q21554", "WBGene00010890", "Q23457", "WBGene00004320", "Q17392", "WBGene00000839", "P34545", "WBGene00000366", "Q23088", "WBGene00022812", "Q7JKC3", "WBGene00010406", "Q21302", "WBGene00006963", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q10051", "WBGene00020423", "Q20716", "WBGene00009966", "Q9U1Q7", "WBGene00001258", "Q9U2S6", "WBGene00000889", "P52009", "WBGene00000877", "P52016", "WBGene00000884", "P91175", "WBGene00016837", "Q22139", "WBGene00011411", "Q19826", "WBGene00017830", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "O02092", "WBGene00018391", "Q9GR61", "WBGene00021347", "Q9N3C9", "WBGene00021845", "Q93338", "WBGene00007971", "G5EBZ1", "WBGene00008140", "Q93456", "WBGene00008665", "H2KYV0", "WBGene00016115", "P52652", "WBGene00012000", "Q86D18", "WBGene00010011" ] }, "reaction_10553056": { "compartment": "compartment_70101", "id": "reaction_10553056", "reactome": "R-CEL-5618105", "name": "FKBP5 binds HSP90:ATP:STIP1:HSP70:nascent protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10553038", "species_10552844" ], "products": [ "species_10553046" ], "modifiers": [], "additional_components": [ "P09446", "WBGene00002005", "G5ECU5", "WBGene00009691", "O45246", "WBGene00002026", "G5EC99", "WBGene00009691", "species_113582", "O16259", "WBGene00019983", "Q18688", "WBGene00000915", "species_29358", "WBGene00001431", "O45418", "WBGene00001431", "P09446", "WBGene00002005", "G5ECU5", "WBGene00009691", "O45246", "WBGene00002026", "G5EC99", "WBGene00009691", "species_113582", "O16259", "WBGene00019983", "Q18688", "WBGene00000915", "species_29358" ] }, "reaction_10573120": { "compartment": "compartment_70101", "id": "reaction_10573120", "reactome": "R-CEL-9690534", "name": "SH binds NR3C1 (in HSP90:ATP:FKBP4:PTGES3:NR3C1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10552862", "species_5618094" ], "products": [ "species_10552864" ], "modifiers": [ [ "species_10573086", "catalyst" ] ], "additional_components": [ "O45418", "WBGene00001431", "Q18688", "WBGene00000915", "species_29358", "Q23280", "WBGene00022599", "species_193057", "species_469662", "CHEBI:16973", "species_193977", "CHEBI:27584", "CHEBI:17026", "species_193057", "species_469662", "CHEBI:16973", "species_193977", "CHEBI:27584", "CHEBI:17026", "O45418", "WBGene00001431", "Q18688", "WBGene00000915", "species_29358", "Q23280", "WBGene00022599", "O45418", "WBGene00001431", "Q18688", "WBGene00000915", "species_29358", "Q23280", "WBGene00022599" ] }, "reaction_10573088": { "compartment": "compartment_70101", "id": "reaction_10573088", "reactome": "R-CEL-9678925", "name": "NR3C1 binds NR3C1 agonists", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10552862", "species_9678859" ], "products": [ "species_10573086" ], "modifiers": [], "additional_components": [ "O45418", "WBGene00001431", "Q18688", "WBGene00000915", "species_29358", "Q23280", "WBGene00022599", "O45418", "WBGene00001431", "Q18688", "WBGene00000915", "species_29358", "Q23280", "WBGene00022599" ] }, "reaction_10547715": { "compartment": "compartment_70101", "id": "reaction_10547715", "reactome": "R-CEL-3371590", "name": "HSP70 binds to HSP40:nascent protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10547711", "species_10547713" ], "products": [ "species_10547586" ], "modifiers": [], "additional_components": [ "O45502", "WBGene00001030", "O16303", "WBGene00001037", "P09446", "WBGene00002005", "G5ECU5", "WBGene00009691", "O45246", "WBGene00002026", "G5EC99", "WBGene00009691", "species_29358", "P09446", "WBGene00002005", "G5ECU5", "WBGene00009691", "O45246", "WBGene00002026", "G5EC99", "WBGene00009691", "O45502", "WBGene00001030", "O16303", "WBGene00001037", "species_29358" ] }, "reaction_10553058": { "compartment": "compartment_70101", "id": "reaction_10553058", "reactome": "R-CEL-5618107", "name": "ATP binding to HSP90 triggers conformation change", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10547658", "species_113592" ], "products": [ "species_10553038" ], "modifiers": [], "additional_components": [ "Q18688", "WBGene00000915", "P09446", "WBGene00002005", "G5ECU5", "WBGene00009691", "O45246", "WBGene00002026", "G5EC99", "WBGene00009691", "species_113582", "O16259", "WBGene00019983", "P09446", "WBGene00002005", "G5ECU5", "WBGene00009691", "O45246", "WBGene00002026", "G5EC99", "WBGene00009691", "species_113582", "O16259", "WBGene00019983", "Q18688", "WBGene00000915", "species_29358" ] }, "reaction_10553060": { "compartment": "compartment_70101", "id": "reaction_10553060", "reactome": "R-CEL-5618110", "name": "p23 (PTGES3) binds HSP90:ATP:FKBP4:nascent protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10517708", "species_10553040" ], "products": [ "species_10547646", "species_10552852", "species_10547713" ], "modifiers": [], "additional_components": [ "WBGene00022599", "O45418", "WBGene00001431", "P09446", "WBGene00002005", "G5ECU5", "WBGene00009691", "O45246", "WBGene00002026", "G5EC99", "WBGene00009691", "species_113582", "O16259", "WBGene00019983", "Q18688", "WBGene00000915", "species_29358", "WBGene00019983", "O45418", "WBGene00001431", "Q23280", "WBGene00022599", "Q18688", "WBGene00000915", "species_29358", "P09446", "WBGene00002005", "G5ECU5", "WBGene00009691", "O45246", "WBGene00002026", "G5EC99", "WBGene00009691", "species_29358" ] }, "reaction_10547591": { "compartment": "compartment_70101", "id": "reaction_10547591", "reactome": "R-CEL-3371422", "name": "ATP hydrolysis by HSP70", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10547586" ], "products": [ "species_29372", "species_10547588" ], "modifiers": [ [ "species_10547586", "catalyst" ], [ "species_10547584", "catalyst" ] ], "additional_components": [ "P09446", "WBGene00002005", "G5ECU5", "WBGene00009691", "O45246", "WBGene00002026", "G5EC99", "WBGene00009691", "O45502", "WBGene00001030", "O16303", "WBGene00001037", "species_29358", "P09446", "WBGene00002005", "G5ECU5", "WBGene00009691", "O45246", "WBGene00002026", "G5EC99", "WBGene00009691", "O45502", "WBGene00001030", "O16303", "WBGene00001037", "species_113582", "P09446", "WBGene00002005", "G5ECU5", "WBGene00009691", "O45246", "WBGene00002026", "G5EC99", "WBGene00009691", "O45502", "WBGene00001030", "O16303", "WBGene00001037", "species_29358", "O45502", "WBGene00001030", "O16303", "WBGene00001037" ] }, "reaction_10553035": { "compartment": "compartment_70101", "id": "reaction_10553035", "reactome": "R-CEL-5618080", "name": "HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10552858", "species_10552864" ], "products": [ "species_10552874", "species_10552868" ], "modifiers": [ [ "species_10553033", "catalyst" ] ], "additional_components": [ "O45418", "WBGene00001431", "Q18688", "WBGene00000915", "species_29358", "Q23280", "WBGene00022599", "species_193057", "species_469662", "CHEBI:16973", "species_193977", "CHEBI:27584", "CHEBI:17026", "O45418", "WBGene00001431", "Q18688", "WBGene00000915", "species_29358", "Q23280", "WBGene00022599", "species_469662", "species_193977", "CHEBI:17026", "CHEBI:27584", "CHEBI:16973", "species_193057", "O45418", "WBGene00001431", "Q23280", "WBGene00022599", "Q18688", "WBGene00000915", "species_29358", "O45418", "WBGene00001431", "Q23280", "WBGene00022599", "Q18688", "WBGene00000915", "species_29358", "Q19020", "WBGene00000962", "O45087", "WBGene00015927", "Q65XS9", "WBGene00043067", "A0AAC1", "WBGene00012424", "Q7YTJ8", "WBGene00012425", "Q21557", "WBGene00010888", "Q22799", "WBGene00001005", "G5ED34", "WBGene00001007", "species_29420", "species_29438", "Q9NA98", "WBGene00013168", "P34685", "WBGene00000292", "P34686", "WBGene00000293", "Q18194", "WBGene00016124", "Q9N4I1", "WBGene00022118", "Q9N3F1", "WBGene00021827", "Q9GYR2", "WBGene00016793", "Q09248", "WBGene00001018", "E2JKZ0", "WBGene00001017" ] }, "reaction_10547660": { "compartment": "compartment_70101", "id": "reaction_10547660", "reactome": "R-CEL-3371503", "name": "STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10547646", "species_10547588", "species_10547652" ], "products": [ "species_10547658", "species_10547584" ], "modifiers": [], "additional_components": [ "WBGene00019983", "P09446", "WBGene00002005", "G5ECU5", "WBGene00009691", "O45246", "WBGene00002026", "G5EC99", "WBGene00009691", "O45502", "WBGene00001030", "O16303", "WBGene00001037", "species_113582", "Q18688", "WBGene00000915", "Q18688", "WBGene00000915", "P09446", "WBGene00002005", "G5ECU5", "WBGene00009691", "O45246", "WBGene00002026", "G5EC99", "WBGene00009691", "species_113582", "O16259", "WBGene00019983", "O45502", "WBGene00001030", "O16303", "WBGene00001037" ] }, "reaction_10573294": { "compartment": "compartment_70101", "id": "reaction_10573294", "reactome": "R-CEL-9705925", "name": "Androgens binds AR (in the HSP90 chaperone complex)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8979218", "species_10573288" ], "products": [ "species_10573292" ], "modifiers": [], "additional_components": [ "species_193057", "species_193079", "species_469662", "CHEBI:29117", "O45418", "WBGene00001431", "Q18688", "WBGene00000915", "species_29358", "Q23280", "WBGene00022599", "O45418", "WBGene00001431", "Q18688", "WBGene00000915", "species_29358", "species_193057", "species_193079", "species_469662", "CHEBI:29117", "Q23280", "WBGene00022599" ] }, "reaction_10553042": { "compartment": "compartment_70101", "id": "reaction_10553042", "reactome": "R-CEL-5618085", "name": "FKBP4 binds HSP90:ATP:STIP1:HSP70:nascent protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10553038", "species_10552850" ], "products": [ "species_10553040" ], "modifiers": [], "additional_components": [ "P09446", "WBGene00002005", "G5ECU5", "WBGene00009691", "O45246", "WBGene00002026", "G5EC99", "WBGene00009691", "species_113582", "O16259", "WBGene00019983", "Q18688", "WBGene00000915", "species_29358", "WBGene00001431", "O45418", "WBGene00001431", "P09446", "WBGene00002005", "G5ECU5", "WBGene00009691", "O45246", "WBGene00002026", "G5EC99", "WBGene00009691", "species_113582", "O16259", "WBGene00019983", "Q18688", "WBGene00000915", "species_29358" ] }, "reaction_10552854": { "compartment": "compartment_70101", "id": "reaction_10552854", "reactome": "R-CEL-5618073", "name": "FKBP4 replaces FKBP5 within HSP90:ATP:FKBP5:unfolded protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10552850", "species_10552848" ], "products": [ "species_10552844", "species_10552852" ], "modifiers": [ [ "species_5618094", "catalyst" ] ], "additional_components": [ "WBGene00001431", "Q23280", "WBGene00022599", "O45418", "WBGene00001431", "Q18688", "WBGene00000915", "species_29358", "WBGene00001431", "O45418", "WBGene00001431", "Q23280", "WBGene00022599", "Q18688", "WBGene00000915", "species_29358", "species_193057", "species_469662", "CHEBI:16973", "species_193977", "CHEBI:27584", "CHEBI:17026" ] }, "reaction_10553048": { "compartment": "compartment_70101", "id": "reaction_10553048", "reactome": "R-CEL-5618098", "name": "p23 (PTGES3) binds HSP90:ATP:FKBP5:nascent protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10517708", "species_10553046" ], "products": [ "species_10547646", "species_10547713", "species_10552848" ], "modifiers": [], "additional_components": [ "WBGene00022599", "O45418", "WBGene00001431", "P09446", "WBGene00002005", "G5ECU5", "WBGene00009691", "O45246", "WBGene00002026", "G5EC99", "WBGene00009691", "species_113582", "O16259", "WBGene00019983", "Q18688", "WBGene00000915", "species_29358", "WBGene00019983", "P09446", "WBGene00002005", "G5ECU5", "WBGene00009691", "O45246", "WBGene00002026", "G5EC99", "WBGene00009691", "species_29358", "Q23280", "WBGene00022599", "O45418", "WBGene00001431", "Q18688", "WBGene00000915", "species_29358" ] }, "reaction_10553054": { "compartment": "compartment_70101", "id": "reaction_10553054", "reactome": "R-CEL-5618099", "name": "SH binds SHR within the HSP90 chaperone complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10553052", "species_5618094" ], "products": [ "species_10552858" ], "modifiers": [], "additional_components": [ "O45418", "WBGene00001431", "Q18688", "WBGene00000915", "species_29358", "Q23280", "WBGene00022599", "species_193057", "species_469662", "CHEBI:16973", "species_193977", "CHEBI:27584", "CHEBI:17026", "O45418", "WBGene00001431", "Q18688", "WBGene00000915", "species_29358", "Q23280", "WBGene00022599" ] }, "reaction_10532184": { "compartment": "compartment_70101", "id": "reaction_10532184", "reactome": "R-CEL-1234161", "name": "HIF-alpha translocates from cytosol to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10532172" ], "products": [ "species_10532178" ], "modifiers": [], "additional_components": [ "WBGene00001851", "WBGene00001851" ] }, "reaction_10532232": { "compartment": "compartment_7660", "id": "reaction_10532232", "reactome": "R-CEL-1234167", "name": "Formation of HIF:CBP:p300 complex at promoters", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10532221", "species_29428", "species_10532228", "species_10532226" ], "products": [ "species_10532230" ], "modifiers": [], "additional_components": [ "G5EGD2", "WBGene00001851", "O02219", "WBGene00000095", "WBGene00000366", "WBGene00000366", "P34545", "WBGene00000366", "G5EGD2", "WBGene00001851", "O02219", "WBGene00000095" ] }, "reaction_10532250": { "compartment": "compartment_7660", "id": "reaction_10532250", "reactome": "R-CEL-1234171", "name": "HIF-alpha binds ARNT (HIF1-beta) forming HIF-alpha:ARNT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10532219", "species_10532178" ], "products": [ "species_10532221" ], "modifiers": [], "additional_components": [ "WBGene00000095", "WBGene00001851", "G5EGD2", "WBGene00001851", "O02219", "WBGene00000095" ] }, "reaction_10518832": { "compartment": "compartment_984", "id": "reaction_10518832", "reactome": "R-CEL-374919", "name": "Noradrenaline clearance from the synaptic cleft", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_374935" ], "products": [ "species_209789" ], "modifiers": [ [ "species_10518786", "catalyst" ] ], "additional_components": [ "WBGene00003987" ] }, "reaction_10572361": { "compartment": "compartment_876", "id": "reaction_10572361", "reactome": "R-CEL-9634834", "name": "ACHEIs bind ACHE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10518366", "species_9634838" ], "products": [ "species_10518393" ], "modifiers": [], "additional_components": [ "Q23268", "WBGene00013873", "Q04457", "WBGene00001578", "H9G2Y9", "WBGene00013874", "A0A1C3NSL8", "WBGene00017478", "Q4LDP0", "WBGene00020891", "Q21266", "WBGene00019477", "O01302", "WBGene00011362", "G5EDJ7", "WBGene00013875", "Q9XW75", "WBGene00013540", "Q22008", "WBGene00020125", "P92016", "WBGene00011364", "H2L0K7", "WBGene00020330", "Q23268", "WBGene00013873", "Q04457", "WBGene00001578", "H9G2Y9", "WBGene00013874", "A0A1C3NSL8", "WBGene00017478", "Q4LDP0", "WBGene00020891", "Q21266", "WBGene00019477", "O01302", "WBGene00011362", "G5EDJ7", "WBGene00013875", "Q9XW75", "WBGene00013540", "Q22008", "WBGene00020125", "P92016", "WBGene00011364", "H2L0K7", "WBGene00020330" ] }, "reaction_10567745": { "compartment": "compartment_20699", "id": "reaction_10567745", "reactome": "R-CEL-8877813", "name": "DENND5A,B exchange GTP for GDP on RAB39", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10567729" ], "products": [ "species_29420", "species_10567735", "species_10567253" ], "modifiers": [ [ "species_10567740", "catalyst" ] ], "additional_components": [ "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "Q18969", "WBGene00004286", "species_29420", "Q18969", "WBGene00004286", "species_29438", "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "WBGene00016889" ] }, "reaction_10567680": { "compartment": "compartment_13946", "id": "reaction_10567680", "reactome": "R-CEL-8877475", "name": "TRAPPC complexes exchange GTP for GDP on RAB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10567646", "species_29438" ], "products": [ "species_29420", "species_10567656", "species_10567253" ], "modifiers": [ [ "species_10567677", "catalyst" ] ], "additional_components": [ "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "Q9UAQ6", "WBGene00004266", "species_29420", "Q9UAQ6", "WBGene00004266", "species_29438", "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "Q9NA81", "WBGene00013259", "B1GRL5", "WBGene00077643", "Q93330", "WBGene00007956", "B1V899", "WBGene00022138", "Q9XU81", "WBGene00010699", "O02173", "WBGene00021046", "Q5WRR4", "WBGene00016614", "G4SNB8", "WBGene00044604", "Q95QQ2", "WBGene00016964", "P34605", "WBGene00014222", "Q9BI63", "WBGene00018512", "Q20100", "WBGene00018088" ] }, "reaction_10567296": { "compartment": "compartment_171062", "id": "reaction_10567296", "reactome": "R-CEL-8875320", "name": "RAB5 GEFs exchange GTP for GDP on RAB5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10567270" ], "products": [ "species_10567278", "species_29420", "species_10567253" ], "modifiers": [ [ "species_10567293", "catalyst" ] ], "additional_components": [ "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "P91857", "WBGene00004268", "species_29420", "P91857", "WBGene00004268", "species_29438", "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "G5ECF0", "WBGene00008183", "A0A486WY48", "WBGene00012644", "Q9GYH7", "WBGene00004377" ] }, "reaction_10567266": { "compartment": "compartment_216813", "id": "reaction_10567266", "reactome": "R-CEL-8875318", "name": "RAB3 GEFs exchange GTP for GDP on RAB3A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10567255" ], "products": [ "species_29420", "species_10567259", "species_10567253" ], "modifiers": [ [ "species_10567263", "catalyst" ] ], "additional_components": [ "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "Q94986", "WBGene00004267", "species_29420", "Q94986", "WBGene00004267", "species_29438", "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "O02626", "WBGene00000086", "Q20759", "WBGene00010045" ] }, "reaction_10567429": { "compartment": "compartment_263163", "id": "reaction_10567429", "reactome": "R-CEL-8876190", "name": "RAB8 GEFs exchange GTP for GDP on RAB8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10567407", "species_29438" ], "products": [ "species_29420", "species_10567419", "species_10567253" ], "modifiers": [ [ "species_10567426", "catalyst" ] ], "additional_components": [ "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "G5EFC1", "WBGene00004272", "Q21137", "WBGene00019317", "species_29420", "G5EFC1", "WBGene00004272", "Q21137", "WBGene00019317", "species_29438", "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "Q20759", "WBGene00010045" ] }, "reaction_10567401": { "compartment": "compartment_437051", "id": "reaction_10567401", "reactome": "R-CEL-8876188", "name": "DENND4s exchange GTP for GDP on RAB10", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10567385" ], "products": [ "species_10567389", "species_29420", "species_10567253" ], "modifiers": [ [ "species_10567394", "catalyst" ] ], "additional_components": [ "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "Q94148", "WBGene00004273", "species_29420", "Q94148", "WBGene00004273", "species_29438", "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "WBGene00018681" ] }, "reaction_10567468": { "compartment": "compartment_70101", "id": "reaction_10567468", "reactome": "R-CEL-8876446", "name": "p-ULK1 phosphorylates DENND3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10567461" ], "products": [ "species_29370", "species_10567465" ], "modifiers": [ [ "species_10554852", "catalyst" ] ], "additional_components": [ "WBGene00018681", "WBGene00018681", "WBGene00006786" ] }, "reaction_10568111": { "compartment": "compartment_70101", "id": "reaction_10568111", "reactome": "R-CEL-8933446", "name": "Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10567690", "species_113592" ], "products": [ "species_10568106", "species_29370" ], "modifiers": [ [ "species_10513848", "catalyst" ] ], "additional_components": [ "WBGene00004375", "WBGene00004375", "Q9XTG7", "WBGene00000103", "G4S4W1", "WBGene00016980", "Q17941", "WBGene00000102" ] }, "reaction_10567695": { "compartment": "compartment_262783", "id": "reaction_10567695", "reactome": "R-CEL-8877612", "name": "DENND1s exchange GTP for GDP on RAB35", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10567684" ], "products": [ "species_29420", "species_10567688", "species_10567253" ], "modifiers": [ [ "species_10567690", "catalyst" ] ], "additional_components": [ "species_29420", "Q9U2C3", "WBGene00004284", "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "Q9U2C3", "WBGene00004284", "species_29438", "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "WBGene00004375" ] }, "reaction_10567569": { "compartment": "compartment_171062", "id": "reaction_10567569", "reactome": "R-CEL-8876837", "name": "RAB21 GEFs exchange GTP for GDP on RAB21", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10567558" ], "products": [ "species_29420", "species_10567562", "species_10567253" ], "modifiers": [ [ "species_10567564", "catalyst" ] ], "additional_components": [ "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "Q22045", "WBGene00004279", "species_29420", "Q22045", "WBGene00004279", "species_29438", "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "WBGene00003477" ] }, "reaction_10567536": { "compartment": "compartment_70101", "id": "reaction_10567536", "reactome": "R-CEL-8876616", "name": "DENND6A,B exchange GTP for GDP on RAB14", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10567520" ], "products": [ "species_29420", "species_10567524", "species_10567253" ], "modifiers": [ [ "species_10567533", "catalyst" ] ], "additional_components": [ "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "Q93874", "WBGene00004276", "species_29420", "Q93874", "WBGene00004276", "species_29438", "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "O45074", "WBGene00018777" ] }, "reaction_10567638": { "compartment": "compartment_17938", "id": "reaction_10567638", "reactome": "R-CEL-8877451", "name": "MON1:CCZ1 exchanges GTP for GDP on RAB7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10567615", "species_29438" ], "products": [ "species_29420", "species_10567621", "species_10567253" ], "modifiers": [ [ "species_10567635", "catalyst" ] ], "additional_components": [ "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "species_29420", "Q23146", "WBGene00004271", "Q23146", "WBGene00004271", "species_29438", "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "Q9XVL8", "WBGene00010283", "Q9BI89", "WBGene00018321" ] }, "reaction_10567611": { "compartment": "compartment_5668575", "id": "reaction_10567611", "reactome": "R-CEL-8877308", "name": "MADD exchanges GTP for GDP on RAB27", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10567598", "species_29438" ], "products": [ "species_29420", "species_10567608", "species_10567253" ], "modifiers": [ [ "species_10553865", "catalyst" ] ], "additional_components": [ "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "G5EBS5", "WBGene00000089", "species_29420", "G5EBS5", "WBGene00000089", "species_29438", "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "WBGene00000086" ] }, "reaction_10567485": { "compartment": "compartment_262783", "id": "reaction_10567485", "reactome": "R-CEL-8876454", "name": "DENND3 exchanges GTP for GDP on RAB12", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10567472" ], "products": [ "species_29420", "species_10567480", "species_10567253" ], "modifiers": [ [ "species_10567482", "catalyst" ] ], "additional_components": [ "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "Q21137", "WBGene00019317", "G5EFC1", "WBGene00004272", "species_29420", "G5EFC1", "WBGene00004272", "Q21137", "WBGene00019317", "species_29438", "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "U4PBM1", "WBGene00018681" ] }, "reaction_10567516": { "compartment": "compartment_204883", "id": "reaction_10567516", "reactome": "R-CEL-8876615", "name": "RAB13 GEFs exchange GTP for GDP on RAB13", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10567503", "species_29438" ], "products": [ "species_29420", "species_10567511", "species_10567253" ], "modifiers": [ [ "species_10567513", "catalyst" ] ], "additional_components": [ "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "species_29420", "G5EFC1", "WBGene00004272", "Q21137", "WBGene00019317", "G5EFC1", "WBGene00004272", "Q21137", "WBGene00019317", "species_29438", "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051" ] }, "reaction_10567454": { "compartment": "compartment_263163", "id": "reaction_10567454", "reactome": "R-CEL-8876193", "name": "RIC1-RGP1 exchanges GTP for GDP on RAB6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10567435" ], "products": [ "species_29420", "species_10567451", "species_10567253" ], "modifiers": [ [ "species_10564567", "catalyst" ] ], "additional_components": [ "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "Q22782", "WBGene00004270", "P34213", "WBGene00004269", "species_29420", "P34213", "WBGene00004269", "Q22782", "WBGene00004270", "species_29438", "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "Q7YWW8", "WBGene00010815", "Q09417", "WBGene00011071" ] }, "reaction_10567774": { "compartment": "compartment_12045", "id": "reaction_10567774", "reactome": "R-CEL-8877998", "name": "RAB3GAP1:RAB3GAP2 exchanges GTP for GDP on RAB18", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10567761" ], "products": [ "species_29420", "species_10567253", "species_10567765" ], "modifiers": [ [ "species_10567771", "catalyst" ] ], "additional_components": [ "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "species_29420", "Q8MXS1", "WBGene00004277", "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "Q8MXS1", "WBGene00004277", "species_29438", "Q93538", "WBGene00004317", "Q22670", "WBGene00004318" ] }, "reaction_10518562": { "compartment": "compartment_876", "id": "reaction_10518562", "reactome": "R-CEL-373741", "name": "SDK2 homophillic interaction", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10518558" ], "products": [ "species_10518560" ], "modifiers": [], "additional_components": [ "Q19663", "WBGene00017657", "Q9N3X8", "WBGene00004371", "Q19663", "WBGene00017657", "Q9N3X8", "WBGene00004371" ] }, "reaction_10518572": { "compartment": "compartment_876", "id": "reaction_10518572", "reactome": "R-CEL-373745", "name": "SDK1 homophillic interaction", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10518568" ], "products": [ "species_10518570" ], "modifiers": [], "additional_components": [ "Q19663", "WBGene00017657", "Q9N3X8", "WBGene00004371", "Q19663", "WBGene00017657", "Q9N3X8", "WBGene00004371" ] }, "reaction_10524053": { "compartment": "compartment_70101", "id": "reaction_10524053", "reactome": "R-CEL-432909", "name": "Interaction of Plectin with Integrin beta 4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10517311", "species_10514921" ], "products": [ "species_10524051" ], "modifiers": [], "additional_components": [ "Q03600", "WBGene00002081", "Q27874", "WBGene00003930", "WBGene00006876", "A0A1N7SYP3", "WBGene00006876", "Q03600", "WBGene00002081", "Q27874", "WBGene00003930" ] }, "reaction_10524069": { "compartment": "compartment_984", "id": "reaction_10524069", "reactome": "R-CEL-432956", "name": "BP230 is recruited to the hemidesmosome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10524061", "species_10524065" ], "products": [ "species_10524067" ], "modifiers": [], "additional_components": [ "A0A1N7SYP3", "WBGene00006876", "Q03600", "WBGene00002081", "Q27874", "WBGene00003930", "O44565", "WBGene00002247", "Q18823", "WBGene00016913", "Q19981", "WBGene00006432", "G5EG68", "WBGene00018304", "Q06561", "WBGene00006787", "G5ECE3", "WBGene00002248", "Q21313", "WBGene00001328", "A0A1N7SYP3", "WBGene00006876", "Q03600", "WBGene00002081", "Q27874", "WBGene00003930", "O44565", "WBGene00002247", "Q18823", "WBGene00016913", "Q19981", "WBGene00006432", "G5EG68", "WBGene00018304", "Q06561", "WBGene00006787", "G5ECE3", "WBGene00002248", "Q21313", "WBGene00001328" ] }, "reaction_10525053": { "compartment": "compartment_984", "id": "reaction_10525053", "reactome": "R-CEL-446089", "name": "BP180 interacts extracellularly with Laminin 332", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10525051", "species_10517354" ], "products": [ "species_10524061" ], "modifiers": [], "additional_components": [ "A0A1N7SYP3", "WBGene00006876", "Q03600", "WBGene00002081", "Q27874", "WBGene00003930", "O44565", "WBGene00002247", "Q18823", "WBGene00016913", "Q19981", "WBGene00006432", "G5EG68", "WBGene00018304", "Q06561", "WBGene00006787", "G5ECE3", "WBGene00002248", "Q21313", "WBGene00001328", "A0A1N7SYP3", "WBGene00006876", "Q03600", "WBGene00002081", "Q27874", "WBGene00003930", "O44565", "WBGene00002247", "Q18823", "WBGene00016913", "Q19981", "WBGene00006432", "G5EG68", "WBGene00018304", "Q06561", "WBGene00006787", "G5ECE3", "WBGene00002248", "Q21313", "WBGene00001328" ] }, "reaction_10525220": { "compartment": "compartment_70101", "id": "reaction_10525220", "reactome": "R-CEL-446391", "name": "Formation of the PINCH-ILK-parvin complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10525214", "species_10524045", "species_10525212" ], "products": [ "species_10525218" ], "modifiers": [], "additional_components": [ "WBGene00003931", "P50464", "WBGene00006826", "Q19157", "WBGene00004030", "Q9TZC4", "WBGene00003931" ] }, "reaction_10523749": { "compartment": "compartment_70101", "id": "reaction_10523749", "reactome": "R-CEL-430341", "name": "Mig-2 recruits Migfilin to the cell-ECM adhesions", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10523740", "species_10523745" ], "products": [ "species_10523747" ], "modifiers": [], "additional_components": [ "WBGene00006999", "WBGene00006836", "Q18685", "WBGene00006836", "Q9U3F4", "WBGene00006999" ] }, "reaction_10524049": { "compartment": "compartment_70101", "id": "reaction_10524049", "reactome": "R-CEL-432897", "name": "ILK interacts with beta-1 integrin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10524045", "species_10514200" ], "products": [ "species_10524047" ], "modifiers": [], "additional_components": [ "WBGene00003931", "WBGene00003930", "Q27874", "WBGene00003930", "Q9TZC4", "WBGene00003931" ] }, "reaction_10523759": { "compartment": "compartment_70101", "id": "reaction_10523759", "reactome": "R-CEL-430347", "name": "MigFilin associates with Filamin and F-actin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10523740", "species_10523755", "species_10523753" ], "products": [ "species_10523757" ], "modifiers": [], "additional_components": [ "WBGene00006999", "P0DM41", "WBGene00000063", "P0DM42", "WBGene00000065", "P10984", "WBGene00000064", "P10986", "WBGene00000066", "species_29358", "U4PBJ9", "WBGene00022048", "D0VWL6", "WBGene00016006", "U4PBJ9", "WBGene00022048", "D0VWL6", "WBGene00016006", "P0DM41", "WBGene00000063", "P0DM42", "WBGene00000065", "P10984", "WBGene00000064", "P10986", "WBGene00000066", "species_29358", "Q9U3F4", "WBGene00006999" ] }, "reaction_10525199": { "compartment": "compartment_70101", "id": "reaction_10525199", "reactome": "R-CEL-446364", "name": "Migfilin interacts with VASP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10523740", "species_10525195" ], "products": [ "species_10525197" ], "modifiers": [], "additional_components": [ "WBGene00006999", "WBGene00006770", "G5EG53", "WBGene00006770", "Q9U3F4", "WBGene00006999" ] }, "reaction_10513001": { "compartment": "compartment_876", "id": "reaction_10513001", "reactome": "R-CEL-190519", "name": "Internalization of gap junction plaques", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10512942", "species_10512947" ], "products": [ "species_10512999" ], "modifiers": [], "additional_components": [ "A0A486WXX8", "WBGene00000894", "P35603", "WBGene00001082", "WBGene00002041", "U4PBY2", "WBGene00002041", "P35603", "WBGene00001082", "A0A486WXX8", "WBGene00000894" ] }, "reaction_10513003": { "compartment": "compartment_70101", "id": "reaction_10513003", "reactome": "R-CEL-190829", "name": "Lysosomal degradation of gap junction plaques", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10512999" ], "products": [], "modifiers": [], "additional_components": [ "U4PBY2", "WBGene00002041", "P35603", "WBGene00001082", "A0A486WXX8", "WBGene00000894" ] }, "reaction_10508138": { "compartment": "compartment_7660", "id": "reaction_10508138", "reactome": "R-CEL-77071", "name": "Phosphorylation (Ser5) of RNA pol II CTD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10508135" ], "products": [ "species_113582", "species_10508131" ], "modifiers": [ [ "species_10508135", "catalyst" ] ], "additional_components": [ "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529" ] }, "reaction_10509405": { "compartment": "compartment_7660", "id": "reaction_10509405", "reactome": "R-CEL-113430", "name": "Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508135" ], "products": [ "species_10508135" ], "modifiers": [], "additional_components": [ "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529" ] }, "reaction_10558214": { "compartment": "compartment_984", "id": "reaction_10558214", "reactome": "R-CEL-6786652", "name": "CHIT1 hydrolyses CHIT to 3xADGP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_6786654" ], "products": [ "species_6786660" ], "modifiers": [ [ "species_10558211", "catalyst" ] ], "additional_components": [ "WBGene00000503" ] }, "reaction_10512728": { "compartment": "compartment_984", "id": "reaction_10512728", "reactome": "R-CEL-189062", "name": "lactose + H2O => D-glucose + D-galactose", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_188973", "species_109276" ], "products": [ "species_70115", "species_188995" ], "modifiers": [ [ "species_10512725", "catalyst" ] ], "additional_components": [ "Q18758", "WBGene00016848" ] }, "reaction_10513005": { "compartment": "compartment_984", "id": "reaction_10513005", "reactome": "R-CEL-191114", "name": "Digestion of branched starch (amylopectin) by extracellular amylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_189071" ], "products": [ "species_191103", "species_188986", "species_189108" ], "modifiers": [ [ "species_10512715", "catalyst" ] ], "additional_components": [ "species_70113", "WBGene00008220" ] }, "reaction_10512718": { "compartment": "compartment_984", "id": "reaction_10512718", "reactome": "R-CEL-188979", "name": "Digestion of linear starch (amylose) by extracellular amylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_189075" ], "products": [ "species_191103", "species_188986" ], "modifiers": [ [ "species_10512715", "catalyst" ] ], "additional_components": [ "species_70113", "WBGene00008220" ] }, "reaction_10556729": { "compartment": "compartment_7660", "id": "reaction_10556729", "reactome": "R-CEL-5691001", "name": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30555", "species_10556726" ], "products": [ "species_113541", "species_10556722" ], "modifiers": [ [ "species_10556726", "catalyst" ] ], "additional_components": [ "Q95Y97", "WBGene00019767", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "P90829", "WBGene00008645", "Q19366", "WBGene00008722", "Q21730", "WBGene00011016", "O02115", "WBGene00003955", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "P34409", "WBGene00017696", "Q95Y97", "WBGene00019767", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "P90829", "WBGene00008645", "Q19366", "WBGene00008722", "Q21730", "WBGene00011016", "O02115", "WBGene00003955", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "P34409", "WBGene00017696", "Q95Y97", "WBGene00019767", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "P90829", "WBGene00008645", "Q19366", "WBGene00008722", "Q21730", "WBGene00011016", "O02115", "WBGene00003955", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "P34409", "WBGene00017696" ] }, "reaction_10556724": { "compartment": "compartment_7660", "id": "reaction_10556724", "reactome": "R-CEL-5691000", "name": "TFIIH binds GG-NER site to form a verification complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10556156", "species_10506316" ], "products": [ "species_10556158" ], "modifiers": [], "additional_components": [ "Q23457", "WBGene00004320", "Q17392", "WBGene00000839", "Q21554", "WBGene00010890", "P30644", "WBGene00011145", "Q23451", "WBGene00013924", "Q9N4C3", "WBGene00022296", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q23457", "WBGene00004320", "Q17392", "WBGene00000839", "Q21554", "WBGene00010890", "P30644", "WBGene00011145", "Q23451", "WBGene00013924", "Q9N4C3", "WBGene00022296", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725" ] }, "reaction_10556164": { "compartment": "compartment_7660", "id": "reaction_10556164", "reactome": "R-CEL-5689861", "name": "Recruitment of XPA and release of CAK ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10556158", "species_10556135" ], "products": [ "species_10506279", "species_10556162" ], "modifiers": [], "additional_components": [ "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q23457", "WBGene00004320", "Q17392", "WBGene00000839", "Q21554", "WBGene00010890", "P30644", "WBGene00011145", "Q23451", "WBGene00013924", "Q9N4C3", "WBGene00022296", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "WBGene00006963", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "K8F7X5", "WBGene00013529", "Q95PZ4", "WBGene00013441", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "P34567", "WBGene00011814", "Q9N3L2", "WBGene00021752", "Q21302", "WBGene00006963", "Q23457", "WBGene00004320", "Q17392", "WBGene00000839", "Q21554", "WBGene00010890", "P30644", "WBGene00011145", "Q23451", "WBGene00013924", "Q9N4C3", "WBGene00022296", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725" ] }, "reaction_10558516": { "compartment": "compartment_7660", "id": "reaction_10558516", "reactome": "R-CEL-6790454", "name": "SUMOylation of XPC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10556715", "species_10558502" ], "products": [ "species_10558511", "species_10546073" ], "modifiers": [ [ "species_10558513", "catalyst" ] ], "additional_components": [ "K8F7X5", "WBGene00013529", "Q95PZ4", "WBGene00013441", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "P34567", "WBGene00011814", "Q9N3L2", "WBGene00021752", "Q21302", "WBGene00006963", "Q23457", "WBGene00004320", "Q17392", "WBGene00000839", "Q21554", "WBGene00010890", "P30644", "WBGene00011145", "Q23451", "WBGene00013924", "Q9N4C3", "WBGene00022296", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "Q23457", "WBGene00004320", "Q17392", "WBGene00000839", "Q21554", "WBGene00010890", "K8F7X5", "WBGene00013529", "Q95PZ4", "WBGene00013441", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "P34567", "WBGene00011814", "Q9N3L2", "WBGene00021752", "Q21302", "WBGene00006963", "P30644", "WBGene00011145", "Q23451", "WBGene00013924", "P55853", "WBGene00004888", "Q9N4C3", "WBGene00022296", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "WBGene00006706" ] }, "reaction_10508629": { "compartment": "compartment_7660", "id": "reaction_10508629", "reactome": "R-CEL-109955", "name": "Formation of ERCC1:XPF heterodimeric complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508620", "species_10508625" ], "products": [ "species_10508627" ], "modifiers": [], "additional_components": [ "WBGene00008665", "WBGene00008140", "G5EBZ1", "WBGene00008140", "Q93456", "WBGene00008665" ] }, "reaction_10556718": { "compartment": "compartment_7660", "id": "reaction_10556718", "reactome": "R-CEL-5690996", "name": "ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10556711" ], "products": [ "species_113550", "species_113582", "species_10556715" ], "modifiers": [ [ "species_10556711", "catalyst" ] ], "additional_components": [ "K8F7X5", "WBGene00013529", "Q95PZ4", "WBGene00013441", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "P34567", "WBGene00011814", "Q9N3L2", "WBGene00021752", "Q21302", "WBGene00006963", "Q23457", "WBGene00004320", "Q17392", "WBGene00000839", "Q21554", "WBGene00010890", "P30644", "WBGene00011145", "Q23451", "WBGene00013924", "Q9N4C3", "WBGene00022296", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "K8F7X5", "WBGene00013529", "Q95PZ4", "WBGene00013441", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "P34567", "WBGene00011814", "Q9N3L2", "WBGene00021752", "Q21302", "WBGene00006963", "Q23457", "WBGene00004320", "Q17392", "WBGene00000839", "Q21554", "WBGene00010890", "P30644", "WBGene00011145", "Q23451", "WBGene00013924", "Q9N4C3", "WBGene00022296", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "K8F7X5", "WBGene00013529", "Q95PZ4", "WBGene00013441", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "P34567", "WBGene00011814", "Q9N3L2", "WBGene00021752", "Q21302", "WBGene00006963", "Q23457", "WBGene00004320", "Q17392", "WBGene00000839", "Q21554", "WBGene00010890", "P30644", "WBGene00011145", "Q23451", "WBGene00013924", "Q9N4C3", "WBGene00022296", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725" ] }, "reaction_10544211": { "compartment": "compartment_984", "id": "reaction_10544211", "reactome": "R-CEL-2424243", "name": "SPARC binds Collagen type I fibril, hydroxylapatite and Ca2+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2672070", "species_10509625", "species_10526518", "species_74112" ], "products": [ "species_10544209" ], "modifiers": [], "additional_components": [ "Q9N4U2", "WBGene00000647", "WBGene00003893", "species_74016", "P34714", "WBGene00003893", "Q9N4U2", "WBGene00000647", "species_2672070" ] }, "reaction_10544420": { "compartment": "compartment_984", "id": "reaction_10544420", "reactome": "R-CEL-2467665", "name": "AGRN binds Beta amyloid fibril via GAG chains", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10544412", "species_10544416" ], "products": [ "species_10544418" ], "modifiers": [], "additional_components": [ "Q10651", "WBGene00000149", "Q10651", "WBGene00000149", "P34710", "unc-6" ] }, "reaction_10545273": { "compartment": "compartment_876", "id": "reaction_10545273", "reactome": "R-CEL-2681667", "name": "TNC binds Integrin alphaVbeta3, alphaVbeta6, alpha2beta1, alpha7beta1, alpha8beta1, alpha9beta1, alphaXbeta1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10517415", "species_10545269" ], "products": [ "species_10545271" ], "modifiers": [], "additional_components": [ "Q18096", "WBGene00007687", "P34446", "WBGene00003929", "Q27874", "WBGene00003930", "Q03600", "WBGene00002081", "P34446", "WBGene00003929", "Q27874", "WBGene00003930", "Q03600", "WBGene00002081", "Q18096", "WBGene00007687" ] }, "reaction_10545277": { "compartment": "compartment_984", "id": "reaction_10545277", "reactome": "R-CEL-2681681", "name": "Tenascins C, R, (X, N) bind fibronectin matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10544239", "species_10517394" ], "products": [ "species_10545275" ], "modifiers": [], "additional_components": [ "Q18096", "WBGene00007687", "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769", "Q18096", "WBGene00007687" ] }, "reaction_10557840": { "compartment": "compartment_7660", "id": "reaction_10557840", "reactome": "R-CEL-6781818", "name": "RNA Pol II initiates transcription from damaged DNA template", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10504431", "species_10506316", "species_5688114" ], "products": [ "species_10557838" ], "modifiers": [], "additional_components": [ "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529" ] }, "reaction_10557845": { "compartment": "compartment_7660", "id": "reaction_10557845", "reactome": "R-CEL-6781824", "name": "Active RNA Pol II complex transcribes lesion-containing DNA template", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10557838", "species_6781829" ], "products": [ "species_113541", "species_10557842" ], "modifiers": [ [ "species_10557838", "catalyst" ] ], "additional_components": [ "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529" ] }, "reaction_10557865": { "compartment": "compartment_7660", "id": "reaction_10557865", "reactome": "R-CEL-6781833", "name": "ERCC8 (CSA) binds stalled RNA Pol II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10557852", "species_10557861" ], "products": [ "species_10557863", "species_10556775" ], "modifiers": [], "additional_components": [ "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q86D18", "WBGene00010011", "Q18963", "WBGene00008403", "Q21554", "WBGene00010890", "Q23457", "WBGene00004320", "Q17392", "WBGene00000839", "Q9GS00", "WBGene00000813", "Q9N359", "WBGene00000816", "P91001", "WBGene00000817", "O01422", "WBGene00000814", "Q9N425", "WBGene00000815", "Q95PZ0", "WBGene00000818", "Q18963", "WBGene00008403", "Q21554", "WBGene00010890", "Q23457", "WBGene00004320", "Q17392", "WBGene00000839", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q86D18", "WBGene00010011", "Q9GS00", "WBGene00000813", "Q9N359", "WBGene00000816", "P91001", "WBGene00000817", "O01422", "WBGene00000814", "Q9N425", "WBGene00000815", "Q95PZ0", "WBGene00000818" ] }, "reaction_10557913": { "compartment": "compartment_7660", "id": "reaction_10557913", "reactome": "R-CEL-6782069", "name": "UVSSA:USP7 deubiquitinates ERCC6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10557904" ], "products": [ "species_10502318", "species_10557910" ], "modifiers": [ [ "species_10557904", "catalyst" ] ], "additional_components": [ "Q23088", "WBGene00022812", "Q7JKC3", "WBGene00010406", "P34545", "WBGene00000366", "Q21302", "WBGene00006963", "H2KYV0", "WBGene00016115", "P52652", "WBGene00012000", "Q18963", "WBGene00008403", "Q21554", "WBGene00010890", "Q23457", "WBGene00004320", "Q17392", "WBGene00000839", "Q19826", "WBGene00017830", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "O02092", "WBGene00018391", "Q9GR61", "WBGene00021347", "Q9N3C9", "WBGene00021845", "Q93338", "WBGene00007971", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q86D18", "WBGene00010011", "Q10051", "WBGene00020423", "Q20716", "WBGene00009966", "Q9U1Q7", "WBGene00001258", "Q9U2S6", "WBGene00000889", "P52009", "WBGene00000877", "P52016", "WBGene00000884", "P91175", "WBGene00016837", "Q22139", "WBGene00011411", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "Q23088", "WBGene00022812", "Q7JKC3", "WBGene00010406", "P34545", "WBGene00000366", "Q18963", "WBGene00008403", "Q21554", "WBGene00010890", "Q23457", "WBGene00004320", "Q17392", "WBGene00000839", "Q19826", "WBGene00017830", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "O02092", "WBGene00018391", "Q9GR61", "WBGene00021347", "Q9N3C9", "WBGene00021845", "Q93338", "WBGene00007971", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q86D18", "WBGene00010011", "Q21302", "WBGene00006963", "H2KYV0", "WBGene00016115", "P52652", "WBGene00012000", "Q10051", "WBGene00020423", "Q20716", "WBGene00009966", "Q9U1Q7", "WBGene00001258", "Q9U2S6", "WBGene00000889", "P52009", "WBGene00000877", "P52016", "WBGene00000884", "P91175", "WBGene00016837", "Q22139", "WBGene00011411", "Q23088", "WBGene00022812", "Q7JKC3", "WBGene00010406", "P34545", "WBGene00000366", "Q21302", "WBGene00006963", "H2KYV0", "WBGene00016115", "P52652", "WBGene00012000", "Q18963", "WBGene00008403", "Q21554", "WBGene00010890", "Q23457", "WBGene00004320", "Q17392", "WBGene00000839", "Q19826", "WBGene00017830", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "O02092", "WBGene00018391", "Q9GR61", "WBGene00021347", "Q9N3C9", "WBGene00021845", "Q93338", "WBGene00007971", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q86D18", "WBGene00010011", "Q10051", "WBGene00020423", "Q20716", "WBGene00009966", "Q9U1Q7", "WBGene00001258", "Q9U2S6", "WBGene00000889", "P52009", "WBGene00000877", "P52016", "WBGene00000884", "P91175", "WBGene00016837", "Q22139", "WBGene00011411" ] }, "reaction_10557867": { "compartment": "compartment_7660", "id": "reaction_10557867", "reactome": "R-CEL-6781840", "name": "ERCC6 binds stalled RNA Pol II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10557850", "species_10557842" ], "products": [ "species_10557852" ], "modifiers": [], "additional_components": [ "WBGene00010011", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q86D18", "WBGene00010011" ] }, "reaction_10557886": { "compartment": "compartment_7660", "id": "reaction_10557886", "reactome": "R-CEL-6781867", "name": "ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502318", "species_10557863" ], "products": [ "species_10557883" ], "modifiers": [ [ "species_10557863", "catalyst" ] ], "additional_components": [ "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "Q18963", "WBGene00008403", "Q21554", "WBGene00010890", "Q23457", "WBGene00004320", "Q17392", "WBGene00000839", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q86D18", "WBGene00010011", "Q18963", "WBGene00008403", "Q21554", "WBGene00010890", "Q23457", "WBGene00004320", "Q17392", "WBGene00000839", "Q19826", "WBGene00017830", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "O02092", "WBGene00018391", "Q9GR61", "WBGene00021347", "Q9N3C9", "WBGene00021845", "Q93338", "WBGene00007971", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q86D18", "WBGene00010011", "Q18963", "WBGene00008403", "Q21554", "WBGene00010890", "Q23457", "WBGene00004320", "Q17392", "WBGene00000839", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q86D18", "WBGene00010011" ] }, "reaction_10543938": { "compartment": "compartment_876", "id": "reaction_10543938", "reactome": "R-CEL-2327746", "name": "FN1 aggregation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10515311", "species_10515319" ], "products": [ "species_10543936" ], "modifiers": [], "additional_components": [ "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769", "P34446", "WBGene00003929", "Q27874", "WBGene00003930", "species_266099", "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769", "P34446", "WBGene00003929", "Q27874", "WBGene00003930" ] }, "reaction_10544859": { "compartment": "compartment_984", "id": "reaction_10544859", "reactome": "R-CEL-2545196", "name": "FN1 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10515311" ], "products": [ "species_10515313" ], "modifiers": [], "additional_components": [ "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769" ] }, "reaction_10564552": { "compartment": "compartment_20699", "id": "reaction_10564552", "reactome": "R-CEL-8847637", "name": "NSF and SNAPs bind the cis-SNARE at the Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10564548", "species_10557329", "species_10557345" ], "products": [ "species_10564550" ], "modifiers": [], "additional_components": [ "Q9TXZ9", "WBGene00015164", "Q20797", "WBGene00006373", "Q95ZW1", "WBGene00017273", "Q94392", "WBGene00003818", "Q18921", "WBGene00017016", "Q94392", "WBGene00003818", "Q18921", "WBGene00017016", "Q9TXZ9", "WBGene00015164", "Q20797", "WBGene00006373", "Q95ZW1", "WBGene00017273" ] }, "reaction_10564571": { "compartment": "compartment_20699", "id": "reaction_10564571", "reactome": "R-CEL-8847887", "name": "RAB33B:GTP binds RIC1:RGP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10564567", "species_10564561" ], "products": [ "species_10564569" ], "modifiers": [], "additional_components": [ "Q7YWW8", "WBGene00010815", "Q09417", "WBGene00011071", "Q20365", "WBGene00004283", "species_29438", "Q20365", "WBGene00004283", "species_29438", "Q7YWW8", "WBGene00010815", "Q09417", "WBGene00011071" ] }, "reaction_10564079": { "compartment": "compartment_20699", "id": "reaction_10564079", "reactome": "R-CEL-6811433", "name": "The COG tethering complex interacts with numerous SNAREs at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10563498", "species_10564075" ], "products": [ "species_10564077" ], "modifiers": [], "additional_components": [ "Q21270", "WBGene00019481", "Q6AW08", "WBGene00022121", "Q95XZ0", "WBGene00021784", "G5EE66", "WBGene00003258", "O44502", "WBGene00019820", "Q21444", "WBGene00000585", "P91151", "WBGene00016608", "Q9TY08", "WBGene00022534", "Q95ZW1", "WBGene00017273", "P41941", "WBGene00007128", "O18230", "WBGene00013302", "Q20797", "WBGene00006373", "H2KYN0", "WBGene00016643", "P83351", "WBGene00019305", "Q9TY08", "WBGene00022534", "Q95ZW1", "WBGene00017273", "P41941", "WBGene00007128", "O18230", "WBGene00013302", "Q20797", "WBGene00006373", "H2KYN0", "WBGene00016643", "P83351", "WBGene00019305", "Q21270", "WBGene00019481", "Q6AW08", "WBGene00022121", "Q95XZ0", "WBGene00021784", "G5EE66", "WBGene00003258", "O44502", "WBGene00019820", "Q21444", "WBGene00000585", "P91151", "WBGene00016608" ] }, "reaction_10564958": { "compartment": "compartment_20699", "id": "reaction_10564958", "reactome": "R-CEL-8849748", "name": "The COG complex binds RABs at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10564954", "species_10563498" ], "products": [ "species_10564956" ], "modifiers": [], "additional_components": [ "species_29438", "Q18969", "WBGene00004286", "Q9XWZ3", "WBGene00004282", "P34213", "WBGene00004269", "Q22782", "WBGene00004270", "Q21270", "WBGene00019481", "Q6AW08", "WBGene00022121", "Q95XZ0", "WBGene00021784", "G5EE66", "WBGene00003258", "O44502", "WBGene00019820", "Q21444", "WBGene00000585", "P91151", "WBGene00016608", "Q21270", "WBGene00019481", "Q6AW08", "WBGene00022121", "Q95XZ0", "WBGene00021784", "G5EE66", "WBGene00003258", "O44502", "WBGene00019820", "Q21444", "WBGene00000585", "P91151", "WBGene00016608", "species_29438", "Q18969", "WBGene00004286", "Q9XWZ3", "WBGene00004282", "P34213", "WBGene00004269", "Q22782", "WBGene00004270" ] }, "reaction_10543921": { "compartment": "compartment_984", "id": "reaction_10543921", "reactome": "R-CEL-2327733", "name": "FN1 binds Collagen types I-V, VII", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10515311", "species_10543917" ], "products": [ "species_10543919" ], "modifiers": [], "additional_components": [ "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769", "Q9N4U2", "WBGene00000647", "O76368", "WBGene00000674", "Q09457", "WBGene00000251", "P17140", "WBGene00002280", "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689", "Q9N4U2", "WBGene00000647", "O76368", "WBGene00000674", "Q09457", "WBGene00000251", "P17140", "WBGene00002280", "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689", "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769" ] } }, "collapsed_reaction_dictionary": { "reaction_10509451": { "compartment": "compartment_17906", "id": "reaction_10509451", "reactome": "R-CEL-114284", "name": "Release of Cytochrome c from mitochondria", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509449" ], "products": [ "species_10509434" ], "modifiers": [], "additional_components": [ "P19974", "WBGene00017121", "Q23240", "WBGene00013854", "P19974", "WBGene00017121", "Q23240", "WBGene00013854" ] }, "reaction_10554208": { "compartment": "compartment_7660", "id": "reaction_10554208", "reactome": "R-CEL-5651805", "name": "LIG1 bound to APEX1 and PCNA ligates SSB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508820" ], "products": [ "species_10554205" ], "modifiers": [ [ "species_10508820", "catalyst" ] ], "additional_components": [ "G5EBR7", "WBGene00001372", "Q95Y97", "WBGene00019767", "P90829", "WBGene00008645", "Q19366", "WBGene00008722", "Q21730", "WBGene00011016", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "O02115", "WBGene00003955", "Q27474", "WBGene00002985", "G5EBR7", "WBGene00001372", "Q95Y97", "WBGene00019767", "P90829", "WBGene00008645", "Q19366", "WBGene00008722", "Q21730", "WBGene00011016", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "O02115", "WBGene00003955", "Q27474", "WBGene00002985", "G5EBR7", "WBGene00001372", "Q95Y97", "WBGene00019767", "P90829", "WBGene00008645", "Q19366", "WBGene00008722", "Q21730", "WBGene00011016", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "O02115", "WBGene00003955", "Q27474", "WBGene00002985" ] }, "reaction_10508822": { "compartment": "compartment_7660", "id": "reaction_10508822", "reactome": "R-CEL-110371", "name": "LIG1 binds APEX1 and PCNA at SSB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502732", "species_10508818" ], "products": [ "species_10508820" ], "modifiers": [], "additional_components": [ "WBGene00002985", "G5EBR7", "WBGene00001372", "Q95Y97", "WBGene00019767", "P90829", "WBGene00008645", "Q19366", "WBGene00008722", "Q21730", "WBGene00011016", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "O02115", "WBGene00003955", "G5EBR7", "WBGene00001372", "Q95Y97", "WBGene00019767", "P90829", "WBGene00008645", "Q19366", "WBGene00008722", "Q21730", "WBGene00011016", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "O02115", "WBGene00003955", "Q27474", "WBGene00002985" ] }, "reaction_10508814": { "compartment": "compartment_7660", "id": "reaction_10508814", "reactome": "R-CEL-110368", "name": "POLD,POLE-mediated DNA strand displacement synthesis", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30555", "species_10508811" ], "products": [ "species_10508807", "species_113541" ], "modifiers": [ [ "species_10508811", "catalyst" ] ], "additional_components": [ "G5EBR7", "WBGene00001372", "Q95Y97", "WBGene00019767", "P90829", "WBGene00008645", "Q19366", "WBGene00008722", "Q21730", "WBGene00011016", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "O02115", "WBGene00003955", "Q9N3T2", "WBGene00000794", "G5EBR7", "WBGene00001372", "Q95Y97", "WBGene00019767", "P90829", "WBGene00008645", "Q19366", "WBGene00008722", "Q21730", "WBGene00011016", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "O02115", "WBGene00003955", "Q9N3T2", "WBGene00000794", "G5EBR7", "WBGene00001372", "Q95Y97", "WBGene00019767", "P90829", "WBGene00008645", "Q19366", "WBGene00008722", "Q21730", "WBGene00011016", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "O02115", "WBGene00003955", "Q9N3T2", "WBGene00000794" ] }, "reaction_10546996": { "compartment": "compartment_70101", "id": "reaction_10546996", "reactome": "R-CEL-3249379", "name": "p-S407-STAT6 is phosphorylated at Tyr641", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10546994" ], "products": [ "species_10546974", "species_29370" ], "modifiers": [], "additional_components": [ "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111" ] }, "reaction_10546986": { "compartment": "compartment_70101", "id": "reaction_10546986", "reactome": "R-CEL-3249370", "name": "p-S407,Y641-STAT6 dimer migrates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546976" ], "products": [ "species_10546984" ], "modifiers": [], "additional_components": [ "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111" ] }, "reaction_10546988": { "compartment": "compartment_70101", "id": "reaction_10546988", "reactome": "R-CEL-3249372", "name": "p-S407,Y641-STAT6 is dimerized", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546974" ], "products": [ "species_10546976" ], "modifiers": [], "additional_components": [ "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111" ] }, "reaction_10567345": { "compartment": "compartment_70101", "id": "reaction_10567345", "reactome": "R-CEL-8875576", "name": "CRK,CRKL recruits RAC1 GEF to activated MET", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10567341", "species_10567330" ], "products": [ "species_10567343" ], "modifiers": [], "additional_components": [ "G5EDJ4", "WBGene00004928", "Q9XVQ7", "WBGene00008711", "P29355", "WBGene00004774", "Q9NHC3", "WBGene00000416", "Q95XA9", "WBGene00021238", "G5EDJ4", "WBGene00004928", "Q9XVQ7", "WBGene00008711", "P29355", "WBGene00004774", "Q9NHC3", "WBGene00000416", "Q95XA9", "WBGene00021238" ] }, "reaction_10567332": { "compartment": "compartment_70101", "id": "reaction_10567332", "reactome": "R-CEL-8875540", "name": "GAB1 recruits CRK,CRKL to MET", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10520269", "species_10543879" ], "products": [ "species_10567330" ], "modifiers": [], "additional_components": [ "Q9NHC3", "WBGene00000416", "Q95XA9", "WBGene00021238", "G5EDJ4", "WBGene00004928", "Q9XVQ7", "WBGene00008711", "P29355", "WBGene00004774", "G5EDJ4", "WBGene00004928", "Q9XVQ7", "WBGene00008711", "P29355", "WBGene00004774", "Q9NHC3", "WBGene00000416", "Q95XA9", "WBGene00021238" ] }, "reaction_10567348": { "compartment": "compartment_70101", "id": "reaction_10567348", "reactome": "R-CEL-8875591", "name": "DOCK7 activates RAC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10541992" ], "products": [ "species_29420", "species_10509457" ], "modifiers": [ [ "species_10567343", "catalyst" ] ], "additional_components": [ "species_29420", "Q03206", "ced-10", "species_29438", "Q03206", "ced-10", "G5EDJ4", "WBGene00004928", "Q9XVQ7", "WBGene00008711", "P29355", "WBGene00004774", "Q9NHC3", "WBGene00000416", "Q95XA9", "WBGene00021238" ] }, "reaction_10567336": { "compartment": "compartment_70101", "id": "reaction_10567336", "reactome": "R-CEL-8875558", "name": "RAPGEF1 binds CRK,CRKL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10567330", "species_10528529" ], "products": [ "species_10567334" ], "modifiers": [], "additional_components": [ "G5EDJ4", "WBGene00004928", "Q9XVQ7", "WBGene00008711", "P29355", "WBGene00004774", "Q9NHC3", "WBGene00000416", "Q95XA9", "WBGene00021238", "WBGene00021320", "H2KZX7", "WBGene00021320", "G5EDJ4", "WBGene00004928", "Q9XVQ7", "WBGene00008711", "P29355", "WBGene00004774", "Q9NHC3", "WBGene00000416", "Q95XA9", "WBGene00021238" ] }, "reaction_10567339": { "compartment": "compartment_876", "id": "reaction_10567339", "reactome": "R-CEL-8875568", "name": "RAPGEF1 activates RAP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10518265" ], "products": [ "species_29420", "species_10518164" ], "modifiers": [ [ "species_10567334", "catalyst" ] ], "additional_components": [ "Q18246", "WBGene00004307", "species_29420", "Q18246", "WBGene00004307", "species_29438", "H2KZX7", "WBGene00021320", "G5EDJ4", "WBGene00004928", "Q9XVQ7", "WBGene00008711", "P29355", "WBGene00004774", "Q9NHC3", "WBGene00000416", "Q95XA9", "WBGene00021238" ] }, "reaction_10502772": { "compartment": "compartment_7660", "id": "reaction_10502772", "reactome": "R-CEL-69562", "name": "Inactivation of Cyclin E:Cdk2 complexes by p27/p21", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502767", "species_10502749" ], "products": [ "species_10502769" ], "modifiers": [ [ "species_10502767", "catalyst" ] ], "additional_components": [ "WBGene00000517", "O61847", "WBGene00019362", "O61847", "WBGene00019362", "G5EEJ2", "WBGene00000517", "WBGene00000517" ] }, "reaction_10517476": { "compartment": "compartment_70101", "id": "reaction_10517476", "reactome": "R-CEL-264444", "name": "Autoubiquitination of phospho-COP1(Ser-387 )", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10517469", "species_10502375" ], "products": [ "species_10517473" ], "modifiers": [ [ "species_10517469", "catalyst" ] ], "additional_components": [ "WBGene00003917", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "Q965F9", "WBGene00003917", "WBGene00003917" ] }, "reaction_10517478": { "compartment": "compartment_70101", "id": "reaction_10517478", "reactome": "R-CEL-264458", "name": "Proteasome mediated degradation of COP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10517473" ], "products": [ "species_10502375" ], "modifiers": [ [ "species_10502572", "catalyst" ] ], "additional_components": [ "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "Q965F9", "WBGene00003917", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "P91477", "WBGene00003950", "Q95PZ7", "WBGene00013435", "Q18115", "WBGene00004459", "O62102", "WBGene00003948", "O17071", "WBGene00004504", "Q10920", "WBGene00016623", "P34286", "WBGene00003952", "Q9XTT9", "WBGene00004506", "Q23449", "WBGene00004468", "Q95005", "WBGene00003925", "P46502", "WBGene00004503", "O61792", "WBGene00004464", "O17586", "WBGene00003922", "O76371", "WBGene00004505", "Q20585", "WBGene00004463", "Q95008", "WBGene00003926", "Q18787", "WBGene00004501", "Q20058", "WBGene00009445", "Q9N599", "WBGene00003924", "O16368", "WBGene00004502", "O61742", "WBGene00004466", "Q09583", "WBGene00003928", "Q966I8", "WBGene00003947", "Q04908", "WBGene00004460", "Q9XUV0", "WBGene00003951", "Q27488", "WBGene00003923", "Q9GZH5", "WBGene00004458", "O44156", "WBGene00003927", "Q22253", "WBGene00004465", "O76577", "WBGene00004467", "P90868", "WBGene00003953", "Q19324", "WBGene00004461", "Q17971", "WBGene00007588", "Q23237", "WBGene00003949", "Q20938", "WBGene00004462" ] }, "reaction_10517471": { "compartment": "compartment_13231", "id": "reaction_10517471", "reactome": "R-CEL-264418", "name": "Translocation of COP1 from the nucleus to the cytoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10517467" ], "products": [ "species_10517469" ], "modifiers": [], "additional_components": [ "WBGene00003917", "WBGene00003917" ] }, "reaction_10512670": { "compartment": "compartment_7660", "id": "reaction_10512670", "reactome": "R-CEL-187934", "name": "Inactivation of Cyclin A:Cdk2 complexes by p27/p21", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502767", "species_10511613" ], "products": [ "species_10512663" ], "modifiers": [ [ "species_10502767", "catalyst" ] ], "additional_components": [ "WBGene00000517", "O61847", "WBGene00019362", "O61847", "WBGene00019362", "G5EEJ2", "WBGene00000517", "WBGene00000517" ] }, "reaction_10552354": { "compartment": "compartment_984", "id": "reaction_10552354", "reactome": "R-CEL-5433072", "name": "GGTs hydrolyse glutamate from AFXBO-SG, AFNBO-SG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5490253", "species_109276" ], "products": [ "species_210382", "species_5490235" ], "modifiers": [ [ "species_10552351", "catalyst" ] ], "additional_components": [ "CHEBI:78581", "CHEBI:78587", "CHEBI:78579", "CHEBI:78584", "H2L0B7", "WBGene00020590", "O18256", "WBGene00020590", "Q9N5V4", "WBGene00020590", "A0A486WVP7", "WBGene00020590", "B5BM47", "WBGene00020590" ] }, "reaction_10552364": { "compartment": "compartment_70101", "id": "reaction_10552364", "reactome": "R-CEL-5433074", "name": "ACY1:Zn2+ dimer hydrolyses mercapturic acids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5490236", "species_29356" ], "products": [ "species_2022890", "species_5490231" ], "modifiers": [ [ "species_10552361", "catalyst" ] ], "additional_components": [ "CHEBI:78580", "CHEBI:78585", "CHEBI:78583", "CHEBI:78578", "species_216785", "Q5WRS4", "WBGene00015509" ] }, "reaction_10525168": { "compartment": "compartment_12045", "id": "reaction_10525168", "reactome": "R-CEL-446214", "name": "Synthesis of dolichyl-phosphate-glucose", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449299", "species_29410" ], "products": [ "species_532214", "species_110096" ], "modifiers": [ [ "species_10525165", "catalyst" ] ], "additional_components": [ "WBGene00019276" ] }, "reaction_10563798": { "compartment": "compartment_70101", "id": "reaction_10563798", "reactome": "R-CEL-6810464", "name": "NUDT14 hydrolyses UDP-Glc to G1P and UMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_29410" ], "products": [ "species_29548", "species_109402" ], "modifiers": [ [ "species_10563795", "catalyst" ] ], "additional_components": [ "WBGene00008238" ] }, "reaction_10529329": { "compartment": "compartment_70101", "id": "reaction_10529329", "reactome": "R-CEL-927889", "name": "SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10529324", "species_113592" ], "products": [ "species_10529326", "species_29370" ], "modifiers": [ [ "species_10529324", "catalyst" ] ], "additional_components": [ "P91914", "WBGene00004441", "Q19869", "WBGene00004440", "O01868", "WBGene00004436", "P48162", "WBGene00004438", "P52819", "WBGene00004434", "P48158", "WBGene00004435", "Q09533", "WBGene00004421", "P34334", "WBGene00004433", "O02639", "WBGene00004431", "Q95Y90", "WBGene00004420", "O44480", "WBGene00004432", "Q22716", "WBGene00004446", "Q9U332", "WBGene00004445", "Q9XWS4", "WBGene00004444", "P52814", "WBGene00004453", "O45226", "WBGene00004443", "Q21930", "WBGene00004442", "P48166", "WBGene00004454", "Q9BKU5", "WBGene00021350", "P50880", "WBGene00004414", "P61866", "WBGene00004424", "O17570", "WBGene00004452", "Q19162", "WBGene00004423", "Q9U2A8", "WBGene00004456", "Q9N4I4", "WBGene00004412", "O62388", "WBGene00012179", "O01504", 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"reaction_10529308": { "compartment": "compartment_70101", "id": "reaction_10529308", "reactome": "R-CEL-927836", "name": "SMG6 hydrolyzes mRNA with premature termination codon", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10529305" ], "products": [ "species_10529290" ], "modifiers": [ [ "species_10529305", "catalyst" ] ], "additional_components": [ "Q8WQF3", "WBGene00004882", "O76512", "WBGene00004880", "P91914", "WBGene00004441", "Q19869", "WBGene00004440", "O01868", "WBGene00004436", "P48162", "WBGene00004438", "P52819", "WBGene00004434", "P48158", "WBGene00004435", "Q09533", "WBGene00004421", "P34334", "WBGene00004433", "O02639", "WBGene00004431", "Q95Y90", "WBGene00004420", "O44480", "WBGene00004432", "Q22716", "WBGene00004446", "Q9U332", "WBGene00004445", "Q9XWS4", "WBGene00004444", "P52814", "WBGene00004453", "O45226", "WBGene00004443", "Q21930", "WBGene00004442", "P48166", "WBGene00004454", "Q9BKU5", "WBGene00021350", "P50880", "WBGene00004414", "P61866", "WBGene00004424", "O17570", "WBGene00004452", "Q19162", "WBGene00004423", "Q9U2A8", "WBGene00004456", "Q9N4I4", "WBGene00004412", "O62388", 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"WBGene00004484", "Q95Y04", "WBGene00004497", "Q22054", "WBGene00004485", "P90983", "WBGene00004498", "O01692", "WBGene00004486", "P48152", "WBGene00004472", "O18240", "WBGene00004487", "O18650", "WBGene00004488", "P48154", "WBGene00004470", "O17218", "WBGene00004491", "P49041", "WBGene00004474", "C2BR97", "WBGene00004881", "G5EDE4", "WBGene00012343", "Q21832", "WBGene00004387", "P49029", "WBGene00003123", "Q9BL61", "WBGene00022029", "Q21155", "WBGene00004388", "O45622", "WBGene00010405", "species_29420", "A0A486WX07", "WBGene00002066", "Q9U302", "WBGene00003902", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "O16520", "WBGene00020269", "Q09543", "WBGene00003901", "G5EDR3", "WBGene00006352", "G5EGK8", "WBGene00002363", "Q9BL68", "WBGene00004884" ] }, "reaction_10572480": { "compartment": "compartment_70101", "id": "reaction_10572480", "reactome": "R-CEL-9641096", "name": "Misfolded proteins bind PRKN:UBE2N:UBE2V1:Ub", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10572476", "species_10572472" ], "products": [ "species_10572478" ], "modifiers": [], "additional_components": [ "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "Q95XX0", "WBGene00006708", "O45495", "WBGene00006730", "G5ED37", "WBGene00003885", "H2L0N8", "WBGene00021349", "P30644", "WBGene00011145", "P90994", "WBGene00015184", "G5ED37", "WBGene00003885", "H2L0N8", "WBGene00021349", "P30644", "WBGene00011145", "P90994", "WBGene00015184", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "Q95XX0", "WBGene00006708", "O45495", "WBGene00006730" ] }, "reaction_10572551": { "compartment": "compartment_70101", "id": "reaction_10572551", "reactome": "R-CEL-9646348", "name": "PolyUb-Misfolded Proteins:HDAC6 bind dynein motor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10572547", "species_10552960" ], "products": [ "species_10572549" ], "modifiers": [], "additional_components": [ "P90994", "WBGene00015184", "H2L0N8", "WBGene00021349", "P30644", "WBGene00011145", "G5ED37", "WBGene00003885", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "Q19625", "WBGene00003412", "Q95QV2", "WBGene00000477", "Q20296", "WBGene00018319", "Q19020", "WBGene00000962", "O45087", "WBGene00015927", "Q65XS9", "WBGene00043067", "A0AAC1", "WBGene00012424", "Q7YTJ8", "WBGene00012425", "Q21557", "WBGene00010888", "Q22799", "WBGene00001005", "G5ED34", "WBGene00001007", "Q19020", "WBGene00000962", "O45087", "WBGene00015927", "Q65XS9", "WBGene00043067", "A0AAC1", "WBGene00012424", "Q7YTJ8", "WBGene00012425", "Q21557", "WBGene00010888", "Q22799", "WBGene00001005", "G5ED34", "WBGene00001007", "P90994", "WBGene00015184", "H2L0N8", "WBGene00021349", "P30644", "WBGene00011145", "G5ED37", "WBGene00003885", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "Q19625", "WBGene00003412", "Q95QV2", "WBGene00000477", "Q20296", "WBGene00018319" ] }, "reaction_10572520": { "compartment": "compartment_70101", "id": "reaction_10572520", "reactome": "R-CEL-9641111", "name": "Parkin transfers Ub to misfolded proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10572478" ], "products": [ "species_10572518" ], "modifiers": [], "additional_components": [ "G5ED37", "WBGene00003885", "H2L0N8", "WBGene00021349", "P30644", "WBGene00011145", "P90994", "WBGene00015184", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "Q95XX0", "WBGene00006708", "O45495", "WBGene00006730", "Q95XX0", "WBGene00006708", "O45495", "WBGene00006730", "P90994", "WBGene00015184", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "Q19625", "WBGene00003412", "Q95QV2", "WBGene00000477", "H2L0N8", "WBGene00021349", "P30644", "WBGene00011145", "G5ED37", "WBGene00003885" ] }, "reaction_10572522": { "compartment": "compartment_70101", "id": "reaction_10572522", "reactome": "R-CEL-9641127", "name": "Ub:misfolded proteins polymerize to PolyUb:misfolded proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10572518" ], "products": [ "species_10572500" ], "modifiers": [], "additional_components": [ "Q95XX0", "WBGene00006708", "O45495", "WBGene00006730", "P90994", "WBGene00015184", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "Q19625", "WBGene00003412", "Q95QV2", "WBGene00000477", "H2L0N8", "WBGene00021349", "P30644", "WBGene00011145", "G5ED37", "WBGene00003885", "Q95XX0", "WBGene00006708", "O45495", "WBGene00006730", "P90994", "WBGene00015184", "H2L0N8", "WBGene00021349", "P30644", "WBGene00011145", "G5ED37", "WBGene00003885", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "Q19625", "WBGene00003412", "Q95QV2", "WBGene00000477" ] }, "reaction_10550384": { "compartment": "compartment_70101", "id": "reaction_10550384", "reactome": "R-CEL-5205649", "name": "p62 links damaged mitochondria to LC3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10550378", "species_10550373" ], "products": [ "species_10550382" ], "modifiers": [], "additional_components": [ "WBGene00002981", "Q23424", "WBGene00001509", "Q17746", "WBGene00015552", "Q18746", "WBGene00008236", "Q21752", "WBGene00019900", "Q23424", "WBGene00001509", "Q17746", "WBGene00015552", "Q18746", "WBGene00008236", "Q21752", "WBGene00019900", "Q23536", "WBGene00002981" ] }, "reaction_10550417": { "compartment": "compartment_17927", "id": "reaction_10550417", "reactome": "R-CEL-5205681", "name": "Pink1 is cleaved on healthy mitochondria", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10550393" ], "products": [ "species_10550415" ], "modifiers": [], "additional_components": [ "WBGene00017137", "WBGene00017137" ] }, "reaction_10550409": { "compartment": "compartment_21994", "id": "reaction_10550409", "reactome": "R-CEL-5205663", "name": "LC3 binds the autophagosome membrane Atg5-Atg12 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10550382", "species_10550405" ], "products": [ "species_10550407" ], "modifiers": [], "additional_components": [ "Q23424", "WBGene00001509", "Q17746", "WBGene00015552", "Q18746", "WBGene00008236", "Q21752", "WBGene00019900", "Q23536", "WBGene00002981", "Q3V5I7", "WBGene00022152", "Q10931", "WBGene00002982", "Q3V5I7", "WBGene00022152", "Q10931", "WBGene00002982", "Q23424", "WBGene00001509", "Q17746", "WBGene00015552", "Q18746", "WBGene00008236", "Q21752", "WBGene00019900", "Q23536", "WBGene00002981" ] }, "reaction_10550411": { "compartment": "compartment_17906", "id": "reaction_10550411", "reactome": "R-CEL-5205672", "name": "Uncleaved Pink1 accumulates in damaged mitochondria", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10550393" ], "products": [ "species_10550389" ], "modifiers": [], "additional_components": [ "WBGene00017137", "WBGene00017137" ] }, "reaction_10550413": { "compartment": "compartment_70101", "id": "reaction_10550413", "reactome": "R-CEL-5205673", "name": "p62 binds ubiquitinated mitochondrial substrates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10550366", "species_10550360", "species_10550371", "species_10550354", "species_10550352" ], "products": [ "species_10550373" ], "modifiers": [], "additional_components": [ "WBGene00019900", "WBGene00008236", "WBGene00015552", "WBGene00001509", "WBGene00001509", "Q23424", "WBGene00001509", "Q17746", "WBGene00015552", "Q18746", "WBGene00008236", "Q21752", "WBGene00019900" ] }, "reaction_10568834": { "compartment": "compartment_17906", "id": "reaction_10568834", "reactome": "R-CEL-8948146", "name": "FUNDC1 is phosphorylated by ULK1 at Ser17", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10568806" ], "products": [ "species_10568831", "species_29370" ], "modifiers": [ [ "species_10568813", "catalyst" ] ], "additional_components": [ "WBGene00011528", "WBGene00011528", "WBGene00006786" ] }, "reaction_10570165": { "compartment": "compartment_70101", "id": "reaction_10570165", "reactome": "R-CEL-8959573", "name": "Phosphorylated FUNDC1 links damaged mitochondria to LC3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10568831", "species_10550378" ], "products": [ "species_10570159" ], "modifiers": [], "additional_components": [ "WBGene00011528", "WBGene00002981", "Q23536", "WBGene00002981", "Q22252", "WBGene00011528" ] }, "reaction_10568823": { "compartment": "compartment_70101", "id": "reaction_10568823", "reactome": "R-CEL-8948139", "name": "p-S13-FUNDC1 is dephosphorylated by PGAM5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10568809" ], "products": [ "species_10568806" ], "modifiers": [ [ "species_10568820", "catalyst" ] ], "additional_components": [ "WBGene00011528", "WBGene00011528", "WBGene00019941" ] }, "reaction_10568811": { "compartment": "compartment_70101", "id": "reaction_10568811", "reactome": "R-CEL-8948039", "name": "FUNDC1 is phosphorylated by CK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10568806" ], "products": [ "species_29370", "species_10568809" ], "modifiers": [ [ "species_10515097", "catalyst" ] ], "additional_components": [ "WBGene00011528", "WBGene00011528", "P18334", "WBGene00002191", "P28548", "WBGene00002196" ] }, "reaction_10568828": { "compartment": "compartment_70101", "id": "reaction_10568828", "reactome": "R-CEL-8948143", "name": "p-S13, FUNDC1 is phosphorylated by CK2 at Tyr18", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10568809" ], "products": [ "species_10568826", "species_29370" ], "modifiers": [ [ "species_10513079", "catalyst" ] ], "additional_components": [ "WBGene00011528", "WBGene00011528", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635" ] }, "reaction_10568815": { "compartment": "compartment_17906", "id": "reaction_10568815", "reactome": "R-CEL-8948136", "name": "ULK1 Translocates to the mitochondria", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10554651" ], "products": [ "species_10568813" ], "modifiers": [], "additional_components": [ "WBGene00006786", "WBGene00006786" ] }, "reaction_10527767": { "compartment": "compartment_984", "id": "reaction_10527767", "reactome": "R-CEL-629588", "name": "Binding of acetylcholine to highly sodium permeable postsynaptic acetylcholine receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10527685", "species_372533" ], "products": [ "species_10527687" ], "modifiers": [], "additional_components": [ "G5EDF1", "WBGene00000051", "Q93329", "WBGene00002975", "O17274", "WBGene00020836", "Q9N4M3", "WBGene00000045", "P48181", "WBGene00006765", "Q9N587", "WBGene00006797", "P48182", "WBGene00000042", "Q23022", "WBGene00006774", "Q23355", "WBGene00000047", "Q27218", "WBGene00002974", "Q93149", "WBGene00000043", "H2KZY7", "WBGene00022283", "species_372533", "G5EDF1", "WBGene00000051", "Q93329", "WBGene00002975", "O17274", "WBGene00020836", "Q9N4M3", "WBGene00000045", "P48181", "WBGene00006765", "Q9N587", "WBGene00006797", "P48182", "WBGene00000042", "Q23022", "WBGene00006774", "Q23355", "WBGene00000047", "Q27218", "WBGene00002974", "Q93149", "WBGene00000043", "H2KZY7", "WBGene00022283" ] }, "reaction_10527690": { "compartment": "compartment_876", "id": "reaction_10527690", "reactome": "R-CEL-622325", "name": "Activation of highly sodium permeable postsynaptic nicotinic acetylcholine receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74113" ], "products": [ "species_83910" ], "modifiers": [ [ "species_10527687", "catalyst" ] ], "additional_components": [ "species_372533", "G5EDF1", "WBGene00000051", "Q93329", "WBGene00002975", "O17274", "WBGene00020836", "Q9N4M3", "WBGene00000045", "P48181", "WBGene00006765", "Q9N587", "WBGene00006797", "P48182", "WBGene00000042", "Q23022", "WBGene00006774", "Q23355", "WBGene00000047", "Q27218", "WBGene00002974", "Q93149", "WBGene00000043", "H2KZY7", "WBGene00022283" ] }, "reaction_10564113": { "compartment": "compartment_7660", "id": "reaction_10564113", "reactome": "R-CEL-6811522", "name": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6810408", "species_29358" ], "products": [ "species_113582", "species_6810412" ], "modifiers": [ [ "species_10564110", "catalyst" ] ], "additional_components": [ "Q9BL73", "WBGene00004088" ] }, "reaction_10563787": { "compartment": "compartment_172574", "id": "reaction_10563787", "reactome": "R-CEL-6810392", "name": "TMEM55B translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10563783" ], "products": [ "species_10563785" ], "modifiers": [], "additional_components": [ "WBGene00022167", "WBGene00022167" ] }, "reaction_10563790": { "compartment": "compartment_7660", "id": "reaction_10563790", "reactome": "R-CEL-6810410", "name": "PI(4,5)P2 is dephosphorylated to PI5P by TMEM55B in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_6810412" ], "products": [ "species_6810408", "species_113550" ], "modifiers": [ [ "species_10563785", "catalyst" ] ], "additional_components": [ "WBGene00022167" ] }, "reaction_10511490": { "compartment": "compartment_876", "id": "reaction_10511490", "reactome": "R-CEL-170986", "name": "Ral-GDS binds to Ras-GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10511486", "species_10511481" ], "products": [ "species_10511488" ], "modifiers": [], "additional_components": [ "WBGene00017891", "species_29438", "P22981", "WBGene00002335", "species_29438", "P22981", "WBGene00002335", "Q19852", "WBGene00017891" ] }, "reaction_10512661": { "compartment": "compartment_70101", "id": "reaction_10512661", "reactome": "R-CEL-187688", "name": "p38 MAPK phosphorylates MAPKAPK2, MAPKAPK3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10512628" ], "products": [ "species_29370", "species_10512646" ], "modifiers": [ [ "species_10512658", "catalyst" ] ], "additional_components": [ "Q21360", "WBGene00010681", "Q965G5", "WBGene00007007", "Q21360", "WBGene00010681", "Q965G5", "WBGene00007007", "Q17446", "WBGene00004055", "Q8MXI4", "WBGene00004056", "species_114632" ] }, "reaction_10572080": { "compartment": "compartment_70101", "id": "reaction_10572080", "reactome": "R-CEL-9610166", "name": "p-T,Y MAPK dimers translocate to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10542082" ], "products": [ "species_10514067" ], "modifiers": [], "additional_components": [ "P39745", "WBGene00003401", "P39745", "WBGene00003401" ] }, "reaction_10572066": { "compartment": "compartment_74700", "id": "reaction_10572066", "reactome": "R-CEL-9610153", "name": "Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10572055" ], "products": [ "species_10572059", "species_29370" ], "modifiers": [ [ "species_10572055", "catalyst" ] ], "additional_components": [ "Q10664", "WBGene00003186", "Q18246", "WBGene00004307", "species_29438", "species_216785", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "Q07292", "WBGene00003030", "P39745", "WBGene00003401", "Q18246", "WBGene00004307", "species_29438", "species_216785", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "Q07292", "WBGene00003030", "Q10664", "WBGene00003186", "P39745", "WBGene00003401", "Q10664", "WBGene00003186", "Q18246", "WBGene00004307", "species_29438", "species_216785", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "Q07292", "WBGene00003030", "P39745", "WBGene00003401" ] }, "reaction_10572070": { "compartment": "compartment_70101", "id": "reaction_10572070", "reactome": "R-CEL-9610154", "name": "Dissociation of phosphorylated MAP2Ks and MAPKs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10572068" ], "products": [ "species_10555065", "species_10508583", "species_10572053" ], "modifiers": [], "additional_components": [ "Q18246", "WBGene00004307", "species_29438", "species_216785", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "Q07292", "WBGene00003030", "P39745", "WBGene00003401", "Q10664", "WBGene00003186", "Q10664", "WBGene00003186", "WBGene00003401", "Q18246", "WBGene00004307", "species_29438", "species_216785", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "Q07292", "WBGene00003030" ] }, "reaction_10572057": { "compartment": "compartment_74700", "id": "reaction_10572057", "reactome": "R-CEL-9610152", "name": "Activated BRAF recruits MAP2Ks and MAPKs to the endosome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508575", "species_10572053", "species_10555040" ], "products": [ "species_10572055" ], "modifiers": [], "additional_components": [ "WBGene00003401", "Q18246", "WBGene00004307", "species_29438", "species_216785", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "Q07292", "WBGene00003030", "Q10664", "WBGene00003186", "Q10664", "WBGene00003186", "Q18246", "WBGene00004307", "species_29438", "species_216785", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "Q07292", "WBGene00003030", "P39745", "WBGene00003401" ] }, "reaction_10572073": { "compartment": "compartment_70101", "id": "reaction_10572073", "reactome": "R-CEL-9610156", "name": "MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10572059", "species_113592" ], "products": [ "species_29370", "species_10572068" ], "modifiers": [ [ "species_10572059", "catalyst" ] ], "additional_components": [ "Q18246", "WBGene00004307", "species_29438", "species_216785", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "Q07292", "WBGene00003030", "Q10664", "WBGene00003186", "P39745", "WBGene00003401", "Q18246", "WBGene00004307", "species_29438", "species_216785", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "Q07292", "WBGene00003030", "P39745", "WBGene00003401", "Q10664", "WBGene00003186", "Q18246", "WBGene00004307", "species_29438", "species_216785", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "Q07292", "WBGene00003030", "Q10664", "WBGene00003186", "P39745", "WBGene00003401" ] }, "reaction_10555163": { "compartment": "compartment_70101", "id": "reaction_10555163", "reactome": "R-CEL-5674385", "name": "p-T,Y MAPKs dimerize", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508583" ], "products": [ "species_10542082" ], "modifiers": [], "additional_components": [ "WBGene00003401", "P39745", "WBGene00003401" ] }, "reaction_10572078": { "compartment": "compartment_74700", "id": "reaction_10572078", "reactome": "R-CEL-9610163", "name": "BRAF autophosphorylates downstream of RAP1 and NGF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10572075", "species_113592" ], "products": [ "species_29370", "species_10572053" ], "modifiers": [ [ "species_10572075", "catalyst" ] ], "additional_components": [ "Q18246", "WBGene00004307", "species_216785", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "Q07292", "WBGene00003030", "species_29438", "Q18246", "WBGene00004307", "species_29438", "species_216785", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "Q07292", "WBGene00003030", "Q18246", "WBGene00004307", "species_216785", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "Q07292", "WBGene00003030", "species_29438" ] }, "reaction_10572117": { "compartment": "compartment_7660", "id": "reaction_10572117", "reactome": "R-CEL-9612509", "name": "SGK phosphorylates SRF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10572112" ], "products": [ "species_113582", "species_10572115" ], "modifiers": [ [ "species_10572104", "catalyst" ] ], "additional_components": [ "WBGene00006844", "WBGene00006844", "WBGene00004789" ] }, "reaction_10572132": { "compartment": "compartment_7660", "id": "reaction_10572132", "reactome": "R-CEL-9613213", "name": "NAB2 and CHD4 bind and repress EGR-mediated RRAD gene expression", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10572122", "species_10547994", "species_10572128" ], "products": [ "species_10572130" ], "modifiers": [], "additional_components": [ "WBGene00003107", "G5EBZ4", "WBGene00002637", "Q22516", "WBGene00000482", "Q18250", "WBGene00007772", "G5EBZ4", "WBGene00002637", "Q22516", "WBGene00000482", "Q22002", "WBGene00003107", "Q18250", "WBGene00007772" ] }, "reaction_10572107": { "compartment": "compartment_7660", "id": "reaction_10572107", "reactome": "R-CEL-9612501", "name": "SGK phosphorylates CREB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10514243" ], "products": [ "species_113582", "species_10514246" ], "modifiers": [ [ "species_10572104", "catalyst" ] ], "additional_components": [ "WBGene00000793", "WBGene00000793", "WBGene00004789" ] }, "reaction_10514065": { "compartment": "compartment_7660", "id": "reaction_10514065", "reactome": "R-CEL-198746", "name": "ERK1/2/5 activate RSK1/2/3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10514008" ], "products": [ "species_113582", "species_10514054" ], "modifiers": [ [ "species_10514062", "catalyst" ] ], "additional_components": [ "Q19858", "WBGene00017898", "Q21734", "WBGene00011352", "Q21734", "WBGene00011352", "Q19858", "WBGene00017898", "P39745", "WBGene00003401", "H2KYF8", "WBGene00003402" ] }, "reaction_10514435": { "compartment": "compartment_7660", "id": "reaction_10514435", "reactome": "R-CEL-199959", "name": "ERKs are inactivated by protein phosphatase 2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10514062" ], "products": [ "species_113550", "species_10514418" ], "modifiers": [ [ "species_10514432", "catalyst" ] ], "additional_components": [ "P39745", "WBGene00003401", "H2KYF8", "WBGene00003402", "H2KYF8", "WBGene00003402", "P39745", "WBGene00003401", "A9UJN4", "WBGene00007554" ] }, "reaction_10514070": { "compartment": "compartment_7660", "id": "reaction_10514070", "reactome": "R-CEL-198756", "name": "ERK1/2 phosphorylates MSK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10513966" ], "products": [ "species_113582", "species_10513972" ], "modifiers": [ [ "species_10514067", "catalyst" ] ], "additional_components": [ "WBGene00008311", "WBGene00008311", "P39745", "WBGene00003401" ] }, "reaction_10513975": { "compartment": "compartment_7660", "id": "reaction_10513975", "reactome": "R-CEL-198669", "name": "p38MAPK phosphorylates MSK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10513966" ], "products": [ "species_113582", "species_10513972" ], "modifiers": [ [ "species_10510865", "catalyst" ] ], "additional_components": [ "WBGene00008311", "WBGene00008311", "Q17446", "WBGene00004055", "Q8MXI4", "WBGene00004056" ] }, "reaction_10515399": { "compartment": "compartment_7660", "id": "reaction_10515399", "reactome": "R-CEL-203797", "name": "ERKs are inactivated by dual-specific phosphatases (DUSPs)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10514062" ], "products": [ "species_113550", "species_10514418" ], "modifiers": [ [ "species_10515396", "catalyst" ] ], "additional_components": [ "P39745", "WBGene00003401", "H2KYF8", "WBGene00003402", "H2KYF8", "WBGene00003402", "P39745", "WBGene00003401", "Q9XUJ0", "WBGene00012372" ] }, "reaction_10514385": { "compartment": "compartment_7660", "id": "reaction_10514385", "reactome": "R-CEL-199895", "name": "RSK1/2/3 phosphorylates CREB at Serine 133", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10514243" ], "products": [ "species_113582", "species_10514246" ], "modifiers": [ [ "species_10514054", "catalyst" ] ], "additional_components": [ "WBGene00000793", "WBGene00000793", "Q21734", "WBGene00011352", "Q19858", "WBGene00017898" ] }, "reaction_10514402": { "compartment": "compartment_7660", "id": "reaction_10514402", "reactome": "R-CEL-199917", "name": "MAPKAPK2 phosphorylates CREB at Serine 133", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10514243" ], "products": [ "species_113582", "species_10514246" ], "modifiers": [ [ "species_10514399", "catalyst" ] ], "additional_components": [ "WBGene00000793", "WBGene00000793", "Q21360", "WBGene00010681", "Q965G5", "WBGene00007007" ] }, "reaction_10514404": { "compartment": "compartment_7660", "id": "reaction_10514404", "reactome": "R-CEL-199935", "name": "MSK1 activates CREB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10514243" ], "products": [ "species_113582", "species_10514246" ], "modifiers": [ [ "species_10513972", "catalyst" ] ], "additional_components": [ "WBGene00000793", "WBGene00000793", "WBGene00008311" ] }, "reaction_10514393": { "compartment": "compartment_7660", "id": "reaction_10514393", "reactome": "R-CEL-199910", "name": "MSK1 activates ATF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10514387" ], "products": [ "species_113582", "species_10514390" ], "modifiers": [ [ "species_10513972", "catalyst" ] ], "additional_components": [ "WBGene00000793", "WBGene00000793", "WBGene00008311" ] }, "reaction_10513986": { "compartment": "compartment_7660", "id": "reaction_10513986", "reactome": "R-CEL-198714", "name": "ERK5 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10513982" ], "products": [ "species_10513984" ], "modifiers": [], "additional_components": [ "WBGene00003402", "WBGene00003402" ] }, "reaction_10515269": { "compartment": "compartment_876", "id": "reaction_10515269", "reactome": "R-CEL-202692", "name": "PIP3 binds to RhoA and activates it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509484", "species_179838" ], "products": [ "species_10515267" ], "modifiers": [], "additional_components": [ "WBGene00004357", "Q22038", "WBGene00004357", "species_179838" ] }, "reaction_10545459": { "compartment": "compartment_876", "id": "reaction_10545459", "reactome": "R-CEL-2684507", "name": "Syndecans 1, 2, 4, (3) bind FGF2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10512869", "species_10541682" ], "products": [ "species_10545457" ], "modifiers": [], "additional_components": [ "WBGene00002881", "WBGene00004749", "P50605", "WBGene00004749", "Q11184", "WBGene00002881" ] }, "reaction_10545556": { "compartment": "compartment_876", "id": "reaction_10545556", "reactome": "R-CEL-2731074", "name": "Syndecan-1 binds Integrins alpha2beta1, (alpha6beta4)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10541682", "species_10545552" ], "products": [ "species_10545554" ], "modifiers": [], "additional_components": [ "WBGene00004749", "P34446", "WBGene00003929", "Q27874", "WBGene00003930", "P34446", "WBGene00003929", "Q27874", "WBGene00003930", "P50605", "WBGene00004749" ] }, "reaction_10545560": { "compartment": "compartment_876", "id": "reaction_10545560", "reactome": "R-CEL-2731078", "name": "Syndecans 2, (4) bind TGFB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10511429", "species_10541684" ], "products": [ "species_10545558" ], "modifiers": [], "additional_components": [ "G5EBY8", "WBGene00006852", "G5EEL5", "WBGene00000936", "WBGene00004749", "P50605", "WBGene00004749", "G5EBY8", "WBGene00006852", "G5EEL5", "WBGene00000936" ] }, "reaction_10545913": { "compartment": "compartment_876", "id": "reaction_10545913", "reactome": "R-CEL-2750187", "name": "Syndecan-4:PI(4,5)P2 binds PKC alpha:DAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10545909", "species_10521475" ], "products": [ "species_10545911" ], "modifiers": [], "additional_components": [ "species_179856", "P50605", "WBGene00004749", "P90980", "WBGene00004033", "species_114519", "P90980", "WBGene00004033", "species_114519", "species_179856", "P50605", "WBGene00004749" ] }, "reaction_10545564": { "compartment": "compartment_876", "id": "reaction_10545564", "reactome": "R-CEL-2731141", "name": "Syndecan-1 binds fibronectin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10541682", "species_10517394" ], "products": [ "species_10545562" ], "modifiers": [], "additional_components": [ "WBGene00004749", "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769", "P50605", "WBGene00004749" ] }, "reaction_10546406": { "compartment": "compartment_70101", "id": "reaction_10546406", "reactome": "R-CEL-3134954", "name": "DHX9 binds DNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_3134861", "species_10546400" ], "products": [ "species_10546402" ], "modifiers": [], "additional_components": [ "WBGene00004355", "Q22307", "WBGene00004355" ] }, "reaction_10546408": { "compartment": "compartment_70101", "id": "reaction_10546408", "reactome": "R-CEL-3134962", "name": "DHX36 binds DNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546396", "species_3134861" ], "products": [ "species_10546398" ], "modifiers": [], "additional_components": [ "WBGene00009922", "Q20644", "WBGene00009922" ] }, "reaction_10527102": { "compartment": "compartment_984", "id": "reaction_10527102", "reactome": "R-CEL-500708", "name": "GRIK3 homomer binds glutamate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_210382", "species_10526044" ], "products": [ "species_10527100" ], "modifiers": [], "additional_components": [ "A0A1T5HUM0", "WBGene00001618", "O01623", "WBGene00001616", "Q17697", "WBGene00001615", "species_2730999", "A0A1T5HUM0", "WBGene00001618", "O01623", "WBGene00001616", "Q17697", "WBGene00001615", "species_2730999", "species_113552" ] }, "reaction_10526120": { "compartment": "compartment_984", "id": "reaction_10526120", "reactome": "R-CEL-451309", "name": "Edited Kainate Receptor binds glutamate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_210382", "species_10526116" ], "products": [ "species_10526118" ], "modifiers": [], "additional_components": [ "A0A1T5HUM0", "WBGene00001618", "O01623", "WBGene00001616", "Q17697", "WBGene00001615", "species_2730999", "A0A1T5HUM0", "WBGene00001618", "O01623", "WBGene00001616", "Q17697", "WBGene00001615", "species_2730999", "species_113552" ] }, "reaction_10526123": { "compartment": "compartment_984", "id": "reaction_10526123", "reactome": "R-CEL-451310", "name": "Activation of Edited Kainate receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74113" ], "products": [ "species_83910" ], "modifiers": [ [ "species_10526118", "catalyst" ] ], "additional_components": [ "A0A1T5HUM0", "WBGene00001618", "O01623", "WBGene00001616", "Q17697", "WBGene00001615", "species_2730999", "species_113552" ] }, "reaction_10526080": { "compartment": "compartment_876", "id": "reaction_10526080", "reactome": "R-CEL-451283", "name": "kainate receptor binds glutamate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_210382", "species_10526076" ], "products": [ "species_10526078" ], "modifiers": [], "additional_components": [ "G5ECY0", "WBGene00001006", "Q22638", "WBGene00011890", "P36609", "WBGene00003564", "Q11083", "WBGene00020378", "P04630", "WBGene00000285", "G5EF37", "WBGene00003934", "A0A2C9C3L3", "WBGene00020378", "Q18136", "WBGene00006861", "Q09665", "WBGene00006583", "O02159", "WBGene00020378", "G5EDZ8", "WBGene00000288", "Q94288", "WBGene00000287", "Q09980", "WBGene00017394", "O16305", "WBGene00000552", "G5EEG0", "WBGene00000286", "O01623", "WBGene00001616", "Q17697", "WBGene00001615", "A0A1T5HUM0", "WBGene00001618", "species_2730999", "G5ECY0", "WBGene00001006", "Q22638", "WBGene00011890", "P36609", "WBGene00003564", "Q11083", "WBGene00020378", "P04630", "WBGene00000285", "G5EF37", "WBGene00003934", "A0A2C9C3L3", "WBGene00020378", "Q18136", "WBGene00006861", "Q09665", "WBGene00006583", "O02159", "WBGene00020378", "G5EDZ8", "WBGene00000288", "Q94288", "WBGene00000287", "Q09980", "WBGene00017394", "O16305", "WBGene00000552", "G5EEG0", "WBGene00000286", "O01623", "WBGene00001616", "Q17697", "WBGene00001615", "A0A1T5HUM0", "WBGene00001618", "species_2730999", "species_113552" ] }, "reaction_10526126": { "compartment": "compartment_70101", "id": "reaction_10526126", "reactome": "R-CEL-451311", "name": "Activation of Ca-permeable Kainate receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74112" ], "products": [ "species_74016" ], "modifiers": [ [ "species_10526078", "catalyst" ] ], "additional_components": [ "G5ECY0", "WBGene00001006", "Q22638", "WBGene00011890", "P36609", "WBGene00003564", "Q11083", "WBGene00020378", "P04630", "WBGene00000285", "G5EF37", "WBGene00003934", "A0A2C9C3L3", "WBGene00020378", "Q18136", "WBGene00006861", "Q09665", "WBGene00006583", "O02159", "WBGene00020378", "G5EDZ8", "WBGene00000288", "Q94288", "WBGene00000287", "Q09980", "WBGene00017394", "O16305", "WBGene00000552", "G5EEG0", "WBGene00000286", "O01623", "WBGene00001616", "Q17697", "WBGene00001615", "A0A1T5HUM0", "WBGene00001618", "species_2730999", "species_113552" ] }, "reaction_10526193": { "compartment": "compartment_5460", "id": "reaction_10526193", "reactome": "R-CEL-452036", "name": "arginine + H2O => ornithine + urea [ARG2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_374064", "species_113521" ], "products": [ "species_374061", "species_113585" ], "modifiers": [ [ "species_10526190", "catalyst" ] ], "additional_components": [ "species_266099", "A0A1X7RC97", "WBGene00020658" ] }, "reaction_10503273": { "compartment": "compartment_70101", "id": "reaction_10503273", "reactome": "R-CEL-70634", "name": "ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113567", "species_29498" ], "products": [ "species_113585", "species_29968" ], "modifiers": [ [ "species_10503270", "catalyst" ] ], "additional_components": [ "WBGene00020422" ] }, "reaction_10503167": { "compartment": "compartment_70101", "id": "reaction_10503167", "reactome": "R-CEL-70569", "name": "arginine + H2O => ornithine + urea [ARG1]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_29468" ], "products": [ "species_29514", "species_29498" ], "modifiers": [ [ "species_10503164", "catalyst" ] ], "additional_components": [ "A0A1X7RC97", "WBGene00020658", "species_266099" ] }, "reaction_10525558": { "compartment": "compartment_7660", "id": "reaction_10525558", "reactome": "R-CEL-450333", "name": "Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10525555" ], "products": [ "species_113582", "species_10525449" ], "modifiers": [ [ "species_10525533", "catalyst" ] ], "additional_components": [ "Q17446", "WBGene00004055", "Q8MXI4", "WBGene00004056", "Q965G5", "WBGene00007007", "Q21360", "WBGene00010681", "Q17446", "WBGene00004055", "Q8MXI4", "WBGene00004056", "Q965G5", "WBGene00007007", "Q21360", "WBGene00010681", "G5EDF7", "WBGene00004758", "Q58AU7", "WBGene00018034", "Q58AU8", "WBGene00018035" ] }, "reaction_10525464": { "compartment": "compartment_7660", "id": "reaction_10525464", "reactome": "R-CEL-450222", "name": "Active p38 MAPK phosphorylates MAPKAPK2 or 3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10525449" ], "products": [ "species_113582", "species_10525461" ], "modifiers": [ [ "species_10525449", "catalyst" ] ], "additional_components": [ "Q17446", "WBGene00004055", "Q8MXI4", "WBGene00004056", "Q965G5", "WBGene00007007", "Q21360", "WBGene00010681", "Q17446", "WBGene00004055", "Q8MXI4", "WBGene00004056", "Q965G5", "WBGene00007007", "Q21360", "WBGene00010681", "Q17446", "WBGene00004055", "Q8MXI4", "WBGene00004056", "Q965G5", "WBGene00007007", "Q21360", "WBGene00010681" ] }, "reaction_10525468": { "compartment": "compartment_70101", "id": "reaction_10525468", "reactome": "R-CEL-450257", "name": "Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10525461" ], "products": [ "species_10525466" ], "modifiers": [], "additional_components": [ "Q17446", "WBGene00004055", "Q8MXI4", "WBGene00004056", "Q965G5", "WBGene00007007", "Q21360", "WBGene00010681", "Q17446", "WBGene00004055", "Q8MXI4", "WBGene00004056", "Q21360", "WBGene00010681", "Q965G5", "WBGene00007007" ] }, "reaction_10525535": { "compartment": "compartment_70101", "id": "reaction_10525535", "reactome": "R-CEL-450296", "name": "Phosphorylated MKK3/MKK6 migrates to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10525521" ], "products": [ "species_10525533" ], "modifiers": [], "additional_components": [ "Q58AU7", "WBGene00018034", "Q58AU8", "WBGene00018035", "G5EDF7", "WBGene00004758", "G5EDF7", "WBGene00004758", "Q58AU7", "WBGene00018034", "Q58AU8", "WBGene00018035" ] }, "reaction_10525578": { "compartment": "compartment_70101", "id": "reaction_10525578", "reactome": "R-CEL-450348", "name": "Activated human JNKs migrate to nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10510969" ], "products": [ "species_10510908" ], "modifiers": [], "additional_components": [ "Q8WQG9", "WBGene00002178", "H2KZI0", "WBGene00002188", "O44408", "WBGene00002187", "Q8WQG9", "WBGene00002178", "H2KZI0", "WBGene00002188", "O44408", "WBGene00002187" ] }, "reaction_10510988": { "compartment": "compartment_70101", "id": "reaction_10510988", "reactome": "R-CEL-168162", "name": "Phosphorylation of human JNKs by activated MKK4/MKK7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10510949" ], "products": [ "species_29370", "species_10510969" ], "modifiers": [ [ "species_10510985", "catalyst" ] ], "additional_components": [ "Q8WQG9", "WBGene00002178", "H2KZI0", "WBGene00002188", "O44408", "WBGene00002187", "Q8WQG9", "WBGene00002178", "H2KZI0", "WBGene00002188", "O44408", "WBGene00002187", "Q21307", "WBGene00003185", "Q20347", "WBGene00003368" ] }, "reaction_10510992": { "compartment": "compartment_7660", "id": "reaction_10510992", "reactome": "R-CEL-168440", "name": "Formation of Activated Protein 1 (AP-1) complex. ATF2/c-JUN heterodimer. ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10510926", "species_10510845" ], "products": [ "species_10510990" ], "modifiers": [], "additional_components": [ "WBGene00012005", "WBGene00000223", "Q86MD3", "WBGene00000223", "G5ECU7", "WBGene00012005" ] }, "reaction_10510929": { "compartment": "compartment_7660", "id": "reaction_10510929", "reactome": "R-CEL-168136", "name": "Activated JNKs phosphorylate c-JUN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10510922" ], "products": [ "species_113582", "species_10510926" ], "modifiers": [ [ "species_10510908", "catalyst" ] ], "additional_components": [ "WBGene00012005", "WBGene00012005", "Q8WQG9", "WBGene00002178", "H2KZI0", "WBGene00002188", "O44408", "WBGene00002187" ] }, "reaction_10525492": { "compartment": "compartment_7660", "id": "reaction_10525492", "reactome": "R-CEL-450292", "name": "Formation of Activated Protein 1 (AP-1) complex. cFOS/c-JUN heterodimer. ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10510926", "species_10525488" ], "products": [ "species_10525490" ], "modifiers": [], "additional_components": [ "WBGene00012005", "G5ECG2", "WBGene00001345", "Q9N5A8", "WBGene00021082", "G5ECG2", "WBGene00001345", "Q9N5A8", "WBGene00021082", "G5ECU7", "WBGene00012005" ] }, "reaction_10510917": { "compartment": "compartment_7660", "id": "reaction_10510917", "reactome": "R-CEL-168053", "name": "Phosphorylated MAPKs phosphorylate ATF-2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10510841" ], "products": [ "species_113582", "species_10510845" ], "modifiers": [ [ "species_10510914", "catalyst" ] ], "additional_components": [ "WBGene00000223", "WBGene00000223", "Q17446", "WBGene00004055", "Q8MXI4", "WBGene00004056", "Q8WQG9", "WBGene00002178", "H2KZI0", "WBGene00002188", "O44408", "WBGene00002187" ] }, "reaction_10525543": { "compartment": "compartment_7660", "id": "reaction_10525543", "reactome": "R-CEL-450325", "name": "c-FOS activation by phospho ERK1/2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10525541" ], "products": [ "species_113582", "species_10525488" ], "modifiers": [ [ "species_10514067", "catalyst" ] ], "additional_components": [ "G5ECG2", "WBGene00001345", "Q9N5A8", "WBGene00021082", "G5ECG2", "WBGene00001345", "Q9N5A8", "WBGene00021082", "P39745", "WBGene00003401" ] }, "reaction_10528549": { "compartment": "compartment_13231", "id": "reaction_10528549", "reactome": "R-CEL-913529", "name": "Translocation of p-STAT1:p-STAT1 dimer to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10528455" ], "products": [ "species_10528543" ], "modifiers": [ [ "species_10528547", "catalyst" ] ], "additional_components": [ "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q22560", "WBGene00002072", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q9BIB8", "WBGene00002075" ] }, "reaction_10537425": { "compartment": "compartment_70101", "id": "reaction_10537425", "reactome": "R-CEL-1678843", "name": "ISGylation of protein translation regulator 4EHP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10537411", "species_10531955" ], "products": [ "species_10537413" ], "modifiers": [], "additional_components": [ "WBGene00002062", "Q9BL11", "WBGene00021685", "O01965", "WBGene00016158", "P91057", "WBGene00015842", "Q21633", "WBGene00006713", "Q22888", "WBGene00002062", "Q9BL11", "WBGene00021685", "O01965", "WBGene00016158", "P91057", "WBGene00015842", "Q21633", "WBGene00006713" ] }, "reaction_10531986": { "compartment": "compartment_70101", "id": "reaction_10531986", "reactome": "R-CEL-1169404", "name": "Transfer of ISG15 from E1 to E2 (UBCH8)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10529367", "species_10531957" ], "products": [ "species_10529372", "species_10531946" ], "modifiers": [ [ "species_10529367", "catalyst" ] ], "additional_components": [ "WBGene00006713", "P91057", "WBGene00015842", "Q27481", "WBGene00006699", "WBGene00006699", "P91057", "WBGene00015842", "Q21633", "WBGene00006713", "WBGene00006713" ] }, "reaction_10531971": { "compartment": "compartment_70101", "id": "reaction_10531971", "reactome": "R-CEL-1169398", "name": "ISGylation of host protein filamin B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10531966", "species_113592", "species_10531955" ], "products": [ "species_111294", "species_10529367", "species_10531953", "species_76577", "species_10531968" ], "modifiers": [ [ "species_10531955", "catalyst" ] ], "additional_components": [ "D0VWL6", "WBGene00016006", "U4PBJ9", "WBGene00022048", "Q9BL11", "WBGene00021685", "O01965", "WBGene00016158", "P91057", "WBGene00015842", "Q21633", "WBGene00006713", "WBGene00006713", "Q9BL11", "WBGene00021685", "O01965", "WBGene00016158", "P91057", "WBGene00015842", "D0VWL6", "WBGene00016006", "U4PBJ9", "WBGene00022048", "Q9BL11", "WBGene00021685", "O01965", "WBGene00016158", "P91057", "WBGene00015842", "Q21633", "WBGene00006713" ] }, "reaction_10531975": { "compartment": "compartment_70101", "id": "reaction_10531975", "reactome": "R-CEL-1169399", "name": "Interaction of ISG15 with NEDD4 and inhibition of Ebola virus budding", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10530876", "species_10529362" ], "products": [ "species_10531973" ], "modifiers": [], "additional_components": [ "WBGene00022358", "WBGene00015842", "P91057", "WBGene00015842", "A0A061ACQ8", "WBGene00022358" ] }, "reaction_10531960": { "compartment": "compartment_70101", "id": "reaction_10531960", "reactome": "R-CEL-1169397", "name": "Activation of ISG15 by UBA7 E1 ligase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10529372", "species_113592", "species_10529362" ], "products": [ "species_111294", "species_10531957", "species_76577" ], "modifiers": [ [ "species_10529372", "catalyst" ] ], "additional_components": [ "WBGene00006699", "WBGene00015842", "P91057", "WBGene00015842", "Q27481", "WBGene00006699", "WBGene00006699" ] }, "reaction_10531992": { "compartment": "compartment_70101", "id": "reaction_10531992", "reactome": "R-CEL-1169405", "name": "ISGylation of protein phosphatase 1 beta (PP2CB)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10531988", "species_10531955" ], "products": [ "species_111294", "species_10529367", "species_10531990", "species_10531953", "species_76577" ], "modifiers": [ [ "species_10531955", "catalyst" ] ], "additional_components": [ "WBGene00006460", "Q9BL11", "WBGene00021685", "O01965", "WBGene00016158", "P91057", "WBGene00015842", "Q21633", "WBGene00006713", "WBGene00006713", "P91057", "WBGene00015842", "Q19775", "WBGene00006460", "Q9BL11", "WBGene00021685", "O01965", "WBGene00016158", "Q9BL11", "WBGene00021685", "O01965", "WBGene00016158", "P91057", "WBGene00015842", "Q21633", "WBGene00006713" ] }, "reaction_10532011": { "compartment": "compartment_70101", "id": "reaction_10532011", "reactome": "R-CEL-1169406", "name": "ISGylation of host proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10532007", "species_10531955" ], "products": [ "species_111294", "species_10532009", "species_10529367", "species_10531953", "species_76577" ], "modifiers": [ [ "species_10531955", "catalyst" ] ], "additional_components": [ "P39745", "WBGene00003401", "H8W3X5", "WBGene00219376", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q22070", "WBGene00004038", "Q9BL11", "WBGene00021685", "O01965", "WBGene00016158", "P91057", "WBGene00015842", "Q21633", "WBGene00006713", "P91057", "WBGene00015842", "P39745", "WBGene00003401", "H8W3X5", "WBGene00219376", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q22070", "WBGene00004038", "WBGene00006713", "Q9BL11", "WBGene00021685", "O01965", "WBGene00016158", "Q9BL11", "WBGene00021685", "O01965", "WBGene00016158", "P91057", "WBGene00015842", "Q21633", "WBGene00006713" ] }, "reaction_10531981": { "compartment": "compartment_70101", "id": "reaction_10531981", "reactome": "R-CEL-1169402", "name": "ISGylation of E2 conjugating enzymes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10531977", "species_10531955" ], "products": [ "species_111294", "species_10531979", "species_10529367", "species_10531953", "species_76577" ], "modifiers": [ [ "species_10531955", "catalyst" ] ], "additional_components": [ "Q95XX0", "WBGene00006708", "H8W3X5", "WBGene00219376", "Q9BL11", "WBGene00021685", "O01965", "WBGene00016158", "P91057", "WBGene00015842", "Q21633", "WBGene00006713", "P91057", "WBGene00015842", "Q95XX0", "WBGene00006708", "H8W3X5", "WBGene00219376", "WBGene00006713", "Q9BL11", "WBGene00021685", "O01965", "WBGene00016158", "Q9BL11", "WBGene00021685", "O01965", "WBGene00016158", "P91057", "WBGene00015842", "Q21633", "WBGene00006713" ] }, "reaction_10537406": { "compartment": "compartment_70101", "id": "reaction_10537406", "reactome": "R-CEL-1678841", "name": "Regulation of protein ISGylation by ISG15 deconjugating enzyme USP18", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10532009" ], "products": [ "species_10532007", "species_141681" ], "modifiers": [ [ "species_10537403", "catalyst" ] ], "additional_components": [ "P91057", "WBGene00015842", "P39745", "WBGene00003401", "H8W3X5", "WBGene00219376", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q22070", "WBGene00004038", "P39745", "WBGene00003401", "H8W3X5", "WBGene00219376", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q22070", "WBGene00004038", "H2L010", "WBGene00020695" ] }, "reaction_10531983": { "compartment": "compartment_70101", "id": "reaction_10531983", "reactome": "R-CEL-1169403", "name": "Interaction of E3 ligase with ISG15:E2 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10531946", "species_10531953" ], "products": [ "species_10531955" ], "modifiers": [], "additional_components": [ "P91057", "WBGene00015842", "Q21633", "WBGene00006713", "Q9BL11", "WBGene00021685", "O01965", "WBGene00016158", "Q9BL11", "WBGene00021685", "O01965", "WBGene00016158", "P91057", "WBGene00015842", "Q21633", "WBGene00006713" ] }, "reaction_10537423": { "compartment": "compartment_70101", "id": "reaction_10537423", "reactome": "R-CEL-1678842", "name": "Competitive inhibition of translation initiation by ISGylated 4EHP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10537419", "species_10537413" ], "products": [ "species_10537421", "species_10537417" ], "modifiers": [], "additional_components": [ "Q20935", "WBGene00018997", "P27639", "WBGene00002083", "Q9BL61", "WBGene00022029", "A0A486WX07", "WBGene00002066", "O61955", "WBGene00002061", "Q22888", "WBGene00002062", "Q9BL11", "WBGene00021685", "O01965", "WBGene00016158", "P91057", "WBGene00015842", "Q21633", "WBGene00006713", "Q22888", "WBGene00002062", "Q9BL11", "WBGene00021685", "O01965", "WBGene00016158", "P91057", "WBGene00015842", "Q21633", "WBGene00006713", "Q20935", "WBGene00018997", "P27639", "WBGene00002083", "Q9BL61", "WBGene00022029", "A0A486WX07", "WBGene00002066", "O61955", "WBGene00002061" ] }, "reaction_10570813": { "compartment": "compartment_70101", "id": "reaction_10570813", "reactome": "R-CEL-9009950", "name": "PDE12 cleaves 2'-5' oligoadenylates ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_8983696" ], "products": [ "species_70106", "species_113592", "species_76577" ], "modifiers": [ [ "species_10570810", "catalyst" ] ], "additional_components": [ "species_29358", "WBGene00011268" ] }, "reaction_10528100": { "compartment": "compartment_7660", "id": "reaction_10528100", "reactome": "R-CEL-877281", "name": "PIAS1 binds p-STAT1 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10528077", "species_10528091", "species_10528096" ], "products": [ "species_10528098" ], "modifiers": [], "additional_components": [ "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q21970", "WBGene00011259", "Q94361", "WBGene00001574", "WBGene00004888", "P55853", "WBGene00004888", "Q21970", "WBGene00011259", "Q94361", "WBGene00001574", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111" ] }, "reaction_10528079": { "compartment": "compartment_13231", "id": "reaction_10528079", "reactome": "R-CEL-873917", "name": "Translocation of STAT1 dimer to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10528069" ], "products": [ "species_10528077" ], "modifiers": [], "additional_components": [ "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111" ] }, "reaction_10554345": { "compartment": "compartment_876", "id": "reaction_10554345", "reactome": "R-CEL-5654511", "name": "FGFRL1 dimer binds FGFs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10554341", "species_10554339", "species_190915" ], "products": [ "species_10554343" ], "modifiers": [], "additional_components": [ "G5EEF1", "WBGene00001185", "Q95XJ7", "WBGene00022418", "species_190915", "Q95XJ7", "WBGene00022418", "G5EEF1", "WBGene00001185" ] }, "reaction_10554354": { "compartment": "compartment_984", "id": "reaction_10554354", "reactome": "R-CEL-5654515", "name": "KAL1 binds HS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10554350", "species_190915" ], "products": [ "species_10554352" ], "modifiers": [], "additional_components": [ "WBGene00002181", "species_190915", "G5EDX1", "WBGene00002181" ] }, "reaction_10554370": { "compartment": "compartment_70101", "id": "reaction_10554370", "reactome": "R-CEL-5654690", "name": "FGFR1-associated PI3K phosphorylates PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10543825", "catalyst" ] ], "additional_components": [ "Q94125", "WBGene00000090", "G5EDP9", "WBGene00000001", "P29355", "WBGene00004774", "G5EDJ4", "WBGene00004928", "E6N0V1", "WBGene00018819" ] }, "reaction_10512173": { "compartment": "compartment_70101", "id": "reaction_10512173", "reactome": "R-CEL-177931", "name": "Binding of PIK3 regulatory alpha subunit to GRB2:GAB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10512121", "species_10506883" ], "products": [ "species_10512171" ], "modifiers": [], "additional_components": [ "P29355", "WBGene00004774", "G5EDJ4", "WBGene00004928", "WBGene00000001", "G5EDP9", "WBGene00000001", "P29355", "WBGene00004774", "G5EDJ4", "WBGene00004928" ] }, "reaction_10554373": { "compartment": "compartment_70101", "id": "reaction_10554373", "reactome": "R-CEL-5654697", "name": "FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10543855", "catalyst" ] ], "additional_components": [ "Q94125", "WBGene00000090", "G5EDP9", "WBGene00000001", "P29355", "WBGene00004774", "G5EDJ4", "WBGene00004928", "E6N0V1", "WBGene00018819" ] }, "reaction_10554358": { "compartment": "compartment_70101", "id": "reaction_10554358", "reactome": "R-CEL-5654614", "name": "Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10506890", "species_10543831" ], "products": [ "species_10543833" ], "modifiers": [], "additional_components": [ "WBGene00000090", "E6N0V1", "WBGene00018819", "G5EDP9", "WBGene00000001", "P29355", "WBGene00004774", "G5EDJ4", "WBGene00004928", "E6N0V1", "WBGene00018819", "G5EDP9", "WBGene00000001", "P29355", "WBGene00004774", "G5EDJ4", "WBGene00004928", "Q94125", "WBGene00000090" ] }, "reaction_10554376": { "compartment": "compartment_70101", "id": "reaction_10554376", "reactome": "R-CEL-5654701", "name": "FGFR2-associated PI3K phosphorylates PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10543833", "catalyst" ] ], "additional_components": [ "E6N0V1", "WBGene00018819", "G5EDP9", "WBGene00000001", "P29355", "WBGene00004774", "G5EDJ4", "WBGene00004928", "Q94125", "WBGene00000090" ] }, "reaction_10554365": { "compartment": "compartment_70101", "id": "reaction_10554365", "reactome": "R-CEL-5654618", "name": "Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10512175", "species_29438" ], "products": [ "species_29420", "species_10511481" ], "modifiers": [ [ "species_10554362", "catalyst" ] ], "additional_components": [ "species_29420", "P22981", "WBGene00002335", "species_29438", "P22981", "WBGene00002335", "P29355", "WBGene00004774", "Q9N5D3", "WBGene00004947" ] }, "reaction_10562965": { "compartment": "compartment_7660", "id": "reaction_10562965", "reactome": "R-CEL-6803523", "name": "PTB and hnRNPA1 bind FGFR2 pre-mRNA to repress IIIb splicing and promote formation of FGFR2c mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10504458", "species_10504465", "species_10562961" ], "products": [ "species_10562963" ], "modifiers": [], "additional_components": [ "WBGene00004207", "WBGene00019881", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "P34541", "WBGene00019881", "Q18999", "WBGene00004207" ] }, "reaction_10554385": { "compartment": "compartment_70101", "id": "reaction_10554385", "reactome": "R-CEL-5654717", "name": "FGFR4-associated PI3K phosphorylates PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10543849", "catalyst" ] ], "additional_components": [ "E6N0V1", "WBGene00018819", "G5EDP9", "WBGene00000001", "P29355", "WBGene00004774", "G5EDJ4", "WBGene00004928", "Q94125", "WBGene00000090" ] }, "reaction_10554332": { "compartment": "compartment_70101", "id": "reaction_10554332", "reactome": "R-CEL-5654413", "name": "Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10512175", "species_29438" ], "products": [ "species_29420", "species_10511481" ], "modifiers": [ [ "species_10554329", "catalyst" ] ], "additional_components": [ "species_29420", "P22981", "WBGene00002335", "species_29438", "P22981", "WBGene00002335", "P29355", "WBGene00004774", "Q9N5D3", "WBGene00004947" ] }, "reaction_10554379": { "compartment": "compartment_70101", "id": "reaction_10554379", "reactome": "R-CEL-5654705", "name": "FGFR3-associated PI3K phosphorylates PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10543841", "catalyst" ] ], "additional_components": [ "Q94125", "WBGene00000090", "G5EDP9", "WBGene00000001", "P29355", "WBGene00004774", "G5EDJ4", "WBGene00004928", "E6N0V1", "WBGene00018819" ] }, "reaction_10554367": { "compartment": "compartment_70101", "id": "reaction_10554367", "reactome": "R-CEL-5654640", "name": "Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10543839", "species_10506890" ], "products": [ "species_10543841" ], "modifiers": [], "additional_components": [ "G5EDP9", "WBGene00000001", "P29355", "WBGene00004774", "G5EDJ4", "WBGene00004928", "E6N0V1", "WBGene00018819", "WBGene00000090", "Q94125", "WBGene00000090", "G5EDP9", "WBGene00000001", "P29355", "WBGene00004774", "G5EDJ4", "WBGene00004928", "E6N0V1", "WBGene00018819" ] }, "reaction_10554382": { "compartment": "compartment_70101", "id": "reaction_10554382", "reactome": "R-CEL-5654709", "name": "FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10543861", "catalyst" ] ], "additional_components": [ "E6N0V1", "WBGene00018819", "G5EDP9", "WBGene00000001", "P29355", "WBGene00004774", "G5EDJ4", "WBGene00004928", "Q94125", "WBGene00000090" ] }, "reaction_10546375": { "compartment": "compartment_70101", "id": "reaction_10546375", "reactome": "R-CEL-3134914", "name": "Beta-catenin migrates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546373" ], "products": [ "species_10546371" ], "modifiers": [], "additional_components": [ "WBGene00001979", "WBGene00001979" ] }, "reaction_10536514": { "compartment": "compartment_70101", "id": "reaction_10536514", "reactome": "R-CEL-1614567", "name": "Excess homocysteine yields homolanthionine and H2S", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_174369" ], "products": [ "species_1614532", "species_1614594" ], "modifiers": [ [ "species_10536511", "catalyst" ], [ "species_174369", "catalyst" ] ], "additional_components": [ "P55216", "WBGene00022856" ] }, "reaction_10571811": { "compartment": "compartment_5460", "id": "reaction_10571811", "reactome": "R-CEL-9034756", "name": "MPST transfers sulfur atom from 3MPYR to form CysS248-MPST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9012592", "species_10570931" ], "products": [ "species_113557", "species_10571809" ], "modifiers": [ [ "species_10570931", "catalyst" ] ], "additional_components": [ "WBGene00022006", "WBGene00022006", "WBGene00022006" ] }, "reaction_10571815": { "compartment": "compartment_5460", "id": "reaction_10571815", "reactome": "R-CEL-9035227", "name": "TXN2 binds CysS248-MPST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10547396", "species_10571809" ], "products": [ "species_10571813" ], "modifiers": [], "additional_components": [ "WBGene00007099", "WBGene00022006", "G5ECA0", "WBGene00022006", "Q17424", "WBGene00007099" ] }, "reaction_10536520": { "compartment": "compartment_70101", "id": "reaction_10536520", "reactome": "R-CEL-1614591", "name": "Excess cysteine yields lanthionine and H2S", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111707" ], "products": [ "species_1614582", "species_1614532" ], "modifiers": [ [ "species_10536511", "catalyst" ], [ "species_111707", "catalyst" ] ], "additional_components": [ "P55216", "WBGene00022856" ] }, "reaction_10571817": { "compartment": "compartment_5460", "id": "reaction_10571817", "reactome": "R-CEL-9035484", "name": "CysS248-MPST:TXN2 dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10571813" ], "products": [ "species_10547399", "species_10570931", "species_1655881" ], "modifiers": [], "additional_components": [ "G5ECA0", "WBGene00022006", "Q17424", "WBGene00007099", "WBGene00007099", "WBGene00022006" ] }, "reaction_10536553": { "compartment": "compartment_70101", "id": "reaction_10536553", "reactome": "R-CEL-1614645", "name": "CDO1:Fe2+ oxidises L-Cys to 3-Sulfinoalanine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111707", "species_29368" ], "products": [ "species_1614519" ], "modifiers": [ [ "species_10536550", "catalyst" ] ], "additional_components": [ "Q20893", "WBGene00018986", "species_113531" ] }, "reaction_10536501": { "compartment": "compartment_5460", "id": "reaction_10536501", "reactome": "R-CEL-1614544", "name": "Sulfite is oxidized to sulfate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113533", "species_1614538", "species_113521" ], "products": [ "species_1614617", "species_1614584" ], "modifiers": [ [ "species_10536498", "catalyst" ] ], "additional_components": [ "Q9XTQ8", "WBGene00010397", "species_947539" ] }, "reaction_10536503": { "compartment": "compartment_70616", "id": "reaction_10536503", "reactome": "R-CEL-1614546", "name": "Sulfate is exported to the cytosol in exchange for dicarboxylate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_198498", "species_1614584" ], "products": [ "species_113544", "species_174375" ], "modifiers": [ [ "species_10518419", "catalyst" ] ], "additional_components": [ "WBGene00019656" ] }, "reaction_10536538": { "compartment": "compartment_70616", "id": "reaction_10536538", "reactome": "R-CEL-1614605", "name": "Persulfide sulfur is dioxygenated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10536526", "species_113533", "species_113521" ], "products": [ "species_113529", "species_1614538", "species_10536528" ], "modifiers": [ [ "species_10536535", "catalyst" ] ], "additional_components": [ "WBGene00008538", "WBGene00008538", "O17636", "WBGene00007886", "species_216785" ] }, "reaction_10571219": { "compartment": "compartment_5460", "id": "reaction_10571219", "reactome": "R-CEL-9013471", "name": "MPST transfers sulfur from 3MPYR to HCN to form HSCN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9012592", "species_9013199" ], "products": [ "species_9013191", "species_113557" ], "modifiers": [ [ "species_10570931", "catalyst" ] ], "additional_components": [ "WBGene00022006" ] }, "reaction_10571186": { "compartment": "compartment_5460", "id": "reaction_10571186", "reactome": "R-CEL-9013198", "name": "TST transfers sulfur from S2O3(2-) to HCN to form HSCN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1614595", "species_9013199" ], "products": [ "species_9013207", "species_9013191" ], "modifiers": [ [ "species_10571183", "catalyst" ] ], "additional_components": [ "G5ECA0", "WBGene00022006", "O17730", "WBGene00008409", "G5EEV0", "WBGene00011307", "P91247", "WBGene00017387", "Q9XTX2", "WBGene00010380", "H9G340", "WBGene00010383" ] }, "reaction_10571221": { "compartment": "compartment_5460", "id": "reaction_10571221", "reactome": "R-CEL-9013533", "name": "MPST transfers sulfur from sulfanegen to HCN to form HSCN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9013543", "species_9013199" ], "products": [ "species_9013191", "species_113557" ], "modifiers": [ [ "species_10570931", "catalyst" ] ], "additional_components": [ "WBGene00022006" ] }, "reaction_10564244": { "compartment": "compartment_70101", "id": "reaction_10564244", "reactome": "R-CEL-6814153", "name": "ADO oxidises 2AET to HTAU", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_6814151" ], "products": [ "species_1655445", "species_70106" ], "modifiers": [ [ "species_10564241", "catalyst" ] ], "additional_components": [ "species_113531", "Q8IAA1", "WBGene00021750" ] }, "reaction_10570934": { "compartment": "compartment_5460", "id": "reaction_10570934", "reactome": "R-CEL-9012721", "name": "MPST transfers sulfur atom from 3MPYR to HSO3- to form S2O3(2-) and PYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9012724", "species_9012592" ], "products": [ "species_1614595", "species_113557" ], "modifiers": [ [ "species_10570931", "catalyst" ] ], "additional_components": [ "WBGene00022006" ] }, "reaction_10536540": { "compartment": "compartment_70101", "id": "reaction_10536540", "reactome": "R-CEL-1614614", "name": "Cysteine is degraded to serine and H2S", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_111707" ], "products": [ "species_1614532", "species_200736" ], "modifiers": [ [ "species_10536511", "catalyst" ] ], "additional_components": [ "P55216", "WBGene00022856" ] }, "reaction_10536543": { "compartment": "compartment_70101", "id": "reaction_10536543", "reactome": "R-CEL-1614631", "name": "Homocysteine is degraded to oxobutanoate and H2S", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_174369" ], "products": [ "species_1614532", "species_29382", "species_936714" ], "modifiers": [ [ "species_10536511", "catalyst" ] ], "additional_components": [ "P55216", "WBGene00022856" ] }, "reaction_10507392": { "compartment": "compartment_70101", "id": "reaction_10507392", "reactome": "R-CEL-75849", "name": "Transport of Citrate from Mitochondrial Matrix to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29654", "species_198498" ], "products": [ "species_76190", "species_113544" ], "modifiers": [ [ "species_10507389", "catalyst" ] ], "additional_components": [ "WBGene00010780" ] }, "reaction_10556609": { "compartment": "compartment_161320", "id": "reaction_10556609", "reactome": "R-CEL-5690517", "name": "PPT1 hydrolyses palmitoylated proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_5690533" ], "products": [ "species_6785219", "species_5690516" ], "modifiers": [ [ "species_10556606", "catalyst" ] ], "additional_components": [ "species_390435", "species_6785219", "WBGene00004092" ] }, "reaction_10527328": { "compartment": "compartment_70101", "id": "reaction_10527328", "reactome": "R-CEL-548843", "name": "ACSL3,4 ligate CoA to AA to form AA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_29768", "species_76194" ], "products": [ "species_111294", "species_29356", "species_548819", "species_76577" ], "modifiers": [ [ "species_10527325", "catalyst" ] ], "additional_components": [ "A0A4V0ING4", "WBGene00016716" ] }, "reaction_10527264": { "compartment": "compartment_70101", "id": "reaction_10527264", "reactome": "R-CEL-548800", "name": "ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_548819", "species_29508" ], "products": [ "species_113528", "species_548816", "species_76194" ], "modifiers": [ [ "species_10527261", "catalyst" ] ], "additional_components": [ "WBGene00001241" ] }, "reaction_10555303": { "compartment": "compartment_12045", "id": "reaction_10555303", "reactome": "R-CEL-5676637", "name": "PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5676631" ], "products": [ "species_29356", "species_5676634" ], "modifiers": [ [ "species_10555300", "catalyst" ] ], "additional_components": [ "O17040", "WBGene00020517" ] }, "reaction_10527321": { "compartment": "compartment_70101", "id": "reaction_10527321", "reactome": "R-CEL-548831", "name": "TECR,TECRL dehydrogenate TOD-CoA to ST-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_548809" ], "products": [ "species_428139", "species_29366" ], "modifiers": [ [ "species_10527316", "catalyst" ] ], "additional_components": [ "WBGene00000198" ] }, "reaction_10527308": { "compartment": "compartment_70101", "id": "reaction_10527308", "reactome": "R-CEL-548814", "name": "ELOVL3,6,7 elongate PALM-CoA and Mal-CoA to 3OOD-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29508", "species_200993" ], "products": [ "species_113528", "species_548812", "species_76194" ], "modifiers": [ [ "species_10527305", "catalyst" ] ], "additional_components": [ "Q9NAC6", "WBGene00001247", "Q20300", "WBGene00001243", "G5EEE5", "WBGene00001239", "Q9XVQ9", "WBGene00001240", "Q20303", "WBGene00001244", "P49191", "WBGene00001241", "Q20904", "WBGene00001245", "Q03574", "WBGene00001242" ] }, "reaction_10514751": { "compartment": "compartment_70101", "id": "reaction_10514751", "reactome": "R-CEL-201035", "name": "ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_3632881", "species_76194" ], "products": [ "species_111294", "species_29356", "species_200993", "species_76577" ], "modifiers": [ [ "species_10514748", "catalyst" ] ], "additional_components": [ "Q9XWD1", "WBGene00013575", "O16775", "WBGene00019920", "V6CLI5", "WBGene00022037", "O44560", "WBGene00020343", "Q21872", "WBGene00011173", "A0A4V0ING4", "WBGene00016716", "Q20121", "WBGene00018152" ] }, "reaction_10527311": { "compartment": "compartment_70101", "id": "reaction_10527311", "reactome": "R-CEL-548818", "name": "HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_548812" ], "products": [ "species_548836", "species_29366" ], "modifiers": [ [ "species_10513362", "catalyst" ] ], "additional_components": [ "WBGene00000969" ] }, "reaction_10507383": { "compartment": "compartment_70101", "id": "reaction_10507383", "reactome": "R-CEL-75848", "name": "ACLY tetramer transforms CIT to Ac-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76190", "species_113592", "species_76194" ], "products": [ "species_29372", "species_29370", "species_76183", "species_76213" ], "modifiers": [ [ "species_10507375", "catalyst" ], [ "species_10507381", "catalyst" ] ], "additional_components": [ "P53585", "WBGene00016995", "WBGene00022531" ] }, "reaction_10514618": { "compartment": "compartment_70101", "id": "reaction_10514618", "reactome": "R-CEL-200555", "name": "acetyl-CoA + bicarbonate + ATP => malonyl-CoA + H2O + ADP + orthophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111627", "species_113592", "species_76183" ], "products": [ "species_29372", "species_29370", "species_29508" ], "modifiers": [ [ "species_10507411", "catalyst" ], [ "species_76190", "catalyst" ] ], "additional_components": [ "Q9XUC3", "WBGene00012131", "H2L0M0", "WBGene00004076" ] }, "reaction_10556619": { "compartment": "compartment_12045", "id": "reaction_10556619", "reactome": "R-CEL-5690565", "name": "SCD desaturates ST-CoA to OLE-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428139", "species_70106", "species_4085415", "species_29368" ], "products": [ "species_4085425", "species_29356", "species_5690558" ], "modifiers": [ [ "species_10556616", "catalyst" ] ], "additional_components": [ "G5EGN2", "WBGene00001398" ] }, "reaction_10510254": { "compartment": "compartment_70101", "id": "reaction_10510254", "reactome": "R-CEL-163756", "name": "Formation of fatty acid synthase (FAS) dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10507450" ], "products": [ "species_10507452" ], "modifiers": [], "additional_components": [ "WBGene00009342", "P91871", "WBGene00009342" ] }, "reaction_10507455": { "compartment": "compartment_70101", "id": "reaction_10507455", "reactome": "R-CEL-75872", "name": "acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_76183", "species_29364", "species_29508" ], "products": [ "species_29356", "species_113528", "species_29366", "species_3632881", "species_76194" ], "modifiers": [ [ "species_10507452", "catalyst" ] ], "additional_components": [ "P91871", "WBGene00009342" ] }, "reaction_10564542": { "compartment": "compartment_12045", "id": "reaction_10564542", "reactome": "R-CEL-8847579", "name": "SCD5 desaturates ST-CoA to OLE-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428139", "species_70106", "species_4085415", "species_29368" ], "products": [ "species_4085425", "species_29356", "species_5690558" ], "modifiers": [ [ "species_10564539", "catalyst" ] ], "additional_components": [ "G5ED44", "WBGene00001397", "G5EGH6", "WBGene00001399", "G5EGN2", "WBGene00001398" ] }, "reaction_10571480": { "compartment": "compartment_70101", "id": "reaction_10571480", "reactome": "R-CEL-9018877", "name": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(R)-HEPE to 18(R)-RvE1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_9023708" ], "products": [ "species_9023712" ], "modifiers": [ [ "species_10517863", "catalyst" ] ], "additional_components": [ "species_216785", "G5EFT4", "WBGene00016589" ] }, "reaction_10571482": { "compartment": "compartment_70101", "id": "reaction_10571482", "reactome": "R-CEL-9018895", "name": "GPX4-2 reduces 18(R)-HpEPE to 18(R)-HEPE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9023653", "species_29450" ], "products": [ "species_29356", "species_9023651", "species_111745" ], "modifiers": [ [ "species_10571475", "catalyst" ] ], "additional_components": [ "WBGene00019846" ] }, "reaction_10569921": { "compartment": "compartment_17947", "id": "reaction_10569921", "reactome": "R-CEL-8953946", "name": "PEX2:PEX10:PEX12 monoubiquitinates PEX5S,L at cysteine-11", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10569909" ], "products": [ "species_10569918", "species_10532186" ], "modifiers": [ [ "species_10569909", "catalyst" ] ], "additional_components": [ "P35129", "WBGene00002344", "P91853", "WBGene00006732", "Q17720", "WBGene00006717", "Q20617", "WBGene00006719", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "Q19951", "WBGene00004198", "Q93930", "WBGene00004199", "Q18355", "WBGene00016318", "Q19189", "WBGene00004197", "Q18426", "WBGene00004194", "Q19951", "WBGene00004198", "Q93930", "WBGene00004199", "Q18355", "WBGene00016318", "Q19189", "WBGene00004197", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "Q18426", "WBGene00004194", "P35129", "WBGene00002344", "P91853", "WBGene00006732", "Q17720", "WBGene00006717", "Q20617", "WBGene00006719", "P35129", "WBGene00002344", "P91853", "WBGene00006732", "Q17720", "WBGene00006717", "Q20617", "WBGene00006719", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "Q19951", "WBGene00004198", "Q93930", "WBGene00004199", "Q18355", "WBGene00016318", "Q19189", "WBGene00004197", "Q18426", "WBGene00004194" ] }, "reaction_10569911": { "compartment": "compartment_17947", "id": "reaction_10569911", "reactome": "R-CEL-8953917", "name": "PEX2:PEX10:PEX12 binds PEX5S,L (in PEX5S:PEX13:PEX14) and Ub:UBE2D1,2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10569900", "species_10569907" ], "products": [ "species_10569909" ], "modifiers": [], "additional_components": [ "Q19951", "WBGene00004198", "Q93930", "WBGene00004199", "Q18355", "WBGene00016318", "Q19189", "WBGene00004197", "Q18426", "WBGene00004194", "P35129", "WBGene00002344", "P91853", "WBGene00006732", "Q17720", "WBGene00006717", "Q20617", "WBGene00006719", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "P35129", "WBGene00002344", "P91853", "WBGene00006732", "Q17720", "WBGene00006717", "Q20617", "WBGene00006719", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "Q19951", "WBGene00004198", "Q93930", "WBGene00004199", "Q18355", "WBGene00016318", "Q19189", "WBGene00004197", "Q18426", "WBGene00004194" ] }, "reaction_10568412": { "compartment": "compartment_70101", "id": "reaction_10568412", "reactome": "R-CEL-8938815", "name": "RNF152 polyubiquitinates RRAGA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10568399", "species_10568401" ], "products": [ "species_10568392", "species_10568409", "species_10515250" ], "modifiers": [ [ "species_10568401", "catalyst" ] ], "additional_components": [ "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "Q95XX0", "WBGene00006708", "Q19214", "WBGene00008588", "species_29420", "Q22743", "WBGene00006414", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "Q95XX0", "WBGene00006708", "WBGene00008588", "Q22743", "WBGene00006414", "species_29420", "WBGene00006708", "Q19214", "WBGene00008588", "species_29420", "Q22743", "WBGene00006414", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "Q95XX0", "WBGene00006708" ] }, "reaction_10568414": { "compartment": "compartment_70101", "id": "reaction_10568414", "reactome": "R-CEL-8938829", "name": "RNF152 binds RRAGA:GDP and Ubiquitin:UBE2D3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10568399", "species_10568394", "species_10568392" ], "products": [ "species_10568401" ], "modifiers": [], "additional_components": [ "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "Q95XX0", "WBGene00006708", "species_29420", "Q22743", "WBGene00006414", "WBGene00008588", "Q19214", "WBGene00008588", "species_29420", "Q22743", "WBGene00006414", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "Q95XX0", "WBGene00006708" ] }, "reaction_10551718": { "compartment": "compartment_12045", "id": "reaction_10551718", "reactome": "R-CEL-5362412", "name": "SYVN1 ubiquitinates Hh C-terminal fragments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10551711", "species_10502375" ], "products": [ "species_10551715" ], "modifiers": [ [ "species_10551711", "catalyst" ] ], "additional_components": [ "Q09396", "WBGene00018611", "Q9NF22", "WBGene00013667", "G5EFG0", "WBGene00004759", "Q21997", "WBGene00020109", "P54812", "WBGene00008053", "Q20798", "WBGene00004768", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "Q09396", "WBGene00018611", "Q9NF22", "WBGene00013667", "G5EFG0", "WBGene00004759", "Q21997", "WBGene00020109", "P54812", "WBGene00008053", "Q20798", "WBGene00004768", "Q09396", "WBGene00018611", "Q9NF22", "WBGene00013667", "G5EFG0", "WBGene00004759", "Q21997", "WBGene00020109", "P54812", "WBGene00008053", "Q20798", "WBGene00004768" ] }, "reaction_10552665": { "compartment": "compartment_876", "id": "reaction_10552665", "reactome": "R-CEL-5610727", "name": "GPR161 promotes cAMP production in a G alpha(s)-dependent manner", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592" ], "products": [ "species_111294", "species_30389" ], "modifiers": [ [ "species_10552658", "catalyst" ], [ "species_10552663", "catalyst" ] ], "additional_components": [ "species_114632", "Q09306", "WBGene00006655", "Q20255", "WBGene00022696", "Q18859", "WBGene00016935", "G5EFW7", "WBGene00000906", "G5ECZ4", "WBGene00001118", "P90757", "WBGene00000490" ] }, "reaction_10552670": { "compartment": "compartment_70101", "id": "reaction_10552670", "reactome": "R-CEL-5610735", "name": "NUMB binds ITCH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10524550", "species_10530869" ], "products": [ "species_10552668" ], "modifiers": [], "additional_components": [ "WBGene00003830", "WBGene00007009", "Q9N2Z7", "WBGene00007009", "Q9XTY6", "WBGene00003830" ] }, "reaction_10552682": { "compartment": "compartment_5263232", "id": "reaction_10552682", "reactome": "R-CEL-5610749", "name": "cAMP dissociates PKA, promoting GLI processing", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10552678", "species_30389" ], "products": [ "species_10552680", "species_10552672" ], "modifiers": [], "additional_components": [ "P21137", "WBGene00002189", "P30625", "WBGene00002190", "P30625", "WBGene00002190", "species_30389", "WBGene00002189" ] }, "reaction_10552654": { "compartment": "compartment_18730", "id": "reaction_10552654", "reactome": "R-CEL-5610726", "name": "The IFT-A complex recruits TULP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10552650", "species_10552619" ], "products": [ "species_10552652" ], "modifiers": [], "additional_components": [ "Q20255", "WBGene00022696", "Q18859", "WBGene00016935", "G5EFW7", "WBGene00000906", "G5ECZ4", "WBGene00001118", "P90757", "WBGene00000490", "WBGene00006655", "Q09306", "WBGene00006655", "Q20255", "WBGene00022696", "Q18859", "WBGene00016935", "G5EFW7", "WBGene00000906", "G5ECZ4", "WBGene00001118", "P90757", "WBGene00000490" ] }, "reaction_10554098": { "compartment": "compartment_7660", "id": "reaction_10554098", "reactome": "R-CEL-5635854", "name": "GLI2,3 are degraded by the proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10554096" ], "products": [ "species_10554094", "species_10502318" ], "modifiers": [ [ "species_10512606", "catalyst" ] ], "additional_components": [ "Q23457", "WBGene00004320", "P34568", "WBGene00011815", "Q9NF14", "WBGene00013689", "H2KYJ3", "WBGene00015567", "P41886", "WBGene00018137", "Q94420", "WBGene00003209", "P34371", "WBGene00016803", "Q17391", "WBGene00000838", "Q23457", "WBGene00004320", "P34568", "WBGene00011815", "Q9NF14", "WBGene00013689", "H2KYJ3", "WBGene00015567", "P41886", "WBGene00018137", "Q94420", "WBGene00003209", "P34371", "WBGene00016803", "Q17391", "WBGene00000838", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "Q23237", "WBGene00003949", "P90868", "WBGene00003953", "Q9XUV0", "WBGene00003951", "Q966I8", "WBGene00003947", "O62102", "WBGene00003948", "O16368", "WBGene00004502", "Q18787", "WBGene00004501", "O76371", "WBGene00004505", "P46502", "WBGene00004503", "Q9XTT9", "WBGene00004506", "O17071", "WBGene00004504", "Q18115", "WBGene00004459", "Q20938", "WBGene00004462", "Q19324", "WBGene00004461", "Q22253", "WBGene00004465", "Q9GZH5", "WBGene00004458", "Q04908", "WBGene00004460", "O61742", "WBGene00004466", "O76577", "WBGene00004467", "Q20058", "WBGene00009445", "O44156", "WBGene00003927", "Q20585", "WBGene00004463", "Q27488", "WBGene00003923", "O61792", "WBGene00004464", "Q09583", "WBGene00003928", "Q23449", "WBGene00004468", "Q9N599", "WBGene00003924", "Q10920", "WBGene00016623", "Q95008", "WBGene00003926", "Q95PZ7", "WBGene00013435", "O17586", "WBGene00003922", "Q95005", "WBGene00003925", "P34286", "WBGene00003952", "P91477", "WBGene00003950" ] }, "reaction_10554020": { "compartment": "compartment_261122", "id": "reaction_10554020", "reactome": "R-CEL-5632677", "name": "PTCH is internalized", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10554012" ], "products": [ "species_10554018" ], "modifiers": [], "additional_components": [ "H2L0G5", "WBGene00004210", "Q09614", "WBGene00004208", "Q09614", "WBGene00004208", "H2L0G5", "WBGene00004210" ] }, "reaction_10554105": { "compartment": "compartment_7660", "id": "reaction_10554105", "reactome": "R-CEL-5635856", "name": "SPOP:CUL3:RBX1 ubiquitinates GLI2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502318", "species_10554102" ], "products": [ "species_10554096" ], "modifiers": [ [ "species_10554102", "catalyst" ] ], "additional_components": [ "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "Q23457", "WBGene00004320", "P34568", "WBGene00011815", "Q9NF14", "WBGene00013689", "H2KYJ3", "WBGene00015567", "P41886", "WBGene00018137", "Q94420", "WBGene00003209", "P34371", "WBGene00016803", "Q17391", "WBGene00000838", "Q23457", "WBGene00004320", "P34568", "WBGene00011815", "Q9NF14", "WBGene00013689", "H2KYJ3", "WBGene00015567", "P41886", "WBGene00018137", "Q94420", "WBGene00003209", "P34371", "WBGene00016803", "Q17391", "WBGene00000838", "Q23457", "WBGene00004320", "P34568", "WBGene00011815", "Q9NF14", "WBGene00013689", "H2KYJ3", "WBGene00015567", "P41886", "WBGene00018137", "Q94420", "WBGene00003209", "P34371", "WBGene00016803", "Q17391", "WBGene00000838" ] }, "reaction_10557600": { "compartment": "compartment_70101", "id": "reaction_10557600", "reactome": "R-CEL-5696230", "name": "GSTO1 dimer reduces methylarsonate to methylarsonite", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29450", "species_5696214" ], "products": [ "species_29356", "species_5696224", "species_111745" ], "modifiers": [ [ "species_10511838", "catalyst" ] ], "additional_components": [ "P34345", "WBGene00016204" ] }, "reaction_10511831": { "compartment": "compartment_70101", "id": "reaction_10511831", "reactome": "R-CEL-175987", "name": "NNMT transfers CH3 from AdoMet to PY", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_175973", "species_71284" ], "products": [ "species_175979", "species_71285" ], "modifiers": [ [ "species_10511828", "catalyst" ] ], "additional_components": [ "WBGene00015124" ] }, "reaction_10511767": { "compartment": "compartment_70101", "id": "reaction_10511767", "reactome": "R-CEL-174374", "name": "MTR transfers CH3 from MeCbl to HCYS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_174369", "species_10511760" ], "products": [ "species_174390", "species_10511764" ], "modifiers": [ [ "species_10511760", "catalyst" ] ], "additional_components": [ "species_73524", "Q17574", "WBGene00006510", "species_113596", "species_216785", "CHEBI:28115", "Q09582", "WBGene00010988", "species_216785", "species_3159260", "Q09582", "WBGene00010988", "species_73524", "Q17574", "WBGene00006510", "species_113596", "species_73524", "Q17574", "WBGene00006510", "species_113596", "species_216785", "CHEBI:28115", "Q09582", "WBGene00010988" ] }, "reaction_10511802": { "compartment": "compartment_70101", "id": "reaction_10511802", "reactome": "R-CEL-174401", "name": "AHCY:NAD+ tetramer hydrolyses AdoHcy", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_71285" ], "products": [ "species_83909", "species_174369" ], "modifiers": [ [ "species_10511799", "catalyst" ] ], "additional_components": [ "species_29360", "P27604", "WBGene00019322" ] }, "reaction_10562143": { "compartment": "compartment_70101", "id": "reaction_10562143", "reactome": "R-CEL-6800149", "name": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to MMAIII", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6806829", "species_71284" ], "products": [ "species_6800127", "species_71285" ], "modifiers": [ [ "species_10562137", "catalyst" ] ], "additional_components": [ "O16582", "WBGene00016341", "O45241", "WBGene00007312" ] }, "reaction_10509986": { "compartment": "compartment_70101", "id": "reaction_10509986", "reactome": "R-CEL-159358", "name": "SULT1A3,4 dimers sulfate DA to DAOS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158471", "species_159362" ], "products": [ "species_159352", "species_158466" ], "modifiers": [ [ "species_10509940", "catalyst" ] ], "additional_components": [ "Q9U2Z2", "WBGene00013748" ] }, "reaction_10511970": { "compartment": "compartment_70101", "id": "reaction_10511970", "reactome": "R-CEL-176517", "name": "SULTs transfer (SO4)2- group to PREG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193103", "species_158471" ], "products": [ "species_176665", "species_158466" ], "modifiers": [ [ "species_10511967", "catalyst" ] ], "additional_components": [ "Q9U2Z2", "WBGene00013748" ] }, "reaction_10512002": { "compartment": "compartment_70101", "id": "reaction_10512002", "reactome": "R-CEL-176631", "name": "dehydroepiandrosterone (DHEA) + PAPS => DHEA sulfate + PAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158471", "species_176626" ], "products": [ "species_176496", "species_158466" ], "modifiers": [ [ "species_10511999", "catalyst" ] ], "additional_components": [ "Q9U2Z2", "WBGene00013748" ] }, "reaction_10511777": { "compartment": "compartment_70101", "id": "reaction_10511777", "reactome": "R-CEL-174389", "name": "PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_174370" ], "products": [ "species_29370", "species_158471" ], "modifiers": [ [ "species_10511772", "catalyst" ] ], "additional_components": [ "WBGene00004091" ] }, "reaction_10522868": { "compartment": "compartment_876", "id": "reaction_10522868", "reactome": "R-CEL-427555", "name": "SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_427648" ], "products": [ "species_70106", "species_174375" ], "modifiers": [ [ "species_10522865", "catalyst" ] ], "additional_components": [ "O17951", "WBGene00010789", "G5EEA7", "WBGene00010788", "O45016", "WBGene00020914", "G5EED0", "WBGene00016945", "Q94225", "WBGene00018283", "G5EFB2", "WBGene00013963", "G5EC30", "WBGene00012259" ] }, "reaction_10511780": { "compartment": "compartment_70101", "id": "reaction_10511780", "reactome": "R-CEL-174392", "name": "PAPSS1,2 transfer SO4(2-) group to ATP to form APS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_174375" ], "products": [ "species_111294", "species_174370" ], "modifiers": [ [ "species_10511772", "catalyst" ] ], "additional_components": [ "WBGene00004091" ] }, "reaction_10527852": { "compartment": "compartment_20699", "id": "reaction_10527852", "reactome": "R-CEL-741449", "name": "SLC35B2,3 transport cytosolic PAPS to Golgi lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158471" ], "products": [ "species_741440" ], "modifiers": [ [ "species_10527849", "catalyst" ] ], "additional_components": [ "Q8MXJ9", "WBGene00004206", "Q20787", "WBGene00018827" ] }, "reaction_10511973": { "compartment": "compartment_70101", "id": "reaction_10511973", "reactome": "R-CEL-176521", "name": "beta-estradiol + PAPS => beta-estradiol 3-sulfate + PAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_176619", "species_158471" ], "products": [ "species_176492", "species_158466" ], "modifiers": [ [ "species_10511945", "catalyst" ] ], "additional_components": [ "Q9U2Z2", "WBGene00013748" ] }, "reaction_10569867": { "compartment": "compartment_17963", "id": "reaction_10569867", "reactome": "R-CEL-8953499", "name": "IMPAD1 hydrolyses PAP to AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_742343", "species_2022884" ], "products": [ "species_8851226", "species_8953493" ], "modifiers": [ [ "species_10569864", "catalyst" ], [ "species_8953505", "inhibitor" ] ], "additional_components": [ "species_114632", "Q5ZEQ3", "WBGene00012390" ] }, "reaction_10512011": { "compartment": "compartment_70101", "id": "reaction_10512011", "reactome": "R-CEL-176646", "name": "p-nitrophenol + PAPS => p-nitrophenol sulfate + PAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5695950", "species_158471" ], "products": [ "species_176600", "species_158466" ], "modifiers": [ [ "species_10512008", "catalyst" ] ], "additional_components": [ "Q9U2Z2", "WBGene00013748" ] }, "reaction_10511982": { "compartment": "compartment_70101", "id": "reaction_10511982", "reactome": "R-CEL-176585", "name": "3,5,3'-triiodothyronine + PAPS => 3,5,3'-triiodothyronine 4-sulfate + PAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_176667", "species_158471" ], "products": [ "species_176564", "species_158466" ], "modifiers": [ [ "species_10511979", "catalyst" ] ], "additional_components": [ "Q9U2Z2", "WBGene00013748" ] }, "reaction_10512016": { "compartment": "compartment_70101", "id": "reaction_10512016", "reactome": "R-CEL-176664", "name": "estrone + PAPS => estrone 3-sulfate + PAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_176575", "species_158471" ], "products": [ "species_176501", "species_158466" ], "modifiers": [ [ "species_10512013", "catalyst" ] ], "additional_components": [ "Q9U2Z2", "WBGene00013748" ] }, "reaction_10511985": { "compartment": "compartment_70101", "id": "reaction_10511985", "reactome": "R-CEL-176588", "name": "lithocholate + PAPS => lithocholate sulfate + PAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_176655", "species_158471" ], "products": [ "species_176555", "species_158466" ], "modifiers": [ [ "species_10511949", "catalyst" ] ], "additional_components": [ "Q9U2Z2", "WBGene00013748" ] }, "reaction_10511987": { "compartment": "compartment_70101", "id": "reaction_10511987", "reactome": "R-CEL-176604", "name": "taurolithocholate + PAPS => taurolithocholate sulfate + PAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_176565", "species_158471" ], "products": [ "species_176483", "species_158466" ], "modifiers": [ [ "species_10511949", "catalyst" ] ], "additional_components": [ "Q9U2Z2", "WBGene00013748" ] }, "reaction_10512021": { "compartment": "compartment_70101", "id": "reaction_10512021", "reactome": "R-CEL-176669", "name": "N-hydroxy-2-acetylaminofluorene + PAPS => 2-acetylaminofluorene-N-sulfate + PAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158471", "species_176566" ], "products": [ "species_176500", "species_158466" ], "modifiers": [ [ "species_10512018", "catalyst" ] ], "additional_components": [ "Q9U2Z2", "WBGene00013748" ] }, "reaction_10511958": { "compartment": "compartment_70101", "id": "reaction_10511958", "reactome": "R-CEL-176474", "name": "3,3'-diiodothyronine + PAPS => 3,3'-diiodothyronine 4-sulfate + PAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158471", "species_176486" ], "products": [ "species_176519", "species_158466" ], "modifiers": [ [ "species_10511955", "catalyst" ] ], "additional_components": [ "Q9U2Z2", "WBGene00013748" ] }, "reaction_10509943": { "compartment": "compartment_70101", "id": "reaction_10509943", "reactome": "R-CEL-158468", "name": "SULT1A1 dimer sulfonates PARA to PARA-SO4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158469", "species_158471" ], "products": [ "species_158472", "species_158466" ], "modifiers": [ [ "species_10509940", "catalyst" ] ], "additional_components": [ "Q9U2Z2", "WBGene00013748" ] }, "reaction_10511995": { "compartment": "compartment_70101", "id": "reaction_10511995", "reactome": "R-CEL-176606", "name": "Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_158466" ], "products": [ "species_29372", "species_76577" ], "modifiers": [ [ "species_10511992", "catalyst" ] ], "additional_components": [ "WBGene00044063" ] }, "reaction_10509949": { "compartment": "compartment_70101", "id": "reaction_10509949", "reactome": "R-CEL-158849", "name": "Phenol can form a sulfate conjugate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158858", "species_158471" ], "products": [ "species_158466", "species_158850" ], "modifiers": [ [ "species_10509940", "catalyst" ] ], "additional_components": [ "Q9U2Z2", "WBGene00013748" ] }, "reaction_10511997": { "compartment": "compartment_70101", "id": "reaction_10511997", "reactome": "R-CEL-176609", "name": "cholesterol + PAPS => cholesterol sulfate + PAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_176478", "species_158471" ], "products": [ "species_176618", "species_158466" ], "modifiers": [ [ "species_10511962", "catalyst" ] ], "additional_components": [ "Q9U2Z2", "WBGene00013748" ] }, "reaction_10511965": { "compartment": "compartment_70101", "id": "reaction_10511965", "reactome": "R-CEL-176494", "name": "SULTs transfer (SO4)2- group to 27HCHOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_176617", "species_158471" ], "products": [ "species_176502", "species_158466" ], "modifiers": [ [ "species_10511962", "catalyst" ] ], "additional_components": [ "Q9U2Z2", "WBGene00013748" ] }, "reaction_10509951": { "compartment": "compartment_70101", "id": "reaction_10509951", "reactome": "R-CEL-158860", "name": "SULT1A1 dimer sulfonates NHABP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158847", "species_158471" ], "products": [ "species_158859", "species_158466" ], "modifiers": [ [ "species_10509940", "catalyst" ] ], "additional_components": [ "Q9U2Z2", "WBGene00013748" ] }, "reaction_10510057": { "compartment": "compartment_5460", "id": "reaction_10510057", "reactome": "R-CEL-159566", "name": "benzoyl-CoA + glycine => benzoyl glycine (hippuric acid) + Coenzyme A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_159549", "species_159447" ], "products": [ "species_29374", "species_159564" ], "modifiers": [ [ "species_10510054", "catalyst" ] ], "additional_components": [ "Q95ZT6", "WBGene00018400", "Q22371", "WBGene00018400" ] }, "reaction_10510059": { "compartment": "compartment_5460", "id": "reaction_10510059", "reactome": "R-CEL-159574", "name": "salicylate-CoA + glycine => salicyluric acid + Coenzyme A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_159549", "species_159557" ], "products": [ "species_29374", "species_159572" ], "modifiers": [ [ "species_10510054", "catalyst" ] ], "additional_components": [ "Q95ZT6", "WBGene00018400", "Q22371", "WBGene00018400" ] }, "reaction_10511744": { "compartment": "compartment_12045", "id": "reaction_10511744", "reactome": "R-CEL-174368", "name": "SLC35D1 hexamer transports UDP-GlcA, UDP-GlcNAc from cytosol to endoplasmic reticulum lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158601", "species_162756" ], "products": [ "species_3499326", "species_174384" ], "modifiers": [ [ "species_10511741", "catalyst" ] ], "additional_components": [ "Q18779", "WBGene00005025" ] }, "reaction_10502868": { "compartment": "compartment_70101", "id": "reaction_10502868", "reactome": "R-CEL-70286", "name": "UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29548", "species_29494" ], "products": [ "species_111294", "species_29410" ], "modifiers": [ [ "species_10502865", "catalyst" ] ], "additional_components": [ "Q9XUS5", "WBGene00010665" ] }, "reaction_10511557": { "compartment": "compartment_70101", "id": "reaction_10511557", "reactome": "R-CEL-173597", "name": "UDP-glucose is oxidised to UDP-glucuronate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_29410", "species_29360" ], "products": [ "species_70106", "species_158601", "species_73473" ], "modifiers": [ [ "species_10511554", "catalyst" ] ], "additional_components": [ "Q19905", "WBGene00005022" ] }, "reaction_10557073": { "compartment": "compartment_17957", "id": "reaction_10557073", "reactome": "R-CEL-5693724", "name": "ESD dimer hydrolyses S-FGSH to GSH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113519", "species_5693723" ], "products": [ "species_158543", "species_194712" ], "modifiers": [ [ "species_10557070", "catalyst" ] ], "additional_components": [ "G5EF86", "WBGene00013018" ] }, "reaction_10547222": { "compartment": "compartment_5460", "id": "reaction_10547222", "reactome": "R-CEL-3301943", "name": "GSTK1 dimer transfers GS from GSH to CDNB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1655887", "species_3301954" ], "products": [ "species_3301973", "species_3301969" ], "modifiers": [ [ "species_10547219", "catalyst" ] ], "additional_components": [ "Q18973", "WBGene00017054" ] }, "reaction_10532353": { "compartment": "compartment_70101", "id": "reaction_10532353", "reactome": "R-CEL-1247935", "name": "OPLAH hydrolyses OPRO to L-Glu", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_1247942" ], "products": [ "species_29372", "species_29404", "species_29370" ], "modifiers": [ [ "species_10532350", "catalyst" ] ], "additional_components": [ "A0A9S2", "WBGene00021430" ] }, "reaction_10511734": { "compartment": "compartment_70101", "id": "reaction_10511734", "reactome": "R-CEL-174367", "name": "GCL ligates L-Glu to L-Cys", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29404", "species_111707", "species_113592" ], "products": [ "species_29372", "species_174393", "species_29370" ], "modifiers": [ [ "species_10511731", "catalyst" ] ], "additional_components": [ "A9CZN9", "WBGene00017084", "Q20117", "WBGene00001527" ] }, "reaction_10532343": { "compartment": "compartment_70101", "id": "reaction_10532343", "reactome": "R-CEL-1247922", "name": "GGCT transforms gGluCys to OPRO", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_174393" ], "products": [ "species_111707", "species_1247942" ], "modifiers": [ [ "species_10532340", "catalyst" ] ], "additional_components": [ "Q18596", "WBGene00016629" ] }, "reaction_10568716": { "compartment": "compartment_876", "id": "reaction_10568716", "reactome": "R-CEL-8943279", "name": "GGT dimers hydrolyse GSH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_1247892" ], "products": [ "species_210382", "species_1247934" ], "modifiers": [ [ "species_10552351", "catalyst" ] ], "additional_components": [ "H2L0B7", "WBGene00020590", "O18256", "WBGene00020590", "Q9N5V4", "WBGene00020590", "A0A486WVP7", "WBGene00020590", "B5BM47", "WBGene00020590" ] }, "reaction_10532333": { "compartment": "compartment_70101", "id": "reaction_10532333", "reactome": "R-CEL-1247910", "name": "CNDP2:2Mn2+ dimer hydrolyses CysGly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1247904" ], "products": [ "species_111707", "species_29424" ], "modifiers": [ [ "species_10532330", "catalyst" ] ], "additional_components": [ "O18000", "WBGene00003982", "species_266099" ] }, "reaction_10511790": { "compartment": "compartment_70101", "id": "reaction_10511790", "reactome": "R-CEL-174394", "name": "GSS:Mg2+ dimer synthesizes GSH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_174393", "species_113592", "species_29424" ], "products": [ "species_29372", "species_29370", "species_29450" ], "modifiers": [ [ "species_10511787", "catalyst" ], [ "species_29450", "inhibitor" ] ], "additional_components": [ "species_114632", "Q21549", "WBGene00010941" ] }, "reaction_10511885": { "compartment": "compartment_70101", "id": "reaction_10511885", "reactome": "R-CEL-176054", "name": "GST dimers conjugate GSH with cytosolic substrates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29450", "species_176070" ], "products": [ "species_176049" ], "modifiers": [ [ "species_10511882", "catalyst" ] ], "additional_components": [ "CHEBI:29132", "species_3301954", "CHEBI:30614", "species_3301969", "CHEBI:32639", "CHEBI:34479", "Q18938", "WBGene00001790", "P34277", "WBGene00015337", "D7SFI3", "WBGene00043097", "P34345", "WBGene00016204", "O17234", "WBGene00019636", "O45352", "WBGene00001792", "Q09607", "WBGene00001784", "P10299", "WBGene00001749" ] }, "reaction_10556844": { "compartment": "compartment_70101", "id": "reaction_10556844", "reactome": "R-CEL-5692232", "name": "AKR1A1 oxidises BaPtDHD to BaP-7,8-dione", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29366", "species_5692212" ], "products": [ "species_5692216", "species_29364" ], "modifiers": [ [ "species_10554514", "catalyst" ] ], "additional_components": [ "WBGene00012722" ] }, "reaction_10510318": { "compartment": "compartment_20699", "id": "reaction_10510318", "reactome": "R-CEL-163843", "name": "Furin cleaves pro-GAS6 to GAS6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10510296" ], "products": [ "species_10510310", "species_10510304" ], "modifiers": [ [ "species_10510315", "catalyst" ] ], "additional_components": [ "G5EFX3", "WBGene00013416", "Q9XWD6", "WBGene00000415", "G5EFX3", "WBGene00013416", "Q9XWD6", "WBGene00000415", "G5EFX3", "WBGene00013416", "Q9XWD6", "WBGene00000415", "WBGene00002232" ] }, "reaction_10510298": { "compartment": "compartment_13959", "id": "reaction_10510298", "reactome": "R-CEL-163809", "name": "Gamma-carboxy pro-GAS6 transport from the endoplasmic reticulum to the Golgi apparatus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10510290" ], "products": [ "species_10510296" ], "modifiers": [], "additional_components": [ "G5EFX3", "WBGene00013416", "Q9XWD6", "WBGene00000415", "G5EFX3", "WBGene00013416", "Q9XWD6", "WBGene00000415" ] }, "reaction_10558353": { "compartment": "compartment_70101", "id": "reaction_10558353", "reactome": "R-CEL-6788867", "name": "FN3K phosphorylates ketosamines", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_6788868" ], "products": [ "species_29370", "species_6788848" ], "modifiers": [ [ "species_10558348", "catalyst" ] ], "additional_components": [ "CHEBI:87176", "CHEBI:24103", "CHEBI:87177", "CHEBI:87180", "CHEBI:87178", "CHEBI:87179", "WBGene00013802" ] }, "reaction_10516057": { "compartment": "compartment_70101", "id": "reaction_10516057", "reactome": "R-CEL-204662", "name": "DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29368", "species_10516005", "species_73473" ], "products": [ "species_10516047", "species_29356", "species_29360" ], "modifiers": [ [ "species_10516054", "catalyst" ] ], "additional_components": [ "Q20751", "WBGene00002065", "P34563", "WBGene00002064", "P34563", "WBGene00002064", "Q20751", "WBGene00002065", "Q17949", "WBGene00007555", "species_113531" ] }, "reaction_10516029": { "compartment": "compartment_70101", "id": "reaction_10516029", "reactome": "R-CEL-204617", "name": "DHPS tetramer synthesizes EIF5A and spermidine from Dhp-K50-EIF5A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_204628", "species_10516005", "species_73473" ], "products": [ "species_204635", "species_10516019", "species_29360" ], "modifiers": [ [ "species_10516026", "catalyst" ] ], "additional_components": [ "Q20751", "WBGene00002065", "P34563", "WBGene00002064", "P34563", "WBGene00002064", "Q20751", "WBGene00002065", "Q9XXJ0", "WBGene00012460" ] }, "reaction_10551593": { "compartment": "compartment_70101", "id": "reaction_10551593", "reactome": "R-CEL-5358484", "name": "DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10551582", "species_71284" ], "products": [ "species_71285", "species_10551585" ], "modifiers": [ [ "species_10551590", "catalyst" ] ], "additional_components": [ "WBGene00001167", "WBGene00001167", "WBGene00007194" ] }, "reaction_10551579": { "compartment": "compartment_70101", "id": "reaction_10551579", "reactome": "R-CEL-5358475", "name": "DPH6 ligates ammonium to diphthine-EEF2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10551571", "species_31633" ], "products": [ "species_111294", "species_10509919", "species_76577" ], "modifiers": [ [ "species_10551576", "catalyst" ] ], "additional_components": [ "WBGene00001167", "WBGene00001167", "WBGene00017087" ] }, "reaction_10551615": { "compartment": "compartment_70101", "id": "reaction_10551615", "reactome": "R-CEL-5358494", "name": "DPH2 transfers a 3-amino-3-carboxypropyl group from AdoMet to residue 715 of nascent EEF2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10551595", "species_71284" ], "products": [ "species_10551582", "species_353106" ], "modifiers": [ [ "species_10551612", "catalyst" ] ], "additional_components": [ "WBGene00001167", "WBGene00001167", "P49958", "WBGene00007576", "Q09454", "WBGene00007488", "Q21102", "WBGene00010484" ] }, "reaction_10558335": { "compartment": "compartment_12045", "id": "reaction_10558335", "reactome": "R-CEL-6788650", "name": "ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6788753", "species_71284" ], "products": [ "species_71285", "species_6788758" ], "modifiers": [ [ "species_10558332", "catalyst" ] ], "additional_components": [ "species_216785", "P91402", "WBGene00019710" ] }, "reaction_10558351": { "compartment": "compartment_70101", "id": "reaction_10558351", "reactome": "R-CEL-6788855", "name": "FN3KRP phosphorylates PsiAm, RibAm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_6788865" ], "products": [ "species_6788858", "species_29370" ], "modifiers": [ [ "species_10558348", "catalyst" ] ], "additional_components": [ "CHEBI:87176", "CHEBI:87177", "CHEBI:87180", "CHEBI:87179", "WBGene00013802" ] }, "reaction_10570837": { "compartment": "compartment_876", "id": "reaction_10570837", "reactome": "R-CEL-9010872", "name": "SLIT2 binds Dystroglycan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10519315", "species_10570833" ], "products": [ "species_10570835" ], "modifiers": [], "additional_components": [ "WBGene00004854", "O61756", "WBGene00018943", "Q22629", "WBGene00000961", "O61756", "WBGene00018943", "Q22629", "WBGene00000961", "G5EFX6", "WBGene00004854" ] }, "reaction_10564693": { "compartment": "compartment_20699", "id": "reaction_10564693", "reactome": "R-CEL-8848484", "name": "PLA2s hydrolyze phospholipids at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_429785", "species_29356" ], "products": [ "species_6814303", "species_8848483" ], "modifiers": [ [ "species_10534904", "catalyst" ] ], "additional_components": [ "WBGene00016661" ] }, "reaction_10564918": { "compartment": "compartment_12045", "id": "reaction_10564918", "reactome": "R-CEL-8849353", "name": "Dynein drives COPI-independent retrograde traffic from the Golgi to the ER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10564872" ], "products": [ "species_29370", "species_10564859", "species_10553033", "species_10564898" ], "modifiers": [ [ "species_8848483", "catalyst" ], [ "species_10564916", "catalyst" ] ], "additional_components": [ "Q19020", "WBGene00000962", "O45087", "WBGene00015927", "Q65XS9", "WBGene00043067", "A0AAC1", "WBGene00012424", "Q7YTJ8", "WBGene00012425", "Q21557", "WBGene00010888", "Q22799", "WBGene00001005", "G5ED34", "WBGene00001007", "species_29420", "species_29438", "Q9NA98", "WBGene00013168", "P34685", "WBGene00000292", "P34686", "WBGene00000293", "Q18194", "WBGene00016124", "Q9N4I1", "WBGene00022118", "Q9N3F1", "WBGene00021827", "Q9GYR2", "WBGene00016793", "Q09248", "WBGene00001018", "E2JKZ0", "WBGene00001017", "V6CJ04", "WBGene00016611", "Q22782", "WBGene00004270", "P34213", "WBGene00004269", "Q8I136", "WBGene00001629", "O61394", "WBGene00001631", "V6CJ04", "WBGene00016611", "Q19020", "WBGene00000962", "O45087", "WBGene00015927", "Q65XS9", "WBGene00043067", "A0AAC1", "WBGene00012424", "Q7YTJ8", "WBGene00012425", "Q21557", "WBGene00010888", "Q22799", "WBGene00001005", "G5ED34", "WBGene00001007", "species_29420", "species_29438", "Q9NA98", "WBGene00013168", "P34685", "WBGene00000292", "P34686", "WBGene00000293", "Q18194", "WBGene00016124", "Q9N4I1", "WBGene00022118", "Q9N3F1", "WBGene00021827", "Q9GYR2", "WBGene00016793", "Q09248", "WBGene00001018", "E2JKZ0", "WBGene00001017", "O61394", "WBGene00001631", "Q8I136", "WBGene00001629", "P34213", "WBGene00004269", "Q22782", "WBGene00004270", "species_29438", "Q8MXS1", "WBGene00004277", "species_29438", "Q93538", "WBGene00004317", "Q22670", "WBGene00004318" ] }, "reaction_10564982": { "compartment": "compartment_12045", "id": "reaction_10564982", "reactome": "R-CEL-8850040", "name": "RAB3GAP1:RAB3GAP2 recruits RAB18:GCDP to ER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10564910", "species_10564978" ], "products": [ "species_10564980" ], "modifiers": [], "additional_components": [ "Q93538", "WBGene00004317", "Q22670", "WBGene00004318", "Q8MXS1", "WBGene00004277", "species_29420", "Q8MXS1", "WBGene00004277", "species_29420", "Q93538", "WBGene00004317", "Q22670", "WBGene00004318" ] }, "reaction_10564985": { "compartment": "compartment_12045", "id": "reaction_10564985", "reactome": "R-CEL-8850041", "name": "RAB3GAP1:RAB3GAP2 promotes nucleotide exchange on RAB18", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10564980" ], "products": [ "species_29420", "species_10564916" ], "modifiers": [ [ "species_10564980", "catalyst" ] ], "additional_components": [ "Q8MXS1", "WBGene00004277", "species_29420", "Q93538", "WBGene00004317", "Q22670", "WBGene00004318", "Q8MXS1", "WBGene00004277", "species_29438", "Q93538", "WBGene00004317", "Q22670", "WBGene00004318", "Q8MXS1", "WBGene00004277", "species_29420", "Q93538", "WBGene00004317", "Q22670", "WBGene00004318" ] }, "reaction_10564874": { "compartment": "compartment_20699", "id": "reaction_10564874", "reactome": "R-CEL-8849350", "name": "RAB6:GTP displaces PAFAH1B1 from dynein:dynactin complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10564861", "species_10564870" ], "products": [ "species_10564872", "species_10564868" ], "modifiers": [], "additional_components": [ "V6CJ04", "WBGene00016611", "Q22782", "WBGene00004270", "P34213", "WBGene00004269", "species_29438", "Q8I136", "WBGene00001629", "O61394", "WBGene00001631", "Q9NDC9", "WBGene00003047", "Q19020", "WBGene00000962", "O45087", "WBGene00015927", "Q65XS9", "WBGene00043067", "A0AAC1", "WBGene00012424", "Q7YTJ8", "WBGene00012425", "Q21557", "WBGene00010888", "Q22799", "WBGene00001005", "G5ED34", "WBGene00001007", "species_29420", "species_29438", "Q9NA98", "WBGene00013168", "P34685", "WBGene00000292", "P34686", "WBGene00000293", "Q18194", "WBGene00016124", "Q9N4I1", "WBGene00022118", "Q9N3F1", "WBGene00021827", "Q9GYR2", "WBGene00016793", "Q09248", "WBGene00001018", "E2JKZ0", "WBGene00001017", "Q19020", "WBGene00000962", "O45087", "WBGene00015927", "Q65XS9", "WBGene00043067", "A0AAC1", "WBGene00012424", "Q7YTJ8", "WBGene00012425", "Q21557", "WBGene00010888", "Q22799", "WBGene00001005", "G5ED34", "WBGene00001007", "species_29420", "species_29438", "Q9NA98", "WBGene00013168", "P34685", "WBGene00000292", "P34686", "WBGene00000293", "Q18194", "WBGene00016124", "Q9N4I1", "WBGene00022118", "Q9N3F1", "WBGene00021827", "Q9GYR2", "WBGene00016793", "Q09248", "WBGene00001018", "E2JKZ0", "WBGene00001017", "V6CJ04", "WBGene00016611", "Q22782", "WBGene00004270", "P34213", "WBGene00004269", "Q8I136", "WBGene00001629", "O61394", "WBGene00001631", "WBGene00003047" ] }, "reaction_10564863": { "compartment": "compartment_20699", "id": "reaction_10564863", "reactome": "R-CEL-8849348", "name": "RAB6:GTP and BICD homodimers bind COPI-independent Golgi-to-ER retrograde cargo", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10564846", "species_10564844", "species_10564859" ], "products": [ "species_10564861" ], "modifiers": [], "additional_components": [ "Q8I136", "WBGene00001629", "O61394", "WBGene00001631", "Q22782", "WBGene00004270", "P34213", "WBGene00004269", "species_29438", "V6CJ04", "WBGene00016611", "V6CJ04", "WBGene00016611", "Q22782", "WBGene00004270", "P34213", "WBGene00004269", "species_29438", "Q8I136", "WBGene00001629", "O61394", "WBGene00001631" ] }, "reaction_10563841": { "compartment": "compartment_20699", "id": "reaction_10563841", "reactome": "R-CEL-6811414", "name": "GBF1 stimulates nucleotide exchange on ARF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10563830" ], "products": [ "species_29420", "species_10563834" ], "modifiers": [ [ "species_10563830", "catalyst" ] ], "additional_components": [ "G5EGS5", "WBGene00007703", "Q9UAQ6", "WBGene00004266", "species_29438", "Q94231", "WBGene00000190", "species_29420", "G5EGS5", "WBGene00007703", "Q9UAQ6", "WBGene00004266", "species_29438", "Q94231", "WBGene00000190", "G5EGS5", "WBGene00007703", "Q9UAQ6", "WBGene00004266", "species_29438", "Q94231", "WBGene00000190", "species_29420" ] }, "reaction_10563843": { "compartment": "compartment_20699", "id": "reaction_10563843", "reactome": "R-CEL-6811415", "name": "RAB:GTP recruits GBF1 to the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10563535", "species_10563179" ], "products": [ "species_10563828" ], "modifiers": [], "additional_components": [ "Q9UAQ6", "WBGene00004266", "species_29438", "WBGene00007703", "G5EGS5", "WBGene00007703", "Q9UAQ6", "WBGene00004266", "species_29438" ] }, "reaction_10563890": { "compartment": "compartment_12045", "id": "reaction_10563890", "reactome": "R-CEL-6811422", "name": "NSF ATPase activity dissociates cis-SNARE at the ER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10563887", "species_113592" ], "products": [ "species_29372", "species_10563883", "species_10515624", "species_10563878", "species_10557345", "species_10557329", "species_10563873" ], "modifiers": [ [ "species_10563887", "catalyst" ] ], "additional_components": [ "Q18921", "WBGene00017016", "Q94392", "WBGene00003818", "Q94241", "WBGene00018853", "C0Z1Y7", "WBGene00018239", "O76413", "WBGene00020425", "Q9N598", "WBGene00022460", "WBGene00022460", "WBGene00018853", "WBGene00020425", "Q18921", "WBGene00017016", "Q94392", "WBGene00003818", "WBGene00018239", "Q18921", "WBGene00017016", "Q94392", "WBGene00003818", "Q94241", "WBGene00018853", "C0Z1Y7", "WBGene00018239", "O76413", "WBGene00020425", "Q9N598", "WBGene00022460" ] }, "reaction_10563832": { "compartment": "compartment_20699", "id": "reaction_10563832", "reactome": "R-CEL-6811411", "name": "GBF1 recruits ARF:GDP to the Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10563191", "species_10563828" ], "products": [ "species_10563830" ], "modifiers": [], "additional_components": [ "Q94231", "WBGene00000190", "species_29420", "G5EGS5", "WBGene00007703", "Q9UAQ6", "WBGene00004266", "species_29438", "G5EGS5", "WBGene00007703", "Q9UAQ6", "WBGene00004266", "species_29438", "Q94231", "WBGene00000190", "species_29420" ] }, "reaction_10563898": { "compartment": "compartment_12045", "id": "reaction_10563898", "reactome": "R-CEL-6811425", "name": "NSF and SNAPs bind cis-SNARE at the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10563896", "species_10557329", "species_10557345" ], "products": [ "species_10563887" ], "modifiers": [], "additional_components": [ "Q94241", "WBGene00018853", "C0Z1Y7", "WBGene00018239", "O76413", "WBGene00020425", "Q9N598", "WBGene00022460", "Q94392", "WBGene00003818", "Q18921", "WBGene00017016", "Q18921", "WBGene00017016", "Q94392", "WBGene00003818", "Q94241", "WBGene00018853", "C0Z1Y7", "WBGene00018239", "O76413", "WBGene00020425", "Q9N598", "WBGene00022460" ] }, "reaction_10563868": { "compartment": "compartment_20699", "id": "reaction_10563868", "reactome": "R-CEL-6811418", "name": "ARFGAPs stimulate ARF GTPase activity at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10563853" ], "products": [ "species_10563262", "species_10563179", "species_10563865", "species_10563191" ], "modifiers": [ [ "species_10563853", "catalyst" ] ], "additional_components": [ "Q94241", "WBGene00018853", "Q09473", "WBGene00016195", "P48583", "WBGene00001331", "Q18864", "WBGene00004788", "Q20546", "WBGene00009829", "A4F319", "WBGene00011606", "Q9U1Z4", "WBGene00013360", "O17528", "WBGene00004766", "O44738", "WBGene00019003", "G5EGS5", "WBGene00007703", "Q9UAQ6", "WBGene00004266", "species_29438", "Q94231", "WBGene00000190", "Q09236", "WBGene00015734", "Q22498", "WBGene00011775", "Q9TYL9", "WBGene00021292", "O17901", "WBGene00010333", "Q20168", "WBGene00009542", "O62246", "WBGene00009732", "Q9N4H7", "WBGene00022119", "Q09531", "WBGene00017217", "P90904", "WBGene00010500", "Q09531", "WBGene00017217", "P90904", "WBGene00010500", "WBGene00007703", "Q94241", "WBGene00018853", "Q9UAQ6", "WBGene00004266", "species_29438", "P48583", "WBGene00001331", "Q09473", "WBGene00016195", "Q18864", "WBGene00004788", "Q20546", "WBGene00009829", "Q9U1Z4", "WBGene00013360", "A4F319", "WBGene00011606", "O17528", "WBGene00004766", "O44738", "WBGene00019003", "Q09236", "WBGene00015734", "Q9TYL9", "WBGene00021292", "Q22498", "WBGene00011775", "O17901", "WBGene00010333", "Q9N4H7", "WBGene00022119", "Q20168", "WBGene00009542", "O62246", "WBGene00009732", "Q94231", "WBGene00000190", "species_29420", "Q94241", "WBGene00018853", "Q09473", "WBGene00016195", "P48583", "WBGene00001331", "Q18864", "WBGene00004788", "Q20546", "WBGene00009829", "A4F319", "WBGene00011606", "Q9U1Z4", "WBGene00013360", "O17528", "WBGene00004766", "O44738", "WBGene00019003", "G5EGS5", "WBGene00007703", "Q9UAQ6", "WBGene00004266", "species_29438", "Q94231", "WBGene00000190", "Q09236", "WBGene00015734", "Q22498", "WBGene00011775", "Q9TYL9", "WBGene00021292", "O17901", "WBGene00010333", "Q20168", "WBGene00009542", "O62246", "WBGene00009732", "Q9N4H7", "WBGene00022119", "Q09531", "WBGene00017217", "P90904", "WBGene00010500" ] }, "reaction_10563855": { "compartment": "compartment_20699", "id": "reaction_10563855", "reactome": "R-CEL-6811417", "name": "ARFGAP, cargo, vSNARES and p24 proteins bind COPI vesicles at Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10563262", "species_10563836", "species_10563565", "species_10563851", "species_10563845" ], "products": [ "species_10563853" ], "modifiers": [], "additional_components": [ "Q09531", "WBGene00017217", "P90904", "WBGene00010500", "G5EGS5", "WBGene00007703", "Q9UAQ6", "WBGene00004266", "species_29438", "Q94231", "WBGene00000190", "Q09236", "WBGene00015734", "Q22498", "WBGene00011775", "Q9TYL9", "WBGene00021292", "O17901", "WBGene00010333", "Q20168", "WBGene00009542", "O62246", "WBGene00009732", "Q9N4H7", "WBGene00022119", "O44738", "WBGene00019003", "Q20546", "WBGene00009829", "A4F319", "WBGene00011606", "Q9U1Z4", "WBGene00013360", "O17528", "WBGene00004766", "Q09473", "WBGene00016195", "P48583", "WBGene00001331", "Q18864", "WBGene00004788", "Q20546", "WBGene00009829", "A4F319", "WBGene00011606", "Q9U1Z4", "WBGene00013360", "O17528", "WBGene00004766", "WBGene00018853", "Q94241", "WBGene00018853", "Q09473", "WBGene00016195", "P48583", "WBGene00001331", "Q18864", "WBGene00004788", "Q20546", "WBGene00009829", "A4F319", "WBGene00011606", "Q9U1Z4", "WBGene00013360", "O17528", "WBGene00004766", "O44738", "WBGene00019003", "G5EGS5", "WBGene00007703", "Q9UAQ6", "WBGene00004266", "species_29438", "Q94231", "WBGene00000190", "Q09236", "WBGene00015734", "Q22498", "WBGene00011775", "Q9TYL9", "WBGene00021292", "O17901", "WBGene00010333", "Q20168", "WBGene00009542", "O62246", "WBGene00009732", "Q9N4H7", "WBGene00022119", "Q09531", "WBGene00017217", "P90904", "WBGene00010500" ] }, "reaction_10563838": { "compartment": "compartment_20699", "id": "reaction_10563838", "reactome": "R-CEL-6811412", "name": "Active ARF recruits coatomer to the Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10563244", "species_10563834" ], "products": [ "species_10563836" ], "modifiers": [], "additional_components": [ "Q09236", "WBGene00015734", "Q22498", "WBGene00011775", "Q9TYL9", "WBGene00021292", "O17901", "WBGene00010333", "Q20168", "WBGene00009542", "O62246", "WBGene00009732", "Q9N4H7", "WBGene00022119", "G5EGS5", "WBGene00007703", "Q9UAQ6", "WBGene00004266", "species_29438", "Q94231", "WBGene00000190", "G5EGS5", "WBGene00007703", "Q9UAQ6", "WBGene00004266", "species_29438", "Q94231", "WBGene00000190", "Q09236", "WBGene00015734", "Q22498", "WBGene00011775", "Q9TYL9", "WBGene00021292", "O17901", "WBGene00010333", "Q20168", "WBGene00009542", "O62246", "WBGene00009732", "Q9N4H7", "WBGene00022119" ] }, "reaction_10563982": { "compartment": "compartment_12045", "id": "reaction_10563982", "reactome": "R-CEL-6811427", "name": "COPI vesicle uncoating at the ER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10563980" ], "products": [ "species_10557214", "species_10563244", "species_10563978", "species_10563896", "species_10563936" ], "modifiers": [], "additional_components": [ "Q20546", "WBGene00009829", "O17528", "WBGene00004766", "O44738", "WBGene00019003", "A4F319", "WBGene00011606", "Q9U1Z4", "WBGene00013360", "Q94241", "WBGene00018853", "Q19642", "WBGene00017643", "P90841", "WBGene00008990", "Q9N4H7", "WBGene00022119", "Q20168", "WBGene00009542", "O62246", "WBGene00009732", "Q22498", "WBGene00011775", "O17901", "WBGene00010333", "Q09236", "WBGene00015734", "Q9TYL9", "WBGene00021292", "P48583", "WBGene00001331", "Q09473", "WBGene00016195", "Q18864", "WBGene00004788", "C0Z1Y7", "WBGene00018239", "O76413", "WBGene00020425", "Q9N598", "WBGene00022460", "Q9UAQ6", "WBGene00004266", "species_29438", "Q9UAQ6", "WBGene00004266", "species_29420", "Q09236", "WBGene00015734", "Q22498", "WBGene00011775", "Q9TYL9", "WBGene00021292", "O17901", "WBGene00010333", "Q20168", "WBGene00009542", "O62246", "WBGene00009732", "Q9N4H7", "WBGene00022119", "P48583", "WBGene00001331", "Q09473", "WBGene00016195", "Q20546", "WBGene00009829", "O17528", "WBGene00004766", "Q18864", "WBGene00004788", "A4F319", "WBGene00011606", "Q9U1Z4", "WBGene00013360", "Q94241", "WBGene00018853", "C0Z1Y7", "WBGene00018239", "O76413", "WBGene00020425", "Q9N598", "WBGene00022460", "Q20546", "WBGene00009829", "O17528", "WBGene00004766", "O44738", "WBGene00019003", "A4F319", "WBGene00011606", "Q9U1Z4", "WBGene00013360" ] }, "reaction_10555089": { "compartment": "compartment_876", "id": "reaction_10555089", "reactome": "R-CEL-5672980", "name": "Dissociation of RAS:RAF complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10555069" ], "products": [ "species_10555065", "species_10555030", "species_10508583", "species_10555044" ], "modifiers": [], "additional_components": [ "P39745", "WBGene00003401", "Q10664", "WBGene00003186", "Q07292", "WBGene00003030", "species_29438", "P22981", "WBGene00002335", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "Q10664", "WBGene00003186", "WBGene00003401", "Q07292", "WBGene00003030", "species_29438", "P22981", "WBGene00002335", "P41932", "WBGene00003920", "Q20655", "WBGene00001502" ] }, "reaction_10572917": { "compartment": "compartment_876", "id": "reaction_10572917", "reactome": "R-CEL-9657599", "name": "Dual mechanism MAP2K inhibitors bind MAP2Ks", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9657567", "species_10555042" ], "products": [ "species_10555074" ], "modifiers": [], "additional_components": [ "Q10664", "WBGene00003186", "Q07292", "WBGene00003030", "species_29438", "P22981", "WBGene00002335", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "P39745", "WBGene00003401", "Q10664", "WBGene00003186", "Q07292", "WBGene00003030", "species_29438", "P22981", "WBGene00002335", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "P39745", "WBGene00003401" ] }, "reaction_10555156": { "compartment": "compartment_20699", "id": "reaction_10555156", "reactome": "R-CEL-5674366", "name": "IL17RD binds p-2S MAP2Ks and MAPKs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508575", "species_10555065", "species_10555152" ], "products": [ "species_10555154" ], "modifiers": [], "additional_components": [ "WBGene00003401", "Q10664", "WBGene00003186", "Q10128", "WBGene00018960", "Q9NA64", "WBGene00013415", "Q10128", "WBGene00018960", "Q9NA64", "WBGene00013415", "Q10664", "WBGene00003186", "P39745", "WBGene00003401" ] }, "reaction_10572919": { "compartment": "compartment_876", "id": "reaction_10572919", "reactome": "R-CEL-9657603", "name": "Dual mechanism MAPK inhibitors bind MAPKs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10555067", "species_9657570" ], "products": [ "species_10555076" ], "modifiers": [], "additional_components": [ "Q10664", "WBGene00003186", "Q07292", "WBGene00003030", "species_29438", "P22981", "WBGene00002335", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "P39745", "WBGene00003401", "Q10664", "WBGene00003186", "Q07292", "WBGene00003030", "species_29438", "P22981", "WBGene00002335", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "P39745", "WBGene00003401" ] }, "reaction_10555078": { "compartment": "compartment_876", "id": "reaction_10555078", "reactome": "R-CEL-5672973", "name": "MAP2Ks phosphorylate MAPKs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10555067", "species_113592" ], "products": [ "species_10555069", "species_29370" ], "modifiers": [ [ "species_10555067", "catalyst" ], [ "species_10555074", "inhibitor" ], [ "species_10555076", "inhibitor" ], [ "species_10555072", "inhibitor" ] ], "additional_components": [ "Q10664", "WBGene00003186", "Q07292", "WBGene00003030", "species_29438", "P22981", "WBGene00002335", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "P39745", "WBGene00003401", "P39745", "WBGene00003401", "Q10664", "WBGene00003186", "Q07292", "WBGene00003030", "species_29438", "P22981", "WBGene00002335", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "Q10664", "WBGene00003186", "Q07292", "WBGene00003030", "species_29438", "P22981", "WBGene00002335", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "P39745", "WBGene00003401", "Q10664", "WBGene00003186", "Q07292", "WBGene00003030", "species_29438", "P22981", "WBGene00002335", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "P39745", "WBGene00003401", "Q10664", "WBGene00003186", "Q07292", "WBGene00003030", "species_29438", "P22981", "WBGene00002335", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "P39745", "WBGene00003401", "Q10664", "WBGene00003186", "Q07292", "WBGene00003030", "species_29438", "P22981", "WBGene00002335", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "P39745", "WBGene00003401" ] }, "reaction_10572921": { "compartment": "compartment_876", "id": "reaction_10572921", "reactome": "R-CEL-9657606", "name": "Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10555067", "species_9657574" ], "products": [ "species_10555072" ], "modifiers": [], "additional_components": [ "Q10664", "WBGene00003186", "Q07292", "WBGene00003030", "species_29438", "P22981", "WBGene00002335", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "P39745", "WBGene00003401", "Q10664", "WBGene00003186", "Q07292", "WBGene00003030", "species_29438", "P22981", "WBGene00002335", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "P39745", "WBGene00003401" ] }, "reaction_10555129": { "compartment": "compartment_74700", "id": "reaction_10555129", "reactome": "R-CEL-5674130", "name": "MAP2Ks and MAPKs are phosphorylated at the endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10555125" ], "products": [ "species_29370", "species_10555127" ], "modifiers": [], "additional_components": [ "Q19986", "WBGene00018014", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "Q10664", "WBGene00003186", "Q07292", "WBGene00003030", "P39745", "WBGene00003401", "Q19986", "WBGene00018014", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "Q07292", "WBGene00003030", "P39745", "WBGene00003401", "Q10664", "WBGene00003186" ] }, "reaction_10555161": { "compartment": "compartment_20699", "id": "reaction_10555161", "reactome": "R-CEL-5674373", "name": "MAP2Ks phosphorylate MAPK at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10555154" ], "products": [ "species_29370", "species_10555158" ], "modifiers": [ [ "species_10555154", "catalyst" ] ], "additional_components": [ "Q10128", "WBGene00018960", "Q9NA64", "WBGene00013415", "Q10664", "WBGene00003186", "P39745", "WBGene00003401", "Q10128", "WBGene00018960", "Q9NA64", "WBGene00013415", "P39745", "WBGene00003401", "Q10664", "WBGene00003186", "Q10128", "WBGene00018960", "Q9NA64", "WBGene00013415", "Q10664", "WBGene00003186", "P39745", "WBGene00003401" ] }, "reaction_10555131": { "compartment": "compartment_74700", "id": "reaction_10555131", "reactome": "R-CEL-5674132", "name": "WDR83:LAMTOR2:LAMTOR3 binds MAPK components", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508575", "species_10555123", "species_10555040", "species_10555121" ], "products": [ "species_10555125" ], "modifiers": [], "additional_components": [ "WBGene00003401", "Q07292", "WBGene00003030", "Q10664", "WBGene00003186", "Q19986", "WBGene00018014", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "Q19986", "WBGene00018014", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "Q10664", "WBGene00003186", "Q07292", "WBGene00003030", "P39745", "WBGene00003401" ] }, "reaction_10555053": { "compartment": "compartment_876", "id": "reaction_10555053", "reactome": "R-CEL-5672972", "name": "MAP2Ks and MAPKs bind to the activated RAF complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508575", "species_10555006", "species_10555030", "species_10555040" ], "products": [ "species_10555042" ], "modifiers": [ [ "species_10555051", "inhibitor" ] ], "additional_components": [ "WBGene00003401", "Q07292", "WBGene00003030", "species_29438", "P22981", "WBGene00002335", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "Q10664", "WBGene00003186", "Q10664", "WBGene00003186", "Q07292", "WBGene00003030", "species_29438", "P22981", "WBGene00002335", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "P39745", "WBGene00003401", "Q07292", "WBGene00003030", "species_29438", "P22981", "WBGene00002335", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "O16264", "WBGene00018218" ] }, "reaction_10572925": { "compartment": "compartment_876", "id": "reaction_10572925", "reactome": "R-CEL-9657608", "name": "Single mechanism MAPK inhibitors bind phosphorylated MAPK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10555069", "species_9657577" ], "products": [ "species_10572923" ], "modifiers": [], "additional_components": [ "P39745", "WBGene00003401", "Q10664", "WBGene00003186", "Q07292", "WBGene00003030", "species_29438", "P22981", "WBGene00002335", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "P39745", "WBGene00003401", "Q10664", "WBGene00003186", "Q07292", "WBGene00003030", "species_29438", "P22981", "WBGene00002335", "P41932", "WBGene00003920", "Q20655", "WBGene00001502" ] }, "reaction_10555086": { "compartment": "compartment_876", "id": "reaction_10555086", "reactome": "R-CEL-5672978", "name": "RAF phosphorylates MAP2K dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10555042" ], "products": [ "species_10555067", "species_29370" ], "modifiers": [ [ "species_10555042", "catalyst" ], [ "species_10555084", "inhibitor" ], [ "species_10555074", "inhibitor" ] ], "additional_components": [ "Q10664", "WBGene00003186", "Q07292", "WBGene00003030", "species_29438", "P22981", "WBGene00002335", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "P39745", "WBGene00003401", "Q10664", "WBGene00003186", "Q07292", "WBGene00003030", "species_29438", "P22981", "WBGene00002335", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "P39745", "WBGene00003401", "Q10664", "WBGene00003186", "Q07292", "WBGene00003030", "species_29438", "P22981", "WBGene00002335", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "P39745", "WBGene00003401", "Q07292", "WBGene00003030", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "species_29438", "P22981", "WBGene00002335", "Q10664", "WBGene00003186", "Q07292", "WBGene00003030", "species_29438", "P22981", "WBGene00002335", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "P39745", "WBGene00003401" ] }, "reaction_10534928": { "compartment": "compartment_12045", "id": "reaction_10534928", "reactome": "R-CEL-1482900", "name": "PG is hydrolyzed to 1-acyl LPG by PLA2[1]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1483256", "species_29356" ], "products": [ "species_1524021", "species_1498740" ], "modifiers": [ [ "species_10534783", "catalyst" ] ], "additional_components": [ "O16654", "WBGene00044468", "Q17790", "WBGene00044468", "Q3V5J7", "WBGene00044468" ] }, "reaction_10535857": { "compartment": "compartment_984", "id": "reaction_10535857", "reactome": "R-CEL-1602368", "name": "PG is hydrolyzed to 1-acyl LPG by PLA2[16]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_1602402" ], "products": [ "species_1602415", "species_1602366" ], "modifiers": [ [ "species_10535837", "catalyst" ], [ "species_10535855", "inhibitor" ] ], "additional_components": [ "species_74016", "Q17790", "WBGene00044468", "O16654", "WBGene00044468", "Q3V5J7", "WBGene00044468", "Q18339", "WBGene00016288", "G4RY15", "WBGene00015631", "P34472", "WBGene00010228", "Q22591", "WBGene00020585" ] }, "reaction_10534930": { "compartment": "compartment_12045", "id": "reaction_10534930", "reactome": "R-CEL-1482907", "name": "PG is hydrolyzed to 1-acyl LPG by PLA2G2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1483256", "species_29356" ], "products": [ "species_1524021", "species_1498740" ], "modifiers": [ [ "species_10534852", "catalyst" ] ], "additional_components": [ "Q3V5J7", "WBGene00044468", "O16654", "WBGene00044468", "Q17790", "WBGene00044468", "species_74016" ] }, "reaction_10534742": { "compartment": "compartment_12045", "id": "reaction_10534742", "reactome": "R-CEL-1482539", "name": "1-acyl LPG is acylated to PG by LPGAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500578", "species_1498740" ], "products": [ "species_1483256", "species_76194" ], "modifiers": [ [ "species_10534739", "catalyst" ] ], "additional_components": [ "WBGene00019465" ] }, "reaction_10534792": { "compartment": "compartment_12045", "id": "reaction_10534792", "reactome": "R-CEL-1482635", "name": "2-acyl LPG is acylated to PG by LPGAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1498730", "species_1500578" ], "products": [ "species_1483256", "species_76194" ], "modifiers": [ [ "species_10534739", "catalyst" ] ], "additional_components": [ "WBGene00019465" ] }, "reaction_10534858": { "compartment": "compartment_70616", "id": "reaction_10534858", "reactome": "R-CEL-1482689", "name": "1-acyl LPG is acylated to PG by CRLS1 (IM)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524027", "species_1524038" ], "products": [ "species_29374", "species_1524042" ], "modifiers": [ [ "species_10534747", "catalyst" ] ], "additional_components": [ "WBGene00017763" ] }, "reaction_10534750": { "compartment": "compartment_70616", "id": "reaction_10534750", "reactome": "R-CEL-1482546", "name": "2-acyl LPG is acylated to PG by CRLS1 (IM)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524047", "species_1524038" ], "products": [ "species_29374", "species_1524042" ], "modifiers": [ [ "species_10534747", "catalyst" ] ], "additional_components": [ "WBGene00017763" ] }, "reaction_10565132": { "compartment": "compartment_70101", "id": "reaction_10565132", "reactome": "R-CEL-8851827", "name": "RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10512175", "species_29438" ], "products": [ "species_29420", "species_10511481" ], "modifiers": [ [ "species_10554985", "catalyst" ] ], "additional_components": [ "species_29420", "P22981", "WBGene00002335", "species_29438", "P22981", "WBGene00002335", "Q9XVQ7", "WBGene00008711", "P29355", "WBGene00004774", "Q9N5D3", "WBGene00004947" ] }, "reaction_10565135": { "compartment": "compartment_70101", "id": "reaction_10565135", "reactome": "R-CEL-8851877", "name": "RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10512175", "species_29438" ], "products": [ "species_29420", "species_10511481" ], "modifiers": [ [ "species_10554983", "catalyst" ] ], "additional_components": [ "species_29420", "P22981", "WBGene00002335", "species_29438", "P22981", "WBGene00002335", "Q9XWK4", "WBGene00013202", "Q9XVQ7", "WBGene00008711", "Q9N5D3", "WBGene00004947" ] }, "reaction_10550976": { "compartment": "compartment_7660", "id": "reaction_10550976", "reactome": "R-CEL-5244669", "name": "CDK1 phosphorylates lamins and facilitates depolymerization of lamin filaments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10550899" ], "products": [ "species_113582", "species_10550974" ], "modifiers": [ [ "species_10511241", "catalyst" ] ], "additional_components": [ "Q19782", "WBGene00002058", "P90900", "WBGene00002052", "Q21065", "WBGene00002051", "P90901", "WBGene00002050", "Q21067", "WBGene00002056", "Q09501", "WBGene00002067", "Q21443", "WBGene00003052", "Q19286", "WBGene00002054", "O02365", "WBGene00003485", "Q86DC6", "WBGene00002057", "Q19289", "WBGene00002053", "O45168", "WBGene00002055", "P90900", "WBGene00002052", "Q21443", "WBGene00003052", "P90901", "WBGene00002050", "Q86DC6", "WBGene00002057", "Q09501", "WBGene00002067", "Q19286", "WBGene00002054", "Q19289", "WBGene00002053", "Q19782", "WBGene00002058", "O02365", "WBGene00003485", "Q21065", "WBGene00002051", "O45168", "WBGene00002055", "Q21067", "WBGene00002056", "O45926", "WBGene00000866", "Q10653", "WBGene00000865", "Q9BLB5", "WBGene00000867", "P34556", "WBGene00000405" ] }, "reaction_10550709": { "compartment": "compartment_13231", "id": "reaction_10550709", "reactome": "R-CEL-5221130", "name": "LPIN catalyzes conversion of phosphatidic acid to diacylglycerol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_5221122" ], "products": [ "species_113550", "species_5221124" ], "modifiers": [ [ "species_10549162", "catalyst" ] ], "additional_components": [ "WBGene00010425" ] }, "reaction_10550349": { "compartment": "compartment_7660", "id": "reaction_10550349", "reactome": "R-CEL-5195402", "name": "CDK1 phosphorylates LPIN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10549162" ], "products": [ "species_113582", "species_10549156" ], "modifiers": [ [ "species_10511241", "catalyst" ] ], "additional_components": [ "WBGene00010425", "WBGene00010425", "O45926", "WBGene00000866", "Q10653", "WBGene00000865", "Q9BLB5", "WBGene00000867", "P34556", "WBGene00000405" ] }, "reaction_10549181": { "compartment": "compartment_13231", "id": "reaction_10549181", "reactome": "R-CEL-4419948", "name": "CTDNEP1:CNEP1R1 dephosphorylates LPIN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10549156" ], "products": [ "species_113550", "species_10549162" ], "modifiers": [ [ "species_10549178", "catalyst" ] ], "additional_components": [ "WBGene00010425", "WBGene00010425", "Q20432", "WBGene00018474", "Q9XXN3", "WBGene00011828" ] }, "reaction_10550717": { "compartment": "compartment_13231", "id": "reaction_10550717", "reactome": "R-CEL-5223304", "name": "DAG and Ca+2 bind to PKC and tether it to membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5221124", "species_29496", "species_10550711" ], "products": [ "species_10550715" ], "modifiers": [], "additional_components": [ "WBGene00004033", "P90980", "WBGene00004033", "species_74016", "species_114519" ] }, "reaction_10520494": { "compartment": "compartment_70101", "id": "reaction_10520494", "reactome": "R-CEL-388824", "name": "PTPRF, PTPRS, PTPRD bind Liprins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10520490", "species_10520454" ], "products": [ "species_10520492" ], "modifiers": [], "additional_components": [ "O01736", "WBGene00044348", "Q9BMN8", "WBGene00004215", "O17889", "WBGene00044348", "W6RR46", "WBGene00044348", "Q22852", "WBGene00044348", "Q95Y26", "WBGene00044348", "Q21049", "WBGene00006364", "Q94071", "WBGene00011904", "Q21049", "WBGene00006364", "Q94071", "WBGene00011904", "O01736", "WBGene00044348", "Q9BMN8", "WBGene00004215", "O17889", "WBGene00044348", "W6RR46", "WBGene00044348", "Q22852", "WBGene00044348", "Q95Y26", "WBGene00044348" ] }, "reaction_10559201": { "compartment": "compartment_876", "id": "reaction_10559201", "reactome": "R-CEL-6794346", "name": "NRXNs bind NLGNs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10559197", "species_10559159" ], "products": [ "species_10559199" ], "modifiers": [], "additional_components": [ "Q20826", "WBGene00018878", "Q9XTG1", "WBGene00006412", "I2HAJ6", "WBGene00007799", "O45000", "WBGene00002174", "I2HAJ6", "WBGene00007799", "O45000", "WBGene00002174", "Q20826", "WBGene00018878", "Q9XTG1", "WBGene00006412" ] }, "reaction_10559280": { "compartment": "compartment_876", "id": "reaction_10559280", "reactome": "R-CEL-6797554", "name": "ABP1 binds SHANK proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10515342", "species_10559276" ], "products": [ "species_10559278" ], "modifiers": [], "additional_components": [ "WBGene00010664", "G5ECY0", "WBGene00001006", "Q22638", "WBGene00011890", "I2HAJ6", "WBGene00007799", "O45000", "WBGene00002174", "Q20826", "WBGene00018878", "Q9XTG1", "WBGene00006412", "B7WN72", "WBGene00006444", "G5ECY0", "WBGene00001006", "Q22638", "WBGene00011890", "I2HAJ6", "WBGene00007799", "O45000", "WBGene00002174", "Q20826", "WBGene00018878", "Q9XTG1", "WBGene00006412", "B7WN72", "WBGene00006444", "Q9XUT0", "WBGene00010664" ] }, "reaction_10559284": { "compartment": "compartment_876", "id": "reaction_10559284", "reactome": "R-CEL-6797568", "name": "NRXNs bind CASK:Protein 4.1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10559199", "species_10559241" ], "products": [ "species_10559282" ], "modifiers": [], "additional_components": [ "I2HAJ6", "WBGene00007799", "O45000", "WBGene00002174", "Q20826", "WBGene00018878", "Q9XTG1", "WBGene00006412", "P54936", "WBGene00002991", "H2KZV9", "WBGene00001489", "G5EEG8", "WBGene00001488", "P54936", "WBGene00002991", "H2KZV9", "WBGene00001489", "G5EEG8", "WBGene00001488", "I2HAJ6", "WBGene00007799", "O45000", "WBGene00002174", "Q20826", "WBGene00018878", "Q9XTG1", "WBGene00006412" ] }, "reaction_10559243": { "compartment": "compartment_70101", "id": "reaction_10559243", "reactome": "R-CEL-6797553", "name": "Protein 4.1 binds CASK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10559239", "species_10519878" ], "products": [ "species_10559241" ], "modifiers": [], "additional_components": [ "H2KZV9", "WBGene00001489", "G5EEG8", "WBGene00001488", "WBGene00002991", "P54936", "WBGene00002991", "H2KZV9", "WBGene00001489", "G5EEG8", "WBGene00001488" ] }, "reaction_10564964": { "compartment": "compartment_876", "id": "reaction_10564964", "reactome": "R-CEL-8849878", "name": "PSD-95 binds NMDA receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10564960", "species_10523840" ], "products": [ "species_10564962" ], "modifiers": [], "additional_components": [ "G5EEH3", "WBGene00003775", "G5EGQ9", "WBGene00003774", "species_159549", "species_113552", "G5ECY0", "WBGene00001006", "Q22638", "WBGene00011890", "G5ECY0", "WBGene00001006", "Q22638", "WBGene00011890", "G5EEH3", "WBGene00003775", "G5EGQ9", "WBGene00003774", "species_159549", "species_113552" ] }, "reaction_10552287": { "compartment": "compartment_5460", "id": "reaction_10552287", "reactome": "R-CEL-5419261", "name": "55S ribosome with peptidyl-tRNA in A site binds GFM1:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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"WBGene00015133", "Q9TZ90", "WBGene00018793", "Q21083", "WBGene00010458", "O17005", "WBGene00020717", "Q7KPW7", "WBGene00017997", "Q4W5T0", "WBGene00044344", "Q22623", "WBGene00011883", "Q9NAG2", "WBGene00012992", "Q21939", "WBGene00011247", "O45110", "WBGene00018932", "O44159", "WBGene00016989", "Q95Y83", "WBGene00022470", "Q2L6V2", "WBGene00015092", "P34378", "WBGene00017044", "C0VXV6", "WBGene00021935", "Q9N3F3", "WBGene00021829", "Q95Y71", "WBGene00022493", "Q22140", "WBGene00011412", "P90915", "WBGene00010616", "P49404", "WBGene00016142", "Q95X39", "WBGene00015025", "O76606", "WBGene00020796", "Q9TYJ8", "WBGene00022045", "P91353", "WBGene00019076", "O17839", "WBGene00009128", "Q9GYS9", "WBGene00020348", "Q7YX52", "WBGene00008459", "Q9XX18", "WBGene00012645", "Q22438", "WBGene00011740", "Q6A575", "WBGene00023422", "Q7YWY8", "WBGene00010783", "O18199", "WBGene00013004", "species_29438", "Q95Y73", "WBGene00022491" ] }, "reaction_10552331": { "compartment": "compartment_5460", "id": "reaction_10552331", "reactome": "R-CEL-5419281", "name": "MRRF binds 55S ribosome:mRNA:tRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10552306", "species_10552320" ], "products": [ "species_10552329" ], "modifiers": [], "additional_components": [ "Q93425", "WBGene00008452", "Q9U3Q0", "WBGene00007564", "O61791", "WBGene00020037", "P34748", "WBGene00014224", "Q95Q11", "WBGene00013324", "Q688C0", "WBGene00023487", "P34388", "WBGene00017319", "Q9N361", "WBGene00021920", "Q95QS3", "WBGene00016412", "Q9XWV5", "WBGene00012556", "G5ECC9", "WBGene00010766", "Q22470", "WBGene00011759", "Q22483", "WBGene00020499", "Q9XWP0", "WBGene00012830", "G5EC67", "WBGene00013210", "Q23155", "WBGene00012244", "Q9XTY5", "WBGene00011391", "O61818", "WBGene00044321", "O44133", "WBGene00016057", "Q09261", "WBGene00007859", "G5EFC8", "WBGene00000933", "P49391", "WBGene00011334", "Q9NAP9", "WBGene00010624", "Q19685", "WBGene00009013", "Q9N584", "WBGene00002804", "Q21601", "WBGene00010905", "Q10129", "WBGene00018961", "O17004", "WBGene00020718", "Q11189", "WBGene00015487", "Q9NEI6", "WBGene00012697", "Q09523", "WBGene00008456", "Q9GYI2", "WBGene00017924", "Q21454", "WBGene00010812", "O02207", "WBGene00007215", "Q04907", "WBGene00016249", "Q95QC2", "WBGene00019838", "Q9UA63", "WBGene00021021", "P34384", "WBGene00008514", "Q9BPN6", "WBGene00022373", "O02220", "WBGene00007712", "Q95QL2", "WBGene00008769", "A0A1N7SYX2", "WBGene00003066", "O18180", "WBGene00012361", "P90993", "WBGene00015185", "P34264", "WBGene00015133", "Q9TZ90", "WBGene00018793", "Q21083", "WBGene00010458", "O17005", "WBGene00020717", "Q7KPW7", "WBGene00017997", "Q4W5T0", "WBGene00044344", "Q22623", "WBGene00011883", "Q9NAG2", "WBGene00012992", "Q21939", "WBGene00011247", "O45110", "WBGene00018932", "O44159", "WBGene00016989", "Q95Y83", "WBGene00022470", "Q2L6V2", "WBGene00015092", "P34378", "WBGene00017044", "C0VXV6", "WBGene00021935", "Q9N3F3", "WBGene00021829", "Q95Y71", "WBGene00022493", "Q22140", "WBGene00011412", "P90915", "WBGene00010616", "P49404", "WBGene00016142", "Q95X39", "WBGene00015025", "O76606", "WBGene00020796", "Q9TYJ8", "WBGene00022045", "P91353", "WBGene00019076", "O17839", "WBGene00009128", "Q9GYS9", "WBGene00020348", "Q7YX52", "WBGene00008459", "Q9XX18", "WBGene00012645", "Q22438", "WBGene00011740", "Q6A575", "WBGene00023422", "Q7YWY8", "WBGene00010783", "O18199", "WBGene00013004", "WBGene00020625", "P91478", "WBGene00020625", "Q93425", "WBGene00008452", "Q9U3Q0", "WBGene00007564", "O61791", "WBGene00020037", "P34748", "WBGene00014224", "Q95Q11", "WBGene00013324", "Q688C0", "WBGene00023487", "P34388", "WBGene00017319", "Q9N361", "WBGene00021920", "Q95QS3", "WBGene00016412", "Q9XWV5", "WBGene00012556", "G5ECC9", "WBGene00010766", "Q22470", "WBGene00011759", "Q22483", "WBGene00020499", "Q9XWP0", "WBGene00012830", "G5EC67", "WBGene00013210", "Q23155", "WBGene00012244", "Q9XTY5", "WBGene00011391", "O61818", "WBGene00044321", "O44133", "WBGene00016057", "Q09261", "WBGene00007859", "G5EFC8", "WBGene00000933", "P49391", "WBGene00011334", "Q9NAP9", "WBGene00010624", "Q19685", "WBGene00009013", "Q9N584", "WBGene00002804", "Q21601", "WBGene00010905", "Q10129", "WBGene00018961", "O17004", "WBGene00020718", "Q11189", "WBGene00015487", "Q9NEI6", "WBGene00012697", "Q09523", "WBGene00008456", "Q9GYI2", "WBGene00017924", "Q21454", "WBGene00010812", "O02207", "WBGene00007215", "Q04907", "WBGene00016249", "Q95QC2", "WBGene00019838", "Q9UA63", "WBGene00021021", "P34384", "WBGene00008514", "Q9BPN6", "WBGene00022373", "O02220", "WBGene00007712", "Q95QL2", "WBGene00008769", "A0A1N7SYX2", "WBGene00003066", "O18180", "WBGene00012361", "P90993", "WBGene00015185", "P34264", "WBGene00015133", "Q9TZ90", "WBGene00018793", "Q21083", "WBGene00010458", "O17005", "WBGene00020717", "Q7KPW7", "WBGene00017997", "Q4W5T0", "WBGene00044344", "Q22623", "WBGene00011883", "Q9NAG2", "WBGene00012992", "Q21939", "WBGene00011247", "O45110", "WBGene00018932", "O44159", "WBGene00016989", "Q95Y83", "WBGene00022470", "Q2L6V2", "WBGene00015092", "P34378", "WBGene00017044", "C0VXV6", "WBGene00021935", "Q9N3F3", "WBGene00021829", "Q95Y71", "WBGene00022493", "Q22140", "WBGene00011412", "P90915", "WBGene00010616", "P49404", "WBGene00016142", "Q95X39", "WBGene00015025", "O76606", "WBGene00020796", "Q9TYJ8", "WBGene00022045", "P91353", "WBGene00019076", "O17839", "WBGene00009128", "Q9GYS9", "WBGene00020348", "Q7YX52", "WBGene00008459", "Q9XX18", "WBGene00012645", "Q22438", "WBGene00011740", "Q6A575", "WBGene00023422", "Q7YWY8", "WBGene00010783", "O18199", "WBGene00013004" ] }, "reaction_10552302": { "compartment": "compartment_5460", "id": "reaction_10552302", "reactome": "R-CEL-5419264", "name": "MTRF1L (MTRF1a) or ICT1 binds stop codon in 55S ribosome:mRNA:peptidyl-tRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10552298", "species_113573", "species_10552289" ], "products": [ "species_10552300" ], "modifiers": [], "additional_components": [ "O44568", "WBGene00020993", "Q95QC2", "WBGene00019838", "Q93425", "WBGene00008452", "Q9U3Q0", "WBGene00007564", "O61791", "WBGene00020037", "P34748", "WBGene00014224", "Q95Q11", "WBGene00013324", "Q688C0", "WBGene00023487", "P34388", "WBGene00017319", "Q9N361", "WBGene00021920", "Q95QS3", "WBGene00016412", "Q9XWV5", "WBGene00012556", "G5ECC9", "WBGene00010766", "Q22470", "WBGene00011759", "Q22483", "WBGene00020499", "Q9XWP0", "WBGene00012830", "G5EC67", "WBGene00013210", "Q23155", "WBGene00012244", "Q9XTY5", "WBGene00011391", "O61818", "WBGene00044321", "O44133", "WBGene00016057", "Q09261", "WBGene00007859", "G5EFC8", "WBGene00000933", "P49391", "WBGene00011334", "Q9NAP9", "WBGene00010624", "Q19685", "WBGene00009013", "Q9N584", "WBGene00002804", "Q21601", "WBGene00010905", "Q10129", "WBGene00018961", "O17004", "WBGene00020718", "Q11189", "WBGene00015487", "Q9NEI6", "WBGene00012697", "Q09523", "WBGene00008456", "Q9GYI2", "WBGene00017924", "Q21454", "WBGene00010812", "O02207", "WBGene00007215", "Q04907", "WBGene00016249", "Q95QC2", "WBGene00019838", "Q9UA63", "WBGene00021021", "P34384", "WBGene00008514", "Q9BPN6", "WBGene00022373", "O02220", "WBGene00007712", "Q95QL2", "WBGene00008769", "A0A1N7SYX2", "WBGene00003066", "O18180", "WBGene00012361", "P90993", "WBGene00015185", "P34264", "WBGene00015133", "Q9TZ90", "WBGene00018793", "Q21083", "WBGene00010458", "O17005", "WBGene00020717", "Q7KPW7", "WBGene00017997", "Q4W5T0", "WBGene00044344", "Q22623", "WBGene00011883", "Q9NAG2", "WBGene00012992", "Q21939", "WBGene00011247", "O45110", "WBGene00018932", "O44159", "WBGene00016989", "Q95Y83", "WBGene00022470", "Q2L6V2", "WBGene00015092", "P34378", "WBGene00017044", "C0VXV6", "WBGene00021935", "Q9N3F3", "WBGene00021829", "Q95Y71", "WBGene00022493", "Q22140", "WBGene00011412", "P90915", "WBGene00010616", "P49404", "WBGene00016142", "Q95X39", "WBGene00015025", "O76606", "WBGene00020796", "Q9TYJ8", "WBGene00022045", "P91353", "WBGene00019076", "O17839", "WBGene00009128", "Q9GYS9", "WBGene00020348", "Q7YX52", "WBGene00008459", "Q9XX18", "WBGene00012645", "Q22438", "WBGene00011740", "Q6A575", "WBGene00023422", "Q7YWY8", "WBGene00010783", "O18199", "WBGene00013004", "Q93425", "WBGene00008452", "Q9U3Q0", "WBGene00007564", "O61791", "WBGene00020037", "P34748", "WBGene00014224", "Q95Q11", "WBGene00013324", "Q688C0", "WBGene00023487", "P34388", "WBGene00017319", "Q9N361", "WBGene00021920", "Q95QS3", "WBGene00016412", "Q9XWV5", "WBGene00012556", "G5ECC9", "WBGene00010766", "Q22470", "WBGene00011759", "Q22483", "WBGene00020499", "Q9XWP0", "WBGene00012830", "G5EC67", "WBGene00013210", "Q23155", "WBGene00012244", "Q9XTY5", "WBGene00011391", "O61818", "WBGene00044321", "O44133", "WBGene00016057", "Q09261", "WBGene00007859", "G5EFC8", "WBGene00000933", "P49391", "WBGene00011334", "Q9NAP9", "WBGene00010624", "Q19685", "WBGene00009013", "Q9N584", "WBGene00002804", "Q21601", "WBGene00010905", "Q10129", "WBGene00018961", "O17004", "WBGene00020718", "Q11189", "WBGene00015487", "Q9NEI6", "WBGene00012697", "Q09523", "WBGene00008456", "Q9GYI2", "WBGene00017924", "Q21454", "WBGene00010812", "O02207", "WBGene00007215", "Q04907", "WBGene00016249", "Q95QC2", "WBGene00019838", "Q9UA63", "WBGene00021021", "P34384", "WBGene00008514", "Q9BPN6", "WBGene00022373", "O02220", "WBGene00007712", "Q95QL2", "WBGene00008769", "A0A1N7SYX2", "WBGene00003066", "O18180", "WBGene00012361", "P90993", "WBGene00015185", "P34264", "WBGene00015133", "Q9TZ90", "WBGene00018793", "Q21083", "WBGene00010458", "O17005", "WBGene00020717", "Q7KPW7", "WBGene00017997", "Q4W5T0", "WBGene00044344", "Q22623", "WBGene00011883", "Q9NAG2", "WBGene00012992", "Q21939", "WBGene00011247", "O45110", "WBGene00018932", "O44159", "WBGene00016989", "Q95Y83", "WBGene00022470", "Q2L6V2", "WBGene00015092", "P34378", "WBGene00017044", "C0VXV6", "WBGene00021935", "Q9N3F3", "WBGene00021829", "Q95Y71", "WBGene00022493", "Q22140", "WBGene00011412", "P90915", "WBGene00010616", "P49404", "WBGene00016142", "Q95X39", "WBGene00015025", "O76606", "WBGene00020796", "Q9TYJ8", "WBGene00022045", "P91353", "WBGene00019076", "O17839", "WBGene00009128", "Q9GYS9", "WBGene00020348", "Q7YX52", "WBGene00008459", "Q9XX18", "WBGene00012645", "Q22438", "WBGene00011740", "Q6A575", "WBGene00023422", "Q7YWY8", "WBGene00010783", "O18199", "WBGene00013004", "species_29438", "O44568", "WBGene00020993" ] }, "reaction_10535860": { "compartment": "compartment_984", "id": "reaction_10535860", "reactome": "R-CEL-1602374", "name": "PS is hydrolyzed to 1-acyl LPS by PLA2[15]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_33625" ], "products": [ "species_1602419", "species_1602366" ], "modifiers": [ [ "species_10535837", "catalyst" ], [ "species_10535855", "inhibitor" ] ], "additional_components": [ "species_74016", "Q17790", "WBGene00044468", "O16654", "WBGene00044468", "Q3V5J7", "WBGene00044468", "Q18339", "WBGene00016288", "G4RY15", "WBGene00015631", "P34472", "WBGene00010228", "Q22591", "WBGene00020585" ] }, "reaction_10534870": { "compartment": "compartment_12045", "id": "reaction_10534870", "reactome": "R-CEL-1482776", "name": "PS is hydrolyzed to 1-acyl LPS by PLA2G2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1500646" ], "products": [ "species_1524021", "species_1498724" ], "modifiers": [ [ "species_10534852", "catalyst" ] ], "additional_components": [ "Q3V5J7", "WBGene00044468", "O16654", "WBGene00044468", "Q17790", "WBGene00044468", "species_74016" ] }, "reaction_10534806": { "compartment": "compartment_12045", "id": "reaction_10534806", "reactome": "R-CEL-1482636", "name": "1-acyl LPS is acylated to PS by LPSAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500578", "species_1498724" ], "products": [ "species_76194", "species_1500646" ], "modifiers": [ [ "species_10534803", "catalyst" ] ], "additional_components": [ "G5EC53", "WBGene00016934", "H9G2W5", "WBGene00007446", "O01925", "WBGene00020115" ] }, "reaction_10566472": { "compartment": "compartment_12045", "id": "reaction_10566472", "reactome": "R-CEL-8867876", "name": "OSBPL5,8,10 exchange PS with PI4P from ER membrane to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_392417", "species_1500646" ], "products": [ "species_33625", "species_1806234" ], "modifiers": [ [ "species_10566469", "catalyst" ] ], "additional_components": [ "WBGene00014215" ] }, "reaction_10534861": { "compartment": "compartment_12045", "id": "reaction_10534861", "reactome": "R-CEL-1482691", "name": "2-acyl LPS is acylated to PS by LPSAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500578", "species_1498722" ], "products": [ "species_76194", "species_1500646" ], "modifiers": [ [ "species_10534803", "catalyst" ] ], "additional_components": [ "G5EC53", "WBGene00016934", "H9G2W5", "WBGene00007446", "O01925", "WBGene00020115" ] }, "reaction_10570607": { "compartment": "compartment_5460", "id": "reaction_10570607", "reactome": "R-CEL-8986181", "name": "PITRM1 proteolyzes mitochondrial targeting peptides (presequences)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10570599" ], "products": [], "modifiers": [ [ "species_10570604", "catalyst" ] ], "additional_components": [ "Q9XWJ5", "WBGene00013094", "WBGene00011679" ] }, "reaction_10529207": { "compartment": "compartment_876", "id": "reaction_10529207", "reactome": "R-CEL-917870", "name": "SLC46A1 transports hemes from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9707310" ], "products": [ "species_9707308" ], "modifiers": [ [ "species_10514650", "catalyst" ] ], "additional_components": [ "species_71185", "Q9UAZ6", "WBGene00021159", "Q9XWL3", "WBGene00012811", "H2KZC0", "WBGene00016705", "Q20236", "WBGene00009582" ] }, "reaction_10532366": { "compartment": "compartment_70101", "id": "reaction_10532366", "reactome": "R-CEL-1247960", "name": "Activation of p38 MAPK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10532355" ], "products": [ "species_10532363", "species_29370" ], "modifiers": [ [ "species_10525519", "catalyst" ] ], "additional_components": [ "WBGene00004758" ] }, "reaction_10532487": { "compartment": "compartment_70101", "id": "reaction_10532487", "reactome": "R-CEL-1250264", "name": "TXNIP binds reduced thioredoxin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10532483", "species_10506160" ], "products": [ "species_10532485" ], "modifiers": [], "additional_components": [ "P91469", "WBGene00020612", "Q9XXN6", "WBGene00009000", "O17982", "WBGene00011054", "Q9GYT5", "WBGene00018060", "Q20577", "WBGene00009852", "O17983", "WBGene00011055", "Q9TYQ0", "WBGene00019873", "Q21550", "WBGene00006429", "O44847", "WBGene00020205", "Q9XTU0", "WBGene00013043", "Q22321", "WBGene00020323", "O45782", "WBGene00011732", "Q9XXC4", "WBGene00013086", "D1MN74", "WBGene00009579", "Q23672", "WBGene00014159", "O62274", "WBGene00010268", "Q9XXI0", "WBGene00012467", "O17812", "WBGene00008843", "Q23674", "WBGene00014161", "P30647", "WBGene00014033", "Q9XXI4", "WBGene00012464", "O17981", "WBGene00011052", "Q9GYT4", "WBGene00018061", "WBGene00015062", "Q09433", "WBGene00015062", "P91469", "WBGene00020612", "Q9XXN6", "WBGene00009000", "O17982", "WBGene00011054", "Q9GYT5", "WBGene00018060", "Q20577", "WBGene00009852", "O17983", "WBGene00011055", "Q9TYQ0", "WBGene00019873", "Q21550", "WBGene00006429", "O44847", "WBGene00020205", "Q9XTU0", "WBGene00013043", "Q22321", "WBGene00020323", "O45782", "WBGene00011732", "Q9XXC4", "WBGene00013086", "D1MN74", "WBGene00009579", "Q23672", "WBGene00014159", "O62274", "WBGene00010268", "Q9XXI0", "WBGene00012467", "O17812", "WBGene00008843", "Q23674", "WBGene00014161", "P30647", "WBGene00014033", "Q9XXI4", "WBGene00012464", "O17981", "WBGene00011052", "Q9GYT4", "WBGene00018061" ] }, "reaction_10532489": { "compartment": "compartment_70101", "id": "reaction_10532489", "reactome": "R-CEL-1250280", "name": "ROS oxidize thioredoxin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10506160", "species_1250243" ], "products": [ "species_10506158" ], "modifiers": [], "additional_components": [ "WBGene00015062", "WBGene00015062" ] }, "reaction_10571508": { "compartment": "compartment_7660", "id": "reaction_10571508", "reactome": "R-CEL-9021357", "name": "PRKCI phosphorylates ELF3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10571503" ], "products": [ "species_113582", "species_10571503" ], "modifiers": [ [ "species_10571505", "catalyst" ] ], "additional_components": [ "WBGene00006462", "WBGene00006462", "WBGene00004034" ] }, "reaction_10538172": { "compartment": "compartment_70101", "id": "reaction_10538172", "reactome": "R-CEL-1912382", "name": "Mature NOTCH heterodimer traffics to the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10538156" ], "products": [ "species_10538165" ], "modifiers": [ [ "species_10538170", "inhibitor" ] ], "additional_components": [ "Q21850", "WBGene00019957", "Q21850", "WBGene00019957", "WBGene00004766" ] }, "reaction_10532496": { "compartment": "compartment_876", "id": "reaction_10532496", "reactome": "R-CEL-1250370", "name": "Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10532493", "catalyst" ] ], "additional_components": [ "G5EDP9", "WBGene00000001", "Q94125", "WBGene00000090" ] }, "reaction_10532624": { "compartment": "compartment_70101", "id": "reaction_10532624", "reactome": "R-CEL-1253343", "name": "WWOX binds ERBB4s80", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10532620", "species_10532532" ], "products": [ "species_10532622" ], "modifiers": [], "additional_components": [ "WBGene00000971", "P24348", "WBGene00002299", "P24348", "WBGene00002299", "Q19062", "WBGene00000971" ] }, "reaction_10532677": { "compartment": "compartment_70101", "id": "reaction_10532677", "reactome": "R-CEL-1254376", "name": "Translocation of cytosolic ERBB4s80 to mitochondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10532532" ], "products": [ "species_10532675" ], "modifiers": [], "additional_components": [ "P24348", "WBGene00002299", "P24348", "WBGene00002299" ] }, "reaction_10532663": { "compartment": "compartment_70101", "id": "reaction_10532663", "reactome": "R-CEL-1254285", "name": "ERBB4s80:STAT5A complex translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10532651" ], "products": [ "species_10532661" ], "modifiers": [], "additional_components": [ "P24348", "WBGene00002299", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "P24348", "WBGene00002299" ] }, "reaction_10532665": { "compartment": "compartment_70101", "id": "reaction_10532665", "reactome": "R-CEL-1254291", "name": "ERBB4s80 binds STAT5A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10532649", "species_10532532" ], "products": [ "species_10532651" ], "modifiers": [], "additional_components": [ "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "P24348", "WBGene00002299", "P24348", "WBGene00002299", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111" ] }, "reaction_10532603": { "compartment": "compartment_70101", "id": "reaction_10532603", "reactome": "R-CEL-1252013", "name": "Translocation of ERBB4s80 to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10532532" ], "products": [ "species_10532599" ], "modifiers": [ [ "species_10532601", "inhibitor" ] ], "additional_components": [ "P24348", "WBGene00002299", "P24348", "WBGene00002299", "P24348", "WBGene00002299", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635" ] }, "reaction_10532589": { "compartment": "compartment_70101", "id": "reaction_10532589", "reactome": "R-CEL-1251997", "name": "Cleavage of ERBB4m80 by gamma-scretase complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10532522" ], "products": [ "species_10532532" ], "modifiers": [ [ "species_10532586", "catalyst" ] ], "additional_components": [ "P24348", "WBGene00002299", "P24348", "WBGene00002299", "Q23316", "WBGene00000148", "P52166", "WBGene00004769", "Q01608", "WBGene00004958", "O02100", "WBGene00001985", "Q9U357", "WBGene00003975", "O45876", "WBGene00000147" ] }, "reaction_10532637": { "compartment": "compartment_70101", "id": "reaction_10532637", "reactome": "R-CEL-1254248", "name": "Translocation of ERBB4s80:YAP1 complex to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10532631" ], "products": [ "species_10532635" ], "modifiers": [], "additional_components": [ "P24348", "WBGene00002299", "Q19404", "WBGene00008748", "P24348", "WBGene00002299", "Q19404", "WBGene00008748" ] }, "reaction_10532639": { "compartment": "compartment_70101", "id": "reaction_10532639", "reactome": "R-CEL-1254251", "name": "ERBB4s80 binds YAP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10532629", "species_10532532" ], "products": [ "species_10532631" ], "modifiers": [], "additional_components": [ "WBGene00008748", "P24348", "WBGene00002299", "P24348", "WBGene00002299", "Q19404", "WBGene00008748" ] }, "reaction_10538338": { "compartment": "compartment_70101", "id": "reaction_10538338", "reactome": "R-CEL-1977296", "name": "NEDD4 ubiquitinates ERBB4jmAcyt1s80 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10538331", "species_10502375" ], "products": [ "species_10538335" ], "modifiers": [ [ "species_10538331", "catalyst" ] ], "additional_components": [ "A0A061ACQ8", "WBGene00022358", "P24348", "WBGene00002299", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "A0A061ACQ8", "WBGene00022358", "P24348", "WBGene00002299", "A0A061ACQ8", "WBGene00022358", "P24348", "WBGene00002299" ] }, "reaction_10532613": { "compartment": "compartment_70101", "id": "reaction_10532613", "reactome": "R-CEL-1253282", "name": "ERBB4 ubiquitination by WWP1/ITCH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502375", "species_10532608" ], "products": [ "species_10532610" ], "modifiers": [ [ "species_10532608", "catalyst" ] ], "additional_components": [ "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "Q9N2Z7", "WBGene00007009", "P24348", "WBGene00002299", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "Q9N2Z7", "WBGene00007009", "P24348", "WBGene00002299", "Q9N2Z7", "WBGene00007009", "P24348", "WBGene00002299" ] }, "reaction_10532615": { "compartment": "compartment_876", "id": "reaction_10532615", "reactome": "R-CEL-1253300", "name": "ERBB4 binds WWP1/ITCH ubiquitin ligases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10532606", "species_10530908" ], "products": [ "species_10532608" ], "modifiers": [], "additional_components": [ "P24348", "WBGene00002299", "WBGene00007009", "Q9N2Z7", "WBGene00007009", "P24348", "WBGene00002299" ] }, "reaction_10572102": { "compartment": "compartment_876", "id": "reaction_10572102", "reactome": "R-CEL-9612219", "name": "ERBB4s80 binds to SRC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10518187", "species_10532532" ], "products": [ "species_10532601" ], "modifiers": [], "additional_components": [ "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "P24348", "WBGene00002299", "P24348", "WBGene00002299", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635" ] }, "reaction_10538333": { "compartment": "compartment_70101", "id": "reaction_10538333", "reactome": "R-CEL-1973956", "name": "NEDD4 binds ERBB4jmAcyt1s80 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10532526", "species_10530876" ], "products": [ "species_10538331" ], "modifiers": [], "additional_components": [ "P24348", "WBGene00002299", "WBGene00022358", "A0A061ACQ8", "WBGene00022358", "P24348", "WBGene00002299" ] }, "reaction_10509830": { "compartment": "compartment_70101", "id": "reaction_10509830", "reactome": "R-CEL-141429", "name": "Inactivation of APC/C via CDC20 sequestration", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509819", "species_10509824" ], "products": [ "species_10509828" ], "modifiers": [], "additional_components": [ "WBGene00001511", "WBGene00003161", "Q9NGT3", "WBGene00003161", "Q09373", "WBGene00001511" ] }, "reaction_10509832": { "compartment": "compartment_70101", "id": "reaction_10509832", "reactome": "R-CEL-141437", "name": "Formation of the MCC complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509819", "species_10509814", "species_10509809", "species_10509824" ], "products": [ "species_10509826" ], "modifiers": [], "additional_components": [ "WBGene00001511", "WBGene00013209", "WBGene00000275", "WBGene00003161", "Q9NGT3", "WBGene00003161", "Q21776", "WBGene00000275", "Q9XWH0", "WBGene00013209", "Q09373", "WBGene00001511" ] }, "reaction_10511637": { "compartment": "compartment_7660", "id": "reaction_10511637", "reactome": "R-CEL-174251", "name": "Phosphorylation of Cdh1 by Cyclin B1:Cdc2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10511632" ], "products": [ "species_113582", "species_10511634" ], "modifiers": [ [ "species_10511241", "catalyst" ] ], "additional_components": [ "WBGene00001510", "WBGene00001510", "O45926", "WBGene00000866", "Q10653", "WBGene00000865", "Q9BLB5", "WBGene00000867", "P34556", "WBGene00000405" ] }, "reaction_10522739": { "compartment": "compartment_70101", "id": "reaction_10522739", "reactome": "R-CEL-426240", "name": "DAG kinase produces phosphatidic acid from DAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_114519" ], "products": [ "species_76108", "species_29370" ], "modifiers": [ [ "species_10522736", "catalyst" ] ], "additional_components": [ "Q03603", "WBGene00000960", "Q10024", "WBGene00019428", "H2KZC9", "WBGene00006483", "H2KYI9", "WBGene00000959", "Q17860", "WBGene00000958" ] }, "reaction_10509684": { "compartment": "compartment_114521", "id": "reaction_10509684", "reactome": "R-CEL-139854", "name": "IP3R tetramer:I(1,4,5)P3:4xCa2+ transports Ca2+ from platelet dense tubular system to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_139827" ], "products": [ "species_74016" ], "modifiers": [ [ "species_10509681", "catalyst" ] ], "additional_components": [ "species_114520", "species_74016", "Q9Y0A1", "WBGene00002173" ] }, "reaction_10522615": { "compartment": "compartment_876", "id": "reaction_10522615", "reactome": "R-CEL-426032", "name": "DAG is metabolized by DAGL to 2-AG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_114519" ], "products": [ "species_426026", "species_426030" ], "modifiers": [ [ "species_10522612", "catalyst" ] ], "additional_components": [ "WBGene00018364" ] }, "reaction_10557468": { "compartment": "compartment_876", "id": "reaction_10557468", "reactome": "R-CEL-5694462", "name": "ABHD6,12 hydrolyse 3AG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_5694509" ], "products": [ "species_422506", "species_70106", "species_76116" ], "modifiers": [ [ "species_10557465", "catalyst" ] ], "additional_components": [ "WBGene00022393" ] }, "reaction_10509686": { "compartment": "compartment_70101", "id": "reaction_10509686", "reactome": "R-CEL-139941", "name": "Binding of IP3 to IP3 receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509679", "species_114520" ], "products": [ "species_10509681" ], "modifiers": [], "additional_components": [ "Q9Y0A1", "WBGene00002173", "species_114520", "species_74016", "Q9Y0A1", "WBGene00002173" ] }, "reaction_10522696": { "compartment": "compartment_876", "id": "reaction_10522696", "reactome": "R-CEL-426209", "name": "DAG activation of TRPC channels", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_114519", "species_10522688" ], "products": [ "species_10522694" ], "modifiers": [], "additional_components": [ "WBGene00006615", "Q8I6Y9", "WBGene00006615", "species_114519" ] }, "reaction_10522510": { "compartment": "compartment_70101", "id": "reaction_10522510", "reactome": "R-CEL-425861", "name": "Activation of Protein Kinase C novel isoforms", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_114519", "species_10513858" ], "products": [ "species_10522508" ], "modifiers": [], "additional_components": [ "P34885", "WBGene00004032", "P34722", "WBGene00006599", "P34885", "WBGene00004032", "P34722", "WBGene00006599", "species_114519" ] }, "reaction_10506679": { "compartment": "compartment_70101", "id": "reaction_10506679", "reactome": "R-CEL-74372", "name": "uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_83962", "species_500244" ], "products": [ "species_29372", "species_500430" ], "modifiers": [ [ "species_10506676", "catalyst" ] ], "additional_components": [ "CHEBI:28542", "species_112016", "CHEBI:16450", "CHEBI:16704", "Q23588", "WBGene00022817" ] }, "reaction_10508615": { "compartment": "compartment_70101", "id": "reaction_10508615", "reactome": "R-CEL-109903", "name": "cytidine or uridine + ATP => CMP or UMP + ADP [UCK2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_500759" ], "products": [ "species_500761", "species_29370" ], "modifiers": [ [ "species_10508612", "catalyst" ] ], "additional_components": [ "CHEBI:16704", "CHEBI:17562", "species_109395", "species_109402", "Q17413", "WBGene00007089" ] }, "reaction_10558281": { "compartment": "compartment_70101", "id": "reaction_10558281", "reactome": "R-CEL-6788295", "name": "HDHD1:Mg2+ dephosphorylates PURIDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_6788291" ], "products": [ "species_29372", "species_6788290" ], "modifiers": [ [ "species_10558278", "catalyst" ] ], "additional_components": [ "G5EG26", "WBGene00020113", "species_114632" ] }, "reaction_10506106": { "compartment": "compartment_70101", "id": "reaction_10506106", "reactome": "R-CEL-73599", "name": "cytidine or uridine + ATP => CMP or UMP + ADP [UCK1]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_500759" ], "products": [ "species_500761", "species_29370" ], "modifiers": [ [ "species_10506103", "catalyst" ] ], "additional_components": [ "CHEBI:16704", "CHEBI:17562", "species_109395", "species_109402", "Q17413", "WBGene00007089" ] }, "reaction_10569948": { "compartment": "compartment_70101", "id": "reaction_10569948", "reactome": "R-CEL-8954327", "name": "UCKL1 phosphorylates urindine, cytidine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_500759" ], "products": [ "species_500761", "species_29370" ], "modifiers": [ [ "species_10569945", "catalyst" ] ], "additional_components": [ "CHEBI:16704", "CHEBI:17562", "species_109395", "species_109402", "WBGene00008948" ] }, "reaction_10506142": { "compartment": "compartment_70101", "id": "reaction_10506142", "reactome": "R-CEL-73632", "name": "thymidine + ATP => TMP (deoxythymidine 5'-monophosphate) + ADP [TK1]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_83928" ], "products": [ "species_29370", "species_109366" ], "modifiers": [ [ "species_10506139", "catalyst" ] ], "additional_components": [ "G5EEZ5", "WBGene00006568" ] }, "reaction_10506126": { "compartment": "compartment_70101", "id": "reaction_10506126", "reactome": "R-CEL-73608", "name": "(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_500829" ], "products": [ "species_500430", "species_31633" ], "modifiers": [ [ "species_10506123", "catalyst" ] ], "additional_components": [ "CHEBI:15698", "CHEBI:17562", "CHEBI:16450", "CHEBI:16704", "species_216785", "Q20628", "WBGene00000392" ] }, "reaction_10509057": { "compartment": "compartment_70101", "id": "reaction_10509057", "reactome": "R-CEL-111966", "name": "GRK2 binds CALM1:4Ca2+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509037", "species_10508995" ], "products": [ "species_10509039" ], "modifiers": [ [ "species_10509055", "inhibitor" ] ], "additional_components": [ "WBGene00001709", "species_74016", "Q11083", "WBGene00020378", "P04630", "WBGene00000285", "G5EF37", "WBGene00003934", "A0A2C9C3L3", "WBGene00020378", "Q18136", "WBGene00006861", "Q09665", "WBGene00006583", "O02159", "WBGene00020378", "G5EDZ8", "WBGene00000288", "Q94288", "WBGene00000287", "Q09980", "WBGene00017394", "O16305", "WBGene00000552", "G5EEG0", "WBGene00000286", "species_74016", "Q11083", "WBGene00020378", "P04630", "WBGene00000285", "G5EF37", "WBGene00003934", "A0A2C9C3L3", "WBGene00020378", "Q18136", "WBGene00006861", "Q09665", "WBGene00006583", "O02159", "WBGene00020378", "G5EDZ8", "WBGene00000288", "Q94288", "WBGene00000287", "Q09980", "WBGene00017394", "O16305", "WBGene00000552", "G5EEG0", "WBGene00000286", "Q09639", "WBGene00001709", "species_74016", "P90980", "WBGene00004033", "P34722", "WBGene00006599" ] }, "reaction_10508962": { "compartment": "compartment_70101", "id": "reaction_10508962", "reactome": "R-CEL-111925", "name": "cAMP induces dissociation of inactive PKA tetramers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508958" ], "products": [ "species_10508954", "species_10508960" ], "modifiers": [], "additional_components": [ "species_30389", "P30625", "WBGene00002190", "P21137", "WBGene00002189", "WBGene00002189", "P30625", "WBGene00002190", "species_30389" ] }, "reaction_10508997": { "compartment": "compartment_876", "id": "reaction_10508997", "reactome": "R-CEL-111930", "name": "Adenylate cyclase produces cAMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592" ], "products": [ "species_111294", "species_30389" ], "modifiers": [ [ "species_10508992", "catalyst" ], [ "species_10508995", "catalyst" ] ], "additional_components": [ "species_114632", "Q19523", "WBGene00000068", "O16880", "WBGene00000069", "G5EE33", "WBGene00000070", "Q966F9", "WBGene00000071", "species_74016", "Q11083", "WBGene00020378", "P04630", "WBGene00000285", "G5EF37", "WBGene00003934", "A0A2C9C3L3", "WBGene00020378", "Q18136", "WBGene00006861", "Q09665", "WBGene00006583", "O02159", "WBGene00020378", "G5EDZ8", "WBGene00000288", "Q94288", "WBGene00000287", "Q09980", "WBGene00017394", "O16305", "WBGene00000552", "G5EEG0", "WBGene00000286" ] }, "reaction_10569054": { "compartment": "compartment_70101", "id": "reaction_10569054", "reactome": "R-CEL-8951727", "name": "cAMP binds PKA tetramer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508956", "species_30389" ], "products": [ "species_10508958" ], "modifiers": [], "additional_components": [ "P30625", "WBGene00002190", "P21137", "WBGene00002189", "species_30389", "P30625", "WBGene00002190", "P21137", "WBGene00002189" ] }, "reaction_10509064": { "compartment": "compartment_876", "id": "reaction_10509064", "reactome": "R-CEL-111970", "name": "PKC phosphorylates GRK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509037", "species_113592" ], "products": [ "species_29370", "species_10509061" ], "modifiers": [ [ "species_10509055", "catalyst" ] ], "additional_components": [ "WBGene00001709", "WBGene00001709", "species_74016", "P90980", "WBGene00004033", "P34722", "WBGene00006599" ] }, "reaction_10524537": { "compartment": "compartment_70101", "id": "reaction_10524537", "reactome": "R-CEL-442749", "name": "CaMKK autophosphorylates in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10524529" ], "products": [ "species_113582", "species_10524534" ], "modifiers": [ [ "species_10524529", "catalyst" ] ], "additional_components": [ "species_74016", "A0A2C9C3L3", "WBGene00020378", "Q09980", "WBGene00017394", "G5EDZ8", "WBGene00000288", "Q11083", "WBGene00020378", "G5EEG0", "WBGene00000286", "Q18136", "WBGene00006861", "G5EF37", "WBGene00003934", "Q94288", "WBGene00000287", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "P04630", "WBGene00000285", "Q09665", "WBGene00006583", "Q3Y416", "WBGene00000518", "Q3Y416", "WBGene00000518", "species_74016", "A0A2C9C3L3", "WBGene00020378", "Q09980", "WBGene00017394", "G5EDZ8", "WBGene00000288", "Q11083", "WBGene00020378", "G5EEG0", "WBGene00000286", "Q18136", "WBGene00006861", "G5EF37", "WBGene00003934", "Q94288", "WBGene00000287", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "P04630", "WBGene00000285", "Q09665", "WBGene00006583", "species_74016", "A0A2C9C3L3", "WBGene00020378", "Q09980", "WBGene00017394", "G5EDZ8", "WBGene00000288", "Q11083", "WBGene00020378", "G5EEG0", "WBGene00000286", "Q18136", "WBGene00006861", "G5EF37", "WBGene00003934", "Q94288", "WBGene00000287", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "P04630", "WBGene00000285", "Q09665", "WBGene00006583", "Q3Y416", "WBGene00000518" ] }, "reaction_10509018": { "compartment": "compartment_70101", "id": "reaction_10509018", "reactome": "R-CEL-111955", "name": "cAMP hydrolysis by Cam-PDE 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_30389" ], "products": [ "species_76577" ], "modifiers": [ [ "species_10509015", "catalyst" ] ], "additional_components": [ "O18696", "WBGene00011433" ] }, "reaction_10509020": { "compartment": "compartment_70101", "id": "reaction_10509020", "reactome": "R-CEL-111956", "name": "Calmodulin activates Cam-PDE 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509015" ], "products": [ "species_10509015" ], "modifiers": [ [ "species_10508995", "catalyst" ] ], "additional_components": [ "O18696", "WBGene00011433", "O18696", "WBGene00011433", "species_74016", "Q11083", "WBGene00020378", "P04630", "WBGene00000285", "G5EF37", "WBGene00003934", "A0A2C9C3L3", "WBGene00020378", "Q18136", "WBGene00006861", "Q09665", "WBGene00006583", "O02159", "WBGene00020378", "G5EDZ8", "WBGene00000288", "Q94288", "WBGene00000287", "Q09980", "WBGene00017394", "O16305", "WBGene00000552", "G5EEG0", "WBGene00000286" ] }, "reaction_10562897": { "compartment": "compartment_876", "id": "reaction_10562897", "reactome": "R-CEL-6801101", "name": "RABGGTA binds RABGGTB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10562893", "species_10562888" ], "products": [ "species_10562895" ], "modifiers": [], "additional_components": [ "WBGene00015099", "WBGene00019778", "Q9TYY0", "WBGene00019778", "P41992", "WBGene00015099" ] }, "reaction_10562906": { "compartment": "compartment_70101", "id": "reaction_10562906", "reactome": "R-CEL-6801109", "name": "CHM binds RGGT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10562895", "species_10562902" ], "products": [ "species_10562904" ], "modifiers": [], "additional_components": [ "Q9TYY0", "WBGene00019778", "P41992", "WBGene00015099", "WBGene00022051", "Q9BKQ5", "WBGene00022051", "Q9TYY0", "WBGene00019778", "P41992", "WBGene00015099" ] }, "reaction_10562850": { "compartment": "compartment_70101", "id": "reaction_10562850", "reactome": "R-CEL-6800793", "name": "PIDD1 translocates to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10562842" ], "products": [ "species_10562848" ], "modifiers": [], "additional_components": [ "Q09564", "WBGene00009647", "Q17989", "WBGene00015779", "Q09564", "WBGene00009647", "Q17989", "WBGene00015779" ] }, "reaction_10563082": { "compartment": "compartment_7660", "id": "reaction_10563082", "reactome": "R-CEL-6805061", "name": "CK2 binds FACT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10563078", "species_10509283" ], "products": [ "species_10563080" ], "modifiers": [], "additional_components": [ "P18334", "WBGene00002191", "P28548", "WBGene00002196", "Q9N5R9", "WBGene00018849", "P41848", "WBGene00001974", "Q9N5R9", "WBGene00018849", "P41848", "WBGene00001974", "P18334", "WBGene00002191", "P28548", "WBGene00002196" ] }, "reaction_10567715": { "compartment": "compartment_7660", "id": "reaction_10567715", "reactome": "R-CEL-8877692", "name": "PIN1 binds phosphorylated PIP4K2B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10567708", "species_10529334" ], "products": [ "species_10567713" ], "modifiers": [], "additional_components": [ "Q9BL73", "WBGene00004088", "WBGene00022448", "Q9N492", "WBGene00022448", "Q9BL73", "WBGene00004088" ] }, "reaction_10567711": { "compartment": "compartment_7660", "id": "reaction_10567711", "reactome": "R-CEL-8877691", "name": "MAP2K6 phosphorylates PIP4K2B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10567697" ], "products": [ "species_113582", "species_10567708" ], "modifiers": [ [ "species_10525531", "catalyst" ] ], "additional_components": [ "Q9BL73", "WBGene00004088", "Q9BL73", "WBGene00004088", "WBGene00004758" ] }, "reaction_10559206": { "compartment": "compartment_70101", "id": "reaction_10559206", "reactome": "R-CEL-6795290", "name": "TORC2 complex phosphorylates SGK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10545420", "species_113592" ], "products": [ "species_29370", "species_10559204" ], "modifiers": [ [ "species_10513953", "catalyst" ] ], "additional_components": [ "WBGene00004789", "WBGene00004789", "P91040", "WBGene00015697", "Q95Q95", "WBGene00002583", "G5EFN2", "WBGene00009245", "Q9NA80", "WBGene00013261" ] }, "reaction_10559211": { "compartment": "compartment_70101", "id": "reaction_10559211", "reactome": "R-CEL-6795473", "name": "PDPK1 phosphorylates SGK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10559204" ], "products": [ "species_29370", "species_10559209" ], "modifiers": [ [ "species_10508530", "catalyst" ] ], "additional_components": [ "WBGene00004789", "WBGene00004789", "Q9UA62", "WBGene00021022", "species_179838" ] }, "reaction_10559312": { "compartment": "compartment_7660", "id": "reaction_10559312", "reactome": "R-CEL-6797616", "name": "CCNK:CDK12 binds RNA Pol II at DNA repair genes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10559292", "species_10559218" ], "products": [ "species_10559294" ], "modifiers": [], "additional_components": [ "Q9N5R9", "WBGene00018849", "P41848", "WBGene00001974", "Q9N554", "WBGene00021281", "H2KYV0", "WBGene00016115", "P52652", "WBGene00012000", "Q09413", "WBGene00010990", "Q9BKS1", "WBGene00001236", "G5ECR7", "WBGene00001235", "Q9TVL3", "WBGene00000410", "P34424", "WBGene00000508", "P34425", "WBGene00000507", "O17869", "WBGene00009650", "Q9TZ93", "WBGene00005014", "Q21338", "WBGene00005015", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q9XUM4", "WBGene00012236", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "P46551", "WBGene00007135", "O17869", "WBGene00009650", "P46551", "WBGene00007135", "O17869", "WBGene00009650", "Q9N5R9", "WBGene00018849", "P41848", "WBGene00001974", "Q9N554", "WBGene00021281", "H2KYV0", "WBGene00016115", "P52652", "WBGene00012000", "Q09413", "WBGene00010990", "Q9BKS1", "WBGene00001236", "G5ECR7", "WBGene00001235", "Q9TVL3", "WBGene00000410", "P34424", "WBGene00000508", "P34425", "WBGene00000507", "Q9TZ93", "WBGene00005014", "Q21338", "WBGene00005015", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q9XUM4", "WBGene00012236", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529" ] }, "reaction_10559220": { "compartment": "compartment_7660", "id": "reaction_10559220", "reactome": "R-CEL-6797090", "name": "CCNK binds CDK12", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509199", "species_10559216" ], "products": [ "species_10559218" ], "modifiers": [], "additional_components": [ "WBGene00009650", "WBGene00007135", "P46551", "WBGene00007135", "O17869", "WBGene00009650" ] }, "reaction_10559226": { "compartment": "compartment_7660", "id": "reaction_10559226", "reactome": "R-CEL-6797100", "name": "CCNK binds CDK13", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509199", "species_10559222" ], "products": [ "species_10559224" ], "modifiers": [], "additional_components": [ "WBGene00009650", "WBGene00007135", "P46551", "WBGene00007135", "O17869", "WBGene00009650" ] }, "reaction_10559310": { "compartment": "compartment_7660", "id": "reaction_10559310", "reactome": "R-CEL-6797606", "name": "CDK12 phosphorylates RNA Pol II CTD at DNA repair genes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10559294", "species_29358" ], "products": [ "species_113582", "species_10559307" ], "modifiers": [ [ "species_10559294", "catalyst" ] ], "additional_components": [ "P46551", "WBGene00007135", "O17869", "WBGene00009650", "Q9N5R9", "WBGene00018849", "P41848", "WBGene00001974", "Q9N554", "WBGene00021281", "H2KYV0", "WBGene00016115", "P52652", "WBGene00012000", "Q09413", "WBGene00010990", "Q9BKS1", "WBGene00001236", "G5ECR7", "WBGene00001235", "Q9TVL3", "WBGene00000410", "P34424", "WBGene00000508", "P34425", "WBGene00000507", "Q9TZ93", "WBGene00005014", "Q21338", "WBGene00005015", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q9XUM4", "WBGene00012236", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "P46551", "WBGene00007135", "O17869", "WBGene00009650", "Q9N5R9", "WBGene00018849", "P41848", "WBGene00001974", "Q9TVL3", "WBGene00000410", "P34424", "WBGene00000508", "P34425", "WBGene00000507", "Q9TZ93", "WBGene00005014", "Q21338", "WBGene00005015", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q9XUM4", "WBGene00012236", "Q9N554", "WBGene00021281", "H2KYV0", "WBGene00016115", "P52652", "WBGene00012000", "Q09413", "WBGene00010990", "Q9BKS1", "WBGene00001236", "G5ECR7", "WBGene00001235", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "P46551", "WBGene00007135", "O17869", "WBGene00009650", "Q9N5R9", "WBGene00018849", "P41848", "WBGene00001974", "Q9N554", "WBGene00021281", "H2KYV0", "WBGene00016115", "P52652", "WBGene00012000", "Q09413", "WBGene00010990", "Q9BKS1", "WBGene00001236", "G5ECR7", "WBGene00001235", "Q9TVL3", "WBGene00000410", "P34424", "WBGene00000508", "P34425", "WBGene00000507", "Q9TZ93", "WBGene00005014", "Q21338", "WBGene00005015", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q9XUM4", "WBGene00012236", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529" ] }, "reaction_10547457": { "compartment": "compartment_70101", "id": "reaction_10547457", "reactome": "R-CEL-3341343", "name": "PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10506160", "species_29408" ], "products": [ "species_10506158", "species_29356" ], "modifiers": [ [ "species_10547454", "catalyst" ] ], "additional_components": [ "WBGene00015062", "WBGene00015062", "A0A0K3AUJ9", "F09E5.15c" ] }, "reaction_10503060": { "compartment": "compartment_70101", "id": "reaction_10503060", "reactome": "R-CEL-70475", "name": "D-fructose 6-phosphate <=> alpha-D-Glucose 6-phosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29512" ], "products": [ "species_30537" ], "modifiers": [ [ "species_10503055", "catalyst" ] ], "additional_components": [ "Q7K707", "WBGene00013597" ] }, "reaction_10504231": { "compartment": "compartment_70101", "id": "reaction_10504231", "reactome": "R-CEL-71682", "name": "glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_111745" ], "products": [ "species_29450", "species_29366" ], "modifiers": [ [ "species_10504228", "catalyst" ] ], "additional_components": [ "Q93379", "WBGene00008117", "species_113596" ] }, "reaction_10502920": { "compartment": "compartment_70101", "id": "reaction_10502920", "reactome": "R-CEL-70377", "name": "alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30537", "species_29366" ], "products": [ "species_70106", "species_31467", "species_29364" ], "modifiers": [ [ "species_10502917", "catalyst" ] ], "additional_components": [ "species_29366", "Q27464", "WBGene00007108" ] }, "reaction_10506170": { "compartment": "compartment_70101", "id": "reaction_10506170", "reactome": "R-CEL-73646", "name": "thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10506158", "species_70106", "species_29364" ], "products": [ "species_29366", "species_10506160" ], "modifiers": [ [ "species_10506167", "catalyst" ] ], "additional_components": [ "WBGene00015062", "WBGene00015062", "Q17745", "WBGene00015553", "species_113596" ] }, "reaction_10553994": { "compartment": "compartment_70101", "id": "reaction_10553994", "reactome": "R-CEL-5631903", "name": "SESN1,2,3 bind overoxidized PRDX1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10553978", "species_10553986" ], "products": [ "species_10553992" ], "modifiers": [], "additional_components": [ "A0A0K3AUJ9", "F09E5.15c", "WBGene00022279", "Q9N4D6", "WBGene00022279", "A0A0K3AUJ9", "F09E5.15c" ] }, "reaction_10553981": { "compartment": "compartment_70101", "id": "reaction_10553981", "reactome": "R-CEL-5631885", "name": "PRDX1 overoxidizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10547448", "species_29408" ], "products": [ "species_29356", "species_10553978" ], "modifiers": [ [ "species_10547448", "catalyst" ] ], "additional_components": [ "A0A0K3AUJ9", "F09E5.15c", "A0A0K3AUJ9", "F09E5.15c", "A0A0K3AUJ9", "F09E5.15c" ] }, "reaction_10519966": { "compartment": "compartment_70101", "id": "reaction_10519966", "reactome": "R-CEL-380979", "name": "RHEB in mTORC1:RHEB:GTP hydrolyses GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10510588" ], "products": [ "species_29372", "species_10519963" ], "modifiers": [ [ "species_10510588", "catalyst" ] ], "additional_components": [ "Q19425", "WBGene00008774", "species_29420", "G5EGB3", "WBGene00012497", "Q22743", "WBGene00006414", "species_29438", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "P91040", "WBGene00015697", "Q95Q95", "WBGene00002583", "Q68TI8", "WBGene00000911", "P34443", "WBGene00010038", "P34443", "WBGene00010038", "species_29420", "Q19425", "WBGene00008774", "G5EGB3", "WBGene00012497", "Q22743", "WBGene00006414", "species_29438", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "P91040", "WBGene00015697", "Q95Q95", "WBGene00002583", "Q68TI8", "WBGene00000911", "Q19425", "WBGene00008774", "species_29420", "G5EGB3", "WBGene00012497", "Q22743", "WBGene00006414", "species_29438", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "P91040", "WBGene00015697", "Q95Q95", "WBGene00002583", "Q68TI8", "WBGene00000911", "P34443", "WBGene00010038" ] }, "reaction_10553998": { "compartment": "compartment_70101", "id": "reaction_10553998", "reactome": "R-CEL-5631941", "name": "SESN1,2,3 bind AMPK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10553986", "species_10519954" ], "products": [ "species_10553996" ], "modifiers": [], "additional_components": [ "WBGene00022279", "species_76577", "Q9XUY2", "WBGene00010115", "P45894", "WBGene00019801", "Q95ZQ4", "WBGene00020142", "A0A1T5HUK9", "WBGene00013732", "H2L0K0", "WBGene00020135", "O02168", "WBGene00020633", "Q9N501", "WBGene00021527", "species_76577", "Q9XUY2", "WBGene00010115", "P45894", "WBGene00019801", "Q95ZQ4", "WBGene00020142", "A0A1T5HUK9", "WBGene00013732", "H2L0K0", "WBGene00020135", "O02168", "WBGene00020633", "Q9N501", "WBGene00021527", "Q9N4D6", "WBGene00022279" ] }, "reaction_10503263": { "compartment": "compartment_5460", "id": "reaction_10503263", "reactome": "R-CEL-70609", "name": "glutamine + H2O => glutamate + NH4+ [GLS]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113522", "species_113521" ], "products": [ "species_113561", "species_113552" ], "modifiers": [ [ "species_10503260", "catalyst" ] ], "additional_components": [ "U4PRW7", "WBGene00007480", "Q19013", "WBGene00008435", "Q93650", "WBGene00009271" ] }, "reaction_10563027": { "compartment": "compartment_70101", "id": "reaction_10563027", "reactome": "R-CEL-6803875", "name": "SFN dimer binds CDK1 and CCNB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10563023", "species_10507049" ], "products": [ "species_10563025" ], "modifiers": [], "additional_components": [ "Q10653", "WBGene00000865", "Q9BLB5", "WBGene00000867", "O45926", "WBGene00000866", "P34556", "WBGene00000405", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "Q10653", "WBGene00000865", "Q9BLB5", "WBGene00000867", "O45926", "WBGene00000866", "P34556", "WBGene00000405" ] }, "reaction_10563029": { "compartment": "compartment_70101", "id": "reaction_10563029", "reactome": "R-CEL-6803890", "name": "SFN dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10507047" ], "products": [ "species_10507049" ], "modifiers": [], "additional_components": [ "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "P41932", "WBGene00003920", "Q20655", "WBGene00001502" ] }, "reaction_10569796": { "compartment": "compartment_7660", "id": "reaction_10569796", "reactome": "R-CEL-8952996", "name": "E2F7 forms homodimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10569792" ], "products": [ "species_10569794" ], "modifiers": [], "additional_components": [ "WBGene00009899", "Q20619", "WBGene00009899" ] }, "reaction_10569802": { "compartment": "compartment_7660", "id": "reaction_10569802", "reactome": "R-CEL-8953013", "name": "E2F7 binds E2F8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10569798", "species_10569792" ], "products": [ "species_10569800" ], "modifiers": [], "additional_components": [ "WBGene00009899", "WBGene00009899", "Q20619", "WBGene00009899" ] }, "reaction_10569806": { "compartment": "compartment_7660", "id": "reaction_10569806", "reactome": "R-CEL-8953037", "name": "E2F8 forms homodimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10569798" ], "products": [ "species_10569804" ], "modifiers": [], "additional_components": [ "WBGene00009899", "Q20619", "WBGene00009899" ] }, "reaction_10517733": { "compartment": "compartment_984", "id": "reaction_10517733", "reactome": "R-CEL-265456", "name": "NPC1L1 inactivation by ezetimibe", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_265479", "species_10517729" ], "products": [ "species_10517731" ], "modifiers": [], "additional_components": [ "P34389", "WBGene00003562", "Q19127", "WBGene00003561", "P34389", "WBGene00003562", "Q19127", "WBGene00003561", "species_265479" ] }, "reaction_10569030": { "compartment": "compartment_70101", "id": "reaction_10569030", "reactome": "R-CEL-8950780", "name": "p-Y705-STAT3 binds p-Y693-STAT4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10568972", "species_10531883" ], "products": [ "species_10569014" ], "modifiers": [], "additional_components": [ "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111" ] }, "reaction_10569018": { "compartment": "compartment_70101", "id": "reaction_10569018", "reactome": "R-CEL-8950724", "name": "p-Y705-STAT3:p-Y693-STAT4 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10569014" ], "products": [ "species_10569016" ], "modifiers": [], "additional_components": [ "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111" ] }, "reaction_10520825": { "compartment": "compartment_984", "id": "reaction_10520825", "reactome": "R-CEL-390641", "name": "ADRA1A,B,D bind ADR,NAd", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10519575", "species_390627" ], "products": [ "species_10519581" ], "modifiers": [ [ "species_10520823", "catalyst" ], [ "species_10520821", "inhibitor" ] ], "additional_components": [ "WBGene00008890", "species_209794", "species_209789", "species_209794", "species_209789", "G5EBX8", "WBGene00008890", "G5EBX8", "WBGene00008890", "G5EBX8", "WBGene00008890" ] }, "reaction_10520831": { "compartment": "compartment_984", "id": "reaction_10520831", "reactome": "R-CEL-390663", "name": "ADRA2A,B,C bind ADR,NAd", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_390627", "species_10519747" ], "products": [ "species_10519749" ], "modifiers": [], "additional_components": [ "species_209794", "species_209789", "O02213", "WBGene00004777", "Q19084", "WBGene00017157", "O02213", "WBGene00004777", "Q19084", "WBGene00017157", "species_209794", "species_209789" ] }, "reaction_10512688": { "compartment": "compartment_7660", "id": "reaction_10512688", "reactome": "R-CEL-187959", "name": "Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10512672" ], "products": [ "species_113582", "species_10512685" ], "modifiers": [ [ "species_10512672", "catalyst" ] ], "additional_components": [ "O61847", "WBGene00019362", "A5HWA8", "WBGene00001162", "O61847", "WBGene00019362", "A5HWA8", "WBGene00001162", "O61847", "WBGene00019362", "A5HWA8", "WBGene00001162" ] }, "reaction_10512674": { "compartment": "compartment_7660", "id": "reaction_10512674", "reactome": "R-CEL-187937", "name": "Association of Cyclin A:phospho-Cdk2(Thr 160) with E2F1/E2F3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502089", "species_10502278" ], "products": [ "species_10512672" ], "modifiers": [], "additional_components": [ "WBGene00001162", "O61847", "WBGene00019362", "O61847", "WBGene00019362", "A5HWA8", "WBGene00001162" ] }, "reaction_10565857": { "compartment": "compartment_70101", "id": "reaction_10565857", "reactome": "R-CEL-8857925", "name": "Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10513555" ], "products": [ "species_10565838", "species_29370" ], "modifiers": [ [ "species_10565854", "catalyst" ], [ "species_1806240", "catalyst" ] ], "additional_components": [] }, "reaction_10537250": { "compartment": "compartment_876", "id": "reaction_10537250", "reactome": "R-CEL-1676082", "name": "PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_392417" ], "products": [ "species_29370", "species_179856" ], "modifiers": [ [ "species_10537051", "catalyst" ] ], "additional_components": [ "WBGene00004087" ] }, "reaction_10537082": { "compartment": "compartment_876", "id": "reaction_10537082", "reactome": "R-CEL-1675776", "name": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806240", "species_113592" ], "products": [ "species_29370", "species_179856" ], "modifiers": [ [ "species_10537079", "catalyst" ] ], "additional_components": [ "Q9BL73", "WBGene00004088" ] }, "reaction_10564090": { "compartment": "compartment_70101", "id": "reaction_10564090", "reactome": "R-CEL-6811504", "name": "AKT1 dephosphorylation by PP2A-B56-beta,gamma", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10513843" ], "products": [ "species_10520798", "species_29372" ], "modifiers": [ [ "species_10564085", "catalyst" ], [ "species_1806240", "inhibitor" ] ], "additional_components": [ "Q9XTG7", "WBGene00000103", "G4S4W1", "WBGene00016980", "Q17941", "WBGene00000102", "G4S4W1", "WBGene00016980", "Q17941", "WBGene00000102", "Q9XTG7", "WBGene00000103", "O18178", "WBGene00012348", "A9UJN4", "WBGene00007554" ] }, "reaction_10543901": { "compartment": "compartment_70101", "id": "reaction_10543901", "reactome": "R-CEL-2316434", "name": "PI3K phosphorylates PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10543898", "catalyst" ] ], "additional_components": [ "Q94125", "WBGene00000090", "G5EDP9", "WBGene00000001", "P29355", "WBGene00004774", "G5EDJ4", "WBGene00004928", "E6N0V1", "WBGene00018819", "species_29438", "Q03206", "ced-10", "Q94124", "WBGene00004287", "Q9BL44", "WBGene00022177", "Q9XVQ7", "WBGene00008711", "A0A486WY88", "WBGene00010631", "species_1254400", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "A0A1I6CMA1", "WBGene00020678", "G5EGT9", "WBGene00003007", "P24348", "WBGene00002299", "species_179838", "Q9N413", "WBGene00004249" ] }, "reaction_10513621": { "compartment": "compartment_70101", "id": "reaction_10513621", "reactome": "R-CEL-195283", "name": "Phosphorylation of phospho- (Ser45, Thr41) beta-catenin at Ser37 by GSK-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10513614", "species_113592" ], "products": [ "species_29370", "species_10513618" ], "modifiers": [ [ "species_10513614", "catalyst" ] ], "additional_components": [ "Q21227", "WBGene00000156", "Q9U2Q9", "WBGene00001746", "Q09595", "WBGene00010991", "Q93372", "WBGene00010991", "P42168", "WBGene00002202", "O62090", "WBGene00004202", "O44326", "WBGene00001979", "O44326", "WBGene00001979", "Q21227", "WBGene00000156", "Q9U2Q9", "WBGene00001746", "Q09595", "WBGene00010991", "Q93372", "WBGene00010991", "P42168", "WBGene00002202", "O62090", "WBGene00004202", "Q21227", "WBGene00000156", "Q9U2Q9", "WBGene00001746", "Q09595", "WBGene00010991", "Q93372", "WBGene00010991", "P42168", "WBGene00002202", "O62090", "WBGene00004202", "O44326", "WBGene00001979" ] }, "reaction_10513640": { "compartment": "compartment_70101", "id": "reaction_10513640", "reactome": "R-CEL-195318", "name": "Phosphorylation of beta-catenin at Ser45 by CK1 alpha", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10513635" ], "products": [ "species_29370", "species_10513625" ], "modifiers": [ [ "species_10513635", "catalyst" ] ], "additional_components": [ "O44326", "WBGene00001979", "Q21227", "WBGene00000156", "Q9U2Q9", "WBGene00001746", "Q09595", "WBGene00010991", "Q93372", "WBGene00010991", "P42168", "WBGene00002202", "O62090", "WBGene00004202", "Q21227", "WBGene00000156", "Q9U2Q9", "WBGene00001746", "Q09595", "WBGene00010991", "Q93372", "WBGene00010991", "P42168", "WBGene00002202", "O62090", "WBGene00004202", "O44326", "WBGene00001979", "O44326", "WBGene00001979", "Q21227", "WBGene00000156", "Q9U2Q9", "WBGene00001746", "Q09595", "WBGene00010991", "Q93372", "WBGene00010991", "P42168", "WBGene00002202", "O62090", "WBGene00004202" ] }, "reaction_10513628": { "compartment": "compartment_70101", "id": "reaction_10513628", "reactome": "R-CEL-195287", "name": "Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10513625" ], "products": [ "species_10513614", "species_29370" ], "modifiers": [ [ "species_10513625", "catalyst" ] ], "additional_components": [ "Q21227", "WBGene00000156", "Q9U2Q9", "WBGene00001746", "Q09595", "WBGene00010991", "Q93372", "WBGene00010991", "P42168", "WBGene00002202", "O62090", "WBGene00004202", "O44326", "WBGene00001979", "Q21227", "WBGene00000156", "Q9U2Q9", "WBGene00001746", "Q09595", "WBGene00010991", "Q93372", "WBGene00010991", "P42168", "WBGene00002202", "O62090", "WBGene00004202", "O44326", "WBGene00001979", "Q21227", "WBGene00000156", "Q9U2Q9", "WBGene00001746", "Q09595", "WBGene00010991", "Q93372", "WBGene00010991", "P42168", "WBGene00002202", "O62090", "WBGene00004202", "O44326", "WBGene00001979" ] }, "reaction_10513631": { "compartment": "compartment_70101", "id": "reaction_10513631", "reactome": "R-CEL-195300", "name": "Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10513618" ], "products": [ "species_10513598", "species_29370" ], "modifiers": [ [ "species_10513618", "catalyst" ] ], "additional_components": [ "O44326", "WBGene00001979", "Q21227", "WBGene00000156", "Q9U2Q9", "WBGene00001746", "Q09595", "WBGene00010991", "Q93372", "WBGene00010991", "P42168", "WBGene00002202", "O62090", "WBGene00004202", "Q21227", "WBGene00000156", "Q9U2Q9", "WBGene00001746", "Q09595", "WBGene00010991", "Q93372", "WBGene00010991", "P42168", "WBGene00002202", "O62090", "WBGene00004202", "O44326", "WBGene00001979", "O44326", "WBGene00001979", "Q21227", "WBGene00000156", "Q9U2Q9", "WBGene00001746", "Q09595", "WBGene00010991", "Q93372", "WBGene00010991", "P42168", "WBGene00002202", "O62090", "WBGene00004202" ] }, "reaction_10568784": { "compartment": "compartment_7660", "id": "reaction_10568784", "reactome": "R-CEL-8944349", "name": "TLE tetramers bind TCF/LEF at WNT promoters", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10547166", "species_10568780" ], "products": [ "species_10568782" ], "modifiers": [], "additional_components": [ "O02482", "WBGene00006773", "Q10666", "WBGene00004077", "Q10666", "WBGene00004077", "O02482", "WBGene00006773" ] }, "reaction_10549443": { "compartment": "compartment_7660", "id": "reaction_10549443", "reactome": "R-CEL-4641229", "name": "TLE oligomerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10547150" ], "products": [ "species_10547166" ], "modifiers": [], "additional_components": [ "WBGene00006773", "O02482", "WBGene00006773" ] }, "reaction_10551337": { "compartment": "compartment_7660", "id": "reaction_10551337", "reactome": "R-CEL-5334050", "name": "TCF7L2/TCF7L1 bind CTBP1 to repress WNT target genes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546301", "species_10547139" ], "products": [ "species_10551335" ], "modifiers": [], "additional_components": [ "WBGene00006424", "WBGene00004077", "Q10666", "WBGene00004077", "Q20595", "WBGene00006424" ] }, "reaction_10542756": { "compartment": "compartment_70101", "id": "reaction_10542756", "reactome": "R-CEL-2130279", "name": "Association of beta-catenin with the RBX1:SCF(beta-TrCP1) ubiquitin ligase complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10516333", "species_10513603" ], "products": [ "species_10542754" ], "modifiers": [], "additional_components": [ "G5ECU1", "WBGene00004807", "Q17389", "WBGene00000836", "Q23457", "WBGene00004320", "Q21227", "WBGene00000156", "Q9U2Q9", "WBGene00001746", "Q09595", "WBGene00010991", "Q93372", "WBGene00010991", "P42168", "WBGene00002202", "O62090", "WBGene00004202", "O44326", "WBGene00001979", "Q21227", "WBGene00000156", "Q9U2Q9", "WBGene00001746", "Q09595", "WBGene00010991", "Q93372", "WBGene00010991", "P42168", "WBGene00002202", "O62090", "WBGene00004202", "O44326", "WBGene00001979", "G5ECU1", "WBGene00004807", "Q17389", "WBGene00000836", "Q23457", "WBGene00004320" ] }, "reaction_10513637": { "compartment": "compartment_70101", "id": "reaction_10513637", "reactome": "R-CEL-195304", "name": "Association of beta-catenin with the destruction complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10513587", "species_10513633" ], "products": [ "species_10513635" ], "modifiers": [], "additional_components": [ "Q21227", "WBGene00000156", "Q9U2Q9", "WBGene00001746", "Q09595", "WBGene00010991", "Q93372", "WBGene00010991", "P42168", "WBGene00002202", "O62090", "WBGene00004202", "WBGene00001979", "O44326", "WBGene00001979", "Q21227", "WBGene00000156", "Q9U2Q9", "WBGene00001746", "Q09595", "WBGene00010991", "Q93372", "WBGene00010991", "P42168", "WBGene00002202", "O62090", "WBGene00004202" ] }, "reaction_10550824": { "compartment": "compartment_70101", "id": "reaction_10550824", "reactome": "R-CEL-5229343", "name": "AXIN is phosphorylated in the destruction complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10515030" ], "products": [ "species_29370", "species_10513587" ], "modifiers": [ [ "species_10515030", "catalyst" ] ], "additional_components": [ "Q21227", "WBGene00000156", "Q9U2Q9", "WBGene00001746", "Q09595", "WBGene00010991", "Q93372", "WBGene00010991", "P42168", "WBGene00002202", "O62090", "WBGene00004202", "Q21227", "WBGene00000156", "Q9U2Q9", "WBGene00001746", "Q09595", "WBGene00010991", "Q93372", "WBGene00010991", "P42168", "WBGene00002202", "O62090", "WBGene00004202", "Q21227", "WBGene00000156", "Q9U2Q9", "WBGene00001746", "Q09595", "WBGene00010991", "Q93372", "WBGene00010991", "P42168", "WBGene00002202", "O62090", "WBGene00004202" ] }, "reaction_10513608": { "compartment": "compartment_70101", "id": "reaction_10513608", "reactome": "R-CEL-195275", "name": "Phosphorylation of APC component of the destruction complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10513598", "species_113592" ], "products": [ "species_29370", "species_10513603" ], "modifiers": [ [ "species_10513598", "catalyst" ] ], "additional_components": [ "Q21227", "WBGene00000156", "Q9U2Q9", "WBGene00001746", "Q09595", "WBGene00010991", "Q93372", "WBGene00010991", "P42168", "WBGene00002202", "O62090", "WBGene00004202", "O44326", "WBGene00001979", "Q21227", "WBGene00000156", "Q9U2Q9", "WBGene00001746", "Q09595", "WBGene00010991", "Q93372", "WBGene00010991", "P42168", "WBGene00002202", "O62090", "WBGene00004202", "O44326", "WBGene00001979", "Q21227", "WBGene00000156", "Q9U2Q9", "WBGene00001746", "Q09595", "WBGene00010991", "Q93372", "WBGene00010991", "P42168", "WBGene00002202", "O62090", "WBGene00004202", "O44326", "WBGene00001979" ] }, "reaction_10513610": { "compartment": "compartment_70101", "id": "reaction_10513610", "reactome": "R-CEL-195280", "name": "Dissociation of beta-catenin from Axin and association of beta catenin with phospho-(20 aa) APC in the detruction complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10513603" ], "products": [ "species_10513603" ], "modifiers": [], "additional_components": [ "Q21227", "WBGene00000156", "Q9U2Q9", "WBGene00001746", "Q09595", "WBGene00010991", "Q93372", "WBGene00010991", "P42168", "WBGene00002202", "O62090", "WBGene00004202", "O44326", "WBGene00001979", "Q21227", "WBGene00000156", "Q9U2Q9", "WBGene00001746", "Q09595", "WBGene00010991", "Q93372", "WBGene00010991", "P42168", "WBGene00002202", "O62090", "WBGene00004202", "O44326", "WBGene00001979" ] }, "reaction_10542762": { "compartment": "compartment_70101", "id": "reaction_10542762", "reactome": "R-CEL-2130282", "name": "Degradation of ubiquitinated beta catenin by the proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10542758" ], "products": [ "species_10516333", "species_10542760", "species_10502375" ], "modifiers": [ [ "species_10502572", "catalyst" ] ], "additional_components": [ "Q21227", "WBGene00000156", "Q9U2Q9", "WBGene00001746", "Q09595", "WBGene00010991", "Q93372", "WBGene00010991", "P42168", "WBGene00002202", "O62090", "WBGene00004202", "O44326", "WBGene00001979", "G5ECU1", "WBGene00004807", "Q17389", "WBGene00000836", "Q23457", "WBGene00004320", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "G5ECU1", "WBGene00004807", "Q17389", "WBGene00000836", "Q23457", "WBGene00004320", "Q21227", "WBGene00000156", "Q9U2Q9", "WBGene00001746", "Q09595", "WBGene00010991", "Q93372", "WBGene00010991", "P42168", "WBGene00002202", "O62090", "WBGene00004202", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "P91477", "WBGene00003950", "Q95PZ7", "WBGene00013435", "Q18115", "WBGene00004459", "O62102", "WBGene00003948", "O17071", "WBGene00004504", "Q10920", "WBGene00016623", "P34286", "WBGene00003952", "Q9XTT9", "WBGene00004506", "Q23449", "WBGene00004468", "Q95005", "WBGene00003925", "P46502", "WBGene00004503", "O61792", "WBGene00004464", "O17586", "WBGene00003922", "O76371", "WBGene00004505", "Q20585", "WBGene00004463", "Q95008", "WBGene00003926", "Q18787", "WBGene00004501", "Q20058", "WBGene00009445", "Q9N599", "WBGene00003924", "O16368", "WBGene00004502", "O61742", "WBGene00004466", "Q09583", "WBGene00003928", "Q966I8", "WBGene00003947", "Q04908", "WBGene00004460", "Q9XUV0", "WBGene00003951", "Q27488", "WBGene00003923", "Q9GZH5", "WBGene00004458", "O44156", "WBGene00003927", "Q22253", "WBGene00004465", "O76577", "WBGene00004467", "P90868", "WBGene00003953", "Q19324", "WBGene00004461", "Q17971", "WBGene00007588", "Q23237", "WBGene00003949", "Q20938", "WBGene00004462" ] }, "reaction_10542764": { "compartment": "compartment_70101", "id": "reaction_10542764", "reactome": "R-CEL-2130286", "name": "Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502375", "species_10542754" ], "products": [ "species_10542758" ], "modifiers": [], "additional_components": [ "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "Q21227", "WBGene00000156", "Q9U2Q9", "WBGene00001746", "Q09595", "WBGene00010991", "Q93372", "WBGene00010991", "P42168", "WBGene00002202", "O62090", "WBGene00004202", "O44326", "WBGene00001979", "G5ECU1", "WBGene00004807", "Q17389", "WBGene00000836", "Q23457", "WBGene00004320", "Q21227", "WBGene00000156", "Q9U2Q9", "WBGene00001746", "Q09595", "WBGene00010991", "Q93372", "WBGene00010991", "P42168", "WBGene00002202", "O62090", "WBGene00004202", "O44326", "WBGene00001979", "G5ECU1", "WBGene00004807", "Q17389", "WBGene00000836", "Q23457", "WBGene00004320", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727" ] }, "reaction_10569984": { "compartment": "compartment_70101", "id": "reaction_10569984", "reactome": "R-CEL-8955760", "name": "PGM2L1:Mg2+ phosphorylates G6P to G1,6BP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30537", "species_29800" ], "products": [ "species_70106", "species_8955759", "species_29728" ], "modifiers": [ [ "species_10502853", "catalyst" ] ], "additional_components": [ "O45934", "WBGene00012803", "species_114632" ] }, "reaction_10504330": { "compartment": "compartment_70101", "id": "reaction_10504330", "reactome": "R-CEL-71802", "name": "D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_29512" ], "products": [ "species_29370", "species_30533" ], "modifiers": [ [ "species_10504327", "catalyst" ], [ "species_30533", "catalyst" ] ], "additional_components": [ "Q21122", "WBGene00019295", "Q9N590", "WBGene00022456" ] }, "reaction_10502842": { "compartment": "compartment_70101", "id": "reaction_10502842", "reactome": "R-CEL-70262", "name": "Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_30533" ], "products": [ "species_29372", "species_29512" ], "modifiers": [ [ "species_10502839", "catalyst" ] ], "additional_components": [ "Q9N590", "WBGene00022456", "Q21122", "WBGene00019295" ] }, "reaction_10504194": { "compartment": "compartment_70101", "id": "reaction_10504194", "reactome": "R-CEL-71660", "name": "2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30485" ], "products": [ "species_29356", "species_29492" ], "modifiers": [ [ "species_10503109", "catalyst" ] ], "additional_components": [ "Q27527", "WBGene00011884", "species_114632" ] }, "reaction_10557538": { "compartment": "compartment_12045", "id": "reaction_10557538", "reactome": "R-CEL-5696021", "name": "ADPGK:Mg2+ phosphorylates Glc to G6P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29370", "species_70113" ], "products": [ "species_30537", "species_76577" ], "modifiers": [ [ "species_10557535", "catalyst" ] ], "additional_components": [ "species_114632", "Q86S40", "WBGene00016810" ] }, "reaction_10504004": { "compartment": "compartment_70101", "id": "reaction_10504004", "reactome": "R-CEL-71496", "name": "D-fructose 1,6-bisphosphate <=> dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30014" ], "products": [ "species_29578", "species_75970" ], "modifiers": [ [ "species_10503999", "catalyst" ] ], "additional_components": [ "P54216", "WBGene00011474", "P46563", "WBGene00017166" ] }, "reaction_10503048": { "compartment": "compartment_70101", "id": "reaction_10503048", "reactome": "R-CEL-70467", "name": "D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_29512" ], "products": [ "species_30014", "species_29370" ], "modifiers": [ [ "species_10503045", "catalyst" ], [ "species_30533", "catalyst" ], [ "species_29370", "catalyst" ], [ "species_76577", "catalyst" ], [ "species_113592", "inhibitor" ], [ "species_76190", "inhibitor" ] ], "additional_components": [ "Q9TZL8", "WBGene00022199", "Q27483", "WBGene00008230" ] }, "reaction_10511375": { "compartment": "compartment_13231", "id": "reaction_10511375", "reactome": "R-CEL-170825", "name": "glucokinase [nucleoplasm] => glucokinase [cytosol]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10511373" ], "products": [ "species_10502937" ], "modifiers": [], "additional_components": [ "Q19440", "WBGene00008780", "Q9N4A5", "WBGene00022306", "Q9XU15", "WBGene00010416", "Q9N4A5", "WBGene00022306", "Q9XU15", "WBGene00010416", "Q19440", "WBGene00008780" ] }, "reaction_10502958": { "compartment": "compartment_70101", "id": "reaction_10502958", "reactome": "R-CEL-70420", "name": "HK1,2,3,GCK phosphorylate Glc to form G6P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_70113" ], "products": [ "species_70106", "species_29370", "species_30537" ], "modifiers": [ [ "species_10502955", "catalyst" ] ], "additional_components": [ "Q19440", "WBGene00008780", "Q9N4A5", "WBGene00022306", "Q9XU15", "WBGene00010416" ] }, "reaction_10504334": { "compartment": "compartment_70101", "id": "reaction_10504334", "reactome": "R-CEL-71850", "name": "1,3-bisphospho-D-glycerate + ADP <=> 3-phospho-D-glycerate + ATP", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29370", "species_29800" ], "products": [ "species_113592", "species_29728" ], "modifiers": [ [ "species_10503093", "catalyst" ] ], "additional_components": [ "species_114632", "P91427", "WBGene00020185" ] }, "reaction_10502997": { "compartment": "compartment_70101", "id": "reaction_10502997", "reactome": "R-CEL-70449", "name": "D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29372", "species_29578", "species_29360" ], "products": [ "species_70106", "species_29800", "species_73473" ], "modifiers": [ [ "species_10502994", "catalyst" ] ], "additional_components": [ "P04970", "WBGene00001683", "P17329", "WBGene00001684", "P17330", "WBGene00001685", "P17331", "WBGene00001686" ] }, "reaction_10562107": { "compartment": "compartment_70101", "id": "reaction_10562107", "reactome": "R-CEL-6799604", "name": "GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_449701" ], "products": [ "species_29512", "species_31633" ], "modifiers": [ [ "species_10562104", "catalyst" ] ], "additional_components": [ "Q9XVJ2", "WBGene00011399" ] }, "reaction_10504221": { "compartment": "compartment_70101", "id": "reaction_10504221", "reactome": "R-CEL-71670", "name": "phosphoenolpyruvate + ADP => pyruvate + ATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29370", "species_29492" ], "products": [ "species_113592", "species_29398" ], "modifiers": [ [ "species_10504218", "catalyst" ], [ "species_30014", "catalyst" ], [ "species_76183", "inhibitor" ], [ "species_29358", "inhibitor" ], [ "species_30389", "inhibitor" ] ], "additional_components": [ "species_114632", "species_74126", "B7WNA0", "WBGene00009126", "Q23539", "WBGene00014001" ] }, "reaction_10503007": { "compartment": "compartment_70101", "id": "reaction_10503007", "reactome": "R-CEL-70454", "name": "dihydroxyacetone phosphate <=> D-glyceraldehyde 3-phosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_75970" ], "products": [ "species_29578" ], "modifiers": [ [ "species_10503004", "catalyst" ] ], "additional_components": [ "Q10657", "WBGene00006601" ] }, "reaction_10529025": { "compartment": "compartment_5460", "id": "reaction_10529025", "reactome": "R-CEL-916855", "name": "PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_916850", "species_113594" ], "products": [ "species_880046", "species_113552" ], "modifiers": [ [ "species_10529022", "catalyst" ] ], "additional_components": [ "CHEBI:33739", "Q21217", "WBGene00001794" ] }, "reaction_10528302": { "compartment": "compartment_5460", "id": "reaction_10528302", "reactome": "R-CEL-888548", "name": "ALDH5A1 dehydrogenates SUCCSA to SUCCA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113526", "species_880046", "species_113521" ], "products": [ "species_113529", "species_29362", "species_113536" ], "modifiers": [ [ "species_10528299", "catalyst" ] ], "additional_components": [ "O02266", "WBGene00000113" ] }, "reaction_10550736": { "compartment": "compartment_7660", "id": "reaction_10550736", "reactome": "R-CEL-5225602", "name": "WDR5 binds Me2sR3-replicative histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10550011", "species_10550698" ], "products": [ "species_10550734" ], "modifiers": [], "additional_components": [ "WBGene00006474", "Q17963", "WBGene00006474" ] }, "reaction_10550706": { "compartment": "compartment_7660", "id": "reaction_10550706", "reactome": "R-CEL-5218952", "name": "PRMT5:WDR77, PRMT7 methylate arginine-3 of histone H3 (H3R2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10546551" ], "products": [ "species_77502", "species_10550698" ], "modifiers": [ [ "species_10550703", "catalyst" ] ], "additional_components": [ "WBGene00012298" ] }, "reaction_10554499": { "compartment": "compartment_7660", "id": "reaction_10554499", "reactome": "R-CEL-5661126", "name": "PRMT1,PRMT6 methylate methyl-lysine-4 of histone H4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10550424" ], "products": [ "species_77502", "species_10554497" ], "modifiers": [ [ "species_10546564", "catalyst" ] ], "additional_components": [ "WBGene00001875", "WBGene00001875", "WBGene00013766" ] }, "reaction_10550740": { "compartment": "compartment_7660", "id": "reaction_10550740", "reactome": "R-CEL-5225649", "name": "RBBP7 binds histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10517096", "species_10546551" ], "products": [ "species_10550738" ], "modifiers": [ [ "species_10550698", "inhibitor" ] ], "additional_components": [ "P90916", "WBGene00003036", "P90917", "WBGene00004312", "P90916", "WBGene00003036", "P90917", "WBGene00004312" ] }, "reaction_10550506": { "compartment": "compartment_7660", "id": "reaction_10550506", "reactome": "R-CEL-5205867", "name": "PRMT1 methylates arginine-12 of histone H2A (H2AR11)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10550491" ], "products": [ "species_77502", "species_10550504" ], "modifiers": [ [ "species_10546564", "catalyst" ] ], "additional_components": [ "WBGene00013766" ] }, "reaction_10550427": { "compartment": "compartment_7660", "id": "reaction_10550427", "reactome": "R-CEL-5205798", "name": "PRMT1,PRMT6 methylate arginine-4 of histone H4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10506929" ], "products": [ "species_77502", "species_10550424" ], "modifiers": [ [ "species_10546564", "catalyst" ] ], "additional_components": [ "WBGene00001875", "WBGene00001875", "WBGene00013766" ] }, "reaction_10554048": { "compartment": "compartment_70101", "id": "reaction_10554048", "reactome": "R-CEL-5634802", "name": "MECOM (KMT8E), PRDM16 (KMT8F) methylate lysine-10 of replicative histone H3 (H3K9)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71284", "species_10554034" ], "products": [ "species_10554038", "species_71285" ], "modifiers": [ [ "species_10554043", "catalyst" ] ], "additional_components": [ "WBGene00001207" ] }, "reaction_10554160": { "compartment": "compartment_7660", "id": "reaction_10554160", "reactome": "R-CEL-5638157", "name": "WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C), ASH1L methylate methyl-lysine-37 of histone H3 (H3K36)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10549582" ], "products": [ "species_77502", "species_10554153" ], "modifiers": [ [ "species_10549759", "catalyst" ] ], "additional_components": [ "Q23084", "WBGene00022499", "Q8I4F7", "WBGene00044070", "Q9XV44", "WBGene00009370", "Q09415", "WBGene00011068" ] }, "reaction_10549762": { "compartment": "compartment_7660", "id": "reaction_10549762", "reactome": "R-CEL-4827383", "name": "WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C) methylate lysine-37 of histone H3 (H3K36)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10546551" ], "products": [ "species_77502", "species_10549582" ], "modifiers": [ [ "species_10549759", "catalyst" ] ], "additional_components": [ "Q23084", "WBGene00022499", "Q8I4F7", "WBGene00044070", "Q9XV44", "WBGene00009370", "Q09415", "WBGene00011068" ] }, "reaction_10554178": { "compartment": "compartment_7660", "id": "reaction_10554178", "reactome": "R-CEL-5649764", "name": "DOT1L (KMT4) methylates methyl-lysine-80 of histone H3 (H3K79)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10554165" ], "products": [ "species_77502", "species_10554170" ], "modifiers": [ [ "species_10554175", "catalyst" ] ], "additional_components": [ "WBGene00021474" ] }, "reaction_10550023": { "compartment": "compartment_7660", "id": "reaction_10550023", "reactome": "R-CEL-5159245", "name": "SETD3, SETD7 (KMT7), WHSC1L1 (KMT3F), Core MLL complex methylate lysine-5 of histone H3 (H3K4)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10546551" ], "products": [ "species_77502", "species_10546549" ], "modifiers": [ [ "species_10550020", "catalyst" ] ], "additional_components": [ "Q9BL48", "WBGene00022173", "Q10661", "WBGene00001088", "G5EFZ3", "WBGene00012458", "Q09309", "WBGene00017683", "Q18221", "WBGene00004782", "G5EGI1", "WBGene00011729", "Q17963", "WBGene00006474" ] }, "reaction_10552342": { "compartment": "compartment_7660", "id": "reaction_10552342", "reactome": "R-CEL-5423038", "name": "SETD8 (KMT5A) methylates lysine-21 of histone H4 (H4K20)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10506929" ], "products": [ "species_77502", "species_10543366" ], "modifiers": [ [ "species_10543801", "catalyst" ] ], "additional_components": [ "WBGene00001875", "WBGene00001875", "WBGene00004781" ] }, "reaction_10554185": { "compartment": "compartment_7660", "id": "reaction_10554185", "reactome": "R-CEL-5649799", "name": "DOT1L (KMT4) methylates dimethyl-lysine-80 of histone H3 (H3K79)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10554170" ], "products": [ "species_77502", "species_10554183" ], "modifiers": [ [ "species_10554175", "catalyst" ] ], "additional_components": [ "WBGene00021474" ] }, "reaction_10550985": { "compartment": "compartment_7660", "id": "reaction_10550985", "reactome": "R-CEL-5244692", "name": "Core MLL complex, SMYD3, PRDM9 methylate dimethyl-lysine-5 of histone H3 (H3K4)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10549629" ], "products": [ "species_77502", "species_10550978" ], "modifiers": [ [ "species_10550982", "catalyst" ], [ "species_10550471", "inhibitor" ] ], "additional_components": [ "Q10661", "WBGene00001088", "G5EFZ3", "WBGene00012458", "Q09309", "WBGene00017683", "Q18221", "WBGene00004782", "G5EGI1", "WBGene00011729", "Q17963", "WBGene00006474", "Q09415", "WBGene00011068" ] }, "reaction_10549737": { "compartment": "compartment_7660", "id": "reaction_10549737", "reactome": "R-CEL-4827382", "name": "SUV39H1 (KMT1A), SUV39H2 (KTM1B), SETDB1 (KMT1E), SETDB2 (KMT1F) methylate dimethyl-lysine-10 of histone H3 (H3K9)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10549601" ], "products": [ "species_77502", "species_10549722" ], "modifiers": [ [ "species_10549734", "catalyst" ] ], "additional_components": [ "P34544", "WBGene00019883", "Q18221", "WBGene00004782" ] }, "reaction_10554187": { "compartment": "compartment_7660", "id": "reaction_10554187", "reactome": "R-CEL-5649801", "name": "DOT1L (KMT4) methylates lysine-80 of histone H3 (H3K79)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10546551" ], "products": [ "species_77502", "species_10554165" ], "modifiers": [ [ "species_10554175", "catalyst" ] ], "additional_components": [ "WBGene00021474" ] }, "reaction_10554110": { "compartment": "compartment_7660", "id": "reaction_10554110", "reactome": "R-CEL-5637686", "name": "WHSC1L1 (KMT3F), Core MLL complex, SMYD3 (KMT3E) methylate methyl-lysine-5 of histone H3 (H3K4)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10546549" ], "products": [ "species_77502", "species_10549629" ], "modifiers": [ [ "species_10554107", "catalyst" ] ], "additional_components": [ "Q9BL48", "WBGene00022173", "Q10661", "WBGene00001088", "G5EFZ3", "WBGene00012458", "Q09309", "WBGene00017683", "Q18221", "WBGene00004782", "G5EGI1", "WBGene00011729", "Q17963", "WBGene00006474", "Q09415", "WBGene00011068" ] }, "reaction_10549670": { "compartment": "compartment_7660", "id": "reaction_10549670", "reactome": "R-CEL-4754187", "name": "KDM6A, KDM6B, KDM7A demethylate Me2K28-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113671", "species_113685", "species_10549648" ], "products": [ "species_29478", "species_10549653", "species_159942", "species_159939" ], "modifiers": [ [ "species_10549667", "catalyst" ] ], "additional_components": [ "Q19760", "WBGene00009089", "Q95QK3", "WBGene00017571", "Q20367", "WBGene00005013", "Q9GYI0", "WBGene00017920" ] }, "reaction_10554473": { "compartment": "compartment_7660", "id": "reaction_10554473", "reactome": "R-CEL-5661114", "name": "KDM2A, KDM2B, KDM4A demethylate Me2K37-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10554153", "species_113671", "species_113685" ], "products": [ "species_10549582", "species_29478", "species_159942", "species_159939" ], "modifiers": [ [ "species_10549596", "catalyst" ] ], "additional_components": [ "Q95Q98", "WBGene00020821", "Q9U297", "WBGene00012982" ] }, "reaction_10549608": { "compartment": "compartment_7660", "id": "reaction_10549608", "reactome": "R-CEL-4724279", "name": "KDM4A, KDM4B, KDM4C, KDM4D demethylate Me2K10-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113671", "species_113685", "species_10549601" ], "products": [ "species_29478", "species_159942", "species_10549603", "species_159939" ], "modifiers": [ [ "species_10549594", "catalyst" ] ], "additional_components": [ "WBGene00012982" ] }, "reaction_10554475": { "compartment": "compartment_7660", "id": "reaction_10554475", "reactome": "R-CEL-5661115", "name": "KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate Me2K10-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113671", "species_113685", "species_10549601" ], "products": [ "species_29478", "species_159942", "species_10549603", "species_159939" ], "modifiers": [ [ "species_10549616", "catalyst" ] ], "additional_components": [ "Q9GYI0", "WBGene00017920", "Q20367", "WBGene00005013" ] }, "reaction_10549643": { "compartment": "compartment_7660", "id": "reaction_10549643", "reactome": "R-CEL-4754181", "name": "KDM5A-D demethylate Me2K5-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10549629", "species_113671", "species_113685" ], "products": [ "species_29478", "species_10546549", "species_159942", "species_159939" ], "modifiers": [ [ "species_10549634", "catalyst" ] ], "additional_components": [ "WBGene00004319" ] }, "reaction_10554477": { "compartment": "compartment_7660", "id": "reaction_10554477", "reactome": "R-CEL-5661116", "name": "KDM5A-D demethylate Me3K5-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113671", "species_113685", "species_10550978" ], "products": [ "species_10549629", "species_29478", "species_159942", "species_159939" ], "modifiers": [ [ "species_10549634", "catalyst" ] ], "additional_components": [ "WBGene00004319" ] }, "reaction_10549619": { "compartment": "compartment_7660", "id": "reaction_10549619", "reactome": "R-CEL-4724284", "name": "KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate MeK10-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113671", "species_113685", "species_10549603" ], "products": [ "species_10546551", "species_29478", "species_159942", "species_159939" ], "modifiers": [ [ "species_10549616", "catalyst" ] ], "additional_components": [ "Q9GYI0", "WBGene00017920", "Q20367", "WBGene00005013" ] }, "reaction_10554484": { "compartment": "compartment_7660", "id": "reaction_10554484", "reactome": "R-CEL-5661120", "name": "KDM4A, KDM4B, KDM4C, KDM4D, MINA demethylate Me3K10-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10549722", "species_113671", "species_113685" ], "products": [ "species_29478", "species_159942", "species_159939", "species_10549601" ], "modifiers": [ [ "species_10549594", "catalyst" ] ], "additional_components": [ "WBGene00012982" ] }, "reaction_10554486": { "compartment": "compartment_7660", "id": "reaction_10554486", "reactome": "R-CEL-5661121", "name": "KDM6A, KDM6B, KDM7A demethylate Me3K28-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10554189", "species_113671", "species_113685" ], "products": [ "species_29478", "species_159942", "species_159939", "species_10549648" ], "modifiers": [ [ "species_10549667", "catalyst" ] ], "additional_components": [ "Q19760", "WBGene00009089", "Q95QK3", "WBGene00017571", "Q20367", "WBGene00005013", "Q9GYI0", "WBGene00017920" ] }, "reaction_10552345": { "compartment": "compartment_7660", "id": "reaction_10552345", "reactome": "R-CEL-5423117", "name": "PHF8 demethylates MeK21-histone H4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113671", "species_10543366", "species_113685" ], "products": [ "species_29478", "species_159942", "species_159939", "species_10506929" ], "modifiers": [ [ "species_10543372", "catalyst" ] ], "additional_components": [ "WBGene00001875", "WBGene00001875", "WBGene00017920" ] }, "reaction_10554488": { "compartment": "compartment_7660", "id": "reaction_10554488", "reactome": "R-CEL-5661122", "name": "JMJD6 demethylates Me2R3-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113671", "species_10550469", "species_113685" ], "products": [ "species_29478", "species_10546774", "species_159942", "species_159939" ], "modifiers": [ [ "species_10549624", "catalyst" ] ], "additional_components": [ "WBGene00004205" ] }, "reaction_10554490": { "compartment": "compartment_7660", "id": "reaction_10554490", "reactome": "R-CEL-5661123", "name": "KDM1A, KDM1B demethylate Me2K5-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10549629" ], "products": [ "species_29478", "species_10546549" ], "modifiers": [ [ "species_10546556", "catalyst" ] ], "additional_components": [ "WBGene00000137" ] }, "reaction_10549627": { "compartment": "compartment_7660", "id": "reaction_10549627", "reactome": "R-CEL-4754176", "name": "JMJD6 demethylates MeR3-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113671", "species_10546774", "species_113685" ], "products": [ "species_10546551", "species_29478", "species_159942", "species_159939" ], "modifiers": [ [ "species_10549624", "catalyst" ] ], "additional_components": [ "WBGene00004205" ] }, "reaction_10554492": { "compartment": "compartment_7660", "id": "reaction_10554492", "reactome": "R-CEL-5661124", "name": "JMJD6 demethylates MeR4-HIST1H4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10550424", "species_113671", "species_113685" ], "products": [ "species_29478", "species_159942", "species_159939", "species_10506929" ], "modifiers": [ [ "species_10549624", "catalyst" ] ], "additional_components": [ "WBGene00001875", "WBGene00001875", "WBGene00004205" ] }, "reaction_10546559": { "compartment": "compartment_7660", "id": "reaction_10546559", "reactome": "R-CEL-3214912", "name": "KDM1A, KDM1B demethylate MeK5-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546549" ], "products": [ "species_10546551", "species_29478" ], "modifiers": [ [ "species_10546556", "catalyst" ] ], "additional_components": [ "WBGene00000137" ] }, "reaction_10549599": { "compartment": "compartment_7660", "id": "reaction_10549599", "reactome": "R-CEL-4722133", "name": "KDM2A, KDM2B, KDM4A demethylate MeK37-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10549582", "species_113671", "species_113685" ], "products": [ "species_10546551", "species_29478", "species_159942", "species_159939" ], "modifiers": [ [ "species_10549596", "catalyst" ] ], "additional_components": [ "Q95Q98", "WBGene00020821", "Q9U297", "WBGene00012982" ] }, "reaction_10554494": { "compartment": "compartment_7660", "id": "reaction_10554494", "reactome": "R-CEL-5661125", "name": "JMJD6 demethylates Me2sR4-HIST1H4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10550476", "species_113671", "species_113685" ], "products": [ "species_10550424", "species_29478", "species_159942", "species_159939" ], "modifiers": [ [ "species_10549624", "catalyst" ] ], "additional_components": [ "WBGene00001875", "WBGene00001875", "WBGene00004205" ] }, "reaction_10547753": { "compartment": "compartment_7660", "id": "reaction_10547753", "reactome": "R-CEL-3662318", "name": "Type B histone acetlytransferase complex acetylates histone H4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113560", "species_10506929" ], "products": [ "species_2485002", "species_10547743" ], "modifiers": [ [ "species_10547750", "catalyst" ] ], "additional_components": [ "WBGene00001875", "WBGene00001875", "Q21484", "WBGene00044069", "P90916", "WBGene00003036", "P90917", "WBGene00004312" ] }, "reaction_10547932": { "compartment": "compartment_7660", "id": "reaction_10547932", "reactome": "R-CEL-3662335", "name": "EP300 acetylates histone H2A, H2B, H3, H4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113560", "species_10547761" ], "products": [ "species_2485002", "species_10547929" ], "modifiers": [ [ "species_10532228", "catalyst" ] ], "additional_components": [ "WBGene00000366" ] }, "reaction_10547276": { "compartment": "compartment_7660", "id": "reaction_10547276", "reactome": "R-CEL-3318415", "name": "ATF2 acetylates histone H2B, H4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113560", "species_10547238" ], "products": [ "species_2485002", "species_10547273" ], "modifiers": [ [ "species_10510845", "catalyst" ] ], "additional_components": [ "P62784", "WBGene00001875", "Q27484", "WBGene00001915", "Q27876", "WBGene00001922", "Q27894", "WBGene00001878", "P04255", "WBGene00001885", "P04255", "WBGene00001885", "Q27484", "WBGene00001915", "Q27876", "WBGene00001922", "Q27894", "WBGene00001878", "P62784", "WBGene00001875", "WBGene00000223" ] }, "reaction_10548040": { "compartment": "compartment_7660", "id": "reaction_10548040", "reactome": "R-CEL-3769447", "name": "HDAC1:2-containing complex deacetylate histones", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10547965" ], "products": [ "species_10547971", "species_5566518" ], "modifiers": [ [ "species_10548037", "catalyst" ] ], "additional_components": [ "P62784", "WBGene00001875", "P90916", "WBGene00003036", "G5EBZ4", "WBGene00002637", "Q22516", "WBGene00000482", "G5ECR1", "WBGene00023409", "O61907", "WBGene00003025", "P90917", "WBGene00004312", "G5ECH0", "WBGene00001836", "Q09440", "WBGene00001835", "Q9NF71", "WBGene00013632", "O18691", "WBGene00013632", "Q18919", "WBGene00005006", "Q95Y41", "WBGene00022278", "A5JYT9", "WBGene00009508", "Q11107", "WBGene00003002" ] }, "reaction_10548187": { "compartment": "compartment_7660", "id": "reaction_10548187", "reactome": "R-CEL-3782655", "name": "HDAC10 deacetylates histone", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10547965" ], "products": [ "species_10547971", "species_5566518" ], "modifiers": [ [ "species_10548184", "catalyst" ] ], "additional_components": [ "P62784", "WBGene00001875", "WBGene00001838" ] }, "reaction_10520785": { "compartment": "compartment_17951", "id": "reaction_10520785", "reactome": "R-CEL-390284", "name": "propionyl-CoA + carnitine => propionylcarnitine + CoASH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_192314", "species_390294" ], "products": [ "species_193514", "species_390274" ], "modifiers": [ [ "species_10520782", "catalyst" ] ], "additional_components": [ "WBGene00007175" ] }, "reaction_10520754": { "compartment": "compartment_17951", "id": "reaction_10520754", "reactome": "R-CEL-389986", "name": "trans-2,3-dehydropristanoyl-CoA + H2O => 3-hydroxypristanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_141343", "species_389894" ], "products": [ "species_389982" ], "modifiers": [ [ "species_10513270", "catalyst" ] ], "additional_components": [ "Q19058", "WBGene00017123" ] }, "reaction_10520739": { "compartment": "compartment_17951", "id": "reaction_10520739", "reactome": "R-CEL-389889", "name": "ACOX2:FAD, ACOXL:FAD oxidise (2S)-pristanoyl-CoA to trans-2,3-dehydropristanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113535", "species_389893" ], "products": [ "species_113575", "species_389894" ], "modifiers": [ [ "species_10513307", "catalyst" ] ], "additional_components": [ "species_113596", "P34355", "WBGene00008167", "O62138", "WBGene00008566", "Q93839", "WBGene00010336", "O62139", "WBGene00008567", "O62140", "WBGene00008564", "O62137", "WBGene00008565" ] }, "reaction_10520787": { "compartment": "compartment_17951", "id": "reaction_10520787", "reactome": "R-CEL-390291", "name": "acetyl-CoA + carnitine => acetylcarnitine + CoASH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_353123", "species_390294" ], "products": [ "species_390287", "species_193514" ], "modifiers": [ [ "species_10520782", "catalyst" ] ], "additional_components": [ "WBGene00007175" ] }, "reaction_10520756": { "compartment": "compartment_17951", "id": "reaction_10520756", "reactome": "R-CEL-389995", "name": "3-hydroxypristanoyl-CoA + NAD+ => 3-ketoxypristanoyl-CoA + NADH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_389982", "species_192307" ], "products": [ "species_193465", "species_389996", "species_192305" ], "modifiers": [ [ "species_10513270", "catalyst" ] ], "additional_components": [ "Q19058", "WBGene00017123" ] }, "reaction_10520790": { "compartment": "compartment_17951", "id": "reaction_10520790", "reactome": "R-CEL-390304", "name": "acetyl-CoA + H2O => acetate + CoASH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_141343", "species_353123" ], "products": [ "species_193514", "species_390305" ], "modifiers": [ [ "species_10513389", "catalyst" ] ], "additional_components": [ "WBGene00015887" ] }, "reaction_10520777": { "compartment": "compartment_17951", "id": "reaction_10520777", "reactome": "R-CEL-390281", "name": "4,8-dimethylnonanoyl-CoA + carnitine => 4,8-dimethylnonanoylcarnitine + CoASH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_390271", "species_390294" ], "products": [ "species_193514", "species_390290" ], "modifiers": [ [ "species_10520774", "catalyst" ] ], "additional_components": [ "WBGene00011850" ] }, "reaction_10520749": { "compartment": "compartment_17951", "id": "reaction_10520749", "reactome": "R-CEL-389891", "name": "(2S)-pristanoyl-CoA + O2 => trans-2,3-dehydropristanoyl-CoA + H2O2 (ACOX3)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113535", "species_389893" ], "products": [ "species_113575", "species_389894" ], "modifiers": [ [ "species_10520746", "catalyst" ] ], "additional_components": [ "species_113596", "Q20992", "WBGene00019060" ] }, "reaction_10520751": { "compartment": "compartment_17951", "id": "reaction_10520751", "reactome": "R-CEL-389897", "name": "Isomerization of (2R)-pristanoyl-CoA to (2S)-pristanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_389569" ], "products": [ "species_389893" ], "modifiers": [ [ "species_10513241", "catalyst" ] ], "additional_components": [ "WBGene00016034" ] }, "reaction_10513025": { "compartment": "compartment_70101", "id": "reaction_10513025", "reactome": "R-CEL-191323", "name": "HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191293", "species_76183" ], "products": [ "species_29356", "species_191374", "species_76194" ], "modifiers": [ [ "species_10513022", "catalyst" ] ], "additional_components": [ "WBGene00017769" ] }, "reaction_10513507": { "compartment": "compartment_70101", "id": "reaction_10513507", "reactome": "R-CEL-194642", "name": "4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_194735", "species_29360" ], "products": [ "species_70106", "species_113528", "species_194667", "species_73473" ], "modifiers": [ [ "species_10513504", "catalyst" ] ], "additional_components": [ "WBGene00012394" ] }, "reaction_10513509": { "compartment": "compartment_70101", "id": "reaction_10513509", "reactome": "R-CEL-194718", "name": "4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_194657", "species_29360" ], "products": [ "species_70106", "species_113528", "species_194661", "species_73473" ], "modifiers": [ [ "species_10513504", "catalyst" ] ], "additional_components": [ "WBGene00012394" ] }, "reaction_10513665": { "compartment": "compartment_70101", "id": "reaction_10513665", "reactome": "R-CEL-196402", "name": "Cholesta-5,7,24-trien-3beta-ol is reduced to desmosterol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_195655", "species_29364" ], "products": [ "species_29366", "species_196420" ], "modifiers": [ [ "species_10513662", "catalyst" ] ], "additional_components": [ "WBGene00007126" ] }, "reaction_10513673": { "compartment": "compartment_70101", "id": "reaction_10513673", "reactome": "R-CEL-196417", "name": "Reduction of desmosterol to cholesterol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_196420", "species_29364" ], "products": [ "species_193384", "species_29366" ], "modifiers": [ [ "species_10513670", "catalyst" ] ], "additional_components": [ "WBGene00018718" ] }, "reaction_10513065": { "compartment": "compartment_70101", "id": "reaction_10513065", "reactome": "R-CEL-191414", "name": "MVD decarboxylates MVA5PP to IPPP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_191403" ], "products": [ "species_29372", "species_29370", "species_113528", "species_191362" ], "modifiers": [ [ "species_10513062", "catalyst" ] ], "additional_components": [ "Q9U294", "WBGene00012984" ] }, "reaction_10513035": { "compartment": "compartment_70101", "id": "reaction_10513035", "reactome": "R-CEL-191352", "name": "HMGCR dimer reduces bHMG-CoA to MVA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191374", "species_70106", "species_29364" ], "products": [ "species_29366", "species_76194", "species_191424" ], "modifiers": [ [ "species_10513032", "catalyst" ] ], "additional_components": [ "Q19207", "WBGene00017268" ] }, "reaction_10563129": { "compartment": "compartment_12045", "id": "reaction_10563129", "reactome": "R-CEL-6807055", "name": "DHCR7 reduces 7-dehydroCHOL to CHOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_6807057", "species_29364" ], "products": [ "species_193384", "species_29366" ], "modifiers": [ [ "species_10513662", "catalyst" ] ], "additional_components": [ "WBGene00007126" ] }, "reaction_10563131": { "compartment": "compartment_12045", "id": "reaction_10563131", "reactome": "R-CEL-6807064", "name": "DHCR24 reduces ZYMOL to ZYMSTNL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_194691" ], "products": [ "species_6807048", "species_29366" ], "modifiers": [ [ "species_10513670", "catalyst" ] ], "additional_components": [ "WBGene00018718" ] }, "reaction_10513073": { "compartment": "compartment_70101", "id": "reaction_10513073", "reactome": "R-CEL-191422", "name": "Mevalonate-5-phosphate is further phosphorylated.", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_191296" ], "products": [ "species_29370", "species_191403" ], "modifiers": [ [ "species_10513070", "catalyst" ] ], "additional_components": [ "WBGene00009335" ] }, "reaction_10513045": { "compartment": "compartment_70101", "id": "reaction_10513045", "reactome": "R-CEL-191380", "name": "Mevalonate is phosphorylated to mevalonate-5-phosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_191424" ], "products": [ "species_29370", "species_191296" ], "modifiers": [ [ "species_10513042", "catalyst" ] ], "additional_components": [ "Q65XX9", "WBGene00021534" ] }, "reaction_10569175": { "compartment": "compartment_70101", "id": "reaction_10569175", "reactome": "R-CEL-8952137", "name": "Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_191265" ], "products": [ "species_8952135", "species_29372" ], "modifiers": [ [ "species_10569172", "catalyst" ] ], "additional_components": [ "WBGene00020486" ] }, "reaction_10513017": { "compartment": "compartment_70101", "id": "reaction_10513017", "reactome": "R-CEL-191303", "name": "Another isopentenyl pyrophosphate is added to geranyl pyrophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191409", "species_191362" ], "products": [ "species_111294", "species_191385" ], "modifiers": [ [ "species_10513014", "catalyst" ] ], "additional_components": [ "O62336", "WBGene00011058", "species_114632" ] }, "reaction_10551001": { "compartment": "compartment_17957", "id": "reaction_10551001", "reactome": "R-CEL-5250531", "name": "ARV1 transports CHOL from ER membrane to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193384" ], "products": [ "species_171095" ], "modifiers": [ [ "species_10550998", "catalyst" ] ], "additional_components": [ "WBGene00011040" ] }, "reaction_10513020": { "compartment": "compartment_70101", "id": "reaction_10513020", "reactome": "R-CEL-191322", "name": "Addition of isopentenyl pyrophosphate to DMAPP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191324", "species_191362" ], "products": [ "species_111294", "species_191409" ], "modifiers": [ [ "species_10513014", "catalyst" ] ], "additional_components": [ "O62336", "WBGene00011058", "species_114632" ] }, "reaction_10513055": { "compartment": "compartment_70101", "id": "reaction_10513055", "reactome": "R-CEL-191382", "name": "Isopentenyl pyrophosphate rearranges to dimethylallyl pyrophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191362" ], "products": [ "species_191324" ], "modifiers": [ [ "species_10513052", "catalyst" ] ], "additional_components": [ "species_114632", "G5EFQ1", "WBGene00019460" ] }, "reaction_10546084": { "compartment": "compartment_7660", "id": "reaction_10546084", "reactome": "R-CEL-2993780", "name": "Transfer of SUMO1 from E1 to UBE2I (UBC9)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546073", "species_10546009" ], "products": [ "species_10546081", "species_10545999" ], "modifiers": [ [ "species_10545999", "catalyst" ] ], "additional_components": [ "WBGene00006706", "Q9NAN1", "WBGene00006700", "P55853", "WBGene00004888", "Q17820", "WBGene00000142", "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "Q17820", "WBGene00000142", "Q9NAN1", "WBGene00006700", "Q17820", "WBGene00000142", "Q9NAN1", "WBGene00006700" ] }, "reaction_10563041": { "compartment": "compartment_984", "id": "reaction_10563041", "reactome": "R-CEL-6804099", "name": "HMGB1 binds LTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10563037", "species_181015" ], "products": [ "species_10563039" ], "modifiers": [], "additional_components": [ "G5EFV4", "WBGene00001971", "Q09390", "WBGene00001972", "species_181015", "G5EFV4", "WBGene00001971", "Q09390", "WBGene00001972" ] }, "reaction_10563090": { "compartment": "compartment_984", "id": "reaction_10563090", "reactome": "R-CEL-6805981", "name": "HMGB1 release from cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10517878" ], "products": [ "species_10563037" ], "modifiers": [], "additional_components": [ "Q09390", "WBGene00001972", "G5EFV4", "WBGene00001971", "G5EFV4", "WBGene00001971", "Q09390", "WBGene00001972" ] }, "reaction_10563045": { "compartment": "compartment_984", "id": "reaction_10563045", "reactome": "R-CEL-6804100", "name": "HMGB1 binds LPS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10563037", "species_166005" ], "products": [ "species_10563043" ], "modifiers": [], "additional_components": [ "G5EFV4", "WBGene00001971", "Q09390", "WBGene00001972", "species_166005", "G5EFV4", "WBGene00001971", "Q09390", "WBGene00001972" ] }, "reaction_10566733": { "compartment": "compartment_984", "id": "reaction_10566733", "reactome": "R-CEL-8869683", "name": "oxPL binds LBP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10510717", "species_2186967" ], "products": [ "species_10566731" ], "modifiers": [], "additional_components": [ "Q20380", "WBGene00022627", "Q17654", "WBGene00022627", "H9G2Z8", "WBGene00022627", "Q23365", "WBGene00022627", "Q17738", "WBGene00022627", "O17768", "WBGene00022627", "Q93796", "WBGene00003812", "Q18869", "WBGene00022627", "Q10011", "WBGene00020563", "A8WFJ7", "WBGene00022627", "species_2186967", "Q20380", "WBGene00022627", "Q17654", "WBGene00022627", "H9G2Z8", "WBGene00022627", "Q23365", "WBGene00022627", "Q17738", "WBGene00022627", "O17768", "WBGene00022627", "Q93796", "WBGene00003812", "Q18869", "WBGene00022627", "Q10011", "WBGene00020563", "A8WFJ7", "WBGene00022627" ] }, "reaction_10510723": { "compartment": "compartment_984", "id": "reaction_10510723", "reactome": "R-CEL-166015", "name": "Association of LBP with LPS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10510717", "species_166005" ], "products": [ "species_10510719" ], "modifiers": [ [ "species_10510721", "inhibitor" ] ], "additional_components": [ "Q20380", "WBGene00022627", "Q17654", "WBGene00022627", "H9G2Z8", "WBGene00022627", "Q23365", "WBGene00022627", "Q17738", "WBGene00022627", "O17768", "WBGene00022627", "Q93796", "WBGene00003812", "Q18869", "WBGene00022627", "Q10011", "WBGene00020563", "A8WFJ7", "WBGene00022627", "species_166005", "Q20380", "WBGene00022627", "Q17654", "WBGene00022627", "H9G2Z8", "WBGene00022627", "Q23365", "WBGene00022627", "Q17738", "WBGene00022627", "O17768", "WBGene00022627", "Q93796", "WBGene00003812", "Q18869", "WBGene00022627", "Q10011", "WBGene00020563", "A8WFJ7", "WBGene00022627", "WBGene00020563" ] }, "reaction_10569028": { "compartment": "compartment_70101", "id": "reaction_10569028", "reactome": "R-CEL-8950778", "name": "p-Y693-STAT4 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10568972" ], "products": [ "species_10568974" ], "modifiers": [], "additional_components": [ "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111" ] }, "reaction_10568984": { "compartment": "compartment_70101", "id": "reaction_10568984", "reactome": "R-CEL-8950181", "name": "Y693-STAT4 dimer translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10568974" ], "products": [ "species_10568982" ], "modifiers": [], "additional_components": [ "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111" ] }, "reaction_10569026": { "compartment": "compartment_876", "id": "reaction_10569026", "reactome": "R-CEL-8950766", "name": "IL27RA dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10569022" ], "products": [ "species_10569024" ], "modifiers": [], "additional_components": [ "WBGene00002915", "Q9UB28", "WBGene00002915" ] }, "reaction_10569032": { "compartment": "compartment_70101", "id": "reaction_10569032", "reactome": "R-CEL-8950782", "name": "p-STAT1 binds p-STAT3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10531883", "species_10528453" ], "products": [ "species_10531889" ], "modifiers": [], "additional_components": [ "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111" ] }, "reaction_10569020": { "compartment": "compartment_70101", "id": "reaction_10569020", "reactome": "R-CEL-8950733", "name": "p-Y701-STAT1:p-Y705-STAT3 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10531889" ], "products": [ "species_10531901" ], "modifiers": [], "additional_components": [ "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111" ] }, "reaction_10568990": { "compartment": "compartment_17957", "id": "reaction_10568990", "reactome": "R-CEL-8950387", "name": "CANX binds EBI3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10568986", "species_10527249" ], "products": [ "species_10568988" ], "modifiers": [], "additional_components": [ "WBGene00002915", "WBGene00000567", "P34652", "WBGene00000567", "Q9UB28", "WBGene00002915" ] }, "reaction_10569012": { "compartment": "compartment_70101", "id": "reaction_10569012", "reactome": "R-CEL-8950522", "name": "p-STAT1:p-STAT4 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10569008" ], "products": [ "species_10569010" ], "modifiers": [], "additional_components": [ "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111" ] }, "reaction_10521955": { "compartment": "compartment_70101", "id": "reaction_10521955", "reactome": "R-CEL-419049", "name": "ROCK activation by RHO", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10521949", "species_10509488" ], "products": [ "species_10521951" ], "modifiers": [ [ "species_10521953", "inhibitor" ] ], "additional_components": [ "P92199", "WBGene00002694", "Q21025", "WBGene00019087", "Q9XVH4", "WBGene00019087", "Q22038", "WBGene00004357", "species_29438", "Q22038", "WBGene00004357", "species_29438", "P92199", "WBGene00002694", "Q21025", "WBGene00019087", "Q9XVH4", "WBGene00019087", "P92199", "WBGene00002694", "Q21025", "WBGene00019087", "Q9XVH4", "WBGene00019087" ] }, "reaction_10573094": { "compartment": "compartment_70101", "id": "reaction_10573094", "reactome": "R-CEL-9680443", "name": "ROCK1,2 bind ROCKi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9686558", "species_10521949" ], "products": [ "species_10521953" ], "modifiers": [], "additional_components": [ "P92199", "WBGene00002694", "Q21025", "WBGene00019087", "Q9XVH4", "WBGene00019087", "P92199", "WBGene00002694", "Q21025", "WBGene00019087", "Q9XVH4", "WBGene00019087" ] }, "reaction_10514868": { "compartment": "compartment_70101", "id": "reaction_10514868", "reactome": "R-CEL-201608", "name": "Caspase-mediated cleavage of alpha adducin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10514862" ], "products": [ "species_10514866", "species_10514864" ], "modifiers": [ [ "species_10509422", "catalyst" ] ], "additional_components": [ "WBGene00000073", "WBGene00000073", "WBGene00000073", "P42573", "WBGene00000417" ] }, "reaction_10515348": { "compartment": "compartment_70101", "id": "reaction_10515348", "reactome": "R-CEL-202966", "name": "Caspase mediated cleavage of HIP-55", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10515342" ], "products": [ "species_10515346", "species_10515344" ], "modifiers": [ [ "species_10509422", "catalyst" ] ], "additional_components": [ "WBGene00010664", "WBGene00010664", "WBGene00010664", "P42573", "WBGene00000417" ] }, "reaction_10515359": { "compartment": "compartment_70101", "id": "reaction_10515359", "reactome": "R-CEL-202967", "name": "Caspase mediated cleavage of alpha-II-Fodrin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10515353" ], "products": [ "species_10515357", "species_10515355" ], "modifiers": [ [ "species_10509422", "catalyst" ] ], "additional_components": [ "WBGene00004951", "WBGene00004951", "WBGene00004951", "P42573", "WBGene00000417" ] }, "reaction_10572369": { "compartment": "compartment_161320", "id": "reaction_10572369", "reactome": "R-CEL-9638076", "name": "HEXB cleaves the terminal GalNAc from small HA fragments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2162223", "species_1605715" ], "products": [ "species_1678743", "species_2162224" ], "modifiers": [ [ "species_10536355", "catalyst" ] ], "additional_components": [ "Q22492", "WBGene00020509" ] }, "reaction_10543041": { "compartment": "compartment_161320", "id": "reaction_10543041", "reactome": "R-CEL-2162225", "name": "HEXA cleaves the terminal GalNAc from small HA fragments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2162223", "species_1605715" ], "products": [ "species_1678743", "species_2162224" ], "modifiers": [ [ "species_10536342", "catalyst" ] ], "additional_components": [ "Q22492", "WBGene00020509" ] }, "reaction_10543043": { "compartment": "compartment_161320", "id": "reaction_10543043", "reactome": "R-CEL-2162226", "name": "GUSB tetramer hydrolyses GlcA-1,3-GlcNAc", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2162224" ], "products": [ "species_1678743", "species_1678868" ], "modifiers": [ [ "species_10537432", "catalyst" ] ], "additional_components": [ "Q95Q32", "WBGene00013693" ] }, "reaction_10543045": { "compartment": "compartment_161320", "id": "reaction_10543045", "reactome": "R-CEL-2162227", "name": "GUSB tetramer hydrolyses (HA)2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2160866" ], "products": [ "species_2162223", "species_1678868" ], "modifiers": [ [ "species_10537432", "catalyst" ] ], "additional_components": [ "species_2162224", "Q95Q32", "WBGene00013693" ] }, "reaction_10542936": { "compartment": "compartment_161320", "id": "reaction_10542936", "reactome": "R-CEL-2160874", "name": "HYAL1 hydrolyses (HA)50", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2160864" ], "products": [ "species_2160866" ], "modifiers": [ [ "species_10537452", "catalyst" ] ], "additional_components": [ "species_2162224", "species_2162224", "WBGene00011923" ] }, "reaction_10542957": { "compartment": "compartment_876", "id": "reaction_10542957", "reactome": "R-CEL-2160892", "name": "Hyaluronidase 2 (HYAL2) hydrolyses HA into 20kDa fragments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10542954" ], "products": [ "species_2160894", "species_10542954" ], "modifiers": [ [ "species_10542954", "catalyst" ] ], "additional_components": [ "species_74016", "Q23643", "WBGene00014109", "P35449", "WBGene00003736", "G5EDU2", "WBGene00003732", "Q8T5S1", "WBGene00003730", "H2L039", "WBGene00003734", "O16452", "WBGene00003731", "species_2162224", "G5ECE8", "WBGene00011923", "species_2162224", "species_74016", "Q23643", "WBGene00014109", "P35449", "WBGene00003736", "G5EDU2", "WBGene00003732", "Q8T5S1", "WBGene00003730", "H2L039", "WBGene00003734", "O16452", "WBGene00003731", "species_2162224", "G5ECE8", "WBGene00011923", "species_74016", "Q23643", "WBGene00014109", "P35449", "WBGene00003736", "G5EDU2", "WBGene00003732", "Q8T5S1", "WBGene00003730", "H2L039", "WBGene00003734", "O16452", "WBGene00003731", "species_2162224", "G5ECE8", "WBGene00011923" ] }, "reaction_10502580": { "compartment": "compartment_7660", "id": "reaction_10502580", "reactome": "R-CEL-68950", "name": "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30187", "species_30185", "species_10502151", "species_29892", "species_29604" ], "products": [ "species_10502577" ], "modifiers": [ [ "species_10502123", "catalyst" ] ], "additional_components": [ "C7IVS4", "WBGene00012936", "P34471", "WBGene00004180", "O02334", "WBGene00004181", "Q21625", "WBGene00001002", "C7IVS4", "WBGene00012936", "P34471", "WBGene00004180", "O02334", "WBGene00004181", "Q21625", "WBGene00001002", "C7IVS4", "WBGene00012936", "P34471", "WBGene00004180", "O02334", "WBGene00004181", "Q21625", "WBGene00001002" ] }, "reaction_10502154": { "compartment": "compartment_7660", "id": "reaction_10502154", "reactome": "R-CEL-68913", "name": "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502149", "species_30595" ], "products": [ "species_10502151", "species_10502145" ], "modifiers": [ [ "species_10502149", "catalyst" ] ], "additional_components": [ "O62218", "WBGene00009368", "Q19196", "WBGene00017237", "Q22798", "WBGene00020823", "Q9NAC5", "WBGene00013150", "C7IVS4", "WBGene00012936", "P34471", "WBGene00004180", "O02334", "WBGene00004181", "Q21625", "WBGene00001002", "species_110614", "species_29358", "species_29494", "species_29438", "C7IVS4", "WBGene00012936", "P34471", "WBGene00004180", "O02334", "WBGene00004181", "Q21625", "WBGene00001002", "O62218", "WBGene00009368", "Q19196", "WBGene00017237", "Q22798", "WBGene00020823", "Q9NAC5", "WBGene00013150", "O62218", "WBGene00009368", "Q19196", "WBGene00017237", "Q22798", "WBGene00020823", "Q9NAC5", "WBGene00013150", "C7IVS4", "WBGene00012936", "P34471", "WBGene00004180", "O02334", "WBGene00004181", "Q21625", "WBGene00001002" ] }, "reaction_10502343": { "compartment": "compartment_7660", "id": "reaction_10502343", "reactome": "R-CEL-68946", "name": "Phosphorylated Orc1 is ubiquitinated while still associated with chromatin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502318", "species_10502250" ], "products": [ "species_10502321" ], "modifiers": [ [ "species_10502340", "catalyst" ] ], "additional_components": [ "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "WBGene00012650", "WBGene00012650", "Q23457", "WBGene00004320", "G5ECU1", "WBGene00004807", "Q17389", "WBGene00000836" ] }, "reaction_10502281": { "compartment": "compartment_7660", "id": "reaction_10502281", "reactome": "R-CEL-68944", "name": "Orc1 is phosphorylated by cyclin A/CDK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10502240" ], "products": [ "species_113582", "species_10502252", "species_10502250" ], "modifiers": [ [ "species_10502278", "catalyst" ] ], "additional_components": [ "O16297", "WBGene00003159", "Q95XQ8", "WBGene00003156", "Q9XXI9", "WBGene00003154", "Q21902", "WBGene00003157", "P34647", "WBGene00003158", "Q9XVR7", "WBGene00003155", "Q9XX16", "WBGene00012651", "Q23249", "WBGene00013857", "Q9XX17", "WBGene00012650", "Q21037", "WBGene00003882", "P91155", "WBGene00000382", "Q86S68", "WBGene00000413", "Q9XX16", "WBGene00012651", "Q86S68", "WBGene00000413", "P91155", "WBGene00000382", "Q23249", "WBGene00013857", "O16297", "WBGene00003159", "Q95XQ8", "WBGene00003156", "Q9XXI9", "WBGene00003154", "Q21902", "WBGene00003157", "P34647", "WBGene00003158", "Q9XVR7", "WBGene00003155", "Q21037", "WBGene00003882", "WBGene00012650", "O61847", "WBGene00019362" ] }, "reaction_10502347": { "compartment": "compartment_7660", "id": "reaction_10502347", "reactome": "R-CEL-68947", "name": "Ubiquitinated Orc1 enters the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502321" ], "products": [ "species_10502345" ], "modifiers": [], "additional_components": [ "WBGene00012650", "WBGene00012650" ] }, "reaction_10502575": { "compartment": "compartment_70101", "id": "reaction_10502575", "reactome": "R-CEL-68948", "name": "Ubiquitinated Orc1 is degraded by the proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502345" ], "products": [ "species_10502375" ], "modifiers": [ [ "species_10502572", "catalyst" ] ], "additional_components": [ "WBGene00012650", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "P91477", "WBGene00003950", "Q95PZ7", "WBGene00013435", "Q18115", "WBGene00004459", "O62102", "WBGene00003948", "O17071", "WBGene00004504", "Q10920", "WBGene00016623", "P34286", "WBGene00003952", "Q9XTT9", "WBGene00004506", "Q23449", "WBGene00004468", "Q95005", "WBGene00003925", "P46502", "WBGene00004503", "O61792", "WBGene00004464", "O17586", "WBGene00003922", "O76371", "WBGene00004505", "Q20585", "WBGene00004463", "Q95008", "WBGene00003926", "Q18787", "WBGene00004501", "Q20058", "WBGene00009445", "Q9N599", "WBGene00003924", "O16368", "WBGene00004502", "O61742", "WBGene00004466", "Q09583", "WBGene00003928", "Q966I8", "WBGene00003947", "Q04908", "WBGene00004460", "Q9XUV0", "WBGene00003951", "Q27488", "WBGene00003923", "Q9GZH5", "WBGene00004458", "O44156", "WBGene00003927", "Q22253", "WBGene00004465", "O76577", "WBGene00004467", "P90868", "WBGene00003953", "Q19324", "WBGene00004461", "Q17971", "WBGene00007588", "Q23237", "WBGene00003949", "Q20938", "WBGene00004462" ] }, "reaction_10502611": { "compartment": "compartment_70101", "id": "reaction_10502611", "reactome": "R-CEL-69016", "name": "Ubiquitinated Cdc6 is degraded by the proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502609" ], "products": [ "species_10502375" ], "modifiers": [ [ "species_10502572", "catalyst" ] ], "additional_components": [ "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "P91155", "WBGene00000382", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "P91477", "WBGene00003950", "Q95PZ7", "WBGene00013435", "Q18115", "WBGene00004459", "O62102", "WBGene00003948", "O17071", "WBGene00004504", "Q10920", "WBGene00016623", "P34286", "WBGene00003952", "Q9XTT9", "WBGene00004506", "Q23449", "WBGene00004468", "Q95005", "WBGene00003925", "P46502", "WBGene00004503", "O61792", "WBGene00004464", "O17586", "WBGene00003922", "O76371", "WBGene00004505", "Q20585", "WBGene00004463", "Q95008", "WBGene00003926", "Q18787", "WBGene00004501", "Q20058", "WBGene00009445", "Q9N599", "WBGene00003924", "O16368", "WBGene00004502", "O61742", "WBGene00004466", "Q09583", "WBGene00003928", "Q966I8", "WBGene00003947", "Q04908", "WBGene00004460", "Q9XUV0", "WBGene00003951", "Q27488", "WBGene00003923", "Q9GZH5", "WBGene00004458", "O44156", "WBGene00003927", "Q22253", "WBGene00004465", "O76577", "WBGene00004467", "P90868", "WBGene00003953", "Q19324", "WBGene00004461", "Q17971", "WBGene00007588", "Q23237", "WBGene00003949", "Q20938", "WBGene00004462" ] }, "reaction_10502601": { "compartment": "compartment_7660", "id": "reaction_10502601", "reactome": "R-CEL-69005", "name": "Cdc6 protein is phosphorylated by CDK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10502084" ], "products": [ "species_113582", "species_10502587" ], "modifiers": [ [ "species_10502598", "catalyst" ] ], "additional_components": [ "WBGene00000382", "WBGene00000382", "O01501", "WBGene00000871", "O61847", "WBGene00019362" ] }, "reaction_10502605": { "compartment": "compartment_7660", "id": "reaction_10502605", "reactome": "R-CEL-69006", "name": "Phosphorylated Cdc6 is exported from the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502587" ], "products": [ "species_10502603" ], "modifiers": [], "additional_components": [ "WBGene00000382", "WBGene00000382" ] }, "reaction_10502615": { "compartment": "compartment_7660", "id": "reaction_10502615", "reactome": "R-CEL-69019", "name": "Mcm4,6,7 trimer forms and associates with the replication fork", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502216" ], "products": [ "species_10502189", "species_10502199", "species_10502214", "species_10502613" ], "modifiers": [], "additional_components": [ "O16297", "WBGene00003159", "Q95XQ8", "WBGene00003156", "Q9XXI9", "WBGene00003154", "Q21902", "WBGene00003157", "P34647", "WBGene00003158", "Q9XVR7", "WBGene00003155", "WBGene00003155", "WBGene00003157", "WBGene00003154", "O16297", "WBGene00003159", "Q95XQ8", "WBGene00003156", "P34647", "WBGene00003158" ] }, "reaction_10512052": { "compartment": "compartment_7660", "id": "reaction_10512052", "reactome": "R-CEL-176956", "name": "Formation of GINS complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10512043", "species_10512038", "species_10512033", "species_10512048" ], "products": [ "species_10512050" ], "modifiers": [], "additional_components": [ "WBGene00022043", "WBGene00009287", "WBGene00011275", "WBGene00013768", "Q9U2W9", "WBGene00013768", "Q22019", "WBGene00011275", "O62193", "WBGene00009287", "Q9BL54", "WBGene00022043" ] }, "reaction_10502657": { "compartment": "compartment_7660", "id": "reaction_10502657", "reactome": "R-CEL-69063", "name": "Loading of PCNA - Sliding Clamp Formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10502653", "species_10502644" ], "products": [ "species_113582", "species_10502655" ], "modifiers": [], "additional_components": [ "O02115", "WBGene00003955", "C7IVS4", "WBGene00012936", "P34471", "WBGene00004180", "O02334", "WBGene00004181", "Q21625", "WBGene00001002", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "C7IVS4", "WBGene00012936", "P34471", "WBGene00004180", "O02334", "WBGene00004181", "Q21625", "WBGene00001002", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "O02115", "WBGene00003955" ] }, "reaction_10502661": { "compartment": "compartment_7660", "id": "reaction_10502661", "reactome": "R-CEL-69068", "name": "RFC dissociates after sliding clamp formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502655" ], "products": [ "species_10502659", "species_10502642" ], "modifiers": [], "additional_components": [ "C7IVS4", "WBGene00012936", "P34471", "WBGene00004180", "O02334", "WBGene00004181", "Q21625", "WBGene00001002", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "O02115", "WBGene00003955", "C7IVS4", "WBGene00012936", "P34471", "WBGene00004180", "O02334", "WBGene00004181", "Q21625", "WBGene00001002", "O02115", "WBGene00003955", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409" ] }, "reaction_10502646": { "compartment": "compartment_7660", "id": "reaction_10502646", "reactome": "R-CEL-69053", "name": "RFC binding displaces Pol Alpha", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502642", "species_10502577" ], "products": [ "species_10502644" ], "modifiers": [], "additional_components": [ "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "C7IVS4", "WBGene00012936", "P34471", "WBGene00004180", "O02334", "WBGene00004181", "Q21625", "WBGene00001002", "C7IVS4", "WBGene00012936", "P34471", "WBGene00004180", "O02334", "WBGene00004181", "Q21625", "WBGene00001002", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409" ] }, "reaction_10502684": { "compartment": "compartment_7660", "id": "reaction_10502684", "reactome": "R-CEL-69074", "name": "Formation of Processive Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502680", "species_10502659" ], "products": [ "species_10502682" ], "modifiers": [], "additional_components": [ "P90829", "WBGene00008645", "Q19366", "WBGene00008722", "Q21730", "WBGene00011016", "C7IVS4", "WBGene00012936", "P34471", "WBGene00004180", "O02334", "WBGene00004181", "Q21625", "WBGene00001002", "O02115", "WBGene00003955", "C7IVS4", "WBGene00012936", "P34471", "WBGene00004180", "O02334", "WBGene00004181", "Q21625", "WBGene00001002", "O02115", "WBGene00003955", "P90829", "WBGene00008645", "Q19366", "WBGene00008722", "Q21730", "WBGene00011016" ] }, "reaction_10502727": { "compartment": "compartment_7660", "id": "reaction_10502727", "reactome": "R-CEL-69152", "name": "Removal of remaining Flap", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502717" ], "products": [ "species_10502719" ], "modifiers": [ [ "species_10502724", "catalyst" ] ], "additional_components": [ "C7IVS4", "WBGene00012936", "P34471", "WBGene00004180", "O02334", "WBGene00004181", "Q21625", "WBGene00001002", "O02115", "WBGene00003955", "P90829", "WBGene00008645", "Q19366", "WBGene00008722", "Q21730", "WBGene00011016", "C7IVS4", "WBGene00012936", "P34471", "WBGene00004180", "O02334", "WBGene00004181", "Q21625", "WBGene00001002", "O02115", "WBGene00003955", "P90829", "WBGene00008645", "Q19366", "WBGene00008722", "Q21730", "WBGene00011016", "WBGene00000794" ] }, "reaction_10502715": { "compartment": "compartment_7660", "id": "reaction_10502715", "reactome": "R-CEL-69142", "name": "Recruitment of Dna2 endonuclease", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502711", "species_10502706" ], "products": [ "species_10502713" ], "modifiers": [], "additional_components": [ "WBGene00001016", "Q95Y97", "WBGene00019767", "C7IVS4", "WBGene00012936", "P34471", "WBGene00004180", "O02334", "WBGene00004181", "Q21625", "WBGene00001002", "O02115", "WBGene00003955", "P90829", "WBGene00008645", "Q19366", "WBGene00008722", "Q21730", "WBGene00011016", "Q95Y97", "WBGene00019767", "C7IVS4", "WBGene00012936", "P34471", "WBGene00004180", "O02334", "WBGene00004181", "Q21625", "WBGene00001002", "O02115", "WBGene00003955", "P90829", "WBGene00008645", "Q19366", "WBGene00008722", "Q21730", "WBGene00011016", "Q9U3F2", "WBGene00001016" ] }, "reaction_10502689": { "compartment": "compartment_7660", "id": "reaction_10502689", "reactome": "R-CEL-69116", "name": "Formation of Okazaki fragments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502682" ], "products": [ "species_10502686" ], "modifiers": [ [ "species_10502680", "catalyst" ] ], "additional_components": [ "C7IVS4", "WBGene00012936", "P34471", "WBGene00004180", "O02334", "WBGene00004181", "Q21625", "WBGene00001002", "O02115", "WBGene00003955", "P90829", "WBGene00008645", "Q19366", "WBGene00008722", "Q21730", "WBGene00011016", "C7IVS4", "WBGene00012936", "P34471", "WBGene00004180", "O02334", "WBGene00004181", "Q21625", "WBGene00001002", "O02115", "WBGene00003955", "P90829", "WBGene00008645", "Q19366", "WBGene00008722", "Q21730", "WBGene00011016", "P90829", "WBGene00008645", "Q19366", "WBGene00008722", "Q21730", "WBGene00011016" ] }, "reaction_10502693": { "compartment": "compartment_7660", "id": "reaction_10502693", "reactome": "R-CEL-69127", "name": "Formation of the Flap Intermediate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502686" ], "products": [ "species_10502691" ], "modifiers": [], "additional_components": [ "C7IVS4", "WBGene00012936", "P34471", "WBGene00004180", "O02334", "WBGene00004181", "Q21625", "WBGene00001002", "O02115", "WBGene00003955", "P90829", "WBGene00008645", "Q19366", "WBGene00008722", "Q21730", "WBGene00011016", "C7IVS4", "WBGene00012936", "P34471", "WBGene00004180", "O02334", "WBGene00004181", "Q21625", "WBGene00001002", "O02115", "WBGene00003955", "P90829", "WBGene00008645", "Q19366", "WBGene00008722", "Q21730", "WBGene00011016" ] }, "reaction_10502735": { "compartment": "compartment_7660", "id": "reaction_10502735", "reactome": "R-CEL-69173", "name": "Joining of adjacent Okazaki fragments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_68452" ], "products": [ "species_69172" ], "modifiers": [ [ "species_10502732", "catalyst" ] ], "additional_components": [ "WBGene00002985" ] }, "reaction_10544506": { "compartment": "compartment_7660", "id": "reaction_10544506", "reactome": "R-CEL-2468039", "name": "Acetylation of SMC3 subunit of chromosomal arm associated cohesin by ESCO1 or ESCO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113560", "species_10544486" ], "products": [ "species_2485002", "species_10544494" ], "modifiers": [ [ "species_10544503", "catalyst" ] ], "additional_components": [ "H2L0H5", "WBGene00019953", "B2FDA8", "WBGene00004873", "Q19325", "WBGene00004737", "Q9XUB3", "WBGene00004333", "Q19555", "WBGene00004738", "O01789", "WBGene00001860", "G5EC05", "WBGene00001352", "H2L0H5", "WBGene00019953", "Q19325", "WBGene00004737", "Q9XUB3", "WBGene00004333", "Q19555", "WBGene00004738", "B2FDA8", "WBGene00004873", "O01789", "WBGene00001860", "G5EC05", "WBGene00001352", "Q19206", "WBGene00017269" ] }, "reaction_10544558": { "compartment": "compartment_7660", "id": "reaction_10544558", "reactome": "R-CEL-2473152", "name": "Acetylation of SMC3 subunit of centromeric chromatin associated cohesin by ESCO1 or ESCO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10544554", "species_113560" ], "products": [ "species_2485002", "species_10544556" ], "modifiers": [ [ "species_10544503", "catalyst" ] ], "additional_components": [ "H2L0H5", "WBGene00019953", "B2FDA8", "WBGene00004873", "Q19325", "WBGene00004737", "Q9XUB3", "WBGene00004333", "Q19555", "WBGene00004738", "O01789", "WBGene00001860", "G5EC05", "WBGene00001352", "H2L0H5", "WBGene00019953", "Q19325", "WBGene00004737", "Q9XUB3", "WBGene00004333", "Q19555", "WBGene00004738", "B2FDA8", "WBGene00004873", "O01789", "WBGene00001860", "G5EC05", "WBGene00001352", "Q19206", "WBGene00017269" ] }, "reaction_10511601": { "compartment": "compartment_70101", "id": "reaction_10511601", "reactome": "R-CEL-174054", "name": "Formation of Cyclin A:Cdk2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10511204", "species_10502737" ], "products": [ "species_10511599" ], "modifiers": [], "additional_components": [ "WBGene00019362", "O61847", "WBGene00019362" ] }, "reaction_10513907": { "compartment": "compartment_70101", "id": "reaction_10513907", "reactome": "R-CEL-198613", "name": "AKT phosphorylates p21Cip1 and p27Kip1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10512493", "species_113592" ], "products": [ "species_29370", "species_10513904" ], "modifiers": [ [ "species_10513848", "catalyst" ] ], "additional_components": [ "WBGene00000517", "WBGene00000517", "Q9XTG7", "WBGene00000103", "G4S4W1", "WBGene00016980", "Q17941", "WBGene00000102" ] }, "reaction_10512676": { "compartment": "compartment_7660", "id": "reaction_10512676", "reactome": "R-CEL-187948", "name": "Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10511632" ], "products": [ "species_113582", "species_10511634" ], "modifiers": [ [ "species_10502278", "catalyst" ] ], "additional_components": [ "WBGene00001510", "WBGene00001510", "O61847", "WBGene00019362" ] }, "reaction_10512678": { "compartment": "compartment_7660", "id": "reaction_10512678", "reactome": "R-CEL-187949", "name": "CAK-mediated phosphorylation of Cyclin A:Cdk2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10511613" ], "products": [ "species_113582", "species_10502278" ], "modifiers": [ [ "species_10506279", "catalyst" ] ], "additional_components": [ "O61847", "WBGene00019362", "O61847", "WBGene00019362", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408" ] }, "reaction_10511719": { "compartment": "compartment_13231", "id": "reaction_10511719", "reactome": "R-CEL-174273", "name": "Translocation of Cyclin A:Cdk2 complexes to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10511599" ], "products": [ "species_10511613" ], "modifiers": [], "additional_components": [ "O61847", "WBGene00019362", "O61847", "WBGene00019362" ] }, "reaction_10512609": { "compartment": "compartment_7660", "id": "reaction_10512609", "reactome": "R-CEL-187574", "name": "Degradation of ubiquitinated p27/p21 by the 26S proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10512520" ], "products": [ "species_10502318", "species_10502598", "species_10512514" ], "modifiers": [ [ "species_10512606", "catalyst" ] ], "additional_components": [ "G5ECU1", "WBGene00004807", "Q17389", "WBGene00000836", "Q17868", "WBGene00001051", "G5EEJ2", "WBGene00000517", "O01501", "WBGene00000871", "O61847", "WBGene00019362", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "O01501", "WBGene00000871", "O61847", "WBGene00019362", "G5ECU1", "WBGene00004807", "Q17389", "WBGene00000836", "Q17868", "WBGene00001051", "Q23237", "WBGene00003949", "P90868", "WBGene00003953", "Q9XUV0", "WBGene00003951", "Q966I8", "WBGene00003947", "O62102", "WBGene00003948", "O16368", "WBGene00004502", "Q18787", "WBGene00004501", "O76371", "WBGene00004505", "P46502", "WBGene00004503", "Q9XTT9", "WBGene00004506", "O17071", "WBGene00004504", "Q18115", "WBGene00004459", "Q20938", "WBGene00004462", "Q19324", "WBGene00004461", "Q22253", "WBGene00004465", "Q9GZH5", "WBGene00004458", "Q04908", "WBGene00004460", "O61742", "WBGene00004466", "O76577", "WBGene00004467", "Q20058", "WBGene00009445", "O44156", "WBGene00003927", "Q20585", "WBGene00004463", "Q27488", "WBGene00003923", "O61792", "WBGene00004464", "Q09583", "WBGene00003928", "Q23449", "WBGene00004468", "Q9N599", "WBGene00003924", "Q10920", "WBGene00016623", "Q95008", "WBGene00003926", "Q95PZ7", "WBGene00013435", "O17586", "WBGene00003922", "Q95005", "WBGene00003925", "P34286", "WBGene00003952", "P91477", "WBGene00003950" ] }, "reaction_10512612": { "compartment": "compartment_7660", "id": "reaction_10512612", "reactome": "R-CEL-187575", "name": "Ubiquitination of phospho-p27/p21", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502318", "species_10512516" ], "products": [ "species_10512520" ], "modifiers": [ [ "species_10512516", "catalyst" ] ], "additional_components": [ "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "G5ECU1", "WBGene00004807", "Q17389", "WBGene00000836", "Q17868", "WBGene00001051", "G5EEJ2", "WBGene00000517", "O01501", "WBGene00000871", "O61847", "WBGene00019362", "G5ECU1", "WBGene00004807", "Q17389", "WBGene00000836", "Q17868", "WBGene00001051", "G5EEJ2", "WBGene00000517", "O01501", "WBGene00000871", "O61847", "WBGene00019362", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "G5ECU1", "WBGene00004807", "Q17389", "WBGene00000836", "Q17868", "WBGene00001051", "G5EEJ2", "WBGene00000517", "O01501", "WBGene00000871", "O61847", "WBGene00019362" ] }, "reaction_10512518": { "compartment": "compartment_7660", "id": "reaction_10512518", "reactome": "R-CEL-187552", "name": "Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10512502", "species_10512514" ], "products": [ "species_10512516" ], "modifiers": [], "additional_components": [ "G5EEJ2", "WBGene00000517", "O01501", "WBGene00000871", "O61847", "WBGene00019362", "G5ECU1", "WBGene00004807", "Q17389", "WBGene00000836", "Q17868", "WBGene00001051", "G5ECU1", "WBGene00004807", "Q17389", "WBGene00000836", "Q17868", "WBGene00001051", "G5EEJ2", "WBGene00000517", "O01501", "WBGene00000871", "O61847", "WBGene00019362" ] }, "reaction_10512505": { "compartment": "compartment_7660", "id": "reaction_10512505", "reactome": "R-CEL-187520", "name": "Cyclin E/A:Cdk2-mediated phosphorylation of p27/p21", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10512497" ], "products": [ "species_113582", "species_10512502" ], "modifiers": [ [ "species_10512497", "catalyst" ] ], "additional_components": [ "O01501", "WBGene00000871", "O61847", "WBGene00019362", "G5EEJ2", "WBGene00000517", "G5EEJ2", "WBGene00000517", "O01501", "WBGene00000871", "O61847", "WBGene00019362", "O01501", "WBGene00000871", "O61847", "WBGene00019362", "G5EEJ2", "WBGene00000517" ] }, "reaction_10512668": { "compartment": "compartment_7660", "id": "reaction_10512668", "reactome": "R-CEL-187916", "name": "Cyclin A:Cdk2 mediated phosphorylation of p27/p21", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10512663" ], "products": [ "species_113582", "species_10512665" ], "modifiers": [ [ "species_10512663", "catalyst" ] ], "additional_components": [ "O61847", "WBGene00019362", "G5EEJ2", "WBGene00000517", "G5EEJ2", "WBGene00000517", "O61847", "WBGene00019362", "O61847", "WBGene00019362", "G5EEJ2", "WBGene00000517" ] }, "reaction_10512495": { "compartment": "compartment_13231", "id": "reaction_10512495", "reactome": "R-CEL-187506", "name": "Translocation of p27 to the nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10512493" ], "products": [ "species_10502767" ], "modifiers": [], "additional_components": [ "WBGene00000517", "WBGene00000517" ] }, "reaction_10511615": { "compartment": "compartment_7660", "id": "reaction_10511615", "reactome": "R-CEL-174110", "name": "Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10511611" ], "products": [ "species_113550", "species_10511613" ], "modifiers": [ [ "species_10502759", "catalyst" ] ], "additional_components": [ "O61847", "WBGene00019362", "O61847", "WBGene00019362", "WBGene00000389" ] }, "reaction_10511365": { "compartment": "compartment_876", "id": "reaction_10511365", "reactome": "R-CEL-170686", "name": "Adenylate cyclase increases the GTPase activity of Gi alpha", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10511333" ], "products": [ "species_29372", "species_10511351" ], "modifiers": [ [ "species_10511333", "catalyst" ] ], "additional_components": [ "Q7KPV0", "WBGene00001745", "V6CLB7", "WBGene00020997", "species_29438", "species_114632", "Q19523", "WBGene00000068", "O16880", "WBGene00000069", "G5EE33", "WBGene00000070", "Q966F9", "WBGene00000071", "O76584", "WBGene00001673", "Q9BIG5", "WBGene00001666", "Q21917", "WBGene00001669", "P91907", "WBGene00001677", "Q93743", "WBGene00001668", "Q20907", "WBGene00001670", "Q9BIG2", "WBGene00001676", "Q20910", "WBGene00001671", "species_114632", "Q19523", "WBGene00000068", "O16880", "WBGene00000069", "G5EE33", "WBGene00000070", "Q966F9", "WBGene00000071", "species_29420", "O76584", "WBGene00001673", "Q9BIG5", "WBGene00001666", "Q21917", "WBGene00001669", "P91907", "WBGene00001677", "Q93743", "WBGene00001668", "Q20907", "WBGene00001670", "Q9BIG2", "WBGene00001676", "Q20910", "WBGene00001671", "Q7KPV0", "WBGene00001745", "V6CLB7", "WBGene00020997", "Q7KPV0", "WBGene00001745", "V6CLB7", "WBGene00020997", "species_29438", "species_114632", "Q19523", "WBGene00000068", "O16880", "WBGene00000069", "G5EE33", "WBGene00000070", "Q966F9", "WBGene00000071", "O76584", "WBGene00001673", "Q9BIG5", "WBGene00001666", "Q21917", "WBGene00001669", "P91907", "WBGene00001677", "Q93743", "WBGene00001668", "Q20907", "WBGene00001670", "Q9BIG2", "WBGene00001676", "Q20910", "WBGene00001671" ] }, "reaction_10511353": { "compartment": "compartment_876", "id": "reaction_10511353", "reactome": "R-CEL-170674", "name": "Dissociation of the Gi alpha:G olf complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10511351" ], "products": [ "species_10511335", "species_10511349", "species_10508992" ], "modifiers": [], "additional_components": [ "species_114632", "Q19523", "WBGene00000068", "O16880", "WBGene00000069", "G5EE33", "WBGene00000070", "Q966F9", "WBGene00000071", "species_29420", "O76584", "WBGene00001673", "Q9BIG5", "WBGene00001666", "Q21917", "WBGene00001669", "P91907", "WBGene00001677", "Q93743", "WBGene00001668", "Q20907", "WBGene00001670", "Q9BIG2", "WBGene00001676", "Q20910", "WBGene00001671", "Q7KPV0", "WBGene00001745", "V6CLB7", "WBGene00020997", "Q7KPV0", "WBGene00001745", "V6CLB7", "WBGene00020997", "species_29420", "species_29420", "O76584", "WBGene00001673", "Q9BIG5", "WBGene00001666", "Q21917", "WBGene00001669", "P91907", "WBGene00001677", "Q93743", "WBGene00001668", "Q20907", "WBGene00001670", "Q9BIG2", "WBGene00001676", "Q20910", "WBGene00001671", "species_114632", "Q19523", "WBGene00000068", "O16880", "WBGene00000069", "G5EE33", "WBGene00000070", "Q966F9", "WBGene00000071" ] }, "reaction_10511340": { "compartment": "compartment_876", "id": "reaction_10511340", "reactome": "R-CEL-170666", "name": "Adenylate cyclase increases the GTPase activity of G alpha-olf", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10511333" ], "products": [ "species_29372", "species_10511337" ], "modifiers": [ [ "species_10511333", "catalyst" ] ], "additional_components": [ "Q7KPV0", "WBGene00001745", "V6CLB7", "WBGene00020997", "species_29438", "species_114632", "Q19523", "WBGene00000068", "O16880", "WBGene00000069", "G5EE33", "WBGene00000070", "Q966F9", "WBGene00000071", "O76584", "WBGene00001673", "Q9BIG5", "WBGene00001666", "Q21917", "WBGene00001669", "P91907", "WBGene00001677", "Q93743", "WBGene00001668", "Q20907", "WBGene00001670", "Q9BIG2", "WBGene00001676", "Q20910", "WBGene00001671", "species_114632", "Q19523", "WBGene00000068", "O16880", "WBGene00000069", "G5EE33", "WBGene00000070", "Q966F9", "WBGene00000071", "species_29438", "O76584", "WBGene00001673", "Q9BIG5", "WBGene00001666", "Q21917", "WBGene00001669", "P91907", "WBGene00001677", "Q93743", "WBGene00001668", "Q20907", "WBGene00001670", "Q9BIG2", "WBGene00001676", "Q20910", "WBGene00001671", "Q7KPV0", "WBGene00001745", "V6CLB7", "WBGene00020997", "species_29420", "Q7KPV0", "WBGene00001745", "V6CLB7", "WBGene00020997", "species_29438", "species_114632", "Q19523", "WBGene00000068", "O16880", "WBGene00000069", "G5EE33", "WBGene00000070", "Q966F9", "WBGene00000071", "O76584", "WBGene00001673", "Q9BIG5", "WBGene00001666", "Q21917", "WBGene00001669", "P91907", "WBGene00001677", "Q93743", "WBGene00001668", "Q20907", "WBGene00001670", "Q9BIG2", "WBGene00001676", "Q20910", "WBGene00001671" ] }, "reaction_10511342": { "compartment": "compartment_876", "id": "reaction_10511342", "reactome": "R-CEL-170671", "name": "G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10511331", "species_10511283" ], "products": [ "species_10511333" ], "modifiers": [], "additional_components": [ "species_114632", "Q19523", "WBGene00000068", "O16880", "WBGene00000069", "G5EE33", "WBGene00000070", "Q966F9", "WBGene00000071", "species_29438", "O76584", "WBGene00001673", "Q9BIG5", "WBGene00001666", "Q21917", "WBGene00001669", "P91907", "WBGene00001677", "Q93743", "WBGene00001668", "Q20907", "WBGene00001670", "Q9BIG2", "WBGene00001676", "Q20910", "WBGene00001671", "Q7KPV0", "WBGene00001745", "V6CLB7", "WBGene00020997", "species_29438", "Q7KPV0", "WBGene00001745", "V6CLB7", "WBGene00020997", "species_29438", "species_114632", "Q19523", "WBGene00000068", "O16880", "WBGene00000069", "G5EE33", "WBGene00000070", "Q966F9", "WBGene00000071", "O76584", "WBGene00001673", "Q9BIG5", "WBGene00001666", "Q21917", "WBGene00001669", "P91907", "WBGene00001677", "Q93743", "WBGene00001668", "Q20907", "WBGene00001670", "Q9BIG2", "WBGene00001676", "Q20910", "WBGene00001671" ] }, "reaction_10511360": { "compartment": "compartment_876", "id": "reaction_10511360", "reactome": "R-CEL-170677", "name": "The G alpha-olf:GDP:Adenylate cyclase complex dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10511358" ], "products": [ "species_10511335", "species_10508992" ], "modifiers": [], "additional_components": [ "species_114632", "Q19523", "WBGene00000068", "O16880", "WBGene00000069", "G5EE33", "WBGene00000070", "Q966F9", "WBGene00000071", "Q7KPV0", "WBGene00001745", "V6CLB7", "WBGene00020997", "species_29420", "Q7KPV0", "WBGene00001745", "V6CLB7", "WBGene00020997", "species_29420", "species_114632", "Q19523", "WBGene00000068", "O16880", "WBGene00000069", "G5EE33", "WBGene00000070", "Q966F9", "WBGene00000071" ] }, "reaction_10511347": { "compartment": "compartment_876", "id": "reaction_10511347", "reactome": "R-CEL-170672", "name": "Galpha-olf:GTP binds to adenylate cyclase and activates it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10511283", "species_10508992" ], "products": [ "species_10511344" ], "modifiers": [ [ "species_10508992", "catalyst" ] ], "additional_components": [ "Q7KPV0", "WBGene00001745", "V6CLB7", "WBGene00020997", "species_29438", "species_114632", "Q19523", "WBGene00000068", "O16880", "WBGene00000069", "G5EE33", "WBGene00000070", "Q966F9", "WBGene00000071", "species_114632", "Q19523", "WBGene00000068", "O16880", "WBGene00000069", "G5EE33", "WBGene00000070", "Q966F9", "WBGene00000071", "Q7KPV0", "WBGene00001745", "V6CLB7", "WBGene00020997", "species_29438", "species_114632", "Q19523", "WBGene00000068", "O16880", "WBGene00000069", "G5EE33", "WBGene00000070", "Q966F9", "WBGene00000071" ] }, "reaction_10511363": { "compartment": "compartment_876", "id": "reaction_10511363", "reactome": "R-CEL-170685", "name": "Adenylaye cyclase increases the GTPase activity of G alpha-olf", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10511344" ], "products": [ "species_10511358", "species_29372" ], "modifiers": [ [ "species_10511344", "catalyst" ] ], "additional_components": [ "species_114632", "Q19523", "WBGene00000068", "O16880", "WBGene00000069", "G5EE33", "WBGene00000070", "Q966F9", "WBGene00000071", "Q7KPV0", "WBGene00001745", "V6CLB7", "WBGene00020997", "species_29438", "species_114632", "Q19523", "WBGene00000068", "O16880", "WBGene00000069", "G5EE33", "WBGene00000070", "Q966F9", "WBGene00000071", "Q7KPV0", "WBGene00001745", "V6CLB7", "WBGene00020997", "species_29420", "species_114632", "Q19523", "WBGene00000068", "O16880", "WBGene00000069", "G5EE33", "WBGene00000070", "Q966F9", "WBGene00000071", "Q7KPV0", "WBGene00001745", "V6CLB7", "WBGene00020997", "species_29438" ] }, "reaction_10511356": { "compartment": "compartment_876", "id": "reaction_10511356", "reactome": "R-CEL-170676", "name": "Adenylate cyclase converts ATP into cyclic AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592" ], "products": [ "species_111294", "species_30389" ], "modifiers": [ [ "species_10511344", "catalyst" ] ], "additional_components": [ "species_114632", "Q19523", "WBGene00000068", "O16880", "WBGene00000069", "G5EE33", "WBGene00000070", "Q966F9", "WBGene00000071", "Q7KPV0", "WBGene00001745", "V6CLB7", "WBGene00020997", "species_29438" ] }, "reaction_10509072": { "compartment": "compartment_70101", "id": "reaction_10509072", "reactome": "R-CEL-112037", "name": "Inactivation of PLC beta", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10508939" ], "products": [ "species_10509070", "species_29372", "species_10508913" ], "modifiers": [], "additional_components": [ "G5EBH0", "WBGene00001177", "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196", "species_29438", "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196", "species_29420", "WBGene00001177" ] }, "reaction_10508942": { "compartment": "compartment_70101", "id": "reaction_10508942", "reactome": "R-CEL-111879", "name": "PIP2 hydrolysis", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_179856" ], "products": [ "species_114520", "species_112275" ], "modifiers": [ [ "species_10508939", "catalyst" ] ], "additional_components": [ "G5EBH0", "WBGene00001177", "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196", "species_29438" ] }, "reaction_10509032": { "compartment": "compartment_70101", "id": "reaction_10509032", "reactome": "R-CEL-111962", "name": "PDE4A,C,D hydrolyse cAMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_30389" ], "products": [ "species_76577" ], "modifiers": [ [ "species_10509025", "catalyst" ] ], "additional_components": [ "WBGene00020114" ] }, "reaction_10572525": { "compartment": "compartment_70101", "id": "reaction_10572525", "reactome": "R-CEL-9644869", "name": "p-S54-PDE4B hydrolyses cAMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_30389" ], "products": [ "species_76577" ], "modifiers": [ [ "species_10512059", "catalyst" ] ], "additional_components": [ "WBGene00020114" ] }, "reaction_10512062": { "compartment": "compartment_70101", "id": "reaction_10512062", "reactome": "R-CEL-177284", "name": "PKA phosphorylates PDE4B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10512056" ], "products": [ "species_10512059", "species_29370" ], "modifiers": [ [ "species_10508954", "catalyst" ] ], "additional_components": [ "WBGene00020114", "WBGene00020114", "WBGene00002189" ] }, "reaction_10510834": { "compartment": "compartment_70101", "id": "reaction_10510834", "reactome": "R-CEL-167429", "name": "The receptor:G-protein complex binds GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10510829" ], "products": [ "species_10509169" ], "modifiers": [ [ "species_10508935", "catalyst" ] ], "additional_components": [ "Q20841", "WBGene00018886", "H9G358", "WBGene00018089", "A0A0K3AXD3", "WBGene00011372", "Q23033", "WBGene00020086", "P34311", "WBGene00018089", "A0A2C9C3A4", "WBGene00018089", "Q9XVQ0", "WBGene00018089", "Q09502", "WBGene00008065", "A0A3B1DQQ4", "WBGene00006864", "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "Q20841", "WBGene00018886", "H9G358", "WBGene00018089", "A0A0K3AXD3", "WBGene00011372", "Q23033", "WBGene00020086", "P34311", "WBGene00018089", "A0A2C9C3A4", "WBGene00018089", "Q9XVQ0", "WBGene00018089", "Q09502", "WBGene00008065", "A0A3B1DQQ4", "WBGene00006864", "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196", "species_29438", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196" ] }, "reaction_10510836": { "compartment": "compartment_947587", "id": "reaction_10510836", "reactome": "R-CEL-167433", "name": "G-protein beta-gamma subunits rebind the alpha-GDP subunit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509070", "species_10509165" ], "products": [ "species_10510817" ], "modifiers": [], "additional_components": [ "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196", "species_29420", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196", "species_29420" ] }, "reaction_10510831": { "compartment": "compartment_70101", "id": "reaction_10510831", "reactome": "R-CEL-167419", "name": "The receptor:G-protein complex releases GDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10510819" ], "products": [ "species_10510829", "species_29420" ], "modifiers": [], "additional_components": [ "P17343", "WBGene00001679", "P54406", "WBGene00001681", "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196", "species_29420", "Q20841", "WBGene00018886", "H9G358", "WBGene00018089", "A0A0K3AXD3", "WBGene00011372", "Q23033", "WBGene00020086", "P34311", "WBGene00018089", "A0A2C9C3A4", "WBGene00018089", "Q9XVQ0", "WBGene00018089", "Q09502", "WBGene00008065", "A0A3B1DQQ4", "WBGene00006864", "Q20841", "WBGene00018886", "H9G358", "WBGene00018089", "A0A0K3AXD3", "WBGene00011372", "Q23033", "WBGene00020086", "P34311", "WBGene00018089", "A0A2C9C3A4", "WBGene00018089", "Q9XVQ0", "WBGene00018089", "Q09502", "WBGene00008065", "A0A3B1DQQ4", "WBGene00006864", "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196", "P17343", "WBGene00001679", "P54406", "WBGene00001681" ] }, "reaction_10510815": { "compartment": "compartment_947587", "id": "reaction_10510815", "reactome": "R-CEL-167415", "name": "G-protein alpha subunit is inactivated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29420", "species_10508937" ], "products": [ "species_29438", "species_10509070" ], "modifiers": [ [ "species_10508935", "catalyst" ] ], "additional_components": [ "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196", "species_29438", "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196", "species_29420", "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196" ] }, "reaction_10524194": { "compartment": "compartment_172574", "id": "reaction_10524194", "reactome": "R-CEL-435171", "name": "NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_445829" ], "products": [ "species_445832", "species_1470067" ], "modifiers": [ [ "species_10524191", "catalyst" ] ], "additional_components": [ "species_216785", "species_113531", "species_266099", "species_216785", "species_266099", "species_113531", "Q21433", "WBGene00004877", "Q21434", "WBGene00004876", "Q95XG8", "WBGene00004878" ] }, "reaction_10532076": { "compartment": "compartment_1222693", "id": "reaction_10532076", "reactome": "R-CEL-1222516", "name": "Intraphagosomal pH is lowered to 5 by V-ATPase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106" ], "products": [ "species_1470067" ], "modifiers": [ [ "species_10532073", "catalyst" ] ], "additional_components": [ "Q9XXU9", "WBGene00006920", "Q22494", "WBGene00020507", "Q23680", "WBGene00006918", "P34462", "WBGene00010130", "Q9XW92", "WBGene00013025", "Q19626", "WBGene00006921", "Q9N5A0", "WBGene00004959", "Q95X44", "WBGene00006917", "P91303", "WBGene00006919", "G5EDB8", "WBGene00006913", "Q20591", "WBGene00009882", "C0HLB3", "WBGene00006911", "C0HLB4", "WBGene00006912", "P30628", "WBGene00006768", "B2MZD0", "WBGene00006916", "G5EEK9", "WBGene00006914", "G5EGP4", "WBGene00006915", "Q95YD5", "WBGene00016258" ] }, "reaction_10558402": { "compartment": "compartment_21994", "id": "reaction_10558402", "reactome": "R-CEL-6789031", "name": "Membrane-bound myeloperoxidase (MPO) produces hypochlorous acid (HOCl)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1222719", "species_6788973", "species_1470067" ], "products": [ "species_1222475", "species_6789150" ], "modifiers": [ [ "species_10558399", "catalyst" ] ], "additional_components": [ "P91060", "WBGene00015841", "Q1ENI8", "WBGene00004256", "Q20616", "WBGene00009897", "Q23490", "WBGene00022743", "G5EG78", "WBGene00004257", "H2KZ53", "WBGene00017968", "CHEBI:55376" ] }, "reaction_10558405": { "compartment": "compartment_1222282", "id": "reaction_10558405", "reactome": "R-CEL-6789126", "name": "Myeloperoxidase (MPO) produces hypochlorous acid (HOCl)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1222719", "species_6788973", "species_1470067" ], "products": [ "species_1222475", "species_6789150" ], "modifiers": [ [ "species_10558397", "catalyst" ] ], "additional_components": [ "P91060", "WBGene00015841", "Q1ENI8", "WBGene00004256", "Q20616", "WBGene00009897", "Q23490", "WBGene00022743", "G5EG78", "WBGene00004257", "H2KZ53", "WBGene00017968", "CHEBI:55376" ] }, "reaction_10568119": { "compartment": "compartment_1222282", "id": "reaction_10568119", "reactome": "R-CEL-8933635", "name": "Myeloperoxidase (MPO) catalyzes oxidation of nitrite to nitrogen dioxide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1222719", "species_1470067", "species_6789221" ], "products": [ "species_8933637", "species_1222475" ], "modifiers": [ [ "species_10558397", "catalyst" ] ], "additional_components": [ "P91060", "WBGene00015841", "Q1ENI8", "WBGene00004256", "Q20616", "WBGene00009897", "Q23490", "WBGene00022743", "G5EG78", "WBGene00004257", "H2KZ53", "WBGene00017968", "CHEBI:55376" ] }, "reaction_10558407": { "compartment": "compartment_21994", "id": "reaction_10558407", "reactome": "R-CEL-6789136", "name": "Myeloperoxidase (MPO) binds to the bacterial cell surface", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10558397", "species_983438" ], "products": [ "species_10558399" ], "modifiers": [], "additional_components": [ "P91060", "WBGene00015841", "Q1ENI8", "WBGene00004256", "Q20616", "WBGene00009897", "Q23490", "WBGene00022743", "G5EG78", "WBGene00004257", "H2KZ53", "WBGene00017968", "CHEBI:55376", "P91060", "WBGene00015841", "Q1ENI8", "WBGene00004256", "Q20616", "WBGene00009897", "Q23490", "WBGene00022743", "G5EG78", "WBGene00004257", "H2KZ53", "WBGene00017968", "CHEBI:55376" ] }, "reaction_10565654": { "compartment": "compartment_984", "id": "reaction_10565654", "reactome": "R-CEL-8855490", "name": "Lactoperoxidase (LPO) produces OSCN-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351629", "species_8855492" ], "products": [ "species_109276", "species_8855489" ], "modifiers": [ [ "species_10565651", "catalyst" ] ], "additional_components": [ "G5EG78", "WBGene00004257", "H2KZ53", "WBGene00017968", "P91060", "WBGene00015841", "Q1ENI8", "WBGene00004256", "Q20616", "WBGene00009897", "Q23490", "WBGene00022743", "CHEBI:55376" ] }, "reaction_10573254": { "compartment": "compartment_7660", "id": "reaction_10573254", "reactome": "R-CEL-9699579", "name": "AKT phosphorylates FOXO3 downstream of FLT3 ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10514276" ], "products": [ "species_113582", "species_10514290" ], "modifiers": [ [ "species_10514266", "catalyst" ] ], "additional_components": [ "WBGene00000912", "WBGene00000912", "G4S4W1", "WBGene00016980", "Q17941", "WBGene00000102", "Q9XTG7", "WBGene00000103" ] }, "reaction_10571976": { "compartment": "compartment_70101", "id": "reaction_10571976", "reactome": "R-CEL-9607304", "name": "SOS1-mediated nucleotide exchange of RAS downstream of FLT3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10512175", "species_29438" ], "products": [ "species_29420", "species_10511481" ], "modifiers": [ [ "species_10554987", "catalyst" ] ], "additional_components": [ "species_29420", "P22981", "WBGene00002335", "species_29438", "P22981", "WBGene00002335", "A0A1I6CMA1", "WBGene00020678", "G5EGT9", "WBGene00003007", "P29355", "WBGene00004774", "Q9N5D3", "WBGene00004947" ] }, "reaction_10573256": { "compartment": "compartment_7660", "id": "reaction_10573256", "reactome": "R-CEL-9699581", "name": "AKT-phosphorylated FOXO3 translocates to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10514290" ], "products": [ "species_10572151" ], "modifiers": [], "additional_components": [ "WBGene00000912", "WBGene00000912" ] }, "reaction_10573245": { "compartment": "compartment_876", "id": "reaction_10573245", "reactome": "R-CEL-9698170", "name": "Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508492", "species_10506890" ], "products": [ "species_10543896" ], "modifiers": [], "additional_components": [ "G5EDP9", "WBGene00000001", "A0A1I6CMA1", "WBGene00020678", "G5EGT9", "WBGene00003007", "P29355", "WBGene00004774", "G5EDJ4", "WBGene00004928", "WBGene00000090", "Q94125", "WBGene00000090", "G5EDP9", "WBGene00000001", "A0A1I6CMA1", "WBGene00020678", "G5EGT9", "WBGene00003007", "P29355", "WBGene00004774", "G5EDJ4", "WBGene00004928" ] }, "reaction_10573264": { "compartment": "compartment_70101", "id": "reaction_10573264", "reactome": "R-CEL-9705507", "name": "PDE3B hydrolyses cAMP to AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_30389" ], "products": [ "species_76577" ], "modifiers": [ [ "species_10573261", "catalyst" ] ], "additional_components": [ "WBGene00008443" ] }, "reaction_10572293": { "compartment": "compartment_70101", "id": "reaction_10572293", "reactome": "R-CEL-9629675", "name": "PDE3A hydrolyses cAMP to AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_30389" ], "products": [ "species_76577" ], "modifiers": [ [ "species_10572290", "catalyst" ] ], "additional_components": [ "WBGene00008443" ] }, "reaction_10573321": { "compartment": "compartment_70101", "id": "reaction_10573321", "reactome": "R-CEL-9708261", "name": "PDE4A hydrolyses cAMP to AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_30389" ], "products": [ "species_76577" ], "modifiers": [ [ "species_10509025", "catalyst" ] ], "additional_components": [ "WBGene00020114" ] }, "reaction_10521818": { "compartment": "compartment_70101", "id": "reaction_10521818", "reactome": "R-CEL-418553", "name": "cAMP degradation by Phosphodiesterases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_30389" ], "products": [ "species_76577" ], "modifiers": [ [ "species_10521815", "catalyst" ] ], "additional_components": [ "Q22000", "WBGene00020114", "Q9N2V9", "WBGene00022389", "P30645", "WBGene00011146", "P91119", "WBGene00016328", "O18696", "WBGene00011433" ] }, "reaction_10571834": { "compartment": "compartment_70101", "id": "reaction_10571834", "reactome": "R-CEL-9603279", "name": "PIP3 recruits PDK1 and AKT to the membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179838", "species_10515193", "species_10520802" ], "products": [ "species_10571832" ], "modifiers": [], "additional_components": [ "WBGene00021022", "G4S4W1", "WBGene00016980", "Q17941", "WBGene00000102", "Q9XTG7", "WBGene00000103", "Q9UA62", "WBGene00021022", "Q17941", "WBGene00000102", "Q9XTG7", "WBGene00000103", "G4S4W1", "WBGene00016980", "species_179838" ] }, "reaction_10521037": { "compartment": "compartment_70101", "id": "reaction_10521037", "reactome": "R-CEL-392300", "name": "G beta:gamma activated PI3Kgamma converts PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10521034", "catalyst" ] ], "additional_components": [ "Q94125", "WBGene00000090", "P17343", "WBGene00001679", "P54406", "WBGene00001681" ] }, "reaction_10570240": { "compartment": "compartment_876", "id": "reaction_10570240", "reactome": "R-CEL-8964634", "name": "CDC42 binds GNB/GNG:PAK1:ARHGEF6 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10570223", "species_10512277" ], "products": [ "species_10570229" ], "modifiers": [], "additional_components": [ "Q21430", "WBGene00010776", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "WBGene00000390", "Q05062", "WBGene00000390", "Q21430", "WBGene00010776", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "P17343", "WBGene00001679", "P54406", "WBGene00001681" ] }, "reaction_10570227": { "compartment": "compartment_876", "id": "reaction_10570227", "reactome": "R-CEL-8964599", "name": "Active PAK1 and Active CDC42 dissociates from GNB/GNG:PAK1:ARHGEF6:CDC42 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10570225" ], "products": [ "species_10520670", "species_10509165", "species_10516119", "species_10512279" ], "modifiers": [], "additional_components": [ "Q05062", "WBGene00000390", "species_29438", "Q21430", "WBGene00010776", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "WBGene00010776", "Q05062", "WBGene00000390", "species_29438" ] }, "reaction_10570232": { "compartment": "compartment_876", "id": "reaction_10570232", "reactome": "R-CEL-8964604", "name": "CDC42 in GNB/GNG:PAK1:ARHGEF6:CDC42 is activated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10570229" ], "products": [ "species_10570225" ], "modifiers": [ [ "species_10570229", "catalyst" ] ], "additional_components": [ "Q05062", "WBGene00000390", "Q21430", "WBGene00010776", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "Q05062", "WBGene00000390", "species_29438", "Q21430", "WBGene00010776", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "Q05062", "WBGene00000390", "Q21430", "WBGene00010776", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "P17343", "WBGene00001679", "P54406", "WBGene00001681" ] }, "reaction_10570234": { "compartment": "compartment_70101", "id": "reaction_10570234", "reactome": "R-CEL-8964605", "name": "PAK1:ARHGEF6 complex binds G-protein beta-gamma complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509165", "species_10570221" ], "products": [ "species_10570223" ], "modifiers": [], "additional_components": [ "P17343", "WBGene00001679", "P54406", "WBGene00001681", "Q21430", "WBGene00010776", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "Q21430", "WBGene00010776", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "P17343", "WBGene00001679", "P54406", "WBGene00001681" ] }, "reaction_10570236": { "compartment": "compartment_876", "id": "reaction_10570236", "reactome": "R-CEL-8964614", "name": "PAK1 in GNB/GNG:PAK1:ARHGEF6:Active CDC42 is activated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10570225" ], "products": [ "species_10570225" ], "modifiers": [], "additional_components": [ "Q05062", "WBGene00000390", "species_29438", "Q21430", "WBGene00010776", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "Q05062", "WBGene00000390", "species_29438", "Q21430", "WBGene00010776", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "P17343", "WBGene00001679", "P54406", "WBGene00001681" ] }, "reaction_10570238": { "compartment": "compartment_70101", "id": "reaction_10570238", "reactome": "R-CEL-8964619", "name": "PAK1 binds ARHGEF6", "reversible": "false", "notes": "", "reactants": [ "species_10520670", "species_10516119" ], "products": [ "species_10570221" ], "modifiers": [], "additional_components": [ "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "WBGene00010776", "Q21430", "WBGene00010776", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911" ] }, "reaction_10528036": { "compartment": "compartment_876", "id": "reaction_10528036", "reactome": "R-CEL-751001", "name": "Inactive G alpha (i) reassociates with G beta:gamma", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509165", "species_10511349" ], "products": [ "species_10519835" ], "modifiers": [], "additional_components": [ "P17343", "WBGene00001679", "P54406", "WBGene00001681", "species_29420", "O76584", "WBGene00001673", "Q9BIG5", "WBGene00001666", "Q21917", "WBGene00001669", "P91907", "WBGene00001677", "Q93743", "WBGene00001668", "Q20907", "WBGene00001670", "Q9BIG2", "WBGene00001676", "Q20910", "WBGene00001671", "species_29420", "O76584", "WBGene00001673", "Q9BIG5", "WBGene00001666", "Q21917", "WBGene00001669", "P91907", "WBGene00001677", "Q93743", "WBGene00001668", "Q20907", "WBGene00001670", "Q9BIG2", "WBGene00001676", "Q20910", "WBGene00001671", "P17343", "WBGene00001679", "P54406", "WBGene00001681" ] }, "reaction_10570486": { "compartment": "compartment_876", "id": "reaction_10570486", "reactome": "R-CEL-8982019", "name": "Active G alpha (i)i1/i2/i3 binds RGS proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10570468", "species_10511329" ], "products": [ "species_10570484" ], "modifiers": [], "additional_components": [ "Q18563", "WBGene00004349", "G5ECK9", "WBGene00004351", "Q23376", "WBGene00004352", "O45523", "WBGene00004353", "Q8WQC0", "WBGene00004350", "O45524", "WBGene00004354", "P49808", "WBGene00004345", "P49809", "WBGene00001179", "A0A5S9MNH1", "WBGene00004347", "O17589", "WBGene00001145", "species_29438", "O76584", "WBGene00001673", "Q9BIG5", "WBGene00001666", "Q21917", "WBGene00001669", "P91907", "WBGene00001677", "Q93743", "WBGene00001668", "Q20907", "WBGene00001670", "Q9BIG2", "WBGene00001676", "Q20910", "WBGene00001671", "species_29438", "O76584", "WBGene00001673", "Q9BIG5", "WBGene00001666", "Q21917", "WBGene00001669", "P91907", "WBGene00001677", "Q93743", "WBGene00001668", "Q20907", "WBGene00001670", "Q9BIG2", "WBGene00001676", "Q20910", "WBGene00001671", "Q18563", "WBGene00004349", "G5ECK9", "WBGene00004351", "Q23376", "WBGene00004352", "O45523", "WBGene00004353", "Q8WQC0", "WBGene00004350", "O45524", "WBGene00004354", "P49808", "WBGene00004345", "P49809", "WBGene00001179", "A0A5S9MNH1", "WBGene00004347", "O17589", "WBGene00001145" ] }, "reaction_10570217": { "compartment": "compartment_876", "id": "reaction_10570217", "reactome": "R-CEL-8964242", "name": "G protein alpha (i)-SRC complex catalyzes SRC to p-Y416-SRC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10570204", "species_113592" ], "products": [ "species_29370", "species_10570214" ], "modifiers": [ [ "species_10570204", "catalyst" ] ], "additional_components": [ "species_29438", "O76584", "WBGene00001673", "Q9BIG5", "WBGene00001666", "Q21917", "WBGene00001669", "P91907", "WBGene00001677", "Q93743", "WBGene00001668", "Q20907", "WBGene00001670", "Q9BIG2", "WBGene00001676", "Q20910", "WBGene00001671", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "species_29438", "O76584", "WBGene00001673", "Q9BIG5", "WBGene00001666", "Q21917", "WBGene00001669", "P91907", "WBGene00001677", "Q93743", "WBGene00001668", "Q20907", "WBGene00001670", "Q9BIG2", "WBGene00001676", "Q20910", "WBGene00001671", "Q9N3S5", "WBGene00021635", "G5EE56", "WBGene00005077", "species_29438", "O76584", "WBGene00001673", "Q9BIG5", "WBGene00001666", "Q21917", "WBGene00001669", "P91907", "WBGene00001677", "Q93743", "WBGene00001668", "Q20907", "WBGene00001670", "Q9BIG2", "WBGene00001676", "Q20910", "WBGene00001671", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635" ] }, "reaction_10570489": { "compartment": "compartment_876", "id": "reaction_10570489", "reactome": "R-CEL-8982020", "name": "G alpha (i)i1/i2/i3 in G (i):RGS complex is inactivated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10570484" ], "products": [ "species_29372", "species_10570470" ], "modifiers": [ [ "species_10570484", "catalyst" ] ], "additional_components": [ "species_29438", "O76584", "WBGene00001673", "Q9BIG5", "WBGene00001666", "Q21917", "WBGene00001669", "P91907", "WBGene00001677", "Q93743", "WBGene00001668", "Q20907", "WBGene00001670", "Q9BIG2", "WBGene00001676", "Q20910", "WBGene00001671", "Q18563", "WBGene00004349", "G5ECK9", "WBGene00004351", "Q23376", "WBGene00004352", "O45523", "WBGene00004353", "Q8WQC0", "WBGene00004350", "O45524", "WBGene00004354", "P49808", "WBGene00004345", "P49809", "WBGene00001179", "A0A5S9MNH1", "WBGene00004347", "O17589", "WBGene00001145", "Q18563", "WBGene00004349", "G5ECK9", "WBGene00004351", "Q23376", "WBGene00004352", "O45523", "WBGene00004353", "Q8WQC0", "WBGene00004350", "O45524", "WBGene00004354", "P49808", "WBGene00004345", "P49809", "WBGene00001179", "A0A5S9MNH1", "WBGene00004347", "O17589", "WBGene00001145", "species_29420", "O76584", "WBGene00001673", "Q9BIG5", "WBGene00001666", "Q21917", "WBGene00001669", "P91907", "WBGene00001677", "Q93743", "WBGene00001668", "Q20907", "WBGene00001670", "Q9BIG2", "WBGene00001676", "Q20910", "WBGene00001671", "species_29438", "O76584", "WBGene00001673", "Q9BIG5", "WBGene00001666", "Q21917", "WBGene00001669", "P91907", "WBGene00001677", "Q93743", "WBGene00001668", "Q20907", "WBGene00001670", "Q9BIG2", "WBGene00001676", "Q20910", "WBGene00001671", "Q18563", "WBGene00004349", "G5ECK9", "WBGene00004351", "Q23376", "WBGene00004352", "O45523", "WBGene00004353", "Q8WQC0", "WBGene00004350", "O45524", "WBGene00004354", "P49808", "WBGene00004345", "P49809", "WBGene00001179", "A0A5S9MNH1", "WBGene00004347", "O17589", "WBGene00001145" ] }, "reaction_10570472": { "compartment": "compartment_876", "id": "reaction_10570472", "reactome": "R-CEL-8982012", "name": "G alpha (i):RGS dissociates to inactive G alpha (i)i1/i2/i3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10570470" ], "products": [ "species_10511349", "species_10570468" ], "modifiers": [], "additional_components": [ "Q18563", "WBGene00004349", "G5ECK9", "WBGene00004351", "Q23376", "WBGene00004352", "O45523", "WBGene00004353", "Q8WQC0", "WBGene00004350", "O45524", "WBGene00004354", "P49808", "WBGene00004345", "P49809", "WBGene00001179", "A0A5S9MNH1", "WBGene00004347", "O17589", "WBGene00001145", "species_29420", "O76584", "WBGene00001673", "Q9BIG5", "WBGene00001666", "Q21917", "WBGene00001669", "P91907", "WBGene00001677", "Q93743", "WBGene00001668", "Q20907", "WBGene00001670", "Q9BIG2", "WBGene00001676", "Q20910", "WBGene00001671", "species_29420", "O76584", "WBGene00001673", "Q9BIG5", "WBGene00001666", "Q21917", "WBGene00001669", "P91907", "WBGene00001677", "Q93743", "WBGene00001668", "Q20907", "WBGene00001670", "Q9BIG2", "WBGene00001676", "Q20910", "WBGene00001671", "Q18563", "WBGene00004349", "G5ECK9", "WBGene00004351", "Q23376", "WBGene00004352", "O45523", "WBGene00004353", "Q8WQC0", "WBGene00004350", "O45524", "WBGene00004354", "P49808", "WBGene00004345", "P49809", "WBGene00001179", "A0A5S9MNH1", "WBGene00004347", "O17589", "WBGene00001145" ] }, "reaction_10570219": { "compartment": "compartment_70101", "id": "reaction_10570219", "reactome": "R-CEL-8964329", "name": "G protein alpha (i)-SRC complex dissociates to G protein alpha (i) and Active SRC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10570214" ], "products": [ "species_10570212", "species_10511329" ], "modifiers": [], "additional_components": [ "species_29438", "O76584", "WBGene00001673", "Q9BIG5", "WBGene00001666", "Q21917", "WBGene00001669", "P91907", "WBGene00001677", "Q93743", "WBGene00001668", "Q20907", "WBGene00001670", "Q9BIG2", "WBGene00001676", "Q20910", "WBGene00001671", "Q9N3S5", "WBGene00021635", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "G5EE56", "WBGene00005077", "species_29438", "O76584", "WBGene00001673", "Q9BIG5", "WBGene00001666", "Q21917", "WBGene00001669", "P91907", "WBGene00001677", "Q93743", "WBGene00001668", "Q20907", "WBGene00001670", "Q9BIG2", "WBGene00001676", "Q20910", "WBGene00001671" ] }, "reaction_10519851": { "compartment": "compartment_947587", "id": "reaction_10519851", "reactome": "R-CEL-380073", "name": "Liganded Gi-activating GPCR acts as a GEF for Gi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10519837" ], "products": [ "species_29420", "species_10519841" ], "modifiers": [ [ "species_10519837", "catalyst" ], [ "species_10519847", "inhibitor" ] ], "additional_components": [ "species_390899", "Q9U7D5", "WBGene00001519", "species_266074", "species_266013", "CHEBI:15650", "H2KZ99", "WBGene00016570", "O02213", "WBGene00004777", "Q19084", "WBGene00017157", "species_209794", "species_209789", "Q23033", "WBGene00020086", "A0A0K3AXD3", "WBGene00011372", "Q9XVQ0", "WBGene00018089", "A0A2C9C3A4", "WBGene00018089", "A0A3B1DQQ4", "WBGene00006864", "H9G358", "WBGene00018089", "P34311", "WBGene00018089", "Q09502", "WBGene00008065", "Q20841", "WBGene00018886", "species_879629", "G5ECB2", "WBGene00022675", "H2L0Q3", "WBGene00021528", "species_352003", "A1IMB8", "WBGene00021152", "Q09630", "WBGene00003232", "species_113552", "species_372533", "Q7JP61", "WBGene00006411", "E7EM37", "WBGene00001053", "G5EGH0", "WBGene00004779", "species_380585", "species_351601", "Q6RYS9", "WBGene00020506", "species_83909", "Q10042", "WBGene00019287", "Q19295", "WBGene00019287", "Q19779", "WBGene00017779", "Q1ZXT2", "WBGene00011878", "species_29420", "O76584", "WBGene00001673", "Q9BIG5", "WBGene00001666", "Q21917", "WBGene00001669", "P91907", "WBGene00001677", "Q93743", "WBGene00001668", "Q20907", "WBGene00001670", "Q9BIG2", "WBGene00001676", "Q20910", "WBGene00001671", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "species_390899", "Q9U7D5", "WBGene00001519", "species_266074", "species_266013", "CHEBI:15650", "H2KZ99", "WBGene00016570", "O02213", "WBGene00004777", "Q19084", "WBGene00017157", "species_209794", "species_209789", "Q23033", "WBGene00020086", "A0A0K3AXD3", "WBGene00011372", "Q9XVQ0", "WBGene00018089", "A0A2C9C3A4", "WBGene00018089", "A0A3B1DQQ4", "WBGene00006864", "H9G358", "WBGene00018089", "P34311", "WBGene00018089", "Q09502", "WBGene00008065", "Q20841", "WBGene00018886", "species_879629", "G5ECB2", "WBGene00022675", "H2L0Q3", "WBGene00021528", "species_352003", "A1IMB8", "WBGene00021152", "Q09630", "WBGene00003232", "species_113552", "species_372533", "Q7JP61", "WBGene00006411", "E7EM37", "WBGene00001053", "G5EGH0", "WBGene00004779", "species_380585", "species_351601", "Q6RYS9", "WBGene00020506", "species_83909", "Q10042", "WBGene00019287", "Q19295", "WBGene00019287", "Q19779", "WBGene00017779", "Q1ZXT2", "WBGene00011878", "species_29438", "O76584", "WBGene00001673", "Q9BIG5", "WBGene00001666", "Q21917", "WBGene00001669", "P91907", "WBGene00001677", "Q93743", "WBGene00001668", "Q20907", "WBGene00001670", "Q9BIG2", "WBGene00001676", "Q20910", "WBGene00001671", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "species_390899", "Q9U7D5", "WBGene00001519", "species_266074", "species_266013", "CHEBI:15650", "H2KZ99", "WBGene00016570", "O02213", "WBGene00004777", "Q19084", "WBGene00017157", "species_209794", "species_209789", "Q23033", "WBGene00020086", "A0A0K3AXD3", "WBGene00011372", "Q9XVQ0", "WBGene00018089", "A0A2C9C3A4", "WBGene00018089", "A0A3B1DQQ4", "WBGene00006864", "H9G358", "WBGene00018089", "P34311", "WBGene00018089", "Q09502", "WBGene00008065", "Q20841", "WBGene00018886", "species_879629", "G5ECB2", "WBGene00022675", "H2L0Q3", "WBGene00021528", "species_352003", "A1IMB8", "WBGene00021152", "Q09630", "WBGene00003232", "species_113552", "species_372533", "Q7JP61", "WBGene00006411", "E7EM37", "WBGene00001053", "G5EGH0", "WBGene00004779", "species_380585", "species_351601", "Q6RYS9", "WBGene00020506", "species_83909", "Q10042", "WBGene00019287", "Q19295", "WBGene00019287", "Q19779", "WBGene00017779", "Q1ZXT2", "WBGene00011878", "species_29420", "O76584", "WBGene00001673", "Q9BIG5", "WBGene00001666", "Q21917", "WBGene00001669", "P91907", "WBGene00001677", "Q93743", "WBGene00001668", "Q20907", "WBGene00001670", "Q9BIG2", "WBGene00001676", "Q20910", "WBGene00001671", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "WBGene00000092" ] }, "reaction_10528028": { "compartment": "compartment_984", "id": "reaction_10528028", "reactome": "R-CEL-749454", "name": "The Ligand:GPCR:Gi complex dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10519841" ], "products": [ "species_10509165", "species_10519833", "species_10511329" ], "modifiers": [], "additional_components": [ "species_390899", "Q9U7D5", "WBGene00001519", "species_266074", "species_266013", "CHEBI:15650", "H2KZ99", "WBGene00016570", "O02213", "WBGene00004777", "Q19084", "WBGene00017157", "species_209794", "species_209789", "Q23033", "WBGene00020086", "A0A0K3AXD3", "WBGene00011372", "Q9XVQ0", "WBGene00018089", "A0A2C9C3A4", "WBGene00018089", "A0A3B1DQQ4", "WBGene00006864", "H9G358", "WBGene00018089", "P34311", "WBGene00018089", "Q09502", "WBGene00008065", "Q20841", "WBGene00018886", "species_879629", "G5ECB2", "WBGene00022675", "H2L0Q3", "WBGene00021528", "species_352003", "A1IMB8", "WBGene00021152", "Q09630", "WBGene00003232", "species_113552", "species_372533", "Q7JP61", "WBGene00006411", "E7EM37", "WBGene00001053", "G5EGH0", "WBGene00004779", "species_380585", "species_351601", "Q6RYS9", "WBGene00020506", "species_83909", "Q10042", "WBGene00019287", "Q19295", "WBGene00019287", "Q19779", "WBGene00017779", "Q1ZXT2", "WBGene00011878", "species_29438", "O76584", "WBGene00001673", "Q9BIG5", "WBGene00001666", "Q21917", "WBGene00001669", "P91907", "WBGene00001677", "Q93743", "WBGene00001668", "Q20907", "WBGene00001670", "Q9BIG2", "WBGene00001676", "Q20910", "WBGene00001671", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "species_390899", "Q9U7D5", "WBGene00001519", "species_266074", "species_266013", "CHEBI:15650", "H2KZ99", "WBGene00016570", "O02213", "WBGene00004777", "Q19084", "WBGene00017157", "species_209794", "species_209789", "Q23033", "WBGene00020086", "A0A0K3AXD3", "WBGene00011372", "Q9XVQ0", "WBGene00018089", "A0A2C9C3A4", "WBGene00018089", "A0A3B1DQQ4", "WBGene00006864", "H9G358", "WBGene00018089", "P34311", "WBGene00018089", "Q09502", "WBGene00008065", "Q20841", "WBGene00018886", "species_879629", "G5ECB2", "WBGene00022675", "H2L0Q3", "WBGene00021528", "species_352003", "A1IMB8", "WBGene00021152", "Q09630", "WBGene00003232", "species_113552", "species_372533", "Q7JP61", "WBGene00006411", "E7EM37", "WBGene00001053", "G5EGH0", "WBGene00004779", "species_380585", "species_351601", "Q6RYS9", "WBGene00020506", "species_83909", "Q10042", "WBGene00019287", "Q19295", "WBGene00019287", "Q19779", "WBGene00017779", "Q1ZXT2", "WBGene00011878", "species_29438", "O76584", "WBGene00001673", "Q9BIG5", "WBGene00001666", "Q21917", "WBGene00001669", "P91907", "WBGene00001677", "Q93743", "WBGene00001668", "Q20907", "WBGene00001670", "Q9BIG2", "WBGene00001676", "Q20910", "WBGene00001671" ] }, "reaction_10528030": { "compartment": "compartment_876", "id": "reaction_10528030", "reactome": "R-CEL-749456", "name": "Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10519835", "species_10519833" ], "products": [ "species_10519837" ], "modifiers": [], "additional_components": [ "species_29420", "O76584", "WBGene00001673", "Q9BIG5", "WBGene00001666", "Q21917", "WBGene00001669", "P91907", "WBGene00001677", "Q93743", "WBGene00001668", "Q20907", "WBGene00001670", "Q9BIG2", "WBGene00001676", "Q20910", "WBGene00001671", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "species_390899", "Q9U7D5", "WBGene00001519", "species_266074", "species_266013", "CHEBI:15650", "H2KZ99", "WBGene00016570", "O02213", "WBGene00004777", "Q19084", "WBGene00017157", "species_209794", "species_209789", "Q23033", "WBGene00020086", "A0A0K3AXD3", "WBGene00011372", "Q9XVQ0", "WBGene00018089", "A0A2C9C3A4", "WBGene00018089", "A0A3B1DQQ4", "WBGene00006864", "H9G358", "WBGene00018089", "P34311", "WBGene00018089", "Q09502", "WBGene00008065", "Q20841", "WBGene00018886", "species_879629", "G5ECB2", "WBGene00022675", "H2L0Q3", "WBGene00021528", "species_352003", "A1IMB8", "WBGene00021152", "Q09630", "WBGene00003232", "species_113552", "species_372533", "Q7JP61", "WBGene00006411", "E7EM37", "WBGene00001053", "G5EGH0", "WBGene00004779", "species_380585", "species_351601", "Q6RYS9", "WBGene00020506", "species_83909", "Q10042", "WBGene00019287", "Q19295", "WBGene00019287", "Q19779", "WBGene00017779", "Q1ZXT2", "WBGene00011878", "species_390899", "Q9U7D5", "WBGene00001519", "species_266074", "species_266013", "CHEBI:15650", "H2KZ99", "WBGene00016570", "O02213", "WBGene00004777", "Q19084", "WBGene00017157", "species_209794", "species_209789", "Q23033", "WBGene00020086", "A0A0K3AXD3", "WBGene00011372", "Q9XVQ0", "WBGene00018089", "A0A2C9C3A4", "WBGene00018089", "A0A3B1DQQ4", "WBGene00006864", "H9G358", "WBGene00018089", "P34311", "WBGene00018089", "Q09502", "WBGene00008065", "Q20841", "WBGene00018886", "species_879629", "G5ECB2", "WBGene00022675", "H2L0Q3", "WBGene00021528", "species_352003", "A1IMB8", "WBGene00021152", "Q09630", "WBGene00003232", "species_113552", "species_372533", "Q7JP61", "WBGene00006411", "E7EM37", "WBGene00001053", "G5EGH0", "WBGene00004779", "species_380585", "species_351601", "Q6RYS9", "WBGene00020506", "species_83909", "Q10042", "WBGene00019287", "Q19295", "WBGene00019287", "Q19779", "WBGene00017779", "Q1ZXT2", "WBGene00011878", "species_29420", "O76584", "WBGene00001673", "Q9BIG5", "WBGene00001666", "Q21917", "WBGene00001669", "P91907", "WBGene00001677", "Q93743", "WBGene00001668", "Q20907", "WBGene00001670", "Q9BIG2", "WBGene00001676", "Q20910", "WBGene00001671", "P17343", "WBGene00001679", "P54406", "WBGene00001681" ] }, "reaction_10570497": { "compartment": "compartment_876", "id": "reaction_10570497", "reactome": "R-CEL-8982025", "name": "G alpha (q) in G (q):RGS complex is inactivated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10570476" ], "products": [ "species_10570494", "species_29372" ], "modifiers": [ [ "species_10570476", "catalyst" ] ], "additional_components": [ "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196", "species_29438", "Q18563", "WBGene00004349", "G5ECK9", "WBGene00004351", "Q23376", "WBGene00004352", "O45523", "WBGene00004353", "Q8WQC0", "WBGene00004350", "O45524", "WBGene00004354", "P49808", "WBGene00004345", "A0A5S9MNH1", "WBGene00004347", "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196", "Q18563", "WBGene00004349", "G5ECK9", "WBGene00004351", "Q23376", "WBGene00004352", "O45523", "WBGene00004353", "Q8WQC0", "WBGene00004350", "O45524", "WBGene00004354", "P49808", "WBGene00004345", "A0A5S9MNH1", "WBGene00004347", "species_29420", "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196", "species_29438", "Q18563", "WBGene00004349", "G5ECK9", "WBGene00004351", "Q23376", "WBGene00004352", "O45523", "WBGene00004353", "Q8WQC0", "WBGene00004350", "O45524", "WBGene00004354", "P49808", "WBGene00004345", "A0A5S9MNH1", "WBGene00004347" ] }, "reaction_10519681": { "compartment": "compartment_70101", "id": "reaction_10519681", "reactome": "R-CEL-379048", "name": "Liganded Gq/11-activating GPCRs act as GEFs for Gq/11", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10519672" ], "products": [ "species_29420", "species_10519674" ], "modifiers": [ [ "species_10519678", "catalyst" ] ], "additional_components": [ "species_266056", "Q20325", "WBGene00018344", "Q9XUK8", "WBGene00012275", "P91096", "WBGene00016037", "species_380585", "species_266074", "species_266013", "CHEBI:15650", "H2KZ99", "WBGene00016570", "species_70106", "species_417891", "G5EG10", "WBGene00003233", "species_113552", "species_372533", "Q9U7D5", "WBGene00001519", "CHEBI:28716", "species_390435", "CHEBI:28875", "CHEBI:53460", "CHEBI:27997", "CHEBI:16196", "species_2066763", "CHEBI:53487", "CHEBI:53486", "species_8934421", "CHEBI:53488", "CHEBI:28661", "CHEBI:28364", "CHEBI:27432", "O17899", "WBGene00010329", "species_158602", "species_419777", "P90745", "WBGene00007006", "species_209794", "species_209789", "G5EBX8", "WBGene00008890", "species_29420", "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "species_266056", "Q20325", "WBGene00018344", "Q9XUK8", "WBGene00012275", "P91096", "WBGene00016037", "species_380585", "species_266074", "species_266013", "CHEBI:15650", "H2KZ99", "WBGene00016570", "species_70106", "species_417891", "G5EG10", "WBGene00003233", "species_113552", "species_372533", "Q9U7D5", "WBGene00001519", "CHEBI:28716", "species_390435", "CHEBI:28875", "CHEBI:53460", "CHEBI:27997", "CHEBI:16196", "species_2066763", "CHEBI:53487", "CHEBI:53486", "species_8934421", "CHEBI:53488", "CHEBI:28661", "CHEBI:28364", "CHEBI:27432", "O17899", "WBGene00010329", "species_158602", "species_419777", "P90745", "WBGene00007006", "species_209794", "species_209789", "G5EBX8", "WBGene00008890", "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196", "species_29438", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "species_266013", "Q20325", "WBGene00018344", "Q9XUK8", "WBGene00012275" ] }, "reaction_10528034": { "compartment": "compartment_876", "id": "reaction_10528034", "reactome": "R-CEL-750993", "name": "Inactive G alpha (q) reassociates with G beta:gamma", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509165", "species_10509557" ], "products": [ "species_10509559" ], "modifiers": [], "additional_components": [ "P17343", "WBGene00001679", "P54406", "WBGene00001681", "species_29420", "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196", "species_29420", "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196", "P17343", "WBGene00001679", "P54406", "WBGene00001681" ] }, "reaction_10570499": { "compartment": "compartment_876", "id": "reaction_10570499", "reactome": "R-CEL-8982026", "name": "G alpha (q):RGS dissociates to inactive G alpha (q)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10570494" ], "products": [ "species_10570474", "species_10509557" ], "modifiers": [], "additional_components": [ "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196", "Q18563", "WBGene00004349", "G5ECK9", "WBGene00004351", "Q23376", "WBGene00004352", "O45523", "WBGene00004353", "Q8WQC0", "WBGene00004350", "O45524", "WBGene00004354", "P49808", "WBGene00004345", "A0A5S9MNH1", "WBGene00004347", "species_29420", "Q18563", "WBGene00004349", "G5ECK9", "WBGene00004351", "Q23376", "WBGene00004352", "O45523", "WBGene00004353", "Q8WQC0", "WBGene00004350", "O45524", "WBGene00004354", "P49808", "WBGene00004345", "A0A5S9MNH1", "WBGene00004347", "species_29420", "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196" ] }, "reaction_10521540": { "compartment": "compartment_70101", "id": "reaction_10521540", "reactome": "R-CEL-400586", "name": "G alpha (q) binds to Trio family RhoGEFs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508937", "species_10521536" ], "products": [ "species_10521538" ], "modifiers": [], "additional_components": [ "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196", "species_29438", "WBGene00006805", "O61528", "WBGene00006805", "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196", "species_29438" ] }, "reaction_10527910": { "compartment": "compartment_876", "id": "reaction_10527910", "reactome": "R-CEL-749448", "name": "Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509559", "species_10519670" ], "products": [ "species_10519672" ], "modifiers": [], "additional_components": [ "species_29420", "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "species_266056", "Q20325", "WBGene00018344", "Q9XUK8", "WBGene00012275", "P91096", "WBGene00016037", "species_380585", "species_266074", "species_266013", "CHEBI:15650", "H2KZ99", "WBGene00016570", "species_70106", "species_417891", "G5EG10", "WBGene00003233", "species_113552", "species_372533", "Q9U7D5", "WBGene00001519", "CHEBI:28716", "species_390435", "CHEBI:28875", "CHEBI:53460", "CHEBI:27997", "CHEBI:16196", "species_2066763", "CHEBI:53487", "CHEBI:53486", "species_8934421", "CHEBI:53488", "CHEBI:28661", "CHEBI:28364", "CHEBI:27432", "O17899", "WBGene00010329", "species_158602", "species_419777", "P90745", "WBGene00007006", "species_209794", "species_209789", "G5EBX8", "WBGene00008890", "species_266056", "Q20325", "WBGene00018344", "Q9XUK8", "WBGene00012275", "P91096", "WBGene00016037", "species_380585", "species_266074", "species_266013", "CHEBI:15650", "H2KZ99", "WBGene00016570", "species_70106", "species_417891", "G5EG10", "WBGene00003233", "species_113552", "species_372533", "Q9U7D5", "WBGene00001519", "CHEBI:28716", "species_390435", "CHEBI:28875", "CHEBI:53460", "CHEBI:27997", "CHEBI:16196", "species_2066763", "CHEBI:53487", "CHEBI:53486", "species_8934421", "CHEBI:53488", "CHEBI:28661", "CHEBI:28364", "CHEBI:27432", "O17899", "WBGene00010329", "species_158602", "species_419777", "P90745", "WBGene00007006", "species_209794", "species_209789", "G5EBX8", "WBGene00008890", "species_29420", "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196", "P17343", "WBGene00001679", "P54406", "WBGene00001681" ] }, "reaction_10543427": { "compartment": "compartment_70101", "id": "reaction_10543427", "reactome": "R-CEL-2179407", "name": "SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10512175", "species_29438" ], "products": [ "species_29420", "species_10511481" ], "modifiers": [ [ "species_10543424", "catalyst" ] ], "additional_components": [ "species_29420", "P22981", "WBGene00002335", "species_29438", "P22981", "WBGene00002335", "P29355", "WBGene00004774", "Q9N5D3", "WBGene00004947", "P24348", "WBGene00002299" ] }, "reaction_10543444": { "compartment": "compartment_876", "id": "reaction_10543444", "reactome": "R-CEL-2179413", "name": "Activated PKC-alpha activate MMP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10543441" ], "products": [ "species_10534164" ], "modifiers": [ [ "species_10521475", "catalyst" ] ], "additional_components": [ "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "Q21182", "WBGene00194737", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "P90980", "WBGene00004033", "species_114519" ] }, "reaction_10521477": { "compartment": "compartment_876", "id": "reaction_10521477", "reactome": "R-CEL-400015", "name": "Diacylgycerol activates Protein kinase C, alpha type", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_114519", "species_10509044" ], "products": [ "species_10521475" ], "modifiers": [], "additional_components": [ "WBGene00004033", "P90980", "WBGene00004033", "species_114519" ] }, "reaction_10570478": { "compartment": "compartment_876", "id": "reaction_10570478", "reactome": "R-CEL-8982017", "name": "Active G alpha (q) binds RGS proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10570474", "species_10508937" ], "products": [ "species_10570476" ], "modifiers": [], "additional_components": [ "Q18563", "WBGene00004349", "G5ECK9", "WBGene00004351", "Q23376", "WBGene00004352", "O45523", "WBGene00004353", "Q8WQC0", "WBGene00004350", "O45524", "WBGene00004354", "P49808", "WBGene00004345", "A0A5S9MNH1", "WBGene00004347", "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196", "species_29438", "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196", "species_29438", "Q18563", "WBGene00004349", "G5ECK9", "WBGene00004351", "Q23376", "WBGene00004352", "O45523", "WBGene00004353", "Q8WQC0", "WBGene00004350", "O45524", "WBGene00004354", "P49808", "WBGene00004345", "A0A5S9MNH1", "WBGene00004347" ] }, "reaction_10528019": { "compartment": "compartment_984", "id": "reaction_10528019", "reactome": "R-CEL-749452", "name": "The Ligand:GPCR:Gq complex dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10519674" ], "products": [ "species_10509165", "species_10527995", "species_10508937", "species_10528017" ], "modifiers": [], "additional_components": [ "species_266056", "Q20325", "WBGene00018344", "Q9XUK8", "WBGene00012275", "P91096", "WBGene00016037", "species_380585", "species_266074", "species_266013", "CHEBI:15650", "H2KZ99", "WBGene00016570", "species_70106", "species_417891", "G5EG10", "WBGene00003233", "species_113552", "species_372533", "Q9U7D5", "WBGene00001519", "CHEBI:28716", "species_390435", "CHEBI:28875", "CHEBI:53460", "CHEBI:27997", "CHEBI:16196", "species_2066763", "CHEBI:53487", "CHEBI:53486", "species_8934421", "CHEBI:53488", "CHEBI:28661", "CHEBI:28364", "CHEBI:27432", "O17899", "WBGene00010329", "species_158602", "species_419777", "P90745", "WBGene00007006", "species_209794", "species_209789", "G5EBX8", "WBGene00008890", "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196", "species_29438", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "Q20325", "WBGene00018344", "Q9XUK8", "WBGene00012275", "P91096", "WBGene00016037", "Q18701", "WBGene00016747", "O17239", "WBGene00019616", "Q18130", "WBGene00016044", "G5EG10", "WBGene00003233", "A0A3B1DQQ4", "WBGene00006864", "H9G358", "WBGene00018089", "P34311", "WBGene00018089", "Q09502", "WBGene00008065", "Q20841", "WBGene00018886", "Q23033", "WBGene00020086", "A0A0K3AXD3", "WBGene00011372", "Q9XVQ0", "WBGene00018089", "A0A2C9C3A4", "WBGene00018089", "G5EDI0", "WBGene00007395", "O62403", "WBGene00013782", "Q9U7D5", "WBGene00001519", "Q03566", "WBGene00006576", "Q95YD7", "WBGene00016265", "H2KZ99", "WBGene00016570", "O17899", "WBGene00010329", "G5EBX8", "WBGene00008890", "P90745", "WBGene00007006", "O44731", "WBGene00018798", "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196", "species_29438", "species_74016", "species_113582", "species_419777", "species_29358", "species_113552", "species_70106", "species_216785", "species_380585", "CHEBI:28716", "species_390435", "CHEBI:28875", "CHEBI:53460", "CHEBI:27997", "CHEBI:16196", "species_2066763", "CHEBI:53487", "CHEBI:53486", "species_8934421", "CHEBI:53488", "CHEBI:28661", "CHEBI:28364", "CHEBI:27432", "species_29444", "species_29468", "species_29498", "species_417891", "species_209794", "species_209789", "species_158602", "species_8869214", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "A9Z1L1", "WBGene00005648", "G5ECY2", "WBGene00005644", "species_29460", "CHEBI:31011", "CHEBI:30772", "species_427486", "CHEBI:30768", "CHEBI:50122", "species_33549", "CHEBI:42504", "CHEBI:6498", "Q10651", "WBGene00000149", "species_372533", "species_266074", "species_266013", "CHEBI:15650", "species_266056", "CHEBI:17120", "species_209849", "species_390899", "CHEBI:15627", "species_879535", "species_265287" ] }, "reaction_10521878": { "compartment": "compartment_876", "id": "reaction_10521878", "reactome": "R-CEL-418582", "name": "G alpha (q) auto-inactivates by hydrolysing GTP to GDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508937" ], "products": [ "species_10509557" ], "modifiers": [ [ "species_10508937", "catalyst" ], [ "species_10521876", "catalyst" ] ], "additional_components": [ "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196", "species_29438", "species_29420", "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196", "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196", "species_29438", "P49808", "WBGene00004345", "Q18563", "WBGene00004349", "G5ECK9", "WBGene00004351", "Q23376", "WBGene00004352", "O45523", "WBGene00004353", "Q8WQC0", "WBGene00004350", "O45524", "WBGene00004354", "A0A5S9MNH1", "WBGene00004347" ] }, "reaction_10521559": { "compartment": "compartment_70101", "id": "reaction_10521559", "reactome": "R-CEL-416358", "name": "G alpha (q) inhibits PI3K alpha", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10506892", "species_10508937" ], "products": [ "species_10521557" ], "modifiers": [], "additional_components": [ "G5EDP9", "WBGene00000001", "Q94125", "WBGene00000090", "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196", "species_29438", "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196", "species_29438", "G5EDP9", "WBGene00000001", "Q94125", "WBGene00000090" ] }, "reaction_10509655": { "compartment": "compartment_876", "id": "reaction_10509655", "reactome": "R-CEL-114688", "name": "PLC-beta hydrolyses PIP2 to DAG and IP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509650" ], "products": [ "species_10509652" ], "modifiers": [ [ "species_10508939", "catalyst" ] ], "additional_components": [ "species_179856", "G5EBH0", "WBGene00001177", "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196", "species_29438", "species_114519", "species_114520", "G5EBH0", "WBGene00001177", "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196", "species_29438", "G5EBH0", "WBGene00001177", "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196", "species_29438" ] }, "reaction_10521563": { "compartment": "compartment_876", "id": "reaction_10521563", "reactome": "R-CEL-416516", "name": "GRK2 sequesters activated Gq", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509037", "species_10508937" ], "products": [ "species_10521561" ], "modifiers": [], "additional_components": [ "WBGene00001709", "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196", "species_29438", "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196", "species_29438", "Q09639", "WBGene00001709" ] }, "reaction_10528032": { "compartment": "compartment_876", "id": "reaction_10528032", "reactome": "R-CEL-750988", "name": "Inactive G alpha (z) reassociates with G beta:gamma", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10527902", "species_10509165" ], "products": [ "species_10527904" ], "modifiers": [], "additional_components": [ "O76584", "WBGene00001673", "P91907", "WBGene00001677", "Q20907", "WBGene00001670", "Q20910", "WBGene00001671", "Q21917", "WBGene00001669", "Q93743", "WBGene00001668", "Q9BIG2", "WBGene00001676", "species_29420", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "O76584", "WBGene00001673", "P91907", "WBGene00001677", "Q20907", "WBGene00001670", "Q20910", "WBGene00001671", "Q21917", "WBGene00001669", "Q93743", "WBGene00001668", "Q9BIG2", "WBGene00001676", "species_29420" ] }, "reaction_10570482": { "compartment": "compartment_876", "id": "reaction_10570482", "reactome": "R-CEL-8982018", "name": "G alpha (z):RGS complex dissociates to give inactive G alpha (z)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10570480" ], "products": [ "species_10527902", "species_10570434" ], "modifiers": [], "additional_components": [ "O76584", "WBGene00001673", "P91907", "WBGene00001677", "Q20907", "WBGene00001670", "Q20910", "WBGene00001671", "Q21917", "WBGene00001669", "Q93743", "WBGene00001668", "Q9BIG2", "WBGene00001676", "Q8WQC0", "WBGene00004350", "G5ECK9", "WBGene00004351", "O45523", "WBGene00004353", "O45524", "WBGene00004354", "Q18563", "WBGene00004349", "Q23376", "WBGene00004352", "species_29420", "O76584", "WBGene00001673", "P91907", "WBGene00001677", "Q20907", "WBGene00001670", "Q20910", "WBGene00001671", "Q21917", "WBGene00001669", "Q93743", "WBGene00001668", "Q9BIG2", "WBGene00001676", "species_29420", "Q8WQC0", "WBGene00004350", "G5ECK9", "WBGene00004351", "O45523", "WBGene00004353", "O45524", "WBGene00004354", "Q18563", "WBGene00004349", "Q23376", "WBGene00004352" ] }, "reaction_10527908": { "compartment": "compartment_876", "id": "reaction_10527908", "reactome": "R-CEL-749446", "name": "Liganded Gz-activating GPCRs bind inactive heterotrimeric G-protein Gz", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10519749", "species_10527904" ], "products": [ "species_10527906" ], "modifiers": [], "additional_components": [ "O02213", "WBGene00004777", "Q19084", "WBGene00017157", "species_209794", "species_209789", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "O76584", "WBGene00001673", "P91907", "WBGene00001677", "Q20907", "WBGene00001670", "Q20910", "WBGene00001671", "Q21917", "WBGene00001669", "Q93743", "WBGene00001668", "Q9BIG2", "WBGene00001676", "species_29420", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "O76584", "WBGene00001673", "P91907", "WBGene00001677", "Q20907", "WBGene00001670", "Q20910", "WBGene00001671", "Q21917", "WBGene00001669", "Q93743", "WBGene00001668", "Q9BIG2", "WBGene00001676", "species_29420", "O02213", "WBGene00004777", "Q19084", "WBGene00017157", "species_209794", "species_209789" ] }, "reaction_10521015": { "compartment": "compartment_876", "id": "reaction_10521015", "reactome": "R-CEL-392064", "name": "G alpha (z) inhibits adenylate cyclase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10521011", "species_10508992" ], "products": [ "species_10521013" ], "modifiers": [], "additional_components": [ "O76584", "WBGene00001673", "P91907", "WBGene00001677", "Q20907", "WBGene00001670", "Q20910", "WBGene00001671", "Q21917", "WBGene00001669", "Q93743", "WBGene00001668", "Q9BIG2", "WBGene00001676", "species_29438", "species_114632", "Q19523", "WBGene00000068", "O16880", "WBGene00000069", "G5EE33", "WBGene00000070", "Q966F9", "WBGene00000071", "species_114632", "Q19523", "WBGene00000068", "O16880", "WBGene00000069", "G5EE33", "WBGene00000070", "Q966F9", "WBGene00000071", "O76584", "WBGene00001673", "P91907", "WBGene00001677", "Q20907", "WBGene00001670", "Q20910", "WBGene00001671", "Q21917", "WBGene00001669", "Q93743", "WBGene00001668", "Q9BIG2", "WBGene00001676", "species_29438" ] }, "reaction_10570438": { "compartment": "compartment_876", "id": "reaction_10570438", "reactome": "R-CEL-8981892", "name": "Active G alpha (z) binds RGS proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10570434", "species_10521011" ], "products": [ "species_10570436" ], "modifiers": [], "additional_components": [ "Q8WQC0", "WBGene00004350", "G5ECK9", "WBGene00004351", "O45523", "WBGene00004353", "O45524", "WBGene00004354", "Q18563", "WBGene00004349", "Q23376", "WBGene00004352", "O76584", "WBGene00001673", "P91907", "WBGene00001677", "Q20907", "WBGene00001670", "Q20910", "WBGene00001671", "Q21917", "WBGene00001669", "Q93743", "WBGene00001668", "Q9BIG2", "WBGene00001676", "species_29438", "O76584", "WBGene00001673", "P91907", "WBGene00001677", "Q20907", "WBGene00001670", "Q20910", "WBGene00001671", "Q21917", "WBGene00001669", "Q93743", "WBGene00001668", "Q9BIG2", "WBGene00001676", "species_29438", "Q8WQC0", "WBGene00004350", "G5ECK9", "WBGene00004351", "O45523", "WBGene00004353", "O45524", "WBGene00004354", "Q18563", "WBGene00004349", "Q23376", "WBGene00004352" ] }, "reaction_10528026": { "compartment": "compartment_70101", "id": "reaction_10528026", "reactome": "R-CEL-749453", "name": "Liganded Gz-activating GPCR acts as a GEF for Gz", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10527906" ], "products": [ "species_29420", "species_10528023" ], "modifiers": [ [ "species_10527906", "catalyst" ] ], "additional_components": [ "P17343", "WBGene00001679", "P54406", "WBGene00001681", "O76584", "WBGene00001673", "P91907", "WBGene00001677", "Q20907", "WBGene00001670", "Q20910", "WBGene00001671", "Q21917", "WBGene00001669", "Q93743", "WBGene00001668", "Q9BIG2", "WBGene00001676", "species_29420", "O02213", "WBGene00004777", "Q19084", "WBGene00017157", "species_209794", "species_209789", "O76584", "WBGene00001673", "P91907", "WBGene00001677", "Q20907", "WBGene00001670", "Q20910", "WBGene00001671", "Q21917", "WBGene00001669", "Q93743", "WBGene00001668", "Q9BIG2", "WBGene00001676", "species_29438", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "O02213", "WBGene00004777", "Q19084", "WBGene00017157", "species_209794", "species_209789", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "O76584", "WBGene00001673", "P91907", "WBGene00001677", "Q20907", "WBGene00001670", "Q20910", "WBGene00001671", "Q21917", "WBGene00001669", "Q93743", "WBGene00001668", "Q9BIG2", "WBGene00001676", "species_29420", "O02213", "WBGene00004777", "Q19084", "WBGene00017157", "species_209794", "species_209789" ] }, "reaction_10528042": { "compartment": "compartment_984", "id": "reaction_10528042", "reactome": "R-CEL-751024", "name": "The Ligand:GPCR:Gz complex dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10528023" ], "products": [ "species_10509165", "species_390627", "species_10519747", "species_10521011" ], "modifiers": [], "additional_components": [ "O76584", "WBGene00001673", "P91907", "WBGene00001677", "Q20907", "WBGene00001670", "Q20910", "WBGene00001671", "Q21917", "WBGene00001669", "Q93743", "WBGene00001668", "Q9BIG2", "WBGene00001676", "species_29438", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "O02213", "WBGene00004777", "Q19084", "WBGene00017157", "species_209794", "species_209789", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "species_209794", "species_209789", "O02213", "WBGene00004777", "Q19084", "WBGene00017157", "O76584", "WBGene00001673", "P91907", "WBGene00001677", "Q20907", "WBGene00001670", "Q20910", "WBGene00001671", "Q21917", "WBGene00001669", "Q93743", "WBGene00001668", "Q9BIG2", "WBGene00001676", "species_29438" ] }, "reaction_10570492": { "compartment": "compartment_876", "id": "reaction_10570492", "reactome": "R-CEL-8982021", "name": "G alpha (z) in G alpha (z):RGS complex is inactivated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10570436" ], "products": [ "species_29372", "species_10570480" ], "modifiers": [ [ "species_10570436", "catalyst" ] ], "additional_components": [ "O76584", "WBGene00001673", "P91907", "WBGene00001677", "Q20907", "WBGene00001670", "Q20910", "WBGene00001671", "Q21917", "WBGene00001669", "Q93743", "WBGene00001668", "Q9BIG2", "WBGene00001676", "species_29438", "Q8WQC0", "WBGene00004350", "G5ECK9", "WBGene00004351", "O45523", "WBGene00004353", "O45524", "WBGene00004354", "Q18563", "WBGene00004349", "Q23376", "WBGene00004352", "O76584", "WBGene00001673", "P91907", "WBGene00001677", "Q20907", "WBGene00001670", "Q20910", "WBGene00001671", "Q21917", "WBGene00001669", "Q93743", "WBGene00001668", "Q9BIG2", "WBGene00001676", "Q8WQC0", "WBGene00004350", "G5ECK9", "WBGene00004351", "O45523", "WBGene00004353", "O45524", "WBGene00004354", "Q18563", "WBGene00004349", "Q23376", "WBGene00004352", "species_29420", "O76584", "WBGene00001673", "P91907", "WBGene00001677", "Q20907", "WBGene00001670", "Q20910", "WBGene00001671", "Q21917", "WBGene00001669", "Q93743", "WBGene00001668", "Q9BIG2", "WBGene00001676", "species_29438", "Q8WQC0", "WBGene00004350", "G5ECK9", "WBGene00004351", "O45523", "WBGene00004353", "O45524", "WBGene00004354", "Q18563", "WBGene00004349", "Q23376", "WBGene00004352" ] }, "reaction_10528049": { "compartment": "compartment_70101", "id": "reaction_10528049", "reactome": "R-CEL-751029", "name": "Liganded G12/13-activating GPCR acts as a GEF for G12/13", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10528044" ], "products": [ "species_29420", "species_10528038" ], "modifiers": [ [ "species_10528044", "catalyst" ] ], "additional_components": [ "species_29420", "Q19572", "WBGene00001674", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "species_209794", "species_209789", "G5EBX8", "WBGene00008890", "species_209794", "species_209789", "G5EBX8", "WBGene00008890", "Q19572", "WBGene00001674", "species_29438", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "species_29420", "Q19572", "WBGene00001674", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "species_209794", "species_209789", "G5EBX8", "WBGene00008890" ] }, "reaction_10509505": { "compartment": "compartment_70101", "id": "reaction_10509505", "reactome": "R-CEL-114544", "name": "p115-RhoGEF activation of RHOA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10509486" ], "products": [ "species_29420", "species_10509488" ], "modifiers": [ [ "species_10509502", "catalyst" ] ], "additional_components": [ "Q22038", "WBGene00004357", "species_29420", "Q22038", "WBGene00004357", "species_29438", "Q19572", "WBGene00001674", "species_29438", "G5EFE1", "WBGene00006468" ] }, "reaction_10521106": { "compartment": "compartment_876", "id": "reaction_10521106", "reactome": "R-CEL-398185", "name": "LARG binds plexin B1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10518605", "species_10521100" ], "products": [ "species_10521104" ], "modifiers": [], "additional_components": [ "O45657", "WBGene00004048", "U4PRY7", "WBGene00004047", "G5EFE1", "WBGene00006468", "H2L0P5", "WBGene00022391", "Q19572", "WBGene00001674", "species_29438", "G5EFE1", "WBGene00006468", "H2L0P5", "WBGene00022391", "Q19572", "WBGene00001674", "species_29438", "O45657", "WBGene00004048", "U4PRY7", "WBGene00004047" ] }, "reaction_10509507": { "compartment": "compartment_70101", "id": "reaction_10509507", "reactome": "R-CEL-114548", "name": "G alpha (13) activates Rho guanine nucleotide exchange factor 1 (p115-RhoGEF)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509500", "species_10509495" ], "products": [ "species_10509502" ], "modifiers": [], "additional_components": [ "WBGene00006468", "Q19572", "WBGene00001674", "species_29438", "Q19572", "WBGene00001674", "species_29438", "G5EFE1", "WBGene00006468" ] }, "reaction_10528051": { "compartment": "compartment_876", "id": "reaction_10528051", "reactome": "R-CEL-751039", "name": "Inactive G alpha (12/13) reassociates with G beta:gamma", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509165", "species_10521820" ], "products": [ "species_10509524" ], "modifiers": [], "additional_components": [ "P17343", "WBGene00001679", "P54406", "WBGene00001681", "species_29420", "Q19572", "WBGene00001674", "species_29420", "Q19572", "WBGene00001674", "P17343", "WBGene00001679", "P54406", "WBGene00001681" ] }, "reaction_10521958": { "compartment": "compartment_70101", "id": "reaction_10521958", "reactome": "R-CEL-419166", "name": "GEFs activate RhoA,B,C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10521599", "species_29438" ], "products": [ "species_29420", "species_10509488" ], "modifiers": [ [ "species_10516176", "catalyst" ] ], "additional_components": [ "species_29420", "Q22038", "WBGene00004357", "Q22038", "WBGene00004357", "species_29438", "G5EFE1", "WBGene00006468", "H2L0P5", "WBGene00022391", "G5EF62", "WBGene00009337", "Q9U3P2", "WBGene00007750", "X5LV34", "WBGene00001366", "S6EZU2", "WBGene00006476", "Q45FX5", "WBGene00006887", "Q21653", "WBGene00019832", "A0A0K3AQN0", "WBGene00013682", "O01847", "WBGene00015704", "Q965J0", "WBGene00019487", "Q21430", "WBGene00010776", "H2KYI7", "WBGene00006496", "Q9N5D3", "WBGene00004947", "Q9U364", "WBGene00002297", "A0A0K3AS36", "Y116A8C.36d", "Q19572", "WBGene00001674", "species_29438" ] }, "reaction_10528040": { "compartment": "compartment_984", "id": "reaction_10528040", "reactome": "R-CEL-751019", "name": "The Ligand:GPCR:G12/13 complex dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10528038" ], "products": [ "species_10509165", "species_10521096", "species_10519575", "species_791498" ], "modifiers": [], "additional_components": [ "species_209794", "species_209789", "G5EBX8", "WBGene00008890", "Q19572", "WBGene00001674", "species_29438", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "Q19572", "WBGene00001674", "species_29438", "WBGene00008890", "species_209794", "species_209789", "CHEBI:15627" ] }, "reaction_10528046": { "compartment": "compartment_876", "id": "reaction_10528046", "reactome": "R-CEL-751027", "name": "Liganded G12/13-activating GPCRs bind inactive heterotrimeric G-protein G12/13", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10519581", "species_10509524" ], "products": [ "species_10528044" ], "modifiers": [], "additional_components": [ "species_209794", "species_209789", "G5EBX8", "WBGene00008890", "species_29420", "Q19572", "WBGene00001674", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "species_29420", "Q19572", "WBGene00001674", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "species_209794", "species_209789", "G5EBX8", "WBGene00008890" ] }, "reaction_10521102": { "compartment": "compartment_70101", "id": "reaction_10521102", "reactome": "R-CEL-398184", "name": "LARG activation by G alpha 12/13", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10521096", "species_10516134" ], "products": [ "species_10521100" ], "modifiers": [], "additional_components": [ "Q19572", "WBGene00001674", "species_29438", "G5EFE1", "WBGene00006468", "H2L0P5", "WBGene00022391", "G5EFE1", "WBGene00006468", "H2L0P5", "WBGene00022391", "Q19572", "WBGene00001674", "species_29438" ] }, "reaction_10521823": { "compartment": "compartment_876", "id": "reaction_10521823", "reactome": "R-CEL-418574", "name": "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10521096" ], "products": [ "species_10521820" ], "modifiers": [ [ "species_10521096", "catalyst" ] ], "additional_components": [ "Q19572", "WBGene00001674", "species_29438", "species_29420", "Q19572", "WBGene00001674", "Q19572", "WBGene00001674", "species_29438" ] }, "reaction_10528246": { "compartment": "compartment_876", "id": "reaction_10528246", "reactome": "R-CEL-879674", "name": "CD97 binds CD55", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10528242", "species_10524688" ], "products": [ "species_10528244" ], "modifiers": [], "additional_components": [ "Q22328", "WBGene00002976", "A0A1N7SYP5", "WBGene00009500", "Q18849", "WBGene00009500", "WBGene00002252", "G5ECX0", "WBGene00002252", "Q22328", "WBGene00002976", "A0A1N7SYP5", "WBGene00009500", "Q18849", "WBGene00009500" ] }, "reaction_10524696": { "compartment": "compartment_984", "id": "reaction_10524696", "reactome": "R-CEL-444773", "name": "EGF-TM7 receptors bind chondroitin sulphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_444761", "species_10524686" ], "products": [ "species_10524694" ], "modifiers": [], "additional_components": [ "WBGene00002252", "G5ECX0", "WBGene00002252", "species_444761" ] }, "reaction_10518464": { "compartment": "compartment_984", "id": "reaction_10518464", "reactome": "R-CEL-373075", "name": "Metabotropic glutamate receptors bind glutamate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_210382", "species_10518460" ], "products": [ "species_10518462" ], "modifiers": [], "additional_components": [ "G5EG10", "WBGene00003233", "A1IMB8", "WBGene00021152", "Q09630", "WBGene00003232", "G5EG10", "WBGene00003233", "A1IMB8", "WBGene00021152", "Q09630", "WBGene00003232", "species_113552" ] }, "reaction_10522001": { "compartment": "compartment_876", "id": "reaction_10522001", "reactome": "R-CEL-420688", "name": "GABAB heterodimeric receptor binds GABA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352003", "species_10519829" ], "products": [ "species_10519831" ], "modifiers": [], "additional_components": [ "G5ECB2", "WBGene00022675", "H2L0Q3", "WBGene00021528", "G5ECB2", "WBGene00022675", "H2L0Q3", "WBGene00021528", "species_352003" ] }, "reaction_10524672": { "compartment": "compartment_984", "id": "reaction_10524672", "reactome": "R-CEL-444654", "name": "G-protein coupled bile acid receptor binds lithocholic acid", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_444840", "species_10524668" ], "products": [ "species_10524670" ], "modifiers": [], "additional_components": [ "species_5357505", "species_193451", "species_176655", "CHEBI:16755", "Q10042", "WBGene00019287", "Q19295", "WBGene00019287", "Q19779", "WBGene00017779", "Q1ZXT2", "WBGene00011878", "Q10042", "WBGene00019287", "Q19295", "WBGene00019287", "Q19779", "WBGene00017779", "Q1ZXT2", "WBGene00011878", "species_5357505", "species_193451", "species_176655", "CHEBI:16755" ] }, "reaction_10563088": { "compartment": "compartment_984", "id": "reaction_10563088", "reactome": "R-CEL-6805205", "name": "GPR35 binds kynurenic acid", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10563084", "species_6805204" ], "products": [ "species_10563086" ], "modifiers": [], "additional_components": [ "WBGene00016570", "species_6805204", "H2KZ99", "WBGene00016570" ] }, "reaction_10520929": { "compartment": "compartment_984", "id": "reaction_10520929", "reactome": "R-CEL-391934", "name": "DP2 receptor can bind PGD2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_416911", "species_10519813" ], "products": [ "species_10519815" ], "modifiers": [], "additional_components": [ "Q23033", "WBGene00020086", "A0A0K3AXD3", "WBGene00011372", "Q9XVQ0", "WBGene00018089", "A0A2C9C3A4", "WBGene00018089", "A0A3B1DQQ4", "WBGene00006864", "H9G358", "WBGene00018089", "P34311", "WBGene00018089", "Q09502", "WBGene00008065", "Q20841", "WBGene00018886", "Q23033", "WBGene00020086", "A0A0K3AXD3", "WBGene00011372", "Q9XVQ0", "WBGene00018089", "A0A2C9C3A4", "WBGene00018089", "A0A3B1DQQ4", "WBGene00006864", "H9G358", "WBGene00018089", "P34311", "WBGene00018089", "Q09502", "WBGene00008065", "Q20841", "WBGene00018886", "species_879629" ] }, "reaction_10520931": { "compartment": "compartment_984", "id": "reaction_10520931", "reactome": "R-CEL-391937", "name": "UDP/CysLT receptor can bind cysteinyl leukotrienes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10519635", "species_416372" ], "products": [ "species_10519793" ], "modifiers": [], "additional_components": [ "WBGene00016570", "species_266074", "species_266013", "CHEBI:15650", "species_266074", "species_266013", "CHEBI:15650", "H2KZ99", "WBGene00016570" ] }, "reaction_10520933": { "compartment": "compartment_984", "id": "reaction_10520933", "reactome": "R-CEL-391941", "name": "BLT receptors can bind LTB4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10519651", "species_416436" ], "products": [ "species_10519653" ], "modifiers": [], "additional_components": [ "Q20325", "WBGene00018344", "Q9XUK8", "WBGene00012275", "species_266056", "Q20325", "WBGene00018344", "Q9XUK8", "WBGene00012275" ] }, "reaction_10520935": { "compartment": "compartment_984", "id": "reaction_10520935", "reactome": "R-CEL-391943", "name": "CYSLT2 binds LTC4,LTD4,LTE4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10519631", "species_416372" ], "products": [ "species_10519633" ], "modifiers": [], "additional_components": [ "Q20325", "WBGene00018344", "Q9XUK8", "WBGene00012275", "species_266074", "species_266013", "CHEBI:15650", "species_266074", "species_266013", "CHEBI:15650", "Q20325", "WBGene00018344", "Q9XUK8", "WBGene00012275" ] }, "reaction_10573113": { "compartment": "compartment_984", "id": "reaction_10573113", "reactome": "R-CEL-9684627", "name": "CYSLTR1 binds CYSLTR1 antagonists", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10519623", "species_9684615" ], "products": [ "species_10573111" ], "modifiers": [], "additional_components": [ "Q20325", "WBGene00018344", "Q9XUK8", "WBGene00012275", "Q20325", "WBGene00018344", "Q9XUK8", "WBGene00012275" ] }, "reaction_10573117": { "compartment": "compartment_984", "id": "reaction_10573117", "reactome": "R-CEL-9690439", "name": "CYSLTR1 binds LTC4,LTD4,LTE4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10519623", "species_416372" ], "products": [ "species_10519625" ], "modifiers": [ [ "species_10573111", "inhibitor" ] ], "additional_components": [ "Q20325", "WBGene00018344", "Q9XUK8", "WBGene00012275", "species_266074", "species_266013", "CHEBI:15650", "species_266074", "species_266013", "CHEBI:15650", "Q20325", "WBGene00018344", "Q9XUK8", "WBGene00012275", "Q20325", "WBGene00018344", "Q9XUK8", "WBGene00012275" ] }, "reaction_10521905": { "compartment": "compartment_984", "id": "reaction_10521905", "reactome": "R-CEL-418918", "name": "The UDP/CysLT (P2Y17) receptor can bind UTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_417888", "species_10519635" ], "products": [ "species_10519637" ], "modifiers": [], "additional_components": [ "WBGene00016570", "H2KZ99", "WBGene00016570", "species_158602" ] }, "reaction_10521699": { "compartment": "compartment_984", "id": "reaction_10521699", "reactome": "R-CEL-417820", "name": "P2Y9 receptor can bind to LPA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10519598", "species_417891" ], "products": [ "species_10519600" ], "modifiers": [], "additional_components": [ "WBGene00016570", "species_417891", "H2KZ99", "WBGene00016570" ] }, "reaction_10521701": { "compartment": "compartment_984", "id": "reaction_10521701", "reactome": "R-CEL-417842", "name": "P2Y10 receptor can bind to LPA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_417891", "species_10519602" ], "products": [ "species_10519604" ], "modifiers": [], "additional_components": [ "WBGene00016570", "H2KZ99", "WBGene00016570", "species_417891" ] }, "reaction_10521703": { "compartment": "compartment_984", "id": "reaction_10521703", "reactome": "R-CEL-417890", "name": "P2Y5 receptor can bind to LPA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10519594", "species_417891" ], "products": [ "species_10519596" ], "modifiers": [], "additional_components": [ "WBGene00016570", "species_417891", "H2KZ99", "WBGene00016570" ] }, "reaction_10521923": { "compartment": "compartment_984", "id": "reaction_10521923", "reactome": "R-CEL-418925", "name": "ADORA2A,B bind Ade-Rib", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10521919", "species_83908" ], "products": [ "species_10521921" ], "modifiers": [], "additional_components": [ "Q10042", "WBGene00019287", "Q19295", "WBGene00019287", "Q19779", "WBGene00017779", "Q1ZXT2", "WBGene00011878", "species_83909", "Q10042", "WBGene00019287", "Q19295", "WBGene00019287", "Q19779", "WBGene00017779", "Q1ZXT2", "WBGene00011878" ] }, "reaction_10521903": { "compartment": "compartment_984", "id": "reaction_10521903", "reactome": "R-CEL-418904", "name": "A1 and A3 receptors bind adenosine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10519789", "species_83908" ], "products": [ "species_10519791" ], "modifiers": [], "additional_components": [ "Q10042", "WBGene00019287", "Q19295", "WBGene00019287", "Q19779", "WBGene00017779", "Q1ZXT2", "WBGene00011878", "species_83909", "Q10042", "WBGene00019287", "Q19295", "WBGene00019287", "Q19779", "WBGene00017779", "Q1ZXT2", "WBGene00011878" ] }, "reaction_10524681": { "compartment": "compartment_984", "id": "reaction_10524681", "reactome": "R-CEL-444731", "name": "GPR4, GPR65, GPR132 and OGR1 are pH sensing receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_10519655" ], "products": [ "species_10519659" ], "modifiers": [], "additional_components": [ "WBGene00016570", "H2KZ99", "WBGene00016570", "species_70106" ] }, "reaction_10521965": { "compartment": "compartment_984", "id": "reaction_10521965", "reactome": "R-CEL-419861", "name": "Melanospin is stimulated by light", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10519609", "species_419777" ], "products": [ "species_10519611" ], "modifiers": [], "additional_components": [ "WBGene00007006", "species_419777", "P90745", "WBGene00007006" ] }, "reaction_10520833": { "compartment": "compartment_984", "id": "reaction_10520833", "reactome": "R-CEL-390673", "name": "CHRM2,4 bind acetylcholine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10519751", "species_372533" ], "products": [ "species_10519755" ], "modifiers": [], "additional_components": [ "WBGene00001519", "species_372533", "Q9U7D5", "WBGene00001519" ] }, "reaction_10520829": { "compartment": "compartment_984", "id": "reaction_10520829", "reactome": "R-CEL-390649", "name": "CHRM1,3,5 bind acetylcholine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10519564", "species_372533" ], "products": [ "species_10519570" ], "modifiers": [], "additional_components": [ "WBGene00001519", "species_372533", "Q9U7D5", "WBGene00001519" ] }, "reaction_10572915": { "compartment": "compartment_984", "id": "reaction_10572915", "reactome": "R-CEL-9656244", "name": "DRD2 binds DA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10572911", "species_380873" ], "products": [ "species_10572913" ], "modifiers": [], "additional_components": [ "WBGene00020506", "species_351601", "Q6RYS9", "WBGene00020506" ] }, "reaction_10520835": { "compartment": "compartment_984", "id": "reaction_10520835", "reactome": "R-CEL-390846", "name": "D2D3,4 bind to DA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10519725", "species_380873" ], "products": [ "species_10519727" ], "modifiers": [], "additional_components": [ "Q6RYS9", "WBGene00020506", "E7EM37", "WBGene00001053", "G5EGH0", "WBGene00004779", "species_351601", "Q6RYS9", "WBGene00020506", "E7EM37", "WBGene00001053", "G5EGH0", "WBGene00004779" ] }, "reaction_10520837": { "compartment": "compartment_984", "id": "reaction_10520837", "reactome": "R-CEL-390886", "name": "HRH4 binds Hist", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10519710", "species_390899" ], "products": [ "species_10519712" ], "modifiers": [], "additional_components": [ "WBGene00001519", "species_390899", "Q9U7D5", "WBGene00001519" ] }, "reaction_10520846": { "compartment": "compartment_984", "id": "reaction_10520846", "reactome": "R-CEL-390909", "name": "HRH2 binds hist", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10520842", "species_390899" ], "products": [ "species_10520844" ], "modifiers": [], "additional_components": [ "WBGene00011382", "species_390899", "O45732", "WBGene00011382" ] }, "reaction_10573135": { "compartment": "compartment_984", "id": "reaction_10573135", "reactome": "R-CEL-9692880", "name": "HRH3 binds Hist", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10573131", "species_390899" ], "products": [ "species_10573133" ], "modifiers": [], "additional_components": [ "WBGene00001519", "species_390899", "Q9U7D5", "WBGene00001519" ] }, "reaction_10520848": { "compartment": "compartment_984", "id": "reaction_10520848", "reactome": "R-CEL-390929", "name": "HTR1 and 5A receptors can bind serotonin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_114523", "species_10519706" ], "products": [ "species_10519708" ], "modifiers": [], "additional_components": [ "Q7JP61", "WBGene00006411", "E7EM37", "WBGene00001053", "G5EGH0", "WBGene00004779", "Q7JP61", "WBGene00006411", "E7EM37", "WBGene00001053", "G5EGH0", "WBGene00004779", "species_380585" ] }, "reaction_10520865": { "compartment": "compartment_984", "id": "reaction_10520865", "reactome": "R-CEL-390931", "name": "5-HT4, 6 and 7 receptors can bind serotonin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10520861", "species_114523" ], "products": [ "species_10520863" ], "modifiers": [], "additional_components": [ "O45732", "WBGene00011382", "Q86ME6", "WBGene00001052", "Q22895", "WBGene00004780", "species_380585", "O45732", "WBGene00011382", "Q86ME6", "WBGene00001052", "Q22895", "WBGene00004780" ] }, "reaction_10520850": { "compartment": "compartment_984", "id": "reaction_10520850", "reactome": "R-CEL-390930", "name": "5-HT2 receptor can bind serotonin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_114523", "species_10519586" ], "products": [ "species_10519592" ], "modifiers": [], "additional_components": [ "WBGene00016037", "P91096", "WBGene00016037", "species_380585" ] }, "reaction_10573212": { "compartment": "compartment_984", "id": "reaction_10573212", "reactome": "R-CEL-9693347", "name": "HTR1A binds 5HT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_114523", "species_10573208" ], "products": [ "species_10573210" ], "modifiers": [], "additional_components": [ "WBGene00004779", "G5EGH0", "WBGene00004779", "species_380585" ] }, "reaction_10555425": { "compartment": "compartment_70101", "id": "reaction_10555425", "reactome": "R-CEL-5681981", "name": "ATG3 transfers LC3 from ATG7 to ATG3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10555420" ], "products": [ "species_10555422" ], "modifiers": [ [ "species_10555420", "catalyst" ] ], "additional_components": [ "Q9N369", "WBGene00021922", "G5EBK4", "WBGene00010882", "Q23536", "WBGene00002981", "Q09490", "WBGene00002980", "Q9N369", "WBGene00021922", "Q23536", "WBGene00002981", "Q09490", "WBGene00002980", "G5EBK4", "WBGene00010882", "Q9N369", "WBGene00021922", "G5EBK4", "WBGene00010882", "Q23536", "WBGene00002981", "Q09490", "WBGene00002980" ] }, "reaction_10555489": { "compartment": "compartment_5683628", "id": "reaction_10555489", "reactome": "R-CEL-5682388", "name": "Autophagosome maturation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10555350" ], "products": [ "species_10555480" ], "modifiers": [ [ "species_10555487", "catalyst" ], [ "species_10529080", "catalyst" ] ], "additional_components": [ "species_8959490", "Q23536", "WBGene00002981", "Q09490", "WBGene00002980", "Q23536", "WBGene00002981", "Q09490", "WBGene00002980", "species_8959490", "Q9TXI7", "WBGene00006932", "Q22592", "WBGene00000247", "Q23669", "WBGene00014151", "A7DT33", "WBGene00021319", "Q9GYK4", "WBGene00020866", "Q9BL60", "WBGene00022027", "Q9U2F6", "WBGene00012903", "O02208", "WBGene00007216", "Q22718", "WBGene00011976", "Q18886", "WBGene00016961", "Q21959", "WBGene00020025" ] }, "reaction_10554859": { "compartment": "compartment_70101", "id": "reaction_10554859", "reactome": "R-CEL-5672008", "name": "Thr-180 of ULK1 is phosphorylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10554667", "species_113592" ], "products": [ "species_29370", "species_10554856" ], "modifiers": [ [ "species_10554667", "catalyst" ] ], "additional_components": [ "species_76577", "Q9XUY2", "WBGene00010115", "P45894", "WBGene00019801", "Q95ZQ4", "WBGene00020142", "A0A1T5HUK9", "WBGene00013732", "H2L0K0", "WBGene00020135", "O02168", "WBGene00020633", "Q9N501", "WBGene00021527", "Q22342", "WBGene00020334", "Q23023", "WBGene00006786", "Q95XH2", "WBGene00022078", "P34379", "WBGene00017045", "species_76577", "Q9XUY2", "WBGene00010115", "P45894", "WBGene00019801", "Q95ZQ4", "WBGene00020142", "A0A1T5HUK9", "WBGene00013732", "H2L0K0", "WBGene00020135", "O02168", "WBGene00020633", "Q9N501", "WBGene00021527", "Q22342", "WBGene00020334", "Q23023", "WBGene00006786", "Q95XH2", "WBGene00022078", "P34379", "WBGene00017045", "species_76577", "Q9XUY2", "WBGene00010115", "P45894", "WBGene00019801", "Q95ZQ4", "WBGene00020142", "A0A1T5HUK9", "WBGene00013732", "H2L0K0", "WBGene00020135", "O02168", "WBGene00020633", "Q9N501", "WBGene00021527", "Q22342", "WBGene00020334", "Q23023", "WBGene00006786", "Q95XH2", "WBGene00022078", "P34379", "WBGene00017045" ] }, "reaction_10571498": { "compartment": "compartment_70101", "id": "reaction_10571498", "reactome": "R-CEL-9020616", "name": "ATG12 forms a thioester bond with ATG7 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10555409" ], "products": [ "species_10555535" ], "modifiers": [], "additional_components": [ "Q10931", "WBGene00002982", "G5EBK4", "WBGene00010882", "Q10931", "WBGene00002982", "G5EBK4", "WBGene00010882" ] }, "reaction_10555247": { "compartment": "compartment_74700", "id": "reaction_10555247", "reactome": "R-CEL-5675790", "name": "MTORC1 dissociates from ULK complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10555091" ], "products": [ "species_10510623", "species_10554866" ], "modifiers": [], "additional_components": [ "Q22342", "WBGene00020334", "Q23023", "WBGene00006786", "Q95XH2", "WBGene00022078", "P34379", "WBGene00017045", "P34443", "WBGene00010038", "species_29438", "Q19425", "WBGene00008774", "species_29420", "G5EGB3", "WBGene00012497", "Q22743", "WBGene00006414", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "P91040", "WBGene00015697", "Q95Q95", "WBGene00002583", "Q68TI8", "WBGene00000911", "P34443", "WBGene00010038", "species_29438", "Q19425", "WBGene00008774", "species_29420", "G5EGB3", "WBGene00012497", "Q22743", "WBGene00006414", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "P91040", "WBGene00015697", "Q95Q95", "WBGene00002583", "Q68TI8", "WBGene00000911", "Q22342", "WBGene00020334", "Q23023", "WBGene00006786", "Q95XH2", "WBGene00022078", "P34379", "WBGene00017045" ] }, "reaction_10555567": { "compartment": "compartment_70101", "id": "reaction_10555567", "reactome": "R-CEL-5683593", "name": "ATG7:ATG3:LC3 dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10555422" ], "products": [ "species_10555407", "species_10555348" ], "modifiers": [], "additional_components": [ "Q9N369", "WBGene00021922", "Q23536", "WBGene00002981", "Q09490", "WBGene00002980", "G5EBK4", "WBGene00010882", "G5EBK4", "WBGene00010882", "Q9N369", "WBGene00021922", "Q23536", "WBGene00002981", "Q09490", "WBGene00002980" ] }, "reaction_10554670": { "compartment": "compartment_70101", "id": "reaction_10554670", "reactome": "R-CEL-5665868", "name": "AMPK (complex) phosphorylates ULK1 (complex)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10554661" ], "products": [ "species_29370", "species_10554667" ], "modifiers": [ [ "species_10554661", "catalyst" ] ], "additional_components": [ "Q22342", "WBGene00020334", "Q23023", "WBGene00006786", "Q95XH2", "WBGene00022078", "P34379", "WBGene00017045", "species_76577", "Q9XUY2", "WBGene00010115", "P45894", "WBGene00019801", "Q95ZQ4", "WBGene00020142", "A0A1T5HUK9", "WBGene00013732", "H2L0K0", "WBGene00020135", "O02168", "WBGene00020633", "Q9N501", "WBGene00021527", "species_76577", "Q9XUY2", "WBGene00010115", "P45894", "WBGene00019801", "Q95ZQ4", "WBGene00020142", "A0A1T5HUK9", "WBGene00013732", "H2L0K0", "WBGene00020135", "O02168", "WBGene00020633", "Q9N501", "WBGene00021527", "Q22342", "WBGene00020334", "Q23023", "WBGene00006786", "Q95XH2", "WBGene00022078", "P34379", "WBGene00017045", "Q22342", "WBGene00020334", "Q23023", "WBGene00006786", "Q95XH2", "WBGene00022078", "P34379", "WBGene00017045", "species_76577", "Q9XUY2", "WBGene00010115", "P45894", "WBGene00019801", "Q95ZQ4", "WBGene00020142", "A0A1T5HUK9", "WBGene00013732", "H2L0K0", "WBGene00020135", "O02168", "WBGene00020633", "Q9N501", "WBGene00021527" ] }, "reaction_10555380": { "compartment": "compartment_70101", "id": "reaction_10555380", "reactome": "R-CEL-5678490", "name": "ATG16L1 complex transfers LC3 from ATG3 to PE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5681998", "species_10555348" ], "products": [ "species_10555352", "species_10555350" ], "modifiers": [ [ "species_10555377", "catalyst" ] ], "additional_components": [ "Q9N369", "WBGene00021922", "Q23536", "WBGene00002981", "Q09490", "WBGene00002980", "WBGene00021922", "species_8959490", "Q23536", "WBGene00002981", "Q09490", "WBGene00002980", "Q19124", "WBGene00017178", "Q09406", "WBGene00019427", "Q10931", "WBGene00002982", "Q3V5I7", "WBGene00022152", "O16466", "WBGene00018294", "species_5334668" ] }, "reaction_10554871": { "compartment": "compartment_17938", "id": "reaction_10554871", "reactome": "R-CEL-5672010", "name": "Active MTORC1 phosphorylates ULK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10554861", "species_113592" ], "products": [ "species_29370", "species_10554868" ], "modifiers": [ [ "species_10554861", "catalyst" ] ], "additional_components": [ "Q22342", "WBGene00020334", "Q23023", "WBGene00006786", "Q95XH2", "WBGene00022078", "P34379", "WBGene00017045", "Q19425", "WBGene00008774", "species_29420", "G5EGB3", "WBGene00012497", "Q22743", "WBGene00006414", "species_29438", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "P91040", "WBGene00015697", "Q95Q95", "WBGene00002583", "Q68TI8", "WBGene00000911", "P34443", "WBGene00010038", "Q22342", "WBGene00020334", "Q23023", "WBGene00006786", "Q95XH2", "WBGene00022078", "P34379", "WBGene00017045", "Q19425", "WBGene00008774", "species_29420", "G5EGB3", "WBGene00012497", "Q22743", "WBGene00006414", "species_29438", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "P91040", "WBGene00015697", "Q95Q95", "WBGene00002583", "Q68TI8", "WBGene00000911", "P34443", "WBGene00010038", "Q22342", "WBGene00020334", "Q23023", "WBGene00006786", "Q95XH2", "WBGene00022078", "P34379", "WBGene00017045", "Q19425", "WBGene00008774", "species_29420", "G5EGB3", "WBGene00012497", "Q22743", "WBGene00006414", "species_29438", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "P91040", "WBGene00015697", "Q95Q95", "WBGene00002583", "Q68TI8", "WBGene00000911", "P34443", "WBGene00010038" ] }, "reaction_10554873": { "compartment": "compartment_70101", "id": "reaction_10554873", "reactome": "R-CEL-5672011", "name": "p-AMPK:AMP binds the ULK complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10554659", "species_10519954" ], "products": [ "species_10554661" ], "modifiers": [], "additional_components": [ "Q22342", "WBGene00020334", "Q23023", "WBGene00006786", "Q95XH2", "WBGene00022078", "P34379", "WBGene00017045", "species_76577", "Q9XUY2", "WBGene00010115", "P45894", "WBGene00019801", "Q95ZQ4", "WBGene00020142", "A0A1T5HUK9", "WBGene00013732", "H2L0K0", "WBGene00020135", "O02168", "WBGene00020633", "Q9N501", "WBGene00021527", "Q22342", "WBGene00020334", "Q23023", "WBGene00006786", "Q95XH2", "WBGene00022078", "P34379", "WBGene00017045", "species_76577", "Q9XUY2", "WBGene00010115", "P45894", "WBGene00019801", "Q95ZQ4", "WBGene00020142", "A0A1T5HUK9", "WBGene00013732", "H2L0K0", "WBGene00020135", "O02168", "WBGene00020633", "Q9N501", "WBGene00021527" ] }, "reaction_10555259": { "compartment": "compartment_70101", "id": "reaction_10555259", "reactome": "R-CEL-5675868", "name": "ULK1 phosphorylates ATG13 and RB1CC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10554856" ], "products": [ "species_29370", "species_10555256" ], "modifiers": [ [ "species_10554856", "catalyst" ] ], "additional_components": [ "species_76577", "Q9XUY2", "WBGene00010115", "P45894", "WBGene00019801", "Q95ZQ4", "WBGene00020142", "A0A1T5HUK9", "WBGene00013732", "H2L0K0", "WBGene00020135", "O02168", "WBGene00020633", "Q9N501", "WBGene00021527", "Q22342", "WBGene00020334", "Q23023", "WBGene00006786", "Q95XH2", "WBGene00022078", "P34379", "WBGene00017045", "species_76577", "Q9XUY2", "WBGene00010115", "P45894", "WBGene00019801", "Q95ZQ4", "WBGene00020142", "A0A1T5HUK9", "WBGene00013732", "H2L0K0", "WBGene00020135", "O02168", "WBGene00020633", "Q9N501", "WBGene00021527", "P34379", "WBGene00017045", "Q23023", "WBGene00006786", "Q22342", "WBGene00020334", "Q95XH2", "WBGene00022078", "species_76577", "Q9XUY2", "WBGene00010115", "P45894", "WBGene00019801", "Q95ZQ4", "WBGene00020142", "A0A1T5HUK9", "WBGene00013732", "H2L0K0", "WBGene00020135", "O02168", "WBGene00020633", "Q9N501", "WBGene00021527", "Q22342", "WBGene00020334", "Q23023", "WBGene00006786", "Q95XH2", "WBGene00022078", "P34379", "WBGene00017045" ] }, "reaction_10555452": { "compartment": "compartment_70101", "id": "reaction_10555452", "reactome": "R-CEL-5681987", "name": "LC3 is cleaved by ATG4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10555433" ], "products": [ "species_10555340" ], "modifiers": [ [ "species_10555449", "catalyst" ] ], "additional_components": [ "Q23536", "WBGene00002981", "Q09490", "WBGene00002980", "Q23536", "WBGene00002981", "Q09490", "WBGene00002980", "K8ESC5", "WBGene00013595" ] }, "reaction_10555454": { "compartment": "compartment_70101", "id": "reaction_10555454", "reactome": "R-CEL-5682011", "name": "LC3 binds ATG7 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10555407", "species_10555340" ], "products": [ "species_10555418" ], "modifiers": [], "additional_components": [ "G5EBK4", "WBGene00010882", "Q23536", "WBGene00002981", "Q09490", "WBGene00002980", "G5EBK4", "WBGene00010882", "Q23536", "WBGene00002981", "Q09490", "WBGene00002980" ] }, "reaction_10555456": { "compartment": "compartment_70101", "id": "reaction_10555456", "reactome": "R-CEL-5682377", "name": "LC3 de-lipidation by ATG4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10555350" ], "products": [ "species_10555340", "species_5681998" ], "modifiers": [ [ "species_10555449", "catalyst" ] ], "additional_components": [ "species_8959490", "Q23536", "WBGene00002981", "Q09490", "WBGene00002980", "Q23536", "WBGene00002981", "Q09490", "WBGene00002980", "K8ESC5", "WBGene00013595" ] }, "reaction_10536642": { "compartment": "compartment_70101", "id": "reaction_10536642", "reactome": "R-CEL-1632857", "name": "ULK1 phosphorylates AMBRA1:BECN1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10536602", "species_113592" ], "products": [ "species_29370", "species_10536608" ], "modifiers": [ [ "species_10536639", "catalyst" ] ], "additional_components": [ "Q9XWQ4", "WBGene00013695", "Q9TXI7", "WBGene00006932", "Q22592", "WBGene00000247", "Q23669", "WBGene00014151", "Q65XS9", "WBGene00043067", "A0AAC1", "WBGene00012424", "Q7YTJ8", "WBGene00012425", "Q21557", "WBGene00010888", "Q22799", "WBGene00001005", "Q9XWQ4", "WBGene00013695", "Q9TXI7", "WBGene00006932", "Q22592", "WBGene00000247", "Q23669", "WBGene00014151", "Q65XS9", "WBGene00043067", "A0AAC1", "WBGene00012424", "Q7YTJ8", "WBGene00012425", "Q21557", "WBGene00010888", "Q22799", "WBGene00001005", "species_76577", "Q9XUY2", "WBGene00010115", "P45894", "WBGene00019801", "Q95ZQ4", "WBGene00020142", "A0A1T5HUK9", "WBGene00013732", "H2L0K0", "WBGene00020135", "O02168", "WBGene00020633", "Q9N501", "WBGene00021527", "Q22342", "WBGene00020334", "Q95XH2", "WBGene00022078", "P34379", "WBGene00017045", "Q23023", "WBGene00006786" ] }, "reaction_10554883": { "compartment": "compartment_12045", "id": "reaction_10554883", "reactome": "R-CEL-5672012", "name": "Beclin-1 complex phosphorylates PtdIns", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_426639" ], "products": [ "species_29370", "species_5676030" ], "modifiers": [ [ "species_10554880", "catalyst" ] ], "additional_components": [ "Q9TXI7", "WBGene00006932", "Q23669", "WBGene00014151", "Q9XWQ4", "WBGene00013695", "Q22592", "WBGene00000247" ] }, "reaction_10555396": { "compartment": "compartment_70101", "id": "reaction_10555396", "reactome": "R-CEL-5679205", "name": "ULK1 phosphorylates Beclin-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10555394" ], "products": [ "species_29370", "species_10554880" ], "modifiers": [ [ "species_10536639", "catalyst" ] ], "additional_components": [ "Q9TXI7", "WBGene00006932", "Q22592", "WBGene00000247", "Q23669", "WBGene00014151", "Q9XWQ4", "WBGene00013695", "Q9TXI7", "WBGene00006932", "Q23669", "WBGene00014151", "Q9XWQ4", "WBGene00013695", "Q22592", "WBGene00000247", "species_76577", "Q9XUY2", "WBGene00010115", "P45894", "WBGene00019801", "Q95ZQ4", "WBGene00020142", "A0A1T5HUK9", "WBGene00013732", "H2L0K0", "WBGene00020135", "O02168", "WBGene00020633", "Q9N501", "WBGene00021527", "Q22342", "WBGene00020334", "Q95XH2", "WBGene00022078", "P34379", "WBGene00017045", "Q23023", "WBGene00006786" ] }, "reaction_10554887": { "compartment": "compartment_17938", "id": "reaction_10554887", "reactome": "R-CEL-5672017", "name": "Rheb in the MTORC1 complex hydrolyses GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10510588" ], "products": [ "species_10519963" ], "modifiers": [ [ "species_10510588", "catalyst" ] ], "additional_components": [ "Q19425", "WBGene00008774", "species_29420", "G5EGB3", "WBGene00012497", "Q22743", "WBGene00006414", "species_29438", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "P91040", "WBGene00015697", "Q95Q95", "WBGene00002583", "Q68TI8", "WBGene00000911", "P34443", "WBGene00010038", "P34443", "WBGene00010038", "species_29420", "Q19425", "WBGene00008774", "G5EGB3", "WBGene00012497", "Q22743", "WBGene00006414", "species_29438", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "P91040", "WBGene00015697", "Q95Q95", "WBGene00002583", "Q68TI8", "WBGene00000911", "Q19425", "WBGene00008774", "species_29420", "G5EGB3", "WBGene00012497", "Q22743", "WBGene00006414", "species_29438", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "P91040", "WBGene00015697", "Q95Q95", "WBGene00002583", "Q68TI8", "WBGene00000911", "P34443", "WBGene00010038" ] }, "reaction_10555399": { "compartment": "compartment_70101", "id": "reaction_10555399", "reactome": "R-CEL-5679206", "name": "MTMR14, MTMR3 dephosphorylate PI3P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5676030" ], "products": [ "species_426639" ], "modifiers": [ [ "species_10537226", "catalyst" ] ], "additional_components": [ "WBGene00003476" ] }, "reaction_10555401": { "compartment": "compartment_70101", "id": "reaction_10555401", "reactome": "R-CEL-5679239", "name": "ULK complex translocates to the ER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10555256" ], "products": [ "species_10536639" ], "modifiers": [], "additional_components": [ "species_76577", "Q9XUY2", "WBGene00010115", "P45894", "WBGene00019801", "Q95ZQ4", "WBGene00020142", "A0A1T5HUK9", "WBGene00013732", "H2L0K0", "WBGene00020135", "O02168", "WBGene00020633", "Q9N501", "WBGene00021527", "P34379", "WBGene00017045", "Q23023", "WBGene00006786", "Q22342", "WBGene00020334", "Q95XH2", "WBGene00022078", "species_76577", "Q9XUY2", "WBGene00010115", "P45894", "WBGene00019801", "Q95ZQ4", "WBGene00020142", "A0A1T5HUK9", "WBGene00013732", "H2L0K0", "WBGene00020135", "O02168", "WBGene00020633", "Q9N501", "WBGene00021527", "Q22342", "WBGene00020334", "Q95XH2", "WBGene00022078", "P34379", "WBGene00017045", "Q23023", "WBGene00006786" ] }, "reaction_10554891": { "compartment": "compartment_70101", "id": "reaction_10554891", "reactome": "R-CEL-5672817", "name": "Active MTORC1 binds the ULK1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10510588", "species_10554659" ], "products": [ "species_10554861" ], "modifiers": [], "additional_components": [ "Q19425", "WBGene00008774", "species_29420", "G5EGB3", "WBGene00012497", "Q22743", "WBGene00006414", "species_29438", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "P91040", "WBGene00015697", "Q95Q95", "WBGene00002583", "Q68TI8", "WBGene00000911", "P34443", "WBGene00010038", "Q22342", "WBGene00020334", "Q23023", "WBGene00006786", "Q95XH2", "WBGene00022078", "P34379", "WBGene00017045", "Q22342", "WBGene00020334", "Q23023", "WBGene00006786", "Q95XH2", "WBGene00022078", "P34379", "WBGene00017045", "Q19425", "WBGene00008774", "species_29420", "G5EGB3", "WBGene00012497", "Q22743", "WBGene00006414", "species_29438", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "P91040", "WBGene00015697", "Q95Q95", "WBGene00002583", "Q68TI8", "WBGene00000911", "P34443", "WBGene00010038" ] }, "reaction_10555403": { "compartment": "compartment_70101", "id": "reaction_10555403", "reactome": "R-CEL-5679255", "name": "WIPI2 binds ATG12:ATG5:ATG16L", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10555375", "species_10555373" ], "products": [ "species_10555377" ], "modifiers": [], "additional_components": [ "O16466", "WBGene00018294", "species_5334668", "Q19124", "WBGene00017178", "Q09406", "WBGene00019427", "Q10931", "WBGene00002982", "Q3V5I7", "WBGene00022152", "Q19124", "WBGene00017178", "Q09406", "WBGene00019427", "Q10931", "WBGene00002982", "Q3V5I7", "WBGene00022152", "O16466", "WBGene00018294", "species_5334668" ] }, "reaction_10555405": { "compartment": "compartment_70101", "id": "reaction_10555405", "reactome": "R-CEL-5679266", "name": "Beclin-1 complex translocates to the ER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10536600" ], "products": [ "species_10555394" ], "modifiers": [], "additional_components": [ "Q9XWQ4", "WBGene00013695", "Q9TXI7", "WBGene00006932", "Q22592", "WBGene00000247", "Q23669", "WBGene00014151", "Q9TXI7", "WBGene00006932", "Q22592", "WBGene00000247", "Q23669", "WBGene00014151", "Q9XWQ4", "WBGene00013695" ] }, "reaction_10555469": { "compartment": "compartment_12045", "id": "reaction_10555469", "reactome": "R-CEL-5682385", "name": "The phagophore extends from the PIP3-enriched structure", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10554880" ], "products": [ "species_10555460" ], "modifiers": [ [ "species_10555465", "catalyst" ] ], "additional_components": [ "Q9TXI7", "WBGene00006932", "Q23669", "WBGene00014151", "Q9XWQ4", "WBGene00013695", "Q22592", "WBGene00000247", "Q9XWQ4", "WBGene00013695", "Q9TXI7", "WBGene00006932", "Q23669", "WBGene00014151", "Q22592", "WBGene00000247", "WBGene00020706" ] }, "reaction_10555598": { "compartment": "compartment_70101", "id": "reaction_10555598", "reactome": "R-CEL-5683925", "name": "ULK1 is dephosphorylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10554866" ], "products": [ "species_29372", "species_10554659" ], "modifiers": [], "additional_components": [ "Q22342", "WBGene00020334", "Q23023", "WBGene00006786", "Q95XH2", "WBGene00022078", "P34379", "WBGene00017045", "Q22342", "WBGene00020334", "Q23023", "WBGene00006786", "Q95XH2", "WBGene00022078", "P34379", "WBGene00017045" ] }, "reaction_10555537": { "compartment": "compartment_70101", "id": "reaction_10555537", "reactome": "R-CEL-5682896", "name": "LC3:ATG7 dimer binds ATG3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10555418", "species_10555352" ], "products": [ "species_10555420" ], "modifiers": [], "additional_components": [ "G5EBK4", "WBGene00010882", "Q23536", "WBGene00002981", "Q09490", "WBGene00002980", "WBGene00021922", "Q9N369", "WBGene00021922", "G5EBK4", "WBGene00010882", "Q23536", "WBGene00002981", "Q09490", "WBGene00002980" ] }, "reaction_10555411": { "compartment": "compartment_70101", "id": "reaction_10555411", "reactome": "R-CEL-5681980", "name": "ATG12 binds ATG7 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10555407", "species_10555366" ], "products": [ "species_10555409" ], "modifiers": [], "additional_components": [ "G5EBK4", "WBGene00010882", "WBGene00002982", "Q10931", "WBGene00002982", "G5EBK4", "WBGene00010882" ] }, "reaction_10555093": { "compartment": "compartment_70101", "id": "reaction_10555093", "reactome": "R-CEL-5673768", "name": "p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10554868" ], "products": [ "species_29370", "species_10555091" ], "modifiers": [ [ "species_10519954", "catalyst" ] ], "additional_components": [ "Q22342", "WBGene00020334", "Q23023", "WBGene00006786", "Q95XH2", "WBGene00022078", "P34379", "WBGene00017045", "Q19425", "WBGene00008774", "species_29420", "G5EGB3", "WBGene00012497", "Q22743", "WBGene00006414", "species_29438", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "P91040", "WBGene00015697", "Q95Q95", "WBGene00002583", "Q68TI8", "WBGene00000911", "P34443", "WBGene00010038", "Q22342", "WBGene00020334", "Q23023", "WBGene00006786", "Q95XH2", "WBGene00022078", "P34379", "WBGene00017045", "P34443", "WBGene00010038", "species_29438", "Q19425", "WBGene00008774", "species_29420", "G5EGB3", "WBGene00012497", "Q22743", "WBGene00006414", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "P91040", "WBGene00015697", "Q95Q95", "WBGene00002583", "Q68TI8", "WBGene00000911", "species_76577", "Q9XUY2", "WBGene00010115", "P45894", "WBGene00019801", "Q95ZQ4", "WBGene00020142", "A0A1T5HUK9", "WBGene00013732", "H2L0K0", "WBGene00020135", "O02168", "WBGene00020633", "Q9N501", "WBGene00021527" ] }, "reaction_10555284": { "compartment": "compartment_70101", "id": "reaction_10555284", "reactome": "R-CEL-5676229", "name": "WIPIs bind PI3P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5693050", "species_10555280" ], "products": [ "species_10555282" ], "modifiers": [], "additional_components": [ "O16466", "WBGene00018294", "O16466", "WBGene00018294", "species_1806200" ] }, "reaction_10563248": { "compartment": "compartment_6791047", "id": "reaction_10563248", "reactome": "R-CEL-6807872", "name": "Active ARF recruits coatomer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10563199", "species_10563244" ], "products": [ "species_10563246" ], "modifiers": [], "additional_components": [ "G5EGG0", "WBGene00010713", "Q9UAQ6", "WBGene00004266", "species_29438", "G5EGS5", "WBGene00007703", "Q94231", "WBGene00000190", "Q09236", "WBGene00015734", "Q22498", "WBGene00011775", "Q9TYL9", "WBGene00021292", "O17901", "WBGene00010333", "Q20168", "WBGene00009542", "O62246", "WBGene00009732", "Q9N4H7", "WBGene00022119", "Q09236", "WBGene00015734", "Q22498", "WBGene00011775", "Q9TYL9", "WBGene00021292", "O17901", "WBGene00010333", "Q20168", "WBGene00009542", "O62246", "WBGene00009732", "Q9N4H7", "WBGene00022119", "G5EGG0", "WBGene00010713", "Q9UAQ6", "WBGene00004266", "species_29438", "G5EGS5", "WBGene00007703", "Q94231", "WBGene00000190" ] }, "reaction_10563616": { "compartment": "compartment_20699", "id": "reaction_10563616", "reactome": "R-CEL-6809011", "name": "cis-Golgi t-SNAREs bind YKT6 on tethered vesicle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10563612", "species_10563597" ], "products": [ "species_10563614" ], "modifiers": [], "additional_components": [ "Q95ZW1", "WBGene00017273", "P41941", "WBGene00007128", "Q20797", "WBGene00006373", "G5EEU1", "WBGene00043064", "Q9N3Y1", "WBGene00021536", "Q19989", "WBGene00018017", "Q9TXZ9", "WBGene00015164", "Q18849", "WBGene00009500", "Q22328", "WBGene00002976", "A0A1N7SYP5", "WBGene00009500", "P48583", "WBGene00001331", "Q09473", "WBGene00016195", "G5EEU1", "WBGene00043064", "G5EGG0", "WBGene00010713", "Q9UAQ6", "WBGene00004266", "species_29438", "Q9N4H7", "WBGene00022119", "Q20168", "WBGene00009542", "O62246", "WBGene00009732", "Q22498", "WBGene00011775", "O17901", "WBGene00010333", "Q09236", "WBGene00015734", "Q9TYL9", "WBGene00021292", "O44738", "WBGene00019003", "Q20546", "WBGene00009829", "A4F319", "WBGene00011606", "Q9U1Z4", "WBGene00013360", "O17528", "WBGene00004766", "E0AHA7", "WBGene00006803", "G5EFW3", "WBGene00004855", "Q21408", "WBGene00004951", "Q21270", "WBGene00019481", "Q6AW08", "WBGene00022121", "Q95XZ0", "WBGene00021784", "G5EE66", "WBGene00003258", "O44502", "WBGene00019820", "Q21444", "WBGene00000585", "P91151", "WBGene00016608", "Q9U3K1", "WBGene00008687", "Q9N3Y1", "WBGene00021536", "Q19989", "WBGene00018017", "Q9TXZ9", "WBGene00015164", "Q18849", "WBGene00009500", "Q22328", "WBGene00002976", "A0A1N7SYP5", "WBGene00009500", "P48583", "WBGene00001331", "Q09473", "WBGene00016195", "G5EEU1", "WBGene00043064", "G5EGG0", "WBGene00010713", "Q9UAQ6", "WBGene00004266", "species_29438", "Q9N4H7", "WBGene00022119", "Q20168", "WBGene00009542", "O62246", "WBGene00009732", "Q22498", "WBGene00011775", "O17901", "WBGene00010333", "Q09236", "WBGene00015734", "Q9TYL9", "WBGene00021292", "O44738", "WBGene00019003", "Q20546", "WBGene00009829", "A4F319", "WBGene00011606", "Q9U1Z4", "WBGene00013360", "O17528", "WBGene00004766", "E0AHA7", "WBGene00006803", "G5EFW3", "WBGene00004855", "Q21408", "WBGene00004951", "Q21270", "WBGene00019481", "Q6AW08", "WBGene00022121", "Q95XZ0", "WBGene00021784", "G5EE66", "WBGene00003258", "O44502", "WBGene00019820", "Q21444", "WBGene00000585", "P91151", "WBGene00016608", "Q9U3K1", "WBGene00008687", "Q95ZW1", "WBGene00017273", "P41941", "WBGene00007128", "Q20797", "WBGene00006373" ] }, "reaction_10563202": { "compartment": "compartment_6791047", "id": "reaction_10563202", "reactome": "R-CEL-6807868", "name": "GBF1 stimulates ARF nucleotide exchange", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10563193" ], "products": [ "species_10563199", "species_29370" ], "modifiers": [ [ "species_10563193", "catalyst" ] ], "additional_components": [ "Q94231", "WBGene00000190", "species_29420", "G5EGG0", "WBGene00010713", "Q9UAQ6", "WBGene00004266", "species_29438", "G5EGS5", "WBGene00007703", "G5EGG0", "WBGene00010713", "Q9UAQ6", "WBGene00004266", "species_29438", "G5EGS5", "WBGene00007703", "Q94231", "WBGene00000190", "Q94231", "WBGene00000190", "species_29420", "G5EGG0", "WBGene00010713", "Q9UAQ6", "WBGene00004266", "species_29438", "G5EGS5", "WBGene00007703" ] }, "reaction_10563622": { "compartment": "compartment_20699", "id": "reaction_10563622", "reactome": "R-CEL-6809014", "name": "cis-Golgi cis-SNARE binds NSF and SNAPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10563618", "species_10557345", "species_10557329" ], "products": [ "species_10563620" ], "modifiers": [], "additional_components": [ "Q9TXZ9", "WBGene00015164", "Q95ZW1", "WBGene00017273", "P41941", "WBGene00007128", "Q20797", "WBGene00006373", "G5EEU1", "WBGene00043064", "Q18921", "WBGene00017016", "Q94392", "WBGene00003818", "Q18921", "WBGene00017016", "Q94392", "WBGene00003818", "Q9TXZ9", "WBGene00015164", "Q95ZW1", "WBGene00017273", "P41941", "WBGene00007128", "Q20797", "WBGene00006373", "G5EEU1", "WBGene00043064" ] }, "reaction_10563195": { "compartment": "compartment_6791047", "id": "reaction_10563195", "reactome": "R-CEL-6807866", "name": "GBF1 recruits ARF:GDP to the ERGIC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10563181", "species_10563191" ], "products": [ "species_10563193" ], "modifiers": [], "additional_components": [ "G5EGG0", "WBGene00010713", "Q9UAQ6", "WBGene00004266", "species_29438", "G5EGS5", "WBGene00007703", "Q94231", "WBGene00000190", "species_29420", "Q94231", "WBGene00000190", "species_29420", "G5EGG0", "WBGene00010713", "Q9UAQ6", "WBGene00004266", "species_29438", "G5EGS5", "WBGene00007703" ] }, "reaction_10563419": { "compartment": "compartment_6791047", "id": "reaction_10563419", "reactome": "R-CEL-6807877", "name": "ARFGAPs stimulate ARF GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10563328" ], "products": [ "species_10563262", "species_10563179", "species_10563416", "species_10563191" ], "modifiers": [ [ "species_10563328", "catalyst" ] ], "additional_components": [ "Q9TXZ9", "WBGene00015164", "Q20546", "WBGene00009829", "O17528", "WBGene00004766", "A4F319", "WBGene00011606", "Q9U1Z4", "WBGene00013360", "O44738", "WBGene00019003", "Q22328", "WBGene00002976", "A0A1N7SYP5", "WBGene00009500", "Q18849", "WBGene00009500", "P48583", "WBGene00001331", "Q09473", "WBGene00016195", "G5EEU1", "WBGene00043064", "E0AHA7", "WBGene00006803", "G5EFW3", "WBGene00004855", "Q21408", "WBGene00004951", "Q09236", "WBGene00015734", "Q22498", "WBGene00011775", "Q9TYL9", "WBGene00021292", "O17901", "WBGene00010333", "Q20168", "WBGene00009542", "O62246", "WBGene00009732", "Q9N4H7", "WBGene00022119", "G5EGG0", "WBGene00010713", "Q9UAQ6", "WBGene00004266", "species_29438", "G5EGS5", "WBGene00007703", "Q94231", "WBGene00000190", "Q09531", "WBGene00017217", "P90904", "WBGene00010500", "Q09531", "WBGene00017217", "P90904", "WBGene00010500", "WBGene00007703", "Q9UAQ6", "WBGene00004266", "species_29438", "G5EGG0", "WBGene00010713", "Q09236", "WBGene00015734", "Q9TYL9", "WBGene00021292", "Q22498", "WBGene00011775", "O17901", "WBGene00010333", "Q9N4H7", "WBGene00022119", "Q20168", "WBGene00009542", "O62246", "WBGene00009732", "Q20546", "WBGene00009829", "Q9U1Z4", "WBGene00013360", "A4F319", "WBGene00011606", "O17528", "WBGene00004766", "O44738", "WBGene00019003", "P48583", "WBGene00001331", "Q09473", "WBGene00016195", "A0A1N7SYP5", "WBGene00009500", "Q18849", "WBGene00009500", "Q22328", "WBGene00002976", "G5EEU1", "WBGene00043064", "Q9TXZ9", "WBGene00015164", "E0AHA7", "WBGene00006803", "G5EFW3", "WBGene00004855", "Q21408", "WBGene00004951", "Q94231", "WBGene00000190", "species_29420", "Q9TXZ9", "WBGene00015164", "Q20546", "WBGene00009829", "O17528", "WBGene00004766", "A4F319", "WBGene00011606", "Q9U1Z4", "WBGene00013360", "O44738", "WBGene00019003", "Q22328", "WBGene00002976", "A0A1N7SYP5", "WBGene00009500", "Q18849", "WBGene00009500", "P48583", "WBGene00001331", "Q09473", "WBGene00016195", "G5EEU1", "WBGene00043064", "E0AHA7", "WBGene00006803", "G5EFW3", "WBGene00004855", "Q21408", "WBGene00004951", "Q09236", "WBGene00015734", "Q22498", "WBGene00011775", "Q9TYL9", "WBGene00021292", "O17901", "WBGene00010333", "Q20168", "WBGene00009542", "O62246", "WBGene00009732", "Q9N4H7", "WBGene00022119", "G5EGG0", "WBGene00010713", "Q9UAQ6", "WBGene00004266", "species_29438", "G5EGS5", "WBGene00007703", "Q94231", "WBGene00000190", "Q09531", "WBGene00017217", "P90904", "WBGene00010500" ] }, "reaction_10563453": { "compartment": "compartment_432051", "id": "reaction_10563453", "reactome": "R-CEL-6809003", "name": "ERGIC-to-Golgi vesicles bind dynein:dynactin ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10563416", "species_10553033" ], "products": [ "species_10563451" ], "modifiers": [], "additional_components": [ "Q9UAQ6", "WBGene00004266", "species_29438", "G5EGG0", "WBGene00010713", "Q09236", "WBGene00015734", "Q9TYL9", "WBGene00021292", "Q22498", "WBGene00011775", "O17901", "WBGene00010333", "Q9N4H7", "WBGene00022119", "Q20168", "WBGene00009542", "O62246", "WBGene00009732", "Q20546", "WBGene00009829", "Q9U1Z4", "WBGene00013360", "A4F319", "WBGene00011606", "O17528", "WBGene00004766", "O44738", "WBGene00019003", "P48583", "WBGene00001331", "Q09473", "WBGene00016195", "A0A1N7SYP5", "WBGene00009500", "Q18849", "WBGene00009500", "Q22328", "WBGene00002976", "G5EEU1", "WBGene00043064", "Q9TXZ9", "WBGene00015164", "E0AHA7", "WBGene00006803", "G5EFW3", "WBGene00004855", "Q21408", "WBGene00004951", "Q19020", "WBGene00000962", "O45087", "WBGene00015927", "Q65XS9", "WBGene00043067", "A0AAC1", "WBGene00012424", "Q7YTJ8", "WBGene00012425", "Q21557", "WBGene00010888", "Q22799", "WBGene00001005", "G5ED34", "WBGene00001007", "species_29420", "species_29438", "Q9NA98", "WBGene00013168", "P34685", "WBGene00000292", "P34686", "WBGene00000293", "Q18194", "WBGene00016124", "Q9N4I1", "WBGene00022118", "Q9N3F1", "WBGene00021827", "Q9GYR2", "WBGene00016793", "Q09248", "WBGene00001018", "E2JKZ0", "WBGene00001017", "Q19020", "WBGene00000962", "O45087", "WBGene00015927", "Q65XS9", "WBGene00043067", "A0AAC1", "WBGene00012424", "Q7YTJ8", "WBGene00012425", "Q21557", "WBGene00010888", "Q22799", "WBGene00001005", "G5ED34", "WBGene00001007", "species_29420", "species_29438", "Q9NA98", "WBGene00013168", "P34685", "WBGene00000292", "P34686", "WBGene00000293", "Q18194", "WBGene00016124", "Q9N4I1", "WBGene00022118", "Q9N3F1", "WBGene00021827", "Q9GYR2", "WBGene00016793", "Q09248", "WBGene00001018", "E2JKZ0", "WBGene00001017", "Q9UAQ6", "WBGene00004266", "G5EGG0", "WBGene00010713", "Q09236", "WBGene00015734", "Q9TYL9", "WBGene00021292", "Q22498", "WBGene00011775", "O17901", "WBGene00010333", "Q9N4H7", "WBGene00022119", "Q20168", "WBGene00009542", "O62246", "WBGene00009732", "Q20546", "WBGene00009829", "Q9U1Z4", "WBGene00013360", "A4F319", "WBGene00011606", "O17528", "WBGene00004766", "O44738", "WBGene00019003", "P48583", "WBGene00001331", "Q09473", "WBGene00016195", "A0A1N7SYP5", "WBGene00009500", "Q18849", "WBGene00009500", "Q22328", "WBGene00002976", "G5EEU1", "WBGene00043064", "Q9TXZ9", "WBGene00015164", "E0AHA7", "WBGene00006803", "G5EFW3", "WBGene00004855", "Q21408", "WBGene00004951" ] }, "reaction_10563183": { "compartment": "compartment_6791047", "id": "reaction_10563183", "reactome": "R-CEL-6807864", "name": "RAB1:GTP recruits GBF1 to the ERGIC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10563179", "species_10563177", "species_10557302" ], "products": [ "species_10563181" ], "modifiers": [], "additional_components": [ "WBGene00007703", "Q9UAQ6", "WBGene00004266", "species_29438", "G5EGG0", "WBGene00010713", "G5EGG0", "WBGene00010713", "Q9UAQ6", "WBGene00004266", "species_29438", "G5EGS5", "WBGene00007703" ] }, "reaction_10524156": { "compartment": "compartment_17906", "id": "reaction_10524156", "reactome": "R-CEL-434382", "name": "ACSL3,4 ligates coenzyme A (CoA-SH) to palmitate yielding palmitoyl-coenzyme A in the pancreatic beta cell", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_3632881", "species_76194" ], "products": [ "species_1132084", "species_200993", "species_76577" ], "modifiers": [ [ "species_10524153", "catalyst" ] ], "additional_components": [ "A0A4V0ING4", "WBGene00016716", "Q20121", "WBGene00018152" ] }, "reaction_10559061": { "compartment": "compartment_7660", "id": "reaction_10559061", "reactome": "R-CEL-6791227", "name": "47S pre-rRNA is nucleolytically processed at A' (01,A1), site A0, and site 02 (site 6) to yield 45S pre-rRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10559047" ], "products": [ "species_10559051" ], "modifiers": [ [ "species_10559056", "catalyst" ], [ "species_10558582", "catalyst" ], [ "species_10559059", "catalyst" ], [ "species_10558737", "catalyst" ], [ "species_10558715", "catalyst" ], [ "species_10558761", "catalyst" ] ], "additional_components": [ "Q9XX15", "WBGene00012652", "Q22053", "WBGene00001423", "Q21568", "WBGene00010896", "O45012", "WBGene00020915", "Q21276", "WBGene00010627", "A9D0C6", "WBGene00020171", "O16311", "WBGene00015461", "Q95XY4", "WBGene00021789", "Q8MNX1", "WBGene00020705", "Q23314", "WBGene00013892", "Q21736", "WBGene00011032", "P34580", "WBGene00012059", "Q9N3Q9", "WBGene00021660", "Q22046", "WBGene00011311", "Q18038", "WBGene00002850", "Q23494", "WBGene00022742", "Q19873", "WBGene00009211", "A7DT40", "WBGene00045433", "Q9N477", "WBGene00021276", "Q9XUU8", "WBGene00010582", "Q23495", "WBGene00022739", "P51403", "WBGene00004471", "Q09462", "WBGene00007623", "Q9NEN6", "WBGene00004475", "Q9N306", "WBGene00022021", "Q23400", "WBGene00022852", "Q23312", "WBGene00004476", "Q20228", "WBGene00004478", "P48150", "WBGene00004483", "P41843", "WBGene00020601", "Q19545", "WBGene00007050", "Q93638", "WBGene00009266", "P91280", "WBGene00017855", "Q9U2I4", "WBGene00012756", "O01513", "WBGene00016740", "O62518", "WBGene00014083", "Q9XW58", "WBGene00013544", "Q2WF63", "WBGene00019219", "P42000", "WBGene00015104", "P91341", "WBGene00018891", "Q19433", "WBGene00017435", "O62477", "WBGene00012887", "O18215", "WBGene00013143", "P34305", "WBGene00015525", "Q9XX15", "WBGene00012652", "Q22053", "WBGene00001423", "Q21568", "WBGene00010896", "O45012", "WBGene00020915", "Q21276", "WBGene00010627", "A9D0C6", "WBGene00020171", "O16311", "WBGene00015461", "Q95XY4", "WBGene00021789", "Q8MNX1", "WBGene00020705", "Q23314", "WBGene00013892", "Q21736", "WBGene00011032", "P34580", "WBGene00012059", "Q9N3Q9", "WBGene00021660", "Q22046", "WBGene00011311", "Q18038", "WBGene00002850", "Q23494", "WBGene00022742", "Q19873", "WBGene00009211", "A7DT40", "WBGene00045433", "Q9N477", "WBGene00021276", "Q9XUU8", "WBGene00010582", "Q23495", "WBGene00022739", "P51403", "WBGene00004471", "Q09462", "WBGene00007623", "Q9NEN6", "WBGene00004475", "Q9N306", "WBGene00022021", "Q23400", "WBGene00022852", "Q23312", "WBGene00004476", "Q20228", "WBGene00004478", "P48150", "WBGene00004483", "P41843", "WBGene00020601", "Q19545", "WBGene00007050", "Q93638", "WBGene00009266", "P91280", "WBGene00017855", "Q9U2I4", "WBGene00012756", "O01513", "WBGene00016740", "O62518", "WBGene00014083", "Q9XW58", "WBGene00013544", "Q2WF63", "WBGene00019219", "P42000", "WBGene00015104", "P91341", "WBGene00018891", "Q19433", "WBGene00017435", "O62477", "WBGene00012887", "O18215", "WBGene00013143", "P34305", "WBGene00015525", "WBGene00006964", "WBGene00012342", "WBGene00004705", "WBGene00015104", "A7DT40", "WBGene00045433", "Q9N477", "WBGene00021276", "Q9XUU8", "WBGene00010582", "Q23495", "WBGene00022739", "Q95XY4", "WBGene00021789", "Q8MNX1", "WBGene00020705", "Q23314", "WBGene00013892" ] }, "reaction_10558907": { "compartment": "compartment_7660", "id": "reaction_10558907", "reactome": "R-CEL-6791222", "name": "21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10558872" ], "products": [ "species_10558880" ], "modifiers": [ [ "species_10558904", "catalyst" ], [ "species_10558594", "catalyst" ], [ "species_10558892", "catalyst" ], [ "species_10558582", "catalyst" ] ], "additional_components": [ "Q9XX15", "WBGene00012652", "Q22053", "WBGene00001423", "Q21568", "WBGene00010896", "O45012", "WBGene00020915", "Q21276", "WBGene00010627", "A9D0C6", "WBGene00020171", "O16311", "WBGene00015461", "Q95XY4", "WBGene00021789", "Q8MNX1", "WBGene00020705", "Q23314", "WBGene00013892", "Q21736", "WBGene00011032", "P34580", "WBGene00012059", "Q9N3Q9", "WBGene00021660", "Q22046", "WBGene00011311", "Q18038", "WBGene00002850", "Q23494", "WBGene00022742", "Q19873", "WBGene00009211", "A7DT40", "WBGene00045433", "Q9N477", "WBGene00021276", "Q9XUU8", "WBGene00010582", "Q23495", "WBGene00022739", "P51403", "WBGene00004471", "Q09462", "WBGene00007623", "Q9NEN6", "WBGene00004475", "Q9N306", "WBGene00022021", "Q23400", "WBGene00022852", "Q23312", "WBGene00004476", "Q20228", "WBGene00004478", "P48150", "WBGene00004483", "P41843", "WBGene00020601", "Q19545", "WBGene00007050", "Q93638", "WBGene00009266", "P91280", "WBGene00017855", "Q9U2I4", "WBGene00012756", "O01513", "WBGene00016740", "O62518", "WBGene00014083", "Q9XW58", "WBGene00013544", "Q2WF63", "WBGene00019219", "P42000", "WBGene00015104", "P91341", "WBGene00018891", "Q19433", "WBGene00017435", "O62477", "WBGene00012887", "O18215", "WBGene00013143", "P34305", "WBGene00015525", "Q9XX15", "WBGene00012652", "Q22053", "WBGene00001423", "Q21568", "WBGene00010896", "O45012", "WBGene00020915", "Q21276", "WBGene00010627", "A9D0C6", "WBGene00020171", "O16311", "WBGene00015461", "Q95XY4", "WBGene00021789", "Q8MNX1", "WBGene00020705", "Q23314", "WBGene00013892", "Q21736", "WBGene00011032", "P34580", "WBGene00012059", "Q9N3Q9", "WBGene00021660", "Q22046", "WBGene00011311", "Q18038", "WBGene00002850", "Q23494", "WBGene00022742", "Q19873", "WBGene00009211", "A7DT40", "WBGene00045433", "Q9N477", "WBGene00021276", "Q9XUU8", "WBGene00010582", "Q23495", "WBGene00022739", "P51403", "WBGene00004471", "Q09462", "WBGene00007623", "Q9NEN6", "WBGene00004475", "Q9N306", "WBGene00022021", "Q23400", "WBGene00022852", "Q23312", "WBGene00004476", "Q20228", "WBGene00004478", "P48150", "WBGene00004483", "P41843", "WBGene00020601", "Q19545", "WBGene00007050", "Q93638", "WBGene00009266", "P91280", "WBGene00017855", "Q9U2I4", "WBGene00012756", "O01513", "WBGene00016740", "O62518", "WBGene00014083", "Q9XW58", "WBGene00013544", "Q2WF63", "WBGene00019219", "P42000", "WBGene00015104", "P91341", "WBGene00018891", "Q19433", "WBGene00017435", "O62477", "WBGene00012887", "O18215", "WBGene00013143", "P34305", "WBGene00015525", "Q9N3J4", "WBGene00021785", "G5EBX6", "WBGene00000796", "O16207", "WBGene00017916", "G5EDS8", "WBGene00009289", "Q95QG7", "WBGene00018305", "Q9XXD2", "WBGene00012966", "Q20128", "WBGene00018154", "Q95XD0", "WBGene00022232", "Q93830", "WBGene00010325", "Q17533", "WBGene00007201", "G5EG59", "WBGene00000798", "Q9N4P9", "WBGene00000202", "Q23223", "WBGene00012342", "WBGene00000796", "WBGene00000798", "WBGene00012342" ] }, "reaction_10558639": { "compartment": "compartment_7660", "id": "reaction_10558639", "reactome": "R-CEL-6791219", "name": "32S pre-rRNA is nucleolytically processed at site 4 (4a) to yield 12S pre-rRNA and 28S rRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10558620" ], "products": [ "species_10558572" ], "modifiers": [ [ "species_10558557", "catalyst" ], [ "species_10558562", "catalyst" ], [ "species_10558637", "catalyst" ], [ "species_10558618", "catalyst" ] ], "additional_components": [ "Q9U3B6", "WBGene00010709", "Q22006", "WBGene00004185", "Q9XWK5", "WBGene00012977", "O44984", "WBGene00006740", "Q09353", "WBGene00006736", "Q23238", "WBGene00006737", "Q95Y89", "WBGene00003063", "P91343", "WBGene00018893", "Q9U2A9", "WBGene00012978", "Q9U1T1", "WBGene00012393", "Q9U3B6", "WBGene00010709", "Q22006", "WBGene00004185", "Q9XWK5", "WBGene00012977", "O44984", "WBGene00006740", "Q09353", "WBGene00006736", "Q23238", "WBGene00006737", "Q9U1T1", "WBGene00012393", "WBGene00012393", "WBGene00010709", "Q17978", "WBGene00003507", "Q95Y89", "WBGene00003063", "Q09958", "WBGene00015941", "Q21086", "WBGene00003821", "Q95Y89", "WBGene00003063", "P91343", "WBGene00018893", "Q9U2A9", "WBGene00012978" ] }, "reaction_10570551": { "compartment": "compartment_70101", "id": "reaction_10570551", "reactome": "R-CEL-8983379", "name": "p-Y-STAT3:p-STAT5 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10570523" ], "products": [ "species_10570549" ], "modifiers": [], "additional_components": [ "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251" ] }, "reaction_10570525": { "compartment": "compartment_70101", "id": "reaction_10570525", "reactome": "R-CEL-8983373", "name": "p-Y-STAT3 binds p-STAT5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10570521", "species_10570515" ], "products": [ "species_10570523" ], "modifiers": [], "additional_components": [ "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111" ] }, "reaction_10533095": { "compartment": "compartment_7660", "id": "reaction_10533095", "reactome": "R-CEL-1363328", "name": "Phosphorylated p130 (RBL2) binds SCF(Skp2):Cks1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10532102", "species_10512514" ], "products": [ "species_10533093" ], "modifiers": [], "additional_components": [ "WBGene00003020", "G5ECU1", "WBGene00004807", "Q17389", "WBGene00000836", "Q17868", "WBGene00001051", "G5ECU1", "WBGene00004807", "Q17389", "WBGene00000836", "Q17868", "WBGene00001051", "G5EDT1", "WBGene00003020" ] }, "reaction_10533100": { "compartment": "compartment_7660", "id": "reaction_10533100", "reactome": "R-CEL-1363331", "name": "Ubiquitination of p130 (RBL2) by SCF (Skp2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502318", "species_10533093" ], "products": [ "species_10533097", "species_10512514" ], "modifiers": [ [ "species_10533093", "catalyst" ] ], "additional_components": [ "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "G5ECU1", "WBGene00004807", "Q17389", "WBGene00000836", "Q17868", "WBGene00001051", "G5EDT1", "WBGene00003020", "G5EDT1", "WBGene00003020", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "G5ECU1", "WBGene00004807", "Q17389", "WBGene00000836", "Q17868", "WBGene00001051", "G5ECU1", "WBGene00004807", "Q17389", "WBGene00000836", "Q17868", "WBGene00001051", "G5EDT1", "WBGene00003020" ] }, "reaction_10533069": { "compartment": "compartment_7660", "id": "reaction_10533069", "reactome": "R-CEL-1363274", "name": "Dephosphorylation of p107 (RBL1) by PP2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10532114" ], "products": [ "species_113550", "species_10532106" ], "modifiers": [ [ "species_10533066", "catalyst" ] ], "additional_components": [ "WBGene00003020", "WBGene00003020" ] }, "reaction_10533071": { "compartment": "compartment_7660", "id": "reaction_10533071", "reactome": "R-CEL-1363276", "name": "Dephosphorylation of p130 (RBL2) by PP2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10532102" ], "products": [ "species_113550", "species_10532081" ], "modifiers": [ [ "species_10533066", "catalyst" ] ], "additional_components": [ "WBGene00003020", "WBGene00003020" ] }, "reaction_10531928": { "compartment": "compartment_12045", "id": "reaction_10531928", "reactome": "R-CEL-1168376", "name": "STIM1 oligomerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10531921" ], "products": [ "species_10531923", "species_74016" ], "modifiers": [ [ "species_10531925", "catalyst" ] ], "additional_components": [ "species_74016", "G5EF60", "WBGene00021910", "G5EF60", "WBGene00021910", "Q9Y0A1", "WBGene00002173", "species_114520" ] }, "reaction_10542490": { "compartment": "compartment_12045", "id": "reaction_10542490", "reactome": "R-CEL-2089927", "name": "STIM1 binds TRPC1 forming STIM1:TRPC1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10542486", "species_10531923" ], "products": [ "species_10542488" ], "modifiers": [], "additional_components": [ "WBGene00006615", "G5EF60", "WBGene00021910", "G5EF60", "WBGene00021910", "Q8I6Y9", "WBGene00006615" ] }, "reaction_10542493": { "compartment": "compartment_70101", "id": "reaction_10542493", "reactome": "R-CEL-2089943", "name": "TRPC1 translocates calcium from the extracellular region to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74112" ], "products": [ "species_74016" ], "modifiers": [ [ "species_10542488", "catalyst" ] ], "additional_components": [ "G5EF60", "WBGene00021910", "Q8I6Y9", "WBGene00006615" ] }, "reaction_10514689": { "compartment": "compartment_70101", "id": "reaction_10514689", "reactome": "R-CEL-200681", "name": "FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29404", "species_200665", "species_113592" ], "products": [ "species_29372", "species_29370", "species_174404" ], "modifiers": [ [ "species_10513791", "catalyst" ] ], "additional_components": [ "WBGene00017777" ] }, "reaction_10513794": { "compartment": "compartment_70101", "id": "reaction_10513794", "reactome": "R-CEL-197958", "name": "FPGS-2 transforms THF to THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29404", "species_111355", "species_113592" ], "products": [ "species_29372", "species_29370", "species_197969" ], "modifiers": [ [ "species_10513791", "catalyst" ] ], "additional_components": [ "WBGene00017777" ] }, "reaction_10562914": { "compartment": "compartment_70101", "id": "reaction_10562914", "reactome": "R-CEL-6801342", "name": "MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6803257", "species_113592" ], "products": [ "species_29372", "species_70106", "species_29370", "species_200640" ], "modifiers": [ [ "species_10562911", "catalyst" ] ], "additional_components": [ "WBGene00013708" ] }, "reaction_10514628": { "compartment": "compartment_70101", "id": "reaction_10514628", "reactome": "R-CEL-200644", "name": "5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29366", "species_200739" ], "products": [ "species_70106", "species_29364", "species_200640" ], "modifiers": [ [ "species_10514625", "catalyst" ] ], "additional_components": [ "Q21285", "WBGene00000929" ] }, "reaction_10562916": { "compartment": "compartment_5460", "id": "reaction_10562916", "reactome": "R-CEL-6801456", "name": "MTHFD1L transforms 10-formyl-THF to HCOOH and THF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113548", "species_113581", "species_5389850" ], "products": [ "species_200671", "species_6801451", "species_113593" ], "modifiers": [ [ "species_10557703", "catalyst" ] ], "additional_components": [ "Q21285", "WBGene00000929" ] }, "reaction_10514694": { "compartment": "compartment_5460", "id": "reaction_10514694", "reactome": "R-CEL-200682", "name": "Mitochondrial FPGS-1 transforms THF to THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200671", "species_113593", "species_113552" ], "products": [ "species_113548", "species_113581", "species_200679" ], "modifiers": [ [ "species_10514691", "catalyst" ] ], "additional_components": [ "WBGene00017777" ] }, "reaction_10514697": { "compartment": "compartment_70101", "id": "reaction_10514697", "reactome": "R-CEL-200711", "name": "MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_29460", "species_197969" ], "products": [ "species_29372", "species_29370", "species_111353" ], "modifiers": [ [ "species_10514625", "catalyst" ] ], "additional_components": [ "Q21285", "WBGene00000929" ] }, "reaction_10514666": { "compartment": "compartment_876", "id": "reaction_10514666", "reactome": "R-CEL-200652", "name": "SLC19A1 transports 5-methyl-THF from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200709" ], "products": [ "species_200665" ], "modifiers": [ [ "species_10514663", "catalyst" ] ], "additional_components": [ "O45166", "WBGene00018138", "Q17766", "WBGene00007388", "Q22931", "WBGene00044738" ] }, "reaction_10513802": { "compartment": "compartment_70101", "id": "reaction_10513802", "reactome": "R-CEL-197963", "name": "DHFR2 reduces FOLA to DHF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_197965", "species_70106", "species_29364" ], "products": [ "species_29366", "species_73604" ], "modifiers": [ [ "species_10513799", "catalyst" ] ], "additional_components": [ "WBGene00007974" ] }, "reaction_10557706": { "compartment": "compartment_5460", "id": "reaction_10557706", "reactome": "R-CEL-5696839", "name": "MTHFD1L dimer ligates HCOOH to THF to form 10-formyl-THF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6801451", "species_200671", "species_113593" ], "products": [ "species_113548", "species_113581", "species_5389850" ], "modifiers": [ [ "species_10557703", "catalyst" ] ], "additional_components": [ "Q21285", "WBGene00000929" ] }, "reaction_10514699": { "compartment": "compartment_70101", "id": "reaction_10514699", "reactome": "R-CEL-200718", "name": "MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_200640" ], "products": [ "species_29366", "species_200739" ], "modifiers": [ [ "species_10514625", "catalyst" ] ], "additional_components": [ "Q21285", "WBGene00000929" ] }, "reaction_10513804": { "compartment": "compartment_70101", "id": "reaction_10513804", "reactome": "R-CEL-197972", "name": "DHF is reduced to tetrahydrofolate (THF)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_73604", "species_29364" ], "products": [ "species_111355", "species_29366" ], "modifiers": [ [ "species_10513799", "catalyst" ] ], "additional_components": [ "WBGene00007974" ] }, "reaction_10514701": { "compartment": "compartment_70616", "id": "reaction_10514701", "reactome": "R-CEL-200720", "name": "SLC25A32 transports THF from mitochondrial matrix to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200671" ], "products": [ "species_111355" ], "modifiers": [ [ "species_10514684", "catalyst" ] ], "additional_components": [ "WBGene00010459" ] }, "reaction_10514669": { "compartment": "compartment_70101", "id": "reaction_10514669", "reactome": "R-CEL-200661", "name": "MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111353" ], "products": [ "species_29356", "species_200640" ], "modifiers": [ [ "species_10514625", "catalyst" ] ], "additional_components": [ "Q21285", "WBGene00000929" ] }, "reaction_10514703": { "compartment": "compartment_876", "id": "reaction_10514703", "reactome": "R-CEL-200729", "name": "SLC46A1 transports FOLA from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200716" ], "products": [ "species_197965" ], "modifiers": [ [ "species_10514650", "catalyst" ] ], "additional_components": [ "Q9UAZ6", "WBGene00021159", "Q9XWL3", "WBGene00012811", "H2KZC0", "WBGene00016705", "Q20236", "WBGene00009582" ] }, "reaction_10563441": { "compartment": "compartment_5460", "id": "reaction_10563441", "reactome": "R-CEL-6808487", "name": "ALDH1L2 dehydrogenates 10-formyl-THFPG to THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113563", "species_6808499", "species_113521" ], "products": [ "species_113529", "species_200679", "species_113600", "species_29376" ], "modifiers": [ [ "species_10563438", "catalyst" ] ], "additional_components": [ "G5ECV9", "WBGene00000109" ] }, "reaction_10514705": { "compartment": "compartment_70101", "id": "reaction_10514705", "reactome": "R-CEL-200735", "name": "SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200736", "species_197969" ], "products": [ "species_29424", "species_200739" ], "modifiers": [ [ "species_10503873", "catalyst" ] ], "additional_components": [ "P50432", "WBGene00003214" ] }, "reaction_10514707": { "compartment": "compartment_70101", "id": "reaction_10514707", "reactome": "R-CEL-200740", "name": "5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_200640" ], "products": [ "species_111353" ], "modifiers": [ [ "species_10514625", "catalyst" ] ], "additional_components": [ "Q21285", "WBGene00000929" ] }, "reaction_10573332": { "compartment": "compartment_70101", "id": "reaction_10573332", "reactome": "R-CEL-9709098", "name": "DHFR dimer reduces FOLA to DHF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_197965", "species_70106", "species_29364" ], "products": [ "species_29366", "species_73604" ], "modifiers": [ [ "species_10573329", "catalyst" ] ], "additional_components": [ "Q93341", "WBGene00007974" ] }, "reaction_10514679": { "compartment": "compartment_70101", "id": "reaction_10514679", "reactome": "R-CEL-200676", "name": "MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_200739" ], "products": [ "species_29366", "species_174404" ], "modifiers": [ [ "species_10514676", "catalyst" ] ], "additional_components": [ "Q17693", "WBGene00015512" ] }, "reaction_10563449": { "compartment": "compartment_70101", "id": "reaction_10563449", "reactome": "R-CEL-6808496", "name": "ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_111353", "species_29366" ], "products": [ "species_70106", "species_113528", "species_29364", "species_197969" ], "modifiers": [ [ "species_10563446", "catalyst" ] ], "additional_components": [ "G5ECV9", "WBGene00000109" ] }, "reaction_10514653": { "compartment": "compartment_876", "id": "reaction_10514653", "reactome": "R-CEL-200646", "name": "Cytosolic folate export across the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_197965" ], "products": [ "species_200716" ], "modifiers": [ [ "species_10514650", "catalyst" ] ], "additional_components": [ "Q9UAZ6", "WBGene00021159", "Q9XWL3", "WBGene00012811", "H2KZC0", "WBGene00016705", "Q20236", "WBGene00009582" ] }, "reaction_10514655": { "compartment": "compartment_70101", "id": "reaction_10514655", "reactome": "R-CEL-200651", "name": "5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29424", "species_200739" ], "products": [ "species_200736", "species_197969" ], "modifiers": [ [ "species_10503873", "catalyst" ] ], "additional_components": [ "P50432", "WBGene00003214" ] }, "reaction_10507440": { "compartment": "compartment_7660", "id": "reaction_10507440", "reactome": "R-CEL-75866", "name": "Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10507428" ], "products": [ "species_10507436" ], "modifiers": [], "additional_components": [ "G5EG49", "WBGene00013998", "G5EG47", "WBGene00010054", "O44625", "WBGene00004136", "Q9NEX2", "WBGene00013736", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "species_110614", "species_29358", "species_29494", "species_29438", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q95ZS0", "WBGene00006392", "Q9GZI6", "WBGene00006387", "G5EF68", "WBGene00006386", "O45784", "WBGene00006391", "P32085", "WBGene00006542", "O61707", "WBGene00006385", "Q9NEW8", "WBGene00006389", "Q9TYN3", "WBGene00006383", "Q18265", "WBGene00016173", "Q17957", "WBGene00006397", "E9P861", "WBGene00006384", "Q20361", "WBGene00006395", "G5EGM3", "WBGene00006382", "O16991", "WBGene00006648", "G5EG49", "WBGene00013998", "G5EG47", "WBGene00010054", "O44625", "WBGene00004136", "Q9NEX2", "WBGene00013736", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q95ZS0", "WBGene00006392", "Q9GZI6", "WBGene00006387", "G5EF68", "WBGene00006386", "O45784", "WBGene00006391", "P32085", "WBGene00006542", "O61707", "WBGene00006385", "Q9NEW8", "WBGene00006389", "Q9TYN3", "WBGene00006383", "Q18265", "WBGene00016173", "Q17957", "WBGene00006397", "E9P861", "WBGene00006384", "Q20361", "WBGene00006395", "G5EGM3", "WBGene00006382", "O16991", "WBGene00006648", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529" ] }, "reaction_10507430": { "compartment": "compartment_7660", "id": "reaction_10507430", "reactome": "R-CEL-75861", "name": "NTP Binds Active Site of RNA Polymerase II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30595", "species_10507424" ], "products": [ "species_10507428" ], "modifiers": [], "additional_components": [ "species_110614", "species_29358", "species_29494", "species_29438", "G5EG49", "WBGene00013998", "G5EG47", "WBGene00010054", "O44625", "WBGene00004136", "Q9NEX2", "WBGene00013736", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q95ZS0", "WBGene00006392", "Q9GZI6", "WBGene00006387", "G5EF68", "WBGene00006386", "O45784", "WBGene00006391", "P32085", "WBGene00006542", "O61707", "WBGene00006385", "Q9NEW8", "WBGene00006389", "Q9TYN3", "WBGene00006383", "Q18265", "WBGene00016173", "Q17957", "WBGene00006397", "E9P861", "WBGene00006384", "Q20361", "WBGene00006395", "G5EGM3", "WBGene00006382", "O16991", "WBGene00006648", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "G5EG49", "WBGene00013998", "G5EG47", "WBGene00010054", "O44625", "WBGene00004136", "Q9NEX2", "WBGene00013736", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "species_110614", "species_29358", "species_29494", "species_29438", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q95ZS0", "WBGene00006392", "Q9GZI6", "WBGene00006387", "G5EF68", "WBGene00006386", "O45784", "WBGene00006391", "P32085", "WBGene00006542", "O61707", "WBGene00006385", "Q9NEW8", "WBGene00006389", "Q9TYN3", "WBGene00006383", "Q18265", "WBGene00016173", "Q17957", "WBGene00006397", "E9P861", "WBGene00006384", "Q20361", "WBGene00006395", "G5EGM3", "WBGene00006382", "O16991", "WBGene00006648" ] }, "reaction_10507438": { "compartment": "compartment_7660", "id": "reaction_10507438", "reactome": "R-CEL-75864", "name": "Newly Formed Phosphodiester Bond Stabilized and PPi Released", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10507436" ], "products": [ "species_113541", "species_10506530" ], "modifiers": [], "additional_components": [ "G5EG49", "WBGene00013998", "G5EG47", "WBGene00010054", "O44625", "WBGene00004136", "Q9NEX2", "WBGene00013736", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q95ZS0", "WBGene00006392", "Q9GZI6", "WBGene00006387", "G5EF68", "WBGene00006386", "O45784", "WBGene00006391", "P32085", "WBGene00006542", "O61707", "WBGene00006385", "Q9NEW8", "WBGene00006389", "Q9TYN3", "WBGene00006383", "Q18265", "WBGene00016173", "Q17957", "WBGene00006397", "E9P861", "WBGene00006384", "Q20361", "WBGene00006395", "G5EGM3", "WBGene00006382", "O16991", "WBGene00006648", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "G5EG49", "WBGene00013998", "G5EG47", "WBGene00010054", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "O44625", "WBGene00004136", "Q9NEX2", "WBGene00013736", "Q95ZS0", "WBGene00006392", "Q9GZI6", "WBGene00006387", "G5EF68", "WBGene00006386", "O45784", "WBGene00006391", "P32085", "WBGene00006542", "O61707", "WBGene00006385", "Q9NEW8", "WBGene00006389", "Q9TYN3", "WBGene00006383", "Q18265", "WBGene00016173", "Q17957", "WBGene00006397", "E9P861", "WBGene00006384", "Q20361", "WBGene00006395", "G5EGM3", "WBGene00006382", "O16991", "WBGene00006648", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529" ] }, "reaction_10568438": { "compartment": "compartment_7660", "id": "reaction_10568438", "reactome": "R-CEL-8938913", "name": "RUNX1 binds ELF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10566201", "species_10568434" ], "products": [ "species_10568436" ], "modifiers": [], "additional_components": [ "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "WBGene00016029", "H2KYY1", "WBGene00016029", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393" ] }, "reaction_10558118": { "compartment": "compartment_70101", "id": "reaction_10558118", "reactome": "R-CEL-6785648", "name": "MEMO1 binds RHOA:GTP:DIAPH1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10558114", "species_10554688" ], "products": [ "species_10558116" ], "modifiers": [], "additional_components": [ "Q22915", "WBGene00016500", "Q22038", "WBGene00004357", "species_29438", "Q19479", "WBGene00008848", "Q7JP75", "WBGene00000872", "Q22038", "WBGene00004357", "species_29438", "Q19479", "WBGene00008848", "Q7JP75", "WBGene00000872", "Q22915", "WBGene00016500" ] }, "reaction_10520920": { "compartment": "compartment_70101", "id": "reaction_10520920", "reactome": "R-CEL-391266", "name": "Association of CCT/TriC with sphingosine kinase 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10520872", "species_10520916" ], "products": [ "species_10520918" ], "modifiers": [], "additional_components": [ "WBGene00007918", "P46550", "WBGene00000381", "Q9TZS5", "WBGene00020391", "P47207", "WBGene00000378", "Q9N4J8", "WBGene00018782", "P47208", "WBGene00000379", "species_113582", "Q9N358", "WBGene00021934", "P47209", "WBGene00000380", "P41988", "WBGene00000377", "P46550", "WBGene00000381", "Q9TZS5", "WBGene00020391", "P47207", "WBGene00000378", "Q9N4J8", "WBGene00018782", "P47208", "WBGene00000379", "species_113582", "Q9N358", "WBGene00021934", "P47209", "WBGene00000380", "P41988", "WBGene00000377", "Q18425", "WBGene00007918" ] }, "reaction_10564273": { "compartment": "compartment_70101", "id": "reaction_10564273", "reactome": "R-CEL-6814418", "name": "PDCL promotes formation of G-beta:G-gamma heterodimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509151", "species_10564267" ], "products": [ "species_10564271" ], "modifiers": [], "additional_components": [ "P54406", "WBGene00001681", "P17343", "WBGene00001679", "Q9U1X7", "WBGene00003142", "Q9U1X7", "WBGene00003142", "P17343", "WBGene00001679", "P54406", "WBGene00001681" ] }, "reaction_10565025": { "compartment": "compartment_70101", "id": "reaction_10565025", "reactome": "R-CEL-8850560", "name": "G-protein alpha releases G-protein heterotrimer from PDCL ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10564271", "species_10508935" ], "products": [ "species_10565023", "species_10564228" ], "modifiers": [], "additional_components": [ "Q9U1X7", "WBGene00003142", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196", "P17343", "WBGene00001679", "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196", "P54406", "WBGene00001681", "WBGene00003142" ] }, "reaction_10564213": { "compartment": "compartment_70101", "id": "reaction_10564213", "reactome": "R-CEL-6814119", "name": "TRiC/CCT binds unfolded G-protein beta subunit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509163", "species_10520916" ], "products": [ "species_10564211" ], "modifiers": [], "additional_components": [ "P17343", "WBGene00001679", "P46550", "WBGene00000381", "Q9TZS5", "WBGene00020391", "P47207", "WBGene00000378", "Q9N4J8", "WBGene00018782", "P47208", "WBGene00000379", "species_113582", "Q9N358", "WBGene00021934", "P47209", "WBGene00000380", "P41988", "WBGene00000377", "P46550", "WBGene00000381", "Q9TZS5", "WBGene00020391", "P47207", "WBGene00000378", "Q9N4J8", "WBGene00018782", "P47208", "WBGene00000379", "species_113582", "Q9N358", "WBGene00021934", "P47209", "WBGene00000380", "P41988", "WBGene00000377", "P17343", "WBGene00001679" ] }, "reaction_10565013": { "compartment": "compartment_70101", "id": "reaction_10565013", "reactome": "R-CEL-8850529", "name": "RGS proteins bind GNB5 and CCT/TRiC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10565009", "species_10564993" ], "products": [ "species_10565011" ], "modifiers": [], "additional_components": [ "P49809", "WBGene00001179", "O17589", "WBGene00001145", "P46550", "WBGene00000381", "Q9TZS5", "WBGene00020391", "P47207", "WBGene00000378", "Q9N4J8", "WBGene00018782", "P47208", "WBGene00000379", "species_113582", "Q9N358", "WBGene00021934", "P47209", "WBGene00000380", "P41988", "WBGene00000377", "Q20636", "WBGene00001680", "P46550", "WBGene00000381", "Q9TZS5", "WBGene00020391", "P47207", "WBGene00000378", "Q9N4J8", "WBGene00018782", "P47208", "WBGene00000379", "species_113582", "Q9N358", "WBGene00021934", "P47209", "WBGene00000380", "P41988", "WBGene00000377", "Q20636", "WBGene00001680", "P49809", "WBGene00001179", "O17589", "WBGene00001145" ] }, "reaction_10564265": { "compartment": "compartment_70101", "id": "reaction_10564265", "reactome": "R-CEL-6814409", "name": "CK2 phosphorylates PDCL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10564263" ], "products": [ "species_29370", "species_10564228" ], "modifiers": [ [ "species_10515097", "catalyst" ] ], "additional_components": [ "WBGene00003142", "WBGene00003142", "P18334", "WBGene00002191", "P28548", "WBGene00002196" ] }, "reaction_10565017": { "compartment": "compartment_70101", "id": "reaction_10565017", "reactome": "R-CEL-8850534", "name": "PDCL promotes G-protein beta 5 folding", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10565015" ], "products": [ "species_10564228", "species_10564993" ], "modifiers": [], "additional_components": [ "P46550", "WBGene00000381", "Q9TZS5", "WBGene00020391", "P47207", "WBGene00000378", "Q9N4J8", "WBGene00018782", "P47208", "WBGene00000379", "species_113582", "Q9N358", "WBGene00021934", "P47209", "WBGene00000380", "P41988", "WBGene00000377", "Q20636", "WBGene00001680", "Q9U1X7", "WBGene00003142", "WBGene00003142", "P46550", "WBGene00000381", "Q9TZS5", "WBGene00020391", "P47207", "WBGene00000378", "Q9N4J8", "WBGene00018782", "P47208", "WBGene00000379", "species_113582", "Q9N358", "WBGene00021934", "P47209", "WBGene00000380", "P41988", "WBGene00000377", "Q20636", "WBGene00001680" ] }, "reaction_10564232": { "compartment": "compartment_70101", "id": "reaction_10564232", "reactome": "R-CEL-6814121", "name": "PDCL binds G-protein beta and TRiC/CCT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10564228", "species_10564211" ], "products": [ "species_10564230" ], "modifiers": [], "additional_components": [ "WBGene00003142", "P46550", "WBGene00000381", "Q9TZS5", "WBGene00020391", "P47207", "WBGene00000378", "Q9N4J8", "WBGene00018782", "P47208", "WBGene00000379", "species_113582", "Q9N358", "WBGene00021934", "P47209", "WBGene00000380", "P41988", "WBGene00000377", "P17343", "WBGene00001679", "P46550", "WBGene00000381", "Q9TZS5", "WBGene00020391", "P47207", "WBGene00000378", "Q9N4J8", "WBGene00018782", "P47208", "WBGene00000379", "species_113582", "Q9N358", "WBGene00021934", "P47209", "WBGene00000380", "P41988", "WBGene00000377", "P17343", "WBGene00001679", "Q9U1X7", "WBGene00003142" ] }, "reaction_10564219": { "compartment": "compartment_70101", "id": "reaction_10564219", "reactome": "R-CEL-6814120", "name": "ATP hydrolysis promotes folding of G-protein beta by TRiC/CCT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10564217" ], "products": [ "species_29372", "species_10564211" ], "modifiers": [], "additional_components": [ "P46550", "WBGene00000381", "Q9TZS5", "WBGene00020391", "P47207", "WBGene00000378", "Q9N4J8", "WBGene00018782", "P47208", "WBGene00000379", "species_29358", "Q9N358", "WBGene00021934", "P47209", "WBGene00000380", "P41988", "WBGene00000377", "P17343", "WBGene00001679", "P46550", "WBGene00000381", "Q9TZS5", "WBGene00020391", "P47207", "WBGene00000378", "Q9N4J8", "WBGene00018782", "P47208", "WBGene00000379", "species_113582", "Q9N358", "WBGene00021934", "P47209", "WBGene00000380", "P41988", "WBGene00000377", "P17343", "WBGene00001679" ] }, "reaction_10564234": { "compartment": "compartment_70101", "id": "reaction_10564234", "reactome": "R-CEL-6814124", "name": "ATP binds G-protein beta associated TRiC/CCT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10564211" ], "products": [ "species_29370", "species_10564217" ], "modifiers": [], "additional_components": [ "P46550", "WBGene00000381", "Q9TZS5", "WBGene00020391", "P47207", "WBGene00000378", "Q9N4J8", "WBGene00018782", "P47208", "WBGene00000379", "species_113582", "Q9N358", "WBGene00021934", "P47209", "WBGene00000380", "P41988", "WBGene00000377", "P17343", "WBGene00001679", "P46550", "WBGene00000381", "Q9TZS5", "WBGene00020391", "P47207", "WBGene00000378", "Q9N4J8", "WBGene00018782", "P47208", "WBGene00000379", "species_29358", "Q9N358", "WBGene00021934", "P47209", "WBGene00000380", "P41988", "WBGene00000377", "P17343", "WBGene00001679" ] }, "reaction_10565021": { "compartment": "compartment_70101", "id": "reaction_10565021", "reactome": "R-CEL-8850539", "name": "Release of GNB5:RGS dimers from CCT/TRiC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10565011" ], "products": [ "species_10565019", "species_10520916" ], "modifiers": [], "additional_components": [ "P46550", "WBGene00000381", "Q9TZS5", "WBGene00020391", "P47207", "WBGene00000378", "Q9N4J8", "WBGene00018782", "P47208", "WBGene00000379", "species_113582", "Q9N358", "WBGene00021934", "P47209", "WBGene00000380", "P41988", "WBGene00000377", "Q20636", "WBGene00001680", "P49809", "WBGene00001179", "O17589", "WBGene00001145", "P49809", "WBGene00001179", "O17589", "WBGene00001145", "Q20636", "WBGene00001680", "P46550", "WBGene00000381", "Q9TZS5", "WBGene00020391", "P47207", "WBGene00000378", "Q9N4J8", "WBGene00018782", "P47208", "WBGene00000379", "species_113582", "Q9N358", "WBGene00021934", "P47209", "WBGene00000380", "P41988", "WBGene00000377" ] }, "reaction_10564991": { "compartment": "compartment_70101", "id": "reaction_10564991", "reactome": "R-CEL-8850527", "name": "PDCL releases folded G-beta from TRiC/CCT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10564989" ], "products": [ "species_10564267", "species_10520916" ], "modifiers": [], "additional_components": [ "Q9U1X7", "WBGene00003142", "P46550", "WBGene00000381", "Q9TZS5", "WBGene00020391", "P47207", "WBGene00000378", "Q9N4J8", "WBGene00018782", "P47208", "WBGene00000379", "species_113582", "Q9N358", "WBGene00021934", "P47209", "WBGene00000380", "P41988", "WBGene00000377", "P17343", "WBGene00001679", "P17343", "WBGene00001679", "Q9U1X7", "WBGene00003142", "P46550", "WBGene00000381", "Q9TZS5", "WBGene00020391", "P47207", "WBGene00000378", "Q9N4J8", "WBGene00018782", "P47208", "WBGene00000379", "species_113582", "Q9N358", "WBGene00021934", "P47209", "WBGene00000380", "P41988", "WBGene00000377" ] }, "reaction_10524242": { "compartment": "compartment_876", "id": "reaction_10524242", "reactome": "R-CEL-437300", "name": "SLC31A1 transports Cu2+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_437295" ], "products": [ "species_209799" ], "modifiers": [ [ "species_10524239", "catalyst" ] ], "additional_components": [ "WBGene00017852" ] }, "reaction_10524450": { "compartment": "compartment_876", "id": "reaction_10524450", "reactome": "R-CEL-442661", "name": "SLC41A1,2 transport Mg2+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_114632" ], "products": [ "species_29926" ], "modifiers": [ [ "species_10524447", "catalyst" ] ], "additional_components": [ "O02340", "WBGene00022682", "O44196", "WBGene00022682", "O45182", "WBGene00022682" ] }, "reaction_10524215": { "compartment": "compartment_1462052", "id": "reaction_10524215", "reactome": "R-CEL-437085", "name": "ZnT5 transports zinc into secretory granules in pancreatic beta cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29426" ], "products": [ "species_216785" ], "modifiers": [ [ "species_10524212", "catalyst" ] ], "additional_components": [ "WBGene00013668" ] }, "reaction_10524231": { "compartment": "compartment_20699", "id": "reaction_10524231", "reactome": "R-CEL-437139", "name": "ZnT6 transports zinc into the golgi apparatus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29426" ], "products": [ "species_216667" ], "modifiers": [ [ "species_10524228", "catalyst" ] ], "additional_components": [ "WBGene00006590" ] }, "reaction_10524207": { "compartment": "compartment_876", "id": "reaction_10524207", "reactome": "R-CEL-435366", "name": "ZnT1 mediates the efflux of zinc from the cell", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29426" ], "products": [ "species_158417" ], "modifiers": [ [ "species_10524204", "catalyst" ] ], "additional_components": [ "WBGene00000393" ] }, "reaction_10524223": { "compartment": "compartment_20699", "id": "reaction_10524223", "reactome": "R-CEL-437136", "name": "SLC30A8 transports Zn2+ from cytosol to secretory granule", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29426" ], "products": [ "species_216785" ], "modifiers": [ [ "species_10524220", "catalyst" ] ], "additional_components": [ "WBGene00011821" ] }, "reaction_10524385": { "compartment": "compartment_12045", "id": "reaction_10524385", "reactome": "R-CEL-442393", "name": "ZIP7 mediates zinc efflux from the endoplasmic reticulum", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_442320" ], "products": [ "species_29426" ], "modifiers": [ [ "species_10524382", "catalyst" ] ], "additional_components": [ "WBGene00006494" ] }, "reaction_10524344": { "compartment": "compartment_876", "id": "reaction_10524344", "reactome": "R-CEL-442317", "name": "ZIP6 and ZIP14 mediate zinc influx into cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158417" ], "products": [ "species_29426" ], "modifiers": [ [ "species_10524341", "catalyst" ] ], "additional_components": [ "U4PS08", "WBGene00021936", "Q22395", "WBGene00006486" ] }, "reaction_10524377": { "compartment": "compartment_876", "id": "reaction_10524377", "reactome": "R-CEL-442387", "name": "ZIP8 mediates zinc influx into cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158417" ], "products": [ "species_29426" ], "modifiers": [ [ "species_10524374", "catalyst" ] ], "additional_components": [ "Q22395", "WBGene00006486", "U4PS08", "WBGene00021936" ] }, "reaction_10524426": { "compartment": "compartment_876", "id": "reaction_10524426", "reactome": "R-CEL-442422", "name": "SLC39A1-4 transports Zn2+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158417" ], "products": [ "species_29426" ], "modifiers": [ [ "species_10524423", "catalyst" ] ], "additional_components": [ "Q09957", "WBGene00015940", "U4PS08", "WBGene00021936", "P91348", "WBGene00018897", "Q19913", "WBGene00017936", "Q6BEU0", "WBGene00014669", "O62192", "WBGene00009286", "Q9XWH3", "WBGene00013207" ] }, "reaction_10524199": { "compartment": "compartment_876", "id": "reaction_10524199", "reactome": "R-CEL-435349", "name": "SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_435347" ], "products": [ "species_70106", "species_71067" ], "modifiers": [ [ "species_10524196", "catalyst" ] ], "additional_components": [ "WBGene00004876" ] }, "reaction_10570186": { "compartment": "compartment_70101", "id": "reaction_10570186", "reactome": "R-CEL-8959798", "name": "SLC30A10 transports Mn2+ from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29418" ], "products": [ "species_266099" ], "modifiers": [ [ "species_10570183", "catalyst" ] ], "additional_components": [ "WBGene00000393" ] }, "reaction_10524366": { "compartment": "compartment_876", "id": "reaction_10524366", "reactome": "R-CEL-442368", "name": "SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71067" ], "products": [ "species_435347" ], "modifiers": [ [ "species_10524363", "catalyst" ] ], "additional_components": [ "O44607", "WBGene00019977", "Q8IA95", "WBGene00021354", "CHEBI:28694", "Q19687", "WBGene00009008" ] }, "reaction_10528430": { "compartment": "compartment_876", "id": "reaction_10528430", "reactome": "R-CEL-904830", "name": "SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71067" ], "products": [ "species_435347" ], "modifiers": [ [ "species_10528427", "catalyst" ] ], "additional_components": [ "Q19687", "WBGene00009008", "species_209799", "O44607", "WBGene00019977", "Q8IA95", "WBGene00021354" ] }, "reaction_10507115": { "compartment": "compartment_7660", "id": "reaction_10507115", "reactome": "R-CEL-75079", "name": "Formation of AT-AC C complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10507111" ], "products": [ "species_10507103", "species_10507113" ], "modifiers": [], "additional_components": [ "Q17348", "WBGene00004914", "Q9N4G9", "WBGene00004920", "Q18786", "WBGene00004917", "P91918", "WBGene00004915", "Q9XTU6", "WBGene00004919", "Q10013", "WBGene00004916", "P34659", "WBGene00004918", "Q23463", "WBGene00001166", "O02097", "WBGene00015974", "P92022", "WBGene00001808", "Q21568", "WBGene00010896", "Q9U2G0", "WBGene00012896", "Q95QN2", "WBGene00017162", "P34369", "WBGene00004187", "Q9GRZ2", "WBGene00013343", "L8E6I4", "WBGene00235102", "Q23120", "WBGene00004699", "Q9NEW6", "WBGene00004700", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "Q09511", "WBGene00004701", "O44985", "WBGene00019323", "G5EEQ8", "WBGene00011605", "Q8ITY4", "WBGene00016808", "O16997", "WBGene00021004", "Q93382", "WBGene00008119", "P91306", "WBGene00000473", "Q17348", "WBGene00004914", "Q9N4G9", "WBGene00004920", "Q18786", "WBGene00004917", "P91918", "WBGene00004915", "Q9XTU6", "WBGene00004919", "Q10013", "WBGene00004916", "P34659", "WBGene00004918", "Q23120", "WBGene00004699", "Q9NEW6", "WBGene00004700", "Q17348", "WBGene00004914", "Q9N4G9", "WBGene00004920", "Q18786", "WBGene00004917", "P91918", "WBGene00004915", "Q9XTU6", "WBGene00004919", "Q10013", "WBGene00004916", "P34659", "WBGene00004918", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "Q09511", "WBGene00004701", "O44985", "WBGene00019323", "G5EEQ8", "WBGene00011605", "Q8ITY4", "WBGene00016808", "O16997", "WBGene00021004", "Q93382", "WBGene00008119", "P91306", "WBGene00000473", "Q23463", "WBGene00001166", "O02097", "WBGene00015974", "P92022", "WBGene00001808", "Q21568", "WBGene00010896", "Q9U2G0", "WBGene00012896", "Q95QN2", "WBGene00017162", "P34369", "WBGene00004187", "Q9GRZ2", "WBGene00013343", "L8E6I4", "WBGene00235102" ] }, "reaction_10507117": { "compartment": "compartment_7660", "id": "reaction_10507117", "reactome": "R-CEL-75082", "name": "ATAC spliceosome mediated Lariat formation,5' splice site cleavage", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10507113" ], "products": [ "species_10507113" ], "modifiers": [], "additional_components": [ "Q23120", "WBGene00004699", "Q9NEW6", "WBGene00004700", "Q17348", "WBGene00004914", "Q9N4G9", "WBGene00004920", "Q18786", "WBGene00004917", "P91918", "WBGene00004915", "Q9XTU6", "WBGene00004919", "Q10013", "WBGene00004916", "P34659", "WBGene00004918", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "Q09511", "WBGene00004701", "O44985", "WBGene00019323", "G5EEQ8", "WBGene00011605", "Q8ITY4", "WBGene00016808", "O16997", "WBGene00021004", "Q93382", "WBGene00008119", "P91306", "WBGene00000473", "Q23463", "WBGene00001166", "O02097", "WBGene00015974", "P92022", "WBGene00001808", "Q21568", "WBGene00010896", "Q9U2G0", "WBGene00012896", "Q95QN2", "WBGene00017162", "P34369", "WBGene00004187", "Q9GRZ2", "WBGene00013343", "L8E6I4", "WBGene00235102", "Q23120", "WBGene00004699", "Q9NEW6", "WBGene00004700", "Q17348", "WBGene00004914", "Q9N4G9", "WBGene00004920", "Q18786", "WBGene00004917", "P91918", "WBGene00004915", "Q9XTU6", "WBGene00004919", "Q10013", "WBGene00004916", "P34659", "WBGene00004918", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "Q09511", "WBGene00004701", "O44985", "WBGene00019323", "G5EEQ8", "WBGene00011605", "Q8ITY4", "WBGene00016808", "O16997", "WBGene00021004", "Q93382", "WBGene00008119", "P91306", "WBGene00000473", "Q23463", "WBGene00001166", "O02097", "WBGene00015974", "P92022", "WBGene00001808", "Q21568", "WBGene00010896", "Q9U2G0", "WBGene00012896", "Q95QN2", "WBGene00017162", "P34369", "WBGene00004187", "Q9GRZ2", "WBGene00013343", "L8E6I4", "WBGene00235102" ] }, "reaction_10505265": { "compartment": "compartment_7660", "id": "reaction_10505265", "reactome": "R-CEL-72139", "name": "Formation of the active Spliceosomal C (B*) complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10505258" ], "products": [ "species_10505262", "species_10505252" ], "modifiers": [ [ "species_10505258", "catalyst" ] ], "additional_components": [ "P34313", "WBGene00007400", "P91306", "WBGene00000473", "Q9U1Q7", "WBGene00001258", "Q18265", "WBGene00016173", "Q22307", "WBGene00004355", "Q17336", "WBGene00002957", "Q18409", "WBGene00004703", "Q9NEW6", "WBGene00004700", "Q22412", "WBGene00011722", "Q23120", "WBGene00004699", "Q966L5", "WBGene00017085", "Q965K2", "WBGene00018776", "Q21322", "WBGene00004385", "Q21323", "WBGene00004386", "Q20875", "WBGene00018967", "Q9N3S4", "WBGene00004389", "Q20966", "WBGene00010233", "O44985", "WBGene00019323", "G5EEQ8", "WBGene00011605", "Q8ITY4", "WBGene00016808", "O16997", "WBGene00021004", "Q93382", "WBGene00008119", "Q22469", "WBGene00011758", "G5ECL3", "WBGene00004188", "Q19335", "WBGene00008683", "Q95Y51", "WBGene00004891", "G5EBY6", "WBGene00004016", 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10505213", "species_10505197", "species_10505225", "species_10505192", "species_10505175", "species_10505156" ], "products": [ "species_10505227" ], "modifiers": [], "additional_components": [ "Q93716", "WBGene00009668", "C1P629", "WBGene00008362", "WBGene00003904", "P52874", "WBGene00010304", "Q09345", "WBGene00020092", "Q09995", "WBGene00011791", "Q9U2P3", "WBGene00012528", "G5EBX5", "WBGene00009658", "O45577", "WBGene00000774", "Q19864", "WBGene00000773", "Q19866", "WBGene00006307", "Q95PY8", "WBGene00013460", "U4PCM1", "WBGene00011051", "Q9N4C2", "WBGene00022301", "Q7YTG9", "WBGene00044329", "O17403", "WBGene00017313", "O16929", "WBGene00017797", "Q95PY8", "WBGene00013460", "U4PCM1", "WBGene00011051", "Q9N4C2", "WBGene00022301", "Q7YTG9", "WBGene00044329", "O17403", "WBGene00017313", "O16929", "WBGene00017797", "O45577", "WBGene00000774", "Q19864", "WBGene00000773", "Q19866", "WBGene00006307", "Q09995", "WBGene00011791", "Q9U2P3", "WBGene00012528", "G5EBX5", "WBGene00009658", "P52874", "WBGene00010304", "Q09345", "WBGene00020092", "Q93233", "WBGene00003904", "Q93716", "WBGene00009668", "C1P629", "WBGene00008362" ] }, "reaction_10505260": { "compartment": "compartment_7660", "id": "reaction_10505260", "reactome": "R-CEL-72130", "name": "Formation of an intermediate Spliceosomal C (Bact) complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10505291", "species_10509834" ], "products": [ "species_10505299" ], "modifiers": [], "additional_components": [ "Q21832", "WBGene00004387", "P49029", "WBGene00003123", "Q9U1Q7", "WBGene00001258", "Q18265", "WBGene00016173", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "Q22307", "WBGene00004355", "Q17336", "WBGene00002957", "Q18409", "WBGene00004703", "Q9NEW6", "WBGene00004700", "Q22412", "WBGene00011722", "Q23120", "WBGene00004699", "Q966L5", "WBGene00017085", "Q965K2", "WBGene00018776", "Q21322", "WBGene00004385", "Q21323", "WBGene00004386", "Q20875", "WBGene00018967", "Q9N3S4", "WBGene00004389", "Q20966", "WBGene00010233", "O44985", "WBGene00019323", "G5EEQ8", "WBGene00011605", "Q8ITY4", "WBGene00016808", "O16997", "WBGene00021004", "Q93382", "WBGene00008119", "Q22469", "WBGene00011758", "G5ECL3", "WBGene00004188", "Q19335", "WBGene00008683", "Q95Y51", "WBGene00004891", "G5EBY6", 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demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10505377", "species_10507168" ], "products": [ "species_113550", "species_10509981", "species_10509975" ], "modifiers": [ [ "species_10505377", "catalyst" ] ], "additional_components": [ "Q9NEW6", "WBGene00004700", "O62185", "WBGene00004706", "Q21155", "WBGene00004388", "Q8WQF3", "WBGene00004882", "Q21559", "WBGene00000122", "Q9BL61", "WBGene00022029", "G5EDE4", "WBGene00012343", "Q21832", "WBGene00004387", "P49029", "WBGene00003123", "P34498", "WBGene00003389", "P90978", "WBGene00006697", "Q18409", "WBGene00004703", "O44729", "WBGene00018625", "Q9U2U0", "WBGene00006698", "Q23120", "WBGene00004699", "Q09511", "WBGene00004701", "P91867", "WBGene00009341", "C2BR94", "WBGene00021311", "Q9N5E3", "WBGene00020172", "Q18033", "WBGene00015813", "Q9U3S3", "WBGene00007195", "Q9N3G0", "WBGene00021813", "Q18212", "WBGene00001840", "species_29358", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "Q21278", "WBGene00010629", "Q9U757", "WBGene00003836", "Q9XVS8", "WBGene00003835", "Q9XVS7", "WBGene00003834", "Q9U757", "WBGene00003836", "Q9XVS8", "WBGene00003835", "Q9XVS7", "WBGene00003834", "O62185", "WBGene00004706", "Q21155", "WBGene00004388", "Q8WQF3", "WBGene00004882", "Q21559", "WBGene00000122", "Q9BL61", "WBGene00022029", "G5EDE4", "WBGene00012343", "Q21832", "WBGene00004387", "P49029", "WBGene00003123", "Q9NEW6", "WBGene00004700", "P34498", "WBGene00003389", "P90978", "WBGene00006697", "Q18409", "WBGene00004703", "O44729", "WBGene00018625", "Q9U2U0", "WBGene00006698", "Q23120", "WBGene00004699", "Q09511", "WBGene00004701", "P91867", "WBGene00009341", "C2BR94", "WBGene00021311", "Q9N5E3", "WBGene00020172", "Q18033", "WBGene00015813", "Q9U3S3", "WBGene00007195", "Q9N3G0", "WBGene00021813", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "Q21278", "WBGene00010629", "Q18212", "WBGene00001840", "species_113582", "Q9NEW6", "WBGene00004700", "O62185", "WBGene00004706", "Q21155", "WBGene00004388", "Q8WQF3", "WBGene00004882", "Q21559", "WBGene00000122", "Q9BL61", "WBGene00022029", "G5EDE4", "WBGene00012343", "Q21832", "WBGene00004387", "P49029", "WBGene00003123", "P34498", "WBGene00003389", "P90978", "WBGene00006697", "Q18409", "WBGene00004703", "O44729", "WBGene00018625", "Q9U2U0", "WBGene00006698", "Q23120", "WBGene00004699", "Q09511", "WBGene00004701", "P91867", "WBGene00009341", "C2BR94", "WBGene00021311", "Q9N5E3", "WBGene00020172", "Q18033", "WBGene00015813", "Q9U3S3", "WBGene00007195", "Q9N3G0", "WBGene00021813", "Q18212", "WBGene00001840", "species_29358", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "Q21278", "WBGene00010629" ] }, "reaction_10505380": { "compartment": "compartment_7660", "id": "reaction_10505380", "reactome": "R-CEL-72185", "name": "mRNA polyadenylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10505370" ], "products": [ "species_10505197", "species_10505192", "species_10505156", "species_10505377" ], "modifiers": [ [ "species_10505192", "catalyst" ] ], "additional_components": [ "Q9NEW6", "WBGene00004700", "O62185", "WBGene00004706", "Q21155", "WBGene00004388", "Q8WQF3", "WBGene00004882", "Q21559", "WBGene00000122", "Q9BL61", "WBGene00022029", "G5EDE4", "WBGene00012343", "Q21832", "WBGene00004387", "P49029", "WBGene00003123", "P34498", "WBGene00003389", "Q95PY8", "WBGene00013460", "U4PCM1", "WBGene00011051", "Q9N4C2", "WBGene00022301", "Q7YTG9", "WBGene00044329", "O17403", "WBGene00017313", "O16929", "WBGene00017797", "P90978", "WBGene00006697", "Q18409", "WBGene00004703", "Q09995", "WBGene00011791", "Q9U2P3", "WBGene00012528", "G5EBX5", "WBGene00009658", "O44729", "WBGene00018625", "Q9U2U0", "WBGene00006698", "Q93233", "WBGene00003904", "Q23120", "WBGene00004699", "Q09511", "WBGene00004701", "P91867", "WBGene00009341", "C2BR94", "WBGene00021311", "Q9N5E3", "WBGene00020172", "Q18033", "WBGene00015813", "Q9U3S3", "WBGene00007195", "Q9N3G0", "WBGene00021813", "Q18212", "WBGene00001840", "species_29358", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "Q21278", "WBGene00010629", "WBGene00003904", "Q09995", "WBGene00011791", "Q9U2P3", "WBGene00012528", "G5EBX5", "WBGene00009658", "Q95PY8", "WBGene00013460", "U4PCM1", "WBGene00011051", "Q9N4C2", "WBGene00022301", "Q7YTG9", "WBGene00044329", "O17403", "WBGene00017313", "O16929", "WBGene00017797", "Q9NEW6", "WBGene00004700", "O62185", "WBGene00004706", "Q21155", "WBGene00004388", "Q8WQF3", "WBGene00004882", "Q21559", "WBGene00000122", "Q9BL61", "WBGene00022029", "G5EDE4", "WBGene00012343", "Q21832", "WBGene00004387", "P49029", "WBGene00003123", "P34498", "WBGene00003389", "P90978", "WBGene00006697", "Q18409", "WBGene00004703", "O44729", "WBGene00018625", "Q9U2U0", "WBGene00006698", "Q23120", "WBGene00004699", "Q09511", "WBGene00004701", "P91867", "WBGene00009341", "C2BR94", "WBGene00021311", "Q9N5E3", "WBGene00020172", "Q18033", "WBGene00015813", "Q9U3S3", "WBGene00007195", "Q9N3G0", "WBGene00021813", "Q18212", "WBGene00001840", "species_29358", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "Q21278", "WBGene00010629", "Q09995", "WBGene00011791", "Q9U2P3", "WBGene00012528", "G5EBX5", "WBGene00009658" ] }, "reaction_10505375": { "compartment": "compartment_7660", "id": "reaction_10505375", "reactome": "R-CEL-72180", "name": "Cleavage of mRNA at the 3'-end", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10505368" ], "products": [ "species_10505213", "species_10505370", "species_10505225", "species_10505175" ], "modifiers": [ [ "species_10505372", "catalyst" ] ], "additional_components": [ "Q9NEW6", "WBGene00004700", "O62185", "WBGene00004706", "Q21155", "WBGene00004388", "Q8WQF3", "WBGene00004882", "Q21559", "WBGene00000122", "Q9BL61", "WBGene00022029", "G5EDE4", "WBGene00012343", "Q21832", "WBGene00004387", "P49029", "WBGene00003123", "P34498", "WBGene00003389", "P90978", "WBGene00006697", "Q18409", "WBGene00004703", "O44729", "WBGene00018625", "Q9U2U0", "WBGene00006698", "Q95PY8", "WBGene00013460", "U4PCM1", "WBGene00011051", "Q9N4C2", "WBGene00022301", "Q7YTG9", "WBGene00044329", "O17403", "WBGene00017313", "O16929", "WBGene00017797", "O45577", "WBGene00000774", "Q19864", "WBGene00000773", "Q19866", "WBGene00006307", "Q09995", "WBGene00011791", "Q9U2P3", "WBGene00012528", "G5EBX5", "WBGene00009658", "P52874", "WBGene00010304", "Q09345", "WBGene00020092", "Q93233", "WBGene00003904", "Q93716", "WBGene00009668", "C1P629", "WBGene00008362", "Q23120", "WBGene00004699", "Q09511", "WBGene00004701", "P91867", "WBGene00009341", "C2BR94", "WBGene00021311", "Q9N5E3", "WBGene00020172", "Q18033", "WBGene00015813", "Q9U3S3", "WBGene00007195", "Q9N3G0", "WBGene00021813", "Q18212", "WBGene00001840", "species_29358", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "Q21278", "WBGene00010629", "Q93716", "WBGene00009668", "C1P629", "WBGene00008362", "Q9NEW6", "WBGene00004700", "O62185", "WBGene00004706", "Q21155", "WBGene00004388", "Q8WQF3", "WBGene00004882", "Q21559", "WBGene00000122", "Q9BL61", "WBGene00022029", "G5EDE4", "WBGene00012343", "Q21832", "WBGene00004387", "P49029", "WBGene00003123", "P34498", "WBGene00003389", "Q95PY8", "WBGene00013460", "U4PCM1", "WBGene00011051", "Q9N4C2", "WBGene00022301", "Q7YTG9", "WBGene00044329", "O17403", "WBGene00017313", "O16929", "WBGene00017797", "P90978", "WBGene00006697", "Q18409", "WBGene00004703", "Q09995", "WBGene00011791", "Q9U2P3", "WBGene00012528", "G5EBX5", "WBGene00009658", "O44729", "WBGene00018625", "Q9U2U0", "WBGene00006698", "Q93233", "WBGene00003904", "Q23120", "WBGene00004699", "Q09511", "WBGene00004701", "P91867", "WBGene00009341", "C2BR94", "WBGene00021311", "Q9N5E3", "WBGene00020172", "Q18033", "WBGene00015813", "Q9U3S3", "WBGene00007195", "Q9N3G0", "WBGene00021813", "Q18212", "WBGene00001840", "species_29358", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "Q21278", "WBGene00010629", "P52874", "WBGene00010304", "Q09345", "WBGene00020092", "O45577", "WBGene00000774", "Q19864", "WBGene00000773", "Q19866", "WBGene00006307", "P52874", "WBGene00010304", "Q09345", "WBGene00020092", "Q93716", "WBGene00009668", "C1P629", "WBGene00008362" ] }, "reaction_10553705": { "compartment": "compartment_18730", "id": "reaction_10553705", "reactome": "R-CEL-5625426", "name": "Retrograde IFT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10553703" ], "products": [ "species_10553699" ], "modifiers": [], "additional_components": [ "species_29420", "species_29438", "Q19542", "WBGene00000485", "Q18263", "WBGene00016165", "Q19119", "WBGene00006960", "Q7YTJ8", "WBGene00012425", "A0AAC1", "WBGene00012424", "Q21557", "WBGene00010888", "Q22799", "WBGene00001005", "Q65XS9", "WBGene00043067", "Q22752", "WBGene00012004", "Q20255", "WBGene00022696", "G5ECZ4", "WBGene00001118", "Q18859", "WBGene00016935", "G5EFW7", "WBGene00000906", "P90757", "WBGene00000490", "Q0G838", "WBGene00001122", "G5EDF6", "WBGene00003886", "Q93833", "WBGene00000492", "A0A2C9C2L6", "WBGene00016005", "G5EGF0", "WBGene00000484", "A8DYR7", "WBGene00017973", "G5ED37", "WBGene00003885", "Q9XUC2", "WBGene00012132", "Q17595", "WBGene00001127", "Q6I6D4", "WBGene00001119", "Q95QT8", "WBGene00001129", "Q8I7G4", "WBGene00001117", "Q22830", "WBGene00003883", "Q8TA52", "WBGene00022465", "Q965T6", "WBGene00002230", "G5EEE6", "WBGene00002182", "Q19633", "WBGene00002222", "Q65XS9", "WBGene00043067", "Q7YTJ8", "WBGene00012425", "A0AAC1", "WBGene00012424", "Q21557", "WBGene00010888", "Q22799", "WBGene00001005", "Q22752", "WBGene00012004", "Q18263", "WBGene00016165", "Q19119", "WBGene00006960", "Q19542", "WBGene00000485", "species_29420", "species_29438", "Q19633", "WBGene00002222", "Q965T6", "WBGene00002230", "G5EEE6", "WBGene00002182", "Q17595", "WBGene00001127", "Q93833", "WBGene00000492", "Q6I6D4", "WBGene00001119", "A0A2C9C2L6", "WBGene00016005", "Q95QT8", "WBGene00001129", "G5EGF0", "WBGene00000484", "Q8I7G4", "WBGene00001117", "Q22830", "WBGene00003883", "A8DYR7", "WBGene00017973", "G5ED37", "WBGene00003885", "Q0G838", "WBGene00001122", "Q9XUC2", "WBGene00012132", "G5EDF6", "WBGene00003886", "Q8TA52", "WBGene00022465", "Q20255", "WBGene00022696", "G5EFW7", "WBGene00000906", "G5ECZ4", "WBGene00001118", "Q18859", "WBGene00016935", "P90757", "WBGene00000490" ] }, "reaction_10552842": { "compartment": "compartment_20699", "id": "reaction_10552842", "reactome": "R-CEL-5617828", "name": "TRIP11:IFT20 dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10552840" ], "products": [ "species_10552838", "species_10552833" ], "modifiers": [], "additional_components": [ "Q8TA52", "WBGene00022465", "D0Z5P0", "WBGene00013730", "WBGene00013730", "WBGene00022465" ] }, "reaction_10553695": { "compartment": "compartment_18730", "id": "reaction_10553695", "reactome": "R-CEL-5625416", "name": "Anterograde IFT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10553659" ], "products": [ "species_10553693" ], "modifiers": [], "additional_components": [ "Q65XS9", "WBGene00043067", "Q7YTJ8", "WBGene00012425", "A0AAC1", "WBGene00012424", "Q21557", "WBGene00010888", "Q22799", "WBGene00001005", "Q22752", "WBGene00012004", "Q18263", "WBGene00016165", "Q19119", "WBGene00006960", "Q19542", "WBGene00000485", "Q17595", "WBGene00001127", "Q93833", "WBGene00000492", "Q6I6D4", "WBGene00001119", "A0A2C9C2L6", "WBGene00016005", "Q95QT8", "WBGene00001129", "G5EGF0", "WBGene00000484", "Q8I7G4", "WBGene00001117", "Q22830", "WBGene00003883", "A8DYR7", "WBGene00017973", "G5ED37", "WBGene00003885", "Q0G838", "WBGene00001122", "Q9XUC2", "WBGene00012132", "G5EDF6", "WBGene00003886", "Q8TA52", "WBGene00022465", "species_29420", "species_29438", "Q19633", "WBGene00002222", "Q965T6", "WBGene00002230", "G5EEE6", "WBGene00002182", "Q20255", "WBGene00022696", "G5EFW7", "WBGene00000906", "G5ECZ4", "WBGene00001118", "Q18859", "WBGene00016935", "P90757", "WBGene00000490", "Q20255", "WBGene00022696", "G5ECZ4", "WBGene00001118", "Q18859", "WBGene00016935", "G5EFW7", "WBGene00000906", "P90757", "WBGene00000490", "Q19542", "WBGene00000485", "Q18263", "WBGene00016165", "Q19119", "WBGene00006960", "Q7YTJ8", "WBGene00012425", "A0AAC1", "WBGene00012424", "Q21557", "WBGene00010888", "Q22799", "WBGene00001005", "Q65XS9", "WBGene00043067", "Q22752", "WBGene00012004", "species_29420", "species_29438", "Q965T6", "WBGene00002230", "G5EEE6", "WBGene00002182", "Q19633", "WBGene00002222", "Q0G838", "WBGene00001122", "G5EDF6", "WBGene00003886", "Q93833", "WBGene00000492", "A0A2C9C2L6", "WBGene00016005", "G5EGF0", "WBGene00000484", "A8DYR7", "WBGene00017973", "G5ED37", "WBGene00003885", "Q9XUC2", "WBGene00012132", "Q17595", "WBGene00001127", "Q6I6D4", "WBGene00001119", "Q95QT8", "WBGene00001129", "Q8I7G4", "WBGene00001117", "Q22830", "WBGene00003883", "Q8TA52", "WBGene00022465" ] }, "reaction_10565360": { "compartment": "compartment_7660", "id": "reaction_10565360", "reactome": "R-CEL-8852131", "name": "Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502318", "species_29358", "species_10565305" ], "products": [ "species_10565307", "species_113541" ], "modifiers": [], "additional_components": [ "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "Q27481", "WBGene00006699", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "P49632", "WBGene00006728", "Q27481", "WBGene00006699" ] }, "reaction_10565363": { "compartment": "compartment_70101", "id": "reaction_10565363", "reactome": "R-CEL-8852132", "name": "Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10565228", "species_113592", "species_10502375" ], "products": [ "species_111294", "species_10565258" ], "modifiers": [ [ "species_10565228", "catalyst" ] ], "additional_components": [ "Q27481", "WBGene00006699", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "P49632", "WBGene00006728", "Q27481", "WBGene00006699", "Q27481", "WBGene00006699", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727" ] }, "reaction_10565303": { "compartment": "compartment_70101", "id": "reaction_10565303", "reactome": "R-CEL-8852129", "name": "UBA1 conjugates ubiquitin to cytosolic E2 enzymes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10565258", "species_10565226" ], "products": [ "species_10565260", "species_10565301" ], "modifiers": [], "additional_components": [ "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "P49632", "WBGene00006728", "Q27481", "WBGene00006699", "P35129", "WBGene00002344", "P91853", "WBGene00006732", "Q17720", "WBGene00006717", "Q9U1Q1", "WBGene00006709", "Q95XN7", "WBGene00006702", "Q9TZ69", "WBGene00006715", "Q9N2W9", "WBGene00006705", "H8W3X5", "WBGene00219376", "Q21633", "WBGene00006713", "P34477", "WBGene00006704", "Q93571", "WBGene00006720", "Q27481", "WBGene00006699", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "P49632", "WBGene00006728", "P34477", "WBGene00006704", "Q9U1Q1", "WBGene00006709", "Q9N2W9", "WBGene00006705", "Q9TZ69", "WBGene00006715", "P35129", "WBGene00002344", "P91853", "WBGene00006732", "Q17720", "WBGene00006717", "H8W3X5", "WBGene00219376", "Q21633", "WBGene00006713", "Q95XN7", "WBGene00006702", "Q93571", "WBGene00006720", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727" ] }, "reaction_10565366": { "compartment": "compartment_70101", "id": "reaction_10565366", "reactome": "R-CEL-8852133", "name": "UBA1 conjugates ubiquitin to UBA1 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10565260" ], "products": [ "species_10565228", "species_76577" ], "modifiers": [ [ "species_10565260", "catalyst" ] ], "additional_components": [ "Q27481", "WBGene00006699", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "P49632", "WBGene00006728", "Q27481", "WBGene00006699", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "Q27481", "WBGene00006699", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "P49632", "WBGene00006728" ] }, "reaction_10565369": { "compartment": "compartment_70101", "id": "reaction_10565369", "reactome": "R-CEL-8852134", "name": "UBA1 adenylates ubiquitin in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10502375", "species_10531318" ], "products": [ "species_111294", "species_10565260" ], "modifiers": [ [ "species_10531318", "catalyst" ] ], "additional_components": [ "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "WBGene00006699", "Q27481", "WBGene00006699", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "P49632", "WBGene00006728", "WBGene00006699" ] }, "reaction_10565432": { "compartment": "compartment_70101", "id": "reaction_10565432", "reactome": "R-CEL-8853514", "name": "UCHL3,USP7,USP9X cleaves UBA52 yielding ubiquitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10565425" ], "products": [ "species_10502349", "species_10505892" ], "modifiers": [ [ "species_10565429", "catalyst" ] ], "additional_components": [ "WBGene00006725", "WBGene00006725", "WBGene00006725", "Q7JKC3", "WBGene00010406", "Q9UAV3", "WBGene00006721" ] }, "reaction_10565224": { "compartment": "compartment_7660", "id": "reaction_10565224", "reactome": "R-CEL-8852128", "name": "UBA1 adenylates ubiquitin in the nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502318", "species_29358", "species_10565179" ], "products": [ "species_10565222", "species_113541" ], "modifiers": [], "additional_components": [ "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "WBGene00006699", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "P49632", "WBGene00006728", "Q27481", "WBGene00006699" ] }, "reaction_10565371": { "compartment": "compartment_7660", "id": "reaction_10565371", "reactome": "R-CEL-8852136", "name": "UBA1 conjugates ubiquitin to UBA1 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10565222" ], "products": [ "species_164121", "species_10565305" ], "modifiers": [], "additional_components": [ "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "P49632", "WBGene00006728", "Q27481", "WBGene00006699", "Q27481", "WBGene00006699", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725" ] }, "reaction_10565358": { "compartment": "compartment_7660", "id": "reaction_10565358", "reactome": "R-CEL-8852130", "name": "UBA1 conjugates ubiquitin to nuclear E2 enzymes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10565326", "species_10565307" ], "products": [ "species_10565356", "species_10565222" ], "modifiers": [], "additional_components": [ "H8W3X5", "WBGene00219376", "P35129", "WBGene00002344", "P91853", "WBGene00006732", "Q17720", "WBGene00006717", "Q21633", "WBGene00006713", "Q20872", "WBGene00006731", "Q95XN7", "WBGene00006702", "Q9XWF6", "WBGene00006711", "P52478", "WBGene00006701", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "P49632", "WBGene00006728", "Q27481", "WBGene00006699", "Q95XN7", "WBGene00006702", "H8W3X5", "WBGene00219376", "P52478", "WBGene00006701", "Q21633", "WBGene00006713", "Q20872", "WBGene00006731", "Q9XWF6", "WBGene00006711", "P35129", "WBGene00002344", "P91853", "WBGene00006732", "Q17720", "WBGene00006717", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "P49632", "WBGene00006728", "Q27481", "WBGene00006699" ] }, "reaction_10532323": { "compartment": "compartment_70101", "id": "reaction_10532323", "reactome": "R-CEL-1247645", "name": "RHAG transports CO2 from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113528" ], "products": [ "species_1237009" ], "modifiers": [ [ "species_10524631", "catalyst" ] ], "additional_components": [ "Q17463", "WBGene00004359", "Q22947", "WBGene00004358" ] }, "reaction_10534719": { "compartment": "compartment_70101", "id": "reaction_10534719", "reactome": "R-CEL-1475436", "name": "CA1:Zn2+,CA2:Zn2+ dehydrate HCO3- to CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_111627" ], "products": [ "species_29356", "species_113528" ], "modifiers": [ [ "species_10534714", "catalyst" ] ], "additional_components": [ "O02637", "WBGene00000284", "Q10462", "WBGene00000283", "Q21614", "WBGene00000282", "Q27504", "WBGene00000281", "species_216785" ] }, "reaction_10568241": { "compartment": "compartment_70101", "id": "reaction_10568241", "reactome": "R-CEL-8936849", "name": "AHR:2xHSP90:AIP:PTGES3 binds TCDD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8936852", "species_10568237" ], "products": [ "species_10568239" ], "modifiers": [], "additional_components": [ "Q18688", "WBGene00000915", "O44712", "WBGene00000096", "Q18888", "WBGene00016966", "Q23280", "WBGene00022599", "Q18688", "WBGene00000915", "O44712", "WBGene00000096", "Q18888", "WBGene00016966", "Q23280", "WBGene00022599", "species_8936852" ] }, "reaction_10568289": { "compartment": "compartment_7660", "id": "reaction_10568289", "reactome": "R-CEL-8937191", "name": "AHR:TCDD:2xHSP90AB1:AIP:PTGES3 dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10568281" ], "products": [ "species_10556878", "species_10568287" ], "modifiers": [], "additional_components": [ "Q18688", "WBGene00000915", "Q18888", "WBGene00016966", "Q23280", "WBGene00022599", "O44712", "WBGene00000096", "species_8936852", "species_8936852", "O44712", "WBGene00000096", "Q18688", "WBGene00000915", "Q18888", "WBGene00016966", "Q23280", "WBGene00022599" ] }, "reaction_10568243": { "compartment": "compartment_70101", "id": "reaction_10568243", "reactome": "R-CEL-8936851", "name": "AHRR binds ARNT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10532219", "species_10556884" ], "products": [ "species_10556886" ], "modifiers": [], "additional_components": [ "WBGene00000095", "WBGene00000096", "O44712", "WBGene00000096", "O02219", "WBGene00000095" ] }, "reaction_10568283": { "compartment": "compartment_70101", "id": "reaction_10568283", "reactome": "R-CEL-8937169", "name": "AHR:TCDD:2xHSP90AB1:AIP:PTGES3 translocates from cytosol to nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10568239" ], "products": [ "species_10568281" ], "modifiers": [], "additional_components": [ "Q18688", "WBGene00000915", "O44712", "WBGene00000096", "Q18888", "WBGene00016966", "Q23280", "WBGene00022599", "species_8936852", "Q18688", "WBGene00000915", "Q18888", "WBGene00016966", "Q23280", "WBGene00022599", "O44712", "WBGene00000096", "species_8936852" ] }, "reaction_10568285": { "compartment": "compartment_7660", "id": "reaction_10568285", "reactome": "R-CEL-8937177", "name": "AHR:TCDD binds ARNT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10556878", "species_10532219" ], "products": [ "species_10556882" ], "modifiers": [], "additional_components": [ "species_8936852", "O44712", "WBGene00000096", "WBGene00000095", "O02219", "WBGene00000095", "species_8936852", "O44712", "WBGene00000096" ] }, "reaction_10569050": { "compartment": "compartment_7660", "id": "reaction_10569050", "reactome": "R-CEL-8951676", "name": "RUNX3 binds TEADs and YAP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10566205", "species_10542185" ], "products": [ "species_10569048" ], "modifiers": [], "additional_components": [ "WBGene00004393", "Q19849", "WBGene00001208", "Q19404", "WBGene00008748", "Q19849", "WBGene00001208", "Q19404", "WBGene00008748", "G5EFQ5", "WBGene00004393" ] }, "reaction_10569036": { "compartment": "compartment_7660", "id": "reaction_10569036", "reactome": "R-CEL-8951428", "name": "RUNX3 binds CTNNB1:TCF7L2,(LEF1,TCF7L1,TCF7)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10566205", "species_10547172" ], "products": [ "species_10569034" ], "modifiers": [], "additional_components": [ "WBGene00004393", "Q10666", "WBGene00004077", "O44326", "WBGene00001979", "Q10666", "WBGene00004077", "O44326", "WBGene00001979", "G5EFQ5", "WBGene00004393" ] }, "reaction_10527860": { "compartment": "compartment_20699", "id": "reaction_10527860", "reactome": "R-CEL-741450", "name": "SLC35A3 exchanges UDP-GlcNAc for UMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_735698", "species_162756" ], "products": [ "species_914003", "species_109402" ], "modifiers": [ [ "species_10527857", "catalyst" ] ], "additional_components": [ "WBGene00015404" ] }, "reaction_10527876": { "compartment": "compartment_20699", "id": "reaction_10527876", "reactome": "R-CEL-742354", "name": "SLC35B4 mediates the transport of UDP-N-acetylglucosamine into the Golgi lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_162756" ], "products": [ "species_914003" ], "modifiers": [ [ "species_10527873", "catalyst" ] ], "additional_components": [ "WBGene00017480" ] }, "reaction_10527879": { "compartment": "compartment_20699", "id": "reaction_10527879", "reactome": "R-CEL-742373", "name": "SLC35B4 mediates the transport of UDP-xylose into the Golgi lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_742353" ], "products": [ "species_742361" ], "modifiers": [ [ "species_10527873", "catalyst" ] ], "additional_components": [ "WBGene00017480" ] }, "reaction_10527832": { "compartment": "compartment_20699", "id": "reaction_10527832", "reactome": "R-CEL-727807", "name": "SLC35A1 exchanges CMP-Neu5Ac for CMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_727810", "species_4085435" ], "products": [ "species_727815", "species_109395" ], "modifiers": [ [ "species_10527829", "catalyst" ] ], "additional_components": [ "Q93890", "WBGene00005153", "O01879", "WBGene00022577", "O02345", "WBGene00014139", "Q02334", "WBGene00022721" ] }, "reaction_10527868": { "compartment": "compartment_20699", "id": "reaction_10527868", "reactome": "R-CEL-742345", "name": "SLC35C1 transport UDP-Fuc from cytosol to Golgi lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_742368" ], "products": [ "species_205683" ], "modifiers": [ [ "species_10527865", "catalyst" ] ], "additional_components": [ "WBGene00008237" ] }, "reaction_10527884": { "compartment": "compartment_20699", "id": "reaction_10527884", "reactome": "R-CEL-744230", "name": "SLC35D2 mediates the antiport of GDP-mannose in exchange for GMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_162860", "species_744239" ], "products": [ "species_113578", "species_744233" ], "modifiers": [ [ "species_10527881", "catalyst" ] ], "additional_components": [ "WBGene00005025" ] }, "reaction_10527837": { "compartment": "compartment_20699", "id": "reaction_10527837", "reactome": "R-CEL-735702", "name": "SLC35A2 exchanges UDP-Gal, UDP-GalNAc for UMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_735698", "species_735692" ], "products": [ "species_109402", "species_735691" ], "modifiers": [ [ "species_10527834", "catalyst" ] ], "additional_components": [ "species_735700", "species_1981137", "species_1981137", "species_735700", "WBGene00005153" ] }, "reaction_10527886": { "compartment": "compartment_20699", "id": "reaction_10527886", "reactome": "R-CEL-744231", "name": "SLC35D2 exchanges UDP-sugars for UMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_744229", "species_735698" ], "products": [ "species_109402", "species_744234" ], "modifiers": [ [ "species_10527881", "catalyst" ] ], "additional_components": [ "species_173594", "species_914003", "species_173594", "species_914003", "WBGene00005025" ] }, "reaction_10508358": { "compartment": "compartment_7660", "id": "reaction_10508358", "reactome": "R-CEL-77613", "name": "Binding of ADAR2 homodimer to dsRNA duplex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_75086", "species_10508354" ], "products": [ "species_10508356" ], "modifiers": [], "additional_components": [ "Q22618", "WBGene00000080", "Q22618", "WBGene00000080" ] }, "reaction_10508826": { "compartment": "compartment_7660", "id": "reaction_10508826", "reactome": "R-CEL-111237", "name": "Formation of ADAR1 homodimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10507129" ], "products": [ "species_10507131" ], "modifiers": [], "additional_components": [ "Q93412", "WBGene00008397", "Q9U3D6", "WBGene00000079", "Q93412", "WBGene00008397", "Q9U3D6", "WBGene00000079" ] }, "reaction_10508828": { "compartment": "compartment_7660", "id": "reaction_10508828", "reactome": "R-CEL-111238", "name": "Formation of ADAR2 homodimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508352" ], "products": [ "species_10508354" ], "modifiers": [], "additional_components": [ "WBGene00000080", "Q22618", "WBGene00000080" ] }, "reaction_10507135": { "compartment": "compartment_7660", "id": "reaction_10507135", "reactome": "R-CEL-75090", "name": "Binding of ADAR1 homodimer to dsRNA duplex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_75086", "species_10507131" ], "products": [ "species_10507133" ], "modifiers": [], "additional_components": [ "Q93412", "WBGene00008397", "Q9U3D6", "WBGene00000079", "Q93412", "WBGene00008397", "Q9U3D6", "WBGene00000079" ] }, "reaction_10508368": { "compartment": "compartment_7660", "id": "reaction_10508368", "reactome": "R-CEL-77615", "name": "Deamination at C6 position of adenosine in Editosome (ADAR2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10508356" ], "products": [ "species_10508365", "species_76230" ], "modifiers": [ [ "species_10508354", "catalyst" ] ], "additional_components": [ "Q22618", "WBGene00000080", "Q22618", "WBGene00000080", "Q22618", "WBGene00000080" ] }, "reaction_10508363": { "compartment": "compartment_7660", "id": "reaction_10508363", "reactome": "R-CEL-77614", "name": "Deamination at C6 position of adenosine in Editosome (ADAR1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10507133" ], "products": [ "species_10508360", "species_76230" ], "modifiers": [ [ "species_10507131", "catalyst" ] ], "additional_components": [ "Q93412", "WBGene00008397", "Q9U3D6", "WBGene00000079", "Q93412", "WBGene00008397", "Q9U3D6", "WBGene00000079", "Q93412", "WBGene00008397", "Q9U3D6", "WBGene00000079" ] }, "reaction_10508608": { "compartment": "compartment_70101", "id": "reaction_10508608", "reactome": "R-CEL-109864", "name": "Dissociation of p-T,Y-MAPK1:p-S,T-MAP2K2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508601" ], "products": [ "species_10508573", "species_10508599" ], "modifiers": [], "additional_components": [ "P39745", "WBGene00003401", "Q10664", "WBGene00003186", "WBGene00003186", "WBGene00003401" ] }, "reaction_10508579": { "compartment": "compartment_70101", "id": "reaction_10508579", "reactome": "R-CEL-109858", "name": "MAP2K2 binds MAPK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508575", "species_10508573" ], "products": [ "species_10508577" ], "modifiers": [], "additional_components": [ "WBGene00003401", "WBGene00003186", "Q10664", "WBGene00003186", "P39745", "WBGene00003401" ] }, "reaction_10508604": { "compartment": "compartment_70101", "id": "reaction_10508604", "reactome": "R-CEL-109862", "name": "MAP2K2 phosphorylates MAPK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10508577" ], "products": [ "species_29370", "species_10508601" ], "modifiers": [ [ "species_10508577", "catalyst" ] ], "additional_components": [ "Q10664", "WBGene00003186", "P39745", "WBGene00003401", "P39745", "WBGene00003401", "Q10664", "WBGene00003186", "Q10664", "WBGene00003186", "P39745", "WBGene00003401" ] }, "reaction_10525426": { "compartment": "compartment_5460", "id": "reaction_10525426", "reactome": "R-CEL-449937", "name": "pyrophosphate + H2O => 2 orthophosphate [mitochondrial]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_159450", "species_113521" ], "products": [ "species_113548" ], "modifiers": [ [ "species_10525423", "catalyst" ], [ "species_109496", "catalyst" ] ], "additional_components": [ "Q18680", "WBGene00008149" ] }, "reaction_10504277": { "compartment": "compartment_70101", "id": "reaction_10504277", "reactome": "R-CEL-71732", "name": "pyrophosphate + H2O => 2 orthophosphate [cytosolic]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111294", "species_29356" ], "products": [ "species_29372" ], "modifiers": [ [ "species_10504274", "catalyst" ], [ "species_29926", "catalyst" ] ], "additional_components": [ "Q18680", "WBGene00008149" ] }, "reaction_10571313": { "compartment": "compartment_876", "id": "reaction_10571313", "reactome": "R-CEL-9017491", "name": "RHOJ GEFs activate RHOJ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10571305" ], "products": [ "species_29420", "species_10571303" ], "modifiers": [ [ "species_10531723", "catalyst" ] ], "additional_components": [ "O62422", "WBGene00012532", "Q05062", "WBGene00000390", "species_29420", "O62422", "WBGene00012532", "Q05062", "WBGene00000390", "species_29438", "WBGene00018520" ] }, "reaction_10571310": { "compartment": "compartment_876", "id": "reaction_10571310", "reactome": "R-CEL-9017488", "name": "RHOJ GAPs stimulate RHOJ GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10571303" ], "products": [ "species_29372", "species_10571305" ], "modifiers": [ [ "species_10571307", "catalyst" ] ], "additional_components": [ "O62422", "WBGene00012532", "Q05062", "WBGene00000390", "species_29438", "O62422", "WBGene00012532", "Q05062", "WBGene00000390", "species_29420", "O45611", "WBGene00010374", "H2KZV6", "WBGene00020209", "Q23130", "WBGene00012203" ] }, "reaction_10571008": { "compartment": "compartment_876", "id": "reaction_10571008", "reactome": "R-CEL-9013009", "name": "RHOA binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10571004", "species_10509488" ], "products": [ "species_10571006" ], "modifiers": [], "additional_components": [ "Q7JP75", "WBGene00000872", "Q19479", "WBGene00008848", "A0A4V0IKG6", "WBGene00007287", "G5EDU3", "WBGene00004040", "P92199", "WBGene00002694", "A0A4V0ILM7", "WBGene00009793", "D6VPA1", "WBGene00018976", "Q21025", "WBGene00019087", "Q9XVH4", "WBGene00019087", "Q17777", "WBGene00007409", "Q09994", "WBGene00019608", "O17772", "WBGene00003980", "Q22038", "WBGene00004357", "species_29438", "Q22038", "WBGene00004357", "species_29438", "Q7JP75", "WBGene00000872", "Q19479", "WBGene00008848", "A0A4V0IKG6", "WBGene00007287", "G5EDU3", "WBGene00004040", "P92199", "WBGene00002694", "A0A4V0ILM7", "WBGene00009793", "D6VPA1", "WBGene00018976", "Q21025", "WBGene00019087", "Q9XVH4", "WBGene00019087", "Q17777", "WBGene00007409", "Q09994", "WBGene00019608", "O17772", "WBGene00003980" ] }, "reaction_10570947": { "compartment": "compartment_70101", "id": "reaction_10570947", "reactome": "R-CEL-9012835", "name": "GDIs block activation of RHOA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509486", "species_10570939" ], "products": [ "species_10570945" ], "modifiers": [], "additional_components": [ "Q22038", "WBGene00004357", "species_29420", "WBGene00004356", "Q20496", "WBGene00004356", "Q22038", "WBGene00004357", "species_29420" ] }, "reaction_10570274": { "compartment": "compartment_70101", "id": "reaction_10570274", "reactome": "R-CEL-8980691", "name": "RHOA GEFs activate RHOA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10509486" ], "products": [ "species_29420", "species_10509488" ], "modifiers": [ [ "species_10570271", "catalyst" ] ], "additional_components": [ "Q22038", "WBGene00004357", "species_29420", "Q22038", "WBGene00004357", "species_29438", "G5EFE1", "WBGene00006468", "H2L0P5", "WBGene00022391", "O61528", "WBGene00006805", "A0A0K3AQN0", "WBGene00013682", "Q9U3P2", "WBGene00007750", "Q965J0", "WBGene00019487", "S6EZU2", "WBGene00006476", "Q45FX5", "WBGene00006887", "Q21653", "WBGene00019832", "H2KYI7", "WBGene00006496", "Q9U364", "WBGene00002297" ] }, "reaction_10570420": { "compartment": "compartment_70101", "id": "reaction_10570420", "reactome": "R-CEL-8981637", "name": "RHOA GAPs stimulate RHOA GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10509488" ], "products": [ "species_10509486", "species_29372" ], "modifiers": [ [ "species_10570417", "catalyst" ] ], "additional_components": [ "Q22038", "WBGene00004357", "species_29438", "Q22038", "WBGene00004357", "species_29420", "H2KZV6", "WBGene00020209", "O45611", "WBGene00010374", "Q20498", "WBGene00009800", "O01443", "WBGene00015303", "A0A0K3AW57", "Y75B7AL.4c", "U4PAK0", "WBGene00007064", "Q9XW53", "WBGene00013135", "Q20440", "WBGene00001559", "Q23130", "WBGene00012203", "G5EF80", "WBGene00014051" ] }, "reaction_10570951": { "compartment": "compartment_876", "id": "reaction_10570951", "reactome": "R-CEL-9013006", "name": "RHOA:GTP translocates to the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509488" ], "products": [ "species_10570949" ], "modifiers": [], "additional_components": [ "Q22038", "WBGene00004357", "species_29438", "Q22038", "WBGene00004357", "species_29438" ] }, "reaction_10571347": { "compartment": "compartment_876", "id": "reaction_10571347", "reactome": "R-CEL-9018747", "name": "RHOQ GEFs activate RHOQ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10571331" ], "products": [ "species_29420", "species_10553913" ], "modifiers": [ [ "species_10571344", "catalyst" ] ], "additional_components": [ "O62422", "WBGene00012532", "Q05062", "WBGene00000390", "species_29420", "O62422", "WBGene00012532", "Q05062", "WBGene00000390", "species_29438", "Q9U3P2", "WBGene00007750", "A0A0K3AS36", "Y116A8C.36d" ] }, "reaction_10571336": { "compartment": "compartment_70101", "id": "reaction_10571336", "reactome": "R-CEL-9018745", "name": "RHOQ GAPs stimulate RHOQ GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10553913" ], "products": [ "species_29372", "species_10571331" ], "modifiers": [ [ "species_10571333", "catalyst" ] ], "additional_components": [ "O62422", "WBGene00012532", "Q05062", "WBGene00000390", "species_29438", "O62422", "WBGene00012532", "Q05062", "WBGene00000390", "species_29420", "Q20440", "WBGene00001559", "H2KZV6", "WBGene00020209", "Q23130", "WBGene00012203" ] }, "reaction_10553928": { "compartment": "compartment_13949", "id": "reaction_10553928", "reactome": "R-CEL-5627072", "name": "RHOQ binds GOPC:CFTR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10553903", "species_10553892" ], "products": [ "species_10553905" ], "modifiers": [], "additional_components": [ "O62422", "WBGene00012532", "Q05062", "WBGene00000390", "species_29438", "Q19625", "WBGene00003412", "Q95QV2", "WBGene00000477", "O18302", "WBGene00014101", "Q19625", "WBGene00003412", "Q95QV2", "WBGene00000477", "O18302", "WBGene00014101", "O62422", "WBGene00012532", "Q05062", "WBGene00000390", "species_29438" ] }, "reaction_10571342": { "compartment": "compartment_70101", "id": "reaction_10571342", "reactome": "R-CEL-9018746", "name": "RHOQ binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10571338", "species_10553913" ], "products": [ "species_10571340" ], "modifiers": [], "additional_components": [ "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "Q20498", "WBGene00009800", "Q19253", "WBGene00017298", "Q9XUS7", "WBGene00010663", "O17772", "WBGene00003980", "O62422", "WBGene00012532", "Q05062", "WBGene00000390", "species_29438", "O62422", "WBGene00012532", "Q05062", "WBGene00000390", "species_29438", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "Q20498", "WBGene00009800", "Q19253", "WBGene00017298", "Q9XUS7", "WBGene00010663", "O17772", "WBGene00003980" ] }, "reaction_10571470": { "compartment": "compartment_876", "id": "reaction_10571470", "reactome": "R-CEL-9018836", "name": "RHOQ translocates to the Golgi-associated vesicle membranes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10553913" ], "products": [ "species_10553903" ], "modifiers": [], "additional_components": [ "O62422", "WBGene00012532", "Q05062", "WBGene00000390", "species_29438", "O62422", "WBGene00012532", "Q05062", "WBGene00000390", "species_29438" ] }, "reaction_10571361": { "compartment": "compartment_876", "id": "reaction_10571361", "reactome": "R-CEL-9018754", "name": "GDIs bind RHOH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10571357", "species_10570939" ], "products": [ "species_10571359" ], "modifiers": [], "additional_components": [ "Q03206", "ced-10", "Q94124", "WBGene00004287", "Q9BL44", "WBGene00022177", "species_29438", "WBGene00004356", "Q20496", "WBGene00004356", "Q03206", "ced-10", "Q94124", "WBGene00004287", "Q9BL44", "WBGene00022177", "species_29438" ] }, "reaction_10571393": { "compartment": "compartment_876", "id": "reaction_10571393", "reactome": "R-CEL-9018758", "name": "RHOH binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10571389", "species_10571357" ], "products": [ "species_10571391" ], "modifiers": [], "additional_components": [ "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "G5EFU0", "WBGene00006443", "Q18462", "WBGene00016416", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "G5ECJ6", "WBGene00000812", "Q03206", "ced-10", "Q94124", "WBGene00004287", "Q9BL44", "WBGene00022177", "species_29438", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "G5EFU0", "WBGene00006443", "Q18462", "WBGene00016416", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "G5ECJ6", "WBGene00000812", "Q03206", "ced-10", "Q94124", "WBGene00004287", "Q9BL44", "WBGene00022177", "species_29438" ] }, "reaction_10571363": { "compartment": "compartment_876", "id": "reaction_10571363", "reactome": "R-CEL-9018756", "name": "RHOH binds GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10571355" ], "products": [ "species_10571357" ], "modifiers": [], "additional_components": [ "Q03206", "ced-10", "Q94124", "WBGene00004287", "Q9BL44", "WBGene00022177", "Q03206", "ced-10", "Q94124", "WBGene00004287", "Q9BL44", "WBGene00022177", "species_29438" ] }, "reaction_10571418": { "compartment": "compartment_876", "id": "reaction_10571418", "reactome": "R-CEL-9018766", "name": "RHOU binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10571400", "species_10571414" ], "products": [ "species_10571416" ], "modifiers": [], "additional_components": [ "Q19739", "WBGene00009059", "species_29438", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "G5EFU0", "WBGene00006443", "Q20498", "WBGene00009800", "Q95PX0", "WBGene00006410", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "G5EFU0", "WBGene00006443", "Q20498", "WBGene00009800", "Q95PX0", "WBGene00006410", "Q19739", "WBGene00009059", "species_29438" ] }, "reaction_10571423": { "compartment": "compartment_876", "id": "reaction_10571423", "reactome": "R-CEL-9018768", "name": "RHOU auto-activates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10571420" ], "products": [ "species_29420", "species_10571400" ], "modifiers": [ [ "species_10571420", "catalyst" ] ], "additional_components": [ "Q19739", "WBGene00009059", "species_29420", "Q19739", "WBGene00009059", "species_29438", "Q19739", "WBGene00009059", "species_29420" ] }, "reaction_10571105": { "compartment": "compartment_876", "id": "reaction_10571105", "reactome": "R-CEL-9013147", "name": "RAC1 GDIs block activation of RAC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10570939", "species_10541992" ], "products": [ "species_10571103" ], "modifiers": [], "additional_components": [ "WBGene00004356", "species_29420", "Q03206", "ced-10", "Q20496", "WBGene00004356", "species_29420", "Q03206", "ced-10" ] }, "reaction_10573125": { "compartment": "compartment_876", "id": "reaction_10573125", "reactome": "R-CEL-9691168", "name": "RAC1 translocates to the endoplasmic reticulum membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509457" ], "products": [ "species_10573123" ], "modifiers": [], "additional_components": [ "species_29438", "Q03206", "ced-10", "Q03206", "ced-10", "species_29438" ] }, "reaction_10571067": { "compartment": "compartment_876", "id": "reaction_10571067", "reactome": "R-CEL-9013144", "name": "RAC1 GAPs stimulate RAC1 GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10509457" ], "products": [ "species_29372", "species_10541992" ], "modifiers": [ [ "species_10571064", "catalyst" ] ], "additional_components": [ "species_29438", "Q03206", "ced-10", "species_29420", "Q03206", "ced-10", "P34288", "WBGene00015418", "Q9XVI0", "WBGene00011970", "P46941", "WBGene00008006", "Q20498", "WBGene00009800", "U4PAK0", "WBGene00007064", "Q9XW53", "WBGene00013135", "A0A2K5AU23", "WBGene00021324", "G5EF80", "WBGene00014051", "Q965N4", "WBGene00015267", "Q86NH1", "WBGene00006363", "Q19370", "WBGene00006406" ] }, "reaction_10571101": { "compartment": "compartment_876", "id": "reaction_10571101", "reactome": "R-CEL-9013145", "name": "RAC1 binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10571097", "species_10509457" ], "products": [ "species_10571099" ], "modifiers": [], "additional_components": [ "O44518", "WBGene00001579", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "O01583", "WBGene00006437", "G5EFU0", "WBGene00006443", "G5EDU3", "WBGene00004040", "A0A4V0ILM7", "WBGene00009793", "G5EDP9", "WBGene00000001", "Q94125", "WBGene00000090", "Q18879", "WBGene00000302", "Q94051", "WBGene00000301", "O17772", "WBGene00003980", "Q9BL72", "WBGene00021698", "Q17865", "WBGene00007486", "Q9NAN2", "WBGene00003921", "A5Z2X2", "WBGene00303007", "P55163", "WBGene00001580", "Q9XVK6", "WBGene00006958", "Q10929", "WBGene00015146", "species_29438", "Q03206", "ced-10", "species_29438", "Q03206", "ced-10", "O44518", "WBGene00001579", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "O01583", "WBGene00006437", "G5EFU0", "WBGene00006443", "G5EDU3", "WBGene00004040", "A0A4V0ILM7", "WBGene00009793", "G5EDP9", "WBGene00000001", "Q94125", "WBGene00000090", "Q18879", "WBGene00000302", "Q94051", "WBGene00000301", "O17772", "WBGene00003980", "Q9BL72", "WBGene00021698", "Q17865", "WBGene00007486", "Q9NAN2", "WBGene00003921", "A5Z2X2", "WBGene00303007", "P55163", "WBGene00001580", "Q9XVK6", "WBGene00006958", "Q10929", "WBGene00015146" ] }, "reaction_10571020": { "compartment": "compartment_876", "id": "reaction_10571020", "reactome": "R-CEL-9013143", "name": "RAC1 GEFs activate RAC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10541992" ], "products": [ "species_29420", "species_10509457" ], "modifiers": [ [ "species_10571017", "catalyst" ] ], "additional_components": [ "species_29420", "Q03206", "ced-10", "species_29438", "Q03206", "ced-10", "X5LX76", "WBGene00006450", "Q19572", "WBGene00001674", "O01847", "WBGene00015704", "Q45FX5", "WBGene00006887" ] }, "reaction_10571433": { "compartment": "compartment_876", "id": "reaction_10571433", "reactome": "R-CEL-9018794", "name": "RHOV binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10571429", "species_10571427" ], "products": [ "species_10571431" ], "modifiers": [], "additional_components": [ "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "G5EFU0", "WBGene00006443", "Q19739", "WBGene00009059", "species_29438", "Q19739", "WBGene00009059", "species_29438", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "G5EFU0", "WBGene00006443" ] }, "reaction_10571437": { "compartment": "compartment_876", "id": "reaction_10571437", "reactome": "R-CEL-9018798", "name": "RHOV binds GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10571435" ], "products": [ "species_29420", "species_10571427" ], "modifiers": [], "additional_components": [ "Q19739", "WBGene00009059", "species_29420", "Q19739", "WBGene00009059", "species_29438" ] }, "reaction_10571156": { "compartment": "compartment_876", "id": "reaction_10571156", "reactome": "R-CEL-9013161", "name": "CDC42 GAPs stimulate CDC42 GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10512279" ], "products": [ "species_10571134", "species_29372" ], "modifiers": [ [ "species_10571153", "catalyst" ] ], "additional_components": [ "Q05062", "WBGene00000390", "species_29438", "Q05062", "WBGene00000390", "species_29420", "Q9XW53", "WBGene00013135", "G5EF80", "WBGene00014051", "H2KZV4", "WBGene00017760", "Q23130", "WBGene00012203" ] }, "reaction_10571142": { "compartment": "compartment_876", "id": "reaction_10571142", "reactome": "R-CEL-9013158", "name": "CDC42 GDIs block activation of CDC42", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10571134", "species_10571138" ], "products": [ "species_10571140" ], "modifiers": [], "additional_components": [ "Q05062", "WBGene00000390", "species_29420", "Q20496", "WBGene00004356", "Q18879", "WBGene00000302", "Q94051", "WBGene00000301", "Q20496", "WBGene00004356", "Q18879", "WBGene00000302", "Q94051", "WBGene00000301", "Q05062", "WBGene00000390", "species_29420" ] }, "reaction_10573129": { "compartment": "compartment_876", "id": "reaction_10573129", "reactome": "R-CEL-9692800", "name": "CDC42 translocates to the endoplasmic reticulum membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10512279" ], "products": [ "species_10573127" ], "modifiers": [], "additional_components": [ "Q05062", "WBGene00000390", "species_29438", "Q05062", "WBGene00000390", "species_29438" ] }, "reaction_10571149": { "compartment": "compartment_876", "id": "reaction_10571149", "reactome": "R-CEL-9013159", "name": "CDC42 GEFs activate CDC42", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10571134", "species_29438" ], "products": [ "species_29420", "species_10512279" ], "modifiers": [ [ "species_10571146", "catalyst" ] ], "additional_components": [ "Q05062", "WBGene00000390", "species_29420", "Q05062", "WBGene00000390", "species_29438", "Q19572", "WBGene00001674", "X5LV34", "WBGene00001366", "G5EF62", "WBGene00009337", "Q965J0", "WBGene00019487", "H2KYI7", "WBGene00006496", "G5ECK4", "WBGene00044989" ] }, "reaction_10571217": { "compartment": "compartment_876", "id": "reaction_10571217", "reactome": "R-CEL-9013452", "name": "RHOD:GTP translocates to the endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10571194" ], "products": [ "species_10554702" ], "modifiers": [], "additional_components": [ "Q22038", "WBGene00004357", "species_29438", "Q22038", "WBGene00004357", "species_29438" ] }, "reaction_10573201": { "compartment": "compartment_876", "id": "reaction_10573201", "reactome": "R-CEL-9693243", "name": "RHOD translocates to the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10571194" ], "products": [ "species_10573199" ], "modifiers": [], "additional_components": [ "Q22038", "WBGene00004357", "species_29438", "Q22038", "WBGene00004357", "species_29438" ] }, "reaction_10573187": { "compartment": "compartment_876", "id": "reaction_10573187", "reactome": "R-CEL-9693207", "name": "RHOD translocates to the mitochondrial outer membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10571194" ], "products": [ "species_10573185" ], "modifiers": [], "additional_components": [ "Q22038", "WBGene00004357", "species_29438", "Q22038", "WBGene00004357", "species_29438" ] }, "reaction_10571202": { "compartment": "compartment_876", "id": "reaction_10571202", "reactome": "R-CEL-9013437", "name": "RHOD GAPs stimulate RHOD GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10571194" ], "products": [ "species_29372", "species_10571190" ], "modifiers": [ [ "species_10571199", "catalyst" ] ], "additional_components": [ "Q22038", "WBGene00004357", "species_29438", "Q22038", "WBGene00004357", "species_29420", "Q20498", "WBGene00009800", "O45611", "WBGene00010374", "H2KZV6", "WBGene00020209", "Q23130", "WBGene00012203" ] }, "reaction_10573195": { "compartment": "compartment_17906", "id": "reaction_10573195", "reactome": "R-CEL-9693214", "name": "RHOD binds effectors at the mitochondrial outer membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10573191", "species_10573185" ], "products": [ "species_10573193" ], "modifiers": [], "additional_components": [ "G5EFU0", "WBGene00006443", "Q22038", "WBGene00004357", "species_29438", "Q22038", "WBGene00004357", "species_29438", "G5EFU0", "WBGene00006443" ] }, "reaction_10571197": { "compartment": "compartment_876", "id": "reaction_10571197", "reactome": "R-CEL-9013435", "name": "RHOD auto-activates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10571190" ], "products": [ "species_29420", "species_10571194" ], "modifiers": [ [ "species_10571190", "catalyst" ] ], "additional_components": [ "Q22038", "WBGene00004357", "species_29420", "Q22038", "WBGene00004357", "species_29438", "Q22038", "WBGene00004357", "species_29420" ] }, "reaction_10573181": { "compartment": "compartment_70101", "id": "reaction_10573181", "reactome": "R-CEL-9693198", "name": "RHOD binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10571194", "species_10573177" ], "products": [ "species_10573179" ], "modifiers": [], "additional_components": [ "Q22038", "WBGene00004357", "species_29438", "Q23158", "WBGene00000228", "Q9XUT0", "WBGene00010664", "Q23130", "WBGene00012203", "Q18879", "WBGene00000302", "Q94051", "WBGene00000301", "Q23146", "WBGene00004271", "O02163", "WBGene00020376", "Q7K7J0", "WBGene00001575", "Q9XUB9", "WBGene00012128", "Q20952", "WBGene00000073", "Q9U9K0", "WBGene00000072", "Q7JP75", "WBGene00000872", "Q19479", "WBGene00008848", "Q9U2A6", "WBGene00012980", "B3WFV9", "WBGene00009920", "Q58QG8", "WBGene00019844", "O02495", "WBGene00004897", "H2KY90", "WBGene00015171", "A0A679L8R0", "WBGene00020443", "P34686", "WBGene00000293", "Q21443", "WBGene00003052", "Q23158", "WBGene00000228", "Q9XUT0", "WBGene00010664", "Q23130", "WBGene00012203", "Q18879", "WBGene00000302", "Q94051", "WBGene00000301", "Q23146", "WBGene00004271", "O02163", "WBGene00020376", "Q7K7J0", "WBGene00001575", "Q9XUB9", "WBGene00012128", "Q20952", "WBGene00000073", "Q9U9K0", "WBGene00000072", "Q7JP75", "WBGene00000872", "Q19479", "WBGene00008848", "Q9U2A6", "WBGene00012980", "B3WFV9", "WBGene00009920", "Q58QG8", "WBGene00019844", "O02495", "WBGene00004897", "H2KY90", "WBGene00015171", "A0A679L8R0", "WBGene00020443", "P34686", "WBGene00000293", "Q21443", "WBGene00003052", "Q22038", "WBGene00004357", "species_29438" ] }, "reaction_10571215": { "compartment": "compartment_876", "id": "reaction_10571215", "reactome": "R-CEL-9013438", "name": "RHOD binds effectors at the endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10554702", "species_10571211" ], "products": [ "species_10571213" ], "modifiers": [], "additional_components": [ "Q22038", "WBGene00004357", "species_29438", "Q7JP75", "WBGene00000872", "Q7JP75", "WBGene00000872", "Q22038", "WBGene00004357", "species_29438" ] }, "reaction_10571267": { "compartment": "compartment_70101", "id": "reaction_10571267", "reactome": "R-CEL-9014296", "name": "RAC2 GEFs activate RAC2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10571245" ], "products": [ "species_10509471", "species_29420" ], "modifiers": [ [ "species_10571264", "catalyst" ] ], "additional_components": [ "species_29420", "Q94124", "WBGene00004287", "Q9BL44", "WBGene00022177", "Q03206", "ced-10", "Q94124", "WBGene00004287", "Q9BL44", "WBGene00022177", "Q03206", "ced-10", "species_29438", "O01847", "WBGene00015704", "H2KYI7", "WBGene00006496", "Q45FX5", "WBGene00006887", "G5EEN3", "WBGene00000419" ] }, "reaction_10571251": { "compartment": "compartment_70101", "id": "reaction_10571251", "reactome": "R-CEL-9014293", "name": "RAC2 GDIs block activation of RAC2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10571245", "species_10570939" ], "products": [ "species_10571249" ], "modifiers": [], "additional_components": [ "species_29420", "Q94124", "WBGene00004287", "Q9BL44", "WBGene00022177", "Q03206", "ced-10", "WBGene00004356", "Q20496", "WBGene00004356", "Q94124", "WBGene00004287", "Q9BL44", "WBGene00022177", "Q03206", "ced-10", "species_29420" ] }, "reaction_10571269": { "compartment": "compartment_876", "id": "reaction_10571269", "reactome": "R-CEL-9014420", "name": "RAC2 translocates to the phagocytic vesicle membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509471" ], "products": [ "species_10554742" ], "modifiers": [], "additional_components": [ "Q94124", "WBGene00004287", "Q9BL44", "WBGene00022177", "Q03206", "ced-10", "species_29438", "Q94124", "WBGene00004287", "Q9BL44", "WBGene00022177", "Q03206", "ced-10", "species_29438" ] }, "reaction_10573381": { "compartment": "compartment_876", "id": "reaction_10573381", "reactome": "R-CEL-9714483", "name": "RAC2 translocates to the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509471" ], "products": [ "species_10573379" ], "modifiers": [], "additional_components": [ "Q94124", "WBGene00004287", "Q9BL44", "WBGene00022177", "Q03206", "ced-10", "species_29438", "Q03206", "ced-10", "Q94124", "WBGene00004287", "Q9BL44", "WBGene00022177", "species_29438" ] }, "reaction_10571257": { "compartment": "compartment_70101", "id": "reaction_10571257", "reactome": "R-CEL-9014294", "name": "RAC2 binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509471", "species_10571253" ], "products": [ "species_10571255" ], "modifiers": [], "additional_components": [ "Q94124", "WBGene00004287", "Q9BL44", "WBGene00022177", "Q03206", "ced-10", "species_29438", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "G5EFU0", "WBGene00006443", "G5EDU3", "WBGene00004040", "G5EDP9", "WBGene00000001", "Q94125", "WBGene00000090", "O17772", "WBGene00003980", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "G5EFU0", "WBGene00006443", "G5EDU3", "WBGene00004040", "G5EDP9", "WBGene00000001", "Q94125", "WBGene00000090", "O17772", "WBGene00003980", "Q94124", "WBGene00004287", "Q9BL44", "WBGene00022177", "Q03206", "ced-10", "species_29438" ] }, "reaction_10573369": { "compartment": "compartment_17906", "id": "reaction_10573369", "reactome": "R-CEL-9714477", "name": "RAC2 binds effectors at the mitochondrial outer membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10573348", "species_10573365" ], "products": [ "species_10573367" ], "modifiers": [], "additional_components": [ "Q9BL44", "WBGene00022177", "Q03206", "ced-10", "Q94124", "WBGene00004287", "species_29438", "Q9BL44", "WBGene00022177", "Q03206", "ced-10", "Q94124", "WBGene00004287", "species_29438" ] }, "reaction_10573371": { "compartment": "compartment_876", "id": "reaction_10573371", "reactome": "R-CEL-9714480", "name": "RAC2 translocates to the mitochondrial membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509471" ], "products": [ "species_10573348" ], "modifiers": [], "additional_components": [ "Q94124", "WBGene00004287", "Q9BL44", "WBGene00022177", "Q03206", "ced-10", "species_29438", "Q9BL44", "WBGene00022177", "Q03206", "ced-10", "Q94124", "WBGene00004287", "species_29438" ] }, "reaction_10571262": { "compartment": "compartment_70101", "id": "reaction_10571262", "reactome": "R-CEL-9014295", "name": "RAC2 GAPs stimulate RAC2 GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509471", "species_29356" ], "products": [ "species_29372", "species_10571245" ], "modifiers": [ [ "species_10571259", "catalyst" ] ], "additional_components": [ "Q94124", "WBGene00004287", "Q9BL44", "WBGene00022177", "Q03206", "ced-10", "species_29438", "species_29420", "Q94124", "WBGene00004287", "Q9BL44", "WBGene00022177", "Q03206", "ced-10", "O45611", "WBGene00010374", "H2KZV6", "WBGene00020209", "Q23130", "WBGene00012203" ] }, "reaction_10573170": { "compartment": "compartment_876", "id": "reaction_10573170", "reactome": "R-CEL-9693125", "name": "RHOF binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10573166", "species_10573139" ], "products": [ "species_10573168" ], "modifiers": [], "additional_components": [ "O17905", "WBGene00001490", "Q7JP75", "WBGene00000872", "Q19479", "WBGene00008848", "species_29438", "Q22038", "WBGene00004357", "species_29438", "Q22038", "WBGene00004357", "O17905", "WBGene00001490", "Q7JP75", "WBGene00000872", "Q19479", "WBGene00008848" ] }, "reaction_10573142": { "compartment": "compartment_876", "id": "reaction_10573142", "reactome": "R-CEL-9693111", "name": "RHOF auto-activates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10573137" ], "products": [ "species_29420", "species_10573139" ], "modifiers": [ [ "species_10573137", "catalyst" ] ], "additional_components": [ "species_29420", "Q22038", "WBGene00004357", "species_29438", "Q22038", "WBGene00004357", "species_29420", "Q22038", "WBGene00004357" ] }, "reaction_10573206": { "compartment": "compartment_876", "id": "reaction_10573206", "reactome": "R-CEL-9693282", "name": "RHOF GAPs stimulate RHOF GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10573139" ], "products": [ "species_29372", "species_10573137" ], "modifiers": [ [ "species_10573203", "catalyst" ] ], "additional_components": [ "species_29438", "Q22038", "WBGene00004357", "species_29420", "Q22038", "WBGene00004357", "Q23130", "WBGene00012203" ] }, "reaction_10553794": { "compartment": "compartment_70101", "id": "reaction_10553794", "reactome": "R-CEL-5626507", "name": "IQGAPs bind F-actin, which is inhibited by calmodulin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10523755", "species_10553786" ], "products": [ "species_10553790" ], "modifiers": [ [ "species_10553792", "inhibitor" ] ], "additional_components": [ "P0DM41", "WBGene00000063", "P0DM42", "WBGene00000065", "P10984", "WBGene00000064", "P10986", "WBGene00000066", "species_29358", "species_29438", "Q03206", "ced-10", "Q05062", "WBGene00000390", "O17772", "WBGene00003980", "species_29438", "Q03206", "ced-10", "Q05062", "WBGene00000390", "O17772", "WBGene00003980", "P0DM41", "WBGene00000063", "P0DM42", "WBGene00000065", "P10984", "WBGene00000064", "P10986", "WBGene00000066", "species_29358", "species_74016", "O16305", "WBGene00000552", "P04630", "WBGene00000285", "Q09665", "WBGene00006583", "A0A2C9C3L3", "WBGene00020378", "Q09980", "WBGene00017394", "G5EDZ8", "WBGene00000288", "Q11083", "WBGene00020378", "G5EEG0", "WBGene00000286", "Q18136", "WBGene00006861", "G5EF37", "WBGene00003934", "Q94288", "WBGene00000287", "O02159", "WBGene00020378", "species_29438", "Q03206", "ced-10", "Q05062", "WBGene00000390", "O17772", "WBGene00003980" ] }, "reaction_10553797": { "compartment": "compartment_876", "id": "reaction_10553797", "reactome": "R-CEL-5626549", "name": "IQGAPs bind CALM1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10553786", "species_10515137" ], "products": [ "species_10553792" ], "modifiers": [], "additional_components": [ "species_29438", "Q03206", "ced-10", "Q05062", "WBGene00000390", "O17772", "WBGene00003980", "species_74016", "O16305", "WBGene00000552", "P04630", "WBGene00000285", "Q09665", "WBGene00006583", "A0A2C9C3L3", "WBGene00020378", "Q09980", "WBGene00017394", "G5EDZ8", "WBGene00000288", "Q11083", "WBGene00020378", "G5EEG0", "WBGene00000286", "Q18136", "WBGene00006861", "G5EF37", "WBGene00003934", "Q94288", "WBGene00000287", "O02159", "WBGene00020378", "species_74016", "O16305", "WBGene00000552", "P04630", "WBGene00000285", "Q09665", "WBGene00006583", "A0A2C9C3L3", "WBGene00020378", "Q09980", "WBGene00017394", "G5EDZ8", "WBGene00000288", "Q11083", "WBGene00020378", "G5EEG0", "WBGene00000286", "Q18136", "WBGene00006861", "G5EF37", "WBGene00003934", "Q94288", "WBGene00000287", "O02159", "WBGene00020378", "species_29438", "Q03206", "ced-10", "Q05062", "WBGene00000390", "O17772", "WBGene00003980" ] }, "reaction_10553788": { "compartment": "compartment_70101", "id": "reaction_10553788", "reactome": "R-CEL-5626469", "name": "GTP-bound RAC1 and CDC42 bind IQGAPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10553784", "species_10520664" ], "products": [ "species_10553786" ], "modifiers": [], "additional_components": [ "O17772", "WBGene00003980", "species_29438", "Q03206", "ced-10", "Q05062", "WBGene00000390", "species_29438", "Q03206", "ced-10", "Q05062", "WBGene00000390", "O17772", "WBGene00003980" ] }, "reaction_10553925": { "compartment": "compartment_13949", "id": "reaction_10553925", "reactome": "R-CEL-5627071", "name": "RHOQ positively regulates trafficking of GOPC:CFTR to the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10553905" ], "products": [ "species_10553923" ], "modifiers": [ [ "species_10553905", "catalyst" ] ], "additional_components": [ "Q19625", "WBGene00003412", "Q95QV2", "WBGene00000477", "O18302", "WBGene00014101", "O62422", "WBGene00012532", "Q05062", "WBGene00000390", "species_29438", "O18302", "WBGene00014101", "Q19625", "WBGene00003412", "Q95QV2", "WBGene00000477", "O62422", "WBGene00012532", "Q05062", "WBGene00000390", "species_29438", "Q19625", "WBGene00003412", "Q95QV2", "WBGene00000477", "O18302", "WBGene00014101", "O62422", "WBGene00012532", "Q05062", "WBGene00000390", "species_29438" ] }, "reaction_10553944": { "compartment": "compartment_13949", "id": "reaction_10553944", "reactome": "R-CEL-5627275", "name": "GOPC promotes translocation of CFTR to lysosomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10553892" ], "products": [ "species_10553942" ], "modifiers": [ [ "species_10553892", "catalyst" ] ], "additional_components": [ "Q19625", "WBGene00003412", "Q95QV2", "WBGene00000477", "O18302", "WBGene00014101", "Q95QV2", "WBGene00000477", "Q19625", "WBGene00003412", "O18302", "WBGene00014101", "Q19625", "WBGene00003412", "Q95QV2", "WBGene00000477", "O18302", "WBGene00014101" ] }, "reaction_10554706": { "compartment": "compartment_70101", "id": "reaction_10554706", "reactome": "R-CEL-5666088", "name": "RHOD:GTP recruits DAIPH2-3 to endosomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10554702", "species_10554698" ], "products": [ "species_10554704" ], "modifiers": [], "additional_components": [ "Q22038", "WBGene00004357", "species_29438", "Q7JP75", "WBGene00000872", "Q7JP75", "WBGene00000872", "Q22038", "WBGene00004357", "species_29438" ] }, "reaction_10554612": { "compartment": "compartment_876", "id": "reaction_10554612", "reactome": "R-CEL-5665727", "name": "FMNL2 binds CDC42:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10512279", "species_10554608" ], "products": [ "species_10554610" ], "modifiers": [], "additional_components": [ "Q05062", "WBGene00000390", "species_29438", "P34489", "WBGene00010453", "Q9BL72", "WBGene00021698", "P34489", "WBGene00010453", "Q9BL72", "WBGene00021698", "Q05062", "WBGene00000390", "species_29438" ] }, "reaction_10548325": { "compartment": "compartment_70101", "id": "reaction_10548325", "reactome": "R-CEL-3858495", "name": "DAAM1 recruits GTP-bound RHOA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10548317", "species_10548321" ], "products": [ "species_10548323" ], "modifiers": [], "additional_components": [ "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "D6VPA1", "WBGene00018976", "species_114632", "Q22038", "WBGene00004357", "species_29438", "species_114632", "Q22038", "WBGene00004357", "species_29438", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "D6VPA1", "WBGene00018976" ] }, "reaction_10554694": { "compartment": "compartment_70101", "id": "reaction_10554694", "reactome": "R-CEL-5665989", "name": "DIAPH1 binds RHOA:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10554686", "species_10509488" ], "products": [ "species_10554688" ], "modifiers": [], "additional_components": [ "Q19479", "WBGene00008848", "Q7JP75", "WBGene00000872", "Q22038", "WBGene00004357", "species_29438", "Q22038", "WBGene00004357", "species_29438", "Q19479", "WBGene00008848", "Q7JP75", "WBGene00000872" ] }, "reaction_10554710": { "compartment": "compartment_70101", "id": "reaction_10554710", "reactome": "R-CEL-5666104", "name": "RHOD:GTP:DIAPH2-3 recruits SRC-1 to endosomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10513079", "species_10554704" ], "products": [ "species_10554708" ], "modifiers": [], "additional_components": [ "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q7JP75", "WBGene00000872", "Q22038", "WBGene00004357", "species_29438", "Q7JP75", "WBGene00000872", "Q22038", "WBGene00004357", "species_29438", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635" ] }, "reaction_10554633": { "compartment": "compartment_876", "id": "reaction_10554633", "reactome": "R-CEL-5665802", "name": "SRGAP2 binds RAC1:GTP:FMNL1:profilin:G-actin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10554629", "species_10554624" ], "products": [ "species_10554631" ], "modifiers": [], "additional_components": [ "WBGene00006406", "species_29438", "Q03206", "ced-10", "Q9BL72", "WBGene00021698", "P0DM41", "WBGene00000063", "P0DM42", "WBGene00000065", "P10984", "WBGene00000064", "P10986", "WBGene00000066", "species_29358", "species_29438", "Q03206", "ced-10", "Q9BL72", "WBGene00021698", "P0DM41", "WBGene00000063", "P0DM42", "WBGene00000065", "P10984", "WBGene00000064", "P10986", "WBGene00000066", "species_29358", "Q19370", "WBGene00006406" ] }, "reaction_10548319": { "compartment": "compartment_70101", "id": "reaction_10548319", "reactome": "R-CEL-3858489", "name": "ppDVL binds DAAM1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10548315", "species_10548290" ], "products": [ "species_10548317" ], "modifiers": [], "additional_components": [ "WBGene00018976", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "D6VPA1", "WBGene00018976" ] }, "reaction_10554723": { "compartment": "compartment_876", "id": "reaction_10554723", "reactome": "R-CEL-5666197", "name": "RHOA:GTP:RTKN binds LIN7B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10554719", "species_10519885" ], "products": [ "species_10554721" ], "modifiers": [], "additional_components": [ "Q22038", "WBGene00004357", "species_29438", "Q17777", "WBGene00007409", "WBGene00002996", "Q22038", "WBGene00004357", "species_29438", "Q17777", "WBGene00007409", "A5PEX5", "WBGene00002996" ] }, "reaction_10554732": { "compartment": "compartment_70101", "id": "reaction_10554732", "reactome": "R-CEL-5666216", "name": "RHOA:GTP:RTKN binds TAX1BP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10554719", "species_10554728" ], "products": [ "species_10554730" ], "modifiers": [], "additional_components": [ "Q22038", "WBGene00004357", "species_29438", "Q17777", "WBGene00007409", "WBGene00016678", "Q09506", "WBGene00016678", "Q22038", "WBGene00004357", "species_29438", "Q17777", "WBGene00007409" ] }, "reaction_10559350": { "compartment": "compartment_1222693", "id": "reaction_10559350", "reactome": "R-CEL-6798174", "name": "PIK3C3:PIK3R4 phosphorylates PI to PI3P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1524165" ], "products": [ "species_1629751", "species_29370" ], "modifiers": [ [ "species_10559347", "catalyst" ] ], "additional_components": [ "Q23669", "WBGene00014151", "Q9TXI7", "WBGene00006932" ] }, "reaction_10554803": { "compartment": "compartment_70101", "id": "reaction_10554803", "reactome": "R-CEL-5669158", "name": "NF2 binds PAK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10542001", "species_10520672" ], "products": [ "species_10554801" ], "modifiers": [], "additional_components": [ "WBGene00003593", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "H2KYX3", "WBGene00003593" ] }, "reaction_10542003": { "compartment": "compartment_70101", "id": "reaction_10542003", "reactome": "R-CEL-2029456", "name": "RAC1 and CDC42 activate PAK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10520664", "species_10520672" ], "products": [ "species_10520670", "species_10541994" ], "modifiers": [ [ "species_10542001", "inhibitor" ] ], "additional_components": [ "species_29438", "Q03206", "ced-10", "Q05062", "WBGene00000390", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "species_29438", "Q03206", "ced-10", "Q05062", "WBGene00000390", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "WBGene00003593" ] }, "reaction_10553954": { "compartment": "compartment_70101", "id": "reaction_10553954", "reactome": "R-CEL-5627775", "name": "Autophosphorylation of PAK1,2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10553951", "species_113592" ], "products": [ "species_29370", "species_10520664", "species_10521284" ], "modifiers": [ [ "species_10553951", "catalyst" ] ], "additional_components": [ "species_29438", "Q03206", "ced-10", "Q05062", "WBGene00000390", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "species_29438", "Q03206", "ced-10", "Q05062", "WBGene00000390", "Q17850", "WBGene00003911", "G5EGQ3", "WBGene00003144", "species_29438", "Q03206", "ced-10", "Q05062", "WBGene00000390", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911" ] }, "reaction_10554822": { "compartment": "compartment_70101", "id": "reaction_10554822", "reactome": "R-CEL-5669250", "name": "PAK1 phosphorylates FLNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10554807" ], "products": [ "species_29370", "species_10521268", "species_10554819" ], "modifiers": [ [ "species_10554807", "catalyst" ] ], "additional_components": [ "Q17850", "WBGene00003911", "G5EGQ3", "WBGene00003144", "D0VWL6", "WBGene00016006", "U4PBJ9", "WBGene00022048", "Q17850", "WBGene00003911", "G5EGQ3", "WBGene00003144", "D0VWL6", "WBGene00016006", "U4PBJ9", "WBGene00022048", "Q17850", "WBGene00003911", "G5EGQ3", "WBGene00003144", "D0VWL6", "WBGene00016006", "U4PBJ9", "WBGene00022048" ] }, "reaction_10554809": { "compartment": "compartment_70101", "id": "reaction_10554809", "reactome": "R-CEL-5669240", "name": "FLNA binds PAK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10521268", "species_10554805" ], "products": [ "species_10554807" ], "modifiers": [], "additional_components": [ "Q17850", "WBGene00003911", "G5EGQ3", "WBGene00003144", "D0VWL6", "WBGene00016006", "U4PBJ9", "WBGene00022048", "Q17850", "WBGene00003911", "G5EGQ3", "WBGene00003144", "D0VWL6", "WBGene00016006", "U4PBJ9", "WBGene00022048" ] }, "reaction_10570440": { "compartment": "compartment_70101", "id": "reaction_10570440", "reactome": "R-CEL-8981926", "name": "RAC1 and CDC42 activate PAK3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10520684", "species_10520664" ], "products": [ "species_10553949", "species_10520682" ], "modifiers": [], "additional_components": [ "Q17850", "WBGene00003911", "species_29438", "Q03206", "ced-10", "Q05062", "WBGene00000390", "species_29438", "Q03206", "ced-10", "Q05062", "WBGene00000390", "Q17850", "WBGene00003911", "WBGene00003911" ] }, "reaction_10570442": { "compartment": "compartment_70101", "id": "reaction_10570442", "reactome": "R-CEL-8981931", "name": "RAC1 and CDC42 activate PAK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10520680", "species_10520664" ], "products": [ "species_10553947", "species_10520678" ], "modifiers": [], "additional_components": [ "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "species_29438", "Q03206", "ced-10", "Q05062", "WBGene00000390", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "species_29438", "Q03206", "ced-10", "Q05062", "WBGene00000390", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911" ] }, "reaction_10554783": { "compartment": "compartment_70101", "id": "reaction_10554783", "reactome": "R-CEL-5668932", "name": "PAK2 phosphorylates myosin regulatory light chain (MRLC)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10554760" ], "products": [ "species_10554780", "species_29370" ], "modifiers": [ [ "species_10521278", "catalyst" ] ], "additional_components": [ "Q20641", "WBGene00003776", "G5EBY3", "WBGene00003777", "P19625", "WBGene00003369", "P19626", "WBGene00003370", "Q09510", "WBGene00003372", "Q20238", "WBGene00009585", "Q21201", "WBGene00010554", "Q69Z12", "WBGene00023451", "Q9XVI9", "WBGene00011734", "P53014", "WBGene00003371", "Q20641", "WBGene00003776", "G5EBY3", "WBGene00003777", "Q20238", "WBGene00009585", "Q21201", "WBGene00010554", "Q69Z12", "WBGene00023451", "Q9XVI9", "WBGene00011734", "P53014", "WBGene00003371", "P19625", "WBGene00003369", "P19626", "WBGene00003370", "Q09510", "WBGene00003372", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911" ] }, "reaction_10554799": { "compartment": "compartment_70101", "id": "reaction_10554799", "reactome": "R-CEL-5668947", "name": "PAK1 phosphorylates myosin phosphatase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10554791" ], "products": [ "species_10554796", "species_29370" ], "modifiers": [ [ "species_10521268", "catalyst" ] ], "additional_components": [ "Q27497", "WBGene00001747", "G5ECD7", "WBGene00003196", "Q27497", "WBGene00001747", "G5ECD7", "WBGene00003196", "Q17850", "WBGene00003911", "G5EGQ3", "WBGene00003144" ] }, "reaction_10554832": { "compartment": "compartment_70101", "id": "reaction_10554832", "reactome": "R-CEL-5671737", "name": "p-T774-PKN1 binds CDC25C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10553254", "species_10509856" ], "products": [ "species_10554830" ], "modifiers": [], "additional_components": [ "WBGene00009793", "WBGene00000389", "Q21762", "WBGene00000389", "A0A4V0ILM7", "WBGene00009793" ] }, "reaction_10507073": { "compartment": "compartment_70101", "id": "reaction_10507073", "reactome": "R-CEL-75016", "name": "Association of p-S216-CDC25C with 14-3-3 proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10507069", "species_10507019" ], "products": [ "species_10507071" ], "modifiers": [], "additional_components": [ "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "WBGene00000389", "Q21762", "WBGene00000389", "P41932", "WBGene00003920", "Q20655", "WBGene00001502" ] }, "reaction_10554835": { "compartment": "compartment_70101", "id": "reaction_10554835", "reactome": "R-CEL-5671749", "name": "p-T774-PKN1 phosphorylates CDC25C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10554830", "species_113592" ], "products": [ "species_10507019", "species_29370", "species_10553254" ], "modifiers": [ [ "species_10554830", "catalyst" ] ], "additional_components": [ "Q21762", "WBGene00000389", "A0A4V0ILM7", "WBGene00009793", "WBGene00000389", "WBGene00009793", "Q21762", "WBGene00000389", "A0A4V0ILM7", "WBGene00009793" ] }, "reaction_10554850": { "compartment": "compartment_70101", "id": "reaction_10554850", "reactome": "R-CEL-5671772", "name": "p-T38-PPP1R14A binds MLCP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10554843", "species_10554791" ], "products": [ "species_10554848" ], "modifiers": [], "additional_components": [ "WBGene00010109", "Q27497", "WBGene00001747", "G5ECD7", "WBGene00003196", "Q27497", "WBGene00001747", "G5ECD7", "WBGene00003196", "Q7YX00", "WBGene00010109" ] }, "reaction_10553239": { "compartment": "compartment_876", "id": "reaction_10553239", "reactome": "R-CEL-5623622", "name": "RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10553227", "species_10553235" ], "products": [ "species_10553237" ], "modifiers": [], "additional_components": [ "WBGene00009793", "Q22038", "WBGene00004357", "species_29438", "Q22038", "WBGene00004357", "species_29438", "A0A4V0ILM7", "WBGene00009793" ] }, "reaction_10553243": { "compartment": "compartment_876", "id": "reaction_10553243", "reactome": "R-CEL-5623632", "name": "RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10553237", "species_10508530" ], "products": [ "species_10553241" ], "modifiers": [], "additional_components": [ "Q22038", "WBGene00004357", "species_29438", "A0A4V0ILM7", "WBGene00009793", "Q9UA62", "WBGene00021022", "species_179838", "Q9UA62", "WBGene00021022", "species_179838", "Q22038", "WBGene00004357", "species_29438", "A0A4V0ILM7", "WBGene00009793" ] }, "reaction_10553263": { "compartment": "compartment_70101", "id": "reaction_10553263", "reactome": "R-CEL-5623667", "name": "PDPK1 phosphorylates PKN1,2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10553241" ], "products": [ "species_29370", "species_10553254", "species_10553235", "species_10508530" ], "modifiers": [ [ "species_10553241", "catalyst" ] ], "additional_components": [ "Q9UA62", "WBGene00021022", "species_179838", "Q22038", "WBGene00004357", "species_29438", "A0A4V0ILM7", "WBGene00009793", "WBGene00009793", "Q22038", "WBGene00004357", "species_29438", "Q9UA62", "WBGene00021022", "species_179838", "Q9UA62", "WBGene00021022", "species_179838", "Q22038", "WBGene00004357", "species_29438", "A0A4V0ILM7", "WBGene00009793" ] }, "reaction_10553760": { "compartment": "compartment_7660", "id": "reaction_10553760", "reactome": "R-CEL-5625797", "name": "KDM4C demethylates Me3K-10-H3 associated with KLK2 and KLK3 promoters", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113671", "species_113685", "species_10553745" ], "products": [ "species_10553757", "species_29478", "species_10549605", "species_159942", "species_159939" ], "modifiers": [ [ "species_10553745", "catalyst" ] ], "additional_components": [ "Q9U297", "WBGene00012982", "A0A4V0ILM7", "WBGene00009793", "species_469662", "CHEBI:29117", "species_193057", "species_193079", "P62784", "WBGene00001875", "K7ZUH9", "WBGene00001914", "Q10453", "WBGene00001945", "A0A4V0ILM7", "WBGene00009793", "species_469662", "CHEBI:29117", "species_193057", "species_193079", "P62784", "WBGene00001875", "Q10453", "WBGene00001945", "K7ZUH9", "WBGene00001914", "WBGene00012982", "Q9U297", "WBGene00012982", "A0A4V0ILM7", "WBGene00009793", "species_469662", "CHEBI:29117", "species_193057", "species_193079", "P62784", "WBGene00001875", "K7ZUH9", "WBGene00001914", "Q10453", "WBGene00001945" ] }, "reaction_10553747": { "compartment": "compartment_7660", "id": "reaction_10553747", "reactome": "R-CEL-5625796", "name": "Demethylase KDM4C binds KLK2 and KLK3 promoters", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10553740", "species_10549605" ], "products": [ "species_10553745" ], "modifiers": [], "additional_components": [ "A0A4V0ILM7", "WBGene00009793", "species_469662", "CHEBI:29117", "species_193057", "species_193079", "P62784", "WBGene00001875", "K7ZUH9", "WBGene00001914", "Q10453", "WBGene00001945", "WBGene00012982", "Q9U297", "WBGene00012982", "A0A4V0ILM7", "WBGene00009793", "species_469662", "CHEBI:29117", "species_193057", "species_193079", "P62784", "WBGene00001875", "K7ZUH9", "WBGene00001914", "Q10453", "WBGene00001945" ] }, "reaction_10553743": { "compartment": "compartment_7660", "id": "reaction_10553743", "reactome": "R-CEL-5625784", "name": "PKN1 phosphorylates histone 3 of nucleosomes associate with KLK2 and KLK3 promoters", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10553726", "species_29358" ], "products": [ "species_113582", "species_10553740" ], "modifiers": [ [ "species_10553726", "catalyst" ] ], "additional_components": [ "A0A4V0ILM7", "WBGene00009793", "species_469662", "CHEBI:29117", "species_193057", "species_193079", "P62784", "WBGene00001875", "Q10453", "WBGene00001945", "K7ZUH9", "WBGene00001914", "A0A4V0ILM7", "WBGene00009793", "species_469662", "CHEBI:29117", "species_193057", "species_193079", "P62784", "WBGene00001875", "K7ZUH9", "WBGene00001914", "Q10453", "WBGene00001945", "A0A4V0ILM7", "WBGene00009793", "species_469662", "CHEBI:29117", "species_193057", "species_193079", "P62784", "WBGene00001875", "Q10453", "WBGene00001945", "K7ZUH9", "WBGene00001914" ] }, "reaction_10554846": { "compartment": "compartment_70101", "id": "reaction_10554846", "reactome": "R-CEL-5671763", "name": "p-T774-PKN1 phosphorylates PPP1R14A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10554840" ], "products": [ "species_10554843", "species_29370" ], "modifiers": [ [ "species_10553254", "catalyst" ] ], "additional_components": [ "WBGene00010109", "WBGene00010109", "WBGene00009793" ] }, "reaction_10542752": { "compartment": "compartment_876", "id": "reaction_10542752", "reactome": "R-CEL-2130194", "name": "ABL phosphorylates WAVEs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10542749", "species_113592" ], "products": [ "species_29370", "species_10542068" ], "modifiers": [ [ "species_10519289", "catalyst" ] ], "additional_components": [ "species_29438", "Q03206", "ced-10", "A5Z2X2", "WBGene00303007", "O44518", "WBGene00001579", "P55163", "WBGene00001580", "Q9XVK6", "WBGene00006958", "Q10929", "WBGene00015146", "species_179838", "species_29438", "Q03206", "ced-10", "A5Z2X2", "WBGene00303007", "O44518", "WBGene00001579", "P55163", "WBGene00001580", "Q10929", "WBGene00015146", "Q9XVK6", "WBGene00006958", "species_179838", "WBGene00000018" ] }, "reaction_10542112": { "compartment": "compartment_70101", "id": "reaction_10542112", "reactome": "R-CEL-2029473", "name": "Branching and elongation of mother and daughter filaments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10542110", "species_10515381" ], "products": [ "species_10537825" ], "modifiers": [], "additional_components": [ "P0DM41", "WBGene00000063", "P0DM42", "WBGene00000065", "P10984", "WBGene00000064", "P10986", "WBGene00000066", "species_29358", "species_113582", "P58798", "WBGene00000204", "A0A3P6PCS5", "WBGene00000201", "Q9N4I0", "WBGene00000199", "Q8WTM6", "WBGene00021170", "P53489", "WBGene00000200", "Q9XWV3", "WBGene00000203", "O61861", "WBGene00000205", "P91167", "WBGene00016729", "P0DM41", "WBGene00000063", "P0DM42", "WBGene00000065", "P10984", "WBGene00000064", "P10986", "WBGene00000066", "species_29358", "P0DM41", "WBGene00000063", "P0DM42", "WBGene00000065", "P10984", "WBGene00000064", "P10986", "WBGene00000066", "species_29358", "P58798", "WBGene00000204", "A0A3P6PCS5", "WBGene00000201", "Q9N4I0", "WBGene00000199", "Q8WTM6", "WBGene00021170", "P53489", "WBGene00000200", "Q9XWV3", "WBGene00000203", "O61861", "WBGene00000205", "P91167", "WBGene00016729" ] }, "reaction_10542085": { "compartment": "compartment_70101", "id": "reaction_10542085", "reactome": "R-CEL-2029469", "name": "p-ERK phosphorylates WAVEs and ABI", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10542068" ], "products": [ "species_29370", "species_10542054" ], "modifiers": [ [ "species_10542082", "catalyst" ] ], "additional_components": [ "species_29438", "Q03206", "ced-10", "A5Z2X2", "WBGene00303007", "O44518", "WBGene00001579", "P55163", "WBGene00001580", "Q10929", "WBGene00015146", "Q9XVK6", "WBGene00006958", "species_179838", "species_29438", "Q03206", "ced-10", "A5Z2X2", "WBGene00303007", "O44518", "WBGene00001579", "P55163", "WBGene00001580", "Q9XVK6", "WBGene00006958", "Q10929", "WBGene00015146", "species_179838", "P39745", "WBGene00003401" ] }, "reaction_10543483": { "compartment": "compartment_70101", "id": "reaction_10543483", "reactome": "R-CEL-2197690", "name": "Detachment of WASP/WAVE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10542074" ], "products": [ "species_10542110", "species_10542070" ], "modifiers": [], "additional_components": [ "P0DM41", "WBGene00000063", "P0DM42", "WBGene00000065", "P10984", "WBGene00000064", "P10986", "WBGene00000066", "species_29358", "species_29438", "Q03206", "ced-10", "A5Z2X2", "WBGene00303007", "O44518", "WBGene00001579", "P55163", "WBGene00001580", "Q10929", "WBGene00015146", "Q9XVK6", "WBGene00006958", "species_179838", "P58798", "WBGene00000204", "A0A3P6PCS5", "WBGene00000201", "Q9N4I0", "WBGene00000199", "Q8WTM6", "WBGene00021170", "P53489", "WBGene00000200", "Q9XWV3", "WBGene00000203", "O61861", "WBGene00000205", "P91167", "WBGene00016729", "P0DM41", "WBGene00000063", "P0DM42", "WBGene00000065", "P10984", "WBGene00000064", "P10986", "WBGene00000066", "species_29358", "species_113582", "P58798", "WBGene00000204", "A0A3P6PCS5", "WBGene00000201", "Q9N4I0", "WBGene00000199", "Q8WTM6", "WBGene00021170", "P53489", "WBGene00000200", "Q9XWV3", "WBGene00000203", "O61861", "WBGene00000205", "P91167", "WBGene00016729", "species_29438", "Q03206", "ced-10", "A5Z2X2", "WBGene00303007", "O44518", "WBGene00001579", "P55163", "WBGene00001580", "Q10929", "WBGene00015146", "Q9XVK6", "WBGene00006958", "species_179838" ] }, "reaction_10542076": { "compartment": "compartment_70101", "id": "reaction_10542076", "reactome": "R-CEL-2029466", "name": "(WASPs, WAVE):G-actin:ARP2/3 binds F-actin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10523755", "species_10542072" ], "products": [ "species_10542074" ], "modifiers": [], "additional_components": [ "P0DM41", "WBGene00000063", "P0DM42", "WBGene00000065", "P10984", "WBGene00000064", "P10986", "WBGene00000066", "species_29358", "P0DM41", "WBGene00000063", "P0DM42", "WBGene00000065", "P10984", "WBGene00000064", "P10986", "WBGene00000066", "species_29358", "species_29438", "Q03206", "ced-10", "A5Z2X2", "WBGene00303007", "O44518", "WBGene00001579", "P55163", "WBGene00001580", "Q10929", "WBGene00015146", "Q9XVK6", "WBGene00006958", "species_179838", "P58798", "WBGene00000204", "A0A3P6PCS5", "WBGene00000201", "Q9N4I0", "WBGene00000199", "Q8WTM6", "WBGene00021170", "P53489", "WBGene00000200", "Q9XWV3", "WBGene00000203", "O61861", "WBGene00000205", "P91167", "WBGene00016729", "P0DM41", "WBGene00000063", "P0DM42", "WBGene00000065", "P10984", "WBGene00000064", "P10986", "WBGene00000066", "species_29358", "species_29438", "Q03206", "ced-10", "A5Z2X2", "WBGene00303007", "O44518", "WBGene00001579", "P55163", "WBGene00001580", "Q10929", "WBGene00015146", "Q9XVK6", "WBGene00006958", "species_179838", "P58798", "WBGene00000204", "A0A3P6PCS5", "WBGene00000201", "Q9N4I0", "WBGene00000199", "Q8WTM6", "WBGene00021170", "P53489", "WBGene00000200", "Q9XWV3", "WBGene00000203", "O61861", "WBGene00000205", "P91167", "WBGene00016729" ] }, "reaction_10571243": { "compartment": "compartment_984", "id": "reaction_10571243", "reactome": "R-CEL-9014052", "name": "TXLNA (IL14) binds syntaxin3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10525375", "species_10571239" ], "products": [ "species_10571241" ], "modifiers": [], "additional_components": [ "WBGene00011917", "Q20024", "WBGene00006371", "Q20574", "WBGene00006372", "O16000", "WBGene00006798", "Q20024", "WBGene00006371", "Q20574", "WBGene00006372", "O16000", "WBGene00006798", "Q22666", "WBGene00011917" ] }, "reaction_10525389": { "compartment": "compartment_984", "id": "reaction_10525389", "reactome": "R-CEL-449117", "name": "TXLNA (IL14) binds syntaxin1A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10525375", "species_10516749" ], "products": [ "species_10525377" ], "modifiers": [ [ "species_10525387", "inhibitor" ] ], "additional_components": [ "WBGene00011917", "WBGene00006798", "O16000", "WBGene00006798", "Q22666", "WBGene00011917", "G5EEN8", "WBGene00006454", "A5PEW5", "WBGene00004364", "O44412", "WBGene00020298", "P34815", "WBGene00006757", "O16000", "WBGene00006798" ] }, "reaction_10528533": { "compartment": "compartment_70101", "id": "reaction_10528533", "reactome": "R-CEL-912734", "name": "CBL:CRKL binds RAPGEF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10528524", "species_10528529" ], "products": [ "species_10528531" ], "modifiers": [], "additional_components": [ "Q19019", "WBGene00004829", "Q9NHC3", "WBGene00000416", "Q95XA9", "WBGene00021238", "WBGene00021320", "H2KZX7", "WBGene00021320", "Q19019", "WBGene00004829", "Q9NHC3", "WBGene00000416", "Q95XA9", "WBGene00021238" ] }, "reaction_10528518": { "compartment": "compartment_70101", "id": "reaction_10528518", "reactome": "R-CEL-912627", "name": "CBL ubiquitinates PI3K", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10528462", "species_10528505" ], "products": [ "species_10528516" ], "modifiers": [], "additional_components": [ "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "P29355", "WBGene00004774", "G5EDP9", "WBGene00000001", "Q94125", "WBGene00000090", "Q19019", "WBGene00004829", "P37165", "WBGene00006725", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "Q94125", "WBGene00000090", "G5EDP9", "WBGene00000001", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "P29355", "WBGene00004774", "Q19019", "WBGene00004829" ] }, "reaction_10528535": { "compartment": "compartment_70101", "id": "reaction_10528535", "reactome": "R-CEL-912790", "name": "CBL binds CRK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10520269", "species_10528460" ], "products": [ "species_10528524" ], "modifiers": [], "additional_components": [ "Q9NHC3", "WBGene00000416", "Q95XA9", "WBGene00021238", "WBGene00004829", "Q19019", "WBGene00004829", "Q9NHC3", "WBGene00000416", "Q95XA9", "WBGene00021238" ] }, "reaction_10528266": { "compartment": "compartment_70101", "id": "reaction_10528266", "reactome": "R-CEL-879917", "name": "CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10506892", "species_10512267", "species_10506871", "species_10528262" ], "products": [ "species_10528264" ], "modifiers": [], "additional_components": [ "G5EDP9", "WBGene00000001", "Q94125", "WBGene00000090", "WBGene00004829", "WBGene00004774", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "P29355", "WBGene00004774", "Q19019", "WBGene00004829", "G5EDP9", "WBGene00000001", "Q94125", "WBGene00000090" ] }, "reaction_10528522": { "compartment": "compartment_70101", "id": "reaction_10528522", "reactome": "R-CEL-912727", "name": "CBL binds VAV", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10528460", "species_10516075" ], "products": [ "species_10528520" ], "modifiers": [], "additional_components": [ "WBGene00004829", "WBGene00006887", "Q45FX5", "WBGene00006887", "Q19019", "WBGene00004829" ] }, "reaction_10531907": { "compartment": "compartment_70101", "id": "reaction_10531907", "reactome": "R-CEL-1112587", "name": "STAT1 and STAT3 dimers translocate to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10531891" ], "products": [ "species_10531905" ], "modifiers": [], "additional_components": [ "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111" ] }, "reaction_10531893": { "compartment": "compartment_70101", "id": "reaction_10531893", "reactome": "R-CEL-1112538", "name": "Phosphorylated STAT1, STAT3 form dimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10531885" ], "products": [ "species_10531891" ], "modifiers": [], "additional_components": [ "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111" ] }, "reaction_10573100": { "compartment": "compartment_984", "id": "reaction_10573100", "reactome": "R-CEL-9681294", "name": "IL6R binds IL6R inhibitors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10573096", "species_9715042" ], "products": [ "species_10573098" ], "modifiers": [], "additional_components": [ "WBGene00002915", "Q9UB28", "WBGene00002915" ] }, "reaction_10558097": { "compartment": "compartment_70101", "id": "reaction_10558097", "reactome": "R-CEL-6784765", "name": "p-Y705-STAT3 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10531883" ], "products": [ "species_10531887" ], "modifiers": [], "additional_components": [ "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111" ] }, "reaction_10558095": { "compartment": "compartment_70101", "id": "reaction_10558095", "reactome": "R-CEL-6784763", "name": "p-Y705-STAT3 dimer translocates from cytosol to nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10531887" ], "products": [ "species_10531903" ], "modifiers": [], "additional_components": [ "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111" ] }, "reaction_10570566": { "compartment": "compartment_70101", "id": "reaction_10570566", "reactome": "R-CEL-8985943", "name": "p-Y701-STAT1 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10570562" ], "products": [ "species_10570564" ], "modifiers": [], "additional_components": [ "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251" ] }, "reaction_10570584": { "compartment": "compartment_70101", "id": "reaction_10570584", "reactome": "R-CEL-8985981", "name": "p-Y701-STAT1:p-Y705-STAT3 translocates from the cytosol to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10570572" ], "products": [ "species_10570582" ], "modifiers": [], "additional_components": [ "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251" ] }, "reaction_10570570": { "compartment": "compartment_70101", "id": "reaction_10570570", "reactome": "R-CEL-8985950", "name": "p-Y649-STAT5A, p-STAT5B dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10570515" ], "products": [ "species_10570568" ], "modifiers": [], "additional_components": [] }, "reaction_10570574": { "compartment": "compartment_70101", "id": "reaction_10570574", "reactome": "R-CEL-8985966", "name": "p-Y701-STAT1 binds p-Y705-STAT3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10570521", "species_10570562" ], "products": [ "species_10570572" ], "modifiers": [], "additional_components": [ "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251" ] }, "reaction_10570611": { "compartment": "compartment_70101", "id": "reaction_10570611", "reactome": "R-CEL-8987007", "name": "p-STAT1 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10569000" ], "products": [ "species_10570609" ], "modifiers": [], "additional_components": [ "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111" ] }, "reaction_10570643": { "compartment": "compartment_70101", "id": "reaction_10570643", "reactome": "R-CEL-8987218", "name": "p-STAT1 dimer translocates from the cytosol to the nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10570609" ], "products": [ "species_10570641" ], "modifiers": [], "additional_components": [ "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111" ] }, "reaction_10570629": { "compartment": "compartment_70101", "id": "reaction_10570629", "reactome": "R-CEL-8987052", "name": "p-STAT3 dimer translocates from cytosol to nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10570619" ], "products": [ "species_10570627" ], "modifiers": [], "additional_components": [ "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111" ] }, "reaction_10570633": { "compartment": "compartment_70101", "id": "reaction_10570633", "reactome": "R-CEL-8987214", "name": "p-STAT3 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10570617" ], "products": [ "species_10570619" ], "modifiers": [], "additional_components": [ "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111" ] }, "reaction_10558321": { "compartment": "compartment_70101", "id": "reaction_10558321", "reactome": "R-CEL-6788622", "name": "p-Y-STATs dimerize", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10558317" ], "products": [ "species_10558319" ], "modifiers": [], "additional_components": [ "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111" ] }, "reaction_10558499": { "compartment": "compartment_17957", "id": "reaction_10558499", "reactome": "R-CEL-6790038", "name": "Expression of HSP90B1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [], "products": [ "species_10558497" ], "modifiers": [ [ "species_10531903", "catalyst" ] ], "additional_components": [ "WBGene00011480", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111" ] }, "reaction_10558325": { "compartment": "compartment_70101", "id": "reaction_10558325", "reactome": "R-CEL-6788623", "name": "p-Y-STATs translocate to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10558319" ], "products": [ "species_10558323" ], "modifiers": [], "additional_components": [ "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111" ] }, "reaction_10558148": { "compartment": "compartment_70101", "id": "reaction_10558148", "reactome": "R-CEL-6786097", "name": "p-Y705-STAT3, p-Y641-STAT6 dimerise", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10558142" ], "products": [ "species_10558146" ], "modifiers": [], "additional_components": [ "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111" ] }, "reaction_10558206": { "compartment": "compartment_70101", "id": "reaction_10558206", "reactome": "R-CEL-6786293", "name": "p-Y705-STAT3 dimer, p-Y641-STAT6 dimer translocate to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10558146" ], "products": [ "species_10558204" ], "modifiers": [], "additional_components": [ "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111" ] }, "reaction_10570774": { "compartment": "compartment_70101", "id": "reaction_10570774", "reactome": "R-CEL-9009072", "name": "STAT3 phosphorylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10519913" ], "products": [ "species_29370", "species_10570521" ], "modifiers": [], "additional_components": [ "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111" ] }, "reaction_10526186": { "compartment": "compartment_70101", "id": "reaction_10526186", "reactome": "R-CEL-451418", "name": "Pellino ubiquitinates IRAK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10526177" ], "products": [ "species_10526183" ], "modifiers": [ [ "species_10526177", "catalyst" ] ], "additional_components": [ "Q22967", "WBGene00017766", "Q95XX0", "WBGene00006708", "O45495", "WBGene00006730", "P37165", "WBGene00006725", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "Q22967", "WBGene00017766", "Q95XX0", "WBGene00006708", "O45495", "WBGene00006730", "Q22967", "WBGene00017766", "Q95XX0", "WBGene00006708", "O45495", "WBGene00006730", "P37165", "WBGene00006725", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727" ] }, "reaction_10525239": { "compartment": "compartment_70101", "id": "reaction_10525239", "reactome": "R-CEL-448673", "name": "Formation of caspase-1 p10/p20 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10525229", "species_10525235" ], "products": [ "species_10525237" ], "modifiers": [], "additional_components": [ "G5EBM1", "WBGene00000819", "P42573", "WBGene00000417", "P42573", "WBGene00000417", "G5EBM1", "WBGene00000819", "P42573", "WBGene00000417", "G5EBM1", "WBGene00000819" ] }, "reaction_10525261": { "compartment": "compartment_70101", "id": "reaction_10525261", "reactome": "R-CEL-448702", "name": "Caspase-1 active tetramer formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10525237" ], "products": [ "species_10525259" ], "modifiers": [], "additional_components": [ "P42573", "WBGene00000417", "G5EBM1", "WBGene00000819", "P42573", "WBGene00000417", "G5EBM1", "WBGene00000819" ] }, "reaction_10570684": { "compartment": "compartment_984", "id": "reaction_10570684", "reactome": "R-CEL-9008043", "name": "MAPK8 phosphorylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10510931" ], "products": [ "species_29370", "species_10510951" ], "modifiers": [], "additional_components": [ "WBGene00002178", "WBGene00002178" ] }, "reaction_10533055": { "compartment": "compartment_984", "id": "reaction_10533055", "reactome": "R-CEL-1362465", "name": "GHBP binds GHR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10530700", "species_10533051" ], "products": [ "species_10533053" ], "modifiers": [], "additional_components": [ "WBGene00002915", "WBGene00002915", "Q9UB28", "WBGene00002915" ] }, "reaction_10543479": { "compartment": "compartment_70101", "id": "reaction_10543479", "reactome": "R-CEL-2187401", "name": "MTMR4 dephosphorylates SMAD2/3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10543476" ], "products": [ "species_29372", "species_10543474", "species_10511457" ], "modifiers": [ [ "species_10543476", "catalyst" ] ], "additional_components": [ "Q22712", "WBGene00003476", "Q21733", "WBGene00000904", "WBGene00003476", "WBGene00000904", "Q22712", "WBGene00003476", "Q21733", "WBGene00000904" ] }, "reaction_10543464": { "compartment": "compartment_70101", "id": "reaction_10543464", "reactome": "R-CEL-2187368", "name": "STUB1 (CHIP) ubiquitinates SMAD3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502375", "species_10543459" ], "products": [ "species_10543461", "species_10530864" ], "modifiers": [ [ "species_10543459", "catalyst" ] ], "additional_components": [ "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "G5ECY6", "WBGene00000500", "Q21733", "WBGene00000904", "Q21733", "WBGene00000904", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "WBGene00000500", "G5ECY6", "WBGene00000500", "Q21733", "WBGene00000904" ] }, "reaction_10543481": { "compartment": "compartment_70101", "id": "reaction_10543481", "reactome": "R-CEL-2187405", "name": "MTMR4 binds phosphorylated SMAD2/3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10511411", "species_10543474" ], "products": [ "species_10543476" ], "modifiers": [], "additional_components": [ "WBGene00000904", "WBGene00003476", "Q22712", "WBGene00003476", "Q21733", "WBGene00000904" ] }, "reaction_10543466": { "compartment": "compartment_70101", "id": "reaction_10543466", "reactome": "R-CEL-2187375", "name": "SMAD3 binds STUB1 (CHIP)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10511459", "species_10530864" ], "products": [ "species_10543459" ], "modifiers": [], "additional_components": [ "WBGene00000904", "WBGene00000500", "G5ECY6", "WBGene00000500", "Q21733", "WBGene00000904" ] }, "reaction_10543468": { "compartment": "compartment_70101", "id": "reaction_10543468", "reactome": "R-CEL-2187382", "name": "Degradation of ubiquitinated SMAD3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10543461" ], "products": [], "modifiers": [], "additional_components": [ "Q21733", "WBGene00000904", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727" ] }, "reaction_10543389": { "compartment": "compartment_70101", "id": "reaction_10543389", "reactome": "R-CEL-2176452", "name": "Degradation of ubiquitinated SMAD2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10543387" ], "products": [], "modifiers": [], "additional_components": [ "Q21733", "WBGene00000904", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727" ] }, "reaction_10543310": { "compartment": "compartment_876", "id": "reaction_10543310", "reactome": "R-CEL-2169046", "name": "Degradation of TGF-beta receptor complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10543308" ], "products": [], "modifiers": [], "additional_components": [ "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "P20792", "WBGene00000897", "G5EBY8", "WBGene00006852", "G5EEL5", "WBGene00000936", "G5EDS9", "WBGene00006445" ] }, "reaction_10512054": { "compartment": "compartment_17963", "id": "reaction_10512054", "reactome": "R-CEL-177107", "name": "Secretion and activation of the latent large complex of TGF-beta-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10511397" ], "products": [ "species_10511431" ], "modifiers": [], "additional_components": [ "G5EEL5", "WBGene00000936", "G5EBY8", "WBGene00006852", "G5EBY8", "WBGene00006852", "G5EEL5", "WBGene00000936" ] }, "reaction_10511399": { "compartment": "compartment_20699", "id": "reaction_10511399", "reactome": "R-CEL-170844", "name": "Latent TGF-beta-1 is cleaved by furin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10511389" ], "products": [ "species_10511397" ], "modifiers": [ [ "species_10510315", "catalyst" ] ], "additional_components": [ "G5EBY8", "WBGene00006852", "G5EEL5", "WBGene00000936", "G5EEL5", "WBGene00000936", "G5EBY8", "WBGene00006852", "WBGene00002232" ] }, "reaction_10511464": { "compartment": "compartment_171062", "id": "reaction_10511464", "reactome": "R-CEL-170868", "name": "Activated type I receptor phosphorylates SMAD2/3 directly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10511461" ], "products": [ "species_10511451", "species_29370" ], "modifiers": [ [ "species_10511461", "catalyst" ] ], "additional_components": [ "Q21733", "WBGene00000904", "P20792", "WBGene00000897", "G5EBY8", "WBGene00006852", "G5EEL5", "WBGene00000936", "H2KZI9", "WBGene00000101", "Q21733", "WBGene00000904", "P20792", "WBGene00000897", "G5EBY8", "WBGene00006852", "G5EEL5", "WBGene00000936", "H2KZI9", "WBGene00000101", "Q21733", "WBGene00000904", "P20792", "WBGene00000897", "G5EBY8", "WBGene00006852", "G5EEL5", "WBGene00000936", "H2KZI9", "WBGene00000101" ] }, "reaction_10511419": { "compartment": "compartment_70101", "id": "reaction_10511419", "reactome": "R-CEL-170847", "name": "Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10511404", "species_10511411" ], "products": [ "species_10511417" ], "modifiers": [], "additional_components": [ "WBGene00004858", "WBGene00000904", "Q21733", "WBGene00000904", "P45897", "WBGene00004858" ] }, "reaction_10511455": { "compartment": "compartment_17941", "id": "reaction_10511455", "reactome": "R-CEL-170850", "name": "Phosphorylated SMAD2/3 dissociates from TGFBR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10511451" ], "products": [ "species_10511453", "species_10511411" ], "modifiers": [], "additional_components": [ "Q21733", "WBGene00000904", "P20792", "WBGene00000897", "G5EBY8", "WBGene00006852", "G5EEL5", "WBGene00000936", "H2KZI9", "WBGene00000101", "P20792", "WBGene00000897", "G5EBY8", "WBGene00006852", "G5EEL5", "WBGene00000936", "H2KZI9", "WBGene00000101", "WBGene00000904" ] }, "reaction_10511520": { "compartment": "compartment_70101", "id": "reaction_10511520", "reactome": "R-CEL-173488", "name": "The SMAD2/3:SMAD4 complex transfers to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10511417" ], "products": [ "species_10511518" ], "modifiers": [], "additional_components": [ "Q21733", "WBGene00000904", "P45897", "WBGene00004858", "P45897", "WBGene00004858", "Q21733", "WBGene00000904" ] }, "reaction_10543457": { "compartment": "compartment_7660", "id": "reaction_10543457", "reactome": "R-CEL-2187309", "name": "SMAD2/3:SMAD4 heterotrimer binds SP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10511518", "species_10543453" ], "products": [ "species_10543455" ], "modifiers": [], "additional_components": [ "P45897", "WBGene00004858", "Q21733", "WBGene00000904", "WBGene00012735", "Q9XW26", "WBGene00012735", "P45897", "WBGene00004858", "Q21733", "WBGene00000904" ] }, "reaction_10542739": { "compartment": "compartment_7660", "id": "reaction_10542739", "reactome": "R-CEL-2127257", "name": "SMAD2/3:SMAD4 heterotrimer forms a complex with RBL1, E2F4/5 and DP1/2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10511518", "species_10532108" ], "products": [ "species_10542737" ], "modifiers": [], "additional_components": [ "P45897", "WBGene00004858", "Q21733", "WBGene00000904", "G5EF11", "WBGene00001161", "G5EDT1", "WBGene00003020", "Q22703", "WBGene00001061", "G5EF11", "WBGene00001161", "G5EDT1", "WBGene00003020", "Q22703", "WBGene00001061", "P45897", "WBGene00004858", "Q21733", "WBGene00000904" ] }, "reaction_10543448": { "compartment": "compartment_7660", "id": "reaction_10543448", "reactome": "R-CEL-2186780", "name": "Degradation of Ub-SMAD7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10543446" ], "products": [], "modifiers": [], "additional_components": [ "G5EDS9", "WBGene00006445", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725" ] }, "reaction_10542699": { "compartment": "compartment_70101", "id": "reaction_10542699", "reactome": "R-CEL-2106579", "name": "WWTR1:SMAD translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10542170" ], "products": [ "species_10542697" ], "modifiers": [], "additional_components": [ "Q21733", "WBGene00000904", "P45897", "WBGene00004858", "Q19404", "WBGene00008748", "Q19404", "WBGene00008748", "P45897", "WBGene00004858", "Q21733", "WBGene00000904" ] }, "reaction_10543404": { "compartment": "compartment_7660", "id": "reaction_10543404", "reactome": "R-CEL-2176475", "name": "Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10511518" ], "products": [ "species_113582", "species_10543397" ], "modifiers": [ [ "species_10543401", "catalyst" ] ], "additional_components": [ "P45897", "WBGene00004858", "Q21733", "WBGene00000904", "Q21733", "WBGene00000904", "P45897", "WBGene00004858", "Q9TVL3", "WBGene00000410", "P34424", "WBGene00000508", "P34425", "WBGene00000507", "O17869", "WBGene00009650", "P90866", "WBGene00000409", "Q9TYP2", "WBGene00000506" ] }, "reaction_10542172": { "compartment": "compartment_70101", "id": "reaction_10542172", "reactome": "R-CEL-2031355", "name": "WWTR1 binds SMAD2/3:SMAD4 heterotrimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10541983", "species_10511417" ], "products": [ "species_10542170" ], "modifiers": [], "additional_components": [ "WBGene00008748", "Q21733", "WBGene00000904", "P45897", "WBGene00004858", "Q21733", "WBGene00000904", "P45897", "WBGene00004858", "Q19404", "WBGene00008748" ] }, "reaction_10551215": { "compartment": "compartment_13231", "id": "reaction_10551215", "reactome": "R-CEL-5252001", "name": "ATP1B4 binds SNW1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10551211", "species_10505091" ], "products": [ "species_10551213" ], "modifiers": [], "additional_components": [ "Q93235", "WBGene00007646", "Q9XUG9", "WBGene00008074", "Q9XUY5", "WBGene00010117", "WBGene00004806", "Q22836", "WBGene00004806", "Q93235", "WBGene00007646", "Q9XUG9", "WBGene00008074", "Q9XUY5", "WBGene00010117" ] }, "reaction_10543472": { "compartment": "compartment_70101", "id": "reaction_10543472", "reactome": "R-CEL-2187395", "name": "Dephosphorylated SMAD2/3 translocates to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10516318" ], "products": [ "species_10511457" ], "modifiers": [], "additional_components": [ "WBGene00000904", "WBGene00000904" ] }, "reaction_10543410": { "compartment": "compartment_7660", "id": "reaction_10543410", "reactome": "R-CEL-2176491", "name": "NEDD4L binds phosphorylated linker region of SMAD2/3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10543406", "species_10543397" ], "products": [ "species_10543408" ], "modifiers": [], "additional_components": [ "WBGene00022358", "Q21733", "WBGene00000904", "P45897", "WBGene00004858", "Q21733", "WBGene00000904", "P45897", "WBGene00004858", "A0A061ACQ8", "WBGene00022358" ] }, "reaction_10516323": { "compartment": "compartment_7660", "id": "reaction_10516323", "reactome": "R-CEL-209055", "name": "PPM1A dephosphorylates nuclear SMAD2/3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10516316" ], "products": [ "species_113550", "species_10516318", "species_10516314", "species_10511512" ], "modifiers": [ [ "species_10516316", "catalyst" ] ], "additional_components": [ "Q19775", "WBGene00006460", "P45897", "WBGene00004858", "Q21733", "WBGene00000904", "WBGene00000904", "WBGene00006460", "WBGene00004858", "Q19775", "WBGene00006460", "P45897", "WBGene00004858", "Q21733", "WBGene00000904" ] }, "reaction_10543414": { "compartment": "compartment_7660", "id": "reaction_10543414", "reactome": "R-CEL-2176502", "name": "NEDD4L ubiquitinates SMAD2/3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502318", "species_10543408" ], "products": [ "species_10543406", "species_10543412" ], "modifiers": [], "additional_components": [ "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "Q21733", "WBGene00000904", "P45897", "WBGene00004858", "A0A061ACQ8", "WBGene00022358", "WBGene00022358", "Q21733", "WBGene00000904", "P45897", "WBGene00004858", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725" ] }, "reaction_10543416": { "compartment": "compartment_7660", "id": "reaction_10543416", "reactome": "R-CEL-2176503", "name": "Degradation of SMAD2/3:SMAD4 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10543412" ], "products": [], "modifiers": [], "additional_components": [ "Q21733", "WBGene00000904", "P45897", "WBGene00004858", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725" ] }, "reaction_10528057": { "compartment": "compartment_7660", "id": "reaction_10528057", "reactome": "R-CEL-870477", "name": "Ubiquitinated SMAD4 translocates from the nucleus to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10528053" ], "products": [ "species_10528055" ], "modifiers": [], "additional_components": [ "P45897", "WBGene00004858", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "P45897", "WBGene00004858" ] }, "reaction_10511547": { "compartment": "compartment_7660", "id": "reaction_10511547", "reactome": "R-CEL-173545", "name": "Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10511518" ], "products": [], "modifiers": [ [ "species_10511544", "catalyst" ] ], "additional_components": [ "P45897", "WBGene00004858", "Q21733", "WBGene00000904", "P35129", "WBGene00002344", "P91853", "WBGene00006732", "Q17720", "WBGene00006717", "Q20617", "WBGene00006719" ] }, "reaction_10543470": { "compartment": "compartment_7660", "id": "reaction_10543470", "reactome": "R-CEL-2187388", "name": "PPM1A protein phosphatase binds phosphorylated SMAD2/3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10511518", "species_10516314" ], "products": [ "species_10516316" ], "modifiers": [], "additional_components": [ "P45897", "WBGene00004858", "Q21733", "WBGene00000904", "WBGene00006460", "Q19775", "WBGene00006460", "P45897", "WBGene00004858", "Q21733", "WBGene00000904" ] }, "reaction_10548818": { "compartment": "compartment_876", "id": "reaction_10548818", "reactome": "R-CEL-3928654", "name": "Clathrin internalises EPH:EFN complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10548814", "species_10512890", "species_10512936", "species_10548503", "species_10548802" ], "products": [ "species_10548816" ], "modifiers": [], "additional_components": [ "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "WBGene00001130", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "O61460", "WBGene00006868", "P0DM42", "WBGene00000065", "P10984", "WBGene00000064", "P10986", "WBGene00000066", "P0DM41", "WBGene00000063", "species_29358", "P0DM42", "WBGene00000065", "P10984", "WBGene00000064", "P10986", "WBGene00000066", "P0DM41", "WBGene00000063", "species_29358", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "O61460", "WBGene00006868", "P39055", "WBGene00001130", "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "P35603", "WBGene00001082", "Q19123", "WBGene00000157" ] }, "reaction_10549028": { "compartment": "compartment_70101", "id": "reaction_10549028", "reactome": "R-CEL-4093327", "name": "EPHA binds TIAM1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10548777", "species_10516084" ], "products": [ "species_10548779" ], "modifiers": [], "additional_components": [ "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "O61460", "WBGene00006868", "Q9N3S5", "WBGene00021635", "G5EE56", "WBGene00005077", "WBGene00015704", "O01847", "WBGene00015704", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "O61460", "WBGene00006868", "Q9N3S5", "WBGene00021635", "G5EE56", "WBGene00005077" ] }, "reaction_10548616": { "compartment": "compartment_876", "id": "reaction_10548616", "reactome": "R-CEL-3928604", "name": "SFKs phosphorylate VAV2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10548611" ], "products": [ "species_29370", "species_10548613" ], "modifiers": [ [ "species_10548611", "catalyst" ] ], "additional_components": [ "O61460", "WBGene00006868", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "Q9N3S5", "WBGene00021635", "G5EE56", "WBGene00005077", "Q45FX5", "WBGene00006887", "O61460", "WBGene00006868", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "Q9N3S5", "WBGene00021635", "G5EE56", "WBGene00005077", "Q45FX5", "WBGene00006887", "O61460", "WBGene00006868", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "Q9N3S5", "WBGene00021635", "G5EE56", "WBGene00005077", "Q45FX5", "WBGene00006887" ] }, "reaction_10548857": { "compartment": "compartment_876", "id": "reaction_10548857", "reactome": "R-CEL-3928657", "name": "MMP2,9 cleave EPHB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10548503" ], "products": [ "species_10548844", "species_10548491", "species_10548820" ], "modifiers": [ [ "species_10548854", "catalyst" ] ], "additional_components": [ "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "O61460", "WBGene00006868", "WBGene00006868", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "WBGene00006868", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "Q21182", "WBGene00194737" ] }, "reaction_10548842": { "compartment": "compartment_876", "id": "reaction_10548842", "reactome": "R-CEL-3928656", "name": "gamma-secretase cleaves EPHB2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10548820" ], "products": [ "species_10548830", "species_10548840" ], "modifiers": [ [ "species_10532586", "catalyst" ] ], "additional_components": [ "WBGene00006868", "WBGene00006868", "WBGene00006868", "Q23316", "WBGene00000148", "P52166", "WBGene00004769", "Q01608", "WBGene00004958", "O02100", "WBGene00001985", "Q9U357", "WBGene00003975", "O45876", "WBGene00000147" ] }, "reaction_10548618": { "compartment": "compartment_876", "id": "reaction_10548618", "reactome": "R-CEL-3928607", "name": "p-EPHs bind VAV2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10516077", "species_10548609" ], "products": [ "species_10548611" ], "modifiers": [], "additional_components": [ "WBGene00006887", "O61460", "WBGene00006868", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "Q9N3S5", "WBGene00021635", "G5EE56", "WBGene00005077", "O61460", "WBGene00006868", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "Q9N3S5", "WBGene00021635", "G5EE56", "WBGene00005077", "Q45FX5", "WBGene00006887" ] }, "reaction_10548763": { "compartment": "compartment_876", "id": "reaction_10548763", "reactome": "R-CEL-3928628", "name": "VAV exchanges GTP for GDP on RAC1, activating it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10520575", "species_29438" ], "products": [ "species_29420", "species_10509457" ], "modifiers": [ [ "species_10548613", "catalyst" ] ], "additional_components": [ "species_29420", "Q03206", "ced-10", "species_29438", "Q03206", "ced-10", "O61460", "WBGene00006868", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "Q9N3S5", "WBGene00021635", "G5EE56", "WBGene00005077", "Q45FX5", "WBGene00006887" ] }, "reaction_10548782": { "compartment": "compartment_876", "id": "reaction_10548782", "reactome": "R-CEL-3928642", "name": "TIAM1 exchanges GTP for GDP on RAC1, activating it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10520575", "species_29438" ], "products": [ "species_29420", "species_10509457" ], "modifiers": [ [ "species_10548779", "catalyst" ] ], "additional_components": [ "species_29420", "Q03206", "ced-10", "species_29438", "Q03206", "ced-10", "O01847", "WBGene00015704", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "O61460", "WBGene00006868", "Q9N3S5", "WBGene00021635", "G5EE56", "WBGene00005077" ] }, "reaction_10572371": { "compartment": "compartment_161320", "id": "reaction_10572371", "reactome": "R-CEL-9638078", "name": "HEXB cleaves the terminal GalNAc from keratan sulfate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2105012" ], "products": [ "species_2105010", "species_1605658" ], "modifiers": [ [ "species_10536355", "catalyst" ] ], "additional_components": [ "Q22492", "WBGene00020509" ] }, "reaction_10536644": { "compartment": "compartment_161320", "id": "reaction_10536644", "reactome": "R-CEL-1638053", "name": "HEXA cleaves the terminal GalNAc from keratan sulfate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2105012" ], "products": [ "species_2105010", "species_1605658" ], "modifiers": [ [ "species_10536342", "catalyst" ] ], "additional_components": [ "Q22492", "WBGene00020509" ] }, "reaction_10536555": { "compartment": "compartment_161320", "id": "reaction_10536555", "reactome": "R-CEL-1630306", "name": "GLB1 hydrolyses a glycosaminoglycan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2104997" ], "products": [ "species_1605637", "species_2104995" ], "modifiers": [ [ "species_10536350", "catalyst" ] ], "additional_components": [ "WBGene00011832" ] }, "reaction_10542450": { "compartment": "compartment_17963", "id": "reaction_10542450", "reactome": "R-CEL-2076383", "name": "HS3ST1 sulfates GlcN at C3 in heparan sulfate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_741440", "species_10541552" ], "products": [ "species_742343", "species_10541588" ], "modifiers": [ [ "species_10542445", "catalyst" ] ], "additional_components": [ "G5EGU4", "WBGene00001687", "Q18530", "WBGene00003056", "P50605", "WBGene00004749", "P34710", "unc-6", "P34710", "unc-6", "Q18530", "WBGene00003056", "G5EGU4", "WBGene00001687", "P50605", "WBGene00004749", "WBGene00002030" ] }, "reaction_10542484": { "compartment": "compartment_20699", "id": "reaction_10542484", "reactome": "R-CEL-2076611", "name": "HS3STs sulfate GlcN at C3 in heparan sulfate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_741440", "species_10541552" ], "products": [ "species_742343", "species_10541588" ], "modifiers": [ [ "species_10542481", "catalyst" ] ], "additional_components": [ "G5EGU4", "WBGene00001687", "Q18530", "WBGene00003056", "P50605", "WBGene00004749", "P34710", "unc-6", "P34710", "unc-6", "Q18530", "WBGene00003056", "G5EGU4", "WBGene00001687", "P50605", "WBGene00004749", "Q4TTA0", "WBGene00044303", "Q9TZK5", "WBGene00002030" ] }, "reaction_10541429": { "compartment": "compartment_20699", "id": "reaction_10541429", "reactome": "R-CEL-2022860", "name": "NDST1-4 can sulfate a glucosamine residue in heparan to form heparan sulfate (HS)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_741440", "species_10541379" ], "products": [ "species_742343", "species_10541415" ], "modifiers": [ [ "species_10541420", "catalyst" ] ], "additional_components": [ "P34710", "unc-6", "Q18530", "WBGene00003056", "G5EGU4", "WBGene00001687", "P50605", "WBGene00004749", "G5EGU4", "WBGene00001687", "P34710", "unc-6", "Q18530", "WBGene00003056", "P50605", "WBGene00004749", "WBGene00002028" ] }, "reaction_10542470": { "compartment": "compartment_20699", "id": "reaction_10542470", "reactome": "R-CEL-2076508", "name": "HS2ST1 sulfates IdoA at C2 in heparan sulfate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10541516", "species_741440" ], "products": [ "species_742343", "species_10541552" ], "modifiers": [ [ "species_10542467", "catalyst" ] ], "additional_components": [ "G5EGU4", "WBGene00001687", "Q18530", "WBGene00003056", "P50605", "WBGene00004749", "P34710", "unc-6", "G5EGU4", "WBGene00001687", "Q18530", "WBGene00003056", "P50605", "WBGene00004749", "P34710", "unc-6", "WBGene00002029" ] }, "reaction_10541468": { "compartment": "compartment_20699", "id": "reaction_10541468", "reactome": "R-CEL-2022887", "name": "NDST1-4 N-deacetylates GlcNAc residues in heparan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2022884", "species_10541465" ], "products": [ "species_2022890", "species_10541379" ], "modifiers": [ [ "species_10541420", "catalyst" ] ], "additional_components": [ "G5EGU4", "WBGene00001687", "Q18530", "WBGene00003056", "P50605", "WBGene00004749", "P34710", "unc-6", "P34710", "unc-6", "Q18530", "WBGene00003056", "G5EGU4", "WBGene00001687", "P50605", "WBGene00004749", "WBGene00002028" ] }, "reaction_10542462": { "compartment": "compartment_20699", "id": "reaction_10542462", "reactome": "R-CEL-2076419", "name": "HS6STs sulfate GlcN at C6 in heparan sulfate/heparin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_741440", "species_10541624" ], "products": [ "species_742343", "species_10541656" ], "modifiers": [ [ "species_10542455", "catalyst" ] ], "additional_components": [ "P50605", "WBGene00004749", "G5EGU4", "WBGene00001687", "P34710", "unc-6", "Q18530", "WBGene00003056", "G5EGU4", "WBGene00001687", "Q18530", "WBGene00003056", "P50605", "WBGene00004749", "P34710", "unc-6", "WBGene00002031" ] }, "reaction_10541822": { "compartment": "compartment_17963", "id": "reaction_10541822", "reactome": "R-CEL-2024108", "name": "Some HSPGs are secreted to the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10541658" ], "products": [ "species_10541820" ], "modifiers": [], "additional_components": [ "G5EGU4", "WBGene00001687", "Q18530", "WBGene00003056", "P50605", "WBGene00004749", "P34710", "unc-6", "G5EGU4", "WBGene00001687", "Q18530", "WBGene00003056", "P34710", "unc-6", "P50605", "WBGene00004749" ] }, "reaction_10538116": { "compartment": "compartment_20699", "id": "reaction_10538116", "reactome": "R-CEL-1889978", "name": "B3GALT6 transfers Gal to the tetrasaccharide linker", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10538108", "species_735682" ], "products": [ "species_10537964", "species_205687" ], "modifiers": [ [ "species_10538113", "catalyst" ] ], "additional_components": [ "G5EGU4", "WBGene00001687", "Q18530", "WBGene00003056", "P50605", "WBGene00004749", "P34710", "unc-6", "Q8IG72", "WBGene00016751", "G5EGU4", "WBGene00001687", "Q18530", "WBGene00003056", "P50605", "WBGene00004749", "P34710", "unc-6", "Q8IG72", "WBGene00016751", "WBGene00005020" ] }, "reaction_10537925": { "compartment": "compartment_20699", "id": "reaction_10537925", "reactome": "R-CEL-1878002", "name": "XYLTs transfer Xyl to core protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10537876", "species_742361" ], "products": [ "species_10537915", "species_205687" ], "modifiers": [ [ "species_10537920", "catalyst" ] ], "additional_components": [ "Q18530", "WBGene00003056", "G5EGU4", "WBGene00001687", "Q8IG72", "WBGene00016751", "P34710", "unc-6", "P50605", "WBGene00004749", "P50605", "WBGene00004749", "G5EGU4", "WBGene00001687", "P34710", "unc-6", "Q18530", "WBGene00003056", "Q8IG72", "WBGene00016751", "WBGene00005024" ] }, "reaction_10538069": { "compartment": "compartment_20699", "id": "reaction_10538069", "reactome": "R-CEL-1889955", "name": "B3GAT dimers transfer GlcA to tetrasaccharide linker", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1889970", "species_10537964" ], "products": [ "species_205687", "species_10538003" ], "modifiers": [ [ "species_10538066", "catalyst" ] ], "additional_components": [ "G5EGU4", "WBGene00001687", "Q18530", "WBGene00003056", "P50605", "WBGene00004749", "P34710", "unc-6", "Q8IG72", "WBGene00016751", "Q8IG72", "WBGene00016751", "G5EGU4", "WBGene00001687", "Q18530", "WBGene00003056", "P50605", "WBGene00004749", "P34710", "unc-6", "species_266099", "Q09363", "WBGene00005026", "O17708", "WBGene00008293", "Q9XU73", "WBGene00011781", "O17751", "WBGene00008479", "A0A0K3AUF6", "W07G9.2b", "O62113", "WBGene00008160", "O02304", "WBGene00011650" ] }, "reaction_10538124": { "compartment": "compartment_20699", "id": "reaction_10538124", "reactome": "R-CEL-1889981", "name": "B4GALT7 transfers Gal group to xylosyl-unit of the tetrasaccharide linker", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10537915", "species_735682" ], "products": [ "species_10538108", "species_205687" ], "modifiers": [ [ "species_10538121", "catalyst" ] ], "additional_components": [ "P50605", "WBGene00004749", "G5EGU4", "WBGene00001687", "P34710", "unc-6", "Q18530", "WBGene00003056", "Q8IG72", "WBGene00016751", "G5EGU4", "WBGene00001687", "Q18530", "WBGene00003056", "P50605", "WBGene00004749", "P34710", "unc-6", "Q8IG72", "WBGene00016751", "WBGene00005021" ] }, "reaction_10572364": { "compartment": "compartment_20699", "id": "reaction_10572364", "reactome": "R-CEL-9638064", "name": "B3GAT3 dimer transfers GlcA to tetrasaccharide linker", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1889970", "species_10537964" ], "products": [ "species_205687", "species_10538003" ], "modifiers": [ [ "species_10538064", "catalyst" ] ], "additional_components": [ "G5EGU4", "WBGene00001687", "Q18530", "WBGene00003056", "P50605", "WBGene00004749", "P34710", "unc-6", "Q8IG72", "WBGene00016751", "Q8IG72", "WBGene00016751", "G5EGU4", "WBGene00001687", "Q18530", "WBGene00003056", "P50605", "WBGene00004749", "P34710", "unc-6", "species_266099", "Q09363", "WBGene00005026" ] }, "reaction_10537394": { "compartment": "compartment_161320", "id": "reaction_10537394", "reactome": "R-CEL-1678742", "name": "NAGLU hydrolyses Heparan sulfate chain(4)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2090069" ], "products": [ "species_2090080", "species_1678743" ], "modifiers": [ [ "species_10537391", "catalyst" ] ], "additional_components": [ "WBGene00010722" ] }, "reaction_10542691": { "compartment": "compartment_161320", "id": "reaction_10542691", "reactome": "R-CEL-2090038", "name": "NAGLU hydrolyses heparan chain(2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2090053" ], "products": [ "species_1678743", "species_2065212" ], "modifiers": [ [ "species_10537391", "catalyst" ] ], "additional_components": [ "WBGene00010722" ] }, "reaction_10542693": { "compartment": "compartment_161320", "id": "reaction_10542693", "reactome": "R-CEL-2090079", "name": "GLB1 hydrolyses linker chain(2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2090075" ], "products": [ "species_1605637", "species_2090063" ], "modifiers": [ [ "species_10536350", "catalyst" ] ], "additional_components": [ "WBGene00011832" ] }, "reaction_10541480": { "compartment": "compartment_876", "id": "reaction_10541480", "reactome": "R-CEL-2024084", "name": "HS-GAGs translocate to the lysosome for degradation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10537360" ], "products": [ "species_10537017" ], "modifiers": [], "additional_components": [ "G5EGU4", "WBGene00001687", "Q18530", "WBGene00003056", "P34710", "unc-6", "P50605", "WBGene00004749", "P50605", "WBGene00004749", "P34710", "unc-6", "G5EGU4", "WBGene00001687", "Q18530", "WBGene00003056" ] }, "reaction_10537435": { "compartment": "compartment_161320", "id": "reaction_10537435", "reactome": "R-CEL-1678854", "name": "GUSB tetramer hydrolyses CS/HS precursor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2065212" ], "products": [ "species_1678868", "species_2090075" ], "modifiers": [ [ "species_10537432", "catalyst" ], [ "species_427963", "inhibitor" ] ], "additional_components": [ "Q95Q32", "WBGene00013693" ] }, "reaction_10542856": { "compartment": "compartment_876", "id": "reaction_10542856", "reactome": "R-CEL-2142859", "name": "Growing HA is extruded from the cell by ABCC5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2142896" ], "products": [ "species_2160848" ], "modifiers": [ [ "species_10534273", "catalyst" ] ], "additional_components": [ "species_2162224", "species_2162224", "WBGene00003411" ] }, "reaction_10540904": { "compartment": "compartment_17963", "id": "reaction_10540904", "reactome": "R-CEL-2022065", "name": "DSPGs are secreted", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10540902" ], "products": [ "species_10540868" ], "modifiers": [], "additional_components": [ "Q8IG72", "WBGene00016751", "Q8IG72", "WBGene00016751" ] }, "reaction_10537457": { "compartment": "compartment_161320", "id": "reaction_10537457", "reactome": "R-CEL-1793209", "name": "HYAL1 hydrolyses Chondroitin chains", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2065257" ], "products": [ "species_2065212" ], "modifiers": [ [ "species_10537452", "catalyst" ] ], "additional_components": [ "CHEBI:63512", "CHEBI:63513", "CHEBI:63515", "species_2065239", "WBGene00011923" ] }, "reaction_10536470": { "compartment": "compartment_161320", "id": "reaction_10536470", "reactome": "R-CEL-1606789", "name": "ARSB hydrolyses DS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2065231" ], "products": [ "species_1606845", "species_2065213" ], "modifiers": [ [ "species_10536467", "catalyst" ] ], "additional_components": [ "A0A4V0IJ66", "WBGene00006310", "species_74016" ] }, "reaction_10542695": { "compartment": "compartment_161320", "id": "reaction_10542695", "reactome": "R-CEL-2105001", "name": "HEXA cleaves the terminal GalNAc from DS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2065269" ], "products": [ "species_1605658", "species_2105025" ], "modifiers": [ [ "species_10536342", "catalyst" ] ], "additional_components": [ "Q22492", "WBGene00020509" ] }, "reaction_10537447": { "compartment": "compartment_161320", "id": "reaction_10537447", "reactome": "R-CEL-1793207", "name": "ARSB hydrolyses C4S/C6S chains", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2065251", "species_1605715" ], "products": [ "species_2065239", "species_1606845" ], "modifiers": [ [ "species_10536467", "catalyst" ] ], "additional_components": [ "CHEBI:63512", "CHEBI:63513", "A0A4V0IJ66", "WBGene00006310", "species_74016" ] }, "reaction_10540892": { "compartment": "compartment_984", "id": "reaction_10540892", "reactome": "R-CEL-2022056", "name": "DSPG and CSPG translocate to the lysosome for degradation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10540876", "species_10540868" ], "products": [ "species_10540890", "species_10540884" ], "modifiers": [], "additional_components": [ "Q8IG72", "WBGene00016751", "Q8IG72", "WBGene00016751", "Q8IG72", "WBGene00016751", "Q8IG72", "WBGene00016751" ] }, "reaction_10572367": { "compartment": "compartment_161320", "id": "reaction_10572367", "reactome": "R-CEL-9638075", "name": "HEXB cleaves the terminal GalNAc from DS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2065269" ], "products": [ "species_1605658", "species_2105025" ], "modifiers": [ [ "species_10536355", "catalyst" ] ], "additional_components": [ "Q22492", "WBGene00020509" ] }, "reaction_10541472": { "compartment": "compartment_17963", "id": "reaction_10541472", "reactome": "R-CEL-2022911", "name": "CSPG is secreted", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10541470" ], "products": [ "species_10540876" ], "modifiers": [], "additional_components": [ "Q8IG72", "WBGene00016751", "Q8IG72", "WBGene00016751" ] }, "reaction_10572304": { "compartment": "compartment_20699", "id": "reaction_10572304", "reactome": "R-CEL-9632034", "name": "CHSY1 transfers GlcA to chondroitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1889970", "species_10538300" ], "products": [ "species_10538309", "species_205687" ], "modifiers": [ [ "species_10572298", "catalyst" ] ], "additional_components": [ "WBGene00016751", "WBGene00016751", "WBGene00005023" ] }, "reaction_10538324": { "compartment": "compartment_20699", "id": "reaction_10538324", "reactome": "R-CEL-1971487", "name": "CHPF,CHSY3 transfer GalNAc to chondroitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_735700", "species_10538309" ], "products": [ "species_10538303", "species_205687" ], "modifiers": [ [ "species_10538321", "catalyst" ] ], "additional_components": [ "WBGene00016751", "WBGene00016751", "P45895", "WBGene00003253", "Q7Z1Z1", "WBGene00005023" ] }, "reaction_10538329": { "compartment": "compartment_20699", "id": "reaction_10538329", "reactome": "R-CEL-1971491", "name": "CHPF,CHPF2,CHSY3 transfer GlcA to chondroitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1889970", "species_10538300" ], "products": [ "species_10538309", "species_205687" ], "modifiers": [ [ "species_10538321", "catalyst" ] ], "additional_components": [ "WBGene00016751", "WBGene00016751", "P45895", "WBGene00003253", "Q7Z1Z1", "WBGene00005023" ] }, "reaction_10572301": { "compartment": "compartment_20699", "id": "reaction_10572301", "reactome": "R-CEL-9632033", "name": "CHSY1 transfers GalNAc to chondroitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_735700", "species_10538309" ], "products": [ "species_10538303", "species_205687" ], "modifiers": [ [ "species_10572298", "catalyst" ] ], "additional_components": [ "WBGene00016751", "WBGene00016751", "WBGene00005023" ] }, "reaction_10510178": { "compartment": "compartment_5460", "id": "reaction_10510178", "reactome": "R-CEL-163310", "name": "TFAM binds to mitochondrial promoters", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10510174", "species_163305" ], "products": [ "species_10510176" ], "modifiers": [], "additional_components": [ "WBGene00001975", "Q94234", "WBGene00001975" ] }, "reaction_10508532": { "compartment": "compartment_876", "id": "reaction_10508532", "reactome": "R-CEL-109701", "name": "PDPK1 binds PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179838", "species_10508528" ], "products": [ "species_10508530" ], "modifiers": [], "additional_components": [ "WBGene00021022", "Q9UA62", "WBGene00021022", "species_179838" ] }, "reaction_10508551": { "compartment": "compartment_70101", "id": "reaction_10508551", "reactome": "R-CEL-109702", "name": "PDPK1 phosphorylates AKT2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10508521" ], "products": [ "species_29370", "species_10508548" ], "modifiers": [ [ "species_10508530", "catalyst" ] ], "additional_components": [ "Q9XTG7", "WBGene00000103", "G4S4W1", "WBGene00016980", "Q17941", "WBGene00000102", "species_179838", "Q9XTG7", "WBGene00000103", "G4S4W1", "WBGene00016980", "Q17941", "WBGene00000102", "species_179838", "Q9UA62", "WBGene00021022", "species_179838" ] }, "reaction_10508523": { "compartment": "compartment_876", "id": "reaction_10508523", "reactome": "R-CEL-109700", "name": "AKT2 binds PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179838", "species_10508519" ], "products": [ "species_10508521", "species_10508500" ], "modifiers": [], "additional_components": [ "G5EED4", "WBGene00010700", "Q9XTG7", "WBGene00000103", "G4S4W1", "WBGene00016980", "Q17941", "WBGene00000102", "Q9XTG7", "WBGene00000103", "G4S4W1", "WBGene00016980", "Q17941", "WBGene00000102", "species_179838", "WBGene00010700" ] }, "reaction_10510068": { "compartment": "compartment_70101", "id": "reaction_10510068", "reactome": "R-CEL-162425", "name": "p-S295-PDE3B hydrolyses cAMP to AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_30389" ], "products": [ "species_76577" ], "modifiers": [ [ "species_10510065", "catalyst" ] ], "additional_components": [ "WBGene00008443" ] }, "reaction_10508495": { "compartment": "compartment_70101", "id": "reaction_10508495", "reactome": "R-CEL-109699", "name": "PI3K-containing complexes phosphorylate PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10508492", "catalyst" ] ], "additional_components": [ "G5EDP9", "WBGene00000001", "A0A1I6CMA1", "WBGene00020678", "G5EGT9", "WBGene00003007", "P29355", "WBGene00004774", "G5EDJ4", "WBGene00004928" ] }, "reaction_10513499": { "compartment": "compartment_876", "id": "reaction_10513499", "reactome": "R-CEL-194518", "name": "RhoA is activated by nucleotide exchange and inhibits axonal growth", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509486" ], "products": [ "species_10509488" ], "modifiers": [ [ "species_10513496", "catalyst" ] ], "additional_components": [ "Q22038", "WBGene00004357", "species_29420", "Q22038", "WBGene00004357", "species_29438", "WBGene00006496" ] }, "reaction_10522807": { "compartment": "compartment_7660", "id": "reaction_10522807", "reactome": "R-CEL-427514", "name": "eNoSC deacetylates histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10522790", "species_427523" ], "products": [ "species_427497", "species_427498", "species_10517072" ], "modifiers": [ [ "species_10522804", "catalyst" ] ], "additional_components": [ "P62784", "WBGene00001875", "Q10453", "WBGene00001945", "K7ZUH9", "WBGene00001914", "P62784", "WBGene00001875", "K7ZUH9", "WBGene00001914", "Q10453", "WBGene00001945", "Q21921", "WBGene00004800", "O44410", "WBGene00020296", "P62784", "WBGene00001875", "K7ZUH9", "WBGene00001914", "Q10453", "WBGene00001945" ] }, "reaction_10522810": { "compartment": "compartment_7660", "id": "reaction_10522810", "reactome": "R-CEL-427527", "name": "eNoSC dimethylates histone H3 at lysine-9", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10517072" ], "products": [ "species_77502", "species_10507005" ], "modifiers": [ [ "species_10522804", "catalyst" ] ], "additional_components": [ "P62784", "WBGene00001875", "K7ZUH9", "WBGene00001914", "Q10453", "WBGene00001945", "P62784", "WBGene00001875", "K7ZUH9", "WBGene00001914", "Q10453", "WBGene00001945", "Q21921", "WBGene00004800", "O44410", "WBGene00020296", "P62784", "WBGene00001875", "K7ZUH9", "WBGene00001914", "Q10453", "WBGene00001945" ] }, "reaction_10522776": { "compartment": "compartment_7660", "id": "reaction_10522776", "reactome": "R-CEL-427337", "name": "MBD2 binds methylcytosine in chromatin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10522772", "species_10522770" ], "products": [ "species_10522774" ], "modifiers": [], "additional_components": [ "P62784", "WBGene00001875", "K7ZUH9", "WBGene00001914", "Q10453", "WBGene00001945", "WBGene00023409", "G5ECR1", "WBGene00023409", "P62784", "WBGene00001875", "K7ZUH9", "WBGene00001914", "Q10453", "WBGene00001945" ] }, "reaction_10547602": { "compartment": "compartment_70101", "id": "reaction_10547602", "reactome": "R-CEL-3371435", "name": "Constitutive phosphorylation by GSK3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10547597", "species_113592" ], "products": [ "species_29370", "species_10547600" ], "modifiers": [ [ "species_10513574", "catalyst" ] ], "additional_components": [ "WBGene00002004", "WBGene00002004", "Q9U2Q9", "WBGene00001746", "Q09595", "WBGene00010991", "Q93372", "WBGene00010991" ] }, "reaction_10547682": { "compartment": "compartment_7660", "id": "reaction_10547682", "reactome": "R-CEL-3371537", "name": "DBC1 binds SIRT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10547678", "species_10522802" ], "products": [ "species_10547680" ], "modifiers": [], "additional_components": [ "Y37A1B.1a", "WBGene00004800", "Q21921", "WBGene00004800", "A0A0S4XR43", "Y37A1B.1a" ] }, "reaction_10551170": { "compartment": "compartment_7660", "id": "reaction_10551170", "reactome": "R-CEL-5251955", "name": "HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10551131" ], "products": [ "species_113550", "species_10551129", "species_10551155" ], "modifiers": [ [ "species_10551167", "catalyst" ] ], "additional_components": [ "species_29358", "G5EC99", "WBGene00009691", "G5ECU5", "WBGene00009691", "O45246", "WBGene00002026", "K8ERU5", "WBGene00018328", "WBGene00018328", "G5EC99", "WBGene00009691", "G5ECU5", "WBGene00009691", "O45246", "WBGene00002026", "species_113582", "Q9TY07", "WBGene00001042", "Q94216", "WBGene00001029" ] }, "reaction_10551203": { "compartment": "compartment_70101", "id": "reaction_10551203", "reactome": "R-CEL-5251959", "name": "HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10551073" ], "products": [ "species_29372", "species_10551194" ], "modifiers": [ [ "species_10551200", "catalyst" ] ], "additional_components": [ "G5ECU5", "WBGene00009691", "O45246", "WBGene00002026", "G5EC99", "WBGene00009691", "species_29358", "G5ECU5", "WBGene00009691", "O45246", "WBGene00002026", "G5EC99", "WBGene00009691", "species_113582", "Q9TY07", "WBGene00001042", "Q94216", "WBGene00001029" ] }, "reaction_10551077": { "compartment": "compartment_70101", "id": "reaction_10551077", "reactome": "R-CEL-5251942", "name": "Hikeshi binds HSP70s:ATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10551014", "species_10551073" ], "products": [ "species_10551075" ], "modifiers": [], "additional_components": [ "WBGene00018328", "G5ECU5", "WBGene00009691", "O45246", "WBGene00002026", "G5EC99", "WBGene00009691", "species_29358", "G5ECU5", "WBGene00009691", "O45246", "WBGene00002026", "G5EC99", "WBGene00009691", "species_29358", "K8ERU5", "WBGene00018328" ] }, "reaction_10549720": { "compartment": "compartment_70101", "id": "reaction_10549720", "reactome": "R-CEL-4793911", "name": "MAPKAPK2 phosphorylates HSF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10547597", "species_113592" ], "products": [ "species_29370", "species_10549717" ], "modifiers": [ [ "species_10512624", "catalyst" ] ], "additional_components": [ "WBGene00002004", "WBGene00002004", "Q21360", "WBGene00010681", "Q965G5", "WBGene00007007" ] }, "reaction_10551241": { "compartment": "compartment_70101", "id": "reaction_10551241", "reactome": "R-CEL-5252079", "name": "HSP110s exchange ATP for ADP on HSP70s:ADP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10551194", "species_113592" ], "products": [ "species_29370", "species_10551073" ], "modifiers": [ [ "species_10551231", "catalyst" ], [ "species_10551239", "inhibitor" ] ], "additional_components": [ "G5ECU5", "WBGene00009691", "O45246", "WBGene00002026", "G5EC99", "WBGene00009691", "species_113582", "G5ECU5", "WBGene00009691", "O45246", "WBGene00002026", "G5EC99", "WBGene00009691", "species_29358", "Q05036", "WBGene00016250", "O44739", "WBGene00000236", "O61980", "WBGene00006760", "G5EE04", "WBGene00011735" ] }, "reaction_10547675": { "compartment": "compartment_70101", "id": "reaction_10547675", "reactome": "R-CEL-3371531", "name": "Constitutive phosphorylation by pERK1/2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10547597", "species_113592" ], "products": [ "species_29370", "species_10547673" ], "modifiers": [ [ "species_10542082", "catalyst" ] ], "additional_components": [ "WBGene00002004", "WBGene00002004", "P39745", "WBGene00003401" ] }, "reaction_10547692": { "compartment": "compartment_7660", "id": "reaction_10547692", "reactome": "R-CEL-3371567", "name": "DBC1 is phosphorylated by ATM/ART", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10547684" ], "products": [ "species_113582", "species_10547678" ], "modifiers": [ [ "species_10547689", "catalyst" ] ], "additional_components": [ "Y37A1B.1a", "Y37A1B.1a", "WBGene00000226" ] }, "reaction_10549888": { "compartment": "compartment_7660", "id": "reaction_10549888", "reactome": "R-CEL-5082409", "name": "Dissociation of HSF1:HSP90 complex in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10549886" ], "products": [ "species_10549884", "species_10549878", "species_10549859" ], "modifiers": [], "additional_components": [ "G5EFT5", "WBGene00002004", "Q23280", "WBGene00022599", "Q18688", "WBGene00000915", "Q18688", "WBGene00000915", "WBGene00022599", "WBGene00002004" ] }, "reaction_10547717": { "compartment": "compartment_70101", "id": "reaction_10547717", "reactome": "R-CEL-3371591", "name": "Trimerization of cytosolic HSF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10547597" ], "products": [ "species_10547664" ], "modifiers": [ [ "species_10509904", "catalyst" ] ], "additional_components": [ "WBGene00002004", "G5EFT5", "WBGene00002004", "WBGene00001168" ] }, "reaction_10549861": { "compartment": "compartment_7660", "id": "reaction_10549861", "reactome": "R-CEL-5082391", "name": "Trimerization of HSF1 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10549859" ], "products": [ "species_10547668" ], "modifiers": [], "additional_components": [ "WBGene00002004", "G5EFT5", "WBGene00002004" ] }, "reaction_10547670": { "compartment": "compartment_70101", "id": "reaction_10547670", "reactome": "R-CEL-3371527", "name": "HSF1 trimer translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10547664" ], "products": [ "species_10547668" ], "modifiers": [], "additional_components": [ "G5EFT5", "WBGene00002004", "G5EFT5", "WBGene00002004" ] }, "reaction_10551291": { "compartment": "compartment_70101", "id": "reaction_10551291", "reactome": "R-CEL-5324632", "name": "Dissociation of cytosolic HSF1:HSP90:HDAC6:PTGES3 upon sensing protein aggregates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5324631", "species_10551286" ], "products": [ "species_10547597", "species_10517708", "species_10551288", "species_10547652" ], "modifiers": [ [ "species_10551286", "catalyst" ] ], "additional_components": [ "Q18688", "WBGene00000915", "P54812", "WBGene00008053", "Q23280", "WBGene00022599", "G5EFT5", "WBGene00002004", "Q20296", "WBGene00018319", "WBGene00002004", "WBGene00022599", "P54812", "WBGene00008053", "Q20296", "WBGene00018319", "Q18688", "WBGene00000915", "Q18688", "WBGene00000915", "P54812", "WBGene00008053", "Q23280", "WBGene00022599", "G5EFT5", "WBGene00002004", "Q20296", "WBGene00018319" ] }, "reaction_10547709": { "compartment": "compartment_70101", "id": "reaction_10547709", "reactome": "R-CEL-3371586", "name": "Dissociation of cytosolic HSF1:HSP90 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10547707" ], "products": [ "species_10547597", "species_10517708", "species_10547652" ], "modifiers": [], "additional_components": [ "Q18688", "WBGene00000915", "Q23280", "WBGene00022599", "G5EFT5", "WBGene00002004", "WBGene00002004", "WBGene00022599", "Q18688", "WBGene00000915" ] }, "reaction_10549857": { "compartment": "compartment_7660", "id": "reaction_10549857", "reactome": "R-CEL-5082387", "name": "Phosphorylation of HSF1 at Ser230 induces transactivation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10547668" ], "products": [ "species_113582", "species_10549835" ], "modifiers": [ [ "species_10549854", "catalyst" ] ], "additional_components": [ "G5EFT5", "WBGene00002004", "G5EFT5", "WBGene00002004", "O62305", "WBGene00006779" ] }, "reaction_10549842": { "compartment": "compartment_7660", "id": "reaction_10549842", "reactome": "R-CEL-5082356", "name": "HSF1-mediated gene expression", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10549772" ], "products": [ "species_10549830" ], "modifiers": [ [ "species_10549840", "catalyst" ], [ "species_10549835", "catalyst" ] ], "additional_components": [ "G5EFT5", "WBGene00002004", "Q9U3B7", "WBGene00002002", "Q20660", "WBGene00002021", "Q19227", "WBGene00014233", "P06581", "WBGene00002018", "B0M0L8", "WBGene00002024", "Q19228", "WBGene00014233", "P06582", "WBGene00002016", "G5EF99", "WBGene00014233", "Q20363", "WBGene00004798", "P34696", "WBGene00002015", "P02513", "WBGene00002019", "P09446", "WBGene00002005", "G5EC99", "WBGene00009691", "G5ECU5", "WBGene00009691", "O45246", "WBGene00002026", "Q18688", "WBGene00000915", "G5EFT5", "WBGene00002004", "G5EFT5", "WBGene00002004" ] }, "reaction_10549876": { "compartment": "compartment_7660", "id": "reaction_10549876", "reactome": "R-CEL-5082405", "name": "Phosphorylation of HSF1 at Ser326 induces transactivation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10547668" ], "products": [ "species_113582", "species_10549840" ], "modifiers": [ [ "species_10549873", "catalyst" ] ], "additional_components": [ "G5EFT5", "WBGene00002004", "G5EFT5", "WBGene00002004", "P91040", "WBGene00015697", "Q95Q95", "WBGene00002583", "Q68TI8", "WBGene00000911" ] }, "reaction_10547705": { "compartment": "compartment_7660", "id": "reaction_10547705", "reactome": "R-CEL-3371582", "name": "HSBP1 binds HSF1 trimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10547701", "species_10547668" ], "products": [ "species_10547703" ], "modifiers": [], "additional_components": [ "Q9U3B7", "WBGene00002002", "G5EFT5", "WBGene00002004", "G5EFT5", "WBGene00002004", "Q9U3B7", "WBGene00002002" ] }, "reaction_10551274": { "compartment": "compartment_7660", "id": "reaction_10551274", "reactome": "R-CEL-5324617", "name": "HSP90:FKBP4:PTGES3 binds HSF1 trimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10551270", "species_10547668" ], "products": [ "species_10551272" ], "modifiers": [], "additional_components": [ "O45418", "WBGene00001431", "Q23280", "WBGene00022599", "Q18688", "WBGene00000915", "G5EFT5", "WBGene00002004", "O45418", "WBGene00001431", "G5EFT5", "WBGene00002004", "Q23280", "WBGene00022599", "Q18688", "WBGene00000915" ] }, "reaction_10535090": { "compartment": "compartment_70616", "id": "reaction_10535090", "reactome": "R-CEL-1483165", "name": "PA is converted to CDP-DAG by CDS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524101", "species_110577" ], "products": [ "species_159450", "species_1524064" ], "modifiers": [ [ "species_10535087", "catalyst" ] ], "additional_components": [ "WBGene00016384" ] }, "reaction_10535537": { "compartment": "compartment_984", "id": "reaction_10535537", "reactome": "R-CEL-1566981", "name": "Fibronectin degradation by MMP1, 3, 7, 12, 13, 19, CTSS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10517394" ], "products": [ "species_10535515" ], "modifiers": [ [ "species_10535534", "catalyst" ] ], "additional_components": [ "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "Q21182", "WBGene00194737", "O45734", "WBGene00000776", "Q23030", "WBGene00019986", "Q93512", "WBGene00019986" ] }, "reaction_10536417": { "compartment": "compartment_17963", "id": "reaction_10536417", "reactome": "R-CEL-1605825", "name": "MT-MMPs are sorted to the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10536012" ], "products": [ "species_10536415" ], "modifiers": [], "additional_components": [ "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "Q21182", "WBGene00194737", "A0A0K3ARD1", "WBGene00194737", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "Q21182", "WBGene00194737" ] }, "reaction_10536167": { "compartment": "compartment_984", "id": "reaction_10536167", "reactome": "R-CEL-1604731", "name": "Autocatalytic activation of MMP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10535663" ], "products": [ "species_10536164", "species_10534164" ], "modifiers": [ [ "species_10535663", "catalyst" ] ], "additional_components": [ "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "Q21182", "WBGene00194737", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "Q21182", "WBGene00194737", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "Q21182", "WBGene00194737" ] }, "reaction_10536136": { "compartment": "compartment_984", "id": "reaction_10536136", "reactome": "R-CEL-1604690", "name": "Activation of MMP9 intermediate form by MMPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10535755" ], "products": [ "species_10536134", "species_10534192" ], "modifiers": [ [ "species_10535771", "catalyst" ] ], "additional_components": [ "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "Q21182", "WBGene00194737", "A0A0K3ARD1", "WBGene00194737", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "Q21182", "WBGene00194737", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "G5EBU3", "WBGene00016283", "Q21182", "WBGene00194737", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "A0A0K3ARD1", "WBGene00194737" ] }, "reaction_10535593": { "compartment": "compartment_984", "id": "reaction_10535593", "reactome": "R-CEL-1592297", "name": "Full activation of MMP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10535588" ], "products": [ "species_10534120" ], "modifiers": [ [ "species_10535590", "catalyst" ] ], "additional_components": [ "O62390", "WBGene00194737", "Q21182", "WBGene00194737", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "G5EBU3", "WBGene00016283", "Q21182", "WBGene00194737", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737" ] }, "reaction_10536014": { "compartment": "compartment_17963", "id": "reaction_10536014", "reactome": "R-CEL-1602466", "name": "Activation of MT-MMPs by FURIN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10535950" ], "products": [ "species_10536012" ], "modifiers": [ [ "species_10510315", "catalyst" ] ], "additional_components": [ "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "Q21182", "WBGene00194737", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "Q21182", "WBGene00194737", "A0A0K3ARD1", "WBGene00194737", "WBGene00002232" ] }, "reaction_10536047": { "compartment": "compartment_17963", "id": "reaction_10536047", "reactome": "R-CEL-1602484", "name": "Activation of proMMP11 by FURIN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10536045" ], "products": [ "species_10534227" ], "modifiers": [ [ "species_10510315", "catalyst" ] ], "additional_components": [ "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "Q21182", "WBGene00194737", "Q21182", "WBGene00194737", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "WBGene00002232" ] }, "reaction_10536244": { "compartment": "compartment_984", "id": "reaction_10536244", "reactome": "R-CEL-1604732", "name": "Autocatalytic activation of proMMP13", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10536197" ], "products": [ "species_10534136", "species_10536241" ], "modifiers": [ [ "species_10536197", "catalyst" ], [ "species_10535571", "inhibitor" ] ], "additional_components": [ "Q21182", "WBGene00194737", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "Q21182", "WBGene00194737", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "Q21182", "WBGene00194737", "Q21182", "WBGene00194737", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "WBGene00000702" ] }, "reaction_10535573": { "compartment": "compartment_984", "id": "reaction_10535573", "reactome": "R-CEL-1592278", "name": "Autocatalytic activation of proMMP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10535551" ], "products": [ "species_10535565", "species_10534150" ], "modifiers": [ [ "species_10535551", "catalyst" ], [ "species_10535571", "inhibitor" ] ], "additional_components": [ "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "Q21182", "WBGene00194737", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "Q21182", "WBGene00194737", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "Q21182", "WBGene00194737", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "Q21182", "WBGene00194737", "WBGene00000702" ] }, "reaction_10536277": { "compartment": "compartment_984", "id": "reaction_10536277", "reactome": "R-CEL-1604741", "name": "Initial activation of proMMP13 by MMP14 (MT1-MMP)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10536061" ], "products": [ "species_10536181", "species_10536258" ], "modifiers": [ [ "species_10536274", "catalyst" ] ], "additional_components": [ "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "Q21182", "WBGene00194737", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "Q21182", "WBGene00194737", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "Q21182", "WBGene00194737", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283" ] }, "reaction_10536120": { "compartment": "compartment_984", "id": "reaction_10536120", "reactome": "R-CEL-1604359", "name": "Initial activation of proMMP2 by MMP1, 7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10536103" ], "products": [ "species_10535551", "species_10536117" ], "modifiers": [ [ "species_10534120", "catalyst" ] ], "additional_components": [ "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "Q21182", "WBGene00194737", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "Q21182", "WBGene00194737", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "G5EBU3", "WBGene00016283", "Q21182", "WBGene00194737", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "A0A0K3ARD1", "WBGene00194737" ] }, "reaction_10536312": { "compartment": "compartment_984", "id": "reaction_10536312", "reactome": "R-CEL-1604752", "name": "Initial activation of proMMP13 by MMP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10536061" ], "products": [ "species_10536291", "species_10536195" ], "modifiers": [ [ "species_10536309", "catalyst" ] ], "additional_components": [ "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "Q21182", "WBGene00194737", "Q21182", "WBGene00194737", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "Q21182", "WBGene00194737", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "Q93512", "WBGene00019986", "O45734", "WBGene00000776", "Q23030", "WBGene00019986", "O62390", "WBGene00194737", "Q21182", "WBGene00194737", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987" ] }, "reaction_10535774": { "compartment": "compartment_984", "id": "reaction_10535774", "reactome": "R-CEL-1592436", "name": "Initial activation of proMMP9 by MMPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10535741" ], "products": [ "species_10535755", "species_10535769" ], "modifiers": [ [ "species_10535771", "catalyst" ] ], "additional_components": [ "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "Q21182", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "Q21182", "WBGene00194737", "A0A0K3ARD1", "WBGene00194737", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "Q21182", "WBGene00194737", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "O62390", "WBGene00194737", "G5EBU3", "WBGene00016283", "Q21182", "WBGene00194737", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "A0A0K3ARD1", "WBGene00194737" ] }, "reaction_10536031": { "compartment": "compartment_984", "id": "reaction_10536031", "reactome": "R-CEL-1602473", "name": "Autocatalytic activation of MMP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10535621" ], "products": [ "species_10536028", "species_10535588" ], "modifiers": [ [ "species_10535621", "catalyst" ] ], "additional_components": [ "O62390", "WBGene00194737", "Q21182", "WBGene00194737", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "Q21182", "WBGene00194737", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "Q21182", "WBGene00194737", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987" ] }, "reaction_10534261": { "compartment": "compartment_984", "id": "reaction_10534261", "reactome": "R-CEL-1454781", "name": "MMP1,3,13 (2, 7-12, 19) binding by Alpha-2 macroglubulin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10534199", "species_10534257" ], "products": [ "species_10534259" ], "modifiers": [], "additional_components": [ "K8F7Z5", "WBGene00008735", "Q7YTU0", "WBGene00013969", "O62390", "WBGene00194737", "Q21182", "WBGene00194737", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "Q21182", "WBGene00194737", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "K8F7Z5", "WBGene00008735", "Q7YTU0", "WBGene00013969" ] }, "reaction_10568695": { "compartment": "compartment_984", "id": "reaction_10568695", "reactome": "R-CEL-8942302", "name": "MMP13 cleaves OPTC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10568612" ], "products": [ "species_10568618", "species_10568692" ], "modifiers": [ [ "species_10534136", "catalyst" ] ], "additional_components": [ "WBGene00019351", "WBGene00019351", "WBGene00019351", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "Q21182", "WBGene00194737", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283" ] }, "reaction_10544776": { "compartment": "compartment_876", "id": "reaction_10544776", "reactome": "R-CEL-2533950", "name": "Fibronectin degradation by MMP14, TMPRSS6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10517394" ], "products": [ "species_10535515" ], "modifiers": [ [ "species_10534376", "catalyst" ] ], "additional_components": [ "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "Q21182", "WBGene00194737", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283" ] }, "reaction_10548232": { "compartment": "compartment_876", "id": "reaction_10548232", "reactome": "R-CEL-3788061", "name": "Fibronectin degradation by ADAM8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10517394" ], "products": [ "species_10548207" ], "modifiers": [ [ "species_10548229", "catalyst" ] ], "additional_components": [ "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769", "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q19844", "WBGene00270320", "A0A1D3PCM0", "WBGene00270320", "G5EDW5", "WBGene00000074", "G5EFD5", "WBGene00006804" ] }, "reaction_10535392": { "compartment": "compartment_984", "id": "reaction_10535392", "reactome": "R-CEL-1564164", "name": "Collagen type V degradation by MMP2,9,10", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10519175" ], "products": [ "species_10535387" ], "modifiers": [ [ "species_10535389", "catalyst" ] ], "additional_components": [ "O76368", "WBGene00000674", "Q09457", "WBGene00000251", "Q9N4U2", "WBGene00000647", "P17140", "WBGene00002280", "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689", "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689", "O76368", "WBGene00000674", "Q09457", "WBGene00000251", "Q9N4U2", "WBGene00000647", "P17140", "WBGene00002280", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "Q21182", "WBGene00194737" ] }, "reaction_10543302": { "compartment": "compartment_984", "id": "reaction_10543302", "reactome": "R-CEL-2168923", "name": "Collagen type XVIII endostatin release", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10543225" ], "products": [ "species_10543255", "species_10543253" ], "modifiers": [ [ "species_10543299", "catalyst" ] ], "additional_components": [ "Q19368", "WBGene00000702", "WBGene00000702", "Q19368", "WBGene00000702", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "Q21182", "WBGene00194737", "P43510", "WBGene00000786", "O45734", "WBGene00000776", "Q23030", "WBGene00019986", "Q93512", "WBGene00019986" ] }, "reaction_10535495": { "compartment": "compartment_984", "id": "reaction_10535495", "reactome": "R-CEL-1564169", "name": "Collagen type VIII degradation by MMP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10535492" ], "products": [ "species_10533894" ], "modifiers": [ [ "species_10534120", "catalyst" ] ], "additional_components": [ "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689", "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689", "O62390", "WBGene00194737", "G5EBU3", "WBGene00016283", "Q21182", "WBGene00194737", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "A0A0K3ARD1", "WBGene00194737" ] }, "reaction_10544552": { "compartment": "compartment_984", "id": "reaction_10544552", "reactome": "R-CEL-2471621", "name": "Endostatin degradation by cathepsins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10543255" ], "products": [], "modifiers": [ [ "species_10544549", "catalyst" ] ], "additional_components": [ "WBGene00000702", "P43510", "WBGene00000786", "O45734", "WBGene00000776", "Q23030", "WBGene00019986", "Q93512", "WBGene00019986", "Q21966", "WBGene00000217" ] }, "reaction_10557611": { "compartment": "compartment_5460", "id": "reaction_10557611", "reactome": "R-CEL-5696408", "name": "PXLP-K278-PHYKPL tetramer hydrolyses 5PHL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5696409", "species_113521" ], "products": [ "species_113548", "species_5693978", "species_113556" ], "modifiers": [ [ "species_10557608", "catalyst" ] ], "additional_components": [ "P91408", "WBGene00020139" ] }, "reaction_10534379": { "compartment": "compartment_984", "id": "reaction_10534379", "reactome": "R-CEL-1474210", "name": "Collagen type III degradation by MMP14", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10518945" ], "products": [ "species_10533696" ], "modifiers": [ [ "species_10534376", "catalyst" ] ], "additional_components": [ "Q9N4U2", "WBGene00000647", "O76368", "WBGene00000674", "Q09457", "WBGene00000251", "Q9N4U2", "WBGene00000647", "O76368", "WBGene00000674", "Q09457", "WBGene00000251", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "Q21182", "WBGene00194737", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283" ] }, "reaction_10534384": { "compartment": "compartment_984", "id": "reaction_10534384", "reactome": "R-CEL-1474213", "name": "Collagen type III degradation by MMP1,8,9,13", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10518945" ], "products": [ "species_10533696" ], "modifiers": [ [ "species_10534381", "catalyst" ] ], "additional_components": [ "Q9N4U2", "WBGene00000647", "O76368", "WBGene00000674", "Q09457", "WBGene00000251", "Q9N4U2", "WBGene00000647", "O76368", "WBGene00000674", "Q09457", "WBGene00000251", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "Q21182", "WBGene00194737" ] }, "reaction_10543312": { "compartment": "compartment_984", "id": "reaction_10543312", "reactome": "R-CEL-2172433", "name": "Collagen type XIX degradation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10542657" ], "products": [], "modifiers": [], "additional_components": [ "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689" ] }, "reaction_10544561": { "compartment": "compartment_984", "id": "reaction_10544561", "reactome": "R-CEL-2473584", "name": "Collagen type III degradation by MMP15", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10518945" ], "products": [ "species_10533696" ], "modifiers": [ [ "species_10536395", "catalyst" ] ], "additional_components": [ "Q9N4U2", "WBGene00000647", "O76368", "WBGene00000674", "Q09457", "WBGene00000251", "Q9N4U2", "WBGene00000647", "O76368", "WBGene00000674", "Q09457", "WBGene00000251", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "Q21182", "WBGene00194737", "A0A0K3ARD1", "WBGene00194737" ] }, "reaction_10544563": { "compartment": "compartment_876", "id": "reaction_10544563", "reactome": "R-CEL-2473594", "name": "Collagen type II degradation by MMP15", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10517286" ], "products": [ "species_10533498" ], "modifiers": [ [ "species_10536395", "catalyst" ] ], "additional_components": [ "O76368", "WBGene00000674", "Q09457", "WBGene00000251", "Q9N4U2", "WBGene00000647", "Q09457", "WBGene00000251", "Q9N4U2", "WBGene00000647", "O76368", "WBGene00000674", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "Q21182", "WBGene00194737", "A0A0K3ARD1", "WBGene00194737" ] }, "reaction_10544565": { "compartment": "compartment_876", "id": "reaction_10544565", "reactome": "R-CEL-2473596", "name": "Collagen type I degradation by MMP15", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509625" ], "products": [ "species_10533300" ], "modifiers": [ [ "species_10536395", "catalyst" ] ], "additional_components": [ "Q9N4U2", "WBGene00000647", "Q9N4U2", "WBGene00000647", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "Q21182", "WBGene00194737", "A0A0K3ARD1", "WBGene00194737" ] }, "reaction_10534197": { "compartment": "compartment_984", "id": "reaction_10534197", "reactome": "R-CEL-1454757", "name": "Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10534088" ], "products": [], "modifiers": [ [ "species_10534194", "catalyst" ] ], "additional_components": [ "Q9N4U2", "WBGene00000647", "O76368", "WBGene00000674", "Q09457", "WBGene00000251", "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "Q21182", "WBGene00194737" ] }, "reaction_10534266": { "compartment": "compartment_984", "id": "reaction_10534266", "reactome": "R-CEL-1454822", "name": "Collagen type I degradation by MMP1,2,8,13, PRSS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509625" ], "products": [ "species_10533300" ], "modifiers": [ [ "species_10534263", "catalyst" ] ], "additional_components": [ "Q9N4U2", "WBGene00000647", "Q9N4U2", "WBGene00000647", "Q21182", "WBGene00194737", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737" ] }, "reaction_10534362": { "compartment": "compartment_984", "id": "reaction_10534362", "reactome": "R-CEL-1474197", "name": "Collagen type II degradation by MMP1,3,8,13,PRSS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10517286" ], "products": [ "species_10533498" ], "modifiers": [ [ "species_10534359", "catalyst" ] ], "additional_components": [ "O76368", "WBGene00000674", "Q09457", "WBGene00000251", "Q9N4U2", "WBGene00000647", "Q09457", "WBGene00000251", "Q9N4U2", "WBGene00000647", "O76368", "WBGene00000674", "Q21182", "WBGene00194737", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737" ] }, "reaction_10543197": { "compartment": "compartment_876", "id": "reaction_10543197", "reactome": "R-CEL-2167942", "name": "Collagen type XIII ectodomain shedding", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10542932" ], "products": [ "species_10543195", "species_10543121" ], "modifiers": [], "additional_components": [ "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689", "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689", "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689" ] }, "reaction_10548284": { "compartment": "compartment_876", "id": "reaction_10548284", "reactome": "R-CEL-3791155", "name": "Laminin-322 degradation by MMP14", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10517354" ], "products": [ "species_10548282" ], "modifiers": [ [ "species_10534376", "catalyst" ] ], "additional_components": [ "O44565", "WBGene00002247", "Q18823", "WBGene00016913", "Q19981", "WBGene00006432", "G5EG68", "WBGene00018304", "Q06561", "WBGene00006787", "G5ECE3", "WBGene00002248", "Q21313", "WBGene00001328", "G5ECE3", "WBGene00002248", "Q21313", "WBGene00001328", "O44565", "WBGene00002247", "G5EG68", "WBGene00018304", "Q06561", "WBGene00006787", "Q18823", "WBGene00016913", "Q19981", "WBGene00006432", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "Q21182", "WBGene00194737", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283" ] }, "reaction_10568621": { "compartment": "compartment_984", "id": "reaction_10568621", "reactome": "R-CEL-8940554", "name": "MMP2 cleaves OPTC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10568612" ], "products": [ "species_10568618", "species_10568616", "species_10568614" ], "modifiers": [ [ "species_10534150", "catalyst" ] ], "additional_components": [ "WBGene00019351", "WBGene00019351", "WBGene00019351", "WBGene00019351", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "Q21182", "WBGene00194737", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646" ] }, "reaction_10511937": { "compartment": "compartment_7660", "id": "reaction_10511937", "reactome": "R-CEL-176318", "name": "Loading of claspin onto DNA during replication origin firing", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502234", "species_10511927" ], "products": [ "species_10511929" ], "modifiers": [], "additional_components": [ "Q7JMR0", "WBGene00009372", "O01493", "WBGene00016421", "Q9XX16", "WBGene00012651", "Q23249", "WBGene00013857", "Q9XX17", "WBGene00012650", "Q21037", "WBGene00003882", "P91155", "WBGene00000382", "O16297", "WBGene00003159", "Q95XQ8", "WBGene00003156", "Q9XXI9", "WBGene00003154", "Q21902", "WBGene00003157", "P34647", "WBGene00003158", "Q9XVR7", "WBGene00003155", "Q9U2C2", "WBGene00012935", "O61847", "WBGene00019362", "WBGene00009127", "O17838", "WBGene00009127", "Q7JMR0", "WBGene00009372", "O01493", "WBGene00016421", "Q9XX16", "WBGene00012651", "Q23249", "WBGene00013857", "Q9XX17", "WBGene00012650", "Q21037", "WBGene00003882", "P91155", "WBGene00000382", "O16297", "WBGene00003159", "Q95XQ8", "WBGene00003156", "Q9XXI9", "WBGene00003154", "Q21902", "WBGene00003157", "P34647", "WBGene00003158", "Q9XVR7", "WBGene00003155", "Q9U2C2", "WBGene00012935", "O61847", "WBGene00019362" ] }, "reaction_10511922": { "compartment": "compartment_7660", "id": "reaction_10511922", "reactome": "R-CEL-176264", "name": "Recruitment of the Rad9-Hus1-Rad1 complex to DNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10511917", "species_10511913" ], "products": [ "species_10511919" ], "modifiers": [ [ "species_10511917", "catalyst" ] ], "additional_components": [ "P53016", "WBGene00004340", "G5EGG2", "WBGene00001998", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "Q95Y97", "WBGene00019767", "G5EFI9", "WBGene00002042", "G5EC44", "WBGene00003417", "Q95Q27", "WBGene00001997", "G5EFI9", "WBGene00002042", "G5EC44", "WBGene00003417", "Q95Q27", "WBGene00001997", "P53016", "WBGene00004340", "G5EGG2", "WBGene00001998", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "Q95Y97", "WBGene00019767", "P53016", "WBGene00004340", "G5EGG2", "WBGene00001998", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "Q95Y97", "WBGene00019767" ] }, "reaction_10502791": { "compartment": "compartment_7660", "id": "reaction_10502791", "reactome": "R-CEL-69604", "name": "Phosphorylation of Cdc25A at Ser-123 by Chk1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10502759" ], "products": [ "species_113582", "species_10502781" ], "modifiers": [ [ "species_10502788", "catalyst" ] ], "additional_components": [ "WBGene00000389", "WBGene00000389", "WBGene00000498" ] }, "reaction_10507017": { "compartment": "compartment_7660", "id": "reaction_10507017", "reactome": "R-CEL-75010", "name": "Phosphorylation of Cdc25C at Ser 216 by Chk1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10507012" ], "products": [ "species_113582", "species_10507015" ], "modifiers": [ [ "species_10502788", "catalyst" ] ], "additional_components": [ "WBGene00000389", "WBGene00000389", "WBGene00000498" ] }, "reaction_10542996": { "compartment": "compartment_12045", "id": "reaction_10542996", "reactome": "R-CEL-2161890", "name": "Arachidonic acid is epoxidated to 5,6-EET by CYP(4)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29368", "species_29768", "species_29364" ], "products": [ "species_29356", "species_29366", "species_2142739" ], "modifiers": [ [ "species_10507902", "catalyst" ] ], "additional_components": [ "O45659", "WBGene00010589", "O61204", "WBGene00015045", "O61935", "WBGene00020386", "O62377", "WBGene00011699", "O62378", "WBGene00011698", "P90771", "WBGene00007913", "Q20315", "WBGene00018333", "A0A0M7RF98", "WBGene00018264", "Q27465", "WBGene00015135", "G5ECD0", "WBGene00007362", "Q27470", "WBGene00015709", "G5EE22", "WBGene00012448", "Q27471", "WBGene00016092", "H2KY69", "WBGene00015044", "Q27482", "WBGene00016768", "H2KYS3", "WBGene00000905", "Q27499", "WBGene00018334", "O02627", "WBGene00015399", "Q965T7", "WBGene00021710", "O02628", "WBGene00015400", "Q9N4Q4", "WBGene00021168", "O02641", "WBGene00019967", "Q9N5I1", "WBGene00019565", "O16220", "WBGene00016786", "O16362", "WBGene00018413", "O16482", "WBGene00016860", "O16670", "WBGene00018262", "O16671", "WBGene00018261", "O16673", "WBGene00018260", "O44649", "WBGene00019473", "O44650", "WBGene00019472", "O44651", "WBGene00019471", "O44652", "WBGene00019470", "O44655", "WBGene00015040", "O44656", "WBGene00015041", "O44657", "WBGene00015042", "O44658", "WBGene00015043", "O44704", "WBGene00016686", "O44706", "WBGene00016697", "O45364", "WBGene00008829" ] }, "reaction_10542998": { "compartment": "compartment_12045", "id": "reaction_10542998", "reactome": "R-CEL-2161899", "name": "Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29368", "species_29768", "species_29364" ], "products": [ "species_29356", "species_2161753", "species_29366" ], "modifiers": [ [ "species_10507902", "catalyst" ] ], "additional_components": [ "CHEBI:34130", "CHEBI:34490", "CHEBI:34157", "O45659", "WBGene00010589", "O61204", "WBGene00015045", "O61935", "WBGene00020386", "O62377", "WBGene00011699", "O62378", "WBGene00011698", "P90771", "WBGene00007913", "Q20315", "WBGene00018333", "A0A0M7RF98", "WBGene00018264", "Q27465", "WBGene00015135", "G5ECD0", "WBGene00007362", "Q27470", "WBGene00015709", "G5EE22", "WBGene00012448", "Q27471", "WBGene00016092", "H2KY69", "WBGene00015044", "Q27482", "WBGene00016768", "H2KYS3", "WBGene00000905", "Q27499", "WBGene00018334", "O02627", "WBGene00015399", "Q965T7", "WBGene00021710", "O02628", "WBGene00015400", "Q9N4Q4", "WBGene00021168", "O02641", "WBGene00019967", "Q9N5I1", "WBGene00019565", "O16220", "WBGene00016786", "O16362", "WBGene00018413", "O16482", "WBGene00016860", "O16670", "WBGene00018262", "O16671", "WBGene00018261", "O16673", "WBGene00018260", "O44649", "WBGene00019473", "O44650", "WBGene00019472", "O44651", "WBGene00019471", "O44652", "WBGene00019470", "O44655", "WBGene00015040", "O44656", "WBGene00015041", "O44657", "WBGene00015042", "O44658", "WBGene00015043", "O44704", "WBGene00016686", "O44706", "WBGene00016697", "O45364", "WBGene00008829" ] }, "reaction_10519552": { "compartment": "compartment_70101", "id": "reaction_10519552", "reactome": "R-CEL-377644", "name": "Release of CSK from SRC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10519544" ], "products": [ "species_10518223", "species_10519550" ], "modifiers": [], "additional_components": [ "species_74016", "species_266099", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "G5ECJ6", "WBGene00000812", "P34446", "WBGene00003929", "G5EGK1", "WBGene00006771", "species_179856", "Q18246", "WBGene00004307", "species_29438", "P34400", "WBGene00003243", "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769", "WBGene00000812", "species_74016", "species_266099", "G5EGK1", "WBGene00006771", "species_179856", "Q18246", "WBGene00004307", "species_29438", "P34400", "WBGene00003243", "P34446", "WBGene00003929", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769" ] }, "reaction_10518244": { "compartment": "compartment_70101", "id": "reaction_10518244", "reactome": "R-CEL-354087", "name": "Recruitment of GRB2 to p-PTK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10506871", "species_10518240" ], "products": [ "species_10518242" ], "modifiers": [], "additional_components": [ "WBGene00004774", "species_74016", "species_266099", "G5EGK1", "WBGene00006771", "species_179856", "Q18246", "WBGene00004307", "species_29438", "P34400", "WBGene00003243", "P34446", "WBGene00003929", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769", "Q95YD4", "WBGene00002213", "species_74016", "species_266099", "G5EGK1", "WBGene00006771", "species_179856", "Q18246", "WBGene00004307", "species_29438", "P34400", "WBGene00003243", "P34446", "WBGene00003929", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769", "Q95YD4", "WBGene00002213", "P29355", "WBGene00004774" ] }, "reaction_10518263": { "compartment": "compartment_70101", "id": "reaction_10518263", "reactome": "R-CEL-354165", "name": "Interaction of SOS with GRB2 bound to FADK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10506876", "species_10518242" ], "products": [ "species_10518261" ], "modifiers": [], "additional_components": [ "WBGene00004947", "species_74016", "species_266099", "G5EGK1", "WBGene00006771", "species_179856", "Q18246", "WBGene00004307", "species_29438", "P34400", "WBGene00003243", "P34446", "WBGene00003929", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769", "Q95YD4", "WBGene00002213", "P29355", "WBGene00004774", "species_74016", "species_266099", "G5EGK1", "WBGene00006771", "species_179856", "Q18246", "WBGene00004307", "species_29438", "P34400", "WBGene00003243", "P34446", "WBGene00003929", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769", "Q95YD4", "WBGene00002213", "P29355", "WBGene00004774", "Q9N5D3", "WBGene00004947" ] }, "reaction_10518210": { "compartment": "compartment_70101", "id": "reaction_10518210", "reactome": "R-CEL-354073", "name": "Autophosphorylation of PTK2 at Y397", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10518200" ], "products": [ "species_10518207", "species_29370" ], "modifiers": [ [ "species_10518200", "catalyst" ] ], "additional_components": [ "species_74016", "species_266099", "G5EGK1", "WBGene00006771", "species_179856", "Q18246", "WBGene00004307", "species_29438", "P34400", "WBGene00003243", "P34446", "WBGene00003929", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769", "Q95YD4", "WBGene00002213", "species_74016", "species_266099", "G5EGK1", "WBGene00006771", "species_179856", "Q18246", "WBGene00004307", "species_29438", "P34400", "WBGene00003243", "P34446", "WBGene00003929", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769", "Q95YD4", "WBGene00002213", "species_74016", "species_266099", "G5EGK1", "WBGene00006771", "species_179856", "Q18246", "WBGene00004307", "species_29438", "P34400", "WBGene00003243", "P34446", "WBGene00003929", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769", "Q95YD4", "WBGene00002213" ] }, "reaction_10518277": { "compartment": "compartment_70101", "id": "reaction_10518277", "reactome": "R-CEL-354173", "name": "Activation of Rap1 by cytosolic GEFs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10518265" ], "products": [ "species_29420", "species_10518164" ], "modifiers": [ [ "species_10518274", "catalyst" ] ], "additional_components": [ "Q18246", "WBGene00004307", "species_29420", "Q18246", "WBGene00004307", "species_29438", "species_74016", "species_114519", "Q19770", "WBGene00009100" ] }, "reaction_10518246": { "compartment": "compartment_70101", "id": "reaction_10518246", "reactome": "R-CEL-354097", "name": "Activation of Talin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10518171", "species_10518194" ], "products": [ "species_10518196" ], "modifiers": [], "additional_components": [ "species_179856", "Q18246", "WBGene00004307", "species_29438", "P34400", "WBGene00003243", "WBGene00006771", "G5EGK1", "WBGene00006771", "species_179856", "Q18246", "WBGene00004307", "species_29438", "P34400", "WBGene00003243" ] }, "reaction_10523400": { "compartment": "compartment_70101", "id": "reaction_10523400", "reactome": "R-CEL-429415", "name": "SYK binds to integrin alphaIIb beta3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10516474", "species_10518198" ], "products": [ "species_10523398" ], "modifiers": [], "additional_components": [ "WBGene00016416", "species_74016", "species_266099", "G5EGK1", "WBGene00006771", "species_179856", "Q18246", "WBGene00004307", "species_29438", "P34400", "WBGene00003243", "P34446", "WBGene00003929", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769", "species_74016", "species_266099", "G5EGK1", "WBGene00006771", "species_179856", "Q18246", "WBGene00004307", "species_29438", "P34400", "WBGene00003243", "P34446", "WBGene00003929", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769", "Q18462", "WBGene00016416" ] }, "reaction_10518255": { "compartment": "compartment_70101", "id": "reaction_10518255", "reactome": "R-CEL-354124", "name": "Phosphorylation of pPTK2 by SRC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10518207", "species_113592" ], "products": [ "species_29370", "species_10518240" ], "modifiers": [ [ "species_10518207", "catalyst" ] ], "additional_components": [ "species_74016", "species_266099", "G5EGK1", "WBGene00006771", "species_179856", "Q18246", "WBGene00004307", "species_29438", "P34400", "WBGene00003243", "P34446", "WBGene00003929", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769", "Q95YD4", "WBGene00002213", "species_74016", "species_266099", "G5EGK1", "WBGene00006771", "species_179856", "Q18246", "WBGene00004307", "species_29438", "P34400", "WBGene00003243", "P34446", "WBGene00003929", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769", "Q95YD4", "WBGene00002213", "species_74016", "species_266099", "G5EGK1", "WBGene00006771", "species_179856", "Q18246", "WBGene00004307", "species_29438", "P34400", "WBGene00003243", "P34446", "WBGene00003929", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769", "Q95YD4", "WBGene00002213" ] }, "reaction_10523408": { "compartment": "compartment_70101", "id": "reaction_10523408", "reactome": "R-CEL-429441", "name": "SYK activation by SRC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10523398" ], "products": [ "species_10523405", "species_29370" ], "modifiers": [ [ "species_10523398", "catalyst" ] ], "additional_components": [ "species_74016", "species_266099", "G5EGK1", "WBGene00006771", "species_179856", "Q18246", "WBGene00004307", "species_29438", "P34400", "WBGene00003243", "P34446", "WBGene00003929", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769", "Q18462", "WBGene00016416", "species_74016", "species_266099", "G5EGK1", "WBGene00006771", "species_179856", "Q18246", "WBGene00004307", "species_29438", "P34400", "WBGene00003243", "P34446", "WBGene00003929", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769", "Q18462", "WBGene00016416", "species_74016", "species_266099", "G5EGK1", "WBGene00006771", "species_179856", "Q18246", "WBGene00004307", "species_29438", "P34400", "WBGene00003243", "P34446", "WBGene00003929", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769", "Q18462", "WBGene00016416" ] }, "reaction_10529458": { "compartment": "compartment_70101", "id": "reaction_10529458", "reactome": "R-CEL-939265", "name": "Activation of Rap1 by membrane-associated GEFs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10518265" ], "products": [ "species_29420", "species_10518164" ], "modifiers": [ [ "species_10520078", "catalyst" ] ], "additional_components": [ "Q18246", "WBGene00004307", "species_29420", "Q18246", "WBGene00004307", "species_29438", "WBGene00004255" ] }, "reaction_10518259": { "compartment": "compartment_984", "id": "reaction_10518259", "reactome": "R-CEL-354149", "name": "Interaction of integrin alphaIIb beta3 with Fibrinogen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10515311", "species_10518229", "species_377604" ], "products": [ "species_10518257" ], "modifiers": [], "additional_components": [ "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "G5ECJ6", "WBGene00000812", "P34446", "WBGene00003929", "G5EGK1", "WBGene00006771", "species_179856", "Q18246", "WBGene00004307", "species_29438", "P34400", "WBGene00003243", "species_74016", "species_266099", "species_74016", "species_266099", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "G5ECJ6", "WBGene00000812", "P34446", "WBGene00003929", "G5EGK1", "WBGene00006771", "species_179856", "Q18246", "WBGene00004307", "species_29438", "P34400", "WBGene00003243", "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769" ] }, "reaction_10519542": { "compartment": "compartment_70101", "id": "reaction_10519542", "reactome": "R-CEL-377640", "name": "Autophosphorylation of SRC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10519539" ], "products": [ "species_29370", "species_10518198" ], "modifiers": [ [ "species_10513079", "catalyst" ] ], "additional_components": [ "species_74016", "species_266099", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "P34446", "WBGene00003929", "G5EGK1", "WBGene00006771", "species_179856", "Q18246", "WBGene00004307", "species_29438", "P34400", "WBGene00003243", "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769", "species_74016", "species_266099", "G5EGK1", "WBGene00006771", "species_179856", "Q18246", "WBGene00004307", "species_29438", "P34400", "WBGene00003243", "P34446", "WBGene00003929", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635" ] }, "reaction_10518231": { "compartment": "compartment_876", "id": "reaction_10518231", "reactome": "R-CEL-354077", "name": "Integrin alphaIIb beta3 activation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10518196", "species_10518227" ], "products": [ "species_10518229" ], "modifiers": [], "additional_components": [ "G5EGK1", "WBGene00006771", "species_179856", "Q18246", "WBGene00004307", "species_29438", "P34400", "WBGene00003243", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "G5ECJ6", "WBGene00000812", "P34446", "WBGene00003929", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "G5ECJ6", "WBGene00000812", "P34446", "WBGene00003929", "G5EGK1", "WBGene00006771", "species_179856", "Q18246", "WBGene00004307", "species_29438", "P34400", "WBGene00003243" ] }, "reaction_10519546": { "compartment": "compartment_876", "id": "reaction_10519546", "reactome": "R-CEL-377641", "name": "Clustering of Integrin alphaIIb beta3 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10518227", "species_10518257" ], "products": [ "species_10519544" ], "modifiers": [], "additional_components": [ "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "G5ECJ6", "WBGene00000812", "P34446", "WBGene00003929", "species_74016", "species_266099", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "G5ECJ6", "WBGene00000812", "P34446", "WBGene00003929", "G5EGK1", "WBGene00006771", "species_179856", "Q18246", "WBGene00004307", "species_29438", "P34400", "WBGene00003243", "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769", "species_74016", "species_266099", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "G5ECJ6", "WBGene00000812", "P34446", "WBGene00003929", "G5EGK1", "WBGene00006771", "species_179856", "Q18246", "WBGene00004307", "species_29438", "P34400", "WBGene00003243", "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769" ] }, "reaction_10518202": { "compartment": "compartment_70101", "id": "reaction_10518202", "reactome": "R-CEL-354066", "name": "Translocation of PTK2 to Focal complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10514906", "species_10518198" ], "products": [ "species_10518200" ], "modifiers": [], "additional_components": [ "WBGene00002213", "species_74016", "species_266099", "G5EGK1", "WBGene00006771", "species_179856", "Q18246", "WBGene00004307", "species_29438", "P34400", "WBGene00003243", "P34446", "WBGene00003929", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769", "species_74016", "species_266099", "G5EGK1", "WBGene00006771", "species_179856", "Q18246", "WBGene00004307", "species_29438", "P34400", "WBGene00003243", "P34446", "WBGene00003929", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769", "Q95YD4", "WBGene00002213" ] }, "reaction_10524570": { "compartment": "compartment_876", "id": "reaction_10524570", "reactome": "R-CEL-443905", "name": "SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10524564" ], "products": [ "species_10524568" ], "modifiers": [], "additional_components": [ "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "G5ECJ6", "WBGene00000812", "P34446", "WBGene00003929", "G5EGK1", "WBGene00006771", "species_179856", "Q18246", "WBGene00004307", "species_29438", "P34400", "WBGene00003243", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "G5ECJ6", "WBGene00000812", "P34446", "WBGene00003929", "G5EGK1", "WBGene00006771", "species_179856", "Q18246", "WBGene00004307", "species_29438", "P34400", "WBGene00003243" ] }, "reaction_10518173": { "compartment": "compartment_70101", "id": "reaction_10518173", "reactome": "R-CEL-354060", "name": "Translocation of RIAM to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10518169", "species_10518164", "species_179856" ], "products": [ "species_10518171" ], "modifiers": [], "additional_components": [ "WBGene00003243", "Q18246", "WBGene00004307", "species_29438", "species_179856", "Q18246", "WBGene00004307", "species_29438", "P34400", "WBGene00003243" ] }, "reaction_10503824": { "compartment": "compartment_70101", "id": "reaction_10503824", "reactome": "R-CEL-71188", "name": "TDO tetramer dioxygenates L-Trp to NFK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29500", "species_29368" ], "products": [ "species_33179" ], "modifiers": [ [ "species_10503821", "catalyst" ] ], "additional_components": [ "species_71185", "Q09474", "WBGene00016201" ] }, "reaction_10503843": { "compartment": "compartment_70101", "id": "reaction_10503843", "reactome": "R-CEL-71217", "name": "3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_34351", "species_29356" ], "products": [ "species_29432", "species_30487" ], "modifiers": [ [ "species_10503840", "catalyst" ] ], "additional_components": [ "Q18026", "WBGene00015802" ] }, "reaction_10503832": { "compartment": "compartment_70101", "id": "reaction_10503832", "reactome": "R-CEL-71200", "name": "kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29368", "species_29364", "species_29970" ], "products": [ "species_34351", "species_29356", "species_29366" ], "modifiers": [ [ "species_10503829", "catalyst" ] ], "additional_components": [ "WBGene00011089" ] }, "reaction_10528412": { "compartment": "compartment_70101", "id": "reaction_10528412", "reactome": "R-CEL-893596", "name": "PXLP-KYAT1 dimer transaminates L-KYN to AP-DOBu", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29398", "species_29970" ], "products": [ "species_29432", "species_893615" ], "modifiers": [ [ "species_10528406", "catalyst" ], [ "species_29502", "inhibitor" ], [ "species_8939576", "inhibitor" ] ], "additional_components": [ "Q9XX97", "WBGene00009232", "Q8MP09", "WBGene00010984", "CHEBI:55528", "CHEBI:43580" ] }, "reaction_10503853": { "compartment": "compartment_70101", "id": "reaction_10503853", "reactome": "R-CEL-71218", "name": "3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_30487" ], "products": [ "species_36027" ], "modifiers": [ [ "species_10503850", "catalyst" ] ], "additional_components": [ "Q19341", "WBGene00010595", "species_113531" ] }, "reaction_10566750": { "compartment": "compartment_876", "id": "reaction_10566750", "reactome": "R-CEL-8870352", "name": "SLC36A4 transports L-Trp from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352006" ], "products": [ "species_29500" ], "modifiers": [ [ "species_10566747", "catalyst" ] ], "additional_components": [ "O45936", "WBGene00012804", "O62286", "WBGene00010421", "P34479", "WBGene00010307", "Q18595", "WBGene00016628", "Q9XX44", "WBGene00012629", "G4SQY7", "WBGene00020837" ] }, "reaction_10542434": { "compartment": "compartment_17951", "id": "reaction_10542434", "reactome": "R-CEL-2066778", "name": "Hydration of delta2-tetracosaheptaenoyl-CoA to 3-hydroxy tetracosahexaenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_141343", "species_2066767" ], "products": [ "species_2066766" ], "modifiers": [ [ "species_10513270", "catalyst" ] ], "additional_components": [ "Q19058", "WBGene00017123" ] }, "reaction_10542291": { "compartment": "compartment_12045", "id": "reaction_10542291", "reactome": "R-CEL-2046084", "name": "Desaturation of alpha-linoleoyl-CoA to Stearidonoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_194697", "species_2046062" ], "products": [ "species_194653", "species_113519", "species_2046052" ], "modifiers": [ [ "species_10542288", "catalyst" ] ], "additional_components": [ "WBGene00001395" ] }, "reaction_10542308": { "compartment": "compartment_17957", "id": "reaction_10542308", "reactome": "R-CEL-2046089", "name": "Desaturation of eicosatetraenoyl-CoA to eicosapentaenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_2046051", "species_194697" ], "products": [ "species_194653", "species_113519", "species_2046059" ], "modifiers": [ [ "species_10542305", "catalyst" ] ], "additional_components": [ "G5EG11", "WBGene00001396", "Q23221", "WBGene00001395" ] }, "reaction_10542436": { "compartment": "compartment_17951", "id": "reaction_10542436", "reactome": "R-CEL-2066779", "name": "Conversion of DHA-CoA to docosahexaenoic acid (DHA)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_141343", "species_2066765" ], "products": [ "species_193514", "species_2066763" ], "modifiers": [ [ "species_10513389", "catalyst" ] ], "additional_components": [ "WBGene00015887" ] }, "reaction_10542294": { "compartment": "compartment_17957", "id": "reaction_10542294", "reactome": "R-CEL-2046087", "name": "Translocation of tetracosahexaenoyl-CoA to peroxisomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2046054", "species_211579" ], "products": [ "species_426639", "species_211606", "species_2046047" ], "modifiers": [ [ "species_10520379", "catalyst" ] ], "additional_components": [ "WBGene00004061" ] }, "reaction_10542438": { "compartment": "compartment_17951", "id": "reaction_10542438", "reactome": "R-CEL-2066780", "name": "Dehydrogenation of 3-hydroxy tetracosahexaenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2066766" ], "products": [ "species_2066762" ], "modifiers": [ [ "species_10513270", "catalyst" ] ], "additional_components": [ "Q19058", "WBGene00017123" ] }, "reaction_10542296": { "compartment": "compartment_17957", "id": "reaction_10542296", "reactome": "R-CEL-2046088", "name": "Elongation of stearidonoyl-CoA to eicosatetraenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2046066", "species_2046052", "species_113601" ], "products": [ "species_113519", "species_113564", "species_2046051", "species_162743", "species_159751" ], "modifiers": [ [ "species_10527261", "catalyst" ] ], "additional_components": [ "WBGene00001241" ] }, "reaction_10542440": { "compartment": "compartment_17951", "id": "reaction_10542440", "reactome": "R-CEL-2066787", "name": "Oxidation of tetracosapentaenoyl-CoA to delta2-tetracosaheptaenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113535", "species_2046047" ], "products": [ "species_113575", "species_2066767" ], "modifiers": [ [ "species_10520766", "catalyst" ] ], "additional_components": [ "species_113596", "O62138", "WBGene00008566" ] }, "reaction_10567994": { "compartment": "compartment_70101", "id": "reaction_10567994", "reactome": "R-CEL-8932355", "name": "26S proteasome degrades Ub-NFE2L2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10567992" ], "products": [ "species_10502375" ], "modifiers": [ [ "species_10502572", "catalyst" ] ], "additional_components": [ "P34707", "WBGene00004804", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "P91477", "WBGene00003950", "Q95PZ7", "WBGene00013435", "Q18115", "WBGene00004459", "O62102", "WBGene00003948", "O17071", "WBGene00004504", "Q10920", "WBGene00016623", "P34286", "WBGene00003952", "Q9XTT9", "WBGene00004506", "Q23449", "WBGene00004468", "Q95005", "WBGene00003925", "P46502", "WBGene00004503", "O61792", "WBGene00004464", "O17586", "WBGene00003922", "O76371", "WBGene00004505", "Q20585", "WBGene00004463", "Q95008", "WBGene00003926", "Q18787", "WBGene00004501", "Q20058", "WBGene00009445", "Q9N599", "WBGene00003924", "O16368", "WBGene00004502", "O61742", "WBGene00004466", "Q09583", "WBGene00003928", "Q966I8", "WBGene00003947", "Q04908", "WBGene00004460", "Q9XUV0", "WBGene00003951", "Q27488", "WBGene00003923", "Q9GZH5", "WBGene00004458", "O44156", "WBGene00003927", "Q22253", "WBGene00004465", "O76577", "WBGene00004467", "P90868", "WBGene00003953", "Q19324", "WBGene00004461", "Q17971", "WBGene00007588", "Q23237", "WBGene00003949", "Q20938", "WBGene00004462" ] }, "reaction_10573338": { "compartment": "compartment_70101", "id": "reaction_10573338", "reactome": "R-CEL-9712274", "name": "NFE2L2 inducers bind to KEAP1:CUL3:RBX1:NFE2L2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10567990", "species_9714134" ], "products": [ "species_10573336" ], "modifiers": [], "additional_components": [ "P34707", "WBGene00004804", "Q23457", "WBGene00004320", "Q17391", "WBGene00000838", "P34707", "WBGene00004804", "Q23457", "WBGene00004320", "Q17391", "WBGene00000838" ] }, "reaction_10567982": { "compartment": "compartment_70101", "id": "reaction_10567982", "reactome": "R-CEL-8932309", "name": "NFE2L2 translocates from cytosol to nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10567974" ], "products": [ "species_10567980" ], "modifiers": [], "additional_components": [] }, "reaction_10553087": { "compartment": "compartment_876", "id": "reaction_10553087", "reactome": "R-CEL-5621363", "name": "SYK phosphorylates PLCG2 in p-6Y-SYK:p-Y65,Y76-FCER1G:PLCG2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10553084", "species_113592" ], "products": [ "species_10553082", "species_29370" ], "modifiers": [ [ "species_10553084", "catalyst" ] ], "additional_components": [ "Q22070", "WBGene00004038", "Q18462", "WBGene00016416", "Q22070", "WBGene00004038", "Q18462", "WBGene00016416", "Q22070", "WBGene00004038", "Q18462", "WBGene00016416" ] }, "reaction_10565886": { "compartment": "compartment_876", "id": "reaction_10565886", "reactome": "R-CEL-8858500", "name": "CLEC10A binds Tn-MUC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10565882", "species_10565876" ], "products": [ "species_10565884" ], "modifiers": [], "additional_components": [ "Q9U2D6", "WBGene00012901", "P34501", "WBGene00010540", "Q9N4W4", "WBGene00021602", "Q9N4W5", "WBGene00021603", "O18076", "WBGene00011668", "O44871", "WBGene00019914", "P91214", "WBGene00017199", "Q21146", "WBGene00019328", "Q9N4W4", "WBGene00021602", "Q9N4W5", "WBGene00021603", "O18076", "WBGene00011668", "O44871", "WBGene00019914", "P91214", "WBGene00017199", "Q21146", "WBGene00019328", "Q9U2D6", "WBGene00012901", "P34501", "WBGene00010540" ] }, "reaction_10531875": { "compartment": "compartment_20699", "id": "reaction_10531875", "reactome": "R-CEL-1028788", "name": "FUT8 transfers fucosyl group from GDP-Fuc to GlcNAc of NGP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_975910", "species_205683" ], "products": [ "species_205689", "species_1028779" ], "modifiers": [ [ "species_10531872", "catalyst" ] ], "additional_components": [ "WBGene00001508" ] }, "reaction_10530580": { "compartment": "compartment_20699", "id": "reaction_10530580", "reactome": "R-CEL-975814", "name": "Trimming of mannoses on the alpha1,6 arm by MAN2A1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_964837" ], "products": [ "species_964752", "species_975819" ], "modifiers": [ [ "species_10530577", "catalyst" ] ], "additional_components": [ "species_216785", "Q2PJ74", "WBGene00010284" ] }, "reaction_10557159": { "compartment": "compartment_17963", "id": "reaction_10557159", "reactome": "R-CEL-5693925", "name": "FUT3 transfers L-fucose to Gal1,3GlcNAc", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5693930", "species_205683" ], "products": [ "species_5693933", "species_205689" ], "modifiers": [ [ "species_10557156", "catalyst" ] ], "additional_components": [ "WBGene00016163" ] }, "reaction_10530588": { "compartment": "compartment_20699", "id": "reaction_10530588", "reactome": "R-CEL-975829", "name": "Addition of a GlcNAc on the alpha 1,4 branch by MGAT2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_914003", "species_975819" ], "products": [ "species_205687", "species_975822" ], "modifiers": [ [ "species_10530585", "catalyst" ] ], "additional_components": [ "WBGene00001645" ] }, "reaction_10557151": { "compartment": "compartment_161320", "id": "reaction_10557151", "reactome": "R-CEL-5693807", "name": "FUCA1 hydrolyses NGP:1,6-GlcNAc", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_6784247" ], "products": [ "species_6784248", "species_6784249" ], "modifiers": [ [ "species_10557148", "catalyst" ] ], "additional_components": [ "P49713", "WBGene00012225" ] }, "reaction_10502093": { "compartment": "compartment_7660", "id": "reaction_10502093", "reactome": "R-CEL-68637", "name": "CDC6 protein is synthesized under the control of E2F transcription factors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [], "products": [ "species_10502084" ], "modifiers": [ [ "species_10502089", "catalyst" ] ], "additional_components": [ "WBGene00000382", "WBGene00001162" ] }, "reaction_10508790": { "compartment": "compartment_7660", "id": "reaction_10508790", "reactome": "R-CEL-110349", "name": "Displacement of UNG glycosylase by APEX1 at the AP site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508670", "species_10508786" ], "products": [ "species_10508664", "species_10508788" ], "modifiers": [], "additional_components": [ "Q9U221", "WBGene00013241", "WBGene00001372", "WBGene00013241", "G5EBR7", "WBGene00001372" ] }, "reaction_10508792": { "compartment": "compartment_7660", "id": "reaction_10508792", "reactome": "R-CEL-110352", "name": "Displacement of NTHL1 glycosylase by APEX1 at the AP site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508686", "species_10508786" ], "products": [ "species_10508788", "species_10508657" ], "modifiers": [], "additional_components": [ "P54137", "WBGene00011201", "WBGene00001372", "G5EBR7", "WBGene00001372", "WBGene00011201" ] }, "reaction_10529620": { "compartment": "compartment_20699", "id": "reaction_10529620", "reactome": "R-CEL-964825", "name": "Progressive trimming of alpha-1,2-linked mannose residues from Man8GlcNAc2 to produce Man5GlcNAc2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_964831" ], "products": [ "species_964752", "species_964740" ], "modifiers": [ [ "species_10529593", "catalyst" ] ], "additional_components": [ "CHEBI:60629", "CHEBI:60628", "CHEBI:60627", "P90787", "WBGene00008411", "Q18788", "WBGene00008258" ] }, "reaction_10529622": { "compartment": "compartment_20699", "id": "reaction_10529622", "reactome": "R-CEL-964830", "name": "Progressive trimming of alpha-1,2-linked mannose residues from Man7GlcNAc2 to produce Man5GlcNAc2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_964828" ], "products": [ "species_964752", "species_964740" ], "modifiers": [ [ "species_10529593", "catalyst" ] ], "additional_components": [ "P90787", "WBGene00008411", "Q18788", "WBGene00008258" ] }, "reaction_10529596": { "compartment": "compartment_20699", "id": "reaction_10529596", "reactome": "R-CEL-964737", "name": "Progressive trimming of alpha-1,2-linked mannose residues from Man9GlcNAc2 to produce Man5GlcNAc2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_915149" ], "products": [ "species_964752", "species_964740" ], "modifiers": [ [ "species_10529593", "catalyst" ] ], "additional_components": [ "P90787", "WBGene00008411", "Q18788", "WBGene00008258" ] }, "reaction_10568853": { "compartment": "compartment_70101", "id": "reaction_10568853", "reactome": "R-CEL-8948757", "name": "AKT phosphorylates MKRN1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10531086", "species_113592" ], "products": [ "species_29370", "species_10568851" ], "modifiers": [ [ "species_10513848", "catalyst" ] ], "additional_components": [ "WBGene00002278", "WBGene00002278", "Q9XTG7", "WBGene00000103", "G4S4W1", "WBGene00016980", "Q17941", "WBGene00000102" ] }, "reaction_10513917": { "compartment": "compartment_70101", "id": "reaction_10513917", "reactome": "R-CEL-198621", "name": "AKT phosphorylates caspase-9", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10509443" ], "products": [ "species_10513915", "species_29370" ], "modifiers": [ [ "species_10513848", "catalyst" ] ], "additional_components": [ "P42573", "WBGene00000417", "G5EBM1", "WBGene00000819", "G5EBM1", "WBGene00000819", "P42573", "WBGene00000417", "Q9XTG7", "WBGene00000103", "G4S4W1", "WBGene00016980", "Q17941", "WBGene00000102" ] }, "reaction_10523796": { "compartment": "compartment_876", "id": "reaction_10523796", "reactome": "R-CEL-432049", "name": "Aquaporin-9 passively transports glycerol into cell", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_192438" ], "products": [ "species_76116" ], "modifiers": [ [ "species_10523793", "catalyst" ] ], "additional_components": [ "Q7YWQ1", "WBGene00013272", "Q17571", "WBGene00000170", "Q7Z138", "WBGene00000176", "Q19949", "WBGene00000169", "Q9XW36", "WBGene00000171", "Q21473", "WBGene00000175" ] }, "reaction_10523803": { "compartment": "compartment_876", "id": "reaction_10523803", "reactome": "R-CEL-432074", "name": "Aquaporin-7 passively transports glycerol out of cell", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76116" ], "products": [ "species_192438" ], "modifiers": [ [ "species_10523800", "catalyst" ] ], "additional_components": [ "Q9XW36", "WBGene00000171" ] }, "reaction_10530450": { "compartment": "compartment_876", "id": "reaction_10530450", "reactome": "R-CEL-975389", "name": "GLRA:GLRB:Gly transports extracellular Cl- to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_188972" ], "products": [ "species_352022" ], "modifiers": [ [ "species_10530447", "catalyst" ] ], "additional_components": [ "species_159549", "G5EBR3", "WBGene00001591", "Q95QT7", "WBGene00001594", "G5ECH3", "WBGene00000233", "Q95Y52", "WBGene00022106", "G5EDN0", "WBGene00018880", "Q9GQ00", "WBGene00003386", "G5EEC1", "WBGene00013746", "Q9NA62", "WBGene00013517", "G5EEX8", "WBGene00009799", "Q9U358", "WBGene00012099", "G5EEZ3", "WBGene00001593", "X5LVB0", "WBGene00017399", "H2KYN9", "WBGene00020657", "O17041", "WBGene00020528", "P41849", "WBGene00020605", "P91985", "WBGene00008223", "Q10052", "WBGene00001588", "Q17328", "WBGene00001592", "Q18812", "WBGene00008280", "Q21005", "WBGene00010275", "Q21420", "WBGene00010741", "Q95Q97", "WBGene00000232" ] }, "reaction_10572690": { "compartment": "compartment_876", "id": "reaction_10572690", "reactome": "R-CEL-9648983", "name": "HTR3A pentamer:5HT transports Na+,K+,Ca2+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74126", "species_74112", "species_74113" ], "products": [ "species_29804", "species_83910", "species_74016" ], "modifiers": [ [ "species_10572687", "catalyst" ] ], "additional_components": [ "O76554", "WBGene00000955", "P54244", "WBGene00000951", "P54245", "WBGene00017580", "P54246", "WBGene00000044", "Q19351", "WBGene00017375", "Q22079", "WBGene00011354", "Q22080", "WBGene00011355", "Q22081", "WBGene00011356", "Q22083", "WBGene00011358", "Q22084", "WBGene00011360", "Q22085", "WBGene00011359", "Q6BEQ0", "WBGene00013338", "Q6F6K3", "WBGene00000056", "Q95Y94", "WBGene00020048", "Q9NAM5", "WBGene00013655", "V6CJ96", "WBGene00022247", "A0A3P6P985", "WBGene00000060", "B1Q281", "WBGene00000059", "G5ECT0", "WBGene00012857", "G5EG72", "WBGene00000057", "G5EG88", "WBGene00000062", "G5EGR1", "WBGene00000061", "H2KML8", "WBGene00013534", "O16426", "WBGene00020236", "O18228", "WBGene00013300", "O44452", "WBGene00015412", "O61519", "WBGene00017544", "O61520", "WBGene00017543", "species_380585" ] }, "reaction_10527788": { "compartment": "compartment_70101", "id": "reaction_10527788", "reactome": "R-CEL-629595", "name": "Activation of highly calcium permeable postsynaptic nicotinic acetylcholine receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74112" ], "products": [ "species_74016" ], "modifiers": [ [ "species_10527785", "catalyst" ] ], "additional_components": [ "A0A3P6P985", "WBGene00000060", "P48182", "WBGene00000042", "Q9N587", "WBGene00006797", "G5EDF1", "WBGene00000051", "Q93149", "WBGene00000043", "Q23022", "WBGene00006774", "O17274", "WBGene00020836", "Q93329", "WBGene00002975", "Q23355", "WBGene00000047", "P48181", "WBGene00006765", "Q9N4M3", "WBGene00000045", "Q27218", "WBGene00002974", "H2KZY7", "WBGene00022283", "B3WFZ2", "WBGene00000058", "species_372533" ] }, "reaction_10527790": { "compartment": "compartment_984", "id": "reaction_10527790", "reactome": "R-CEL-629596", "name": "Binding of acetylcholine to highly calcium permeable postsynaptic nicotinic acetylcholine receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10527783", "species_372533" ], "products": [ "species_10527785" ], "modifiers": [], "additional_components": [ "A0A3P6P985", "WBGene00000060", "P48182", "WBGene00000042", "Q9N587", "WBGene00006797", "G5EDF1", "WBGene00000051", "Q93149", "WBGene00000043", "Q23022", "WBGene00006774", "O17274", "WBGene00020836", "Q93329", "WBGene00002975", "Q23355", "WBGene00000047", "P48181", "WBGene00006765", "Q9N4M3", "WBGene00000045", "Q27218", "WBGene00002974", "H2KZY7", "WBGene00022283", "B3WFZ2", "WBGene00000058", "A0A3P6P985", "WBGene00000060", "P48182", "WBGene00000042", "Q9N587", "WBGene00006797", "G5EDF1", "WBGene00000051", "Q93149", "WBGene00000043", "Q23022", "WBGene00006774", "O17274", "WBGene00020836", "Q93329", "WBGene00002975", "Q23355", "WBGene00000047", "P48181", "WBGene00006765", "Q9N4M3", "WBGene00000045", "Q27218", "WBGene00002974", "H2KZY7", "WBGene00022283", "B3WFZ2", "WBGene00000058", "species_372533" ] }, "reaction_10527792": { "compartment": "compartment_984", "id": "reaction_10527792", "reactome": "R-CEL-629599", "name": "Binding of acetylcholine to highly calcium permeable acetylcholine receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_372533", "species_10527760" ], "products": [ "species_10527762" ], "modifiers": [], "additional_components": [ "O17274", "WBGene00020836", "Q9N4M3", "WBGene00000045", "P48181", "WBGene00006765", "Q9N587", "WBGene00006797", "P48182", "WBGene00000042", "Q23022", "WBGene00006774", "Q23355", "WBGene00000047", "Q27218", "WBGene00002974", "Q93149", "WBGene00000043", "G5EDF1", "WBGene00000051", "Q93329", "WBGene00002975", "H2KZY7", "WBGene00022283", "O17274", "WBGene00020836", "Q9N4M3", "WBGene00000045", "P48181", "WBGene00006765", "Q9N587", "WBGene00006797", "P48182", "WBGene00000042", "Q23022", "WBGene00006774", "Q23355", "WBGene00000047", "Q27218", "WBGene00002974", "Q93149", "WBGene00000043", "G5EDF1", "WBGene00000051", "Q93329", "WBGene00002975", "H2KZY7", "WBGene00022283", "species_372533" ] }, "reaction_10527765": { "compartment": "compartment_876", "id": "reaction_10527765", "reactome": "R-CEL-622326", "name": "Activation of highly calcium permeable nicotinic acetylcholine receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74112" ], "products": [ "species_74016" ], "modifiers": [ [ "species_10527762", "catalyst" ] ], "additional_components": [ "O17274", "WBGene00020836", "Q9N4M3", "WBGene00000045", "P48181", "WBGene00006765", "Q9N587", "WBGene00006797", "P48182", "WBGene00000042", "Q23022", "WBGene00006774", "Q23355", "WBGene00000047", "Q27218", "WBGene00002974", "Q93149", "WBGene00000043", "G5EDF1", "WBGene00000051", "Q93329", "WBGene00002975", "H2KZY7", "WBGene00022283", "species_372533" ] }, "reaction_10572694": { "compartment": "compartment_876", "id": "reaction_10572694", "reactome": "R-CEL-9649108", "name": "HTR3A pentamer binds 5HT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_114523", "species_10572692" ], "products": [ "species_10572687" ], "modifiers": [], "additional_components": [ "O76554", "WBGene00000955", "P54244", "WBGene00000951", "P54245", "WBGene00017580", "P54246", "WBGene00000044", "Q19351", "WBGene00017375", "Q22079", "WBGene00011354", "Q22080", "WBGene00011355", "Q22081", "WBGene00011356", "Q22083", "WBGene00011358", "Q22084", "WBGene00011360", "Q22085", "WBGene00011359", "Q6BEQ0", "WBGene00013338", "Q6F6K3", "WBGene00000056", "Q95Y94", "WBGene00020048", "Q9NAM5", "WBGene00013655", "V6CJ96", "WBGene00022247", "A0A3P6P985", "WBGene00000060", "B1Q281", "WBGene00000059", "G5ECT0", "WBGene00012857", "G5EG72", "WBGene00000057", "G5EG88", "WBGene00000062", "G5EGR1", "WBGene00000061", "H2KML8", "WBGene00013534", "O16426", "WBGene00020236", "O18228", "WBGene00013300", "O44452", "WBGene00015412", "O61519", "WBGene00017544", "O61520", "WBGene00017543", "O76554", "WBGene00000955", "P54244", "WBGene00000951", "P54245", "WBGene00017580", "P54246", "WBGene00000044", "Q19351", "WBGene00017375", "Q22079", "WBGene00011354", "Q22080", "WBGene00011355", "Q22081", "WBGene00011356", "Q22083", "WBGene00011358", "Q22084", "WBGene00011360", "Q22085", "WBGene00011359", "Q6BEQ0", "WBGene00013338", "Q6F6K3", "WBGene00000056", "Q95Y94", "WBGene00020048", "Q9NAM5", "WBGene00013655", "V6CJ96", "WBGene00022247", "A0A3P6P985", "WBGene00000060", "B1Q281", "WBGene00000059", "G5ECT0", "WBGene00012857", "G5EG72", "WBGene00000057", "G5EG88", "WBGene00000062", "G5EGR1", "WBGene00000061", "H2KML8", "WBGene00013534", "O16426", "WBGene00020236", "O18228", "WBGene00013300", "O44452", "WBGene00015412", "O61519", "WBGene00017544", "O61520", "WBGene00017543", "species_380585" ] }, "reaction_10571568": { "compartment": "compartment_7660", "id": "reaction_10571568", "reactome": "R-CEL-9029434", "name": "p-S363,S380,T573 RS6K translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10571566" ], "products": [ "species_10524491" ], "modifiers": [], "additional_components": [ "Q21734", "WBGene00011352", "Q19858", "WBGene00017898", "Q21734", "WBGene00011352", "Q19858", "WBGene00017898" ] }, "reaction_10524494": { "compartment": "compartment_7660", "id": "reaction_10524494", "reactome": "R-CEL-442724", "name": "Phosphorylation of CREB1 by ribosomal protein S6 kinases (RSKs)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10514243" ], "products": [ "species_113582", "species_10514246" ], "modifiers": [ [ "species_10524491", "catalyst" ] ], "additional_components": [ "WBGene00000793", "WBGene00000793", "Q21734", "WBGene00011352", "Q19858", "WBGene00017898" ] }, "reaction_10572227": { "compartment": "compartment_70101", "id": "reaction_10572227", "reactome": "R-CEL-9619355", "name": "CaMKK autophosphorylates in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10572220", "species_113592" ], "products": [ "species_29370", "species_10572224" ], "modifiers": [ [ "species_10572220", "catalyst" ] ], "additional_components": [ "species_74016", "Q11083", "WBGene00020378", "P04630", "WBGene00000285", "G5EF37", "WBGene00003934", "A0A2C9C3L3", "WBGene00020378", "Q18136", "WBGene00006861", "Q09665", "WBGene00006583", "O02159", "WBGene00020378", "G5EDZ8", "WBGene00000288", "Q94288", "WBGene00000287", "Q09980", "WBGene00017394", "O16305", "WBGene00000552", "G5EEG0", "WBGene00000286", "Q3Y416", "WBGene00000518", "species_74016", "Q11083", "WBGene00020378", "P04630", "WBGene00000285", "G5EF37", "WBGene00003934", "A0A2C9C3L3", "WBGene00020378", "Q18136", "WBGene00006861", "Q09665", "WBGene00006583", "O02159", "WBGene00020378", "G5EDZ8", "WBGene00000288", "Q94288", "WBGene00000287", "Q09980", "WBGene00017394", "O16305", "WBGene00000552", "G5EEG0", "WBGene00000286", "Q3Y416", "WBGene00000518", "species_74016", "Q11083", "WBGene00020378", "P04630", "WBGene00000285", "G5EF37", "WBGene00003934", "A0A2C9C3L3", "WBGene00020378", "Q18136", "WBGene00006861", "Q09665", "WBGene00006583", "O02159", "WBGene00020378", "G5EDZ8", "WBGene00000288", "Q94288", "WBGene00000287", "Q09980", "WBGene00017394", "O16305", "WBGene00000552", "G5EEG0", "WBGene00000286", "Q3Y416", "WBGene00000518" ] }, "reaction_10572236": { "compartment": "compartment_70101", "id": "reaction_10572236", "reactome": "R-CEL-9619376", "name": "CAMK1 binds calmodulin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10572232", "species_10508995" ], "products": [ "species_10572234" ], "modifiers": [], "additional_components": [ "WBGene00000553", "species_74016", "Q11083", "WBGene00020378", "P04630", "WBGene00000285", "G5EF37", "WBGene00003934", "A0A2C9C3L3", "WBGene00020378", "Q18136", "WBGene00006861", "Q09665", "WBGene00006583", "O02159", "WBGene00020378", "G5EDZ8", "WBGene00000288", "Q94288", "WBGene00000287", "Q09980", "WBGene00017394", "O16305", "WBGene00000552", "G5EEG0", "WBGene00000286", "species_74016", "Q11083", "WBGene00020378", "P04630", "WBGene00000285", "G5EF37", "WBGene00003934", "A0A2C9C3L3", "WBGene00020378", "Q18136", "WBGene00006861", "Q09665", "WBGene00006583", "O02159", "WBGene00020378", "G5EDZ8", "WBGene00000288", "Q94288", "WBGene00000287", "Q09980", "WBGene00017394", "O16305", "WBGene00000552", "G5EEG0", "WBGene00000286", "Q9TXJ0", "WBGene00000553" ] }, "reaction_10523910": { "compartment": "compartment_984", "id": "reaction_10523910", "reactome": "R-CEL-432164", "name": "Ca2+ influx into the post-synaptic cell", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74112" ], "products": [ "species_74016" ], "modifiers": [ [ "species_10523907", "catalyst" ], [ "species_9635195", "inhibitor" ] ], "additional_components": [ "G5ECY0", "WBGene00001006", "Q22638", "WBGene00011890", "G5EEH3", "WBGene00003775", "G5EGQ9", "WBGene00003774", "Q23158", "WBGene00000228", "O61967", "WBGene00002632", "O62305", "WBGene00006779", "species_376186", "species_159549", "species_113552" ] }, "reaction_10524270": { "compartment": "compartment_876", "id": "reaction_10524270", "reactome": "R-CEL-438037", "name": "Membrane depolarization upon activation of Ca impermeable AMPA receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74113" ], "products": [ "species_83910" ], "modifiers": [ [ "species_10521150", "catalyst" ], [ "species_10524268", "catalyst" ] ], "additional_components": [ "Q10914", "WBGene00001613", "Q21415", "WBGene00001614", "Q8MXV8", "WBGene00001617", "P34299", "WBGene00001612", "species_113552", "O61967", "WBGene00002632", "G5ECY0", "WBGene00001006", "Q22638", "WBGene00011890", "G5EGQ9", "WBGene00003774", "G5EEH3", "WBGene00003775", "Q23158", "WBGene00000228", "O62305", "WBGene00006779", "species_376186", "species_159549", "species_113552", "species_74016", "Q11083", "WBGene00020378", "P04630", "WBGene00000285", "G5EF37", "WBGene00003934", "A0A2C9C3L3", "WBGene00020378", "Q18136", "WBGene00006861", "Q09665", "WBGene00006583", "O02159", "WBGene00020378", "G5EDZ8", "WBGene00000288", "Q94288", "WBGene00000287", "Q09980", "WBGene00017394", "O16305", "WBGene00000552", "G5EEG0", "WBGene00000286" ] }, "reaction_10571984": { "compartment": "compartment_12045", "id": "reaction_10571984", "reactome": "R-CEL-9609742", "name": "Formation of di-heterotetramers of GluN1 (GRIN1) and GluN2A (GRIN2A)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10571980", "species_10571978" ], "products": [ "species_10571982" ], "modifiers": [], "additional_components": [ "WBGene00003775", "WBGene00003774", "G5EGQ9", "WBGene00003774", "G5EEH3", "WBGene00003775" ] }, "reaction_10572100": { "compartment": "compartment_12045", "id": "reaction_10572100", "reactome": "R-CEL-9610750", "name": "GluN1:GluN2 (GRIN1:GRIN2) NMDA receptors traffic to the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10572098" ], "products": [ "species_10523874" ], "modifiers": [], "additional_components": [ "G5EEH3", "WBGene00003775", "G5EGQ9", "WBGene00003774", "G5EEH3", "WBGene00003775", "G5EGQ9", "WBGene00003774" ] }, "reaction_10530193": { "compartment": "compartment_876", "id": "reaction_10530193", "reactome": "R-CEL-975340", "name": "GABR heteropentamers:GABA transport Cl- from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_188972" ], "products": [ "species_352022" ], "modifiers": [ [ "species_10530190", "catalyst" ] ], "additional_components": [ "species_352003", "Q6BET0", "WBGene00008551", "G5ECN1", "WBGene00013914", "A5JYS3", "WBGene00045385", "Q17999", "WBGene00007594", "G5ECD3", "WBGene00006784", "Q4W520", "WBGene00044301", "G5ECJ0", "WBGene00001373", "A0A3P6NNS2", "WBGene00017389", "Q9U2E2", "WBGene00012915", "O18276", "WBGene00001512" ] }, "reaction_10530517": { "compartment": "compartment_876", "id": "reaction_10530517", "reactome": "R-CEL-975449", "name": "GABRR pentamers:GABA transports extracellular Cl- to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_188972" ], "products": [ "species_352022" ], "modifiers": [ [ "species_10530514", "catalyst" ] ], "additional_components": [ "Q4W520", "WBGene00044301", "Q9U2E2", "WBGene00012915", "A0A3P6NNS2", "WBGene00017389", "A5JYS3", "WBGene00045385", "G5ECD3", "WBGene00006784", "G5ECJ0", "WBGene00001373", "O18276", "WBGene00001512", "Q17999", "WBGene00007594", "species_352003" ] }, "reaction_10531856": { "compartment": "compartment_876", "id": "reaction_10531856", "reactome": "R-CEL-1013013", "name": "Association of GABA B receptor with G protein beta-gamma subunits", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509165", "species_10519831" ], "products": [ "species_10531752" ], "modifiers": [ [ "species_10519831", "catalyst" ] ], "additional_components": [ "P17343", "WBGene00001679", "P54406", "WBGene00001681", "G5ECB2", "WBGene00022675", "H2L0Q3", "WBGene00021528", "species_352003", "G5ECB2", "WBGene00022675", "H2L0Q3", "WBGene00021528", "species_352003", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "G5ECB2", "WBGene00022675", "H2L0Q3", "WBGene00021528", "species_352003" ] }, "reaction_10531859": { "compartment": "compartment_70101", "id": "reaction_10531859", "reactome": "R-CEL-1013020", "name": "Activation of GIRK/Kir3 Channels", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10531851", "catalyst" ] ], "additional_components": [ "G5ECB2", "WBGene00022675", "H2L0Q3", "WBGene00021528", "species_352003", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "A0A1C3NSK2", "WBGene00002151", "A0A1C3NSN6", "WBGene00002150", "P52192", "WBGene00002149" ] }, "reaction_10531854": { "compartment": "compartment_876", "id": "reaction_10531854", "reactome": "R-CEL-1013012", "name": "Binding of Gbeta/gamma to GIRK/Kir3 channels", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10531849", "species_10531752" ], "products": [ "species_10531851" ], "modifiers": [ [ "species_10519831", "catalyst" ] ], "additional_components": [ "A0A1C3NSK2", "WBGene00002151", "A0A1C3NSN6", "WBGene00002150", "P52192", "WBGene00002149", "G5ECB2", "WBGene00022675", "H2L0Q3", "WBGene00021528", "species_352003", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "G5ECB2", "WBGene00022675", "H2L0Q3", "WBGene00021528", "species_352003", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "A0A1C3NSK2", "WBGene00002151", "A0A1C3NSN6", "WBGene00002150", "P52192", "WBGene00002149", "G5ECB2", "WBGene00022675", "H2L0Q3", "WBGene00021528", "species_352003" ] }, "reaction_10522049": { "compartment": "compartment_984", "id": "reaction_10522049", "reactome": "R-CEL-420977", "name": "Ca permeable AMPA receptor ligand binding", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_210382", "species_10521159" ], "products": [ "species_10521161" ], "modifiers": [], "additional_components": [ "Q10914", "WBGene00001613", "Q21415", "WBGene00001614", "Q8MXV8", "WBGene00001617", "P34299", "WBGene00001612", "Q10914", "WBGene00001613", "Q21415", "WBGene00001614", "Q8MXV8", "WBGene00001617", "P34299", "WBGene00001612", "species_113552" ] }, "reaction_10521153": { "compartment": "compartment_876", "id": "reaction_10521153", "reactome": "R-CEL-399711", "name": "Activation of Ca impermeable AMPA receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74113" ], "products": [ "species_83910" ], "modifiers": [ [ "species_10521150", "catalyst" ] ], "additional_components": [ "Q10914", "WBGene00001613", "Q21415", "WBGene00001614", "Q8MXV8", "WBGene00001617", "P34299", "WBGene00001612", "species_113552" ] }, "reaction_10522051": { "compartment": "compartment_876", "id": "reaction_10522051", "reactome": "R-CEL-420980", "name": "Activation of Ca permeable AMPA receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74113" ], "products": [ "species_83910" ], "modifiers": [ [ "species_10521161", "catalyst" ] ], "additional_components": [ "Q10914", "WBGene00001613", "Q21415", "WBGene00001614", "Q8MXV8", "WBGene00001617", "P34299", "WBGene00001612", "species_113552" ] }, "reaction_10522047": { "compartment": "compartment_984", "id": "reaction_10522047", "reactome": "R-CEL-420975", "name": "Ca impermeable AMPA receptor ligand binding", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_210382", "species_10521148" ], "products": [ "species_10521150" ], "modifiers": [], "additional_components": [ "Q10914", "WBGene00001613", "Q21415", "WBGene00001614", "Q8MXV8", "WBGene00001617", "P34299", "WBGene00001612", "Q10914", "WBGene00001613", "Q21415", "WBGene00001614", "Q8MXV8", "WBGene00001617", "P34299", "WBGene00001612", "species_113552" ] }, "reaction_10530046": { "compartment": "compartment_876", "id": "reaction_10530046", "reactome": "R-CEL-975311", "name": "HTR3 pentamers:5HT transport Na+,K+,Ca2+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74126", "species_74112", "species_74113" ], "products": [ "species_29804", "species_83910", "species_74016" ], "modifiers": [ [ "species_10530043", "catalyst" ] ], "additional_components": [ "O76554", "WBGene00000955", "P54244", "WBGene00000951", "P54245", "WBGene00017580", "P54246", "WBGene00000044", "Q19351", "WBGene00017375", "Q22079", "WBGene00011354", "Q22080", "WBGene00011355", "Q22081", "WBGene00011356", "Q22083", "WBGene00011358", "Q22084", "WBGene00011360", "Q22085", "WBGene00011359", "Q6BEQ0", "WBGene00013338", "Q6F6K3", "WBGene00000056", "Q95Y94", "WBGene00020048", "Q9NAM5", "WBGene00013655", "V6CJ96", "WBGene00022247", "A0A3P6P985", "WBGene00000060", "B1Q281", "WBGene00000059", "G5ECT0", "WBGene00012857", "G5EG72", "WBGene00000057", "G5EG88", "WBGene00000062", "G5EGR1", "WBGene00000061", "H2KML8", "WBGene00013534", "O16426", "WBGene00020236", "O18228", "WBGene00013300", "O44452", "WBGene00015412", "O61519", "WBGene00017544", "O61520", "WBGene00017543", "species_380585" ] }, "reaction_10518753": { "compartment": "compartment_876", "id": "reaction_10518753", "reactome": "R-CEL-374680", "name": "L1 trans-homophilic interaction", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10518718", "species_10518749" ], "products": [ "species_10518751" ], "modifiers": [], "additional_components": [ "Q21465", "WBGene00019727", "Q5WRR1", "WBGene00006942", "G5EBK3", "WBGene00001333", "species_179856", "Q21465", "WBGene00019727", "Q5WRR1", "WBGene00006942", "G5EBK3", "WBGene00001333", "species_179856", "Q21465", "WBGene00019727", "Q5WRR1", "WBGene00006942" ] }, "reaction_10524545": { "compartment": "compartment_70101", "id": "reaction_10524545", "reactome": "R-CEL-443779", "name": "Linkage of L1 with treadmilling F-actin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10518751", "species_10523755" ], "products": [ "species_10524543" ], "modifiers": [], "additional_components": [ "G5EBK3", "WBGene00001333", "species_179856", "Q21465", "WBGene00019727", "Q5WRR1", "WBGene00006942", "P0DM41", "WBGene00000063", "P0DM42", "WBGene00000065", "P10984", "WBGene00000064", "P10986", "WBGene00000066", "species_29358", "P0DM41", "WBGene00000063", "P0DM42", "WBGene00000065", "P10984", "WBGene00000064", "P10986", "WBGene00000066", "species_29358", "G5EBK3", "WBGene00001333", "species_179856", "Q21465", "WBGene00019727", "Q5WRR1", "WBGene00006942" ] }, "reaction_10521063": { "compartment": "compartment_876", "id": "reaction_10521063", "reactome": "R-CEL-392748", "name": "L1 binds to AP-2 Clathrin complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10518718", "species_10512100" ], "products": [ "species_10521061" ], "modifiers": [], "additional_components": [ "Q21465", "WBGene00019727", "Q5WRR1", "WBGene00006942", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q21465", "WBGene00019727", "Q5WRR1", "WBGene00006942" ] }, "reaction_10527463": { "compartment": "compartment_876", "id": "reaction_10527463", "reactome": "R-CEL-555065", "name": "Formation of clathrin coated vesicle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10512105", "species_10521061" ], "products": [ "species_29372", "species_29420", "species_10521065" ], "modifiers": [ [ "species_10512940", "catalyst" ] ], "additional_components": [ "WBGene00006791", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q21465", "WBGene00019727", "Q5WRR1", "WBGene00006942", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "B1V8A0", "WBGene00006791", "Q21465", "WBGene00019727", "Q5WRR1", "WBGene00006942" ] }, "reaction_10524730": { "compartment": "compartment_70101", "id": "reaction_10524730", "reactome": "R-CEL-445079", "name": "Phosphorylation of L1 by ERK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10521065", "species_113592", "species_10508599" ], "products": [ "species_29370", "species_10524727" ], "modifiers": [ [ "species_10508599", "catalyst" ] ], "additional_components": [ "P34574", "WBGene00011867", "P90961", "WBGene00020246", "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "B1V8A0", "WBGene00006791", "Q21465", "WBGene00019727", "Q5WRR1", "WBGene00006942", "WBGene00003401", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q5WRR1", "WBGene00006942", "Q21465", "WBGene00019727", "P39745", "WBGene00003401", "B1V8A0", "WBGene00006791", "WBGene00003401" ] }, "reaction_10521067": { "compartment": "compartment_17940", "id": "reaction_10521067", "reactome": "R-CEL-392749", "name": "Transport of L1 into endosomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10521065" ], "products": [ "species_10521065" ], "modifiers": [], "additional_components": [ "P34574", "WBGene00011867", "P90961", "WBGene00020246", "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "B1V8A0", "WBGene00006791", "Q21465", "WBGene00019727", "Q5WRR1", "WBGene00006942", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "B1V8A0", "WBGene00006791", "Q21465", "WBGene00019727", "Q5WRR1", "WBGene00006942" ] }, "reaction_10524732": { "compartment": "compartment_70101", "id": "reaction_10524732", "reactome": "R-CEL-445084", "name": "Phosphorylation of L1 by SRC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10518718", "species_113592" ], "products": [ "species_10518747", "species_29370" ], "modifiers": [ [ "species_10513079", "catalyst" ] ], "additional_components": [ "Q21465", "WBGene00019727", "Q5WRR1", "WBGene00006942", "Q21465", "WBGene00019727", "Q5WRR1", "WBGene00006942", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635" ] }, "reaction_10524556": { "compartment": "compartment_876", "id": "reaction_10524556", "reactome": "R-CEL-443783", "name": "Interaction of NUMB with L1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10518718", "species_10524552" ], "products": [ "species_10524554" ], "modifiers": [], "additional_components": [ "Q21465", "WBGene00019727", "Q5WRR1", "WBGene00006942", "Q22601", "WBGene00000161", "Q9XTY6", "WBGene00003830", "Q18677", "WBGene00000964", "Q21773", "WBGene00000963", "Q01630", "WBGene00006769", "Q22601", "WBGene00000161", "Q9XTY6", "WBGene00003830", "Q18677", "WBGene00000964", "Q21773", "WBGene00000963", "Q01630", "WBGene00006769", "Q21465", "WBGene00019727", "Q5WRR1", "WBGene00006942" ] }, "reaction_10566112": { "compartment": "compartment_7660", "id": "reaction_10566112", "reactome": "R-CEL-8864278", "name": "AP-2 (TFAP2) transcription factors form homo- and heterodimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10566108" ], "products": [ "species_10566110" ], "modifiers": [], "additional_components": [ "Q09585", "WBGene00019424", "Q19862", "WBGene00009203", "Q19863", "WBGene00009202", "G2HK15", "WBGene00013383", "Q09585", "WBGene00019424", "Q19862", "WBGene00009203", "Q19863", "WBGene00009202", "G2HK15", "WBGene00013383" ] }, "reaction_10566136": { "compartment": "compartment_7660", "id": "reaction_10566136", "reactome": "R-CEL-8864595", "name": "TFAP2B homodimer binds YEATS4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10566132", "species_10566130" ], "products": [ "species_10566134" ], "modifiers": [], "additional_components": [ "Q09585", "WBGene00019424", "Q19862", "WBGene00009203", "Q19863", "WBGene00009202", "G2HK15", "WBGene00013383", "WBGene00001585", "Q21501", "WBGene00001585", "Q09585", "WBGene00019424", "Q19862", "WBGene00009203", "Q19863", "WBGene00009202", "G2HK15", "WBGene00013383" ] }, "reaction_10566124": { "compartment": "compartment_70101", "id": "reaction_10566124", "reactome": "R-CEL-8864577", "name": "TFAP2C translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10566118" ], "products": [ "species_10546739" ], "modifiers": [ [ "species_10566120", "inhibitor" ] ], "additional_components": [ "WBGene00019424", "WBGene00019424", "Q09585", "WBGene00019424", "Q19062", "WBGene00000971" ] }, "reaction_10546753": { "compartment": "compartment_7660", "id": "reaction_10546753", "reactome": "R-CEL-3234094", "name": "SUMOylation of TFAP2C with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546741", "species_10546081" ], "products": [ "species_10546751", "species_10546073" ], "modifiers": [ [ "species_10546081", "catalyst" ] ], "additional_components": [ "Q09585", "WBGene00019424", "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "Q09585", "WBGene00019424", "P55853", "WBGene00004888", "WBGene00006706", "Q95017", "WBGene00006706", "P55853", "WBGene00004888" ] }, "reaction_10566122": { "compartment": "compartment_70101", "id": "reaction_10566122", "reactome": "R-CEL-8864569", "name": "WWOX binds TFAP2C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10532620", "species_10566118" ], "products": [ "species_10566120" ], "modifiers": [], "additional_components": [ "WBGene00000971", "WBGene00019424", "Q09585", "WBGene00019424", "Q19062", "WBGene00000971" ] }, "reaction_10529266": { "compartment": "compartment_70101", "id": "reaction_10529266", "reactome": "R-CEL-927789", "name": "Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10529262", "species_10529242" ], "products": [ "species_10529264" ], "modifiers": [], "additional_components": [ "P91914", "WBGene00004441", "Q19869", "WBGene00004440", "O01868", "WBGene00004436", "P48162", "WBGene00004438", "P52819", "WBGene00004434", "P48158", "WBGene00004435", "Q09533", "WBGene00004421", "P34334", "WBGene00004433", "O02639", "WBGene00004431", "Q95Y90", "WBGene00004420", "O44480", "WBGene00004432", "Q22716", "WBGene00004446", "Q9U332", "WBGene00004445", "Q9XWS4", "WBGene00004444", "P52814", "WBGene00004453", "O45226", "WBGene00004443", "Q21930", "WBGene00004442", "P48166", "WBGene00004454", "Q9BKU5", "WBGene00021350", "P50880", "WBGene00004414", "P61866", "WBGene00004424", "O17570", "WBGene00004452", "Q19162", "WBGene00004423", "Q9U2A8", "WBGene00004456", "Q9N4I4", "WBGene00004412", "O62388", "WBGene00012179", "O01504", "WBGene00016493", "P49181", "WBGene00004450", "P91913", "WBGene00004409", "P49180", "WBGene00004447", "Q93572", "WBGene00004408", "P34662", "WBGene00004449", "Q9XVF7", "WBGene00004413", "O45946", "WBGene00004430", "Q966C6", "WBGene00004419", "Q9BL19", "WBGene00004429", "O01802", "WBGene00004418", "P91374", "WBGene00004427", "P47991", "WBGene00004417", "Q9XVE9", "WBGene00004426", "P49405", "WBGene00004416", "Q27389", "WBGene00004428", "P37165", "WBGene00006725", "P91128", "WBGene00004425", "O02056", "WBGene00004415", "P51403", "WBGene00004471", "Q9NEN6", "WBGene00004475", "Q8WQA8", "WBGene00004489", "Q23312", "WBGene00004476", "O01869", "WBGene00004479", "P49197", "WBGene00004490", "P48156", "WBGene00004477", "Q20206", "WBGene00004480", "Q19877", "WBGene00004492", "Q20228", "WBGene00004478", "P49196", "WBGene00004481", "Q1XFY9", "WBGene00004493", "P46769", "WBGene00004469", "P51404", "WBGene00004482", "P52821", "WBGene00004494", "Q9TXP0", "WBGene00004496", "P48150", "WBGene00004483", "O45499", "WBGene00004495", "Q9N3X2", "WBGene00004473", "Q9XVP0", "WBGene00004484", "Q95Y04", "WBGene00004497", "Q22054", "WBGene00004485", "P90983", "WBGene00004498", "O01692", "WBGene00004486", "P48152", "WBGene00004472", "O18240", "WBGene00004487", "O18650", "WBGene00004488", "P48154", "WBGene00004470", "O17218", "WBGene00004491", "P49041", "WBGene00004474", "O45622", "WBGene00010405", "species_29420", "A0A486WX07", "WBGene00002066", "Q9U302", "WBGene00003902", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "O16520", "WBGene00020269", "WBGene00004880", "O76512", "WBGene00004880", "P91914", "WBGene00004441", "Q19869", "WBGene00004440", "O01868", "WBGene00004436", "P48162", "WBGene00004438", "P52819", "WBGene00004434", "P48158", "WBGene00004435", "Q09533", "WBGene00004421", "P34334", "WBGene00004433", "O02639", "WBGene00004431", "Q95Y90", "WBGene00004420", "O44480", "WBGene00004432", "Q22716", "WBGene00004446", "Q9U332", "WBGene00004445", "Q9XWS4", "WBGene00004444", "P52814", "WBGene00004453", "O45226", "WBGene00004443", "Q21930", "WBGene00004442", "P48166", "WBGene00004454", "Q9BKU5", "WBGene00021350", "P50880", "WBGene00004414", "P61866", "WBGene00004424", "O17570", "WBGene00004452", "Q19162", "WBGene00004423", "Q9U2A8", "WBGene00004456", "Q9N4I4", "WBGene00004412", "O62388", "WBGene00012179", "O01504", "WBGene00016493", "P49181", "WBGene00004450", "P91913", "WBGene00004409", "P49180", "WBGene00004447", "Q93572", "WBGene00004408", "P34662", "WBGene00004449", "Q9XVF7", "WBGene00004413", "O45946", "WBGene00004430", "Q966C6", "WBGene00004419", "Q9BL19", "WBGene00004429", "O01802", "WBGene00004418", "P91374", "WBGene00004427", "P47991", "WBGene00004417", "Q9XVE9", "WBGene00004426", "P49405", "WBGene00004416", "Q27389", "WBGene00004428", "P37165", "WBGene00006725", "P91128", "WBGene00004425", "O02056", "WBGene00004415", "P51403", "WBGene00004471", "Q9NEN6", "WBGene00004475", "Q8WQA8", "WBGene00004489", "Q23312", "WBGene00004476", "O01869", "WBGene00004479", "P49197", "WBGene00004490", "P48156", "WBGene00004477", "Q20206", "WBGene00004480", "Q19877", "WBGene00004492", "Q20228", "WBGene00004478", "P49196", "WBGene00004481", "Q1XFY9", "WBGene00004493", "P46769", "WBGene00004469", "P51404", "WBGene00004482", "P52821", "WBGene00004494", "Q9TXP0", "WBGene00004496", "P48150", "WBGene00004483", "O45499", "WBGene00004495", "Q9N3X2", "WBGene00004473", "Q9XVP0", "WBGene00004484", "Q95Y04", "WBGene00004497", "Q22054", "WBGene00004485", "P90983", "WBGene00004498", "O01692", "WBGene00004486", "P48152", "WBGene00004472", "O18240", "WBGene00004487", "O18650", "WBGene00004488", "P48154", "WBGene00004470", "O17218", "WBGene00004491", "P49041", "WBGene00004474", "O45622", "WBGene00010405", "species_29420", "A0A486WX07", "WBGene00002066", "Q9U302", "WBGene00003902", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "O16520", "WBGene00020269" ] }, "reaction_10508129": { "compartment": "compartment_7660", "id": "reaction_10508129", "reactome": "R-CEL-77068", "name": "Activation of GT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508127" ], "products": [ "species_10508127" ], "modifiers": [], "additional_components": [ "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q17607", "WBGene00000466", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q17607", "WBGene00000466" ] }, "reaction_10508162": { "compartment": "compartment_7660", "id": "reaction_10508162", "reactome": "R-CEL-77078", "name": "Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508155" ], "products": [ "species_113550", "species_10508159" ], "modifiers": [ [ "species_10508155", "catalyst" ] ], "additional_components": [ "Q21338", "WBGene00005015", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q17607", "WBGene00000466", "Q9XVS1", "WBGene00006447", "Q21338", "WBGene00005015", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q17607", "WBGene00000466", "Q9XVS1", "WBGene00006447", "Q21338", "WBGene00005015", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q17607", "WBGene00000466", "Q9XVS1", "WBGene00006447" ] }, "reaction_10508178": { "compartment": "compartment_7660", "id": "reaction_10508178", "reactome": "R-CEL-77085", "name": "Dissociation of transcript with 5'-GMP from GT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508171" ], "products": [ "species_10508176" ], "modifiers": [], "additional_components": [ "Q21338", "WBGene00005015", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q17607", "WBGene00000466", "Q9XVS1", "WBGene00006447", "Q21338", "WBGene00005015", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q17607", "WBGene00000466", "Q9XVS1", "WBGene00006447" ] }, "reaction_10508133": { "compartment": "compartment_7660", "id": "reaction_10508133", "reactome": "R-CEL-77069", "name": "RNA Polymerase II CTD (phosphorylated) binds to CE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508125", "species_10508131" ], "products": [ "species_10508127" ], "modifiers": [], "additional_components": [ "WBGene00000466", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q17607", "WBGene00000466" ] }, "reaction_10508183": { "compartment": "compartment_7660", "id": "reaction_10508183", "reactome": "R-CEL-77090", "name": "Methylation of GMP-cap by RNA Methyltransferase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10508176" ], "products": [ "species_77502", "species_10506316", "species_10504425", "species_10508149", "species_10508180" ], "modifiers": [ [ "species_10508176", "catalyst" ] ], "additional_components": [ "Q21338", "WBGene00005015", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q17607", "WBGene00000466", "Q9XVS1", "WBGene00006447", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "WBGene00005015", "Q17607", "WBGene00000466", "Q9XVS1", "WBGene00006447", "Q21338", "WBGene00005015", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q17607", "WBGene00000466", "Q9XVS1", "WBGene00006447" ] }, "reaction_10508169": { "compartment": "compartment_7660", "id": "reaction_10508169", "reactome": "R-CEL-77081", "name": "Formation of the CE:GMP intermediate complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508159", "species_113571" ], "products": [ "species_10508166", "species_111349" ], "modifiers": [ [ "species_10508159", "catalyst" ] ], "additional_components": [ "Q21338", "WBGene00005015", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q17607", "WBGene00000466", "Q9XVS1", "WBGene00006447", "Q21338", "WBGene00005015", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q17607", "WBGene00000466", "Q9XVS1", "WBGene00006447", "species_113578", "Q21338", "WBGene00005015", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q17607", "WBGene00000466", "Q9XVS1", "WBGene00006447" ] }, "reaction_10508185": { "compartment": "compartment_7660", "id": "reaction_10508185", "reactome": "R-CEL-77094", "name": "Formation of cap binding complex (CBC)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10504344", "species_10504339" ], "products": [ "species_10504346" ], "modifiers": [], "additional_components": [ "WBGene00018156", "WBGene00009141", "Q93594", "WBGene00009141", "O01763", "WBGene00018156" ] }, "reaction_10508153": { "compartment": "compartment_7660", "id": "reaction_10508153", "reactome": "R-CEL-77073", "name": "SPT5 subunit of Pol II binds the RNA triphosphatase (RTP)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508143", "species_10508127", "species_10508149" ], "products": [ "species_10508151" ], "modifiers": [], "additional_components": [ "WBGene00006447", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q17607", "WBGene00000466", "WBGene00005015", "Q21338", "WBGene00005015", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q17607", "WBGene00000466", "Q9XVS1", "WBGene00006447" ] }, "reaction_10508187": { "compartment": "compartment_7660", "id": "reaction_10508187", "reactome": "R-CEL-77095", "name": "Recognition and binding of the mRNA cap by the cap-binding complex ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10504346", "species_10504425" ], "products": [ "species_10504427" ], "modifiers": [], "additional_components": [ "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q93594", "WBGene00009141", "O01763", "WBGene00018156" ] }, "reaction_10508157": { "compartment": "compartment_7660", "id": "reaction_10508157", "reactome": "R-CEL-77077", "name": "Capping complex formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508151", "species_72084", "species_29428" ], "products": [ "species_10508155" ], "modifiers": [], "additional_components": [ "Q21338", "WBGene00005015", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q17607", "WBGene00000466", "Q9XVS1", "WBGene00006447", "Q21338", "WBGene00005015", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q17607", "WBGene00000466", "Q9XVS1", "WBGene00006447" ] }, "reaction_10508174": { "compartment": "compartment_7660", "id": "reaction_10508174", "reactome": "R-CEL-77083", "name": "Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508166" ], "products": [ "species_10508171" ], "modifiers": [ [ "species_10508166", "catalyst" ] ], "additional_components": [ "Q21338", "WBGene00005015", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q17607", "WBGene00000466", "Q9XVS1", "WBGene00006447", "species_113578", "Q21338", "WBGene00005015", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q17607", "WBGene00000466", "Q9XVS1", "WBGene00006447", "Q21338", "WBGene00005015", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q17607", "WBGene00000466", "Q9XVS1", "WBGene00006447", "species_113578" ] }, "reaction_10508321": { "compartment": "compartment_7660", "id": "reaction_10508321", "reactome": "R-CEL-77586", "name": "Cleavage of the 3'-end of Replication Dependent Histone Pre-mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508315" ], "products": [ "species_10508319", "species_10508313" ], "modifiers": [], "additional_components": [ "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "Q09599", "WBGene00000411", "Q20709", "WBGene00018740", "V6CKC3", "WBGene00021689", "Q9N4G9", "WBGene00004920", "Q7YWY5", "WBGene00010619", "Q9GYQ8", "WBGene00016791", "Q9XTU6", "WBGene00004919", "P91918", "WBGene00004915", "Q17348", "WBGene00004914", "P34659", "WBGene00004918", "Q93594", "WBGene00009141", "Q09599", "WBGene00000411", "O01763", "WBGene00018156", "Q20709", "WBGene00018740", "V6CKC3", "WBGene00021689", "Q9N4G9", "WBGene00004920", "Q7YWY5", "WBGene00010619", "Q9GYQ8", "WBGene00016791", "Q9XTU6", "WBGene00004919", "P91918", "WBGene00004915", "Q17348", "WBGene00004914", "P34659", "WBGene00004918" ] }, "reaction_10508283": { "compartment": "compartment_7660", "id": "reaction_10508283", "reactome": "R-CEL-77584", "name": "Binding of SLBP to Replication-Dependent Histone Pre-mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508279", "species_10508274" ], "products": [ "species_10508281" ], "modifiers": [], "additional_components": [ "WBGene00000411", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "Q09599", "WBGene00000411" ] }, "reaction_10508317": { "compartment": "compartment_7660", "id": "reaction_10508317", "reactome": "R-CEL-77585", "name": "Recruitment of U7 snRNP:ZFP100 complex to the SLBP Bound Pre-mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508313", "species_10508281" ], "products": [ "species_10508315" ], "modifiers": [], "additional_components": [ "Q20709", "WBGene00018740", "V6CKC3", "WBGene00021689", "Q9N4G9", "WBGene00004920", "Q7YWY5", "WBGene00010619", "Q9GYQ8", "WBGene00016791", "Q9XTU6", "WBGene00004919", "P91918", "WBGene00004915", "Q17348", "WBGene00004914", "P34659", "WBGene00004918", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "Q09599", "WBGene00000411", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "Q09599", "WBGene00000411", "Q20709", "WBGene00018740", "V6CKC3", "WBGene00021689", "Q9N4G9", "WBGene00004920", "Q7YWY5", "WBGene00010619", "Q9GYQ8", "WBGene00016791", "Q9XTU6", "WBGene00004919", "P91918", "WBGene00004915", "Q17348", "WBGene00004914", "P34659", "WBGene00004918" ] }, "reaction_10508337": { "compartment": "compartment_7660", "id": "reaction_10508337", "reactome": "R-CEL-77591", "name": "Binding of Cleavage factors and Poly(A)Polymerase to the CstF:CPSF:Pre-mRNA Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10505197", "species_10505213", "species_10508331", "species_10505225", "species_10505192" ], "products": [ "species_10508335" ], "modifiers": [], "additional_components": [ "WBGene00003904", "Q93716", "WBGene00009668", "C1P629", "WBGene00008362", "O45577", "WBGene00000774", "Q19864", "WBGene00000773", "Q19866", "WBGene00006307", "Q95PY8", "WBGene00013460", "U4PCM1", "WBGene00011051", "Q9N4C2", "WBGene00022301", "Q7YTG9", "WBGene00044329", "O17403", "WBGene00017313", "O16929", "WBGene00017797", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "P52874", "WBGene00010304", "Q09345", "WBGene00020092", "Q09995", "WBGene00011791", "Q9U2P3", "WBGene00012528", "G5EBX5", "WBGene00009658", "Q09995", "WBGene00011791", "Q9U2P3", "WBGene00012528", "G5EBX5", "WBGene00009658", "P52874", "WBGene00010304", "Q09345", "WBGene00020092", "O45577", "WBGene00000774", "Q19864", "WBGene00000773", "Q19866", "WBGene00006307", "Q95PY8", "WBGene00013460", "U4PCM1", "WBGene00011051", "Q9N4C2", "WBGene00022301", "Q7YTG9", "WBGene00044329", "O17403", "WBGene00017313", "O16929", "WBGene00017797", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "Q93716", "WBGene00009668", "C1P629", "WBGene00008362", "Q93233", "WBGene00003904" ] }, "reaction_10508341": { "compartment": "compartment_7660", "id": "reaction_10508341", "reactome": "R-CEL-77592", "name": "Cleavage of Intronless Pre-mRNA at 3'-end", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508335" ], "products": [ "species_10505213", "species_10505225", "species_10505175", "species_112165", "species_10508339" ], "modifiers": [], "additional_components": [ "Q09995", "WBGene00011791", "Q9U2P3", "WBGene00012528", "G5EBX5", "WBGene00009658", "P52874", "WBGene00010304", "Q09345", "WBGene00020092", "O45577", "WBGene00000774", "Q19864", "WBGene00000773", "Q19866", "WBGene00006307", "Q95PY8", "WBGene00013460", "U4PCM1", "WBGene00011051", "Q9N4C2", "WBGene00022301", "Q7YTG9", "WBGene00044329", "O17403", "WBGene00017313", "O16929", "WBGene00017797", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "Q93716", "WBGene00009668", "C1P629", "WBGene00008362", "Q93233", "WBGene00003904", "Q93716", "WBGene00009668", "C1P629", "WBGene00008362", "P52874", "WBGene00010304", "Q09345", "WBGene00020092", "O45577", "WBGene00000774", "Q19864", "WBGene00000773", "Q19866", "WBGene00006307", "Q93594", "WBGene00009141", "Q95PY8", "WBGene00013460", "U4PCM1", "WBGene00011051", "Q9N4C2", "WBGene00022301", "Q7YTG9", "WBGene00044329", "O17403", "WBGene00017313", "O16929", "WBGene00017797", "Q09995", "WBGene00011791", "Q9U2P3", "WBGene00012528", "G5EBX5", "WBGene00009658", "O01763", "WBGene00018156", "Q93233", "WBGene00003904" ] }, "reaction_10508329": { "compartment": "compartment_7660", "id": "reaction_10508329", "reactome": "R-CEL-77589", "name": "Recognition of AAUAAA sequence by CPSF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508325", "species_10505156" ], "products": [ "species_10508327" ], "modifiers": [], "additional_components": [ "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "Q95PY8", "WBGene00013460", "U4PCM1", "WBGene00011051", "Q9N4C2", "WBGene00022301", "Q7YTG9", "WBGene00044329", "O17403", "WBGene00017313", "O16929", "WBGene00017797", "Q95PY8", "WBGene00013460", "U4PCM1", "WBGene00011051", "Q9N4C2", "WBGene00022301", "Q7YTG9", "WBGene00044329", "O17403", "WBGene00017313", "O16929", "WBGene00017797", "Q93594", "WBGene00009141", "O01763", "WBGene00018156" ] }, "reaction_10508345": { "compartment": "compartment_7660", "id": "reaction_10508345", "reactome": "R-CEL-77593", "name": "Cleavage and polyadenylation of Intronless Pre-mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508335" ], "products": [ "species_10505213", "species_10505197", "species_10505225", "species_10505192", "species_10505175", "species_10508343" ], "modifiers": [], "additional_components": [ "Q09995", "WBGene00011791", "Q9U2P3", "WBGene00012528", "G5EBX5", "WBGene00009658", "P52874", "WBGene00010304", "Q09345", "WBGene00020092", "O45577", "WBGene00000774", "Q19864", "WBGene00000773", "Q19866", "WBGene00006307", "Q95PY8", "WBGene00013460", "U4PCM1", "WBGene00011051", "Q9N4C2", "WBGene00022301", "Q7YTG9", "WBGene00044329", "O17403", "WBGene00017313", "O16929", "WBGene00017797", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "Q93716", "WBGene00009668", "C1P629", "WBGene00008362", "Q93233", "WBGene00003904", "Q93716", "WBGene00009668", "C1P629", "WBGene00008362", "WBGene00003904", "P52874", "WBGene00010304", "Q09345", "WBGene00020092", "Q09995", "WBGene00011791", "Q9U2P3", "WBGene00012528", "G5EBX5", "WBGene00009658", "O45577", "WBGene00000774", "Q19864", "WBGene00000773", "Q19866", "WBGene00006307", "Q95PY8", "WBGene00013460", "U4PCM1", "WBGene00011051", "Q9N4C2", "WBGene00022301", "Q7YTG9", "WBGene00044329", "O17403", "WBGene00017313", "O16929", "WBGene00017797", "Q93594", "WBGene00009141", "O01763", "WBGene00018156" ] }, "reaction_10508333": { "compartment": "compartment_7660", "id": "reaction_10508333", "reactome": "R-CEL-77590", "name": "Recruitment of CstF to the CPSF Bound Pre-mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10505175", "species_10508327" ], "products": [ "species_10508331" ], "modifiers": [], "additional_components": [ "O45577", "WBGene00000774", "Q19864", "WBGene00000773", "Q19866", "WBGene00006307", "Q95PY8", "WBGene00013460", "U4PCM1", "WBGene00011051", "Q9N4C2", "WBGene00022301", "Q7YTG9", "WBGene00044329", "O17403", "WBGene00017313", "O16929", "WBGene00017797", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "O45577", "WBGene00000774", "Q19864", "WBGene00000773", "Q19866", "WBGene00006307", "Q95PY8", "WBGene00013460", "U4PCM1", "WBGene00011051", "Q9N4C2", "WBGene00022301", "Q7YTG9", "WBGene00044329", "O17403", "WBGene00017313", "O16929", "WBGene00017797", "Q93594", "WBGene00009141", "O01763", "WBGene00018156" ] }, "reaction_10508842": { "compartment": "compartment_7660", "id": "reaction_10508842", "reactome": "R-CEL-111437", "name": "Cleavage of the 3'-end of the Histone Pre-mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508838" ], "products": [ "species_10508313", "species_10508840" ], "modifiers": [], "additional_components": [ "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "Q20709", "WBGene00018740", "V6CKC3", "WBGene00021689", "Q9N4G9", "WBGene00004920", "Q7YWY5", "WBGene00010619", "Q9GYQ8", "WBGene00016791", "Q9XTU6", "WBGene00004919", "P91918", "WBGene00004915", "Q17348", "WBGene00004914", "P34659", "WBGene00004918", "Q20709", "WBGene00018740", "V6CKC3", "WBGene00021689", "Q9N4G9", "WBGene00004920", "Q7YWY5", "WBGene00010619", "Q9GYQ8", "WBGene00016791", "Q9XTU6", "WBGene00004919", "P91918", "WBGene00004915", "Q17348", "WBGene00004914", "P34659", "WBGene00004918", "Q93594", "WBGene00009141", "O01763", "WBGene00018156" ] }, "reaction_10508844": { "compartment": "compartment_7660", "id": "reaction_10508844", "reactome": "R-CEL-111438", "name": "Recruitment of U7 snRNP:ZFP100 complex to the Histone Pre-mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508313", "species_10508274" ], "products": [ "species_10508838" ], "modifiers": [], "additional_components": [ "Q20709", "WBGene00018740", "V6CKC3", "WBGene00021689", "Q9N4G9", "WBGene00004920", "Q7YWY5", "WBGene00010619", "Q9GYQ8", "WBGene00016791", "Q9XTU6", "WBGene00004919", "P91918", "WBGene00004915", "Q17348", "WBGene00004914", "P34659", "WBGene00004918", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "Q20709", "WBGene00018740", "V6CKC3", "WBGene00021689", "Q9N4G9", "WBGene00004920", "Q7YWY5", "WBGene00010619", "Q9GYQ8", "WBGene00016791", "Q9XTU6", "WBGene00004919", "P91918", "WBGene00004915", "Q17348", "WBGene00004914", "P34659", "WBGene00004918" ] }, "reaction_10527075": { "compartment": "compartment_70101", "id": "reaction_10527075", "reactome": "R-CEL-482788", "name": "p-S54,92,203-BRF1 binds 14-3-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10525899", "species_10507065" ], "products": [ "species_10527073" ], "modifiers": [], "additional_components": [ "G5EC86", "WBGene00003864", "Q09436", "WBGene00003231", "Q9XUB2", "WBGene00003230", "G5ECB9", "WBGene00003228", "Q20155", "WBGene00009532", "Q9XV46", "WBGene00003388", "G5EF15", "WBGene00004078", "Q23359", "WBGene00003865", "O02289", "WBGene00011376", "Q94131", "WBGene00004027", "O18251", "WBGene00013319", "Q9U1Y2", "WBGene00013797", "O45289", "WBGene00013797", "Q9U2V1", "WBGene00013797", "O45491", "WBGene00009537", "Q9U2V2", "WBGene00013797", "O45493", "WBGene00013797", "Q9U2V4", "WBGene00013794", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "G5EC86", "WBGene00003864", "Q09436", "WBGene00003231", "Q9XUB2", "WBGene00003230", "G5ECB9", "WBGene00003228", "Q20155", "WBGene00009532", "Q9XV46", "WBGene00003388", "G5EF15", "WBGene00004078", "Q23359", "WBGene00003865", "O02289", "WBGene00011376", "Q94131", "WBGene00004027", "O18251", "WBGene00013319", "Q9U1Y2", "WBGene00013797", "O45289", "WBGene00013797", "Q9U2V1", "WBGene00013797", "O45491", "WBGene00009537", "Q9U2V2", "WBGene00013797", "O45493", "WBGene00013797", "Q9U2V4", "WBGene00013794" ] }, "reaction_10525750": { "compartment": "compartment_70101", "id": "reaction_10525750", "reactome": "R-CEL-450406", "name": "p-S92,203-BRF1 binds 14-3-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10507065", "species_10525746" ], "products": [ "species_10525748" ], "modifiers": [], "additional_components": [ "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "O45491", "WBGene00009537", "Q9U2V2", "WBGene00013797", "O45493", "WBGene00013797", "Q9U2V4", "WBGene00013794", "G5EC86", "WBGene00003864", "Q09436", "WBGene00003231", "Q9XUB2", "WBGene00003230", "G5ECB9", "WBGene00003228", "Q20155", "WBGene00009532", "Q9XV46", "WBGene00003388", "G5EF15", "WBGene00004078", "Q23359", "WBGene00003865", "O02289", "WBGene00011376", "Q94131", "WBGene00004027", "O18251", "WBGene00013319", "Q9U1Y2", "WBGene00013797", "O45289", "WBGene00013797", "Q9U2V1", "WBGene00013797", "O45491", "WBGene00009537", "Q9U2V2", "WBGene00013797", "O45493", "WBGene00013797", "Q9U2V4", "WBGene00013794", "G5EC86", "WBGene00003864", "Q09436", "WBGene00003231", "Q9XUB2", "WBGene00003230", "G5ECB9", "WBGene00003228", "Q20155", "WBGene00009532", "Q9XV46", "WBGene00003388", "G5EF15", "WBGene00004078", "Q23359", "WBGene00003865", "O02289", "WBGene00011376", "Q94131", "WBGene00004027", "O18251", "WBGene00013319", "Q9U1Y2", "WBGene00013797", "O45289", "WBGene00013797", "Q9U2V1", "WBGene00013797", "P41932", "WBGene00003920", "Q20655", "WBGene00001502" ] }, "reaction_10525911": { "compartment": "compartment_70101", "id": "reaction_10525911", "reactome": "R-CEL-450488", "name": "BRF1 Complex recruits RNA degradation activities", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10525823", "species_10523562", "species_10523671", "species_10525907", "species_10523569" ], "products": [ "species_10525909" ], "modifiers": [], "additional_components": [ "O18251", "WBGene00013319", "O45289", "WBGene00013797", "O45491", "WBGene00009537", "O45493", "WBGene00013797", "Q09436", "WBGene00003231", "Q20155", "WBGene00009532", "Q23359", "WBGene00003865", "Q94131", "WBGene00004027", "Q9U1Y2", "WBGene00013797", "Q9U2V1", "WBGene00013797", "Q9U2V2", "WBGene00013797", "Q9U2V4", "WBGene00013794", "G5EC86", "WBGene00003864", "Q9XUB2", "WBGene00003230", "G5ECB9", "WBGene00003228", "Q9XV46", "WBGene00003388", "G5EF15", "WBGene00004078", "O02289", "WBGene00011376", "WBGene00021929", "Q95XD0", "WBGene00022232", "G5EDS8", "WBGene00009289", "Q95QG7", "WBGene00018305", "Q9N4P9", "WBGene00000202", "G5EG59", "WBGene00000798", "Q17533", "WBGene00007201", "Q20128", "WBGene00018154", "Q9XXD2", "WBGene00012966", "Q17632", "WBGene00001001", "Q93830", "WBGene00010325", "WBGene00012730", "WBGene00003582", "O62255", "WBGene00003582", "Q9BHK7", "WBGene00012730", "Q95XD0", "WBGene00022232", "G5EDS8", "WBGene00009289", "Q95QG7", "WBGene00018305", "Q9N4P9", "WBGene00000202", "G5EG59", "WBGene00000798", "Q17533", "WBGene00007201", "Q20128", "WBGene00018154", "Q9XXD2", "WBGene00012966", "Q17632", "WBGene00001001", "Q93830", "WBGene00010325", "Q9N363", "WBGene00021929", "O18251", "WBGene00013319", "O45289", "WBGene00013797", "O45491", "WBGene00009537", "O45493", "WBGene00013797", "Q09436", "WBGene00003231", "Q20155", "WBGene00009532", "Q23359", "WBGene00003865", "Q94131", "WBGene00004027", "Q9U1Y2", "WBGene00013797", "Q9U2V1", "WBGene00013797", "Q9U2V2", "WBGene00013797", "Q9U2V4", "WBGene00013794", "G5EC86", "WBGene00003864", "Q9XUB2", "WBGene00003230", "G5ECB9", "WBGene00003228", "Q9XV46", "WBGene00003388", "G5EF15", "WBGene00004078", "O02289", "WBGene00011376" ] }, "reaction_10525914": { "compartment": "compartment_70101", "id": "reaction_10525914", "reactome": "R-CEL-450490", "name": "Protein Kinase B/Akt phosphorylates BRF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10525823", "species_113592" ], "products": [ "species_29370", "species_10525746" ], "modifiers": [ [ "species_10513843", "catalyst" ] ], "additional_components": [ "O18251", "WBGene00013319", "O45289", "WBGene00013797", "O45491", "WBGene00009537", "O45493", "WBGene00013797", "Q09436", "WBGene00003231", "Q20155", "WBGene00009532", "Q23359", "WBGene00003865", "Q94131", "WBGene00004027", "Q9U1Y2", "WBGene00013797", "Q9U2V1", "WBGene00013797", "Q9U2V2", "WBGene00013797", "Q9U2V4", "WBGene00013794", "G5EC86", "WBGene00003864", "Q9XUB2", "WBGene00003230", "G5ECB9", "WBGene00003228", "Q9XV46", "WBGene00003388", "G5EF15", "WBGene00004078", "O02289", "WBGene00011376", "O45491", "WBGene00009537", "Q9U2V2", "WBGene00013797", "O45493", "WBGene00013797", "Q9U2V4", "WBGene00013794", "G5EC86", "WBGene00003864", "Q09436", "WBGene00003231", "Q9XUB2", "WBGene00003230", "G5ECB9", "WBGene00003228", "Q20155", "WBGene00009532", "Q9XV46", "WBGene00003388", "G5EF15", "WBGene00004078", "Q23359", "WBGene00003865", "O02289", "WBGene00011376", "Q94131", "WBGene00004027", "O18251", "WBGene00013319", "Q9U1Y2", "WBGene00013797", "O45289", "WBGene00013797", "Q9U2V1", "WBGene00013797", "Q9XTG7", "WBGene00000103", "G4S4W1", "WBGene00016980", "Q17941", "WBGene00000102" ] }, "reaction_10525932": { "compartment": "compartment_70101", "id": "reaction_10525932", "reactome": "R-CEL-450517", "name": "Butyrate Response Factor1 (BRF1) binds AU-rich element in 3' UTR of mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_450523", "species_10525821" ], "products": [ "species_10525823" ], "modifiers": [], "additional_components": [ "O18251", "WBGene00013319", "O45289", "WBGene00013797", "O45491", "WBGene00009537", "O45493", "WBGene00013797", "Q09436", "WBGene00003231", "Q20155", "WBGene00009532", "Q23359", "WBGene00003865", "Q94131", "WBGene00004027", "Q9U1Y2", "WBGene00013797", "Q9U2V1", "WBGene00013797", "Q9U2V2", "WBGene00013797", "Q9U2V4", "WBGene00013794", "G5EC86", "WBGene00003864", "Q9XUB2", "WBGene00003230", "G5ECB9", "WBGene00003228", "Q9XV46", "WBGene00003388", "G5EF15", "WBGene00004078", "O02289", "WBGene00011376", "O18251", "WBGene00013319", "O45289", "WBGene00013797", "O45491", "WBGene00009537", "O45493", "WBGene00013797", "Q09436", "WBGene00003231", "Q20155", "WBGene00009532", "Q23359", "WBGene00003865", "Q94131", "WBGene00004027", "Q9U1Y2", "WBGene00013797", "Q9U2V1", "WBGene00013797", "Q9U2V2", "WBGene00013797", "Q9U2V4", "WBGene00013794", "G5EC86", "WBGene00003864", "Q9XUB2", "WBGene00003230", "G5ECB9", "WBGene00003228", "Q9XV46", "WBGene00003388", "G5EF15", "WBGene00004078", "O02289", "WBGene00011376" ] }, "reaction_10525902": { "compartment": "compartment_70101", "id": "reaction_10525902", "reactome": "R-CEL-450474", "name": "MK2 phosphorylates BRF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10525823", "species_113592" ], "products": [ "species_10525899", "species_29370" ], "modifiers": [ [ "species_10512640", "catalyst" ] ], "additional_components": [ "O18251", "WBGene00013319", "O45289", "WBGene00013797", "O45491", "WBGene00009537", "O45493", "WBGene00013797", "Q09436", "WBGene00003231", "Q20155", "WBGene00009532", "Q23359", "WBGene00003865", "Q94131", "WBGene00004027", "Q9U1Y2", "WBGene00013797", "Q9U2V1", "WBGene00013797", "Q9U2V2", "WBGene00013797", "Q9U2V4", "WBGene00013794", "G5EC86", "WBGene00003864", "Q9XUB2", "WBGene00003230", "G5ECB9", "WBGene00003228", "Q9XV46", "WBGene00003388", "G5EF15", "WBGene00004078", "O02289", "WBGene00011376", "G5EC86", "WBGene00003864", "Q09436", "WBGene00003231", "Q9XUB2", "WBGene00003230", "G5ECB9", "WBGene00003228", "Q20155", "WBGene00009532", "Q9XV46", "WBGene00003388", "G5EF15", "WBGene00004078", "Q23359", "WBGene00003865", "O02289", "WBGene00011376", "Q94131", "WBGene00004027", "O18251", "WBGene00013319", "Q9U1Y2", "WBGene00013797", "O45289", "WBGene00013797", "Q9U2V1", "WBGene00013797", "O45491", "WBGene00009537", "Q9U2V2", "WBGene00013797", "O45493", "WBGene00013797", "Q9U2V4", "WBGene00013794", "Q21360", "WBGene00010681", "Q965G5", "WBGene00007007" ] }, "reaction_10525984": { "compartment": "compartment_70101", "id": "reaction_10525984", "reactome": "R-CEL-450620", "name": "p-S193-KSRP binds 14-3-3zeta in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10525928", "species_10525970" ], "products": [ "species_10525982" ], "modifiers": [], "additional_components": [ "Q17936", "WBGene00007534", "Q23487", "WBGene00022738", "Q9BLA0", "WBGene00016489", "P91393", "WBGene00019692", "Q20655", "WBGene00001502", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "P41932", "WBGene00003920", "P91393", "WBGene00019692", "Q17936", "WBGene00007534", "Q23487", "WBGene00022738", "Q9BLA0", "WBGene00016489" ] }, "reaction_10525783": { "compartment": "compartment_70101", "id": "reaction_10525783", "reactome": "R-CEL-450422", "name": "KSRP recruits RNA degradation activities", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10525774", "species_10523671", "species_10525779", "species_10523569" ], "products": [ "species_10525781" ], "modifiers": [], "additional_components": [ "Q17936", "WBGene00007534", "Q23487", "WBGene00022738", "Q9BLA0", "WBGene00016489", "P91393", "WBGene00019692", "Q95XD0", "WBGene00022232", "G5EDS8", "WBGene00009289", "Q95QG7", "WBGene00018305", "Q9N4P9", "WBGene00000202", "G5EG59", "WBGene00000798", "Q17533", "WBGene00007201", "Q20128", "WBGene00018154", "Q9XXD2", "WBGene00012966", "Q17632", "WBGene00001001", "Q93830", "WBGene00010325", "WBGene00010734", "WBGene00003582", "O62255", "WBGene00003582", "Q21412", "WBGene00010734", "Q95XD0", "WBGene00022232", "G5EDS8", "WBGene00009289", "Q95QG7", "WBGene00018305", "Q9N4P9", "WBGene00000202", "G5EG59", "WBGene00000798", "Q17533", "WBGene00007201", "Q20128", "WBGene00018154", "Q9XXD2", "WBGene00012966", "Q17632", "WBGene00001001", "Q93830", "WBGene00010325", "Q17936", "WBGene00007534", "Q23487", "WBGene00022738", "Q9BLA0", "WBGene00016489", "P91393", "WBGene00019692" ] }, "reaction_10525930": { "compartment": "compartment_70101", "id": "reaction_10525930", "reactome": "R-CEL-450499", "name": "Protein Kinase B (AKT) phosphorylates KSRP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10525772", "species_113592" ], "products": [ "species_29370", "species_10525928" ], "modifiers": [ [ "species_10513843", "catalyst" ] ], "additional_components": [ "Q17936", "WBGene00007534", "Q23487", "WBGene00022738", "Q9BLA0", "WBGene00016489", "P91393", "WBGene00019692", "Q17936", "WBGene00007534", "Q23487", "WBGene00022738", "Q9BLA0", "WBGene00016489", "P91393", "WBGene00019692", "Q9XTG7", "WBGene00000103", "G4S4W1", "WBGene00016980", "Q17941", "WBGene00000102" ] }, "reaction_10525964": { "compartment": "compartment_70101", "id": "reaction_10525964", "reactome": "R-CEL-450592", "name": "KSRP binds AU-rich element in 3' UTR of mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10525772", "species_450386" ], "products": [ "species_10525774" ], "modifiers": [], "additional_components": [ "Q17936", "WBGene00007534", "Q23487", "WBGene00022738", "Q9BLA0", "WBGene00016489", "P91393", "WBGene00019692", "Q17936", "WBGene00007534", "Q23487", "WBGene00022738", "Q9BLA0", "WBGene00016489", "P91393", "WBGene00019692" ] }, "reaction_10513160": { "compartment": "compartment_70101", "id": "reaction_10513160", "reactome": "R-CEL-191784", "name": "snRNA Cap hypermethylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10513152" ], "products": [ "species_10513139" ], "modifiers": [ [ "species_10513157", "catalyst" ] ], "additional_components": [ "G5ED26", "WBGene00020284", "G5EC16", "WBGene00004887", "P34399", "WBGene00017357", "O01871", "WBGene00017002", "Q9N405", "WBGene00004886", "A7LPI7", "WBGene00007702", "Q9XTU6", "WBGene00004919", "P34659", "WBGene00004918", "Q9N4G9", "WBGene00004920", "P91918", "WBGene00004915", "Q10013", "WBGene00004916", "Q18786", "WBGene00004917", "Q17348", "WBGene00004914", "CHEBI:2274", "CHEBI:1604", "G5ED26", "WBGene00020284", "G5EC16", "WBGene00004887", "P34399", "WBGene00017357", "O01871", "WBGene00017002", "Q9N405", "WBGene00004886", "A7LPI7", "WBGene00007702", "Q9XTU6", "WBGene00004919", "P34659", "WBGene00004918", "Q9N4G9", "WBGene00004920", "P91918", "WBGene00004915", "Q10013", "WBGene00004916", "Q18786", "WBGene00004917", "Q17348", "WBGene00004914", "WBGene00011631" ] }, "reaction_10513148": { "compartment": "compartment_70101", "id": "reaction_10513148", "reactome": "R-CEL-191763", "name": "snRNP:Snurportin complex formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10513144", "species_10513139" ], "products": [ "species_10513146" ], "modifiers": [], "additional_components": [ "WBGene00017746", "CHEBI:1604", "G5ED26", "WBGene00020284", "G5EC16", "WBGene00004887", "P34399", "WBGene00017357", "O01871", "WBGene00017002", "Q9N405", "WBGene00004886", "A7LPI7", "WBGene00007702", "Q9XTU6", "WBGene00004919", "P34659", "WBGene00004918", "Q9N4G9", "WBGene00004920", "P91918", "WBGene00004915", "Q10013", "WBGene00004916", "Q18786", "WBGene00004917", "Q17348", "WBGene00004914", "CHEBI:1604", "O17066", "WBGene00017746", "G5ED26", "WBGene00020284", "G5EC16", "WBGene00004887", "P34399", "WBGene00017357", "O01871", "WBGene00017002", "Q9N405", "WBGene00004886", "A7LPI7", "WBGene00007702", "Q9XTU6", "WBGene00004919", "P34659", "WBGene00004918", "Q9N4G9", "WBGene00004920", "P91918", "WBGene00004915", "Q10013", "WBGene00004916", "Q18786", "WBGene00004917", "Q17348", "WBGene00004914" ] }, "reaction_10523617": { "compartment": "compartment_70101", "id": "reaction_10523617", "reactome": "R-CEL-430021", "name": "PAN2-PAN3 complex partially deadenylates mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10523602" ], "products": [ "species_10523590", "species_76577" ], "modifiers": [ [ "species_10523614", "catalyst" ] ], "additional_components": [ "A0A486WX07", "WBGene00002066", "Q20935", "WBGene00018997", "P27639", "WBGene00002083", "Q9BL61", "WBGene00022029", "H2L0A8", "WBGene00019157", "O61955", "WBGene00002061", "Q9U302", "WBGene00003902", "A0A486WX07", "WBGene00002066", "Q20935", "WBGene00018997", "P27639", "WBGene00002083", "Q9BL61", "WBGene00022029", "H2L0A8", "WBGene00019157", "O61955", "WBGene00002061", "Q9U302", "WBGene00003902", "P53015", "WBGene00017951", "P34653", "WBGene00014015" ] }, "reaction_10568671": { "compartment": "compartment_70101", "id": "reaction_10568671", "reactome": "R-CEL-8941312", "name": "ZCCHC6, ZCCHC11 are mRNA uridyltransferases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6782337", "species_10523590" ], "products": [ "species_10568627" ], "modifiers": [ [ "species_10568668", "catalyst" ] ], "additional_components": [ "A0A486WX07", "WBGene00002066", "Q20935", "WBGene00018997", "P27639", "WBGene00002083", "Q9BL61", "WBGene00022029", "H2L0A8", "WBGene00019157", "O61955", "WBGene00002061", "Q9U302", "WBGene00003902", "species_6782337", "A0A486WX07", "WBGene00002066", "Q20935", "WBGene00018997", "P27639", "WBGene00002083", "Q9BL61", "WBGene00022029", "H2L0A8", "WBGene00019157", "O61955", "WBGene00002061", "Q9U302", "WBGene00003902", "Q09409", "WBGene00019629", "O02094", "WBGene00194706", "O44768", "WBGene00003499", "Q20377", "WBGene00194706", "G5EFR3", "WBGene00194706", "L8E6M1", "WBGene00194706", "Q09408", "WBGene00019628" ] }, "reaction_10523600": { "compartment": "compartment_70101", "id": "reaction_10523600", "reactome": "R-CEL-429978", "name": "Lsm1-7 Complex binds deadenylated mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10523548", "species_429974" ], "products": [ "species_10523550" ], "modifiers": [], "additional_components": [ "Q95XN6", "WBGene00003080", "P92022", "WBGene00001808", "Q23543", "WBGene00003081", "Q20229", "WBGene00003076", "Q20374", "WBGene00009661", "Q9U1W8", "WBGene00003077", "Q19952", "WBGene00003078", "O18694", "WBGene00003079", "Q95XN6", "WBGene00003080", "P92022", "WBGene00001808", "Q23543", "WBGene00003081", "Q20229", "WBGene00003076", "Q20374", "WBGene00009661", "Q9U1W8", "WBGene00003077", "Q19952", "WBGene00003078", "O18694", "WBGene00003079" ] }, "reaction_10523584": { "compartment": "compartment_70101", "id": "reaction_10523584", "reactome": "R-CEL-429860", "name": "DCP1-DCP2 complex decaps mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10523550", "species_29356" ], "products": [ "species_430004", "species_10523552" ], "modifiers": [ [ "species_10523581", "catalyst" ] ], "additional_components": [ "Q95XN6", "WBGene00003080", "P92022", "WBGene00001808", "Q23543", "WBGene00003081", "Q20229", "WBGene00003076", "Q20374", "WBGene00009661", "Q9U1W8", "WBGene00003077", "Q19952", "WBGene00003078", "O18694", "WBGene00003079", "Q95XN6", "WBGene00003080", "P92022", "WBGene00001808", "Q23543", "WBGene00003081", "Q20229", "WBGene00003076", "Q20374", "WBGene00009661", "Q9U1W8", "WBGene00003077", "Q19952", "WBGene00003078", "O18694", "WBGene00003079", "O62255", "WBGene00003582", "Q21740", "WBGene00011036", "Q8ITV6", "WBGene00021551", "Q9N363", "WBGene00021929", "Q95YF3", "WBGene00000479" ] }, "reaction_10557208": { "compartment": "compartment_70101", "id": "reaction_10557208", "reactome": "R-CEL-5694126", "name": "NT5C3B hydrolyses 7MGP to 7MG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_430042" ], "products": [ "species_29372", "species_5694090" ], "modifiers": [ [ "species_10557205", "catalyst" ] ], "additional_components": [ "WBGene00017775" ] }, "reaction_10523598": { "compartment": "compartment_70101", "id": "reaction_10523598", "reactome": "R-CEL-429961", "name": "DCPS scavenges the 7-methylguanosine cap of mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_429926" ], "products": [ "species_430042", "species_429925" ], "modifiers": [ [ "species_10523595", "catalyst" ] ], "additional_components": [ "WBGene00000940" ] }, "reaction_10523695": { "compartment": "compartment_70101", "id": "reaction_10523695", "reactome": "R-CEL-430028", "name": "Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_429974" ], "products": [ "species_109402", "species_113578", "species_109395", "species_429926", "species_76577" ], "modifiers": [ [ "species_10523692", "catalyst" ] ], "additional_components": [ "Q9BKR2", "WBGene00021613", "A5Z2V7", "WBGene00008533", "Q19103", "WBGene00008502", "Q95XD0", "WBGene00022232", "G5EDS8", "WBGene00009289", "Q95QG7", "WBGene00018305", "Q9N4P9", "WBGene00000202", "G5EG59", "WBGene00000798", "Q17533", "WBGene00007201", "Q20128", "WBGene00018154", "Q9XXD2", "WBGene00012966", "Q17632", "WBGene00001001", "Q93830", "WBGene00010325", "P90922", "WBGene00010622" ] }, "reaction_10567172": { "compartment": "compartment_70101", "id": "reaction_10567172", "reactome": "R-CEL-8874082", "name": "MET phosphorylates PTK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10567169" ], "products": [ "species_29370", "species_10567156" ], "modifiers": [ [ "species_10567169", "catalyst" ] ], "additional_components": [ "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q9XVQ7", "WBGene00008711", "Q95YD4", "WBGene00002213", "Q95YD4", "WBGene00002213", "Q9XVQ7", "WBGene00008711", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q9XVQ7", "WBGene00008711", "Q95YD4", "WBGene00002213" ] }, "reaction_10567165": { "compartment": "compartment_70101", "id": "reaction_10567165", "reactome": "R-CEL-8874080", "name": "SRC phosphorylates PTK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10567156" ], "products": [ "species_10567162", "species_29370" ], "modifiers": [ [ "species_10567156", "catalyst" ] ], "additional_components": [ "Q95YD4", "WBGene00002213", "Q9XVQ7", "WBGene00008711", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q9XVQ7", "WBGene00008711", "Q95YD4", "WBGene00002213", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q95YD4", "WBGene00002213", "Q9XVQ7", "WBGene00008711", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635" ] }, "reaction_10548900": { "compartment": "compartment_876", "id": "reaction_10548900", "reactome": "R-CEL-3965444", "name": "WNT:FZD complex promotes G-protein nucleotide exchange", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10548893" ], "products": [ "species_29420", "species_10548897" ], "modifiers": [ [ "species_10548893", "catalyst" ] ], "additional_components": [ "Q9N532", "WBGene00003238", "G5EDV1", "WBGene00003006", "A0A0K3AWM6", "T23D8.1b", "G5ECQ2", "WBGene00000478", "P51875", "WBGene00001648", "Q21917", "WBGene00001669", "P91907", "WBGene00001677", "Q93743", "WBGene00001668", "Q20907", "WBGene00001670", "O76584", "WBGene00001673", "Q9BIG2", "WBGene00001676", "Q20910", "WBGene00001671", "species_29420", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "Q9N532", "WBGene00003238", "G5EDV1", "WBGene00003006", "A0A0K3AWM6", "T23D8.1b", "G5ECQ2", "WBGene00000478", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "P51875", "WBGene00001648", "Q21917", "WBGene00001669", "P91907", "WBGene00001677", "Q93743", "WBGene00001668", "Q20907", "WBGene00001670", "O76584", "WBGene00001673", "Q9BIG2", "WBGene00001676", "Q20910", "WBGene00001671", "species_29438", "Q9N532", "WBGene00003238", "G5EDV1", "WBGene00003006", "A0A0K3AWM6", "T23D8.1b", "G5ECQ2", "WBGene00000478", "P51875", "WBGene00001648", "Q21917", "WBGene00001669", "P91907", "WBGene00001677", "Q93743", "WBGene00001668", "Q20907", "WBGene00001670", "O76584", "WBGene00001673", "Q9BIG2", "WBGene00001676", "Q20910", "WBGene00001671", "species_29420", "P17343", "WBGene00001679", "P54406", "WBGene00001681" ] }, "reaction_10549076": { "compartment": "compartment_70101", "id": "reaction_10549076", "reactome": "R-CEL-4332358", "name": "Dissociation of CaM and CAMK2 autophosphorylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10549073" ], "products": [ "species_10549071", "species_29370", "species_10508995" ], "modifiers": [ [ "species_10549073", "catalyst" ] ], "additional_components": [ "species_74016", "Q11083", "WBGene00020378", "P04630", "WBGene00000285", "G5EF37", "WBGene00003934", "A0A2C9C3L3", "WBGene00020378", "Q18136", "WBGene00006861", "Q09665", "WBGene00006583", "O02159", "WBGene00020378", "G5EDZ8", "WBGene00000288", "Q94288", "WBGene00000287", "Q09980", "WBGene00017394", "O16305", "WBGene00000552", "G5EEG0", "WBGene00000286", "O62305", "WBGene00006779", "O62305", "WBGene00006779", "species_74016", "Q11083", "WBGene00020378", "P04630", "WBGene00000285", "G5EF37", "WBGene00003934", "A0A2C9C3L3", "WBGene00020378", "Q18136", "WBGene00006861", "Q09665", "WBGene00006583", "O02159", "WBGene00020378", "G5EDZ8", "WBGene00000288", "Q94288", "WBGene00000287", "Q09980", "WBGene00017394", "O16305", "WBGene00000552", "G5EEG0", "WBGene00000286", "species_74016", "Q11083", "WBGene00020378", "P04630", "WBGene00000285", "G5EF37", "WBGene00003934", "A0A2C9C3L3", "WBGene00020378", "Q18136", "WBGene00006861", "Q09665", "WBGene00006583", "O02159", "WBGene00020378", "G5EDZ8", "WBGene00000288", "Q94288", "WBGene00000287", "Q09980", "WBGene00017394", "O16305", "WBGene00000552", "G5EEG0", "WBGene00000286", "O62305", "WBGene00006779" ] }, "reaction_10548902": { "compartment": "compartment_876", "id": "reaction_10548902", "reactome": "R-CEL-3965447", "name": "G-protein subunits dissociate from WNT:FZD complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10548897" ], "products": [ "species_10509165", "species_10548887", "species_10548880" ], "modifiers": [], "additional_components": [ "Q9N532", "WBGene00003238", "G5EDV1", "WBGene00003006", "A0A0K3AWM6", "T23D8.1b", "G5ECQ2", "WBGene00000478", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "P51875", "WBGene00001648", "Q21917", "WBGene00001669", "P91907", "WBGene00001677", "Q93743", "WBGene00001668", "Q20907", "WBGene00001670", "O76584", "WBGene00001673", "Q9BIG2", "WBGene00001676", "Q20910", "WBGene00001671", "species_29438", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "P51875", "WBGene00001648", "Q21917", "WBGene00001669", "P91907", "WBGene00001677", "Q93743", "WBGene00001668", "Q20907", "WBGene00001670", "O76584", "WBGene00001673", "Q9BIG2", "WBGene00001676", "Q20910", "WBGene00001671", "Q9N532", "WBGene00003238", "G5EDV1", "WBGene00003006", "A0A0K3AWM6", "T23D8.1b", "G5ECQ2", "WBGene00000478" ] }, "reaction_10549082": { "compartment": "compartment_70101", "id": "reaction_10549082", "reactome": "R-CEL-4332359", "name": "Active calmodulin binds CAMK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10523903", "species_10508995" ], "products": [ "species_10549078" ], "modifiers": [ [ "species_10549080", "inhibitor" ] ], "additional_components": [ "O62305", "WBGene00006779", "species_74016", "Q11083", "WBGene00020378", "P04630", "WBGene00000285", "G5EF37", "WBGene00003934", "A0A2C9C3L3", "WBGene00020378", "Q18136", "WBGene00006861", "Q09665", "WBGene00006583", "O02159", "WBGene00020378", "G5EDZ8", "WBGene00000288", "Q94288", "WBGene00000287", "Q09980", "WBGene00017394", "O16305", "WBGene00000552", "G5EEG0", "WBGene00000286", "species_74016", "Q11083", "WBGene00020378", "P04630", "WBGene00000285", "G5EF37", "WBGene00003934", "A0A2C9C3L3", "WBGene00020378", "Q18136", "WBGene00006861", "Q09665", "WBGene00006583", "O02159", "WBGene00020378", "G5EDZ8", "WBGene00000288", "Q94288", "WBGene00000287", "Q09980", "WBGene00017394", "O16305", "WBGene00000552", "G5EEG0", "WBGene00000286", "O62305", "WBGene00006779", "species_74016", "Q11083", "WBGene00020378", "P04630", "WBGene00000285", "G5EF37", "WBGene00003934", "A0A2C9C3L3", "WBGene00020378", "Q18136", "WBGene00006861", "Q09665", "WBGene00006583", "O02159", "WBGene00020378", "G5EDZ8", "WBGene00000288", "Q94288", "WBGene00000287", "Q09980", "WBGene00017394", "O16305", "WBGene00000552", "G5EEG0", "WBGene00000286", "P22981", "WBGene00002335" ] }, "reaction_10549228": { "compartment": "compartment_70101", "id": "reaction_10549228", "reactome": "R-CEL-4551465", "name": "Translocation of NFATC1:CaN:CaM to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10549222" ], "products": [ "species_10549226" ], "modifiers": [], "additional_components": [ "species_74016", "Q11083", "WBGene00020378", "P04630", "WBGene00000285", "G5EF37", "WBGene00003934", "A0A2C9C3L3", "WBGene00020378", "Q18136", "WBGene00006861", "Q09665", "WBGene00006583", "O02159", "WBGene00020378", "G5EDZ8", "WBGene00000288", "Q94288", "WBGene00000287", "Q09980", "WBGene00017394", "O16305", "WBGene00000552", "G5EEG0", "WBGene00000286", "species_216785", "Q0G819", "WBGene00006527", "species_912516", "G5EDN6", "WBGene00000554", "species_912516", "Q0G819", "WBGene00006527", "species_216785", "species_74016", "A0A2C9C3L3", "WBGene00020378", "Q09980", "WBGene00017394", "G5EDZ8", "WBGene00000288", "Q11083", "WBGene00020378", "G5EEG0", "WBGene00000286", "Q18136", "WBGene00006861", "G5EF37", "WBGene00003934", "Q94288", "WBGene00000287", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "P04630", "WBGene00000285", "Q09665", "WBGene00006583", "G5EDN6", "WBGene00000554" ] }, "reaction_10545533": { "compartment": "compartment_70101", "id": "reaction_10545533", "reactome": "R-CEL-2730872", "name": "Activation of Calcineurin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10541838", "species_10508995", "species_74016" ], "products": [ "species_10545507" ], "modifiers": [], "additional_components": [ "G5EDN6", "WBGene00000554", "species_216785", "Q0G819", "WBGene00006527", "species_912516", "species_74016", "Q11083", "WBGene00020378", "P04630", "WBGene00000285", "G5EF37", "WBGene00003934", "A0A2C9C3L3", "WBGene00020378", "Q18136", "WBGene00006861", "Q09665", "WBGene00006583", "O02159", "WBGene00020378", "G5EDZ8", "WBGene00000288", "Q94288", "WBGene00000287", "Q09980", "WBGene00017394", "O16305", "WBGene00000552", "G5EEG0", "WBGene00000286", "species_74016", "Q11083", "WBGene00020378", "P04630", "WBGene00000285", "G5EF37", "WBGene00003934", "A0A2C9C3L3", "WBGene00020378", "Q18136", "WBGene00006861", "Q09665", "WBGene00006583", "O02159", "WBGene00020378", "G5EDZ8", "WBGene00000288", "Q94288", "WBGene00000287", "Q09980", "WBGene00017394", "O16305", "WBGene00000552", "G5EEG0", "WBGene00000286", "species_216785", "Q0G819", "WBGene00006527", "species_912516", "G5EDN6", "WBGene00000554" ] }, "reaction_10549086": { "compartment": "compartment_70101", "id": "reaction_10549086", "reactome": "R-CEL-4332363", "name": "Autophosphorylation and activation of CAMK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10549078" ], "products": [ "species_29370", "species_10549073" ], "modifiers": [ [ "species_10549078", "catalyst" ] ], "additional_components": [ "species_74016", "Q11083", "WBGene00020378", "P04630", "WBGene00000285", "G5EF37", "WBGene00003934", "A0A2C9C3L3", "WBGene00020378", "Q18136", "WBGene00006861", "Q09665", "WBGene00006583", "O02159", "WBGene00020378", "G5EDZ8", "WBGene00000288", "Q94288", "WBGene00000287", "Q09980", "WBGene00017394", "O16305", "WBGene00000552", "G5EEG0", "WBGene00000286", "O62305", "WBGene00006779", "species_74016", "Q11083", "WBGene00020378", "P04630", "WBGene00000285", "G5EF37", "WBGene00003934", "A0A2C9C3L3", "WBGene00020378", "Q18136", "WBGene00006861", "Q09665", "WBGene00006583", "O02159", "WBGene00020378", "G5EDZ8", "WBGene00000288", "Q94288", "WBGene00000287", "Q09980", "WBGene00017394", "O16305", "WBGene00000552", "G5EEG0", "WBGene00000286", "O62305", "WBGene00006779", "species_74016", "Q11083", "WBGene00020378", "P04630", "WBGene00000285", "G5EF37", "WBGene00003934", "A0A2C9C3L3", "WBGene00020378", "Q18136", "WBGene00006861", "Q09665", "WBGene00006583", "O02159", "WBGene00020378", "G5EDZ8", "WBGene00000288", "Q94288", "WBGene00000287", "Q09980", "WBGene00017394", "O16305", "WBGene00000552", "G5EEG0", "WBGene00000286", "O62305", "WBGene00006779" ] }, "reaction_10549150": { "compartment": "compartment_7660", "id": "reaction_10549150", "reactome": "R-CEL-4411383", "name": "NLK phosphorylates TCF/LEF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10549137" ], "products": [ "species_113582", "species_10549147" ], "modifiers": [ [ "species_10549133", "catalyst" ] ], "additional_components": [ "Q10666", "WBGene00004077", "O44326", "WBGene00001979", "Q10666", "WBGene00004077", "O44326", "WBGene00001979", "Q9U9Y8", "WBGene00003048" ] }, "reaction_10549135": { "compartment": "compartment_7660", "id": "reaction_10549135", "reactome": "R-CEL-4411373", "name": "NLK translocates to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10549129" ], "products": [ "species_10549133" ], "modifiers": [], "additional_components": [ "Q9U9Y8", "WBGene00003048", "Q9U9Y8", "WBGene00003048" ] }, "reaction_10508197": { "compartment": "compartment_5460", "id": "reaction_10508197", "reactome": "R-CEL-77254", "name": "(S)-3-Hydroxydodecanoyl-CoA+NAD<=>3-Oxododecanoyl-CoA+NADH+H", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113526", "species_77252" ], "products": [ "species_113529", "species_77253", "species_29362" ], "modifiers": [ [ "species_10508194", "catalyst" ] ], "additional_components": [ "P41938", "WBGene00007129" ] }, "reaction_10508199": { "compartment": "compartment_5460", "id": "reaction_10508199", "reactome": "R-CEL-77256", "name": "2-trans-Dodecenoyl-CoA+H2O<=>(S)-3-Hydroxydodecanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77255", "species_113521" ], "products": [ "species_77252" ], "modifiers": [ [ "species_10503463", "catalyst" ] ], "additional_components": [ "P34559", "WBGene00001155" ] }, "reaction_10508238": { "compartment": "compartment_5460", "id": "reaction_10508238", "reactome": "R-CEL-77309", "name": "3-Oxododecanoyl-CoA+CoA-SH<=>Decanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_77253" ], "products": [ "species_77308", "species_113559" ], "modifiers": [ [ "species_10508211", "catalyst" ] ], "additional_components": [ "P34255", "WBGene00015125", "Q9GYT0", "WBGene00020347" ] }, "reaction_10570192": { "compartment": "compartment_161320", "id": "reaction_10570192", "reactome": "R-CEL-8963864", "name": "CUBN dissociates from 25(OH)D", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10570190" ], "products": [ "species_10570188", "species_350136" ], "modifiers": [], "additional_components": [ "Q93212", "WBGene00004944", "species_8963879", "WBGene00004944" ] }, "reaction_10516418": { "compartment": "compartment_70101", "id": "reaction_10516418", "reactome": "R-CEL-209845", "name": "CYP2R1 25-hydroxylates VD3 to 25(OH)D", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29368", "species_8963870", "species_29364" ], "products": [ "species_8963879", "species_29356", "species_29366" ], "modifiers": [ [ "species_10516415", "catalyst" ] ], "additional_components": [ "WBGene00016768" ] }, "reaction_10516354": { "compartment": "compartment_70616", "id": "reaction_10516354", "reactome": "R-CEL-209765", "name": "CYP24A1 hydroxylates 1,25(OH)2D, inactivating it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_209800", "species_29368", "species_29364" ], "products": [ "species_29356", "species_350159", "species_29366" ], "modifiers": [ [ "species_10516351", "catalyst" ], [ "species_29532", "catalyst" ] ], "additional_components": [ "G5EGT6", "WBGene00010354", "O17851", "WBGene00009226", "O45219", "WBGene00007140", "Q09660", "WBGene00000375", "Q9N525", "WBGene00021412", "Q9N574", "WBGene00021200", "Q9XVA6", "WBGene00008499", "G5EC97", "WBGene00011830" ] }, "reaction_10570196": { "compartment": "compartment_7660", "id": "reaction_10570196", "reactome": "R-CEL-8963915", "name": "1,25(OH)2D binds VDR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10519369", "species_8963912" ], "products": [ "species_10570194" ], "modifiers": [], "additional_components": [ "Q94407", "WBGene00003638", "Q9XYB7", "WBGene00003607", "G5EFF5", "WBGene00000908", "species_8963912", "Q94407", "WBGene00003638", "Q9XYB7", "WBGene00003607", "G5EFF5", "WBGene00000908" ] }, "reaction_10551658": { "compartment": "compartment_7660", "id": "reaction_10551658", "reactome": "R-CEL-5358592", "name": "DNA ligase I ligates single stranded nick in double stranded DNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_5358610" ], "products": [ "species_109966", "species_164121", "species_113541" ], "modifiers": [ [ "species_10502732", "catalyst" ] ], "additional_components": [ "WBGene00002985" ] }, "reaction_10544314": { "compartment": "compartment_876", "id": "reaction_10544314", "reactome": "R-CEL-2465890", "name": "DDR2 binds collagen type I, II, III, V, X fibrils", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10544310", "species_10544308" ], "products": [ "species_10544312" ], "modifiers": [], "additional_components": [ "Q9N4U2", "WBGene00000647", "O76368", "WBGene00000674", "Q09457", "WBGene00000251", "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689", "P17140", "WBGene00002280", "Q95ZV7", "WBGene00017381", "Q95ZV7", "WBGene00017381", "Q9N4U2", "WBGene00000647", "O76368", "WBGene00000674", "Q09457", "WBGene00000251", "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689", "P17140", "WBGene00002280" ] }, "reaction_10543934": { "compartment": "compartment_876", "id": "reaction_10543934", "reactome": "R-CEL-2327738", "name": "DDR1 binds collagen type I, II, III, IV, V, XI fibrils", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10543930", "species_10543928" ], "products": [ "species_10543932" ], "modifiers": [], "additional_components": [ "Q9N4U2", "WBGene00000647", "O76368", "WBGene00000674", "Q09457", "WBGene00000251", "P17140", "WBGene00002280", "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689", "Q95ZV7", "WBGene00017381", "Q95ZV7", "WBGene00017381", "Q9N4U2", "WBGene00000647", "O76368", "WBGene00000674", "Q09457", "WBGene00000251", "P17140", "WBGene00002280", "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689" ] }, "reaction_10508096": { "compartment": "compartment_17960", "id": "reaction_10508096", "reactome": "R-CEL-76466", "name": "CYP4A11 12-hydroxylates DDCX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_33549", "species_113601" ], "products": [ "species_113519", "species_113564", "species_42373" ], "modifiers": [ [ "species_10508093", "catalyst" ] ], "additional_components": [ "Q9N525", "WBGene00021412", "O17851", "WBGene00009226", "Q9N574", "WBGene00021200", "O45219", "WBGene00007140", "G5EC97", "WBGene00011830", "Q9XVA6", "WBGene00008499", "Q09660", "WBGene00000375", "G5EGT6", "WBGene00010354" ] }, "reaction_10516947": { "compartment": "compartment_17960", "id": "reaction_10516947", "reactome": "R-CEL-211904", "name": "CYP4F12 18-hydroxylates ARA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_140356", "species_113601" ], "products": [ "species_113519", "species_113564", "species_352318" ], "modifiers": [ [ "species_10516944", "catalyst" ] ], "additional_components": [ "G5EC97", "WBGene00011830", "O17851", "WBGene00009226", "G5EGT6", "WBGene00010354", "O45219", "WBGene00007140", "Q9N574", "WBGene00021200", "Q09660", "WBGene00000375", "Q9N525", "WBGene00021412", "Q9XVA6", "WBGene00008499" ] }, "reaction_10517062": { "compartment": "compartment_17960", "id": "reaction_10517062", "reactome": "R-CEL-211983", "name": "CYP2J2 oxidises ARA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_140356", "species_113601" ], "products": [ "species_113519", "species_113564", "species_215062" ], "modifiers": [ [ "species_10517059", "catalyst" ] ], "additional_components": [ "CHEBI:34130", "CHEBI:34157", "species_2142739", "CHEBI:34490", "O45659", "WBGene00010589", "O61204", "WBGene00015045", "O61935", "WBGene00020386", "O62377", "WBGene00011699", "O62378", "WBGene00011698", "P90771", "WBGene00007913", "Q20315", "WBGene00018333", "A0A0M7RF98", "WBGene00018264", "Q27465", "WBGene00015135", "G5ECD0", "WBGene00007362", "Q27470", "WBGene00015709", "G5EE22", "WBGene00012448", "Q27471", "WBGene00016092", "H2KY69", "WBGene00015044", "Q27482", "WBGene00016768", "H2KYS3", "WBGene00000905", "Q27499", "WBGene00018334", "O02627", "WBGene00015399", "Q965T7", "WBGene00021710", "O02628", "WBGene00015400", "Q9N4Q4", "WBGene00021168", "O02641", "WBGene00019967", "Q9N5I1", "WBGene00019565", "O16220", "WBGene00016786", "O16362", "WBGene00018413", "O16482", "WBGene00016860", "O16670", "WBGene00018262", "O16671", "WBGene00018261", "O16673", "WBGene00018260", "O44649", "WBGene00019473", "O44650", "WBGene00019472", "O44651", "WBGene00019471", "O44652", "WBGene00019470", "O44655", "WBGene00015040", "O44656", "WBGene00015041", "O44657", "WBGene00015042", "O44658", "WBGene00015043", "O44704", "WBGene00016686", "O44706", "WBGene00016697", "O45364", "WBGene00008829" ] }, "reaction_10516957": { "compartment": "compartment_17960", "id": "reaction_10516957", "reactome": "R-CEL-211924", "name": "CYP4B1 12-hydroxylates ARA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_140356", "species_113601" ], "products": [ "species_113519", "species_113564", "species_215075" ], "modifiers": [ [ "species_10516954", "catalyst" ] ], "additional_components": [ "G5EC97", "WBGene00011830", "G5EGT6", "WBGene00010354", "O17851", "WBGene00009226", "O45219", "WBGene00007140", "Q09660", "WBGene00000375", "Q9N525", "WBGene00021412", "Q9N574", "WBGene00021200", "Q9XVA6", "WBGene00008499" ] }, "reaction_10558194": { "compartment": "compartment_12045", "id": "reaction_10558194", "reactome": "R-CEL-6786239", "name": "CYP4V2 omega-hydroxylates DHA to HDoHE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_6786220", "species_29368", "species_29364" ], "products": [ "species_29356", "species_29366", "species_6786225" ], "modifiers": [ [ "species_10558191", "catalyst" ] ], "additional_components": [ "WBGene00013585" ] }, "reaction_10513355": { "compartment": "compartment_70101", "id": "reaction_10513355", "reactome": "R-CEL-193060", "name": "CYP19A1 hydroxylates ANDST to E1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29368", "species_193079", "species_29364" ], "products": [ "species_29356", "species_193066", "species_29366", "species_29460" ], "modifiers": [ [ "species_10513352", "catalyst" ] ], "additional_components": [ "Q09660", "WBGene00000375", "Q9N525", "WBGene00021412", "Q9N574", "WBGene00021200", "Q9XVA6", "WBGene00008499", "G5EC97", "WBGene00011830", "G5EGT6", "WBGene00010354", "O17851", "WBGene00009226", "O45219", "WBGene00007140" ] }, "reaction_10516928": { "compartment": "compartment_12045", "id": "reaction_10516928", "reactome": "R-CEL-211873", "name": "CYP4F2, 4F3 20-hydroxylate LTB4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_266056", "species_70106", "species_29368", "species_29364" ], "products": [ "species_29356", "species_29366", "species_2161636" ], "modifiers": [ [ "species_10516925", "catalyst" ] ], "additional_components": [ "Q9XVA6", "WBGene00008499", "G5EC97", "WBGene00011830", "G5EGT6", "WBGene00010354", "O17851", "WBGene00009226", "O45219", "WBGene00007140", "Q09660", "WBGene00000375", "Q9N525", "WBGene00021412", "Q9N574", "WBGene00021200" ] }, "reaction_10552597": { "compartment": "compartment_12045", "id": "reaction_10552597", "reactome": "R-CEL-5602295", "name": "CYP4F22 20-hydroxylates TrXA3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_2142713", "species_29368", "species_29364" ], "products": [ "species_5602281", "species_29356", "species_29366" ], "modifiers": [ [ "species_10508091", "catalyst" ] ], "additional_components": [ "O45219", "WBGene00007140", "Q09660", "WBGene00000375", "Q9N525", "WBGene00021412", "Q9N574", "WBGene00021200", "Q9XVA6", "WBGene00008499", "G5EC97", "WBGene00011830", "G5EGT6", "WBGene00010354", "O17851", "WBGene00009226" ] }, "reaction_10516952": { "compartment": "compartment_17960", "id": "reaction_10516952", "reactome": "R-CEL-211919", "name": "CYP4F8 19-hydroxylates PGH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_30138", "species_113601" ], "products": [ "species_113519", "species_113564", "species_215545" ], "modifiers": [ [ "species_10516949", "catalyst" ] ], "additional_components": [ "Q9XVA6", "WBGene00008499", "G5EC97", "WBGene00011830", "G5EGT6", "WBGene00010354", "O17851", "WBGene00009226", "O45219", "WBGene00007140", "Q09660", "WBGene00000375", "Q9N525", "WBGene00021412", "Q9N574", "WBGene00021200" ] }, "reaction_10517164": { "compartment": "compartment_17960", "id": "reaction_10517164", "reactome": "R-CEL-215526", "name": "CYP4F3 20-hydroxylates LTB4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_215557", "species_113601" ], "products": [ "species_113519", "species_113564", "species_571314" ], "modifiers": [ [ "species_10516925", "catalyst" ] ], "additional_components": [ "Q9XVA6", "WBGene00008499", "G5EC97", "WBGene00011830", "G5EGT6", "WBGene00010354", "O17851", "WBGene00009226", "O45219", "WBGene00007140", "Q09660", "WBGene00000375", "Q9N525", "WBGene00021412", "Q9N574", "WBGene00021200" ] }, "reaction_10516959": { "compartment": "compartment_5460", "id": "reaction_10516959", "reactome": "R-CEL-211950", "name": "CYP24A1 24-hydroxylates CTL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113533", "species_113529", "species_215607", "species_113600" ], "products": [ "species_113563", "species_215622", "species_113521" ], "modifiers": [ [ "species_10516351", "catalyst" ] ], "additional_components": [ "G5EGT6", "WBGene00010354", "O17851", "WBGene00009226", "O45219", "WBGene00007140", "Q09660", "WBGene00000375", "Q9N525", "WBGene00021412", "Q9N574", "WBGene00021200", "Q9XVA6", "WBGene00008499", "G5EC97", "WBGene00011830" ] }, "reaction_10507989": { "compartment": "compartment_12045", "id": "reaction_10507989", "reactome": "R-CEL-76456", "name": "O-atom dealkylation of dextromethorphan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_39703", "species_113601" ], "products": [ "species_143501", "species_113519", "species_113564", "species_76455" ], "modifiers": [ [ "species_10507986", "catalyst" ] ], "additional_components": [ "Q965T7", "WBGene00021710", "O16671", "WBGene00018261", "O45659", "WBGene00010589", "Q9N4Q4", "WBGene00021168", "A0A0M7RF98", "WBGene00018264", "O16673", "WBGene00018260", "O61204", "WBGene00015045", "Q9N5I1", "WBGene00019565", "G5ECD0", "WBGene00007362", "O44649", "WBGene00019473", "O61935", "WBGene00020386", "G5EE22", "WBGene00012448", "O44650", "WBGene00019472", "O62377", "WBGene00011699", "H2KY69", "WBGene00015044", "O44651", "WBGene00019471", "O62378", "WBGene00011698", "H2KYS3", "WBGene00000905", "O44652", "WBGene00019470", "P90771", "WBGene00007913", "O02627", "WBGene00015399", "O44655", "WBGene00015040", "Q20315", "WBGene00018333", "O02628", "WBGene00015400", "O44656", "WBGene00015041", "Q27465", "WBGene00015135", "O02641", "WBGene00019967", "O44657", "WBGene00015042", "Q27470", "WBGene00015709", "O16220", "WBGene00016786", "O44658", "WBGene00015043", "Q27471", "WBGene00016092", "O16362", "WBGene00018413", "O44704", "WBGene00016686", "Q27482", "WBGene00016768", "O16482", "WBGene00016860", "O44706", "WBGene00016697", "Q27499", "WBGene00018334", "O16670", "WBGene00018262", "O45364", "WBGene00008829" ] }, "reaction_10517052": { "compartment": "compartment_12045", "id": "reaction_10517052", "reactome": "R-CEL-211966", "name": "CYP2D6 4-hydroxylates debrisoquine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_211993", "species_113601" ], "products": [ "species_113519", "species_113564", "species_211952" ], "modifiers": [ [ "species_10507986", "catalyst" ] ], "additional_components": [ "Q965T7", "WBGene00021710", "O16671", "WBGene00018261", "O45659", "WBGene00010589", "Q9N4Q4", "WBGene00021168", "A0A0M7RF98", "WBGene00018264", "O16673", "WBGene00018260", "O61204", "WBGene00015045", "Q9N5I1", "WBGene00019565", "G5ECD0", "WBGene00007362", "O44649", "WBGene00019473", "O61935", "WBGene00020386", "G5EE22", "WBGene00012448", "O44650", "WBGene00019472", "O62377", "WBGene00011699", "H2KY69", "WBGene00015044", "O44651", "WBGene00019471", "O62378", "WBGene00011698", "H2KYS3", "WBGene00000905", "O44652", "WBGene00019470", "P90771", "WBGene00007913", "O02627", "WBGene00015399", "O44655", "WBGene00015040", "Q20315", "WBGene00018333", "O02628", "WBGene00015400", "O44656", "WBGene00015041", "Q27465", "WBGene00015135", "O02641", "WBGene00019967", "O44657", "WBGene00015042", "Q27470", "WBGene00015709", "O16220", "WBGene00016786", "O44658", "WBGene00015043", "Q27471", "WBGene00016092", "O16362", "WBGene00018413", "O44704", "WBGene00016686", "Q27482", "WBGene00016768", "O16482", "WBGene00016860", "O44706", "WBGene00016697", "Q27499", "WBGene00018334", "O16670", "WBGene00018262", "O45364", "WBGene00008829" ] }, "reaction_10517057": { "compartment": "compartment_17960", "id": "reaction_10517057", "reactome": "R-CEL-211968", "name": "CYP2W1 oxidises INDOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_113601", "species_216547" ], "products": [ "species_113519", "species_113564", "species_216598" ], "modifiers": [ [ "species_10517054", "catalyst" ] ], "additional_components": [ "O44651", "WBGene00019471", "O44652", "WBGene00019470", "O44655", "WBGene00015040", "O44656", "WBGene00015041", "O44657", "WBGene00015042", "O44658", "WBGene00015043", "O44704", "WBGene00016686", "O44706", "WBGene00016697", "O45364", "WBGene00008829", "O45659", "WBGene00010589", "O61204", "WBGene00015045", "O61935", "WBGene00020386", "O62377", "WBGene00011699", "O62378", "WBGene00011698", "P90771", "WBGene00007913", "Q20315", "WBGene00018333", "A0A0M7RF98", "WBGene00018264", "Q27465", "WBGene00015135", "G5ECD0", "WBGene00007362", "Q27470", "WBGene00015709", "G5EE22", "WBGene00012448", "Q27471", "WBGene00016092", "H2KY69", "WBGene00015044", "Q27482", "WBGene00016768", "H2KYS3", "WBGene00000905", "Q27499", "WBGene00018334", "O02627", "WBGene00015399", "Q965T7", "WBGene00021710", "O02628", "WBGene00015400", "Q9N4Q4", "WBGene00021168", "O02641", "WBGene00019967", "Q9N5I1", "WBGene00019565", "O16220", "WBGene00016786", "O16362", "WBGene00018413", "O16482", "WBGene00016860", "O16670", "WBGene00018262", "O16671", "WBGene00018261", "O16673", "WBGene00018260", "O44649", "WBGene00019473", "O44650", "WBGene00019472" ] }, "reaction_10517044": { "compartment": "compartment_17960", "id": "reaction_10517044", "reactome": "R-CEL-211960", "name": "CYP2U1 19-hydroxylates ARA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_140356", "species_113601" ], "products": [ "species_216620", "species_113519", "species_113564" ], "modifiers": [ [ "species_10517041", "catalyst" ] ], "additional_components": [ "A0A0M7RF98", "WBGene00018264", "Q27465", "WBGene00015135", "G5ECD0", "WBGene00007362", "Q27470", "WBGene00015709", "G5EE22", "WBGene00012448", "Q27471", "WBGene00016092", "H2KY69", "WBGene00015044", "Q27482", "WBGene00016768", "H2KYS3", "WBGene00000905", "Q27499", "WBGene00018334", "O02627", "WBGene00015399", "Q965T7", "WBGene00021710", "O02628", "WBGene00015400", "Q9N4Q4", "WBGene00021168", "O02641", "WBGene00019967", "Q9N5I1", "WBGene00019565", "O16220", "WBGene00016786", "O16362", "WBGene00018413", "O16482", "WBGene00016860", "O16670", "WBGene00018262", "O16671", "WBGene00018261", "O16673", "WBGene00018260", "O44649", "WBGene00019473", "O44650", "WBGene00019472", "O44651", "WBGene00019471", "O44652", "WBGene00019470", "O44655", "WBGene00015040", "O44656", "WBGene00015041", "O44657", "WBGene00015042", "O44658", "WBGene00015043", "O44704", "WBGene00016686", "O44706", "WBGene00016697", "O45364", "WBGene00008829", "O45659", "WBGene00010589", "O61204", "WBGene00015045", "O61935", "WBGene00020386", "O62377", "WBGene00011699", "O62378", "WBGene00011698", "P90771", "WBGene00007913", "Q20315", "WBGene00018333" ] }, "reaction_10517049": { "compartment": "compartment_17960", "id": "reaction_10517049", "reactome": "R-CEL-211962", "name": "CYP4F11 16-hydroxylates 3OH-PALM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_216621", "species_113601" ], "products": [ "species_113519", "species_113564", "species_216612" ], "modifiers": [ [ "species_10517046", "catalyst" ] ], "additional_components": [ "G5EGT6", "WBGene00010354", "Q9N574", "WBGene00021200" ] }, "reaction_10545531": { "compartment": "compartment_70101", "id": "reaction_10545531", "reactome": "R-CEL-2730867", "name": "Translocation of CaN:CaM:NFAT to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10545511" ], "products": [ "species_10545529" ], "modifiers": [], "additional_components": [ "species_74016", "Q11083", "WBGene00020378", "P04630", "WBGene00000285", "G5EF37", "WBGene00003934", "A0A2C9C3L3", "WBGene00020378", "Q18136", "WBGene00006861", "Q09665", "WBGene00006583", "O02159", "WBGene00020378", "G5EDZ8", "WBGene00000288", "Q94288", "WBGene00000287", "Q09980", "WBGene00017394", "O16305", "WBGene00000552", "G5EEG0", "WBGene00000286", "species_216785", "Q0G819", "WBGene00006527", "species_912516", "G5EDN6", "WBGene00000554", "species_912516", "Q0G819", "WBGene00006527", "species_216785", "species_74016", "A0A2C9C3L3", "WBGene00020378", "Q09980", "WBGene00017394", "G5EDZ8", "WBGene00000288", "Q11083", "WBGene00020378", "G5EEG0", "WBGene00000286", "Q18136", "WBGene00006861", "G5EF37", "WBGene00003934", "Q94288", "WBGene00000287", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "P04630", "WBGene00000285", "Q09665", "WBGene00006583", "G5EDN6", "WBGene00000554" ] }, "reaction_10544706": { "compartment": "compartment_2514888", "id": "reaction_10544706", "reactome": "R-CEL-2485182", "name": "Gt-GTP dissociates to GNAT1-GTP and GNB1:GNGT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10544704" ], "products": [ "species_10544702", "species_10544695" ], "modifiers": [], "additional_components": [ "Q9BIG2", "WBGene00001676", "P91907", "WBGene00001677", "Q20907", "WBGene00001670", "Q20910", "WBGene00001671", "Q21917", "WBGene00001669", "Q93743", "WBGene00001668", "O76584", "WBGene00001673", "species_29438", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "Q9BIG2", "WBGene00001676", "P91907", "WBGene00001677", "Q20907", "WBGene00001670", "Q20910", "WBGene00001671", "Q21917", "WBGene00001669", "Q93743", "WBGene00001668", "O76584", "WBGene00001673", "species_29438" ] }, "reaction_10544724": { "compartment": "compartment_70101", "id": "reaction_10544724", "reactome": "R-CEL-2514865", "name": "cGMP dissociates from CNG channels", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10506568" ], "products": [ "species_30991", "species_10506566" ], "modifiers": [], "additional_components": [ "G5EEE2", "WBGene00006525", "Q03611", "WBGene00006526", "Q7Z205", "WBGene00000563", "A8WI01", "WBGene00000562", "Q9N4C1", "WBGene00022295", "O61827", "WBGene00000487", "species_30991", "G5EEE2", "WBGene00006525", "Q03611", "WBGene00006526", "Q7Z205", "WBGene00000563", "A8WI01", "WBGene00000562", "Q9N4C1", "WBGene00022295", "O61827", "WBGene00000487" ] }, "reaction_10544727": { "compartment": "compartment_70101", "id": "reaction_10544727", "reactome": "R-CEL-2514867", "name": "cGMP:CNG transports Na+ and Ca2+ into the rod outer segment", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74112", "species_74113" ], "products": [ "species_83910", "species_74016" ], "modifiers": [ [ "species_10506568", "catalyst" ] ], "additional_components": [ "G5EEE2", "WBGene00006525", "Q03611", "WBGene00006526", "Q7Z205", "WBGene00000563", "A8WI01", "WBGene00000562", "Q9N4C1", "WBGene00022295", "O61827", "WBGene00000487", "species_30991" ] }, "reaction_10544802": { "compartment": "compartment_70101", "id": "reaction_10544802", "reactome": "R-CEL-2534087", "name": "NMT1/2 transfer MYS to GNAT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10544792", "species_2534019" ], "products": [ "species_10544691", "species_76194" ], "modifiers": [ [ "species_10544797", "catalyst" ] ], "additional_components": [ "Q20910", "WBGene00001671", "Q21917", "WBGene00001669", "Q93743", "WBGene00001668", "Q9BIG2", "WBGene00001676", "O76584", "WBGene00001673", "P91907", "WBGene00001677", "Q20907", "WBGene00001670", "Q9BIG2", "WBGene00001676", "P91907", "WBGene00001677", "Q20907", "WBGene00001670", "Q20910", "WBGene00001671", "Q21917", "WBGene00001669", "Q93743", "WBGene00001668", "O76584", "WBGene00001673", "WBGene00020549" ] }, "reaction_10544837": { "compartment": "compartment_70101", "id": "reaction_10544837", "reactome": "R-CEL-2534096", "name": "METAP1/2 demethylates GNAT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10544818" ], "products": [ "species_10544792", "species_174390" ], "modifiers": [ [ "species_10544834", "catalyst" ] ], "additional_components": [ "Q9BIG2", "WBGene00001676", "O76584", "WBGene00001673", "P91907", "WBGene00001677", "Q20907", "WBGene00001670", "Q20910", "WBGene00001671", "Q21917", "WBGene00001669", "Q93743", "WBGene00001668", "Q20910", "WBGene00001671", "Q21917", "WBGene00001669", "Q93743", "WBGene00001668", "Q9BIG2", "WBGene00001676", "O76584", "WBGene00001673", "P91907", "WBGene00001677", "Q20907", "WBGene00001670", "species_880069", "H1UBK1", "WBGene00003130", "Q965Y1", "WBGene00003129" ] }, "reaction_10544774": { "compartment": "compartment_2514888", "id": "reaction_10544774", "reactome": "R-CEL-2530501", "name": "FNTA:FNTB transfers FARN to GNGT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10544764", "species_2530486" ], "products": [ "species_111294", "species_10544700" ], "modifiers": [ [ "species_10544771", "catalyst" ] ], "additional_components": [ "WBGene00001681", "WBGene00001681", "Q19752", "WBGene00006465", "O44501", "WBGene00019823" ] }, "reaction_10544918": { "compartment": "compartment_70101", "id": "reaction_10544918", "reactome": "R-CEL-2586748", "name": "GUCA binds Ca2+ to form GUCA:Ca2+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10544904", "species_74016" ], "products": [ "species_10544916" ], "modifiers": [], "additional_components": [ "WBGene00003564", "species_74016", "P36609", "WBGene00003564" ] }, "reaction_10546711": { "compartment": "compartment_70101", "id": "reaction_10546711", "reactome": "R-CEL-3229181", "name": "CALM1:Ca2+ binds CNG channel", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10506566", "species_10508995" ], "products": [ "species_10546709" ], "modifiers": [ [ "species_74016", "catalyst" ] ], "additional_components": [ "G5EEE2", "WBGene00006525", "Q03611", "WBGene00006526", "Q7Z205", "WBGene00000563", "A8WI01", "WBGene00000562", "Q9N4C1", "WBGene00022295", "O61827", "WBGene00000487", "species_74016", "Q11083", "WBGene00020378", "P04630", "WBGene00000285", "G5EF37", "WBGene00003934", "A0A2C9C3L3", "WBGene00020378", "Q18136", "WBGene00006861", "Q09665", "WBGene00006583", "O02159", "WBGene00020378", "G5EDZ8", "WBGene00000288", "Q94288", "WBGene00000287", "Q09980", "WBGene00017394", "O16305", "WBGene00000552", "G5EEG0", "WBGene00000286", "species_74016", "Q11083", "WBGene00020378", "P04630", "WBGene00000285", "G5EF37", "WBGene00003934", "A0A2C9C3L3", "WBGene00020378", "Q18136", "WBGene00006861", "Q09665", "WBGene00006583", "O02159", "WBGene00020378", "G5EDZ8", "WBGene00000288", "Q94288", "WBGene00000287", "Q09980", "WBGene00017394", "O16305", "WBGene00000552", "G5EEG0", "WBGene00000286", "G5EEE2", "WBGene00006525", "Q03611", "WBGene00006526", "Q7Z205", "WBGene00000563", "A8WI01", "WBGene00000562", "Q9N4C1", "WBGene00022295", "O61827", "WBGene00000487" ] }, "reaction_10506570": { "compartment": "compartment_70101", "id": "reaction_10506570", "reactome": "R-CEL-74031", "name": "cGMP binds CNG channel to form cGMP:CNG channel", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30991", "species_10506566" ], "products": [ "species_10506568" ], "modifiers": [], "additional_components": [ "G5EEE2", "WBGene00006525", "Q03611", "WBGene00006526", "Q7Z205", "WBGene00000563", "A8WI01", "WBGene00000562", "Q9N4C1", "WBGene00022295", "O61827", "WBGene00000487", "G5EEE2", "WBGene00006525", "Q03611", "WBGene00006526", "Q7Z205", "WBGene00000563", "A8WI01", "WBGene00000562", "Q9N4C1", "WBGene00022295", "O61827", "WBGene00000487", "species_30991" ] }, "reaction_10544161": { "compartment": "compartment_70101", "id": "reaction_10544161", "reactome": "R-CEL-2404142", "name": "atROL binds RBP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2473616", "species_10506914" ], "products": [ "species_10544159" ], "modifiers": [], "additional_components": [ "O02324", "WBGene00002260", "O01812", "WBGene00002258", "O01814", "WBGene00002257", "O02323", "WBGene00002259", "O02324", "WBGene00002260", "O01812", "WBGene00002258", "O01814", "WBGene00002257", "O02323", "WBGene00002259", "species_5623649" ] }, "reaction_10544130": { "compartment": "compartment_70101", "id": "reaction_10544130", "reactome": "R-CEL-2399913", "name": "atRAL binds to RBP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10530542", "species_975622" ], "products": [ "species_10530546" ], "modifiers": [], "additional_components": [ "O01812", "WBGene00002258", "O01814", "WBGene00002257", "O02323", "WBGene00002259", "O02324", "WBGene00002260", "species_5623648", "O01812", "WBGene00002258", "O01814", "WBGene00002257", "O02323", "WBGene00002259", "O02324", "WBGene00002260" ] }, "reaction_10530532": { "compartment": "compartment_984", "id": "reaction_10530532", "reactome": "R-CEL-975594", "name": "PLB1 hydrolyses RPALM to atROL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_975591" ], "products": [ "species_975590", "species_426576" ], "modifiers": [ [ "species_10530529", "catalyst" ] ], "additional_components": [ "Q8MXQ8", "WBGene00022256", "Q9N2Z4", "WBGene00022256" ] }, "reaction_10530548": { "compartment": "compartment_70101", "id": "reaction_10530548", "reactome": "R-CEL-975633", "name": "atROL binds to RBP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10530542", "species_975590" ], "products": [ "species_10530544" ], "modifiers": [], "additional_components": [ "O01812", "WBGene00002258", "O01814", "WBGene00002257", "O02323", "WBGene00002259", "O02324", "WBGene00002260", "species_5623649", "O01812", "WBGene00002258", "O01814", "WBGene00002257", "O02323", "WBGene00002259", "O02324", "WBGene00002260" ] }, "reaction_10544165": { "compartment": "compartment_70101", "id": "reaction_10544165", "reactome": "R-CEL-2404144", "name": "Parenchymal atROL translocates to HSCs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10544163" ], "products": [ "species_2473616", "species_10506914" ], "modifiers": [], "additional_components": [ "O02324", "WBGene00002260", "O01812", "WBGene00002258", "O01814", "WBGene00002257", "O02323", "WBGene00002259", "species_5623649", "O02324", "WBGene00002260", "O01812", "WBGene00002258", "O01814", "WBGene00002257", "O02323", "WBGene00002259" ] }, "reaction_10530570": { "compartment": "compartment_70101", "id": "reaction_10530570", "reactome": "R-CEL-975635", "name": "BCMO1:Fe2+ cleaves betaC to atRAL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_975643" ], "products": [ "species_975622" ], "modifiers": [ [ "species_10530567", "catalyst" ] ], "additional_components": [ "Q9U2E4", "WBGene00012914", "H2L060", "WBGene00018640", "Q9TXT9", "WBGene00018755", "species_113531" ] }, "reaction_10545931": { "compartment": "compartment_70101", "id": "reaction_10545931", "reactome": "R-CEL-2855252", "name": "AKRs reduce RBP2:atRAL to RBP2:atROL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_10530546" ], "products": [ "species_29366", "species_10530544" ], "modifiers": [ [ "species_10545928", "catalyst" ] ], "additional_components": [ "species_5623648", "O01812", "WBGene00002258", "O01814", "WBGene00002257", "O02323", "WBGene00002259", "O02324", "WBGene00002260", "species_5623649", "O01812", "WBGene00002258", "O01814", "WBGene00002257", "O02323", "WBGene00002259", "O02324", "WBGene00002260", "P91020", "WBGene00016985", "Q18903", "WBGene00016985", "Q23320", "WBGene00016985" ] }, "reaction_10544155": { "compartment": "compartment_984", "id": "reaction_10544155", "reactome": "R-CEL-2404134", "name": "RBP4:atROL binds TTR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10544137", "species_10544151" ], "products": [ "species_10544153" ], "modifiers": [], "additional_components": [ "species_5623649", "G5EEB8", "WBGene00011726", "Q21882", "WBGene00022808", "O44578", "WBGene00022808", "Q21882", "WBGene00022808", "O44578", "WBGene00022808", "species_5623649", "G5EEB8", "WBGene00011726" ] }, "reaction_10545933": { "compartment": "compartment_70101", "id": "reaction_10545933", "reactome": "R-CEL-2855259", "name": "atROL binds RBP1 (parenchymal cell)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2473610", "species_10506914" ], "products": [ "species_10544163" ], "modifiers": [], "additional_components": [ "O02324", "WBGene00002260", "O01812", "WBGene00002258", "O01814", "WBGene00002257", "O02323", "WBGene00002259", "O02324", "WBGene00002260", "O01812", "WBGene00002258", "O01814", "WBGene00002257", "O02323", "WBGene00002259", "species_5623649" ] }, "reaction_10544157": { "compartment": "compartment_984", "id": "reaction_10544157", "reactome": "R-CEL-2404135", "name": "RBP4 binds atROL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10544135", "species_2395761" ], "products": [ "species_10544137" ], "modifiers": [], "additional_components": [ "WBGene00011726", "species_5623649", "G5EEB8", "WBGene00011726" ] }, "reaction_10550030": { "compartment": "compartment_5460", "id": "reaction_10550030", "reactome": "R-CEL-5164399", "name": "BCO2:Fe2+ cleaves betaC to APO10al and bION", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113533", "species_5164389" ], "products": [ "species_5164390", "species_5164383" ], "modifiers": [ [ "species_10550027", "catalyst" ] ], "additional_components": [ "Q9TXT9", "WBGene00018755", "species_113531" ] }, "reaction_10544304": { "compartment": "compartment_70101", "id": "reaction_10544304", "reactome": "R-CEL-2464822", "name": "RDH12 reduces atRAL to atROL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_975622", "species_29364" ], "products": [ "species_2473615", "species_29366" ], "modifiers": [ [ "species_10544301", "catalyst" ] ], "additional_components": [ "WBGene00007780" ] }, "reaction_10506918": { "compartment": "compartment_70101", "id": "reaction_10506918", "reactome": "R-CEL-74843", "name": "atROL binds RBP1 to form RBP1:atROL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10506914", "species_2473604" ], "products": [ "species_10506916" ], "modifiers": [], "additional_components": [ "O02324", "WBGene00002260", "O01812", "WBGene00002258", "O01814", "WBGene00002257", "O02323", "WBGene00002259", "species_5623649", "O02324", "WBGene00002260", "O01812", "WBGene00002258", "O01814", "WBGene00002257", "O02323", "WBGene00002259" ] }, "reaction_10544295": { "compartment": "compartment_70101", "id": "reaction_10544295", "reactome": "R-CEL-2453833", "name": "RPE65 isomero-hydrolyses atREs to 11cROL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_2864099" ], "products": [ "species_30927", "species_2864103", "species_70106" ], "modifiers": [ [ "species_10544287", "catalyst" ], [ "species_10544293", "catalyst" ] ], "additional_components": [ "CHEBI:70762", "species_2534407", "CHEBI:70760", "CHEBI:70761", "CHEBI:16196", "CHEBI:17351", "species_390435", "species_8934421", "H2L060", "WBGene00018640", "Q9TXT9", "WBGene00018755", "Q9U2E4", "WBGene00012914", "WBGene00002039" ] }, "reaction_10544339": { "compartment": "compartment_70101", "id": "reaction_10544339", "reactome": "R-CEL-2465940", "name": "atRAL is reduced to atROL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_975622", "species_29364" ], "products": [ "species_29366", "species_2473607" ], "modifiers": [ [ "species_10544336", "catalyst" ] ], "additional_components": [ "O18030", "WBGene00000968", "Q19843", "WBGene00000992", "Q22392", "WBGene00000982", "A5JYX5", "WBGene00000967" ] }, "reaction_10543792": { "compartment": "compartment_7660", "id": "reaction_10543792", "reactome": "R-CEL-2294600", "name": "CDK1 phosphorylates condensin II subunit NCAPD3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10543756" ], "products": [ "species_113582", "species_10543788" ], "modifiers": [ [ "species_10511241", "catalyst" ] ], "additional_components": [ "P62784", "WBGene00001875", "Q20818", "WBGene00010093", "Q09591", "WBGene00003367", "P34341", "WBGene00016202", "Q20060", "WBGene00004874", "Q95Y84", "WBGene00001833", "Q20818", "WBGene00010093", "Q09591", "WBGene00003367", "Q95Y84", "WBGene00001833", "P34341", "WBGene00016202", "Q20060", "WBGene00004874", "P62784", "WBGene00001875", "O45926", "WBGene00000866", "Q10653", "WBGene00000865", "Q9BLB5", "WBGene00000867", "P34556", "WBGene00000405" ] }, "reaction_10543762": { "compartment": "compartment_7660", "id": "reaction_10543762", "reactome": "R-CEL-2288097", "name": "Condensin II complex binds H4K20me1-containing nucleosomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10543339", "species_10543368" ], "products": [ "species_10543756" ], "modifiers": [ [ "species_10543760", "catalyst" ] ], "additional_components": [ "Q20818", "WBGene00010093", "Q09591", "WBGene00003367", "P34341", "WBGene00016202", "Q20060", "WBGene00004874", "Q95Y84", "WBGene00001833", "P62784", "WBGene00001875", "P62784", "WBGene00001875", "Q20818", "WBGene00010093", "Q09591", "WBGene00003367", "P34341", "WBGene00016202", "Q20060", "WBGene00004874", "Q95Y84", "WBGene00001833", "Q20818", "WBGene00010093", "Q09591", "WBGene00003367", "P34341", "WBGene00016202", "Q20060", "WBGene00004874", "Q95Y84", "WBGene00001833" ] }, "reaction_10543715": { "compartment": "compartment_7660", "id": "reaction_10543715", "reactome": "R-CEL-2245218", "name": "CDK1 phosphorylates PHF8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10543378" ], "products": [ "species_113582", "species_10543368", "species_10543713" ], "modifiers": [ [ "species_10511241", "catalyst" ] ], "additional_components": [ "species_113531", "Q9GYI0", "WBGene00017920", "P62784", "WBGene00001875", "P62784", "WBGene00001875", "species_113531", "Q9GYI0", "WBGene00017920", "O45926", "WBGene00000866", "Q10653", "WBGene00000865", "Q9BLB5", "WBGene00000867", "P34556", "WBGene00000405" ] }, "reaction_10543385": { "compartment": "compartment_7660", "id": "reaction_10543385", "reactome": "R-CEL-2172678", "name": "PHF8 demethylates histone H4K20me1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113671", "species_113685", "species_10543378" ], "products": [ "species_29478", "species_10543382", "species_159942", "species_159939" ], "modifiers": [ [ "species_10543378", "catalyst" ] ], "additional_components": [ "species_113531", "Q9GYI0", "WBGene00017920", "P62784", "WBGene00001875", "species_113531", "Q9GYI0", "WBGene00017920", "P62784", "WBGene00001875", "species_113531", "Q9GYI0", "WBGene00017920", "P62784", "WBGene00001875" ] }, "reaction_10543786": { "compartment": "compartment_7660", "id": "reaction_10543786", "reactome": "R-CEL-2294580", "name": "PLK1 hyperphosphorylates Condensin II complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10543770" ], "products": [ "species_113582", "species_10543783" ], "modifiers": [ [ "species_10543770", "catalyst" ] ], "additional_components": [ "P62784", "WBGene00001875", "Q20818", "WBGene00010093", "Q09591", "WBGene00003367", "Q95Y84", "WBGene00001833", "P34341", "WBGene00016202", "Q20060", "WBGene00004874", "Q9N2L7", "WBGene00004043", "Q20818", "WBGene00010093", "P34341", "WBGene00016202", "Q09591", "WBGene00003367", "Q20060", "WBGene00004874", "Q95Y84", "WBGene00001833", "P62784", "WBGene00001875", "Q9N2L7", "WBGene00004043", "P62784", "WBGene00001875", "Q20818", "WBGene00010093", "Q09591", "WBGene00003367", "Q95Y84", "WBGene00001833", "P34341", "WBGene00016202", "Q20060", "WBGene00004874", "Q9N2L7", "WBGene00004043" ] }, "reaction_10543804": { "compartment": "compartment_7660", "id": "reaction_10543804", "reactome": "R-CEL-2301205", "name": "SETD8 monomethylates histone H4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10543382" ], "products": [ "species_77502", "species_10543378" ], "modifiers": [ [ "species_10543801", "catalyst" ] ], "additional_components": [ "species_113531", "Q9GYI0", "WBGene00017920", "P62784", "WBGene00001875", "species_113531", "Q9GYI0", "WBGene00017920", "P62784", "WBGene00001875", "WBGene00004781" ] }, "reaction_10543790": { "compartment": "compartment_7660", "id": "reaction_10543790", "reactome": "R-CEL-2294590", "name": "PLK1 binds phosphorylated condensin II complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10543788", "species_10509851" ], "products": [ "species_10543770" ], "modifiers": [], "additional_components": [ "Q20818", "WBGene00010093", "Q09591", "WBGene00003367", "Q95Y84", "WBGene00001833", "P34341", "WBGene00016202", "Q20060", "WBGene00004874", "P62784", "WBGene00001875", "WBGene00004043", "P62784", "WBGene00001875", "Q20818", "WBGene00010093", "Q09591", "WBGene00003367", "Q95Y84", "WBGene00001833", "P34341", "WBGene00016202", "Q20060", "WBGene00004874", "Q9N2L7", "WBGene00004043" ] }, "reaction_10543577": { "compartment": "compartment_20699", "id": "reaction_10543577", "reactome": "R-CEL-2214351", "name": "PLK1 phosphorylates GORASP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10543569" ], "products": [ "species_29370", "species_10543574" ], "modifiers": [ [ "species_10543569", "catalyst" ] ], "additional_components": [ "Q9N2L7", "WBGene00004043", "Q19989", "WBGene00018017", "Q9N3Y1", "WBGene00021536", "Q9UAQ6", "WBGene00004266", "species_29438", "Q19989", "WBGene00018017", "Q9N3Y1", "WBGene00021536", "Q9N2L7", "WBGene00004043", "Q9UAQ6", "WBGene00004266", "species_29438", "Q9N2L7", "WBGene00004043", "Q19989", "WBGene00018017", "Q9N3Y1", "WBGene00021536", "Q9UAQ6", "WBGene00004266", "species_29438" ] }, "reaction_10544207": { "compartment": "compartment_20699", "id": "reaction_10544207", "reactome": "R-CEL-2422927", "name": "MAPK3-3 or MAPK1 phosphorylate GORASP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10544192" ], "products": [ "species_29370", "species_10544198" ], "modifiers": [ [ "species_10544204", "catalyst" ] ], "additional_components": [ "Q9N3Y1", "WBGene00021536", "Q21954", "WBGene00020018", "A0A2C9C2Y0", "WBGene00006833", "species_29438", "Q9N3Y1", "WBGene00021536", "Q21954", "WBGene00020018", "A0A2C9C2Y0", "WBGene00006833", "species_29438" ] }, "reaction_10514372": { "compartment": "compartment_7660", "id": "reaction_10514372", "reactome": "R-CEL-199839", "name": "AKT can phosphorylate RSK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10514366" ], "products": [ "species_113582", "species_10514370" ], "modifiers": [ [ "species_10514266", "catalyst" ] ], "additional_components": [ "WBGene00012929", "WBGene00012929", "G4S4W1", "WBGene00016980", "Q17941", "WBGene00000102", "Q9XTG7", "WBGene00000103" ] }, "reaction_10514300": { "compartment": "compartment_7660", "id": "reaction_10514300", "reactome": "R-CEL-199299", "name": "AKT phosphorylates FOXO transcription factors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10514274" ], "products": [ "species_113582", "species_10514285" ], "modifiers": [ [ "species_10514266", "catalyst" ] ], "additional_components": [ "WBGene00000912", "WBGene00000912", "G4S4W1", "WBGene00016980", "Q17941", "WBGene00000102", "Q9XTG7", "WBGene00000103" ] }, "reaction_10514269": { "compartment": "compartment_7660", "id": "reaction_10514269", "reactome": "R-CEL-199298", "name": "AKT phosphorylates CREB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10514243" ], "products": [ "species_113582", "species_10514246" ], "modifiers": [ [ "species_10514266", "catalyst" ] ], "additional_components": [ "WBGene00000793", "WBGene00000793", "G4S4W1", "WBGene00016980", "Q17941", "WBGene00000102", "Q9XTG7", "WBGene00000103" ] }, "reaction_10514382": { "compartment": "compartment_7660", "id": "reaction_10514382", "reactome": "R-CEL-199863", "name": "AKT can phosphorylate NR4A1 (NUR77)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10514377" ], "products": [ "species_113582", "species_10514380" ], "modifiers": [ [ "species_10514266", "catalyst" ] ], "additional_components": [ "WBGene00003605", "WBGene00003605", "G4S4W1", "WBGene00016980", "Q17941", "WBGene00000102", "Q9XTG7", "WBGene00000103" ] }, "reaction_10571544": { "compartment": "compartment_70101", "id": "reaction_10571544", "reactome": "R-CEL-9027043", "name": "CYPs hydroxylate DHA to 14(R)-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29368", "species_29364", "species_9024011" ], "products": [ "species_29356", "species_29366", "species_9027049" ], "modifiers": [ [ "species_10507820", "catalyst" ] ], "additional_components": [ "Q965T7", "WBGene00021710", "O16671", "WBGene00018261", "O45659", "WBGene00010589", "Q9N4Q4", "WBGene00021168", "A0A0M7RF98", "WBGene00018264", "O16673", "WBGene00018260", "O61204", "WBGene00015045", "Q9N5I1", "WBGene00019565", "G5ECD0", "WBGene00007362", "O44649", "WBGene00019473", "O61935", "WBGene00020386", "G5EE22", "WBGene00012448", "O44650", "WBGene00019472", "O62377", "WBGene00011699", "H2KY69", "WBGene00015044", "O44651", "WBGene00019471", "O62378", "WBGene00011698", "H2KYS3", "WBGene00000905", "O44652", "WBGene00019470", "P90771", "WBGene00007913", "O02627", "WBGene00015399", "O44655", "WBGene00015040", "Q20315", "WBGene00018333", "O02628", "WBGene00015400", "O44656", "WBGene00015041", "Q27465", "WBGene00015135", "O02641", "WBGene00019967", "O44657", "WBGene00015042", "Q27470", "WBGene00015709", "O16220", "WBGene00016786", "O44658", "WBGene00015043", "Q27471", "WBGene00016092", "O16362", "WBGene00018413", "O44704", "WBGene00016686", "Q27482", "WBGene00016768", "O16482", "WBGene00016860", "O44706", "WBGene00016697", "Q27499", "WBGene00018334", "O16670", "WBGene00018262", "O45364", "WBGene00008829" ] }, "reaction_10523346": { "compartment": "compartment_70101", "id": "reaction_10523346", "reactome": "R-CEL-428941", "name": "P2Y purinoceptor 1 activates MAP kinase p38 alpha", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10523344" ], "products": [ "species_10512654", "species_29370" ], "modifiers": [ [ "species_10508937", "catalyst" ] ], "additional_components": [ "WBGene00004055", "WBGene00004055", "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196", "species_29438" ] }, "reaction_10521881": { "compartment": "compartment_70101", "id": "reaction_10521881", "reactome": "R-CEL-418662", "name": "Src activation following P2Y purinoceptor activation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10513079" ], "products": [ "species_10518252" ], "modifiers": [], "additional_components": [ "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635" ] }, "reaction_10556833": { "compartment": "compartment_70101", "id": "reaction_10556833", "reactome": "R-CEL-5691431", "name": "PSMD14 cleaves K63-linked ubiquitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10511035" ], "products": [ "species_10511033" ], "modifiers": [ [ "species_10502380", "catalyst" ] ], "additional_components": [ "P37165", "WBGene00006725", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "WBGene00004467" ] }, "reaction_10556830": { "compartment": "compartment_7660", "id": "reaction_10556830", "reactome": "R-CEL-5691381", "name": "MYSM1 deubiquitinates Histone H2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10556825" ], "products": [ "species_10502318", "species_10556827" ], "modifiers": [ [ "species_10556825", "catalyst" ] ], "additional_components": [ "P34545", "WBGene00000366", "Q9N3S7", "WBGene00021636", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "P34545", "WBGene00000366", "Q9N3S7", "WBGene00021636", "P34545", "WBGene00000366", "Q9N3S7", "WBGene00021636" ] }, "reaction_10511057": { "compartment": "compartment_5460", "id": "reaction_10511057", "reactome": "R-CEL-169260", "name": "Reducing equivalents from beta-oxidation of fatty acids transfer to ETF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10511052", "species_31649" ], "products": [ "species_10511054", "species_113596" ], "modifiers": [ [ "species_10511052", "catalyst" ] ], "additional_components": [ "Q93615", "WBGene00009187", "Q9TXI4", "WBGene00017734", "species_76577", "species_113596", "species_31649", "Q93615", "WBGene00009187", "Q9TXI4", "WBGene00017734", "species_76577", "Q93615", "WBGene00009187", "Q9TXI4", "WBGene00017734", "species_76577", "species_113596" ] }, "reaction_10511065": { "compartment": "compartment_5460", "id": "reaction_10511065", "reactome": "R-CEL-169270", "name": "ETFDH oxidises ETF (reduced) to ETF, reduces CoQ to QH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73663", "species_10511054" ], "products": [ "species_10511052", "species_76633" ], "modifiers": [ [ "species_10511062", "catalyst" ] ], "additional_components": [ "species_31649", "Q93615", "WBGene00009187", "Q9TXI4", "WBGene00017734", "species_76577", "Q93615", "WBGene00009187", "Q9TXI4", "WBGene00017734", "species_76577", "species_113596", "WBGene00002855" ] }, "reaction_10562852": { "compartment": "compartment_5460", "id": "reaction_10562852", "reactome": "R-CEL-6800868", "name": "NDUF subunits bind to form the IP subcomplex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10561725", "species_10561709", "species_10561720", "species_10561718", "species_10561716" ], "products": [ "species_10561727" ], "modifiers": [], "additional_components": [ "WBGene00020417", "Q93873", "WBGene00001520", "Q09644", "WBGene00014227", "Q22619", "WBGene00020636", "Q94360", "WBGene00012376", "Q9N3H3", "WBGene00021800", "species_113596", "Q9N3H3", "WBGene00021800", "species_113596", "Q94360", "WBGene00012376", "Q22619", "WBGene00020636", "Q93873", "WBGene00001520", "Q09644", "WBGene00014227", "Q86NC2", "WBGene00020417" ] }, "reaction_10561780": { "compartment": "compartment_5460", "id": "reaction_10561780", "reactome": "R-CEL-6799203", "name": "IP subcomplex binds NDUFAF3, NDUFAF4, TIMMDC1 to form Intermediate 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10561742", "species_10561727", "species_10561737", "species_10561732" ], "products": [ "species_10561744" ], "modifiers": [], "additional_components": [ "WBGene00021421", "Q9N3H3", "WBGene00021800", "species_113596", "Q94360", "WBGene00012376", "Q22619", "WBGene00020636", "Q93873", "WBGene00001520", "Q09644", "WBGene00014227", "Q86NC2", "WBGene00020417", "WBGene00007113", "WBGene00011123", "Q93931", "WBGene00011123", "Q17439", "WBGene00007113", "Q9N3H3", "WBGene00021800", "species_113596", "Q94360", "WBGene00012376", "Q22619", "WBGene00020636", "Q93873", "WBGene00001520", "Q09644", "WBGene00014227", "Q86NC2", "WBGene00020417", "I2HAE1", "WBGene00021421" ] }, "reaction_10561748": { "compartment": "compartment_70616", "id": "reaction_10561748", "reactome": "R-CEL-6799178", "name": "Intermediate 1 binds HP subcomplex to form Intermediate 2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10561700", "species_10561744" ], "products": [ "species_10561746" ], "modifiers": [], "additional_components": [ "Q20412", "WBGene00009712", "Q18359", "WBGene00007880", "Q93831", "WBGene00010326", "Q18095", "WBGene00007684", "Q9BL33", "WBGene00022169", "Q9XWG2", "WBGene00013406", "Q23098", "WBGene00012166", "O44955", "WBGene00016393", "H2KYV1", "WBGene00016118", "O18236", "WBGene00013308", "Q9U241", "WBGene00013237", "P90789", "WBGene00008414", "O44509", "WBGene00018361", "O02267", "WBGene00009740", "Q21233", "WBGene00019401", "species_113596", "Q9XWJ5", "WBGene00013094", "Q9BL03", "WBGene00021849", "Q18036", "WBGene00015810", "Q93931", "WBGene00011123", "Q17439", "WBGene00007113", "Q9N3H3", "WBGene00021800", "species_113596", "Q94360", "WBGene00012376", "Q22619", "WBGene00020636", "Q93873", "WBGene00001520", "Q09644", "WBGene00014227", "Q86NC2", "WBGene00020417", "I2HAE1", "WBGene00021421", "Q93931", "WBGene00011123", "Q17439", "WBGene00007113", "Q9N3H3", "WBGene00021800", "species_113596", "Q94360", "WBGene00012376", "Q22619", "WBGene00020636", "Q93873", "WBGene00001520", "Q09644", "WBGene00014227", "Q86NC2", "WBGene00020417", "I2HAE1", "WBGene00021421", "Q20412", "WBGene00009712", "Q18359", "WBGene00007880", "Q93831", "WBGene00010326", "Q18095", "WBGene00007684", "Q9BL33", "WBGene00022169", "Q9XWG2", "WBGene00013406", "Q23098", "WBGene00012166", "O44955", "WBGene00016393", "H2KYV1", "WBGene00016118", "O18236", "WBGene00013308", "Q9U241", "WBGene00013237", "P90789", "WBGene00008414", "O44509", "WBGene00018361", "O02267", "WBGene00009740", "Q21233", "WBGene00019401", "Q9XWJ5", "WBGene00013094", "Q9BL03", "WBGene00021849", "Q18036", "WBGene00015810" ] }, "reaction_10521531": { "compartment": "compartment_7660", "id": "reaction_10521531", "reactome": "R-CEL-400204", "name": "PPARA binds RXRA forming PPARA:RXRA heterodimer at promoter of target gene", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10514477", "species_422139", "species_10519403" ], "products": [ "species_10521529" ], "modifiers": [], "additional_components": [ "WBGene00003681", "P41830", "WBGene00004786", "Q10902", "WBGene00003601", "Q20765", "WBGene00003606", "Q9XUK7", "WBGene00003675", "P41830", "WBGene00004786", "Q10902", "WBGene00003601", "Q20765", "WBGene00003606", "Q9XUK7", "WBGene00003675", "Q9U2R6", "WBGene00003681" ] }, "reaction_10542707": { "compartment": "compartment_70101", "id": "reaction_10542707", "reactome": "R-CEL-2106614", "name": "Duplex miRNA is loaded into Argonaute", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10542705" ], "products": [ "species_10516856" ], "modifiers": [], "additional_components": [ "P34529", "WBGene00000939", "G5EBF5", "WBGene00004326", "G5EES3", "WBGene00000105", "P34529", "WBGene00000939", "G5EES3", "WBGene00000105", "G5EBF5", "WBGene00004326" ] }, "reaction_10516876": { "compartment": "compartment_70101", "id": "reaction_10516876", "reactome": "R-CEL-210805", "name": "Removal of miRNA passenger strand", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10516856" ], "products": [ "species_10516874" ], "modifiers": [], "additional_components": [ "P34529", "WBGene00000939", "G5EES3", "WBGene00000105", "G5EBF5", "WBGene00004326", "P34529", "WBGene00000939", "G5EES3", "WBGene00000105", "G5EBF5", "WBGene00004326" ] }, "reaction_10567937": { "compartment": "compartment_70101", "id": "reaction_10567937", "reactome": "R-CEL-8931974", "name": "N6AMT2 transfers 3xCH3 from 3xAdoMet to EEF1A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71284", "species_10509904" ], "products": [ "species_10567929", "species_71285" ], "modifiers": [ [ "species_10567934", "catalyst" ] ], "additional_components": [ "WBGene00001168", "WBGene00001168", "WBGene00043057" ] }, "reaction_10568005": { "compartment": "compartment_70101", "id": "reaction_10568005", "reactome": "R-CEL-8932413", "name": "METTL10 transfers 3xCH3 from 3xAdoMet to EEF1A1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71284", "species_10509904" ], "products": [ "species_10567997", "species_71285" ], "modifiers": [ [ "species_10568002", "catalyst" ] ], "additional_components": [ "WBGene00001168", "WBGene00001168", "WBGene00017919" ] }, "reaction_10567926": { "compartment": "compartment_5460", "id": "reaction_10567926", "reactome": "R-CEL-8931858", "name": "ETFBKMT transfers 3xCH3 from 3xAdoMet to ETFB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10511050", "species_2162265" ], "products": [ "species_10567918", "species_2162252" ], "modifiers": [ [ "species_10567923", "catalyst" ] ], "additional_components": [ "WBGene00017734", "WBGene00017734", "WBGene00016492" ] }, "reaction_10567962": { "compartment": "compartment_70101", "id": "reaction_10567962", "reactome": "R-CEL-8932276", "name": "VCPKMT (METTL21D) transfers 3xCH3 from 3xAdoMet to VCP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71284", "species_10551284" ], "products": [ "species_71285", "species_10567954" ], "modifiers": [ [ "species_10567959", "catalyst" ] ], "additional_components": [ "WBGene00008053", "WBGene00008053", "WBGene00016591" ] }, "reaction_10523164": { "compartment": "compartment_876", "id": "reaction_10523164", "reactome": "R-CEL-428510", "name": "ROBO3.1 antagonizes ROBO1/ROBO2 to allow floor plate crossing", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10523160", "species_10523158" ], "products": [ "species_10523162" ], "modifiers": [], "additional_components": [ "WBGene00004732", "H2KZ60", "WBGene00016354", "Q18806", "WBGene00004370", "H2KZ60", "WBGene00016354", "Q18806", "WBGene00004370", "Q53U87", "WBGene00004732" ] }, "reaction_10568768": { "compartment": "compartment_17957", "id": "reaction_10568768", "reactome": "R-CEL-8944257", "name": "Association of procollagen type XXIV", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10539093" ], "products": [ "species_10540952" ], "modifiers": [], "additional_components": [ "WBGene00000659", "Q21437", "WBGene00000659" ] }, "reaction_10568770": { "compartment": "compartment_17957", "id": "reaction_10568770", "reactome": "R-CEL-8944261", "name": "Association of procollagen type XIII", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10540942" ], "products": [ "species_10540944" ], "modifiers": [], "additional_components": [ "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689", "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689" ] }, "reaction_10568772": { "compartment": "compartment_17957", "id": "reaction_10568772", "reactome": "R-CEL-8944262", "name": "Association of procollagen type X", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10540932" ], "products": [ "species_10540934" ], "modifiers": [], "additional_components": [ "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689", "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689" ] }, "reaction_10568774": { "compartment": "compartment_17957", "id": "reaction_10568774", "reactome": "R-CEL-8944263", "name": "Association of procollagen type II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10540908" ], "products": [ "species_10540910" ], "modifiers": [], "additional_components": [ "O76368", "WBGene00000674", "Q09457", "WBGene00000251", "Q9N4U2", "WBGene00000647", "O76368", "WBGene00000674", "Q09457", "WBGene00000251", "Q9N4U2", "WBGene00000647" ] }, "reaction_10539495": { "compartment": "compartment_17957", "id": "reaction_10539495", "reactome": "R-CEL-2002401", "name": "Association of procollagen type XVIII", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10539097" ], "products": [ "species_10539493" ], "modifiers": [], "additional_components": [ "WBGene00000659", "Q21437", "WBGene00000659" ] }, "reaction_10568776": { "compartment": "compartment_17957", "id": "reaction_10568776", "reactome": "R-CEL-8944266", "name": "Association of procollagen type XI", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10540908", "species_10540938", "species_10540936" ], "products": [ "species_10540940" ], "modifiers": [], "additional_components": [ "O76368", "WBGene00000674", "Q09457", "WBGene00000251", "Q9N4U2", "WBGene00000647", "Q9N3X9", "WBGene00000689", "O17641", "WBGene00000751", "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689", "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689", "O76368", "WBGene00000674", "Q09457", "WBGene00000251", "Q9N4U2", "WBGene00000647" ] }, "reaction_10568754": { "compartment": "compartment_17957", "id": "reaction_10568754", "reactome": "R-CEL-8944214", "name": "Association of procollagen type I", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10536687", "species_10539099" ], "products": [ "species_10540906" ], "modifiers": [], "additional_components": [ "WBGene00000647", "WBGene00000647", "Q9N4U2", "WBGene00000647" ] }, "reaction_10568756": { "compartment": "compartment_17957", "id": "reaction_10568756", "reactome": "R-CEL-8944218", "name": "Association of procollagen type VIII", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10539063", "species_10540928" ], "products": [ "species_10540930" ], "modifiers": [], "additional_components": [ "WBGene00000751", "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689", "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689" ] }, "reaction_10568758": { "compartment": "compartment_17957", "id": "reaction_10568758", "reactome": "R-CEL-8944223", "name": "Association of procollagen type V", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10540920", "species_10539061", "species_10540916" ], "products": [ "species_10540926" ], "modifiers": [], "additional_components": [ "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689", "WBGene00002280", "O76368", "WBGene00000674", "Q09457", "WBGene00000251", "Q9N4U2", "WBGene00000647", "O76368", "WBGene00000674", "Q09457", "WBGene00000251", "Q9N4U2", "WBGene00000647", "P17140", "WBGene00002280", "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689" ] }, "reaction_10568762": { "compartment": "compartment_17957", "id": "reaction_10568762", "reactome": "R-CEL-8944233", "name": "Association of procollagen type XIX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10540948" ], "products": [ "species_10540950" ], "modifiers": [], "additional_components": [ "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689", "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689" ] }, "reaction_10568764": { "compartment": "compartment_17957", "id": "reaction_10568764", "reactome": "R-CEL-8944240", "name": "Association of procollagen type III", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10540912" ], "products": [ "species_10540914" ], "modifiers": [], "additional_components": [ "Q9N4U2", "WBGene00000647", "O76368", "WBGene00000674", "Q09457", "WBGene00000251", "Q9N4U2", "WBGene00000647", "O76368", "WBGene00000674", "Q09457", "WBGene00000251" ] }, "reaction_10568766": { "compartment": "compartment_17957", "id": "reaction_10568766", "reactome": "R-CEL-8944242", "name": "Association of procollagen type XXVII", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10539095" ], "products": [ "species_10540954" ], "modifiers": [], "additional_components": [ "WBGene00002280", "P17140", "WBGene00002280" ] }, "reaction_10512308": { "compartment": "compartment_70101", "id": "reaction_10512308", "reactome": "R-CEL-183058", "name": "Phosphorylation of CBL (EGFR:GRB2:CBL)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10512305" ], "products": [ "species_29370", "species_10512272" ], "modifiers": [ [ "species_10512305", "catalyst" ] ], "additional_components": [ "P24348", "WBGene00002299", "P29355", "WBGene00004774", "Q19019", "WBGene00004829", "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "P29355", "WBGene00004774", "P24348", "WBGene00002299", "P29355", "WBGene00004774", "Q19019", "WBGene00004829" ] }, "reaction_10566342": { "compartment": "compartment_876", "id": "reaction_10566342", "reactome": "R-CEL-8867041", "name": "EGFR phosphorylates EPS15", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10566337" ], "products": [ "species_29370", "species_10566339" ], "modifiers": [ [ "species_10566337", "catalyst" ] ], "additional_components": [ "Q9BIF4", "WBGene00001224", "species_179856", "Q18453", "WBGene00004682", "Q9BI71", "WBGene00001329", "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "B1V8A0", "WBGene00006791", "P29355", "WBGene00004774", "Q17796", "WBGene00004101", "O01498", "WBGene00004109", "Q9BIF4", "WBGene00001224", "species_179856", "Q17796", "WBGene00004101", "O01498", "WBGene00004109", "Q18453", "WBGene00004682", "Q9BI71", "WBGene00001329", "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "B1V8A0", "WBGene00006791", "P29355", "WBGene00004774", "Q9BIF4", "WBGene00001224", "species_179856", "Q18453", "WBGene00004682", "Q9BI71", "WBGene00001329", "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "B1V8A0", "WBGene00006791", "P29355", "WBGene00004774", "Q17796", "WBGene00004101", "O01498", "WBGene00004109" ] }, "reaction_10512298": { "compartment": "compartment_70101", "id": "reaction_10512298", "reactome": "R-CEL-183036", "name": "Ubiquitination of stimulated EGFR (CBL:GRB2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502375", "species_10512272" ], "products": [ "species_10512290" ], "modifiers": [ [ "species_10512272", "catalyst" ], [ "species_10512296", "inhibitor" ] ], "additional_components": [ "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "P29355", "WBGene00004774", "P29355", "WBGene00004774", "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "P29355", "WBGene00004774", "WBGene00011755" ] }, "reaction_10512315": { "compartment": "compartment_70101", "id": "reaction_10512315", "reactome": "R-CEL-183084", "name": "CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502375", "species_10512310" ], "products": [ "species_10512312", "species_10512305" ], "modifiers": [ [ "species_10512310", "catalyst" ] ], "additional_components": [ "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "P29355", "WBGene00004774", "Q05062", "WBGene00000390", "species_29438", "Q21430", "WBGene00010776", "Q05062", "WBGene00000390", "species_29438", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "Q21430", "WBGene00010776", "P24348", "WBGene00002299", "P29355", "WBGene00004774", "Q19019", "WBGene00004829", "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "P29355", "WBGene00004774", "Q05062", "WBGene00000390", "species_29438", "Q21430", "WBGene00010776" ] }, "reaction_10512270": { "compartment": "compartment_70101", "id": "reaction_10512270", "reactome": "R-CEL-182986", "name": "CBL-mediated ubiquitination of CIN85", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10512255", "species_10502375" ], "products": [ "species_10512265" ], "modifiers": [ [ "species_10512255", "catalyst" ] ], "additional_components": [ "Q9BIF4", "WBGene00001224", "B1V8A0", "WBGene00006791", "Q18453", "WBGene00004682", "Q9BI71", "WBGene00001329", "P24348", "WBGene00002299", "Q19019", "WBGene00004829", "Q17796", "WBGene00004101", "O01498", "WBGene00004109", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "Q9BIF4", "WBGene00001224", "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "B1V8A0", "WBGene00006791", "Q18453", "WBGene00004682", "Q9BI71", "WBGene00001329", "Q17796", "WBGene00004101", "O01498", "WBGene00004109", "Q9BIF4", "WBGene00001224", "B1V8A0", "WBGene00006791", "Q18453", "WBGene00004682", "Q9BI71", "WBGene00001329", "P24348", "WBGene00002299", "Q19019", "WBGene00004829", "Q17796", "WBGene00004101", "O01498", "WBGene00004109" ] }, "reaction_10512303": { "compartment": "compartment_70101", "id": "reaction_10512303", "reactome": "R-CEL-183052", "name": "CBL binds to GRB2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10512267", "species_10506871" ], "products": [ "species_10512301" ], "modifiers": [], "additional_components": [ "WBGene00004829", "WBGene00004774", "P29355", "WBGene00004774", "Q19019", "WBGene00004829" ] }, "reaction_10512319": { "compartment": "compartment_70101", "id": "reaction_10512319", "reactome": "R-CEL-183094", "name": "CDC42:GTP binds CBL:Beta-Pix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10512286", "species_10512267" ], "products": [ "species_10512317" ], "modifiers": [], "additional_components": [ "Q05062", "WBGene00000390", "species_29438", "Q21430", "WBGene00010776", "WBGene00004829", "Q19019", "WBGene00004829", "Q05062", "WBGene00000390", "species_29438", "Q21430", "WBGene00010776" ] }, "reaction_10566350": { "compartment": "compartment_876", "id": "reaction_10566350", "reactome": "R-CEL-8867047", "name": "PTPN3 dephosphorylates EPS15", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10566339" ], "products": [ "species_29372", "species_10566337" ], "modifiers": [ [ "species_10566347", "catalyst" ] ], "additional_components": [ "Q9BIF4", "WBGene00001224", "species_179856", "Q17796", "WBGene00004101", "O01498", "WBGene00004109", "Q18453", "WBGene00004682", "Q9BI71", "WBGene00001329", "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "B1V8A0", "WBGene00006791", "P29355", "WBGene00004774", "Q9BIF4", "WBGene00001224", "species_179856", "Q18453", "WBGene00004682", "Q9BI71", "WBGene00001329", "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "B1V8A0", "WBGene00006791", "P29355", "WBGene00004774", "Q17796", "WBGene00004101", "O01498", "WBGene00004109", "WBGene00004213" ] }, "reaction_10541063": { "compartment": "compartment_984", "id": "reaction_10541063", "reactome": "R-CEL-2022381", "name": "Cathepsin Z (Cathepsin X) hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_10541036" ], "products": [ "species_10528011" ], "modifiers": [ [ "species_10541060", "catalyst" ] ], "additional_components": [ "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "A9Z1L1", "WBGene00005648", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "A9Z1L1", "WBGene00005648", "G5ECY2", "WBGene00005644", "Q9XWA4", "WBGene00013764", "Q9XXQ7", "WBGene00013764", "G5EGP8", "WBGene00000788", "P92005", "WBGene00000789", "Q18740", "WBGene00008231", "Q9U2X1", "WBGene00013764" ] }, "reaction_10541193": { "compartment": "compartment_984", "id": "reaction_10541193", "reactome": "R-CEL-2022403", "name": "Renin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10541102", "species_109276" ], "products": [ "species_10541036" ], "modifiers": [ [ "species_10541190", "catalyst" ], [ "species_10541190", "catalyst" ], [ "species_2022362", "inhibitor" ] ], "additional_components": [ "A9Z1L1", "WBGene00005648", "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "A9Z1L1", "WBGene00005648", "Q9XTY9", "WBGene00010993", "Q21966", "WBGene00000217", "O01530", "WBGene00000219", "Q22972", "WBGene00017881", "O01531", "WBGene00017678", "Q7JKL9", "WBGene00013973", "O01532", "WBGene00000218", "Q86NE0", "WBGene00000215", "O45072", "WBGene00015700", "Q8MYN5", "WBGene00012683", "P55956", "WBGene00000216", "G5EC01", "WBGene00077655", "Q8MYN6", "WBGene00012682", "Q18020", "WBGene00007605", "G5EEI4", "WBGene00000214", "Q8MYN7", "WBGene00012681", "Q9XTY9", "WBGene00010993", "Q21966", "WBGene00000217", "O01530", "WBGene00000219", "Q22972", "WBGene00017881", "O01531", "WBGene00017678", "Q7JKL9", "WBGene00013973", "O01532", "WBGene00000218", "Q86NE0", "WBGene00000215", "O45072", "WBGene00015700", "Q8MYN5", "WBGene00012683", "P55956", "WBGene00000216", "G5EC01", "WBGene00077655", "Q8MYN6", "WBGene00012682", "Q18020", "WBGene00007605", "G5EEI4", "WBGene00000214", "Q8MYN7", "WBGene00012681" ] }, "reaction_10541065": { "compartment": "compartment_984", "id": "reaction_10541065", "reactome": "R-CEL-2022396", "name": "Neprilysin hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-7)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_10541036" ], "products": [ "species_10541012" ], "modifiers": [ [ "species_10541017", "catalyst" ] ], "additional_components": [ "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "A9Z1L1", "WBGene00005648", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "A9Z1L1", "WBGene00005648", "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "WBGene00013926" ] }, "reaction_10541930": { "compartment": "compartment_984", "id": "reaction_10541930", "reactome": "R-CEL-2028294", "name": "Mast Cell Carboxypeptidase hydrolyzes Angiotensin-(1-10) to Yield Angiotensin-(1-9)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_10541036" ], "products": [ "species_10540996" ], "modifiers": [ [ "species_10541927", "catalyst" ] ], "additional_components": [ "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "A9Z1L1", "WBGene00005648", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "A9Z1L1", "WBGene00005648", "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q9BL88", "WBGene00021984", "H2L0D7", "WBGene00021984", "G3MU29", "WBGene00021984", "Q9TZC6", "WBGene00021984", "H2L0K5", "WBGene00021984", "G5EC13", "WBGene00021984", "Q9XU75", "WBGene00011235", "Q6A577", "WBGene00021984", "G5EC96", "WBGene00021984" ] }, "reaction_10541196": { "compartment": "compartment_984", "id": "reaction_10541196", "reactome": "R-CEL-2022405", "name": "ACE hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_10541036" ], "products": [ "species_10528011" ], "modifiers": [ [ "species_10541067", "catalyst" ], [ "species_188972", "catalyst" ] ], "additional_components": [ "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "A9Z1L1", "WBGene00005648", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "A9Z1L1", "WBGene00005648", "G5ECY2", "WBGene00005644", "WBGene00000039" ] }, "reaction_10572173": { "compartment": "compartment_984", "id": "reaction_10572173", "reactome": "R-CEL-9614933", "name": "ACEIs bind ACE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9614913", "species_10542353" ], "products": [ "species_10542356" ], "modifiers": [], "additional_components": [ "WBGene00000039", "Q18581", "WBGene00000039" ] }, "reaction_10541070": { "compartment": "compartment_984", "id": "reaction_10541070", "reactome": "R-CEL-2022398", "name": "ACE hydrolyzes Angiotensin-(1-9) to Angiotensin-(1-7)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_10540996" ], "products": [ "species_10541012" ], "modifiers": [ [ "species_10541067", "catalyst" ] ], "additional_components": [ "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "A9Z1L1", "WBGene00005648", "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "A9Z1L1", "WBGene00005648", "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "WBGene00000039" ] }, "reaction_10541235": { "compartment": "compartment_984", "id": "reaction_10541235", "reactome": "R-CEL-2022412", "name": "Renin hydrolyzes Angiotensinogen to Angiotensin-(1-10)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10541102", "species_109276" ], "products": [ "species_10541036" ], "modifiers": [ [ "species_10541232", "catalyst" ], [ "species_2022362", "inhibitor" ] ], "additional_components": [ "A9Z1L1", "WBGene00005648", "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "A9Z1L1", "WBGene00005648", "Q22972", "WBGene00017881", "Q7JKL9", "WBGene00013973", "Q86NE0", "WBGene00000215", "Q8MYN5", "WBGene00012683", "Q8MYN6", "WBGene00012682", "Q8MYN7", "WBGene00012681", "G5EC01", "WBGene00077655", "G5EEI4", "WBGene00000214", "O01530", "WBGene00000219", "O01531", "WBGene00017678", "O01532", "WBGene00000218", "O45072", "WBGene00015700", "P55956", "WBGene00000216", "Q18020", "WBGene00007605", "Q21966", "WBGene00000217" ] }, "reaction_10541044": { "compartment": "compartment_984", "id": "reaction_10541044", "reactome": "R-CEL-2022378", "name": "ACE2 hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-9)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_10541036" ], "products": [ "species_10540996" ], "modifiers": [ [ "species_10541041", "catalyst" ] ], "additional_components": [ "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "A9Z1L1", "WBGene00005648", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "A9Z1L1", "WBGene00005648", "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "WBGene00000039" ] }, "reaction_10542358": { "compartment": "compartment_984", "id": "reaction_10542358", "reactome": "R-CEL-2065355", "name": "Secreted ACE hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_10541036" ], "products": [ "species_10528011" ], "modifiers": [ [ "species_10542353", "catalyst" ], [ "species_188972", "catalyst" ], [ "species_10542356", "inhibitor" ] ], "additional_components": [ "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "A9Z1L1", "WBGene00005648", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "A9Z1L1", "WBGene00005648", "G5ECY2", "WBGene00005644", "WBGene00000039", "Q18581", "WBGene00000039" ] }, "reaction_10541046": { "compartment": "compartment_984", "id": "reaction_10541046", "reactome": "R-CEL-2022379", "name": "ACE2 hydrolyzes Angiotensin-(1-8) to Angiotensin-(1-7)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_10528011" ], "products": [ "species_10541012" ], "modifiers": [ [ "species_10541041", "catalyst" ] ], "additional_components": [ "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "A9Z1L1", "WBGene00005648", "G5ECY2", "WBGene00005644", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "A9Z1L1", "WBGene00005648", "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "WBGene00000039" ] }, "reaction_10572216": { "compartment": "compartment_984", "id": "reaction_10572216", "reactome": "R-CEL-9619024", "name": "CES1trimer hydrolyses ACEI pro-drugs to ACEIs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113519", "species_9619052" ], "products": [ "species_8878776", "species_9619021" ], "modifiers": [ [ "species_10557032", "catalyst" ] ], "additional_components": [ "Q04457", "WBGene00001578" ] }, "reaction_10542396": { "compartment": "compartment_984", "id": "reaction_10542396", "reactome": "R-CEL-2065357", "name": "Prorenin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10541102", "species_109276" ], "products": [ "species_10541036" ], "modifiers": [ [ "species_10542393", "catalyst" ], [ "species_2022362", "inhibitor" ] ], "additional_components": [ "A9Z1L1", "WBGene00005648", "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "A9Z1L1", "WBGene00005648", "Q9XTY9", "WBGene00010993", "O01532", "WBGene00000218", "O45072", "WBGene00015700", "P55956", "WBGene00000216", "Q18020", "WBGene00007605", "Q21966", "WBGene00000217", "Q22972", "WBGene00017881", "Q7JKL9", "WBGene00013973", "Q86NE0", "WBGene00000215", "Q8MYN5", "WBGene00012683", "Q8MYN6", "WBGene00012682", "Q8MYN7", "WBGene00012681", "G5EC01", "WBGene00077655", "G5EEI4", "WBGene00000214", "O01530", "WBGene00000219", "O01531", "WBGene00017678" ] }, "reaction_10541020": { "compartment": "compartment_984", "id": "reaction_10541020", "reactome": "R-CEL-2022368", "name": "Neprilysin hydrolyzes Angiotensin-(1-9) to Angiotensin-(1-7)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_10540996" ], "products": [ "species_10541012" ], "modifiers": [ [ "species_10541017", "catalyst" ] ], "additional_components": [ "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "A9Z1L1", "WBGene00005648", "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "A9Z1L1", "WBGene00005648", "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "WBGene00013926" ] }, "reaction_10549712": { "compartment": "compartment_7660", "id": "reaction_10549712", "reactome": "R-CEL-4755494", "name": "PIAS1,2-1 SUMOylate NR5A2 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10549685", "species_10546081" ], "products": [ "species_10549707", "species_10546073" ], "modifiers": [ [ "species_10549709", "catalyst" ] ], "additional_components": [ "CHEBI:77361", "Q9N2W3", "WBGene00022374", "Q18190", "WBGene00016126", "Q9XTJ4", "WBGene00003602", "Q19345", "WBGene00003623", "Q21104", "WBGene00003629", "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "CHEBI:77361", "P55853", "WBGene00004888", "Q21104", "WBGene00003629", "Q9N2W3", "WBGene00022374", "Q9XTJ4", "WBGene00003602", "Q18190", "WBGene00016126", "Q19345", "WBGene00003623", "WBGene00006706", "Q21970", "WBGene00011259", "Q94361", "WBGene00001574" ] }, "reaction_10549218": { "compartment": "compartment_7660", "id": "reaction_10549218", "reactome": "R-CEL-4546386", "name": "PIAS1,3 SUMOylates NR5A1 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546081", "species_10519472" ], "products": [ "species_10549213", "species_10546073" ], "modifiers": [ [ "species_10549215", "catalyst" ] ], "additional_components": [ "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "WBGene00003623", "P55853", "WBGene00004888", "Q19345", "WBGene00003623", "WBGene00006706", "Q21970", "WBGene00011259", "Q94361", "WBGene00001574" ] }, "reaction_10549683": { "compartment": "compartment_7660", "id": "reaction_10549683", "reactome": "R-CEL-4755419", "name": "SUMOylation of NR1H4 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10549672", "species_10546081" ], "products": [ "species_10546073", "species_10549681" ], "modifiers": [], "additional_components": [ "G5ECR9", "WBGene00006790", "CHEBI:16755", "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "WBGene00006706", "CHEBI:16755", "P55853", "WBGene00004888", "G5ECR9", "WBGene00006790" ] }, "reaction_10549573": { "compartment": "compartment_7660", "id": "reaction_10549573", "reactome": "R-CEL-4719447", "name": "PIAS2-2 SUMOylates THRA with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546081", "species_10519457" ], "products": [ "species_10546073", "species_10549571" ], "modifiers": [ [ "species_10548942", "catalyst" ] ], "additional_components": [ "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "P41830", "WBGene00004786", "Q10902", "WBGene00003601", "Q20765", "WBGene00003606", "Q9XUK7", "WBGene00003675", "WBGene00006706", "P41830", "WBGene00004786", "Q10902", "WBGene00003601", "Q20765", "WBGene00003606", "Q9XUK7", "WBGene00003675", "P55853", "WBGene00004888", "WBGene00001574" ] }, "reaction_10549096": { "compartment": "compartment_7660", "id": "reaction_10549096", "reactome": "R-CEL-4341048", "name": "SUMOylation of RXRA with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10514477", "species_10546081" ], "products": [ "species_10546073", "species_10549094" ], "modifiers": [ [ "species_10546081", "catalyst" ] ], "additional_components": [ "WBGene00003681", "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "WBGene00006706", "P55853", "WBGene00004888", "Q9U2R6", "WBGene00003681", "Q95017", "WBGene00006706", "P55853", "WBGene00004888" ] }, "reaction_10549548": { "compartment": "compartment_7660", "id": "reaction_10549548", "reactome": "R-CEL-4719436", "name": "PIAS2,3,4 SUMOylate RORA with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10519389", "species_10546081" ], "products": [ "species_10546073", "species_10549543" ], "modifiers": [ [ "species_10549545", "catalyst" ] ], "additional_components": [ "WBGene00003622", "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "WBGene00006706", "P41828", "WBGene00003622", "P55853", "WBGene00004888", "Q21970", "WBGene00011259", "Q94361", "WBGene00001574" ] }, "reaction_10549117": { "compartment": "compartment_7660", "id": "reaction_10549117", "reactome": "R-CEL-4341070", "name": "PIAS4 SUMOylates PPARA with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10519403", "species_10546081" ], "products": [ "species_10549115", "species_10546073" ], "modifiers": [ [ "species_10546168", "catalyst" ] ], "additional_components": [ "P41830", "WBGene00004786", "Q10902", "WBGene00003601", "Q20765", "WBGene00003606", "Q9XUK7", "WBGene00003675", "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "Q10902", "WBGene00003601", "Q20765", "WBGene00003606", "Q9XUK7", "WBGene00003675", "P41830", "WBGene00004786", "P55853", "WBGene00004888", "WBGene00006706", "Q21970", "WBGene00011259", "Q94361", "WBGene00001574" ] }, "reaction_10549535": { "compartment": "compartment_7660", "id": "reaction_10549535", "reactome": "R-CEL-4719424", "name": "PIAS1 SUMOylates THRB with SUMO1.", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10519467", "species_10546081" ], "products": [ "species_10549533", "species_10546073" ], "modifiers": [ [ "species_10528091", "catalyst" ] ], "additional_components": [ "P41830", "WBGene00004786", "Q10902", "WBGene00003601", "Q20765", "WBGene00003606", "Q9XUK7", "WBGene00003675", "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "P55853", "WBGene00004888", "Q20765", "WBGene00003606", "Q9XUK7", "WBGene00003675", "P41830", "WBGene00004786", "Q10902", "WBGene00003601", "WBGene00006706", "Q21970", "WBGene00011259", "Q94361", "WBGene00001574" ] }, "reaction_10554195": { "compartment": "compartment_7660", "id": "reaction_10554195", "reactome": "R-CEL-5649856", "name": "Oxidative damage to the AP site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508796" ], "products": [ "species_10554193" ], "modifiers": [], "additional_components": [ "G5EBR7", "WBGene00001372", "G5EBR7", "WBGene00001372" ] }, "reaction_10508799": { "compartment": "compartment_7660", "id": "reaction_10508799", "reactome": "R-CEL-110359", "name": "APEX1 mediates endonucleolytic cleavage at the 5' side of the AP site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508788" ], "products": [ "species_10508796" ], "modifiers": [ [ "species_10508788", "catalyst" ] ], "additional_components": [ "G5EBR7", "WBGene00001372", "G5EBR7", "WBGene00001372", "G5EBR7", "WBGene00001372" ] }, "reaction_10508673": { "compartment": "compartment_7660", "id": "reaction_10508673", "reactome": "R-CEL-110215", "name": "Cleavage of uracil by UNG glycosylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508666" ], "products": [ "species_10508670", "species_29554" ], "modifiers": [ [ "species_10508666", "catalyst" ] ], "additional_components": [ "Q9U221", "WBGene00013241", "Q9U221", "WBGene00013241", "Q9U221", "WBGene00013241" ] }, "reaction_10508689": { "compartment": "compartment_7660", "id": "reaction_10508689", "reactome": "R-CEL-110224", "name": "Cleavage of thymine glycol by NTHL1 glycosylase ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508684" ], "products": [ "species_10508686", "species_110223" ], "modifiers": [ [ "species_10508684", "catalyst" ] ], "additional_components": [ "P54137", "WBGene00011201", "P54137", "WBGene00011201", "P54137", "WBGene00011201" ] }, "reaction_10508710": { "compartment": "compartment_7660", "id": "reaction_10508710", "reactome": "R-CEL-110229", "name": "Cleavage of formamidopyrimidine (FapyA) by NTHL1 glycosylase ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508707" ], "products": [ "species_10508686", "species_5637659" ], "modifiers": [ [ "species_10508707", "catalyst" ] ], "additional_components": [ "P54137", "WBGene00011201", "P54137", "WBGene00011201", "P54137", "WBGene00011201" ] }, "reaction_10508680": { "compartment": "compartment_7660", "id": "reaction_10508680", "reactome": "R-CEL-110217", "name": "Cleavage of 5-hydroxyluracil by UNG glycosylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508677" ], "products": [ "species_10508670", "species_110216" ], "modifiers": [ [ "species_10508677", "catalyst" ] ], "additional_components": [ "Q9U221", "WBGene00013241", "Q9U221", "WBGene00013241", "Q9U221", "WBGene00013241" ] }, "reaction_10508696": { "compartment": "compartment_7660", "id": "reaction_10508696", "reactome": "R-CEL-110226", "name": "Cleavage of cytosine glycol by NTHL1 glycosylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508693" ], "products": [ "species_10508686", "species_110225" ], "modifiers": [ [ "species_10508693", "catalyst" ] ], "additional_components": [ "P54137", "WBGene00011201", "P54137", "WBGene00011201", "P54137", "WBGene00011201" ] }, "reaction_10508703": { "compartment": "compartment_7660", "id": "reaction_10508703", "reactome": "R-CEL-110227", "name": "Cleavage of dihydrouracil by NTHL1 glycosylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508700" ], "products": [ "species_10508686", "species_30140" ], "modifiers": [ [ "species_10508700", "catalyst" ] ], "additional_components": [ "P54137", "WBGene00011201", "P54137", "WBGene00011201", "P54137", "WBGene00011201" ] }, "reaction_10507554": { "compartment": "compartment_70101", "id": "reaction_10507554", "reactome": "R-CEL-75887", "name": "Conversion of Glycerol to Glycerol-3-phosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_76116" ], "products": [ "species_29370", "species_76114" ], "modifiers": [ [ "species_10507551", "catalyst" ] ], "additional_components": [ "Q21944", "WBGene00020007" ] }, "reaction_10507603": { "compartment": "compartment_70101", "id": "reaction_10507603", "reactome": "R-CEL-75900", "name": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_75967", "species_76103" ], "products": [ "species_549167", "species_76194" ], "modifiers": [ [ "species_10507600", "catalyst" ] ], "additional_components": [ "Q9NCE1", "WBGene00010408" ] }, "reaction_10557589": { "compartment": "compartment_12045", "id": "reaction_10557589", "reactome": "R-CEL-5696119", "name": "AGMO cleaves alkylglycerol into fatty aldehyde and glycerol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29870", "species_5696122", "species_29368" ], "products": [ "species_29356", "species_1497857", "species_76116", "species_5696116" ], "modifiers": [ [ "species_10557586", "catalyst" ] ], "additional_components": [ "WBGene00007210" ] }, "reaction_10507542": { "compartment": "compartment_70101", "id": "reaction_10507542", "reactome": "R-CEL-75886", "name": "glycerol 3-phosphate + acyl-CoA => 1-acylglycerol 3-phosphate + CoASH [mitochondrial membrane-associated]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_75967", "species_76114" ], "products": [ "species_76194", "species_76112" ], "modifiers": [ [ "species_10507537", "catalyst" ] ], "additional_components": [ "WBGene00017261" ] }, "reaction_10527368": { "compartment": "compartment_70101", "id": "reaction_10527368", "reactome": "R-CEL-549192", "name": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_75967", "species_76103" ], "products": [ "species_549167", "species_76194" ], "modifiers": [ [ "species_10527365", "catalyst" ] ], "additional_components": [ "Q9XUW0", "WBGene00010296", "O01881", "WBGene00021818", "Q23067", "WBGene00020910", "Q9N4S3", "WBGene00021818" ] }, "reaction_10507593": { "compartment": "compartment_70101", "id": "reaction_10507593", "reactome": "R-CEL-75899", "name": "1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76108", "species_29356" ], "products": [ "species_29372", "species_76103" ], "modifiers": [ [ "species_10507586", "catalyst" ] ], "additional_components": [ "WBGene00010425" ] }, "reaction_10562170": { "compartment": "compartment_12045", "id": "reaction_10562170", "reactome": "R-CEL-6800334", "name": "MOGAT1,2,3 transfer acyl group from acyl-CoA to 2-acylglycerol to form DAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6800352", "species_1500578" ], "products": [ "species_76103", "species_76194" ], "modifiers": [ [ "species_10562167", "catalyst" ] ], "additional_components": [ "Q9N4S3", "WBGene00021818", "Q9XUW0", "WBGene00010296", "O01881", "WBGene00021818", "Q23067", "WBGene00020910" ] }, "reaction_10523735": { "compartment": "compartment_70101", "id": "reaction_10523735", "reactome": "R-CEL-430311", "name": "Rsu-1 interacts with Pinch1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10523726", "species_10523731" ], "products": [ "species_10523733" ], "modifiers": [], "additional_components": [ "WBGene00007924", "WBGene00006826", "P50464", "WBGene00006826", "Q09497", "WBGene00007924" ] }, "reaction_10524057": { "compartment": "compartment_70101", "id": "reaction_10524057", "reactome": "R-CEL-432946", "name": "PARVB/Affixin interacts with alpha PIX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10516119", "species_10523717" ], "products": [ "species_10524055" ], "modifiers": [], "additional_components": [ "WBGene00010776", "WBGene00003932", "O16785", "WBGene00003932", "Q21430", "WBGene00010776" ] }, "reaction_10523721": { "compartment": "compartment_70101", "id": "reaction_10523721", "reactome": "R-CEL-430308", "name": "PARVB interacts with Alpha-actinin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10523717", "species_10523712" ], "products": [ "species_10523719" ], "modifiers": [], "additional_components": [ "WBGene00003932", "WBGene00000228", "Q23158", "WBGene00000228", "O16785", "WBGene00003932" ] }, "reaction_10512192": { "compartment": "compartment_70101", "id": "reaction_10512192", "reactome": "R-CEL-179467", "name": "GAB1 binds phosphatidylinositol-3,4,5-trisphosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179838", "species_10512121" ], "products": [ "species_10512159" ], "modifiers": [], "additional_components": [ "P29355", "WBGene00004774", "G5EDJ4", "WBGene00004928", "P29355", "WBGene00004774", "G5EDJ4", "WBGene00004928", "species_179838" ] }, "reaction_10512183": { "compartment": "compartment_70101", "id": "reaction_10512183", "reactome": "R-CEL-177939", "name": "PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10512155", "catalyst" ] ], "additional_components": [ "P24348", "WBGene00002299", "G5EDJ4", "WBGene00004928", "P29355", "WBGene00004774", "species_179838", "G5EDP9", "WBGene00000001", "Q94125", "WBGene00000090" ] }, "reaction_10512169": { "compartment": "compartment_70101", "id": "reaction_10512169", "reactome": "R-CEL-177930", "name": "GAB1 phosphorylation by EGFR kinase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10512163" ], "products": [ "species_29370", "species_10512153" ], "modifiers": [ [ "species_10512163", "catalyst" ] ], "additional_components": [ "P29355", "WBGene00004774", "G5EDJ4", "WBGene00004928", "species_179838", "P24348", "WBGene00002299", "P24348", "WBGene00002299", "G5EDJ4", "WBGene00004928", "P29355", "WBGene00004774", "species_179838", "P29355", "WBGene00004774", "G5EDJ4", "WBGene00004928", "species_179838", "P24348", "WBGene00002299" ] }, "reaction_10512123": { "compartment": "compartment_70101", "id": "reaction_10512123", "reactome": "R-CEL-177920", "name": "Binding of GRB2 to GAB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10506871", "species_10512119" ], "products": [ "species_10512121" ], "modifiers": [], "additional_components": [ "WBGene00004774", "WBGene00004928", "P29355", "WBGene00004774", "G5EDJ4", "WBGene00004928" ] }, "reaction_10512157": { "compartment": "compartment_876", "id": "reaction_10512157", "reactome": "R-CEL-177927", "name": "PI3K binds to EGF:EGFR:GRB2:GAB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10506892", "species_10512153" ], "products": [ "species_10512155" ], "modifiers": [], "additional_components": [ "G5EDP9", "WBGene00000001", "Q94125", "WBGene00000090", "P24348", "WBGene00002299", "G5EDJ4", "WBGene00004928", "P29355", "WBGene00004774", "species_179838", "P24348", "WBGene00002299", "G5EDJ4", "WBGene00004928", "P29355", "WBGene00004774", "species_179838", "G5EDP9", "WBGene00000001", "Q94125", "WBGene00000090" ] }, "reaction_10519952": { "compartment": "compartment_876", "id": "reaction_10519952", "reactome": "R-CEL-380905", "name": "Serotonin loaded synaptic vesicle docking and priming", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10516749", "species_10516777", "species_10519865", "species_10519944", "species_10516744", "species_10516631", "species_10516739" ], "products": [ "species_10519946" ], "modifiers": [ [ "species_10519944", "catalyst" ] ], "additional_components": [ "WBGene00006798", "Q21049", "WBGene00006364", "Q22366", "WBGene00006750", "P27715", "WBGene00006752", "Q9N415", "WBGene00006513", "Q94057", "WBGene00044062", "Q95XH1", "WBGene00022077", "G5EBK2", "WBGene00014084", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q19767", "WBGene00004898", "Q9GNP0", "WBGene00000295", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "Q94986", "WBGene00004267", "species_380585", "WBGene00022271", "WBGene00006757", "G5EEN8", "WBGene00006454", "A5PEW5", "WBGene00004364", "G5EEN8", "WBGene00006454", "A5PEW5", "WBGene00004364", "P34815", "WBGene00006757", "Q94057", "WBGene00044062", "Q95XH1", "WBGene00022077", "G5EBK2", "WBGene00014084", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q19767", "WBGene00004898", "Q9GNP0", "WBGene00000295", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "Q94986", "WBGene00004267", "species_380585", "Q9GUM7", "WBGene00022271", "Q21049", "WBGene00006364", "Q22366", "WBGene00006750", "P27715", "WBGene00006752", "Q9N415", "WBGene00006513", "O16000", "WBGene00006798", "Q94057", "WBGene00044062", "Q95XH1", "WBGene00022077", "G5EBK2", "WBGene00014084", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q19767", "WBGene00004898", "Q9GNP0", "WBGene00000295", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "Q94986", "WBGene00004267", "species_380585" ] }, "reaction_10519894": { "compartment": "compartment_374932", "id": "reaction_10519894", "reactome": "R-CEL-380586", "name": "loading of Serotonin in synaptic vesicles", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_209914" ], "products": [ "species_380585" ], "modifiers": [ [ "species_10518406", "catalyst" ] ], "additional_components": [ "WBGene00000295" ] }, "reaction_10519949": { "compartment": "compartment_984", "id": "reaction_10519949", "reactome": "R-CEL-380901", "name": "Release of docked serotonin loaded synaptic vesicle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10519946" ], "products": [ "species_10518827", "species_114523", "species_10516777", "species_10519865", "species_10516825", "species_10516744", "species_10516631", "species_10516823", "species_10516807" ], "modifiers": [ [ "species_10519946", "catalyst" ] ], "additional_components": [ "G5EEN8", "WBGene00006454", "A5PEW5", "WBGene00004364", "P34815", "WBGene00006757", "Q94057", "WBGene00044062", "Q95XH1", "WBGene00022077", "G5EBK2", "WBGene00014084", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q19767", "WBGene00004898", "Q9GNP0", "WBGene00000295", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "Q94986", "WBGene00004267", "species_380585", "Q9GUM7", "WBGene00022271", "Q21049", "WBGene00006364", "Q22366", "WBGene00006750", "P27715", "WBGene00006752", "Q9N415", "WBGene00006513", "O16000", "WBGene00006798", "WBGene00000295", "Q21049", "WBGene00006364", "Q22366", "WBGene00006750", "P27715", "WBGene00006752", "Q9N415", "WBGene00006513", "WBGene00004267", "WBGene00022271", "WBGene00006757", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "G5EEN8", "WBGene00006454", "A5PEW5", "WBGene00004364", "Q94057", "WBGene00044062", "Q95XH1", "WBGene00022077", "G5EBK2", "WBGene00014084", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q19767", "WBGene00004898", "O16000", "WBGene00006798", "G5EEN8", "WBGene00006454", "A5PEW5", "WBGene00004364", "P34815", "WBGene00006757", "Q94057", "WBGene00044062", "Q95XH1", "WBGene00022077", "G5EBK2", "WBGene00014084", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q19767", "WBGene00004898", "Q9GNP0", "WBGene00000295", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "Q94986", "WBGene00004267", "species_380585", "Q9GUM7", "WBGene00022271", "Q21049", "WBGene00006364", "Q22366", "WBGene00006750", "P27715", "WBGene00006752", "Q9N415", "WBGene00006513", "O16000", "WBGene00006798" ] }, "reaction_10522699": { "compartment": "compartment_876", "id": "reaction_10522699", "reactome": "R-CEL-426223", "name": "Cation influx mediated by TRPC3/6/7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426219" ], "products": [ "species_426221" ], "modifiers": [ [ "species_10522694", "catalyst" ] ], "additional_components": [ "species_83910", "species_74016", "species_114632", "species_74016", "species_114632", "species_83910", "Q8I6Y9", "WBGene00006615", "species_114519" ] }, "reaction_10520082": { "compartment": "compartment_876", "id": "reaction_10520082", "reactome": "R-CEL-381668", "name": "cAMP activates EPAC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10520078", "species_30389" ], "products": [ "species_10520080" ], "modifiers": [], "additional_components": [ "WBGene00004255", "species_30389", "P34578", "WBGene00004255" ] }, "reaction_10520163": { "compartment": "compartment_876", "id": "reaction_10520163", "reactome": "R-CEL-381713", "name": "Potassium voltage-gated channels close in reponse to PKA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10520161" ], "products": [ "species_10520161" ], "modifiers": [ [ "species_10508954", "catalyst" ] ], "additional_components": [ "A0A4V0INI0", "WBGene00002242", "H2KZQ6", "WBGene00001374", "J3K003", "WBGene00007862", "Q20381", "WBGene00018402", "Q9XXD1", "WBGene00012967", "U4PLR3", "WBGene00021948", "A0A3B1E007", "WBGene00004793", "G5EC00", "WBGene00008819", "G5EFC3", "WBGene00001202", "A0A4V0INI0", "WBGene00002242", "H2KZQ6", "WBGene00001374", "J3K003", "WBGene00007862", "Q20381", "WBGene00018402", "Q9XXD1", "WBGene00012967", "U4PLR3", "WBGene00021948", "A0A3B1E007", "WBGene00004793", "G5EC00", "WBGene00008819", "G5EFC3", "WBGene00001202", "WBGene00002189" ] }, "reaction_10520051": { "compartment": "compartment_876", "id": "reaction_10520051", "reactome": "R-CEL-381608", "name": "cAMP activates EPAC2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10520047", "species_30389" ], "products": [ "species_10520049" ], "modifiers": [], "additional_components": [ "WBGene00004255", "species_30389", "P34578", "WBGene00004255" ] }, "reaction_10520167": { "compartment": "compartment_70101", "id": "reaction_10520167", "reactome": "R-CEL-381727", "name": "RAP1A exchanges GDP for GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10520165" ], "products": [ "species_29420", "species_10518164" ], "modifiers": [ [ "species_10520049", "catalyst" ], [ "species_10520080", "catalyst" ] ], "additional_components": [ "Q18246", "WBGene00004307", "species_29420", "Q18246", "WBGene00004307", "species_29438", "species_30389", "P34578", "WBGene00004255", "species_30389", "P34578", "WBGene00004255" ] }, "reaction_10520075": { "compartment": "compartment_12045", "id": "reaction_10520075", "reactome": "R-CEL-381644", "name": "ER calcium channels open in response to activated PKA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10520065" ], "products": [ "species_10520073" ], "modifiers": [ [ "species_10508954", "catalyst" ] ], "additional_components": [ "Q9Y0A1", "WBGene00002173", "Q9Y0A1", "WBGene00002173", "species_114520", "WBGene00002189" ] }, "reaction_10507009": { "compartment": "compartment_350", "id": "reaction_10507009", "reactome": "R-CEL-74986", "name": "Elongation of pre-rRNA transcript", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74985", "species_30595" ], "products": [ "species_74985" ], "modifiers": [ [ "species_10506322", "catalyst" ], [ "species_10507007", "catalyst" ] ], "additional_components": [ "species_110614", "species_29358", "species_29494", "species_29438", "P46064", "WBGene00006430", "O01914", "WBGene00017758", "P32085", "WBGene00006542", "Q19826", "WBGene00017830", "Q9UAY9", "WBGene00019275", "Q9U3I0", "WBGene00009078", "G5ED21", "WBGene00012999", "Q9N5K2", "WBGene00019246", "Q95X83", "WBGene00017749", "Q17684", "WBGene00007355", "Q9GR61", "WBGene00021347", "O17587", "WBGene00007616", "Q27493", "WBGene00008781", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "P34618", "WBGene00000414", "P62784", "WBGene00001875", "K7ZUH9", "WBGene00001914", "Q10453", "WBGene00001945" ] }, "reaction_10506324": { "compartment": "compartment_7660", "id": "reaction_10506324", "reactome": "R-CEL-73769", "name": "Loss of Rrn3 from RNA Polymerase I promoter escape complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10506318" ], "products": [ "species_10506238", "species_10506322" ], "modifiers": [], "additional_components": [ "Q19826", "WBGene00017830", "Q9UAY9", "WBGene00019275", "Q9U3I0", "WBGene00009078", "G5ED21", "WBGene00012999", "Q9N5K2", "WBGene00019246", "Q95X83", "WBGene00017749", "Q17684", "WBGene00007355", "Q9GR61", "WBGene00021347", "O17587", "WBGene00007616", "Q27493", "WBGene00008781", "P48322", "WBGene00007980", "P46064", "WBGene00006430", "O01914", "WBGene00017758", "P32085", "WBGene00006542", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "WBGene00007980", "P46064", "WBGene00006430", "O01914", "WBGene00017758", "P32085", "WBGene00006542", "Q19826", "WBGene00017830", "Q9UAY9", "WBGene00019275", "Q9U3I0", "WBGene00009078", "G5ED21", "WBGene00012999", "Q9N5K2", "WBGene00019246", "Q95X83", "WBGene00017749", "Q17684", "WBGene00007355", "Q9GR61", "WBGene00021347", "O17587", "WBGene00007616", "Q27493", "WBGene00008781", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529" ] }, "reaction_10506242": { "compartment": "compartment_7660", "id": "reaction_10506242", "reactome": "R-CEL-73757", "name": "Binding of RRN3 to RNA Polymerase I", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10506238", "species_10506233" ], "products": [ "species_10506240" ], "modifiers": [], "additional_components": [ "WBGene00007980", "Q19826", "WBGene00017830", "Q9UAY9", "WBGene00019275", "Q9U3I0", "WBGene00009078", "G5ED21", "WBGene00012999", "Q9N5K2", "WBGene00019246", "Q95X83", "WBGene00017749", "Q17684", "WBGene00007355", "Q9GR61", "WBGene00021347", "O17587", "WBGene00007616", "Q27493", "WBGene00008781", "Q19826", "WBGene00017830", "Q9UAY9", "WBGene00019275", "Q9U3I0", "WBGene00009078", "G5ED21", "WBGene00012999", "Q9N5K2", "WBGene00019246", "Q95X83", "WBGene00017749", "Q17684", "WBGene00007355", "Q9GR61", "WBGene00021347", "O17587", "WBGene00007616", "Q27493", "WBGene00008781", "P48322", "WBGene00007980" ] }, "reaction_10544853": { "compartment": "compartment_876", "id": "reaction_10544853", "reactome": "R-CEL-2534365", "name": "Slo3 Potassium Transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10544850", "catalyst" ] ], "additional_components": [ "Q95V25", "WBGene00004830" ] }, "reaction_10544843": { "compartment": "compartment_876", "id": "reaction_10544843", "reactome": "R-CEL-2534346", "name": "SPAM1 Binds Hyaluronic Acid", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10544839", "species_1297302" ], "products": [ "species_10544841" ], "modifiers": [], "additional_components": [ "WBGene00011923", "species_1297302", "G5ECE8", "WBGene00011923" ] }, "reaction_10568369": { "compartment": "compartment_161320", "id": "reaction_10568369", "reactome": "R-CEL-8938108", "name": "SERPINB13 binds cathepsin L", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10568365", "species_10568363" ], "products": [ "species_10568367" ], "modifiers": [], "additional_components": [ "Q93512", "WBGene00019986", "O45734", "WBGene00000776", "Q23030", "WBGene00019986", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "A9Z1L1", "WBGene00005648", "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "A9Z1L1", "WBGene00005648", "G5ECY2", "WBGene00005644", "Q93512", "WBGene00019986", "O45734", "WBGene00000776", "Q23030", "WBGene00019986" ] }, "reaction_10568373": { "compartment": "compartment_161320", "id": "reaction_10568373", "reactome": "R-CEL-8938121", "name": "SERPINB13 binds CTSK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10568363", "species_10542848" ], "products": [ "species_10568371" ], "modifiers": [], "additional_components": [ "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "A9Z1L1", "WBGene00005648", "G5ECY2", "WBGene00005644", "O45734", "WBGene00000776", "Q23030", "WBGene00019986", "Q93512", "WBGene00019986", "O45734", "WBGene00000776", "Q23030", "WBGene00019986", "Q93512", "WBGene00019986", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "A9Z1L1", "WBGene00005648", "G5ECY2", "WBGene00005644" ] }, "reaction_10573076": { "compartment": "compartment_459", "id": "reaction_10573076", "reactome": "R-CEL-9674531", "name": "AAMP binds EGFR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10512185", "species_10573072" ], "products": [ "species_10573074" ], "modifiers": [], "additional_components": [ "WBGene00002299", "WBGene00013735", "E0R7L2", "WBGene00013735", "P24348", "WBGene00002299" ] }, "reaction_10512180": { "compartment": "compartment_70101", "id": "reaction_10512180", "reactome": "R-CEL-177938", "name": "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10512175", "species_29438" ], "products": [ "species_29420", "species_10511481" ], "modifiers": [ [ "species_10512177", "catalyst" ] ], "additional_components": [ "species_29420", "P22981", "WBGene00002335", "species_29438", "P22981", "WBGene00002335", "P24348", "WBGene00002299", "P29355", "WBGene00004774", "Q9N5D3", "WBGene00004947" ] }, "reaction_10508553": { "compartment": "compartment_70101", "id": "reaction_10508553", "reactome": "R-CEL-109813", "name": "GRB2-1 binds SOS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10506876", "species_10506871" ], "products": [ "species_10506878" ], "modifiers": [], "additional_components": [ "WBGene00004947", "WBGene00004774", "P29355", "WBGene00004774", "Q9N5D3", "WBGene00004947" ] }, "reaction_10502745": { "compartment": "compartment_70101", "id": "reaction_10502745", "reactome": "R-CEL-69191", "name": "Formation of Cyclin E:Cdk2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502739", "species_10502737" ], "products": [ "species_10502743" ], "modifiers": [], "additional_components": [ "WBGene00000871", "WBGene00019362", "O61847", "WBGene00019362", "O01501", "WBGene00000871" ] }, "reaction_10509929": { "compartment": "compartment_13231", "id": "reaction_10509929", "reactome": "R-CEL-157906", "name": "Translocation of Cyclin E:Cdk2 complex to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502743" ], "products": [ "species_10502749" ], "modifiers": [], "additional_components": [ "O61847", "WBGene00019362", "O01501", "WBGene00000871", "O61847", "WBGene00019362" ] }, "reaction_10502762": { "compartment": "compartment_7660", "id": "reaction_10502762", "reactome": "R-CEL-69199", "name": "Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10502754" ], "products": [ "species_113550", "species_10502749" ], "modifiers": [ [ "species_10502759", "catalyst" ] ], "additional_components": [ "O01501", "WBGene00000871", "O61847", "WBGene00019362", "O61847", "WBGene00019362", "WBGene00000389" ] }, "reaction_10512702": { "compartment": "compartment_7660", "id": "reaction_10512702", "reactome": "R-CEL-188350", "name": "CAK-mediated phosphorylation of Cyclin E:Cdk2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10502749" ], "products": [ "species_113582", "species_10502596" ], "modifiers": [ [ "species_10506279", "catalyst" ] ], "additional_components": [ "O61847", "WBGene00019362", "O01501", "WBGene00000871", "O61847", "WBGene00019362", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408" ] }, "reaction_10546481": { "compartment": "compartment_70101", "id": "reaction_10546481", "reactome": "R-CEL-3204303", "name": "MRE11 binds cytosolic DNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546477", "species_874088" ], "products": [ "species_10546479" ], "modifiers": [], "additional_components": [ "WBGene00003405", "species_874088", "Q23255", "WBGene00003405" ] }, "reaction_10546391": { "compartment": "compartment_70101", "id": "reaction_10546391", "reactome": "R-CEL-3134946", "name": "DDX41 ubiquitination by TRIM21", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546380", "species_10502375", "species_10530724" ], "products": [ "species_10546388" ], "modifiers": [ [ "species_10530724", "catalyst" ] ], "additional_components": [ "WBGene00019245", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "WBGene00021640", "Q9N3T6", "WBGene00021640", "Q9N5K1", "WBGene00019245", "WBGene00021640" ] }, "reaction_10571225": { "compartment": "compartment_70101", "id": "reaction_10571225", "reactome": "R-CEL-9013869", "name": "DDX41 binds bacterial c-di-AMP, c-di-GMP ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546380", "species_8982080" ], "products": [ "species_10571223" ], "modifiers": [], "additional_components": [ "WBGene00019245", "CHEBI:49537", "CHEBI:47037", "CHEBI:49537", "CHEBI:47037", "Q9N5K1", "WBGene00019245" ] }, "reaction_10513873": { "compartment": "compartment_876", "id": "reaction_10513873", "reactome": "R-CEL-198314", "name": "DAG stimulates protein kinase C-delta", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10513858" ], "products": [ "species_10513870", "species_29370" ], "modifiers": [ [ "species_10513858", "catalyst" ], [ "species_112275", "catalyst" ] ], "additional_components": [ "P34885", "WBGene00004032", "P34722", "WBGene00006599", "P34722", "WBGene00006599", "P34885", "WBGene00004032", "P34885", "WBGene00004032", "P34722", "WBGene00006599" ] }, "reaction_10542115": { "compartment": "compartment_876", "id": "reaction_10542115", "reactome": "R-CEL-2029475", "name": "Production of AA by iPLA2 upon FCGR activation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_426925" ], "products": [ "species_140356", "species_428981" ], "modifiers": [ [ "species_10534904", "catalyst" ] ], "additional_components": [ "WBGene00016661" ] }, "reaction_10542106": { "compartment": "compartment_876", "id": "reaction_10542106", "reactome": "R-CEL-2029471", "name": "Hydrolysis of PC to PA by PLD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_429802", "species_29356" ], "products": [ "species_264618", "species_1602448" ], "modifiers": [ [ "species_10542103", "catalyst" ] ], "additional_components": [ "G5EDU3", "WBGene00004040" ] }, "reaction_10541996": { "compartment": "compartment_70101", "id": "reaction_10541996", "reactome": "R-CEL-2029454", "name": "Autophosphorylation of PAK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10541994", "species_113592" ], "products": [ "species_29370", "species_10520664", "species_10521268" ], "modifiers": [ [ "species_10520670", "catalyst" ] ], "additional_components": [ "species_29438", "Q03206", "ced-10", "Q05062", "WBGene00000390", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "species_29438", "Q03206", "ced-10", "Q05062", "WBGene00000390", "Q17850", "WBGene00003911", "G5EGQ3", "WBGene00003144", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911" ] }, "reaction_10530663": { "compartment": "compartment_876", "id": "reaction_10530663", "reactome": "R-CEL-981539", "name": "C3b binds to cell surface", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10510806", "species_983438" ], "products": [ "species_10530661" ], "modifiers": [], "additional_components": [ "K8F7Z5", "WBGene00008735", "Q7YTU0", "WBGene00013969", "K8F7Z5", "WBGene00008735", "Q7YTU0", "WBGene00013969" ] }, "reaction_10511597": { "compartment": "compartment_984", "id": "reaction_10511597", "reactome": "R-CEL-173739", "name": "Spontaneous hydrolysis of C3 thioester", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10510798", "species_109276" ], "products": [ "species_10511595" ], "modifiers": [], "additional_components": [ "K8F7Z5", "WBGene00008735", "Q7YTU0", "WBGene00013969", "K8F7Z5", "WBGene00008735", "Q7YTU0", "WBGene00013969" ] }, "reaction_10530687": { "compartment": "compartment_876", "id": "reaction_10530687", "reactome": "R-CEL-981713", "name": "C4b binds to cell surface", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_983438", "species_10510784" ], "products": [ "species_10530685" ], "modifiers": [], "additional_components": [ "K8F7Z5", "WBGene00008735", "Q7YTU0", "WBGene00013969", "K8F7Z5", "WBGene00008735", "Q7YTU0", "WBGene00013969" ] }, "reaction_10569040": { "compartment": "compartment_876", "id": "reaction_10569040", "reactome": "R-CEL-8951486", "name": "CD46 binds C4b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10530685", "species_10531687" ], "products": [ "species_10569038" ], "modifiers": [], "additional_components": [ "K8F7Z5", "WBGene00008735", "Q7YTU0", "WBGene00013969", "A0A1N7SYP5", "WBGene00009500", "Q18849", "WBGene00009500", "Q22328", "WBGene00002976", "A0A1N7SYP5", "WBGene00009500", "Q18849", "WBGene00009500", "Q22328", "WBGene00002976", "K8F7Z5", "WBGene00008735", "Q7YTU0", "WBGene00013969" ] }, "reaction_10531691": { "compartment": "compartment_876", "id": "reaction_10531691", "reactome": "R-CEL-1006143", "name": "CD46 binds C3b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10531687", "species_10530661" ], "products": [ "species_10531689" ], "modifiers": [], "additional_components": [ "A0A1N7SYP5", "WBGene00009500", "Q18849", "WBGene00009500", "Q22328", "WBGene00002976", "K8F7Z5", "WBGene00008735", "Q7YTU0", "WBGene00013969", "K8F7Z5", "WBGene00008735", "Q7YTU0", "WBGene00013969", "A0A1N7SYP5", "WBGene00009500", "Q18849", "WBGene00009500", "Q22328", "WBGene00002976" ] }, "reaction_10565402": { "compartment": "compartment_984", "id": "reaction_10565402", "reactome": "R-CEL-8852809", "name": "CPN, CPB2 cleave C3a, C5a", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10565379" ], "products": [ "species_10565381" ], "modifiers": [ [ "species_10565399", "catalyst" ] ], "additional_components": [ "K8F7Z5", "WBGene00008735", "Q7YTU0", "WBGene00013969", "K8F7Z5", "WBGene00008735", "Q7YTU0", "WBGene00013969", "Q22825", "WBGene00012073", "O17754", "WBGene00001189", "Q9N5Z3", "WBGene00006593", "Q9TZC6", "WBGene00021984", "G3MU29", "WBGene00021984", "Q9XU75", "WBGene00011235", "G5EC13", "WBGene00021984", "G5EC96", "WBGene00021984", "H2L0D7", "WBGene00021984", "H2L0K5", "WBGene00021984", "Q6A577", "WBGene00021984", "Q9BL88", "WBGene00021984" ] }, "reaction_10545918": { "compartment": "compartment_984", "id": "reaction_10545918", "reactome": "R-CEL-2855047", "name": "Hydrolysis of internal thioester in C4b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_10510784" ], "products": [ "species_10530671" ], "modifiers": [], "additional_components": [ "K8F7Z5", "WBGene00008735", "Q7YTU0", "WBGene00013969", "K8F7Z5", "WBGene00008735", "Q7YTU0", "WBGene00013969" ] }, "reaction_10529380": { "compartment": "compartment_70101", "id": "reaction_10529380", "reactome": "R-CEL-936563", "name": "ISGylation of DDX58", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10529344", "species_10529376" ], "products": [ "species_10529378" ], "modifiers": [], "additional_components": [ "WBGene00008400", "P91057", "WBGene00015842", "Q9BL11", "WBGene00021685", "Q21633", "WBGene00006713", "Q27481", "WBGene00006699", "P91057", "WBGene00015842", "Q9BL11", "WBGene00021685", "Q21633", "WBGene00006713", "Q27481", "WBGene00006699", "Q93413", "WBGene00008400" ] }, "reaction_10529352": { "compartment": "compartment_70101", "id": "reaction_10529352", "reactome": "R-CEL-936390", "name": "CYLD mediated deubiquitination of DDX58 (RIG-I)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10529342" ], "products": [ "species_10502375", "species_10529344" ], "modifiers": [ [ "species_10529349", "catalyst" ] ], "additional_components": [ "WBGene00008400", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "WBGene00008400", "WBGene00009594" ] }, "reaction_10515197": { "compartment": "compartment_70101", "id": "reaction_10515197", "reactome": "R-CEL-202164", "name": "Translocation of PDK1 to Plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10515193", "species_202277" ], "products": [ "species_10515195" ], "modifiers": [], "additional_components": [ "WBGene00021022", "species_202247", "species_179838", "Q9UA62", "WBGene00021022", "species_202247", "species_179838" ] }, "reaction_10515220": { "compartment": "compartment_70101", "id": "reaction_10515220", "reactome": "R-CEL-202328", "name": "Translocation of PKC theta to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10514851", "species_112275" ], "products": [ "species_10515218" ], "modifiers": [], "additional_components": [ "WBGene00006599", "P34722", "WBGene00006599", "species_112275" ] }, "reaction_10545484": { "compartment": "compartment_70101", "id": "reaction_10545484", "reactome": "R-CEL-2730835", "name": "Autophosphorylation of PKC-theta", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10515204" ], "products": [ "species_10545482", "species_29370" ], "modifiers": [], "additional_components": [ "P34722", "WBGene00006599", "species_112275", "species_112275", "P34722", "WBGene00006599" ] }, "reaction_10545501": { "compartment": "compartment_876", "id": "reaction_10545501", "reactome": "R-CEL-2730862", "name": "Autophosphorylation of LYN kinase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10545490" ], "products": [ "species_10545498", "species_29370" ], "modifiers": [ [ "species_10545490", "catalyst" ] ], "additional_components": [ "Q9N3S5", "WBGene00021635", "G5EE56", "WBGene00005077", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q9N3S5", "WBGene00021635", "G5EE56", "WBGene00005077" ] }, "reaction_10560563": { "compartment": "compartment_6799713", "id": "reaction_10560563", "reactome": "R-CEL-6798747", "name": "Exocytosis of tertiary granule membrane proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10560495" ], "products": [ "species_10560561" ], "modifiers": [], "additional_components": [ "G5EE29", "WBGene00021404", "P91448", "WBGene00004149", "Q19377", "WBGene00008731", "Q23141", "WBGene00020972", "A5PEW5", "WBGene00004364", "G5EEN8", "WBGene00006454", "Q20325", "WBGene00018344", "Q9XUK8", "WBGene00012275", "Q19958", "WBGene00006064", "A0AAC1", "WBGene00012424", "Q21557", "WBGene00010888", "Q22799", "WBGene00001005", "Q65XS9", "WBGene00043067", "Q7YTJ8", "WBGene00012425", "A0A1D3PCM0", "WBGene00270320", "G5EDW5", "WBGene00000074", "G5EFD5", "WBGene00006804", "Q19844", "WBGene00270320", "G5EBK2", "WBGene00014084", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q19767", "WBGene00004898", "Q94057", "WBGene00044062", "Q95XH1", "WBGene00022077", "G5EFD9", "WBGene00006324", "Q9TYL9", "WBGene00021292", "Q9XTY9", "WBGene00010993", "O18076", "WBGene00011668", "O44871", "WBGene00019914", "P91214", "WBGene00017199", "Q21146", "WBGene00019328", "Q9N4W4", "WBGene00021602", "Q9N4W5", "WBGene00021603", "G5EDU3", "WBGene00004040", "U4PBV8", "WBGene00019166", "C0HLB3", "WBGene00006911", "C0HLB4", "WBGene00006912", "Q20707", "WBGene00006630", "G4RWX0", "WBGene00006632", "H2L006", "WBGene00006640", "Q22495", "WBGene00006638", "O62466", "WBGene00006631", "G5ECY2", "WBGene00005644", "Q9NEI8", "WBGene00043980", "A0A0S4XR36", "C44E4.1d", "P22981", "WBGene00002335", "Q27874", "WBGene00003930", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "O17599", "WBGene00004308", "Q93874", "WBGene00004276", "O01312", "WBGene00004309", "Q21433", "WBGene00004877", "Q21434", "WBGene00004876", "Q95XG8", "WBGene00004878", "Q23022", "WBGene00006774", "P34446", "WBGene00003929", "C0HLB4", "WBGene00006912", "C0HLB3", "WBGene00006911", "U4PBV8", "WBGene00019166", "Q22799", "WBGene00001005", "Q65XS9", "WBGene00043067", "Q7YTJ8", "WBGene00012425", "A0AAC1", "WBGene00012424", "Q21557", "WBGene00010888", "Q19377", "WBGene00008731", "Q23141", "WBGene00020972", "G5EE29", "WBGene00021404", "P91448", "WBGene00004149", "O18076", "WBGene00011668", "O44871", "WBGene00019914", "P91214", "WBGene00017199", "Q21146", "WBGene00019328", "Q9N4W4", "WBGene00021602", "Q9N4W5", "WBGene00021603", "Q21433", "WBGene00004877", "Q21434", "WBGene00004876", "Q95XG8", "WBGene00004878", "Q9TYL9", "WBGene00021292", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "Q9XTY9", "WBGene00010993", "P22981", "WBGene00002335", "Q93874", "WBGene00004276", "Q19958", "WBGene00006064", "Q23022", "WBGene00006774", "G5ECY2", "WBGene00005644", "O17599", "WBGene00004308", "O01312", "WBGene00004309", "Q9NEI8", "WBGene00043980", "Q95XH1", "WBGene00022077", "G5EBK2", "WBGene00014084", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q19767", "WBGene00004898", "Q94057", "WBGene00044062", "G5EEN8", "WBGene00006454", "A5PEW5", "WBGene00004364", "Q19844", "WBGene00270320", "A0A1D3PCM0", "WBGene00270320", "G5EDW5", "WBGene00000074", "G5EFD5", "WBGene00006804", "O62466", "WBGene00006631", "Q20707", "WBGene00006630", "Q22495", "WBGene00006638", "G4RWX0", "WBGene00006632", "H2L006", "WBGene00006640", "G5EFD9", "WBGene00006324", "G5EDU3", "WBGene00004040", "Q27874", "WBGene00003930", "P34446", "WBGene00003929", "Q20325", "WBGene00018344", "Q9XUK8", "WBGene00012275", "A0A0S4XR36", "C44E4.1d" ] }, "reaction_10561604": { "compartment": "compartment_1470028", "id": "reaction_10561604", "reactome": "R-CEL-6798751", "name": "Exocytosis of azurophil granule lumen proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10559966" ], "products": [ "species_10560050" ], "modifiers": [], "additional_components": [ "G5EFI4", "WBGene00002268", "A0A486WWU7", "WBGene00000110", "O44555", "WBGene00000111", "Q965W1", "WBGene00021486", "G5ED36", "WBGene00004378", "A0A1N7SYP5", "WBGene00009500", "Q18849", "WBGene00009500", "Q22328", "WBGene00002976", "O62403", "WBGene00013782", "Q20748", "WBGene00010015", "P30628", "WBGene00006768", "O17772", "WBGene00003980", "P34446", "WBGene00003929", "G5ECY2", "WBGene00005644", "Q03206", "ced-10", "G5ED34", "WBGene00001007", "Q94148", "WBGene00004273", "Q19479", "WBGene00008848", "Q7JP75", "WBGene00000872", "E6N0V1", "WBGene00018819", "Q8MXS1", "WBGene00004277", "G5ECX0", "WBGene00002252", "Q94986", "WBGene00004267", "P55163", "WBGene00001580", "P91857", "WBGene00004268", "Q22601", "WBGene00000161", "Q9NEI8", "WBGene00043980", "P34213", "WBGene00004269", "Q22782", "WBGene00004270", "A9Z1L1", "WBGene00005648", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "Q23146", "WBGene00004271", "Q22038", "WBGene00004357", "Q18673", "WBGene00013926", "P91214", "WBGene00017199", "Q21146", "WBGene00019328", "Q9N4W4", "WBGene00021602", "Q9N4W5", "WBGene00021603", "O18076", "WBGene00011668", "O44871", "WBGene00019914", "Q22531", "WBGene00011803", "Q9TYL9", "WBGene00021292", "O62403", "WBGene00013782", "Q94148", "WBGene00004273", "Q8MXS1", "WBGene00004277", "P91857", "WBGene00004268", "P34213", "WBGene00004269", "Q22782", "WBGene00004270", "O18076", "WBGene00011668", "O44871", "WBGene00019914", "P91214", "WBGene00017199", "Q21146", "WBGene00019328", "Q9N4W4", "WBGene00021602", "Q9N4W5", "WBGene00021603", "Q23146", "WBGene00004271", "Q9TYL9", "WBGene00021292", "Q22038", "WBGene00004357", "Q965W1", "WBGene00021486", "Q22531", "WBGene00011803", "Q20748", "WBGene00010015", "Q22328", "WBGene00002976", "A0A1N7SYP5", "WBGene00009500", "Q18849", "WBGene00009500", "P30628", "WBGene00006768", "A0A486WWU7", "WBGene00000110", "O44555", "WBGene00000111", "G5ECY2", "WBGene00005644", "G5ED34", "WBGene00001007", "Q9NEI8", "WBGene00043980", "Q19479", "WBGene00008848", "Q7JP75", "WBGene00000872", "E6N0V1", "WBGene00018819", "P55163", "WBGene00001580", "P34446", "WBGene00003929", "O17772", "WBGene00003980", "Q03206", "ced-10", "G5ED36", "WBGene00004378", "Q19651", "WBGene00005649", "A9Z1L1", "WBGene00005648", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q22601", "WBGene00000161", "G5ECX0", "WBGene00002252", "Q94986", "WBGene00004267", "Q18673", "WBGene00013926", "G5EFI4", "WBGene00002268" ] }, "reaction_10559815": { "compartment": "compartment_6798757", "id": "reaction_10559815", "reactome": "R-CEL-6798739", "name": "Exocytosis of azurophil granule membrane proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10559673" ], "products": [ "species_10559813" ], "modifiers": [], "additional_components": [ "Q22630", "WBGene00011879", "E7EM30", "WBGene00206373", "Q19175", "WBGene00008560", "O17373", "WBGene00020471", "Q23534", "WBGene00022770", "Q19390", "WBGene00017427", "Q95PW2", "WBGene00206373", "P90949", "WBGene00011262", "Q19460", "WBGene00008801", "Q09448", "WBGene00007328", "Q95QK6", "WBGene00008804", "Q19461", "WBGene00008802", "Q9BL40", "WBGene00022181", "Q09451", "WBGene00007331", "Q20662", "WBGene00018696", "A0A061AJ50", "WBGene00206373", "Q10944", "WBGene00015161", "E7EM29", "WBGene00016152", "Q9GUF1", "WBGene00022246", "Q22525", "WBGene00004023", "Q9GUF2", "WBGene00022245", "Q19076", "WBGene00004020", "Q94986", "WBGene00004267", "Q95XH1", "WBGene00022077", "G5EBK2", "WBGene00014084", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q19767", "WBGene00004898", "Q94057", "WBGene00044062", "Q01608", "WBGene00004958", "O02100", "WBGene00001985", "P52166", "WBGene00004769", "Q9XXA4", "WBGene00007067", "Q19958", "WBGene00006064", "P91857", "WBGene00004268", "Q9U280", "WBGene00013034", "P34676", "WBGene00022801", "Q18864", "WBGene00004788", "G5EDC6", "WBGene00000192", "Q18276", "WBGene00004995", "Q18246", "WBGene00004307", "O76735", "WBGene00004912", "Q11117", "WBGene00003053", "Q9GYK0", "WBGene00015471", "H2KZR1", "WBGene00019780", "P83386", "WBGene00019780", "Q21228", "WBGene00019780", "D9N147", "WBGene00019780", "P83387", "WBGene00019780", "Q18582", "WBGene00019780", "P83351", "WBGene00019305", "G5ED36", "WBGene00004378", "E5QCE7", "WBGene00001032", "Q95QX5", "WBGene00015561", "P45971", "WBGene00011638", "C0HLB3", "WBGene00006911", "C0HLB4", "WBGene00006912", "Q93324", "WBGene00007904", "O76663", "WBGene00015246", "P34669", "WBGene00022793", "P91245", "WBGene00017385", "Q9BL33", "WBGene00022169", "Q23316", "WBGene00000148", "Q9XWC5", "WBGene00019346", "Q23151", "WBGene00012224", "H2L0H3", "WBGene00019946", "Q19635", "WBGene00008969", "Q17441", "WBGene00006646", "C0HLB4", "WBGene00006912", "C0HLB3", "WBGene00006911", "P52166", "WBGene00004769", "Q01608", "WBGene00004958", "O02100", "WBGene00001985", "Q9XWC5", "WBGene00019346", "H2L0H3", "WBGene00019946", "Q19635", "WBGene00008969", "Q23151", "WBGene00012224", "G5EDC6", "WBGene00000192", "Q9GYK0", "WBGene00015471", "Q11117", "WBGene00003053", "E5QCE7", "WBGene00001032", "P34669", "WBGene00022793", "Q19958", "WBGene00006064", "Q9U280", "WBGene00013034", "P91245", "WBGene00017385", "Q17441", "WBGene00006646", "Q93324", "WBGene00007904", "Q09448", "WBGene00007328", "Q9GUF2", "WBGene00022245", "Q09451", "WBGene00007331", "Q10944", "WBGene00015161", "Q19076", "WBGene00004020", "Q19175", "WBGene00008560", "Q19390", "WBGene00017427", "Q19460", "WBGene00008801", "Q19461", "WBGene00008802", "Q20662", "WBGene00018696", "Q22525", "WBGene00004023", "Q22630", "WBGene00011879", "A0A061AJ50", "WBGene00206373", "Q23534", "WBGene00022770", "E7EM29", "WBGene00016152", "Q95PW2", "WBGene00206373", "E7EM30", "WBGene00206373", "Q95QK6", "WBGene00008804", "O17373", "WBGene00020471", "Q9BL40", "WBGene00022181", "P90949", "WBGene00011262", "Q9GUF1", "WBGene00022246", "Q95XH1", "WBGene00022077", "G5EBK2", "WBGene00014084", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q19767", "WBGene00004898", "Q94057", "WBGene00044062", "P34676", "WBGene00022801", "Q23316", "WBGene00000148", "Q18276", "WBGene00004995", "D9N147", "WBGene00019780", "H2KZR1", "WBGene00019780", "P83386", "WBGene00019780", "P83387", "WBGene00019780", "Q18582", "WBGene00019780", "Q21228", "WBGene00019780", "P45971", "WBGene00011638", "G5ED36", "WBGene00004378", "Q94986", "WBGene00004267", "O76663", "WBGene00015246", "Q9XXA4", "WBGene00007067", "Q18246", "WBGene00004307", "Q9BL33", "WBGene00022169", "P91857", "WBGene00004268", "Q18864", "WBGene00004788", "P83351", "WBGene00019305", "O76735", "WBGene00004912", "Q95QX5", "WBGene00015561" ] }, "reaction_10562822": { "compartment": "compartment_984", "id": "reaction_10562822", "reactome": "R-CEL-6800434", "name": "Exocytosis of ficolin-rich granule lumen proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10562768" ], "products": [ "species_10562820" ], "modifiers": [], "additional_components": [ "O45686", "WBGene00010769", "Q27483", "WBGene00008230", "Q9TZL8", "WBGene00022199", "Q21966", "WBGene00000217", "P43510", "WBGene00000786", "Q8MYL7", "WBGene00013220", "O62334", "WBGene00011050", "Q18688", "WBGene00000915", "P28548", "WBGene00002196", "O61792", "WBGene00004464", "P09446", "WBGene00002005", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "P04630", "WBGene00000285", "Q09665", "WBGene00006583", "A0A2C9C3L3", "WBGene00020378", "Q09980", "WBGene00017394", "G5EDZ8", "WBGene00000288", "Q11083", "WBGene00020378", "G5EEG0", "WBGene00000286", "Q18136", "WBGene00006861", "G5EF37", "WBGene00003934", "Q94288", "WBGene00000287", "Q20585", "WBGene00004463", "G5EC99", "WBGene00009691", "G5ECU5", "WBGene00009691", "O45246", "WBGene00002026", "Q04908", "WBGene00004460", "Q9GZH5", 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"WBGene00011050", "O61792", "WBGene00004464", "Q20585", "WBGene00004463" ] }, "reaction_10561224": { "compartment": "compartment_6799371", "id": "reaction_10561224", "reactome": "R-CEL-6798749", "name": "Exocytosis of specific granule lumen proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10561178" ], "products": [ "species_10561222" ], "modifiers": [], "additional_components": [ "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "Q21182", "WBGene00194737", "O61967", "WBGene00002632", "Q21408", "WBGene00004951", "O44131", "WBGene00015620", "G5EBT7", "WBGene00000583", "G5EGP1", "WBGene00006845", "Q19137", "WBGene00008543", "G5EFB5", "WBGene00000777", "G5EC24", "WBGene00004214", "O01824", "WBGene00019008", "G5EBS5", "WBGene00000089", "Q19202", "WBGene00017244", "Q10953", "WBGene00006943", "Q18825", "WBGene00000238", "O44326", "WBGene00001979", "H2KZY5", "WBGene00018533", "Q11174", "WBGene00000503", "Q93565", "WBGene00006578", "P19826", "WBGene00000942", "O44518", "WBGene00001579", "Q19349", "WBGene00017376", "Q966Q0", "WBGene00017376", "G5EBT9", "WBGene00010418", "Q9N5N3", "WBGene00019178", "G5EEN3", "WBGene00000419", "O45539", "WBGene00005078", "Q10011", "WBGene00020563", "Q304D5", "WBGene00016278", "A0A1X7RC97", "WBGene00020658", "Q9BIB8", "WBGene00002075", "Q21966", "WBGene00000217", "O62349", "WBGene00011253", "Q93377", "WBGene00008093", "Q09498", "WBGene00008051", "Q18740", "WBGene00008231", "Q9U2X1", "WBGene00013764", "Q9XWA4", "WBGene00013764", "Q9XXQ7", "WBGene00013764", "G5EGP8", "WBGene00000788", "P92005", "WBGene00000789", "Q304D5", "WBGene00016278", "Q21182", "WBGene00194737", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "Q9BIB8", "WBGene00002075", "O61967", "WBGene00002632", "G5EBS5", "WBGene00000089", "Q93565", "WBGene00006578", "H2KZY5", "WBGene00018533", "Q21408", "WBGene00004951", "O44518", "WBGene00001579", "P19826", "WBGene00000942", "Q21966", "WBGene00000217", "O44326", "WBGene00001979", "Q10953", "WBGene00006943", "Q18825", "WBGene00000238", "O44131", "WBGene00015620", "O01824", "WBGene00019008", "A0A1X7RC97", "WBGene00020658", "O45539", "WBGene00005078", "G5EBT9", "WBGene00010418", "Q19202", "WBGene00017244", "G5EC24", "WBGene00004214", "Q10011", "WBGene00020563", "Q9XWA4", "WBGene00013764", "Q9XXQ7", "WBGene00013764", "G5EGP8", "WBGene00000788", "P92005", "WBGene00000789", "Q18740", "WBGene00008231", "Q9U2X1", "WBGene00013764", "G5EBT7", "WBGene00000583", "G5EGP1", "WBGene00006845", "Q19137", "WBGene00008543", "Q19349", "WBGene00017376", "Q966Q0", "WBGene00017376", "G5EFB5", "WBGene00000777", "Q9N5N3", "WBGene00019178", "O62349", "WBGene00011253", "Q11174", "WBGene00000503", "Q09498", "WBGene00008051", "Q93377", "WBGene00008093", "G5EEN3", "WBGene00000419" ] }, "reaction_10560312": { "compartment": "compartment_6800173", "id": "reaction_10560312", "reactome": "R-CEL-6798745", "name": "Exocytosis of tertiary granule lumen proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10560232" ], "products": [ "species_10560310" ], "modifiers": [], "additional_components": [ "Q20587", "WBGene00044310", "Q22993", "WBGene00018811", "Q4W5T6", "WBGene00044310", "O62349", "WBGene00011253", "U4PBQ7", "WBGene00015250", "Q20911", "WBGene00013855", "A8WFK8", "WBGene00016619", "O45686", "WBGene00010769", "Q9N5N3", "WBGene00019178", "H2KZY5", "WBGene00018533", "Q19349", "WBGene00017376", "Q966Q0", "WBGene00017376", "Q19202", "WBGene00017244", "Q11174", "WBGene00000503", "G5EC24", "WBGene00004214", "G5EFB5", "WBGene00000777", "Q21408", "WBGene00004951", "O44518", "WBGene00001579", "Q21966", "WBGene00000217", "H9G2T4", "WBGene00010317", "G5EBT9", "WBGene00010418", "O45734", "WBGene00000776", "Q23030", "WBGene00019986", "Q93512", "WBGene00019986", "G5ECM9", "WBGene00000534", "Q9U204", "WBGene00013323", "Q20628", "WBGene00000392", "Q19137", "WBGene00008543", "G5EBT7", "WBGene00000583", "G5EGP1", "WBGene00006845", "Q9XUT0", "WBGene00010664", "O16453", "WBGene00001500", "Q9TYS3", "WBGene00001501", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "Q21182", "WBGene00194737", "P54216", "WBGene00011474", "P46563", "WBGene00017166", "Q21742", "WBGene00019890", "G5EFT4", "WBGene00016589", "Q09498", "WBGene00008051", "Q93377", "WBGene00008093", "G5ECM9", "WBGene00000534", "Q21182", "WBGene00194737", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "Q9XUT0", "WBGene00010664", "O16453", "WBGene00001500", "Q9TYS3", "WBGene00001501", "H2KZY5", "WBGene00018533", "O44518", "WBGene00001579", "Q21408", "WBGene00004951", "O45734", "WBGene00000776", "Q23030", "WBGene00019986", "Q93512", "WBGene00019986", "Q9U204", "WBGene00013323", "G5EFT4", "WBGene00016589", "Q21966", "WBGene00000217", "H9G2T4", "WBGene00010317", "Q21742", "WBGene00019890", "A8WFK8", "WBGene00016619", "Q20911", "WBGene00013855", "Q20587", "WBGene00044310", "Q22993", "WBGene00018811", "Q4W5T6", "WBGene00044310", "G5EBT9", "WBGene00010418", "O45686", "WBGene00010769", "P46563", "WBGene00017166", "P54216", "WBGene00011474", "Q19202", "WBGene00017244", "G5EC24", "WBGene00004214", "Q11174", "WBGene00000503", "U4PBQ7", "WBGene00015250", "G5EBT7", "WBGene00000583", "G5EGP1", "WBGene00006845", "Q19137", "WBGene00008543", "Q19349", "WBGene00017376", "Q966Q0", "WBGene00017376", "G5EFB5", "WBGene00000777", "Q9N5N3", "WBGene00019178", "O62349", "WBGene00011253", "Q09498", "WBGene00008051", "Q93377", "WBGene00008093", "Q20628", "WBGene00000392" ] }, "reaction_10562427": { "compartment": "compartment_6800424", "id": "reaction_10562427", "reactome": "R-CEL-6800426", "name": "Exocytosis of ficolin-rich granule membrane proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10562381" ], "products": [ "species_10562425" ], "modifiers": [], "additional_components": [ "A9Z1L1", "WBGene00005648", "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "Q19479", "WBGene00008848", "Q7JP75", "WBGene00000872", "E6N0V1", "WBGene00018819", "A0A1D3PCM0", "WBGene00270320", "G5EDW5", "WBGene00000074", "G5EFD5", "WBGene00006804", "Q19844", "WBGene00270320", "A0A0S4XR36", "C44E4.1d", "O45359", "WBGene00020195", "Q17540", "WBGene00020195", "Q22129", "WBGene00020195", "G5ECX0", "WBGene00002252", "Q21146", "WBGene00019328", "Q9N4W4", "WBGene00021602", "Q9N4W5", "WBGene00021603", "O18076", "WBGene00011668", "O44871", "WBGene00019914", "P91214", "WBGene00017199", "Q19833", "WBGene00017837", "P55163", "WBGene00001580", "A0A1N7SYP5", "WBGene00009500", "Q18849", "WBGene00009500", "Q22328", "WBGene00002976", "Q27874", "WBGene00003930", "G5EFI4", "WBGene00002268", "C0HLB3", "WBGene00006911", "C0HLB4", "WBGene00006912", "Q03206", "ced-10", "Q22601", "WBGene00000161", "P34676", "WBGene00022801", "Q22038", "WBGene00004357", "G5EGJ5", "WBGene00002048", "Q95XG8", "WBGene00004878", "Q21433", "WBGene00004877", "Q21434", "WBGene00004876", "Q11117", "WBGene00003053", "Q9GYK0", "WBGene00015471", "Q53U87", "WBGene00004732", "G5EDC6", "WBGene00000192", "G5EE29", "WBGene00021404", "P91448", "WBGene00004149", "Q19377", "WBGene00008731", "Q23141", "WBGene00020972", "Q20748", "WBGene00010015", "A0AAC1", "WBGene00012424", "Q21557", "WBGene00010888", "Q22799", "WBGene00001005", "Q65XS9", "WBGene00043067", "Q7YTJ8", "WBGene00012425", "Q9NEI8", "WBGene00043980", "P30628", "WBGene00006768", "Q19319", "WBGene00000396", "B2MZD0", "WBGene00006916", "G5EEK9", "WBGene00006914", "G5EGP4", "WBGene00006915", "Q9U308", "WBGene00002175", "O44873", "WBGene00019915", "P34446", "WBGene00003929", "G5ED34", "WBGene00001007", "Q9TYL9", "WBGene00021292", "Q9XTY9", "WBGene00010993", "A0A1N7SYP3", "WBGene00006876", "C0HLB4", "WBGene00006912", "C0HLB3", "WBGene00006911", "A0A1N7SYP3", "WBGene00006876", "G5EEK9", "WBGene00006914", "G5EGP4", "WBGene00006915", "P30628", "WBGene00006768", "B2MZD0", "WBGene00006916", "Q22799", "WBGene00001005", "Q65XS9", "WBGene00043067", "Q7YTJ8", "WBGene00012425", "A0AAC1", "WBGene00012424", "Q21557", "WBGene00010888", "Q19377", "WBGene00008731", "Q23141", "WBGene00020972", "G5EE29", "WBGene00021404", "P91448", "WBGene00004149", "G5EDC6", "WBGene00000192", "Q22038", "WBGene00004357", "O18076", "WBGene00011668", "O44871", "WBGene00019914", "P91214", "WBGene00017199", "Q21146", "WBGene00019328", "Q9N4W4", "WBGene00021602", "Q9N4W5", "WBGene00021603", "Q21433", "WBGene00004877", "Q21434", "WBGene00004876", "Q95XG8", "WBGene00004878", "Q9TYL9", "WBGene00021292", "Q9XTY9", "WBGene00010993", "Q20748", "WBGene00010015", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "A9Z1L1", "WBGene00005648", "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "Q11117", "WBGene00003053", "Q9GYK0", "WBGene00015471", "G5ED34", "WBGene00001007", "Q19319", "WBGene00000396", "Q9NEI8", "WBGene00043980", "Q19479", "WBGene00008848", "Q7JP75", "WBGene00000872", "E6N0V1", "WBGene00018819", "P55163", "WBGene00001580", "P34676", "WBGene00022801", "Q19844", "WBGene00270320", "A0A1D3PCM0", "WBGene00270320", "G5EDW5", "WBGene00000074", "G5EFD5", "WBGene00006804", "P34446", "WBGene00003929", "Q27874", "WBGene00003930", "Q53U87", "WBGene00004732", "G5EGJ5", "WBGene00002048", "Q03206", "ced-10", "O44873", "WBGene00019915", "Q22601", "WBGene00000161", "G5ECX0", "WBGene00002252", "A0A0S4XR36", "C44E4.1d", "O45359", "WBGene00020195", "Q17540", "WBGene00020195", "Q22129", "WBGene00020195", "A0A1N7SYP5", "WBGene00009500", "Q18849", "WBGene00009500", "Q22328", "WBGene00002976", "Q19833", "WBGene00017837", "Q9U308", "WBGene00002175", "G5EFI4", "WBGene00002268" ] }, "reaction_10562074": { "compartment": "compartment_6799351", "id": "reaction_10562074", "reactome": "R-CEL-6799350", "name": "Exocytosis of specific granule membrane proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10562030" ], "products": [ "species_10562072" ], "modifiers": [], "additional_components": [ "G5EC93", "WBGene00022014", "O16547", "WBGene00022014", "O44616", "WBGene00022014", "O44827", "WBGene00019207", "O45920", "WBGene00022014", "Q11114", "WBGene00022014", "Q19376", "WBGene00022014", "Q20734", "WBGene00022014", "Q23535", "WBGene00006865", "Q23626", "WBGene00022014", "Q95QY6", "WBGene00022014", "Q9GPA2", "WBGene00022014", "Q9N309", "WBGene00022014", "Q9U2K5", "WBGene00022014", "Q9XU83", "WBGene00022014", "Q9XVL3", "WBGene00022014", "G5EED5", "WBGene00004743", "Q9N4W4", "WBGene00021602", "Q9N4W5", "WBGene00021603", "O18076", "WBGene00011668", "O44871", "WBGene00019914", "P91214", "WBGene00017199", "Q21146", "WBGene00019328", "A5PEW5", "WBGene00004364", "Q20325", "WBGene00018344", "Q9XUK8", "WBGene00012275", "G5EGJ9", "WBGene00009717", "Q9NCE1", "WBGene00010408", "G5EEN8", "WBGene00006454", 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"WBGene00012224", "Q20734", "WBGene00022014", "O16547", "WBGene00022014", "Q9XU83", "WBGene00022014", "Q23535", "WBGene00006865", "O44616", "WBGene00022014", "Q9XVL3", "WBGene00022014", "Q23626", "WBGene00022014", "O44827", "WBGene00019207", "Q95QY6", "WBGene00022014", "O45920", "WBGene00022014", "Q9GPA2", "WBGene00022014", "Q11114", "WBGene00022014", "Q9N309", "WBGene00022014", "Q19376", "WBGene00022014", "G5EC93", "WBGene00022014", "Q9U2K5", "WBGene00022014", "Q19377", "WBGene00008731", "Q23141", "WBGene00020972", "G5EE29", "WBGene00021404", "P91448", "WBGene00004149", "Q9N2U6", "WBGene00022402", "Q22267", "WBGene00011543", "Q8WQG5", "WBGene00007390", "P35602", "WBGene00006829", "Q19958", "WBGene00006064", "E5QCE7", "WBGene00001032", "Q23022", "WBGene00006774", "A0A486WWU7", "WBGene00000110", "O44555", "WBGene00000111", "Q9U280", "WBGene00013034", "G5EC63", "WBGene00013197", "O44186", "WBGene00017996", "O01312", "WBGene00004309", "O17599", "WBGene00004308", "Q9NCE1", "WBGene00010408", "G5EGJ9", "WBGene00009717", "Q9NEI8", "WBGene00043980", "Q95XH1", "WBGene00022077", "G5EBK2", "WBGene00014084", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q19767", "WBGene00004898", "Q94057", "WBGene00044062", "Q19878", "WBGene00009218", "Q18916", "WBGene00017012", "G5EEN8", "WBGene00006454", "A5PEW5", "WBGene00004364", "Q19844", "WBGene00270320", "A0A1D3PCM0", "WBGene00270320", "G5EDW5", "WBGene00000074", "G5EFD5", "WBGene00006804", "Q19930", "WBGene00017947", "O62466", "WBGene00006631", "Q20707", "WBGene00006630", "Q22495", "WBGene00006638", "G4RWX0", "WBGene00006632", "H2L006", "WBGene00006640", "Q10956", "WBGene00015148", "G5EFD9", "WBGene00006324", "G5EDU3", "WBGene00004040", "Q95QG1", "WBGene00018423", "Q27874", "WBGene00003930", "A0A4V0IKG6", "WBGene00007287", "D9N147", "WBGene00019780", "H2KZR1", "WBGene00019780", "P83386", "WBGene00019780", "P83387", "WBGene00019780", "Q18582", "WBGene00019780", "Q21228", "WBGene00019780", "Q9XXA4", "WBGene00007067", "Q18246", "WBGene00004307", "Q9N3Y5", "WBGene00021537", "Q20241", "WBGene00006470", "Q8MQ55", "WBGene00009580", "P34462", "WBGene00010130", "Q20325", "WBGene00018344", "Q9XUK8", "WBGene00012275", "G5EED5", "WBGene00004743", "P91214", "WBGene00017199", "Q21146", "WBGene00019328", "Q9N4W4", "WBGene00021602", "Q9N4W5", "WBGene00021603", "O18076", "WBGene00011668", "O44871", "WBGene00019914", "A0A0S4XR36", "C44E4.1d", "P34446", "WBGene00003929", "Q95QX5", "WBGene00015561", "O44836", "WBGene00019212" ] }, "reaction_10552610": { "compartment": "compartment_876", "id": "reaction_10552610", "reactome": "R-CEL-5607746", "name": "PKC-delta is activated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10552599" ], "products": [ "species_10552608" ], "modifiers": [], "additional_components": [ "species_112275", "P34722", "WBGene00006599", "species_112275", "P34722", "WBGene00006599" ] }, "reaction_10552614": { "compartment": "compartment_876", "id": "reaction_10552614", "reactome": "R-CEL-5607755", "name": "p-Y753,Y759-PLCG2 translocates from cytosol to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10552612" ], "products": [ "species_10552603" ], "modifiers": [], "additional_components": [ "WBGene00004038", "WBGene00004038" ] }, "reaction_10552601": { "compartment": "compartment_876", "id": "reaction_10552601", "reactome": "R-CEL-5607734", "name": "PKC-delta translocates to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10550601", "species_112275" ], "products": [ "species_10552599" ], "modifiers": [], "additional_components": [ "WBGene00006599", "species_112275", "P34722", "WBGene00006599" ] }, "reaction_10552606": { "compartment": "compartment_876", "id": "reaction_10552606", "reactome": "R-CEL-5607735", "name": "p-Y753,Y759-PLCG2 hydrolyses PIP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_179856" ], "products": [ "species_114520", "species_112275" ], "modifiers": [ [ "species_10552603", "catalyst" ] ], "additional_components": [ "WBGene00004038" ] }, "reaction_10553376": { "compartment": "compartment_876", "id": "reaction_10553376", "reactome": "R-CEL-5624486", "name": "SFKs phosphorylates RAF1 on Y340,Y341", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10553365" ], "products": [ "species_10553371", "species_29370" ], "modifiers": [ [ "species_10553373", "catalyst" ] ], "additional_components": [ "Q07292", "WBGene00003030", "species_29438", "P22981", "WBGene00002335", "Q07292", "WBGene00003030", "species_29438", "P22981", "WBGene00002335", "Q9N3S5", "WBGene00021635", "G5EE56", "WBGene00005077" ] }, "reaction_10553381": { "compartment": "compartment_876", "id": "reaction_10553381", "reactome": "R-CEL-5624492", "name": "PAK phosphorylates p21 RAF1 on S338", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10553378" ], "products": [ "species_29370", "species_10553365" ], "modifiers": [ [ "species_10520688", "catalyst" ] ], "additional_components": [ "species_29438", "P22981", "WBGene00002335", "Q07292", "WBGene00003030", "Q07292", "WBGene00003030", "species_29438", "P22981", "WBGene00002335", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911" ] }, "reaction_10553383": { "compartment": "compartment_876", "id": "reaction_10553383", "reactome": "R-CEL-5624494", "name": "RAF1 binds p21 RAS:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10521086", "species_10511481" ], "products": [ "species_10553378" ], "modifiers": [], "additional_components": [ "WBGene00003030", "species_29438", "P22981", "WBGene00002335", "species_29438", "P22981", "WBGene00002335", "Q07292", "WBGene00003030" ] }, "reaction_10565907": { "compartment": "compartment_984", "id": "reaction_10565907", "reactome": "R-CEL-8862771", "name": "PLA2G2A binds bacterial phospholipids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10535794", "species_8931784" ], "products": [ "species_10565905" ], "modifiers": [], "additional_components": [ "O16654", "WBGene00044468", "Q17790", "WBGene00044468", "Q3V5J7", "WBGene00044468", "species_74016", "CHEBI:62643", "CHEBI:62643", "O16654", "WBGene00044468", "Q17790", "WBGene00044468", "Q3V5J7", "WBGene00044468", "species_74016" ] }, "reaction_10562932": { "compartment": "compartment_984", "id": "reaction_10562932", "reactome": "R-CEL-6801762", "name": "REG3A oligomerize to form a pore complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10562926" ], "products": [ "species_10562930" ], "modifiers": [ [ "species_166005", "inhibitor" ] ], "additional_components": [ "CHEBI:62643", "G4RY15", "WBGene00015631", "P34472", "WBGene00010228", "Q22591", "WBGene00020585", "CHEBI:62643", "G4RY15", "WBGene00015631", "P34472", "WBGene00010228", "Q22591", "WBGene00020585" ] }, "reaction_10562950": { "compartment": "compartment_984", "id": "reaction_10562950", "reactome": "R-CEL-6801776", "name": "REG3A binds bacterial phospholipids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10562924", "species_8931784" ], "products": [ "species_10562926" ], "modifiers": [], "additional_components": [ "G4RY15", "WBGene00015631", "P34472", "WBGene00010228", "Q22591", "WBGene00020585", "CHEBI:62643", "CHEBI:62643", "G4RY15", "WBGene00015631", "P34472", "WBGene00010228", "Q22591", "WBGene00020585" ] }, "reaction_10563816": { "compartment": "compartment_984", "id": "reaction_10563816", "reactome": "R-CEL-6810724", "name": "PI3 binds the bacterial surface", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6803081", "species_10563812" ], "products": [ "species_10563814" ], "modifiers": [], "additional_components": [ "O44131", "WBGene00015620", "O44131", "WBGene00015620", "species_166005" ] }, "reaction_10562954": { "compartment": "compartment_984", "id": "reaction_10562954", "reactome": "R-CEL-6801808", "name": "REG3A,REG3G binds bacterial peptidoglycan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10562924", "species_6789198" ], "products": [ "species_10562952" ], "modifiers": [], "additional_components": [ "G4RY15", "WBGene00015631", "P34472", "WBGene00010228", "Q22591", "WBGene00020585", "species_6789198", "G4RY15", "WBGene00015631", "P34472", "WBGene00010228", "Q22591", "WBGene00020585" ] }, "reaction_10563166": { "compartment": "compartment_984", "id": "reaction_10563166", "reactome": "R-CEL-6807585", "name": "BPI binds LPS on the bacterial surface", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6803081", "species_10510721" ], "products": [ "species_10563164" ], "modifiers": [], "additional_components": [ "WBGene00020563", "Q10011", "WBGene00020563", "species_166005" ] }, "reaction_10532731": { "compartment": "compartment_876", "id": "reaction_10532731", "reactome": "R-CEL-1296039", "name": "Activation of Ca2+ activated Potassium channels with small conductance", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10532728", "catalyst" ] ], "additional_components": [ "Q11122", "WBGene00015387", "V6CLK4", "WBGene00008570", "G5EFI1", "WBGene00007176", "O17697", "WBGene00008265" ] }, "reaction_10532702": { "compartment": "compartment_876", "id": "reaction_10532702", "reactome": "R-CEL-1296035", "name": "Activation of Ca2+ activated Potassium channels with Intermediate conductance", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10532699", "catalyst" ] ], "additional_components": [ "Q11122", "WBGene00015387", "V6CLK4", "WBGene00008570", "G5EFI1", "WBGene00007176", "O17697", "WBGene00008265" ] }, "reaction_10513650": { "compartment": "compartment_876", "id": "reaction_10513650", "reactome": "R-CEL-196017", "name": "Dynamin is recruited to the gap junction plaque", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10512940", "species_10512931" ], "products": [ "species_10512942" ], "modifiers": [], "additional_components": [ "A0A486WXX8", "WBGene00000894", "P35603", "WBGene00001082", "A0A486WXX8", "WBGene00000894", "P35603", "WBGene00001082" ] }, "reaction_10513652": { "compartment": "compartment_876", "id": "reaction_10513652", "reactome": "R-CEL-196026", "name": "Dab2 is recruited to the junctional plaques", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10512924", "species_10512929" ], "products": [ "species_10512931" ], "modifiers": [], "additional_components": [ "P35603", "WBGene00001082", "WBGene00000894", "A0A486WXX8", "WBGene00000894", "P35603", "WBGene00001082" ] }, "reaction_10524969": { "compartment": "compartment_876", "id": "reaction_10524969", "reactome": "R-CEL-445714", "name": "Aquaporin-3 passively transports water out of cell", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356" ], "products": [ "species_109276" ], "modifiers": [ [ "species_10524966", "catalyst" ] ], "additional_components": [ "Q7Z138", "WBGene00000176", "Q9XW36", "WBGene00000171", "Q17571", "WBGene00000170", "Q19949", "WBGene00000169", "Q21473", "WBGene00000175", "Q7YWQ1", "WBGene00013272" ] }, "reaction_10527170": { "compartment": "compartment_876", "id": "reaction_10527170", "reactome": "R-CEL-507869", "name": "Aquaporins passively transport glycerol into cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_192438" ], "products": [ "species_76116" ], "modifiers": [ [ "species_10527167", "catalyst" ] ], "additional_components": [ "Q7YWQ1", "WBGene00013272", "Q17571", "WBGene00000170", "Q7Z138", "WBGene00000176", "Q19949", "WBGene00000169", "Q9XW36", "WBGene00000171", "Q21473", "WBGene00000175" ] }, "reaction_10527172": { "compartment": "compartment_876", "id": "reaction_10527172", "reactome": "R-CEL-507870", "name": "Aquaporins passively transport water out of cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356" ], "products": [ "species_109276" ], "modifiers": [ [ "species_10527162", "catalyst" ] ], "additional_components": [ "Q7YWQ1", "WBGene00013272", "Q17571", "WBGene00000170", "Q7Z138", "WBGene00000176", "Q19949", "WBGene00000169", "Q9XW36", "WBGene00000171", "Q21473", "WBGene00000175", "G5EEK0", "WBGene00000172" ] }, "reaction_10527174": { "compartment": "compartment_876", "id": "reaction_10527174", "reactome": "R-CEL-507871", "name": "Aquaporins passively transport glycerol out of cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76116" ], "products": [ "species_192438" ], "modifiers": [ [ "species_10527167", "catalyst" ] ], "additional_components": [ "Q7YWQ1", "WBGene00013272", "Q17571", "WBGene00000170", "Q7Z138", "WBGene00000176", "Q19949", "WBGene00000169", "Q9XW36", "WBGene00000171", "Q21473", "WBGene00000175" ] }, "reaction_10527179": { "compartment": "compartment_876", "id": "reaction_10527179", "reactome": "R-CEL-507873", "name": "Aquaporins passively transport urea out of cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29514" ], "products": [ "species_432019" ], "modifiers": [ [ "species_10527176", "catalyst" ] ], "additional_components": [ "Q7YWQ1", "WBGene00013272", "Q17571", "WBGene00000170", "Q7Z138", "WBGene00000176", "Q19949", "WBGene00000169", "Q9XW36", "WBGene00000171", "Q21473", "WBGene00000175" ] }, "reaction_10527165": { "compartment": "compartment_876", "id": "reaction_10527165", "reactome": "R-CEL-507868", "name": "Aquaporins passively transport water into cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276" ], "products": [ "species_29356" ], "modifiers": [ [ "species_10527162", "catalyst" ] ], "additional_components": [ "Q7YWQ1", "WBGene00013272", "Q17571", "WBGene00000170", "Q7Z138", "WBGene00000176", "Q19949", "WBGene00000169", "Q9XW36", "WBGene00000171", "Q21473", "WBGene00000175", "G5EEK0", "WBGene00000172" ] }, "reaction_10527181": { "compartment": "compartment_876", "id": "reaction_10527181", "reactome": "R-CEL-507875", "name": "Aquaporins passively transport urea into cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_432019" ], "products": [ "species_29514" ], "modifiers": [ [ "species_10527176", "catalyst" ] ], "additional_components": [ "Q7YWQ1", "WBGene00013272", "Q17571", "WBGene00000170", "Q7Z138", "WBGene00000176", "Q19949", "WBGene00000169", "Q9XW36", "WBGene00000171", "Q21473", "WBGene00000175" ] }, "reaction_10551505": { "compartment": "compartment_70101", "id": "reaction_10551505", "reactome": "R-CEL-5340214", "name": "CYGB binds O2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10551501", "species_29368" ], "products": [ "species_10551503" ], "modifiers": [], "additional_components": [ "species_71185", "O17824", "WBGene00008996", "species_113534", "species_71185", "O17824", "WBGene00008996" ] }, "reaction_10570320": { "compartment": "compartment_70101", "id": "reaction_10570320", "reactome": "R-CEL-8981621", "name": "Neuroglobin:oxygen dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10570316" ], "products": [ "species_10570314", "species_29368" ], "modifiers": [], "additional_components": [ "species_113534", "species_71185", "Q7YZV1", "WBGene00016024", "species_71185", "Q7YZV1", "WBGene00016024" ] }, "reaction_10570501": { "compartment": "compartment_70101", "id": "reaction_10570501", "reactome": "R-CEL-8982617", "name": "CYGB:O2 dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10551503" ], "products": [ "species_10551501", "species_29368" ], "modifiers": [], "additional_components": [ "species_113534", "species_71185", "O17824", "WBGene00008996", "species_71185", "O17824", "WBGene00008996" ] }, "reaction_10570318": { "compartment": "compartment_70101", "id": "reaction_10570318", "reactome": "R-CEL-8981610", "name": "Neuroglobin binds oxygen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10570314", "species_29368" ], "products": [ "species_10570316" ], "modifiers": [], "additional_components": [ "species_71185", "Q7YZV1", "WBGene00016024", "species_113534", "species_71185", "Q7YZV1", "WBGene00016024" ] }, "reaction_10522434": { "compartment": "compartment_876", "id": "reaction_10522434", "reactome": "R-CEL-425483", "name": "SLC4A5,7,9 cotransport Na+ with 3HCO3-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111627", "species_83910" ], "products": [ "species_425425", "species_74113" ], "modifiers": [ [ "species_10522431", "catalyst" ] ], "additional_components": [ "B3WFV9", "WBGene00009920", "Q58QG8", "WBGene00019844" ] }, "reaction_10567850": { "compartment": "compartment_876", "id": "reaction_10567850", "reactome": "R-CEL-8878664", "name": "SLC4A4 cotransports Na+ with 3HCO3-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111627", "species_83910" ], "products": [ "species_425425", "species_74113" ], "modifiers": [ [ "species_10567847", "catalyst" ] ], "additional_components": [ "B3WFV9", "WBGene00009920", "Q58QG8", "WBGene00019844" ] }, "reaction_10522447": { "compartment": "compartment_876", "id": "reaction_10522447", "reactome": "R-CEL-425577", "name": "Na+-driven Cl-/HCO3- exchanger transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_425425", "species_352022", "species_74113" ], "products": [ "species_351626", "species_188972", "species_111627", "species_83910" ], "modifiers": [ [ "species_10522444", "catalyst" ] ], "additional_components": [ "B3WFV9", "WBGene00009920", "Q58QG8", "WBGene00019844" ] }, "reaction_10555169": { "compartment": "compartment_7660", "id": "reaction_10555169", "reactome": "R-CEL-5674387", "name": "Phosphorylated MAPKs translocate into the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10555165" ], "products": [ "species_10555167" ], "modifiers": [], "additional_components": [ "P39745", "WBGene00003401", "P39745", "WBGene00003401" ] }, "reaction_10555224": { "compartment": "compartment_70101", "id": "reaction_10555224", "reactome": "R-CEL-5675376", "name": "Cytosolic DUSPs dephosphorylate MAPKs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10555165", "species_29356" ], "products": [ "species_29372", "species_10555201" ], "modifiers": [ [ "species_10555221", "catalyst" ] ], "additional_components": [ "P39745", "WBGene00003401", "P39745", "WBGene00003401", "Q9XUJ0", "WBGene00012372" ] }, "reaction_10508594": { "compartment": "compartment_70101", "id": "reaction_10508594", "reactome": "R-CEL-109860", "name": "MAP2K1 phosphorylates MAPK3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10508567" ], "products": [ "species_29370", "species_10508585" ], "modifiers": [ [ "species_10508567", "catalyst" ], [ "species_10508590", "inhibitor" ] ], "additional_components": [ "Q10664", "WBGene00003186", "P39745", "WBGene00003401", "Q10664", "WBGene00003186", "P39745", "WBGene00003401", "Q10664", "WBGene00003186", "P39745", "WBGene00003401", "WBGene00003186" ] }, "reaction_10508569": { "compartment": "compartment_70101", "id": "reaction_10508569", "reactome": "R-CEL-109857", "name": "MAP2K1 binds MAPK3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508565", "species_10508560" ], "products": [ "species_10508567" ], "modifiers": [], "additional_components": [ "WBGene00003401", "WBGene00003186", "Q10664", "WBGene00003186", "P39745", "WBGene00003401" ] }, "reaction_10509182": { "compartment": "compartment_70101", "id": "reaction_10509182", "reactome": "R-CEL-112342", "name": "Inactivation of MAP2K1 by CDK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10509173" ], "products": [ "species_10508590", "species_29370" ], "modifiers": [ [ "species_10509179", "catalyst" ] ], "additional_components": [ "Q10664", "WBGene00003186", "WBGene00003186", "WBGene00000405" ] }, "reaction_10508606": { "compartment": "compartment_70101", "id": "reaction_10508606", "reactome": "R-CEL-109863", "name": "Dissociation of p-T,Y-MAPK3:MAP2K1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508585" ], "products": [ "species_10508583", "species_10508560" ], "modifiers": [], "additional_components": [ "Q10664", "WBGene00003186", "P39745", "WBGene00003401", "WBGene00003401", "WBGene00003186" ] }, "reaction_10570242": { "compartment": "compartment_7660", "id": "reaction_10570242", "reactome": "R-CEL-8979071", "name": "KDM6B binds iron", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546680", "species_111793" ], "products": [ "species_10546682" ], "modifiers": [], "additional_components": [ "Q19760", "WBGene00009089", "Q95QK3", "WBGene00017571", "species_113531", "Q19760", "WBGene00009089", "Q95QK3", "WBGene00017571" ] }, "reaction_10546756": { "compartment": "compartment_7660", "id": "reaction_10546756", "reactome": "R-CEL-3240295", "name": "PRC2-EZH2 trimethylates nucleosomes associated with CDKN2A promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10546668" ], "products": [ "species_77502", "species_10546666" ], "modifiers": [ [ "species_10517100", "catalyst" ] ], "additional_components": [ "P62784", "WBGene00001875", "K7ZUH9", "WBGene00001914", "Q10453", "WBGene00001945", "P62784", "WBGene00001875", "Q10453", "WBGene00001945", "K7ZUH9", "WBGene00001914", "Q9GYS1", "WBGene00003224", "O17514", "WBGene00003220", "P90916", "WBGene00003036", "P90917", "WBGene00004312" ] }, "reaction_10546703": { "compartment": "compartment_70101", "id": "reaction_10546703", "reactome": "R-CEL-3225851", "name": "ROS oxidize thioredoxin and activate MAP3K5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546692", "species_1250243" ], "products": [ "species_10506158", "species_10546690" ], "modifiers": [ [ "species_10546697", "catalyst" ] ], "additional_components": [ "Q09433", "WBGene00015062", "Q21029", "WBGene00003822", "WBGene00015062", "WBGene00003822", "WBGene00003247" ] }, "reaction_10546707": { "compartment": "compartment_70101", "id": "reaction_10546707", "reactome": "R-CEL-3228469", "name": "MAP3K5 phosphorylates MKK3 and MKK6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10525576" ], "products": [ "species_29370", "species_10525521" ], "modifiers": [ [ "species_10546690", "catalyst" ] ], "additional_components": [ "Q58AU7", "WBGene00018034", "Q58AU8", "WBGene00018035", "G5EDF7", "WBGene00004758", "Q58AU7", "WBGene00018034", "Q58AU8", "WBGene00018035", "G5EDF7", "WBGene00004758", "WBGene00003822" ] }, "reaction_10546685": { "compartment": "compartment_7660", "id": "reaction_10546685", "reactome": "R-CEL-3222593", "name": "KDM6B demethylates H3K27me3 on p16INK4A promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546666", "species_113671" ], "products": [ "species_10546668", "species_159939" ], "modifiers": [ [ "species_10546682", "catalyst" ] ], "additional_components": [ "P62784", "WBGene00001875", "Q10453", "WBGene00001945", "K7ZUH9", "WBGene00001914", "P62784", "WBGene00001875", "K7ZUH9", "WBGene00001914", "Q10453", "WBGene00001945", "species_113531", "Q19760", "WBGene00009089", "Q95QK3", "WBGene00017571" ] }, "reaction_10524560": { "compartment": "compartment_70101", "id": "reaction_10524560", "reactome": "R-CEL-443831", "name": "14-3-3-zeta binds Raf1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10521086", "species_10507059" ], "products": [ "species_10524558" ], "modifiers": [], "additional_components": [ "WBGene00003030", "Q20655", "WBGene00001502", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "P41932", "WBGene00003920", "Q07292", "WBGene00003030" ] }, "reaction_10524541": { "compartment": "compartment_70101", "id": "reaction_10524541", "reactome": "R-CEL-443439", "name": "c-Src binds Raf1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10521086", "species_10518252" ], "products": [ "species_10524539" ], "modifiers": [], "additional_components": [ "WBGene00003030", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q07292", "WBGene00003030" ] }, "reaction_10516411": { "compartment": "compartment_70101", "id": "reaction_10516411", "reactome": "R-CEL-209828", "name": "Tryptophan is hydroxylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29870", "species_29500", "species_29368" ], "products": [ "species_71112", "species_209911" ], "modifiers": [ [ "species_10516408", "catalyst" ] ], "additional_components": [ "G5EED8", "WBGene00006600", "species_113531" ] }, "reaction_10516429": { "compartment": "compartment_70101", "id": "reaction_10516429", "reactome": "R-CEL-209859", "name": "Decarboxylation of 5-hydroxytryptophan forms serotonin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_209911" ], "products": [ "species_113528", "species_209914" ], "modifiers": [ [ "species_10516426", "catalyst" ] ], "additional_components": [ "O45137", "WBGene00000239" ] }, "reaction_10533009": { "compartment": "compartment_7660", "id": "reaction_10533009", "reactome": "R-CEL-1362270", "name": "Phosphorylation of LIN52 component of MuvB by DYRK1A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10533001" ], "products": [ "species_113582", "species_10532993" ], "modifiers": [ [ "species_10533006", "catalyst" ] ], "additional_components": [ "P90916", "WBGene00003036", "Q95QD7", "WBGene00003037", "Q10120", "WBGene00003035", "P30630", "WBGene00002998", "Q23482", "WBGene00003022", "P90916", "WBGene00003036", "Q95QD7", "WBGene00003037", "P30630", "WBGene00002998", "Q23482", "WBGene00003022", "Q10120", "WBGene00003035", "WBGene00003149" ] }, "reaction_10533091": { "compartment": "compartment_7660", "id": "reaction_10533091", "reactome": "R-CEL-1363314", "name": "p107 (RBL1) binds CyclinE/A:CDK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10532106", "species_10533075" ], "products": [ "species_10533089" ], "modifiers": [], "additional_components": [ "WBGene00003020", "O61847", "WBGene00019362", "O61847", "WBGene00019362", "G5EDT1", "WBGene00003020" ] }, "reaction_10532997": { "compartment": "compartment_7660", "id": "reaction_10532997", "reactome": "R-CEL-1362261", "name": "p130 (RBL2) associates with MuvB to form DREAM complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10532993", "species_10532097" ], "products": [ "species_10532995" ], "modifiers": [], "additional_components": [ "P90916", "WBGene00003036", "Q95QD7", "WBGene00003037", "P30630", "WBGene00002998", "Q23482", "WBGene00003022", "Q10120", "WBGene00003035", "G5EDT1", "WBGene00003020", "G5EF11", "WBGene00001161", "Q22703", "WBGene00001061", "G5EDT1", "WBGene00003020", "G5EF11", "WBGene00001161", "Q22703", "WBGene00001061", "P90916", "WBGene00003036", "Q95QD7", "WBGene00003037", "P30630", "WBGene00002998", "Q23482", "WBGene00003022", "Q10120", "WBGene00003035" ] }, "reaction_10533079": { "compartment": "compartment_7660", "id": "reaction_10533079", "reactome": "R-CEL-1363303", "name": "p130 (RBL2) in complex with E2F4/5:DP1/2 binds to cyclin E/A:CDK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10533075", "species_10532097" ], "products": [ "species_10533077" ], "modifiers": [], "additional_components": [ "O61847", "WBGene00019362", "G5EDT1", "WBGene00003020", "G5EF11", "WBGene00001161", "Q22703", "WBGene00001061", "G5EDT1", "WBGene00003020", "G5EF11", "WBGene00001161", "Q22703", "WBGene00001061", "O61847", "WBGene00019362" ] }, "reaction_10532123": { "compartment": "compartment_7660", "id": "reaction_10532123", "reactome": "R-CEL-1227670", "name": "Recruitment of HDAC1 by p130 (RBL2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10532119", "species_10532097" ], "products": [ "species_10532121" ], "modifiers": [], "additional_components": [ "WBGene00001836", "G5EDT1", "WBGene00003020", "G5EF11", "WBGene00001161", "Q22703", "WBGene00001061", "G5EDT1", "WBGene00003020", "G5EF11", "WBGene00001161", "Q22703", "WBGene00001061", "G5ECH0", "WBGene00001836" ] }, "reaction_10533083": { "compartment": "compartment_7660", "id": "reaction_10533083", "reactome": "R-CEL-1363306", "name": "p130 (RBL2) binds Cyclin E/A:CDK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10533075", "species_10532081" ], "products": [ "species_10533081" ], "modifiers": [], "additional_components": [ "O61847", "WBGene00019362", "WBGene00003020", "G5EDT1", "WBGene00003020", "O61847", "WBGene00019362" ] }, "reaction_10532127": { "compartment": "compartment_7660", "id": "reaction_10532127", "reactome": "R-CEL-1227671", "name": "Recruitment of HDAC1 by p107 (RBL1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10532108", "species_10532119" ], "products": [ "species_10532125" ], "modifiers": [], "additional_components": [ "G5EF11", "WBGene00001161", "G5EDT1", "WBGene00003020", "Q22703", "WBGene00001061", "WBGene00001836", "G5ECH0", "WBGene00001836", "G5EF11", "WBGene00001161", "G5EDT1", "WBGene00003020", "Q22703", "WBGene00001061" ] }, "reaction_10533087": { "compartment": "compartment_7660", "id": "reaction_10533087", "reactome": "R-CEL-1363311", "name": "p107 (RBL1) in complex with E2F4:DP1/2 binds to cyclin E/A:CDK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10532108", "species_10533075" ], "products": [ "species_10533085" ], "modifiers": [], "additional_components": [ "G5EF11", "WBGene00001161", "G5EDT1", "WBGene00003020", "Q22703", "WBGene00001061", "O61847", "WBGene00019362", "O61847", "WBGene00019362", "G5EF11", "WBGene00001161", "G5EDT1", "WBGene00003020", "Q22703", "WBGene00001061" ] }, "reaction_10509407": { "compartment": "compartment_7660", "id": "reaction_10509407", "reactome": "R-CEL-113504", "name": "Detection of damage during initiation of DNA synthesis in S-phase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502577" ], "products": [ "species_10502123", "species_113656" ], "modifiers": [], "additional_components": [ "C7IVS4", "WBGene00012936", "P34471", "WBGene00004180", "O02334", "WBGene00004181", "Q21625", "WBGene00001002", "C7IVS4", "WBGene00012936", "P34471", "WBGene00004180", "O02334", "WBGene00004181", "Q21625", "WBGene00001002" ] }, "reaction_10502244": { "compartment": "compartment_7660", "id": "reaction_10502244", "reactome": "R-CEL-68919", "name": "Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502184", "species_10502240" ], "products": [ "species_10502242" ], "modifiers": [], "additional_components": [ "WBGene00012935", "O16297", "WBGene00003159", "Q95XQ8", "WBGene00003156", "Q9XXI9", "WBGene00003154", "Q21902", "WBGene00003157", "P34647", "WBGene00003158", "Q9XVR7", "WBGene00003155", "Q9XX16", "WBGene00012651", "Q23249", "WBGene00013857", "Q9XX17", "WBGene00012650", "Q21037", "WBGene00003882", "P91155", "WBGene00000382", "Q86S68", "WBGene00000413", "O16297", "WBGene00003159", "Q95XQ8", "WBGene00003156", "Q9XXI9", "WBGene00003154", "Q21902", "WBGene00003157", "P34647", "WBGene00003158", "Q9XVR7", "WBGene00003155", "Q9XX16", "WBGene00012651", "Q23249", "WBGene00013857", "Q9XX17", "WBGene00012650", "Q21037", "WBGene00003882", "P91155", "WBGene00000382", "Q86S68", "WBGene00000413", "Q9U2C2", "WBGene00012935" ] }, "reaction_10502246": { "compartment": "compartment_7660", "id": "reaction_10502246", "reactome": "R-CEL-68940", "name": "Cdt1 is displaced from the pre-replicative complex.", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502242" ], "products": [ "species_10502230", "species_10502099" ], "modifiers": [], "additional_components": [ "O16297", "WBGene00003159", "Q95XQ8", "WBGene00003156", "Q9XXI9", "WBGene00003154", "Q21902", "WBGene00003157", "P34647", "WBGene00003158", "Q9XVR7", "WBGene00003155", "Q9XX16", "WBGene00012651", "Q23249", "WBGene00013857", "Q9XX17", "WBGene00012650", "Q21037", "WBGene00003882", "P91155", "WBGene00000382", "Q86S68", "WBGene00000413", "Q9U2C2", "WBGene00012935", "Q9XX16", "WBGene00012651", "Q23249", "WBGene00013857", "Q9XX17", "WBGene00012650", "Q21037", "WBGene00003882", "P91155", "WBGene00000382", "O16297", "WBGene00003159", "Q95XQ8", "WBGene00003156", "Q9XXI9", "WBGene00003154", "Q21902", "WBGene00003157", "P34647", "WBGene00003158", "Q9XVR7", "WBGene00003155", "Q9U2C2", "WBGene00012935", "WBGene00000413" ] }, "reaction_10502584": { "compartment": "compartment_7660", "id": "reaction_10502584", "reactome": "R-CEL-68960", "name": "DNA polymerase epsilon binds at the origin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_68419", "species_10502145" ], "products": [ "species_10502147" ], "modifiers": [], "additional_components": [ "O62218", "WBGene00009368", "Q19196", "WBGene00017237", "Q22798", "WBGene00020823", "Q9NAC5", "WBGene00013150", "O62218", "WBGene00009368", "Q19196", "WBGene00017237", "Q22798", "WBGene00020823", "Q9NAC5", "WBGene00013150" ] }, "reaction_10502236": { "compartment": "compartment_7660", "id": "reaction_10502236", "reactome": "R-CEL-68917", "name": "Cdc45 associates with the pre-replicative complex at the origin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502232", "species_10502161" ], "products": [ "species_10502234" ], "modifiers": [], "additional_components": [ "O01493", "WBGene00016421", "Q9XX16", "WBGene00012651", "Q23249", "WBGene00013857", "Q9XX17", "WBGene00012650", "Q21037", "WBGene00003882", "P91155", "WBGene00000382", "O16297", "WBGene00003159", "Q95XQ8", "WBGene00003156", "Q9XXI9", "WBGene00003154", "Q21902", "WBGene00003157", "P34647", "WBGene00003158", "Q9XVR7", "WBGene00003155", "Q9U2C2", "WBGene00012935", "O61847", "WBGene00019362", "WBGene00009372", "Q7JMR0", "WBGene00009372", "O01493", "WBGene00016421", "Q9XX16", "WBGene00012651", "Q23249", "WBGene00013857", "Q9XX17", "WBGene00012650", "Q21037", "WBGene00003882", "P91155", "WBGene00000382", "O16297", "WBGene00003159", "Q95XQ8", "WBGene00003156", "Q9XXI9", "WBGene00003154", "Q21902", "WBGene00003157", "P34647", "WBGene00003158", "Q9XVR7", "WBGene00003155", "Q9U2C2", "WBGene00012935", "O61847", "WBGene00019362" ] }, "reaction_10502156": { "compartment": "compartment_7660", "id": "reaction_10502156", "reactome": "R-CEL-68914", "name": "DNA polymerase alpha:primase binds at the origin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502123", "species_10502147" ], "products": [ "species_10502149" ], "modifiers": [], "additional_components": [ "C7IVS4", "WBGene00012936", "P34471", "WBGene00004180", "O02334", "WBGene00004181", "Q21625", "WBGene00001002", "O62218", "WBGene00009368", "Q19196", "WBGene00017237", "Q22798", "WBGene00020823", "Q9NAC5", "WBGene00013150", "O62218", "WBGene00009368", "Q19196", "WBGene00017237", "Q22798", "WBGene00020823", "Q9NAC5", "WBGene00013150", "C7IVS4", "WBGene00012936", "P34471", "WBGene00004180", "O02334", "WBGene00004181", "Q21625", "WBGene00001002" ] }, "reaction_10546046": { "compartment": "compartment_7660", "id": "reaction_10546046", "reactome": "R-CEL-2990840", "name": "SENP1,2,5 proteolytically process SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546014" ], "products": [ "species_10528096" ], "modifiers": [ [ "species_10546043", "catalyst" ] ], "additional_components": [ "WBGene00004888", "WBGene00004888", "O44984", "WBGene00006740", "Q09353", "WBGene00006736", "Q23238", "WBGene00006737" ] }, "reaction_10570130": { "compartment": "compartment_7660", "id": "reaction_10570130", "reactome": "R-CEL-8956365", "name": "ZBED1 (DREF) SUMOylates CHD3 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546081", "species_10548000" ], "products": [ "species_10570122", "species_10546073" ], "modifiers": [ [ "species_10570127", "catalyst" ] ], "additional_components": [ "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "G5EBZ4", "WBGene00002637", "Q22516", "WBGene00000482", "P55853", "WBGene00004888", "G5EBZ4", "WBGene00002637", "Q22516", "WBGene00000482", "WBGene00006706", "WBGene00010704" ] }, "reaction_10549430": { "compartment": "compartment_7660", "id": "reaction_10549430", "reactome": "R-CEL-4616015", "name": "SUMOylation of HDAC2 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10547980", "species_10546081" ], "products": [ "species_10546073", "species_10549428" ], "modifiers": [ [ "species_10546081", "catalyst" ] ], "additional_components": [ "G5ECH0", "WBGene00001836", "Q09440", "WBGene00001835", "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "WBGene00006706", "Q09440", "WBGene00001835", "G5ECH0", "WBGene00001836", "P55853", "WBGene00004888", "Q95017", "WBGene00006706", "P55853", "WBGene00004888" ] }, "reaction_10549306": { "compartment": "compartment_7660", "id": "reaction_10549306", "reactome": "R-CEL-4570496", "name": "SUMOylation of Histone H4 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546081", "species_10506929" ], "products": [ "species_10546073", "species_10549304" ], "modifiers": [ [ "species_10546081", "catalyst" ] ], "additional_components": [ "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "WBGene00001875", "WBGene00006706", "P55853", "WBGene00004888", "P62784", "WBGene00001875", "Q95017", "WBGene00006706", "P55853", "WBGene00004888" ] }, "reaction_10549403": { "compartment": "compartment_7660", "id": "reaction_10549403", "reactome": "R-CEL-4615905", "name": "PIAS1 SUMOylates SATB1 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546081", "species_10518112" ], "products": [ "species_10546073", "species_10549401" ], "modifiers": [ [ "species_10528091", "catalyst" ] ], "additional_components": [ "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "WBGene00022861", "WBGene00006706", "P55853", "WBGene00004888", "Q86MI0", "WBGene00022861", "Q21970", "WBGene00011259", "Q94361", "WBGene00001574" ] }, "reaction_10549391": { "compartment": "compartment_7660", "id": "reaction_10549391", "reactome": "R-CEL-4615889", "name": "SUMOylation of HDAC1 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10532119", "species_10546081" ], "products": [ "species_10549389", "species_10546073" ], "modifiers": [ [ "species_10546081", "catalyst" ] ], "additional_components": [ "WBGene00001836", "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "P55853", "WBGene00004888", "G5ECH0", "WBGene00001836", "WBGene00006706", "Q95017", "WBGene00006706", "P55853", "WBGene00004888" ] }, "reaction_10508432": { "compartment": "compartment_70101", "id": "reaction_10508432", "reactome": "R-CEL-109539", "name": "Concentrative transport (import) of nucleosides plus sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179740", "species_74113" ], "products": [ "species_179741", "species_83910" ], "modifiers": [ [ "species_10508429", "catalyst" ] ], "additional_components": [ "species_83927", "CHEBI:16750", "CHEBI:16704", "species_83909", "species_83909", "species_83927", "CHEBI:16750", "CHEBI:16704", "WBGene00017867" ] }, "reaction_10508417": { "compartment": "compartment_70101", "id": "reaction_10508417", "reactome": "R-CEL-109530", "name": "Concentrative transport (import) of a nucleoside and a sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179738", "species_74113" ], "products": [ "species_179739", "species_83910" ], "modifiers": [ [ "species_10508414", "catalyst" ] ], "additional_components": [ "CHEBI:16704", "species_83928", "species_83909", "CHEBI:17562", "CHEBI:17256", "CHEBI:17256", "species_83909", "CHEBI:16704", "species_83928", "CHEBI:17562", "WBGene00017867" ] }, "reaction_10508420": { "compartment": "compartment_70101", "id": "reaction_10508420", "reactome": "R-CEL-109534", "name": "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179743" ], "products": [ "species_179737" ], "modifiers": [ [ "species_10508404", "catalyst" ] ], "additional_components": [ "species_83909", "species_83927", "CHEBI:16750", "CHEBI:16704", "species_83928", "CHEBI:17562", "species_83927", "CHEBI:16750", "CHEBI:16704", "species_83928", "species_83909", "CHEBI:17562", "WBGene00009499" ] }, "reaction_10527797": { "compartment": "compartment_70101", "id": "reaction_10527797", "reactome": "R-CEL-727749", "name": "SLC29A3 transports nucleosides from lysosomal lumen to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_727782" ], "products": [ "species_727746" ], "modifiers": [ [ "species_10527794", "catalyst" ] ], "additional_components": [ "species_83909", "species_83927", "CHEBI:16704", "CHEBI:16750", "CHEBI:17562", "species_83928", "species_83951", "species_83909", "species_83927", "CHEBI:16750", "CHEBI:16704", "species_83928", "CHEBI:17562", "species_83951", "WBGene00009499" ] }, "reaction_10508422": { "compartment": "compartment_70101", "id": "reaction_10508422", "reactome": "R-CEL-109536", "name": "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179737" ], "products": [ "species_179743" ], "modifiers": [ [ "species_10508404", "catalyst" ] ], "additional_components": [ "species_83927", "CHEBI:16750", "CHEBI:16704", "species_83928", "species_83909", "CHEBI:17562", "species_83909", "species_83927", "CHEBI:16750", "CHEBI:16704", "species_83928", "CHEBI:17562", "WBGene00009499" ] }, "reaction_10508407": { "compartment": "compartment_70101", "id": "reaction_10508407", "reactome": "R-CEL-109527", "name": "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179747" ], "products": [ "species_179742" ], "modifiers": [ [ "species_10508402", "catalyst" ] ], "additional_components": [ "species_83927", "CHEBI:16750", "species_83956", "CHEBI:16704", "species_83928", "species_113599", "species_83909", "species_83960", "species_83962", "species_83951", "CHEBI:17562", "CHEBI:16040", "species_83909", "CHEBI:16040", "species_83956", "species_83927", "CHEBI:16750", "CHEBI:16704", "species_83928", "species_83960", "species_83962", "CHEBI:17562", "species_83951", "species_113599", "WBGene00009499" ] }, "reaction_10508409": { "compartment": "compartment_70101", "id": "reaction_10508409", "reactome": "R-CEL-109529", "name": "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179742" ], "products": [ "species_179747" ], "modifiers": [ [ "species_10508402", "catalyst" ] ], "additional_components": [ "species_83909", "CHEBI:16040", "species_83956", "species_83927", "CHEBI:16750", "CHEBI:16704", "species_83928", "species_83960", "species_83962", "CHEBI:17562", "species_83951", "species_113599", "species_83927", "CHEBI:16750", "species_83956", "CHEBI:16704", "species_83928", "species_113599", "species_83909", "species_83960", "species_83962", "species_83951", "CHEBI:17562", "CHEBI:16040", "WBGene00009499" ] }, "reaction_10510169": { "compartment": "compartment_70616", "id": "reaction_10510169", "reactome": "R-CEL-163215", "name": "SLC25A5,6 dimers exchange ATP for ADP across the mitochondrial inner membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29370", "species_113593" ], "products": [ "species_113581", "species_113592" ], "modifiers": [ [ "species_10510166", "catalyst" ] ], "additional_components": [ "P91270", "WBGene00017770" ] }, "reaction_10508427": { "compartment": "compartment_70101", "id": "reaction_10508427", "reactome": "R-CEL-109538", "name": "Concentrative transport (import) of a nucleoside and two sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179737", "species_74113" ], "products": [ "species_179743", "species_83910" ], "modifiers": [ [ "species_10508424", "catalyst" ] ], "additional_components": [ "species_83927", "CHEBI:16750", "CHEBI:16704", "species_83928", "species_83909", "CHEBI:17562", "species_83909", "species_83927", "CHEBI:16750", "CHEBI:16704", "species_83928", "CHEBI:17562", "WBGene00017867" ] }, "reaction_10528229": { "compartment": "compartment_876", "id": "reaction_10528229", "reactome": "R-CEL-879585", "name": "SLC27A1,4,6 transport LCFAs from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_879559" ], "products": [ "species_879544" ], "modifiers": [ [ "species_10528226", "catalyst" ] ], "additional_components": [ "CHEBI:16196", "CHEBI:16196", "Q18916", "WBGene00017012", "Q19878", "WBGene00009218" ] }, "reaction_10527805": { "compartment": "compartment_20699", "id": "reaction_10527805", "reactome": "R-CEL-727759", "name": "SLC33A1 transports Ac-CoA from cytosol to Golgi lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76183" ], "products": [ "species_727753" ], "modifiers": [ [ "species_10527802", "catalyst" ] ], "additional_components": [ "WBGene00012033" ] }, "reaction_10528210": { "compartment": "compartment_876", "id": "reaction_10528210", "reactome": "R-CEL-879575", "name": "SLCOs, SLC16A2 transport T3,T4 from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_879603" ], "products": [ "species_879628" ], "modifiers": [ [ "species_10528207", "catalyst" ] ], "additional_components": [ "species_352326", "species_176667", "species_352326", "species_176667", "Q95ZT3", "WBGene00018568", "O62421", "WBGene00018568", "Q20538", "WBGene00018568", "Q93550", "WBGene00018568", "Q9XWC5", "WBGene00019346", "X5LPS1", "WBGene00019346", "X5LV99", "WBGene00019346" ] }, "reaction_10528168": { "compartment": "compartment_876", "id": "reaction_10528168", "reactome": "R-CEL-879562", "name": "SLCO2B1 has a narrow substrate specificity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_879553" ], "products": [ "species_879654" ], "modifiers": [ [ "species_10528165", "catalyst" ] ], "additional_components": [ "species_176496", "CHEBI:63836", "species_176501", "CHEBI:63836", "species_176501", "species_176496", "Q93550", "WBGene00018568", "Q95ZT3", "WBGene00018568", "O62421", "WBGene00018568", "Q20538", "WBGene00018568" ] }, "reaction_10572296": { "compartment": "compartment_876", "id": "reaction_10572296", "reactome": "R-CEL-9631987", "name": "SLCO1B1 transports T3,T4 from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_879603" ], "products": [ "species_879628" ], "modifiers": [ [ "species_10528178", "catalyst" ] ], "additional_components": [ "species_352326", "species_176667", "species_352326", "species_176667", "Q95ZT3", "WBGene00018568", "O62421", "WBGene00018568", "Q20538", "WBGene00018568", "Q93550", "WBGene00018568" ] }, "reaction_10528234": { "compartment": "compartment_876", "id": "reaction_10528234", "reactome": "R-CEL-879594", "name": "SLCO4C1 mediates the transport of digoxin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_879521" ], "products": [ "species_879517" ], "modifiers": [ [ "species_10528231", "catalyst" ] ], "additional_components": [ "WBGene00019346" ] }, "reaction_10528155": { "compartment": "compartment_876", "id": "reaction_10528155", "reactome": "R-CEL-879528", "name": "SLCO2A1 transports PGT substrates from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_879566" ], "products": [ "species_879614" ], "modifiers": [ [ "species_10528152", "catalyst" ] ], "additional_components": [ "species_879535", "CHEBI:15544", "species_879629", "species_265287", "species_879629", "CHEBI:15544", "species_879535", "species_265287", "Q93550", "WBGene00018568", "Q95ZT3", "WBGene00018568", "O62421", "WBGene00018568", "Q20538", "WBGene00018568" ] }, "reaction_10543903": { "compartment": "compartment_876", "id": "reaction_10543903", "reactome": "R-CEL-2317314", "name": "AKT binds PDPK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10513830", "species_10508530" ], "products": [ "species_10513832" ], "modifiers": [], "additional_components": [ "Q17941", "WBGene00000102", "Q9XTG7", "WBGene00000103", "G4S4W1", "WBGene00016980", "species_179838", "Q9UA62", "WBGene00021022", "species_179838", "Q9UA62", "WBGene00021022", "species_179838", "Q17941", "WBGene00000102", "Q9XTG7", "WBGene00000103", "G4S4W1", "WBGene00016980" ] }, "reaction_10543806": { "compartment": "compartment_70101", "id": "reaction_10543806", "reactome": "R-CEL-2316429", "name": "PIP3 recruits PDPK1 to the membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179838", "species_10515193" ], "products": [ "species_10508530" ], "modifiers": [], "additional_components": [ "WBGene00021022", "Q9UA62", "WBGene00021022", "species_179838" ] }, "reaction_10543581": { "compartment": "compartment_70101", "id": "reaction_10543581", "reactome": "R-CEL-2219524", "name": "PDPK1 binds PIP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10515193", "species_179856" ], "products": [ "species_10543579" ], "modifiers": [], "additional_components": [ "WBGene00021022", "Q9UA62", "WBGene00021022", "species_179856" ] }, "reaction_10513851": { "compartment": "compartment_70101", "id": "reaction_10513851", "reactome": "R-CEL-198270", "name": "PDPK1 phosphorylates AKT at T308", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10513832" ], "products": [ "species_29370", "species_10513848", "species_10508530" ], "modifiers": [ [ "species_10513832", "catalyst" ] ], "additional_components": [ "Q9UA62", "WBGene00021022", "species_179838", "Q17941", "WBGene00000102", "Q9XTG7", "WBGene00000103", "G4S4W1", "WBGene00016980", "Q9XTG7", "WBGene00000103", "G4S4W1", "WBGene00016980", "Q17941", "WBGene00000102", "Q9UA62", "WBGene00021022", "species_179838", "Q9UA62", "WBGene00021022", "species_179838", "Q17941", "WBGene00000102", "Q9XTG7", "WBGene00000103", "G4S4W1", "WBGene00016980" ] }, "reaction_10513960": { "compartment": "compartment_70101", "id": "reaction_10513960", "reactome": "R-CEL-198640", "name": "TORC2 (mTOR) phosphorylates AKT at S473", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10513939" ], "products": [ "species_29370", "species_10513830" ], "modifiers": [ [ "species_10513953", "catalyst" ], [ "species_10513958", "inhibitor" ] ], "additional_components": [ "Q17941", "WBGene00000102", "Q9XTG7", "WBGene00000103", "G4S4W1", "WBGene00016980", "species_179838", "Q17941", "WBGene00000102", "Q9XTG7", "WBGene00000103", "G4S4W1", "WBGene00016980", "species_179838", "P91040", "WBGene00015697", "Q95Q95", "WBGene00002583", "G5EFN2", "WBGene00009245", "Q9NA80", "WBGene00013261", "Q17941", "WBGene00000102", "Q9XTG7", "WBGene00000103", "G4S4W1", "WBGene00016980", "species_179838", "G5EED4", "WBGene00010700" ] }, "reaction_10509479": { "compartment": "compartment_70101", "id": "reaction_10509479", "reactome": "R-CEL-114542", "name": "RAC1,RAC2,RHOG activate PI3K", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10506892", "species_10509473" ], "products": [ "species_10509477" ], "modifiers": [], "additional_components": [ "G5EDP9", "WBGene00000001", "Q94125", "WBGene00000090", "species_29438", "Q03206", "ced-10", "Q94124", "WBGene00004287", "Q9BL44", "WBGene00022177", "species_29438", "Q03206", "ced-10", "Q94124", "WBGene00004287", "Q9BL44", "WBGene00022177", "G5EDP9", "WBGene00000001", "Q94125", "WBGene00000090" ] }, "reaction_10514322": { "compartment": "compartment_876", "id": "reaction_10514322", "reactome": "R-CEL-199443", "name": "THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10513956", "species_10513939" ], "products": [ "species_10513958" ], "modifiers": [], "additional_components": [ "WBGene00010700", "Q17941", "WBGene00000102", "Q9XTG7", "WBGene00000103", "G4S4W1", "WBGene00016980", "species_179838", "Q17941", "WBGene00000102", "Q9XTG7", "WBGene00000103", "G4S4W1", "WBGene00016980", "species_179838", "G5EED4", "WBGene00010700" ] }, "reaction_10514330": { "compartment": "compartment_70101", "id": "reaction_10514330", "reactome": "R-CEL-199456", "name": "PTEN dephosphorylates PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_179838" ], "products": [ "species_29372", "species_179856" ], "modifiers": [ [ "species_10514327", "catalyst" ] ], "additional_components": [ "WBGene00000913" ] }, "reaction_10543905": { "compartment": "compartment_70101", "id": "reaction_10543905", "reactome": "R-CEL-2317332", "name": "PIP3 recruits AKT to the membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179838", "species_10520802" ], "products": [ "species_10513939" ], "modifiers": [], "additional_components": [ "G4S4W1", "WBGene00016980", "Q17941", "WBGene00000102", "Q9XTG7", "WBGene00000103", "Q17941", "WBGene00000102", "Q9XTG7", "WBGene00000103", "G4S4W1", "WBGene00016980", "species_179838" ] }, "reaction_10565073": { "compartment": "compartment_70101", "id": "reaction_10565073", "reactome": "R-CEL-8850992", "name": "Proteasome degrades polyubiquitinated PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10565071" ], "products": [ "species_10502375" ], "modifiers": [ [ "species_10502572", "catalyst" ] ], "additional_components": [ "G5EE01", "WBGene00000913", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "P91477", "WBGene00003950", "Q95PZ7", "WBGene00013435", "Q18115", "WBGene00004459", "O62102", "WBGene00003948", "O17071", "WBGene00004504", "Q10920", "WBGene00016623", "P34286", "WBGene00003952", "Q9XTT9", "WBGene00004506", "Q23449", "WBGene00004468", "Q95005", "WBGene00003925", "P46502", "WBGene00004503", "O61792", "WBGene00004464", "O17586", "WBGene00003922", "O76371", "WBGene00004505", "Q20585", "WBGene00004463", "Q95008", "WBGene00003926", "Q18787", "WBGene00004501", "Q20058", "WBGene00009445", "Q9N599", "WBGene00003924", "O16368", "WBGene00004502", "O61742", "WBGene00004466", "Q09583", "WBGene00003928", "Q966I8", "WBGene00003947", "Q04908", "WBGene00004460", "Q9XUV0", "WBGene00003951", "Q27488", "WBGene00003923", "Q9GZH5", "WBGene00004458", "O44156", "WBGene00003927", "Q22253", "WBGene00004465", "O76577", "WBGene00004467", "P90868", "WBGene00003953", "Q19324", "WBGene00004461", "Q17971", "WBGene00007588", "Q23237", "WBGene00003949", "Q20938", "WBGene00004462" ] }, "reaction_10564578": { "compartment": "compartment_70101", "id": "reaction_10564578", "reactome": "R-CEL-8847968", "name": "PTEN binds FRK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10564574", "species_10514327" ], "products": [ "species_10564576" ], "modifiers": [], "additional_components": [ "WBGene00005078", "WBGene00000913", "G5EE01", "WBGene00000913", "O45539", "WBGene00005078" ] }, "reaction_10565061": { "compartment": "compartment_70101", "id": "reaction_10565061", "reactome": "R-CEL-8850945", "name": "Casein kinase II phosphorylates PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10514327" ], "products": [ "species_29370", "species_10565059" ], "modifiers": [ [ "species_10515097", "catalyst" ] ], "additional_components": [ "WBGene00000913", "WBGene00000913", "P18334", "WBGene00002191", "P28548", "WBGene00002196" ] }, "reaction_10563159": { "compartment": "compartment_70101", "id": "reaction_10563159", "reactome": "R-CEL-6807134", "name": "NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502375", "species_10514327" ], "products": [ "species_10563152" ], "modifiers": [ [ "species_10563156", "catalyst" ] ], "additional_components": [ "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "WBGene00000913", "WBGene00000913", "G5ECY6", "WBGene00000500", "Q9N2Z7", "WBGene00007009", "A0A061ACQ8", "WBGene00022358" ] }, "reaction_10565079": { "compartment": "compartment_70101", "id": "reaction_10565079", "reactome": "R-CEL-8850997", "name": "TRIM27 binds PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10514327", "species_10565075" ], "products": [ "species_10565077" ], "modifiers": [], "additional_components": [ "WBGene00000913", "WBGene00021640", "Q9N3T6", "WBGene00021640", "G5EE01", "WBGene00000913" ] }, "reaction_10568856": { "compartment": "compartment_70101", "id": "reaction_10568856", "reactome": "R-CEL-8948775", "name": "MKRN1 polyubiquitinates PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502375", "species_10514327" ], "products": [ "species_10563162" ], "modifiers": [ [ "species_10568851", "catalyst" ] ], "additional_components": [ "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "WBGene00000913", "WBGene00000913", "WBGene00002278" ] }, "reaction_10564584": { "compartment": "compartment_70101", "id": "reaction_10564584", "reactome": "R-CEL-8847977", "name": "FRK phosphorylates PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10564576" ], "products": [ "species_10564574", "species_29370", "species_10564581" ], "modifiers": [ [ "species_10564576", "catalyst" ] ], "additional_components": [ "G5EE01", "WBGene00000913", "O45539", "WBGene00005078", "WBGene00005078", "WBGene00000913", "G5EE01", "WBGene00000913", "O45539", "WBGene00005078" ] }, "reaction_10568861": { "compartment": "compartment_70101", "id": "reaction_10568861", "reactome": "R-CEL-8948832", "name": "RNF146 polyubiquitinates PARylated PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10568858", "species_10502375" ], "products": [ "species_10565069" ], "modifiers": [ [ "species_10547738", "catalyst" ] ], "additional_components": [ "WBGene00000913", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "WBGene00000913", "WBGene00013674" ] }, "reaction_10565085": { "compartment": "compartment_70101", "id": "reaction_10565085", "reactome": "R-CEL-8851011", "name": "TRIM27 polyubiquitinates PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502375", "species_10565077" ], "products": [ "species_10565082", "species_10565075" ], "modifiers": [ [ "species_10565077", "catalyst" ] ], "additional_components": [ "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "Q9N3T6", "WBGene00021640", "G5EE01", "WBGene00000913", "WBGene00000913", "WBGene00021640", "Q9N3T6", "WBGene00021640", "G5EE01", "WBGene00000913" ] }, "reaction_10568800": { "compartment": "compartment_13231", "id": "reaction_10568800", "reactome": "R-CEL-8944457", "name": "MAF1 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10568791" ], "products": [ "species_10568789" ], "modifiers": [ [ "species_10510588", "inhibitor" ] ], "additional_components": [ "WBGene00016622", "WBGene00016622", "Q19425", "WBGene00008774", "species_29420", "G5EGB3", "WBGene00012497", "Q22743", "WBGene00006414", "species_29438", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "P91040", "WBGene00015697", "Q95Q95", "WBGene00002583", "Q68TI8", "WBGene00000911", "P34443", "WBGene00010038" ] }, "reaction_10568738": { "compartment": "compartment_7660", "id": "reaction_10568738", "reactome": "R-CEL-8943817", "name": "MECOM (EVI1) recruits polycomb repressor complexes (PRCs) to the PTEN gene promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10568732", "species_10568730" ], "products": [ "species_10568736" ], "modifiers": [], "additional_components": [ "Q22024", "WBGene00001207", "Q22024", "WBGene00001207" ] }, "reaction_10568726": { "compartment": "compartment_7660", "id": "reaction_10568726", "reactome": "R-CEL-8943780", "name": "SALL4 recruits NuRD to PTEN gene", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10548019", "species_10568720" ], "products": [ "species_10568724" ], "modifiers": [], "additional_components": [ "P90916", "WBGene00003036", "G5EBZ4", "WBGene00002637", "Q22516", "WBGene00000482", "G5ECR1", "WBGene00023409", "O61907", "WBGene00003025", "P90917", "WBGene00004312", "G5ECH0", "WBGene00001836", "Q09440", "WBGene00001835", "G5EFF4", "WBGene00004773", "P90916", "WBGene00003036", "G5EBZ4", "WBGene00002637", "Q22516", "WBGene00000482", "G5ECR1", "WBGene00023409", "O61907", "WBGene00003025", "P90917", "WBGene00004312", "G5ECH0", "WBGene00001836", "Q09440", "WBGene00001835", "G5EFF4", "WBGene00004773" ] }, "reaction_10568798": { "compartment": "compartment_70101", "id": "reaction_10568798", "reactome": "R-CEL-8944454", "name": "mTORC1 phosphorylates MAF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10568791" ], "products": [ "species_10568796", "species_29370" ], "modifiers": [ [ "species_10510588", "catalyst" ] ], "additional_components": [ "WBGene00016622", "WBGene00016622", "Q19425", "WBGene00008774", "species_29420", "G5EGB3", "WBGene00012497", "Q22743", "WBGene00006414", "species_29438", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "P91040", "WBGene00015697", "Q95Q95", "WBGene00002583", "Q68TI8", "WBGene00000911", "P34443", "WBGene00010038" ] }, "reaction_10563141": { "compartment": "compartment_70101", "id": "reaction_10563141", "reactome": "R-CEL-6807105", "name": "Monoubiquitinated PTEN translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10563135" ], "products": [ "species_10563139" ], "modifiers": [], "additional_components": [ "WBGene00000913", "WBGene00000913" ] }, "reaction_10563146": { "compartment": "compartment_7660", "id": "reaction_10563146", "reactome": "R-CEL-6807118", "name": "USP7 deubiquitinates monoubiquitinated PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10563139" ], "products": [ "species_10502318", "species_10563143" ], "modifiers": [ [ "species_10556169", "catalyst" ], [ "species_10546215", "inhibitor" ] ], "additional_components": [ "WBGene00000913", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "WBGene00000913", "WBGene00010406", "WBGene00006523" ] }, "reaction_10563149": { "compartment": "compartment_7660", "id": "reaction_10563149", "reactome": "R-CEL-6807126", "name": "Deubiquitinated PTEN translocates to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10563143" ], "products": [ "species_10514327" ], "modifiers": [], "additional_components": [ "WBGene00000913", "WBGene00000913" ] }, "reaction_10503794": { "compartment": "compartment_70101", "id": "reaction_10503794", "reactome": "R-CEL-71164", "name": "homogentisate + O2 => maleylacetoacetate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_30337" ], "products": [ "species_31135" ], "modifiers": [ [ "species_10503791", "catalyst" ] ], "additional_components": [ "species_113531", "Q9Y041", "WBGene00001843" ] }, "reaction_10503765": { "compartment": "compartment_70101", "id": "reaction_10503765", "reactome": "R-CEL-71155", "name": "tyrosine + alpha-ketoglutarate <=> p-hydroxyphenylpyruvate + glutamate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29406", "species_29506" ], "products": [ "species_29404", "species_31365" ], "modifiers": [ [ "species_10503762", "catalyst" ] ], "additional_components": [ "Q93703", "WBGene00009628" ] }, "reaction_10503814": { "compartment": "compartment_70101", "id": "reaction_10503814", "reactome": "R-CEL-71181", "name": "fumarylacetoacetate => fumarate + acetoacetate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_31175" ], "products": [ "species_29666", "species_29586" ], "modifiers": [ [ "species_10503811", "catalyst" ] ], "additional_components": [ "Q94272", "WBGene00019620" ] }, "reaction_10503784": { "compartment": "compartment_70101", "id": "reaction_10503784", "reactome": "R-CEL-71163", "name": "p-hydroxyphenylpyruvate + O2 => homogentisate + CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_31365" ], "products": [ "species_113528", "species_30337" ], "modifiers": [ [ "species_10503781", "catalyst" ] ], "additional_components": [ "Q18347", "WBGene00016294", "Q22633", "WBGene00001993", "species_198836", "species_113531" ] }, "reaction_10503804": { "compartment": "compartment_70101", "id": "reaction_10503804", "reactome": "R-CEL-71173", "name": "maleylacetoacetate => fumarylacetoacetate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_31135" ], "products": [ "species_31175" ], "modifiers": [ [ "species_10503801", "catalyst" ] ], "additional_components": [ "Q18938", "WBGene00001790", "species_1655887" ] }, "reaction_10534912": { "compartment": "compartment_12045", "id": "reaction_10534912", "reactome": "R-CEL-1482867", "name": "DLCL is acylated to MLCL by LCLAT1 (ER)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524080", "species_1500578" ], "products": [ "species_76194", "species_1524069" ], "modifiers": [ [ "species_10507525", "catalyst" ] ], "additional_components": [ "WBGene00020264" ] }, "reaction_10534881": { "compartment": "compartment_70616", "id": "reaction_10534881", "reactome": "R-CEL-1482781", "name": "MLCL and PC are converted to CL and 1-acyl LPC by TAZ (IM) (Reversible)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524075", "species_1498773" ], "products": [ "species_1524072", "species_1524079" ], "modifiers": [ [ "species_10534878", "catalyst" ] ], "additional_components": [ "WBGene00006491" ] }, "reaction_10534899": { "compartment": "compartment_70616", "id": "reaction_10534899", "reactome": "R-CEL-1482850", "name": "MLCL and PE are converted to CL and 1-acyl LPE by TAZ (IM) (Reversible)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524083", "species_1498773" ], "products": [ "species_1524072", "species_1524089" ], "modifiers": [ [ "species_10534878", "catalyst" ] ], "additional_components": [ "WBGene00006491" ] }, "reaction_10534868": { "compartment": "compartment_70616", "id": "reaction_10534868", "reactome": "R-CEL-1482775", "name": "MLCL is acylated to CL by HADH (IM)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1498773", "species_1524038" ], "products": [ "species_1524072", "species_29374" ], "modifiers": [ [ "species_10534865", "catalyst" ] ], "additional_components": [ "P34255", "WBGene00015125", "Q9GYT0", "WBGene00020347" ] }, "reaction_10534910": { "compartment": "compartment_12045", "id": "reaction_10534910", "reactome": "R-CEL-1482861", "name": "MLCL is acylated to CL by LCLAT1 (ER)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500578", "species_1524069" ], "products": [ "species_1524081", "species_76194" ], "modifiers": [ [ "species_10507525", "catalyst" ] ], "additional_components": [ "WBGene00020264" ] }, "reaction_10520252": { "compartment": "compartment_876", "id": "reaction_10520252", "reactome": "R-CEL-381750", "name": "Olfactory Receptor - G Protein olfactory trimer complex formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10520171", "species_10520178" ], "products": [ "species_10520198" ], "modifiers": [ [ "species_10520250", "catalyst" ] ], "additional_components": [ "Q7KPV0", "WBGene00001745", "V6CLB7", "WBGene00020997", "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682", "WBGene00001052", "Q86ME6", "WBGene00001052", "Q7KPV0", "WBGene00001745", "V6CLB7", "WBGene00020997", "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682", "Q10010", "WBGene00020562", "P34296", "WBGene00020562" ] }, "reaction_10520173": { "compartment": "compartment_876", "id": "reaction_10520173", "reactome": "R-CEL-381749", "name": "G Protein trimer formation (olfactory)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509147", "species_10510821", "species_10511281" ], "products": [ "species_10520171" ], "modifiers": [], "additional_components": [ "WBGene00001682", "WBGene00001679", "Q7KPV0", "WBGene00001745", "V6CLB7", "WBGene00020997", "Q7KPV0", "WBGene00001745", "V6CLB7", "WBGene00020997", "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682" ] }, "reaction_10568896": { "compartment": "compartment_70616", "id": "reaction_10568896", "reactome": "R-CEL-8949580", "name": "F1Fo ATP synthase dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10510406" ], "products": [ "species_10568894" ], "modifiers": [], "additional_components": [ "O16314", "WBGene00015460", "Q18803", "WBGene00000210", "Q17763", "WBGene00007385", "Q19126", "WBGene00000207", "Q9BKS0", "WBGene00022336", "Q21732", "WBGene00011015", "O16517", "WBGene00020275", "Q22021", "WBGene00011273", "Q09544", "WBGene00019061", "Q9XXK1", "WBGene00010419", "O16298", "WBGene00017982", "P46561", "WBGene00000229", "Q95XJ0", "WBGene00022089", "Q7JNG1", "WBGene00000230", "O16314", "WBGene00015460", "Q18803", "WBGene00000210", "Q17763", "WBGene00007385", "Q19126", "WBGene00000207", "Q9BKS0", "WBGene00022336", "Q21732", "WBGene00011015", "O16517", "WBGene00020275", "Q22021", "WBGene00011273", "Q09544", "WBGene00019061", "Q9XXK1", "WBGene00010419", "O16298", "WBGene00017982", "P46561", "WBGene00000229", "Q95XJ0", "WBGene00022089", "Q7JNG1", "WBGene00000230" ] }, "reaction_10549204": { "compartment": "compartment_12045", "id": "reaction_10549204", "reactome": "R-CEL-4419979", "name": "SRD5A3 reduces pPNOL to DCHOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_4419981", "species_29364" ], "products": [ "species_29366", "species_449221" ], "modifiers": [ [ "species_10549201", "catalyst" ] ], "additional_components": [ "WBGene00007102" ] }, "reaction_10525099": { "compartment": "compartment_12045", "id": "reaction_10525099", "reactome": "R-CEL-446195", "name": "DOLK phosphorylates DCHOL to DOLP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_110614", "species_449221" ], "products": [ "species_110094", "species_449299" ], "modifiers": [ [ "species_10525096", "catalyst" ] ], "additional_components": [ "WBGene00044233" ] }, "reaction_10549196": { "compartment": "compartment_12045", "id": "reaction_10549196", "reactome": "R-CEL-4419978", "name": "DHDDS:NUS1 elongates E,E-FPP with (n)IPPP to form pPPP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191362", "species_4419987" ], "products": [ "species_4419982" ], "modifiers": [ [ "species_10549193", "catalyst" ] ], "additional_components": [ "Q5FC21", "WBGene00044025", "Q20118", "WBGene00009505" ] }, "reaction_10523190": { "compartment": "compartment_17938", "id": "reaction_10523190", "reactome": "R-CEL-428585", "name": "SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428040", "species_428639" ], "products": [ "species_428633", "species_70106" ], "modifiers": [ [ "species_10523187", "catalyst" ] ], "additional_components": [ "WBGene00008000" ] }, "reaction_10525409": { "compartment": "compartment_70101", "id": "reaction_10525409", "reactome": "R-CEL-449715", "name": "GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29512", "species_29472" ], "products": [ "species_29404", "species_449701" ], "modifiers": [ [ "species_10525406", "catalyst" ] ], "additional_components": [ "Q19130", "WBGene00008546", "Q19699", "WBGene00009035" ] }, "reaction_10525137": { "compartment": "compartment_70101", "id": "reaction_10525137", "reactome": "R-CEL-446204", "name": "GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29494", "species_532204" ], "products": [ "species_111294", "species_162756" ], "modifiers": [ [ "species_10525134", "catalyst" ] ], "additional_components": [ "Q18493", "WBGene00007965" ] }, "reaction_10563013": { "compartment": "compartment_70101", "id": "reaction_10563013", "reactome": "R-CEL-6803771", "name": "NAGK dimer phosphorylates GlcNAc, GlcNGc to GlcNAc-6-P, GlcNGc-6-P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6803785", "species_113592" ], "products": [ "species_6803738", "species_70106", "species_29370" ], "modifiers": [ [ "species_10563010", "catalyst" ] ], "additional_components": [ "CHEBI:27459", "species_1678743", "species_449703", "species_6803743", "Q23196", "WBGene00021056" ] }, "reaction_10525061": { "compartment": "compartment_70101", "id": "reaction_10525061", "reactome": "R-CEL-446185", "name": "Isomerization of GlcNAc6P to GlcNAc1P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449703" ], "products": [ "species_532204" ], "modifiers": [ [ "species_10525058", "catalyst" ] ], "additional_components": [ "WBGene00009006" ] }, "reaction_10525419": { "compartment": "compartment_70101", "id": "reaction_10525419", "reactome": "R-CEL-449734", "name": "Acetylation of glucosamine 6-phosphate to GlcNAc6P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76183", "species_449701" ], "products": [ "species_76194", "species_449703" ], "modifiers": [ [ "species_10525416", "catalyst" ] ], "additional_components": [ "Q17427", "WBGene00001646" ] }, "reaction_10563021": { "compartment": "compartment_70101", "id": "reaction_10563021", "reactome": "R-CEL-6803789", "name": "AMDHD2 hydrolyses GlcNGc-6-P to GlcN6P and CCA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_6803743" ], "products": [ "species_193473", "species_449701" ], "modifiers": [ [ "species_10563018", "catalyst" ] ], "additional_components": [ "WBGene00010308" ] }, "reaction_10527233": { "compartment": "compartment_70101", "id": "reaction_10527233", "reactome": "R-CEL-532549", "name": "MPI isomerises Fru6P to Man6P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29512" ], "products": [ "species_532562" ], "modifiers": [ [ "species_10527230", "catalyst" ] ], "additional_components": [ "WBGene00014013" ] }, "reaction_10525119": { "compartment": "compartment_70101", "id": "reaction_10525119", "reactome": "R-CEL-446201", "name": "PMM1,2 isomerise Man6P to Man1P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_532562" ], "products": [ "species_532531" ], "modifiers": [ [ "species_10525116", "catalyst" ] ], "additional_components": [ "Q9XUE6", "WBGene00009925" ] }, "reaction_10558241": { "compartment": "compartment_70101", "id": "reaction_10558241", "reactome": "R-CEL-6787540", "name": "FUK phosphorylates beta-Fuc to Fuc1P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_6787678" ], "products": [ "species_29370", "species_6787542" ], "modifiers": [ [ "species_10558238", "catalyst" ] ], "additional_components": [ "WBGene00007745" ] }, "reaction_10558259": { "compartment": "compartment_70101", "id": "reaction_10558259", "reactome": "R-CEL-6787632", "name": "GMDS dehydrates GDP-Man to GDP-DHDMan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_162860" ], "products": [ "species_29356", "species_6787618" ], "modifiers": [ [ "species_10558256", "catalyst" ] ], "additional_components": [ "WBGene00000266" ] }, "reaction_10558262": { "compartment": "compartment_70101", "id": "reaction_10558262", "reactome": "R-CEL-6787642", "name": "TSTA3 dimer reduces GDP-KDGal to GDP-Fuc", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_6787646", "species_29364" ], "products": [ "species_742368", "species_29366" ], "modifiers": [ [ "species_10558248", "catalyst" ] ], "additional_components": [ "G5EER4", "WBGene00019813" ] }, "reaction_10558233": { "compartment": "compartment_70101", "id": "reaction_10558233", "reactome": "R-CEL-6787533", "name": "FPGT transfers guanylyl group from GTP to Fuc1P to form GDP-Fuc", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_6787542" ], "products": [ "species_111294", "species_742368" ], "modifiers": [ [ "species_10558230", "catalyst" ] ], "additional_components": [ "WBGene00044903" ] }, "reaction_10558251": { "compartment": "compartment_70101", "id": "reaction_10558251", "reactome": "R-CEL-6787623", "name": "TSTA3 dimer epimerises GDP-DHDMan to GDP-KDGal", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6787618" ], "products": [ "species_6787646" ], "modifiers": [ [ "species_10558248", "catalyst" ] ], "additional_components": [ "G5EER4", "WBGene00019813" ] }, "reaction_10555857": { "compartment": "compartment_7660", "id": "reaction_10555857", "reactome": "R-CEL-5685230", "name": "CHEK1 phosphorylates RAD51", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10555852" ], "products": [ "species_113582", "species_10555855" ], "modifiers": [ [ "species_10502788", "catalyst" ] ], "additional_components": [ "WBGene00004297", "WBGene00004297", "WBGene00000498" ] }, "reaction_10503589": { "compartment": "compartment_5460", "id": "reaction_10503589", "reactome": "R-CEL-70979", "name": "(S)-Malate + NAD+ <=> Oxaloacetate + NADH + H+", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113544", "species_113526" ], "products": [ "species_113529", "species_29362", "species_113587" ], "modifiers": [ [ "species_10503586", "catalyst" ] ], "additional_components": [ "O02640", "WBGene00003162" ] }, "reaction_10504295": { "compartment": "compartment_5460", "id": "reaction_10504295", "reactome": "R-CEL-71775", "name": "GDP + Orthophosphate + Succinyl-CoA <=> GTP + Succinate + CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70958", "species_113548", "species_113525" ], "products": [ "species_29374", "species_113573", "species_113536" ], "modifiers": [ [ "species_10504292", "catalyst" ] ], "additional_components": [ "P53596", "WBGene00007350", "P53589", "WBGene00016844" ] }, "reaction_10503561": { "compartment": "compartment_5460", "id": "reaction_10503561", "reactome": "R-CEL-70967", "name": "isocitrate + NAD+ => alpha-ketoglutarate + CO2 + NADH + H+ [IDH3]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113526", "species_29938" ], "products": [ "species_113594", "species_113529", "species_29362", "species_29376" ], "modifiers": [ [ "species_10503558", "catalyst" ], [ "species_113581", "catalyst" ] ], "additional_components": [ "Q20049", "WBGene00009440", "species_266099", "Q93714", "WBGene00009664", "Q93353", "WBGene00007993" ] }, "reaction_10525994": { "compartment": "compartment_5462", "id": "reaction_10525994", "reactome": "R-CEL-450971", "name": "NADPH + NAD+ + H+ [cytosol] => NADP+ + NADH + H+ [mitochondrial matrix]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_113526", "species_113600" ], "products": [ "species_113563", "species_113529", "species_29362" ], "modifiers": [ [ "species_10525991", "catalyst" ] ], "additional_components": [ "Q18031", "WBGene00003778" ] }, "reaction_10570923": { "compartment": "compartment_5460", "id": "reaction_10570923", "reactome": "R-CEL-9012349", "name": "ME3:Mg2+ tetramer oxidatively decarboxylates MAL to PYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113563", "species_113544" ], "products": [ "species_113529", "species_113557", "species_113600", "species_29376" ], "modifiers": [ [ "species_10570920", "catalyst" ] ], "additional_components": [ "Q9U296", "WBGene00012983", "species_114632" ] }, "reaction_10525996": { "compartment": "compartment_5460", "id": "reaction_10525996", "reactome": "R-CEL-450975", "name": "isocitrate <=> citrate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29938" ], "products": [ "species_29654" ], "modifiers": [ [ "species_10503566", "catalyst" ] ], "additional_components": [ "WBGene00000041" ] }, "reaction_10503628": { "compartment": "compartment_5460", "id": "reaction_10503628", "reactome": "R-CEL-70994", "name": "Succinate <=> Fumarate (with FAD redox reaction on enzyme)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113536" ], "products": [ "species_113588" ], "modifiers": [ [ "species_10503625", "catalyst" ] ], "additional_components": [ "P41956", "WBGene00003225", "Q09508", "WBGene00015391", "species_113596", "O62215", "WBGene00009353", "Q09545", "WBGene00006433" ] }, "reaction_10503599": { "compartment": "compartment_5460", "id": "reaction_10503599", "reactome": "R-CEL-70982", "name": "Fumarate + H2O <=> (S)-Malate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113588", "species_113521" ], "products": [ "species_113544" ], "modifiers": [ [ "species_10503596", "catalyst" ] ], "additional_components": [ "O17214", "WBGene00001503" ] }, "reaction_10570899": { "compartment": "compartment_5460", "id": "reaction_10570899", "reactome": "R-CEL-9012268", "name": "ME2:Mg2+ tetramer oxidatively decarboxylates MAL to PYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113544", "species_113526" ], "products": [ "species_113529", "species_113557", "species_29362", "species_29376" ], "modifiers": [ [ "species_10570896", "catalyst" ], [ "species_113588", "catalyst" ], [ "species_113593", "inhibitor" ] ], "additional_components": [ "species_114632", "Q9U296", "WBGene00012983" ] }, "reaction_10503988": { "compartment": "compartment_5460", "id": "reaction_10503988", "reactome": "R-CEL-71401", "name": "alpha-ketoglutarate + CoASH + NAD+ => succinyl-CoA + CO2 + NADH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_113594", "species_113526" ], "products": [ "species_70958", "species_29362", "species_29376" ], "modifiers": [ [ "species_10503711", "catalyst" ] ], "additional_components": [ "O61199", "WBGene00020679", "species_8878387", "CHEBI:17460", "O45148", "WBGene00020950", "O17953", "WBGene00010794", "species_113596" ] }, "reaction_10526006": { "compartment": "compartment_5460", "id": "reaction_10526006", "reactome": "R-CEL-450984", "name": "isocitrate + NADP+ => alpha-ketoglutarate + CO2 + NADPH + H+ [IDH2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113563", "species_29938" ], "products": [ "species_113594", "species_113529", "species_113600", "species_29376" ], "modifiers": [ [ "species_10526003", "catalyst" ] ], "additional_components": [ "O17643", "WBGene00007942", "species_266099" ] }, "reaction_10503579": { "compartment": "compartment_5460", "id": "reaction_10503579", "reactome": "R-CEL-70975", "name": "Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113559", "species_113587", "species_113521" ], "products": [ "species_29374", "species_29654" ], "modifiers": [ [ "species_10503576", "catalyst" ] ], "additional_components": [ "P34575", "WBGene00000833" ] }, "reaction_10503643": { "compartment": "compartment_5460", "id": "reaction_10503643", "reactome": "R-CEL-70997", "name": "ADP + Orthophosphate + Succinyl-CoA <=> ATP + Succinate + CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70958", "species_113548", "species_113581" ], "products": [ "species_29374", "species_113593", "species_113536" ], "modifiers": [ [ "species_10503640", "catalyst" ] ], "additional_components": [ "P53596", "WBGene00007350", "P53588", "WBGene00009812" ] }, "reaction_10570874": { "compartment": "compartment_5460", "id": "reaction_10570874", "reactome": "R-CEL-9012016", "name": "FAHD1:Zn2+ dimer hydrolyses OA to PYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113587" ], "products": [ "species_113557", "species_29376" ], "modifiers": [ [ "species_10570871", "catalyst" ] ], "additional_components": [ "P34673", "WBGene00022798", "species_114632" ] }, "reaction_10528274": { "compartment": "compartment_5460", "id": "reaction_10528274", "reactome": "R-CEL-880002", "name": "(R)-2-hydroxyglutarate + succinate semialdehyde <=> 2-oxoglutarate + 4-hydroxybutyrate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_880046", "species_879997" ], "products": [ "species_113594", "species_880041" ], "modifiers": [ [ "species_10528271", "catalyst" ] ], "additional_components": [ "WBGene00012608" ] }, "reaction_10528292": { "compartment": "compartment_70616", "id": "reaction_10528292", "reactome": "R-CEL-880050", "name": "(S)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113596", "species_880013" ], "products": [ "species_113594", "species_31649" ], "modifiers": [ [ "species_10528289", "catalyst" ] ], "additional_components": [ "WBGene00021564" ] }, "reaction_10528282": { "compartment": "compartment_5460", "id": "reaction_10528282", "reactome": "R-CEL-880007", "name": "(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113596", "species_879997" ], "products": [ "species_113594", "species_31649" ], "modifiers": [ [ "species_10528279", "catalyst" ], [ "species_880069", "catalyst" ], [ "species_880067", "catalyst" ], [ "species_113527", "catalyst" ] ], "additional_components": [ "WBGene00010055" ] }, "reaction_10563171": { "compartment": "compartment_5460", "id": "reaction_10563171", "reactome": "R-CEL-6807826", "name": "LDHAL6B reduces PYR to LACT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113529", "species_113557", "species_29362" ], "products": [ "species_113526", "species_6807616" ], "modifiers": [ [ "species_10563168", "catalyst" ] ], "additional_components": [ "WBGene00002262" ] }, "reaction_10503986": { "compartment": "compartment_5460", "id": "reaction_10503986", "reactome": "R-CEL-71397", "name": "lipo-PDH decarboxylates PYR to Ac-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_113526", "species_113557" ], "products": [ "species_113559", "species_29362", "species_29376" ], "modifiers": [ [ "species_10503983", "catalyst" ] ], "additional_components": [ "P52899", "WBGene00011510", "O44451", "WBGene00015413", "species_8878387", "Q19749", "WBGene00009082", "O17953", "WBGene00010794", "species_113596" ] }, "reaction_10557975": { "compartment": "compartment_70101", "id": "reaction_10557975", "reactome": "R-CEL-6783221", "name": "HAGH hydrolyses (R)-S-LGSH to GSH and LACT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5694130" ], "products": [ "species_29708", "species_29450" ], "modifiers": [ [ "species_10557972", "catalyst" ] ], "additional_components": [ "species_216785", "Q9XXJ1", "WBGene00012459" ] }, "reaction_10503144": { "compartment": "compartment_70101", "id": "reaction_10503144", "reactome": "R-CEL-70510", "name": "LDH tetramer oxidises LACT to PYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29708", "species_29360" ], "products": [ "species_70106", "species_29398", "species_73473" ], "modifiers": [ [ "species_10503141", "catalyst" ] ], "additional_components": [ "Q27888", "WBGene00002262" ] }, "reaction_10570888": { "compartment": "compartment_70101", "id": "reaction_10570888", "reactome": "R-CEL-9012036", "name": "ME1:Mg2+ tetramer oxidatively decarboxylates MAL to PYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29366", "species_198498" ], "products": [ "species_70106", "species_113528", "species_29398", "species_29364" ], "modifiers": [ [ "species_10570885", "catalyst" ] ], "additional_components": [ "species_114632", "Q9U296", "WBGene00012983" ] }, "reaction_10570839": { "compartment": "compartment_5460", "id": "reaction_10570839", "reactome": "R-CEL-9011543", "name": "DCA binds PDK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9010792", "species_10515600" ], "products": [ "species_10515607" ], "modifiers": [], "additional_components": [ "WBGene00022719", "Q02332", "WBGene00022719" ] }, "reaction_10515609": { "compartment": "compartment_5460", "id": "reaction_10515609", "reactome": "R-CEL-203946", "name": "PDK isoforms phosphorylate lipo-PDH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10503983", "species_113593" ], "products": [ "species_113581", "species_10515593" ], "modifiers": [ [ "species_10515598", "catalyst" ], [ "species_29362", "catalyst" ], [ "species_113559", "catalyst" ], [ "species_10514503", "catalyst" ], [ "species_113557", "inhibitor" ], [ "species_10515607", "inhibitor" ] ], "additional_components": [ "P52899", "WBGene00011510", "O44451", "WBGene00015413", "species_8878387", "Q19749", "WBGene00009082", "O17953", "WBGene00010794", "species_113596", "P52899", "WBGene00011510", "O44451", "WBGene00015413", "species_8878387", "Q19749", "WBGene00009082", "O17953", "WBGene00010794", "species_113596", "WBGene00022719", "Q9XUK7", "WBGene00003675", "P41830", "WBGene00004786", "Q10902", "WBGene00003601", "Q20765", "WBGene00003606", "Q9U2R6", "WBGene00003681", "species_5334816", "Q02332", "WBGene00022719" ] }, "reaction_10570846": { "compartment": "compartment_5460", "id": "reaction_10570846", "reactome": "R-CEL-9011595", "name": "GSTZ1 dimer dehalogenates DCA to glyoxylate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9010792", "species_113521" ], "products": [ "species_904849", "species_3301973" ], "modifiers": [ [ "species_10570843", "catalyst" ], [ "species_1655887", "catalyst" ], [ "species_9010792", "inhibitor" ] ], "additional_components": [ "species_1655887", "Q18938", "WBGene00001790" ] }, "reaction_10515983": { "compartment": "compartment_5460", "id": "reaction_10515983", "reactome": "R-CEL-204169", "name": "PDP dephosphorylates p-lipo-PDH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10515593", "species_113521" ], "products": [ "species_10503983", "species_113548" ], "modifiers": [ [ "species_10515980", "catalyst" ], [ "species_109496", "catalyst" ] ], "additional_components": [ "P52899", "WBGene00011510", "O44451", "WBGene00015413", "species_8878387", "Q19749", "WBGene00009082", "O17953", "WBGene00010794", "species_113596", "P52899", "WBGene00011510", "O44451", "WBGene00015413", "species_8878387", "Q19749", "WBGene00009082", "O17953", "WBGene00010794", "species_113596", "Q9U300", "WBGene00013718", "species_113596", "Q9N4M0", "WBGene00022832" ] }, "reaction_10504332": { "compartment": "compartment_70101", "id": "reaction_10504332", "reactome": "R-CEL-71849", "name": "LDH tetramer reduces PYR to LACT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29398", "species_73473" ], "products": [ "species_29708", "species_29360" ], "modifiers": [ [ "species_10503141", "catalyst" ] ], "additional_components": [ "Q27888", "WBGene00002262" ] }, "reaction_10570926": { "compartment": "compartment_70101", "id": "reaction_10570926", "reactome": "R-CEL-9012374", "name": "VDAC1 transports PYR from cytosol to mitochondrial intermembrane space", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29398" ], "products": [ "species_9012375" ], "modifiers": [ [ "species_10550419", "catalyst" ] ], "additional_components": [ "WBGene00019900" ] }, "reaction_10532289": { "compartment": "compartment_70101", "id": "reaction_10532289", "reactome": "R-CEL-1237096", "name": "Methylthio-ribose-P = Methylthio-ribulose-P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1237165" ], "products": [ "species_1237107" ], "modifiers": [ [ "species_10532286", "catalyst" ] ], "additional_components": [ "WBGene00007236" ] }, "reaction_10532309": { "compartment": "compartment_70101", "id": "reaction_10532309", "reactome": "R-CEL-1237129", "name": "Acireductone is created", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1237176" ], "products": [ "species_29372", "species_70106", "species_1237155" ], "modifiers": [ [ "species_10532306", "catalyst" ] ], "additional_components": [ "Q21012", "WBGene00010286", "species_114632" ] }, "reaction_10532299": { "compartment": "compartment_70101", "id": "reaction_10532299", "reactome": "R-CEL-1237119", "name": "Acireductone is oxidized to MOB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_1237155" ], "products": [ "species_29460", "species_1237122" ], "modifiers": [ [ "species_10532296", "catalyst" ] ], "additional_components": [ "Q20340", "WBGene00009636", "species_113531" ] }, "reaction_10532319": { "compartment": "compartment_70101", "id": "reaction_10532319", "reactome": "R-CEL-1237160", "name": "MTA is cleaved and phosphorylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29372", "species_353106" ], "products": [ "species_1237165", "species_83951" ], "modifiers": [ [ "species_10532316", "catalyst" ] ], "additional_components": [ "Q09438", "WBGene00015064" ] }, "reaction_10510738": { "compartment": "compartment_70616", "id": "reaction_10510738", "reactome": "R-CEL-166214", "name": "FA anion flip-flops to the opposite surface", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10510733" ], "products": [ "species_10510735" ], "modifiers": [ [ "species_10510733", "catalyst" ] ], "additional_components": [ "species_166216", "O01883", "WBGene00006729", "species_166216", "O01883", "WBGene00006729", "species_166216", "O01883", "WBGene00006729" ] }, "reaction_10510740": { "compartment": "compartment_70616", "id": "reaction_10510740", "reactome": "R-CEL-166220", "name": "FA anion diffuses laterally to UCP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10510731", "species_166213" ], "products": [ "species_10510733" ], "modifiers": [], "additional_components": [ "O01883", "WBGene00006729", "species_166216", "O01883", "WBGene00006729" ] }, "reaction_10510742": { "compartment": "compartment_70616", "id": "reaction_10510742", "reactome": "R-CEL-166387", "name": "The FA anion diffuses away laterally from UCP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10510735" ], "products": [ "species_10510731", "species_166216" ], "modifiers": [], "additional_components": [ "species_166216", "O01883", "WBGene00006729", "O01883", "WBGene00006729" ] }, "reaction_10511077": { "compartment": "compartment_70616", "id": "reaction_10511077", "reactome": "R-CEL-170026", "name": "Protons are translocated from the intermembrane space to the matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_163953" ], "products": [ "species_113529" ], "modifiers": [ [ "species_10510731", "catalyst" ], [ "species_30495", "catalyst" ], [ "species_170037", "inhibitor" ] ], "additional_components": [ "O01883", "WBGene00006729", "species_29358", "species_113582", "species_29420", "species_29438" ] }, "reaction_10567812": { "compartment": "compartment_7660", "id": "reaction_10567812", "reactome": "R-CEL-8878143", "name": "RUNX3 binds SMAD3 and SMAD4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10566205", "species_10567808" ], "products": [ "species_10567810" ], "modifiers": [], "additional_components": [ "WBGene00004393", "P45897", "WBGene00004858", "Q21733", "WBGene00000904", "P45897", "WBGene00004858", "Q21733", "WBGene00000904", "G5EFQ5", "WBGene00004393" ] }, "reaction_10567805": { "compartment": "compartment_7660", "id": "reaction_10567805", "reactome": "R-CEL-8878117", "name": "RUNX3 binds ZFHX3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10566205", "species_10567801" ], "products": [ "species_10567803" ], "modifiers": [ [ "species_10511431", "catalyst" ] ], "additional_components": [ "WBGene00004393", "WBGene00022518", "V6CLN5", "WBGene00022518", "G5EFQ5", "WBGene00004393", "G5EBY8", "WBGene00006852", "G5EEL5", "WBGene00000936" ] }, "reaction_10520769": { "compartment": "compartment_17951", "id": "reaction_10520769", "reactome": "R-CEL-390256", "name": "hexacosanoyl-CoA + O2 => trans-2,3-dehydrohexacosanoyl-CoA + H2O2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113535", "species_390260" ], "products": [ "species_390249", "species_113575" ], "modifiers": [ [ "species_10520766", "catalyst" ] ], "additional_components": [ "species_113596", "O62138", "WBGene00008566" ] }, "reaction_10520758": { "compartment": "compartment_17951", "id": "reaction_10520758", "reactome": "R-CEL-390251", "name": "HSD17B4 dehydrogenates 3-hydroxyhexacosanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_390248", "species_192307" ], "products": [ "species_193465", "species_390241", "species_192305" ], "modifiers": [ [ "species_10513270", "catalyst" ] ], "additional_components": [ "Q19058", "WBGene00017123" ] }, "reaction_10520808": { "compartment": "compartment_17947", "id": "reaction_10520808", "reactome": "R-CEL-390393", "name": "Peroxisomal uptake of very long-chain fatty acyl CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_390394" ], "products": [ "species_390260" ], "modifiers": [ [ "species_10520381", "catalyst" ] ], "additional_components": [ "O45730", "WBGene00004061" ] }, "reaction_10520760": { "compartment": "compartment_17951", "id": "reaction_10520760", "reactome": "R-CEL-390252", "name": "HSD17B4 hydrates trans-2,3-dehydrohexacosanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_141343", "species_390249" ], "products": [ "species_390248" ], "modifiers": [ [ "species_10513270", "catalyst" ] ], "additional_components": [ "Q19058", "WBGene00017123" ] }, "reaction_10563641": { "compartment": "compartment_17951", "id": "reaction_10563641", "reactome": "R-CEL-6809263", "name": "EHHADH hydrates trans-2,3-dehydrohexacosanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_141343", "species_390249" ], "products": [ "species_390248" ], "modifiers": [ [ "species_10563638", "catalyst" ] ], "additional_components": [ "WBGene00001157" ] }, "reaction_10556490": { "compartment": "compartment_17951", "id": "reaction_10556490", "reactome": "R-CEL-5690042", "name": "Peroxisomal ACOT4,6,8 hydrolyse MCFA-CoA, LCFA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5690520", "species_141343" ], "products": [ "species_5690539", "species_193514" ], "modifiers": [ [ "species_10556487", "catalyst" ] ], "additional_components": [ "species_164991", "species_5690542", "species_5690531", "species_174602", "O45003", "WBGene00020989", "Q9GYN3", "WBGene00020989", "B3WFZ3", "WBGene00020989", "O01862", "WBGene00020989", "Q9BIA9", "WBGene00015887" ] }, "reaction_10530620": { "compartment": "compartment_17951", "id": "reaction_10530620", "reactome": "R-CEL-977317", "name": "malonyl-CoA is decarboxylated to acetyl-CoA in peroxisome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_977323" ], "products": [ "species_353123", "species_389536" ], "modifiers": [ [ "species_10530617", "catalyst" ] ], "additional_components": [ "WBGene00009439" ] }, "reaction_10563644": { "compartment": "compartment_17951", "id": "reaction_10563644", "reactome": "R-CEL-6809264", "name": "EHHADH dehydrogenates 3-hydroxyhexacosanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_390248", "species_192307" ], "products": [ "species_193465", "species_390241", "species_192305" ], "modifiers": [ [ "species_10563638", "catalyst" ] ], "additional_components": [ "WBGene00001157" ] }, "reaction_10520641": { "compartment": "compartment_17951", "id": "reaction_10520641", "reactome": "R-CEL-389632", "name": "pristanate + CoA-SH + ATP => pristanoyl-CoA + AMP + pyrophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6811612", "species_193514", "species_389573" ], "products": [ "species_389593", "species_389569", "species_389620" ], "modifiers": [ [ "species_10520635", "catalyst" ] ], "additional_components": [ "Q18916", "WBGene00017012", "Q19878", "WBGene00009218" ] }, "reaction_10520629": { "compartment": "compartment_17951", "id": "reaction_10520629", "reactome": "R-CEL-389611", "name": "2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_389594" ], "products": [ "species_389578", "species_389636" ], "modifiers": [ [ "species_10520626", "catalyst" ] ], "additional_components": [ "species_8878387", "species_114632", "Q17474", "WBGene00007143" ] }, "reaction_10520617": { "compartment": "compartment_17951", "id": "reaction_10520617", "reactome": "R-CEL-389609", "name": "ALDH3A2-2 oxidizes pristanal to pristanate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_389636", "species_192307" ], "products": [ "species_193465", "species_6811612", "species_192305" ], "modifiers": [ [ "species_10520614", "catalyst" ] ], "additional_components": [ "O44555", "WBGene00000111", "A0A486WWU7", "WBGene00000110" ] }, "reaction_10520651": { "compartment": "compartment_17951", "id": "reaction_10520651", "reactome": "R-CEL-389639", "name": "phytanoyl-CoA + 2-oxoglutarate + O2 => 2-hydroxyphytanoyl-CoA + succinate + CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113535", "species_389615", "species_389537" ], "products": [ "species_389594", "species_389583", "species_389536" ], "modifiers": [ [ "species_10520648", "catalyst" ] ], "additional_components": [ "O62515", "WBGene00014000", "species_113531" ] }, "reaction_10520638": { "compartment": "compartment_17951", "id": "reaction_10520638", "reactome": "R-CEL-389622", "name": "phytanate + CoA-SH + ATP => phytanoyl-CoA + AMP + pyrophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_389596", "species_193514", "species_389573" ], "products": [ "species_389593", "species_389615", "species_389620" ], "modifiers": [ [ "species_10520635", "catalyst" ] ], "additional_components": [ "Q18916", "WBGene00017012", "Q19878", "WBGene00009218" ] }, "reaction_10564665": { "compartment": "compartment_17947", "id": "reaction_10564665", "reactome": "R-CEL-8848247", "name": "ACBD4,5 bind MCFA-CoA and LCFA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5690520", "species_10564661" ], "products": [ "species_10564663" ], "modifiers": [], "additional_components": [ "species_164991", "species_5690542", "A0A1D3PCN1", "WBGene00270319", "Q9XTZ5", "WBGene00007680", "A0A1D3PCN1", "WBGene00270319", "Q9XTZ5", "WBGene00007680", "species_164991", "species_5690542" ] }, "reaction_10558271": { "compartment": "compartment_17951", "id": "reaction_10558271", "reactome": "R-CEL-6787811", "name": "HAO2 tetramer oxidises 2OH-PALM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113535", "species_6787810" ], "products": [ "species_113575", "species_6787814" ], "modifiers": [ [ "species_10558268", "catalyst" ] ], "additional_components": [ "B1GRK5", "WBGene00018286" ] }, "reaction_10563806": { "compartment": "compartment_17951", "id": "reaction_10563806", "reactome": "R-CEL-6810474", "name": "NUDT19 hydrolyses acyl-CoA to 3',5'-ADP and acyl-PPANT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_141343", "species_6810523" ], "products": [ "species_6809360", "species_6810530" ], "modifiers": [ [ "species_10563803", "catalyst" ] ], "additional_components": [ "WBGene00003584" ] }, "reaction_10516209": { "compartment": "compartment_70101", "id": "reaction_10516209", "reactome": "R-CEL-205136", "name": "GTP-bound RAC contributes to JNK activation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10510931" ], "products": [ "species_29370", "species_10510951" ], "modifiers": [ [ "species_10516065", "catalyst" ] ], "additional_components": [ "WBGene00002178", "WBGene00002178", "Q03206", "ced-10", "species_29438" ] }, "reaction_10516179": { "compartment": "compartment_70101", "id": "reaction_10516179", "reactome": "R-CEL-205039", "name": "p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10516063", "species_29438" ], "products": [ "species_29420", "species_10516065" ], "modifiers": [ [ "species_10516176", "catalyst" ] ], "additional_components": [ "species_29420", "Q03206", "ced-10", "Q03206", "ced-10", "species_29438", "G5EFE1", "WBGene00006468", "H2L0P5", "WBGene00022391", "G5EF62", "WBGene00009337", "Q9U3P2", "WBGene00007750", "X5LV34", "WBGene00001366", "S6EZU2", "WBGene00006476", "Q45FX5", "WBGene00006887", "Q21653", "WBGene00019832", "A0A0K3AQN0", "WBGene00013682", "O01847", "WBGene00015704", "Q965J0", "WBGene00019487", "Q21430", "WBGene00010776", "H2KYI7", "WBGene00006496", "Q9N5D3", "WBGene00004947", "Q9U364", "WBGene00002297", "A0A0K3AS36", "Y116A8C.36d", "Q19572", "WBGene00001674", "species_29438" ] }, "reaction_10513418": { "compartment": "compartment_13231", "id": "reaction_10513418", "reactome": "R-CEL-193666", "name": "Active JNK moves to the nucleus and phosphorylates different transcription factors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10510951" ], "products": [ "species_10510872" ], "modifiers": [], "additional_components": [ "WBGene00002178", "WBGene00002178" ] }, "reaction_10523262": { "compartment": "compartment_70101", "id": "reaction_10523262", "reactome": "R-CEL-428750", "name": "Gq activation by TP receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10523257" ], "products": [ "species_29420", "species_10523259" ], "modifiers": [ [ "species_10523257", "catalyst" ] ], "additional_components": [ "CHEBI:15627", "species_29420", "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "CHEBI:15627", "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196", "species_29438", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "CHEBI:15627", "species_29420", "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196", "P17343", "WBGene00001679", "P54406", "WBGene00001681" ] }, "reaction_10523342": { "compartment": "compartment_70101", "id": "reaction_10523342", "reactome": "R-CEL-428917", "name": "G13 activation by TP receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10523337" ], "products": [ "species_29420", "species_10523339" ], "modifiers": [ [ "species_10523337", "catalyst" ] ], "additional_components": [ "species_29420", "Q19572", "WBGene00001674", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "CHEBI:15627", "CHEBI:15627", "Q19572", "WBGene00001674", "species_29438", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "species_29420", "Q19572", "WBGene00001674", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "CHEBI:15627" ] }, "reaction_10546012": { "compartment": "compartment_7660", "id": "reaction_10546012", "reactome": "R-CEL-2990833", "name": "Conjugation of SUMO1 to UBA2:SAE1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10545999", "species_29358", "species_10528096" ], "products": [ "species_164121", "species_10546009", "species_113541" ], "modifiers": [ [ "species_10545999", "catalyst" ] ], "additional_components": [ "Q17820", "WBGene00000142", "Q9NAN1", "WBGene00006700", "WBGene00004888", "Q9NAN1", "WBGene00006700", "P55853", "WBGene00004888", "Q17820", "WBGene00000142", "Q17820", "WBGene00000142", "Q9NAN1", "WBGene00006700" ] }, "reaction_10546368": { "compartment": "compartment_7660", "id": "reaction_10546368", "reactome": "R-CEL-3108212", "name": "SMC5-SMC6 Complex SUMOylates Cohesin with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10544476", "species_10546081" ], "products": [ "species_10546332", "species_10546073" ], "modifiers": [ [ "species_10546365", "catalyst" ] ], "additional_components": [ "B2FDA8", "WBGene00004873", "Q19325", "WBGene00004737", "Q9XUB3", "WBGene00004333", "Q19555", "WBGene00004738", "O01789", "WBGene00001860", "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "B2FDA8", "WBGene00004873", "Q19325", "WBGene00004737", "Q9XUB3", "WBGene00004333", "P55853", "WBGene00004888", "Q19555", "WBGene00004738", "O01789", "WBGene00001860", "WBGene00006706", "G5EG17", "WBGene00010056", "P91501", "WBGene00020843", "Q23420", "WBGene00022881", "Q9XTV3", "WBGene00010409", "Q18237", "WBGene00016151" ] }, "reaction_10549336": { "compartment": "compartment_7660", "id": "reaction_10549336", "reactome": "R-CEL-4570554", "name": "SUMOylation of MDC1 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10549326", "species_10546081" ], "products": [ "species_10546073", "species_10549334" ], "modifiers": [ [ "species_10546081", "catalyst" ] ], "additional_components": [ "WBGene00004031", "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "WBGene00006706", "P55853", "WBGene00004888", "Q9U370", "WBGene00004031", "Q95017", "WBGene00006706", "P55853", "WBGene00004888" ] }, "reaction_10549321": { "compartment": "compartment_7660", "id": "reaction_10549321", "reactome": "R-CEL-4570528", "name": "SUMOylation of XPC with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10549311", "species_10546081" ], "products": [ "species_10546073", "species_10549319" ], "modifiers": [ [ "species_10546081", "catalyst" ] ], "additional_components": [ "WBGene00022296", "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "WBGene00006706", "Q9N4C3", "WBGene00022296", "P55853", "WBGene00004888", "Q95017", "WBGene00006706", "P55853", "WBGene00004888" ] }, "reaction_10546235": { "compartment": "compartment_7660", "id": "reaction_10546235", "reactome": "R-CEL-3000383", "name": "UBE2I, HDAC7 SUMOylate PML with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546215", "species_10546081" ], "products": [ "species_10546073", "species_10546225" ], "modifiers": [ [ "species_10546232", "catalyst" ] ], "additional_components": [ "WBGene00006523", "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "WBGene00006706", "G5ED20", "WBGene00006523", "P55853", "WBGene00004888", "O17323", "WBGene00001837", "Q95017", "WBGene00006706" ] }, "reaction_10549243": { "compartment": "compartment_7660", "id": "reaction_10549243", "reactome": "R-CEL-4551661", "name": "PIAS4 SUMOylates RNF168 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546081", "species_10549233" ], "products": [ "species_10546073", "species_10549241" ], "modifiers": [ [ "species_10546168", "catalyst" ] ], "additional_components": [ "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "WBGene00011366", "WBGene00006706", "P55853", "WBGene00004888", "Q7YWU1", "WBGene00011366", "Q21970", "WBGene00011259", "Q94361", "WBGene00001574" ] }, "reaction_10546173": { "compartment": "compartment_7660", "id": "reaction_10546173", "reactome": "R-CEL-2997709", "name": "PIAS1,4 SUMOylates BRCA1 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546154", "species_10546081" ], "products": [ "species_10546073", "species_10546162" ], "modifiers": [ [ "species_10546170", "catalyst" ] ], "additional_components": [ "WBGene00000264", "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "WBGene00006706", "P55853", "WBGene00004888", "B6VQ60", "WBGene00000264", "Q21970", "WBGene00011259", "Q94361", "WBGene00001574" ] }, "reaction_10549255": { "compartment": "compartment_7660", "id": "reaction_10549255", "reactome": "R-CEL-4551721", "name": "PIAS4 SUMOylates VHL with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10532238", "species_10546081" ], "products": [ "species_10546073", "species_10549253" ], "modifiers": [ [ "species_10546168", "catalyst" ] ], "additional_components": [ "WBGene00006922", "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "WBGene00006706", "Q19213", "WBGene00006922", "P55853", "WBGene00004888", "Q21970", "WBGene00011259", "Q94361", "WBGene00001574" ] }, "reaction_10546769": { "compartment": "compartment_7660", "id": "reaction_10546769", "reactome": "R-CEL-3247493", "name": "PIAS1 SUMOylates SP3 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546758", "species_10546081" ], "products": [ "species_10546766", "species_10546073" ], "modifiers": [ [ "species_10528091", "catalyst" ] ], "additional_components": [ "WBGene00012735", "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "Q9XW26", "WBGene00012735", "P55853", "WBGene00004888", "WBGene00006706", "Q21970", "WBGene00011259", "Q94361", "WBGene00001574" ] }, "reaction_10546189": { "compartment": "compartment_7660", "id": "reaction_10546189", "reactome": "R-CEL-2997723", "name": "PIAS4 SUMOylates TP53BP1 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546178", "species_10546081" ], "products": [ "species_10546186", "species_10546073" ], "modifiers": [ [ "species_10546168", "catalyst" ] ], "additional_components": [ "WBGene00002027", "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "Q7JKP6", "WBGene00002027", "P55853", "WBGene00004888", "WBGene00006706", "Q21970", "WBGene00011259", "Q94361", "WBGene00001574" ] }, "reaction_10546734": { "compartment": "compartment_7660", "id": "reaction_10546734", "reactome": "R-CEL-3232162", "name": "PIAS3 SUMOylates MITF with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546716", "species_10546081" ], "products": [ "species_10546073", "species_10546725" ], "modifiers": [ [ "species_10546731", "catalyst" ] ], "additional_components": [ "WBGene00020930", "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "WBGene00006706", "H2KZZ2", "WBGene00020930", "P55853", "WBGene00004888", "Q21970", "WBGene00011259", "Q94361", "WBGene00001574" ] }, "reaction_10549296": { "compartment": "compartment_7660", "id": "reaction_10549296", "reactome": "R-CEL-4570467", "name": "SUMOylation of NOP58 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10549285", "species_10546081" ], "products": [ "species_10549294", "species_10546073" ], "modifiers": [ [ "species_10546081", "catalyst" ] ], "additional_components": [ "WBGene00020915", "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "P55853", "WBGene00004888", "O45012", "WBGene00020915", "WBGene00006706", "Q95017", "WBGene00006706", "P55853", "WBGene00004888" ] }, "reaction_10548368": { "compartment": "compartment_7660", "id": "reaction_10548368", "reactome": "R-CEL-3900177", "name": "SUMOylation of DDX5 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10504695", "species_10546081" ], "products": [ "species_10548366", "species_10546073" ], "modifiers": [ [ "species_10546081", "catalyst" ] ], "additional_components": [ "WBGene00010260", "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "P55853", "WBGene00004888", "Q9XUW5", "WBGene00010260", "WBGene00006706", "Q95017", "WBGene00006706", "P55853", "WBGene00004888" ] }, "reaction_10548945": { "compartment": "compartment_7660", "id": "reaction_10548945", "reactome": "R-CEL-4085331", "name": "PIAS2-1 SUMOylates PARK7 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10548932", "species_10546081" ], "products": [ "species_10548940", "species_10546073" ], "modifiers": [ [ "species_10548942", "catalyst" ] ], "additional_components": [ "WBGene00015184", "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "P55853", "WBGene00004888", "P90994", "WBGene00015184", "WBGene00006706", "WBGene00001574" ] }, "reaction_10548961": { "compartment": "compartment_7660", "id": "reaction_10548961", "reactome": "R-CEL-4085347", "name": "PIAS1 SUMOylates SAFB with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10548950", "species_10546081" ], "products": [ "species_10548959", "species_10546073" ], "modifiers": [ [ "species_10528091", "catalyst" ] ], "additional_components": [ "WBGene00009314", "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "P55853", "WBGene00004888", "O62203", "WBGene00009314", "WBGene00006706", "Q21970", "WBGene00011259", "Q94361", "WBGene00001574" ] }, "reaction_10549026": { "compartment": "compartment_7660", "id": "reaction_10549026", "reactome": "R-CEL-4090284", "name": "SUMOylation of HIPK2 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10549016", "species_10546081" ], "products": [ "species_10546073", "species_10549024" ], "modifiers": [ [ "species_10546081", "catalyst" ] ], "additional_components": [ "WBGene00001994", "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "WBGene00006706", "P55853", "WBGene00004888", "Q8MQ70", "WBGene00001994", "Q95017", "WBGene00006706", "P55853", "WBGene00004888" ] }, "reaction_10548179": { "compartment": "compartment_7660", "id": "reaction_10548179", "reactome": "R-CEL-3782535", "name": "TRIM28 SUMOylates TRIM28:ZNF350 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10548151", "species_10546081" ], "products": [ "species_10546073", "species_10548176" ], "modifiers": [ [ "species_10529660", "catalyst" ] ], "additional_components": [ "Q9N5S3", "WBGene00003087", "O46016", "WBGene00013970", "B7WNA2", "WBGene00010264", "Q19418", "WBGene00008762", "H2L008", "WBGene00019960", "Q9BLC4", "WBGene00017406", "O02050", "WBGene00022592", "H2L0K3", "WBGene00003599", "Q19818", "WBGene00003598", "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "WBGene00006706", "Q9N5S3", "WBGene00003087", "O46016", "WBGene00013970", "B7WNA2", "WBGene00010264", "Q19418", "WBGene00008762", "H2L008", "WBGene00019960", "Q9BLC4", "WBGene00017406", "O02050", "WBGene00022592", "Q19818", "WBGene00003598", "H2L0K3", "WBGene00003599", "P55853", "WBGene00004888", "H2L0K3", "WBGene00003599", "Q19818", "WBGene00003598" ] }, "reaction_10548358": { "compartment": "compartment_7660", "id": "reaction_10548358", "reactome": "R-CEL-3900047", "name": "SUMOylation of DDX17 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10548348", "species_10546081" ], "products": [ "species_10546073", "species_10548356" ], "modifiers": [ [ "species_10546081", "catalyst" ] ], "additional_components": [ "WBGene00010260", "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "WBGene00006706", "Q9XUW5", "WBGene00010260", "P55853", "WBGene00004888", "Q95017", "WBGene00006706", "P55853", "WBGene00004888" ] }, "reaction_10548346": { "compartment": "compartment_7660", "id": "reaction_10548346", "reactome": "R-CEL-3899291", "name": "SUMOylation of EP300 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10532228", "species_10546081" ], "products": [ "species_10546073", "species_10548344" ], "modifiers": [ [ "species_10546081", "catalyst" ] ], "additional_components": [ "WBGene00000366", "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "WBGene00006706", "P55853", "WBGene00004888", "P34545", "WBGene00000366", "Q95017", "WBGene00006706", "P55853", "WBGene00004888" ] }, "reaction_10549506": { "compartment": "compartment_7660", "id": "reaction_10549506", "reactome": "R-CEL-4641362", "name": "SUMOylation of TOP1 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10549496", "species_10546081" ], "products": [ "species_10546073", "species_10549504" ], "modifiers": [ [ "species_10546081", "catalyst" ] ], "additional_components": [ "WBGene00006595", "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "WBGene00006706", "O17966", "WBGene00006595", "P55853", "WBGene00004888", "Q95017", "WBGene00006706", "P55853", "WBGene00004888" ] }, "reaction_10549491": { "compartment": "compartment_7660", "id": "reaction_10549491", "reactome": "R-CEL-4641345", "name": "SUMOylation of TOP2B with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10549474", "species_10546081" ], "products": [ "species_10546073", "species_10549489" ], "modifiers": [ [ "species_10546081", "catalyst" ] ], "additional_components": [ "Q23670", "WBGene00010785", "G5ECQ8", "WBGene00022854", "P34534", "WBGene00019884", "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "WBGene00006706", "G5ECQ8", "WBGene00022854", "P34534", "WBGene00019884", "Q23670", "WBGene00010785", "P55853", "WBGene00004888", "Q95017", "WBGene00006706", "P55853", "WBGene00004888" ] }, "reaction_10549460": { "compartment": "compartment_7660", "id": "reaction_10549460", "reactome": "R-CEL-4641342", "name": "SUMOylation of TOP2A with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10549450", "species_10546081" ], "products": [ "species_10546073", "species_10549458" ], "modifiers": [ [ "species_10546081", "catalyst" ] ], "additional_components": [ "WBGene00019884", "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "WBGene00006706", "P55853", "WBGene00004888", "P34534", "WBGene00019884", "Q95017", "WBGene00006706", "P55853", "WBGene00004888" ] }, "reaction_10549415": { "compartment": "compartment_7660", "id": "reaction_10549415", "reactome": "R-CEL-4615910", "name": "SUMOylation of PCNA with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502651", "species_10546081" ], "products": [ "species_10546073", "species_10549413" ], "modifiers": [ [ "species_10546081", "catalyst" ] ], "additional_components": [ "WBGene00003955", "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "WBGene00006706", "O02115", "WBGene00003955", "P55853", "WBGene00004888", "Q95017", "WBGene00006706", "P55853", "WBGene00004888" ] }, "reaction_10548917": { "compartment": "compartment_7660", "id": "reaction_10548917", "reactome": "R-CEL-3968362", "name": "SUMOylation of PIAS4 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546168", "species_10546081" ], "products": [ "species_10546073", "species_10548915" ], "modifiers": [ [ "species_10546081", "catalyst" ] ], "additional_components": [ "Q21970", "WBGene00011259", "Q94361", "WBGene00001574", "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "WBGene00006706", "Q21970", "WBGene00011259", "Q94361", "WBGene00001574", "P55853", "WBGene00004888", "Q95017", "WBGene00006706", "P55853", "WBGene00004888" ] }, "reaction_10548971": { "compartment": "compartment_7660", "id": "reaction_10548971", "reactome": "R-CEL-4085350", "name": "SUMOylation of UBE2I with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546073", "species_10546081" ], "products": [ "species_10546073", "species_10548969" ], "modifiers": [ [ "species_10546081", "catalyst" ] ], "additional_components": [ "WBGene00006706", "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "WBGene00006706", "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "Q95017", "WBGene00006706", "P55853", "WBGene00004888" ] }, "reaction_10546255": { "compartment": "compartment_13231", "id": "reaction_10546255", "reactome": "R-CEL-3000449", "name": "UBC9 (UBE2I) SUMOylates RANGAP1 with SUMO, which targets RANGAP1 to RANBP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546242", "species_10546081" ], "products": [ "species_10546252", "species_10546073" ], "modifiers": [ [ "species_10546081", "catalyst" ] ], "additional_components": [ "P34342", "WBGene00004303", "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "P34342", "WBGene00004303", "P55853", "WBGene00004888", "WBGene00006706", "Q95017", "WBGene00006706", "P55853", "WBGene00004888" ] }, "reaction_10509888": { "compartment": "compartment_70101", "id": "reaction_10509888", "reactome": "R-CEL-156808", "name": "Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a 'closed-loop' conformation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10505614", "species_10509884", "species_10509879", "species_10505637" ], "products": [ "species_10505614", "species_10509886" ], "modifiers": [], "additional_components": [ "WBGene00019162", "WBGene00003902", "A0A486WX07", "WBGene00002066", "Q20935", "WBGene00018997", "P27639", "WBGene00002083", "O61955", "WBGene00002061", "H2L0A8", "WBGene00019157", "species_29438", "Q9BKU3", "WBGene00021351", "Q21230", "WBGene00010560", "Q95XR0", "WBGene00021466", "P51403", "WBGene00004471", "Q9NEN6", "WBGene00004475", "Q8WQA8", "WBGene00004489", "Q23312", "WBGene00004476", "O01869", "WBGene00004479", "P49197", "WBGene00004490", "P48156", "WBGene00004477", "Q20206", "WBGene00004480", "Q19877", "WBGene00004492", "Q20228", "WBGene00004478", "P49196", "WBGene00004481", "Q1XFY9", "WBGene00004493", "P46769", "WBGene00004469", "P51404", "WBGene00004482", "P52821", "WBGene00004494", "Q9TXP0", "WBGene00004496", "P48150", "WBGene00004483", "O45499", "WBGene00004495", "Q9N3X2", "WBGene00004473", "Q9XVP0", "WBGene00004484", "Q95Y04", "WBGene00004497", "Q22054", "WBGene00004485", "P90983", "WBGene00004498", "O01692", "WBGene00004486", "P48152", "WBGene00004472", "O18240", "WBGene00004487", "O18650", "WBGene00004488", "P48154", "WBGene00004470", "O17218", "WBGene00004491", "P49041", "WBGene00004474", "Q95QW0", "WBGene00015920", "O01974", "WBGene00001231", "Q94261", "WBGene00019543", "P34339", "WBGene00001209", "Q9XWP7", "WBGene00012738", "P30642", "WBGene00001227", "Q965S8", "WBGene00001232", "O02328", "WBGene00001226", "Q19706", "WBGene00001230", "O61820", "WBGene00001228", "Q18967", "WBGene00001229", "Q9XUP3", "WBGene00001233", "Q9XWI6", "WBGene00001225", "Q9TXU7", "WBGene00019162", "WBGene00019162", "A0A486WX07", "WBGene00002066", "Q20935", "WBGene00018997", "P27639", "WBGene00002083", "O61955", "WBGene00002061", "species_29438", "Q9BKU3", "WBGene00021351", "Q21230", "WBGene00010560", "Q95XR0", "WBGene00021466", "P51403", "WBGene00004471", "Q9NEN6", "WBGene00004475", "Q8WQA8", "WBGene00004489", "Q23312", "WBGene00004476", "O01869", "WBGene00004479", "P49197", "WBGene00004490", "P48156", "WBGene00004477", "Q20206", "WBGene00004480", "Q19877", "WBGene00004492", "Q20228", "WBGene00004478", "P49196", "WBGene00004481", "Q1XFY9", "WBGene00004493", "P46769", "WBGene00004469", "P51404", "WBGene00004482", "P52821", "WBGene00004494", "Q9TXP0", "WBGene00004496", "P48150", "WBGene00004483", "O45499", "WBGene00004495", "Q9N3X2", "WBGene00004473", "Q9XVP0", "WBGene00004484", "Q95Y04", "WBGene00004497", "Q22054", "WBGene00004485", "P90983", "WBGene00004498", "O01692", "WBGene00004486", "P48152", "WBGene00004472", "O18240", "WBGene00004487", "O18650", "WBGene00004488", "P48154", "WBGene00004470", "O17218", "WBGene00004491", "P49041", "WBGene00004474", "Q95QW0", "WBGene00015920", "O01974", "WBGene00001231", "Q94261", "WBGene00019543", "P34339", "WBGene00001209", "Q9XWP7", "WBGene00012738", "P30642", "WBGene00001227", "Q965S8", "WBGene00001232", "O02328", "WBGene00001226", "Q19706", "WBGene00001230", "O61820", "WBGene00001228", "Q18967", "WBGene00001229", "Q9XUP3", "WBGene00001233", "Q9XWI6", "WBGene00001225", "Q9TXU7", "WBGene00019162", "H2L0A8", "WBGene00019157", "Q9U302", "WBGene00003902" ] }, "reaction_10509927": { "compartment": "compartment_70101", "id": "reaction_10509927", "reactome": "R-CEL-157849", "name": "Formation of translation initiation complexes containing mRNA that does not circularize", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10505614", "species_10509925", "species_10505637" ], "products": [ "species_10505614", "species_10505676" ], "modifiers": [], "additional_components": [ "WBGene00019162", "A0A486WX07", "WBGene00002066", "Q20935", "WBGene00018997", "P27639", "WBGene00002083", "O61955", "WBGene00002061", "H2L0A8", "WBGene00019157", "species_29438", "Q9BKU3", "WBGene00021351", "Q21230", "WBGene00010560", "Q95XR0", "WBGene00021466", "P51403", "WBGene00004471", "Q9NEN6", "WBGene00004475", "Q8WQA8", "WBGene00004489", "Q23312", "WBGene00004476", "O01869", "WBGene00004479", "P49197", "WBGene00004490", "P48156", "WBGene00004477", "Q20206", "WBGene00004480", "Q19877", "WBGene00004492", "Q20228", "WBGene00004478", "P49196", "WBGene00004481", "Q1XFY9", "WBGene00004493", "P46769", "WBGene00004469", "P51404", "WBGene00004482", "P52821", "WBGene00004494", "Q9TXP0", "WBGene00004496", "P48150", "WBGene00004483", "O45499", "WBGene00004495", "Q9N3X2", "WBGene00004473", "Q9XVP0", "WBGene00004484", "Q95Y04", "WBGene00004497", "Q22054", "WBGene00004485", "P90983", "WBGene00004498", "O01692", "WBGene00004486", "P48152", "WBGene00004472", "O18240", "WBGene00004487", "O18650", "WBGene00004488", "P48154", "WBGene00004470", "O17218", "WBGene00004491", "P49041", "WBGene00004474", "Q95QW0", "WBGene00015920", "O01974", "WBGene00001231", "Q94261", "WBGene00019543", "P34339", "WBGene00001209", "Q9XWP7", "WBGene00012738", "P30642", "WBGene00001227", "Q965S8", "WBGene00001232", "O02328", "WBGene00001226", "Q19706", "WBGene00001230", "O61820", "WBGene00001228", "Q18967", "WBGene00001229", "Q9XUP3", "WBGene00001233", "Q9XWI6", "WBGene00001225", "Q9TXU7", "WBGene00019162", "WBGene00019162", "A0A486WX07", "WBGene00002066", "Q20935", "WBGene00018997", "P27639", "WBGene00002083", "O61955", "WBGene00002061", "species_29438", "Q9BKU3", "WBGene00021351", "Q21230", "WBGene00010560", "Q95XR0", "WBGene00021466", "P51403", "WBGene00004471", "Q9NEN6", "WBGene00004475", "Q8WQA8", "WBGene00004489", "Q23312", "WBGene00004476", "O01869", "WBGene00004479", "P49197", "WBGene00004490", "P48156", "WBGene00004477", "Q20206", "WBGene00004480", "Q19877", "WBGene00004492", "Q20228", "WBGene00004478", "P49196", "WBGene00004481", "Q1XFY9", "WBGene00004493", "P46769", "WBGene00004469", "P51404", "WBGene00004482", "P52821", "WBGene00004494", "Q9TXP0", "WBGene00004496", "P48150", "WBGene00004483", "O45499", "WBGene00004495", "Q9N3X2", "WBGene00004473", "Q9XVP0", "WBGene00004484", "Q95Y04", "WBGene00004497", "Q22054", "WBGene00004485", "P90983", "WBGene00004498", "O01692", "WBGene00004486", "P48152", "WBGene00004472", "O18240", "WBGene00004487", "O18650", "WBGene00004488", "P48154", "WBGene00004470", "O17218", "WBGene00004491", "P49041", "WBGene00004474", "Q95QW0", "WBGene00015920", "O01974", "WBGene00001231", "Q94261", "WBGene00019543", "P34339", "WBGene00001209", "Q9XWP7", "WBGene00012738", "P30642", "WBGene00001227", "Q965S8", "WBGene00001232", "O02328", "WBGene00001226", "Q19706", "WBGene00001230", "O61820", "WBGene00001228", "Q18967", "WBGene00001229", "Q9XUP3", "WBGene00001233", "Q9XWI6", "WBGene00001225", "Q9TXU7", "WBGene00019162", "H2L0A8", "WBGene00019157" ] }, "reaction_10549921": { "compartment": "compartment_876", "id": "reaction_10549921", "reactome": "R-CEL-5138441", "name": "WNT5A-FZD4 recruits DVL2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10549898", "species_10515048" ], "products": [ "species_10549902" ], "modifiers": [], "additional_components": [ "Q9N532", "WBGene00003238", "G5EDV1", "WBGene00003006", "P34889", "WBGene00000858", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "Q9N532", "WBGene00003238", "G5EDV1", "WBGene00003006", "P34889", "WBGene00000858" ] }, "reaction_10549909": { "compartment": "compartment_876", "id": "reaction_10549909", "reactome": "R-CEL-5138432", "name": "DVL2 is phosphorylated by PKC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10549902", "species_113592" ], "products": [ "species_29370", "species_10549904" ], "modifiers": [ [ "species_10549906", "catalyst" ] ], "additional_components": [ "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "Q9N532", "WBGene00003238", "G5EDV1", "WBGene00003006", "P34889", "WBGene00000858", "Q9N532", "WBGene00003238", "G5EDV1", "WBGene00003006", "P34889", "WBGene00000858", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241" ] }, "reaction_10549900": { "compartment": "compartment_876", "id": "reaction_10549900", "reactome": "R-CEL-5099899", "name": "WNT5A binds FZD4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546954", "species_10548869" ], "products": [ "species_10549898" ], "modifiers": [], "additional_components": [ "WBGene00000858", "Q9N532", "WBGene00003238", "G5EDV1", "WBGene00003006", "Q9N532", "WBGene00003238", "G5EDV1", "WBGene00003006", "P34889", "WBGene00000858" ] }, "reaction_10549919": { "compartment": "compartment_876", "id": "reaction_10549919", "reactome": "R-CEL-5138433", "name": "p-DVL2 recruits AP-2 and beta-arrestin 2 to promote clathrin-mediated endocytosis", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10521727", "species_10549913", "species_10549904" ], "products": [ "species_10549917" ], "modifiers": [], "additional_components": [ "WBGene00000195", "P34574", "WBGene00011867", "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q9N532", "WBGene00003238", "G5EDV1", "WBGene00003006", "P34889", "WBGene00000858", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "P34574", "WBGene00011867", "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q9N532", "WBGene00003238", "G5EDV1", "WBGene00003006", "P34889", "WBGene00000858", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "P51485", "WBGene00000195" ] }, "reaction_10549967": { "compartment": "compartment_20592", "id": "reaction_10549967", "reactome": "R-CEL-5138459", "name": "WNT5A:FZD4 is endocytosed", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10549917" ], "products": [ "species_10521727", "species_10549965" ], "modifiers": [], "additional_components": [ "P34574", "WBGene00011867", "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q9N532", "WBGene00003238", "G5EDV1", "WBGene00003006", "P34889", "WBGene00000858", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "P51485", "WBGene00000195", "WBGene00000195", "Q9N4F3", "WBGene00000160", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q22601", "WBGene00000161", "P34574", "WBGene00011867", "P34889", "WBGene00000858", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "G5EDV1", "WBGene00003006", "Q9N532", "WBGene00003238" ] }, "reaction_10548310": { "compartment": "compartment_876", "id": "reaction_10548310", "reactome": "R-CEL-3858482", "name": "DVL is recruited to the receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10548306", "species_10548304" ], "products": [ "species_10548308" ], "modifiers": [], "additional_components": [ "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "A0A0K3AWM6", "T23D8.1b", "Q27886", "WBGene00003029", "Q10459", "WBGene00003395", "A0A0K3AWM6", "T23D8.1b", "Q27886", "WBGene00003029", "Q10459", "WBGene00003395", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241" ] }, "reaction_10548294": { "compartment": "compartment_70101", "id": "reaction_10548294", "reactome": "R-CEL-3858475", "name": "ppDVL recruits RAC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10548290", "species_10548288" ], "products": [ "species_10548292" ], "modifiers": [], "additional_components": [ "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "Q03206", "ced-10", "species_29438", "Q03206", "ced-10", "species_29438", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241" ] }, "reaction_10549994": { "compartment": "compartment_20592", "id": "reaction_10549994", "reactome": "R-CEL-5140747", "name": "FZD2, FZD5 and ROR2 are internalized in a WNT5A and clathrin-dependent manner", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10549978" ], "products": [ "species_10549992" ], "modifiers": [ [ "species_10549913", "catalyst" ] ], "additional_components": [ "G5EGK5", "WBGene00000289", "A0A0K3AWM6", "T23D8.1b", "G5ECQ2", "WBGene00000478", "P34889", "WBGene00000858", "P34889", "WBGene00000858", "G5ECQ2", "WBGene00000478", "G5EGK5", "WBGene00000289", "A0A0K3AWM6", "T23D8.1b", "P34574", "WBGene00011867", "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "P35603", "WBGene00001082", "Q19123", "WBGene00000157" ] }, "reaction_10549980": { "compartment": "compartment_876", "id": "reaction_10549980", "reactome": "R-CEL-5140741", "name": "WNT5A binds FZD and ROR receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546954", "species_10549976" ], "products": [ "species_10549978" ], "modifiers": [], "additional_components": [ "WBGene00000858", "G5EGK5", "WBGene00000289", "A0A0K3AWM6", "T23D8.1b", "G5ECQ2", "WBGene00000478", "G5EGK5", "WBGene00000289", "A0A0K3AWM6", "T23D8.1b", "G5ECQ2", "WBGene00000478", "P34889", "WBGene00000858" ] }, "reaction_10549896": { "compartment": "compartment_876", "id": "reaction_10549896", "reactome": "R-CEL-5099886", "name": "WNT5A binding to FZD promotes PRICKLE1 degradation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546954", "species_10549892" ], "products": [ "species_10549894" ], "modifiers": [], "additional_components": [ "WBGene00000858", "G5ECQ2", "WBGene00000478", "G5ECQ2", "WBGene00000478", "P34889", "WBGene00000858" ] }, "reaction_10549370": { "compartment": "compartment_70101", "id": "reaction_10549370", "reactome": "R-CEL-4608855", "name": "PRICKLE1 is degraded by the proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10549368" ], "products": [], "modifiers": [ [ "species_10502572", "catalyst" ] ], "additional_components": [ "H2KYA1", "WBGene00022727", "H2KZA3", "WBGene00004112", "Q17525", "WBGene00015217", "P91477", "WBGene00003950", "Q95PZ7", "WBGene00013435", "Q18115", "WBGene00004459", "O62102", "WBGene00003948", "O17071", "WBGene00004504", "Q10920", "WBGene00016623", "P34286", "WBGene00003952", "Q9XTT9", "WBGene00004506", "Q23449", "WBGene00004468", "Q95005", "WBGene00003925", "P46502", "WBGene00004503", "O61792", "WBGene00004464", "O17586", "WBGene00003922", "O76371", "WBGene00004505", "Q20585", "WBGene00004463", "Q95008", "WBGene00003926", "Q18787", "WBGene00004501", "Q20058", "WBGene00009445", "Q9N599", "WBGene00003924", "O16368", "WBGene00004502", "O61742", "WBGene00004466", "Q09583", "WBGene00003928", "Q966I8", "WBGene00003947", "Q04908", "WBGene00004460", "Q9XUV0", "WBGene00003951", "Q27488", "WBGene00003923", "Q9GZH5", "WBGene00004458", "O44156", "WBGene00003927", "Q22253", "WBGene00004465", "O76577", "WBGene00004467", "P90868", "WBGene00003953", "Q19324", "WBGene00004461", "Q17971", "WBGene00007588", "Q23237", "WBGene00003949", "Q20938", "WBGene00004462" ] }, "reaction_10567373": { "compartment": "compartment_876", "id": "reaction_10567373", "reactome": "R-CEL-8875661", "name": "GGA3 associates with activated MET receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10565510", "species_10565557", "species_10567330" ], "products": [ "species_10567371" ], "modifiers": [], "additional_components": [ "WBGene00000166", "Q9U2S4", "WBGene00000184", "species_29438", "G5EDJ4", "WBGene00004928", "Q9XVQ7", "WBGene00008711", "P29355", "WBGene00004774", "Q9NHC3", "WBGene00000416", "Q95XA9", "WBGene00021238", "G5EDJ4", "WBGene00004928", "Q9XVQ7", "WBGene00008711", "P29355", "WBGene00004774", "Q9NHC3", "WBGene00000416", "Q95XA9", "WBGene00021238", "Q9U2S4", "WBGene00000184", "species_29438", "Q23165", "WBGene00000166" ] }, "reaction_10515028": { "compartment": "compartment_876", "id": "reaction_10515028", "reactome": "R-CEL-201677", "name": "Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10515006", "species_113592" ], "products": [ "species_29370", "species_10515025" ], "modifiers": [ [ "species_10515006", "catalyst" ] ], "additional_components": [ "A0A0K3AWM6", "T23D8.1b", "G5EBV9", "WBGene00020481", "Q22179", "WBGene00003075", "Q7JP80", "WBGene00020481", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "Q9U2Q9", "WBGene00001746", "Q09595", "WBGene00010991", "Q93372", "WBGene00010991", "O62090", "WBGene00004202", "A0A0K3AWM6", "T23D8.1b", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "Q9U2Q9", "WBGene00001746", "Q09595", "WBGene00010991", "Q93372", "WBGene00010991", "O62090", "WBGene00004202", "G5EBV9", "WBGene00020481", "Q22179", "WBGene00003075", "Q7JP80", "WBGene00020481", "A0A0K3AWM6", "T23D8.1b", "G5EBV9", "WBGene00020481", "Q22179", "WBGene00003075", "Q7JP80", "WBGene00020481", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "Q9U2Q9", "WBGene00001746", "Q09595", "WBGene00010991", "Q93372", "WBGene00010991", "O62090", "WBGene00004202" ] }, "reaction_10535159": { "compartment": "compartment_70101", "id": "reaction_10535159", "reactome": "R-CEL-1504186", "name": "DVL recruits GSK3beta:AXIN1 to the receptor complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10514942", "species_10515004" ], "products": [ "species_10515006" ], "modifiers": [], "additional_components": [ "Q9U2Q9", "WBGene00001746", "Q09595", "WBGene00010991", "Q93372", "WBGene00010991", "O62090", "WBGene00004202", "A0A0K3AWM6", "T23D8.1b", "G5EBV9", "WBGene00020481", "Q22179", "WBGene00003075", "Q7JP80", "WBGene00020481", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "A0A0K3AWM6", "T23D8.1b", "G5EBV9", "WBGene00020481", "Q22179", "WBGene00003075", "Q7JP80", "WBGene00020481", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "Q9U2Q9", "WBGene00001746", "Q09595", "WBGene00010991", "Q93372", "WBGene00010991", "O62090", "WBGene00004202" ] }, "reaction_10551830": { "compartment": "compartment_876", "id": "reaction_10551830", "reactome": "R-CEL-5368596", "name": "WNT3A stimulates the caveolin-dependent internalization of FZD5:p-LRP6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10551808" ], "products": [ "species_10551828" ], "modifiers": [], "additional_components": [ "G5ECQ2", "WBGene00000478", "Q18879", "WBGene00000302", "Q94051", "WBGene00000301", "Q9U2Q9", "WBGene00001746", "Q09595", "WBGene00010991", "Q93372", "WBGene00010991", "O62090", "WBGene00004202", "G5EBV9", "WBGene00020481", "Q22179", "WBGene00003075", "Q7JP80", "WBGene00020481", "Q7JP80", "WBGene00020481", "G5EBV9", "WBGene00020481", "Q22179", "WBGene00003075", "Q18879", "WBGene00000302", "Q94051", "WBGene00000301", "G5ECQ2", "WBGene00000478", "Q9U2Q9", "WBGene00001746", "Q09595", "WBGene00010991", "Q93372", "WBGene00010991", "O62090", "WBGene00004202" ] }, "reaction_10507606": { "compartment": "compartment_7660", "id": "reaction_10507606", "reactome": "R-CEL-75949", "name": "RNA Polymerase II Promoter Opening: First Transition", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10507432" ], "products": [ "species_113550", "species_113582", "species_10507424" ], "modifiers": [ [ "species_10506316", "catalyst" ] ], "additional_components": [ "G5EG49", "WBGene00013998", "G5EG47", "WBGene00010054", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q95ZS0", "WBGene00006392", "Q9GZI6", "WBGene00006387", "G5EF68", "WBGene00006386", "O45784", "WBGene00006391", "P32085", "WBGene00006542", "O61707", "WBGene00006385", "Q9NEW8", "WBGene00006389", "Q9TYN3", "WBGene00006383", "Q18265", "WBGene00016173", "Q17957", "WBGene00006397", "E9P861", "WBGene00006384", "Q20361", "WBGene00006395", "G5EGM3", "WBGene00006382", "O44625", "WBGene00004136", "Q9NEX2", "WBGene00013736", "O16991", "WBGene00006648", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "G5EG49", "WBGene00013998", "G5EG47", "WBGene00010054", "O44625", "WBGene00004136", "Q9NEX2", "WBGene00013736", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q95ZS0", "WBGene00006392", "Q9GZI6", "WBGene00006387", "G5EF68", "WBGene00006386", "O45784", "WBGene00006391", "P32085", "WBGene00006542", "O61707", "WBGene00006385", "Q9NEW8", "WBGene00006389", "Q9TYN3", "WBGene00006383", "Q18265", "WBGene00016173", "Q17957", "WBGene00006397", "E9P861", "WBGene00006384", "Q20361", "WBGene00006395", "G5EGM3", "WBGene00006382", "O16991", "WBGene00006648", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529" ] }, "reaction_10507459": { "compartment": "compartment_7660", "id": "reaction_10507459", "reactome": "R-CEL-75873", "name": "Addition of Nucleotides 5 through 9 on the growing Transcript", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30595", "species_10507442" ], "products": [ "species_113541", "species_10506516", "species_10506433", "species_10507457", "species_10506528" ], "modifiers": [ [ "species_10504433", "catalyst" ] ], "additional_components": [ "species_110614", "species_29358", "species_29494", "species_29438", "G5EG49", "WBGene00013998", "G5EG47", "WBGene00010054", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "O44625", "WBGene00004136", "Q9NEX2", "WBGene00013736", "Q95ZS0", "WBGene00006392", "Q9GZI6", "WBGene00006387", "G5EF68", "WBGene00006386", "O45784", "WBGene00006391", "P32085", "WBGene00006542", "O61707", "WBGene00006385", "Q9NEW8", "WBGene00006389", "Q9TYN3", "WBGene00006383", "Q18265", "WBGene00016173", "Q17957", "WBGene00006397", "E9P861", "WBGene00006384", "Q20361", "WBGene00006395", "G5EGM3", "WBGene00006382", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q95ZS0", "WBGene00006392", "Q9GZI6", "WBGene00006387", "G5EF68", "WBGene00006386", "O45784", "WBGene00006391", "P32085", "WBGene00006542", "O61707", "WBGene00006385", "Q9NEW8", "WBGene00006389", "Q9TYN3", "WBGene00006383", "Q18265", "WBGene00016173", "Q17957", "WBGene00006397", "E9P861", "WBGene00006384", "Q20361", "WBGene00006395", "G5EGM3", "WBGene00006382", "O44625", "WBGene00004136", "Q9NEX2", "WBGene00013736", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "G5EG49", "WBGene00013998", "G5EG47", "WBGene00010054", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140" ] }, "reaction_10507444": { "compartment": "compartment_7660", "id": "reaction_10507444", "reactome": "R-CEL-75869", "name": "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30595", "species_10507394" ], "products": [ "species_10506438", "species_113541", "species_10507442" ], "modifiers": [ [ "species_10504433", "catalyst" ] ], "additional_components": [ "species_110614", "species_29358", "species_29494", "species_29438", "G5EG49", "WBGene00013998", "G5EG47", "WBGene00010054", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "O44625", "WBGene00004136", "Q9NEX2", "WBGene00013736", "Q95ZS0", "WBGene00006392", "Q9GZI6", "WBGene00006387", "G5EF68", "WBGene00006386", "O45784", "WBGene00006391", "P32085", "WBGene00006542", "O61707", "WBGene00006385", "Q9NEW8", "WBGene00006389", "Q9TYN3", "WBGene00006383", "Q18265", "WBGene00016173", "Q17957", "WBGene00006397", "E9P861", "WBGene00006384", "Q20361", "WBGene00006395", "G5EGM3", "WBGene00006382", "O16991", "WBGene00006648", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "WBGene00006648", "G5EG49", "WBGene00013998", "G5EG47", "WBGene00010054", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "O44625", "WBGene00004136", "Q9NEX2", "WBGene00013736", "Q95ZS0", "WBGene00006392", "Q9GZI6", "WBGene00006387", "G5EF68", "WBGene00006386", "O45784", "WBGene00006391", "P32085", "WBGene00006542", "O61707", "WBGene00006385", "Q9NEW8", "WBGene00006389", "Q9TYN3", "WBGene00006383", "Q18265", "WBGene00016173", "Q17957", "WBGene00006397", "E9P861", "WBGene00006384", "Q20361", "WBGene00006395", "G5EGM3", "WBGene00006382", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140" ] }, "reaction_10508100": { "compartment": "compartment_7660", "id": "reaction_10508100", "reactome": "R-CEL-76576", "name": "Addition of nucleotides 10 and 11 on the growing transcript: Third Transition", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30595", "species_10507457" ], "products": [ "species_113541", "species_10508098" ], "modifiers": [ [ "species_10504433", "catalyst" ] ], "additional_components": [ "species_110614", "species_29358", "species_29494", "species_29438", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140" ] }, "reaction_10507397": { "compartment": "compartment_7660", "id": "reaction_10507397", "reactome": "R-CEL-75850", "name": "Addition of the third nucleotide on the nascent transcript", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30595", "species_10506530" ], "products": [ "species_113541", "species_10507394" ], "modifiers": [ [ "species_10504433", "catalyst" ] ], "additional_components": [ "species_110614", "species_29358", "species_29494", "species_29438", "G5EG49", "WBGene00013998", "G5EG47", "WBGene00010054", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "O44625", "WBGene00004136", "Q9NEX2", "WBGene00013736", "Q95ZS0", "WBGene00006392", "Q9GZI6", "WBGene00006387", "G5EF68", "WBGene00006386", "O45784", "WBGene00006391", "P32085", "WBGene00006542", "O61707", "WBGene00006385", "Q9NEW8", "WBGene00006389", "Q9TYN3", "WBGene00006383", "Q18265", "WBGene00016173", "Q17957", "WBGene00006397", "E9P861", "WBGene00006384", "Q20361", "WBGene00006395", "G5EGM3", "WBGene00006382", "O16991", "WBGene00006648", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "G5EG49", "WBGene00013998", "G5EG47", "WBGene00010054", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "O44625", "WBGene00004136", "Q9NEX2", "WBGene00013736", "Q95ZS0", "WBGene00006392", "Q9GZI6", "WBGene00006387", "G5EF68", "WBGene00006386", "O45784", "WBGene00006391", "P32085", "WBGene00006542", "O61707", "WBGene00006385", "Q9NEW8", "WBGene00006389", "Q9TYN3", "WBGene00006383", "Q18265", "WBGene00016173", "Q17957", "WBGene00006397", "E9P861", "WBGene00006384", "Q20361", "WBGene00006395", "G5EGM3", "WBGene00006382", "O16991", "WBGene00006648", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140" ] }, "reaction_10572134": { "compartment": "compartment_7660", "id": "reaction_10572134", "reactome": "R-CEL-9613494", "name": "Unwinding of DNA for the Nascent Transcript: Second Transition", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10507394" ], "products": [ "species_164121", "species_113541", "species_10507394" ], "modifiers": [ [ "species_10506316", "catalyst" ] ], "additional_components": [ "G5EG49", "WBGene00013998", "G5EG47", "WBGene00010054", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "O44625", "WBGene00004136", "Q9NEX2", "WBGene00013736", "Q95ZS0", "WBGene00006392", "Q9GZI6", "WBGene00006387", "G5EF68", "WBGene00006386", "O45784", "WBGene00006391", "P32085", "WBGene00006542", "O61707", "WBGene00006385", "Q9NEW8", "WBGene00006389", "Q9TYN3", "WBGene00006383", "Q18265", "WBGene00016173", "Q17957", "WBGene00006397", "E9P861", "WBGene00006384", "Q20361", "WBGene00006395", "G5EGM3", "WBGene00006382", "O16991", "WBGene00006648", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "G5EG49", "WBGene00013998", "G5EG47", "WBGene00010054", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "O44625", "WBGene00004136", "Q9NEX2", "WBGene00013736", "Q95ZS0", "WBGene00006392", "Q9GZI6", "WBGene00006387", "G5EF68", "WBGene00006386", "O45784", "WBGene00006391", "P32085", "WBGene00006542", "O61707", "WBGene00006385", "Q9NEW8", "WBGene00006389", "Q9TYN3", "WBGene00006383", "Q18265", "WBGene00016173", "Q17957", "WBGene00006397", "E9P861", "WBGene00006384", "Q20361", "WBGene00006395", "G5EGM3", "WBGene00006382", "O16991", "WBGene00006648", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529" ] }, "reaction_10572136": { "compartment": "compartment_7660", "id": "reaction_10572136", "reactome": "R-CEL-9613497", "name": "Unwinding DNA for the nascent transcript", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30595", "species_10506530" ], "products": [ "species_113541", "species_10506530" ], "modifiers": [ [ "species_10506316", "catalyst" ] ], "additional_components": [ "species_110614", "species_29358", "species_29494", "species_29438", "G5EG49", "WBGene00013998", "G5EG47", "WBGene00010054", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "O44625", "WBGene00004136", "Q9NEX2", "WBGene00013736", "Q95ZS0", "WBGene00006392", "Q9GZI6", "WBGene00006387", "G5EF68", "WBGene00006386", "O45784", "WBGene00006391", "P32085", "WBGene00006542", "O61707", "WBGene00006385", "Q9NEW8", "WBGene00006389", "Q9TYN3", "WBGene00006383", "Q18265", "WBGene00016173", "Q17957", "WBGene00006397", "E9P861", "WBGene00006384", "Q20361", "WBGene00006395", "G5EGM3", "WBGene00006382", "O16991", "WBGene00006648", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "G5EG49", "WBGene00013998", "G5EG47", "WBGene00010054", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "O44625", "WBGene00004136", "Q9NEX2", "WBGene00013736", "Q95ZS0", "WBGene00006392", "Q9GZI6", "WBGene00006387", "G5EF68", "WBGene00006386", "O45784", "WBGene00006391", "P32085", "WBGene00006542", "O61707", "WBGene00006385", "Q9NEW8", "WBGene00006389", "Q9TYN3", "WBGene00006383", "Q18265", "WBGene00016173", "Q17957", "WBGene00006397", "E9P861", "WBGene00006384", "Q20361", "WBGene00006395", "G5EGM3", "WBGene00006382", "O16991", "WBGene00006648", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529" ] }, "reaction_10508830": { "compartment": "compartment_7660", "id": "reaction_10508830", "reactome": "R-CEL-111264", "name": "Addition of nucleotides between position +11 and +30", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30595", "species_10508098" ], "products": [ "species_10508135", "species_113541" ], "modifiers": [ [ "species_10504433", "catalyst" ] ], "additional_components": [ "species_110614", "species_29358", "species_29494", "species_29438", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140" ] }, "reaction_10547360": { "compartment": "compartment_70101", "id": "reaction_10547360", "reactome": "R-CEL-3322016", "name": "GBE1 catalyzes branch formation in polyGlc-GYG2 complexed with GYS2-a", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10547348" ], "products": [ "species_10547358" ], "modifiers": [ [ "species_10547328", "catalyst" ] ], "additional_components": [ "Q9U2D9", "WBGene00001793", "species_114632", "G5ECZ5", "WBGene00011684", "H2KYQ5", "WBGene00006863", "O45819", "WBGene00012020", "Q9U2D9", "WBGene00001793", "species_114632", "H2KYQ5", "WBGene00006863", "O45819", "WBGene00012020", "G5ECZ5", "WBGene00011684", "WBGene00011409" ] }, "reaction_10547331": { "compartment": "compartment_70101", "id": "reaction_10547331", "reactome": "R-CEL-3322005", "name": "GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-a", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10547303" ], "products": [ "species_10547323" ], "modifiers": [ [ "species_10547328", "catalyst" ] ], "additional_components": [ "Q9U2D9", "WBGene00001793", "species_114632", "H2KYQ5", "WBGene00006863", "Q9U2D9", "WBGene00001793", "species_114632", "H2KYQ5", "WBGene00006863", "WBGene00011409" ] }, "reaction_10547369": { "compartment": "compartment_70101", "id": "reaction_10547369", "reactome": "R-CEL-3322019", "name": "Autoglucosylation of GYG2 complexed with GYS2-b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10547364", "species_29410" ], "products": [ "species_10547366", "species_110096" ], "modifiers": [ [ "species_10547364", "catalyst" ] ], "additional_components": [ "Q9U2D9", "WBGene00001793", "species_114632", "G5ECZ5", "WBGene00011684", "H2KYQ5", "WBGene00006863", "O45819", "WBGene00012020", "G5ECZ5", "WBGene00011684", "H2KYQ5", "WBGene00006863", "O45819", "WBGene00012020", "Q9U2D9", "WBGene00001793", "species_114632", "Q9U2D9", "WBGene00001793", "species_114632", "G5ECZ5", "WBGene00011684", "H2KYQ5", "WBGene00006863", "O45819", "WBGene00012020" ] }, "reaction_10502858": { "compartment": "compartment_70101", "id": "reaction_10502858", "reactome": "R-CEL-70272", "name": "PGM:Mg2+ isomerise G6P to G1P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30537" ], "products": [ "species_29548" ], "modifiers": [ [ "species_10502855", "catalyst" ] ], "additional_components": [ "species_114632", "O45934", "WBGene00012803" ] }, "reaction_10547306": { "compartment": "compartment_70101", "id": "reaction_10547306", "reactome": "R-CEL-3322001", "name": "GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10547301", "species_29410" ], "products": [ "species_10547303", "species_110096" ], "modifiers": [ [ "species_10547301", "catalyst" ] ], "additional_components": [ "Q9U2D9", "WBGene00001793", "H2KYQ5", "WBGene00006863", "species_114632", "Q9U2D9", "WBGene00001793", "species_114632", "H2KYQ5", "WBGene00006863", "Q9U2D9", "WBGene00001793", "H2KYQ5", "WBGene00006863", "species_114632" ] }, "reaction_10547374": { "compartment": "compartment_70101", "id": "reaction_10547374", "reactome": "R-CEL-3322025", "name": "Autoglucosylation of GYG1 complexed with GYS1-a", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10547371", "species_29410" ], "products": [ "species_10547301", "species_110096" ], "modifiers": [ [ "species_10547371", "catalyst" ] ], "additional_components": [ "Q9U2D9", "WBGene00001793", "species_114632", "H2KYQ5", "WBGene00006863", "Q9U2D9", "WBGene00001793", "H2KYQ5", "WBGene00006863", "species_114632", "Q9U2D9", "WBGene00001793", "species_114632", "H2KYQ5", "WBGene00006863" ] }, "reaction_10547379": { "compartment": "compartment_70101", "id": "reaction_10547379", "reactome": "R-CEL-3322041", "name": "Phosphorylated GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10547315", "species_29410" ], "products": [ "species_110096", "species_10547376" ], "modifiers": [ [ "species_10547315", "catalyst" ], [ "species_30537", "catalyst" ] ], "additional_components": [ "H2KYQ5", "WBGene00006863", "species_114632", "Q9U2D9", "WBGene00001793", "species_114632", "H2KYQ5", "WBGene00006863", "Q9U2D9", "WBGene00001793", "H2KYQ5", "WBGene00006863", "species_114632", "Q9U2D9", "WBGene00001793" ] }, "reaction_10547318": { "compartment": "compartment_70101", "id": "reaction_10547318", "reactome": "R-CEL-3322003", "name": "Autoglucosylation of GYG1 complexed with GYS1-b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29410", "species_10547313" ], "products": [ "species_10547315", "species_110096" ], "modifiers": [ [ "species_10547313", "catalyst" ] ], "additional_components": [ "species_114632", "H2KYQ5", "WBGene00006863", "Q9U2D9", "WBGene00001793", "H2KYQ5", "WBGene00006863", "species_114632", "Q9U2D9", "WBGene00001793", "species_114632", "H2KYQ5", "WBGene00006863", "Q9U2D9", "WBGene00001793" ] }, "reaction_10547351": { "compartment": "compartment_70101", "id": "reaction_10547351", "reactome": "R-CEL-3322009", "name": "GYS2 catalyzes the polyglucosylation of oligoGlc-GYG2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10547346", "species_29410" ], "products": [ "species_10547348", "species_110096" ], "modifiers": [ [ "species_10547346", "catalyst" ] ], "additional_components": [ "G5ECZ5", "WBGene00011684", "H2KYQ5", "WBGene00006863", "O45819", "WBGene00012020", "Q9U2D9", "WBGene00001793", "species_114632", "Q9U2D9", "WBGene00001793", "species_114632", "G5ECZ5", "WBGene00011684", "H2KYQ5", "WBGene00006863", "O45819", "WBGene00012020", "G5ECZ5", "WBGene00011684", "H2KYQ5", "WBGene00006863", "O45819", "WBGene00012020", "Q9U2D9", "WBGene00001793", "species_114632" ] }, "reaction_10547383": { "compartment": "compartment_70101", "id": "reaction_10547383", "reactome": "R-CEL-3322057", "name": "GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10547376" ], "products": [ "species_10547381" ], "modifiers": [ [ "species_10547328", "catalyst" ] ], "additional_components": [ "species_114632", "H2KYQ5", "WBGene00006863", "Q9U2D9", "WBGene00001793", "species_114632", "H2KYQ5", "WBGene00006863", "Q9U2D9", "WBGene00001793", "WBGene00011409" ] }, "reaction_10572378": { "compartment": "compartment_70101", "id": "reaction_10572378", "reactome": "R-CEL-9638125", "name": "PGM1:Mg2+ isomerises G1P to G6P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29548" ], "products": [ "species_30537" ], "modifiers": [ [ "species_10572375", "catalyst" ] ], "additional_components": [ "Q21742", "WBGene00019890", "species_114632" ] }, "reaction_10547356": { "compartment": "compartment_70101", "id": "reaction_10547356", "reactome": "R-CEL-3322014", "name": "Autoglucosylation of GYG2 complexed with GYS2-a", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10547353", "species_29410" ], "products": [ "species_10547346", "species_110096" ], "modifiers": [ [ "species_10547353", "catalyst" ] ], "additional_components": [ "Q9U2D9", "WBGene00001793", "species_114632", "G5ECZ5", "WBGene00011684", "H2KYQ5", "WBGene00006863", "O45819", "WBGene00012020", "G5ECZ5", "WBGene00011684", "H2KYQ5", "WBGene00006863", "O45819", "WBGene00012020", "Q9U2D9", "WBGene00001793", "species_114632", "Q9U2D9", "WBGene00001793", "species_114632", "G5ECZ5", "WBGene00011684", "H2KYQ5", "WBGene00006863", "O45819", "WBGene00012020" ] }, "reaction_10569064": { "compartment": "compartment_70101", "id": "reaction_10569064", "reactome": "R-CEL-8951850", "name": "TSPO:BZRAP1 transports CHOL from outer mitochondrial membrane to inner mitochondrial membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8951853" ], "products": [ "species_193156" ], "modifiers": [ [ "species_10569061", "catalyst" ] ], "additional_components": [ "C7FZU5", "WBGene00077771", "Q9N415", "WBGene00006513" ] }, "reaction_10513657": { "compartment": "compartment_70101", "id": "reaction_10513657", "reactome": "R-CEL-196060", "name": "Reduction of isocaproaldehyde to 4-methylpentan-1-ol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_196095", "species_70106", "species_29364" ], "products": [ "species_29366", "species_196066" ], "modifiers": [ [ "species_10513654", "catalyst" ] ], "additional_components": [ "WBGene00016985" ] }, "reaction_10556977": { "compartment": "compartment_70101", "id": "reaction_10556977", "reactome": "R-CEL-5693390", "name": "HSD17B11 dehydrogenates EST17b to E1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193132", "species_29366" ], "products": [ "species_70106", "species_193066", "species_29364" ], "modifiers": [ [ "species_10556974", "catalyst" ] ], "additional_components": [ "A5JYX5", "WBGene00000967", "O18030", "WBGene00000968", "Q19843", "WBGene00000992", "Q22392", "WBGene00000982" ] }, "reaction_10557699": { "compartment": "compartment_5460", "id": "reaction_10557699", "reactome": "R-CEL-5696822", "name": "AKR1B15 reduces EST17b to E1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113563", "species_5696835" ], "products": [ "species_113529", "species_5696848", "species_113600" ], "modifiers": [ [ "species_10557696", "catalyst" ] ], "additional_components": [ "P91020", "WBGene00016985", "Q18903", "WBGene00016985", "Q23320", "WBGene00016985" ] }, "reaction_10513367": { "compartment": "compartment_70101", "id": "reaction_10513367", "reactome": "R-CEL-193143", "name": "CYP19A1 hydroxylates TEST to EST17b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29368", "species_29364", "species_193057" ], "products": [ "species_193132", "species_29356", "species_29366", "species_29460" ], "modifiers": [ [ "species_10513352", "catalyst" ] ], "additional_components": [ "Q09660", "WBGene00000375", "Q9N525", "WBGene00021412", "Q9N574", "WBGene00021200", "Q9XVA6", "WBGene00008499", "G5EC97", "WBGene00011830", "G5EGT6", "WBGene00010354", "O17851", "WBGene00009226", "O45219", "WBGene00007140" ] }, "reaction_10565899": { "compartment": "compartment_70101", "id": "reaction_10565899", "reactome": "R-CEL-8862137", "name": "HSD17B2 oxidises estradiol (E2) to estrone (E1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_176619", "species_29366" ], "products": [ "species_70106", "species_193066", "species_29364" ], "modifiers": [ [ "species_10565896", "catalyst" ] ], "additional_components": [ "O01758", "WBGene00000966", "O16881", "WBGene00000979", "Q20012", "WBGene00000983", "Q20840", "WBGene00018885" ] }, "reaction_10533200": { "compartment": "compartment_984", "id": "reaction_10533200", "reactome": "R-CEL-1449687", "name": "Corticosteroids bind to CBG in blood", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1449707", "species_10533196" ], "products": [ "species_10533198" ], "modifiers": [], "additional_components": [ "CHEBI:27584", "CHEBI:17026", "species_193977", "CHEBI:16973", "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "A9Z1L1", "WBGene00005648", "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "A9Z1L1", "WBGene00005648", "CHEBI:27584", "CHEBI:17026", "species_193977", "CHEBI:16973" ] }, "reaction_10513471": { "compartment": "compartment_17957", "id": "reaction_10513471", "reactome": "R-CEL-194023", "name": "HSD11B2,HSD11B1 dimer oxidise CORT to COR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193977", "species_29366" ], "products": [ "species_70106", "species_29364", "species_194035" ], "modifiers": [ [ "species_10513468", "catalyst" ] ], "additional_components": [ "O16881", "WBGene00000979", "Q20012", "WBGene00000983", "Q20840", "WBGene00018885", "O01758", "WBGene00000966" ] }, "reaction_10573281": { "compartment": "compartment_70101", "id": "reaction_10573281", "reactome": "R-CEL-9705713", "name": "SRD5A2 dehydrogenates TEST to DHTEST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_193057" ], "products": [ "species_469662", "species_29366" ], "modifiers": [ [ "species_10573278", "catalyst" ] ], "additional_components": [ "Q19605", "WBGene00014241", "Q20344", "WBGene00009635", "Q23431", "WBGene00014241" ] }, "reaction_10513365": { "compartment": "compartment_70101", "id": "reaction_10513365", "reactome": "R-CEL-193064", "name": "HSD17B3-like proteins reducde ANDST to TEST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_193079", "species_29364" ], "products": [ "species_29366", "species_193057" ], "modifiers": [ [ "species_10513360", "catalyst" ] ], "additional_components": [ "WBGene00000969" ] }, "reaction_10573284": { "compartment": "compartment_70101", "id": "reaction_10573284", "reactome": "R-CEL-9705714", "name": "SRD5A3 dehydrogenates TEST to DHTEST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_193057" ], "products": [ "species_469662", "species_29366" ], "modifiers": [ [ "species_10549201", "catalyst" ] ], "additional_components": [ "WBGene00007102" ] }, "reaction_10526217": { "compartment": "compartment_70101", "id": "reaction_10526217", "reactome": "R-CEL-469659", "name": "SRD5A1 dehydrogenates TEST to DHTEST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_193057" ], "products": [ "species_469662", "species_29366" ], "modifiers": [ [ "species_10526214", "catalyst" ] ], "additional_components": [ "WBGene00009635" ] }, "reaction_10567315": { "compartment": "compartment_70101", "id": "reaction_10567315", "reactome": "R-CEL-8875451", "name": "MET phosphorylates CBL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10567312" ], "products": [ "species_29370", "species_10567233" ], "modifiers": [ [ "species_10567312", "catalyst" ] ], "additional_components": [ "Q9XVQ7", "WBGene00008711", "P29355", "WBGene00004774", "Q19019", "WBGene00004829", "Q9XVQ7", "WBGene00008711", "P29355", "WBGene00004774", "Q19019", "WBGene00004829", "Q9XVQ7", "WBGene00008711", "P29355", "WBGene00004774", "Q19019", "WBGene00004829" ] }, "reaction_10567305": { "compartment": "compartment_876", "id": "reaction_10567305", "reactome": "R-CEL-8875374", "name": "MET binds LRIG1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10521542", "species_10567301" ], "products": [ "species_10567303" ], "modifiers": [], "additional_components": [ "WBGene00008711", "WBGene00020649", "Q965M2", "WBGene00020649", "Q9XVQ7", "WBGene00008711" ] }, "reaction_10567321": { "compartment": "compartment_70101", "id": "reaction_10567321", "reactome": "R-CEL-8875490", "name": "EPS15 and HGS bind ubiquitinated MET", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10512223", "species_10567317" ], "products": [ "species_10567319" ], "modifiers": [], "additional_components": [ "Q9BIF4", "WBGene00001224", "Q17796", "WBGene00004101", "O01498", "WBGene00004109", "Q9BIF4", "WBGene00001224", "Q17796", "WBGene00004101", "O01498", "WBGene00004109" ] }, "reaction_10567245": { "compartment": "compartment_70101", "id": "reaction_10567245", "reactome": "R-CEL-8875183", "name": "CBL monoubiquitinates activated MET", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502375", "species_10567233" ], "products": [ "species_10567242" ], "modifiers": [ [ "species_10567233", "catalyst" ] ], "additional_components": [ "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "Q9XVQ7", "WBGene00008711", "P29355", "WBGene00004774", "Q19019", "WBGene00004829", "Q9XVQ7", "WBGene00008711", "P29355", "WBGene00004774", "Q19019", "WBGene00004829", "Q9XVQ7", "WBGene00008711", "P29355", "WBGene00004774", "Q19019", "WBGene00004829" ] }, "reaction_10508741": { "compartment": "compartment_7660", "id": "reaction_10508741", "reactome": "R-CEL-110308", "name": "REV1 inserts dCMP opposite to AP sites in DNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508730", "species_30185" ], "products": [ "species_10508738" ], "modifiers": [ [ "species_10508730", "catalyst" ] ], "additional_components": [ "Q95Y97", "WBGene00019767", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "O02115", "WBGene00003955", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "Q09615", "WBGene00014066", "Q95Y97", "WBGene00019767", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "O02115", "WBGene00003955", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "Q09615", "WBGene00014066", "Q95Y97", "WBGene00019767", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "O02115", "WBGene00003955", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "Q09615", "WBGene00014066" ] }, "reaction_10508732": { "compartment": "compartment_7660", "id": "reaction_10508732", "reactome": "R-CEL-110307", "name": "REV1 binds AP-dsDNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508715", "species_10508728" ], "products": [ "species_10508730" ], "modifiers": [], "additional_components": [ "WBGene00014066", "Q95Y97", "WBGene00019767", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "O02115", "WBGene00003955", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "Q95Y97", "WBGene00019767", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "O02115", "WBGene00003955", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "Q09615", "WBGene00014066" ] }, "reaction_10567136": { "compartment": "compartment_70101", "id": "reaction_10567136", "reactome": "R-CEL-8873850", "name": "STARD5 binds DCA, LCA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_176655", "species_10567132", "species_5357505" ], "products": [ "species_10567134" ], "modifiers": [], "additional_components": [ "WBGene00010505", "species_5357505", "Q21130", "WBGene00010505", "species_176655" ] }, "reaction_10510001": { "compartment": "compartment_70101", "id": "reaction_10510001", "reactome": "R-CEL-159425", "name": "Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_76194", "species_194096" ], "products": [ "species_111294", "species_29356", "species_194073", "species_76577" ], "modifiers": [ [ "species_10509998", "catalyst" ] ], "additional_components": [ "species_193451", "CHEBI:16755", "species_192356", "species_193472", "Q18916", "WBGene00017012", "Q19878", "WBGene00009218" ] }, "reaction_10513491": { "compartment": "compartment_876", "id": "reaction_10513491", "reactome": "R-CEL-194187", "name": "SLC10A2 transports bile salts and acids and Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10513481", "species_192483", "species_74113" ], "products": [ "species_10513483", "species_83910" ], "modifiers": [ [ "species_10513488", "catalyst" ] ], "additional_components": [ "O01812", "WBGene00002258", "O01814", "WBGene00002257", "O02323", "WBGene00002259", "O02324", "WBGene00002260", "CHEBI:17687", "CHEBI:28865", "CHEBI:16755", "CHEBI:36274", "species_193451", "CHEBI:9407", "O01812", "WBGene00002258", "O01814", "WBGene00002257", "O02323", "WBGene00002259", "O02324", "WBGene00002260", "species_193451", "CHEBI:17687", "CHEBI:36274", "CHEBI:16525", "CHEBI:16755", "CHEBI:28865", "WBGene00044650" ] }, "reaction_10551492": { "compartment": "compartment_7660", "id": "reaction_10551492", "reactome": "R-CEL-5340195", "name": "NR1H4 binds DCA, CDCA, LCHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5340249", "species_10519476" ], "products": [ "species_10551490" ], "modifiers": [], "additional_components": [ "species_176655", "CHEBI:16755", "species_5357505", "WBGene00006790", "G5ECR9", "WBGene00006790", "species_176655", "CHEBI:16755", "species_5357505" ] }, "reaction_10513382": { "compartment": "compartment_876", "id": "reaction_10513382", "reactome": "R-CEL-193362", "name": "ABCB11 transports bile salts from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_193416", "species_113592" ], "products": [ "species_29372", "species_29370", "species_193479" ], "modifiers": [ [ "species_10513379", "catalyst" ] ], "additional_components": [ "CHEBI:17687", "CHEBI:36274", "CHEBI:16525", "CHEBI:28865", "CHEBI:17687", "CHEBI:28865", "CHEBI:36274", "CHEBI:9407", "P34712", "WBGene00003995", "G5EG58", "WBGene00004003" ] }, "reaction_10510026": { "compartment": "compartment_70101", "id": "reaction_10510026", "reactome": "R-CEL-159431", "name": "Cytosolic chenodeoxycholoyl-CoA or choloyl-CoA are conjugated with glycine or taurine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_194073", "species_194069" ], "products": [ "species_193416", "species_76194" ], "modifiers": [ [ "species_10510023", "catalyst" ] ], "additional_components": [ "species_192356", "species_193472", "species_159549", "CHEBI:15891", "CHEBI:17687", "CHEBI:36274", "CHEBI:16525", "CHEBI:28865", "O45003", "WBGene00020989", "Q9GYN3", "WBGene00020989", "B3WFZ3", "WBGene00020989", "O01862", "WBGene00020989" ] }, "reaction_10513424": { "compartment": "compartment_17951", "id": "reaction_10513424", "reactome": "R-CEL-193736", "name": "Isomerization of 3,7,24THCA-CoA to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193732" ], "products": [ "species_193732" ], "modifiers": [ [ "species_10513241", "catalyst" ] ], "additional_components": [ "WBGene00016034" ] }, "reaction_10513426": { "compartment": "compartment_70101", "id": "reaction_10513426", "reactome": "R-CEL-193743", "name": "3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_76194", "species_193778" ], "products": [ "species_111294", "species_29356", "species_193739", "species_76577" ], "modifiers": [ [ "species_10513398", "catalyst" ] ], "additional_components": [ "Q18916", "WBGene00017012", "Q19878", "WBGene00009218" ] }, "reaction_10513428": { "compartment": "compartment_70101", "id": "reaction_10513428", "reactome": "R-CEL-193746", "name": "4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193724", "species_70106", "species_29364" ], "products": [ "species_29366", "species_193760" ], "modifiers": [ [ "species_10513222", "catalyst" ] ], "additional_components": [ "Q23320", "WBGene00016985", "P91020", "WBGene00016985", "Q18903", "WBGene00016985" ] }, "reaction_10513430": { "compartment": "compartment_70101", "id": "reaction_10513430", "reactome": "R-CEL-193755", "name": "4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_193745" ], "products": [ "species_193707", "species_29366" ], "modifiers": [ [ "species_10513222", "catalyst" ] ], "additional_components": [ "Q23320", "WBGene00016985", "P91020", "WBGene00016985", "Q18903", "WBGene00016985" ] }, "reaction_10513432": { "compartment": "compartment_70101", "id": "reaction_10513432", "reactome": "R-CEL-193758", "name": "5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_193760" ], "products": [ "species_29366", "species_213285" ], "modifiers": [ [ "species_10513233", "catalyst" ] ], "additional_components": [ "P91020", "WBGene00016985", "Q18903", "WBGene00016985", "Q23320", "WBGene00016985" ] }, "reaction_10513434": { "compartment": "compartment_17951", "id": "reaction_10513434", "reactome": "R-CEL-193763", "name": "Isomerization of 25(R) TetraHCA-CoA to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193793" ], "products": [ "species_193422" ], "modifiers": [ [ "species_10513241", "catalyst" ] ], "additional_components": [ "WBGene00016034" ] }, "reaction_10513436": { "compartment": "compartment_70101", "id": "reaction_10513436", "reactome": "R-CEL-193766", "name": "TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_76194", "species_193762" ], "products": [ "species_111294", "species_193741", "species_29356", "species_76577" ], "modifiers": [ [ "species_10509998", "catalyst" ] ], "additional_components": [ "Q18916", "WBGene00017012", "Q19878", "WBGene00009218" ] }, "reaction_10513420": { "compartment": "compartment_70101", "id": "reaction_10513420", "reactome": "R-CEL-193711", "name": "3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_76194", "species_193778" ], "products": [ "species_111294", "species_29356", "species_193739", "species_76577" ], "modifiers": [ [ "species_10509998", "catalyst" ] ], "additional_components": [ "Q18916", "WBGene00017012", "Q19878", "WBGene00009218" ] }, "reaction_10513438": { "compartment": "compartment_70101", "id": "reaction_10513438", "reactome": "R-CEL-193781", "name": "5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_193707", "species_29364" ], "products": [ "species_29366", "species_193728" ], "modifiers": [ [ "species_10513233", "catalyst" ] ], "additional_components": [ "P91020", "WBGene00016985", "Q18903", "WBGene00016985", "Q23320", "WBGene00016985" ] }, "reaction_10513422": { "compartment": "compartment_70101", "id": "reaction_10513422", "reactome": "R-CEL-193727", "name": "TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_76194", "species_193762" ], "products": [ "species_111294", "species_193741", "species_29356", "species_76577" ], "modifiers": [ [ "species_10513398", "catalyst" ] ], "additional_components": [ "Q18916", "WBGene00017012", "Q19878", "WBGene00009218" ] }, "reaction_10513440": { "compartment": "compartment_70101", "id": "reaction_10513440", "reactome": "R-CEL-193800", "name": "5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_193829", "species_29364" ], "products": [ "species_29366", "species_193843" ], "modifiers": [ [ "species_10513233", "catalyst" ] ], "additional_components": [ "P91020", "WBGene00016985", "Q18903", "WBGene00016985", "Q23320", "WBGene00016985" ] }, "reaction_10513442": { "compartment": "compartment_70101", "id": "reaction_10513442", "reactome": "R-CEL-193821", "name": "4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_9617026" ], "products": [ "species_193829", "species_29366" ], "modifiers": [ [ "species_10513222", "catalyst" ] ], "additional_components": [ "Q23320", "WBGene00016985", "P91020", "WBGene00016985", "Q18903", "WBGene00016985" ] }, "reaction_10513444": { "compartment": "compartment_70101", "id": "reaction_10513444", "reactome": "R-CEL-193824", "name": "4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_193835", "species_29364" ], "products": [ "species_29366", "species_193830" ], "modifiers": [ [ "species_10513222", "catalyst" ] ], "additional_components": [ "Q23320", "WBGene00016985", "P91020", "WBGene00016985", "Q18903", "WBGene00016985" ] }, "reaction_10513446": { "compartment": "compartment_70101", "id": "reaction_10513446", "reactome": "R-CEL-193841", "name": "5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_193830" ], "products": [ "species_29366", "species_193842" ], "modifiers": [ [ "species_10513233", "catalyst" ] ], "additional_components": [ "P91020", "WBGene00016985", "Q18903", "WBGene00016985", "Q23320", "WBGene00016985" ] }, "reaction_10513205": { "compartment": "compartment_70101", "id": "reaction_10513205", "reactome": "R-CEL-191983", "name": "Cholesterol is hydroxylated to 25-hydroxycholesterol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_176478", "species_70106", "species_29368", "species_29364" ], "products": [ "species_29356", "species_192148", "species_29366" ], "modifiers": [ [ "species_10513202", "catalyst" ] ], "additional_components": [ "Q20027", "WBGene00018036", "species_113531" ] }, "reaction_10566516": { "compartment": "compartment_70101", "id": "reaction_10566516", "reactome": "R-CEL-8868402", "name": "OSBP exchanges 25OH-CHOL with PI4P from ER membrane to Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8868399", "species_1806217" ], "products": [ "species_8868393", "species_1806234" ], "modifiers": [ [ "species_10566513", "catalyst" ] ], "additional_components": [ "WBGene00012930" ] }, "reaction_10566397": { "compartment": "compartment_70101", "id": "reaction_10566397", "reactome": "R-CEL-8867667", "name": "OSBPs transport 25OH-CHOL from ER membrane to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8868399" ], "products": [ "species_8868400" ], "modifiers": [ [ "species_10566394", "catalyst" ] ], "additional_components": [ "Q93485", "WBGene00008832", "O01686", "WBGene00016331" ] }, "reaction_10513248": { "compartment": "compartment_70101", "id": "reaction_10513248", "reactome": "R-CEL-192137", "name": "THCA is conjugated with Coenzyme A (SLC27A5 BACS)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_192013", "species_113592", "species_76194" ], "products": [ "species_111294", "species_192096", "species_76577" ], "modifiers": [ [ "species_10509998", "catalyst" ] ], "additional_components": [ "Q18916", "WBGene00017012", "Q19878", "WBGene00009218" ] }, "reaction_10513250": { "compartment": "compartment_70101", "id": "reaction_10513250", "reactome": "R-CEL-192160", "name": "5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191980", "species_70106", "species_29364" ], "products": [ "species_192030", "species_29366" ], "modifiers": [ [ "species_10513233", "catalyst" ] ], "additional_components": [ "P91020", "WBGene00016985", "Q18903", "WBGene00016985", "Q23320", "WBGene00016985" ] }, "reaction_10513410": { "compartment": "compartment_17951", "id": "reaction_10513410", "reactome": "R-CEL-193455", "name": "(24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193422", "species_192307" ], "products": [ "species_193465", "species_192305", "species_192339" ], "modifiers": [ [ "species_10513270", "catalyst" ] ], "additional_components": [ "Q19058", "WBGene00017123" ] }, "reaction_10513412": { "compartment": "compartment_17951", "id": "reaction_10513412", "reactome": "R-CEL-193491", "name": "Chenodeoxycholoyl CoA reacts with glycine or taurine to form glycochenodeoxycholate or taurochenodeoxycholate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193463", "species_193472" ], "products": [ "species_193453", "species_193514" ], "modifiers": [ [ "species_10513260", "catalyst" ] ], "additional_components": [ "species_159549", "CHEBI:15891", "CHEBI:36274", "CHEBI:16525", "B3WFZ3", "WBGene00020989", "O01862", "WBGene00020989", "O45003", "WBGene00020989", "Q9GYN3", "WBGene00020989" ] }, "reaction_10513414": { "compartment": "compartment_17951", "id": "reaction_10513414", "reactome": "R-CEL-193508", "name": "(24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193732", "species_192307" ], "products": [ "species_193465", "species_193403", "species_192305" ], "modifiers": [ [ "species_10513270", "catalyst" ] ], "additional_components": [ "Q19058", "WBGene00017123" ] }, "reaction_10513384": { "compartment": "compartment_17951", "id": "reaction_10513384", "reactome": "R-CEL-193369", "name": "25(S) DHCA-CoA is dehydrogenated to 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113535", "species_193442" ], "products": [ "species_113575", "species_193459" ], "modifiers": [ [ "species_10513307", "catalyst" ] ], "additional_components": [ "species_113596", "P34355", "WBGene00008167", "O62138", "WBGene00008566", "Q93839", "WBGene00010336", "O62139", "WBGene00008567", "O62140", "WBGene00008564", "O62137", "WBGene00008565" ] }, "reaction_10513416": { "compartment": "compartment_17951", "id": "reaction_10513416", "reactome": "R-CEL-193535", "name": "25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA is hydrated to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_141343", "species_193459" ], "products": [ "species_193732" ], "modifiers": [ [ "species_10513270", "catalyst" ] ], "additional_components": [ "Q19058", "WBGene00017123" ] }, "reaction_10513225": { "compartment": "compartment_70101", "id": "reaction_10513225", "reactome": "R-CEL-192033", "name": "4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_192136", "species_29364" ], "products": [ "species_191980", "species_29366" ], "modifiers": [ [ "species_10513222", "catalyst" ] ], "additional_components": [ "Q23320", "WBGene00016985", "P91020", "WBGene00016985", "Q18903", "WBGene00016985" ] }, "reaction_10513263": { "compartment": "compartment_17951", "id": "reaction_10513263", "reactome": "R-CEL-192312", "name": "Choloyl CoA reacts with glycine or taurine to form glycocholate or taurocholate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_192356", "species_193463" ], "products": [ "species_193404", "species_193514" ], "modifiers": [ [ "species_10513260", "catalyst" ] ], "additional_components": [ "species_159549", "CHEBI:15891", "CHEBI:17687", "CHEBI:28865", "B3WFZ3", "WBGene00020989", "O01862", "WBGene00020989", "O45003", "WBGene00020989", "Q9GYN3", "WBGene00020989" ] }, "reaction_10513392": { "compartment": "compartment_17951", "id": "reaction_10513392", "reactome": "R-CEL-193385", "name": "Hydrolysis of choloyl-CoA to cholate and CoASH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_141343", "species_192356" ], "products": [ "species_193451", "species_193514" ], "modifiers": [ [ "species_10513389", "catalyst" ] ], "additional_components": [ "WBGene00015887" ] }, "reaction_10513236": { "compartment": "compartment_70101", "id": "reaction_10513236", "reactome": "R-CEL-192036", "name": "5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_192064" ], "products": [ "species_29366", "species_192087" ], "modifiers": [ [ "species_10513233", "catalyst" ] ], "additional_components": [ "P91020", "WBGene00016985", "Q18903", "WBGene00016985", "Q23320", "WBGene00016985" ] }, "reaction_10513401": { "compartment": "compartment_70101", "id": "reaction_10513401", "reactome": "R-CEL-193401", "name": "THCA is conjugated with Coenzyme A (SLC27A2 VLCS)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_192013", "species_113592", "species_76194" ], "products": [ "species_111294", "species_192096", "species_76577" ], "modifiers": [ [ "species_10513398", "catalyst" ] ], "additional_components": [ "Q18916", "WBGene00017012", "Q19878", "WBGene00009218" ] }, "reaction_10513273": { "compartment": "compartment_17951", "id": "reaction_10513273", "reactome": "R-CEL-192331", "name": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) is hydrated to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_141343", "species_192342" ], "products": [ "species_193422" ], "modifiers": [ [ "species_10513270", "catalyst" ] ], "additional_components": [ "Q19058", "WBGene00017123" ] }, "reaction_10513403": { "compartment": "compartment_70101", "id": "reaction_10513403", "reactome": "R-CEL-193407", "name": "DHCA is conjugated with Coenzyme A (SLC27A5 BACS)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_193505", "species_76194" ], "products": [ "species_111294", "species_193457", "species_76577" ], "modifiers": [ [ "species_10509998", "catalyst" ] ], "additional_components": [ "Q18916", "WBGene00017012", "Q19878", "WBGene00009218" ] }, "reaction_10513244": { "compartment": "compartment_17951", "id": "reaction_10513244", "reactome": "R-CEL-192056", "name": "Isomerization of 25(R) THCA-CoA to 25(S) THCA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_192308" ], "products": [ "species_192316" ], "modifiers": [ [ "species_10513241", "catalyst" ] ], "additional_components": [ "WBGene00016034" ] }, "reaction_10513405": { "compartment": "compartment_70101", "id": "reaction_10513405", "reactome": "R-CEL-193424", "name": "DHCA is conjugated with Coenzyme A (SLC27A2 VLCS)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_76194", "species_193505" ], "products": [ "species_111294", "species_193457", "species_76577" ], "modifiers": [ [ "species_10513398", "catalyst" ] ], "additional_components": [ "Q18916", "WBGene00017012", "Q19878", "WBGene00009218" ] }, "reaction_10513246": { "compartment": "compartment_70101", "id": "reaction_10513246", "reactome": "R-CEL-192067", "name": "4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_192195" ], "products": [ "species_29366", "species_192064" ], "modifiers": [ [ "species_10513222", "catalyst" ] ], "additional_components": [ "Q23320", "WBGene00016985", "P91020", "WBGene00016985", "Q18903", "WBGene00016985" ] }, "reaction_10513310": { "compartment": "compartment_17951", "id": "reaction_10513310", "reactome": "R-CEL-192335", "name": "25(S) THCA-CoA is dehydrogenated to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113535", "species_192316" ], "products": [ "species_113575", "species_192342" ], "modifiers": [ [ "species_10513307", "catalyst" ] ], "additional_components": [ "species_113596", "P34355", "WBGene00008167", "O62138", "WBGene00008566", "Q93839", "WBGene00010336", "O62139", "WBGene00008567", "O62140", "WBGene00008564", "O62137", "WBGene00008565" ] }, "reaction_10513407": { "compartment": "compartment_17951", "id": "reaction_10513407", "reactome": "R-CEL-193452", "name": "Isomerization of 25(R) DHCA-CoA to 25(S) DHCA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193429" ], "products": [ "species_193442" ], "modifiers": [ [ "species_10513241", "catalyst" ] ], "additional_components": [ "WBGene00016034" ] }, "reaction_10516904": { "compartment": "compartment_13231", "id": "reaction_10516904", "reactome": "R-CEL-211219", "name": "Translocation of caspase-3 to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509422" ], "products": [ "species_10516902" ], "modifiers": [], "additional_components": [ "P42573", "WBGene00000417", "P42573", "WBGene00000417" ] }, "reaction_10517886": { "compartment": "compartment_7660", "id": "reaction_10517886", "reactome": "R-CEL-266204", "name": "Association of HMGB1/HMGB2 with chromatin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10517882", "species_29428" ], "products": [ "species_10517884" ], "modifiers": [], "additional_components": [ "Q09390", "WBGene00001972", "G5EFV4", "WBGene00001971", "Q09390", "WBGene00001972", "G5EFV4", "WBGene00001971" ] }, "reaction_10551440": { "compartment": "compartment_7660", "id": "reaction_10551440", "reactome": "R-CEL-5334854", "name": "RAR:RXR binds SUMO-CRABP2:atRA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10551436", "species_10551432" ], "products": [ "species_10551438" ], "modifiers": [], "additional_components": [ "species_5334816", "O01812", "WBGene00002258", "Q9U2R6", "WBGene00003681", "Q20765", "WBGene00003606", "P41830", "WBGene00004786", "Q9XUK7", "WBGene00003675", "Q10902", "WBGene00003601", "Q9U2R6", "WBGene00003681", "Q20765", "WBGene00003606", "P41830", "WBGene00004786", "Q9XUK7", "WBGene00003675", "Q10902", "WBGene00003601", "species_5334816", "O01812", "WBGene00002258" ] }, "reaction_10553123": { "compartment": "compartment_70101", "id": "reaction_10553123", "reactome": "R-CEL-5622129", "name": "FABP5 binds atRA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10551364", "species_5334816" ], "products": [ "species_10553121" ], "modifiers": [], "additional_components": [ "WBGene00021486", "species_5334816", "Q965W1", "WBGene00021486" ] }, "reaction_10552339": { "compartment": "compartment_7660", "id": "reaction_10552339", "reactome": "R-CEL-5422942", "name": "RXRA:PPARD binds FABP5:atRA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10552335", "species_10514501" ], "products": [ "species_10552337" ], "modifiers": [], "additional_components": [ "species_5334816", "Q965W1", "WBGene00021486", "Q9XUK7", "WBGene00003675", "P41830", "WBGene00004786", "Q10902", "WBGene00003601", "Q20765", "WBGene00003606", "Q9U2R6", "WBGene00003681", "Q9XUK7", "WBGene00003675", "P41830", "WBGene00004786", "Q10902", "WBGene00003601", "Q20765", "WBGene00003606", "Q9U2R6", "WBGene00003681", "species_5334816", "Q965W1", "WBGene00021486" ] }, "reaction_10552705": { "compartment": "compartment_70101", "id": "reaction_10552705", "reactome": "R-CEL-5615668", "name": "AKR1C3 reduces atRAL to atROL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_975622", "species_29364" ], "products": [ "species_29366", "species_975599" ], "modifiers": [ [ "species_10513233", "catalyst" ] ], "additional_components": [ "P91020", "WBGene00016985", "Q18903", "WBGene00016985", "Q23320", "WBGene00016985" ] }, "reaction_10551747": { "compartment": "compartment_70101", "id": "reaction_10551747", "reactome": "R-CEL-5362518", "name": "RDH10,16,DHRS9,RDHE2 oxidise atROL to atRAL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_975599", "species_29360" ], "products": [ "species_70106", "species_975622", "species_73473" ], "modifiers": [ [ "species_10551744", "catalyst" ] ], "additional_components": [ "A5JYX5", "WBGene00000967", "O18030", "WBGene00000968", "Q19843", "WBGene00000992", "Q22392", "WBGene00000982", "O16881", "WBGene00000979", "O01758", "WBGene00000966", "Q20012", "WBGene00000983", "Q20840", "WBGene00018885" ] }, "reaction_10553251": { "compartment": "compartment_70616", "id": "reaction_10553251", "reactome": "R-CEL-5623643", "name": "RDH13 reduces atRAL to atROL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5623644", "species_5623648", "species_163953" ], "products": [ "species_5623650", "species_5623649" ], "modifiers": [ [ "species_10553248", "catalyst" ] ], "additional_components": [ "WBGene00000985" ] }, "reaction_10551781": { "compartment": "compartment_70101", "id": "reaction_10551781", "reactome": "R-CEL-5362721", "name": "RDH5,RDH11 oxidise 11cROL to 11cRAL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30927", "species_29360" ], "products": [ "species_70106", "species_32737", "species_73473" ], "modifiers": [ [ "species_10551778", "catalyst" ] ], "additional_components": [ "Q20840", "WBGene00018885", "O01758", "WBGene00000966", "O16881", "WBGene00000979", "Q20012", "WBGene00000983" ] }, "reaction_10553125": { "compartment": "compartment_70101", "id": "reaction_10553125", "reactome": "R-CEL-5622134", "name": "CRABP1 binds atRA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5334816", "species_10551761" ], "products": [ "species_10551763" ], "modifiers": [], "additional_components": [ "O01812", "WBGene00002258", "O01814", "WBGene00002257", "O02323", "WBGene00002259", "O02324", "WBGene00002260", "O01812", "WBGene00002258", "O01814", "WBGene00002257", "O02323", "WBGene00002259", "O02324", "WBGene00002260", "species_5334816" ] }, "reaction_10551862": { "compartment": "compartment_70101", "id": "reaction_10551862", "reactome": "R-CEL-5419165", "name": "RDH11,14,DHRS3,DRHS4 reduce atRAL to atROL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_975622", "species_29364" ], "products": [ "species_29366", "species_975599" ], "modifiers": [ [ "species_10551859", "catalyst" ] ], "additional_components": [ "P91013", "WBGene00000965", "Q1XFZ3", "WBGene00000980", "A5JYX5", "WBGene00000967", "O18030", "WBGene00000968", "Q19843", "WBGene00000992", "Q22392", "WBGene00000982", "G5EGA6", "WBGene00010063" ] }, "reaction_10551768": { "compartment": "compartment_70101", "id": "reaction_10551768", "reactome": "R-CEL-5362564", "name": "ADH1A,1C,4 oxidise atROL to atRAL in vitro", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_975599", "species_29360" ], "products": [ "species_70106", "species_975622", "species_73473" ], "modifiers": [ [ "species_10551765", "catalyst" ] ], "additional_components": [ "species_216785", "Q17335", "WBGene00019240" ] }, "reaction_10557581": { "compartment": "compartment_70101", "id": "reaction_10557581", "reactome": "R-CEL-5696101", "name": "ALDH8A1 oxidises 9cRAL to 9cRA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_5362565", "species_29360" ], "products": [ "species_70106", "species_5362520", "species_73473" ], "modifiers": [ [ "species_10557578", "catalyst" ] ], "additional_components": [ "WBGene00000116" ] }, "reaction_10554022": { "compartment": "compartment_70101", "id": "reaction_10554022", "reactome": "R-CEL-5633256", "name": "FABP5:atRA translocates from cytosol to nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10553121" ], "products": [ "species_10552335" ], "modifiers": [], "additional_components": [ "species_5334816", "Q965W1", "WBGene00021486", "species_5334816", "Q965W1", "WBGene00021486" ] }, "reaction_10554024": { "compartment": "compartment_7660", "id": "reaction_10554024", "reactome": "R-CEL-5634100", "name": "FABP5 dissociates from RXRA:PPARD:atRA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10552337" ], "products": [ "species_10552333", "species_10514503" ], "modifiers": [], "additional_components": [ "Q9XUK7", "WBGene00003675", "P41830", "WBGene00004786", "Q10902", "WBGene00003601", "Q20765", "WBGene00003606", "Q9U2R6", "WBGene00003681", "species_5334816", "Q965W1", "WBGene00021486", "WBGene00021486", "Q9XUK7", "WBGene00003675", "P41830", "WBGene00004786", "Q10902", "WBGene00003601", "Q20765", "WBGene00003606", "Q9U2R6", "WBGene00003681", "species_5334816" ] }, "reaction_10514505": { "compartment": "compartment_70101", "id": "reaction_10514505", "reactome": "R-CEL-200406", "name": "CPT1A,B transfers PALM to CAR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_549207", "species_200993" ], "products": [ "species_201034", "species_76194" ], "modifiers": [ [ "species_10514471", "catalyst" ], [ "species_10514503", "catalyst" ], [ "species_29508", "inhibitor" ] ], "additional_components": [ "Q9N3N3", "WBGene00021703", "O16992", "WBGene00021002", "Q9U2F2", "WBGene00012907", "O44619", "WBGene00019644", "Q23066", "WBGene00020911", "G5EG54", "WBGene00008629", "Q9XUK7", "WBGene00003675", "P41830", "WBGene00004786", "Q10902", "WBGene00003601", "Q20765", "WBGene00003606", "Q9U2R6", "WBGene00003681", "species_5334816" ] }, "reaction_10554028": { "compartment": "compartment_7660", "id": "reaction_10554028", "reactome": "R-CEL-5634103", "name": "SUMO-CRABP2 dissociates from atRA:RAR:RXR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10551438" ], "products": [ "species_10551434", "species_10554026" ], "modifiers": [], "additional_components": [ "Q9U2R6", "WBGene00003681", "Q20765", "WBGene00003606", "P41830", "WBGene00004786", "Q9XUK7", "WBGene00003675", "Q10902", "WBGene00003601", "species_5334816", "O01812", "WBGene00002258", "WBGene00002258", "species_5334816", "Q9U2R6", "WBGene00003681", "Q20765", "WBGene00003606", "P41830", "WBGene00004786", "Q9XUK7", "WBGene00003675", "Q10902", "WBGene00003601" ] }, "reaction_10551391": { "compartment": "compartment_70101", "id": "reaction_10551391", "reactome": "R-CEL-5334827", "name": "SUMO-CRABP2 binds atRA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10551387", "species_5334816" ], "products": [ "species_10551389" ], "modifiers": [], "additional_components": [ "WBGene00002258", "species_5334816", "O01812", "WBGene00002258" ] }, "reaction_10554030": { "compartment": "compartment_70101", "id": "reaction_10554030", "reactome": "R-CEL-5634104", "name": "SUMO-CRABP2:atRA translocates from cytosol to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10551389" ], "products": [ "species_10551436" ], "modifiers": [], "additional_components": [ "species_5334816", "O01812", "WBGene00002258", "species_5334816", "O01812", "WBGene00002258" ] }, "reaction_10570912": { "compartment": "compartment_7660", "id": "reaction_10570912", "reactome": "R-CEL-9012319", "name": "p-TEFb phosphorylates serine 2 in RNA polymerase II CTD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10570907" ], "products": [ "species_113582", "species_10570909" ], "modifiers": [ [ "species_10570907", "catalyst" ] ], "additional_components": [ "Q9TVL3", "WBGene00000410", "P34424", "WBGene00000508", "P34425", "WBGene00000507", "species_1254400", "P16356", "WBGene00000123", "Q19826", "WBGene00017830", "Q9XVH6", "WBGene00012187", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q9U3I0", "WBGene00009078", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q10578", "WBGene00016140", "Q17684", "WBGene00007355", "O02092", "WBGene00018391", "Q9GR61", "WBGene00021347", "Q9N3C9", "WBGene00021845", "Q93338", "WBGene00007971", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q9TVL3", "WBGene00000410", "P34424", "WBGene00000508", "P34425", "WBGene00000507", "species_1254400", "Q9TVL3", "WBGene00000410", "P34424", "WBGene00000508", "P34425", "WBGene00000507", "species_1254400", "P16356", "WBGene00000123", "Q19826", "WBGene00017830", "Q9XVH6", "WBGene00012187", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q9U3I0", "WBGene00009078", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q10578", "WBGene00016140", "Q17684", "WBGene00007355", "O02092", "WBGene00018391", "Q9GR61", "WBGene00021347", "Q9N3C9", "WBGene00021845", "Q93338", "WBGene00007971" ] }, "reaction_10570805": { "compartment": "compartment_7660", "id": "reaction_10570805", "reactome": "R-CEL-9009533", "name": "TBP and TFIIA bind TATA box on ESR1:estrogen bound TFF1 gene promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10506254", "species_10506433", "species_10570801" ], "products": [ "species_10570803" ], "modifiers": [], "additional_components": [ "WBGene00006542", "O44625", "WBGene00004136", "Q9NEX2", "WBGene00013736", "Q9XUW5", "WBGene00010260", "CHEBI:142773", "species_5696848", "species_176619", "CHEBI:27974", "G5EGN3", "WBGene00001253", "P28515", "WBGene00001249", "Q9XUW7", "WBGene00001311", "G5EF25", "WBGene00003181", "G5EF71", "WBGene00003180", "U4PMB4", "WBGene00001186", "Q21187", "WBGene00001441", "Q17381", "WBGene00004013", "Q9XUW5", "WBGene00010260", "CHEBI:142773", "species_5696848", "species_176619", "CHEBI:27974", "G5EGN3", "WBGene00001253", "P28515", "WBGene00001249", "Q9XUW7", "WBGene00001311", "G5EF25", "WBGene00003181", "G5EF71", "WBGene00003180", "U4PMB4", "WBGene00001186", "Q21187", "WBGene00001441", "Q17381", "WBGene00004013", "O44625", "WBGene00004136", "Q9NEX2", "WBGene00013736", "P32085", "WBGene00006542" ] }, "reaction_10570772": { "compartment": "compartment_7660", "id": "reaction_10570772", "reactome": "R-CEL-9009065", "name": "FOXA1 and GATA3 bind to CCND1 promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10570727", "species_10570739", "species_10570768" ], "products": [ "species_10532119", "species_10570725", "species_10570770" ], "modifiers": [], "additional_components": [ "P45972", "WBGene00011639", "G5ECH0", "WBGene00001836", "P62784", "WBGene00001875", "Q10453", "WBGene00001945", "K7ZUH9", "WBGene00001914", "Q21187", "WBGene00001441", "Q17381", "WBGene00004013", "G5EGN3", "WBGene00001253", "P28515", "WBGene00001249", "Q9XUW7", "WBGene00001311", "G5EF25", "WBGene00003181", "G5EF71", "WBGene00003180", "U4PMB4", "WBGene00001186", "WBGene00001836", "WBGene00011639", "G5EGN3", "WBGene00001253", "P28515", "WBGene00001249", "Q9XUW7", "WBGene00001311", "G5EF25", "WBGene00003181", "G5EF71", "WBGene00003180", "U4PMB4", "WBGene00001186", "Q21187", "WBGene00001441", "Q17381", "WBGene00004013", "P62784", "WBGene00001875", "Q10453", "WBGene00001945", "K7ZUH9", "WBGene00001914" ] }, "reaction_10571524": { "compartment": "compartment_7660", "id": "reaction_10571524", "reactome": "R-CEL-9023860", "name": "Histone acetyltransferases are recruited to the TFF1 gene", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10571512", "species_10571520" ], "products": [ "species_10571522" ], "modifiers": [], "additional_components": [ "Q9TYU5", "WBGene00007029", "P34545", "WBGene00000366", "Q9N3S7", "WBGene00021636", "Q9XUW5", "WBGene00010260", "CHEBI:142773", "species_5696848", "species_176619", "CHEBI:27974", "G5EGN3", "WBGene00001253", "P28515", "WBGene00001249", "Q9XUW7", "WBGene00001311", "G5EF25", "WBGene00003181", "G5EF71", "WBGene00003180", "U4PMB4", "WBGene00001186", "Q21187", "WBGene00001441", "Q17381", "WBGene00004013", "O44625", "WBGene00004136", "Q9NEX2", "WBGene00013736", "P32085", "WBGene00006542", "Q9U2X0", "WBGene00013766", "Q9XUW5", "WBGene00010260", "CHEBI:142773", "species_5696848", "species_176619", "CHEBI:27974", "G5EGN3", "WBGene00001253", "P28515", "WBGene00001249", "Q9XUW7", "WBGene00001311", "G5EF25", "WBGene00003181", "G5EF71", "WBGene00003180", "U4PMB4", "WBGene00001186", "Q21187", "WBGene00001441", "Q17381", "WBGene00004013", "O44625", "WBGene00004136", "Q9NEX2", "WBGene00013736", "P32085", "WBGene00006542", "Q9U2X0", "WBGene00013766", "Q9TYU5", "WBGene00007029", "P34545", "WBGene00000366", "Q9N3S7", "WBGene00021636" ] }, "reaction_10571526": { "compartment": "compartment_7660", "id": "reaction_10571526", "reactome": "R-CEL-9023861", "name": "PRMT1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546564", "species_10570803" ], "products": [ "species_10571518" ], "modifiers": [], "additional_components": [ "WBGene00013766", "Q9XUW5", "WBGene00010260", "CHEBI:142773", "species_5696848", "species_176619", "CHEBI:27974", "G5EGN3", "WBGene00001253", "P28515", "WBGene00001249", "Q9XUW7", "WBGene00001311", "G5EF25", "WBGene00003181", "G5EF71", "WBGene00003180", "U4PMB4", "WBGene00001186", "Q21187", "WBGene00001441", "Q17381", "WBGene00004013", "O44625", "WBGene00004136", "Q9NEX2", "WBGene00013736", "P32085", "WBGene00006542", "Q9XUW5", "WBGene00010260", "CHEBI:142773", "species_5696848", "species_176619", "CHEBI:27974", "G5EGN3", "WBGene00001253", "P28515", "WBGene00001249", "Q9XUW7", "WBGene00001311", "G5EF25", "WBGene00003181", "G5EF71", "WBGene00003180", "U4PMB4", "WBGene00001186", "Q21187", "WBGene00001441", "Q17381", "WBGene00004013", "O44625", "WBGene00004136", "Q9NEX2", "WBGene00013736", "P32085", "WBGene00006542", "Q9U2X0", "WBGene00013766" ] }, "reaction_10568500": { "compartment": "compartment_7660", "id": "reaction_10568500", "reactome": "R-CEL-8939204", "name": "ESTG binds ESR1:chaperone complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10568488", "species_1254400" ], "products": [ "species_10568490" ], "modifiers": [], "additional_components": [ "Q09637", "WBGene00000885", "Q18688", "WBGene00000915", "species_29358", "Q23280", "WBGene00022599", "species_1254400", "Q09637", "WBGene00000885", "Q18688", "WBGene00000915", "species_29358", "Q23280", "WBGene00022599" ] }, "reaction_10573334": { "compartment": "compartment_7660", "id": "reaction_10573334", "reactome": "R-CEL-9709547", "name": "ESTG binds ESR2:chaperone complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10568494", "species_1254400" ], "products": [ "species_10568496" ], "modifiers": [], "additional_components": [ "Q09637", "WBGene00000885", "Q18688", "WBGene00000915", "species_29358", "Q23280", "WBGene00022599", "species_1254400", "Q09637", "WBGene00000885", "Q18688", "WBGene00000915", "species_29358", "Q23280", "WBGene00022599" ] }, "reaction_10515169": { "compartment": "compartment_70101", "id": "reaction_10515169", "reactome": "R-CEL-202127", "name": "eNOS synthesizes NO", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29468", "species_29368", "species_29364" ], "products": [ "species_202124", "species_29366", "species_29968" ], "modifiers": [ [ "species_10515166", "catalyst" ], [ "species_5693375", "inhibitor" ] ], "additional_components": [ "Q9XTG7", "WBGene00000103", "G4S4W1", "WBGene00016980", "Q17941", "WBGene00000102", "species_74016", "Q11083", "WBGene00020378", "P04630", "WBGene00000285", "G5EF37", "WBGene00003934", "A0A2C9C3L3", "WBGene00020378", "Q18136", "WBGene00006861", "Q09665", "WBGene00006583", "O02159", "WBGene00020378", "G5EDZ8", "WBGene00000288", "Q94288", "WBGene00000287", "Q09980", "WBGene00017394", "O16305", "WBGene00000552", "G5EEG0", "WBGene00000286", "Q18688", "WBGene00000915", "species_71185", "species_216785", "species_73524", "species_113596", "species_29870" ] }, "reaction_10572255": { "compartment": "compartment_7660", "id": "reaction_10572255", "reactome": "R-CEL-9624526", "name": "AKT phosphorylates FOXO3 downstream of ESR1 and EGFR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10514276" ], "products": [ "species_113582", "species_10514290" ], "modifiers": [ [ "species_10514266", "catalyst" ] ], "additional_components": [ "WBGene00000912", "WBGene00000912", "G4S4W1", "WBGene00016980", "Q17941", "WBGene00000102", "Q9XTG7", "WBGene00000103" ] }, "reaction_10572334": { "compartment": "compartment_7660", "id": "reaction_10572334", "reactome": "R-CEL-9632873", "name": "p-S10 CDKN1B translocates to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10572330" ], "products": [ "species_10572332" ], "modifiers": [ [ "species_10514056", "catalyst" ], [ "species_10511186", "catalyst" ] ], "additional_components": [ "WBGene00000517", "WBGene00000517", "P39745", "WBGene00003401", "WBGene00002078" ] }, "reaction_10572317": { "compartment": "compartment_70101", "id": "reaction_10572317", "reactome": "R-CEL-9632412", "name": "PTK2 is recruited to methylated ESR1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10572313", "species_10572310" ], "products": [ "species_10572315" ], "modifiers": [], "additional_components": [ "WBGene00002213", "A0A486WY88", "WBGene00010631", "species_1254400", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "G5EDP9", "WBGene00000001", "Q94125", "WBGene00000090", "A0A486WY88", "WBGene00010631", "species_1254400", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "G5EDP9", "WBGene00000001", "Q94125", "WBGene00000090", "Q95YD4", "WBGene00002213" ] }, "reaction_10572284": { "compartment": "compartment_876", "id": "reaction_10572284", "reactome": "R-CEL-9625814", "name": "SPHK1 phosphorylates sphingosine in response to E2 stimulation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1606609" ], "products": [ "species_5218688" ], "modifiers": [ [ "species_10520872", "catalyst" ] ], "additional_components": [ "WBGene00007918" ] }, "reaction_10572339": { "compartment": "compartment_876", "id": "reaction_10572339", "reactome": "R-CEL-9632906", "name": "PRKCZ recruits RAS in response to estrogen stimulation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10512175", "species_10572324" ], "products": [ "species_10572337" ], "modifiers": [], "additional_components": [ "species_29420", "P22981", "WBGene00002335", "Q9UA62", "WBGene00021022", "species_179838", "Q19266", "WBGene00004034", "Q9UA62", "WBGene00021022", "species_179838", "Q19266", "WBGene00004034", "species_29420", "P22981", "WBGene00002335" ] }, "reaction_10572327": { "compartment": "compartment_876", "id": "reaction_10572327", "reactome": "R-CEL-9632858", "name": "PRKCZ autophosphorylates downstream of estrogen stimulation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10572319", "species_113592" ], "products": [ "species_29370", "species_10572324" ], "modifiers": [ [ "species_10572319", "catalyst" ] ], "additional_components": [ "Q9UA62", "WBGene00021022", "species_179838", "Q19266", "WBGene00004034", "Q9UA62", "WBGene00021022", "species_179838", "Q19266", "WBGene00004034", "Q9UA62", "WBGene00021022", "species_179838", "Q19266", "WBGene00004034" ] }, "reaction_10572343": { "compartment": "compartment_7660", "id": "reaction_10572343", "reactome": "R-CEL-9632910", "name": "ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10542080" ], "products": [ "species_10514056" ], "modifiers": [ [ "species_10572341", "catalyst" ] ], "additional_components": [ "P39745", "WBGene00003401", "P39745", "WBGene00003401", "Q9UA62", "WBGene00021022", "species_179838", "Q19266", "WBGene00004034", "species_29438", "P22981", "WBGene00002335" ] }, "reaction_10572346": { "compartment": "compartment_876", "id": "reaction_10572346", "reactome": "R-CEL-9632918", "name": "PRKCZ stimulates RAS nucleotide exchange in response to estrogen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10572337" ], "products": [ "species_10572341" ], "modifiers": [], "additional_components": [ "Q9UA62", "WBGene00021022", "species_179838", "Q19266", "WBGene00004034", "species_29420", "P22981", "WBGene00002335", "Q9UA62", "WBGene00021022", "species_179838", "Q19266", "WBGene00004034", "species_29438", "P22981", "WBGene00002335" ] }, "reaction_10571584": { "compartment": "compartment_7660", "id": "reaction_10571584", "reactome": "R-CEL-9029566", "name": "Co-repressor complex dissociates from the transcription unit of the UGT1A3 gene ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10571574" ], "products": [ "species_10571582", "species_10517933" ], "modifiers": [], "additional_components": [ "G5ECR9", "WBGene00006790", "Q9U2R6", "WBGene00003681", "CHEBI:34310", "CHEBI:67237", "CHEBI:76591", "CHEBI:41633", "P34333", "WBGene00001565", "G5ECR9", "WBGene00006790", "Q9U2R6", "WBGene00003681", "CHEBI:34310", "CHEBI:67237", "CHEBI:76591", "CHEBI:41633", "WBGene00001565" ] }, "reaction_10571576": { "compartment": "compartment_7660", "id": "reaction_10571576", "reactome": "R-CEL-9029517", "name": "Oxysterol binds to the UGT1A3 gene:NR1H2,3:RXR:NCOR complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9024383", "species_10571572" ], "products": [ "species_10571574" ], "modifiers": [], "additional_components": [ "CHEBI:34310", "CHEBI:67237", "CHEBI:76591", "CHEBI:41633", "G5ECR9", "WBGene00006790", "Q9U2R6", "WBGene00003681", "P34333", "WBGene00001565", "G5ECR9", "WBGene00006790", "Q9U2R6", "WBGene00003681", "CHEBI:34310", "CHEBI:67237", "CHEBI:76591", "CHEBI:41633", "P34333", "WBGene00001565" ] }, "reaction_10537280": { "compartment": "compartment_20699", "id": "reaction_10537280", "reactome": "R-CEL-1676133", "name": "PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806217" ], "products": [ "species_29372", "species_1524146" ], "modifiers": [ [ "species_10537269", "catalyst" ] ], "additional_components": [ "WBGene00009264" ] }, "reaction_10537217": { "compartment": "compartment_20699", "id": "reaction_10537217", "reactome": "R-CEL-1675961", "name": "PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1524146" ], "products": [ "species_29370", "species_1806159" ], "modifiers": [ [ "species_10537193", "catalyst" ] ], "additional_components": [ "Q9TXI7", "WBGene00006932", "species_266099", "Q23669", "WBGene00014151", "G5EDY0", "WBGene00009552", "species_74016", "species_114632" ] }, "reaction_10537185": { "compartment": "compartment_20699", "id": "reaction_10537185", "reactome": "R-CEL-1675928", "name": "PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A/G at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1806217" ], "products": [ "species_1806230", "species_29370" ], "modifiers": [ [ "species_10537182", "catalyst" ] ], "additional_components": [ "G5EDY0", "WBGene00009552", "species_74016", "species_114632" ] }, "reaction_10537298": { "compartment": "compartment_20699", "id": "reaction_10537298", "reactome": "R-CEL-1676152", "name": "PI4KB binds to ARF1/3:GTP at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10537169", "species_10537296" ], "products": [ "species_10537171" ], "modifiers": [], "additional_components": [ "G5EFK4", "WBGene00000183", "species_29438", "Q10943", "WBGene00000182", "WBGene00018076", "G5EFK4", "WBGene00000183", "species_29438", "Q10943", "WBGene00000182", "Q20077", "WBGene00018076" ] }, "reaction_10537141": { "compartment": "compartment_20699", "id": "reaction_10537141", "reactome": "R-CEL-1675824", "name": "PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806165", "species_29356" ], "products": [ "species_29372", "species_1806217" ], "modifiers": [ [ "species_10537138", "catalyst" ] ], "additional_components": [ "WBGene00007620" ] }, "reaction_10537174": { "compartment": "compartment_20699", "id": "reaction_10537174", "reactome": "R-CEL-1675883", "name": "PI is phosphorylated to PI4P by PI4KB at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1524146" ], "products": [ "species_29370", "species_1806217" ], "modifiers": [ [ "species_10537171", "catalyst" ] ], "additional_components": [ "G5EFK4", "WBGene00000183", "species_29438", "Q10943", "WBGene00000182", "Q20077", "WBGene00018076" ] }, "reaction_10537272": { "compartment": "compartment_20699", "id": "reaction_10537272", "reactome": "R-CEL-1676114", "name": "PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1806159" ], "products": [ "species_29372", "species_1524146" ], "modifiers": [ [ "species_10537269", "catalyst" ] ], "additional_components": [ "WBGene00009264" ] }, "reaction_10537322": { "compartment": "compartment_20699", "id": "reaction_10537322", "reactome": "R-CEL-1676185", "name": "PI is phosphorylated to PI4P by PI4KA/2A/2B at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1524146" ], "products": [ "species_29370", "species_1806217" ], "modifiers": [ [ "species_10537319", "catalyst" ] ], "additional_components": [ "O45318", "WBGene00022501", "Q23083", "WBGene00022501", "Q9XW63", "WBGene00013557" ] }, "reaction_10502079": { "compartment": "compartment_7660", "id": "reaction_10502079", "reactome": "R-CEL-68611", "name": "Orc1 associates with Orc4:Orc5:Orc3:Orc2:origin complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502075", "species_10502070" ], "products": [ "species_10502077" ], "modifiers": [], "additional_components": [ "WBGene00012650", "Q9XX16", "WBGene00012651", "Q21037", "WBGene00003882", "Q23249", "WBGene00013857", "Q9XX16", "WBGene00012651", "Q21037", "WBGene00003882", "Q23249", "WBGene00013857", "Q9XX17", "WBGene00012650" ] }, "reaction_10548052": { "compartment": "compartment_70101", "id": "reaction_10548052", "reactome": "R-CEL-3772435", "name": "WNT signaling stimulates CSNK1-dependent phosphorylation of DVL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10515075" ], "products": [ "species_29370", "species_10515002" ], "modifiers": [ [ "species_10548049", "catalyst" ] ], "additional_components": [ "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "WBGene00002203" ] }, "reaction_10548055": { "compartment": "compartment_70101", "id": "reaction_10548055", "reactome": "R-CEL-3772436", "name": "DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_392417" ], "products": [ "species_29370", "species_179856" ], "modifiers": [ [ "species_10548042", "catalyst" ] ], "additional_components": [ "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "O01759", "WBGene00004087" ] }, "reaction_10515100": { "compartment": "compartment_70101", "id": "reaction_10515100", "reactome": "R-CEL-201717", "name": "CSNK2-mediated phosphorylation of DVL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10515052", "species_113592" ], "products": [ "species_29370", "species_10515075" ], "modifiers": [ [ "species_10515097", "catalyst" ] ], "additional_components": [ "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "P18334", "WBGene00002191", "P28548", "WBGene00002196" ] }, "reaction_10548044": { "compartment": "compartment_70101", "id": "reaction_10548044", "reactome": "R-CEL-3772434", "name": "Phosphorylated DVL recruits PIP5K1B to the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10537053", "species_10515002" ], "products": [ "species_10548042" ], "modifiers": [], "additional_components": [ "WBGene00004087", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "O01759", "WBGene00004087" ] }, "reaction_10573013": { "compartment": "compartment_70101", "id": "reaction_10573013", "reactome": "R-CEL-9667965", "name": "ANKLE2 binds PP2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546138", "species_10529273" ], "products": [ "species_10573011" ], "modifiers": [], "additional_components": [ "WBGene00021945", "Q09543", "WBGene00003901", "G5EDR3", "WBGene00006352", "G5EGK8", "WBGene00002363", "Q09543", "WBGene00003901", "G5EDR3", "WBGene00006352", "G5EGK8", "WBGene00002363", "H2KZB2", "WBGene00021945" ] }, "reaction_10546149": { "compartment": "compartment_70101", "id": "reaction_10546149", "reactome": "R-CEL-2995389", "name": "ANKLE2 binds VRK1,(VRK2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546143", "species_10546138" ], "products": [ "species_10546147" ], "modifiers": [], "additional_components": [ "WBGene00017895", "WBGene00021945", "H2KZB2", "WBGene00021945", "Q19848", "WBGene00017895" ] }, "reaction_10572275": { "compartment": "compartment_1598585", "id": "reaction_10572275", "reactome": "R-CEL-9624845", "name": "RCC1 stimulates GDP to GTP exchange on RAN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10558002" ], "products": [ "species_29420", "species_10572267" ], "modifiers": [ [ "species_10572272", "catalyst" ] ], "additional_components": [ "O17915", "WBGene00004302", "species_29420", "O17915", "WBGene00004302", "species_29438", "WBGene00004304" ] }, "reaction_10572213": { "compartment": "compartment_70101", "id": "reaction_10572213", "reactome": "R-CEL-9618378", "name": "POM121 binds the Nup107-Nup160 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10507233", "species_10572209" ], "products": [ "species_10572211" ], "modifiers": [], "additional_components": [ "WBGene00003800", "P34343", "WBGene00003801", "Q17872", "WBGene00007493", "Q8T8M4", "WBGene00003792", "Q9N4A7", "WBGene00003806", "Q22078", "WBGene00003788", "O45933", "WBGene00003804", "Q19131", "WBGene00003791", "G5EEH9", "WBGene00003796", "P34343", "WBGene00003801", "Q17872", "WBGene00007493", "Q8T8M4", "WBGene00003792", "Q9N4A7", "WBGene00003806", "Q22078", "WBGene00003788", "O45933", "WBGene00003804", "Q19131", "WBGene00003791", "G5EEH9", "WBGene00003796", "Q17602", "WBGene00003800" ] }, "reaction_10572279": { "compartment": "compartment_70101", "id": "reaction_10572279", "reactome": "R-CEL-9624876", "name": "RAN:GTP recruits nuclear envelope (NE) membranes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9624879", "species_10572267" ], "products": [ "species_10572277" ], "modifiers": [], "additional_components": [ "O17915", "WBGene00004302", "species_29438", "O17915", "WBGene00004302", "species_29438" ] }, "reaction_10572282": { "compartment": "compartment_70101", "id": "reaction_10572282", "reactome": "R-CEL-9624893", "name": "RAN stimulates fusion of nuclear envelope (NE) membranes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10572277" ], "products": [ "species_29372", "species_9624890", "species_10558002" ], "modifiers": [ [ "species_10546252", "catalyst" ] ], "additional_components": [ "O17915", "WBGene00004302", "species_29438", "O17915", "WBGene00004302", "species_29420", "P34342", "WBGene00004303", "P55853", "WBGene00004888" ] }, "reaction_10573042": { "compartment": "compartment_70101", "id": "reaction_10573042", "reactome": "R-CEL-9668389", "name": "VPS4 binds ESCRT-III assemblies at nuclear envelope (NE) fenestrations", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10573038", "species_10573033" ], "products": [ "species_10573040" ], "modifiers": [], "additional_components": [ "WBGene00021334", "Q9U2M8", "WBGene00012578", "G5ECX8", "WBGene00010736", "Q9XTB5", "WBGene00002275", "Q9GYK4", "WBGene00020866", "Q9BL60", "WBGene00022027", "Q9U2F6", "WBGene00012903", "O02208", "WBGene00007216", "Q22718", "WBGene00011976", "Q18886", "WBGene00016961", "Q21959", "WBGene00020025", "Q8MNV0", "WBGene00016045", "Q9U2M8", "WBGene00012578", "G5ECX8", "WBGene00010736", "Q9XTB5", "WBGene00002275", "Q9GYK4", "WBGene00020866", "Q9BL60", "WBGene00022027", "Q9U2F6", "WBGene00012903", "O02208", "WBGene00007216", "Q22718", "WBGene00011976", "Q18886", "WBGene00016961", "Q21959", "WBGene00020025", "Q8MNV0", "WBGene00016045", "Q9BL83", "WBGene00021334" ] }, "reaction_10573044": { "compartment": "compartment_13231", "id": "reaction_10573044", "reactome": "R-CEL-9668395", "name": "CHMP7 binds CC2D1B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10573029", "species_10573025" ], "products": [ "species_10573031" ], "modifiers": [], "additional_components": [ "G5ECX8", "WBGene00010736", "Q9XTB5", "WBGene00002275", "Q9GYK4", "WBGene00020866", "Q9BL60", "WBGene00022027", "Q9U2F6", "WBGene00012903", "O02208", "WBGene00007216", "Q22718", "WBGene00011976", "Q18886", "WBGene00016961", "Q21959", "WBGene00020025", "WBGene00012578", "Q9U2M8", "WBGene00012578", "G5ECX8", "WBGene00010736", "Q9XTB5", "WBGene00002275", "Q9GYK4", "WBGene00020866", "Q9BL60", "WBGene00022027", "Q9U2F6", "WBGene00012903", "O02208", "WBGene00007216", "Q22718", "WBGene00011976", "Q18886", "WBGene00016961", "Q21959", "WBGene00020025" ] }, "reaction_10573046": { "compartment": "compartment_70101", "id": "reaction_10573046", "reactome": "R-CEL-9668405", "name": "SPAST (spastin) binds the IST1 subunit of ESCRT-III at the sites of microtubule attachment to chromatin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10573020", "species_10573031" ], "products": [ "species_10573033" ], "modifiers": [], "additional_components": [ "WBGene00016045", "Q9U2M8", "WBGene00012578", "G5ECX8", "WBGene00010736", "Q9XTB5", "WBGene00002275", "Q9GYK4", "WBGene00020866", "Q9BL60", "WBGene00022027", "Q9U2F6", "WBGene00012903", "O02208", "WBGene00007216", "Q22718", "WBGene00011976", "Q18886", "WBGene00016961", "Q21959", "WBGene00020025", "Q9U2M8", "WBGene00012578", "G5ECX8", "WBGene00010736", "Q9XTB5", "WBGene00002275", "Q9GYK4", "WBGene00020866", "Q9BL60", "WBGene00022027", "Q9U2F6", "WBGene00012903", "O02208", "WBGene00007216", "Q22718", "WBGene00011976", "Q18886", "WBGene00016961", "Q21959", "WBGene00020025", "Q8MNV0", "WBGene00016045" ] }, "reaction_10544436": { "compartment": "compartment_70101", "id": "reaction_10544436", "reactome": "R-CEL-2467775", "name": "Autocleavage of ESPL1 (Separase)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10544425" ], "products": [ "species_10544433" ], "modifiers": [ [ "species_10544425", "catalyst" ] ], "additional_components": [ "WBGene00004775", "G5ED39", "WBGene00004775", "WBGene00004775" ] }, "reaction_10509875": { "compartment": "compartment_7660", "id": "reaction_10509875", "reactome": "R-CEL-156682", "name": "PLK1 phosphorylates NUDC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509869", "species_113592" ], "products": [ "species_29370", "species_10509873" ], "modifiers": [ [ "species_10509861", "catalyst" ] ], "additional_components": [ "WBGene00003829", "WBGene00003829", "WBGene00004043" ] }, "reaction_10572564": { "compartment": "compartment_70101", "id": "reaction_10572564", "reactome": "R-CEL-9647746", "name": "EML4 trimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10572560" ], "products": [ "species_10572562" ], "modifiers": [], "additional_components": [ "WBGene00001248", "O45487", "WBGene00001248" ] }, "reaction_10544760": { "compartment": "compartment_70101", "id": "reaction_10544760", "reactome": "R-CEL-2529015", "name": "Dephosphorylation of CK2-modified condensin I", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10544748" ], "products": [ "species_29372", "species_10544758" ], "modifiers": [ [ "species_2529006", "catalyst" ] ], "additional_components": [ "G5EFJ4", "WBGene00009254", "Q20060", "WBGene00004874", "Q09591", "WBGene00003367", "Q9U2M1", "WBGene00001087", "G5EFJ4", "WBGene00009254", "Q20060", "WBGene00004874", "Q09591", "WBGene00003367", "Q9U2M1", "WBGene00001087" ] }, "reaction_10544762": { "compartment": "compartment_70101", "id": "reaction_10544762", "reactome": "R-CEL-2529020", "name": "CK2 phosphorylates condensin I subunits", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10544758" ], "products": [ "species_10544748", "species_29370" ], "modifiers": [ [ "species_10515097", "catalyst" ] ], "additional_components": [ "G5EFJ4", "WBGene00009254", "Q20060", "WBGene00004874", "Q09591", "WBGene00003367", "Q9U2M1", "WBGene00001087", "G5EFJ4", "WBGene00009254", "Q20060", "WBGene00004874", "Q09591", "WBGene00003367", "Q9U2M1", "WBGene00001087", "P18334", "WBGene00002191", "P28548", "WBGene00002196" ] }, "reaction_10544517": { "compartment": "compartment_1598585", "id": "reaction_10544517", "reactome": "R-CEL-2468293", "name": "CDK1 phosphorylates CDCA5 (Sororin) at chromosomal arms", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10544514" ], "products": [ "species_29370", "species_10544390" ], "modifiers": [ [ "species_10511266", "catalyst" ] ], "additional_components": [ "H2L0H5", "WBGene00019953", "B2FDA8", "WBGene00004873", "Q19555", "WBGene00004738", "O01789", "WBGene00001860", "Q19325", "WBGene00004737", "Q9XUB3", "WBGene00004333", "G5EC05", "WBGene00001352", "H2L0H5", "WBGene00019953", "B2FDA8", "WBGene00004873", "Q19555", "WBGene00004738", "O01789", "WBGene00001860", "Q19325", "WBGene00004737", "Q9XUB3", "WBGene00004333", "G5EC05", "WBGene00001352", "Q10653", "WBGene00000865", "P34556", "WBGene00000405", "Q9BLB5", "WBGene00000867", "O45926", "WBGene00000866" ] }, "reaction_10544410": { "compartment": "compartment_1598585", "id": "reaction_10544410", "reactome": "R-CEL-2466068", "name": "Phosphorylation of cohesin by PLK1 at chromosomal arms", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10544390" ], "products": [ "species_29370", "species_10544407" ], "modifiers": [ [ "species_10511228", "catalyst" ] ], "additional_components": [ "H2L0H5", "WBGene00019953", "B2FDA8", "WBGene00004873", "Q19555", "WBGene00004738", "O01789", "WBGene00001860", "Q19325", "WBGene00004737", "Q9XUB3", "WBGene00004333", "G5EC05", "WBGene00001352", "H2L0H5", "WBGene00019953", "Q19325", "WBGene00004737", "Q9XUB3", "WBGene00004333", "B2FDA8", "WBGene00004873", "Q19555", "WBGene00004738", "O01789", "WBGene00001860", "G5EC05", "WBGene00001352", "WBGene00004043" ] }, "reaction_10544537": { "compartment": "compartment_1598585", "id": "reaction_10544537", "reactome": "R-CEL-2470935", "name": "Cohesin binding to decondensed chromatin is facilitated by NIPBL:MAU2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2537690", "species_10544484", "species_10544529" ], "products": [ "species_10544535" ], "modifiers": [], "additional_components": [ "H2L0H5", "WBGene00019953", "B2FDA8", "WBGene00004873", "Q19325", "WBGene00004737", "Q9XUB3", "WBGene00004333", "Q19555", "WBGene00004738", "O01789", "WBGene00001860", "G5EC05", "WBGene00001352", "O17581", "WBGene00003136", "Q95XZ5", "WBGene00004166", "O17581", "WBGene00003136", "Q95XZ5", "WBGene00004166", "H2L0H5", "WBGene00019953", "B2FDA8", "WBGene00004873", "Q19325", "WBGene00004737", "Q9XUB3", "WBGene00004333", "Q19555", "WBGene00004738", "O01789", "WBGene00001860", "G5EC05", "WBGene00001352" ] }, "reaction_10544508": { "compartment": "compartment_7660", "id": "reaction_10544508", "reactome": "R-CEL-2468040", "name": "Cohesin binds PDS5 and WAPAL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10544478", "species_10544476", "species_10544482" ], "products": [ "species_10544484" ], "modifiers": [], "additional_components": [ "WBGene00001352", "B2FDA8", "WBGene00004873", "Q19325", "WBGene00004737", "Q9XUB3", "WBGene00004333", "Q19555", "WBGene00004738", "O01789", "WBGene00001860", "WBGene00019953", "H2L0H5", "WBGene00019953", "B2FDA8", "WBGene00004873", "Q19325", "WBGene00004737", "Q9XUB3", "WBGene00004333", "Q19555", "WBGene00004738", "O01789", "WBGene00001860", "G5EC05", "WBGene00001352" ] }, "reaction_10509854": { "compartment": "compartment_7660", "id": "reaction_10509854", "reactome": "R-CEL-156673", "name": "Regulation of KIF23 (MKLP1) by phosphorylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10509841" ], "products": [ "species_113582", "species_10509845" ], "modifiers": [ [ "species_10509851", "catalyst" ] ], "additional_components": [ "WBGene00006974", "WBGene00006974", "WBGene00004043" ] }, "reaction_10569693": { "compartment": "compartment_17957", "id": "reaction_10569693", "reactome": "R-CEL-8952289", "name": "FAM20C phosphorylates FAM20C substrates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8931885", "species_10569440" ], "products": [ "species_10569686", "species_8931884" ], "modifiers": [ [ "species_10569440", "catalyst" ], [ "species_10569691", "catalyst" ] ], "additional_components": [ "Q9XTW2", "WBGene00010356", "P49713", "WBGene00012225", "Q22235", "WBGene00011480", "G5EFD9", "WBGene00006324", "H2L2L3", "WBGene00013326", "Q10651", "WBGene00000149", "G5EFX3", "WBGene00013416", "Q9XWD6", "WBGene00000415", "O44565", "WBGene00002247", "Q18823", "WBGene00016913", "Q17770", "WBGene00003963", "A9Z1L1", "WBGene00005648", "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "Q8WQF8", "WBGene00017220", "Q8WQF7", "WBGene00017220", "Q9GZD8", "WBGene00235368", "O01330", "WBGene00235368", "Q9GZD9", "WBGene00235368", "O01331", "WBGene00235368", "Q9GZE0", "WBGene00235368", "P36573", "WBGene00002264", "Q9N384", "WBGene00002269", "C4RVF6", "WBGene00235368", "Q09581", "WBGene00002266", "U4PM93", "WBGene00235368", "G5EFI4", "WBGene00002268", "Q18625", "WBGene00002267", "K8ERT0", "WBGene00235368", "Q20684", "WBGene00002265", "O01329", "WBGene00235368", "G5EBY8", "WBGene00006852", "G5EEL5", "WBGene00000936", "Q8MQ51", "WBGene00009674", "K8F7Z5", "WBGene00008735", "Q7YTU0", "WBGene00013969", "Q11067", "WBGene00015168", "Q11186", "WBGene00015484", "G5EC87", "WBGene00014249", "H2KZY5", "WBGene00018533", "G5EBH7", "WBGene00019760", "Q19687", "WBGene00009008", "P50605", "WBGene00004749", "G5ECM9", "WBGene00000534", "P34714", "WBGene00003893", "Q9N3E0", "WBGene00001046", "Q09EE8", "WBGene00044988", "Q5ZR75", "WBGene00020516", "Q9BL47", "WBGene00022175", "Q18096", "WBGene00007687", "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769", "Q9XTW2", "WBGene00010356", "G5EFD9", "WBGene00006324", "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "H2L2L3", "WBGene00013326", "P49713", "WBGene00012225", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "A9Z1L1", "WBGene00005648", "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "Q10651", "WBGene00000149", "Q9GZE0", "WBGene00235368", "Q9N384", "WBGene00002269", "K8ERT0", "WBGene00235368", "O01329", "WBGene00235368", "U4PM93", "WBGene00235368", "O01330", "WBGene00235368", "O01331", "WBGene00235368", "P36573", "WBGene00002264", "Q09581", "WBGene00002266", "Q18625", "WBGene00002267", "Q20684", "WBGene00002265", "Q9GZD8", "WBGene00235368", "Q9GZD9", "WBGene00235368", "C4RVF6", "WBGene00235368", "G5EFI4", "WBGene00002268", "Q8MQ51", "WBGene00009674", "G5EFX3", "WBGene00013416", "Q9XWD6", "WBGene00000415", "Q17770", "WBGene00003963", "Q8WQF7", "WBGene00017220", "Q8WQF8", "WBGene00017220", "Q22235", "WBGene00011480", "Q11067", "WBGene00015168", "O44565", "WBGene00002247", "Q11186", "WBGene00015484", "G5EC87", "WBGene00014249", "Q18823", "WBGene00016913", "G5EBY8", "WBGene00006852", "G5EEL5", "WBGene00000936", "H2KZY5", "WBGene00018533", "P50605", "WBGene00004749", "Q7YTU0", "WBGene00013969", "K8F7Z5", "WBGene00008735", "P34714", "WBGene00003893", "G5EBH7", "WBGene00019760", "Q09EE8", "WBGene00044988", "Q19687", "WBGene00009008", "Q9BL47", "WBGene00022175", "G5ECM9", "WBGene00000534", "Q18096", "WBGene00007687", "Q9N3E0", "WBGene00001046", "Q5ZR75", "WBGene00020516", "Q9XTW2", "WBGene00010356", "P49713", "WBGene00012225", "Q22235", "WBGene00011480", "G5EFD9", "WBGene00006324", "H2L2L3", "WBGene00013326", "Q10651", "WBGene00000149", "G5EFX3", "WBGene00013416", "Q9XWD6", "WBGene00000415", "O44565", "WBGene00002247", "Q18823", "WBGene00016913", "Q17770", "WBGene00003963", "A9Z1L1", "WBGene00005648", "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "Q8WQF8", "WBGene00017220", "Q8WQF7", "WBGene00017220", "Q9GZD8", "WBGene00235368", "O01330", "WBGene00235368", "Q9GZD9", "WBGene00235368", "O01331", "WBGene00235368", "Q9GZE0", "WBGene00235368", "P36573", "WBGene00002264", "Q9N384", "WBGene00002269", "C4RVF6", "WBGene00235368", "Q09581", "WBGene00002266", "U4PM93", "WBGene00235368", "G5EFI4", "WBGene00002268", "Q18625", "WBGene00002267", "K8ERT0", "WBGene00235368", "Q20684", "WBGene00002265", "O01329", "WBGene00235368", "G5EBY8", "WBGene00006852", "G5EEL5", "WBGene00000936", "Q8MQ51", "WBGene00009674", "K8F7Z5", "WBGene00008735", "Q7YTU0", "WBGene00013969", "Q11067", "WBGene00015168", "Q11186", "WBGene00015484", "G5EC87", "WBGene00014249", "H2KZY5", "WBGene00018533", "G5EBH7", "WBGene00019760", "Q19687", "WBGene00009008", "P50605", "WBGene00004749", "G5ECM9", "WBGene00000534", "P34714", "WBGene00003893", "Q9N3E0", "WBGene00001046", "Q09EE8", "WBGene00044988", "Q5ZR75", "WBGene00020516", "Q9BL47", "WBGene00022175", "Q18096", "WBGene00007687", "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769", "Q9XTW2", "WBGene00010356" ] }, "reaction_10554323": { "compartment": "compartment_70101", "id": "reaction_10554323", "reactome": "R-CEL-5653957", "name": "Rag dimer formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10510565", "species_10510578" ], "products": [ "species_10510580" ], "modifiers": [], "additional_components": [ "Q22743", "WBGene00006414", "species_29438", "species_29420", "G5EGB3", "WBGene00012497", "species_29420", "G5EGB3", "WBGene00012497", "Q22743", "WBGene00006414", "species_29438" ] }, "reaction_10554325": { "compartment": "compartment_17938", "id": "reaction_10554325", "reactome": "R-CEL-5653968", "name": "Ragulator:Rag dimers:SLC38A9 bind mTORC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10510526", "species_10510584" ], "products": [ "species_10510586" ], "modifiers": [], "additional_components": [ "P91040", "WBGene00015697", "Q95Q95", "WBGene00002583", "Q68TI8", "WBGene00000911", "Q19425", "WBGene00008774", "species_29420", "G5EGB3", "WBGene00012497", "Q22743", "WBGene00006414", "species_29438", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "Q19425", "WBGene00008774", "species_29420", "G5EGB3", "WBGene00012497", "Q22743", "WBGene00006414", "species_29438", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "P91040", "WBGene00015697", "Q95Q95", "WBGene00002583", "Q68TI8", "WBGene00000911" ] }, "reaction_10554902": { "compartment": "compartment_17938", "id": "reaction_10554902", "reactome": "R-CEL-5672828", "name": "mTORC1 phosphorylates AKT1S1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10510629" ], "products": [ "species_29370", "species_10554899" ], "modifiers": [ [ "species_10510629", "catalyst" ] ], "additional_components": [ "Q19425", "WBGene00008774", "species_29420", "G5EGB3", "WBGene00012497", "Q22743", "WBGene00006414", "species_29438", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "P91040", "WBGene00015697", "Q95Q95", "WBGene00002583", "Q68TI8", "WBGene00000911", "P34443", "WBGene00010038", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "Q19425", "WBGene00008774", "species_29420", "G5EGB3", "WBGene00012497", "Q22743", "WBGene00006414", "species_29438", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "P91040", "WBGene00015697", "Q95Q95", "WBGene00002583", "Q68TI8", "WBGene00000911", "P34443", "WBGene00010038", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "Q19425", "WBGene00008774", "species_29420", "G5EGB3", "WBGene00012497", "Q22743", "WBGene00006414", "species_29438", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "P91040", "WBGene00015697", "Q95Q95", "WBGene00002583", "Q68TI8", "WBGene00000911", "P34443", "WBGene00010038", "P41932", "WBGene00003920", "Q20655", "WBGene00001502" ] }, "reaction_10569771": { "compartment": "compartment_70101", "id": "reaction_10569771", "reactome": "R-CEL-8952726", "name": "SLC38A9 transports L-Arg from lysosomal lumen to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428011" ], "products": [ "species_29468" ], "modifiers": [ [ "species_10510584", "catalyst" ] ], "additional_components": [ "Q19425", "WBGene00008774", "species_29420", "G5EGB3", "WBGene00012497", "Q22743", "WBGene00006414", "species_29438", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390" ] }, "reaction_10554893": { "compartment": "compartment_17938", "id": "reaction_10554893", "reactome": "R-CEL-5672824", "name": "Phosphorylated AKT1S1:mTORC1 binds YWHAB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10507065", "species_10510627" ], "products": [ "species_10510629" ], "modifiers": [], "additional_components": [ "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "Q19425", "WBGene00008774", "species_29420", "G5EGB3", "WBGene00012497", "Q22743", "WBGene00006414", "species_29438", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "P91040", "WBGene00015697", "Q95Q95", "WBGene00002583", "Q68TI8", "WBGene00000911", "P34443", "WBGene00010038", "Q19425", "WBGene00008774", "species_29420", "G5EGB3", "WBGene00012497", "Q22743", "WBGene00006414", "species_29438", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "P91040", "WBGene00015697", "Q95Q95", "WBGene00002583", "Q68TI8", "WBGene00000911", "P34443", "WBGene00010038", "P41932", "WBGene00003920", "Q20655", "WBGene00001502" ] }, "reaction_10510643": { "compartment": "compartment_70101", "id": "reaction_10510643", "reactome": "R-CEL-165726", "name": "Phosphorylation of Ribosomal protein S6 by activated S6K1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10505506" ], "products": [ "species_29370", "species_10510640" ], "modifiers": [ [ "species_10510612", "catalyst" ] ], "additional_components": [ "WBGene00004475", "WBGene00004475", "Q9NAH6", "WBGene00012929", "Q21694", "WBGene00044281" ] }, "reaction_10510660": { "compartment": "compartment_70101", "id": "reaction_10510660", "reactome": "R-CEL-165766", "name": "Phosphorylation and activation of eIF4G by activated S6K1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10505665" ], "products": [ "species_29370", "species_10510658" ], "modifiers": [ [ "species_10510612", "catalyst" ] ], "additional_components": [ "WBGene00002066", "WBGene00002066", "Q9NAH6", "WBGene00012929", "Q21694", "WBGene00044281" ] }, "reaction_10510631": { "compartment": "compartment_17938", "id": "reaction_10510631", "reactome": "R-CEL-165718", "name": "mTORC1 phosphorylation of RPS6KB1 (S6K)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10510602", "species_113592" ], "products": [ "species_29370", "species_10510612" ], "modifiers": [ [ "species_10510588", "catalyst" ], [ "species_10510629", "catalyst" ], [ "species_10510623", "inhibitor" ] ], "additional_components": [ "Q21694", "WBGene00044281", "Q9NAH6", "WBGene00012929", "Q9NAH6", "WBGene00012929", "Q21694", "WBGene00044281", "Q19425", "WBGene00008774", "species_29420", "G5EGB3", "WBGene00012497", "Q22743", "WBGene00006414", "species_29438", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "P91040", "WBGene00015697", "Q95Q95", "WBGene00002583", "Q68TI8", "WBGene00000911", "P34443", "WBGene00010038", "Q19425", "WBGene00008774", "species_29420", "G5EGB3", "WBGene00012497", "Q22743", "WBGene00006414", "species_29438", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "P91040", "WBGene00015697", "Q95Q95", "WBGene00002583", "Q68TI8", "WBGene00000911", "P34443", "WBGene00010038", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "P34443", "WBGene00010038", "species_29438", "Q19425", "WBGene00008774", "species_29420", "G5EGB3", "WBGene00012497", "Q22743", "WBGene00006414", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "P91040", "WBGene00015697", "Q95Q95", "WBGene00002583", "Q68TI8", "WBGene00000911" ] }, "reaction_10510665": { "compartment": "compartment_70101", "id": "reaction_10510665", "reactome": "R-CEL-165777", "name": "Phosphorylation and activation of eIF4B by activated S6K1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10505672" ], "products": [ "species_29370", "species_10510663" ], "modifiers": [ [ "species_10510612", "catalyst" ] ], "additional_components": [ "WBGene00019157", "WBGene00019157", "Q9NAH6", "WBGene00012929", "Q21694", "WBGene00044281" ] }, "reaction_10510653": { "compartment": "compartment_70101", "id": "reaction_10510653", "reactome": "R-CEL-165758", "name": "Phosphorylation and inactivation of eEF2K by activated S6K1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10510648" ], "products": [ "species_10510651", "species_29370" ], "modifiers": [ [ "species_10510612", "catalyst" ] ], "additional_components": [ "WBGene00001160", "WBGene00001160", "Q9NAH6", "WBGene00012929", "Q21694", "WBGene00044281" ] }, "reaction_10519956": { "compartment": "compartment_70101", "id": "reaction_10519956", "reactome": "R-CEL-380930", "name": "Phosphorylated AMPK binds AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10514570", "species_76577" ], "products": [ "species_10519954" ], "modifiers": [], "additional_components": [ "Q9XUY2", "WBGene00010115", "P45894", "WBGene00019801", "Q95ZQ4", "WBGene00020142", "A0A1T5HUK9", "WBGene00013732", "H2L0K0", "WBGene00020135", "O02168", "WBGene00020633", "Q9N501", "WBGene00021527", "species_76577", "Q9XUY2", "WBGene00010115", "P45894", "WBGene00019801", "Q95ZQ4", "WBGene00020142", "A0A1T5HUK9", "WBGene00013732", "H2L0K0", "WBGene00020135", "O02168", "WBGene00020633", "Q9N501", "WBGene00021527" ] }, "reaction_10525223": { "compartment": "compartment_876", "id": "reaction_10525223", "reactome": "R-CEL-447074", "name": "AMPK phosphorylates Raptor in the mTORC1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10510588", "species_113592" ], "products": [ "species_10510623", "species_29370" ], "modifiers": [ [ "species_10519954", "catalyst" ] ], "additional_components": [ "Q19425", "WBGene00008774", "species_29420", "G5EGB3", "WBGene00012497", "Q22743", "WBGene00006414", "species_29438", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "P91040", "WBGene00015697", "Q95Q95", "WBGene00002583", "Q68TI8", "WBGene00000911", "P34443", "WBGene00010038", "P34443", "WBGene00010038", "species_29438", "Q19425", "WBGene00008774", "species_29420", "G5EGB3", "WBGene00012497", "Q22743", "WBGene00006414", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "P91040", "WBGene00015697", "Q95Q95", "WBGene00002583", "Q68TI8", "WBGene00000911", "species_76577", "Q9XUY2", "WBGene00010115", "P45894", "WBGene00019801", "Q95ZQ4", "WBGene00020142", "A0A1T5HUK9", "WBGene00013732", "H2L0K0", "WBGene00020135", "O02168", "WBGene00020633", "Q9N501", "WBGene00021527" ] }, "reaction_10519961": { "compartment": "compartment_70101", "id": "reaction_10519961", "reactome": "R-CEL-380949", "name": "AMPK is dephosphorylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10514570" ], "products": [ "species_29372", "species_10514555" ], "modifiers": [ [ "species_10519958", "catalyst" ] ], "additional_components": [ "Q9XUY2", "WBGene00010115", "P45894", "WBGene00019801", "Q95ZQ4", "WBGene00020142", "A0A1T5HUK9", "WBGene00013732", "H2L0K0", "WBGene00020135", "O02168", "WBGene00020633", "Q9N501", "WBGene00021527", "Q9XUY2", "WBGene00010115", "A0A1T5HUK9", "WBGene00013732", "H2L0K0", "WBGene00020135", "O02168", "WBGene00020633", "Q9N501", "WBGene00021527", "P45894", "WBGene00019801", "Q95ZQ4", "WBGene00020142", "WBGene00006460" ] }, "reaction_10510509": { "compartment": "compartment_17938", "id": "reaction_10510509", "reactome": "R-CEL-165195", "name": "GTP loading by Rheb", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10510505" ], "products": [ "species_29420", "species_10510507" ], "modifiers": [], "additional_components": [ "P34443", "WBGene00010038", "species_29420", "P34443", "WBGene00010038", "species_29438" ] }, "reaction_10510590": { "compartment": "compartment_70101", "id": "reaction_10510590", "reactome": "R-CEL-165680", "name": "Formation of active mTORC1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10510507", "species_10510586" ], "products": [ "species_10510588" ], "modifiers": [], "additional_components": [ "P34443", "WBGene00010038", "species_29438", "Q19425", "WBGene00008774", "species_29420", "G5EGB3", "WBGene00012497", "Q22743", "WBGene00006414", "species_29438", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "P91040", "WBGene00015697", "Q95Q95", "WBGene00002583", "Q68TI8", "WBGene00000911", "Q19425", "WBGene00008774", "species_29420", "G5EGB3", "WBGene00012497", "Q22743", "WBGene00006414", "species_29438", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "P91040", "WBGene00015697", "Q95Q95", "WBGene00002583", "Q68TI8", "WBGene00000911", "P34443", "WBGene00010038" ] }, "reaction_10519535": { "compartment": "compartment_17938", "id": "reaction_10519535", "reactome": "R-CEL-377186", "name": "Activated Akt1 phosphorylates AKT1S1 (PRAS40)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10519532", "species_113592" ], "products": [ "species_29370", "species_10510627" ], "modifiers": [ [ "species_10515152", "catalyst" ] ], "additional_components": [ "Q19425", "WBGene00008774", "species_29420", "G5EGB3", "WBGene00012497", "Q22743", "WBGene00006414", "species_29438", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "P91040", "WBGene00015697", "Q95Q95", "WBGene00002583", "Q68TI8", "WBGene00000911", "P34443", "WBGene00010038", "Q19425", "WBGene00008774", "species_29420", "G5EGB3", "WBGene00012497", "Q22743", "WBGene00006414", "species_29438", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "P91040", "WBGene00015697", "Q95Q95", "WBGene00002583", "Q68TI8", "WBGene00000911", "P34443", "WBGene00010038", "G4S4W1", "WBGene00016980", "Q17941", "WBGene00000102", "Q9XTG7", "WBGene00000103" ] }, "reaction_10509895": { "compartment": "compartment_70101", "id": "reaction_10509895", "reactome": "R-CEL-156823", "name": "Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509886", "species_10509891" ], "products": [ "species_10509893" ], "modifiers": [], "additional_components": [ "A0A486WX07", "WBGene00002066", "Q20935", "WBGene00018997", "P27639", "WBGene00002083", "O61955", "WBGene00002061", "species_29438", "Q9BKU3", "WBGene00021351", "Q21230", "WBGene00010560", "Q95XR0", "WBGene00021466", "P51403", "WBGene00004471", "Q9NEN6", "WBGene00004475", "Q8WQA8", "WBGene00004489", "Q23312", "WBGene00004476", "O01869", "WBGene00004479", "P49197", "WBGene00004490", "P48156", "WBGene00004477", "Q20206", "WBGene00004480", "Q19877", "WBGene00004492", "Q20228", "WBGene00004478", "P49196", "WBGene00004481", "Q1XFY9", "WBGene00004493", "P46769", "WBGene00004469", "P51404", "WBGene00004482", "P52821", "WBGene00004494", "Q9TXP0", "WBGene00004496", "P48150", "WBGene00004483", "O45499", "WBGene00004495", "Q9N3X2", "WBGene00004473", "Q9XVP0", "WBGene00004484", "Q95Y04", "WBGene00004497", "Q22054", "WBGene00004485", "P90983", "WBGene00004498", "O01692", "WBGene00004486", "P48152", "WBGene00004472", "O18240", "WBGene00004487", "O18650", "WBGene00004488", "P48154", "WBGene00004470", "O17218", "WBGene00004491", "P49041", "WBGene00004474", "Q95QW0", "WBGene00015920", "O01974", "WBGene00001231", "Q94261", "WBGene00019543", "P34339", "WBGene00001209", "Q9XWP7", "WBGene00012738", "P30642", "WBGene00001227", "Q965S8", "WBGene00001232", "O02328", "WBGene00001226", "Q19706", "WBGene00001230", "O61820", "WBGene00001228", "Q18967", "WBGene00001229", "Q9XUP3", "WBGene00001233", "Q9XWI6", "WBGene00001225", "Q9TXU7", "WBGene00019162", "H2L0A8", "WBGene00019157", "Q9U302", "WBGene00003902", "WBGene00004428", "Q27389", "WBGene00004428", "A0A486WX07", "WBGene00002066", "Q20935", "WBGene00018997", "P27639", "WBGene00002083", "O61955", "WBGene00002061", "species_29438", "Q9BKU3", "WBGene00021351", "Q21230", "WBGene00010560", "Q95XR0", "WBGene00021466", "P51403", "WBGene00004471", "Q9NEN6", "WBGene00004475", "Q8WQA8", "WBGene00004489", "Q23312", "WBGene00004476", "O01869", "WBGene00004479", "P49197", "WBGene00004490", "P48156", "WBGene00004477", "Q20206", "WBGene00004480", "Q19877", "WBGene00004492", "Q20228", "WBGene00004478", "P49196", "WBGene00004481", "Q1XFY9", "WBGene00004493", "P46769", "WBGene00004469", "P51404", "WBGene00004482", "P52821", "WBGene00004494", "Q9TXP0", "WBGene00004496", "P48150", "WBGene00004483", "O45499", "WBGene00004495", "Q9N3X2", "WBGene00004473", "Q9XVP0", "WBGene00004484", "Q95Y04", "WBGene00004497", "Q22054", "WBGene00004485", "P90983", "WBGene00004498", "O01692", "WBGene00004486", "P48152", "WBGene00004472", "O18240", "WBGene00004487", "O18650", "WBGene00004488", "P48154", "WBGene00004470", "O17218", "WBGene00004491", "P49041", "WBGene00004474", "Q95QW0", "WBGene00015920", "O01974", "WBGene00001231", "Q94261", "WBGene00019543", "P34339", "WBGene00001209", "Q9XWP7", "WBGene00012738", "P30642", "WBGene00001227", "Q965S8", "WBGene00001232", "O02328", "WBGene00001226", "Q19706", "WBGene00001230", "O61820", "WBGene00001228", "Q18967", "WBGene00001229", "Q9XUP3", "WBGene00001233", "Q9XWI6", "WBGene00001225", "Q9TXU7", "WBGene00019162", "H2L0A8", "WBGene00019157", "Q9U302", "WBGene00003902" ] }, "reaction_10509899": { "compartment": "compartment_70101", "id": "reaction_10509899", "reactome": "R-CEL-156826", "name": "Dissociation of L13a from the 60s ribosomal subunit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10505970" ], "products": [ "species_10509897", "species_10505768" ], "modifiers": [], "additional_components": [ "P91914", "WBGene00004441", "Q19869", "WBGene00004440", "O01868", "WBGene00004436", "P48162", "WBGene00004438", "P52819", "WBGene00004434", "P48158", "WBGene00004435", "Q09533", "WBGene00004421", "P34334", "WBGene00004433", "O02639", "WBGene00004431", "Q95Y90", "WBGene00004420", "O44480", "WBGene00004432", "Q22716", "WBGene00004446", "Q9U332", "WBGene00004445", "Q9XWS4", "WBGene00004444", "P52814", "WBGene00004453", "O45226", "WBGene00004443", "Q21930", "WBGene00004442", "P48166", "WBGene00004454", "Q9BKU5", "WBGene00021350", "P50880", "WBGene00004414", "P61866", "WBGene00004424", "O17570", "WBGene00004452", "Q19162", "WBGene00004423", "Q9U2A8", "WBGene00004456", "Q9N4I4", "WBGene00004412", "O62388", "WBGene00012179", "O01504", "WBGene00016493", "P49181", "WBGene00004450", "P91913", "WBGene00004409", "P49180", "WBGene00004447", "Q93572", "WBGene00004408", "P34662", "WBGene00004449", "Q9XVF7", "WBGene00004413", "O45946", "WBGene00004430", "Q966C6", "WBGene00004419", "Q9BL19", "WBGene00004429", "O01802", "WBGene00004418", "P91374", "WBGene00004427", "P47991", "WBGene00004417", "Q9XVE9", "WBGene00004426", "P49405", "WBGene00004416", "Q27389", "WBGene00004428", "P37165", "WBGene00006725", "P91128", "WBGene00004425", "O02056", "WBGene00004415", "P91914", "WBGene00004441", "Q19869", "WBGene00004440", "O01868", "WBGene00004436", "P48162", "WBGene00004438", "P52819", "WBGene00004434", "P48158", "WBGene00004435", "Q09533", "WBGene00004421", "P34334", "WBGene00004433", "O02639", "WBGene00004431", "Q95Y90", "WBGene00004420", "O44480", "WBGene00004432", "Q22716", "WBGene00004446", "Q9U332", "WBGene00004445", "Q9XWS4", "WBGene00004444", "P52814", "WBGene00004453", "O45226", "WBGene00004443", "Q21930", "WBGene00004442", "P48166", "WBGene00004454", "Q9BKU5", "WBGene00021350", "P50880", "WBGene00004414", "P61866", "WBGene00004424", "O17570", "WBGene00004452", "Q19162", "WBGene00004423", "Q9U2A8", "WBGene00004456", "Q9N4I4", "WBGene00004412", "O62388", "WBGene00012179", "O01504", "WBGene00016493", "P49181", "WBGene00004450", "P91913", "WBGene00004409", "P49180", "WBGene00004447", "Q93572", "WBGene00004408", "P34662", "WBGene00004449", "Q9XVF7", "WBGene00004413", "O45946", "WBGene00004430", "Q966C6", "WBGene00004419", "Q9BL19", "WBGene00004429", "O01802", "WBGene00004418", "P91374", "WBGene00004427", "P47991", "WBGene00004417", "Q9XVE9", "WBGene00004426", "P49405", "WBGene00004416", "P37165", "WBGene00006725", "P91128", "WBGene00004425", "O02056", "WBGene00004415", "WBGene00004428" ] }, "reaction_10550786": { "compartment": "compartment_70101", "id": "reaction_10550786", "reactome": "R-CEL-5228992", "name": "ROCK1,ROCK2 are activated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10521951" ], "products": [ "species_10550784" ], "modifiers": [], "additional_components": [ "Q22038", "WBGene00004357", "species_29438", "P92199", "WBGene00002694", "Q21025", "WBGene00019087", "Q9XVH4", "WBGene00019087", "species_114632", "Q22038", "WBGene00004357", "species_29438", "P92199", "WBGene00002694", "Q21025", "WBGene00019087", "Q9XVH4", "WBGene00019087" ] }, "reaction_10550628": { "compartment": "compartment_876", "id": "reaction_10550628", "reactome": "R-CEL-5218812", "name": "FYN phosphorylates PAK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10550625" ], "products": [ "species_29370", "species_10550576" ], "modifiers": [ [ "species_10550625", "catalyst" ] ], "additional_components": [ "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "G5EGT9", "WBGene00003007", "A0A1I6CMA1", "WBGene00020678", "Q95PX0", "WBGene00006410", "Q05062", "WBGene00000390", "species_29438", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "G5EGT9", "WBGene00003007", "A0A1I6CMA1", "WBGene00020678", "Q95PX0", "WBGene00006410", "Q05062", "WBGene00000390", "species_29438", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "G5EGT9", "WBGene00003007", "A0A1I6CMA1", "WBGene00020678", "Q95PX0", "WBGene00006410", "Q05062", "WBGene00000390", "species_29438", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911" ] }, "reaction_10550693": { "compartment": "compartment_70101", "id": "reaction_10550693", "reactome": "R-CEL-5218916", "name": "p-MAPK2/3 phosphorylates HSP27", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10550685", "species_113592" ], "products": [ "species_10523755", "species_29370", "species_10550690" ], "modifiers": [ [ "species_10512646", "catalyst" ] ], "additional_components": [ "P0DM41", "WBGene00000063", "P0DM42", "WBGene00000065", "P10984", "WBGene00000064", "P10986", "WBGene00000066", "species_29358", "Q17849", "WBGene00002023", "P0DM41", "WBGene00000063", "P0DM42", "WBGene00000065", "P10984", "WBGene00000064", "P10986", "WBGene00000066", "species_29358", "WBGene00002023", "Q21360", "WBGene00010681", "Q965G5", "WBGene00007007" ] }, "reaction_10550665": { "compartment": "compartment_876", "id": "reaction_10550665", "reactome": "R-CEL-5218832", "name": "CDC42:GTP binds PAK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10550663", "species_10512279" ], "products": [ "species_10550636" ], "modifiers": [], "additional_components": [ "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "G5EGT9", "WBGene00003007", "A0A1I6CMA1", "WBGene00020678", "Q95PX0", "WBGene00006410", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "Q05062", "WBGene00000390", "species_29438", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "G5EGT9", "WBGene00003007", "A0A1I6CMA1", "WBGene00020678", "Q95PX0", "WBGene00006410", "Q05062", "WBGene00000390", "species_29438", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911" ] }, "reaction_10550667": { "compartment": "compartment_876", "id": "reaction_10550667", "reactome": "R-CEL-5218847", "name": "PAK2 binds NCK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10520680", "species_10550562" ], "products": [ "species_10550663" ], "modifiers": [], "additional_components": [ "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "G5EGT9", "WBGene00003007", "A0A1I6CMA1", "WBGene00020678", "Q95PX0", "WBGene00006410", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "G5EGT9", "WBGene00003007", "A0A1I6CMA1", "WBGene00020678", "Q95PX0", "WBGene00006410", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911" ] }, "reaction_10550639": { "compartment": "compartment_876", "id": "reaction_10550639", "reactome": "R-CEL-5218814", "name": "PAK2 autophorylates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10550636", "species_113592" ], "products": [ "species_29370", "species_10550625" ], "modifiers": [ [ "species_10550636", "catalyst" ] ], "additional_components": [ "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "G5EGT9", "WBGene00003007", "A0A1I6CMA1", "WBGene00020678", "Q95PX0", "WBGene00006410", "Q05062", "WBGene00000390", "species_29438", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "G5EGT9", "WBGene00003007", "A0A1I6CMA1", "WBGene00020678", "Q95PX0", "WBGene00006410", "Q05062", "WBGene00000390", "species_29438", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "G5EGT9", "WBGene00003007", "A0A1I6CMA1", "WBGene00020678", "Q95PX0", "WBGene00006410", "Q05062", "WBGene00000390", "species_29438", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911" ] }, "reaction_10550610": { "compartment": "compartment_70101", "id": "reaction_10550610", "reactome": "R-CEL-5218805", "name": "PKC autophosphorylates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10550592" ], "products": [ "species_10550607", "species_29370" ], "modifiers": [ [ "species_10550592", "catalyst" ] ], "additional_components": [ "Q19266", "WBGene00004034", "P90980", "WBGene00004033", "P34722", "WBGene00006599", "Q19266", "WBGene00004034", "P90980", "WBGene00004033", "P34722", "WBGene00006599", "Q19266", "WBGene00004034", "P90980", "WBGene00004033", "P34722", "WBGene00006599" ] }, "reaction_10550659": { "compartment": "compartment_876", "id": "reaction_10550659", "reactome": "R-CEL-5218823", "name": "PKC phosphorylates sphingosine kinase 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10520872" ], "products": [ "species_29370", "species_10550656" ], "modifiers": [ [ "species_10550630", "catalyst" ] ], "additional_components": [ "WBGene00007918", "WBGene00007918", "species_74016", "species_112275", "Q19266", "WBGene00004034", "P90980", "WBGene00004033", "P34722", "WBGene00006599" ] }, "reaction_10550653": { "compartment": "compartment_876", "id": "reaction_10550653", "reactome": "R-CEL-5218821", "name": "PDK1 phosphorylates PKC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10550650", "species_113592" ], "products": [ "species_29370", "species_10550592" ], "modifiers": [ [ "species_10508528", "catalyst" ] ], "additional_components": [ "P90980", "WBGene00004033", "Q19266", "WBGene00004034", "P34722", "WBGene00006599", "Q19266", "WBGene00004034", "P90980", "WBGene00004033", "P34722", "WBGene00006599", "WBGene00021022" ] }, "reaction_10550579": { "compartment": "compartment_70101", "id": "reaction_10550579", "reactome": "R-CEL-5218804", "name": "p38 MAPK activation by VEGFR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10526151" ], "products": [ "species_29370", "species_10512658" ], "modifiers": [ [ "species_10550576", "catalyst" ] ], "additional_components": [ "Q17446", "WBGene00004055", "Q8MXI4", "WBGene00004056", "species_114632", "Q17446", "WBGene00004055", "Q8MXI4", "WBGene00004056", "species_114632", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "G5EGT9", "WBGene00003007", "A0A1I6CMA1", "WBGene00020678", "Q95PX0", "WBGene00006410", "Q05062", "WBGene00000390", "species_29438", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911" ] }, "reaction_10548788": { "compartment": "compartment_876", "id": "reaction_10548788", "reactome": "R-CEL-3928647", "name": "RHOA:GTP:Mg2+ binds ROCK1,ROCK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10521949", "species_10509488" ], "products": [ "species_10521951" ], "modifiers": [], "additional_components": [ "P92199", "WBGene00002694", "Q21025", "WBGene00019087", "Q9XVH4", "WBGene00019087", "Q22038", "WBGene00004357", "species_29438", "Q22038", "WBGene00004357", "species_29438", "P92199", "WBGene00002694", "Q21025", "WBGene00019087", "Q9XVH4", "WBGene00019087" ] }, "reaction_10550644": { "compartment": "compartment_876", "id": "reaction_10550644", "reactome": "R-CEL-5218819", "name": "VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10550641", "catalyst" ] ], "additional_components": [ "G5EGT9", "WBGene00003007", "A0A1I6CMA1", "WBGene00020678", "G5EDP9", "WBGene00000001", "Q94125", "WBGene00000090" ] }, "reaction_10569044": { "compartment": "compartment_876", "id": "reaction_10569044", "reactome": "R-CEL-8951586", "name": "p-VAV family:PIP3 binds RAC1:GDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10541992", "species_10550646" ], "products": [ "species_10550669" ], "modifiers": [], "additional_components": [ "species_29420", "Q03206", "ced-10", "Q45FX5", "WBGene00006887", "species_179838", "Q45FX5", "WBGene00006887", "species_179838", "species_29420", "Q03206", "ced-10" ] }, "reaction_10551522": { "compartment": "compartment_876", "id": "reaction_10551522", "reactome": "R-CEL-5357445", "name": "PAK1-3 dimer disassociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10551518" ], "products": [ "species_10551520" ], "modifiers": [], "additional_components": [ "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "species_29438", "Q03206", "ced-10", "Q45FX5", "WBGene00006887", "species_179838", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "species_29438", "Q03206", "ced-10", "Q45FX5", "WBGene00006887", "species_179838" ] }, "reaction_10551525": { "compartment": "compartment_876", "id": "reaction_10551525", "reactome": "R-CEL-5357472", "name": "PAK1-3 autophosphorylates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10551520" ], "products": [ "species_10550671", "species_29370", "species_10521284" ], "modifiers": [ [ "species_10520686", "catalyst" ] ], "additional_components": [ "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "species_29438", "Q03206", "ced-10", "Q45FX5", "WBGene00006887", "species_179838", "species_29438", "Q03206", "ced-10", "Q45FX5", "WBGene00006887", "species_179838", "Q17850", "WBGene00003911", "G5EGQ3", "WBGene00003144", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911" ] }, "reaction_10551558": { "compartment": "compartment_876", "id": "reaction_10551558", "reactome": "R-CEL-5357477", "name": "PAK1-3 phosphorylates VE-cadherin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10551551", "species_113592" ], "products": [ "species_29370", "species_10551555" ], "modifiers": [ [ "species_10521284", "catalyst" ] ], "additional_components": [ "Q9U308", "WBGene00002175", "P90947", "WBGene00001978", "Q10953", "WBGene00006943", "Q18825", "WBGene00000238", "O44326", "WBGene00001979", "Q9U308", "WBGene00002175", "P90947", "WBGene00001978", "Q10953", "WBGene00006943", "Q18825", "WBGene00000238", "O44326", "WBGene00001979", "Q17850", "WBGene00003911", "G5EGQ3", "WBGene00003144" ] }, "reaction_10551560": { "compartment": "compartment_876", "id": "reaction_10551560", "reactome": "R-CEL-5357483", "name": "RAC1 binds PAK1-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10550671", "species_10520686" ], "products": [ "species_10551518" ], "modifiers": [], "additional_components": [ "species_29438", "Q03206", "ced-10", "Q45FX5", "WBGene00006887", "species_179838", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "species_29438", "Q03206", "ced-10", "Q45FX5", "WBGene00006887", "species_179838" ] }, "reaction_10515164": { "compartment": "compartment_70101", "id": "reaction_10515164", "reactome": "R-CEL-202111", "name": "AKT1 phosphorylates eNOS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10515154" ], "products": [ "species_29370", "species_10515162" ], "modifiers": [], "additional_components": [ "G4S4W1", "WBGene00016980", "Q17941", "WBGene00000102", "Q9XTG7", "WBGene00000103", "species_74016", "O16305", "WBGene00000552", "P04630", "WBGene00000285", "Q09665", "WBGene00006583", "A0A2C9C3L3", "WBGene00020378", "Q09980", "WBGene00017394", "G5EDZ8", "WBGene00000288", "Q11083", "WBGene00020378", "G5EEG0", "WBGene00000286", "Q18136", "WBGene00006861", "G5EF37", "WBGene00003934", "Q94288", "WBGene00000287", "O02159", "WBGene00020378", "species_71185", "species_216785", "species_73524", "species_113596", "Q18688", "WBGene00000915", "Q9XTG7", "WBGene00000103", "G4S4W1", "WBGene00016980", "Q17941", "WBGene00000102", "species_74016", "Q11083", "WBGene00020378", "P04630", "WBGene00000285", "G5EF37", "WBGene00003934", "A0A2C9C3L3", "WBGene00020378", "Q18136", "WBGene00006861", "Q09665", "WBGene00006583", "O02159", "WBGene00020378", "G5EDZ8", "WBGene00000288", "Q94288", "WBGene00000287", "Q09980", "WBGene00017394", "O16305", "WBGene00000552", "G5EEG0", "WBGene00000286", "Q18688", "WBGene00000915", "species_71185", "species_216785", "species_73524", "species_113596", "species_29870" ] }, "reaction_10535150": { "compartment": "compartment_70101", "id": "reaction_10535150", "reactome": "R-CEL-1497784", "name": "The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29870", "species_10515162" ], "products": [ "species_10515166" ], "modifiers": [], "additional_components": [ "Q9XTG7", "WBGene00000103", "G4S4W1", "WBGene00016980", "Q17941", "WBGene00000102", "species_74016", "Q11083", "WBGene00020378", "P04630", "WBGene00000285", "G5EF37", "WBGene00003934", "A0A2C9C3L3", "WBGene00020378", "Q18136", "WBGene00006861", "Q09665", "WBGene00006583", "O02159", "WBGene00020378", "G5EDZ8", "WBGene00000288", "Q94288", "WBGene00000287", "Q09980", "WBGene00017394", "O16305", "WBGene00000552", "G5EEG0", "WBGene00000286", "Q18688", "WBGene00000915", "species_71185", "species_216785", "species_73524", "species_113596", "species_29870", "Q9XTG7", "WBGene00000103", "G4S4W1", "WBGene00016980", "Q17941", "WBGene00000102", "species_74016", "Q11083", "WBGene00020378", "P04630", "WBGene00000285", "G5EF37", "WBGene00003934", "A0A2C9C3L3", "WBGene00020378", "Q18136", "WBGene00006861", "Q09665", "WBGene00006583", "O02159", "WBGene00020378", "G5EDZ8", "WBGene00000288", "Q94288", "WBGene00000287", "Q09980", "WBGene00017394", "O16305", "WBGene00000552", "G5EEG0", "WBGene00000286", "Q18688", "WBGene00000915", "species_71185", "species_216785", "species_73524", "species_113596", "species_29870" ] }, "reaction_10550679": { "compartment": "compartment_70101", "id": "reaction_10550679", "reactome": "R-CEL-5218854", "name": "p-Y420-FYN is phosphorylated on S21", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10550614" ], "products": [ "species_29370", "species_10550562" ], "modifiers": [ [ "species_10550676", "catalyst" ] ], "additional_components": [ "G5EGT9", "WBGene00003007", "A0A1I6CMA1", "WBGene00020678", "Q95PX0", "WBGene00006410", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "G5EGT9", "WBGene00003007", "A0A1I6CMA1", "WBGene00020678", "Q95PX0", "WBGene00006410" ] }, "reaction_10550617": { "compartment": "compartment_876", "id": "reaction_10550617", "reactome": "R-CEL-5218806", "name": "FYN autophosphorylates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10550612" ], "products": [ "species_29370", "species_10550614" ], "modifiers": [ [ "species_10550612", "catalyst" ] ], "additional_components": [ "G5EGT9", "WBGene00003007", "A0A1I6CMA1", "WBGene00020678", "Q95PX0", "WBGene00006410", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "G5EGT9", "WBGene00003007", "A0A1I6CMA1", "WBGene00020678", "Q95PX0", "WBGene00006410", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "G5EGT9", "WBGene00003007", "A0A1I6CMA1", "WBGene00020678", "Q95PX0", "WBGene00006410", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635" ] }, "reaction_10565172": { "compartment": "compartment_70101", "id": "reaction_10565172", "reactome": "R-CEL-8851933", "name": "MET phosphorylates GAB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10565169" ], "products": [ "species_29370", "species_10543879" ], "modifiers": [ [ "species_10565169", "catalyst" ] ], "additional_components": [ "Q9XVQ7", "WBGene00008711", "G5EDJ4", "WBGene00004928", "P29355", "WBGene00004774", "G5EDJ4", "WBGene00004928", "Q9XVQ7", "WBGene00008711", "P29355", "WBGene00004774", "Q9XVQ7", "WBGene00008711", "G5EDJ4", "WBGene00004928", "P29355", "WBGene00004774" ] }, "reaction_10565174": { "compartment": "compartment_70101", "id": "reaction_10565174", "reactome": "R-CEL-8851954", "name": "Phosphorylated GAB1 recruits PI3K to MET", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10506892", "species_10543879" ], "products": [ "species_10543881" ], "modifiers": [], "additional_components": [ "G5EDP9", "WBGene00000001", "Q94125", "WBGene00000090", "G5EDJ4", "WBGene00004928", "Q9XVQ7", "WBGene00008711", "P29355", "WBGene00004774", "G5EDJ4", "WBGene00004928", "Q9XVQ7", "WBGene00008711", "P29355", "WBGene00004774", "G5EDP9", "WBGene00000001", "Q94125", "WBGene00000090" ] }, "reaction_10565177": { "compartment": "compartment_70101", "id": "reaction_10565177", "reactome": "R-CEL-8852019", "name": "MET bound PI3K generates PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10543881", "catalyst" ] ], "additional_components": [ "G5EDJ4", "WBGene00004928", "Q9XVQ7", "WBGene00008711", "P29355", "WBGene00004774", "G5EDP9", "WBGene00000001", "Q94125", "WBGene00000090" ] }, "reaction_10532954": { "compartment": "compartment_876", "id": "reaction_10532954", "reactome": "R-CEL-1306972", "name": "RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10512175", "species_29438" ], "products": [ "species_29420", "species_10511481" ], "modifiers": [ [ "species_10532951", "catalyst" ] ], "additional_components": [ "species_29420", "P22981", "WBGene00002335", "species_29438", "P22981", "WBGene00002335", "P29355", "WBGene00004774", "Q9N5D3", "WBGene00004947" ] }, "reaction_10532961": { "compartment": "compartment_876", "id": "reaction_10532961", "reactome": "R-CEL-1306979", "name": "PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10532958", "catalyst" ] ], "additional_components": [ "G5EDP9", "WBGene00000001", "Q94125", "WBGene00000090" ] }, "reaction_10532945": { "compartment": "compartment_876", "id": "reaction_10532945", "reactome": "R-CEL-1306957", "name": "PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10532942", "catalyst" ] ], "additional_components": [ "Q94125", "WBGene00000090", "G5EDP9", "WBGene00000001", "P29355", "WBGene00004774", "G5EDJ4", "WBGene00004928" ] }, "reaction_10532947": { "compartment": "compartment_70101", "id": "reaction_10532947", "reactome": "R-CEL-1306965", "name": "Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR.", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10506892", "species_10532938" ], "products": [ "species_10532942" ], "modifiers": [], "additional_components": [ "G5EDP9", "WBGene00000001", "Q94125", "WBGene00000090", "P29355", "WBGene00004774", "G5EDJ4", "WBGene00004928", "Q94125", "WBGene00000090", "G5EDP9", "WBGene00000001", "P29355", "WBGene00004774", "G5EDJ4", "WBGene00004928" ] }, "reaction_10532507": { "compartment": "compartment_876", "id": "reaction_10532507", "reactome": "R-CEL-1250462", "name": "PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10532504", "catalyst" ] ], "additional_components": [ "G5EDP9", "WBGene00000001", "Q94125", "WBGene00000090" ] }, "reaction_10572739": { "compartment": "compartment_70101", "id": "reaction_10572739", "reactome": "R-CEL-9652264", "name": "ERBB2 binds TKIs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9652360", "species_10538183" ], "products": [ "species_10572737" ], "modifiers": [], "additional_components": [ "P24348", "WBGene00002299", "O02108", "WBGene00021097", "Q18688", "WBGene00000915", "O02108", "WBGene00021097", "Q18688", "WBGene00000915", "P24348", "WBGene00002299" ] }, "reaction_10538193": { "compartment": "compartment_70101", "id": "reaction_10538193", "reactome": "R-CEL-1918095", "name": "CUL5 mediates ubiquitination of ERBB2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502375", "species_10538183" ], "products": [ "species_10538190" ], "modifiers": [ [ "species_10530998", "catalyst" ] ], "additional_components": [ "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "P24348", "WBGene00002299", "O02108", "WBGene00021097", "Q18688", "WBGene00000915", "P24348", "WBGene00002299", "O02108", "WBGene00021097", "Q18688", "WBGene00000915", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "WBGene00000840" ] }, "reaction_10538188": { "compartment": "compartment_70101", "id": "reaction_10538188", "reactome": "R-CEL-1918092", "name": "CHIP (STUB1) mediates ubiquitination of ERBB2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502375", "species_10538183" ], "products": [ "species_10538185" ], "modifiers": [ [ "species_10530864", "catalyst" ] ], "additional_components": [ "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "P24348", "WBGene00002299", "O02108", "WBGene00021097", "Q18688", "WBGene00000915", "P24348", "WBGene00002299", "O02108", "WBGene00021097", "Q18688", "WBGene00000915", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "WBGene00000500" ] }, "reaction_10512456": { "compartment": "compartment_984", "id": "reaction_10512456", "reactome": "R-CEL-186785", "name": "PDGF-AA clevage by Furin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10512452" ], "products": [ "species_10512392", "species_10512454" ], "modifiers": [ [ "species_10510315", "catalyst" ] ], "additional_components": [ "Q9N413", "WBGene00004249", "Q9N413", "WBGene00004249", "WBGene00004249", "WBGene00002232" ] }, "reaction_10520337": { "compartment": "compartment_70101", "id": "reaction_10520337", "reactome": "R-CEL-382058", "name": "Nck binds to the active PDGF receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10518510", "species_10512404" ], "products": [ "species_10520335" ], "modifiers": [], "additional_components": [ "WBGene00006410", "Q9N413", "WBGene00004249", "G5EGT9", "WBGene00003007", "A0A1I6CMA1", "WBGene00020678", "Q9N413", "WBGene00004249", "G5EGT9", "WBGene00003007", "A0A1I6CMA1", "WBGene00020678", "Q95PX0", "WBGene00006410" ] }, "reaction_10512466": { "compartment": "compartment_70101", "id": "reaction_10512466", "reactome": "R-CEL-186800", "name": "PI3K catalyses the phosphorylation of PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10512444", "catalyst" ] ], "additional_components": [ "Q9N413", "WBGene00004249", "G5EGT9", "WBGene00003007", "A0A1I6CMA1", "WBGene00020678", "G5EDP9", "WBGene00000001", "Q94125", "WBGene00000090" ] }, "reaction_10535202": { "compartment": "compartment_876", "id": "reaction_10535202", "reactome": "R-CEL-1524186", "name": "Phosphorylation of PLCgamma by PDGFR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10512408" ], "products": [ "species_10535197", "species_29370" ], "modifiers": [ [ "species_10512408", "catalyst" ] ], "additional_components": [ "Q9N413", "WBGene00004249", "G5EGT9", "WBGene00003007", "A0A1I6CMA1", "WBGene00020678", "Q22070", "WBGene00004038", "Q22070", "WBGene00004038", "Q9N413", "WBGene00004249", "G5EGT9", "WBGene00003007", "A0A1I6CMA1", "WBGene00020678", "Q9N413", "WBGene00004249", "G5EGT9", "WBGene00003007", "A0A1I6CMA1", "WBGene00020678", "Q22070", "WBGene00004038" ] }, "reaction_10519939": { "compartment": "compartment_70101", "id": "reaction_10519939", "reactome": "R-CEL-380782", "name": "STAT binds to the active receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10519935", "species_10512404" ], "products": [ "species_10519937" ], "modifiers": [], "additional_components": [ "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9N413", "WBGene00004249", "G5EGT9", "WBGene00003007", "A0A1I6CMA1", "WBGene00020678", "Q9N413", "WBGene00004249", "G5EGT9", "WBGene00003007", "A0A1I6CMA1", "WBGene00020678", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251" ] }, "reaction_10512484": { "compartment": "compartment_876", "id": "reaction_10512484", "reactome": "R-CEL-186819", "name": "SH2 domain of Src binds to the active receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10512404", "species_10512480" ], "products": [ "species_10512482" ], "modifiers": [], "additional_components": [ "Q9N413", "WBGene00004249", "G5EGT9", "WBGene00003007", "A0A1I6CMA1", "WBGene00020678", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q9N413", "WBGene00004249", "G5EGT9", "WBGene00003007", "A0A1I6CMA1", "WBGene00020678" ] }, "reaction_10512488": { "compartment": "compartment_70101", "id": "reaction_10512488", "reactome": "R-CEL-186826", "name": "GRB2:SOS1 complex binds to the active receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10506878", "species_10512404" ], "products": [ "species_10512486" ], "modifiers": [], "additional_components": [ "P29355", "WBGene00004774", "Q9N5D3", "WBGene00004947", "Q9N413", "WBGene00004249", "G5EGT9", "WBGene00003007", "A0A1I6CMA1", "WBGene00020678", "Q9N413", "WBGene00004249", "G5EGT9", "WBGene00003007", "A0A1I6CMA1", "WBGene00020678", "P29355", "WBGene00004774", "Q9N5D3", "WBGene00004947" ] }, "reaction_10512410": { "compartment": "compartment_876", "id": "reaction_10512410", "reactome": "R-CEL-186765", "name": "PLC-gamma binds to the active receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10512406", "species_10512404" ], "products": [ "species_10512408" ], "modifiers": [], "additional_components": [ "WBGene00004038", "Q9N413", "WBGene00004249", "G5EGT9", "WBGene00003007", "A0A1I6CMA1", "WBGene00020678", "Q9N413", "WBGene00004249", "G5EGT9", "WBGene00003007", "A0A1I6CMA1", "WBGene00020678", "Q22070", "WBGene00004038" ] }, "reaction_10512491": { "compartment": "compartment_70101", "id": "reaction_10512491", "reactome": "R-CEL-186834", "name": "SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10512175", "species_29438" ], "products": [ "species_29420", "species_10511481" ], "modifiers": [ [ "species_10512486", "catalyst" ] ], "additional_components": [ "species_29420", "P22981", "WBGene00002335", "species_29438", "P22981", "WBGene00002335", "Q9N413", "WBGene00004249", "G5EGT9", "WBGene00003007", "A0A1I6CMA1", "WBGene00020678", "P29355", "WBGene00004774", "Q9N5D3", "WBGene00004947" ] }, "reaction_10519901": { "compartment": "compartment_70101", "id": "reaction_10519901", "reactome": "R-CEL-380780", "name": "Activation of Src", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10512482" ], "products": [ "species_10519898", "species_29370" ], "modifiers": [ [ "species_10512482", "catalyst" ] ], "additional_components": [ "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q9N413", "WBGene00004249", "G5EGT9", "WBGene00003007", "A0A1I6CMA1", "WBGene00020678", "Q9N413", "WBGene00004249", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "G5EGT9", "WBGene00003007", "A0A1I6CMA1", "WBGene00020678", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q9N413", "WBGene00004249", "G5EGT9", "WBGene00003007", "A0A1I6CMA1", "WBGene00020678" ] }, "reaction_10512446": { "compartment": "compartment_70101", "id": "reaction_10512446", "reactome": "R-CEL-186780", "name": "PI3-kinase binds to the active receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10506892", "species_10512404" ], "products": [ "species_10512444" ], "modifiers": [], "additional_components": [ "G5EDP9", "WBGene00000001", "Q94125", "WBGene00000090", "Q9N413", "WBGene00004249", "G5EGT9", "WBGene00003007", "A0A1I6CMA1", "WBGene00020678", "Q9N413", "WBGene00004249", "G5EGT9", "WBGene00003007", "A0A1I6CMA1", "WBGene00020678", "G5EDP9", "WBGene00000001", "Q94125", "WBGene00000090" ] }, "reaction_10535199": { "compartment": "compartment_876", "id": "reaction_10535199", "reactome": "R-CEL-1524182", "name": "Activated PLC gamma dissociates from the PDGF receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10535197" ], "products": [ "species_10512404", "species_10515233" ], "modifiers": [], "additional_components": [ "Q22070", "WBGene00004038", "Q9N413", "WBGene00004249", "G5EGT9", "WBGene00003007", "A0A1I6CMA1", "WBGene00020678", "Q9N413", "WBGene00004249", "G5EGT9", "WBGene00003007", "A0A1I6CMA1", "WBGene00020678", "WBGene00004038" ] }, "reaction_10520319": { "compartment": "compartment_70101", "id": "reaction_10520319", "reactome": "R-CEL-382056", "name": "Crk binds to the active PDGF receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10520269", "species_10512404" ], "products": [ "species_10520271" ], "modifiers": [], "additional_components": [ "Q9NHC3", "WBGene00000416", "Q95XA9", "WBGene00021238", "Q9N413", "WBGene00004249", "G5EGT9", "WBGene00003007", "A0A1I6CMA1", "WBGene00020678", "Q9N413", "WBGene00004249", "G5EGT9", "WBGene00003007", "A0A1I6CMA1", "WBGene00020678", "Q9NHC3", "WBGene00000416", "Q95XA9", "WBGene00021238" ] }, "reaction_10573065": { "compartment": "compartment_876", "id": "reaction_10573065", "reactome": "R-CEL-9674093", "name": "PDGFRs bind type I TKI", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10520554", "species_9674075" ], "products": [ "species_10520559" ], "modifiers": [], "additional_components": [ "Q9N413", "WBGene00004249", "A0A1I6CMA1", "WBGene00020678", "G5EGT9", "WBGene00003007", "Q9N413", "WBGene00004249", "A0A1I6CMA1", "WBGene00020678", "G5EGT9", "WBGene00003007" ] }, "reaction_10573067": { "compartment": "compartment_876", "id": "reaction_10573067", "reactome": "R-CEL-9674095", "name": "PDGFRs bind type II TKI", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9674079", "species_10512424" ], "products": [ "species_10512436" ], "modifiers": [], "additional_components": [ "A0A1I6CMA1", "WBGene00020678", "G5EGT9", "WBGene00003007", "A0A1I6CMA1", "WBGene00020678", "G5EGT9", "WBGene00003007" ] }, "reaction_10520333": { "compartment": "compartment_984", "id": "reaction_10520333", "reactome": "R-CEL-382057", "name": "Release of novel PDGFs as latent factors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10520321" ], "products": [ "species_10520331" ], "modifiers": [], "additional_components": [ "Q9N413", "WBGene00004249", "Q9N413", "WBGene00004249" ] }, "reaction_10566190": { "compartment": "compartment_984", "id": "reaction_10566190", "reactome": "R-CEL-8865275", "name": "PDGF-BB clevage by Furin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10520297" ], "products": [ "species_10512398", "species_10566186" ], "modifiers": [ [ "species_10510315", "catalyst" ] ], "additional_components": [ "Q9N413", "WBGene00004249", "Q9N413", "WBGene00004249", "WBGene00004249", "WBGene00002232" ] }, "reaction_10512463": { "compartment": "compartment_70101", "id": "reaction_10512463", "reactome": "R-CEL-186786", "name": "Autophosphorylation of PDGF beta receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10512458", "species_113592" ], "products": [ "species_10512460", "species_29370" ], "modifiers": [ [ "species_10512458", "catalyst" ] ], "additional_components": [ "A0A1I6CMA1", "WBGene00020678", "G5EGT9", "WBGene00003007", "Q9N413", "WBGene00004249", "G5EGT9", "WBGene00003007", "A0A1I6CMA1", "WBGene00020678", "Q9N413", "WBGene00004249", "A0A1I6CMA1", "WBGene00020678", "G5EGT9", "WBGene00003007", "Q9N413", "WBGene00004249" ] }, "reaction_10566192": { "compartment": "compartment_984", "id": "reaction_10566192", "reactome": "R-CEL-8865276", "name": "PDGF-AB clevage by Furin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10520299" ], "products": [ "species_10566186", "species_10512454", "species_10512400" ], "modifiers": [ [ "species_10510315", "catalyst" ] ], "additional_components": [ "Q9N413", "WBGene00004249", "WBGene00004249", "WBGene00004249", "Q9N413", "WBGene00004249", "WBGene00002232" ] }, "reaction_10520561": { "compartment": "compartment_70101", "id": "reaction_10520561", "reactome": "R-CEL-389083", "name": "Autophosphorylation of PDGF alpha receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10520554", "species_113592" ], "products": [ "species_10520556", "species_29370" ], "modifiers": [ [ "species_10520554", "catalyst" ], [ "species_10520559", "inhibitor" ] ], "additional_components": [ "Q9N413", "WBGene00004249", "A0A1I6CMA1", "WBGene00020678", "G5EGT9", "WBGene00003007", "Q9N413", "WBGene00004249", "G5EGT9", "WBGene00003007", "A0A1I6CMA1", "WBGene00020678", "Q9N413", "WBGene00004249", "A0A1I6CMA1", "WBGene00020678", "G5EGT9", "WBGene00003007", "Q9N413", "WBGene00004249", "A0A1I6CMA1", "WBGene00020678", "G5EGT9", "WBGene00003007" ] }, "reaction_10520311": { "compartment": "compartment_20699", "id": "reaction_10520311", "reactome": "R-CEL-382053", "name": "Translocation of PDGF from ER to Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10520293" ], "products": [ "species_10520309" ], "modifiers": [], "additional_components": [ "Q9N413", "WBGene00004249", "Q9N413", "WBGene00004249" ] }, "reaction_10512440": { "compartment": "compartment_876", "id": "reaction_10512440", "reactome": "R-CEL-186773", "name": "PDGF dimer binds two receptors simultaneously", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10512424", "species_10512402" ], "products": [ "species_10512434" ], "modifiers": [ [ "species_10512438", "inhibitor" ], [ "species_10512436", "inhibitor" ] ], "additional_components": [ "A0A1I6CMA1", "WBGene00020678", "G5EGT9", "WBGene00003007", "Q9N413", "WBGene00004249", "A0A1I6CMA1", "WBGene00020678", "G5EGT9", "WBGene00003007", "Q9N413", "WBGene00004249", "A0A1I6CMA1", "WBGene00020678", "G5EGT9", "WBGene00003007", "A0A1I6CMA1", "WBGene00020678", "G5EGT9", "WBGene00003007" ] }, "reaction_10520571": { "compartment": "compartment_70101", "id": "reaction_10520571", "reactome": "R-CEL-389086", "name": "Autophosphorylation of PDGF alpha/beta receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10520566" ], "products": [ "species_29370", "species_10520568" ], "modifiers": [ [ "species_10520566", "catalyst" ] ], "additional_components": [ "Q9N413", "WBGene00004249", "A0A1I6CMA1", "WBGene00020678", "G5EGT9", "WBGene00003007", "Q9N413", "WBGene00004249", "G5EGT9", "WBGene00003007", "A0A1I6CMA1", "WBGene00020678", "Q9N413", "WBGene00004249", "A0A1I6CMA1", "WBGene00020678", "G5EGT9", "WBGene00003007" ] }, "reaction_10520317": { "compartment": "compartment_984", "id": "reaction_10520317", "reactome": "R-CEL-382054", "name": "PDGF binds to extracellular matrix proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10512396", "species_10520313" ], "products": [ "species_10520315" ], "modifiers": [], "additional_components": [ "WBGene00004249", "Q9N4U2", "WBGene00000647", "O76368", "WBGene00000674", "Q09457", "WBGene00000251", "P17140", "WBGene00002280", "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689", "CHEBI:18137", "CHEBI:17421", "Q9N4U2", "WBGene00000647", "O76368", "WBGene00000674", "Q09457", "WBGene00000251", "P17140", "WBGene00002280", "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689", "CHEBI:18137", "CHEBI:17421", "Q9N413", "WBGene00004249" ] }, "reaction_10533137": { "compartment": "compartment_876", "id": "reaction_10533137", "reactome": "R-CEL-1433423", "name": "PTP-RO interacts with p-c-Kit complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10533133", "species_10516216" ], "products": [ "species_10533135" ], "modifiers": [], "additional_components": [ "G5EC69", "WBGene00011755", "Q20019", "WBGene00011755", "Q21522", "WBGene00011755", "A0A1I6CMA1", "WBGene00020678", "G5EGT9", "WBGene00003007", "A0A1I6CMA1", "WBGene00020678", "G5EGT9", "WBGene00003007", "G5EC69", "WBGene00011755", "Q20019", "WBGene00011755", "Q21522", "WBGene00011755" ] }, "reaction_10573104": { "compartment": "compartment_876", "id": "reaction_10573104", "reactome": "R-CEL-9681375", "name": "KIT binds ripretinib", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10516216", "species_9674322" ], "products": [ "species_10573102" ], "modifiers": [], "additional_components": [ "A0A1I6CMA1", "WBGene00020678", "G5EGT9", "WBGene00003007", "A0A1I6CMA1", "WBGene00020678", "G5EGT9", "WBGene00003007" ] }, "reaction_10533140": { "compartment": "compartment_876", "id": "reaction_10533140", "reactome": "R-CEL-1433471", "name": "Activation of RAS by p-KIT bound SOS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10512175", "species_29438" ], "products": [ "species_29420", "species_10511481" ], "modifiers": [ [ "species_10516244", "catalyst" ] ], "additional_components": [ "species_29420", "P22981", "WBGene00002335", "species_29438", "P22981", "WBGene00002335", "A0A1I6CMA1", "WBGene00020678", "G5EGT9", "WBGene00003007", "P29355", "WBGene00004774", "Q9N5D3", "WBGene00004947" ] }, "reaction_10533155": { "compartment": "compartment_876", "id": "reaction_10533155", "reactome": "R-CEL-1433508", "name": "PKC alpha interacts with and phosphorylates KIT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10516216", "species_10509044" ], "products": [ "species_29370", "species_10533152" ], "modifiers": [ [ "species_10509044", "catalyst" ] ], "additional_components": [ "A0A1I6CMA1", "WBGene00020678", "G5EGT9", "WBGene00003007", "WBGene00004033", "P90980", "WBGene00004033", "A0A1I6CMA1", "WBGene00020678", "G5EGT9", "WBGene00003007", "WBGene00004033" ] }, "reaction_10516248": { "compartment": "compartment_876", "id": "reaction_10516248", "reactome": "R-CEL-205244", "name": "Recruitment of CBL to KIT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10512267", "species_10516244" ], "products": [ "species_10516246" ], "modifiers": [], "additional_components": [ "WBGene00004829", "A0A1I6CMA1", "WBGene00020678", "G5EGT9", "WBGene00003007", "P29355", "WBGene00004774", "Q9N5D3", "WBGene00004947", "A0A1I6CMA1", "WBGene00020678", "G5EGT9", "WBGene00003007", "P29355", "WBGene00004774", "Q9N5D3", "WBGene00004947", "Q19019", "WBGene00004829" ] }, "reaction_10533180": { "compartment": "compartment_876", "id": "reaction_10533180", "reactome": "R-CEL-1433514", "name": "Synthesis of PIP3 from PIP2 by PI3K", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10533177", "catalyst" ] ], "additional_components": [ "A0A1I6CMA1", "WBGene00020678", "G5EGT9", "WBGene00003007", "Q9N3S5", "WBGene00021635", "G5EE56", "WBGene00005077", "P29355", "WBGene00004774", "G5EDJ4", "WBGene00004928", "G5EDP9", "WBGene00000001", "Q94125", "WBGene00000090" ] }, "reaction_10533119": { "compartment": "compartment_70101", "id": "reaction_10533119", "reactome": "R-CEL-1433415", "name": "Activation of RAC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10520575", "species_29438" ], "products": [ "species_29420", "species_10509457" ], "modifiers": [ [ "species_10533116", "catalyst" ] ], "additional_components": [ "species_29420", "Q03206", "ced-10", "species_29438", "Q03206", "ced-10", "Q45FX5", "WBGene00006887", "species_179838" ] }, "reaction_10573054": { "compartment": "compartment_876", "id": "reaction_10573054", "reactome": "R-CEL-9669854", "name": "KIT binds type II TKIs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9669722", "species_10516216" ], "products": [ "species_10573052" ], "modifiers": [], "additional_components": [ "A0A1I6CMA1", "WBGene00020678", "G5EGT9", "WBGene00003007", "A0A1I6CMA1", "WBGene00020678", "G5EGT9", "WBGene00003007" ] }, "reaction_10506848": { "compartment": "compartment_17940", "id": "reaction_10506848", "reactome": "R-CEL-74723", "name": "Endosome acidification", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106" ], "products": [ "species_74722" ], "modifiers": [ [ "species_10506845", "catalyst" ] ], "additional_components": [ "G5EGP4", "WBGene00006915", "P30628", "WBGene00006768", "B2MZD0", "WBGene00006916", "G5EEK9", "WBGene00006914", "C0HLB3", "WBGene00006911", "C0HLB4", "WBGene00006912", "G5EDB8", "WBGene00006913", "Q95YD5", "WBGene00016258", "Q20591", "WBGene00009882", "Q9XXU9", "WBGene00006920", "Q22494", "WBGene00020507", "Q23680", "WBGene00006918", "P34462", "WBGene00010130", "Q9XW92", "WBGene00013025", "Q19626", "WBGene00006921", "Q9N5A0", "WBGene00004959", "Q95X44", "WBGene00006917", "P91303", "WBGene00006919", "Q9TYW1", "WBGene00021952" ] }, "reaction_10506866": { "compartment": "compartment_876", "id": "reaction_10506866", "reactome": "R-CEL-74734", "name": "Re-integration of insulin receptor into plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10506864" ], "products": [ "species_10506690" ], "modifiers": [], "additional_components": [ "Q968Y9", "WBGene00000898", "Q968Y9", "WBGene00000898" ] }, "reaction_10551244": { "compartment": "compartment_171062", "id": "reaction_10551244", "reactome": "R-CEL-5252133", "name": "ATP6AP1 binds V-ATPase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10506843", "species_10506838" ], "products": [ "species_10506845" ], "modifiers": [], "additional_components": [ "WBGene00021952", "G5EGP4", "WBGene00006915", "P30628", "WBGene00006768", "B2MZD0", "WBGene00006916", "G5EEK9", "WBGene00006914", "C0HLB3", "WBGene00006911", "C0HLB4", "WBGene00006912", "G5EDB8", "WBGene00006913", "Q95YD5", "WBGene00016258", "Q20591", "WBGene00009882", "Q9XXU9", "WBGene00006920", "Q22494", "WBGene00020507", "Q23680", "WBGene00006918", "P34462", "WBGene00010130", "Q9XW92", "WBGene00013025", "Q19626", "WBGene00006921", "Q9N5A0", "WBGene00004959", "Q95X44", "WBGene00006917", "P91303", "WBGene00006919", "G5EGP4", "WBGene00006915", "P30628", "WBGene00006768", "B2MZD0", "WBGene00006916", "G5EEK9", "WBGene00006914", "C0HLB3", "WBGene00006911", "C0HLB4", "WBGene00006912", "G5EDB8", "WBGene00006913", "Q95YD5", "WBGene00016258", "Q20591", "WBGene00009882", "Q9XXU9", "WBGene00006920", "Q22494", "WBGene00020507", "Q23680", "WBGene00006918", "P34462", "WBGene00010130", "Q9XW92", "WBGene00013025", "Q19626", "WBGene00006921", "Q9N5A0", "WBGene00004959", "Q95X44", "WBGene00006917", "P91303", "WBGene00006919", "Q9TYW1", "WBGene00021952" ] }, "reaction_10555984": { "compartment": "compartment_70101", "id": "reaction_10555984", "reactome": "R-CEL-5687107", "name": "MAPK4,6 translocate to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10555976" ], "products": [ "species_10555982" ], "modifiers": [], "additional_components": [ "P39745", "WBGene00003401", "P39745", "WBGene00003401" ] }, "reaction_10555986": { "compartment": "compartment_7660", "id": "reaction_10555986", "reactome": "R-CEL-5687109", "name": "MAPK4,6 translocate to the cytoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10555982" ], "products": [ "species_10555976" ], "modifiers": [ [ "species_10511186", "catalyst" ] ], "additional_components": [ "P39745", "WBGene00003401", "P39745", "WBGene00003401", "WBGene00002078" ] }, "reaction_10520692": { "compartment": "compartment_70101", "id": "reaction_10520692", "reactome": "R-CEL-389788", "name": "Activation of PAKs by RAC1 and CDC42", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10520686", "species_10520664" ], "products": [ "species_10520690", "species_10520688" ], "modifiers": [], "additional_components": [ "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "species_29438", "Q03206", "ced-10", "Q05062", "WBGene00000390", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "species_29438", "Q03206", "ced-10", "Q05062", "WBGene00000390", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911" ] }, "reaction_10555989": { "compartment": "compartment_70101", "id": "reaction_10555989", "reactome": "R-CEL-5687112", "name": "MAPK6 is degraded by the 26S proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10555953" ], "products": [ "species_10502375" ], "modifiers": [ [ "species_10502572", "catalyst" ] ], "additional_components": [ "WBGene00003401", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "P91477", "WBGene00003950", "Q95PZ7", "WBGene00013435", "Q18115", "WBGene00004459", "O62102", "WBGene00003948", "O17071", "WBGene00004504", "Q10920", "WBGene00016623", "P34286", "WBGene00003952", "Q9XTT9", "WBGene00004506", "Q23449", "WBGene00004468", "Q95005", "WBGene00003925", "P46502", "WBGene00004503", "O61792", "WBGene00004464", "O17586", "WBGene00003922", "O76371", "WBGene00004505", "Q20585", "WBGene00004463", "Q95008", "WBGene00003926", "Q18787", "WBGene00004501", "Q20058", "WBGene00009445", "Q9N599", "WBGene00003924", "O16368", "WBGene00004502", "O61742", "WBGene00004466", "Q09583", "WBGene00003928", "Q966I8", "WBGene00003947", "Q04908", "WBGene00004460", "Q9XUV0", "WBGene00003951", "Q27488", "WBGene00003923", "Q9GZH5", "WBGene00004458", "O44156", "WBGene00003927", "Q22253", "WBGene00004465", "O76577", "WBGene00004467", "P90868", "WBGene00003953", "Q19324", "WBGene00004461", "Q17971", "WBGene00007588", "Q23237", "WBGene00003949", "Q20938", "WBGene00004462" ] }, "reaction_10556932": { "compartment": "compartment_7660", "id": "reaction_10556932", "reactome": "R-CEL-5692749", "name": "CDC14A,B bind MAPK6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10556926", "species_10556924" ], "products": [ "species_10556930" ], "modifiers": [], "additional_components": [ "WBGene00000383", "WBGene00003401", "P39745", "WBGene00003401", "P81299", "WBGene00000383" ] }, "reaction_10556937": { "compartment": "compartment_7660", "id": "reaction_10556937", "reactome": "R-CEL-5692754", "name": "CDC14A,B dephosphorylate p-3S,T MAPK6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10556930" ], "products": [ "species_113550", "species_10556934" ], "modifiers": [ [ "species_10556930", "catalyst" ] ], "additional_components": [ "P39745", "WBGene00003401", "P81299", "WBGene00000383", "P39745", "WBGene00003401", "P81299", "WBGene00000383", "P39745", "WBGene00003401", "P81299", "WBGene00000383" ] }, "reaction_10555993": { "compartment": "compartment_70101", "id": "reaction_10555993", "reactome": "R-CEL-5687126", "name": "p-S215 FOXO3 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10555974" ], "products": [ "species_10555970" ], "modifiers": [], "additional_components": [ "WBGene00000912", "WBGene00000912" ] }, "reaction_10555963": { "compartment": "compartment_70101", "id": "reaction_10555963", "reactome": "R-CEL-5687086", "name": "PAK1,2,3 phosphorylates MAPK6,4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10555955" ], "products": [ "species_29370", "species_10555958" ], "modifiers": [ [ "species_10521284", "catalyst" ] ], "additional_components": [ "WBGene00003401", "WBGene00003401", "Q17850", "WBGene00003911", "G5EGQ3", "WBGene00003144" ] }, "reaction_10556940": { "compartment": "compartment_7660", "id": "reaction_10556940", "reactome": "R-CEL-5692755", "name": "CDK1 phosphorylates MAPK6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10555980" ], "products": [ "species_113582", "species_10556924" ], "modifiers": [ [ "species_10511154", "catalyst" ] ], "additional_components": [ "WBGene00003401", "WBGene00003401", "WBGene00000405" ] }, "reaction_10555185": { "compartment": "compartment_876", "id": "reaction_10555185", "reactome": "R-CEL-5675194", "name": "Activated MAPK phosphorylates RAF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10554998" ], "products": [ "species_10555183", "species_29370" ], "modifiers": [ [ "species_10555165", "catalyst" ] ], "additional_components": [ "WBGene00003030", "WBGene00003030", "P39745", "WBGene00003401" ] }, "reaction_10555193": { "compartment": "compartment_876", "id": "reaction_10555193", "reactome": "R-CEL-5675198", "name": "Activated MAPKs phosphorylate BRAF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10555000" ], "products": [ "species_29370", "species_10555191" ], "modifiers": [ [ "species_10555165", "catalyst" ] ], "additional_components": [ "WBGene00003030", "WBGene00003030", "P39745", "WBGene00003401" ] }, "reaction_10555176": { "compartment": "compartment_70101", "id": "reaction_10555176", "reactome": "R-CEL-5674496", "name": "Activated MAPKs phosphorylate MAP2K1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10555059" ], "products": [ "species_29370", "species_10555173" ], "modifiers": [ [ "species_10555165", "catalyst" ] ], "additional_components": [ "Q10664", "WBGene00003186", "Q10664", "WBGene00003186", "P39745", "WBGene00003401" ] }, "reaction_10555140": { "compartment": "compartment_20699", "id": "reaction_10555140", "reactome": "R-CEL-5674140", "name": "PAQR3 binds inactive RAFs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10554946", "species_10555136" ], "products": [ "species_10555138" ], "modifiers": [], "additional_components": [ "WBGene00003030", "WBGene00013457", "Q9U1V1", "WBGene00013457", "Q07292", "WBGene00003030" ] }, "reaction_10555236": { "compartment": "compartment_876", "id": "reaction_10555236", "reactome": "R-CEL-5675431", "name": "PP2A dephosphorylates RAF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10555230", "species_29356" ], "products": [ "species_29372", "species_10555234" ], "modifiers": [ [ "species_10513555", "catalyst" ], [ "species_10555183", "catalyst" ] ], "additional_components": [ "Q07292", "WBGene00003030", "species_29438", "P22981", "WBGene00002335", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "Q07292", "WBGene00003030", "species_29438", "P22981", "WBGene00002335", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "WBGene00003030" ] }, "reaction_10555110": { "compartment": "compartment_876", "id": "reaction_10555110", "reactome": "R-CEL-5674022", "name": "BRAP autoubiquitinates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10555100", "species_10502375" ], "products": [ "species_10555107" ], "modifiers": [ [ "species_10555100", "catalyst" ] ], "additional_components": [ "species_29438", "P22981", "WBGene00002335", "Q95QN6", "WBGene00017144", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "Q95QN6", "WBGene00017144", "species_29438", "P22981", "WBGene00002335", "species_29438", "P22981", "WBGene00002335", "Q95QN6", "WBGene00017144" ] }, "reaction_10566377": { "compartment": "compartment_70101", "id": "reaction_10566377", "reactome": "R-CEL-8867654", "name": "PTPN3 binds p-T183,Y185 MAPK12", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10525306", "species_10566373" ], "products": [ "species_10566375" ], "modifiers": [], "additional_components": [ "Q17446", "WBGene00004055", "Q8MXI4", "WBGene00004056", "WBGene00004213", "P28191", "WBGene00004213", "Q17446", "WBGene00004055", "Q8MXI4", "WBGene00004056" ] }, "reaction_10566488": { "compartment": "compartment_70101", "id": "reaction_10566488", "reactome": "R-CEL-8868118", "name": "MAPK12 phosphorylates PTPN3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10566375" ], "products": [ "species_29370", "species_10566485" ], "modifiers": [ [ "species_10566375", "catalyst" ] ], "additional_components": [ "P28191", "WBGene00004213", "Q17446", "WBGene00004055", "Q8MXI4", "WBGene00004056", "P28191", "WBGene00004213", "Q17446", "WBGene00004055", "Q8MXI4", "WBGene00004056", "P28191", "WBGene00004213", "Q17446", "WBGene00004055", "Q8MXI4", "WBGene00004056" ] }, "reaction_10555226": { "compartment": "compartment_876", "id": "reaction_10555226", "reactome": "R-CEL-5675417", "name": "PEBP1 binds activated RAF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10555049", "species_10555044" ], "products": [ "species_10555051" ], "modifiers": [], "additional_components": [ "WBGene00018218", "Q07292", "WBGene00003030", "species_29438", "P22981", "WBGene00002335", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "Q07292", "WBGene00003030", "species_29438", "P22981", "WBGene00002335", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "O16264", "WBGene00018218" ] }, "reaction_10555245": { "compartment": "compartment_876", "id": "reaction_10555245", "reactome": "R-CEL-5675433", "name": "PP5 dephosphorylates RAF1 S338", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10555044" ], "products": [ "species_10555230", "species_29372" ], "modifiers": [ [ "species_10555242", "catalyst" ] ], "additional_components": [ "Q07292", "WBGene00003030", "species_29438", "P22981", "WBGene00002335", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "Q07292", "WBGene00003030", "species_29438", "P22981", "WBGene00002335", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "WBGene00012665" ] }, "reaction_10566380": { "compartment": "compartment_70101", "id": "reaction_10566380", "reactome": "R-CEL-8867658", "name": "PTPN3 dephosphorylates MAPK12", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10566375" ], "products": [ "species_29372", "species_10566373", "species_10526147" ], "modifiers": [ [ "species_10566375", "catalyst" ] ], "additional_components": [ "P28191", "WBGene00004213", "Q17446", "WBGene00004055", "Q8MXI4", "WBGene00004056", "WBGene00004213", "Q8MXI4", "WBGene00004056", "Q17446", "WBGene00004055", "P28191", "WBGene00004213", "Q17446", "WBGene00004055", "Q8MXI4", "WBGene00004056" ] }, "reaction_10555102": { "compartment": "compartment_876", "id": "reaction_10555102", "reactome": "R-CEL-5674018", "name": "BRAP binds RAS:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10555098", "species_10511481" ], "products": [ "species_10555100" ], "modifiers": [], "additional_components": [ "WBGene00017144", "species_29438", "P22981", "WBGene00002335", "species_29438", "P22981", "WBGene00002335", "Q95QN6", "WBGene00017144" ] }, "reaction_10572703": { "compartment": "compartment_876", "id": "reaction_10572703", "reactome": "R-CEL-9649736", "name": "RAS intrinsic GTPase activity hydrolyzes GTP to GDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10511481" ], "products": [ "species_10512175" ], "modifiers": [ [ "species_10511481", "catalyst" ] ], "additional_components": [ "species_29438", "P22981", "WBGene00002335", "species_29420", "P22981", "WBGene00002335", "species_29438", "P22981", "WBGene00002335" ] }, "reaction_10572700": { "compartment": "compartment_876", "id": "reaction_10572700", "reactome": "R-CEL-9649735", "name": "Intrinsic nucleotide exchange on RAS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10512175", "species_29438" ], "products": [ "species_29420", "species_10511481" ], "modifiers": [], "additional_components": [ "species_29420", "P22981", "WBGene00002335", "species_29438", "P22981", "WBGene00002335" ] }, "reaction_10572741": { "compartment": "compartment_876", "id": "reaction_10572741", "reactome": "R-CEL-9653108", "name": "Raf dimer inhibitors bind RAF heterodimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9657579", "species_10554994" ], "products": [ "species_10555084" ], "modifiers": [], "additional_components": [ "Q07292", "WBGene00003030", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "species_29438", "P22981", "WBGene00002335", "Q07292", "WBGene00003030", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "species_29438", "P22981", "WBGene00002335" ] }, "reaction_10554964": { "compartment": "compartment_70101", "id": "reaction_10554964", "reactome": "R-CEL-5672960", "name": "YWHAB dimer dissociates from dephosphorylated RAF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10554962" ], "products": [ "species_10507067", "species_10554906" ], "modifiers": [], "additional_components": [ "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "Q07292", "WBGene00003030", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "WBGene00003030" ] }, "reaction_10554996": { "compartment": "compartment_876", "id": "reaction_10554996", "reactome": "R-CEL-5672966", "name": "RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10554906", "species_10554935" ], "products": [ "species_10554994" ], "modifiers": [], "additional_components": [ "WBGene00003030", "Q07292", "WBGene00003030", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "species_29438", "P22981", "WBGene00002335", "Q07292", "WBGene00003030", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "species_29438", "P22981", "WBGene00002335" ] }, "reaction_10554967": { "compartment": "compartment_70101", "id": "reaction_10554967", "reactome": "R-CEL-5672961", "name": "PP2A dephosphorylates inactive RAFs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10554954" ], "products": [ "species_29372", "species_10554962" ], "modifiers": [ [ "species_10513555", "catalyst" ] ], "additional_components": [ "Q07292", "WBGene00003030", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "Q07292", "WBGene00003030" ] }, "reaction_10572954": { "compartment": "compartment_876", "id": "reaction_10572954", "reactome": "R-CEL-9658445", "name": "MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10554954" ], "products": [ "species_29372", "species_10554962" ], "modifiers": [ [ "species_10572951", "catalyst" ] ], "additional_components": [ "Q07292", "WBGene00003030", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "Q07292", "WBGene00003030", "Q27497", "WBGene00001747", "P48727", "WBGene00001748", "Q22875", "WBGene00004929", "G5EGA7", "WBGene00004311", "species_29438" ] }, "reaction_10554956": { "compartment": "compartment_70101", "id": "reaction_10554956", "reactome": "R-CEL-5672951", "name": "Inactive RAFs bind YWHAB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10507067", "species_10554946" ], "products": [ "species_10554954" ], "modifiers": [], "additional_components": [ "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "WBGene00003030", "Q07292", "WBGene00003030", "P41932", "WBGene00003920", "Q20655", "WBGene00001502" ] }, "reaction_10554942": { "compartment": "compartment_876", "id": "reaction_10554942", "reactome": "R-CEL-5672950", "name": "\"Activator\" RAF:YWHAB dimer binds RAS:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10511481", "species_10554933" ], "products": [ "species_10554935" ], "modifiers": [ [ "species_10554940", "catalyst" ] ], "additional_components": [ "species_29438", "P22981", "WBGene00002335", "Q07292", "WBGene00003030", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "Q07292", "WBGene00003030", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "species_29438", "P22981", "WBGene00002335", "WBGene00004014" ] }, "reaction_10572966": { "compartment": "compartment_876", "id": "reaction_10572966", "reactome": "R-CEL-9660557", "name": "RAS:GTP binds RAL GDS proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10511486", "species_10572962" ], "products": [ "species_10572964" ], "modifiers": [], "additional_components": [ "WBGene00017891", "P22981", "WBGene00002335", "species_29438", "P22981", "WBGene00002335", "species_29438", "Q19852", "WBGene00017891" ] }, "reaction_10572576": { "compartment": "compartment_12045", "id": "reaction_10572576", "reactome": "R-CEL-9647977", "name": "ICMT methylates S-Farn RAS proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10572567", "species_71284" ], "products": [ "species_10572572", "species_71285" ], "modifiers": [ [ "species_10558332", "catalyst" ], [ "species_10572574", "inhibitor" ] ], "additional_components": [ "WBGene00002335", "WBGene00002335", "species_216785", "P91402", "WBGene00019710", "species_216785", "P91402", "WBGene00019710" ] }, "reaction_10572896": { "compartment": "compartment_876", "id": "reaction_10572896", "reactome": "R-CEL-9654521", "name": "Calmodulin dissociates KRAS4B from the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10549080" ], "products": [ "species_10572894" ], "modifiers": [], "additional_components": [ "species_74016", "Q11083", "WBGene00020378", "P04630", "WBGene00000285", "G5EF37", "WBGene00003934", "A0A2C9C3L3", "WBGene00020378", "Q18136", "WBGene00006861", "Q09665", "WBGene00006583", "O02159", "WBGene00020378", "G5EDZ8", "WBGene00000288", "Q94288", "WBGene00000287", "Q09980", "WBGene00017394", "O16305", "WBGene00000552", "G5EEG0", "WBGene00000286", "P22981", "WBGene00002335", "species_74016", "Q11083", "WBGene00020378", "P04630", "WBGene00000285", "G5EF37", "WBGene00003934", "A0A2C9C3L3", "WBGene00020378", "Q18136", "WBGene00006861", "Q09665", "WBGene00006583", "O02159", "WBGene00020378", "G5EDZ8", "WBGene00000288", "Q94288", "WBGene00000287", "Q09980", "WBGene00017394", "O16305", "WBGene00000552", "G5EEG0", "WBGene00000286", "P22981", "WBGene00002335" ] }, "reaction_10572610": { "compartment": "compartment_20699", "id": "reaction_10572610", "reactome": "R-CEL-9647982", "name": "S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10572572", "species_200993" ], "products": [ "species_76194", "species_10572592" ], "modifiers": [ [ "species_10572607", "catalyst" ] ], "additional_components": [ "WBGene00002335", "WBGene00002335", "Q9U204", "WBGene00013323", "Q9XWD7", "WBGene00012948" ] }, "reaction_10572612": { "compartment": "compartment_70101", "id": "reaction_10572612", "reactome": "R-CEL-9647987", "name": "FNTB inhibitors bind FNTA:FNTB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9653479", "species_10544771" ], "products": [ "species_10572587" ], "modifiers": [], "additional_components": [ "Q19752", "WBGene00006465", "O44501", "WBGene00019823", "Q19752", "WBGene00006465", "O44501", "WBGene00019823" ] }, "reaction_10572679": { "compartment": "compartment_12045", "id": "reaction_10572679", "reactome": "R-CEL-9647999", "name": "RCE1 cleaves S-Farn proRAS proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10572583" ], "products": [ "species_10572567" ], "modifiers": [ [ "species_10572676", "catalyst" ] ], "additional_components": [ "WBGene00002335", "WBGene00002335", "WBGene00001406" ] }, "reaction_10572902": { "compartment": "compartment_70101", "id": "reaction_10572902", "reactome": "R-CEL-9654523", "name": "ARL2:GTP bind PDE6D on KRAS4B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10572898", "species_10550993" ], "products": [ "species_10572900" ], "modifiers": [], "additional_components": [ "Q18268", "WBGene00003966", "species_74016", "Q11083", "WBGene00020378", "P04630", "WBGene00000285", "G5EF37", "WBGene00003934", "A0A2C9C3L3", "WBGene00020378", "Q18136", "WBGene00006861", "Q09665", "WBGene00006583", "O02159", "WBGene00020378", "G5EDZ8", "WBGene00000288", "Q94288", "WBGene00000287", "Q09980", "WBGene00017394", "O16305", "WBGene00000552", "G5EEG0", "WBGene00000286", "P22981", "WBGene00002335", "species_29438", "Q19705", "WBGene00001358", "species_29438", "Q19705", "WBGene00001358", "Q18268", "WBGene00003966", "species_74016", "Q11083", "WBGene00020378", "P04630", "WBGene00000285", "G5EF37", "WBGene00003934", "A0A2C9C3L3", "WBGene00020378", "Q18136", "WBGene00006861", "Q09665", "WBGene00006583", "O02159", "WBGene00020378", "G5EDZ8", "WBGene00000288", "Q94288", "WBGene00000287", "Q09980", "WBGene00017394", "O16305", "WBGene00000552", "G5EEG0", "WBGene00000286", "P22981", "WBGene00002335" ] }, "reaction_10572906": { "compartment": "compartment_70101", "id": "reaction_10572906", "reactome": "R-CEL-9654525", "name": "PDE6D binds S-Farn-Me KRAS4B:CALM:4 Ca2+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10572894", "species_10553585" ], "products": [ "species_10572898" ], "modifiers": [ [ "species_10572904", "inhibitor" ] ], "additional_components": [ "species_74016", "Q11083", "WBGene00020378", "P04630", "WBGene00000285", "G5EF37", "WBGene00003934", "A0A2C9C3L3", "WBGene00020378", "Q18136", "WBGene00006861", "Q09665", "WBGene00006583", "O02159", "WBGene00020378", "G5EDZ8", "WBGene00000288", "Q94288", "WBGene00000287", "Q09980", "WBGene00017394", "O16305", "WBGene00000552", "G5EEG0", "WBGene00000286", "P22981", "WBGene00002335", "WBGene00003966", "Q18268", "WBGene00003966", "species_74016", "Q11083", "WBGene00020378", "P04630", "WBGene00000285", "G5EF37", "WBGene00003934", "A0A2C9C3L3", "WBGene00020378", "Q18136", "WBGene00006861", "Q09665", "WBGene00006583", "O02159", "WBGene00020378", "G5EDZ8", "WBGene00000288", "Q94288", "WBGene00000287", "Q09980", "WBGene00017394", "O16305", "WBGene00000552", "G5EEG0", "WBGene00000286", "P22981", "WBGene00002335", "Q18268", "WBGene00003966" ] }, "reaction_10572589": { "compartment": "compartment_70101", "id": "reaction_10572589", "reactome": "R-CEL-9647978", "name": "pro-RAS proteins are farnesylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10572579", "species_2530486" ], "products": [ "species_111294", "species_10572583" ], "modifiers": [ [ "species_10544771", "catalyst" ], [ "species_10572587", "inhibitor" ] ], "additional_components": [ "WBGene00002335", "WBGene00002335", "Q19752", "WBGene00006465", "O44501", "WBGene00019823", "Q19752", "WBGene00006465", "O44501", "WBGene00019823" ] }, "reaction_10572909": { "compartment": "compartment_876", "id": "reaction_10572909", "reactome": "R-CEL-9654533", "name": "KRAS4B recycles to the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10572900" ], "products": [ "species_10511479", "species_10508995", "species_10550993", "species_10553585" ], "modifiers": [], "additional_components": [ "species_29438", "Q19705", "WBGene00001358", "Q18268", "WBGene00003966", "species_74016", "Q11083", "WBGene00020378", "P04630", "WBGene00000285", "G5EF37", "WBGene00003934", "A0A2C9C3L3", "WBGene00020378", "Q18136", "WBGene00006861", "Q09665", "WBGene00006583", "O02159", "WBGene00020378", "G5EDZ8", "WBGene00000288", "Q94288", "WBGene00000287", "Q09980", "WBGene00017394", "O16305", "WBGene00000552", "G5EEG0", "WBGene00000286", "P22981", "WBGene00002335", "WBGene00002335", "species_74016", "Q11083", "WBGene00020378", "P04630", "WBGene00000285", "G5EF37", "WBGene00003934", "A0A2C9C3L3", "WBGene00020378", "Q18136", "WBGene00006861", "Q09665", "WBGene00006583", "O02159", "WBGene00020378", "G5EDZ8", "WBGene00000288", "Q94288", "WBGene00000287", "Q09980", "WBGene00017394", "O16305", "WBGene00000552", "G5EEG0", "WBGene00000286", "species_29438", "Q19705", "WBGene00001358", "WBGene00003966" ] }, "reaction_10572753": { "compartment": "compartment_70101", "id": "reaction_10572753", "reactome": "R-CEL-9653503", "name": "KRAS4B is phosphorylated on serine 181", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10511479" ], "products": [ "species_29370", "species_10572744" ], "modifiers": [ [ "species_10572750", "catalyst" ] ], "additional_components": [ "WBGene00002335", "WBGene00002335", "species_112275", "P34722", "WBGene00006599", "H2KYN2", "WBGene00015650", "O76360", "WBGene00001173", "species_30991" ] }, "reaction_10572881": { "compartment": "compartment_876", "id": "reaction_10572881", "reactome": "R-CEL-9653585", "name": "S-Farn-Me KRAS4B binds calmodulin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10511479", "species_10508995" ], "products": [ "species_10549080" ], "modifiers": [ [ "species_10572744", "inhibitor" ] ], "additional_components": [ "WBGene00002335", "species_74016", "Q11083", "WBGene00020378", "P04630", "WBGene00000285", "G5EF37", "WBGene00003934", "A0A2C9C3L3", "WBGene00020378", "Q18136", "WBGene00006861", "Q09665", "WBGene00006583", "O02159", "WBGene00020378", "G5EDZ8", "WBGene00000288", "Q94288", "WBGene00000287", "Q09980", "WBGene00017394", "O16305", "WBGene00000552", "G5EEG0", "WBGene00000286", "species_74016", "Q11083", "WBGene00020378", "P04630", "WBGene00000285", "G5EF37", "WBGene00003934", "A0A2C9C3L3", "WBGene00020378", "Q18136", "WBGene00006861", "Q09665", "WBGene00006583", "O02159", "WBGene00020378", "G5EDZ8", "WBGene00000288", "Q94288", "WBGene00000287", "Q09980", "WBGene00017394", "O16305", "WBGene00000552", "G5EEG0", "WBGene00000286", "P22981", "WBGene00002335", "WBGene00002335" ] }, "reaction_10572598": { "compartment": "compartment_876", "id": "reaction_10572598", "reactome": "R-CEL-9647980", "name": "mature RAS proteins translocate to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10572592" ], "products": [ "species_10511477" ], "modifiers": [], "additional_components": [ "WBGene00002335", "WBGene00002335" ] }, "reaction_10572886": { "compartment": "compartment_17906", "id": "reaction_10572886", "reactome": "R-CEL-9653592", "name": "pS181-S-Farn-Me KRAS4B translocates to the outer mitochondrial membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10572744" ], "products": [ "species_10572884" ], "modifiers": [], "additional_components": [ "WBGene00002335", "WBGene00002335" ] }, "reaction_10572696": { "compartment": "compartment_12045", "id": "reaction_10572696", "reactome": "R-CEL-9649732", "name": "Mature S-Farn-Me KRAS4B translocates to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10572572" ], "products": [ "species_10511479" ], "modifiers": [], "additional_components": [ "WBGene00002335", "WBGene00002335" ] }, "reaction_10572666": { "compartment": "compartment_876", "id": "reaction_10572666", "reactome": "R-CEL-9647991", "name": "Palmostatin B binds RAS depalmitoylases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9647934", "species_10572662" ], "products": [ "species_10572664" ], "modifiers": [], "additional_components": [ "Q9XVA7", "WBGene00044003", "Q21221", "WBGene00045192", "Q5FC17", "WBGene00044003", "Q7JKU8", "WBGene00044003", "Q9BL52", "WBGene00044003", "A0A061ACY0", "WBGene00010564", "Q9XVA7", "WBGene00044003", "Q21221", "WBGene00045192", "Q5FC17", "WBGene00044003", "Q7JKU8", "WBGene00044003", "Q9BL52", "WBGene00044003", "A0A061ACY0", "WBGene00010564" ] }, "reaction_10572698": { "compartment": "compartment_876", "id": "reaction_10572698", "reactome": "R-CEL-9649733", "name": "mature p21 RAS binds GDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10511471", "species_29420" ], "products": [ "species_10512175" ], "modifiers": [], "additional_components": [ "WBGene00002335", "species_29420", "P22981", "WBGene00002335" ] }, "reaction_10572890": { "compartment": "compartment_17906", "id": "reaction_10572890", "reactome": "R-CEL-9653595", "name": "pS181-S-Farn-Me KRAS4B binds BCL2L1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10572884", "species_10528114" ], "products": [ "species_10572888" ], "modifiers": [], "additional_components": [ "WBGene00002335", "WBGene00000423", "P41958", "WBGene00000423", "P22981", "WBGene00002335" ] }, "reaction_10572669": { "compartment": "compartment_876", "id": "reaction_10572669", "reactome": "R-CEL-9647994", "name": "RAS proteins are depalmitoylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10511477" ], "products": [ "species_10511479", "species_8848337" ], "modifiers": [ [ "species_10572662", "catalyst" ], [ "species_10572664", "inhibitor" ] ], "additional_components": [ "WBGene00002335", "WBGene00002335", "Q9XVA7", "WBGene00044003", "Q21221", "WBGene00045192", "Q5FC17", "WBGene00044003", "Q7JKU8", "WBGene00044003", "Q9BL52", "WBGene00044003", "A0A061ACY0", "WBGene00010564", "Q9XVA7", "WBGene00044003", "Q21221", "WBGene00045192", "Q5FC17", "WBGene00044003", "Q7JKU8", "WBGene00044003", "Q9BL52", "WBGene00044003", "A0A061ACY0", "WBGene00010564" ] }, "reaction_10554992": { "compartment": "compartment_876", "id": "reaction_10554992", "reactome": "R-CEL-5672965", "name": "RAS GEFs promote RAS nucleotide exchange", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10512175", "species_29438" ], "products": [ "species_29420", "species_10511481" ], "modifiers": [ [ "species_10554989", "catalyst" ] ], "additional_components": [ "species_29420", "P22981", "WBGene00002335", "species_29438", "P22981", "WBGene00002335", "P29355", "WBGene00004774", "Q9N5D3", "WBGene00004947", "P24348", "WBGene00002299", "species_114519", "Q19770", "WBGene00009100", "W6RS10", "WBGene00019902", "Q9N413", "WBGene00004249", "G5EGT9", "WBGene00003007", "A0A1I6CMA1", "WBGene00020678", "Q9XWK4", "WBGene00013202", "Q9XVQ7", "WBGene00008711", "E0AHA7", "WBGene00006803", "G5EFW3", "WBGene00004855", "Q21408", "WBGene00004951", "Q7YZG5", "WBGene00021702", "C6KRM7", "WBGene00004372", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q95YD4", "WBGene00002213", "G5EDB9", "WBGene00004254" ] }, "reaction_10572929": { "compartment": "compartment_876", "id": "reaction_10572929", "reactome": "R-CEL-9658253", "name": "RAS:GTP binds PI3K", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10506892", "species_10511481" ], "products": [ "species_10572927" ], "modifiers": [], "additional_components": [ "G5EDP9", "WBGene00000001", "Q94125", "WBGene00000090", "species_29438", "P22981", "WBGene00002335", "species_29438", "P22981", "WBGene00002335", "G5EDP9", "WBGene00000001", "Q94125", "WBGene00000090" ] }, "reaction_10542176": { "compartment": "compartment_70101", "id": "reaction_10542176", "reactome": "R-CEL-2032768", "name": "Translocation of WWTR1 (TAZ) to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10541983" ], "products": [ "species_10542174" ], "modifiers": [], "additional_components": [ "WBGene00008748", "WBGene00008748" ] }, "reaction_10542432": { "compartment": "compartment_70101", "id": "reaction_10542432", "reactome": "R-CEL-2066299", "name": "DVL2 binds phosphorylated WWTR1 (TAZ)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10515048", "species_10541986" ], "products": [ "species_10542430" ], "modifiers": [], "additional_components": [ "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "WBGene00008748", "Q19404", "WBGene00008748", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241" ] }, "reaction_10542178": { "compartment": "compartment_70101", "id": "reaction_10542178", "reactome": "R-CEL-2032770", "name": "Translocation of YAP1 to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10532629" ], "products": [ "species_10532633" ], "modifiers": [], "additional_components": [ "WBGene00008748", "WBGene00008748" ] }, "reaction_10542339": { "compartment": "compartment_70101", "id": "reaction_10542339", "reactome": "R-CEL-2064406", "name": "Translocation of YAP1:ZO-2 (TJP2) to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10542333" ], "products": [ "species_10542337" ], "modifiers": [], "additional_components": [ "Q19404", "WBGene00008748", "Q8I103", "WBGene00013683", "Q19404", "WBGene00008748", "Q8I103", "WBGene00013683" ] }, "reaction_10541988": { "compartment": "compartment_70101", "id": "reaction_10541988", "reactome": "R-CEL-2028661", "name": "Phosphorylation of WWTR1 (TAZ) by LATS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10541983", "species_113592" ], "products": [ "species_29370", "species_10541986" ], "modifiers": [ [ "species_10541961", "catalyst" ] ], "additional_components": [ "WBGene00008748", "WBGene00008748", "O45797", "WBGene00007047", "Q20186", "WBGene00009551" ] }, "reaction_10542345": { "compartment": "compartment_70101", "id": "reaction_10542345", "reactome": "R-CEL-2064417", "name": "WWTR1 (TAZ) binds ZO-1 (TJP1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10541983", "species_10542341" ], "products": [ "species_10542343" ], "modifiers": [], "additional_components": [ "WBGene00008748", "WBGene00013683", "Q8I103", "WBGene00013683", "Q19404", "WBGene00008748" ] }, "reaction_10541964": { "compartment": "compartment_70101", "id": "reaction_10541964", "reactome": "R-CEL-2028583", "name": "Phosphorylation of YAP by LATS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10532629" ], "products": [ "species_29370", "species_10541959" ], "modifiers": [ [ "species_10541961", "catalyst" ] ], "additional_components": [ "WBGene00008748", "WBGene00008748", "O45797", "WBGene00007047", "Q20186", "WBGene00009551" ] }, "reaction_10542349": { "compartment": "compartment_70101", "id": "reaction_10542349", "reactome": "R-CEL-2064418", "name": "WWTR1 (TAZ) binds ZO-2 (TJP2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10541983", "species_10542331" ], "products": [ "species_10542347" ], "modifiers": [], "additional_components": [ "WBGene00008748", "WBGene00013683", "Q8I103", "WBGene00013683", "Q19404", "WBGene00008748" ] }, "reaction_10542351": { "compartment": "compartment_70101", "id": "reaction_10542351", "reactome": "R-CEL-2064421", "name": "YAP1 binds ZO-2 (TJP2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10542331", "species_10532629" ], "products": [ "species_10542333" ], "modifiers": [], "additional_components": [ "WBGene00013683", "WBGene00008748", "Q19404", "WBGene00008748", "Q8I103", "WBGene00013683" ] }, "reaction_10541973": { "compartment": "compartment_70101", "id": "reaction_10541973", "reactome": "R-CEL-2028598", "name": "Phosphorylation of YAP by LATS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10532629" ], "products": [ "species_29370", "species_10541970" ], "modifiers": [ [ "species_10541956", "catalyst" ] ], "additional_components": [ "WBGene00008748", "WBGene00008748", "Q20186", "WBGene00009551", "O45797", "WBGene00007047" ] }, "reaction_10542327": { "compartment": "compartment_70101", "id": "reaction_10542327", "reactome": "R-CEL-2059926", "name": "NPHP4 protein binds LATS proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10541935", "species_10542323" ], "products": [ "species_10542325" ], "modifiers": [], "additional_components": [ "WBGene00007047", "WBGene00011261", "G5ECP0", "WBGene00011261", "O45797", "WBGene00007047" ] }, "reaction_10541975": { "compartment": "compartment_70101", "id": "reaction_10541975", "reactome": "R-CEL-2028626", "name": "Phosphorylated MOB1A proteins associate with LATS proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10541935", "species_10541944" ], "products": [ "species_10541946" ], "modifiers": [], "additional_components": [ "WBGene00007047", "WBGene00009551", "Q20186", "WBGene00009551", "O45797", "WBGene00007047" ] }, "reaction_10542329": { "compartment": "compartment_70101", "id": "reaction_10542329", "reactome": "R-CEL-2060328", "name": "Phosphorylation of WWTR1 (TAZ) by LATS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10541983", "species_113592" ], "products": [ "species_29370", "species_10541986" ], "modifiers": [ [ "species_10541956", "catalyst" ] ], "additional_components": [ "WBGene00008748", "WBGene00008748", "Q20186", "WBGene00009551", "O45797", "WBGene00007047" ] }, "reaction_10541981": { "compartment": "compartment_70101", "id": "reaction_10541981", "reactome": "R-CEL-2028644", "name": "YWHAB (14-3-3 beta/alpha) dimer binds phosphorylated YAP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10507067", "species_10541959" ], "products": [ "species_10541979" ], "modifiers": [], "additional_components": [ "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "WBGene00008748", "Q19404", "WBGene00008748", "P41932", "WBGene00003920", "Q20655", "WBGene00001502" ] }, "reaction_10573312": { "compartment": "compartment_263163", "id": "reaction_10573312", "reactome": "R-CEL-9706390", "name": "RHOBTB3 binds interacting proteins at trans-Golgi network", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10573308", "species_10573304" ], "products": [ "species_10573310" ], "modifiers": [], "additional_components": [ "O01501", "WBGene00000871", "Q19213", "WBGene00006922", "Q17796", "WBGene00004101", "Q22895", "WBGene00004780", "Q17391", "WBGene00000838", "Q03206", "ced-10", "Q94124", "WBGene00004287", "Q9BL44", "WBGene00022177", "species_29358", "Q03206", "ced-10", "Q94124", "WBGene00004287", "Q9BL44", "WBGene00022177", "species_29358", "O01501", "WBGene00000871", "Q19213", "WBGene00006922", "Q17796", "WBGene00004101", "Q22895", "WBGene00004780", "Q17391", "WBGene00000838" ] }, "reaction_10573314": { "compartment": "compartment_263163", "id": "reaction_10573314", "reactome": "R-CEL-9706393", "name": "RHOBTB3 binds ATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10573302" ], "products": [ "species_10573304" ], "modifiers": [], "additional_components": [ "Q03206", "ced-10", "Q94124", "WBGene00004287", "Q9BL44", "WBGene00022177", "Q03206", "ced-10", "Q94124", "WBGene00004287", "Q9BL44", "WBGene00022177", "species_29358" ] }, "reaction_10573319": { "compartment": "compartment_263163", "id": "reaction_10573319", "reactome": "R-CEL-9706399", "name": "RHOBTB3 hydrolyzes ATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10573304" ], "products": [ "species_29372", "species_10573316" ], "modifiers": [ [ "species_10573304", "catalyst" ] ], "additional_components": [ "Q03206", "ced-10", "Q94124", "WBGene00004287", "Q9BL44", "WBGene00022177", "species_29358", "Q03206", "ced-10", "Q94124", "WBGene00004287", "Q9BL44", "WBGene00022177", "species_113582", "Q03206", "ced-10", "Q94124", "WBGene00004287", "Q9BL44", "WBGene00022177", "species_29358" ] }, "reaction_10571460": { "compartment": "compartment_17906", "id": "reaction_10571460", "reactome": "R-CEL-9018815", "name": "RHOT1 binds effectors at the mitochondrial outer membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10571454", "species_10571444" ], "products": [ "species_10571458" ], "modifiers": [], "additional_components": [ "WBGene00020838", "Q94263", "WBGene00019544", "species_29438", "Q94263", "WBGene00019544", "species_29438", "P91503", "WBGene00020838" ] }, "reaction_10571449": { "compartment": "compartment_70101", "id": "reaction_10571449", "reactome": "R-CEL-9018814", "name": "RHOT1 hydrolyzes GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10571444" ], "products": [ "species_29372", "species_10571446" ], "modifiers": [ [ "species_10571444", "catalyst" ] ], "additional_components": [ "Q94263", "WBGene00019544", "species_29438", "Q94263", "WBGene00019544", "species_29420", "Q94263", "WBGene00019544", "species_29438" ] }, "reaction_10571466": { "compartment": "compartment_70101", "id": "reaction_10571466", "reactome": "R-CEL-9018824", "name": "RHOT2 binds effectors at the mitochondrial outer membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10571462", "species_10571444" ], "products": [ "species_10571464" ], "modifiers": [], "additional_components": [ "Q23424", "WBGene00001509", "P91503", "WBGene00020838", "Q94263", "WBGene00019544", "species_29438", "Q94263", "WBGene00019544", "species_29438", "Q23424", "WBGene00001509", "P91503", "WBGene00020838" ] }, "reaction_10571468": { "compartment": "compartment_70101", "id": "reaction_10571468", "reactome": "R-CEL-9018826", "name": "RHOT2 hydrolyzes GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10571444" ], "products": [ "species_29372", "species_10571446" ], "modifiers": [ [ "species_10571444", "catalyst" ] ], "additional_components": [ "Q94263", "WBGene00019544", "species_29438", "Q94263", "WBGene00019544", "species_29420", "Q94263", "WBGene00019544", "species_29438" ] }, "reaction_10564802": { "compartment": "compartment_70101", "id": "reaction_10564802", "reactome": "R-CEL-8849055", "name": "PTK6 binds ARHGAP35", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10564606", "species_10521590" ], "products": [ "species_10564800" ], "modifiers": [], "additional_components": [ "A0A0K3ARA3", "WBGene00020106", "Q10925", "WBGene00002207", "WBGene00010374", "O45611", "WBGene00010374", "A0A0K3ARA3", "WBGene00020106", "Q10925", "WBGene00002207" ] }, "reaction_10564808": { "compartment": "compartment_70101", "id": "reaction_10564808", "reactome": "R-CEL-8849068", "name": "PTK6 phosphorylates ARHGAP35", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10564800" ], "products": [ "species_10564606", "species_29370", "species_10564805" ], "modifiers": [ [ "species_10564800", "catalyst" ] ], "additional_components": [ "O45611", "WBGene00010374", "A0A0K3ARA3", "WBGene00020106", "Q10925", "WBGene00002207", "A0A0K3ARA3", "WBGene00020106", "Q10925", "WBGene00002207", "WBGene00010374", "O45611", "WBGene00010374", "A0A0K3ARA3", "WBGene00020106", "Q10925", "WBGene00002207" ] }, "reaction_10564731": { "compartment": "compartment_876", "id": "reaction_10564731", "reactome": "R-CEL-8848618", "name": "Activation of RAC1 by the PXN:CRK complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10541992" ], "products": [ "species_29420", "species_10509457" ], "modifiers": [ [ "species_10564728", "catalyst" ] ], "additional_components": [ "species_29420", "Q03206", "ced-10", "species_29438", "Q03206", "ced-10", "Q8STE5", "WBGene00000426", "Q95XA9", "WBGene00021238", "Q9NHC3", "WBGene00000416", "G5EEN3", "WBGene00000419" ] }, "reaction_10564813": { "compartment": "compartment_70101", "id": "reaction_10564813", "reactome": "R-CEL-8849082", "name": "ARHGAP35 stimulates RHOA GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10564810" ], "products": [ "species_10509486", "species_29372", "species_10564805" ], "modifiers": [ [ "species_10564810", "catalyst" ] ], "additional_components": [ "Q22038", "WBGene00004357", "species_29438", "O45611", "WBGene00010374", "Q22038", "WBGene00004357", "species_29420", "WBGene00010374", "Q22038", "WBGene00004357", "species_29438", "O45611", "WBGene00010374" ] }, "reaction_10564815": { "compartment": "compartment_70101", "id": "reaction_10564815", "reactome": "R-CEL-8849085", "name": "ARHGAP35 binds RHOA:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10564805", "species_10509488" ], "products": [ "species_10564810" ], "modifiers": [], "additional_components": [ "WBGene00010374", "Q22038", "WBGene00004357", "species_29438", "Q22038", "WBGene00004357", "species_29438", "O45611", "WBGene00010374" ] }, "reaction_10564769": { "compartment": "compartment_70101", "id": "reaction_10564769", "reactome": "R-CEL-8848818", "name": "PTK6 phosphorylates CBL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10512267", "species_113592" ], "products": [ "species_10528460", "species_29370" ], "modifiers": [ [ "species_10564606", "catalyst" ] ], "additional_components": [ "WBGene00004829", "WBGene00004829", "A0A0K3ARA3", "WBGene00020106", "Q10925", "WBGene00002207" ] }, "reaction_10564784": { "compartment": "compartment_70101", "id": "reaction_10564784", "reactome": "R-CEL-8848864", "name": "PTK6 binds ARAP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10564606", "species_10564780" ], "products": [ "species_10564782" ], "modifiers": [], "additional_components": [ "A0A0K3ARA3", "WBGene00020106", "Q10925", "WBGene00002207", "WBGene00017760", "H2KZV4", "WBGene00017760", "A0A0K3ARA3", "WBGene00020106", "Q10925", "WBGene00002207" ] }, "reaction_10564754": { "compartment": "compartment_70101", "id": "reaction_10564754", "reactome": "R-CEL-8848758", "name": "PTK6 phosphorylates AKT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10564733", "species_113592" ], "products": [ "species_10564751", "species_29370" ], "modifiers": [ [ "species_10564733", "catalyst" ] ], "additional_components": [ "G4S4W1", "WBGene00016980", "Q17941", "WBGene00000102", "Q9XTG7", "WBGene00000103", "A0A0K3ARA3", "WBGene00020106", "Q10925", "WBGene00002207", "G4S4W1", "WBGene00016980", "Q17941", "WBGene00000102", "Q9XTG7", "WBGene00000103", "A0A0K3ARA3", "WBGene00020106", "Q10925", "WBGene00002207", "G4S4W1", "WBGene00016980", "Q17941", "WBGene00000102", "Q9XTG7", "WBGene00000103", "A0A0K3ARA3", "WBGene00020106", "Q10925", "WBGene00002207" ] }, "reaction_10564775": { "compartment": "compartment_70101", "id": "reaction_10564775", "reactome": "R-CEL-8848829", "name": "CBL autoubiquitinates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10528460", "species_10502375" ], "products": [ "species_10564772" ], "modifiers": [ [ "species_10528460", "catalyst" ] ], "additional_components": [ "WBGene00004829", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "WBGene00004829", "WBGene00004829" ] }, "reaction_10564790": { "compartment": "compartment_70101", "id": "reaction_10564790", "reactome": "R-CEL-8848873", "name": "PTK6 phosphorylates ARAP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10564782", "species_113592" ], "products": [ "species_10564606", "species_29370", "species_10564787" ], "modifiers": [ [ "species_10564782", "catalyst" ] ], "additional_components": [ "H2KZV4", "WBGene00017760", "A0A0K3ARA3", "WBGene00020106", "Q10925", "WBGene00002207", "A0A0K3ARA3", "WBGene00020106", "Q10925", "WBGene00002207", "WBGene00017760", "H2KZV4", "WBGene00017760", "A0A0K3ARA3", "WBGene00020106", "Q10925", "WBGene00002207" ] }, "reaction_10564760": { "compartment": "compartment_70101", "id": "reaction_10564760", "reactome": "R-CEL-8848774", "name": "PTK6 binds DOK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10564606", "species_10564756" ], "products": [ "species_10564758" ], "modifiers": [], "additional_components": [ "A0A0K3ARA3", "WBGene00020106", "Q10925", "WBGene00002207", "WBGene00018819", "E6N0V1", "WBGene00018819", "A0A0K3ARA3", "WBGene00020106", "Q10925", "WBGene00002207" ] }, "reaction_10564735": { "compartment": "compartment_70101", "id": "reaction_10564735", "reactome": "R-CEL-8848751", "name": "PTK6 binds AKT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10564606", "species_10520798" ], "products": [ "species_10564733" ], "modifiers": [], "additional_components": [ "A0A0K3ARA3", "WBGene00020106", "Q10925", "WBGene00002207", "G4S4W1", "WBGene00016980", "Q17941", "WBGene00000102", "Q9XTG7", "WBGene00000103", "G4S4W1", "WBGene00016980", "Q17941", "WBGene00000102", "Q9XTG7", "WBGene00000103", "A0A0K3ARA3", "WBGene00020106", "Q10925", "WBGene00002207" ] }, "reaction_10564766": { "compartment": "compartment_70101", "id": "reaction_10564766", "reactome": "R-CEL-8848776", "name": "PTK6 phosphorylates DOK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10564758" ], "products": [ "species_10564606", "species_10564763", "species_29370" ], "modifiers": [ [ "species_10564758", "catalyst" ] ], "additional_components": [ "E6N0V1", "WBGene00018819", "A0A0K3ARA3", "WBGene00020106", "Q10925", "WBGene00002207", "A0A0K3ARA3", "WBGene00020106", "Q10925", "WBGene00002207", "WBGene00018819", "E6N0V1", "WBGene00018819", "A0A0K3ARA3", "WBGene00020106", "Q10925", "WBGene00002207" ] }, "reaction_10564930": { "compartment": "compartment_7660", "id": "reaction_10564930", "reactome": "R-CEL-8849463", "name": "PTK6 phosphorylates SFPQ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10564924" ], "products": [ "species_113582", "species_10564927" ], "modifiers": [ [ "species_10564796", "catalyst" ] ], "additional_components": [ "WBGene00017778", "WBGene00017778", "A0A0K3ARA3", "WBGene00020106", "Q10925", "WBGene00002207" ] }, "reaction_10564798": { "compartment": "compartment_70101", "id": "reaction_10564798", "reactome": "R-CEL-8848930", "name": "PTK6 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10564606" ], "products": [ "species_10564796" ], "modifiers": [], "additional_components": [ "A0A0K3ARA3", "WBGene00020106", "Q10925", "WBGene00002207", "A0A0K3ARA3", "WBGene00020106", "Q10925", "WBGene00002207" ] }, "reaction_10564828": { "compartment": "compartment_70101", "id": "reaction_10564828", "reactome": "R-CEL-8849102", "name": "SRMS phosphorylates PTK6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10564606", "species_113592" ], "products": [ "species_29370", "species_10564823" ], "modifiers": [ [ "species_10564825", "catalyst" ] ], "additional_components": [ "A0A0K3ARA3", "WBGene00020106", "Q10925", "WBGene00002207", "A0A0K3ARA3", "WBGene00020106", "Q10925", "WBGene00002207", "WBGene00020106" ] }, "reaction_10564610": { "compartment": "compartment_70101", "id": "reaction_10564610", "reactome": "R-CEL-8848110", "name": "SOCS3 binds activated PTK6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10564606", "species_10531061" ], "products": [ "species_10564608" ], "modifiers": [], "additional_components": [ "A0A0K3ARA3", "WBGene00020106", "Q10925", "WBGene00002207", "WBGene00009556", "O45498", "WBGene00009556", "A0A0K3ARA3", "WBGene00020106", "Q10925", "WBGene00002207" ] }, "reaction_10515265": { "compartment": "compartment_947587", "id": "reaction_10515265", "reactome": "R-CEL-202626", "name": "I-Smad competes with Co-Smad for R-Smad1/5/8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10515259", "species_10514789" ], "products": [ "species_10515263" ], "modifiers": [], "additional_components": [ "WBGene00006445", "Q02330", "WBGene00004856", "F5GUE5", "WBGene00000910", "P45896", "WBGene00004857", "Q02330", "WBGene00004856", "F5GUE5", "WBGene00000910", "P45896", "WBGene00004857", "G5EDS9", "WBGene00006445" ] }, "reaction_10514817": { "compartment": "compartment_7660", "id": "reaction_10514817", "reactome": "R-CEL-201425", "name": "Ubiquitin-dependent degradation of the Smad complex terminates BMP2 signalling", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10514815" ], "products": [], "modifiers": [ [ "species_10511544", "catalyst" ] ], "additional_components": [ "P45897", "WBGene00004858", "F5GUE5", "WBGene00000910", "P45896", "WBGene00004857", "Q02330", "WBGene00004856", "P35129", "WBGene00002344", "P91853", "WBGene00006732", "Q17720", "WBGene00006717", "Q20617", "WBGene00006719" ] }, "reaction_10514839": { "compartment": "compartment_13231", "id": "reaction_10514839", "reactome": "R-CEL-201472", "name": "The phospho-R-Smad1/5/8:Co-Smad transfers to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10514791" ], "products": [ "species_10514815" ], "modifiers": [], "additional_components": [ "Q02330", "WBGene00004856", "F5GUE5", "WBGene00000910", "P45896", "WBGene00004857", "P45897", "WBGene00004858", "P45897", "WBGene00004858", "F5GUE5", "WBGene00000910", "P45896", "WBGene00004857", "Q02330", "WBGene00004856" ] }, "reaction_10514793": { "compartment": "compartment_70101", "id": "reaction_10514793", "reactome": "R-CEL-201422", "name": "Phospho-R-Smad1/5/8 forms a complex with Co-Smad", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10511404", "species_10514789" ], "products": [ "species_10514791" ], "modifiers": [], "additional_components": [ "WBGene00004858", "Q02330", "WBGene00004856", "F5GUE5", "WBGene00000910", "P45896", "WBGene00004857", "Q02330", "WBGene00004856", "F5GUE5", "WBGene00000910", "P45896", "WBGene00004857", "P45897", "WBGene00004858" ] }, "reaction_10571958": { "compartment": "compartment_13231", "id": "reaction_10571958", "reactome": "R-CEL-9604308", "name": "NICD4 traffics to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10571948" ], "products": [ "species_10517150" ], "modifiers": [ [ "species_10571956", "inhibitor" ] ], "additional_components": [ "WBGene00019957", "WBGene00019957", "Q21850", "WBGene00019957", "Q20655", "WBGene00001502", "P41932", "WBGene00003920" ] }, "reaction_10571961": { "compartment": "compartment_70101", "id": "reaction_10571961", "reactome": "R-CEL-9604328", "name": "AKT1 phosphorylates NOTCH4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10571948", "species_113592" ], "products": [ "species_29370", "species_10571954" ], "modifiers": [ [ "species_10513843", "catalyst" ] ], "additional_components": [ "WBGene00019957", "WBGene00019957", "Q9XTG7", "WBGene00000103", "G4S4W1", "WBGene00016980", "Q17941", "WBGene00000102" ] }, "reaction_10546960": { "compartment": "compartment_20699", "id": "reaction_10546960", "reactome": "R-CEL-3247844", "name": "WNT ligands traffic to the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546918" ], "products": [ "species_10546940" ], "modifiers": [], "additional_components": [ "P34888", "WBGene00000857", "P34889", "WBGene00000858", "Q7YWX7", "WBGene00003246", "Q7YWX7", "WBGene00003246", "P34888", "WBGene00000857", "P34889", "WBGene00000858" ] }, "reaction_10548112": { "compartment": "compartment_876", "id": "reaction_10548112", "reactome": "R-CEL-3781943", "name": "WLS:WNT complex is internalized for maturation into exosomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546940" ], "products": [ "species_10548088" ], "modifiers": [], "additional_components": [ "Q7YWX7", "WBGene00003246", "P34888", "WBGene00000857", "P34889", "WBGene00000858", "Q7YWX7", "WBGene00003246", "P34888", "WBGene00000857", "P34889", "WBGene00000858" ] }, "reaction_10546848": { "compartment": "compartment_20699", "id": "reaction_10546848", "reactome": "R-CEL-3247836", "name": "Retromer recycles WLS to the Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546842" ], "products": [ "species_10546846" ], "modifiers": [], "additional_components": [ "Q7YWX7", "WBGene00003246", "Q9XW41", "WBGene00006503", "O01258", "WBGene00006931", "Q86D99", "WBGene00014234", "Q21053", "WBGene00006933", "Q9XW41", "WBGene00006503", "Q7YWX7", "WBGene00003246", "O01258", "WBGene00006931", "Q86D99", "WBGene00014234", "Q21053", "WBGene00006933" ] }, "reaction_10546913": { "compartment": "compartment_17963", "id": "reaction_10546913", "reactome": "R-CEL-3247837", "name": "WNT ligands traffic to the Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546890" ], "products": [ "species_10546906" ], "modifiers": [ [ "species_10546911", "catalyst" ] ], "additional_components": [ "P34888", "WBGene00000857", "P34889", "WBGene00000858", "P34888", "WBGene00000857", "P34889", "WBGene00000858", "WBGene00010670" ] }, "reaction_10546962": { "compartment": "compartment_171062", "id": "reaction_10546962", "reactome": "R-CEL-3247847", "name": "WLS is endocytosed to the early endosome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546922" ], "products": [ "species_10546835" ], "modifiers": [], "additional_components": [ "WBGene00003246", "WBGene00003246" ] }, "reaction_10546916": { "compartment": "compartment_171062", "id": "reaction_10546916", "reactome": "R-CEL-3247839", "name": "Retromer associates with WLS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546830", "species_10546840", "species_10546835" ], "products": [ "species_10546842" ], "modifiers": [], "additional_components": [ "O01258", "WBGene00006931", "Q86D99", "WBGene00014234", "Q21053", "WBGene00006933", "WBGene00006503", "WBGene00003246", "Q7YWX7", "WBGene00003246", "Q9XW41", "WBGene00006503", "O01258", "WBGene00006931", "Q86D99", "WBGene00014234", "Q21053", "WBGene00006933" ] }, "reaction_10546964": { "compartment": "compartment_20699", "id": "reaction_10546964", "reactome": "R-CEL-3247849", "name": "WLS dissociates from retromer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546846" ], "products": [ "species_10546830", "species_10546844", "species_10546840" ], "modifiers": [], "additional_components": [ "Q9XW41", "WBGene00006503", "Q7YWX7", "WBGene00003246", "O01258", "WBGene00006931", "Q86D99", "WBGene00014234", "Q21053", "WBGene00006933", "O01258", "WBGene00006931", "Q86D99", "WBGene00014234", "Q21053", "WBGene00006933", "WBGene00003246", "WBGene00006503" ] }, "reaction_10546920": { "compartment": "compartment_20699", "id": "reaction_10546920", "reactome": "R-CEL-3247840", "name": "WLS binds WNT ligands in the Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546844", "species_10546906" ], "products": [ "species_10546918" ], "modifiers": [], "additional_components": [ "WBGene00003246", "P34888", "WBGene00000857", "P34889", "WBGene00000858", "P34888", "WBGene00000857", "P34889", "WBGene00000858", "Q7YWX7", "WBGene00003246" ] }, "reaction_10548110": { "compartment": "compartment_383505", "id": "reaction_10548110", "reactome": "R-CEL-3781941", "name": "WNTs are secreted in exosomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10548088" ], "products": [ "species_10548108" ], "modifiers": [], "additional_components": [ "Q7YWX7", "WBGene00003246", "P34888", "WBGene00000857", "P34889", "WBGene00000858", "Q7YWX7", "WBGene00003246", "P34888", "WBGene00000857", "P34889", "WBGene00000858" ] }, "reaction_10546958": { "compartment": "compartment_984", "id": "reaction_10546958", "reactome": "R-CEL-3247843", "name": "secretion of WNT ligands", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546940" ], "products": [ "species_10546956", "species_10546922" ], "modifiers": [], "additional_components": [ "Q7YWX7", "WBGene00003246", "P34888", "WBGene00000857", "P34889", "WBGene00000858", "Q27886", "WBGene00003029", "Q10459", "WBGene00003395", "G5EG05", "WBGene00001188", "P34888", "WBGene00000857", "P34889", "WBGene00000858", "WBGene00003246" ] }, "reaction_10549441": { "compartment": "compartment_70101", "id": "reaction_10549441", "reactome": "R-CEL-4641159", "name": "DVL1 is ubiquitinated by HECW1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10549434", "species_10502375" ], "products": [ "species_10549438" ], "modifiers": [ [ "species_10549434", "catalyst" ] ], "additional_components": [ "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "Q09291", "WBGene00009738", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "A0A0K3AUI8", "C34F11.9e", "Q09291", "WBGene00009738", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "Q09291", "WBGene00009738" ] }, "reaction_10549445": { "compartment": "compartment_70101", "id": "reaction_10549445", "reactome": "R-CEL-4641260", "name": "Ubiquitinated DVL1 is degraded by the proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10549438" ], "products": [ "species_10549432", "species_10502375" ], "modifiers": [ [ "species_10502572", "catalyst" ] ], "additional_components": [ "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "A0A0K3AUI8", "C34F11.9e", "Q09291", "WBGene00009738", "WBGene00009738", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "P91477", "WBGene00003950", "Q95PZ7", "WBGene00013435", "Q18115", "WBGene00004459", "O62102", "WBGene00003948", "O17071", "WBGene00004504", "Q10920", "WBGene00016623", "P34286", "WBGene00003952", "Q9XTT9", "WBGene00004506", "Q23449", "WBGene00004468", "Q95005", "WBGene00003925", "P46502", "WBGene00004503", "O61792", "WBGene00004464", "O17586", "WBGene00003922", "O76371", "WBGene00004505", "Q20585", "WBGene00004463", "Q95008", "WBGene00003926", "Q18787", "WBGene00004501", "Q20058", "WBGene00009445", "Q9N599", "WBGene00003924", "O16368", "WBGene00004502", "O61742", "WBGene00004466", "Q09583", "WBGene00003928", "Q966I8", "WBGene00003947", "Q04908", "WBGene00004460", "Q9XUV0", "WBGene00003951", "Q27488", "WBGene00003923", "Q9GZH5", "WBGene00004458", "O44156", "WBGene00003927", "Q22253", "WBGene00004465", "O76577", "WBGene00004467", "P90868", "WBGene00003953", "Q19324", "WBGene00004461", "Q17971", "WBGene00007588", "Q23237", "WBGene00003949", "Q20938", "WBGene00004462" ] }, "reaction_10535195": { "compartment": "compartment_70101", "id": "reaction_10535195", "reactome": "R-CEL-1504190", "name": "DVL is ubiquitinated by CUL3:KLHL12:RBX1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10535167", "species_10502375" ], "products": [ "species_10535192" ], "modifiers": [ [ "species_10535167", "catalyst" ] ], "additional_components": [ "Q23457", "WBGene00004320", "Q17391", "WBGene00000838", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "Q23457", "WBGene00004320", "Q17391", "WBGene00000838", "Q23457", "WBGene00004320", "Q17391", "WBGene00000838", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241" ] }, "reaction_10549436": { "compartment": "compartment_70101", "id": "reaction_10549436", "reactome": "R-CEL-4641155", "name": "DVL1 is bound by the HECT ubiquitin ligase HECW1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10549432", "species_10515040" ], "products": [ "species_10549434" ], "modifiers": [], "additional_components": [ "WBGene00009738", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "Q09291", "WBGene00009738" ] }, "reaction_10547556": { "compartment": "compartment_7660", "id": "reaction_10547556", "reactome": "R-CEL-3364026", "name": "SET1 complex trimethylates H3K4 at the MYC gene", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10547529" ], "products": [ "species_77502", "species_10547533" ], "modifiers": [ [ "species_10547553", "catalyst" ] ], "additional_components": [ "P62784", "WBGene00001875", "P62784", "WBGene00001875", "G5EFZ3", "WBGene00012458", "Q10666", "WBGene00004077", "Q09309", "WBGene00017683", "O44326", "WBGene00001979", "G5EGI1", "WBGene00011729", "O44447", "WBGene00015330" ] }, "reaction_10547174": { "compartment": "compartment_7660", "id": "reaction_10547174", "reactome": "R-CEL-3299569", "name": "Beta-catenin displaces TLE:HDAC1 from TCF/LEF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10514938", "species_10547170" ], "products": [ "species_10547166", "species_10532119", "species_10547172" ], "modifiers": [], "additional_components": [ "WBGene00001979", "G5ECH0", "WBGene00001836", "O02482", "WBGene00006773", "Q10666", "WBGene00004077", "O02482", "WBGene00006773", "WBGene00001836", "Q10666", "WBGene00004077", "O44326", "WBGene00001979" ] }, "reaction_10547387": { "compartment": "compartment_7660", "id": "reaction_10547387", "reactome": "R-CEL-3322424", "name": "Beta-catenin recruits CDC73 and LEO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509311", "species_10509321", "species_10547172" ], "products": [ "species_10547385" ], "modifiers": [], "additional_components": [ "WBGene00018064", "WBGene00007110", "Q10666", "WBGene00004077", "O44326", "WBGene00001979", "Q10666", "WBGene00004077", "O44326", "WBGene00001979", "Q17431", "WBGene00007110", "Q9N5U5", "WBGene00018064" ] }, "reaction_10547391": { "compartment": "compartment_7660", "id": "reaction_10547391", "reactome": "R-CEL-3322427", "name": "Beta-catenin recruits CBP/p300", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10547172", "species_10532226" ], "products": [ "species_10547389" ], "modifiers": [], "additional_components": [ "Q10666", "WBGene00004077", "O44326", "WBGene00001979", "WBGene00000366", "P34545", "WBGene00000366", "Q10666", "WBGene00004077", "O44326", "WBGene00001979" ] }, "reaction_10514940": { "compartment": "compartment_70101", "id": "reaction_10514940", "reactome": "R-CEL-201669", "name": "Beta-catenin translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10513633" ], "products": [ "species_10514938" ], "modifiers": [], "additional_components": [ "WBGene00001979", "WBGene00001979" ] }, "reaction_10553858": { "compartment": "compartment_7660", "id": "reaction_10553858", "reactome": "R-CEL-5626938", "name": "Beta-catenin binds SOX proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10553854", "species_10514938" ], "products": [ "species_10553856" ], "modifiers": [], "additional_components": [ "Q8T3B9", "WBGene00004771", "A0A1N7SZG1", "WBGene00015716", "Q20201", "WBGene00004950", "Q21305", "WBGene00004949", "Q23045", "WBGene00001182", "WBGene00001979", "O44326", "WBGene00001979", "Q8T3B9", "WBGene00004771", "A0A1N7SZG1", "WBGene00015716", "Q20201", "WBGene00004950", "Q21305", "WBGene00004949", "Q23045", "WBGene00001182" ] }, "reaction_10554594": { "compartment": "compartment_7660", "id": "reaction_10554594", "reactome": "R-CEL-5665608", "name": "TCF:Beta-catenin binds SOX proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10554590", "species_10547172" ], "products": [ "species_10554592" ], "modifiers": [], "additional_components": [ "Q8T3B9", "WBGene00004771", "A0A1N7SZG1", "WBGene00015716", "Q20201", "WBGene00004950", "Q21305", "WBGene00004949", "Q23045", "WBGene00001182", "Q10666", "WBGene00004077", "O44326", "WBGene00001979", "Q10666", "WBGene00004077", "O44326", "WBGene00001979", "Q8T3B9", "WBGene00004771", "A0A1N7SZG1", "WBGene00015716", "Q20201", "WBGene00004950", "Q21305", "WBGene00004949", "Q23045", "WBGene00001182" ] }, "reaction_10547479": { "compartment": "compartment_7660", "id": "reaction_10547479", "reactome": "R-CEL-3361751", "name": "beta-catenin is replaced by repression complexes at the promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10547475", "species_10547473" ], "products": [ "species_10547477", "species_10547170" ], "modifiers": [], "additional_components": [ "O02482", "WBGene00006773", "G5ECH0", "WBGene00001836", "Q10666", "WBGene00004077", "O44326", "WBGene00001979", "Q21227", "WBGene00000156", "Q20595", "WBGene00006424", "O44326", "WBGene00001979", "Q21227", "WBGene00000156", "Q20595", "WBGene00006424", "G5ECH0", "WBGene00001836", "O02482", "WBGene00006773", "Q10666", "WBGene00004077" ] }, "reaction_10547948": { "compartment": "compartment_70101", "id": "reaction_10547948", "reactome": "R-CEL-3769392", "name": "YWHAZ and XPO1 mediate the nuclear export of beta-catenin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10547940" ], "products": [ "species_10547946" ], "modifiers": [], "additional_components": [ "Q23089", "WBGene00002078", "O44326", "WBGene00001979", "Q20655", "WBGene00001502", "P41932", "WBGene00003920", "O44326", "WBGene00001979", "Q20655", "WBGene00001502", "P41932", "WBGene00003920", "Q23089", "WBGene00002078" ] }, "reaction_10551790": { "compartment": "compartment_7660", "id": "reaction_10551790", "reactome": "R-CEL-5368580", "name": "CHD8 binds beta-catenin to negatively regulate WNT-dependent gene expression", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10551786", "species_10514938" ], "products": [ "species_10551788" ], "modifiers": [], "additional_components": [ "WBGene00007053", "WBGene00001979", "O44326", "WBGene00001979", "O61845", "WBGene00007053" ] }, "reaction_10524625": { "compartment": "compartment_876", "id": "reaction_10524625", "reactome": "R-CEL-444393", "name": "RhCG mediates ammonium influx into kidney collecting duct cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_140912" ], "products": [ "species_351626", "species_31633" ], "modifiers": [ [ "species_10524622", "catalyst" ] ], "additional_components": [ "Q17463", "WBGene00004359", "Q22947", "WBGene00004358" ] }, "reaction_10525188": { "compartment": "compartment_876", "id": "reaction_10525188", "reactome": "R-CEL-446277", "name": "RhCG mediates ammonium efflux out of kidney collecting duct cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_31633" ], "products": [ "species_70106", "species_140912" ], "modifiers": [ [ "species_10524622", "catalyst" ] ], "additional_components": [ "Q17463", "WBGene00004359", "Q22947", "WBGene00004358" ] }, "reaction_10525190": { "compartment": "compartment_876", "id": "reaction_10525190", "reactome": "R-CEL-446278", "name": "RhBG mediates ammonium influx into kidney collecting duct cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_140912" ], "products": [ "species_351626", "species_31633" ], "modifiers": [ [ "species_10524636", "catalyst" ] ], "additional_components": [ "WBGene00004358" ] }, "reaction_10524634": { "compartment": "compartment_876", "id": "reaction_10524634", "reactome": "R-CEL-444416", "name": "RHAG transports NH4+ from cytosol to extracellular region (red blood cells)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_31633" ], "products": [ "species_140912" ], "modifiers": [ [ "species_10524631", "catalyst" ] ], "additional_components": [ "Q17463", "WBGene00004359", "Q22947", "WBGene00004358" ] }, "reaction_10524639": { "compartment": "compartment_876", "id": "reaction_10524639", "reactome": "R-CEL-444419", "name": "RhBG mediates ammonium effflux out of kidney collecting duct cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_31633" ], "products": [ "species_70106", "species_140912" ], "modifiers": [ [ "species_10524636", "catalyst" ] ], "additional_components": [ "WBGene00004358" ] }, "reaction_10524112": { "compartment": "compartment_876", "id": "reaction_10524112", "reactome": "R-CEL-433101", "name": "NaDC3 co-transports the dicarboxylic acid succinate and three sodium ion", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_433123", "species_74113" ], "products": [ "species_29434", "species_83910" ], "modifiers": [ [ "species_10524109", "catalyst" ] ], "additional_components": [ "P32739", "WBGene00003518", "P46556", "WBGene00007138", "Q21339", "WBGene00003519", "Q93655", "WBGene00003517" ] }, "reaction_10524130": { "compartment": "compartment_876", "id": "reaction_10524130", "reactome": "R-CEL-433114", "name": "NaS1 co-transports sulphate and a sodium ion", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_427648", "species_74113" ], "products": [ "species_83910", "species_174375" ], "modifiers": [ [ "species_10524127", "catalyst" ] ], "additional_components": [ "P32739", "WBGene00003518", "P46556", "WBGene00007138", "Q21339", "WBGene00003519", "Q93655", "WBGene00003517" ] }, "reaction_10524099": { "compartment": "compartment_876", "id": "reaction_10524099", "reactome": "R-CEL-433099", "name": "NaS2 co-transports sulphate and two sodium ions", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_427648", "species_74113" ], "products": [ "species_83910", "species_174375" ], "modifiers": [ [ "species_10524096", "catalyst" ] ], "additional_components": [ "P46556", "WBGene00007138", "Q21339", "WBGene00003519", "Q93655", "WBGene00003517", "P32739", "WBGene00003518" ] }, "reaction_10524117": { "compartment": "compartment_876", "id": "reaction_10524117", "reactome": "R-CEL-433104", "name": "NACT co-transports trivalent citrate and a sodium ion", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_433138", "species_74113" ], "products": [ "species_76190", "species_83910" ], "modifiers": [ [ "species_10524114", "catalyst" ] ], "additional_components": [ "WBGene00003517" ] }, "reaction_10524143": { "compartment": "compartment_876", "id": "reaction_10524143", "reactome": "R-CEL-433131", "name": "NaDC1 co-transports dicarboxylic acids and a sodium ion", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_433111", "species_74113" ], "products": [ "species_83910", "species_433124" ], "modifiers": [ [ "species_10524140", "catalyst" ] ], "additional_components": [ "species_76190", "species_1650769", "species_1650769", "species_76190", "P32739", "WBGene00003518", "P46556", "WBGene00007138", "Q21339", "WBGene00003519", "Q93655", "WBGene00003517" ] }, "reaction_10523391": { "compartment": "compartment_876", "id": "reaction_10523391", "reactome": "R-CEL-429101", "name": "HMIT co-transports myo-inositol with a proton", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_429130" ], "products": [ "species_70106", "species_426910" ], "modifiers": [ [ "species_10523388", "catalyst" ] ], "additional_components": [ "WBGene00010811" ] }, "reaction_10524074": { "compartment": "compartment_876", "id": "reaction_10524074", "reactome": "R-CEL-433089", "name": "SOAT can transport taurolithocholate-3-sulphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_433120", "species_74113" ], "products": [ "species_83910", "species_176483" ], "modifiers": [ [ "species_10524071", "catalyst" ] ], "additional_components": [ "WBGene00044650" ] }, "reaction_10524593": { "compartment": "compartment_876", "id": "reaction_10524593", "reactome": "R-CEL-444160", "name": "VMAT1/2 can mediate the transport of biogenic amines", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_444154" ], "products": [ "species_444152" ], "modifiers": [ [ "species_10524590", "catalyst" ] ], "additional_components": [ "species_351601", "species_209794", "species_380585", "species_390899", "species_209789", "species_209789", "species_209794", "species_390899", "species_351601", "species_380585", "WBGene00000295" ] }, "reaction_10524580": { "compartment": "compartment_876", "id": "reaction_10524580", "reactome": "R-CEL-443997", "name": "SLC6A2 cotransports NAd, Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_374935", "species_74113" ], "products": [ "species_209789", "species_83910" ], "modifiers": [ [ "species_10524577", "catalyst" ] ], "additional_components": [ "WBGene00000934" ] }, "reaction_10518791": { "compartment": "compartment_876", "id": "reaction_10518791", "reactome": "R-CEL-374896", "name": "Uptake of Noradrenaline", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_374935" ], "products": [ "species_209789" ], "modifiers": [ [ "species_10518786", "catalyst" ] ], "additional_components": [ "WBGene00003987" ] }, "reaction_10524651": { "compartment": "compartment_984", "id": "reaction_10524651", "reactome": "R-CEL-444433", "name": "Cho transports from the extracellular space to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_264638" ], "products": [ "species_264618" ], "modifiers": [ [ "species_10524644", "catalyst" ] ], "additional_components": [ "WBGene00018037" ] }, "reaction_10527456": { "compartment": "compartment_876", "id": "reaction_10527456", "reactome": "R-CEL-549304", "name": "OCT3 mediates renal clearance of organic cations", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_549326" ], "products": [ "species_549255" ], "modifiers": [ [ "species_10527453", "catalyst" ] ], "additional_components": [ "CHEBI:8428", "CHEBI:46020", "CHEBI:42820", "CHEBI:47499", "CHEBI:47781", "CHEBI:641", "CHEBI:46631", "CHEBI:47781", "CHEBI:8428", "CHEBI:42820", "CHEBI:47499", "CHEBI:641", "CHEBI:46020", "CHEBI:46631", "WBGene00003987" ] }, "reaction_10527408": { "compartment": "compartment_876", "id": "reaction_10527408", "reactome": "R-CEL-549241", "name": "SLC22A4 cotransports ERGT, Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_549261", "species_74113" ], "products": [ "species_83910", "species_549260" ], "modifiers": [ [ "species_10527400", "catalyst" ], [ "species_10527406", "inhibitor" ] ], "additional_components": [ "Q4PIX1", "WBGene00044455", "Q9BKR9", "WBGene00044455", "Q9U539", "WBGene00003842", "Q9UAW9", "WBGene00044455", "A0A0K3AWD3", "WBGene00044455", "A0A238UKL7", "WBGene00044455", "G5EEI9", "WBGene00044455", "G5EGL6", "WBGene00044455", "O18247", "WBGene00044455", "P46499", "WBGene00044455", "Q09617", "WBGene00044455", "Q18613", "WBGene00044455", "Q18655", "WBGene00044455", "Q18795", "WBGene00008271", "Q23501", "WBGene00003843", "WBGene00004393" ] }, "reaction_10527537": { "compartment": "compartment_876", "id": "reaction_10527537", "reactome": "R-CEL-597628", "name": "SLC22A18 exchanges extracellular organic cations for cytosolic H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_597604", "species_70106" ], "products": [ "species_351626", "species_597623" ], "modifiers": [ [ "species_10527534", "catalyst" ] ], "additional_components": [ "WBGene00008273" ] }, "reaction_10527458": { "compartment": "compartment_876", "id": "reaction_10527458", "reactome": "R-CEL-549322", "name": "OCT1 transports organic cations out of hepatic cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_549250" ], "products": [ "species_549264" ], "modifiers": [ [ "species_10518788", "catalyst" ] ], "additional_components": [ "species_351601", "species_209794", "CHEBI:46020", "CHEBI:42820", "CHEBI:6801", "species_549282", "species_6798162", "CHEBI:65133", "CHEBI:15854", "species_141324", "CHEBI:641", "species_390899", "species_353560", "species_209789", "CHEBI:42820", "CHEBI:641", "CHEBI:46020", "species_351601", "CHEBI:6801", "species_209794", "species_141324", "CHEBI:15854", "species_209789", "CHEBI:65133", "species_390899", "species_353560", "species_6798162", "species_549282", "WBGene00003987" ] }, "reaction_10527507": { "compartment": "compartment_876", "id": "reaction_10527507", "reactome": "R-CEL-561072", "name": "OCT3 mediates renal uptake of organic cations", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_549255" ], "products": [ "species_549326" ], "modifiers": [ [ "species_10527453", "catalyst" ] ], "additional_components": [ "CHEBI:47781", "CHEBI:8428", "CHEBI:42820", "CHEBI:47499", "CHEBI:641", "CHEBI:46020", "CHEBI:46631", "CHEBI:8428", "CHEBI:46020", "CHEBI:42820", "CHEBI:47499", "CHEBI:47781", "CHEBI:641", "CHEBI:46631", "WBGene00003987" ] }, "reaction_10527412": { "compartment": "compartment_876", "id": "reaction_10527412", "reactome": "R-CEL-549279", "name": "OCT2 mediates tubular uptake of organic cations in the kidney", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_549237" ], "products": [ "species_549266" ], "modifiers": [ [ "species_10518786", "catalyst" ] ], "additional_components": [ "CHEBI:31941", "CHEBI:16737", "CHEBI:641", "CHEBI:46020", "species_351601", "CHEBI:6801", "species_209794", "species_209789", "CHEBI:65133", "species_351164", "species_390899", "species_6798162", "species_549282", "species_380585", "species_351601", "species_209794", "CHEBI:46020", "CHEBI:6801", "species_549282", "CHEBI:16737", "species_6798162", "CHEBI:65133", "CHEBI:641", "species_380585", "species_351164", "species_390899", "CHEBI:31941", "species_209789", "WBGene00003987" ] }, "reaction_10527494": { "compartment": "compartment_876", "id": "reaction_10527494", "reactome": "R-CEL-561054", "name": "OCT2 mediates tubular secretion of organic cations in the kidney", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_549266" ], "products": [ "species_549237" ], "modifiers": [ [ "species_10518786", "catalyst" ] ], "additional_components": [ "species_351601", "species_209794", "CHEBI:46020", "CHEBI:6801", "species_549282", "CHEBI:16737", "species_6798162", "CHEBI:65133", "CHEBI:641", "species_380585", "species_351164", "species_390899", "CHEBI:31941", "species_209789", "CHEBI:31941", "CHEBI:16737", "CHEBI:641", "CHEBI:46020", "species_351601", "CHEBI:6801", "species_209794", "species_209789", "CHEBI:65133", "species_351164", "species_390899", "species_6798162", "species_549282", "species_380585", "WBGene00003987" ] }, "reaction_10527451": { "compartment": "compartment_876", "id": "reaction_10527451", "reactome": "R-CEL-549297", "name": "SLC22A4, 5,15,16 cotransport CAR, Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_164988", "species_74113" ], "products": [ "species_30235", "species_83910" ], "modifiers": [ [ "species_10527448", "catalyst" ] ], "additional_components": [ "P46499", "WBGene00044455", "Q09617", "WBGene00044455", "Q18613", "WBGene00044455", "Q18655", "WBGene00044455", "Q18795", "WBGene00008271", "Q23501", "WBGene00003843", "Q4PIX1", "WBGene00044455", "Q9BKR9", "WBGene00044455", "Q9U539", "WBGene00003842", "Q9UAW9", "WBGene00044455", "A0A0K3AWD3", "WBGene00044455", "A0A238UKL7", "WBGene00044455", "G5EEI9", "WBGene00044455", "G5EGL6", "WBGene00044455", "O18247", "WBGene00044455" ] }, "reaction_10527343": { "compartment": "compartment_876", "id": "reaction_10527343", "reactome": "R-CEL-549129", "name": "OCT1 transports organic cations into hepatic cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_549264" ], "products": [ "species_549250" ], "modifiers": [ [ "species_10518788", "catalyst" ] ], "additional_components": [ "CHEBI:42820", "CHEBI:641", "CHEBI:46020", "species_351601", "CHEBI:6801", "species_209794", "species_141324", "CHEBI:15854", "species_209789", "CHEBI:65133", "species_390899", "species_353560", "species_6798162", "species_549282", "species_351601", "species_209794", "CHEBI:46020", "CHEBI:42820", "CHEBI:6801", "species_549282", "species_6798162", "CHEBI:65133", "CHEBI:15854", "species_141324", "CHEBI:641", "species_390899", "species_353560", "species_209789", "WBGene00003987" ] }, "reaction_10527505": { "compartment": "compartment_876", "id": "reaction_10527505", "reactome": "R-CEL-561059", "name": "OAT2 and OAT4 mediate transport of sulphate conjugates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29406", "species_561071" ], "products": [ "species_561062", "species_561075" ], "modifiers": [ [ "species_10527502", "catalyst" ] ], "additional_components": [ "species_176496", "species_176501", "species_176501", "species_176496", "Q10917", "WBGene00020701", "Q22686", "WBGene00020701" ] }, "reaction_10527492": { "compartment": "compartment_876", "id": "reaction_10527492", "reactome": "R-CEL-561041", "name": "OAT1-3 transport organic anions with antiport of dicarboxylic acids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29406", "species_561049" ], "products": [ "species_561078", "species_561075" ], "modifiers": [ [ "species_10527489", "catalyst" ] ], "additional_components": [ "CHEBI:104011", "species_561052", "species_561052", "CHEBI:104011", "Q22686", "WBGene00020701", "Q10917", "WBGene00020701" ] }, "reaction_10527516": { "compartment": "compartment_876", "id": "reaction_10527516", "reactome": "R-CEL-561253", "name": "SLC22A12 exchanges extracellular urate for cytosolic LACT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29708", "species_429056" ], "products": [ "species_373863", "species_30034" ], "modifiers": [ [ "species_10527513", "catalyst" ] ], "additional_components": [ "Q10917", "WBGene00020701", "Q22686", "WBGene00020701" ] }, "reaction_10523423": { "compartment": "compartment_876", "id": "reaction_10523423", "reactome": "R-CEL-429594", "name": "SLC5A7 cotransports Cho, Cl-, Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_188972", "species_264638", "species_74113" ], "products": [ "species_264618", "species_83910", "species_352022" ], "modifiers": [ [ "species_10523420", "catalyst" ] ], "additional_components": [ "WBGene00000501" ] }, "reaction_10515237": { "compartment": "compartment_70101", "id": "reaction_10515237", "reactome": "R-CEL-202354", "name": "Translocation of PLC-gamma1 to PIP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10515230", "species_179856" ], "products": [ "species_10515235" ], "modifiers": [], "additional_components": [ "WBGene00004038", "Q22070", "WBGene00004038", "species_179856" ] }, "reaction_10515245": { "compartment": "compartment_70101", "id": "reaction_10515245", "reactome": "R-CEL-202407", "name": "PLC-gamma1 hydrolyses PIP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_179856" ], "products": [ "species_114520", "species_112275" ], "modifiers": [ [ "species_10515242", "catalyst" ] ], "additional_components": [ "WBGene00004038" ] }, "reaction_10529204": { "compartment": "compartment_74700", "id": "reaction_10529204", "reactome": "R-CEL-917841", "name": "Acidification of Tf:TfR1 containing endosome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_70106", "species_113592" ], "products": [ "species_29372", "species_29370", "species_74722" ], "modifiers": [ [ "species_10506845", "catalyst" ] ], "additional_components": [ "G5EGP4", "WBGene00006915", "P30628", "WBGene00006768", "B2MZD0", "WBGene00006916", "G5EEK9", "WBGene00006914", "C0HLB3", "WBGene00006911", "C0HLB4", "WBGene00006912", "G5EDB8", "WBGene00006913", "Q95YD5", "WBGene00016258", "Q20591", "WBGene00009882", "Q9XXU9", "WBGene00006920", "Q22494", "WBGene00020507", "Q23680", "WBGene00006918", "P34462", "WBGene00010130", "Q9XW92", "WBGene00013025", "Q19626", "WBGene00006921", "Q9N5A0", "WBGene00004959", "Q95X44", "WBGene00006917", "P91303", "WBGene00006919", "Q9TYW1", "WBGene00021952" ] }, "reaction_10529221": { "compartment": "compartment_74700", "id": "reaction_10529221", "reactome": "R-CEL-917936", "name": "MCOLN1 transports Fe2+ from endosome lumen to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_917810" ], "products": [ "species_71067" ], "modifiers": [ [ "species_10529218", "catalyst" ] ], "additional_components": [ "WBGene00000846" ] }, "reaction_10543223": { "compartment": "compartment_984", "id": "reaction_10543223", "reactome": "R-CEL-2168886", "name": "Hemopexin binds Hemes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9707310", "species_10543219" ], "products": [ "species_10543221" ], "modifiers": [], "additional_components": [ "species_71185", "Q21182", "WBGene00194737", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "Q21182", "WBGene00194737", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "species_71185" ] }, "reaction_10503456": { "compartment": "compartment_5460", "id": "reaction_10503456", "reactome": "R-CEL-70859", "name": "isobutyryl-CoA + FAD => methacrylyl-CoA + FADH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113596", "species_70851" ], "products": [ "species_70858", "species_31649" ], "modifiers": [ [ "species_10503453", "catalyst" ] ], "additional_components": [ "Q95YB2", "WBGene00017874", "species_113596" ] }, "reaction_10527201": { "compartment": "compartment_70101", "id": "reaction_10527201", "reactome": "R-CEL-508189", "name": "a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29404", "species_508187" ], "products": [ "species_29406", "species_508182" ], "modifiers": [ [ "species_10503361", "catalyst" ] ], "additional_components": [ "CHEBI:28654", "CHEBI:17865", "CHEBI:16530", "CHEBI:57427", "CHEBI:58045", "species_29702", "P54688", "WBGene00001149" ] }, "reaction_10503426": { "compartment": "compartment_5460", "id": "reaction_10503426", "reactome": "R-CEL-70800", "name": "alpha-methylbutyryl-CoA + FAD => tiglyl-CoA + FADH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70718", "species_113596" ], "products": [ "species_70799", "species_31649" ], "modifiers": [ [ "species_10503423", "catalyst" ] ], "additional_components": [ "O44549", "WBGene00019433", "species_113596" ] }, "reaction_10527203": { "compartment": "compartment_5460", "id": "reaction_10527203", "reactome": "R-CEL-508308", "name": "beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O <=> beta-methylcrotonyl-CoA + ATP + CO2 [MCCA]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113548", "species_113581", "species_70772", "species_113521" ], "products": [ "species_70744", "species_29896", "species_113593" ], "modifiers": [ [ "species_10503403", "catalyst" ] ], "additional_components": [ "P34385", "WBGene00303021", "O45430", "WBGene00009319" ] }, "reaction_10503492": { "compartment": "compartment_5460", "id": "reaction_10503492", "reactome": "R-CEL-70893", "name": "methylmalonate semialdehyde + NAD+ + CoA => propionyl-CoA + CO2 + NADH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_113526", "species_30004" ], "products": [ "species_70843", "species_113529", "species_29362", "species_29376" ], "modifiers": [ [ "species_10503489", "catalyst" ] ], "additional_components": [ "WBGene00000114" ] }, "reaction_10556964": { "compartment": "compartment_5460", "id": "reaction_10556964", "reactome": "R-CEL-5693153", "name": "PPM1K dephosphorylates p-BCKDH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10556954", "species_113521" ], "products": [ "species_113548", "species_10503350" ], "modifiers": [ [ "species_10556961", "catalyst" ] ], "additional_components": [ "Q23571", "WBGene00014054", "Q93619", "WBGene00006518", "species_8878387", "O45924", "WBGene00012713", "O17953", "WBGene00010794", "species_113596", "Q23571", "WBGene00014054", "Q93619", "WBGene00006518", "species_8878387", "O45924", "WBGene00012713", "O17953", "WBGene00010794", "species_113596", "species_266099", "G5EEM6", "WBGene00006524" ] }, "reaction_10527205": { "compartment": "compartment_5460", "id": "reaction_10527205", "reactome": "R-CEL-508369", "name": "alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113529", "species_70836", "species_29362" ], "products": [ "species_70829", "species_113526" ], "modifiers": [ [ "species_10503433", "catalyst" ] ], "additional_components": [ "Q19102", "WBGene00000181" ] }, "reaction_10527207": { "compartment": "compartment_5460", "id": "reaction_10527207", "reactome": "R-CEL-508473", "name": "methylmalonyl semialdehyde + NADH + H+ <=> beta-hydroxyisobutyrate + NAD+", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113529", "species_30004", "species_29362" ], "products": [ "species_113526", "species_573404" ], "modifiers": [ [ "species_10503481", "catalyst" ] ], "additional_components": [ "Q9XTI0", "WBGene00007122" ] }, "reaction_10503466": { "compartment": "compartment_5460", "id": "reaction_10503466", "reactome": "R-CEL-70870", "name": "ECHS1 hydrates methacrylyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70858", "species_113521" ], "products": [ "species_71847" ], "modifiers": [ [ "species_10503463", "catalyst" ] ], "additional_components": [ "P34559", "WBGene00001155" ] }, "reaction_10503474": { "compartment": "compartment_5460", "id": "reaction_10503474", "reactome": "R-CEL-70881", "name": "beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71847", "species_113521" ], "products": [ "species_29374", "species_573404" ], "modifiers": [ [ "species_10503471", "catalyst" ] ], "additional_components": [ "WBGene00017301" ] }, "reaction_10503380": { "compartment": "compartment_5460", "id": "reaction_10503380", "reactome": "R-CEL-70724", "name": "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113594", "species_508190" ], "products": [ "species_508181", "species_113552" ], "modifiers": [ [ "species_10503377", "catalyst" ] ], "additional_components": [ "CHEBI:58045", "species_29702", "CHEBI:57427", "CHEBI:16530", "CHEBI:28654", "CHEBI:17865", "P54688", "WBGene00001149", "Q9XXD8", "WBGene00012855" ] }, "reaction_10503446": { "compartment": "compartment_5460", "id": "reaction_10503446", "reactome": "R-CEL-70844", "name": "alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_70836" ], "products": [ "species_70843", "species_113559" ], "modifiers": [ [ "species_10503443", "catalyst" ] ], "additional_components": [ "Q22100", "WBGene00002183" ] }, "reaction_10503416": { "compartment": "compartment_5460", "id": "reaction_10503416", "reactome": "R-CEL-70785", "name": "beta-methylglutaconyl-CoA + H2O <=> beta-hydroxy-beta-methylglutaryl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70772", "species_113521" ], "products": [ "species_70784" ], "modifiers": [ [ "species_10503413", "catalyst" ] ], "additional_components": [ "O45106", "WBGene00001154" ] }, "reaction_10503353": { "compartment": "compartment_5460", "id": "reaction_10503353", "reactome": "R-CEL-70713", "name": "BCKDH transfers CoA group from CoA-SH to BCAAs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_113526", "species_508181" ], "products": [ "species_29362", "species_508261", "species_29376" ], "modifiers": [ [ "species_10503350", "catalyst" ] ], "additional_components": [ "CHEBI:16530", "CHEBI:28654", "CHEBI:17865", "species_70851", "species_70715", "species_70718", "Q23571", "WBGene00014054", "Q93619", "WBGene00006518", "species_8878387", "O45924", "WBGene00012713", "O17953", "WBGene00010794", "species_113596" ] }, "reaction_10503390": { "compartment": "compartment_5460", "id": "reaction_10503390", "reactome": "R-CEL-70745", "name": "isovaleryl-CoA + FAD => beta-methylcrotonyl-CoA + FADH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113596", "species_70715" ], "products": [ "species_70744", "species_31649" ], "modifiers": [ [ "species_10503387", "catalyst" ] ], "additional_components": [ "G5EEH6", "WBGene00015326", "species_113596" ] }, "reaction_10557989": { "compartment": "compartment_7660", "id": "reaction_10557989", "reactome": "R-CEL-6783238", "name": "OTUB1,(OTUB2) binds TP53, UBE2D1, ESR1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10511537", "species_10557985" ], "products": [ "species_10557987" ], "modifiers": [], "additional_components": [ "P35129", "WBGene00002344", "P91853", "WBGene00006732", "Q17720", "WBGene00006717", "Q9XVR6", "WBGene00007718", "Q9XVR6", "WBGene00007718", "P35129", "WBGene00002344", "P91853", "WBGene00006732", "Q17720", "WBGene00006717" ] }, "reaction_10556681": { "compartment": "compartment_70101", "id": "reaction_10556681", "reactome": "R-CEL-5690843", "name": "OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10556669", "species_10556677" ], "products": [ "species_10556679" ], "modifiers": [], "additional_components": [ "Q9XVR6", "WBGene00007718", "Q9XX98", "WBGene00019185", "O76671", "WBGene00019185", "Q22038", "WBGene00004357", "Q9XX98", "WBGene00019185", "O76671", "WBGene00019185", "Q22038", "WBGene00004357", "Q9XVR6", "WBGene00007718" ] }, "reaction_10566184": { "compartment": "compartment_70101", "id": "reaction_10566184", "reactome": "R-CEL-8865182", "name": "OTUD7A hydrolyses K11diUb", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10566176" ], "products": [ "species_10502375" ], "modifiers": [ [ "species_10566181", "catalyst" ] ], "additional_components": [ "P37165", "WBGene00006725", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "WBGene00021733" ] }, "reaction_10554672": { "compartment": "compartment_70101", "id": "reaction_10554672", "reactome": "R-CEL-5665871", "name": "ADRM1 binds 26S proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502572", "species_10554643" ], "products": [ "species_10554645" ], "modifiers": [], "additional_components": [ "P91477", "WBGene00003950", "Q95PZ7", "WBGene00013435", "Q18115", "WBGene00004459", "O62102", "WBGene00003948", "O17071", "WBGene00004504", "Q10920", "WBGene00016623", "P34286", "WBGene00003952", "Q9XTT9", "WBGene00004506", "Q23449", "WBGene00004468", "Q95005", "WBGene00003925", "P46502", "WBGene00004503", "O61792", "WBGene00004464", "O17586", "WBGene00003922", "O76371", "WBGene00004505", "Q20585", "WBGene00004463", "Q95008", "WBGene00003926", "Q18787", "WBGene00004501", "Q20058", "WBGene00009445", "Q9N599", "WBGene00003924", "O16368", "WBGene00004502", "O61742", "WBGene00004466", "Q09583", "WBGene00003928", "Q966I8", "WBGene00003947", "Q04908", "WBGene00004460", "Q9XUV0", "WBGene00003951", "Q27488", "WBGene00003923", "Q9GZH5", "WBGene00004458", "O44156", "WBGene00003927", "Q22253", "WBGene00004465", "O76577", "WBGene00004467", "P90868", "WBGene00003953", "Q19324", "WBGene00004461", "Q17971", "WBGene00007588", "Q23237", "WBGene00003949", "Q20938", "WBGene00004462", "WBGene00016981", "Q09289", "WBGene00016981", "P91477", "WBGene00003950", "Q95PZ7", "WBGene00013435", "Q18115", "WBGene00004459", "O62102", "WBGene00003948", "O17071", "WBGene00004504", "Q10920", "WBGene00016623", "P34286", "WBGene00003952", "Q9XTT9", "WBGene00004506", "Q23449", "WBGene00004468", "Q95005", "WBGene00003925", "P46502", "WBGene00004503", "O61792", "WBGene00004464", "O17586", "WBGene00003922", "O76371", "WBGene00004505", "Q20585", "WBGene00004463", "Q95008", "WBGene00003926", "Q18787", "WBGene00004501", "Q20058", "WBGene00009445", "Q9N599", "WBGene00003924", "O16368", "WBGene00004502", "O61742", "WBGene00004466", "Q09583", "WBGene00003928", "Q966I8", "WBGene00003947", "Q04908", "WBGene00004460", "Q9XUV0", "WBGene00003951", "Q27488", "WBGene00003923", "Q9GZH5", "WBGene00004458", "O44156", "WBGene00003927", "Q22253", "WBGene00004465", "O76577", "WBGene00004467", "P90868", "WBGene00003953", "Q19324", "WBGene00004461", "Q17971", "WBGene00007588", "Q23237", "WBGene00003949", "Q20938", "WBGene00004462" ] }, "reaction_10554649": { "compartment": "compartment_70101", "id": "reaction_10554649", "reactome": "R-CEL-5665854", "name": "ADRM1:26S proteaseome binds UCHL5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10554638", "species_10554645" ], "products": [ "species_10554647" ], "modifiers": [], "additional_components": [ "WBGene00006724", "Q09289", "WBGene00016981", "P91477", "WBGene00003950", "Q95PZ7", "WBGene00013435", "Q18115", "WBGene00004459", "O62102", "WBGene00003948", "O17071", "WBGene00004504", "Q10920", "WBGene00016623", "P34286", "WBGene00003952", "Q9XTT9", "WBGene00004506", "Q23449", "WBGene00004468", "Q95005", "WBGene00003925", "P46502", "WBGene00004503", "O61792", "WBGene00004464", "O17586", "WBGene00003922", "O76371", "WBGene00004505", "Q20585", "WBGene00004463", "Q95008", "WBGene00003926", "Q18787", "WBGene00004501", "Q20058", "WBGene00009445", "Q9N599", "WBGene00003924", "O16368", "WBGene00004502", "O61742", "WBGene00004466", "Q09583", "WBGene00003928", "Q966I8", "WBGene00003947", "Q04908", "WBGene00004460", "Q9XUV0", "WBGene00003951", "Q27488", "WBGene00003923", "Q9GZH5", "WBGene00004458", "O44156", "WBGene00003927", "Q22253", "WBGene00004465", "O76577", "WBGene00004467", "P90868", "WBGene00003953", "Q19324", "WBGene00004461", "Q17971", "WBGene00007588", "Q23237", "WBGene00003949", "Q20938", "WBGene00004462", "Q09289", "WBGene00016981", "P91477", "WBGene00003950", "Q95PZ7", "WBGene00013435", "Q18115", "WBGene00004459", "O62102", "WBGene00003948", "O17071", "WBGene00004504", "Q10920", "WBGene00016623", "P34286", "WBGene00003952", "Q9XTT9", "WBGene00004506", "Q23449", "WBGene00004468", "Q95005", "WBGene00003925", "P46502", "WBGene00004503", "O61792", "WBGene00004464", "O17586", "WBGene00003922", "O76371", "WBGene00004505", "Q20585", "WBGene00004463", "Q95008", "WBGene00003926", "Q18787", "WBGene00004501", "Q20058", "WBGene00009445", "Q9N599", "WBGene00003924", "O16368", "WBGene00004502", "O61742", "WBGene00004466", "Q09583", "WBGene00003928", "Q966I8", "WBGene00003947", "Q04908", "WBGene00004460", "Q9XUV0", "WBGene00003951", "Q27488", "WBGene00003923", "Q9GZH5", "WBGene00004458", "O44156", "WBGene00003927", "Q22253", "WBGene00004465", "O76577", "WBGene00004467", "P90868", "WBGene00003953", "Q19324", "WBGene00004461", "Q17971", "WBGene00007588", "Q23237", "WBGene00003949", "Q20938", "WBGene00004462", "Q09444", "WBGene00006724" ] }, "reaction_10556601": { "compartment": "compartment_70101", "id": "reaction_10556601", "reactome": "R-CEL-5690319", "name": "UCHL1, UCHL3 cleave ubiquitin adducts", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10556596" ], "products": [ "species_1131871", "species_10556598" ], "modifiers": [ [ "species_10556596", "catalyst" ] ], "additional_components": [ "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "P49632", "WBGene00006728", "Q9UAV3", "WBGene00006721", "Q8MNY0", "WBGene00006722", "Q965V9", "WBGene00006723", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "Q9UAV3", "WBGene00006721", "Q8MNY0", "WBGene00006722", "Q965V9", "WBGene00006723", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "P49632", "WBGene00006728", "Q9UAV3", "WBGene00006721", "Q8MNY0", "WBGene00006722", "Q965V9", "WBGene00006723" ] }, "reaction_10556653": { "compartment": "compartment_70101", "id": "reaction_10556653", "reactome": "R-CEL-5690808", "name": "UCHL3, SENP8 cleave NEDD8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10556644" ], "products": [ "species_10556650", "species_10556648" ], "modifiers": [ [ "species_10556644", "catalyst" ] ], "additional_components": [ "Q93725", "WBGene00003587", "Q9UAV3", "WBGene00006721", "Q86FN3", "WBGene00006738", "WBGene00003587", "Q93725", "WBGene00003587", "Q9UAV3", "WBGene00006721", "Q86FN3", "WBGene00006738", "Q93725", "WBGene00003587", "Q9UAV3", "WBGene00006721", "Q86FN3", "WBGene00006738" ] }, "reaction_10556465": { "compartment": "compartment_7660", "id": "reaction_10556465", "reactome": "R-CEL-5689950", "name": "USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10556179" ], "products": [ "species_10556462", "species_10556185" ], "modifiers": [ [ "species_10556179", "catalyst" ] ], "additional_components": [ "O16850", "WBGene00000912", "G5EE01", "WBGene00000913", "Q7JKC3", "WBGene00010406", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "P49632", "WBGene00006728", "G5EE01", "WBGene00000913", "O16850", "WBGene00000912", "Q7JKC3", "WBGene00010406", "O16850", "WBGene00000912", "G5EE01", "WBGene00000913", "Q7JKC3", "WBGene00010406" ] }, "reaction_10557760": { "compartment": "compartment_7660", "id": "reaction_10557760", "reactome": "R-CEL-5696960", "name": "USP49 deubiquitinates H2B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10557755" ], "products": [ "species_10502318", "species_10557757" ], "modifiers": [ [ "species_10557755", "catalyst" ] ], "additional_components": [ "Q9GRV2", "WBGene00013506", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "Q9GRV2", "WBGene00013506", "Q9GRV2", "WBGene00013506" ] }, "reaction_10557827": { "compartment": "compartment_70101", "id": "reaction_10557827", "reactome": "R-CEL-6781764", "name": "USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10557820", "species_29356" ], "products": [ "species_10502375", "species_10557824" ], "modifiers": [ [ "species_10557820", "catalyst" ] ], "additional_components": [ "Q8WT44", "WBGene00000874", "V6CJY2", "WBGene00019259", "Q02330", "WBGene00004856", "F5GUE5", "WBGene00000910", "P45896", "WBGene00004857", "Q21733", "WBGene00000904", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "Q8WT44", "WBGene00000874", "V6CJY2", "WBGene00019259", "Q21733", "WBGene00000904", "F5GUE5", "WBGene00000910", "P45896", "WBGene00004857", "Q02330", "WBGene00004856", "Q8WT44", "WBGene00000874", "V6CJY2", "WBGene00019259", "Q02330", "WBGene00004856", "F5GUE5", "WBGene00000910", "P45896", "WBGene00004857", "Q21733", "WBGene00000904" ] }, "reaction_10556130": { "compartment": "compartment_70101", "id": "reaction_10556130", "reactome": "R-CEL-5689539", "name": "ADRM1:26S proteaseome binds USP14", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10556126", "species_10554645" ], "products": [ "species_10556128" ], "modifiers": [], "additional_components": [ "WBGene00006856", "Q09289", "WBGene00016981", "P91477", "WBGene00003950", "Q95PZ7", "WBGene00013435", "Q18115", "WBGene00004459", "O62102", "WBGene00003948", "O17071", "WBGene00004504", "Q10920", "WBGene00016623", "P34286", "WBGene00003952", "Q9XTT9", "WBGene00004506", "Q23449", "WBGene00004468", "Q95005", "WBGene00003925", "P46502", "WBGene00004503", "O61792", "WBGene00004464", "O17586", "WBGene00003922", "O76371", "WBGene00004505", "Q20585", "WBGene00004463", "Q95008", "WBGene00003926", "Q18787", "WBGene00004501", "Q20058", "WBGene00009445", "Q9N599", "WBGene00003924", "O16368", "WBGene00004502", "O61742", "WBGene00004466", "Q09583", "WBGene00003928", "Q966I8", "WBGene00003947", "Q04908", "WBGene00004460", "Q9XUV0", "WBGene00003951", "Q27488", "WBGene00003923", "Q9GZH5", "WBGene00004458", "O44156", "WBGene00003927", "Q22253", "WBGene00004465", "O76577", "WBGene00004467", "P90868", "WBGene00003953", "Q19324", "WBGene00004461", "Q17971", "WBGene00007588", "Q23237", "WBGene00003949", "Q20938", "WBGene00004462", "Q09289", "WBGene00016981", "P91477", "WBGene00003950", "Q95PZ7", "WBGene00013435", "Q18115", "WBGene00004459", "O62102", "WBGene00003948", "O17071", "WBGene00004504", "Q10920", "WBGene00016623", "P34286", "WBGene00003952", "Q9XTT9", "WBGene00004506", "Q23449", "WBGene00004468", "Q95005", "WBGene00003925", "P46502", "WBGene00004503", "O61792", "WBGene00004464", "O17586", "WBGene00003922", "O76371", "WBGene00004505", "Q20585", "WBGene00004463", "Q95008", "WBGene00003926", "Q18787", "WBGene00004501", "Q20058", "WBGene00009445", "Q9N599", "WBGene00003924", "O16368", "WBGene00004502", "O61742", "WBGene00004466", "Q09583", "WBGene00003928", "Q966I8", "WBGene00003947", "Q04908", "WBGene00004460", "Q9XUV0", "WBGene00003951", "Q27488", "WBGene00003923", "Q9GZH5", "WBGene00004458", "O44156", "WBGene00003927", "Q22253", "WBGene00004465", "O76577", "WBGene00004467", "P90868", "WBGene00003953", "Q19324", "WBGene00004461", "Q17971", "WBGene00007588", "Q23237", "WBGene00003949", "Q20938", "WBGene00004462", "Q17361", "WBGene00006856" ] }, "reaction_10557670": { "compartment": "compartment_7660", "id": "reaction_10557670", "reactome": "R-CEL-5696605", "name": "USP12, USP26 deubiquitinate AR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10557665" ], "products": [ "species_10556462", "species_10557667" ], "modifiers": [ [ "species_10557665", "catalyst" ] ], "additional_components": [ "P34547", "WBGene00011216", "D9N129", "WBGene00007428", "Q20059", "WBGene00009441", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "P49632", "WBGene00006728", "P34547", "WBGene00011216", "D9N129", "WBGene00007428", "Q20059", "WBGene00009441", "P34547", "WBGene00011216", "D9N129", "WBGene00007428", "Q20059", "WBGene00009441" ] }, "reaction_10557721": { "compartment": "compartment_7660", "id": "reaction_10557721", "reactome": "R-CEL-5696958", "name": "USP44 deubiquitinates CDC20", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10557716" ], "products": [ "species_10556462", "species_10557718" ], "modifiers": [ [ "species_10557716", "catalyst" ] ], "additional_components": [ "Q9GRV2", "WBGene00013506", "Q09373", "WBGene00001511", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "P49632", "WBGene00006728", "Q9GRV2", "WBGene00013506", "Q09373", "WBGene00001511", "Q9GRV2", "WBGene00013506", "Q09373", "WBGene00001511" ] }, "reaction_10557836": { "compartment": "compartment_70101", "id": "reaction_10557836", "reactome": "R-CEL-6781797", "name": "USP19 binds HIF1A,BIRC2,BIRC3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10532174", "species_10557832" ], "products": [ "species_10557834" ], "modifiers": [], "additional_components": [ "WBGene00001851", "WBGene00008441", "G5EBW2", "WBGene00008441", "G5EGD2", "WBGene00001851" ] }, "reaction_10557788": { "compartment": "compartment_7660", "id": "reaction_10557788", "reactome": "R-CEL-5697009", "name": "USP37:RUVLB1:PSMC5 deubiquitinates CCNA1,CCNA2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10557781" ], "products": [ "species_10556462", "species_10557785" ], "modifiers": [ [ "species_10557781", "catalyst" ] ], "additional_components": [ "Q9XTT9", "WBGene00004506", "O17607", "WBGene00007784", "P34638", "WBGene00000863", "Q22319", "WBGene00011591", "Q9U2M5", "WBGene00000870", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "P49632", "WBGene00006728", "Q9XTT9", "WBGene00004506", "O17607", "WBGene00007784", "P34638", "WBGene00000863", "Q22319", "WBGene00011591", "Q9U2M5", "WBGene00000870", "Q9XTT9", "WBGene00004506", "O17607", "WBGene00007784", "P34638", "WBGene00000863", "Q22319", "WBGene00011591", "Q9U2M5", "WBGene00000870" ] }, "reaction_10557678": { "compartment": "compartment_70101", "id": "reaction_10557678", "reactome": "R-CEL-5696627", "name": "CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10557675" ], "products": [ "species_10511035", "species_10511040" ], "modifiers": [ [ "species_10557675", "catalyst" ] ], "additional_components": [ "Q7JMS4", "WBGene00009594", "Q9NAC7", "WBGene00013149", "P37165", "WBGene00006725", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "WBGene00013149", "Q7JMS4", "WBGene00009594", "Q9NAC7", "WBGene00013149" ] }, "reaction_10556096": { "compartment": "compartment_7660", "id": "reaction_10556096", "reactome": "R-CEL-5688834", "name": "ATXN3 binds VCP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10554396", "species_10556072" ], "products": [ "species_10556094" ], "modifiers": [], "additional_components": [ "P54812", "WBGene00008053", "WBGene00006446", "O17850", "WBGene00006446", "P54812", "WBGene00008053" ] }, "reaction_10556092": { "compartment": "compartment_70101", "id": "reaction_10556092", "reactome": "R-CEL-5688797", "name": "ATXN3 family cleave Ub chains", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10511035" ], "products": [ "species_10511035", "species_10511033" ], "modifiers": [ [ "species_10556089", "catalyst" ] ], "additional_components": [ "P37165", "WBGene00006725", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "Q8IAA2", "WBGene00022190", "O17850", "WBGene00006446" ] }, "reaction_10556076": { "compartment": "compartment_7660", "id": "reaction_10556076", "reactome": "R-CEL-5688786", "name": "ATXN3 binds RAD23", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10556072", "species_10556065" ], "products": [ "species_10556074" ], "modifiers": [], "additional_components": [ "WBGene00006446", "WBGene00013924", "Q23451", "WBGene00013924", "O17850", "WBGene00006446" ] }, "reaction_10520355": { "compartment": "compartment_7660", "id": "reaction_10520355", "reactome": "R-CEL-382096", "name": "Formation of NR-NCOR Corepressor Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10517933", "species_10519526" ], "products": [ "species_10520353" ], "modifiers": [], "additional_components": [ "WBGene00001565", "P41830", "WBGene00004786", "Q10902", "WBGene00003601", "Q20765", "WBGene00003606", "Q9XUK7", "WBGene00003675", "G5EDJ0", "WBGene00001400", "Q9XVV3", "WBGene00003657", "Q94407", "WBGene00003638", "Q9XYB7", "WBGene00003607", "G5EFF5", "WBGene00000908", "P41829", "WBGene00003605", "Q9U2R6", "WBGene00003681", "Q3V5L2", "WBGene00022423", "Q19345", "WBGene00003623", "G5ED17", "WBGene00010427", "G5ECR9", "WBGene00006790", "Q17771", "WBGene00003628", "Q9N2W3", "WBGene00022374", "Q18190", "WBGene00016126", "Q9XTJ4", "WBGene00003602", "Q21104", "WBGene00003629", "P41828", "WBGene00003622", "P41830", "WBGene00004786", "Q10902", "WBGene00003601", "Q20765", "WBGene00003606", "Q9XUK7", "WBGene00003675", "G5EDJ0", "WBGene00001400", "Q9XVV3", "WBGene00003657", "Q94407", "WBGene00003638", "Q9XYB7", "WBGene00003607", "G5EFF5", "WBGene00000908", "P41829", "WBGene00003605", "Q9U2R6", "WBGene00003681", "Q3V5L2", "WBGene00022423", "Q19345", "WBGene00003623", "G5ED17", "WBGene00010427", "G5ECR9", "WBGene00006790", "Q17771", "WBGene00003628", "Q9N2W3", "WBGene00022374", "Q18190", "WBGene00016126", "Q9XTJ4", "WBGene00003602", "Q21104", "WBGene00003629", "P41828", "WBGene00003622", "P34333", "WBGene00001565" ] }, "reaction_10564209": { "compartment": "compartment_70101", "id": "reaction_10564209", "reactome": "R-CEL-6814096", "name": "ARL1:GTP binds SCOC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10564205", "species_10564157" ], "products": [ "species_10564207" ], "modifiers": [], "additional_components": [ "WBGene00006802", "Q20758", "WBGene00000187", "species_29438", "Q20758", "WBGene00000187", "species_29438", "A7LPF8", "WBGene00006802" ] }, "reaction_10564165": { "compartment": "compartment_263163", "id": "reaction_10564165", "reactome": "R-CEL-6814086", "name": "ARFRP1 recruits ARL1 to the TGN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10564157", "species_10564149" ], "products": [ "species_10564163" ], "modifiers": [], "additional_components": [ "Q20758", "WBGene00000187", "species_29438", "Q9N3C8", "WBGene00021841", "species_29438", "Q8I7G0", "WBGene00020193", "species_29438", "Q20758", "WBGene00000187", "Q9N3C8", "WBGene00021841", "Q8I7G0", "WBGene00020193" ] }, "reaction_10564037": { "compartment": "compartment_263163", "id": "reaction_10564037", "reactome": "R-CEL-6811429", "name": "RIC1:RGP1 stimulates nucleotide RAB6 nucleotide exchange", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10564028" ], "products": [ "species_29420", "species_10564034" ], "modifiers": [ [ "species_10564028", "catalyst" ] ], "additional_components": [ "P34213", "WBGene00004269", "Q22782", "WBGene00004270", "species_29420", "Q7YWW8", "WBGene00010815", "Q09417", "WBGene00011071", "P34213", "WBGene00004269", "Q22782", "WBGene00004270", "species_29438", "Q7YWW8", "WBGene00010815", "Q09417", "WBGene00011071", "P34213", "WBGene00004269", "Q22782", "WBGene00004270", "species_29420", "Q7YWW8", "WBGene00010815", "Q09417", "WBGene00011071" ] }, "reaction_10564519": { "compartment": "compartment_263163", "id": "reaction_10564519", "reactome": "R-CEL-8847534", "name": "RAB43 hydrolyses GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10564512" ], "products": [ "species_10564516" ], "modifiers": [ [ "species_10564512", "catalyst" ] ], "additional_components": [ "Q9U2D8", "WBGene00012894", "Q9U1W9", "WBGene00004278", "species_29438", "species_29420", "Q9U1W9", "WBGene00004278", "Q9U2D8", "WBGene00012894", "Q9U2D8", "WBGene00012894", "Q9U1W9", "WBGene00004278", "species_29438" ] }, "reaction_10564422": { "compartment": "compartment_263163", "id": "reaction_10564422", "reactome": "R-CEL-6814676", "name": "SNAPs and NSF hexamer bind cis-SNARE at the TGN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10564418", "species_10557345", "species_10557329" ], "products": [ "species_10564420" ], "modifiers": [], "additional_components": [ "O02495", "WBGene00004897", "Q9TY08", "WBGene00022534", "O18230", "WBGene00013302", "Q18921", "WBGene00017016", "Q94392", "WBGene00003818", "Q94392", "WBGene00003818", "Q18921", "WBGene00017016", "O02495", "WBGene00004897", "Q9TY08", "WBGene00022534", "O18230", "WBGene00013302" ] }, "reaction_10564200": { "compartment": "compartment_70101", "id": "reaction_10564200", "reactome": "R-CEL-6814094", "name": "ARL1:GTP binds ARFIP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10564157", "species_10564196" ], "products": [ "species_10564198" ], "modifiers": [], "additional_components": [ "Q20758", "WBGene00000187", "species_29438", "WBGene00010040", "P34445", "WBGene00010040", "Q20758", "WBGene00000187", "species_29438" ] }, "reaction_10564171": { "compartment": "compartment_263163", "id": "reaction_10564171", "reactome": "R-CEL-6814088", "name": "SYS1 binds AcM-ARFRP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10564139", "species_10564169" ], "products": [ "species_10564149" ], "modifiers": [], "additional_components": [ "WBGene00020193", "Q9N3C8", "WBGene00021841", "species_29438", "Q9N3C8", "WBGene00021841", "species_29438", "Q8I7G0", "WBGene00020193" ] }, "reaction_10564523": { "compartment": "compartment_263163", "id": "reaction_10564523", "reactome": "R-CEL-8847537", "name": "RAB43:GTP binds USP8NL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10564510", "species_10564521" ], "products": [ "species_10564512" ], "modifiers": [], "additional_components": [ "Q9U1W9", "WBGene00004278", "species_29438", "WBGene00012894", "Q9U2D8", "WBGene00012894", "Q9U1W9", "WBGene00004278", "species_29438" ] }, "reaction_10564191": { "compartment": "compartment_263163", "id": "reaction_10564191", "reactome": "R-CEL-6814091", "name": "ARL1 recruits TGN Golgin homodimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10564187", "species_10564163" ], "products": [ "species_10564189" ], "modifiers": [], "additional_components": [ "A0A3P6PCP8", "WBGene00010306", "Q18013", "WBGene00002220", "species_29438", "Q20758", "WBGene00000187", "Q9N3C8", "WBGene00021841", "Q8I7G0", "WBGene00020193", "species_29438", "Q20758", "WBGene00000187", "Q9N3C8", "WBGene00021841", "Q8I7G0", "WBGene00020193", "A0A3P6PCP8", "WBGene00010306", "Q18013", "WBGene00002220" ] }, "reaction_10564030": { "compartment": "compartment_263163", "id": "reaction_10564030", "reactome": "R-CEL-6811428", "name": "RIC1:RGP1 recruits RAB6:GDP to the TGN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10563998", "species_10564010" ], "products": [ "species_10564028" ], "modifiers": [], "additional_components": [ "species_29420", "P34213", "WBGene00004269", "Q22782", "WBGene00004270", "Q7YWW8", "WBGene00010815", "Q09417", "WBGene00011071", "P34213", "WBGene00004269", "Q22782", "WBGene00004270", "species_29420", "Q7YWW8", "WBGene00010815", "Q09417", "WBGene00011071" ] }, "reaction_10546544": { "compartment": "compartment_7660", "id": "reaction_10546544", "reactome": "R-CEL-3209159", "name": "Phosphorylated ERF translocates to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546532" ], "products": [ "species_10546542" ], "modifiers": [], "additional_components": [ "A0A4V0IJZ6", "WBGene00304788", "O44138", "WBGene00016798", "A0A4V0IK77", "WBGene00016865", "G5EDL0", "WBGene00002990", "A0A4V0IJZ6", "WBGene00304788", "A0A4V0IK77", "WBGene00016865", "G5EDL0", "WBGene00002990", "O44138", "WBGene00016798" ] }, "reaction_10508244": { "compartment": "compartment_5460", "id": "reaction_10508244", "reactome": "R-CEL-77321", "name": "3-Oxohexanoyl-CoA+CoA-SH<=>Butanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_77320" ], "products": [ "species_77318", "species_113559" ], "modifiers": [ [ "species_10508211", "catalyst" ] ], "additional_components": [ "P34255", "WBGene00015125", "Q9GYT0", "WBGene00020347" ] }, "reaction_10508246": { "compartment": "compartment_5460", "id": "reaction_10508246", "reactome": "R-CEL-77323", "name": "(S)-Hydroxyhexanoyl-CoA+NAD<=>3-Oxohexanoyl-CoA+NADH+H", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77322", "species_113526" ], "products": [ "species_77320", "species_113529", "species_29362" ], "modifiers": [ [ "species_10508194", "catalyst" ] ], "additional_components": [ "P41938", "WBGene00007129" ] }, "reaction_10508248": { "compartment": "compartment_5460", "id": "reaction_10508248", "reactome": "R-CEL-77325", "name": "trans-Hex-2-enoyl-CoA+H2O<=>(S)-Hydroxyhexanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77324", "species_113521" ], "products": [ "species_77322" ], "modifiers": [ [ "species_10503463", "catalyst" ] ], "additional_components": [ "P34559", "WBGene00001155" ] }, "reaction_10557962": { "compartment": "compartment_7660", "id": "reaction_10557962", "reactome": "R-CEL-6782227", "name": "Ligation of newly synthesized repair patch to incised DNA in TC-NER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10557947" ], "products": [ "species_10557960", "species_10556705" ], "modifiers": [ [ "species_10502732", "catalyst" ] ], "additional_components": [ "Q95Y97", "WBGene00019767", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "P90829", "WBGene00008645", "Q19366", "WBGene00008722", "Q21730", "WBGene00011016", "O02115", "WBGene00003955", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "P34409", "WBGene00017696", "Q19826", "WBGene00017830", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "O02092", "WBGene00018391", "Q9GR61", "WBGene00021347", "Q9N3C9", "WBGene00021845", "Q93338", "WBGene00007971", "Q18963", "WBGene00008403", "Q21554", "WBGene00010890", "Q23457", "WBGene00004320", "Q17392", "WBGene00000839", "P34545", "WBGene00000366", "Q23088", "WBGene00022812", "Q7JKC3", "WBGene00010406", "H2KYV0", "WBGene00016115", "P52652", "WBGene00012000", "Q86D18", "WBGene00010011", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q10051", "WBGene00020423", "Q20716", "WBGene00009966", "Q9U1Q7", "WBGene00001258", "Q9U2S6", "WBGene00000889", "P52009", "WBGene00000877", "P52016", "WBGene00000884", "P91175", "WBGene00016837", "Q22139", "WBGene00011411", "Q19826", "WBGene00017830", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "O02092", "WBGene00018391", "Q9GR61", "WBGene00021347", "Q9N3C9", "WBGene00021845", "Q93338", "WBGene00007971", "Q18963", "WBGene00008403", "Q21554", "WBGene00010890", "Q23457", "WBGene00004320", "Q17392", "WBGene00000839", "P34545", "WBGene00000366", "Q23088", "WBGene00022812", "Q7JKC3", "WBGene00010406", "H2KYV0", "WBGene00016115", "P52652", "WBGene00012000", "Q86D18", "WBGene00010011", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q10051", "WBGene00020423", "Q20716", "WBGene00009966", "Q9U1Q7", "WBGene00001258", "Q9U2S6", "WBGene00000889", "P52009", "WBGene00000877", "P52016", "WBGene00000884", "P91175", "WBGene00016837", "Q22139", "WBGene00011411", "Q95Y97", "WBGene00019767", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "P90829", "WBGene00008645", "Q19366", "WBGene00008722", "Q21730", "WBGene00011016", "O02115", "WBGene00003955", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "P34409", "WBGene00017696", "WBGene00002985" ] }, "reaction_10557950": { "compartment": "compartment_7660", "id": "reaction_10557950", "reactome": "R-CEL-6782208", "name": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30555", "species_10557945" ], "products": [ "species_10557947", "species_113541" ], "modifiers": [ [ "species_10557945", "catalyst" ] ], "additional_components": [ "Q95Y97", "WBGene00019767", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "P90829", "WBGene00008645", "Q19366", "WBGene00008722", "Q21730", "WBGene00011016", "O02115", "WBGene00003955", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "P34409", "WBGene00017696", "Q19826", "WBGene00017830", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "O02092", "WBGene00018391", "Q9GR61", "WBGene00021347", "Q9N3C9", "WBGene00021845", "Q93338", "WBGene00007971", "Q18963", "WBGene00008403", "Q21554", "WBGene00010890", "Q23457", "WBGene00004320", "Q17392", "WBGene00000839", "P34545", "WBGene00000366", "Q23088", "WBGene00022812", "Q7JKC3", "WBGene00010406", "H2KYV0", "WBGene00016115", "P52652", "WBGene00012000", "Q86D18", "WBGene00010011", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q10051", "WBGene00020423", "Q20716", "WBGene00009966", "Q9U1Q7", "WBGene00001258", "Q9U2S6", "WBGene00000889", "P52009", "WBGene00000877", "P52016", "WBGene00000884", "P91175", "WBGene00016837", "Q22139", "WBGene00011411", "Q95Y97", "WBGene00019767", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "P90829", "WBGene00008645", "Q19366", "WBGene00008722", "Q21730", "WBGene00011016", "O02115", "WBGene00003955", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "P34409", "WBGene00017696", "Q19826", "WBGene00017830", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "O02092", "WBGene00018391", "Q9GR61", "WBGene00021347", "Q9N3C9", "WBGene00021845", "Q93338", "WBGene00007971", "Q18963", "WBGene00008403", "Q21554", "WBGene00010890", "Q23457", "WBGene00004320", "Q17392", "WBGene00000839", "P34545", "WBGene00000366", "Q23088", "WBGene00022812", "Q7JKC3", "WBGene00010406", "H2KYV0", "WBGene00016115", "P52652", "WBGene00012000", "Q86D18", "WBGene00010011", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q10051", "WBGene00020423", "Q20716", "WBGene00009966", "Q9U1Q7", "WBGene00001258", "Q9U2S6", "WBGene00000889", "P52009", "WBGene00000877", "P52016", "WBGene00000884", "P91175", "WBGene00016837", "Q22139", "WBGene00011411", "Q95Y97", "WBGene00019767", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "P90829", "WBGene00008645", "Q19366", "WBGene00008722", "Q21730", "WBGene00011016", "O02115", "WBGene00003955", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "P34409", "WBGene00017696", "Q19826", "WBGene00017830", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "O02092", "WBGene00018391", "Q9GR61", "WBGene00021347", "Q9N3C9", "WBGene00021845", "Q93338", "WBGene00007971", "Q18963", "WBGene00008403", "Q21554", "WBGene00010890", "Q23457", "WBGene00004320", "Q17392", "WBGene00000839", "P34545", "WBGene00000366", "Q23088", "WBGene00022812", "Q7JKC3", "WBGene00010406", "H2KYV0", "WBGene00016115", "P52652", "WBGene00012000", "Q86D18", "WBGene00010011", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q10051", "WBGene00020423", "Q20716", "WBGene00009966", "Q9U1Q7", "WBGene00001258", "Q9U2S6", "WBGene00000889", "P52009", "WBGene00000877", "P52016", "WBGene00000884", "P91175", "WBGene00016837", "Q22139", "WBGene00011411" ] }, "reaction_10517125": { "compartment": "compartment_7660", "id": "reaction_10517125", "reactome": "R-CEL-212269", "name": "DNMT1,3A,3B:PRC2 methylates cytosine and histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10517106" ], "products": [ "species_77502", "species_10517122" ], "modifiers": [ [ "species_10517106", "catalyst" ] ], "additional_components": [ "P62784", "WBGene00001875", "K7ZUH9", "WBGene00001914", "Q10453", "WBGene00001945", "Q9GYS1", "WBGene00003224", "O17514", "WBGene00003220", "P90916", "WBGene00003036", "P90917", "WBGene00004312", "Q9GYS1", "WBGene00003224", "O17514", "WBGene00003220", "P90916", "WBGene00003036", "P90917", "WBGene00004312", "P62784", "WBGene00001875", "Q10453", "WBGene00001945", "K7ZUH9", "WBGene00001914", "P62784", "WBGene00001875", "K7ZUH9", "WBGene00001914", "Q10453", "WBGene00001945", "Q9GYS1", "WBGene00003224", "O17514", "WBGene00003220", "P90916", "WBGene00003036", "P90917", "WBGene00004312" ] }, "reaction_10568425": { "compartment": "compartment_7660", "id": "reaction_10568425", "reactome": "R-CEL-8938853", "name": "CDK6 binds RUNX1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10568421", "species_10568419" ], "products": [ "species_10568423" ], "modifiers": [], "additional_components": [ "G5EFQ5", "WBGene00004393", "Q95ZL9", "WBGene00000272", "WBGene00000406", "Q9XTR1", "WBGene00000406", "G5EFQ5", "WBGene00004393", "Q95ZL9", "WBGene00000272" ] }, "reaction_10566203": { "compartment": "compartment_7660", "id": "reaction_10566203", "reactome": "R-CEL-8865320", "name": "CBFB binds RUNX1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10566199", "species_10566197" ], "products": [ "species_10566201" ], "modifiers": [], "additional_components": [ "WBGene00004393", "WBGene00000272", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393" ] }, "reaction_10568429": { "compartment": "compartment_7660", "id": "reaction_10568429", "reactome": "R-CEL-8938887", "name": "PML binds RUNX1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546215", "species_10566199" ], "products": [ "species_10568427" ], "modifiers": [], "additional_components": [ "WBGene00006523", "WBGene00004393", "G5EFQ5", "WBGene00004393", "G5ED20", "WBGene00006523" ] }, "reaction_10567459": { "compartment": "compartment_70101", "id": "reaction_10567459", "reactome": "R-CEL-8876312", "name": "SLC5A12 cotransports Na+ with LACT, PYR, NCA from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8876310", "species_74113" ], "products": [ "species_83910", "species_8876304" ], "modifiers": [ [ "species_10567456", "catalyst" ] ], "additional_components": [ "species_113557", "species_29708", "species_8869604", "species_113557", "species_29708", "species_197230", "WBGene00018716" ] }, "reaction_10553973": { "compartment": "compartment_70101", "id": "reaction_10553973", "reactome": "R-CEL-5627802", "name": "SLC26A4 transports I- from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_209785" ], "products": [ "species_209818" ], "modifiers": [ [ "species_10553970", "catalyst" ] ], "additional_components": [ "Q94225", "WBGene00018283", "G5EC30", "WBGene00012259", "G5EEA7", "WBGene00010788", "G5EED0", "WBGene00016945", "G5EFB2", "WBGene00013963", "O17951", "WBGene00010789", "O45016", "WBGene00020914" ] }, "reaction_10522983": { "compartment": "compartment_876", "id": "reaction_10522983", "reactome": "R-CEL-427666", "name": "SLC26A3,6 exchange Cl- for HCO3-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_188972", "species_111627" ], "products": [ "species_425425", "species_352022" ], "modifiers": [ [ "species_10522980", "catalyst" ] ], "additional_components": [ "Q94225", "WBGene00018283", "G5EC30", "WBGene00012259", "G5EEA7", "WBGene00010788", "G5EED0", "WBGene00016945", "G5EFB2", "WBGene00013963", "O17951", "WBGene00010789", "O45016", "WBGene00020914" ] }, "reaction_10522894": { "compartment": "compartment_876", "id": "reaction_10522894", "reactome": "R-CEL-427570", "name": "Group 3 - Selective Cl- transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_188972" ], "products": [ "species_352022" ], "modifiers": [ [ "species_10522891", "catalyst" ] ], "additional_components": [ "G5EDS5", "WBGene00017464", "G5EFB2", "WBGene00013963", "O17951", "WBGene00010789", "O45016", "WBGene00020914", "Q94225", "WBGene00018283", "G5EC30", "WBGene00012259", "G5EEA7", "WBGene00010788", "G5EED0", "WBGene00016945" ] }, "reaction_10521777": { "compartment": "compartment_876", "id": "reaction_10521777", "reactome": "R-CEL-418309", "name": "ATP2B1-4 transport cytosolic Ca2+ to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74016" ], "products": [ "species_74112" ], "modifiers": [ [ "species_10521774", "catalyst" ] ], "additional_components": [ "Q95XP5", "WBGene00003153", "Q9TYP9", "WBGene00019875", "G5EFR6", "WBGene00003151" ] }, "reaction_10522476": { "compartment": "compartment_876", "id": "reaction_10522476", "reactome": "R-CEL-425661", "name": "SLC8A1,2,3 exchange 3Na+ for Ca2+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74016", "species_74113" ], "products": [ "species_83910", "species_74112" ], "modifiers": [ [ "species_10522473", "catalyst" ], [ "species_10504094", "inhibitor" ] ], "additional_components": [ "G5EF08", "WBGene00003566", "H2KYP2", "WBGene00003567", "Q11083", "WBGene00020378", "P04630", "WBGene00000285", "G5EF37", "WBGene00003934", "A0A2C9C3L3", "WBGene00020378", "Q18136", "WBGene00006861", "Q09665", "WBGene00006583", "O02159", "WBGene00020378", "G5EDZ8", "WBGene00000288", "Q94288", "WBGene00000287", "Q09980", "WBGene00017394", "O16305", "WBGene00000552", "G5EEG0", "WBGene00000286" ] }, "reaction_10521789": { "compartment": "compartment_114521", "id": "reaction_10521789", "reactome": "R-CEL-418365", "name": "ATP2A1-3 transport cytosolic Ca2+ to dense tubular network lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_427899", "species_74016" ], "products": [ "species_70106", "species_139827" ], "modifiers": [ [ "species_10521782", "catalyst" ] ], "additional_components": [ "WBGene00004736" ] }, "reaction_10521026": { "compartment": "compartment_70101", "id": "reaction_10521026", "reactome": "R-CEL-392195", "name": "Gi activation by P2Y purinoceptor 12", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10521021" ], "products": [ "species_10521023", "species_29420" ], "modifiers": [ [ "species_10521021", "catalyst" ] ], "additional_components": [ "species_29420", "O76584", "WBGene00001673", "Q9BIG5", "WBGene00001666", "Q21917", "WBGene00001669", "P91907", "WBGene00001677", "Q93743", "WBGene00001668", "Q20907", "WBGene00001670", "Q9BIG2", "WBGene00001676", "Q20910", "WBGene00001671", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "species_113582", "species_113582", "species_29438", "O76584", "WBGene00001673", "Q9BIG5", "WBGene00001666", "Q21917", "WBGene00001669", "P91907", "WBGene00001677", "Q93743", "WBGene00001668", "Q20907", "WBGene00001670", "Q9BIG2", "WBGene00001676", "Q20910", "WBGene00001671", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "species_29420", "O76584", "WBGene00001673", "Q9BIG5", "WBGene00001666", "Q21917", "WBGene00001669", "P91907", "WBGene00001677", "Q93743", "WBGene00001668", "Q20907", "WBGene00001670", "Q9BIG2", "WBGene00001676", "Q20910", "WBGene00001671", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "species_113582" ] }, "reaction_10516882": { "compartment": "compartment_7660", "id": "reaction_10516882", "reactome": "R-CEL-211178", "name": "Phosphorylated FOXO1A is excluded from the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10514285" ], "products": [ "species_10516880" ], "modifiers": [], "additional_components": [ "WBGene00000912", "WBGene00000912" ] }, "reaction_10516878": { "compartment": "compartment_7660", "id": "reaction_10516878", "reactome": "R-CEL-211164", "name": "AKT phosphorylates FOXO1A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10514274" ], "products": [ "species_113582", "species_10514285" ], "modifiers": [ [ "species_10514266", "catalyst" ] ], "additional_components": [ "WBGene00000912", "WBGene00000912", "G4S4W1", "WBGene00016980", "Q17941", "WBGene00000102", "Q9XTG7", "WBGene00000103" ] }, "reaction_10544176": { "compartment": "compartment_70101", "id": "reaction_10544176", "reactome": "R-CEL-2408524", "name": "Sec is reduced to H2Se by PXLP-K259-SCLY dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5359016", "species_5357697" ], "products": [ "species_5357660", "species_29432", "species_5359011" ], "modifiers": [ [ "species_10544173", "catalyst" ] ], "additional_components": [ "Q19434", "WBGene00017442" ] }, "reaction_10557618": { "compartment": "compartment_5460", "id": "reaction_10557618", "reactome": "R-CEL-5696415", "name": "PXLP-K278-ETNPPL tetramer hydrolyses PETA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5696414", "species_113521" ], "products": [ "species_113548", "species_113532", "species_5693978" ], "modifiers": [ [ "species_10557615", "catalyst" ] ], "additional_components": [ "P91408", "WBGene00020139" ] }, "reaction_10535129": { "compartment": "compartment_12045", "id": "reaction_10535129", "reactome": "R-CEL-1483203", "name": "PA is dephosphorylated to DAG by LPIN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_426755" ], "products": [ "species_29372", "species_1500596" ], "modifiers": [ [ "species_10535126", "catalyst" ] ], "additional_components": [ "species_114632", "Q9XXT5", "WBGene00010425" ] }, "reaction_10535146": { "compartment": "compartment_70101", "id": "reaction_10535146", "reactome": "R-CEL-1483222", "name": "ETA is phosphorylated to PETA by CHK/ETNK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1498751" ], "products": [ "species_29370", "species_428686" ], "modifiers": [ [ "species_10535028", "catalyst" ] ], "additional_components": [ "P46560", "WBGene00000513", "O17610", "WBGene00000509", "Q22820", "WBGene00000515", "P46558", "WBGene00000511", "Q22942", "WBGene00000510", "P46559", "WBGene00000512", "Q9GZF3", "WBGene00000514" ] }, "reaction_10535118": { "compartment": "compartment_12045", "id": "reaction_10535118", "reactome": "R-CEL-1483190", "name": "PETA and CTP are condensed to CDP-ETA by PCY2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428686", "species_110614" ], "products": [ "species_111294", "species_1500603" ], "modifiers": [ [ "species_10535115", "catalyst" ] ], "additional_components": [ "X5LPX5", "WBGene00021352" ] }, "reaction_10534959": { "compartment": "compartment_12045", "id": "reaction_10534959", "reactome": "R-CEL-1482962", "name": "CDP-ETA and DAG are converted to PE by CEPT1/EPT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500603", "species_1500596" ], "products": [ "species_1500581", "species_109395" ], "modifiers": [ [ "species_10534956", "catalyst" ] ], "additional_components": [ "species_114632", "species_266099", "G5EC09", "WBGene00009057", "G5EC25", "WBGene00013024", "O44732", "WBGene00018797" ] }, "reaction_10557283": { "compartment": "compartment_12045", "id": "reaction_10557283", "reactome": "R-CEL-5694413", "name": "SEC4C,D bind GOSR2 and STX5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10515692", "species_10515690", "species_10515696" ], "products": [ "species_10515698" ], "modifiers": [], "additional_components": [ "WBGene00004755", "P41941", "WBGene00007128", "Q20797", "WBGene00006373", "WBGene00004754", "Q9U2Z1", "WBGene00004754", "P41941", "WBGene00007128", "Q20797", "WBGene00006373", "Q19371", "WBGene00004755" ] }, "reaction_10557378": { "compartment": "compartment_12045", "id": "reaction_10557378", "reactome": "R-CEL-5694428", "name": "LMAN family proteins bind glycosylated cargo", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10515814", "species_10515745" ], "products": [ "species_10515816" ], "modifiers": [], "additional_components": [ "A9Z1L1", "WBGene00005648", "Q19651", "WBGene00005649", "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q21810", "WBGene00011102", "P92005", "WBGene00000789", "Q9XWA4", "WBGene00013764", "Q18740", "WBGene00008231", "Q9XXQ7", "WBGene00013764", "G5EGP8", "WBGene00000788", "Q9U2X1", "WBGene00013764", "G5EDE8", "WBGene00002070", "G5EDE8", "WBGene00002070", "A9Z1L1", "WBGene00005648", "Q19651", "WBGene00005649", "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q21810", "WBGene00011102", "P92005", "WBGene00000789", "Q9XWA4", "WBGene00013764", "Q18740", "WBGene00008231", "Q9XXQ7", "WBGene00013764", "G5EGP8", "WBGene00000788", "Q9U2X1", "WBGene00013764" ] }, "reaction_10557287": { "compartment": "compartment_12045", "id": "reaction_10557287", "reactome": "R-CEL-5694415", "name": "SEC24A,B:SEC23A bind SEC22B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10515950", "species_10515624", "species_10515696" ], "products": [ "species_10557285" ], "modifiers": [], "additional_components": [ "WBGene00004756", "WBGene00018853", "WBGene00004754", "Q9U2Z1", "WBGene00004754", "Q94241", "WBGene00018853", "Q23368", "WBGene00004756" ] }, "reaction_10557501": { "compartment": "compartment_12045", "id": "reaction_10557501", "reactome": "R-CEL-5694522", "name": "Inner coat assembly and cargo binding", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10515678", "species_10515818", "species_10515956" ], "products": [ "species_10515820" ], "modifiers": [], "additional_components": [ "Q23445", "WBGene00022678", "species_29438", "Q9U2Z1", "WBGene00004754", "P41941", "WBGene00007128", "Q20797", "WBGene00006373", "Q19371", "WBGene00004755", "G5EDE8", "WBGene00002070", "A9Z1L1", "WBGene00005648", "Q19651", "WBGene00005649", "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q21810", "WBGene00011102", "P92005", "WBGene00000789", "Q9XWA4", "WBGene00013764", "Q18740", "WBGene00008231", "Q9XXQ7", "WBGene00013764", "G5EGP8", "WBGene00000788", "Q9U2X1", "WBGene00013764", "Q22361", "WBGene00011648", "Q10914", "WBGene00001613", "Q21415", "WBGene00001614", "Q8MXV8", "WBGene00001617", "P34299", "WBGene00001612", "Q9U2Z1", "WBGene00004754", "Q19371", "WBGene00004755", "Q23368", "WBGene00004756", "Q23368", "WBGene00004756", "Q19371", "WBGene00004755", "Q9U2Z1", "WBGene00004754", "P41941", "WBGene00007128", "Q20797", "WBGene00006373", "G5EDE8", "WBGene00002070", "A9Z1L1", "WBGene00005648", "Q19651", "WBGene00005649", "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q21810", "WBGene00011102", "P92005", "WBGene00000789", "Q9XWA4", "WBGene00013764", "Q18740", "WBGene00008231", "Q9XXQ7", "WBGene00013764", "G5EGP8", "WBGene00000788", "Q9U2X1", "WBGene00013764", "Q22361", "WBGene00011648", "Q10914", "WBGene00001613", "Q21415", "WBGene00001614", "Q8MXV8", "WBGene00001617", "P34299", "WBGene00001612", "Q23445", "WBGene00022678", "species_29438" ] }, "reaction_10557388": { "compartment": "compartment_12045", "id": "reaction_10557388", "reactome": "R-CEL-5694442", "name": "CNIH2,3 bind GRIA1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10515725", "species_10515703" ], "products": [ "species_10515727" ], "modifiers": [], "additional_components": [ "Q10914", "WBGene00001613", "Q21415", "WBGene00001614", "Q8MXV8", "WBGene00001617", "P34299", "WBGene00001612", "WBGene00011648", "Q22361", "WBGene00011648", "Q10914", "WBGene00001613", "Q21415", "WBGene00001614", "Q8MXV8", "WBGene00001617", "P34299", "WBGene00001612" ] }, "reaction_10557504": { "compartment": "compartment_70101", "id": "reaction_10557504", "reactome": "R-CEL-5694527", "name": "Loss of SAR1B GTPase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10515820" ], "products": [ "species_29372", "species_10515818", "species_10515956", "species_10515940" ], "modifiers": [ [ "species_10515820", "catalyst" ] ], "additional_components": [ "Q23368", "WBGene00004756", "Q19371", "WBGene00004755", "Q9U2Z1", "WBGene00004754", "P41941", "WBGene00007128", "Q20797", "WBGene00006373", "G5EDE8", "WBGene00002070", "A9Z1L1", "WBGene00005648", "Q19651", "WBGene00005649", "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q21810", "WBGene00011102", "P92005", "WBGene00000789", "Q9XWA4", "WBGene00013764", "Q18740", "WBGene00008231", "Q9XXQ7", "WBGene00013764", "G5EGP8", "WBGene00000788", "Q9U2X1", "WBGene00013764", "Q22361", "WBGene00011648", "Q10914", "WBGene00001613", "Q21415", "WBGene00001614", "Q8MXV8", "WBGene00001617", "P34299", "WBGene00001612", "Q23445", "WBGene00022678", "species_29438", "Q9U2Z1", "WBGene00004754", "P41941", "WBGene00007128", "Q20797", "WBGene00006373", "Q19371", "WBGene00004755", "G5EDE8", "WBGene00002070", "A9Z1L1", "WBGene00005648", "Q19651", "WBGene00005649", "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q21810", "WBGene00011102", "P92005", "WBGene00000789", "Q9XWA4", "WBGene00013764", "Q18740", "WBGene00008231", "Q9XXQ7", "WBGene00013764", "G5EGP8", "WBGene00000788", "Q9U2X1", "WBGene00013764", "Q22361", "WBGene00011648", "Q10914", "WBGene00001613", "Q21415", "WBGene00001614", "Q8MXV8", "WBGene00001617", "P34299", "WBGene00001612", "Q9U2Z1", "WBGene00004754", "Q19371", "WBGene00004755", "Q23368", "WBGene00004756", "species_29420", "Q23445", "WBGene00022678", "Q23368", "WBGene00004756", "Q19371", "WBGene00004755", "Q9U2Z1", "WBGene00004754", "P41941", "WBGene00007128", "Q20797", "WBGene00006373", "G5EDE8", "WBGene00002070", "A9Z1L1", "WBGene00005648", "Q19651", "WBGene00005649", "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q21810", "WBGene00011102", "P92005", "WBGene00000789", "Q9XWA4", "WBGene00013764", "Q18740", "WBGene00008231", "Q9XXQ7", "WBGene00013764", "G5EGP8", "WBGene00000788", "Q9U2X1", "WBGene00013764", "Q22361", "WBGene00011648", "Q10914", "WBGene00001613", "Q21415", "WBGene00001614", "Q8MXV8", "WBGene00001617", "P34299", "WBGene00001612", "Q23445", "WBGene00022678", "species_29438" ] }, "reaction_10557376": { "compartment": "compartment_6791047", "id": "reaction_10557376", "reactome": "R-CEL-5694425", "name": "NSF ATPase activity dissociates cis-SNARE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10557371", "species_113592" ], "products": [ "species_10557359", "species_10557357", "species_29372", "species_10557352", "species_10557350", "species_10557367", "species_10557329", "species_10557345" ], "modifiers": [ [ "species_10557371", "catalyst" ] ], "additional_components": [ "Q94392", "WBGene00003818", "Q18921", "WBGene00017016", "G5EEU1", "WBGene00043064", "P41941", "WBGene00007128", "Q20364", "WBGene00009654", "Q20797", "WBGene00006373", "Q94241", "WBGene00018853", "WBGene00006373", "WBGene00009654", "WBGene00007128", "WBGene00043064", "Q94241", "WBGene00018853", "Q94392", "WBGene00003818", "Q18921", "WBGene00017016", "Q94392", "WBGene00003818", "Q18921", "WBGene00017016", "G5EEU1", "WBGene00043064", "P41941", "WBGene00007128", "Q20364", "WBGene00009654", "Q20797", "WBGene00006373", "Q94241", "WBGene00018853" ] }, "reaction_10515938": { "compartment": "compartment_13959", "id": "reaction_10515938", "reactome": "R-CEL-203973", "name": "Vesicle budding", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10515831" ], "products": [ "species_10515935", "species_10515933", "species_29372", "species_10515827", "species_10515648" ], "modifiers": [ [ "species_10515831", "catalyst" ] ], "additional_components": [ "Q94241", "WBGene00018853", "G5EFY6", "WBGene00011338", "Q9N4A7", "WBGene00003806", "H2KZQ8", "WBGene00017419", "P34643", "WBGene00013985", "Q9U1W1", "WBGene00006565", "Q23368", "WBGene00004756", "Q19371", "WBGene00004755", "Q9U2Z1", "WBGene00004754", "P41941", "WBGene00007128", "Q20797", "WBGene00006373", "G5EDE8", "WBGene00002070", "A9Z1L1", "WBGene00005648", "Q19651", "WBGene00005649", "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q21810", "WBGene00011102", "P92005", "WBGene00000789", "Q9XWA4", "WBGene00013764", "Q18740", "WBGene00008231", "Q9XXQ7", "WBGene00013764", "G5EGP8", "WBGene00000788", "Q9U2X1", "WBGene00013764", "Q22361", "WBGene00011648", "Q10914", "WBGene00001613", "Q21415", "WBGene00001614", "Q8MXV8", "WBGene00001617", "P34299", "WBGene00001612", "Q23445", "WBGene00022678", "species_29438", "WBGene00022678", "Q94241", "WBGene00018853", "Q23368", "WBGene00004756", "Q19371", "WBGene00004755", "Q9U2Z1", "WBGene00004754", "Q10914", "WBGene00001613", "Q21415", "WBGene00001614", "Q8MXV8", "WBGene00001617", "P34299", "WBGene00001612", "Q22361", "WBGene00011648", "P41941", "WBGene00007128", "Q20797", "WBGene00006373", "G5EDE8", "WBGene00002070", "Q9U2X1", "WBGene00013764", "Q9XWA4", "WBGene00013764", "Q9XXQ7", "WBGene00013764", "G5EGP8", "WBGene00000788", "P92005", "WBGene00000789", "Q18740", "WBGene00008231", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "A9Z1L1", "WBGene00005648", "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "Q21810", "WBGene00011102", "G5EFY6", "WBGene00011338", "Q9N4A7", "WBGene00003806", "Q9U1W1", "WBGene00006565", "H2KZQ8", "WBGene00017419", "P34643", "WBGene00013985", "Q94241", "WBGene00018853", "G5EFY6", "WBGene00011338", "Q9N4A7", "WBGene00003806", "H2KZQ8", "WBGene00017419", "P34643", "WBGene00013985", "Q9U1W1", "WBGene00006565", "Q23368", "WBGene00004756", "Q19371", "WBGene00004755", "Q9U2Z1", "WBGene00004754", "P41941", "WBGene00007128", "Q20797", "WBGene00006373", "G5EDE8", "WBGene00002070", "A9Z1L1", "WBGene00005648", "Q19651", "WBGene00005649", "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q21810", "WBGene00011102", "P92005", "WBGene00000789", "Q9XWA4", "WBGene00013764", "Q18740", "WBGene00008231", "Q9XXQ7", "WBGene00013764", "G5EGP8", "WBGene00000788", "Q9U2X1", "WBGene00013764", "Q22361", "WBGene00011648", "Q10914", "WBGene00001613", "Q21415", "WBGene00001614", "Q8MXV8", "WBGene00001617", "P34299", "WBGene00001612", "Q23445", "WBGene00022678", "species_29438" ] }, "reaction_10557380": { "compartment": "compartment_13959", "id": "reaction_10557380", "reactome": "R-CEL-5694439", "name": "COPII coat binds TRAPPCII and RAB1:GDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10557214", "species_10557263", "species_10515933" ], "products": [ "species_10557265" ], "modifiers": [], "additional_components": [ "Q9UAQ6", "WBGene00004266", "species_29420", "Q9NA81", "WBGene00013259", "B1GRL5", "WBGene00077643", "G4SNB8", "WBGene00044604", "P34605", "WBGene00014222", "Q93330", "WBGene00007956", "B1V899", "WBGene00022138", "Q9XU81", "WBGene00010699", "O02173", "WBGene00021046", "Q20100", "WBGene00018088", "Q94241", "WBGene00018853", "Q23368", "WBGene00004756", "Q19371", "WBGene00004755", "Q9U2Z1", "WBGene00004754", "Q10914", "WBGene00001613", "Q21415", "WBGene00001614", "Q8MXV8", "WBGene00001617", "P34299", "WBGene00001612", "Q22361", "WBGene00011648", "P41941", "WBGene00007128", "Q20797", "WBGene00006373", "G5EDE8", "WBGene00002070", "Q9U2X1", "WBGene00013764", "Q9XWA4", "WBGene00013764", "Q9XXQ7", "WBGene00013764", "G5EGP8", "WBGene00000788", "P92005", "WBGene00000789", "Q18740", "WBGene00008231", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "A9Z1L1", "WBGene00005648", "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "Q21810", "WBGene00011102", "G5EFY6", "WBGene00011338", "Q9N4A7", "WBGene00003806", "Q94241", "WBGene00018853", "Q23368", "WBGene00004756", "Q19371", "WBGene00004755", "Q9U2Z1", "WBGene00004754", "Q10914", "WBGene00001613", "Q21415", "WBGene00001614", "Q8MXV8", "WBGene00001617", "P34299", "WBGene00001612", "Q22361", "WBGene00011648", "P41941", "WBGene00007128", "Q20797", "WBGene00006373", "G5EDE8", "WBGene00002070", "Q9U2X1", "WBGene00013764", "Q9XWA4", "WBGene00013764", "Q9XXQ7", "WBGene00013764", "G5EGP8", "WBGene00000788", "P92005", "WBGene00000789", "Q18740", "WBGene00008231", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "A9Z1L1", "WBGene00005648", "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "Q21810", "WBGene00011102", "G5EFY6", "WBGene00011338", "Q9N4A7", "WBGene00003806", "Q9NA81", "WBGene00013259", "B1GRL5", "WBGene00077643", "G4SNB8", "WBGene00044604", "P34605", "WBGene00014222", "Q93330", "WBGene00007956", "B1V899", "WBGene00022138", "Q9XU81", "WBGene00010699", "O02173", "WBGene00021046", "Q20100", "WBGene00018088", "Q9UAQ6", "WBGene00004266", "species_29420" ] }, "reaction_10557289": { "compartment": "compartment_12045", "id": "reaction_10557289", "reactome": "R-CEL-5694417", "name": "SEC16 complex binds SAR1B:GTP:SEC23:SEC24", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10515820", "species_10515827", "species_10515648" ], "products": [ "species_10515829" ], "modifiers": [], "additional_components": [ "Q23368", "WBGene00004756", "Q19371", "WBGene00004755", "Q9U2Z1", "WBGene00004754", "P41941", "WBGene00007128", "Q20797", "WBGene00006373", "G5EDE8", "WBGene00002070", "A9Z1L1", "WBGene00005648", "Q19651", "WBGene00005649", "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q21810", "WBGene00011102", "P92005", "WBGene00000789", "Q9XWA4", "WBGene00013764", "Q18740", "WBGene00008231", "Q9XXQ7", "WBGene00013764", "G5EGP8", "WBGene00000788", "Q9U2X1", "WBGene00013764", "Q22361", "WBGene00011648", "Q10914", "WBGene00001613", "Q21415", "WBGene00001614", "Q8MXV8", "WBGene00001617", "P34299", "WBGene00001612", "Q23445", "WBGene00022678", "species_29438", "Q9U1W1", "WBGene00006565", "H2KZQ8", "WBGene00017419", "P34643", "WBGene00013985", "H2KZQ8", "WBGene00017419", "P34643", "WBGene00013985", "Q9U1W1", "WBGene00006565", "Q23368", "WBGene00004756", "Q19371", "WBGene00004755", "Q9U2Z1", "WBGene00004754", "P41941", "WBGene00007128", "Q20797", "WBGene00006373", "G5EDE8", "WBGene00002070", "A9Z1L1", "WBGene00005648", "Q19651", "WBGene00005649", "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q21810", "WBGene00011102", "P92005", "WBGene00000789", "Q9XWA4", "WBGene00013764", "Q18740", "WBGene00008231", "Q9XXQ7", "WBGene00013764", "G5EGP8", "WBGene00000788", "Q9U2X1", "WBGene00013764", "Q22361", "WBGene00011648", "Q10914", "WBGene00001613", "Q21415", "WBGene00001614", "Q8MXV8", "WBGene00001617", "P34299", "WBGene00001612", "Q23445", "WBGene00022678", "species_29438" ] }, "reaction_10515948": { "compartment": "compartment_70101", "id": "reaction_10515948", "reactome": "R-CEL-203977", "name": "SAR1 Activation And Membrane Binding", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10515940" ], "products": [ "species_10515678", "species_29420" ], "modifiers": [ [ "species_10515945", "catalyst" ] ], "additional_components": [ "species_29420", "Q23445", "WBGene00022678", "Q23445", "WBGene00022678", "species_29438", "WBGene00010496" ] }, "reaction_10564493": { "compartment": "compartment_6791047", "id": "reaction_10564493", "reactome": "R-CEL-6814831", "name": "TBC1D20 binds RAB1:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10564489", "species_10563177" ], "products": [ "species_10564491" ], "modifiers": [], "additional_components": [ "WBGene00013196", "Q9UAQ6", "WBGene00004266", "species_29438", "Q9UAQ6", "WBGene00004266", "species_29438", "Q9XWI2", "WBGene00013196" ] }, "reaction_10564496": { "compartment": "compartment_6791047", "id": "reaction_10564496", "reactome": "R-CEL-6814833", "name": "TBC1D20 stimulates GTPase activity of RAB1, resulting in hydrolysis of GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10564491" ], "products": [ "species_10557214", "species_10564489" ], "modifiers": [ [ "species_10564491", "catalyst" ] ], "additional_components": [ "Q9UAQ6", "WBGene00004266", "species_29438", "Q9XWI2", "WBGene00013196", "Q9UAQ6", "WBGene00004266", "species_29420", "WBGene00013196", "Q9UAQ6", "WBGene00004266", "species_29438", "Q9XWI2", "WBGene00013196" ] }, "reaction_10557460": { "compartment": "compartment_6791047", "id": "reaction_10557460", "reactome": "R-CEL-5694446", "name": "BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10557386", "species_10557361" ], "products": [ "species_10557295", "species_10557369", "species_10557302", "species_10557458" ], "modifiers": [], "additional_components": [ "Q94241", "WBGene00018853", "G5EGG0", "WBGene00010713", "Q10914", "WBGene00001613", "Q21415", "WBGene00001614", "Q8MXV8", "WBGene00001617", "P34299", "WBGene00001612", "Q22361", "WBGene00011648", "Q9U2Z1", "WBGene00004754", "P41941", "WBGene00007128", "Q20797", "WBGene00006373", "Q19371", "WBGene00004755", "G5EDE8", "WBGene00002070", "Q9U2X1", "WBGene00013764", "Q9XWA4", "WBGene00013764", "Q9XXQ7", "WBGene00013764", "G5EGP8", "WBGene00000788", "P92005", "WBGene00000789", "Q18740", "WBGene00008231", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "A9Z1L1", "WBGene00005648", "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "Q21810", "WBGene00011102", "Q19989", "WBGene00018017", "Q9N3Y1", "WBGene00021536", "G5EEU1", "WBGene00043064", "P41941", "WBGene00007128", "Q20364", "WBGene00009654", "Q20797", "WBGene00006373", "Q19989", "WBGene00018017", "Q9N3Y1", "WBGene00021536", "G5EEU1", "WBGene00043064", "P41941", "WBGene00007128", "Q20364", "WBGene00009654", "Q20797", "WBGene00006373", "Q94241", "WBGene00018853", "G5EGG0", "WBGene00010713", "Q22361", "WBGene00011648", "P34299", "WBGene00001612", "Q10914", "WBGene00001613", "Q21415", "WBGene00001614", "Q8MXV8", "WBGene00001617", "Q9U2Z1", "WBGene00004754", "P41941", "WBGene00007128", "Q20797", "WBGene00006373", "Q19371", "WBGene00004755", "Q21810", "WBGene00011102", "G5EGP8", "WBGene00000788", "P92005", "WBGene00000789", "Q18740", "WBGene00008231", "Q9U2X1", "WBGene00013764", "Q9XWA4", "WBGene00013764", "Q9XXQ7", "WBGene00013764", "A9Z1L1", "WBGene00005648", "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "G5EDE8", "WBGene00002070" ] }, "reaction_10557272": { "compartment": "compartment_13959", "id": "reaction_10557272", "reactome": "R-CEL-5694409", "name": "Nucleotide exchange on RAB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10557265" ], "products": [ "species_29420", "species_10557269" ], "modifiers": [ [ "species_10557265", "catalyst" ] ], "additional_components": [ "Q94241", "WBGene00018853", "Q23368", "WBGene00004756", "Q19371", "WBGene00004755", "Q9U2Z1", "WBGene00004754", "Q10914", "WBGene00001613", "Q21415", "WBGene00001614", "Q8MXV8", "WBGene00001617", "P34299", "WBGene00001612", "Q22361", "WBGene00011648", "P41941", "WBGene00007128", "Q20797", "WBGene00006373", "G5EDE8", "WBGene00002070", "Q9U2X1", "WBGene00013764", "Q9XWA4", "WBGene00013764", "Q9XXQ7", "WBGene00013764", "G5EGP8", "WBGene00000788", "P92005", "WBGene00000789", "Q18740", "WBGene00008231", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "A9Z1L1", "WBGene00005648", "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "Q21810", "WBGene00011102", "G5EFY6", "WBGene00011338", "Q9N4A7", "WBGene00003806", "Q9NA81", "WBGene00013259", "B1GRL5", "WBGene00077643", "G4SNB8", "WBGene00044604", "P34605", "WBGene00014222", "Q93330", "WBGene00007956", "B1V899", "WBGene00022138", "Q9XU81", "WBGene00010699", "O02173", "WBGene00021046", "Q20100", "WBGene00018088", "Q9UAQ6", "WBGene00004266", "species_29420", "Q9UAQ6", "WBGene00004266", "species_29438", "Q94241", "WBGene00018853", "Q23368", "WBGene00004756", "Q19371", "WBGene00004755", "Q9U2Z1", "WBGene00004754", "Q10914", "WBGene00001613", "Q21415", "WBGene00001614", "Q8MXV8", "WBGene00001617", "P34299", "WBGene00001612", "Q22361", "WBGene00011648", "P41941", "WBGene00007128", "Q20797", "WBGene00006373", "G5EDE8", "WBGene00002070", "Q9U2X1", "WBGene00013764", "Q9XWA4", "WBGene00013764", "Q9XXQ7", "WBGene00013764", "G5EGP8", "WBGene00000788", "P92005", "WBGene00000789", "Q18740", "WBGene00008231", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "A9Z1L1", "WBGene00005648", "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "Q21810", "WBGene00011102", "G5EFY6", "WBGene00011338", "Q9N4A7", "WBGene00003806", "Q9NA81", "WBGene00013259", "B1GRL5", "WBGene00077643", "G4SNB8", "WBGene00044604", "P34605", "WBGene00014222", "Q93330", "WBGene00007956", "B1V899", "WBGene00022138", "Q9XU81", "WBGene00010699", "O02173", "WBGene00021046", "Q20100", "WBGene00018088", "Q94241", "WBGene00018853", "Q23368", "WBGene00004756", "Q19371", "WBGene00004755", "Q9U2Z1", "WBGene00004754", "Q10914", "WBGene00001613", "Q21415", "WBGene00001614", "Q8MXV8", "WBGene00001617", "P34299", "WBGene00001612", "Q22361", "WBGene00011648", "P41941", "WBGene00007128", "Q20797", "WBGene00006373", "G5EDE8", "WBGene00002070", "Q9U2X1", "WBGene00013764", "Q9XWA4", "WBGene00013764", "Q9XXQ7", "WBGene00013764", "G5EGP8", "WBGene00000788", "P92005", "WBGene00000789", "Q18740", "WBGene00008231", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "A9Z1L1", "WBGene00005648", "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "Q21810", "WBGene00011102", "G5EFY6", "WBGene00011338", "Q9N4A7", "WBGene00003806", "Q9NA81", "WBGene00013259", "B1GRL5", "WBGene00077643", "G4SNB8", "WBGene00044604", "P34605", "WBGene00014222", "Q93330", "WBGene00007956", "B1V899", "WBGene00022138", "Q9XU81", "WBGene00010699", "O02173", "WBGene00021046", "Q20100", "WBGene00018088", "Q9UAQ6", "WBGene00004266", "species_29420" ] }, "reaction_10557373": { "compartment": "compartment_6791047", "id": "reaction_10557373", "reactome": "R-CEL-5694423", "name": "NSF and SNAPs bind cis-SNARE complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10557369", "species_10557345", "species_10557329" ], "products": [ "species_10557371" ], "modifiers": [], "additional_components": [ "G5EEU1", "WBGene00043064", "P41941", "WBGene00007128", "Q20364", "WBGene00009654", "Q20797", "WBGene00006373", "Q94241", "WBGene00018853", "Q18921", "WBGene00017016", "Q94392", "WBGene00003818", "Q94392", "WBGene00003818", "Q18921", "WBGene00017016", "G5EEU1", "WBGene00043064", "P41941", "WBGene00007128", "Q20364", "WBGene00009654", "Q20797", "WBGene00006373", "Q94241", "WBGene00018853" ] }, "reaction_10557310": { "compartment": "compartment_20699", "id": "reaction_10557310", "reactome": "R-CEL-5694418", "name": "RAB1:GTP binds USO1 and GORASP1:GOLGA2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10557295", "species_10557302", "species_10557269" ], "products": [ "species_10557308" ], "modifiers": [], "additional_components": [ "Q19989", "WBGene00018017", "Q9N3Y1", "WBGene00021536", "G5EGG0", "WBGene00010713", "Q9UAQ6", "WBGene00004266", "species_29438", "Q94241", "WBGene00018853", "Q23368", "WBGene00004756", "Q19371", "WBGene00004755", "Q9U2Z1", "WBGene00004754", "Q10914", "WBGene00001613", "Q21415", "WBGene00001614", "Q8MXV8", "WBGene00001617", "P34299", "WBGene00001612", "Q22361", "WBGene00011648", "P41941", "WBGene00007128", "Q20797", "WBGene00006373", "G5EDE8", "WBGene00002070", "Q9U2X1", "WBGene00013764", "Q9XWA4", "WBGene00013764", "Q9XXQ7", "WBGene00013764", "G5EGP8", "WBGene00000788", "P92005", "WBGene00000789", "Q18740", "WBGene00008231", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "A9Z1L1", "WBGene00005648", "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "Q21810", "WBGene00011102", "G5EFY6", "WBGene00011338", "Q9N4A7", "WBGene00003806", "Q9NA81", "WBGene00013259", "B1GRL5", "WBGene00077643", "G4SNB8", "WBGene00044604", "P34605", "WBGene00014222", "Q93330", "WBGene00007956", "B1V899", "WBGene00022138", "Q9XU81", "WBGene00010699", "O02173", "WBGene00021046", "Q20100", "WBGene00018088", "Q9UAQ6", "WBGene00004266", "species_29438", "Q94241", "WBGene00018853", "Q23368", "WBGene00004756", "Q19371", "WBGene00004755", "Q9U2Z1", "WBGene00004754", "Q10914", "WBGene00001613", "Q21415", "WBGene00001614", "Q8MXV8", "WBGene00001617", "P34299", "WBGene00001612", "Q22361", "WBGene00011648", "P41941", "WBGene00007128", "Q20797", "WBGene00006373", "G5EDE8", "WBGene00002070", "Q9U2X1", "WBGene00013764", "Q9XWA4", "WBGene00013764", "Q9XXQ7", "WBGene00013764", "G5EGP8", "WBGene00000788", "P92005", "WBGene00000789", "Q18740", "WBGene00008231", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "A9Z1L1", "WBGene00005648", "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "Q21810", "WBGene00011102", "G5EFY6", "WBGene00011338", "Q9N4A7", "WBGene00003806", "Q9NA81", "WBGene00013259", "B1GRL5", "WBGene00077643", "G4SNB8", "WBGene00044604", "P34605", "WBGene00014222", "Q93330", "WBGene00007956", "B1V899", "WBGene00022138", "Q9XU81", "WBGene00010699", "O02173", "WBGene00021046", "Q20100", "WBGene00018088", "G5EGG0", "WBGene00010713", "Q19989", "WBGene00018017", "Q9N3Y1", "WBGene00021536" ] }, "reaction_10521505": { "compartment": "compartment_876", "id": "reaction_10521505", "reactome": "R-CEL-400071", "name": "Alpha-2A,alpha-2C Adrenergic Receptors bind adrenaline or noradrenaline", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_390627", "species_10519747" ], "products": [ "species_10519749" ], "modifiers": [], "additional_components": [ "species_209794", "species_209789", "O02213", "WBGene00004777", "Q19084", "WBGene00017157", "O02213", "WBGene00004777", "Q19084", "WBGene00017157", "species_209794", "species_209789" ] }, "reaction_10521511": { "compartment": "compartment_876", "id": "reaction_10521511", "reactome": "R-CEL-400092", "name": "Alpha-2A,alpha-2C Adrenergic Receptors activate Gi.Go heterotrimeric G proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10521509" ], "products": [ "species_10521501", "species_29420" ], "modifiers": [ [ "species_10519749", "catalyst" ] ], "additional_components": [ "species_29420", "species_29438", "O02213", "WBGene00004777", "Q19084", "WBGene00017157", "species_209794", "species_209789" ] }, "reaction_10521518": { "compartment": "compartment_876", "id": "reaction_10521518", "reactome": "R-CEL-400097", "name": "G-beta:G-gamma inhibits Adenylate cyclase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10521499", "species_10521514" ], "products": [ "species_10521516" ], "modifiers": [], "additional_components": [] }, "reaction_10521503": { "compartment": "compartment_876", "id": "reaction_10521503", "reactome": "R-CEL-400037", "name": "Gi,Go Heterotrimeric G-protein complex dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10521501" ], "products": [ "species_10521499", "species_10521493" ], "modifiers": [], "additional_components": [ "species_29438", "species_29438" ] }, "reaction_10571830": { "compartment": "compartment_17963", "id": "reaction_10571830", "reactome": "R-CEL-9036987", "name": "FUT2 transfers Fuc to Type 1 chains to form H antigen-sec", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9036984", "species_205683" ], "products": [ "species_205689", "species_9037036" ], "modifiers": [ [ "species_10571827", "catalyst" ] ], "additional_components": [ "WBGene00015019" ] }, "reaction_10571804": { "compartment": "compartment_17963", "id": "reaction_10571804", "reactome": "R-CEL-9033949", "name": "FUT1 transfers Fuc to Type 2 chains to form H antigen-RBC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9033790", "species_205683" ], "products": [ "species_205689", "species_9033793" ], "modifiers": [ [ "species_10571801", "catalyst" ] ], "additional_components": [ "WBGene00015019" ] }, "reaction_10563778": { "compartment": "compartment_7660", "id": "reaction_10563778", "reactome": "R-CEL-6810238", "name": "RNA polymerase II binds initiation factors at promoter of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10504431", "species_10563743" ], "products": [ "species_10563741" ], "modifiers": [], "additional_components": [ "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "G5EG49", "WBGene00013998", "G5EG47", "WBGene00010054", "O44625", "WBGene00004136", "Q9NEX2", "WBGene00013736", "Q9TVL3", "WBGene00000410", "P34424", "WBGene00000508", "P34425", "WBGene00000507", "O17869", "WBGene00009650", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "O16991", "WBGene00006648", "Q9XW26", "WBGene00012735", "P91868", "WBGene00001568", "Q17694", "WBGene00015513", "G5EFV5", "WBGene00000408", "Q17957", "WBGene00006397", "Q9GZI6", "WBGene00006387", "Q7YTH5", "WBGene00006390", "G5EF68", "WBGene00006386", "O45784", "WBGene00006391", "Q20361", "WBGene00006395", "P32085", "WBGene00006542", "Q9XW26", "WBGene00012735", "P91868", "WBGene00001568", "Q17694", "WBGene00015513", "G5EG49", "WBGene00013998", "G5EG47", "WBGene00010054", "Q9TVL3", "WBGene00000410", "P34424", "WBGene00000508", "P34425", "WBGene00000507", "O17869", "WBGene00009650", "O44625", "WBGene00004136", "Q9NEX2", "WBGene00013736", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "O16991", "WBGene00006648", "G5EFV5", "WBGene00000408", "Q17957", "WBGene00006397", "Q9GZI6", "WBGene00006387", "Q7YTH5", "WBGene00006390", "G5EF68", "WBGene00006386", "O45784", "WBGene00006391", "Q20361", "WBGene00006395", "P32085", "WBGene00006542", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140" ] }, "reaction_10564498": { "compartment": "compartment_7660", "id": "reaction_10564498", "reactome": "R-CEL-6814885", "name": "CBCAP complex binds 7-methylguanosine cap of snRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10504700", "species_10504346", "species_10564404", "species_10513169" ], "products": [ "species_10564380" ], "modifiers": [], "additional_components": [ "WBGene00017085", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "A5Z2V1", "WBGene00009451", "P34281", "WBGene00015347", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q9N554", "WBGene00021281", "Q22805", "WBGene00020827", "Q9U3K2", "WBGene00008642", "B7WN63", "WBGene00000994", "O01483", "WBGene00015499", "G5EDW9", "WBGene00008361", "H2KML7", "WBGene00013021", "E5QCH1", "WBGene00013877", "Q95ZM2", "WBGene00017608", "W6RQY9", "WBGene00022360", "O18167", "WBGene00012234", "Q17749", "WBGene00015554", "O44500", "WBGene00019822", "Q9U267", "WBGene00013075", "P30641", "WBGene00011143", "species_430042", "G5EG49", "WBGene00013998", "G5EG47", "WBGene00010054", "O44625", "WBGene00004136", "Q9NEX2", "WBGene00013736", "Q9TVL3", "WBGene00000410", "P34424", "WBGene00000508", "P34425", "WBGene00000507", "O17869", "WBGene00009650", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "O16991", "WBGene00006648", "Q9XW26", "WBGene00012735", "P91868", "WBGene00001568", "Q17694", "WBGene00015513", "G5EFV5", "WBGene00000408", "Q17957", "WBGene00006397", "Q9GZI6", "WBGene00006387", "Q7YTH5", "WBGene00006390", "G5EF68", "WBGene00006386", "O45784", "WBGene00006391", "Q20361", "WBGene00006395", "P32085", "WBGene00006542", "WBGene00022192", "A5Z2V1", "WBGene00009451", "P34281", "WBGene00015347", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q9N554", "WBGene00021281", "Q22805", "WBGene00020827", "Q9U3K2", "WBGene00008642", "B7WN63", "WBGene00000994", "O01483", "WBGene00015499", "G5EDW9", "WBGene00008361", "H2KML7", "WBGene00013021", "E5QCH1", "WBGene00013877", "Q95ZM2", "WBGene00017608", "W6RQY9", "WBGene00022360", "O18167", "WBGene00012234", "Q17749", "WBGene00015554", "O44500", "WBGene00019822", "Q9U267", "WBGene00013075", "P30641", "WBGene00011143", "Q9N4E8", "WBGene00022192", "species_430042", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "Q966L5", "WBGene00017085", "G5EG49", "WBGene00013998", "G5EG47", "WBGene00010054", "O44625", "WBGene00004136", "Q9NEX2", "WBGene00013736", "Q9TVL3", "WBGene00000410", "P34424", "WBGene00000508", "P34425", "WBGene00000507", "O17869", "WBGene00009650", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "O16991", "WBGene00006648", "Q9XW26", "WBGene00012735", "P91868", "WBGene00001568", "Q17694", "WBGene00015513", "G5EFV5", "WBGene00000408", "Q17957", "WBGene00006397", "Q9GZI6", "WBGene00006387", "Q7YTH5", "WBGene00006390", "G5EF68", "WBGene00006386", "O45784", "WBGene00006391", "Q20361", "WBGene00006395", "P32085", "WBGene00006542" ] }, "reaction_10564407": { "compartment": "compartment_7660", "id": "reaction_10564407", "reactome": "R-CEL-6814559", "name": "Pre-snRNA is elongated and capped with 7-methylguanosine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29470", "species_29358", "species_113562", "species_10564402", "species_113571" ], "products": [ "species_10564404" ], "modifiers": [ [ "species_10564402", "catalyst" ], [ "species_10564402", "catalyst" ] ], "additional_components": [ "A5Z2V1", "WBGene00009451", "P34281", "WBGene00015347", "Q9N554", "WBGene00021281", "Q22805", "WBGene00020827", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "P16356", "WBGene00000123", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q9U3K2", "WBGene00008642", "B7WN63", "WBGene00000994", "O01483", "WBGene00015499", "G5EDW9", "WBGene00008361", "H2KML7", "WBGene00013021", "E5QCH1", "WBGene00013877", "Q95ZM2", "WBGene00017608", "W6RQY9", "WBGene00022360", 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"WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q9U3K2", "WBGene00008642", "B7WN63", "WBGene00000994", "O01483", "WBGene00015499", "G5EDW9", "WBGene00008361", "H2KML7", "WBGene00013021", "E5QCH1", "WBGene00013877", "Q95ZM2", "WBGene00017608", "W6RQY9", "WBGene00022360", "O18167", "WBGene00012234", "Q17749", "WBGene00015554", "O44500", "WBGene00019822", "Q9U267", "WBGene00013075", "P30641", "WBGene00011143", "G5EG49", "WBGene00013998", "G5EG47", "WBGene00010054", "O44625", "WBGene00004136", "Q9NEX2", "WBGene00013736", "Q9TVL3", "WBGene00000410", "P34424", "WBGene00000508", "P34425", "WBGene00000507", "O17869", "WBGene00009650", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "O16991", "WBGene00006648", "Q9XW26", "WBGene00012735", "P91868", "WBGene00001568", "Q17694", "WBGene00015513", "G5EFV5", "WBGene00000408", "Q17957", "WBGene00006397", "Q9GZI6", "WBGene00006387", "Q7YTH5", "WBGene00006390", "G5EF68", "WBGene00006386", "O45784", "WBGene00006391", "Q20361", "WBGene00006395", "P32085", "WBGene00006542" ] }, "reaction_10563753": { "compartment": "compartment_7660", "id": "reaction_10563753", "reactome": "R-CEL-6810233", "name": "CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10563741" ], "products": [ "species_113582", "species_10563750" ], "modifiers": [ [ "species_10563741", "catalyst" ] ], "additional_components": [ "Q9XW26", "WBGene00012735", "P91868", "WBGene00001568", "Q17694", "WBGene00015513", "G5EG49", "WBGene00013998", "G5EG47", "WBGene00010054", "Q9TVL3", "WBGene00000410", "P34424", "WBGene00000508", "P34425", "WBGene00000507", "O17869", "WBGene00009650", "O44625", "WBGene00004136", "Q9NEX2", "WBGene00013736", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "O16991", "WBGene00006648", "G5EFV5", "WBGene00000408", "Q17957", "WBGene00006397", "Q9GZI6", "WBGene00006387", "Q7YTH5", "WBGene00006390", "G5EF68", "WBGene00006386", "O45784", "WBGene00006391", "Q20361", "WBGene00006395", "P32085", "WBGene00006542", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "P16356", "WBGene00000123", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "G5EG49", "WBGene00013998", "G5EG47", "WBGene00010054", "O44625", "WBGene00004136", "Q9NEX2", "WBGene00013736", "Q9TVL3", "WBGene00000410", "P34424", "WBGene00000508", "P34425", "WBGene00000507", "O17869", "WBGene00009650", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "O16991", "WBGene00006648", "Q9XW26", "WBGene00012735", "P91868", "WBGene00001568", "Q17694", "WBGene00015513", "G5EFV5", "WBGene00000408", "Q17957", "WBGene00006397", "Q9GZI6", "WBGene00006387", "Q7YTH5", "WBGene00006390", "G5EF68", "WBGene00006386", "O45784", "WBGene00006391", "Q20361", "WBGene00006395", "P32085", "WBGene00006542", "Q9XW26", "WBGene00012735", "P91868", "WBGene00001568", "Q17694", "WBGene00015513", "G5EG49", "WBGene00013998", "G5EG47", "WBGene00010054", "Q9TVL3", "WBGene00000410", "P34424", "WBGene00000508", "P34425", "WBGene00000507", "O17869", "WBGene00009650", "O44625", "WBGene00004136", "Q9NEX2", "WBGene00013736", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "O16991", "WBGene00006648", "G5EFV5", "WBGene00000408", "Q17957", "WBGene00006397", "Q9GZI6", "WBGene00006387", "Q7YTH5", "WBGene00006390", "G5EF68", "WBGene00006386", "O45784", "WBGene00006391", "Q20361", "WBGene00006395", "P32085", "WBGene00006542", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140" ] }, "reaction_10564396": { "compartment": "compartment_7660", "id": "reaction_10564396", "reactome": "R-CEL-6814555", "name": "Integrator complex processes the 3' end of snRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10564380" ], "products": [ "species_10564382", "species_10564388" ], "modifiers": [ [ "species_10564380", "catalyst" ], [ "species_10505223", "catalyst" ], [ "species_10564394", "catalyst" ] ], "additional_components": [ "A5Z2V1", "WBGene00009451", "P34281", "WBGene00015347", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q9N554", "WBGene00021281", "Q22805", "WBGene00020827", "Q9U3K2", "WBGene00008642", "B7WN63", "WBGene00000994", "O01483", "WBGene00015499", "G5EDW9", "WBGene00008361", "H2KML7", "WBGene00013021", "E5QCH1", "WBGene00013877", "Q95ZM2", "WBGene00017608", "W6RQY9", "WBGene00022360", "O18167", "WBGene00012234", "Q17749", "WBGene00015554", "O44500", "WBGene00019822", "Q9U267", "WBGene00013075", "P30641", "WBGene00011143", "Q9N4E8", "WBGene00022192", "species_430042", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "Q966L5", "WBGene00017085", "G5EG49", "WBGene00013998", "G5EG47", "WBGene00010054", "O44625", "WBGene00004136", "Q9NEX2", "WBGene00013736", "Q9TVL3", "WBGene00000410", "P34424", "WBGene00000508", "P34425", "WBGene00000507", "O17869", "WBGene00009650", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "O16991", "WBGene00006648", "Q9XW26", "WBGene00012735", "P91868", "WBGene00001568", "Q17694", "WBGene00015513", "G5EFV5", "WBGene00000408", "Q17957", "WBGene00006397", "Q9GZI6", "WBGene00006387", "Q7YTH5", "WBGene00006390", "G5EF68", "WBGene00006386", "O45784", "WBGene00006391", "Q20361", "WBGene00006395", "P32085", "WBGene00006542", "A5Z2V1", "WBGene00009451", "P34281", "WBGene00015347", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", 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"H2KML7", "WBGene00013021", "E5QCH1", "WBGene00013877", "Q95ZM2", "WBGene00017608", "W6RQY9", "WBGene00022360", "O18167", "WBGene00012234", "Q17749", "WBGene00015554", "O44500", "WBGene00019822", "Q9U267", "WBGene00013075", "P30641", "WBGene00011143", "Q9N4E8", "WBGene00022192", "species_430042", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "Q966L5", "WBGene00017085", "G5EG49", "WBGene00013998", "G5EG47", "WBGene00010054", "O44625", "WBGene00004136", "Q9NEX2", "WBGene00013736", "Q9TVL3", "WBGene00000410", "P34424", "WBGene00000508", "P34425", "WBGene00000507", "O17869", "WBGene00009650", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "O16991", "WBGene00006648", "Q9XW26", "WBGene00012735", "P91868", "WBGene00001568", "Q17694", "WBGene00015513", "G5EFV5", "WBGene00000408", "Q17957", "WBGene00006397", "Q9GZI6", "WBGene00006387", "Q7YTH5", "WBGene00006390", "G5EF68", "WBGene00006386", "O45784", "WBGene00006391", "Q20361", "WBGene00006395", "P32085", "WBGene00006542", "WBGene00020092", "WBGene00020480" ] }, "reaction_10548576": { "compartment": "compartment_876", "id": "reaction_10548576", "reactome": "R-CEL-3928591", "name": "EPH:EFN tetramers oligomerise", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10548574", "species_10548572" ], "products": [ "species_10548507" ], "modifiers": [], "additional_components": [ "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "O61460", "WBGene00006868", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "O61460", "WBGene00006868", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "O61460", "WBGene00006868" ] }, "reaction_10548786": { "compartment": "compartment_876", "id": "reaction_10548786", "reactome": "R-CEL-3928646", "name": "EPHAs bind EFNAs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10548447", "species_10548442" ], "products": [ "species_10548465" ], "modifiers": [], "additional_components": [ "WBGene00006868", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "O61460", "WBGene00006868" ] }, "reaction_10549059": { "compartment": "compartment_876", "id": "reaction_10549059", "reactome": "R-CEL-4093342", "name": "SDC2 multimerises", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10549032" ], "products": [ "species_10549057" ], "modifiers": [], "additional_components": [ "WBGene00004749", "P50605", "WBGene00004749" ] }, "reaction_10548585": { "compartment": "compartment_70101", "id": "reaction_10548585", "reactome": "R-CEL-3928592", "name": "p190RhoGEF exchanges GTP for GDP on RHOA, activating it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509486", "species_29438" ], "products": [ "species_29420", "species_10509488" ], "modifiers": [ [ "species_10548582", "catalyst" ] ], "additional_components": [ "Q22038", "WBGene00004357", "species_29420", "Q22038", "WBGene00004357", "species_29438", "A0A0K3AQN0", "WBGene00013682", "O61460", "WBGene00006868", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "Q95YD4", "WBGene00002213" ] }, "reaction_10548714": { "compartment": "compartment_70101", "id": "reaction_10548714", "reactome": "R-CEL-3928620", "name": "PAK1 autophosphorylates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10548701", "species_113592" ], "products": [ "species_29370", "species_10548711" ], "modifiers": [ [ "species_10548701", "catalyst" ] ], "additional_components": [ "Q03206", "ced-10", "species_29438", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "Q03206", "ced-10", "species_29438", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "Q03206", "ced-10", "species_29438", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911" ] }, "reaction_10549035": { "compartment": "compartment_876", "id": "reaction_10549035", "reactome": "R-CEL-4093332", "name": "p-EPHB phosphorylates SDC2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10537380" ], "products": [ "species_29370", "species_10549032" ], "modifiers": [ [ "species_10548561", "catalyst" ] ], "additional_components": [ "WBGene00004749", "WBGene00004749", "O61460", "WBGene00006868", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869" ] }, "reaction_10549038": { "compartment": "compartment_876", "id": "reaction_10549038", "reactome": "R-CEL-4093336", "name": "p-TIAM1 exchanges GTP for GDP on RAC1, activating it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10520575", "species_29438" ], "products": [ "species_29420", "species_10509457" ], "modifiers": [ [ "species_10548757", "catalyst" ] ], "additional_components": [ "species_29420", "Q03206", "ced-10", "species_29438", "Q03206", "ced-10", "O01847", "WBGene00015704", "O61460", "WBGene00006868", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "Q9N3S5", "WBGene00021635", "G5EE56", "WBGene00005077", "G5EGQ9", "WBGene00003774", "species_159549", "G5EEH3", "WBGene00003775", "species_113552" ] }, "reaction_10548784": { "compartment": "compartment_70101", "id": "reaction_10548784", "reactome": "R-CEL-3928645", "name": "EPHB:NMDAR binds TIAM1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10548750", "species_10516084" ], "products": [ "species_10548752" ], "modifiers": [], "additional_components": [ "O61460", "WBGene00006868", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "Q9N3S5", "WBGene00021635", "G5EE56", "WBGene00005077", "G5EGQ9", "WBGene00003774", "species_159549", "G5EEH3", "WBGene00003775", "species_113552", "WBGene00015704", "O01847", "WBGene00015704", "O61460", "WBGene00006868", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "Q9N3S5", "WBGene00021635", "G5EE56", "WBGene00005077", "G5EGQ9", "WBGene00003774", "species_159549", "G5EEH3", "WBGene00003775", "species_113552" ] }, "reaction_10548599": { "compartment": "compartment_876", "id": "reaction_10548599", "reactome": "R-CEL-3928595", "name": "N-WASP binds ARP2/3 and G-actin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10537823", "species_10515381", "species_10548595" ], "products": [ "species_10548597" ], "modifiers": [], "additional_components": [ "P58798", "WBGene00000204", "A0A3P6PCS5", "WBGene00000201", "Q9N4I0", "WBGene00000199", "species_29358", "Q8WTM6", "WBGene00021170", "P53489", "WBGene00000200", "Q9XWV3", "WBGene00000203", "O61861", "WBGene00000205", "P91167", "WBGene00016729", "P0DM41", "WBGene00000063", "P0DM42", "WBGene00000065", "P10984", "WBGene00000064", "P10986", "WBGene00000066", "species_29358", "Q05062", "WBGene00000390", "species_29438", "O61460", "WBGene00006868", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "A0A0K3AS36", "Y116A8C.36d", "species_179856", "Q05062", "WBGene00000390", "species_29438", "O61460", "WBGene00006868", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "A0A0K3AS36", "Y116A8C.36d", "species_179856", "P0DM41", "WBGene00000063", "P0DM42", "WBGene00000065", "P10984", "WBGene00000064", "P10986", "WBGene00000066", "species_29358", "P58798", "WBGene00000204", "A0A3P6PCS5", "WBGene00000201", "Q9N4I0", "WBGene00000199", "Q8WTM6", "WBGene00021170", "P53489", "WBGene00000200", "Q9XWV3", "WBGene00000203", "O61861", "WBGene00000205", "P91167", "WBGene00016729" ] }, "reaction_10548760": { "compartment": "compartment_70101", "id": "reaction_10548760", "reactome": "R-CEL-3928627", "name": "EPHB phosphorylates TIAM1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10548752" ], "products": [ "species_29370", "species_10548757" ], "modifiers": [ [ "species_10548752", "catalyst" ] ], "additional_components": [ "O01847", "WBGene00015704", "O61460", "WBGene00006868", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "Q9N3S5", "WBGene00021635", "G5EE56", "WBGene00005077", "G5EGQ9", "WBGene00003774", "species_159549", "G5EEH3", "WBGene00003775", "species_113552", "O01847", "WBGene00015704", "O61460", "WBGene00006868", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "Q9N3S5", "WBGene00021635", "G5EE56", "WBGene00005077", "G5EGQ9", "WBGene00003774", "species_159549", "G5EEH3", "WBGene00003775", "species_113552", "O01847", "WBGene00015704", "O61460", "WBGene00006868", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "Q9N3S5", "WBGene00021635", "G5EE56", "WBGene00005077", "G5EGQ9", "WBGene00003774", "species_159549", "G5EEH3", "WBGene00003775", "species_113552" ] }, "reaction_10548378": { "compartment": "compartment_876", "id": "reaction_10548378", "reactome": "R-CEL-3928576", "name": "RHOA:GTP binds ROCK, activating it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10521949", "species_10509488" ], "products": [ "species_10521951" ], "modifiers": [], "additional_components": [ "P92199", "WBGene00002694", "Q21025", "WBGene00019087", "Q9XVH4", "WBGene00019087", "Q22038", "WBGene00004357", "species_29438", "Q22038", "WBGene00004357", "species_29438", "P92199", "WBGene00002694", "Q21025", "WBGene00019087", "Q9XVH4", "WBGene00019087" ] }, "reaction_10548603": { "compartment": "compartment_70101", "id": "reaction_10548603", "reactome": "R-CEL-3928598", "name": "Recruitment of p190RhoGEF to p-FAK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10548580", "species_10548578" ], "products": [ "species_10548582" ], "modifiers": [], "additional_components": [ "O61460", "WBGene00006868", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "Q95YD4", "WBGene00002213", "WBGene00013682", "A0A0K3AQN0", "WBGene00013682", "O61460", "WBGene00006868", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "Q95YD4", "WBGene00002213" ] }, "reaction_10548605": { "compartment": "compartment_876", "id": "reaction_10548605", "reactome": "R-CEL-3928601", "name": "CDC42 and PIP2 bind WASL, activating it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179856", "species_10548593" ], "products": [ "species_10548595" ], "modifiers": [], "additional_components": [ "Q05062", "WBGene00000390", "species_29438", "O61460", "WBGene00006868", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "A0A0K3AS36", "Y116A8C.36d", "Q05062", "WBGene00000390", "species_29438", "O61460", "WBGene00006868", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "A0A0K3AS36", "Y116A8C.36d", "species_179856" ] }, "reaction_10548703": { "compartment": "compartment_876", "id": "reaction_10548703", "reactome": "R-CEL-3928619", "name": "PAK1 binds RAC1:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10516065", "species_10520672" ], "products": [ "species_10548701" ], "modifiers": [], "additional_components": [ "Q03206", "ced-10", "species_29438", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "Q03206", "ced-10", "species_29438", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911" ] }, "reaction_10549055": { "compartment": "compartment_876", "id": "reaction_10549055", "reactome": "R-CEL-4093339", "name": "p120-RasGAP activates GTP hydrolysis on RAS, inactivating it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10549048" ], "products": [ "species_29372", "species_10549052" ], "modifiers": [ [ "species_10549048", "catalyst" ] ], "additional_components": [ "O61460", "WBGene00006868", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "P22981", "WBGene00002335", "species_29438", "O61460", "WBGene00006868", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "P22981", "WBGene00002335", "species_29420", "O61460", "WBGene00006868", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "P22981", "WBGene00002335", "species_29438" ] }, "reaction_10548566": { "compartment": "compartment_70101", "id": "reaction_10548566", "reactome": "R-CEL-3928578", "name": "EPH receptors autophosphorylate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10548507", "species_113592" ], "products": [ "species_29370", "species_10548563" ], "modifiers": [ [ "species_10548507", "catalyst" ] ], "additional_components": [ "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "O61460", "WBGene00006868", "O61460", "WBGene00006868", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "O61460", "WBGene00006868" ] }, "reaction_10548601": { "compartment": "compartment_876", "id": "reaction_10548601", "reactome": "R-CEL-3928597", "name": "EPH:EFN dimers tetramerise", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10548574" ], "products": [ "species_10548572" ], "modifiers": [], "additional_components": [ "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "O61460", "WBGene00006868", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "O61460", "WBGene00006868" ] }, "reaction_10548768": { "compartment": "compartment_876", "id": "reaction_10548768", "reactome": "R-CEL-3928633", "name": "bPIX exchanges GTP for GDP on RAC, activating it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10516063", "species_29438", "species_10548718" ], "products": [ "species_114549", "species_10548720" ], "modifiers": [ [ "species_10548718", "catalyst" ] ], "additional_components": [ "species_29420", "Q03206", "ced-10", "Q21430", "WBGene00010776", "O61460", "WBGene00006868", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q95PX0", "WBGene00006410", "Q19467", "WBGene00008805", "Q03206", "ced-10", "species_29438", "Q21430", "WBGene00010776", "O61460", "WBGene00006868", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q95PX0", "WBGene00006410", "Q19467", "WBGene00008805", "Q21430", "WBGene00010776", "O61460", "WBGene00006868", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q95PX0", "WBGene00006410", "Q19467", "WBGene00008805" ] }, "reaction_10548770": { "compartment": "compartment_70101", "id": "reaction_10548770", "reactome": "R-CEL-3928639", "name": "p-EFNB binds GRB4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10518535", "species_10548675" ], "products": [ "species_10548677" ], "modifiers": [], "additional_components": [ "WBGene00006410", "O61460", "WBGene00006868", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "O61460", "WBGene00006868", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q95PX0", "WBGene00006410" ] }, "reaction_10548691": { "compartment": "compartment_70101", "id": "reaction_10548691", "reactome": "R-CEL-3928615", "name": "EFNBs bind SFKs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10548620", "species_10548503" ], "products": [ "species_10548689" ], "modifiers": [], "additional_components": [ "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "O61460", "WBGene00006868", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "O61460", "WBGene00006868", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635" ] }, "reaction_10548739": { "compartment": "compartment_70101", "id": "reaction_10548739", "reactome": "R-CEL-3928625", "name": "PAKs autophosphorylate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10548724" ], "products": [ "species_29370", "species_10548736" ], "modifiers": [ [ "species_10548724", "catalyst" ] ], "additional_components": [ "Q03206", "ced-10", "species_29438", "Q21430", "WBGene00010776", "O61460", "WBGene00006868", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q95PX0", "WBGene00006410", "Q19467", "WBGene00008805", "Q17850", "WBGene00003911", "G5EGQ3", "WBGene00003144", "Q03206", "ced-10", "species_29438", "Q21430", "WBGene00010776", "O61460", "WBGene00006868", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q95PX0", "WBGene00006410", "Q19467", "WBGene00008805", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "Q03206", "ced-10", "species_29438", "Q21430", "WBGene00010776", "O61460", "WBGene00006868", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q95PX0", "WBGene00006410", "Q19467", "WBGene00008805", "Q17850", "WBGene00003911", "G5EGQ3", "WBGene00003144" ] }, "reaction_10548773": { "compartment": "compartment_70101", "id": "reaction_10548773", "reactome": "R-CEL-3928640", "name": "PAKs phosphorylate MLC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10525019", "species_113592" ], "products": [ "species_29370", "species_10524835" ], "modifiers": [ [ "species_10548736", "catalyst" ] ], "additional_components": [ "WBGene00003372", "WBGene00003372", "Q03206", "ced-10", "species_29438", "Q21430", "WBGene00010776", "O61460", "WBGene00006868", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q95PX0", "WBGene00006410", "Q19467", "WBGene00008805", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911" ] }, "reaction_10548775": { "compartment": "compartment_70101", "id": "reaction_10548775", "reactome": "R-CEL-3928641", "name": "PAK binds RAC and bPIX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10548722", "species_10548720" ], "products": [ "species_10548724" ], "modifiers": [], "additional_components": [ "Q17850", "WBGene00003911", "G5EGQ3", "WBGene00003144", "Q03206", "ced-10", "species_29438", "Q21430", "WBGene00010776", "O61460", "WBGene00006868", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q95PX0", "WBGene00006410", "Q19467", "WBGene00008805", "Q03206", "ced-10", "species_29438", "Q21430", "WBGene00010776", "O61460", "WBGene00006868", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q95PX0", "WBGene00006410", "Q19467", "WBGene00008805", "Q17850", "WBGene00003911", "G5EGQ3", "WBGene00003144" ] }, "reaction_10548765": { "compartment": "compartment_70101", "id": "reaction_10548765", "reactome": "R-CEL-3928631", "name": "GIT1 binds bPIX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10548685", "species_10512284" ], "products": [ "species_10548718" ], "modifiers": [], "additional_components": [ "O61460", "WBGene00006868", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q95PX0", "WBGene00006410", "Q19467", "WBGene00008805", "WBGene00010776", "Q21430", "WBGene00010776", "O61460", "WBGene00006868", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q95PX0", "WBGene00006410", "Q19467", "WBGene00008805" ] }, "reaction_10548687": { "compartment": "compartment_70101", "id": "reaction_10548687", "reactome": "R-CEL-3928614", "name": "EFNB:GRB4 binds GIT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10548683", "species_10548677" ], "products": [ "species_10548685" ], "modifiers": [], "additional_components": [ "WBGene00008805", "O61460", "WBGene00006868", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q95PX0", "WBGene00006410", "O61460", "WBGene00006868", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q95PX0", "WBGene00006410", "Q19467", "WBGene00008805" ] }, "reaction_10548716": { "compartment": "compartment_876", "id": "reaction_10548716", "reactome": "R-CEL-3928624", "name": "EPHBs bind EFNBs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10548493", "species_10548491" ], "products": [ "species_10548503" ], "modifiers": [], "additional_components": [ "WBGene00006868", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "O61460", "WBGene00006868" ] }, "reaction_10548796": { "compartment": "compartment_876", "id": "reaction_10548796", "reactome": "R-CEL-3928651", "name": "NGEF exchanges GTP for GDP on RHOA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10509486" ], "products": [ "species_29420", "species_10509488" ], "modifiers": [ [ "species_10548793", "catalyst" ] ], "additional_components": [ "Q22038", "WBGene00004357", "species_29420", "Q22038", "WBGene00004357", "species_29438", "Q965J0", "WBGene00019487", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "O61460", "WBGene00006868", "Q9N3S5", "WBGene00021635", "G5EE56", "WBGene00005077" ] }, "reaction_10573063": { "compartment": "compartment_7660", "id": "reaction_10573063", "reactome": "R-CEL-9671145", "name": "DKC1 binds SHQ1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10510127", "species_10573059" ], "products": [ "species_10573061" ], "modifiers": [], "additional_components": [ "WBGene00010478", "WBGene00021655", "Q9TYM6", "WBGene00021655", "O17919", "WBGene00010478" ] }, "reaction_10528993": { "compartment": "compartment_17963", "id": "reaction_10528993", "reactome": "R-CEL-914012", "name": "GCNTs transfer GlcNAc from UDP-GlcNAc to Core 1 mucins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_914003", "species_10528918" ], "products": [ "species_10528926", "species_205687" ], "modifiers": [ [ "species_10528990", "catalyst" ] ], "additional_components": [ "Q9U2D6", "WBGene00012901", "P34501", "WBGene00010540", "Q9U2D6", "WBGene00012901", "P34501", "WBGene00010540", "G5EEZ8", "WBGene00001640", "G5EBK7", "WBGene00001644", "O02315", "WBGene00001642", "G5ECK8", "WBGene00001626", "Q19730", "WBGene00001643", "G5EDP7", "WBGene00001641" ] }, "reaction_10528675": { "compartment": "compartment_17963", "id": "reaction_10528675", "reactome": "R-CEL-914006", "name": "Addition of galactose to the Tn antigen via an alpha-1,3 linkage forms a Core 8 glycoprotein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10528570", "species_735682" ], "products": [ "species_205687", "species_10528673" ], "modifiers": [], "additional_components": [ "Q9U2D6", "WBGene00012901", "P34501", "WBGene00010540", "Q9U2D6", "WBGene00012901", "P34501", "WBGene00010540" ] }, "reaction_10529014": { "compartment": "compartment_20699", "id": "reaction_10529014", "reactome": "R-CEL-914018", "name": "Addition of GlcNAc to Core 3 forms a Core 4 glycoprotein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_914003", "species_10528693" ], "products": [ "species_205687", "species_10529011" ], "modifiers": [ [ "species_10528960", "catalyst" ] ], "additional_components": [ "Q9U2D6", "WBGene00012901", "P34501", "WBGene00010540", "P34501", "WBGene00010540", "Q9U2D6", "WBGene00012901", "WBGene00001640" ] }, "reaction_10538297": { "compartment": "compartment_20699", "id": "reaction_10538297", "reactome": "R-CEL-1964505", "name": "C1GALT1 transfers Galactose to the Tn antigen forming Core 1 glycoproteins (T antigens)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10528570", "species_735682" ], "products": [ "species_10528918", "species_205687" ], "modifiers": [ [ "species_10538294", "catalyst" ] ], "additional_components": [ "Q9U2D6", "WBGene00012901", "P34501", "WBGene00010540", "Q9U2D6", "WBGene00012901", "P34501", "WBGene00010540", "Q18515", "WBGene00021403", "O44563", "WBGene00044620", "O17053", "WBGene00021403", "Q22900", "WBGene00021403", "O45579", "WBGene00021403", "O17747", "WBGene00021403", "G5ECT3", "WBGene00021403", "P41881", "WBGene00021403", "O18184", "WBGene00021403", "O16535", "WBGene00021403" ] }, "reaction_10528665": { "compartment": "compartment_17963", "id": "reaction_10528665", "reactome": "R-CEL-914005", "name": "Addition of GlcNAc to the Tn antigen via an alpha-1,3 linkage forms a Core 5 glycoprotein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_914003", "species_10528570" ], "products": [ "species_10528663", "species_205687" ], "modifiers": [], "additional_components": [ "Q9U2D6", "WBGene00012901", "P34501", "WBGene00010540", "Q9U2D6", "WBGene00012901", "P34501", "WBGene00010540" ] }, "reaction_10529003": { "compartment": "compartment_17963", "id": "reaction_10529003", "reactome": "R-CEL-914017", "name": "Addition of GalNAc to the Tn antigen via an alpha-1,6 linkage forms a Core 7 glycoprotein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_735700", "species_10528570" ], "products": [ "species_10529001", "species_205687" ], "modifiers": [], "additional_components": [ "Q9U2D6", "WBGene00012901", "P34501", "WBGene00010540", "Q9U2D6", "WBGene00012901", "P34501", "WBGene00010540" ] }, "reaction_10528685": { "compartment": "compartment_17963", "id": "reaction_10528685", "reactome": "R-CEL-914008", "name": "Addition of GlcNAc to the Tn antigen via a beta-1,6 linkage forms a Core 6 glycoprotein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_914003", "species_10528570" ], "products": [ "species_10528683", "species_205687" ], "modifiers": [], "additional_components": [ "Q9U2D6", "WBGene00012901", "P34501", "WBGene00010540", "Q9U2D6", "WBGene00012901", "P34501", "WBGene00010540" ] }, "reaction_10528910": { "compartment": "compartment_20699", "id": "reaction_10528910", "reactome": "R-CEL-914010", "name": "Addition of GlcNAc to the Tn antigen forms a Core 3 glycoprotein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_914003", "species_10528570" ], "products": [ "species_10528693", "species_205687" ], "modifiers": [ [ "species_10528907", "catalyst" ] ], "additional_components": [ "Q9U2D6", "WBGene00012901", "P34501", "WBGene00010540", "Q9U2D6", "WBGene00012901", "P34501", "WBGene00010540", "Q9XU74", "WBGene00011780", "O62163", "WBGene00011780", "H2L0F4", "WBGene00044618", "O62165", "WBGene00011780", "O02231", "WBGene00011780", "O62375", "WBGene00011780", "O02310", "WBGene00011780", "Q20575", "WBGene00011780", "O17750", "WBGene00011780", "Q6QMT2", "WBGene00000267", "O62114", "WBGene00011780", "G5ECA6", "WBGene00011780", "Q8MQG4", "WBGene00011780", "O62115", "WBGene00011780", "G5EDB3", "WBGene00044630" ] }, "reaction_10528639": { "compartment": "compartment_20699", "id": "reaction_10528639", "reactome": "R-CEL-913675", "name": "GALNTs transfer GalNAc from UDP-GalNAc to mucins to form Tn antigens", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_735700", "species_10528562" ], "products": [ "species_10528570", "species_205687" ], "modifiers": [ [ "species_10528636", "catalyst" ] ], "additional_components": [ "P34501", "WBGene00010540", "Q9U2D6", "WBGene00012901", "Q9U2D6", "WBGene00012901", "P34501", "WBGene00010540", "O61397", "WBGene00001632", "Q95ZJ1", "WBGene00001630", "O61394", "WBGene00001631", "P34678", "WBGene00001628", "Q7K755", "WBGene00001636", "Q8I136", "WBGene00001629", "Q9U2C4", "WBGene00012934" ] }, "reaction_10550347": { "compartment": "compartment_12045", "id": "reaction_10550347", "reactome": "R-CEL-5173192", "name": "POFUT2 transfers fucose to TSR domain-containing proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10550339" ], "products": [ "species_10550147" ], "modifiers": [ [ "species_10550344", "catalyst" ] ], "additional_components": [ "Q19305", "WBGene00006893", "Q966Q0", "WBGene00017376", "Q19349", "WBGene00017376", "G5ECS8", "WBGene00000082", "Q19791", "WBGene00001650", "O76840", "WBGene00003242", "G5ECS8", "WBGene00000082", "Q19791", "WBGene00001650", "Q19349", "WBGene00017376", "Q966Q0", "WBGene00017376", "Q19305", "WBGene00006893", "O76840", "WBGene00003242", "WBGene00010757" ] }, "reaction_10550251": { "compartment": "compartment_12045", "id": "reaction_10550251", "reactome": "R-CEL-5173005", "name": "B3GALTL transfers glucose to O-fucosyl-proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_173594", "species_10550147" ], "products": [ "species_158602", "species_10550243" ], "modifiers": [ [ "species_10550248", "catalyst" ] ], "additional_components": [ "G5ECS8", "WBGene00000082", "Q19791", "WBGene00001650", "Q19349", "WBGene00017376", "Q966Q0", "WBGene00017376", "Q19305", "WBGene00006893", "O76840", "WBGene00003242", "Q19349", "WBGene00017376", "Q966Q0", "WBGene00017376", "G5ECS8", "WBGene00000082", "Q19791", "WBGene00001650", "Q19305", "WBGene00006893", "O76840", "WBGene00003242", "WBGene00022576" ] }, "reaction_10532278": { "compartment": "compartment_70101", "id": "reaction_10532278", "reactome": "R-CEL-1236970", "name": "Proteasomal clevage of exogenous antigen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1236719" ], "products": [ "species_8942986", "species_983036" ], "modifiers": [ [ "species_10502572", "catalyst" ] ], "additional_components": [ "P91477", "WBGene00003950", "Q95PZ7", "WBGene00013435", "Q18115", "WBGene00004459", "O62102", "WBGene00003948", "O17071", "WBGene00004504", "Q10920", "WBGene00016623", "P34286", "WBGene00003952", "Q9XTT9", "WBGene00004506", "Q23449", "WBGene00004468", "Q95005", "WBGene00003925", "P46502", "WBGene00004503", "O61792", "WBGene00004464", "O17586", "WBGene00003922", "O76371", "WBGene00004505", "Q20585", "WBGene00004463", "Q95008", "WBGene00003926", "Q18787", "WBGene00004501", "Q20058", "WBGene00009445", "Q9N599", "WBGene00003924", "O16368", "WBGene00004502", "O61742", "WBGene00004466", "Q09583", "WBGene00003928", "Q966I8", "WBGene00003947", "Q04908", "WBGene00004460", "Q9XUV0", "WBGene00003951", "Q27488", "WBGene00003923", "Q9GZH5", "WBGene00004458", "O44156", "WBGene00003927", "Q22253", "WBGene00004465", "O76577", "WBGene00004467", "P90868", "WBGene00003953", "Q19324", "WBGene00004461", "Q17971", "WBGene00007588", "Q23237", "WBGene00003949", "Q20938", "WBGene00004462" ] }, "reaction_10534835": { "compartment": "compartment_12045", "id": "reaction_10534835", "reactome": "R-CEL-1482647", "name": "2-MAG and DAG are transacylated to TAG by PNPLA2/3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1498728", "species_1500596" ], "products": [ "species_76116", "species_1500594" ], "modifiers": [ [ "species_10534832", "catalyst" ] ], "additional_components": [ "Q11186", "WBGene00015484", "Q18948", "WBGene00015241", "Q9N5Z7", "WBGene00015241" ] }, "reaction_10534837": { "compartment": "compartment_12045", "id": "reaction_10534837", "reactome": "R-CEL-1482654", "name": "2-MAG is transacylated to DAG by PNPLA2/3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1498728" ], "products": [ "species_76116", "species_1500596" ], "modifiers": [ [ "species_10534832", "catalyst" ] ], "additional_components": [ "Q11186", "WBGene00015484", "Q18948", "WBGene00015241", "Q9N5Z7", "WBGene00015241" ] }, "reaction_10534887": { "compartment": "compartment_12045", "id": "reaction_10534887", "reactome": "R-CEL-1482811", "name": "DAG is hydrolyzed to 2-MAG by PNPLA2/3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1500596" ], "products": [ "species_1498728", "species_1524021" ], "modifiers": [ [ "species_10534832", "catalyst" ] ], "additional_components": [ "Q11186", "WBGene00015484", "Q18948", "WBGene00015241", "Q9N5Z7", "WBGene00015241" ] }, "reaction_10534873": { "compartment": "compartment_12045", "id": "reaction_10534873", "reactome": "R-CEL-1482777", "name": "TAG is hydrolyzed to DAG by PNPLA2/3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1500594" ], "products": [ "species_1524021", "species_1500596" ], "modifiers": [ [ "species_10534832", "catalyst" ] ], "additional_components": [ "Q11186", "WBGene00015484", "Q18948", "WBGene00015241", "Q9N5Z7", "WBGene00015241" ] }, "reaction_10534923": { "compartment": "compartment_12045", "id": "reaction_10534923", "reactome": "R-CEL-1482889", "name": "DAG is acylated to TAG by DGAT1/2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500578", "species_1500596" ], "products": [ "species_1500594", "species_76194" ], "modifiers": [ [ "species_10534920", "catalyst" ] ], "additional_components": [ "Q9NCE1", "WBGene00010408", "Q9XUW0", "WBGene00010296", "O01881", "WBGene00021818", "Q23067", "WBGene00020910", "Q9N4S3", "WBGene00021818" ] }, "reaction_10557644": { "compartment": "compartment_12045", "id": "reaction_10557644", "reactome": "R-CEL-5696448", "name": "AWAT2 transfers acyl group from acyl-CoA to MAG, forming DAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5696449", "species_6782195" ], "products": [ "species_76194", "species_1500596" ], "modifiers": [ [ "species_10557641", "catalyst" ] ], "additional_components": [ "O01881", "WBGene00021818", "Q23067", "WBGene00020910", "Q9N4S3", "WBGene00021818", "Q9XUW0", "WBGene00010296" ] }, "reaction_10564718": { "compartment": "compartment_12045", "id": "reaction_10564718", "reactome": "R-CEL-8848580", "name": "DGAT2L6,L7P transfer acyl group from acyl-CoA to DAG, forming TAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500578", "species_1500596" ], "products": [ "species_1500594", "species_76194" ], "modifiers": [ [ "species_10564715", "catalyst" ] ], "additional_components": [ "O01881", "WBGene00021818", "Q23067", "WBGene00020910", "Q9N4S3", "WBGene00021818", "Q9XUW0", "WBGene00010296" ] }, "reaction_10517713": { "compartment": "compartment_70101", "id": "reaction_10517713", "reactome": "R-CEL-265295", "name": "Prostaglandin E synthase isomerizes PGH2 to PGE2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_265283" ], "products": [ "species_265287" ], "modifiers": [ [ "species_10517710", "catalyst" ] ], "additional_components": [ "Q21925", "WBGene00011239", "Q23280", "WBGene00022599" ] }, "reaction_10542977": { "compartment": "compartment_70101", "id": "reaction_10542977", "reactome": "R-CEL-2161614", "name": "PGD2 is reduced to 11-epi-PGF2a by AKRIC3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_879629" ], "products": [ "species_29366", "species_2142710" ], "modifiers": [ [ "species_10513233", "catalyst" ] ], "additional_components": [ "P91020", "WBGene00016985", "Q18903", "WBGene00016985", "Q23320", "WBGene00016985" ] }, "reaction_10542982": { "compartment": "compartment_70101", "id": "reaction_10542982", "reactome": "R-CEL-2161701", "name": "PGH2 is isomerised to PGD2 by HPGDS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_265283" ], "products": [ "species_879629" ], "modifiers": [ [ "species_10542979", "catalyst" ] ], "additional_components": [ "Q09607", "WBGene00001784", "species_1655887" ] }, "reaction_10542974": { "compartment": "compartment_70101", "id": "reaction_10542974", "reactome": "R-CEL-2161549", "name": "PGH2 is reduced to PGF2a by AKR1C3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_265283", "species_29364" ], "products": [ "species_29366", "species_879535" ], "modifiers": [ [ "species_10513233", "catalyst" ] ], "additional_components": [ "P91020", "WBGene00016985", "Q18903", "WBGene00016985", "Q23320", "WBGene00016985" ] }, "reaction_10569857": { "compartment": "compartment_70616", "id": "reaction_10569857", "reactome": "R-CEL-8953461", "name": "SMDT1 assists in assembling MCU, MCUB, MICU1, MICU2 (or MICU3) yielding the MCU complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10568878", "species_10568873", "species_10568887", "species_10568868", "species_10568866" ], "products": [ "species_10568889" ], "modifiers": [], "additional_components": [ "WBGene00008980", "WBGene00013462", "Q18874", "WBGene00008345", "WBGene00019296", "WBGene00019296", "Q21121", "WBGene00019296", "Q18874", "WBGene00008345", "Q95PZ2", "WBGene00013462", "Q9U3I4", "WBGene00008980" ] }, "reaction_10568954": { "compartment": "compartment_70616", "id": "reaction_10568954", "reactome": "R-CEL-8949649", "name": "PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10568937" ], "products": [ "species_10568878", "species_10568939", "species_10568933" ], "modifiers": [ [ "species_10568951", "catalyst" ] ], "additional_components": [ "P54813", "WBGene00010842", "Q9N3T5", "WBGene00004978", "species_216785", "Q9BKU4", "WBGene00004014", "P50093", "WBGene00004015", "Q2HQK3", "WBGene00044745", "G5EDB6", "WBGene00021425", "Q9U3I4", "WBGene00008980", "WBGene00008980", "WBGene00008980", "P54813", "WBGene00010842", "Q9N3T5", "WBGene00004978", "species_216785", "Q9BKU4", "WBGene00004014", "P50093", "WBGene00004015", "Q2HQK3", "WBGene00044745", "G5EDB6", "WBGene00021425", "Q95XN2", "WBGene00022159", "Q23295", "WBGene00013880" ] }, "reaction_10568957": { "compartment": "compartment_70616", "id": "reaction_10568957", "reactome": "R-CEL-8949659", "name": "AFG3L2 (m-AAA protease) degrades SMDT1 that is not assembled in MCU", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10568878" ], "products": [], "modifiers": [ [ "species_10568933", "catalyst" ] ], "additional_components": [ "WBGene00008980", "P54813", "WBGene00010842", "Q9N3T5", "WBGene00004978", "species_216785", "Q9BKU4", "WBGene00004014", "P50093", "WBGene00004015", "Q2HQK3", "WBGene00044745", "G5EDB6", "WBGene00021425" ] }, "reaction_10568959": { "compartment": "compartment_70616", "id": "reaction_10568959", "reactome": "R-CEL-8949661", "name": "C2orf47:AFG3L2 binds the transit peptide of SMDT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10568935", "species_10568933" ], "products": [ "species_10568937" ], "modifiers": [], "additional_components": [ "WBGene00008980", "P54813", "WBGene00010842", "Q9N3T5", "WBGene00004978", "species_216785", "Q9BKU4", "WBGene00004014", "P50093", "WBGene00004015", "Q2HQK3", "WBGene00044745", "G5EDB6", "WBGene00021425", "P54813", "WBGene00010842", "Q9N3T5", "WBGene00004978", "species_216785", "Q9BKU4", "WBGene00004014", "P50093", "WBGene00004015", "Q2HQK3", "WBGene00044745", "G5EDB6", "WBGene00021425", "Q9U3I4", "WBGene00008980" ] }, "reaction_10568964": { "compartment": "compartment_70616", "id": "reaction_10568964", "reactome": "R-CEL-8949688", "name": "SLC8B1 (NCLX) exchanges sodium (mitochondrial intermembrane space) for calcium (mitochondrial matrix)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2889072", "species_8949220" ], "products": [ "species_8949232", "species_2889083" ], "modifiers": [ [ "species_10568961", "catalyst" ] ], "additional_components": [ "WBGene00003572" ] }, "reaction_10568892": { "compartment": "compartment_70616", "id": "reaction_10568892", "reactome": "R-CEL-8949178", "name": "MCU translocates calcium from the mitochondrial intermembrane space to the mitochondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8949232" ], "products": [ "species_8949220" ], "modifiers": [ [ "species_10568889", "catalyst" ] ], "additional_components": [ "Q21121", "WBGene00019296", "Q18874", "WBGene00008345", "Q95PZ2", "WBGene00013462", "Q9U3I4", "WBGene00008980" ] }, "reaction_10505728": { "compartment": "compartment_70101", "id": "reaction_10505728", "reactome": "R-CEL-72670", "name": "Formation of eIF2:GDP:eIF2B intermediate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10505724", "species_10505685" ], "products": [ "species_10505726" ], "modifiers": [], "additional_components": [ "G5EFF9", "WBGene00008670", "Q18994", "WBGene00008428", "P34604", "WBGene00014221", "P80361", "WBGene00004090", "Q9XWD5", "WBGene00012950", "species_29420", "Q9BKU3", "WBGene00021351", "Q21230", "WBGene00010560", "Q95XR0", "WBGene00021466", "species_29420", "G5EFF9", "WBGene00008670", "Q18994", "WBGene00008428", "P34604", "WBGene00014221", "P80361", "WBGene00004090", "Q9XWD5", "WBGene00012950", "Q9BKU3", "WBGene00021351", "Q21230", "WBGene00010560", "Q95XR0", "WBGene00021466" ] }, "reaction_10506002": { "compartment": "compartment_70101", "id": "reaction_10506002", "reactome": "R-CEL-72722", "name": "eIF2 activation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10505726" ], "products": [ "species_10505724", "species_29420", "species_10505633" ], "modifiers": [ [ "species_10505724", "catalyst" ] ], "additional_components": [ "species_29420", "G5EFF9", "WBGene00008670", "Q18994", "WBGene00008428", "P34604", "WBGene00014221", "P80361", "WBGene00004090", "Q9XWD5", "WBGene00012950", "Q9BKU3", "WBGene00021351", "Q21230", "WBGene00010560", "Q95XR0", "WBGene00021466", "G5EFF9", "WBGene00008670", "Q18994", "WBGene00008428", "P34604", "WBGene00014221", "P80361", "WBGene00004090", "Q9XWD5", "WBGene00012950", "species_29438", "Q9BKU3", "WBGene00021351", "Q21230", "WBGene00010560", "Q95XR0", "WBGene00021466", "G5EFF9", "WBGene00008670", "Q18994", "WBGene00008428", "P34604", "WBGene00014221", "P80361", "WBGene00004090", "Q9XWD5", "WBGene00012950" ] }, "reaction_10508240": { "compartment": "compartment_5460", "id": "reaction_10508240", "reactome": "R-CEL-77312", "name": "(S)-Hydroxybutanoyl-CoA+NAD<=>Acetoacetyl-CoA+NADH+H", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113526", "species_77251" ], "products": [ "species_73871", "species_113529", "species_29362" ], "modifiers": [ [ "species_10508194", "catalyst" ] ], "additional_components": [ "P41938", "WBGene00007129" ] }, "reaction_10508242": { "compartment": "compartment_5460", "id": "reaction_10508242", "reactome": "R-CEL-77314", "name": "Crotonoyl-CoA+H2O<=>(S)-3-Hydroxybutanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77313", "species_113521" ], "products": [ "species_77251" ], "modifiers": [ [ "species_10503463", "catalyst" ] ], "additional_components": [ "P34559", "WBGene00001155" ] }, "reaction_10552459": { "compartment": "compartment_876", "id": "reaction_10552459", "reactome": "R-CEL-5577234", "name": "KCND tetramer:KCNIP tetramer transport K+ from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10552456", "catalyst" ] ], "additional_components": [ "Q95XD1", "WBGene00022240", "O45313", "WBGene00008307", "A0A4V0IK35", "WBGene00015867", "G5EGM2", "WBGene00008998", "O16638", "WBGene00021116" ] }, "reaction_10571473": { "compartment": "compartment_70101", "id": "reaction_10571473", "reactome": "R-CEL-9018862", "name": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_9022655" ], "products": [ "species_9022660" ], "modifiers": [ [ "species_10517863", "catalyst" ] ], "additional_components": [ "species_216785", "G5EFT4", "WBGene00016589" ] }, "reaction_10571478": { "compartment": "compartment_70101", "id": "reaction_10571478", "reactome": "R-CEL-9018868", "name": "GPX4-2 reduces 18(S)-HpEPE to 18(S)-HEPE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9020583", "species_29450" ], "products": [ "species_29356", "species_9020474", "species_111745" ], "modifiers": [ [ "species_10571475", "catalyst" ] ], "additional_components": [ "WBGene00019846" ] }, "reaction_10521687": { "compartment": "compartment_876", "id": "reaction_10521687", "reactome": "R-CEL-416690", "name": "SEMA4A binds to PLXND1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10521671", "species_10521683" ], "products": [ "species_10521685" ], "modifiers": [], "additional_components": [ "O45657", "WBGene00004048", "U4PRY7", "WBGene00004047", "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "Q95XP4", "WBGene00003111", "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "Q95XP4", "WBGene00003111", "O45657", "WBGene00004048", "U4PRY7", "WBGene00004047" ] }, "reaction_10521675": { "compartment": "compartment_984", "id": "reaction_10521675", "reactome": "R-CEL-416683", "name": "SEMA3E binds to PLXND1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10521671", "species_10521665" ], "products": [ "species_10521673" ], "modifiers": [], "additional_components": [ "O45657", "WBGene00004048", "U4PRY7", "WBGene00004047", "Q17330", "WBGene00004889", "Q95XP4", "WBGene00003111", "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "Q95XP4", "WBGene00003111", "Q9TYS4", "WBGene00004890", "O45657", "WBGene00004048", "U4PRY7", "WBGene00004047" ] }, "reaction_10524174": { "compartment": "compartment_876", "id": "reaction_10524174", "reactome": "R-CEL-434989", "name": "SEMA7A binds to PLXNC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10524170", "species_10524162" ], "products": [ "species_10524172" ], "modifiers": [], "additional_components": [ "Q17330", "WBGene00004889", "Q95XP4", "WBGene00003111", "Q9TYS4", "WBGene00004890", "U4PRY7", "WBGene00004047", "O45657", "WBGene00004048", "U4PRY7", "WBGene00004047", "O45657", "WBGene00004048", "Q17330", "WBGene00004889", "Q95XP4", "WBGene00003111", "Q9TYS4", "WBGene00004890" ] }, "reaction_10508448": { "compartment": "compartment_7660", "id": "reaction_10508448", "reactome": "R-CEL-109638", "name": "Recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10507139", "species_10504433" ], "products": [ "species_10507141" ], "modifiers": [], "additional_components": [ "Q95ZS0", "WBGene00006392", "Q9GZI6", "WBGene00006387", "G5EF68", "WBGene00006386", "O45784", "WBGene00006391", "P32085", "WBGene00006542", "O61707", "WBGene00006385", "Q9NEW8", "WBGene00006389", "Q9TYN3", "WBGene00006383", "Q18265", "WBGene00016173", "Q17957", "WBGene00006397", "E9P861", "WBGene00006384", "Q20361", "WBGene00006395", "G5EGM3", "WBGene00006382", "O44625", "WBGene00004136", "Q9NEX2", "WBGene00013736", "O16991", "WBGene00006648", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q95ZS0", "WBGene00006392", "Q9GZI6", "WBGene00006387", "G5EF68", "WBGene00006386", "O45784", "WBGene00006391", "P32085", "WBGene00006542", "O61707", "WBGene00006385", "Q9NEW8", "WBGene00006389", "Q9TYN3", "WBGene00006383", "Q18265", "WBGene00016173", "Q17957", "WBGene00006397", "E9P861", "WBGene00006384", "Q20361", "WBGene00006395", "G5EGM3", "WBGene00006382", "O44625", "WBGene00004136", "Q9NEX2", "WBGene00013736", "O16991", "WBGene00006648" ] }, "reaction_10508450": { "compartment": "compartment_7660", "id": "reaction_10508450", "reactome": "R-CEL-109639", "name": "Formation of the closed pre-initiation complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10506316", "species_10507143" ], "products": [ "species_10507432" ], "modifiers": [], "additional_components": [ "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "G5EG49", "WBGene00013998", "G5EG47", "WBGene00010054", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q95ZS0", "WBGene00006392", "Q9GZI6", "WBGene00006387", "G5EF68", "WBGene00006386", "O45784", "WBGene00006391", "P32085", "WBGene00006542", "O61707", "WBGene00006385", "Q9NEW8", "WBGene00006389", "Q9TYN3", "WBGene00006383", "Q18265", "WBGene00016173", "Q17957", "WBGene00006397", "E9P861", "WBGene00006384", "Q20361", "WBGene00006395", "G5EGM3", "WBGene00006382", "O44625", "WBGene00004136", "Q9NEX2", "WBGene00013736", "O16991", "WBGene00006648", "G5EG49", "WBGene00013998", "G5EG47", "WBGene00010054", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q95ZS0", "WBGene00006392", "Q9GZI6", "WBGene00006387", "G5EF68", "WBGene00006386", "O45784", "WBGene00006391", "P32085", "WBGene00006542", "O61707", "WBGene00006385", "Q9NEW8", "WBGene00006389", "Q9TYN3", "WBGene00006383", "Q18265", "WBGene00016173", "Q17957", "WBGene00006397", "E9P861", "WBGene00006384", "Q20361", "WBGene00006395", "G5EGM3", "WBGene00006382", "O44625", "WBGene00004136", "Q9NEX2", "WBGene00013736", "O16991", "WBGene00006648", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529" ] }, "reaction_10507145": { "compartment": "compartment_7660", "id": "reaction_10507145", "reactome": "R-CEL-75095", "name": "Binding of TFIIE to the growing preinitiation complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10507141", "species_10506528" ], "products": [ "species_10507143" ], "modifiers": [], "additional_components": [ "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q95ZS0", "WBGene00006392", "Q9GZI6", "WBGene00006387", "G5EF68", "WBGene00006386", "O45784", "WBGene00006391", "P32085", "WBGene00006542", "O61707", "WBGene00006385", "Q9NEW8", "WBGene00006389", "Q9TYN3", "WBGene00006383", "Q18265", "WBGene00016173", "Q17957", "WBGene00006397", "E9P861", "WBGene00006384", "Q20361", "WBGene00006395", "G5EGM3", "WBGene00006382", "O44625", "WBGene00004136", "Q9NEX2", "WBGene00013736", "O16991", "WBGene00006648", "G5EG49", "WBGene00013998", "G5EG47", "WBGene00010054", "G5EG49", "WBGene00013998", "G5EG47", "WBGene00010054", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q95ZS0", "WBGene00006392", "Q9GZI6", "WBGene00006387", "G5EF68", "WBGene00006386", "O45784", "WBGene00006391", "P32085", "WBGene00006542", "O61707", "WBGene00006385", "Q9NEW8", "WBGene00006389", "Q9TYN3", "WBGene00006383", "Q18265", "WBGene00016173", "Q17957", "WBGene00006397", "E9P861", "WBGene00006384", "Q20361", "WBGene00006395", "G5EGM3", "WBGene00006382", "O44625", "WBGene00004136", "Q9NEX2", "WBGene00013736", "O16991", "WBGene00006648" ] }, "reaction_10508444": { "compartment": "compartment_7660", "id": "reaction_10508444", "reactome": "R-CEL-109636", "name": "Recognition and Binding of Core Promoter Elements by TFIID", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109627", "species_10506516" ], "products": [ "species_10507137" ], "modifiers": [], "additional_components": [ "Q95ZS0", "WBGene00006392", "Q9GZI6", "WBGene00006387", "G5EF68", "WBGene00006386", "O45784", "WBGene00006391", "P32085", "WBGene00006542", "O61707", "WBGene00006385", "Q9NEW8", "WBGene00006389", "Q9TYN3", "WBGene00006383", "Q18265", "WBGene00016173", "Q17957", "WBGene00006397", "E9P861", "WBGene00006384", "Q20361", "WBGene00006395", "G5EGM3", "WBGene00006382", "Q95ZS0", "WBGene00006392", "Q9GZI6", "WBGene00006387", "G5EF68", "WBGene00006386", "O45784", "WBGene00006391", "P32085", "WBGene00006542", "O61707", "WBGene00006385", "Q9NEW8", "WBGene00006389", "Q9TYN3", "WBGene00006383", "Q18265", "WBGene00016173", "Q17957", "WBGene00006397", "E9P861", "WBGene00006384", "Q20361", "WBGene00006395", "G5EGM3", "WBGene00006382" ] }, "reaction_10508446": { "compartment": "compartment_7660", "id": "reaction_10508446", "reactome": "R-CEL-109637", "name": "Binding of TFIIA and TFIIB to the pol II promoter:TFIID complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10506438", "species_10506433", "species_10507137" ], "products": [ "species_10507139" ], "modifiers": [], "additional_components": [ "WBGene00006648", "O44625", "WBGene00004136", "Q9NEX2", "WBGene00013736", "Q95ZS0", "WBGene00006392", "Q9GZI6", "WBGene00006387", "G5EF68", "WBGene00006386", "O45784", "WBGene00006391", "P32085", "WBGene00006542", "O61707", "WBGene00006385", "Q9NEW8", "WBGene00006389", "Q9TYN3", "WBGene00006383", "Q18265", "WBGene00016173", "Q17957", "WBGene00006397", "E9P861", "WBGene00006384", "Q20361", "WBGene00006395", "G5EGM3", "WBGene00006382", "Q95ZS0", "WBGene00006392", "Q9GZI6", "WBGene00006387", "G5EF68", "WBGene00006386", "O45784", "WBGene00006391", "P32085", "WBGene00006542", "O61707", "WBGene00006385", "Q9NEW8", "WBGene00006389", "Q9TYN3", "WBGene00006383", "Q18265", "WBGene00016173", "Q17957", "WBGene00006397", "E9P861", "WBGene00006384", "Q20361", "WBGene00006395", "G5EGM3", "WBGene00006382", "O44625", "WBGene00004136", "Q9NEX2", "WBGene00013736", "O16991", "WBGene00006648" ] }, "reaction_10532932": { "compartment": "compartment_876", "id": "reaction_10532932", "reactome": "R-CEL-1299359", "name": "Activation of TALK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10532929", "catalyst" ] ], "additional_components": [ "O45891", "WBGene00006692", "G5ED42", "WBGene00006670", "Q65XY3", "WBGene00019904", "Q18261", "WBGene00016168", "G5EEH1", "WBGene00006693", "Q6BES3", "WBGene00006677", "Q19525", "WBGene00006661", "I2HAD3", "WBGene00006676", "Q93732", "WBGene00006681", "C0Z3L1", "WBGene00001190", "Q23435", "WBGene00006664" ] }, "reaction_10532792": { "compartment": "compartment_876", "id": "reaction_10532792", "reactome": "R-CEL-1296348", "name": "Activation of TWIK-related K+ channel (TREK)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10532789", "catalyst" ] ], "additional_components": [ "G5ECW6", "WBGene00006673", "O17185", "WBGene00006318" ] }, "reaction_10532802": { "compartment": "compartment_876", "id": "reaction_10532802", "reactome": "R-CEL-1299297", "name": "Activation of THIK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10532799", "catalyst" ] ], "additional_components": [ "F5GUD1", "WBGene00006669" ] }, "reaction_10532833": { "compartment": "compartment_876", "id": "reaction_10532833", "reactome": "R-CEL-1299304", "name": "Activation of tandem pore domain in a weak inwardly rectifying K+ channels", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10532830", "catalyst" ] ], "additional_components": [ "Q10937", "WBGene00015137", "Q9NEV3", "WBGene00006696" ] }, "reaction_10532854": { "compartment": "compartment_876", "id": "reaction_10532854", "reactome": "R-CEL-1299318", "name": "Activation of TASK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10532851", "catalyst" ] ], "additional_components": [ "G5ECW6", "WBGene00006673", "O17185", "WBGene00006318" ] }, "reaction_10532864": { "compartment": "compartment_876", "id": "reaction_10532864", "reactome": "R-CEL-1299338", "name": "Activation of TRESK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10532861", "catalyst" ] ], "additional_components": [ "Q22043", "WBGene00006675" ] }, "reaction_10532761": { "compartment": "compartment_876", "id": "reaction_10532761", "reactome": "R-CEL-1296046", "name": "KCNJs transport K+ from the extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74126" ], "products": [ "species_29804" ], "modifiers": [ [ "species_10532758", "catalyst" ] ], "additional_components": [ "P52192", "WBGene00002149", "A0A1C3NSK2", "WBGene00002151", "A0A1C3NSN6", "WBGene00002150" ] }, "reaction_10532746": { "compartment": "compartment_876", "id": "reaction_10532746", "reactome": "R-CEL-1296045", "name": "Activation of Potassium transport channels", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10532743", "catalyst" ] ], "additional_components": [ "P52192", "WBGene00002149", "A0A1C3NSK2", "WBGene00002151", "A0A1C3NSN6", "WBGene00002150" ] }, "reaction_10566209": { "compartment": "compartment_7660", "id": "reaction_10566209", "reactome": "R-CEL-8865454", "name": "CBFB binds RUNX3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10566205", "species_10566197" ], "products": [ "species_10566207" ], "modifiers": [], "additional_components": [ "WBGene00004393", "WBGene00000272", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393" ] }, "reaction_10568338": { "compartment": "compartment_70101", "id": "reaction_10568338", "reactome": "R-CEL-8937792", "name": "RUNX3 binds SRC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10568334", "species_10518187" ], "products": [ "species_10568336" ], "modifiers": [], "additional_components": [ "WBGene00004393", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "G5EFQ5", "WBGene00004393" ] }, "reaction_10569702": { "compartment": "compartment_7660", "id": "reaction_10569702", "reactome": "R-CEL-8952399", "name": "Polyubiquitinated RUNX3 translocates to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10569698" ], "products": [ "species_10569700" ], "modifiers": [], "additional_components": [ "WBGene00004393", "WBGene00004393" ] }, "reaction_10568344": { "compartment": "compartment_70101", "id": "reaction_10568344", "reactome": "R-CEL-8937807", "name": "SRC phosphorylates RUNX3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10568336" ], "products": [ "species_10518187", "species_29370", "species_10568341" ], "modifiers": [ [ "species_10568336", "catalyst" ] ], "additional_components": [ "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "G5EFQ5", "WBGene00004393", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "WBGene00004393", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "G5EFQ5", "WBGene00004393" ] }, "reaction_10569704": { "compartment": "compartment_70101", "id": "reaction_10569704", "reactome": "R-CEL-8952408", "name": "Polyubiquitinated RUNX3 is degraded by the proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10569700" ], "products": [ "species_10502375" ], "modifiers": [ [ "species_10512606", "catalyst" ] ], "additional_components": [ "WBGene00004393", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "Q23237", "WBGene00003949", "P90868", "WBGene00003953", "Q9XUV0", "WBGene00003951", "Q966I8", "WBGene00003947", "O62102", "WBGene00003948", "O16368", "WBGene00004502", "Q18787", "WBGene00004501", "O76371", "WBGene00004505", "P46502", "WBGene00004503", "Q9XTT9", "WBGene00004506", "O17071", "WBGene00004504", "Q18115", "WBGene00004459", "Q20938", "WBGene00004462", "Q19324", "WBGene00004461", "Q22253", "WBGene00004465", "Q9GZH5", "WBGene00004458", "Q04908", "WBGene00004460", "O61742", "WBGene00004466", "O76577", "WBGene00004467", "Q20058", "WBGene00009445", "O44156", "WBGene00003927", "Q20585", "WBGene00004463", "Q27488", "WBGene00003923", "O61792", "WBGene00004464", "Q09583", "WBGene00003928", "Q23449", "WBGene00004468", "Q9N599", "WBGene00003924", "Q10920", "WBGene00016623", "Q95008", "WBGene00003926", "Q95PZ7", "WBGene00013435", "O17586", "WBGene00003922", "Q95005", "WBGene00003925", "P34286", "WBGene00003952", "P91477", "WBGene00003950" ] }, "reaction_10568346": { "compartment": "compartment_70101", "id": "reaction_10568346", "reactome": "R-CEL-8937814", "name": "RUNX3 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10568334" ], "products": [ "species_10566205" ], "modifiers": [ [ "species_10511431", "catalyst" ], [ "species_10518187", "inhibitor" ] ], "additional_components": [ "WBGene00004393", "WBGene00004393", "G5EBY8", "WBGene00006852", "G5EEL5", "WBGene00000936", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635" ] }, "reaction_10518768": { "compartment": "compartment_876", "id": "reaction_10518768", "reactome": "R-CEL-374686", "name": "L1 interaction with Integrins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10518718", "species_10518764" ], "products": [ "species_10518766" ], "modifiers": [], "additional_components": [ "Q21465", "WBGene00019727", "Q5WRR1", "WBGene00006942", "P34446", "WBGene00003929", "Q27874", "WBGene00003930", "P34446", "WBGene00003929", "Q27874", "WBGene00003930", "Q21465", "WBGene00019727", "Q5WRR1", "WBGene00006942" ] }, "reaction_10524706": { "compartment": "compartment_70101", "id": "reaction_10524706", "reactome": "R-CEL-445064", "name": "Activation of Rac1 by VAV2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10520575", "species_29438" ], "products": [ "species_29420", "species_10509457" ], "modifiers": [ [ "species_10524306", "catalyst" ] ], "additional_components": [ "species_29420", "Q03206", "ced-10", "species_29438", "Q03206", "ced-10", "WBGene00006887" ] }, "reaction_10524710": { "compartment": "compartment_876", "id": "reaction_10524710", "reactome": "R-CEL-445069", "name": "L1-EGFR trans-heterodimerization", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10518718", "species_10512185" ], "products": [ "species_10524708" ], "modifiers": [], "additional_components": [ "Q21465", "WBGene00019727", "Q5WRR1", "WBGene00006942", "WBGene00002299", "P24348", "WBGene00002299", "Q21465", "WBGene00019727", "Q5WRR1", "WBGene00006942" ] }, "reaction_10521079": { "compartment": "compartment_70101", "id": "reaction_10521079", "reactome": "R-CEL-392752", "name": "Phosphorylation of L1 by CK-II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10518718", "species_10515097", "species_113592" ], "products": [ "species_29370", "species_10521077" ], "modifiers": [ [ "species_10515097", "catalyst" ] ], "additional_components": [ "Q21465", "WBGene00019727", "Q5WRR1", "WBGene00006942", "P18334", "WBGene00002191", "P28548", "WBGene00002196", "Q5WRR1", "WBGene00006942", "Q21465", "WBGene00019727", "P18334", "WBGene00002191", "P28548", "WBGene00002196", "P18334", "WBGene00002191", "P28548", "WBGene00002196" ] }, "reaction_10518762": { "compartment": "compartment_876", "id": "reaction_10518762", "reactome": "R-CEL-374681", "name": "L1 and NCAM1 engaged in cis-interaction", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10518718", "species_10518758" ], "products": [ "species_10518760" ], "modifiers": [], "additional_components": [ "Q21465", "WBGene00019727", "Q5WRR1", "WBGene00006942", "WBGene00004372", "C6KRM7", "WBGene00004372", "Q21465", "WBGene00019727", "Q5WRR1", "WBGene00006942" ] }, "reaction_10524715": { "compartment": "compartment_70101", "id": "reaction_10524715", "reactome": "R-CEL-445072", "name": "Interaction of PAK1 with Rac1-GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10509457", "species_10520672" ], "products": [ "species_10520670", "species_29370", "species_10524712" ], "modifiers": [ [ "species_10520670", "catalyst" ] ], "additional_components": [ "species_29438", "Q03206", "ced-10", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "species_29438", "Q03206", "ced-10", "Q17850", "WBGene00003911", "G5EGQ3", "WBGene00003144", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911" ] }, "reaction_10516546": { "compartment": "compartment_984", "id": "reaction_10516546", "reactome": "R-CEL-210404", "name": "SLC1A1-3,6,7 exchange L-Glu, H+ and 3Na+ for K+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_210382", "species_29804", "species_74113" ], "products": [ "species_74126", "species_29404", "species_70106", "species_83910" ], "modifiers": [ [ "species_10516538", "catalyst" ], [ "species_10516544", "inhibitor" ] ], "additional_components": [ "Q21353", "WBGene00001621", "Q21751", "WBGene00001624", "Q22682", "WBGene00001622", "Q9UAY8", "WBGene00001625", "O18210", "WBGene00001623", "Q10901", "WBGene00001620", "WBGene00017070" ] }, "reaction_10516838": { "compartment": "compartment_70101", "id": "reaction_10516838", "reactome": "R-CEL-210444", "name": "L-Glutamate loading of synaptic vesicle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29404", "species_10516835" ], "products": [ "species_10516719" ], "modifiers": [ [ "species_10516835", "catalyst" ] ], "additional_components": [ "P34644", "WBGene00001135", "Q10046", "WBGene00011556", "G5EEK1", "WBGene00010755", "Q94986", "WBGene00004267", "Q19136", "WBGene00006306", "K8FE10", "WBGene00004922", "Q23056", "WBGene00020861", "O16700", "WBGene00004925", "Q965S5", "WBGene00004923", "P34693", "WBGene00004921", "Q19767", "WBGene00004898", "G5EBK2", "WBGene00014084", "Q94057", "WBGene00044062", "O02495", "WBGene00004897", "Q95XH1", "WBGene00022077", "P34351", "WBGene00004899", "P34644", "WBGene00001135", "Q10046", "WBGene00011556", "G5EEK1", "WBGene00010755", "Q94986", "WBGene00004267", "Q19136", "WBGene00006306", "K8FE10", "WBGene00004922", "Q23056", "WBGene00020861", "O16700", "WBGene00004925", "Q965S5", "WBGene00004923", "P34693", "WBGene00004921", "Q19767", "WBGene00004898", "G5EBK2", "WBGene00014084", "Q94057", "WBGene00044062", "O02495", "WBGene00004897", "Q95XH1", "WBGene00022077", "P34351", "WBGene00004899", "species_113552", "P34644", "WBGene00001135", "Q10046", "WBGene00011556", "G5EEK1", "WBGene00010755", "Q94986", "WBGene00004267", "Q19136", "WBGene00006306", "K8FE10", "WBGene00004922", "Q23056", "WBGene00020861", "O16700", "WBGene00004925", "Q965S5", "WBGene00004923", "P34693", "WBGene00004921", "Q19767", "WBGene00004898", "G5EBK2", "WBGene00014084", "Q94057", "WBGene00044062", "O02495", "WBGene00004897", "Q95XH1", "WBGene00022077", "P34351", "WBGene00004899" ] }, "reaction_10516828": { "compartment": "compartment_984", "id": "reaction_10516828", "reactome": "R-CEL-210430", "name": "Release of L-Glutamate at the synapse", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10516779", "species_74016" ], "products": [ "species_210382", "species_10516825", "species_10516777", "species_10516809", "species_10516744", "species_10516823", "species_10516631", "species_10516791" ], "modifiers": [ [ "species_10516779", "catalyst" ], [ "species_74016", "catalyst" ] ], "additional_components": [ "G5EEN8", "WBGene00006454", "A5PEW5", "WBGene00004364", "P34815", "WBGene00006757", "Q9GUM7", "WBGene00022271", "Q21049", "WBGene00006364", "Q22366", "WBGene00006750", "P27715", "WBGene00006752", "Q9N415", "WBGene00006513", "O16000", "WBGene00006798", "P34644", "WBGene00001135", "Q10046", "WBGene00011556", "G5EEK1", "WBGene00010755", "Q94986", "WBGene00004267", "Q19136", "WBGene00006306", "K8FE10", "WBGene00004922", "Q23056", "WBGene00020861", "O16700", "WBGene00004925", "Q965S5", "WBGene00004923", "P34693", "WBGene00004921", "Q19767", "WBGene00004898", "G5EBK2", "WBGene00014084", "Q94057", "WBGene00044062", "O02495", "WBGene00004897", "Q95XH1", "WBGene00022077", "P34351", "WBGene00004899", "species_113552", "WBGene00004267", "Q21049", "WBGene00006364", "Q22366", "WBGene00006750", "P27715", "WBGene00006752", "Q9N415", "WBGene00006513", "species_74016", "G5EEN8", "WBGene00006454", "A5PEW5", "WBGene00004364", "Q94057", "WBGene00044062", "Q95XH1", "WBGene00022077", "G5EBK2", "WBGene00014084", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q19767", "WBGene00004898", "O16000", "WBGene00006798", "WBGene00022271", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "WBGene00006757", "G5EEK1", "WBGene00010755", "P34644", "WBGene00001135", "Q10046", "WBGene00011556", "G5EEN8", "WBGene00006454", "A5PEW5", "WBGene00004364", "P34815", "WBGene00006757", "Q9GUM7", "WBGene00022271", "Q21049", "WBGene00006364", "Q22366", "WBGene00006750", "P27715", "WBGene00006752", "Q9N415", "WBGene00006513", "O16000", "WBGene00006798", "P34644", "WBGene00001135", "Q10046", "WBGene00011556", "G5EEK1", "WBGene00010755", "Q94986", "WBGene00004267", "Q19136", "WBGene00006306", "K8FE10", "WBGene00004922", "Q23056", "WBGene00020861", "O16700", "WBGene00004925", "Q965S5", "WBGene00004923", "P34693", "WBGene00004921", "Q19767", "WBGene00004898", "G5EBK2", "WBGene00014084", "Q94057", "WBGene00044062", "O02495", "WBGene00004897", "Q95XH1", "WBGene00022077", "P34351", "WBGene00004899", "species_113552" ] }, "reaction_10516782": { "compartment": "compartment_70101", "id": "reaction_10516782", "reactome": "R-CEL-210426", "name": "Glutamate synaptic vesicle docking and priming", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10516719", "species_10516749", "species_10516777", "species_10516744", "species_10516631", "species_10516739" ], "products": [ "species_10516779" ], "modifiers": [ [ "species_10516719", "catalyst" ], [ "species_10516759", "catalyst" ] ], "additional_components": [ "P34644", "WBGene00001135", "Q10046", "WBGene00011556", "G5EEK1", "WBGene00010755", "Q94986", "WBGene00004267", "Q19136", "WBGene00006306", "K8FE10", "WBGene00004922", "Q23056", "WBGene00020861", "O16700", "WBGene00004925", "Q965S5", "WBGene00004923", "P34693", "WBGene00004921", "Q19767", "WBGene00004898", "G5EBK2", "WBGene00014084", "Q94057", "WBGene00044062", "O02495", "WBGene00004897", "Q95XH1", "WBGene00022077", "P34351", "WBGene00004899", "species_113552", "WBGene00006798", "Q21049", "WBGene00006364", "Q22366", "WBGene00006750", "P27715", "WBGene00006752", "Q9N415", "WBGene00006513", "WBGene00022271", "WBGene00006757", "G5EEN8", "WBGene00006454", "A5PEW5", "WBGene00004364", "G5EEN8", "WBGene00006454", "A5PEW5", "WBGene00004364", "P34815", "WBGene00006757", "Q9GUM7", "WBGene00022271", "Q21049", "WBGene00006364", "Q22366", "WBGene00006750", "P27715", "WBGene00006752", "Q9N415", "WBGene00006513", "O16000", "WBGene00006798", "P34644", "WBGene00001135", "Q10046", "WBGene00011556", "G5EEK1", "WBGene00010755", "Q94986", "WBGene00004267", "Q19136", "WBGene00006306", "K8FE10", "WBGene00004922", "Q23056", "WBGene00020861", "O16700", "WBGene00004925", "Q965S5", "WBGene00004923", "P34693", "WBGene00004921", "Q19767", "WBGene00004898", "G5EBK2", "WBGene00014084", "Q94057", "WBGene00044062", "O02495", "WBGene00004897", "Q95XH1", "WBGene00022077", "P34351", "WBGene00004899", "species_113552", "P34644", "WBGene00001135", "Q10046", "WBGene00011556", "G5EEK1", "WBGene00010755", "Q94986", "WBGene00004267", "Q19136", "WBGene00006306", "K8FE10", "WBGene00004922", "Q23056", "WBGene00020861", "O16700", "WBGene00004925", "Q965S5", "WBGene00004923", "P34693", "WBGene00004921", "Q19767", "WBGene00004898", "G5EBK2", "WBGene00014084", "Q94057", "WBGene00044062", "O02495", "WBGene00004897", "Q95XH1", "WBGene00022077", "P34351", "WBGene00004899", "species_113552", "WBGene00006752" ] }, "reaction_10543028": { "compartment": "compartment_5460", "id": "reaction_10543028", "reactome": "R-CEL-2162186", "name": "DeMQ10H2 is methylated to Q10H2 by COQ3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2162265", "species_2162212" ], "products": [ "species_2162252", "species_113529", "species_2162198" ], "modifiers": [ [ "species_10543025", "catalyst" ] ], "additional_components": [ "WBGene00000763" ] }, "reaction_10543036": { "compartment": "compartment_70616", "id": "reaction_10543036", "reactome": "R-CEL-2162192", "name": "PHB and all-E-10PrP2 are combined into DHB by COQ2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2162214", "species_2162213" ], "products": [ "species_2162207", "species_159450" ], "modifiers": [ [ "species_10543033", "catalyst" ] ], "additional_components": [ "WBGene00000762" ] }, "reaction_10543039": { "compartment": "compartment_5460", "id": "reaction_10543039", "reactome": "R-CEL-2162193", "name": "DHDB is methylated to MHDB by COQ3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2162265", "species_2162209" ], "products": [ "species_2162252", "species_113529", "species_2162215" ], "modifiers": [ [ "species_10543025", "catalyst" ] ], "additional_components": [ "WBGene00000763" ] }, "reaction_10518304": { "compartment": "compartment_70101", "id": "reaction_10518304", "reactome": "R-CEL-372505", "name": "Acetylcholine synaptic vesicle docking and priming", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10517503", "species_10516749", "species_10516777", "species_10516744", "species_10516631", "species_10516739" ], "products": [ "species_10518301" ], "modifiers": [ [ "species_10517503", "catalyst" ] ], "additional_components": [ "species_372533", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "P34711", "WBGene00006756", "Q19767", "WBGene00004898", "G5EBK2", "WBGene00014084", "Q94057", "WBGene00044062", "O02495", "WBGene00004897", "Q95XH1", "WBGene00022077", "P34351", "WBGene00004899", "Q94986", "WBGene00004267", "WBGene00006798", "Q21049", "WBGene00006364", "Q22366", "WBGene00006750", "P27715", "WBGene00006752", "Q9N415", "WBGene00006513", "WBGene00022271", "WBGene00006757", "G5EEN8", "WBGene00006454", "A5PEW5", "WBGene00004364", "G5EEN8", "WBGene00006454", "A5PEW5", "WBGene00004364", "P34815", "WBGene00006757", "Q9GUM7", "WBGene00022271", "Q21049", "WBGene00006364", "Q22366", "WBGene00006750", "P27715", "WBGene00006752", "Q9N415", "WBGene00006513", "O16000", "WBGene00006798", "species_372533", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "P34711", "WBGene00006756", "Q19767", "WBGene00004898", "G5EBK2", "WBGene00014084", "Q94057", "WBGene00044062", "O02495", "WBGene00004897", "Q95XH1", "WBGene00022077", "P34351", "WBGene00004899", "Q94986", "WBGene00004267", "species_372533", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "P34711", "WBGene00006756", "Q19767", "WBGene00004898", "G5EBK2", "WBGene00014084", "Q94057", "WBGene00044062", "O02495", "WBGene00004897", "Q95XH1", "WBGene00022077", "P34351", "WBGene00004899", "Q94986", "WBGene00004267" ] }, "reaction_10518401": { "compartment": "compartment_876", "id": "reaction_10518401", "reactome": "R-CEL-372529", "name": "Release of acetylcholine at the synapse", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10518301" ], "products": [ "species_10518398", "species_10516825", "species_10516777", "species_10516744", "species_10516823", "species_10516631", "species_10516807", "species_372533" ], "modifiers": [ [ "species_10518301", "catalyst" ] ], "additional_components": [ "G5EEN8", "WBGene00006454", "A5PEW5", "WBGene00004364", "P34815", "WBGene00006757", "Q9GUM7", "WBGene00022271", "Q21049", "WBGene00006364", "Q22366", "WBGene00006750", "P27715", "WBGene00006752", "Q9N415", "WBGene00006513", "O16000", "WBGene00006798", "species_372533", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "P34711", "WBGene00006756", "Q19767", "WBGene00004898", "G5EBK2", "WBGene00014084", "Q94057", "WBGene00044062", "O02495", "WBGene00004897", "Q95XH1", "WBGene00022077", "P34351", "WBGene00004899", "Q94986", "WBGene00004267", "WBGene00006756", "WBGene00004267", "Q21049", "WBGene00006364", "Q22366", "WBGene00006750", "P27715", "WBGene00006752", "Q9N415", "WBGene00006513", "WBGene00022271", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "WBGene00006757", "G5EEN8", "WBGene00006454", "A5PEW5", "WBGene00004364", "Q94057", "WBGene00044062", "Q95XH1", "WBGene00022077", "G5EBK2", "WBGene00014084", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q19767", "WBGene00004898", "O16000", "WBGene00006798", "G5EEN8", "WBGene00006454", "A5PEW5", "WBGene00004364", "P34815", "WBGene00006757", "Q9GUM7", "WBGene00022271", "Q21049", "WBGene00006364", "Q22366", "WBGene00006750", "P27715", "WBGene00006752", "Q9N415", "WBGene00006513", "O16000", "WBGene00006798", "species_372533", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "P34711", "WBGene00006756", "Q19767", "WBGene00004898", "G5EBK2", "WBGene00014084", "Q94057", "WBGene00044062", "O02495", "WBGene00004897", "Q95XH1", "WBGene00022077", "P34351", "WBGene00004899", "Q94986", "WBGene00004267" ] }, "reaction_10517506": { "compartment": "compartment_70101", "id": "reaction_10517506", "reactome": "R-CEL-264615", "name": "Loading of acetylcholine in synaptic vesicles", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10517501", "species_372511", "species_264643" ], "products": [ "species_10517503", "species_70106" ], "modifiers": [ [ "species_10517483", "catalyst" ] ], "additional_components": [ "P34711", "WBGene00006756", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "Q19767", "WBGene00004898", "G5EBK2", "WBGene00014084", "Q94057", "WBGene00044062", "O02495", "WBGene00004897", "Q95XH1", "WBGene00022077", "P34351", "WBGene00004899", "Q94986", "WBGene00004267", "species_372533", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "P34711", "WBGene00006756", "Q19767", "WBGene00004898", "G5EBK2", "WBGene00014084", "Q94057", "WBGene00044062", "O02495", "WBGene00004897", "Q95XH1", "WBGene00022077", "P34351", "WBGene00004899", "Q94986", "WBGene00004267", "WBGene00006756" ] }, "reaction_10517514": { "compartment": "compartment_70101", "id": "reaction_10517514", "reactome": "R-CEL-264622", "name": "Cho is acetylated to AcCho by CHAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_264618", "species_76183" ], "products": [ "species_264643", "species_76194" ], "modifiers": [ [ "species_10517511", "catalyst" ] ], "additional_components": [ "WBGene00000481" ] }, "reaction_10554130": { "compartment": "compartment_18730", "id": "reaction_10554130", "reactome": "R-CEL-5638004", "name": "RP2 binds ARL3:GTP:UNC119B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10554126", "species_10554121" ], "products": [ "species_10554128" ], "modifiers": [], "additional_components": [ "WBGene00019536", "species_29438", "O45379", "WBGene00000188", "Q10658", "WBGene00006843", "species_29438", "O45379", "WBGene00000188", "Q10658", "WBGene00006843", "Q966I6", "WBGene00019536" ] }, "reaction_10554148": { "compartment": "compartment_18730", "id": "reaction_10554148", "reactome": "R-CEL-5638016", "name": "RP2:ARL3:GDP:UNC119B dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10554134" ], "products": [ "species_10554126", "species_10554119", "species_10554132" ], "modifiers": [], "additional_components": [ "O45379", "WBGene00000188", "species_29420", "Q10658", "WBGene00006843", "Q966I6", "WBGene00019536", "WBGene00019536", "WBGene00006843", "O45379", "WBGene00000188", "species_29420" ] }, "reaction_10554137": { "compartment": "compartment_18730", "id": "reaction_10554137", "reactome": "R-CEL-5638006", "name": "ARL3 hydrolyzes GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10554128" ], "products": [ "species_10554134" ], "modifiers": [ [ "species_10554128", "catalyst" ] ], "additional_components": [ "species_29438", "O45379", "WBGene00000188", "Q10658", "WBGene00006843", "Q966I6", "WBGene00019536", "O45379", "WBGene00000188", "species_29420", "Q10658", "WBGene00006843", "Q966I6", "WBGene00019536", "species_29438", "O45379", "WBGene00000188", "Q10658", "WBGene00006843", "Q966I6", "WBGene00019536" ] }, "reaction_10554140": { "compartment": "compartment_18730", "id": "reaction_10554140", "reactome": "R-CEL-5638007", "name": "RP2 activates the GTPase activity of ARL3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10554128" ], "products": [ "species_10554128" ], "modifiers": [ [ "species_10554126", "catalyst" ] ], "additional_components": [ "species_29438", "O45379", "WBGene00000188", "Q10658", "WBGene00006843", "Q966I6", "WBGene00019536", "species_29438", "O45379", "WBGene00000188", "Q10658", "WBGene00006843", "Q966I6", "WBGene00019536", "WBGene00019536" ] }, "reaction_10553222": { "compartment": "compartment_261122", "id": "reaction_10553222", "reactome": "R-CEL-5623527", "name": "VxPx-containing ciliary membrane proteins are delivered to the ciliary membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10553196" ], "products": [ "species_10553220" ], "modifiers": [], "additional_components": [ "Q03611", "WBGene00006526", "Q7Z205", "WBGene00000563", "Q9N4C1", "WBGene00022295", "A8WI01", "WBGene00000562", "O61827", "WBGene00000487", "G5EEE2", "WBGene00006525", "O01803", "WBGene00004274", "species_29438", "Q95ZS6", "WBGene00018869", "Q20759", "WBGene00010045", "G5EFC1", "WBGene00004272", "Q21137", "WBGene00019317", "Q9XWS2", "WBGene00004753", "Q18406", "WBGene00016376", "Q18286", "WBGene00016188", "P91149", "WBGene00016606", "Q95Q35", "WBGene00013687", "Q20678", "WBGene00018703", "Q22706", "WBGene00004752", "Q19262", "WBGene00017284", "Q03611", "WBGene00006526", "A8WI01", "WBGene00000562", "O61827", "WBGene00000487", "Q7Z205", "WBGene00000563", "Q9N4C1", "WBGene00022295", "G5EEE2", "WBGene00006525" ] }, "reaction_10553129": { "compartment": "compartment_70101", "id": "reaction_10553129", "reactome": "R-CEL-5623508", "name": "GBF1 stimulates nucleotide exchange on ARF4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10553127" ], "products": [ "species_10553068", "species_29420" ], "modifiers": [ [ "species_10517992", "catalyst" ] ], "additional_components": [ "Q94231", "WBGene00000190", "species_29420", "Q94231", "WBGene00000190", "species_29438", "WBGene00007703" ] }, "reaction_10553198": { "compartment": "compartment_13949", "id": "reaction_10553198", "reactome": "R-CEL-5623524", "name": "The exocyst complex binds to RAB3IP in the ciliary targeting complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10553194", "species_10553176" ], "products": [ "species_10553196" ], "modifiers": [], "additional_components": [ "Q9XWS2", "WBGene00004753", "Q18406", "WBGene00016376", "Q18286", "WBGene00016188", "P91149", "WBGene00016606", "Q95Q35", "WBGene00013687", "Q20678", "WBGene00018703", "Q22706", "WBGene00004752", "Q19262", "WBGene00017284", "Q03611", "WBGene00006526", "Q7Z205", "WBGene00000563", "Q9N4C1", "WBGene00022295", "A8WI01", "WBGene00000562", "O61827", "WBGene00000487", "G5EEE2", "WBGene00006525", "O01803", "WBGene00004274", "species_29438", "Q95ZS6", "WBGene00018869", "Q20759", "WBGene00010045", "G5EFC1", "WBGene00004272", "Q21137", "WBGene00019317", "Q03611", "WBGene00006526", "Q7Z205", "WBGene00000563", "Q9N4C1", "WBGene00022295", "A8WI01", "WBGene00000562", "O61827", "WBGene00000487", "G5EEE2", "WBGene00006525", "O01803", "WBGene00004274", "species_29438", "Q95ZS6", "WBGene00018869", "Q20759", "WBGene00010045", "G5EFC1", "WBGene00004272", "Q21137", "WBGene00019317", "Q9XWS2", "WBGene00004753", "Q18406", "WBGene00016376", "Q18286", "WBGene00016188", "P91149", "WBGene00016606", "Q95Q35", "WBGene00013687", "Q20678", "WBGene00018703", "Q22706", "WBGene00004752", "Q19262", "WBGene00017284" ] }, "reaction_10553265": { "compartment": "compartment_70101", "id": "reaction_10553265", "reactome": "R-CEL-5624125", "name": "Formation of the BBSome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10552766", "species_10552796", "species_10552781", "species_10552776", "species_10552791", "species_10552786", "species_10552771", "species_10552801" ], "products": [ "species_10552803" ], "modifiers": [], "additional_components": [ "WBGene00000241", "WBGene00000244", "WBGene00010974", "WBGene00043992", "WBGene00016744", "WBGene00003892", "WBGene00000242", "WBGene00019482", "Q21273", "WBGene00019482", "Q19640", "WBGene00000242", "Q9XW70", "WBGene00003892", "O01514", "WBGene00016744", "Q5CZ52", "WBGene00043992", "Q21626", "WBGene00010974", "Q23049", "WBGene00000244", "Q9NEZ7", "WBGene00000241" ] }, "reaction_10553298": { "compartment": "compartment_876", "id": "reaction_10553298", "reactome": "R-CEL-5624126", "name": "ARL6:GTP and the BBSome bind ciliary cargo", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10553294", "species_10553272", "species_10552803" ], "products": [ "species_10553296" ], "modifiers": [], "additional_components": [ "H9G358", "WBGene00018089", "P34311", "WBGene00018089", "Q09502", "WBGene00008065", "Q20841", "WBGene00018886", "Q23033", "WBGene00020086", "A0A0K3AXD3", "WBGene00011372", "Q9XVQ0", "WBGene00018089", "A0A2C9C3A4", "WBGene00018089", "A0A3B1DQQ4", "WBGene00006864", "Q18510", "WBGene00000193", "species_29438", "Q21273", "WBGene00019482", "Q19640", "WBGene00000242", "Q9XW70", "WBGene00003892", "O01514", "WBGene00016744", "Q5CZ52", "WBGene00043992", "Q21626", "WBGene00010974", "Q23049", "WBGene00000244", "Q9NEZ7", "WBGene00000241", "Q21273", "WBGene00019482", "Q19640", "WBGene00000242", "Q9XW70", "WBGene00003892", "O01514", "WBGene00016744", "Q5CZ52", "WBGene00043992", "Q21626", "WBGene00010974", "Q23049", "WBGene00000244", "Q9NEZ7", "WBGene00000241", "Q18510", "WBGene00000193", "species_29438", "H9G358", "WBGene00018089", "P34311", "WBGene00018089", "Q09502", "WBGene00008065", "Q20841", "WBGene00018886", "Q23033", "WBGene00020086", "A0A0K3AXD3", "WBGene00011372", "Q9XVQ0", "WBGene00018089", "A0A2C9C3A4", "WBGene00018089", "A0A3B1DQQ4", "WBGene00006864" ] }, "reaction_10553354": { "compartment": "compartment_261122", "id": "reaction_10553354", "reactome": "R-CEL-5624127", "name": "ARL6:GTP and the BBSome target cargo to the primary cilium", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10553296" ], "products": [ "species_10553346" ], "modifiers": [ [ "species_10553352", "inhibitor" ] ], "additional_components": [ "Q21273", "WBGene00019482", "Q19640", "WBGene00000242", "Q9XW70", "WBGene00003892", "O01514", "WBGene00016744", "Q5CZ52", "WBGene00043992", "Q21626", "WBGene00010974", "Q23049", "WBGene00000244", "Q9NEZ7", "WBGene00000241", "Q18510", "WBGene00000193", "species_29438", "H9G358", "WBGene00018089", "P34311", "WBGene00018089", "Q09502", "WBGene00008065", "Q20841", "WBGene00018886", "Q23033", "WBGene00020086", "A0A0K3AXD3", "WBGene00011372", "Q9XVQ0", "WBGene00018089", "A0A2C9C3A4", "WBGene00018089", "A0A3B1DQQ4", "WBGene00006864", "species_29438", "Q18510", "WBGene00000193", "Q21273", "WBGene00019482", "Q19640", "WBGene00000242", "Q9XW70", "WBGene00003892", "O01514", "WBGene00016744", "Q5CZ52", "WBGene00043992", "Q21626", "WBGene00010974", "Q23049", "WBGene00000244", "Q9NEZ7", "WBGene00000241", "Q20841", "WBGene00018886", "Q23033", "WBGene00020086", "A0A0K3AXD3", "WBGene00011372", "Q9XVQ0", "WBGene00018089", "A0A2C9C3A4", "WBGene00018089", "A0A3B1DQQ4", "WBGene00006864", "H9G358", "WBGene00018089", "P34311", "WBGene00018089", "Q09502", "WBGene00008065", "Q21273", "WBGene00019482", "Q19640", "WBGene00000242", "Q9XW70", "WBGene00003892", "O01514", "WBGene00016744", "Q5CZ52", "WBGene00043992", "Q21626", "WBGene00010974", "Q23049", "WBGene00000244", "Q9NEZ7", "WBGene00000241" ] }, "reaction_10552812": { "compartment": "compartment_2132649", "id": "reaction_10552812", "reactome": "R-CEL-5617815", "name": "BBSome binds RAB3IP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10552808", "species_10552803" ], "products": [ "species_10552810" ], "modifiers": [], "additional_components": [ "WBGene00010045", "Q21273", "WBGene00019482", "Q19640", "WBGene00000242", "Q9XW70", "WBGene00003892", "O01514", "WBGene00016744", "Q5CZ52", "WBGene00043992", "Q21626", "WBGene00010974", "Q23049", "WBGene00000244", "Q9NEZ7", "WBGene00000241", "Q21273", "WBGene00019482", "Q19640", "WBGene00000242", "Q9XW70", "WBGene00003892", "O01514", "WBGene00016744", "Q5CZ52", "WBGene00043992", "Q21626", "WBGene00010974", "Q23049", "WBGene00000244", "Q9NEZ7", "WBGene00000241", "Q20759", "WBGene00010045" ] }, "reaction_10521804": { "compartment": "compartment_70101", "id": "reaction_10521804", "reactome": "R-CEL-418456", "name": "cGMP is degraded by PDEs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30991" ], "products": [ "species_113578" ], "modifiers": [ [ "species_10521801", "catalyst" ] ], "additional_components": [ "P30645", "WBGene00011146", "P91119", "WBGene00016328", "O18696", "WBGene00011433" ] }, "reaction_10514144": { "compartment": "compartment_70101", "id": "reaction_10514144", "reactome": "R-CEL-198845", "name": "CYB5A:heme reduces Asc.- to AscH-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1497805", "species_10514130" ], "products": [ "species_198816", "species_10514128" ], "modifiers": [ [ "species_10514130", "catalyst" ] ], "additional_components": [ "species_71185", "O01816", "WBGene00020931", "Q93315", "WBGene00007848", "CHEBI:36144", "O01816", "WBGene00020931", "Q93315", "WBGene00007848", "species_71185", "O01816", "WBGene00020931", "Q93315", "WBGene00007848" ] }, "reaction_10514114": { "compartment": "compartment_876", "id": "reaction_10514114", "reactome": "R-CEL-198818", "name": "SLC2A1,3 transports DeHA from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_198852" ], "products": [ "species_198827" ], "modifiers": [ [ "species_10514111", "catalyst" ] ], "additional_components": [ "Q21381", "WBGene00043980", "Q9GYQ1", "WBGene00043980", "Q21382", "WBGene00043980", "Q9NEI8", "WBGene00043980", "Q21385", "WBGene00043980", "Q5WRR9", "WBGene00043980" ] }, "reaction_10514195": { "compartment": "compartment_876", "id": "reaction_10514195", "reactome": "R-CEL-198870", "name": "SLC23A1,2 cotransports AscH-, 2Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_198836", "species_74113" ], "products": [ "species_83910", "species_198816" ], "modifiers": [ [ "species_10514192", "catalyst" ] ], "additional_components": [ "O18061", "WBGene00021994", "D6RYE3", "WBGene00021994", "Q18771", "WBGene00021994", "G8JZM6", "WBGene00021994", "Q9TYX7", "WBGene00021994", "O18057", "WBGene00021994" ] }, "reaction_10514075": { "compartment": "compartment_70101", "id": "reaction_10514075", "reactome": "R-CEL-198813", "name": "GSTO dimers reduce DeHA to AscH-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29450", "species_198827" ], "products": [ "species_198816", "species_111745" ], "modifiers": [ [ "species_10514072", "catalyst" ] ], "additional_components": [ "P34277", "WBGene00015337", "D7SFI3", "WBGene00043097", "P34345", "WBGene00016204", "O17234", "WBGene00019636", "O45352", "WBGene00001792" ] }, "reaction_10514141": { "compartment": "compartment_70101", "id": "reaction_10514141", "reactome": "R-CEL-198824", "name": "CYB5R3:FAD reduces CYB5A:ferriheme to CYB5A:heme", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_73473", "species_10514128" ], "products": [ "species_10514130", "species_29360" ], "modifiers": [ [ "species_10514138", "catalyst" ] ], "additional_components": [ "CHEBI:36144", "O01816", "WBGene00020931", "Q93315", "WBGene00007848", "species_71185", "O01816", "WBGene00020931", "Q93315", "WBGene00007848", "O16521", "WBGene00020268", "species_113596" ] }, "reaction_10529632": { "compartment": "compartment_70101", "id": "reaction_10529632", "reactome": "R-CEL-964958", "name": "2xPDXK:2xZn2+ phosphorylates PXA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_964945", "species_113592" ], "products": [ "species_29370", "species_965146" ], "modifiers": [ [ "species_10529629", "catalyst" ] ], "additional_components": [ "species_216785", "O01824", "WBGene00019008" ] }, "reaction_10529648": { "compartment": "compartment_70101", "id": "reaction_10529648", "reactome": "R-CEL-965079", "name": "2xPNPO:2xFMN oxidizes PXAP to PXLP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_29368", "species_965146" ], "products": [ "species_29390", "species_31633", "species_29408" ], "modifiers": [ [ "species_10529643", "catalyst" ] ], "additional_components": [ "species_73524", "Q20939", "WBGene00018996" ] }, "reaction_10529634": { "compartment": "compartment_70101", "id": "reaction_10529634", "reactome": "R-CEL-964962", "name": "2xPDKX:2xZn2+ phosphorylates PDX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_965053" ], "products": [ "species_29370", "species_964952" ], "modifiers": [ [ "species_10529629", "catalyst" ] ], "additional_components": [ "species_216785", "O01824", "WBGene00019008" ] }, "reaction_10529636": { "compartment": "compartment_70101", "id": "reaction_10529636", "reactome": "R-CEL-964970", "name": "2xPDXK:2xZn2+ phosphorylates PXL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_965131" ], "products": [ "species_29390", "species_29370" ], "modifiers": [ [ "species_10529629", "catalyst" ] ], "additional_components": [ "species_216785", "O01824", "WBGene00019008" ] }, "reaction_10546502": { "compartment": "compartment_70101", "id": "reaction_10546502", "reactome": "R-CEL-3204311", "name": "AOX1 oxidises PXL to PDXate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_29368", "species_965131" ], "products": [ "species_3204324", "species_29408" ], "modifiers": [ [ "species_10546499", "catalyst" ] ], "additional_components": [ "CHEBI:33722", "CHEBI:44074", "species_113596", "O17892", "WBGene00010083", "O61198", "WBGene00017487", "Q960A1", "WBGene00015057" ] }, "reaction_10529646": { "compartment": "compartment_70101", "id": "reaction_10529646", "reactome": "R-CEL-965019", "name": "2xPNPO:2xFMN oxidizes PDXP to PXLP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_964952" ], "products": [ "species_29390", "species_29408" ], "modifiers": [ [ "species_10529643", "catalyst" ] ], "additional_components": [ "species_73524", "Q20939", "WBGene00018996" ] }, "reaction_10513776": { "compartment": "compartment_70101", "id": "reaction_10513776", "reactome": "R-CEL-197235", "name": "NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_197220" ], "products": [ "species_197256", "species_1132084" ], "modifiers": [ [ "species_10513773", "catalyst" ] ], "additional_components": [ "species_114632", "P91851", "WBGene00009176", "Q9XXM2", "WBGene00012295" ] }, "reaction_10514608": { "compartment": "compartment_5460", "id": "reaction_10514608", "reactome": "R-CEL-200474", "name": "NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8938083", "species_113593" ], "products": [ "species_8938078", "species_8938090" ], "modifiers": [ [ "species_10514605", "catalyst" ] ], "additional_components": [ "species_114632", "P91851", "WBGene00009176", "Q9XXM2", "WBGene00012295" ] }, "reaction_10523473": { "compartment": "compartment_876", "id": "reaction_10523473", "reactome": "R-CEL-429749", "name": "SLC5A8 transports monocarboxylates from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_429739", "species_74113" ], "products": [ "species_83910", "species_429748" ], "modifiers": [ [ "species_10523470", "catalyst" ] ], "additional_components": [ "species_113557", "species_29708", "species_8869604", "CHEBI:30772", "species_427486", "CHEBI:30768", "CHEBI:30772", "species_113557", "species_427486", "species_29708", "CHEBI:30768", "species_197230", "WBGene00018716" ] }, "reaction_10563652": { "compartment": "compartment_17951", "id": "reaction_10563652", "reactome": "R-CEL-6809287", "name": "NUDT12 hydrolyses NADH to NMNH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_141343", "species_192305", "species_389620" ], "products": [ "species_6809289", "species_193465" ], "modifiers": [ [ "species_10563649", "catalyst" ] ], "additional_components": [ "WBGene00003586" ] }, "reaction_10563127": { "compartment": "compartment_5460", "id": "reaction_10563127", "reactome": "R-CEL-6806967", "name": "CARKD dehydrates S-NAD(P)HX to NADPH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113593", "species_6807477" ], "products": [ "species_113548", "species_113581", "species_113529", "species_113600" ], "modifiers": [ [ "species_10563124", "catalyst" ] ], "additional_components": [ "WBGene00011298" ] }, "reaction_10566729": { "compartment": "compartment_876", "id": "reaction_10566729", "reactome": "R-CEL-8869603", "name": "SLC22A13 transports NCA from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8869604" ], "products": [ "species_197230" ], "modifiers": [ [ "species_10566726", "catalyst" ] ], "additional_components": [ "WBGene00020701" ] }, "reaction_10551672": { "compartment": "compartment_70101", "id": "reaction_10551672", "reactome": "R-CEL-5359451", "name": "NNMT transfers CH3 from SAM to NAM to form MNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_197277", "species_71284" ], "products": [ "species_549282", "species_71285" ], "modifiers": [ [ "species_10511828", "catalyst" ] ], "additional_components": [ "WBGene00015124" ] }, "reaction_10563119": { "compartment": "compartment_5460", "id": "reaction_10563119", "reactome": "R-CEL-6806966", "name": "APOA1BP dimer epimerises R-NAD(P)HX to S-NAD(P)HX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6807473" ], "products": [ "species_6807477" ], "modifiers": [ [ "species_10563116", "catalyst" ] ], "additional_components": [ "Q9XW15", "WBGene00012476" ] }, "reaction_10513759": { "compartment": "compartment_70101", "id": "reaction_10513759", "reactome": "R-CEL-197186", "name": "NAPRT1 dimer transfers PRIB to NCA to form NAMN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73566", "species_197230", "species_70106" ], "products": [ "species_111294", "species_197220" ], "modifiers": [ [ "species_10513756", "catalyst" ], [ "species_29926", "catalyst" ] ], "additional_components": [ "Q95XX1", "WBGene00021882" ] }, "reaction_10568517": { "compartment": "compartment_70101", "id": "reaction_10568517", "reactome": "R-CEL-8939959", "name": "NMNAT2 transfers an adenylyl group from ATP to NMN to yield NAD+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8869353", "species_113592" ], "products": [ "species_1132084", "species_29360" ], "modifiers": [ [ "species_10513773", "catalyst" ] ], "additional_components": [ "species_114632", "P91851", "WBGene00009176", "Q9XXM2", "WBGene00012295" ] }, "reaction_10514615": { "compartment": "compartment_7660", "id": "reaction_10514615", "reactome": "R-CEL-200512", "name": "NMNAT1 transfers an adenylyl group from ATP to NAMN to yield NAAD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200492", "species_29358" ], "products": [ "species_8878981", "species_200499" ], "modifiers": [ [ "species_10514612", "catalyst" ] ], "additional_components": [ "P91851", "WBGene00009176", "species_216785" ] }, "reaction_10569958": { "compartment": "compartment_5460", "id": "reaction_10569958", "reactome": "R-CEL-8955030", "name": "NADK2 dimer phosphorylates NAD+ to NADP+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113593", "species_113526" ], "products": [ "species_113581", "species_113563", "species_113529" ], "modifiers": [ [ "species_10569955", "catalyst" ] ], "additional_components": [ "Q9XXI5", "WBGene00012463" ] }, "reaction_10513786": { "compartment": "compartment_70101", "id": "reaction_10513786", "reactome": "R-CEL-197271", "name": "NADSYN1 hexamer amidates NAAD to NAD+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_197256", "species_113592", "species_29472" ], "products": [ "species_111294", "species_29404", "species_76577", "species_29360" ], "modifiers": [ [ "species_10513783", "catalyst" ] ], "additional_components": [ "Q9XXK6", "WBGene00007698" ] }, "reaction_10513714": { "compartment": "compartment_70101", "id": "reaction_10513714", "reactome": "R-CEL-196840", "name": "3xPPCDC:3FMN decarboxylates PPC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_196834" ], "products": [ "species_196767", "species_113528" ], "modifiers": [ [ "species_10513711", "catalyst" ] ], "additional_components": [ "species_73524", "P91988", "WBGene00009138" ] }, "reaction_10513683": { "compartment": "compartment_70101", "id": "reaction_10513683", "reactome": "R-CEL-196753", "name": "2xPPCS ligates PPanK with Cys", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111707", "species_113592", "species_196786" ], "products": [ "species_111294", "species_196834", "species_76577" ], "modifiers": [ [ "species_10513680", "catalyst" ] ], "additional_components": [ "Q9BL36", "WBGene00022171" ] }, "reaction_10513704": { "compartment": "compartment_70101", "id": "reaction_10513704", "reactome": "R-CEL-196773", "name": "COASY phosphorylates DP-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_196778" ], "products": [ "species_29370", "species_76194" ], "modifiers": [ [ "species_10513688", "catalyst" ] ], "additional_components": [ "WBGene00022031" ] }, "reaction_10513691": { "compartment": "compartment_70101", "id": "reaction_10513691", "reactome": "R-CEL-196754", "name": "COASY transfers an adenylyl group from ATP to PPANT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_196767", "species_113592" ], "products": [ "species_111294", "species_196778" ], "modifiers": [ [ "species_10513688", "catalyst" ] ], "additional_components": [ "WBGene00022031" ] }, "reaction_10514238": { "compartment": "compartment_70101", "id": "reaction_10514238", "reactome": "R-CEL-199202", "name": "Phosphopantetheine conjugation of the ACP domain of FAS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10514230", "species_76194" ], "products": [ "species_10507450", "species_158466" ], "modifiers": [ [ "species_10514235", "catalyst" ] ], "additional_components": [ "WBGene00009342", "WBGene00009342", "WBGene00012142" ] }, "reaction_10567381": { "compartment": "compartment_17927", "id": "reaction_10567381", "reactome": "R-CEL-8875838", "name": "SLC25A19 transports ThDP from cytosol to mitochondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29480" ], "products": [ "species_8878387" ], "modifiers": [ [ "species_10567378", "catalyst" ] ], "additional_components": [ "WBGene00016588" ] }, "reaction_10513701": { "compartment": "compartment_70101", "id": "reaction_10513701", "reactome": "R-CEL-196761", "name": "2xTPK1:Mg2+ phosphorylates THMN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_196934" ], "products": [ "species_29480", "species_76577" ], "modifiers": [ [ "species_10513698", "catalyst" ] ], "additional_components": [ "P30636", "WBGene00014027", "species_114632" ] }, "reaction_10514362": { "compartment": "compartment_876", "id": "reaction_10514362", "reactome": "R-CEL-199626", "name": "SLC19A2/3 transport extracellular THMN to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_199622" ], "products": [ "species_196934" ], "modifiers": [ [ "species_10514359", "catalyst" ] ], "additional_components": [ "Q22931", "WBGene00044738", "O45166", "WBGene00018138", "Q17766", "WBGene00007388" ] }, "reaction_10546096": { "compartment": "compartment_70101", "id": "reaction_10546096", "reactome": "R-CEL-2993799", "name": "HLCS biotinylates 6xMCCC1:6xMCCC2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546090", "species_113592", "species_199207" ], "products": [ "species_111294", "species_10546094", "species_76577" ], "modifiers": [ [ "species_10546065", "catalyst" ] ], "additional_components": [ "O45430", "WBGene00009319", "P34385", "WBGene00303021", "P34385", "WBGene00303021", "O45430", "WBGene00009319", "WBGene00000259" ] }, "reaction_10546068": { "compartment": "compartment_70101", "id": "reaction_10546068", "reactome": "R-CEL-2993447", "name": "HLCS biotinylates 6x(PCCA:PCCB)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10546054", "species_199207" ], "products": [ "species_111294", "species_10546060", "species_76577" ], "modifiers": [ [ "species_10546065", "catalyst" ] ], "additional_components": [ "Q20676", "WBGene00018701", "Q19842", "WBGene00017864", "Q20676", "WBGene00018701", "Q19842", "WBGene00017864", "WBGene00000259" ] }, "reaction_10546117": { "compartment": "compartment_70101", "id": "reaction_10546117", "reactome": "R-CEL-2993814", "name": "HLCS biotinylates ACACA:Mn2+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_199207", "species_10546115" ], "products": [ "species_111294", "species_10507413", "species_76577" ], "modifiers": [ [ "species_10546065", "catalyst" ] ], "additional_components": [ "H2L0M0", "WBGene00004076", "Q9XUC3", "WBGene00012131", "species_266099", "Q9XUC3", "WBGene00012131", "H2L0M0", "WBGene00004076", "species_266099", "WBGene00000259" ] }, "reaction_10549065": { "compartment": "compartment_70101", "id": "reaction_10549065", "reactome": "R-CEL-4167511", "name": "HLCS biotinylates ACACB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10549063", "species_199207" ], "products": [ "species_111294", "species_10514575", "species_76577" ], "modifiers": [ [ "species_10546065", "catalyst" ] ], "additional_components": [ "H2L0M0", "WBGene00004076", "species_266099", "species_266099", "H2L0M0", "WBGene00004076", "WBGene00000259" ] }, "reaction_10546107": { "compartment": "compartment_70101", "id": "reaction_10546107", "reactome": "R-CEL-2993802", "name": "HLCS biotinylates PC:Mn2+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_199207", "species_10546100" ], "products": [ "species_111294", "species_10546105", "species_76577" ], "modifiers": [ [ "species_10546065", "catalyst" ] ], "additional_components": [ "O17732", "WBGene00004258", "species_266099", "O17732", "WBGene00004258", "species_266099", "WBGene00000259" ] }, "reaction_10547436": { "compartment": "compartment_70101", "id": "reaction_10547436", "reactome": "R-CEL-3323111", "name": "Cytoslic carboxylases translocate to mitochondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10547434" ], "products": [ "species_10546283" ], "modifiers": [], "additional_components": [ "O17732", "WBGene00004258", "species_266099", "Q20676", "WBGene00018701", "Q19842", "WBGene00017864", "P34385", "WBGene00303021", "O45430", "WBGene00009319", "species_266099", "O17732", "WBGene00004258", "Q19842", "WBGene00017864", "Q20676", "WBGene00018701", "P34385", "WBGene00303021", "O45430", "WBGene00009319" ] }, "reaction_10529569": { "compartment": "compartment_70101", "id": "reaction_10529569", "reactome": "R-CEL-947535", "name": "Cyclisation of GTP to precursor Z", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_29356", "species_71284" ], "products": [ "species_111294", "species_947537", "species_947703", "species_174390" ], "modifiers": [ [ "species_10529566", "catalyst" ] ], "additional_components": [ "CHEBI:33722", "Q20624", "WBGene00009885" ] }, "reaction_10529522": { "compartment": "compartment_70101", "id": "reaction_10529522", "reactome": "R-CEL-947499", "name": "Exchange of oxygen with sulfur in MoCo", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_947539", "species_111707" ], "products": [ "species_947575", "species_29432" ], "modifiers": [ [ "species_10529519", "catalyst" ] ], "additional_components": [ "WBGene00010983" ] }, "reaction_10529557": { "compartment": "compartment_70101", "id": "reaction_10529557", "reactome": "R-CEL-947531", "name": "Molybdenum ion transfer onto molybdopterin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_947561", "species_947496" ], "products": [ "species_111294", "species_947539", "species_76577" ], "modifiers": [ [ "species_10529554", "catalyst" ] ], "additional_components": [ "species_114632", "G5EGH2", "WBGene00003384" ] }, "reaction_10529545": { "compartment": "compartment_70101", "id": "reaction_10529545", "reactome": "R-CEL-947514", "name": "PXLP-K258-NFS1 transfers sulfur from cysteine onto MOCS3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111707", "species_10529529" ], "products": [ "species_10529534", "species_29432" ], "modifiers": [ [ "species_10529542", "catalyst" ] ], "additional_components": [ "species_216785", "O44510", "WBGene00018357", "species_216785", "O44510", "WBGene00018357", "O61741", "WBGene00015021" ] }, "reaction_10513732": { "compartment": "compartment_70101", "id": "reaction_10513732", "reactome": "R-CEL-196950", "name": "2xTRAP hydrolyzes FMN to RIB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_73524" ], "products": [ "species_29372", "species_196931" ], "modifiers": [ [ "species_10513729", "catalyst" ] ], "additional_components": [ "O01320", "WBGene00008531" ] }, "reaction_10513749": { "compartment": "compartment_70101", "id": "reaction_10513749", "reactome": "R-CEL-196955", "name": "2xENPP1 hydrolyzes FAD to FMN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_29386" ], "products": [ "species_73524", "species_76577" ], "modifiers": [ [ "species_10513746", "catalyst" ] ], "additional_components": [ "P90754", "WBGene00007755", "P90755", "WBGene00007755" ] }, "reaction_10513722": { "compartment": "compartment_70101", "id": "reaction_10513722", "reactome": "R-CEL-196929", "name": "FLAD1 phosphorylates FMN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_73524" ], "products": [ "species_111294", "species_29386" ], "modifiers": [ [ "species_10513719", "catalyst" ] ], "additional_components": [ "WBGene00011271" ] }, "reaction_10546475": { "compartment": "compartment_70101", "id": "reaction_10546475", "reactome": "R-CEL-3165230", "name": "SLC52A1,2,3 transport RIB from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_3165253" ], "products": [ "species_196931" ], "modifiers": [ [ "species_10546472", "catalyst" ], [ "species_73524", "inhibitor" ], [ "species_29386", "inhibitor" ] ], "additional_components": [ "G4SDH4", "WBGene00021626", "Q3LFN0", "WBGene00044637" ] }, "reaction_10546433": { "compartment": "compartment_70101", "id": "reaction_10546433", "reactome": "R-CEL-3149519", "name": "MMACHC decyanates CNCbl", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_3149505", "species_10546288" ], "products": [ "species_29366", "species_1130611", "species_10546290" ], "modifiers": [ [ "species_10546288", "catalyst" ] ], "additional_components": [ "WBGene00022766", "Q7Z144", "WBGene00022766", "species_3149479", "WBGene00022766" ] }, "reaction_10546436": { "compartment": "compartment_70101", "id": "reaction_10546436", "reactome": "R-CEL-3149539", "name": "MTR transfers CH3 group from MTHF to cob(I)alamin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200665", "species_10511764" ], "products": [ "species_111355", "species_10511760" ], "modifiers": [ [ "species_10511764", "catalyst" ] ], "additional_components": [ "species_216785", "species_3159260", "Q09582", "WBGene00010988", "species_73524", "Q17574", "WBGene00006510", "species_113596", "species_73524", "Q17574", "WBGene00006510", "species_113596", "species_216785", "CHEBI:28115", "Q09582", "WBGene00010988", "species_216785", "species_3159260", "Q09582", "WBGene00010988", "species_73524", "Q17574", "WBGene00006510", "species_113596" ] }, "reaction_10550725": { "compartment": "compartment_70101", "id": "reaction_10550725", "reactome": "R-CEL-5223313", "name": "ABCD4 may transport Cbl from lysosomal lumen to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_3000239" ], "products": [ "species_29372", "species_3000241", "species_29370" ], "modifiers": [ [ "species_10550722", "catalyst" ] ], "additional_components": [ "WBGene00004060" ] }, "reaction_10546438": { "compartment": "compartment_70101", "id": "reaction_10546438", "reactome": "R-CEL-3149563", "name": "MMADHC targets transport of cytosolic cob(II)alamin to mitochondria", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546415" ], "products": [ "species_3149564", "species_10546417" ], "modifiers": [], "additional_components": [ "Q7Z144", "WBGene00022766", "species_3149479", "Q9XWC9", "WBGene00013577", "Q7Z144", "WBGene00022766", "Q9XWC9", "WBGene00013577" ] }, "reaction_10546504": { "compartment": "compartment_70101", "id": "reaction_10546504", "reactome": "R-CEL-3204318", "name": "cob(II)alamin binds to MTRR:MTR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546425", "species_3149479" ], "products": [ "species_10546427" ], "modifiers": [], "additional_components": [ "species_73524", "Q17574", "WBGene00006510", "species_113596", "species_216785", "Q09582", "WBGene00010988", "species_3149479", "species_73524", "Q17574", "WBGene00006510", "species_113596", "species_216785", "Q09582", "WBGene00010988" ] }, "reaction_10546448": { "compartment": "compartment_5460", "id": "reaction_10546448", "reactome": "R-CEL-3159253", "name": "MMAB transfers adenosyl group from ATP to cob(I)alamin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_3159260", "species_113593" ], "products": [ "species_3159274", "species_3159297" ], "modifiers": [ [ "species_10546445", "catalyst" ] ], "additional_components": [ "Q18218", "WBGene00016144" ] }, "reaction_10546450": { "compartment": "compartment_5460", "id": "reaction_10546450", "reactome": "R-CEL-3159259", "name": "MMAA:MUT binds AdoCbl", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10503659", "species_3159297" ], "products": [ "species_10503661" ], "modifiers": [], "additional_components": [ "Q22111", "WBGene00020169", "Q23381", "WBGene00014202", "species_3159297", "Q22111", "WBGene00020169", "Q23381", "WBGene00014202" ] }, "reaction_10503666": { "compartment": "compartment_5460", "id": "reaction_10503666", "reactome": "R-CEL-71010", "name": "MUT isomerises L-MM-CoA to SUCC-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71009" ], "products": [ "species_70958" ], "modifiers": [ [ "species_10503661", "catalyst" ] ], "additional_components": [ "species_3159297", "Q22111", "WBGene00020169", "Q23381", "WBGene00014202" ] }, "reaction_10546419": { "compartment": "compartment_70101", "id": "reaction_10546419", "reactome": "R-CEL-3149492", "name": "cob(II)alamin dissociates from MMACHC:MMADHC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546415" ], "products": [ "species_3149479", "species_10546417" ], "modifiers": [], "additional_components": [ "Q7Z144", "WBGene00022766", "species_3149479", "Q9XWC9", "WBGene00013577", "Q7Z144", "WBGene00022766", "Q9XWC9", "WBGene00013577" ] }, "reaction_10546293": { "compartment": "compartment_70101", "id": "reaction_10546293", "reactome": "R-CEL-3095889", "name": "MMACHC reduces Cbl", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_3000241", "species_70106", "species_29364", "species_10546288" ], "products": [ "species_29366", "species_10546290" ], "modifiers": [ [ "species_10546288", "catalyst" ] ], "additional_components": [ "WBGene00022766", "Q7Z144", "WBGene00022766", "species_3149479", "WBGene00022766" ] }, "reaction_10546421": { "compartment": "compartment_70101", "id": "reaction_10546421", "reactome": "R-CEL-3149494", "name": "MMACHC:cob(II)alamin binds MMADHC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546413", "species_10546290" ], "products": [ "species_10546415" ], "modifiers": [], "additional_components": [ "WBGene00013577", "Q7Z144", "WBGene00022766", "species_3149479", "Q7Z144", "WBGene00022766", "species_3149479", "Q9XWC9", "WBGene00013577" ] }, "reaction_10546296": { "compartment": "compartment_70101", "id": "reaction_10546296", "reactome": "R-CEL-3095901", "name": "ABCC1 transports cytosolic Cbl to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_3000241", "species_113592" ], "products": [ "species_29372", "species_29370", "species_3000125" ], "modifiers": [ [ "species_10517853", "catalyst" ] ], "additional_components": [ "WBGene00003407" ] }, "reaction_10546430": { "compartment": "compartment_70101", "id": "reaction_10546430", "reactome": "R-CEL-3149518", "name": "MTRR reduces cob(II)alamin to meCbl", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_10546427", "species_71284", "species_29364" ], "products": [ "species_29366", "species_71285", "species_10511760" ], "modifiers": [ [ "species_10546427", "catalyst" ] ], "additional_components": [ "species_3149479", "species_73524", "Q17574", "WBGene00006510", "species_113596", "species_216785", "Q09582", "WBGene00010988", "species_73524", "Q17574", "WBGene00006510", "species_113596", "species_216785", "CHEBI:28115", "Q09582", "WBGene00010988", "species_3149479", "species_73524", "Q17574", "WBGene00006510", "species_113596", "species_216785", "Q09582", "WBGene00010988" ] }, "reaction_10535154": { "compartment": "compartment_70101", "id": "reaction_10535154", "reactome": "R-CEL-1497796", "name": "BH2 binding can lead to eNOS uncoupling", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10515166", "species_1497857" ], "products": [ "species_29870", "species_10535152" ], "modifiers": [], "additional_components": [ "Q9XTG7", "WBGene00000103", "G4S4W1", "WBGene00016980", "Q17941", "WBGene00000102", "species_74016", "Q11083", "WBGene00020378", "P04630", "WBGene00000285", "G5EF37", "WBGene00003934", "A0A2C9C3L3", "WBGene00020378", "Q18136", "WBGene00006861", "Q09665", "WBGene00006583", "O02159", "WBGene00020378", "G5EDZ8", "WBGene00000288", "Q94288", "WBGene00000287", "Q09980", "WBGene00017394", "O16305", "WBGene00000552", "G5EEG0", "WBGene00000286", "Q18688", "WBGene00000915", "species_71185", "species_216785", "species_73524", "species_113596", "species_29870", "Q9XTG7", "WBGene00000103", "G4S4W1", "WBGene00016980", "Q17941", "WBGene00000102", "species_74016", "Q11083", "WBGene00020378", "P04630", "WBGene00000285", "G5EF37", "WBGene00003934", "A0A2C9C3L3", "WBGene00020378", "Q18136", "WBGene00006861", "Q09665", "WBGene00006583", "O02159", "WBGene00020378", "G5EDZ8", "WBGene00000288", "Q94288", "WBGene00000287", "Q09980", "WBGene00017394", "O16305", "WBGene00000552", "G5EEG0", "WBGene00000286", "Q18688", "WBGene00000915", "species_1497857", "species_71185", "species_216785", "species_73524", "species_113596", "species_29870" ] }, "reaction_10534357": { "compartment": "compartment_70101", "id": "reaction_10534357", "reactome": "R-CEL-1474184", "name": "DHNTP is dephosphorylated by PTPS to PTHP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1474124" ], "products": [ "species_1475054", "species_1474179" ], "modifiers": [ [ "species_10534354", "catalyst" ] ], "additional_components": [ "O02058", "WBGene00015010", "species_216785" ] }, "reaction_10534343": { "compartment": "compartment_70101", "id": "reaction_10534343", "reactome": "R-CEL-1474146", "name": "GCH1 reduces GTP to dihydroneopterin triphosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_29356" ], "products": [ "species_1474124", "species_29460" ], "modifiers": [ [ "species_10534331", "catalyst" ], [ "species_29502", "catalyst" ], [ "species_29870", "inhibitor" ], [ "species_10534341", "inhibitor" ] ], "additional_components": [ "Q19980", "WBGene00000298", "D6RYD9", "WBGene00044736", "Q19980", "WBGene00000298" ] }, "reaction_10534712": { "compartment": "compartment_70101", "id": "reaction_10534712", "reactome": "R-CEL-1475422", "name": "PTPS is phosphorylated by cGMP-dependant protein kinase II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10534700", "species_113592" ], "products": [ "species_29370", "species_10534354" ], "modifiers": [ [ "species_10534709", "catalyst" ] ], "additional_components": [ "O02058", "WBGene00015010", "O02058", "WBGene00015010", "species_216785", "H2KYN2", "WBGene00015650", "O76360", "WBGene00001173" ] }, "reaction_10534346": { "compartment": "compartment_70101", "id": "reaction_10534346", "reactome": "R-CEL-1474158", "name": "GCHFR binds to GCH1 and negatively regulates its activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10534331", "species_10534339" ], "products": [ "species_10534341" ], "modifiers": [], "additional_components": [ "Q19980", "WBGene00000298", "D6RYD9", "WBGene00044736", "D6RYD9", "WBGene00044736", "Q19980", "WBGene00000298" ] }, "reaction_10520593": { "compartment": "compartment_70101", "id": "reaction_10520593", "reactome": "R-CEL-389540", "name": "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_389545", "species_29366" ], "products": [ "species_29406", "species_70106", "species_113528", "species_29364" ], "modifiers": [ [ "species_10520590", "catalyst" ] ], "additional_components": [ "H9G2T4", "WBGene00010317" ] }, "reaction_10552560": { "compartment": "compartment_70101", "id": "reaction_10552560", "reactome": "R-CEL-5578910", "name": "KCNK dimers transport K+ from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10552557", "catalyst" ] ], "additional_components": [ "O17185", "WBGene00006318", "Q10937", "WBGene00015137", "Q9NEV3", "WBGene00006696", "G5ECW6", "WBGene00006673" ] }, "reaction_10572199": { "compartment": "compartment_7660", "id": "reaction_10572199", "reactome": "R-CEL-9617927", "name": "FOXO4 binds ATXN3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10556072", "species_10514278" ], "products": [ "species_10572197" ], "modifiers": [], "additional_components": [ "WBGene00006446", "WBGene00000912", "O16850", "WBGene00000912", "O17850", "WBGene00006446" ] }, "reaction_10572203": { "compartment": "compartment_7660", "id": "reaction_10572203", "reactome": "R-CEL-9617996", "name": "FOXO1,FOXO3,FOXO4 bind p-2S-SMAD2/3:SMAD4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10511518", "species_10514274" ], "products": [ "species_10572201" ], "modifiers": [], "additional_components": [ "P45897", "WBGene00004858", "Q21733", "WBGene00000904", "WBGene00000912", "O16850", "WBGene00000912", "P45897", "WBGene00004858", "Q21733", "WBGene00000904" ] }, "reaction_10572288": { "compartment": "compartment_7660", "id": "reaction_10572288", "reactome": "R-CEL-9626928", "name": "CREBBP binds FOXO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10532226", "species_10514274" ], "products": [ "species_10572286" ], "modifiers": [], "additional_components": [ "WBGene00000366", "WBGene00000912", "O16850", "WBGene00000912", "P34545", "WBGene00000366" ] }, "reaction_10572248": { "compartment": "compartment_7660", "id": "reaction_10572248", "reactome": "R-CEL-9620515", "name": "KAT2B,EP300 acetylate FOXO3 under oxidative stress", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113560", "species_10514276" ], "products": [ "species_2485002", "species_10572243" ], "modifiers": [ [ "species_10572245", "catalyst" ], [ "species_3785707", "catalyst" ] ], "additional_components": [ "WBGene00000912", "WBGene00000912", "Q9N3S7", "WBGene00021636" ] }, "reaction_10572251": { "compartment": "compartment_7660", "id": "reaction_10572251", "reactome": "R-CEL-9620532", "name": "SIRT1,SIRT3 deacetylate FOXO3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_427523", "species_10572243" ], "products": [ "species_427497", "species_427498", "species_10514276" ], "modifiers": [ [ "species_10522802", "catalyst" ] ], "additional_components": [ "WBGene00000912", "WBGene00000912", "WBGene00004800" ] }, "reaction_10572161": { "compartment": "compartment_70101", "id": "reaction_10572161", "reactome": "R-CEL-9614423", "name": "14-3-3 proteins bind AKT-phosphorylated FOXO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10572157", "species_10516880" ], "products": [ "species_10572159" ], "modifiers": [], "additional_components": [ "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "WBGene00000912", "O16850", "WBGene00000912", "P41932", "WBGene00003920", "Q20655", "WBGene00001502" ] }, "reaction_10572167": { "compartment": "compartment_70101", "id": "reaction_10572167", "reactome": "R-CEL-9614562", "name": "14-3-3 proteins bind AKT-phosphorylated FOXO3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10572151", "species_10572163" ], "products": [ "species_10572165" ], "modifiers": [], "additional_components": [ "WBGene00000912", "Q20655", "WBGene00001502", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "P41932", "WBGene00003920", "O16850", "WBGene00000912" ] }, "reaction_10572155": { "compartment": "compartment_7660", "id": "reaction_10572155", "reactome": "R-CEL-9614414", "name": "AKT-phosphorylated FOXO1,FOXO3,FOXO4 translocate to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10514285" ], "products": [ "species_10516880" ], "modifiers": [], "additional_components": [ "WBGene00000912", "WBGene00000912" ] }, "reaction_10572171": { "compartment": "compartment_70101", "id": "reaction_10572171", "reactome": "R-CEL-9614564", "name": "14-3-3 proteins bind AKT-phosphorylated FOXO4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10572153", "species_10507059" ], "products": [ "species_10572169" ], "modifiers": [], "additional_components": [ "WBGene00000912", "Q20655", "WBGene00001502", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "P41932", "WBGene00003920", "O16850", "WBGene00000912" ] }, "reaction_10569079": { "compartment": "compartment_7660", "id": "reaction_10569079", "reactome": "R-CEL-8951966", "name": "EP300 acetylates RUNX3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10569066", "species_113560" ], "products": [ "species_2485002", "species_10569076" ], "modifiers": [ [ "species_10569066", "catalyst" ], [ "species_10511431", "catalyst" ] ], "additional_components": [ "P34545", "WBGene00000366", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "G5EFQ5", "WBGene00004393", "Q95ZL9", "WBGene00000272", "P34545", "WBGene00000366", "P34545", "WBGene00000366", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "G5EBY8", "WBGene00006852", "G5EEL5", "WBGene00000936" ] }, "reaction_10569160": { "compartment": "compartment_7660", "id": "reaction_10569160", "reactome": "R-CEL-8952062", "name": "CCND1 recruits HDAC4 to RUNX3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10549372", "species_10569156" ], "products": [ "species_10569158" ], "modifiers": [], "additional_components": [ "WBGene00001837", "G5EFQ5", "WBGene00004393", "Q95ZL9", "WBGene00000272", "O76561", "WBGene00017423", "Q95Y80", "WBGene00022473", "A0A0K3AWB8", "F57C7.1d", "G5EFQ5", "WBGene00004393", "Q95ZL9", "WBGene00000272", "O76561", "WBGene00017423", "Q95Y80", "WBGene00022473", "A0A0K3AWB8", "F57C7.1d", "O17323", "WBGene00001837" ] }, "reaction_10569165": { "compartment": "compartment_7660", "id": "reaction_10569165", "reactome": "R-CEL-8952069", "name": "HDAC4 deacetylates RUNX3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10569158" ], "products": [ "species_10569098", "species_10569162", "species_427486" ], "modifiers": [ [ "species_10569158", "catalyst" ] ], "additional_components": [ "G5EFQ5", "WBGene00004393", "Q95ZL9", "WBGene00000272", "O76561", "WBGene00017423", "Q95Y80", "WBGene00022473", "A0A0K3AWB8", "F57C7.1d", "O17323", "WBGene00001837", "O76561", "WBGene00017423", "Q95Y80", "WBGene00022473", "A0A0K3AWB8", "F57C7.1d", "O17323", "WBGene00001837", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "G5EFQ5", "WBGene00004393", "Q95ZL9", "WBGene00000272", "O76561", "WBGene00017423", "Q95Y80", "WBGene00022473", "A0A0K3AWB8", "F57C7.1d", "O17323", "WBGene00001837" ] }, "reaction_10569068": { "compartment": "compartment_7660", "id": "reaction_10569068", "reactome": "R-CEL-8951951", "name": "RUNX3 binds EP300", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10566207", "species_10532228" ], "products": [ "species_10569066" ], "modifiers": [], "additional_components": [ "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "WBGene00000366", "P34545", "WBGene00000366", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393" ] }, "reaction_10569102": { "compartment": "compartment_7660", "id": "reaction_10569102", "reactome": "R-CEL-8951977", "name": "Acetylated RUNX3 binds to BRD2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10569098", "species_10569076" ], "products": [ "species_10569100" ], "modifiers": [ [ "species_10549046", "catalyst" ] ], "additional_components": [ "O76561", "WBGene00017423", "Q95Y80", "WBGene00022473", "A0A0K3AWB8", "F57C7.1d", "G5EFQ5", "WBGene00004393", "Q95ZL9", "WBGene00000272", "P34545", "WBGene00000366", "G5EFQ5", "WBGene00004393", "Q95ZL9", "WBGene00000272", "P34545", "WBGene00000366", "O76561", "WBGene00017423", "Q95Y80", "WBGene00022473", "A0A0K3AWB8", "F57C7.1d", "P22981", "WBGene00002335", "species_29438" ] }, "reaction_10570708": { "compartment": "compartment_7660", "id": "reaction_10570708", "reactome": "R-CEL-9008822", "name": "PPM1D dephosphorylates RUNX2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10570700" ], "products": [ "species_10567753", "species_113541" ], "modifiers": [ [ "species_10570705", "catalyst" ] ], "additional_components": [ "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "G5EFQ5", "WBGene00004393", "Q95ZL9", "WBGene00000272", "WBGene00021856" ] }, "reaction_10568512": { "compartment": "compartment_7660", "id": "reaction_10568512", "reactome": "R-CEL-8939706", "name": "SCF(SKP2) polyubiquitinates RUNX2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502318", "species_10568502" ], "products": [ "species_10568507", "species_10502340" ], "modifiers": [ [ "species_10568502", "catalyst" ] ], "additional_components": [ "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "G5EFQ5", "WBGene00004393", "Q23457", "WBGene00004320", "G5ECU1", "WBGene00004807", "Q17389", "WBGene00000836", "WBGene00004393", "Q23457", "WBGene00004320", "G5ECU1", "WBGene00004807", "Q17389", "WBGene00000836", "G5EFQ5", "WBGene00004393", "Q23457", "WBGene00004320", "G5ECU1", "WBGene00004807", "Q17389", "WBGene00000836" ] }, "reaction_10568514": { "compartment": "compartment_7660", "id": "reaction_10568514", "reactome": "R-CEL-8939801", "name": "26S proteasome degrades PolyUb-RUNX2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10568507" ], "products": [ "species_10502318" ], "modifiers": [ [ "species_10512606", "catalyst" ] ], "additional_components": [ "WBGene00004393", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "Q23237", "WBGene00003949", "P90868", "WBGene00003953", "Q9XUV0", "WBGene00003951", "Q966I8", "WBGene00003947", "O62102", "WBGene00003948", "O16368", "WBGene00004502", "Q18787", "WBGene00004501", "O76371", "WBGene00004505", "P46502", "WBGene00004503", "Q9XTT9", "WBGene00004506", "O17071", "WBGene00004504", "Q18115", "WBGene00004459", "Q20938", "WBGene00004462", "Q19324", "WBGene00004461", "Q22253", "WBGene00004465", "Q9GZH5", "WBGene00004458", "Q04908", "WBGene00004460", "O61742", "WBGene00004466", "O76577", "WBGene00004467", "Q20058", "WBGene00009445", "O44156", "WBGene00003927", "Q20585", "WBGene00004463", "Q27488", "WBGene00003923", "O61792", "WBGene00004464", "Q09583", "WBGene00003928", "Q23449", "WBGene00004468", "Q9N599", "WBGene00003924", "Q10920", "WBGene00016623", "Q95008", "WBGene00003926", "Q95PZ7", "WBGene00013435", "O17586", "WBGene00003922", "Q95005", "WBGene00003925", "P34286", "WBGene00003952", "P91477", "WBGene00003950" ] }, "reaction_10570789": { "compartment": "compartment_70101", "id": "reaction_10570789", "reactome": "R-CEL-9009308", "name": "STUB1 polyubiquitinates RUNX2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10570782", "species_10502375" ], "products": [ "species_10570784", "species_10530864" ], "modifiers": [ [ "species_10570782", "catalyst" ] ], "additional_components": [ "G5ECY6", "WBGene00000500", "G5EFQ5", "WBGene00004393", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "WBGene00004393", "WBGene00000500", "G5ECY6", "WBGene00000500", "G5EFQ5", "WBGene00004393" ] }, "reaction_10570791": { "compartment": "compartment_70101", "id": "reaction_10570791", "reactome": "R-CEL-9009309", "name": "RUNX2 binds STUB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10570778", "species_10530864" ], "products": [ "species_10570782" ], "modifiers": [], "additional_components": [ "WBGene00004393", "WBGene00000500", "G5ECY6", "WBGene00000500", "G5EFQ5", "WBGene00004393" ] }, "reaction_10568504": { "compartment": "compartment_7660", "id": "reaction_10568504", "reactome": "R-CEL-8939688", "name": "SCF(SKP2) complex binds RUNX2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502340", "species_10567747" ], "products": [ "species_10568502" ], "modifiers": [], "additional_components": [ "Q23457", "WBGene00004320", "G5ECU1", "WBGene00004807", "Q17389", "WBGene00000836", "WBGene00004393", "G5EFQ5", "WBGene00004393", "Q23457", "WBGene00004320", "G5ECU1", "WBGene00004807", "Q17389", "WBGene00000836" ] }, "reaction_10568390": { "compartment": "compartment_7660", "id": "reaction_10568390", "reactome": "R-CEL-8938356", "name": "RMB14 binds RUNX2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10568386", "species_10567747" ], "products": [ "species_10568388" ], "modifiers": [], "additional_components": [ "WBGene00004384", "WBGene00004393", "G5EFQ5", "WBGene00004393", "Q10667", "WBGene00004384" ] }, "reaction_10567757": { "compartment": "compartment_7660", "id": "reaction_10567757", "reactome": "R-CEL-8877941", "name": "RUNX2 binds SMAD1 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10567753", "species_10567751" ], "products": [ "species_10567755" ], "modifiers": [], "additional_components": [ "G5EFQ5", "WBGene00004393", "Q95ZL9", "WBGene00000272", "F5GUE5", "WBGene00000910", "P45896", "WBGene00004857", "Q02330", "WBGene00004856", "P45897", "WBGene00004858", "F5GUE5", "WBGene00000910", "P45896", "WBGene00004857", "Q02330", "WBGene00004856", "P45897", "WBGene00004858", "G5EFQ5", "WBGene00004393", "Q95ZL9", "WBGene00000272" ] }, "reaction_10570776": { "compartment": "compartment_7660", "id": "reaction_10570776", "reactome": "R-CEL-9009282", "name": "CDK1 phosphorylates RUNX2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10567753" ], "products": [ "species_113582", "species_10570692" ], "modifiers": [ [ "species_10511241", "catalyst" ] ], "additional_components": [ "G5EFQ5", "WBGene00004393", "Q95ZL9", "WBGene00000272", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "O45926", "WBGene00000866", "Q10653", "WBGene00000865", "Q9BLB5", "WBGene00000867", "P34556", "WBGene00000405" ] }, "reaction_10569938": { "compartment": "compartment_7660", "id": "reaction_10569938", "reactome": "R-CEL-8954110", "name": "E2F6:TFDP1:EPC1 binds the PRC2 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10569934", "species_10517100" ], "products": [ "species_10569936" ], "modifiers": [], "additional_components": [ "A5HWA8", "WBGene00001162", "Q22703", "WBGene00001061", "G5EC14", "WBGene00007030", "Q9GYS1", "WBGene00003224", "O17514", "WBGene00003220", "P90916", "WBGene00003036", "P90917", "WBGene00004312", "Q9GYS1", "WBGene00003224", "O17514", "WBGene00003220", "P90916", "WBGene00003036", "P90917", "WBGene00004312", "A5HWA8", "WBGene00001162", "Q22703", "WBGene00001061", "G5EC14", "WBGene00007030" ] }, "reaction_10569925": { "compartment": "compartment_7660", "id": "reaction_10569925", "reactome": "R-CEL-8954056", "name": "E2F6 binds TFDP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10532095", "species_10569808" ], "products": [ "species_10569923" ], "modifiers": [], "additional_components": [ "WBGene00001061", "WBGene00001162", "A5HWA8", "WBGene00001162", "Q22703", "WBGene00001061" ] }, "reaction_10569812": { "compartment": "compartment_7660", "id": "reaction_10569812", "reactome": "R-CEL-8953111", "name": "E2F6 binds TFDP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10532093", "species_10569808" ], "products": [ "species_10569810" ], "modifiers": [], "additional_components": [ "WBGene00001061", "WBGene00001162", "A5HWA8", "WBGene00001162", "Q22703", "WBGene00001061" ] }, "reaction_10569940": { "compartment": "compartment_7660", "id": "reaction_10569940", "reactome": "R-CEL-8954117", "name": "E2F6:TFDP1 binds EPC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10569932", "species_10569810" ], "products": [ "species_10569934" ], "modifiers": [], "additional_components": [ "WBGene00007030", "A5HWA8", "WBGene00001162", "Q22703", "WBGene00001061", "A5HWA8", "WBGene00001162", "Q22703", "WBGene00001061", "G5EC14", "WBGene00007030" ] }, "reaction_10570682": { "compartment": "compartment_7660", "id": "reaction_10570682", "reactome": "R-CEL-9007539", "name": "CHEK1 phosphorylates E2F6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10569808" ], "products": [ "species_113582", "species_10570680" ], "modifiers": [ [ "species_10502788", "catalyst" ] ], "additional_components": [ "WBGene00001162", "WBGene00001162", "WBGene00000498" ] }, "reaction_10569855": { "compartment": "compartment_7660", "id": "reaction_10569855", "reactome": "R-CEL-8953115", "name": "E2F6:TFDP1 binds to MGA:MAX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10569851", "species_10569810" ], "products": [ "species_10569853" ], "modifiers": [], "additional_components": [ "Q23622", "WBGene00006555", "Q8TA81", "WBGene00022695", "Q95PX3", "WBGene00006544", "Q9N2K7", "WBGene00006549", "Q9NA55", "WBGene00006559", "Q9NA56", "WBGene00006558", "Q9NAH2", "WBGene00006553", "Q9TZL0", "WBGene00006550", "Q9U2C9", "WBGene00006556", "Q9XVD5", "WBGene00006557", "O45291", "WBGene00006552", "O61764", "WBGene00006551", "Q20257", "WBGene00006547", "Q22289", "WBGene00006546", "Q22292", "WBGene00006545", "Q18711", "WBGene00003511", "A5HWA8", "WBGene00001162", "Q22703", "WBGene00001061", "A5HWA8", "WBGene00001162", "Q22703", "WBGene00001061", "Q23622", "WBGene00006555", "Q8TA81", "WBGene00022695", "Q95PX3", "WBGene00006544", "Q9N2K7", "WBGene00006549", "Q9NA55", "WBGene00006559", "Q9NA56", "WBGene00006558", "Q9NAH2", "WBGene00006553", "Q9TZL0", "WBGene00006550", "Q9U2C9", "WBGene00006556", "Q9XVD5", "WBGene00006557", "O45291", "WBGene00006552", "O61764", "WBGene00006551", "Q20257", "WBGene00006547", "Q22289", "WBGene00006546", "Q22292", "WBGene00006545", "Q18711", "WBGene00003511" ] }, "reaction_10565458": { "compartment": "compartment_7660", "id": "reaction_10565458", "reactome": "R-CEL-8853965", "name": "VENTX disrupts binding of CTNNB1 (beta-catenin) to TCF4 or LEF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10565454", "species_10565450" ], "products": [ "species_10514938", "species_10565456" ], "modifiers": [], "additional_components": [ "Q10666", "WBGene00004077", "O44326", "WBGene00001979", "WBGene00006380", "WBGene00001979", "Q10666", "WBGene00004077", "Q19937", "WBGene00006380" ] }, "reaction_10567123": { "compartment": "compartment_7660", "id": "reaction_10567123", "reactome": "R-CEL-8871265", "name": "YAP1 binds TEAD4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10532633", "species_10542193" ], "products": [ "species_10567121" ], "modifiers": [], "additional_components": [ "WBGene00008748", "WBGene00001208", "Q19849", "WBGene00001208", "Q19404", "WBGene00008748" ] }, "reaction_10542197": { "compartment": "compartment_7660", "id": "reaction_10542197", "reactome": "R-CEL-2032781", "name": "WWTR1 (TAZ) binds TEAD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10542174", "species_10542183" ], "products": [ "species_10542195" ], "modifiers": [], "additional_components": [ "WBGene00008748", "WBGene00001208", "Q19849", "WBGene00001208", "Q19404", "WBGene00008748" ] }, "reaction_10567127": { "compartment": "compartment_7660", "id": "reaction_10567127", "reactome": "R-CEL-8871266", "name": "YAP1 binds TEAD3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10542191", "species_10532633" ], "products": [ "species_10567125" ], "modifiers": [], "additional_components": [ "WBGene00001208", "WBGene00008748", "Q19404", "WBGene00008748", "Q19849", "WBGene00001208" ] }, "reaction_10542187": { "compartment": "compartment_7660", "id": "reaction_10542187", "reactome": "R-CEL-2032775", "name": "YAP1 binds TEAD1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10532633", "species_10542183" ], "products": [ "species_10542185" ], "modifiers": [], "additional_components": [ "WBGene00008748", "WBGene00001208", "Q19849", "WBGene00001208", "Q19404", "WBGene00008748" ] }, "reaction_10542283": { "compartment": "compartment_7660", "id": "reaction_10542283", "reactome": "R-CEL-2032794", "name": "WWTR1 (TAZ), TBX5, and PCAF form a complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10542174", "species_10542202", "species_10542279" ], "products": [ "species_10542281" ], "modifiers": [], "additional_components": [ "WBGene00008748", "WBGene00021636", "Q9U2C9", "WBGene00006556", "Q95PX3", "WBGene00006544", "O61764", "WBGene00006551", "Q9XVD5", "WBGene00006557", "Q9N2K7", "WBGene00006549", "Q20257", "WBGene00006547", "Q9NA55", "WBGene00006559", "Q22289", "WBGene00006546", "Q9NA56", "WBGene00006558", "Q22292", "WBGene00006545", "Q9NAH2", "WBGene00006553", "Q23622", "WBGene00006555", "Q9TZL0", "WBGene00006550", "Q8TA81", "WBGene00022695", "O45291", "WBGene00006552", "Q9U2C9", "WBGene00006556", "Q95PX3", "WBGene00006544", "O61764", "WBGene00006551", "Q9XVD5", "WBGene00006557", "Q9N2K7", "WBGene00006549", "Q20257", "WBGene00006547", "Q9NA55", "WBGene00006559", "Q22289", "WBGene00006546", "Q9NA56", "WBGene00006558", "Q22292", "WBGene00006545", "Q9NAH2", "WBGene00006553", "Q23622", "WBGene00006555", "Q9TZL0", "WBGene00006550", "Q8TA81", "WBGene00022695", "O45291", "WBGene00006552", "Q9N3S7", "WBGene00021636", "Q19404", "WBGene00008748" ] }, "reaction_10567119": { "compartment": "compartment_7660", "id": "reaction_10567119", "reactome": "R-CEL-8871260", "name": "YAP1 binds TEAD2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10542189", "species_10532633" ], "products": [ "species_10567117" ], "modifiers": [], "additional_components": [ "WBGene00001208", "WBGene00008748", "Q19404", "WBGene00008748", "Q19849", "WBGene00001208" ] }, "reaction_10567590": { "compartment": "compartment_7660", "id": "reaction_10567590", "reactome": "R-CEL-8877192", "name": "RUNX1 binds FOXP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10566201", "species_10567586" ], "products": [ "species_10567588" ], "modifiers": [], "additional_components": [ "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "WBGene00001439", "Q86MF0", "WBGene00001439", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393" ] }, "reaction_10568465": { "compartment": "compartment_7660", "id": "reaction_10568465", "reactome": "R-CEL-8938951", "name": "RUNX1 binds PAX5 (BSAP)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10568461", "species_10566201" ], "products": [ "species_10568463" ], "modifiers": [], "additional_components": [ "G5ED14", "WBGene00001204", "G5EDS1", "WBGene00006870", "Q21263", "WBGene00003938", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "G5ED14", "WBGene00001204", "G5EDS1", "WBGene00006870", "Q21263", "WBGene00003938" ] }, "reaction_10568444": { "compartment": "compartment_7660", "id": "reaction_10568444", "reactome": "R-CEL-8938930", "name": "RUNX1 binds ELF2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10568440", "species_10566201" ], "products": [ "species_10568442" ], "modifiers": [], "additional_components": [ "WBGene00016029", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "H2KYY1", "WBGene00016029" ] }, "reaction_10568259": { "compartment": "compartment_7660", "id": "reaction_10568259", "reactome": "R-CEL-8937022", "name": "PRMT6 arginine methylates H3K4me2-Nucleosome at the THBS1 gene promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10568254", "species_77087" ], "products": [ "species_77502", "species_10568256" ], "modifiers": [ [ "species_10568254", "catalyst" ] ], "additional_components": [ "A5JYW9", "WBGene00004117", "G5ECH0", "WBGene00001836", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "P62784", "WBGene00001875", "Q10453", "WBGene00001945", "K7ZUH9", "WBGene00001914", "A5JYW9", "WBGene00004117", "G5ECH0", "WBGene00001836", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "P62784", "WBGene00001875", "Q10453", "WBGene00001945", "K7ZUH9", "WBGene00001914", "A5JYW9", "WBGene00004117", "G5ECH0", "WBGene00001836", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "P62784", "WBGene00001875", "Q10453", "WBGene00001945", "K7ZUH9", "WBGene00001914" ] }, "reaction_10568275": { "compartment": "compartment_7660", "id": "reaction_10568275", "reactome": "R-CEL-8937113", "name": "PRMT6 arginine methylates H3K4me2-Nucleosome at the MIR27A gene promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10568270", "species_77087" ], "products": [ "species_77502", "species_10568272" ], "modifiers": [ [ "species_10568270", "catalyst" ] ], "additional_components": [ "A5JYW9", "WBGene00004117", "G5ECH0", "WBGene00001836", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "P62784", "WBGene00001875", "Q10453", "WBGene00001945", "K7ZUH9", "WBGene00001914", "A5JYW9", "WBGene00004117", "G5ECH0", "WBGene00001836", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "P62784", "WBGene00001875", "Q10453", "WBGene00001945", "K7ZUH9", "WBGene00001914", "A5JYW9", "WBGene00004117", "G5ECH0", "WBGene00001836", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "P62784", "WBGene00001875", "Q10453", "WBGene00001945", "K7ZUH9", "WBGene00001914" ] }, "reaction_10568130": { "compartment": "compartment_7660", "id": "reaction_10568130", "reactome": "R-CEL-8934735", "name": "PRMT1 arginine-methylates RUNX1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10568121" ], "products": [ "species_77502", "species_10568127" ], "modifiers": [ [ "species_10568121", "catalyst" ] ], "additional_components": [ "Q9U2X0", "WBGene00013766", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "Q95ZL9", "WBGene00000272", "Q9U2X0", "WBGene00013766", "G5EFQ5", "WBGene00004393", "Q9U2X0", "WBGene00013766", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393" ] }, "reaction_10568132": { "compartment": "compartment_7660", "id": "reaction_10568132", "reactome": "R-CEL-8934742", "name": "RUNX1 binds PRMT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10566201", "species_10546564" ], "products": [ "species_10568121" ], "modifiers": [], "additional_components": [ "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "WBGene00013766", "Q9U2X0", "WBGene00013766", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393" ] }, "reaction_10568196": { "compartment": "compartment_7660", "id": "reaction_10568196", "reactome": "R-CEL-8936481", "name": "Core MLL complex methylates H3K4Me2-Nucleosome at the ITGA2B gene promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10568187" ], "products": [ "species_77502", "species_10568193" ], "modifiers": [ [ "species_10568187", "catalyst" ] ], "additional_components": [ "Q10661", "WBGene00001088", "G5EFZ3", "WBGene00012458", "Q09309", "WBGene00017683", "Q18221", "WBGene00004782", "G5EGI1", "WBGene00011729", "Q17963", "WBGene00006474", "P34545", "WBGene00000366", "P28515", "WBGene00001249", "Q9N3S7", "WBGene00021636", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "Q9U2X0", "WBGene00013766", "P62784", "WBGene00001875", "Q10453", "WBGene00001945", "K7ZUH9", "WBGene00001914", "Q10661", "WBGene00001088", "G5EFZ3", "WBGene00012458", "Q09309", "WBGene00017683", "Q18221", "WBGene00004782", "G5EGI1", "WBGene00011729", "Q17963", "WBGene00006474", "P34545", "WBGene00000366", "P28515", "WBGene00001249", "Q9N3S7", "WBGene00021636", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "Q9U2X0", "WBGene00013766", "P62784", "WBGene00001875", "K7ZUH9", "WBGene00001914", "Q10453", "WBGene00001945", "Q10661", "WBGene00001088", "G5EFZ3", "WBGene00012458", "Q09309", "WBGene00017683", "Q18221", "WBGene00004782", "G5EGI1", "WBGene00011729", "Q17963", "WBGene00006474", "P34545", "WBGene00000366", "P28515", "WBGene00001249", "Q9N3S7", "WBGene00021636", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "Q9U2X0", "WBGene00013766", "P62784", "WBGene00001875", "Q10453", "WBGene00001945", "K7ZUH9", "WBGene00001914" ] }, "reaction_10568212": { "compartment": "compartment_7660", "id": "reaction_10568212", "reactome": "R-CEL-8936584", "name": "PRMT6 arginine methylates H3K4me2-Nucleosome at the ITGA2B gene promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10568198" ], "products": [ "species_77502", "species_10568209" ], "modifiers": [ [ "species_10568198", "catalyst" ] ], "additional_components": [ "A5JYW9", "WBGene00004117", "G5ECH0", "WBGene00001836", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "P62784", "WBGene00001875", "Q10453", "WBGene00001945", "K7ZUH9", "WBGene00001914", "A5JYW9", "WBGene00004117", "G5ECH0", "WBGene00001836", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "P62784", "WBGene00001875", "Q10453", "WBGene00001945", "K7ZUH9", "WBGene00001914", "A5JYW9", "WBGene00004117", "G5ECH0", "WBGene00001836", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "P62784", "WBGene00001875", "Q10453", "WBGene00001945", "K7ZUH9", "WBGene00001914" ] }, "reaction_10568228": { "compartment": "compartment_7660", "id": "reaction_10568228", "reactome": "R-CEL-8936621", "name": "Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10568223" ], "products": [ "species_77502", "species_10568225" ], "modifiers": [ [ "species_10568223", "catalyst" ] ], "additional_components": [ "Q10661", "WBGene00001088", "G5EFZ3", "WBGene00012458", "Q09309", "WBGene00017683", "Q18221", "WBGene00004782", "G5EGI1", "WBGene00011729", "Q17963", "WBGene00006474", "P34545", "WBGene00000366", "P28515", "WBGene00001249", "Q9N3S7", "WBGene00021636", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "Q9U2X0", "WBGene00013766", "P62784", "WBGene00001875", "Q10453", "WBGene00001945", "K7ZUH9", "WBGene00001914", "Q10661", "WBGene00001088", "G5EFZ3", "WBGene00012458", "Q09309", "WBGene00017683", "Q18221", "WBGene00004782", "G5EGI1", "WBGene00011729", "Q17963", "WBGene00006474", "P34545", "WBGene00000366", "P28515", "WBGene00001249", "Q9N3S7", "WBGene00021636", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "Q9U2X0", "WBGene00013766", "P62784", "WBGene00001875", "K7ZUH9", "WBGene00001914", "Q10453", "WBGene00001945", "Q10661", "WBGene00001088", "G5EFZ3", "WBGene00012458", "Q09309", "WBGene00017683", "Q18221", "WBGene00004782", "G5EGI1", "WBGene00011729", "Q17963", "WBGene00006474", "P34545", "WBGene00000366", "P28515", "WBGene00001249", "Q9N3S7", "WBGene00021636", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "Q9U2X0", "WBGene00013766", "P62784", "WBGene00001875", "Q10453", "WBGene00001945", "K7ZUH9", "WBGene00001914" ] }, "reaction_10568221": { "compartment": "compartment_7660", "id": "reaction_10568221", "reactome": "R-CEL-8936608", "name": "PRMT6 arginine methylates H3K4me2-Nucleosome at the GP1BA gene promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10568216" ], "products": [ "species_77502", "species_10568218" ], "modifiers": [ [ "species_10568216", "catalyst" ] ], "additional_components": [ "A5JYW9", "WBGene00004117", "G5ECH0", "WBGene00001836", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "P62784", "WBGene00001875", "Q10453", "WBGene00001945", "K7ZUH9", "WBGene00001914", "A5JYW9", "WBGene00004117", "G5ECH0", "WBGene00001836", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "P62784", "WBGene00001875", "Q10453", "WBGene00001945", "K7ZUH9", "WBGene00001914", "A5JYW9", "WBGene00004117", "G5ECH0", "WBGene00001836", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "P62784", "WBGene00001875", "Q10453", "WBGene00001945", "K7ZUH9", "WBGene00001914" ] }, "reaction_10568252": { "compartment": "compartment_7660", "id": "reaction_10568252", "reactome": "R-CEL-8937016", "name": "Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10568247" ], "products": [ "species_77502", "species_10568249" ], "modifiers": [ [ "species_10568247", "catalyst" ] ], "additional_components": [ "Q10661", "WBGene00001088", "G5EFZ3", "WBGene00012458", "Q09309", "WBGene00017683", "Q18221", "WBGene00004782", "G5EGI1", "WBGene00011729", "Q17963", "WBGene00006474", "P34545", "WBGene00000366", "P28515", "WBGene00001249", "Q9N3S7", "WBGene00021636", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "Q9U2X0", "WBGene00013766", "P62784", "WBGene00001875", "Q10453", "WBGene00001945", "K7ZUH9", "WBGene00001914", "Q10661", "WBGene00001088", "G5EFZ3", "WBGene00012458", "Q09309", "WBGene00017683", "Q18221", "WBGene00004782", "G5EGI1", "WBGene00011729", "Q17963", "WBGene00006474", "P34545", "WBGene00000366", "P28515", "WBGene00001249", "Q9N3S7", "WBGene00021636", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "Q9U2X0", "WBGene00013766", "P62784", "WBGene00001875", "K7ZUH9", "WBGene00001914", "Q10453", "WBGene00001945", "Q10661", "WBGene00001088", "G5EFZ3", "WBGene00012458", "Q09309", "WBGene00017683", "Q18221", "WBGene00004782", "G5EGI1", "WBGene00011729", "Q17963", "WBGene00006474", "P34545", "WBGene00000366", "P28515", "WBGene00001249", "Q9N3S7", "WBGene00021636", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "Q9U2X0", "WBGene00013766", "P62784", "WBGene00001875", "Q10453", "WBGene00001945", "K7ZUH9", "WBGene00001914" ] }, "reaction_10568268": { "compartment": "compartment_7660", "id": "reaction_10568268", "reactome": "R-CEL-8937050", "name": "Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10568263" ], "products": [ "species_77502", "species_10568265" ], "modifiers": [ [ "species_10568263", "catalyst" ] ], "additional_components": [ "Q10661", "WBGene00001088", "G5EFZ3", "WBGene00012458", "Q09309", "WBGene00017683", "Q18221", "WBGene00004782", "G5EGI1", "WBGene00011729", "Q17963", "WBGene00006474", "P34545", "WBGene00000366", "P28515", "WBGene00001249", "Q9N3S7", "WBGene00021636", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "Q9U2X0", "WBGene00013766", "P62784", "WBGene00001875", "Q10453", "WBGene00001945", "K7ZUH9", "WBGene00001914", "Q10661", "WBGene00001088", "G5EFZ3", "WBGene00012458", "Q09309", "WBGene00017683", "Q18221", "WBGene00004782", "G5EGI1", "WBGene00011729", "Q17963", "WBGene00006474", "P34545", "WBGene00000366", "P28515", "WBGene00001249", "Q9N3S7", "WBGene00021636", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "Q9U2X0", "WBGene00013766", "P62784", "WBGene00001875", "K7ZUH9", "WBGene00001914", "Q10453", "WBGene00001945", "Q10661", "WBGene00001088", "G5EFZ3", "WBGene00012458", "Q09309", "WBGene00017683", "Q18221", "WBGene00004782", "G5EGI1", "WBGene00011729", "Q17963", "WBGene00006474", "P34545", "WBGene00000366", "P28515", "WBGene00001249", "Q9N3S7", "WBGene00021636", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "Q9U2X0", "WBGene00013766", "P62784", "WBGene00001875", "Q10453", "WBGene00001945", "K7ZUH9", "WBGene00001914" ] }, "reaction_10567792": { "compartment": "compartment_7660", "id": "reaction_10567792", "reactome": "R-CEL-8878050", "name": "HIPK2 phosphorylates RUNX1 and EP300", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10567776" ], "products": [ "species_113582", "species_10567789" ], "modifiers": [ [ "species_10549016", "catalyst" ] ], "additional_components": [ "P34545", "WBGene00000366", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "P34545", "WBGene00000366", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "WBGene00001994" ] }, "reaction_10567794": { "compartment": "compartment_7660", "id": "reaction_10567794", "reactome": "R-CEL-8878054", "name": "HIPK2 phosphorylates RUNX1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10566201" ], "products": [ "species_113582", "species_10567787" ], "modifiers": [ [ "species_10549016", "catalyst" ] ], "additional_components": [ "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "WBGene00001994" ] }, "reaction_10567796": { "compartment": "compartment_7660", "id": "reaction_10567796", "reactome": "R-CEL-8878056", "name": "RUNX1:CBFB binds EP300", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10566201", "species_10532228" ], "products": [ "species_10567776" ], "modifiers": [], "additional_components": [ "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "WBGene00000366", "P34545", "WBGene00000366", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393" ] }, "reaction_10568377": { "compartment": "compartment_7660", "id": "reaction_10568377", "reactome": "R-CEL-8938217", "name": "RUNX1 binds the SWI/SNF complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546652", "species_10566201" ], "products": [ "species_10568375" ], "modifiers": [], "additional_components": [ "H8ESF3", "WBGene00004203", "Q21831", "WBGene00011111", "G5EF53", "WBGene00004204", "P91094", "WBGene00004106", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "H8ESF3", "WBGene00004203", "Q21831", "WBGene00011111", "G5EF53", "WBGene00004204", "P91094", "WBGene00004106" ] }, "reaction_10570134": { "compartment": "compartment_7660", "id": "reaction_10570134", "reactome": "R-CEL-8956639", "name": "RUNX1 binds YAP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10532633", "species_10566201" ], "products": [ "species_10570132" ], "modifiers": [ [ "species_10555896", "inhibitor" ] ], "additional_components": [ "WBGene00008748", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "Q19404", "WBGene00008748", "WBGene00000018" ] }, "reaction_10570141": { "compartment": "compartment_7660", "id": "reaction_10570141", "reactome": "R-CEL-8956659", "name": "ABL1 phosphorylates YAP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10532633" ], "products": [ "species_113582", "species_10570138" ], "modifiers": [ [ "species_10555896", "catalyst" ] ], "additional_components": [ "WBGene00008748", "WBGene00008748", "WBGene00000018" ] }, "reaction_10568381": { "compartment": "compartment_7660", "id": "reaction_10568381", "reactome": "R-CEL-8938231", "name": "RUNX1:CBFB binds CREBBP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10566201", "species_10532226" ], "products": [ "species_10568379" ], "modifiers": [], "additional_components": [ "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "WBGene00000366", "P34545", "WBGene00000366", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393" ] }, "reaction_10552368": { "compartment": "compartment_7660", "id": "reaction_10552368", "reactome": "R-CEL-5444523", "name": "Formation of MSH1:PMS2 Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10551625", "species_10551620" ], "products": [ "species_10551627" ], "modifiers": [], "additional_components": [ "WBGene00004064", "WBGene00003373", "Q9XU10", "WBGene00003373", "G5EFG5", "WBGene00004064" ] }, "reaction_10551667": { "compartment": "compartment_7660", "id": "reaction_10551667", "reactome": "R-CEL-5358597", "name": "EXO1 interacts with MSH2:MSH6 (MutSalpha) and MLH1:PMS2 (MutLalpha)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10551663", "species_10551647" ], "products": [ "species_10551665" ], "modifiers": [], "additional_components": [ "WBGene00009731", "Q9TXR4", "WBGene00003418", "Q9N3T8", "WBGene00003422", "species_29358", "Q9XU10", "WBGene00003373", "G5EFG5", "WBGene00004064", "O02115", "WBGene00003955", "Q9TXR4", "WBGene00003418", "Q9N3T8", "WBGene00003422", "species_29358", "Q9XU10", "WBGene00003373", "G5EFG5", "WBGene00004064", "O02115", "WBGene00003955", "O62245", "WBGene00009731" ] }, "reaction_10551650": { "compartment": "compartment_7660", "id": "reaction_10551650", "reactome": "R-CEL-5358518", "name": "MLH1:PMS2 makes single strand incision near 1-2 base mismatch", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10551643" ], "products": [ "species_10551647" ], "modifiers": [ [ "species_10551643", "catalyst" ] ], "additional_components": [ "Q9TXR4", "WBGene00003418", "Q9N3T8", "WBGene00003422", "species_29358", "Q9XU10", "WBGene00003373", "G5EFG5", "WBGene00004064", "O02115", "WBGene00003955", "Q9TXR4", "WBGene00003418", "Q9N3T8", "WBGene00003422", "species_29358", "Q9XU10", "WBGene00003373", "G5EFG5", "WBGene00004064", "O02115", "WBGene00003955", "Q9TXR4", "WBGene00003418", "Q9N3T8", "WBGene00003422", "species_29358", "Q9XU10", "WBGene00003373", "G5EFG5", "WBGene00004064", "O02115", "WBGene00003955" ] }, "reaction_10551669": { "compartment": "compartment_7660", "id": "reaction_10551669", "reactome": "R-CEL-5358912", "name": "MSH2:MSH6 exchanges ADP for ATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10551654" ], "products": [ "species_113582", "species_10551641" ], "modifiers": [], "additional_components": [ "Q9TXR4", "WBGene00003418", "Q9N3T8", "WBGene00003422", "species_113582", "Q9TXR4", "WBGene00003418", "Q9N3T8", "WBGene00003422", "species_29358" ] }, "reaction_10551656": { "compartment": "compartment_7660", "id": "reaction_10551656", "reactome": "R-CEL-5358525", "name": "MSH2:MSH6 binds 1 base mismatch or 1-2 base insertion/deletion loop", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10551652", "species_5358514" ], "products": [ "species_10551654" ], "modifiers": [], "additional_components": [ "Q9TXR4", "WBGene00003418", "Q9N3T8", "WBGene00003422", "species_113582", "Q9TXR4", "WBGene00003418", "Q9N3T8", "WBGene00003422", "species_113582" ] }, "reaction_10551645": { "compartment": "compartment_7660", "id": "reaction_10551645", "reactome": "R-CEL-5358510", "name": "MSH2:MSH6 recruits MLH1:PMS2 to mismatch and interacts with PCNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502653", "species_10551627", "species_10551641" ], "products": [ "species_10551643" ], "modifiers": [], "additional_components": [ "O02115", "WBGene00003955", "Q9XU10", "WBGene00003373", "G5EFG5", "WBGene00004064", "Q9TXR4", "WBGene00003418", "Q9N3T8", "WBGene00003422", "species_29358", "Q9TXR4", "WBGene00003418", "Q9N3T8", "WBGene00003422", "species_29358", "Q9XU10", "WBGene00003373", "G5EFG5", "WBGene00004064", "O02115", "WBGene00003955" ] }, "reaction_10552366": { "compartment": "compartment_7660", "id": "reaction_10552366", "reactome": "R-CEL-5444516", "name": "Formation of MSH2:MSH6 Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113582", "species_10551637", "species_10551632" ], "products": [ "species_10551652" ], "modifiers": [], "additional_components": [ "WBGene00003422", "WBGene00003418", "Q9TXR4", "WBGene00003418", "Q9N3T8", "WBGene00003422", "species_113582" ] }, "reaction_10521473": { "compartment": "compartment_70101", "id": "reaction_10521473", "reactome": "R-CEL-399951", "name": "Phosphorylation of CRMPs by GSK3beta", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10521396" ], "products": [ "species_10521470", "species_29370" ], "modifiers": [ [ "species_10513574", "catalyst" ] ], "additional_components": [ "O45657", "WBGene00004048", "U4PRY7", "WBGene00004047", "G5ECH7", "WBGene00000407", "Q22695", "WBGene00011955", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q18677", "WBGene00000964", "Q21773", "WBGene00000963", "Q01630", "WBGene00006769", "Q95XP4", "WBGene00003111", "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "Q95XP4", "WBGene00003111", "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "O45657", "WBGene00004048", "U4PRY7", "WBGene00004047", "Q18677", "WBGene00000964", "Q21773", "WBGene00000963", "Q01630", "WBGene00006769", "G5ECH7", "WBGene00000407", "Q22695", "WBGene00011955", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q9U2Q9", "WBGene00001746", "Q09595", "WBGene00010991", "Q93372", "WBGene00010991" ] }, "reaction_10521399": { "compartment": "compartment_70101", "id": "reaction_10521399", "reactome": "R-CEL-399944", "name": "Phosphorylation of CRMPs by Cdk5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10521323", "species_113592", "species_10521345" ], "products": [ "species_29370", "species_10521396" ], "modifiers": [ [ "species_10521345", "catalyst" ] ], "additional_components": [ "Q18677", "WBGene00000964", "Q21773", "WBGene00000963", "Q01630", "WBGene00006769", "Q95XP4", "WBGene00003111", "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "O45657", "WBGene00004048", "U4PRY7", "WBGene00004047", "G5ECH7", "WBGene00000407", "Q22695", "WBGene00011955", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "O45657", "WBGene00004048", "U4PRY7", "WBGene00004047", "G5ECH7", "WBGene00000407", "Q22695", "WBGene00011955", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q18677", "WBGene00000964", "Q21773", "WBGene00000963", "Q01630", "WBGene00006769", "Q95XP4", "WBGene00003111", "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "Q95XP4", "WBGene00003111", "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "O45657", "WBGene00004048", "U4PRY7", "WBGene00004047", "G5ECH7", "WBGene00000407", "Q22695", "WBGene00011955", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635" ] }, "reaction_10521435": { "compartment": "compartment_70101", "id": "reaction_10521435", "reactome": "R-CEL-399947", "name": "Tyrosine phosphorylation of CRMPs by Fes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10521323", "species_113592", "species_10521204" ], "products": [ "species_29370", "species_10521432" ], "modifiers": [ [ "species_10516270", "catalyst" ] ], "additional_components": [ "Q18677", "WBGene00000964", "Q21773", "WBGene00000963", "Q01630", "WBGene00006769", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "U4PRY7", "WBGene00004047", "O45657", "WBGene00004048", "Q95XP4", "WBGene00003111", "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "O01325", "WBGene00009160", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "U4PRY7", "WBGene00004047", "O45657", "WBGene00004048", "Q95XP4", "WBGene00003111", "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "O01325", "WBGene00009160", "Q21773", "WBGene00000963", "Q01630", "WBGene00006769", "Q18677", "WBGene00000964", "WBGene00009160" ] }, "reaction_10503744": { "compartment": "compartment_70101", "id": "reaction_10503744", "reactome": "R-CEL-71130", "name": "q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_71129", "species_73473" ], "products": [ "species_29870", "species_29360" ], "modifiers": [ [ "species_10503741", "catalyst" ] ], "additional_components": [ "Q9XVJ3", "WBGene00011398" ] }, "reaction_10503734": { "compartment": "compartment_70101", "id": "reaction_10503734", "reactome": "R-CEL-71118", "name": "PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29870", "species_29502", "species_29368" ], "products": [ "species_71112", "species_29506" ], "modifiers": [ [ "species_10503731", "catalyst" ] ], "additional_components": [ "P90925", "WBGene00000240", "species_113531" ] }, "reaction_10528409": { "compartment": "compartment_70101", "id": "reaction_10528409", "reactome": "R-CEL-893593", "name": "phenylalanine + pyruvate => 3-(indol-3-yl)pyruvate + alanine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29502", "species_29398" ], "products": [ "species_29432", "species_893599" ], "modifiers": [ [ "species_10528406", "catalyst" ] ], "additional_components": [ "Q9XX97", "WBGene00009232", "Q8MP09", "WBGene00010984" ] }, "reaction_10503754": { "compartment": "compartment_70101", "id": "reaction_10503754", "reactome": "R-CEL-71146", "name": "4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71112" ], "products": [ "species_29356", "species_71129" ], "modifiers": [ [ "species_10503751", "catalyst" ] ], "additional_components": [ "Q9TZH6", "WBGene00020397" ] }, "reaction_10507618": { "compartment": "compartment_17951", "id": "reaction_10507618", "reactome": "R-CEL-76031", "name": "2 H2O2 => O2 + 2 H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113575" ], "products": [ "species_113535", "species_141343" ], "modifiers": [ [ "species_10507615", "catalyst" ] ], "additional_components": [ "species_71185", "species_29364", "Q8MYL7", "WBGene00013220" ] }, "reaction_10548068": { "compartment": "compartment_17927", "id": "reaction_10548068", "reactome": "R-CEL-3777112", "name": "SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_3341308", "species_163953" ], "products": [ "species_189481", "species_189461" ], "modifiers": [ [ "species_10548065", "catalyst" ] ], "additional_components": [ "species_209799", "species_216785", "P34697", "WBGene00004930", "Q27538", "WBGene00007036" ] }, "reaction_10547432": { "compartment": "compartment_5460", "id": "reaction_10547432", "reactome": "R-CEL-3323079", "name": "GSR catalyzes glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113529", "species_1655882", "species_113600" ], "products": [ "species_113563", "species_1655887" ], "modifiers": [ [ "species_10547429", "catalyst" ] ], "additional_components": [ "Q93379", "WBGene00008117", "species_113596" ] }, "reaction_10549770": { "compartment": "compartment_17963", "id": "reaction_10549770", "reactome": "R-CEL-4837364", "name": "Secretion of SOD3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10549768" ], "products": [ "species_10547194" ], "modifiers": [], "additional_components": [ "P34697", "WBGene00004930", "species_216785", "species_209799", "species_216785", "P34697", "WBGene00004930", "species_209799" ] }, "reaction_10547467": { "compartment": "compartment_70101", "id": "reaction_10547467", "reactome": "R-CEL-3343700", "name": "PRDX6:GSTP1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29450", "species_29408" ], "products": [ "species_29356", "species_111745" ], "modifiers": [ [ "species_10547464", "catalyst" ] ], "additional_components": [ "Q8MXT1", "WBGene00021401", "P10299", "WBGene00001749" ] }, "reaction_10547212": { "compartment": "compartment_70101", "id": "reaction_10547212", "reactome": "R-CEL-3299691", "name": "SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_1222424" ], "products": [ "species_29368", "species_29408" ], "modifiers": [ [ "species_10547209", "catalyst" ] ], "additional_components": [ "species_216785", "species_209799", "P34697", "WBGene00004930", "Q27538", "WBGene00007036" ] }, "reaction_10547438": { "compartment": "compartment_70616", "id": "reaction_10547438", "reactome": "R-CEL-3341294", "name": "Superoxide reduces cytochrome c", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10510159", "species_3341308" ], "products": [ "species_10510157", "species_189461" ], "modifiers": [], "additional_components": [ "CHEBI:38574", "P19974", "WBGene00017121", "Q23240", "WBGene00013854", "CHEBI:38573", "P19974", "WBGene00017121", "Q23240", "WBGene00013854" ] }, "reaction_10547186": { "compartment": "compartment_5460", "id": "reaction_10547186", "reactome": "R-CEL-3299680", "name": "SOD2 catalyzes 2H+ + 2O2.- => O2 + H2O2 (mitochondrial matrix)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113529", "species_3299683" ], "products": [ "species_113533", "species_1614617" ], "modifiers": [ [ "species_10547183", "catalyst" ] ], "additional_components": [ "species_266099", "P31161", "WBGene00004931" ] }, "reaction_10547411": { "compartment": "compartment_5460", "id": "reaction_10547411", "reactome": "R-CEL-3322995", "name": "PRDX3,5 catalyze TXN2 reduced + H2O2 => TXN2 oxidized + 2H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10547396", "species_1614617" ], "products": [ "species_10547399", "species_113521" ], "modifiers": [ [ "species_10547408", "catalyst" ] ], "additional_components": [ "WBGene00007099", "WBGene00007099", "Q21824", "WBGene00011110" ] }, "reaction_10557597": { "compartment": "compartment_5460", "id": "reaction_10557597", "reactome": "R-CEL-5696197", "name": "NUDT2 hydrolyses GP4G to GTP, GMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5696199", "species_113521" ], "products": [ "species_5696194", "species_113573" ], "modifiers": [ [ "species_10557594", "catalyst" ] ], "additional_components": [ "WBGene00003581" ] }, "reaction_10547197": { "compartment": "compartment_984", "id": "reaction_10547197", "reactome": "R-CEL-3299682", "name": "SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_3299686" ], "products": [ "species_351629", "species_352327" ], "modifiers": [ [ "species_10547194", "catalyst" ] ], "additional_components": [ "species_216785", "P34697", "WBGene00004930", "species_209799" ] }, "reaction_10547423": { "compartment": "compartment_5460", "id": "reaction_10547423", "reactome": "R-CEL-3323050", "name": "TXNRD2 catalyzes the reduction of TXN2 by NADPH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113529", "species_10547399", "species_113600" ], "products": [ "species_113563", "species_10547396" ], "modifiers": [ [ "species_10547420", "catalyst" ] ], "additional_components": [ "WBGene00007099", "WBGene00007099", "P30635", "WBGene00014028", "species_113596" ] }, "reaction_10502803": { "compartment": "compartment_7660", "id": "reaction_10502803", "reactome": "R-CEL-69608", "name": "Phosphorylation of Cdc25A at Ser-123 by Chk2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10502759" ], "products": [ "species_113582", "species_10502781" ], "modifiers": [ [ "species_10502800", "catalyst" ] ], "additional_components": [ "WBGene00000389", "WBGene00000389", "WBGene00000499" ] }, "reaction_10502779": { "compartment": "compartment_70101", "id": "reaction_10502779", "reactome": "R-CEL-69600", "name": "Proteolytic degradation of ubiquitinated-Cdc25A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502777" ], "products": [ "species_10502375" ], "modifiers": [ [ "species_10502572", "catalyst" ] ], "additional_components": [ "Q21762", "WBGene00000389", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "P91477", "WBGene00003950", "Q95PZ7", "WBGene00013435", "Q18115", "WBGene00004459", "O62102", "WBGene00003948", "O17071", "WBGene00004504", "Q10920", "WBGene00016623", "P34286", "WBGene00003952", "Q9XTT9", "WBGene00004506", "Q23449", "WBGene00004468", "Q95005", "WBGene00003925", "P46502", "WBGene00004503", "O61792", "WBGene00004464", "O17586", "WBGene00003922", "O76371", "WBGene00004505", "Q20585", "WBGene00004463", "Q95008", "WBGene00003926", "Q18787", "WBGene00004501", "Q20058", "WBGene00009445", "Q9N599", "WBGene00003924", "O16368", "WBGene00004502", "O61742", "WBGene00004466", "Q09583", "WBGene00003928", "Q966I8", "WBGene00003947", "Q04908", "WBGene00004460", "Q9XUV0", "WBGene00003951", "Q27488", "WBGene00003923", "Q9GZH5", "WBGene00004458", "O44156", "WBGene00003927", "Q22253", "WBGene00004465", "O76577", "WBGene00004467", "P90868", "WBGene00003953", "Q19324", "WBGene00004461", "Q17971", "WBGene00007588", "Q23237", "WBGene00003949", "Q20938", "WBGene00004462" ] }, "reaction_10557688": { "compartment": "compartment_7660", "id": "reaction_10557688", "reactome": "R-CEL-5696655", "name": "PARP1 or PARP2 PARylates DDB2 and autoPARylates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10557686", "species_427523" ], "products": [ "species_427497", "species_10556156" ], "modifiers": [], "additional_components": [ "Q21554", "WBGene00010890", "Q23457", "WBGene00004320", "Q17392", "WBGene00000839", "P30644", "WBGene00011145", "Q23451", "WBGene00013924", "Q9N4C3", "WBGene00022296", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "Q23457", "WBGene00004320", "Q17392", "WBGene00000839", "Q21554", "WBGene00010890", "P30644", "WBGene00011145", "Q23451", "WBGene00013924", "Q9N4C3", "WBGene00022296", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725" ] }, "reaction_10556733": { "compartment": "compartment_7660", "id": "reaction_10556733", "reactome": "R-CEL-5691004", "name": "XPC binds RAD23 and CETN2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10549311", "species_10556067", "species_10549280" ], "products": [ "species_10556731" ], "modifiers": [], "additional_components": [ "WBGene00022296", "WBGene00013924", "WBGene00011145", "P30644", "WBGene00011145", "Q23451", "WBGene00013924", "Q9N4C3", "WBGene00022296" ] }, "reaction_10556781": { "compartment": "compartment_7660", "id": "reaction_10556781", "reactome": "R-CEL-5691006", "name": "XPC:RAD23:CETN2 and UV-DDB bind distorted dsDNA site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10556731", "species_10556777", "species_5688114" ], "products": [ "species_10556779", "species_10556775" ], "modifiers": [], "additional_components": [ "P30644", "WBGene00011145", "Q23451", "WBGene00013924", "Q9N4C3", "WBGene00022296", "Q21554", "WBGene00010890", "Q23457", "WBGene00004320", "Q17392", "WBGene00000839", "Q9GS00", "WBGene00000813", "Q9N359", "WBGene00000816", "P91001", "WBGene00000817", "O01422", "WBGene00000814", "Q9N425", "WBGene00000815", "Q95PZ0", "WBGene00000818", "Q21554", "WBGene00010890", "Q23457", "WBGene00004320", "Q17392", "WBGene00000839", "P30644", "WBGene00011145", "Q23451", "WBGene00013924", "Q9N4C3", "WBGene00022296", "Q9GS00", "WBGene00000813", "Q9N359", "WBGene00000816", "P91001", "WBGene00000817", "O01422", "WBGene00000814", "Q9N425", "WBGene00000815", "Q95PZ0", "WBGene00000818" ] }, "reaction_10557965": { "compartment": "compartment_7660", "id": "reaction_10557965", "reactome": "R-CEL-6782943", "name": "UV-DDB ubiquitinates XPC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502318", "species_10556779" ], "products": [ "species_10557684" ], "modifiers": [ [ "species_10556779", "catalyst" ] ], "additional_components": [ "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "Q21554", "WBGene00010890", "Q23457", "WBGene00004320", "Q17392", "WBGene00000839", "P30644", "WBGene00011145", "Q23451", "WBGene00013924", "Q9N4C3", "WBGene00022296", "Q21554", "WBGene00010890", "Q23457", "WBGene00004320", "Q17392", "WBGene00000839", "P30644", "WBGene00011145", "Q23451", "WBGene00013924", "Q9N4C3", "WBGene00022296", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "Q21554", "WBGene00010890", "Q23457", "WBGene00004320", "Q17392", "WBGene00000839", "P30644", "WBGene00011145", "Q23451", "WBGene00013924", "Q9N4C3", "WBGene00022296" ] }, "reaction_10537696": { "compartment": "compartment_876", "id": "reaction_10537696", "reactome": "R-CEL-1855213", "name": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_994170" ], "products": [ "species_29372", "species_994123" ], "modifiers": [ [ "species_10537691", "catalyst" ] ], "additional_components": [ "WBGene00007620" ] }, "reaction_10537745": { "compartment": "compartment_876", "id": "reaction_10537745", "reactome": "R-CEL-1855221", "name": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_179856" ], "products": [ "species_114520", "species_114519" ], "modifiers": [ [ "species_10537742", "catalyst" ] ], "additional_components": [ "G5EFI8", "WBGene00004036", "species_74016", "Q22070", "WBGene00004038" ] }, "reaction_10537729": { "compartment": "compartment_70101", "id": "reaction_10537729", "reactome": "R-CEL-1855218", "name": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_994170" ], "products": [ "species_29372", "species_994123" ], "modifiers": [ [ "species_10537603", "catalyst" ] ], "additional_components": [ "O17590", "WBGene00007620", "P34370", "WBGene00086546", "G5ECL2", "WBGene00006763" ] }, "reaction_10537619": { "compartment": "compartment_70101", "id": "reaction_10537619", "reactome": "R-CEL-1855177", "name": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_179856" ], "products": [ "species_114520", "species_114519" ], "modifiers": [ [ "species_10537616", "catalyst" ] ], "additional_components": [ "species_74016", "G5EBH0", "WBGene00001177" ] }, "reaction_10537513": { "compartment": "compartment_70101", "id": "reaction_10537513", "reactome": "R-CEL-1855153", "name": "I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by ITPKA/B/C in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_114520" ], "products": [ "species_29370", "species_994170" ], "modifiers": [ [ "species_10537510", "catalyst" ] ], "additional_components": [ "species_74016", "Q95Q62", "WBGene00002979", "Q11083", "WBGene00020378", "P04630", "WBGene00000285", "G5EF37", "WBGene00003934", "A0A2C9C3L3", "WBGene00020378", "Q18136", "WBGene00006861", "Q09665", "WBGene00006583", "O02159", "WBGene00020378", "G5EDZ8", "WBGene00000288", "Q94288", "WBGene00000287", "Q09980", "WBGene00017394", "O16305", "WBGene00000552", "G5EEG0", "WBGene00000286" ] }, "reaction_10537723": { "compartment": "compartment_12045", "id": "reaction_10537723", "reactome": "R-CEL-1855214", "name": "PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2023856", "species_29356" ], "products": [ "species_114520", "species_1500596" ], "modifiers": [ [ "species_10537720", "catalyst" ] ], "additional_components": [ "Q8I4C7", "WBGene00020256", "H2KZ05", "WBGene00020256", "O17405", "WBGene00017316", "Q19056", "WBGene00020256", "species_74016" ] }, "reaction_10537677": { "compartment": "compartment_70101", "id": "reaction_10537677", "reactome": "R-CEL-1855205", "name": "I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_994170" ], "products": [ "species_29372", "species_114520" ], "modifiers": [ [ "species_10537674", "catalyst" ] ], "additional_components": [ "species_114632", "G5EE01", "WBGene00000913" ] }, "reaction_10572147": { "compartment": "compartment_12045", "id": "reaction_10572147", "reactome": "R-CEL-9614271", "name": "Autocleavage of ADGRG6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10572138" ], "products": [ "species_10572144" ], "modifiers": [ [ "species_10572138", "catalyst" ] ], "additional_components": [ "WBGene00017947", "Q19930", "WBGene00017947", "WBGene00017947" ] }, "reaction_10572149": { "compartment": "compartment_876", "id": "reaction_10572149", "reactome": "R-CEL-9614273", "name": "ADGRG heterodimer translocates to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10572144" ], "products": [ "species_10572144" ], "modifiers": [], "additional_components": [ "Q19930", "WBGene00017947", "Q19930", "WBGene00017947" ] }, "reaction_10519185": { "compartment": "compartment_984", "id": "reaction_10519185", "reactome": "R-CEL-375160", "name": "NCAM1 binds to ATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_114570", "species_10518758" ], "products": [ "species_10519183" ], "modifiers": [], "additional_components": [ "WBGene00004372", "C6KRM7", "WBGene00004372", "species_29358" ] }, "reaction_10519181": { "compartment": "compartment_984", "id": "reaction_10519181", "reactome": "R-CEL-375151", "name": "Interaction of NCAM1 with collagens", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10519177", "species_10518758" ], "products": [ "species_10519179" ], "modifiers": [], "additional_components": [ "Q9N4U2", "WBGene00000647", "O76368", "WBGene00000674", "Q09457", "WBGene00000251", "P17140", "WBGene00002280", "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689", "WBGene00004372", "C6KRM7", "WBGene00004372", "Q9N4U2", "WBGene00000647", "O76368", "WBGene00000674", "Q09457", "WBGene00000251", "P17140", "WBGene00002280", "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689" ] }, "reaction_10520993": { "compartment": "compartment_70101", "id": "reaction_10520993", "reactome": "R-CEL-392054", "name": "NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10512175", "species_29438" ], "products": [ "species_29420", "species_10511481" ], "modifiers": [ [ "species_10520988", "catalyst" ] ], "additional_components": [ "species_29420", "P22981", "WBGene00002335", "species_29438", "P22981", "WBGene00002335", "E0AHA7", "WBGene00006803", "G5EFW3", "WBGene00004855", "Q21408", "WBGene00004951", "Q7YZG5", "WBGene00021702", "C6KRM7", "WBGene00004372", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "P29355", "WBGene00004774", "Q9N5D3", "WBGene00004947", "Q95YD4", "WBGene00002213" ] }, "reaction_10520984": { "compartment": "compartment_70101", "id": "reaction_10520984", "reactome": "R-CEL-392051", "name": "Recruitment of Grb2 to pFAK:NCAM1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10506871", "species_10520978" ], "products": [ "species_10520982" ], "modifiers": [], "additional_components": [ "WBGene00004774", "E0AHA7", "WBGene00006803", "G5EFW3", "WBGene00004855", "Q21408", "WBGene00004951", "Q7YZG5", "WBGene00021702", "C6KRM7", "WBGene00004372", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q95YD4", "WBGene00002213", "E0AHA7", "WBGene00006803", "G5EFW3", "WBGene00004855", "Q21408", "WBGene00004951", "Q7YZG5", "WBGene00021702", "C6KRM7", "WBGene00004372", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "P29355", "WBGene00004774", "Q95YD4", "WBGene00002213" ] }, "reaction_10520990": { "compartment": "compartment_70101", "id": "reaction_10520990", "reactome": "R-CEL-392053", "name": "SOS binds Grb2 bound to pFAK:NCAM1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10506876", "species_10520982" ], "products": [ "species_10520988" ], "modifiers": [], "additional_components": [ "WBGene00004947", "E0AHA7", "WBGene00006803", "G5EFW3", "WBGene00004855", "Q21408", "WBGene00004951", "Q7YZG5", "WBGene00021702", "C6KRM7", "WBGene00004372", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "P29355", "WBGene00004774", "Q95YD4", "WBGene00002213", "E0AHA7", "WBGene00006803", "G5EFW3", "WBGene00004855", "Q21408", "WBGene00004951", "Q7YZG5", "WBGene00021702", "C6KRM7", "WBGene00004372", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "P29355", "WBGene00004774", "Q9N5D3", "WBGene00004947", "Q95YD4", "WBGene00002213" ] }, "reaction_10570819": { "compartment": "compartment_984", "id": "reaction_10570819", "reactome": "R-CEL-9010815", "name": "SLITs bind keratan sulfate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10519315", "species_2299699" ], "products": [ "species_10570817" ], "modifiers": [], "additional_components": [ "WBGene00004854", "species_2299699", "G5EFX6", "WBGene00004854" ] }, "reaction_10523182": { "compartment": "compartment_876", "id": "reaction_10523182", "reactome": "R-CEL-428518", "name": "Glypican-1 (GPC1) binds SLIT2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10523178", "species_10519315" ], "products": [ "species_10523180" ], "modifiers": [], "additional_components": [ "G5EGU4", "WBGene00001687", "Q18530", "WBGene00003056", "CHEBI:17421", "WBGene00004854", "G5EFX6", "WBGene00004854", "G5EGU4", "WBGene00001687", "Q18530", "WBGene00003056", "CHEBI:17421" ] }, "reaction_10571295": { "compartment": "compartment_984", "id": "reaction_10571295", "reactome": "R-CEL-9014812", "name": "ROBOs bind keratan sulfate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10523160", "species_2299699" ], "products": [ "species_10571293" ], "modifiers": [], "additional_components": [ "WBGene00004732", "species_2299699", "Q53U87", "WBGene00004732" ] }, "reaction_10521289": { "compartment": "compartment_70101", "id": "reaction_10521289", "reactome": "R-CEL-399939", "name": "Autophosphorylation of PAK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10521208" ], "products": [ "species_29370", "species_10521286" ], "modifiers": [ [ "species_10521208", "catalyst" ] ], "additional_components": [ "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "species_29438", "Q03206", "ced-10", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "U4PRY7", "WBGene00004047", "O45657", "WBGene00004048", "Q95XP4", "WBGene00003111", "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "O01325", "WBGene00009160", "Q17850", "WBGene00003911", "G5EGQ3", "WBGene00003144", "species_29438", "Q03206", "ced-10", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "U4PRY7", "WBGene00004047", "O45657", "WBGene00004048", "Q95XP4", "WBGene00003111", "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "O01325", "WBGene00009160", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "species_29438", "Q03206", "ced-10", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "U4PRY7", "WBGene00004047", "O45657", "WBGene00004048", "Q95XP4", "WBGene00003111", "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "O01325", "WBGene00009160" ] }, "reaction_10521210": { "compartment": "compartment_70101", "id": "reaction_10521210", "reactome": "R-CEL-399930", "name": "Activation of PAK by Rac1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10520686", "species_10521206" ], "products": [ "species_10521208", "species_10520688" ], "modifiers": [], "additional_components": [ "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "species_29438", "Q03206", "ced-10", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "U4PRY7", "WBGene00004047", "O45657", "WBGene00004048", "Q95XP4", "WBGene00003111", "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "O01325", "WBGene00009160", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "species_29438", "Q03206", "ced-10", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "U4PRY7", "WBGene00004047", "O45657", "WBGene00004048", "Q95XP4", "WBGene00003111", "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "O01325", "WBGene00009160", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911" ] }, "reaction_10521249": { "compartment": "compartment_876", "id": "reaction_10521249", "reactome": "R-CEL-399933", "name": "Sema3A binds Nrp-1 bound to PlexinA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10521243", "species_10521174" ], "products": [ "species_10521247", "species_10521239" ], "modifiers": [], "additional_components": [ "O45657", "WBGene00004048", "U4PRY7", "WBGene00004047", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "O17905", "WBGene00001490", "Q95XP4", "WBGene00003111", "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "Q95XP4", "WBGene00003111", "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "O45657", "WBGene00004048", "U4PRY7", "WBGene00004047", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "WBGene00001490" ] }, "reaction_10521260": { "compartment": "compartment_70101", "id": "reaction_10521260", "reactome": "R-CEL-399936", "name": "Inhibition of integrin activation by sequestering PIP5KIgamma", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10521256", "species_10521239" ], "products": [ "species_10521258", "species_10518194" ], "modifiers": [], "additional_components": [ "G5EGK1", "WBGene00006771", "O01759", "WBGene00004087", "WBGene00001490", "O01759", "WBGene00004087", "O17905", "WBGene00001490", "WBGene00006771" ] }, "reaction_10521608": { "compartment": "compartment_70101", "id": "reaction_10521608", "reactome": "R-CEL-416588", "name": "Activation of Rho by LARG and PDZ-RhoGEF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10521599", "species_29438" ], "products": [ "species_29420", "species_10509488" ], "modifiers": [ [ "species_10521605", "catalyst" ] ], "additional_components": [ "species_29420", "Q22038", "WBGene00004357", "Q22038", "WBGene00004357", "species_29438", "P24348", "WBGene00002299", "O45657", "WBGene00004048", "U4PRY7", "WBGene00004047", "Q17330", "WBGene00004889", "Q95XP4", "WBGene00003111", "Q9TYS4", "WBGene00004890", "G5EFE1", "WBGene00006468", "H2L0P5", "WBGene00022391" ] }, "reaction_10521610": { "compartment": "compartment_70101", "id": "reaction_10521610", "reactome": "R-CEL-416594", "name": "LARG and PDZ-RhoGEF binds to Plexin-B1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10521603", "species_10521601" ], "products": [ "species_10521605" ], "modifiers": [], "additional_components": [ "G5EFE1", "WBGene00006468", "H2L0P5", "WBGene00022391", "P24348", "WBGene00002299", "O45657", "WBGene00004048", "U4PRY7", "WBGene00004047", "Q17330", "WBGene00004889", "Q95XP4", "WBGene00003111", "Q9TYS4", "WBGene00004890", "P24348", "WBGene00002299", "O45657", "WBGene00004048", "U4PRY7", "WBGene00004047", "Q17330", "WBGene00004889", "Q95XP4", "WBGene00003111", "Q9TYS4", "WBGene00004890", "G5EFE1", "WBGene00006468", "H2L0P5", "WBGene00022391" ] }, "reaction_10518622": { "compartment": "compartment_70101", "id": "reaction_10518622", "reactome": "R-CEL-373750", "name": "SEMA4D interacts with Plexin-B1:ErbB2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10518607", "species_10518591", "species_113592" ], "products": [ "species_10518619", "species_29370" ], "modifiers": [ [ "species_10518607", "catalyst" ] ], "additional_components": [ "P24348", "WBGene00002299", "O45657", "WBGene00004048", "U4PRY7", "WBGene00004047", "Q17330", "WBGene00004889", "Q95XP4", "WBGene00003111", "Q9TYS4", "WBGene00004890", "P24348", "WBGene00002299", "O45657", "WBGene00004048", "U4PRY7", "WBGene00004047", "Q17330", "WBGene00004889", "Q95XP4", "WBGene00003111", "Q9TYS4", "WBGene00004890", "P24348", "WBGene00002299", "O45657", "WBGene00004048", "U4PRY7", "WBGene00004047" ] }, "reaction_10521585": { "compartment": "compartment_70101", "id": "reaction_10521585", "reactome": "R-CEL-416546", "name": "Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10521574" ], "products": [ "species_29372", "species_10521576" ], "modifiers": [ [ "species_10521582", "catalyst" ] ], "additional_components": [ "G5EBK8", "WBGene00004310", "species_29438", "species_29420", "G5EBK8", "WBGene00004310", "Q9XVQ7", "WBGene00008711", "O45657", "WBGene00004048", "U4PRY7", "WBGene00004047", "Q17330", "WBGene00004889", "Q95XP4", "WBGene00003111", "Q9TYS4", "WBGene00004890", "species_29438" ] }, "reaction_10521963": { "compartment": "compartment_70101", "id": "reaction_10521963", "reactome": "R-CEL-419646", "name": "SEMA4D interacts with Plexin-B1:Met", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10518591", "species_113592", "species_10521960" ], "products": [ "species_29370", "species_10521546" ], "modifiers": [ [ "species_10521960", "catalyst" ] ], "additional_components": [ "Q17330", "WBGene00004889", "Q95XP4", "WBGene00003111", "Q9TYS4", "WBGene00004890", "Q9XVQ7", "WBGene00008711", "O45657", "WBGene00004048", "U4PRY7", "WBGene00004047", "Q9XVQ7", "WBGene00008711", "O45657", "WBGene00004048", "U4PRY7", "WBGene00004047", "Q17330", "WBGene00004889", "Q95XP4", "WBGene00003111", "Q9TYS4", "WBGene00004890", "Q9XVQ7", "WBGene00008711", "O45657", "WBGene00004048", "U4PRY7", "WBGene00004047" ] }, "reaction_10521595": { "compartment": "compartment_70101", "id": "reaction_10521595", "reactome": "R-CEL-416559", "name": "Inactivation of Rho-GTP by p190RhoGAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10509488" ], "products": [ "species_10509486", "species_29372" ], "modifiers": [ [ "species_10521592", "catalyst" ] ], "additional_components": [ "Q22038", "WBGene00004357", "species_29438", "Q22038", "WBGene00004357", "species_29420", "O45611", "WBGene00010374", "Q9XVQ7", "WBGene00008711", "O45657", "WBGene00004048", "U4PRY7", "WBGene00004047", "Q17330", "WBGene00004889", "Q95XP4", "WBGene00003111", "Q9TYS4", "WBGene00004890", "species_29438" ] }, "reaction_10521597": { "compartment": "compartment_70101", "id": "reaction_10521597", "reactome": "R-CEL-416562", "name": "p190RhoGAP binds Plexin-B1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10521582", "species_10521590" ], "products": [ "species_10521592" ], "modifiers": [], "additional_components": [ "Q9XVQ7", "WBGene00008711", "O45657", "WBGene00004048", "U4PRY7", "WBGene00004047", "Q17330", "WBGene00004889", "Q95XP4", "WBGene00003111", "Q9TYS4", "WBGene00004890", "species_29438", "WBGene00010374", "O45611", "WBGene00010374", "Q9XVQ7", "WBGene00008711", "O45657", "WBGene00004048", "U4PRY7", "WBGene00004047", "Q17330", "WBGene00004889", "Q95XP4", "WBGene00003111", "Q9TYS4", "WBGene00004890", "species_29438" ] }, "reaction_10521550": { "compartment": "compartment_70101", "id": "reaction_10521550", "reactome": "R-CEL-400682", "name": "Active Rac1 interacts with Plexin-B1:Sema4D", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10521546", "species_10509457" ], "products": [ "species_10521548" ], "modifiers": [], "additional_components": [ "Q9XVQ7", "WBGene00008711", "O45657", "WBGene00004048", "U4PRY7", "WBGene00004047", "Q17330", "WBGene00004889", "Q95XP4", "WBGene00003111", "Q9TYS4", "WBGene00004890", "species_29438", "Q03206", "ced-10", "species_29438", "Q03206", "ced-10", "Q9XVQ7", "WBGene00008711", "O45657", "WBGene00004048", "U4PRY7", "WBGene00004047", "Q17330", "WBGene00004889", "Q95XP4", "WBGene00003111", "Q9TYS4", "WBGene00004890" ] }, "reaction_10518688": { "compartment": "compartment_876", "id": "reaction_10518688", "reactome": "R-CEL-374663", "name": "DCC interaction with Ezrin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10518684", "species_10518486" ], "products": [ "species_10518686" ], "modifiers": [], "additional_components": [ "species_179856", "G5EBK3", "WBGene00001333", "G5EF96", "phospho-unc-40", "species_179856", "G5EBK3", "WBGene00001333" ] }, "reaction_10518706": { "compartment": "compartment_70101", "id": "reaction_10518706", "reactome": "R-CEL-374667", "name": "DCC interaction with SIAH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10518702", "species_10518499" ], "products": [ "species_10518704" ], "modifiers": [], "additional_components": [ "WBGene00021369", "P34710", "unc-6", "G5EF96", "phospho-unc-40", "P34710", "unc-6", "G5EF96", "phospho-unc-40", "Q965X6", "WBGene00021369" ] }, "reaction_10518691": { "compartment": "compartment_70101", "id": "reaction_10518691", "reactome": "R-CEL-374664", "name": "Phosphorylation and activation of Ezrin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10518677" ], "products": [ "species_10518684", "species_29370" ], "modifiers": [ [ "species_10515209", "catalyst" ] ], "additional_components": [ "species_179856", "G5EBK3", "WBGene00001333", "species_179856", "G5EBK3", "WBGene00001333", "WBGene00006599" ] }, "reaction_10518533": { "compartment": "compartment_70101", "id": "reaction_10518533", "reactome": "R-CEL-373716", "name": "DCC interacting NCK-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10518510", "species_10518529" ], "products": [ "species_10518531" ], "modifiers": [], "additional_components": [ "WBGene00006410", "P34710", "unc-6", "G5EF96", "phospho-unc-40", "Q95YD4", "WBGene00002213", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "P34710", "unc-6", "G5EF96", "phospho-unc-40", "Q95YD4", "WBGene00002213", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q95PX0", "WBGene00006410" ] }, "reaction_10521893": { "compartment": "compartment_70101", "id": "reaction_10521893", "reactome": "R-CEL-418850", "name": "Activation of Cdc42", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10520579", "species_10521888" ], "products": [ "species_29420", "species_10521890" ], "modifiers": [ [ "species_10521888", "catalyst" ] ], "additional_components": [ "Q05062", "WBGene00000390", "species_29420", "P34710", "unc-6", "G5EF96", "phospho-unc-40", "Q95YD4", "WBGene00002213", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q95PX0", "WBGene00006410", "G5EEN3", "WBGene00000419", "P34710", "unc-6", "G5EF96", "phospho-unc-40", "Q95YD4", "WBGene00002213", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q95PX0", "WBGene00006410", "G5EEN3", "WBGene00000419", "Q05062", "WBGene00000390", "species_29438", "P34710", "unc-6", "G5EF96", "phospho-unc-40", "Q95YD4", "WBGene00002213", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q95PX0", "WBGene00006410", "G5EEN3", "WBGene00000419" ] }, "reaction_10518503": { "compartment": "compartment_876", "id": "reaction_10518503", "reactome": "R-CEL-373707", "name": "Netrin-1 induced DCC clustering", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10518486", "species_10518499" ], "products": [ "species_10518501" ], "modifiers": [], "additional_components": [ "P34710", "unc-6", "G5EF96", "phospho-unc-40", "P34710", "unc-6", "G5EF96", "phospho-unc-40" ] }, "reaction_10518505": { "compartment": "compartment_984", "id": "reaction_10518505", "reactome": "R-CEL-373711", "name": "DCC interaction with Netrin-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10518486", "species_10518497" ], "products": [ "species_10518499" ], "modifiers": [], "additional_components": [ "P34710", "unc-6", "G5EF96", "phospho-unc-40" ] }, "reaction_10521899": { "compartment": "compartment_70101", "id": "reaction_10521899", "reactome": "R-CEL-418858", "name": "RhoGTPase GEF's recruited to DCC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10521886", "species_10518531" ], "products": [ "species_10521888" ], "modifiers": [], "additional_components": [ "WBGene00000419", "P34710", "unc-6", "G5EF96", "phospho-unc-40", "Q95YD4", "WBGene00002213", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q95PX0", "WBGene00006410", "P34710", "unc-6", "G5EF96", "phospho-unc-40", "Q95YD4", "WBGene00002213", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q95PX0", "WBGene00006410", "G5EEN3", "WBGene00000419" ] }, "reaction_10521901": { "compartment": "compartment_70101", "id": "reaction_10521901", "reactome": "R-CEL-418868", "name": "Recruitment of Src and Fyn to DCC:FADK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10518527", "species_10518770" ], "products": [ "species_10518772" ], "modifiers": [], "additional_components": [ "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "P34710", "unc-6", "G5EF96", "phospho-unc-40", "Q95YD4", "WBGene00002213", "P34710", "unc-6", "G5EF96", "phospho-unc-40", "Q95YD4", "WBGene00002213", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635" ] }, "reaction_10518781": { "compartment": "compartment_70101", "id": "reaction_10518781", "reactome": "R-CEL-374701", "name": "Phosphorylation of DCC by Fyn", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10518772" ], "products": [ "species_29370", "species_10518529" ], "modifiers": [ [ "species_10518772", "catalyst" ] ], "additional_components": [ "P34710", "unc-6", "G5EF96", "phospho-unc-40", "Q95YD4", "WBGene00002213", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "P34710", "unc-6", "G5EF96", "phospho-unc-40", "Q95YD4", "WBGene00002213", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "P34710", "unc-6", "G5EF96", "phospho-unc-40", "Q95YD4", "WBGene00002213", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635" ] }, "reaction_10519264": { "compartment": "compartment_876", "id": "reaction_10519264", "reactome": "R-CEL-376122", "name": "DSCAM/DSCAML1 homodimerization", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10519260" ], "products": [ "species_10519262" ], "modifiers": [], "additional_components": [ "Q18806", "WBGene00004370", "H2KZ60", "WBGene00016354", "Q18806", "WBGene00004370", "H2KZ60", "WBGene00016354" ] }, "reaction_10526129": { "compartment": "compartment_70101", "id": "reaction_10526129", "reactome": "R-CEL-451347", "name": "Activation of JNK by DSCAM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10510931" ], "products": [ "species_29370", "species_10510951" ], "modifiers": [ [ "species_10519282", "catalyst" ] ], "additional_components": [ "WBGene00002178", "WBGene00002178", "species_29438", "Q03206", "ced-10", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "Q18806", "WBGene00004370", "H2KZ60", "WBGene00016354" ] }, "reaction_10519284": { "compartment": "compartment_70101", "id": "reaction_10519284", "reactome": "R-CEL-376123", "name": "DSCAM associates with Rac1-GTP:pPAK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10519252", "species_10519280" ], "products": [ "species_10519282" ], "modifiers": [], "additional_components": [ "Q18806", "WBGene00004370", "H2KZ60", "WBGene00016354", "species_29438", "Q03206", "ced-10", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "species_29438", "Q03206", "ced-10", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "Q18806", "WBGene00004370", "H2KZ60", "WBGene00016354" ] }, "reaction_10526154": { "compartment": "compartment_70101", "id": "reaction_10526154", "reactome": "R-CEL-451366", "name": "Activation of p38MAPK by DSCAM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10526151" ], "products": [ "species_29370", "species_10512658" ], "modifiers": [ [ "species_10519282", "catalyst" ] ], "additional_components": [ "Q17446", "WBGene00004055", "Q8MXI4", "WBGene00004056", "species_114632", "Q17446", "WBGene00004055", "Q8MXI4", "WBGene00004056", "species_114632", "species_29438", "Q03206", "ced-10", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "Q18806", "WBGene00004370", "H2KZ60", "WBGene00016354" ] }, "reaction_10518679": { "compartment": "compartment_70101", "id": "reaction_10518679", "reactome": "R-CEL-374662", "name": "Translocation of Ezrin to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10518675", "species_179856" ], "products": [ "species_10518677" ], "modifiers": [], "additional_components": [ "WBGene00001333", "species_179856", "G5EBK3", "WBGene00001333" ] }, "reaction_10527529": { "compartment": "compartment_876", "id": "reaction_10527529", "reactome": "R-CEL-593685", "name": "Netrin-4 binds DCC/UNC5A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10527518", "species_10527525" ], "products": [ "species_10527527" ], "modifiers": [], "additional_components": [ "WBGene00002247", "Q26261", "WBGene00006745", "G5EF96", "phospho-unc-40", "Q26261", "WBGene00006745", "G5EF96", "phospho-unc-40", "O44565", "WBGene00002247" ] }, "reaction_10518700": { "compartment": "compartment_70101", "id": "reaction_10518700", "reactome": "R-CEL-374665", "name": "DCC interaction with SIAH1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10518696", "species_10518499" ], "products": [ "species_10518698" ], "modifiers": [], "additional_components": [ "WBGene00021369", "P34710", "unc-6", "G5EF96", "phospho-unc-40", "P34710", "unc-6", "G5EF96", "phospho-unc-40", "Q965X6", "WBGene00021369" ] }, "reaction_10518727": { "compartment": "compartment_70101", "id": "reaction_10518727", "reactome": "R-CEL-374673", "name": "L1 binds RanBPM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10518718", "species_10518723" ], "products": [ "species_10518725" ], "modifiers": [], "additional_components": [ "Q21465", "WBGene00019727", "Q5WRR1", "WBGene00006942", "WBGene00013202", "Q9XWK4", "WBGene00013202", "Q21465", "WBGene00019727", "Q5WRR1", "WBGene00006942" ] }, "reaction_10518546": { "compartment": "compartment_876", "id": "reaction_10518546", "reactome": "R-CEL-373730", "name": "Neurofascin and NrCAM heterodimerization", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10518542", "species_10518540" ], "products": [ "species_10518544" ], "modifiers": [], "additional_components": [ "WBGene00004732", "WBGene00004732", "Q53U87", "WBGene00004732" ] }, "reaction_10515214": { "compartment": "compartment_876", "id": "reaction_10515214", "reactome": "R-CEL-202222", "name": "Phosphorylation of PKC theta", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10515204" ], "products": [ "species_10515211", "species_29370" ], "modifiers": [ [ "species_10515195", "catalyst" ] ], "additional_components": [ "P34722", "WBGene00006599", "species_112275", "species_112275", "P34722", "WBGene00006599", "Q9UA62", "WBGene00021022", "species_202247", "species_179838" ] }, "reaction_10508214": { "compartment": "compartment_5460", "id": "reaction_10508214", "reactome": "R-CEL-77271", "name": "3-Oxotetradecanoyl-CoA+CoA-SH<=>Lauroyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_77269" ], "products": [ "species_77261", "species_113559" ], "modifiers": [ [ "species_10508211", "catalyst" ] ], "additional_components": [ "P34255", "WBGene00015125", "Q9GYT0", "WBGene00020347" ] }, "reaction_10508217": { "compartment": "compartment_5460", "id": "reaction_10508217", "reactome": "R-CEL-77277", "name": "trans-Tetradec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxytetradecanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77273", "species_113521" ], "products": [ "species_77276" ], "modifiers": [ [ "species_10508211", "catalyst" ] ], "additional_components": [ "P34255", "WBGene00015125", "Q9GYT0", "WBGene00020347" ] }, "reaction_10508220": { "compartment": "compartment_5460", "id": "reaction_10508220", "reactome": "R-CEL-77283", "name": "(S)-3-Hydroxytetradecanoyl-CoA+NAD<=>3-Oxotetradecanoyl-CoA+NADH+H", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77276", "species_113526" ], "products": [ "species_113529", "species_77269", "species_29362" ], "modifiers": [ [ "species_10508211", "catalyst" ] ], "additional_components": [ "P34255", "WBGene00015125", "Q9GYT0", "WBGene00020347" ] }, "reaction_10510256": { "compartment": "compartment_70101", "id": "reaction_10510256", "reactome": "R-CEL-163764", "name": "D-fructose 6-phosphate + D-erythrose 4-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29512", "species_29878" ], "products": [ "species_29578", "species_29882" ], "modifiers": [ [ "species_10503949", "catalyst" ] ], "additional_components": [ "Q966C7", "WBGene00021286" ] }, "reaction_10510242": { "compartment": "compartment_70101", "id": "reaction_10510242", "reactome": "R-CEL-163741", "name": "D-glyceraldehyde 3-phosphate + sedoheptulose 7-phosphate<=> xylulose 5-phosphate+ribose 5-phosphate ", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29882", "species_29578" ], "products": [ "species_29790", "species_73578" ], "modifiers": [ [ "species_10503939", "catalyst" ] ], "additional_components": [ "O17759", "WBGene00008506", "species_114632", "species_8878387" ] }, "reaction_10510252": { "compartment": "compartment_70101", "id": "reaction_10510252", "reactome": "R-CEL-163751", "name": "D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate <=> xylulose 5-phosphate + D-erythrose 4-phosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29578", "species_29512" ], "products": [ "species_29790", "species_29878" ], "modifiers": [ [ "species_10503939", "catalyst" ] ], "additional_components": [ "O17759", "WBGene00008506", "species_114632", "species_8878387" ] }, "reaction_10513329": { "compartment": "compartment_984", "id": "reaction_10513329", "reactome": "R-CEL-192417", "name": "Digestion of cholesterol esters by extracellular CEL (bile salt-dependent lipase)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_171076" ], "products": [ "species_171149", "species_174602" ], "modifiers": [ [ "species_10513326", "catalyst" ] ], "additional_components": [ "CHEBI:17687", "CHEBI:28865", "CHEBI:16755", "CHEBI:36274", "species_193451", "CHEBI:9407", "Q20826", "WBGene00018878", "Q9XTG1", "WBGene00006412" ] }, "reaction_10513332": { "compartment": "compartment_984", "id": "reaction_10513332", "reactome": "R-CEL-192425", "name": "Digestion of monoacylglycerols by extracellular CEL (bile salt-dependent lipase)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_6814795" ], "products": [ "species_174602", "species_192438" ], "modifiers": [ [ "species_10513326", "catalyst" ] ], "additional_components": [ "CHEBI:17687", "CHEBI:28865", "CHEBI:16755", "CHEBI:36274", "species_193451", "CHEBI:9407", "Q20826", "WBGene00018878", "Q9XTG1", "WBGene00006412" ] }, "reaction_10513334": { "compartment": "compartment_984", "id": "reaction_10513334", "reactome": "R-CEL-192430", "name": "Digestion of triacylglycerols by extracellular CEL (bile salt-dependent lipase)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_171126" ], "products": [ "species_174602", "species_174675" ], "modifiers": [ [ "species_10513326", "catalyst" ] ], "additional_components": [ "CHEBI:17687", "CHEBI:28865", "CHEBI:16755", "CHEBI:36274", "species_193451", "CHEBI:9407", "Q20826", "WBGene00018878", "Q9XTG1", "WBGene00006412" ] }, "reaction_10570265": { "compartment": "compartment_984", "id": "reaction_10570265", "reactome": "R-CEL-8979996", "name": "LIPs hydrolyze TG to DAG and LCFA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_171126" ], "products": [ "species_174602", "species_174675" ], "modifiers": [ [ "species_10570262", "catalyst" ] ], "additional_components": [] }, "reaction_10554517": { "compartment": "compartment_70101", "id": "reaction_10554517", "reactome": "R-CEL-5661256", "name": "AKR1A1 reduces D-glucuronate to L-gulonate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_5661264", "species_29364" ], "products": [ "species_29366", "species_5661268" ], "modifiers": [ [ "species_10554514", "catalyst" ] ], "additional_components": [ "WBGene00012722" ] }, "reaction_10554535": { "compartment": "compartment_70101", "id": "reaction_10554535", "reactome": "R-CEL-5662466", "name": "XYLB phosphorylates D-xylulose", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_5661281" ], "products": [ "species_29790", "species_29370" ], "modifiers": [ [ "species_10554532", "catalyst" ] ], "additional_components": [ "WBGene00011147" ] }, "reaction_10554538": { "compartment": "compartment_70101", "id": "reaction_10554538", "reactome": "R-CEL-5662471", "name": "SORD tetramer oxidizes xylitol to D-xylulose", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5660033", "species_29360" ], "products": [ "species_70106", "species_5661281", "species_73473" ], "modifiers": [ [ "species_10554251", "catalyst" ] ], "additional_components": [ "species_216785", "Q21702", "WBGene00011003" ] }, "reaction_10554509": { "compartment": "compartment_70101", "id": "reaction_10554509", "reactome": "R-CEL-5661240", "name": "DCXR tetramer reduces L-xylulose to xylitol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_5660036" ], "products": [ "species_5660033", "species_29366" ], "modifiers": [ [ "species_10554506", "catalyst" ] ], "additional_components": [ "Q21929", "WBGene00000984" ] }, "reaction_10554527": { "compartment": "compartment_70101", "id": "reaction_10554527", "reactome": "R-CEL-5661290", "name": "CRYL1 dimer dehydrogenates L-gulonate to 3-dehydro-L-gulonate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5661268", "species_29360" ], "products": [ "species_70106", "species_5661262", "species_73473" ], "modifiers": [ [ "species_10554524", "catalyst" ] ], "additional_components": [ "C0VXV5", "WBGene00022130" ] }, "reaction_10543520": { "compartment": "compartment_984", "id": "reaction_10543520", "reactome": "R-CEL-2213201", "name": "Formation of collagen fibres", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10534604" ], "products": [ "species_10543518" ], "modifiers": [], "additional_components": [ "Q9N4U2", "WBGene00000647", "O76368", "WBGene00000674", "Q09457", "WBGene00000251", "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689", "P17140", "WBGene00002280", "Q21437", "WBGene00000659", "Q9N4U2", "WBGene00000647", "O76368", "WBGene00000674", "Q09457", "WBGene00000251", "P17140", "WBGene00002280", "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689", "Q21437", "WBGene00000659" ] }, "reaction_10543796": { "compartment": "compartment_984", "id": "reaction_10543796", "reactome": "R-CEL-2299620", "name": "Collagen XI cross-links with collagen II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10517286", "species_10534598" ], "products": [ "species_10543794" ], "modifiers": [], "additional_components": [ "O76368", "WBGene00000674", "Q09457", "WBGene00000251", "Q9N4U2", "WBGene00000647", "O76368", "WBGene00000674", "Q09457", "WBGene00000251", "Q9N4U2", "WBGene00000647", "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689", "O76368", "WBGene00000674", "Q09457", "WBGene00000251", "Q9N4U2", "WBGene00000647", "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689" ] }, "reaction_10543528": { "compartment": "compartment_984", "id": "reaction_10543528", "reactome": "R-CEL-2213207", "name": "Formation of collagen networks", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10543522" ], "products": [ "species_10543526" ], "modifiers": [], "additional_components": [ "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689", "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689" ] }, "reaction_10544002": { "compartment": "compartment_984", "id": "reaction_10544002", "reactome": "R-CEL-2395223", "name": "Formation of hydroxylysyl-pyridinoline cross-links", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10543979" ], "products": [ "species_10544000" ], "modifiers": [], "additional_components": [ "Q9N4U2", "WBGene00000647", "Q9N4U2", "WBGene00000647" ] }, "reaction_10544004": { "compartment": "compartment_984", "id": "reaction_10544004", "reactome": "R-CEL-2395257", "name": "Formation of dehydro-hydroxylysino-norleucine cross-links", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10540843", "species_10509625" ], "products": [ "species_10543638" ], "modifiers": [], "additional_components": [ "Q9N4U2", "WBGene00000647", "Q9N4U2", "WBGene00000647", "Q9N4U2", "WBGene00000647" ] }, "reaction_10543701": { "compartment": "compartment_984", "id": "reaction_10543701", "reactome": "R-CEL-2243931", "name": "Formation of dehydro-lysinonorleucine cross-links", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10540843", "species_10509625" ], "products": [ "species_10543699" ], "modifiers": [], "additional_components": [ "Q9N4U2", "WBGene00000647", "Q9N4U2", "WBGene00000647", "Q9N4U2", "WBGene00000647" ] }, "reaction_10544086": { "compartment": "compartment_984", "id": "reaction_10544086", "reactome": "R-CEL-2395324", "name": "Formation of hydroxylysyl-pyrrole cross-links", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10543979", "species_10543638" ], "products": [ "species_10544084" ], "modifiers": [], "additional_components": [ "Q9N4U2", "WBGene00000647", "Q9N4U2", "WBGene00000647", "Q9N4U2", "WBGene00000647" ] }, "reaction_10544024": { "compartment": "compartment_984", "id": "reaction_10544024", "reactome": "R-CEL-2395302", "name": "Formation of hydroxylysino-5-ketonorleucine cross-links", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509625", "species_10544022" ], "products": [ "species_10543979" ], "modifiers": [], "additional_components": [ "Q9N4U2", "WBGene00000647", "Q9N4U2", "WBGene00000647", "Q9N4U2", "WBGene00000647" ] }, "reaction_10544026": { "compartment": "compartment_984", "id": "reaction_10544026", "reactome": "R-CEL-2395314", "name": "Formation of lysino-5-ketonorleucine cross-links", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509625", "species_10544022" ], "products": [ "species_10543730" ], "modifiers": [], "additional_components": [ "Q9N4U2", "WBGene00000647", "Q9N4U2", "WBGene00000647", "Q9N4U2", "WBGene00000647" ] }, "reaction_10543754": { "compartment": "compartment_984", "id": "reaction_10543754", "reactome": "R-CEL-2250301", "name": "Formation of lysyl-pyrrole cross-links", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10543638", "species_10543730" ], "products": [ "species_10543752" ], "modifiers": [], "additional_components": [ "Q9N4U2", "WBGene00000647", "Q9N4U2", "WBGene00000647", "Q9N4U2", "WBGene00000647" ] }, "reaction_10543642": { "compartment": "compartment_984", "id": "reaction_10543642", "reactome": "R-CEL-2243926", "name": "Formation of histidino-hydroxylysinonorleucine cross-links", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509625", "species_10543638" ], "products": [ "species_10543640" ], "modifiers": [], "additional_components": [ "Q9N4U2", "WBGene00000647", "Q9N4U2", "WBGene00000647", "Q9N4U2", "WBGene00000647" ] }, "reaction_10544063": { "compartment": "compartment_984", "id": "reaction_10544063", "reactome": "R-CEL-2395322", "name": "Formation of lysyl-pyridinoline cross-links", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10543979", "species_10543730" ], "products": [ "species_10544061" ], "modifiers": [], "additional_components": [ "Q9N4U2", "WBGene00000647", "Q9N4U2", "WBGene00000647", "Q9N4U2", "WBGene00000647" ] }, "reaction_10543532": { "compartment": "compartment_984", "id": "reaction_10543532", "reactome": "R-CEL-2213208", "name": "Type X collagen associates with collagen type II fibrils", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10517286", "species_10543524" ], "products": [ "species_10543530" ], "modifiers": [], "additional_components": [ "O76368", "WBGene00000674", "Q09457", "WBGene00000251", "Q9N4U2", "WBGene00000647", "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689", "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689", "O76368", "WBGene00000674", "Q09457", "WBGene00000251", "Q9N4U2", "WBGene00000647" ] }, "reaction_10534606": { "compartment": "compartment_984", "id": "reaction_10534606", "reactome": "R-CEL-1474266", "name": "Formation of collagen fibrils", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10534596" ], "products": [ "species_10534604" ], "modifiers": [], "additional_components": [ "P17140", "WBGene00002280", "O76368", "WBGene00000674", "Q09457", "WBGene00000251", "Q9N4U2", "WBGene00000647", "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689", "Q21437", "WBGene00000659", "Q9N4U2", "WBGene00000647", "O76368", "WBGene00000674", "Q09457", "WBGene00000251", "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689", "P17140", "WBGene00002280", "Q21437", "WBGene00000659" ] }, "reaction_10556034": { "compartment": "compartment_5460", "id": "reaction_10556034", "reactome": "R-CEL-5688276", "name": "SIRT4 transfers ADPRib to GLUD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10503183", "species_113526" ], "products": [ "species_10556024", "species_5688274" ], "modifiers": [ [ "species_10556031", "catalyst" ] ], "additional_components": [ "WBGene00014095", "WBGene00014095", "Q20480", "WBGene00004801", "species_216785" ] }, "reaction_10573249": { "compartment": "compartment_70101", "id": "reaction_10573249", "reactome": "R-CEL-9698844", "name": "MLKL binds HSP90:CDC37", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10550681", "species_10538179", "species_10538177" ], "products": [ "species_10573247" ], "modifiers": [], "additional_components": [ "WBGene00003030", "Q18688", "WBGene00000915", "O02108", "WBGene00021097", "O02108", "WBGene00021097", "Q18688", "WBGene00000915", "Q07292", "WBGene00003030" ] }, "reaction_10505687": { "compartment": "compartment_70101", "id": "reaction_10505687", "reactome": "R-CEL-72621", "name": "Ribosomal scanning ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10505676", "species_113592" ], "products": [ "species_29372", "species_10505676", "species_29370" ], "modifiers": [ [ "species_72617", "catalyst" ], [ "species_113592", "catalyst" ] ], "additional_components": [ "A0A486WX07", "WBGene00002066", "Q20935", "WBGene00018997", "P27639", "WBGene00002083", "O61955", "WBGene00002061", "species_29438", "Q9BKU3", "WBGene00021351", "Q21230", "WBGene00010560", "Q95XR0", "WBGene00021466", "P51403", "WBGene00004471", "Q9NEN6", "WBGene00004475", "Q8WQA8", "WBGene00004489", "Q23312", "WBGene00004476", "O01869", "WBGene00004479", "P49197", "WBGene00004490", "P48156", "WBGene00004477", "Q20206", "WBGene00004480", "Q19877", "WBGene00004492", "Q20228", "WBGene00004478", "P49196", "WBGene00004481", "Q1XFY9", "WBGene00004493", "P46769", "WBGene00004469", "P51404", "WBGene00004482", "P52821", "WBGene00004494", "Q9TXP0", "WBGene00004496", "P48150", "WBGene00004483", "O45499", "WBGene00004495", "Q9N3X2", "WBGene00004473", "Q9XVP0", "WBGene00004484", "Q95Y04", "WBGene00004497", "Q22054", "WBGene00004485", "P90983", "WBGene00004498", "O01692", "WBGene00004486", "P48152", "WBGene00004472", "O18240", "WBGene00004487", "O18650", "WBGene00004488", "P48154", "WBGene00004470", "O17218", "WBGene00004491", "P49041", "WBGene00004474", "Q95QW0", "WBGene00015920", "O01974", "WBGene00001231", "Q94261", "WBGene00019543", "P34339", "WBGene00001209", "Q9XWP7", "WBGene00012738", "P30642", "WBGene00001227", "Q965S8", "WBGene00001232", "O02328", "WBGene00001226", "Q19706", "WBGene00001230", "O61820", "WBGene00001228", "Q18967", "WBGene00001229", "Q9XUP3", "WBGene00001233", "Q9XWI6", "WBGene00001225", "Q9TXU7", "WBGene00019162", "H2L0A8", "WBGene00019157", "A0A486WX07", "WBGene00002066", "Q20935", "WBGene00018997", "P27639", "WBGene00002083", "O61955", "WBGene00002061", "species_29438", "Q9BKU3", "WBGene00021351", "Q21230", "WBGene00010560", "Q95XR0", "WBGene00021466", "P51403", "WBGene00004471", "Q9NEN6", "WBGene00004475", "Q8WQA8", "WBGene00004489", "Q23312", "WBGene00004476", "O01869", "WBGene00004479", "P49197", "WBGene00004490", "P48156", "WBGene00004477", "Q20206", "WBGene00004480", "Q19877", "WBGene00004492", "Q20228", "WBGene00004478", "P49196", "WBGene00004481", "Q1XFY9", "WBGene00004493", "P46769", "WBGene00004469", "P51404", "WBGene00004482", "P52821", "WBGene00004494", "Q9TXP0", "WBGene00004496", "P48150", "WBGene00004483", "O45499", "WBGene00004495", "Q9N3X2", "WBGene00004473", "Q9XVP0", "WBGene00004484", "Q95Y04", "WBGene00004497", "Q22054", "WBGene00004485", "P90983", "WBGene00004498", "O01692", "WBGene00004486", "P48152", "WBGene00004472", "O18240", "WBGene00004487", "O18650", "WBGene00004488", "P48154", "WBGene00004470", "O17218", "WBGene00004491", "P49041", "WBGene00004474", "Q95QW0", "WBGene00015920", "O01974", "WBGene00001231", "Q94261", "WBGene00019543", "P34339", "WBGene00001209", "Q9XWP7", "WBGene00012738", "P30642", "WBGene00001227", "Q965S8", "WBGene00001232", "O02328", "WBGene00001226", "Q19706", "WBGene00001230", "O61820", "WBGene00001228", "Q18967", "WBGene00001229", "Q9XUP3", "WBGene00001233", "Q9XWI6", "WBGene00001225", "Q9TXU7", "WBGene00019162", "H2L0A8", "WBGene00019157" ] }, "reaction_10505999": { "compartment": "compartment_70101", "id": "reaction_10505999", "reactome": "R-CEL-72697", "name": "Start codon recognition", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10505631", "species_10505614", "species_10505676", "species_72617", "species_10505681" ], "products": [ "species_10505631", "species_10505614", "species_10505676", "species_72617", "species_10505681" ], "modifiers": [ [ "species_72617", "catalyst" ] ], "additional_components": [ "Q9BKU3", "WBGene00021351", "Q21230", "WBGene00010560", "Q95XR0", "WBGene00021466", "WBGene00019162", "A0A486WX07", "WBGene00002066", "Q20935", "WBGene00018997", "P27639", "WBGene00002083", "O61955", "WBGene00002061", "species_29438", "Q9BKU3", "WBGene00021351", "Q21230", "WBGene00010560", "Q95XR0", "WBGene00021466", "P51403", "WBGene00004471", "Q9NEN6", "WBGene00004475", "Q8WQA8", "WBGene00004489", "Q23312", "WBGene00004476", "O01869", "WBGene00004479", "P49197", "WBGene00004490", "P48156", "WBGene00004477", "Q20206", "WBGene00004480", "Q19877", "WBGene00004492", "Q20228", "WBGene00004478", "P49196", "WBGene00004481", "Q1XFY9", "WBGene00004493", "P46769", "WBGene00004469", "P51404", "WBGene00004482", "P52821", "WBGene00004494", "Q9TXP0", "WBGene00004496", "P48150", "WBGene00004483", "O45499", "WBGene00004495", "Q9N3X2", "WBGene00004473", "Q9XVP0", "WBGene00004484", "Q95Y04", "WBGene00004497", "Q22054", "WBGene00004485", "P90983", "WBGene00004498", "O01692", "WBGene00004486", "P48152", "WBGene00004472", "O18240", "WBGene00004487", "O18650", "WBGene00004488", "P48154", "WBGene00004470", "O17218", "WBGene00004491", "P49041", "WBGene00004474", "Q95QW0", "WBGene00015920", "O01974", "WBGene00001231", "Q94261", "WBGene00019543", "P34339", "WBGene00001209", "Q9XWP7", "WBGene00012738", "P30642", "WBGene00001227", "Q965S8", "WBGene00001232", "O02328", "WBGene00001226", "Q19706", "WBGene00001230", "O61820", "WBGene00001228", "Q18967", "WBGene00001229", "Q9XUP3", "WBGene00001233", "Q9XWI6", "WBGene00001225", "Q9TXU7", "WBGene00019162", "H2L0A8", "WBGene00019157", "WBGene00016496", "Q9BKU3", "WBGene00021351", "Q21230", "WBGene00010560", "Q95XR0", "WBGene00021466", "WBGene00019162", "A0A486WX07", "WBGene00002066", "Q20935", "WBGene00018997", "P27639", "WBGene00002083", "O61955", "WBGene00002061", "species_29438", "Q9BKU3", "WBGene00021351", "Q21230", "WBGene00010560", "Q95XR0", "WBGene00021466", "P51403", "WBGene00004471", "Q9NEN6", "WBGene00004475", "Q8WQA8", "WBGene00004489", "Q23312", "WBGene00004476", "O01869", "WBGene00004479", "P49197", "WBGene00004490", "P48156", "WBGene00004477", "Q20206", "WBGene00004480", "Q19877", "WBGene00004492", "Q20228", "WBGene00004478", "P49196", "WBGene00004481", "Q1XFY9", "WBGene00004493", "P46769", "WBGene00004469", "P51404", "WBGene00004482", "P52821", "WBGene00004494", "Q9TXP0", "WBGene00004496", "P48150", "WBGene00004483", "O45499", "WBGene00004495", "Q9N3X2", "WBGene00004473", "Q9XVP0", "WBGene00004484", "Q95Y04", "WBGene00004497", "Q22054", "WBGene00004485", "P90983", "WBGene00004498", "O01692", "WBGene00004486", "P48152", "WBGene00004472", "O18240", "WBGene00004487", "O18650", "WBGene00004488", "P48154", "WBGene00004470", "O17218", "WBGene00004491", "P49041", "WBGene00004474", "Q95QW0", "WBGene00015920", "O01974", "WBGene00001231", "Q94261", "WBGene00019543", "P34339", "WBGene00001209", "Q9XWP7", "WBGene00012738", "P30642", "WBGene00001227", "Q965S8", "WBGene00001232", "O02328", "WBGene00001226", "Q19706", "WBGene00001230", "O61820", "WBGene00001228", "Q18967", "WBGene00001229", "Q9XUP3", "WBGene00001233", "Q9XWI6", "WBGene00001225", "Q9TXU7", "WBGene00019162", "H2L0A8", "WBGene00019157", "WBGene00016496" ] }, "reaction_10567089": { "compartment": "compartment_70101", "id": "reaction_10567089", "reactome": "R-CEL-8870469", "name": "RGGT geranylgeranylates RAB proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1131164", "species_10566884" ], "products": [ "species_10567086", "species_10567084", "species_1132084" ], "modifiers": [ [ "species_10566884", "catalyst" ] ], "additional_components": [ "A0A2C9C2Y0", "WBGene00006833", "G5EBF0", "WBGene00011083", "Q94986", "WBGene00004267", "O01803", "WBGene00004274", "P91857", "WBGene00004268", "G5EFC1", "WBGene00004272", "Q21137", "WBGene00019317", "Q9UAQ6", "WBGene00004266", "species_29420", "Q9TYY0", "WBGene00019778", "P41992", "WBGene00015099", "Q9BKQ5", "WBGene00022051", "species_1131164", "Q9TYY0", "WBGene00019778", "P41992", "WBGene00015099", "species_1131164", "Q9BKQ5", "WBGene00022051", "G5EFC1", "WBGene00004272", "Q21137", "WBGene00019317", "A0A2C9C2Y0", "WBGene00006833", "O01803", "WBGene00004274", "Q94986", "WBGene00004267", "P91857", "WBGene00004268", "Q9UAQ6", "WBGene00004266", "G5EBF0", "WBGene00011083", "species_29420", "A0A2C9C2Y0", "WBGene00006833", "G5EBF0", "WBGene00011083", "Q94986", "WBGene00004267", "O01803", "WBGene00004274", "P91857", "WBGene00004268", "G5EFC1", "WBGene00004272", "Q21137", "WBGene00019317", "Q9UAQ6", "WBGene00004266", "species_29420", "Q9TYY0", "WBGene00019778", "P41992", "WBGene00015099", "Q9BKQ5", "WBGene00022051", "species_1131164" ] }, "reaction_10566886": { "compartment": "compartment_70101", "id": "reaction_10566886", "reactome": "R-CEL-8870466", "name": "RGGT:CHM binds RABs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10566765", "species_10566882" ], "products": [ "species_10566884" ], "modifiers": [], "additional_components": [ "Q9TYY0", "WBGene00019778", "P41992", "WBGene00015099", "Q9BKQ5", "WBGene00022051", "species_1131164", "A0A2C9C2Y0", "WBGene00006833", "G5EBF0", "WBGene00011083", "Q94986", "WBGene00004267", "O01803", "WBGene00004274", "P91857", "WBGene00004268", "G5EFC1", "WBGene00004272", "Q21137", "WBGene00019317", "Q9UAQ6", "WBGene00004266", "species_29420", "A0A2C9C2Y0", "WBGene00006833", "G5EBF0", "WBGene00011083", "Q94986", "WBGene00004267", "O01803", "WBGene00004274", "P91857", "WBGene00004268", "G5EFC1", "WBGene00004272", "Q21137", "WBGene00019317", "Q9UAQ6", "WBGene00004266", "species_29420", "Q9TYY0", "WBGene00019778", "P41992", "WBGene00015099", "Q9BKQ5", "WBGene00022051", "species_1131164" ] }, "reaction_10566761": { "compartment": "compartment_70101", "id": "reaction_10566761", "reactome": "R-CEL-8870461", "name": "RABGGTA and RABGGTB bind", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10566757", "species_10566755" ], "products": [ "species_10566759" ], "modifiers": [], "additional_components": [ "WBGene00015099", "WBGene00019778", "Q9TYY0", "WBGene00019778", "P41992", "WBGene00015099" ] }, "reaction_10566767": { "compartment": "compartment_70101", "id": "reaction_10566767", "reactome": "R-CEL-8870465", "name": "RGGT binds the RAB-binding subunit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1131164", "species_10562902", "species_10566759" ], "products": [ "species_10566765" ], "modifiers": [], "additional_components": [ "WBGene00022051", "Q9TYY0", "WBGene00019778", "P41992", "WBGene00015099", "Q9TYY0", "WBGene00019778", "P41992", "WBGene00015099", "Q9BKQ5", "WBGene00022051", "species_1131164" ] }, "reaction_10565410": { "compartment": "compartment_70101", "id": "reaction_10565410", "reactome": "R-CEL-8853379", "name": "ENGASE hydrolyses unfolded protein:(GlcNAc)2 (Man(9-5)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10531865" ], "products": [ "species_8853371", "species_8853381" ], "modifiers": [ [ "species_10565407", "catalyst" ] ], "additional_components": [ "CHEBI:60627", "CHEBI:60628", "species_915149", "CHEBI:60629", "species_964740", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "species_8853396", "CHEBI:91284", "CHEBI:91283", "CHEBI:91282", "CHEBI:91281", "WBGene00017164" ] }, "reaction_10565052": { "compartment": "compartment_70101", "id": "reaction_10565052", "reactome": "R-CEL-8850594", "name": "Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10531865" ], "products": [ "species_1022114", "species_8852852" ], "modifiers": [ [ "species_10565049", "catalyst" ] ], "additional_components": [ "CHEBI:60627", "CHEBI:60628", "species_915149", "CHEBI:60629", "species_964740", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "CHEBI:60628", "CHEBI:60629", "species_964740", "species_915149", "CHEBI:60627", "Q9TW67", "WBGene00010160", "Q9TXH9", "WBGene00017733", "Q23451", "WBGene00013924", "P90859", "WBGene00009164", "Q93561", "WBGene00000843", "P54812", "WBGene00008053", "O16368", "WBGene00004502" ] }, "reaction_10531867": { "compartment": "compartment_70101", "id": "reaction_10531867", "reactome": "R-CEL-1022127", "name": "Ub-unfolded protein:(GlcNAc)2 (Man)9-5 translocates from ERQC to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10531863" ], "products": [ "species_10531865" ], "modifiers": [], "additional_components": [ "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "CHEBI:60627", "CHEBI:60628", "species_915149", "CHEBI:60629", "species_964740", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727" ] }, "reaction_10528423": { "compartment": "compartment_17957", "id": "reaction_10528423", "reactome": "R-CEL-901047", "name": "Binding of ERp57", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10527333", "species_10528419" ], "products": [ "species_10528421" ], "modifiers": [], "additional_components": [ "WBGene00003964", "CHEBI:59080", "P34652", "WBGene00000567", "P27798", "WBGene00000802", "CHEBI:59080", "P34652", "WBGene00000567", "P27798", "WBGene00000802", "G5ED07", "WBGene00003964" ] }, "reaction_10529604": { "compartment": "compartment_20699", "id": "reaction_10529604", "reactome": "R-CEL-964768", "name": "Addition of GlcNAc to the glycan on the A arm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_914003", "species_964740" ], "products": [ "species_964837", "species_205687" ], "modifiers": [ [ "species_10529601", "catalyst" ] ], "additional_components": [ "WBGene00001638" ] }, "reaction_10530596": { "compartment": "compartment_20699", "id": "reaction_10530596", "reactome": "R-CEL-975916", "name": "Addition of GlcNAc to position 5 by MGAT5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_914003", "species_975910" ], "products": [ "species_981617" ], "modifiers": [ [ "species_10530593", "catalyst" ] ], "additional_components": [ "WBGene00001627" ] }, "reaction_10525152": { "compartment": "compartment_12045", "id": "reaction_10525152", "reactome": "R-CEL-446207", "name": "ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_162756", "species_449222" ], "products": [ "species_449293", "species_110096" ], "modifiers": [ [ "species_10525149", "catalyst" ] ], "additional_components": [ "P92012", "WBGene00011193", "U4PE03", "WBGene00019725" ] }, "reaction_10525186": { "compartment": "compartment_12045", "id": "reaction_10525186", "reactome": "R-CEL-446218", "name": "Addition of the first mannose to the N-glycan precursor by ALG1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_162860", "species_449293" ], "products": [ "species_29420", "species_449283" ], "modifiers": [ [ "species_10525183", "catalyst" ] ], "additional_components": [ "WBGene00020820" ] }, "reaction_10525074": { "compartment": "compartment_17957", "id": "reaction_10525074", "reactome": "R-CEL-446188", "name": "ALG3 transfers Man to N-glycan precursor (GlcNAc)2 (Man)5 (PP-Dol)1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449229", "species_449298" ], "products": [ "species_449311", "species_449315" ], "modifiers": [ [ "species_10525066", "catalyst" ], [ "species_10525072", "catalyst" ] ], "additional_components": [ "WBGene00010720", "WBGene00018181" ] }, "reaction_10525091": { "compartment": "compartment_12045", "id": "reaction_10525091", "reactome": "R-CEL-446191", "name": "Addition of N-acetyl-D-glucosamine to Dolichyl phosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_162756", "species_449299" ], "products": [ "species_109402", "species_449222" ], "modifiers": [ [ "species_10525088", "catalyst" ] ], "additional_components": [ "WBGene00013362" ] }, "reaction_10525107": { "compartment": "compartment_17957", "id": "reaction_10525107", "reactome": "R-CEL-446198", "name": "ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449229", "species_449312" ], "products": [ "species_449311", "species_449365" ], "modifiers": [ [ "species_10525104", "catalyst" ], [ "species_10525072", "catalyst" ] ], "additional_components": [ "WBGene00022629", "WBGene00018181" ] }, "reaction_10525127": { "compartment": "compartment_17957", "id": "reaction_10525127", "reactome": "R-CEL-446202", "name": "Addition of the first glucose to the N-glycan precursor by ALG6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449371", "species_532542" ], "products": [ "species_449311", "species_449649" ], "modifiers": [ [ "species_10525124", "catalyst" ] ], "additional_components": [ "WBGene00007435" ] }, "reaction_10525160": { "compartment": "compartment_12045", "id": "reaction_10525160", "reactome": "R-CEL-446208", "name": "Addition of a second mannose to the N-glycan precursor by ALG2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_162860", "species_449283" ], "products": [ "species_449737", "species_29420" ], "modifiers": [ [ "species_10525157", "catalyst" ] ], "additional_components": [ "WBGene00017282" ] }, "reaction_10525176": { "compartment": "compartment_17957", "id": "reaction_10525176", "reactome": "R-CEL-446215", "name": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)6 (PP-Dol)1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449229", "species_449315" ], "products": [ "species_449311", "species_449312" ], "modifiers": [ [ "species_10525173", "catalyst" ], [ "species_10525072", "catalyst" ] ], "additional_components": [ "WBGene00007556", "WBGene00018181" ] }, "reaction_10525178": { "compartment": "compartment_17957", "id": "reaction_10525178", "reactome": "R-CEL-446216", "name": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)8 (PP-Dol)1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449229", "species_449365" ], "products": [ "species_449371", "species_449311" ], "modifiers": [ [ "species_10525173", "catalyst" ], [ "species_10525072", "catalyst" ] ], "additional_components": [ "WBGene00007556", "WBGene00018181" ] }, "reaction_10525083": { "compartment": "compartment_17957", "id": "reaction_10525083", "reactome": "R-CEL-446189", "name": "Addition of a second glucose to the N-glycan precursor by ALG8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449649", "species_532542" ], "products": [ "species_449311", "species_449638" ], "modifiers": [ [ "species_10525080", "catalyst" ] ], "additional_components": [ "WBGene00007464" ] }, "reaction_10565708": { "compartment": "compartment_984", "id": "reaction_10565708", "reactome": "R-CEL-8855711", "name": "PALM-C36-ASGR1:PALM-C54,58-ASGR2 binds desialated glycoproteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8855720", "species_10565704" ], "products": [ "species_10565706" ], "modifiers": [], "additional_components": [ "O18076", "WBGene00011668", "Q9N4W4", "WBGene00021602", "O44871", "WBGene00019914", "Q9N4W5", "WBGene00021603", "P91214", "WBGene00017199", "Q21146", "WBGene00019328", "O18076", "WBGene00011668", "Q9N4W4", "WBGene00021602", "O44871", "WBGene00019914", "Q9N4W5", "WBGene00021603", "P91214", "WBGene00017199", "Q21146", "WBGene00019328", "species_8855720" ] }, "reaction_10510086": { "compartment": "compartment_17957", "id": "reaction_10510086", "reactome": "R-CEL-162683", "name": "glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_75967", "species_8855661" ], "products": [ "species_8855666", "species_76194" ], "modifiers": [ [ "species_10510083", "catalyst" ] ], "additional_components": [ "WBGene00022447" ] }, "reaction_10510118": { "compartment": "compartment_12045", "id": "reaction_10510118", "reactome": "R-CEL-162873", "name": "(ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449229", "species_8855663" ], "products": [ "species_162872", "species_8855667" ], "modifiers": [ [ "species_10510115", "catalyst" ] ], "additional_components": [ "WBGene00020375" ] }, "reaction_10510102": { "compartment": "compartment_12045", "id": "reaction_10510102", "reactome": "R-CEL-162821", "name": "mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449229", "species_8855667" ], "products": [ "species_8855656", "species_162872" ], "modifiers": [ [ "species_10510099", "catalyst" ] ], "additional_components": [ "WBGene00194986" ] }, "reaction_10510110": { "compartment": "compartment_70101", "id": "reaction_10510110", "reactome": "R-CEL-162857", "name": "N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8855657", "species_29356" ], "products": [ "species_8855661", "species_29416" ], "modifiers": [ [ "species_10510107", "catalyst" ] ], "additional_components": [ "WBGene00013131" ] }, "reaction_10510094": { "compartment": "compartment_12045", "id": "reaction_10510094", "reactome": "R-CEL-162798", "name": "mannose(a1-4)glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose(al1-4)glucosaminyl-acyl-PI + diacylglycerol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8855659", "species_1500581" ], "products": [ "species_8855663", "species_1500596" ], "modifiers": [ [ "species_10510091", "catalyst" ] ], "additional_components": [ "WBGene00021840" ] }, "reaction_10569975": { "compartment": "compartment_70101", "id": "reaction_10569975", "reactome": "R-CEL-8955241", "name": "CAND1 binds cytosolic CRL E3 ubiquitin ligases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10556809", "species_10569971" ], "products": [ "species_10569973" ], "modifiers": [], "additional_components": [ "WBGene00013606", "G5ECR7", "WBGene00001235", "Q23457", "WBGene00004320", "Q17390", "WBGene00000837", "Q19213", "WBGene00006922", "P17221", "WBGene00001411", "Q9BKS1", "WBGene00001236", "O61795", "WBGene00020030", "Q20183", "WBGene00006415", "A0PD34", "WBGene00014848", "O62200", "WBGene00014848", "Q03607", "WBGene00014848", "G5ED84", "WBGene00020952", "Q21854", "WBGene00006493", "G5EGS4", "WBGene00002184", "Q17391", "WBGene00000838", "Q94251", "WBGene00001089", "Q17531", "WBGene00007206", "Q17962", "WBGene00007574", "O17324", "WBGene00015673", "Q20367", "WBGene00005013", "Q9GYI0", "WBGene00017920", "O45323", "WBGene00008439", "P34284", "WBGene00015350", "Q6A590", "WBGene00020884", "G5EES6", "WBGene00007333", "Q9N3G1", "WBGene00021815", "Q22071", "WBGene00003177", "G5ECU1", "WBGene00004807", "Q17389", "WBGene00000836", "Q93349", "WBGene00007985", "O45498", "WBGene00009556", "Q965N7", "WBGene00021596", "Q965N6", "WBGene00021597", "G5EFS1", "WBGene00002069", "Q9BL53", "WBGene00022139", "Q9GRV5", "WBGene00006616", "Q23595", "WBGene00014077", "A0A0K3AV89", "Y32G9A.6d", "G5EBJ4", "WBGene00013835", "O18152", "WBGene00012124", "Q9GYM5", "WBGene00019782", "Q23639", "WBGene00000840", "P91404", "WBGene00019993", "G5ECR7", "WBGene00001235", "Q23457", "WBGene00004320", "Q17390", "WBGene00000837", "Q19213", "WBGene00006922", "P17221", "WBGene00001411", "Q9BKS1", "WBGene00001236", "O61795", "WBGene00020030", "Q20183", "WBGene00006415", "A0PD34", "WBGene00014848", "O62200", "WBGene00014848", "Q03607", "WBGene00014848", "G5ED84", "WBGene00020952", "Q21854", "WBGene00006493", "G5EGS4", "WBGene00002184", "Q17391", "WBGene00000838", "Q94251", "WBGene00001089", "Q17531", "WBGene00007206", "Q17962", "WBGene00007574", "O17324", "WBGene00015673", "Q20367", "WBGene00005013", "Q9GYI0", "WBGene00017920", "O45323", "WBGene00008439", "P34284", "WBGene00015350", "Q6A590", "WBGene00020884", "G5EES6", "WBGene00007333", "Q9N3G1", "WBGene00021815", "Q22071", "WBGene00003177", "G5ECU1", "WBGene00004807", "Q17389", "WBGene00000836", "Q93349", "WBGene00007985", "O45498", "WBGene00009556", "Q965N7", "WBGene00021596", "Q965N6", "WBGene00021597", "G5EFS1", "WBGene00002069", "Q9BL53", "WBGene00022139", "Q9GRV5", "WBGene00006616", "Q23595", "WBGene00014077", "A0A0K3AV89", "Y32G9A.6d", "G5EBJ4", "WBGene00013835", "O18152", "WBGene00012124", "Q9GYM5", "WBGene00019782", "Q23639", "WBGene00000840", "P91404", "WBGene00019993", "G5ED41", "WBGene00013606" ] }, "reaction_10569046": { "compartment": "compartment_70101", "id": "reaction_10569046", "reactome": "R-CEL-8951644", "name": "Release of mature NEDD8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10556648" ], "products": [ "species_10556637", "species_10556646" ], "modifiers": [], "additional_components": [ "Q93725", "WBGene00003587", "Q9UAV3", "WBGene00006721", "Q86FN3", "WBGene00006738", "Q9UAV3", "WBGene00006721", "Q86FN3", "WBGene00006738", "WBGene00003587" ] }, "reaction_10570089": { "compartment": "compartment_7660", "id": "reaction_10570089", "reactome": "R-CEL-8956045", "name": "COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10570082" ], "products": [ "species_10570086", "species_10570084" ], "modifiers": [ [ "species_10556775", "catalyst" ] ], "additional_components": [ "Q21554", "WBGene00010890", "Q23457", "WBGene00004320", "Q965F9", "WBGene00003917", "Q18963", "WBGene00008403", "Q93759", "WBGene00009976", "Q22059", "WBGene00011318", "Q4W5Q8", "WBGene00044440", "Q09309", "WBGene00017683", "Q21934", "WBGene00011242", "Q23494", "WBGene00022742", "P90916", "WBGene00003036", "P90917", "WBGene00004312", "P90794", "WBGene00008419", "Q17963", "WBGene00006474", "Q09392", "WBGene00018564", "Q93725", "WBGene00003587", "Q17392", "WBGene00000839", "Q7JP60", "WBGene00019959", "Q7JP60", "WBGene00019959", "Q21554", "WBGene00010890", "Q23457", "WBGene00004320", "Q965F9", "WBGene00003917", "Q18963", "WBGene00008403", "Q93759", "WBGene00009976", "Q22059", "WBGene00011318", "Q4W5Q8", "WBGene00044440", "Q09309", "WBGene00017683", "Q21934", "WBGene00011242", "Q23494", "WBGene00022742", "P90916", "WBGene00003036", "P90917", "WBGene00004312", "P90794", "WBGene00008419", "Q17963", "WBGene00006474", "Q09392", "WBGene00018564", "Q17392", "WBGene00000839", "WBGene00003587", "Q9GS00", "WBGene00000813", "Q9N359", "WBGene00000816", "P91001", "WBGene00000817", "O01422", "WBGene00000814", "Q9N425", "WBGene00000815", "Q95PZ0", "WBGene00000818" ] }, "reaction_10570104": { "compartment": "compartment_70101", "id": "reaction_10570104", "reactome": "R-CEL-8956106", "name": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10532188", "species_10570093" ], "products": [ "species_10532186", "species_10570097" ], "modifiers": [ [ "species_10570093", "catalyst" ], [ "species_10570102", "inhibitor" ] ], "additional_components": [ "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "P35129", "WBGene00002344", "P91853", "WBGene00006732", "Q17720", "WBGene00006717", "Q20617", "WBGene00006719", "G5EGD2", "WBGene00001851", "Q17390", "WBGene00000837", "Q93725", "WBGene00003587", "Q7JP60", "WBGene00019959", "G5ECR7", "WBGene00001235", "Q19213", "WBGene00006922", "Q9BKS1", "WBGene00001236", "Q23457", "WBGene00004320", "P35129", "WBGene00002344", "P91853", "WBGene00006732", "Q17720", "WBGene00006717", "Q20617", "WBGene00006719", "Q17390", "WBGene00000837", "Q93725", "WBGene00003587", "Q7JP60", "WBGene00019959", "G5ECR7", "WBGene00001235", "Q19213", "WBGene00006922", "Q9BKS1", "WBGene00001236", "Q23457", "WBGene00004320", "G5EGD2", "WBGene00001851", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "G5EGD2", "WBGene00001851", "Q17390", "WBGene00000837", "Q93725", "WBGene00003587", "Q7JP60", "WBGene00019959", "G5ECR7", "WBGene00001235", "Q19213", "WBGene00006922", "Q9BKS1", "WBGene00001236", "Q23457", "WBGene00004320", "Q17390", "WBGene00000837", "Q93725", "WBGene00003587", "Q7JP60", "WBGene00019959", "G5ECR7", "WBGene00001235", "Q19213", "WBGene00006922", "Q9BKS1", "WBGene00001236", "Q23457", "WBGene00004320" ] }, "reaction_10569981": { "compartment": "compartment_7660", "id": "reaction_10569981", "reactome": "R-CEL-8955245", "name": "CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10569752", "species_10569977" ], "products": [ "species_10569979" ], "modifiers": [], "additional_components": [ "Q21554", "WBGene00010890", "Q23457", "WBGene00004320", "Q965F9", "WBGene00003917", "Q18963", "WBGene00008403", "Q93759", "WBGene00009976", "Q22059", "WBGene00011318", "Q4W5Q8", "WBGene00044440", "Q09309", "WBGene00017683", "Q21934", "WBGene00011242", "Q23494", "WBGene00022742", "P90916", "WBGene00003036", "P90917", "WBGene00004312", "P90794", "WBGene00008419", "Q17963", "WBGene00006474", "Q09392", "WBGene00018564", "Q17392", "WBGene00000839", "WBGene00013606", "G5ED41", "WBGene00013606", "Q21554", "WBGene00010890", "Q23457", "WBGene00004320", "Q965F9", "WBGene00003917", "Q18963", "WBGene00008403", "Q93759", "WBGene00009976", "Q22059", "WBGene00011318", "Q4W5Q8", "WBGene00044440", "Q09309", "WBGene00017683", "Q21934", "WBGene00011242", "Q23494", "WBGene00022742", "P90916", "WBGene00003036", "P90917", "WBGene00004312", "P90794", "WBGene00008419", "Q17963", "WBGene00006474", "Q09392", "WBGene00018564", "Q17392", "WBGene00000839" ] }, "reaction_10570060": { "compartment": "compartment_70101", "id": "reaction_10570060", "reactome": "R-CEL-8956040", "name": "COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10570047" ], "products": [ "species_10570057", "species_10556646" ], "modifiers": [ [ "species_10566026", "catalyst" ] ], "additional_components": [ "Q7JP60", "WBGene00019959", "O61795", "WBGene00020030", "Q20183", "WBGene00006415", "A0PD34", "WBGene00014848", "O62200", "WBGene00014848", "Q03607", "WBGene00014848", "G5ED84", "WBGene00020952", "Q21854", "WBGene00006493", "G5EGS4", "WBGene00002184", "Q23457", "WBGene00004320", "Q17391", "WBGene00000838", "Q93725", "WBGene00003587", "G5ECR7", "WBGene00001235", "Q17390", "WBGene00000837", "Q9BKS1", "WBGene00001236", "Q19213", "WBGene00006922", "P17221", "WBGene00001411", "Q94251", "WBGene00001089", "Q17531", "WBGene00007206", "Q17962", "WBGene00007574", "O17324", "WBGene00015673", "Q20367", "WBGene00005013", "Q9GYI0", "WBGene00017920", "O45323", "WBGene00008439", "P34284", "WBGene00015350", "Q6A590", "WBGene00020884", "G5EES6", "WBGene00007333", "Q9N3G1", "WBGene00021815", "Q22071", "WBGene00003177", "Q17389", "WBGene00000836", "G5ECU1", "WBGene00004807", "Q9U3C8", "WBGene00010428", "Q93349", "WBGene00007985", "O45498", "WBGene00009556", "Q965N7", "WBGene00021596", "Q965N6", "WBGene00021597", "G5EFS1", "WBGene00002069", "Q9BL53", "WBGene00022139", "Q9GRV5", "WBGene00006616", "Q23595", "WBGene00014077", "A0A0K3AV89", "Y32G9A.6d", "G5EBJ4", "WBGene00013835", "O18152", "WBGene00012124", "Q9GYM5", "WBGene00019782", "Q23639", "WBGene00000840", "P91404", "WBGene00019993", "Q94251", "WBGene00001089", "Q17531", "WBGene00007206", "Q17962", "WBGene00007574", "O17324", "WBGene00015673", "Q20367", "WBGene00005013", "Q9GYI0", "WBGene00017920", "O45323", "WBGene00008439", "P34284", "WBGene00015350", "Q6A590", "WBGene00020884", "G5EES6", "WBGene00007333", "Q9N3G1", "WBGene00021815", "Q22071", "WBGene00003177", "G5ECU1", "WBGene00004807", "Q17389", "WBGene00000836", "Q23457", "WBGene00004320", "Q7JP60", "WBGene00019959", "Q9U3C8", "WBGene00010428", "G5ECR7", "WBGene00001235", "Q17390", "WBGene00000837", "Q19213", "WBGene00006922", "P17221", "WBGene00001411", "Q9BKS1", "WBGene00001236", "O61795", "WBGene00020030", "Q20183", "WBGene00006415", "A0PD34", "WBGene00014848", "O62200", "WBGene00014848", "Q03607", "WBGene00014848", "G5ED84", "WBGene00020952", "Q21854", "WBGene00006493", "G5EGS4", "WBGene00002184", "Q17391", "WBGene00000838", "Q93349", "WBGene00007985", "O45498", "WBGene00009556", "Q965N7", "WBGene00021596", "Q965N6", "WBGene00021597", "G5EFS1", "WBGene00002069", "Q9BL53", "WBGene00022139", "Q9GRV5", "WBGene00006616", "Q23595", "WBGene00014077", "A0A0K3AV89", "Y32G9A.6d", "G5EBJ4", "WBGene00013835", "O18152", "WBGene00012124", "Q9GYM5", "WBGene00019782", "Q23639", "WBGene00000840", "P91404", "WBGene00019993", "WBGene00003587", "Q9N359", "WBGene00000816", "P91001", "WBGene00000817", "Q95PZ0", "WBGene00000818", "Q9GS00", "WBGene00000813", "O01422", "WBGene00000814", "Q9N425", "WBGene00000815" ] }, "reaction_10570095": { "compartment": "compartment_70101", "id": "reaction_10570095", "reactome": "R-CEL-8956103", "name": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds hydroxyprolyl-HIF-alpha", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10570091", "species_10532134" ], "products": [ "species_10570093" ], "modifiers": [], "additional_components": [ "Q17390", "WBGene00000837", "Q93725", "WBGene00003587", "Q7JP60", "WBGene00019959", "G5ECR7", "WBGene00001235", "Q19213", "WBGene00006922", "Q9BKS1", "WBGene00001236", "Q23457", "WBGene00004320", "WBGene00001851", "G5EGD2", "WBGene00001851", "Q17390", "WBGene00000837", "Q93725", "WBGene00003587", "Q7JP60", "WBGene00019959", "G5ECR7", "WBGene00001235", "Q19213", "WBGene00006922", "Q9BKS1", "WBGene00001236", "Q23457", "WBGene00004320" ] }, "reaction_10520016": { "compartment": "compartment_70101", "id": "reaction_10520016", "reactome": "R-CEL-381111", "name": "EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10505631", "species_113592" ], "products": [ "species_10520013", "species_29370" ], "modifiers": [ [ "species_10519989", "catalyst" ] ], "additional_components": [ "Q9BKU3", "WBGene00021351", "Q21230", "WBGene00010560", "Q95XR0", "WBGene00021466", "Q21230", "WBGene00010560", "Q9BKU3", "WBGene00021351", "Q95XR0", "WBGene00021466", "Q19192", "WBGene00003970" ] }, "reaction_10519991": { "compartment": "compartment_12045", "id": "reaction_10519991", "reactome": "R-CEL-381087", "name": "Dimerization of PERK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10519980" ], "products": [ "species_10519989" ], "modifiers": [], "additional_components": [ "WBGene00003970", "Q19192", "WBGene00003970" ] }, "reaction_10520006": { "compartment": "compartment_12045", "id": "reaction_10520006", "reactome": "R-CEL-381091", "name": "IRE1 dimer autophosphorylates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10519998", "species_113592" ], "products": [ "species_29370", "species_10520003" ], "modifiers": [ [ "species_10519998", "catalyst" ] ], "additional_components": [ "Q09499", "WBGene00002147", "Q09499", "WBGene00002147", "Q09499", "WBGene00002147" ] }, "reaction_10520008": { "compartment": "compartment_12045", "id": "reaction_10520008", "reactome": "R-CEL-381109", "name": "IRE1 binds IRE1 forming dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10519996" ], "products": [ "species_10519998" ], "modifiers": [], "additional_components": [ "WBGene00002147", "Q09499", "WBGene00002147" ] }, "reaction_10567201": { "compartment": "compartment_20699", "id": "reaction_10567201", "reactome": "R-CEL-8874208", "name": "CREB3L3 translocates from the endoplasmic reticulum membrane to the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10567199" ], "products": [ "species_10567195" ], "modifiers": [], "additional_components": [ "WBGene00002783", "WBGene00002783" ] }, "reaction_10567187": { "compartment": "compartment_7660", "id": "reaction_10567187", "reactome": "R-CEL-8874202", "name": "CREB3L3 translocates from the cytosol to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10567179" ], "products": [ "species_10567185" ], "modifiers": [], "additional_components": [ "WBGene00002783", "WBGene00002783" ] }, "reaction_10567183": { "compartment": "compartment_20699", "id": "reaction_10567183", "reactome": "R-CEL-8874201", "name": "MBTPS2 (S2P) cleaves CREB3L3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10567177" ], "products": [ "species_10567181", "species_10567179" ], "modifiers": [ [ "species_10522008", "catalyst" ] ], "additional_components": [ "WBGene00002783", "WBGene00002783", "WBGene00002783", "WBGene00013225" ] }, "reaction_10519975": { "compartment": "compartment_70101", "id": "reaction_10519975", "reactome": "R-CEL-381026", "name": "ATF6 (ATF6-alpha) translocates from the cytosol to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10519971" ], "products": [ "species_10519973" ], "modifiers": [], "additional_components": [ "WBGene00000222", "WBGene00000222" ] }, "reaction_10522011": { "compartment": "compartment_20699", "id": "reaction_10522011", "reactome": "R-CEL-420818", "name": "MBTPS2 (S2P) cleaves ATF6 (ATF6-alpha)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10520023" ], "products": [ "species_10522003", "species_10519971" ], "modifiers": [ [ "species_10522008", "catalyst" ] ], "additional_components": [ "WBGene00000222", "WBGene00000222", "WBGene00000222", "WBGene00013225" ] }, "reaction_10520031": { "compartment": "compartment_12045", "id": "reaction_10520031", "reactome": "R-CEL-381186", "name": "ATF6 (ATF6-alpha) translocates from the endoplasmic reticulum to the Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10520027" ], "products": [ "species_10520021" ], "modifiers": [], "additional_components": [ "WBGene00000222", "WBGene00000222" ] }, "reaction_10517698": { "compartment": "compartment_876", "id": "reaction_10517698", "reactome": "R-CEL-265177", "name": "Exocyst complex formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10517679", "species_10517694", "species_10517659", "species_10517674", "species_10517689", "species_10517669", "species_10517684", "species_10517664" ], "products": [ "species_10517696" ], "modifiers": [], "additional_components": [ "WBGene00013687", "WBGene00016606", "WBGene00004753", "WBGene00016188", "WBGene00017284", "WBGene00016376", "WBGene00018703", "WBGene00004752", "Q22706", "WBGene00004752", "Q20678", "WBGene00018703", "Q18406", "WBGene00016376", "Q19262", "WBGene00017284", "Q18286", "WBGene00016188", "Q9XWS2", "WBGene00004753", "P91149", "WBGene00016606", "Q95Q35", "WBGene00013687" ] }, "reaction_10555315": { "compartment": "compartment_70101", "id": "reaction_10555315", "reactome": "R-CEL-5676917", "name": "MRSBs reduce L-methyl-(R)-S-oxide to L-methionine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5676932", "species_10506160" ], "products": [ "species_10506158", "species_174390" ], "modifiers": [ [ "species_10555312", "catalyst" ] ], "additional_components": [ "WBGene00015062", "WBGene00015062", "P34436", "WBGene00018419" ] }, "reaction_10555323": { "compartment": "compartment_70101", "id": "reaction_10555323", "reactome": "R-CEL-5676966", "name": "PCMT1 transfers CH3 from AdoMet to isoAsp to form MetAsp", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5687536", "species_71284" ], "products": [ "species_5687529", "species_71285" ], "modifiers": [ [ "species_10555320", "catalyst" ] ], "additional_components": [ "WBGene00003954" ] }, "reaction_10522946": { "compartment": "compartment_876", "id": "reaction_10522946", "reactome": "R-CEL-427656", "name": "SLC34A1,2 cotransports Pi, 3Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109277", "species_74113" ], "products": [ "species_29372", "species_83910" ], "modifiers": [ [ "species_10522943", "catalyst" ] ], "additional_components": [ "WBGene00022767" ] }, "reaction_10555765": { "compartment": "compartment_3828046", "id": "reaction_10555765", "reactome": "R-CEL-5684864", "name": "NAPSA, CTSH, PGA3-5 cleave pro-SFTPB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10555678", "species_5685882" ], "products": [ "species_10555690", "species_10555684", "species_10555696" ], "modifiers": [ [ "species_10555762", "catalyst" ] ], "additional_components": [ "Q18276", "WBGene00004995", "Q18279", "WBGene00004993", "Q18276", "WBGene00004995", "Q18279", "WBGene00004993", "Q18276", "WBGene00004995", "Q18279", "WBGene00004993", "Q18276", "WBGene00004995", "Q18279", "WBGene00004993", "Q18020", "WBGene00007605", "Q21966", "WBGene00000217", "Q22972", "WBGene00017881", "Q7JKL9", "WBGene00013973", "Q86NE0", "WBGene00000215", "Q8MYN5", "WBGene00012683", "Q8MYN6", "WBGene00012682", "Q8MYN7", "WBGene00012681", "G5EC01", "WBGene00077655", "G5EEI4", "WBGene00000214", "O01530", "WBGene00000219", "O01531", "WBGene00017678", "O01532", "WBGene00000218", "O45072", "WBGene00015700", "P55956", "WBGene00000216" ] }, "reaction_10555575": { "compartment": "compartment_2133233", "id": "reaction_10555575", "reactome": "R-CEL-5683714", "name": "ABCA3 transports PC, PG from ER membrane to lamellar body", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_5684863" ], "products": [ "species_29372", "species_29370", "species_5684869" ], "modifiers": [ [ "species_10555572", "catalyst" ] ], "additional_components": [ "species_194276", "species_1524042", "species_194276", "species_1524042", "WBGene00000022" ] }, "reaction_10558534": { "compartment": "compartment_3828046", "id": "reaction_10558534", "reactome": "R-CEL-6791016", "name": "SFTPB binds itself", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10555684" ], "products": [ "species_10555767" ], "modifiers": [], "additional_components": [ "Q18276", "WBGene00004995", "Q18279", "WBGene00004993", "Q18276", "WBGene00004995", "Q18279", "WBGene00004993" ] }, "reaction_10572265": { "compartment": "compartment_12045", "id": "reaction_10572265", "reactome": "R-CEL-9624789", "name": "pro-SFTPB translocates from ER membrane to multivesicle body", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10572263" ], "products": [ "species_10555678" ], "modifiers": [], "additional_components": [ "Q18276", "WBGene00004995", "Q18279", "WBGene00004993", "Q18276", "WBGene00004995", "Q18279", "WBGene00004993" ] }, "reaction_10509923": { "compartment": "compartment_70101", "id": "reaction_10509923", "reactome": "R-CEL-156930", "name": "GTP-binding activates eEF2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509919", "species_29438" ], "products": [ "species_10509921" ], "modifiers": [], "additional_components": [ "WBGene00001167", "species_29438", "P29691", "WBGene00001167" ] }, "reaction_10505689": { "compartment": "compartment_70101", "id": "reaction_10505689", "reactome": "R-CEL-72631", "name": "Formation of the cap-binding eIF4F complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10505660", "species_10505655", "species_10505665" ], "products": [ "species_10505667" ], "modifiers": [], "additional_components": [ "WBGene00002061", "Q20935", "WBGene00018997", "P27639", "WBGene00002083", "WBGene00002066", "A0A486WX07", "WBGene00002066", "Q20935", "WBGene00018997", "P27639", "WBGene00002083", "O61955", "WBGene00002061" ] }, "reaction_10505697": { "compartment": "compartment_70101", "id": "reaction_10505697", "reactome": "R-CEL-72669", "name": "Met-tRNAi binds to eIF2:GTP to form the ternary complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_72393", "species_10505633" ], "products": [ "species_10505635" ], "modifiers": [ [ "species_29438", "catalyst" ] ], "additional_components": [ "species_29438", "Q9BKU3", "WBGene00021351", "Q21230", "WBGene00010560", "Q95XR0", "WBGene00021466", "species_29438", "Q9BKU3", "WBGene00021351", "Q21230", "WBGene00010560", "Q95XR0", "WBGene00021466" ] }, "reaction_10505997": { "compartment": "compartment_70101", "id": "reaction_10505997", "reactome": "R-CEL-72691", "name": "Formation of the 43S pre-initiation complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10505993", "species_10505635" ], "products": [ "species_10505637" ], "modifiers": [], "additional_components": [ "P51403", "WBGene00004471", "Q9NEN6", "WBGene00004475", "Q8WQA8", "WBGene00004489", "Q23312", "WBGene00004476", "O01869", "WBGene00004479", "P49197", "WBGene00004490", "P48156", "WBGene00004477", "Q20206", "WBGene00004480", "Q19877", "WBGene00004492", "Q20228", "WBGene00004478", "P49196", "WBGene00004481", "Q1XFY9", "WBGene00004493", "P46769", "WBGene00004469", "P51404", "WBGene00004482", "P52821", "WBGene00004494", "Q9TXP0", "WBGene00004496", "P48150", "WBGene00004483", "O45499", "WBGene00004495", "Q9N3X2", "WBGene00004473", "Q9XVP0", "WBGene00004484", "Q95Y04", "WBGene00004497", "Q22054", "WBGene00004485", "P90983", "WBGene00004498", "O01692", "WBGene00004486", "P48152", "WBGene00004472", "O18240", "WBGene00004487", "O18650", "WBGene00004488", "P48154", "WBGene00004470", "O17218", "WBGene00004491", "P49041", "WBGene00004474", "Q95QW0", "WBGene00015920", "O01974", "WBGene00001231", "Q94261", "WBGene00019543", "P34339", "WBGene00001209", "Q9XWP7", "WBGene00012738", "P30642", "WBGene00001227", "Q965S8", "WBGene00001232", "O02328", "WBGene00001226", "Q19706", "WBGene00001230", "O61820", "WBGene00001228", "Q18967", "WBGene00001229", "Q9XUP3", "WBGene00001233", "Q9XWI6", "WBGene00001225", "Q9TXU7", "WBGene00019162", "species_29438", "Q9BKU3", "WBGene00021351", "Q21230", "WBGene00010560", "Q95XR0", "WBGene00021466", "species_29438", "Q9BKU3", "WBGene00021351", "Q21230", "WBGene00010560", "Q95XR0", "WBGene00021466", "P51403", "WBGene00004471", "Q9NEN6", "WBGene00004475", "Q8WQA8", "WBGene00004489", "Q23312", "WBGene00004476", "O01869", "WBGene00004479", "P49197", "WBGene00004490", "P48156", "WBGene00004477", "Q20206", "WBGene00004480", "Q19877", "WBGene00004492", "Q20228", "WBGene00004478", "P49196", "WBGene00004481", "Q1XFY9", "WBGene00004493", "P46769", "WBGene00004469", "P51404", "WBGene00004482", "P52821", "WBGene00004494", "Q9TXP0", "WBGene00004496", "P48150", "WBGene00004483", "O45499", "WBGene00004495", "Q9N3X2", "WBGene00004473", "Q9XVP0", "WBGene00004484", "Q95Y04", "WBGene00004497", "Q22054", "WBGene00004485", "P90983", "WBGene00004498", "O01692", "WBGene00004486", "P48152", "WBGene00004472", "O18240", "WBGene00004487", "O18650", "WBGene00004488", "P48154", "WBGene00004470", "O17218", "WBGene00004491", "P49041", "WBGene00004474", "Q95QW0", "WBGene00015920", "O01974", "WBGene00001231", "Q94261", "WBGene00019543", "P34339", "WBGene00001209", "Q9XWP7", "WBGene00012738", "P30642", "WBGene00001227", "Q965S8", "WBGene00001232", "O02328", "WBGene00001226", "Q19706", "WBGene00001230", "O61820", "WBGene00001228", "Q18967", "WBGene00001229", "Q9XUP3", "WBGene00001233", "Q9XWI6", "WBGene00001225", "Q9TXU7", "WBGene00019162" ] }, "reaction_10505695": { "compartment": "compartment_70101", "id": "reaction_10505695", "reactome": "R-CEL-72663", "name": "De novo formation of eIF2:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10505631", "species_29438" ], "products": [ "species_10505633" ], "modifiers": [], "additional_components": [ "Q9BKU3", "WBGene00021351", "Q21230", "WBGene00010560", "Q95XR0", "WBGene00021466", "species_29438", "Q9BKU3", "WBGene00021351", "Q21230", "WBGene00010560", "Q95XR0", "WBGene00021466" ] }, "reaction_10505987": { "compartment": "compartment_70101", "id": "reaction_10505987", "reactome": "R-CEL-72671", "name": "eIF5B:GTP is hydrolyzed and released", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10505981" ], "products": [ "species_10505983", "species_29372", "species_10505985" ], "modifiers": [], "additional_components": [ "P91914", "WBGene00004441", "Q19869", "WBGene00004440", "O01868", "WBGene00004436", "P48162", "WBGene00004438", "P52819", "WBGene00004434", "P48158", "WBGene00004435", "Q09533", "WBGene00004421", "P34334", "WBGene00004433", "O02639", "WBGene00004431", "Q95Y90", "WBGene00004420", "O44480", "WBGene00004432", "Q22716", "WBGene00004446", "Q9U332", "WBGene00004445", "Q9XWS4", "WBGene00004444", "P52814", "WBGene00004453", "O45226", "WBGene00004443", "Q21930", "WBGene00004442", "P48166", "WBGene00004454", "Q9BKU5", "WBGene00021350", "P50880", "WBGene00004414", "P61866", "WBGene00004424", "O17570", "WBGene00004452", "Q19162", "WBGene00004423", "Q9U2A8", "WBGene00004456", "Q9N4I4", "WBGene00004412", "O62388", "WBGene00012179", "O01504", "WBGene00016493", "P49181", "WBGene00004450", "P91913", "WBGene00004409", "P49180", "WBGene00004447", "Q93572", "WBGene00004408", "P34662", "WBGene00004449", "Q9XVF7", "WBGene00004413", "O45946", "WBGene00004430", "Q966C6", "WBGene00004419", "Q9BL19", "WBGene00004429", "O01802", "WBGene00004418", "P91374", "WBGene00004427", "P47991", "WBGene00004417", "Q9XVE9", "WBGene00004426", "P49405", "WBGene00004416", "Q27389", "WBGene00004428", "P37165", "WBGene00006725", "P91128", "WBGene00004425", "O02056", "WBGene00004415", "P51403", "WBGene00004471", "Q9NEN6", "WBGene00004475", "Q8WQA8", "WBGene00004489", "Q23312", "WBGene00004476", "O01869", "WBGene00004479", "P49197", "WBGene00004490", "P48156", "WBGene00004477", "Q20206", "WBGene00004480", "Q19877", "WBGene00004492", "Q20228", "WBGene00004478", "P49196", "WBGene00004481", "Q1XFY9", "WBGene00004493", "P46769", "WBGene00004469", "P51404", "WBGene00004482", "P52821", "WBGene00004494", "Q9TXP0", "WBGene00004496", "P48150", "WBGene00004483", "O45499", "WBGene00004495", "Q9N3X2", "WBGene00004473", "Q9XVP0", "WBGene00004484", "Q95Y04", "WBGene00004497", "Q22054", "WBGene00004485", "P90983", "WBGene00004498", "O01692", "WBGene00004486", "P48152", "WBGene00004472", "O18240", "WBGene00004487", "O18650", "WBGene00004488", "P48154", "WBGene00004470", "O17218", "WBGene00004491", "P49041", "WBGene00004474", "G5EGT7", "WBGene00021857", "species_29438", "G5EGT7", "WBGene00021857", "species_29420", "P91914", "WBGene00004441", "Q19869", "WBGene00004440", "O01868", "WBGene00004436", "P48162", "WBGene00004438", "P52819", "WBGene00004434", "P48158", "WBGene00004435", "Q09533", "WBGene00004421", "P34334", "WBGene00004433", "O02639", "WBGene00004431", "Q95Y90", "WBGene00004420", "O44480", "WBGene00004432", "Q22716", "WBGene00004446", "Q9U332", "WBGene00004445", "Q9XWS4", "WBGene00004444", "P52814", "WBGene00004453", "O45226", "WBGene00004443", "Q21930", "WBGene00004442", "P48166", "WBGene00004454", "Q9BKU5", "WBGene00021350", "P50880", "WBGene00004414", "P61866", "WBGene00004424", "O17570", "WBGene00004452", "Q19162", "WBGene00004423", "Q9U2A8", "WBGene00004456", "Q9N4I4", "WBGene00004412", "O62388", "WBGene00012179", "O01504", "WBGene00016493", "P49181", "WBGene00004450", "P91913", "WBGene00004409", "P49180", "WBGene00004447", "Q93572", "WBGene00004408", "P34662", "WBGene00004449", "Q9XVF7", "WBGene00004413", "O45946", "WBGene00004430", "Q966C6", "WBGene00004419", "Q9BL19", "WBGene00004429", "O01802", "WBGene00004418", "P91374", "WBGene00004427", "P47991", "WBGene00004417", "Q9XVE9", "WBGene00004426", "P49405", "WBGene00004416", "Q27389", "WBGene00004428", "P37165", "WBGene00006725", "P91128", "WBGene00004425", "O02056", "WBGene00004415", "P51403", "WBGene00004471", "Q9NEN6", "WBGene00004475", "Q8WQA8", "WBGene00004489", "Q23312", "WBGene00004476", "O01869", "WBGene00004479", "P49197", "WBGene00004490", "P48156", "WBGene00004477", "Q20206", "WBGene00004480", "Q19877", "WBGene00004492", "Q20228", "WBGene00004478", "P49196", "WBGene00004481", "Q1XFY9", "WBGene00004493", "P46769", "WBGene00004469", "P51404", "WBGene00004482", "P52821", "WBGene00004494", "Q9TXP0", "WBGene00004496", "P48150", "WBGene00004483", "O45499", "WBGene00004495", "Q9N3X2", "WBGene00004473", "Q9XVP0", "WBGene00004484", "Q95Y04", "WBGene00004497", "Q22054", "WBGene00004485", "P90983", "WBGene00004498", "O01692", "WBGene00004486", "P48152", "WBGene00004472", "O18240", "WBGene00004487", "O18650", "WBGene00004488", "P48154", "WBGene00004470", "O17218", "WBGene00004491", "P49041", "WBGene00004474" ] }, "reaction_10505989": { "compartment": "compartment_70101", "id": "reaction_10505989", "reactome": "R-CEL-72672", "name": "The 60S subunit joins the translation initiation complex ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10505979", "species_10505683", "species_10505970" ], "products": [ "species_10505981" ], "modifiers": [], "additional_components": [ "G5EGT7", "WBGene00021857", "species_29438", "P51403", "WBGene00004471", "Q9NEN6", "WBGene00004475", "Q8WQA8", "WBGene00004489", "Q23312", "WBGene00004476", "O01869", "WBGene00004479", "P49197", "WBGene00004490", "P48156", "WBGene00004477", "Q20206", "WBGene00004480", "Q19877", "WBGene00004492", "Q20228", "WBGene00004478", "P49196", "WBGene00004481", "Q1XFY9", "WBGene00004493", "P46769", "WBGene00004469", "P51404", "WBGene00004482", "P52821", "WBGene00004494", "Q9TXP0", "WBGene00004496", "P48150", "WBGene00004483", "O45499", "WBGene00004495", "Q9N3X2", "WBGene00004473", "Q9XVP0", "WBGene00004484", "Q95Y04", "WBGene00004497", "Q22054", "WBGene00004485", "P90983", "WBGene00004498", "O01692", "WBGene00004486", "P48152", "WBGene00004472", "O18240", "WBGene00004487", "O18650", "WBGene00004488", "P48154", "WBGene00004470", "O17218", "WBGene00004491", "P49041", "WBGene00004474", "P91914", "WBGene00004441", "Q19869", "WBGene00004440", "O01868", "WBGene00004436", "P48162", "WBGene00004438", "P52819", "WBGene00004434", "P48158", "WBGene00004435", "Q09533", "WBGene00004421", "P34334", "WBGene00004433", "O02639", "WBGene00004431", "Q95Y90", "WBGene00004420", "O44480", "WBGene00004432", "Q22716", "WBGene00004446", "Q9U332", "WBGene00004445", "Q9XWS4", "WBGene00004444", "P52814", "WBGene00004453", "O45226", "WBGene00004443", "Q21930", "WBGene00004442", "P48166", "WBGene00004454", "Q9BKU5", "WBGene00021350", "P50880", "WBGene00004414", "P61866", "WBGene00004424", "O17570", "WBGene00004452", "Q19162", "WBGene00004423", "Q9U2A8", "WBGene00004456", "Q9N4I4", "WBGene00004412", "O62388", "WBGene00012179", "O01504", "WBGene00016493", "P49181", "WBGene00004450", "P91913", "WBGene00004409", "P49180", "WBGene00004447", "Q93572", "WBGene00004408", "P34662", "WBGene00004449", "Q9XVF7", "WBGene00004413", "O45946", "WBGene00004430", "Q966C6", "WBGene00004419", "Q9BL19", "WBGene00004429", "O01802", "WBGene00004418", "P91374", "WBGene00004427", "P47991", "WBGene00004417", "Q9XVE9", "WBGene00004426", "P49405", "WBGene00004416", "Q27389", "WBGene00004428", "P37165", "WBGene00006725", "P91128", "WBGene00004425", "O02056", "WBGene00004415", "P91914", "WBGene00004441", "Q19869", "WBGene00004440", "O01868", "WBGene00004436", "P48162", "WBGene00004438", "P52819", "WBGene00004434", "P48158", "WBGene00004435", "Q09533", "WBGene00004421", "P34334", "WBGene00004433", "O02639", "WBGene00004431", "Q95Y90", "WBGene00004420", "O44480", "WBGene00004432", "Q22716", "WBGene00004446", "Q9U332", "WBGene00004445", "Q9XWS4", "WBGene00004444", "P52814", "WBGene00004453", "O45226", "WBGene00004443", "Q21930", "WBGene00004442", "P48166", "WBGene00004454", "Q9BKU5", "WBGene00021350", "P50880", "WBGene00004414", "P61866", "WBGene00004424", "O17570", "WBGene00004452", "Q19162", "WBGene00004423", "Q9U2A8", "WBGene00004456", "Q9N4I4", "WBGene00004412", "O62388", "WBGene00012179", "O01504", "WBGene00016493", "P49181", "WBGene00004450", "P91913", "WBGene00004409", "P49180", "WBGene00004447", "Q93572", "WBGene00004408", "P34662", "WBGene00004449", "Q9XVF7", "WBGene00004413", "O45946", "WBGene00004430", "Q966C6", "WBGene00004419", "Q9BL19", "WBGene00004429", "O01802", "WBGene00004418", "P91374", "WBGene00004427", "P47991", "WBGene00004417", "Q9XVE9", "WBGene00004426", "P49405", "WBGene00004416", "Q27389", "WBGene00004428", "P37165", "WBGene00006725", "P91128", "WBGene00004425", "O02056", "WBGene00004415", "P51403", "WBGene00004471", "Q9NEN6", "WBGene00004475", "Q8WQA8", "WBGene00004489", "Q23312", "WBGene00004476", "O01869", "WBGene00004479", "P49197", "WBGene00004490", "P48156", "WBGene00004477", "Q20206", "WBGene00004480", "Q19877", "WBGene00004492", "Q20228", "WBGene00004478", "P49196", "WBGene00004481", "Q1XFY9", "WBGene00004493", "P46769", "WBGene00004469", "P51404", "WBGene00004482", "P52821", "WBGene00004494", "Q9TXP0", "WBGene00004496", "P48150", "WBGene00004483", "O45499", "WBGene00004495", "Q9N3X2", "WBGene00004473", "Q9XVP0", "WBGene00004484", "Q95Y04", "WBGene00004497", "Q22054", "WBGene00004485", "P90983", "WBGene00004498", "O01692", "WBGene00004486", "P48152", "WBGene00004472", "O18240", "WBGene00004487", "O18650", "WBGene00004488", "P48154", "WBGene00004470", "O17218", "WBGene00004491", "P49041", "WBGene00004474", "G5EGT7", "WBGene00021857", "species_29438" ] }, "reaction_10505991": { "compartment": "compartment_70101", "id": "reaction_10505991", "reactome": "R-CEL-72673", "name": "Release of 40S and 60S subunits from the 80S ribosome ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10505614", "species_10505972" ], "products": [ "species_10505614", "species_10505542", "species_10505970" ], "modifiers": [], "additional_components": [ "WBGene00019162", "P91914", "WBGene00004441", "Q19869", "WBGene00004440", "O01868", "WBGene00004436", "P48162", "WBGene00004438", "P52819", "WBGene00004434", "P48158", "WBGene00004435", "Q09533", "WBGene00004421", "P34334", "WBGene00004433", "O02639", "WBGene00004431", "Q95Y90", "WBGene00004420", "O44480", "WBGene00004432", "Q22716", "WBGene00004446", "Q9U332", "WBGene00004445", "Q9XWS4", "WBGene00004444", "P52814", "WBGene00004453", "O45226", "WBGene00004443", "Q21930", "WBGene00004442", "P48166", "WBGene00004454", "Q9BKU5", "WBGene00021350", "P50880", "WBGene00004414", "P61866", "WBGene00004424", "O17570", "WBGene00004452", "Q19162", "WBGene00004423", "Q9U2A8", "WBGene00004456", "Q9N4I4", "WBGene00004412", "O62388", "WBGene00012179", "O01504", "WBGene00016493", "P49181", "WBGene00004450", "P91913", "WBGene00004409", "P49180", "WBGene00004447", "Q93572", "WBGene00004408", "P34662", "WBGene00004449", "Q9XVF7", "WBGene00004413", "O45946", "WBGene00004430", "Q966C6", "WBGene00004419", "Q9BL19", "WBGene00004429", "O01802", "WBGene00004418", "P91374", "WBGene00004427", "P47991", "WBGene00004417", "Q9XVE9", "WBGene00004426", "P49405", "WBGene00004416", "Q27389", "WBGene00004428", "P37165", "WBGene00006725", "P91128", "WBGene00004425", "O02056", "WBGene00004415", "P51403", "WBGene00004471", "Q9NEN6", "WBGene00004475", "Q8WQA8", "WBGene00004489", "Q23312", "WBGene00004476", "O01869", "WBGene00004479", "P49197", "WBGene00004490", "P48156", "WBGene00004477", "Q20206", "WBGene00004480", "Q19877", "WBGene00004492", "Q20228", "WBGene00004478", "P49196", "WBGene00004481", "Q1XFY9", "WBGene00004493", "P46769", "WBGene00004469", "P51404", "WBGene00004482", "P52821", "WBGene00004494", "Q9TXP0", "WBGene00004496", "P48150", "WBGene00004483", "O45499", "WBGene00004495", "Q9N3X2", "WBGene00004473", "Q9XVP0", "WBGene00004484", "Q95Y04", "WBGene00004497", "Q22054", "WBGene00004485", "P90983", "WBGene00004498", "O01692", "WBGene00004486", "P48152", "WBGene00004472", "O18240", "WBGene00004487", "O18650", "WBGene00004488", "P48154", "WBGene00004470", "O17218", "WBGene00004491", "P49041", "WBGene00004474", "WBGene00019162", "P51403", "WBGene00004471", "Q9NEN6", "WBGene00004475", "Q8WQA8", "WBGene00004489", "Q23312", "WBGene00004476", "O01869", "WBGene00004479", "P49197", "WBGene00004490", "P48156", "WBGene00004477", "Q20206", "WBGene00004480", "Q19877", "WBGene00004492", "Q20228", "WBGene00004478", "P49196", "WBGene00004481", "Q1XFY9", "WBGene00004493", "P46769", "WBGene00004469", "P51404", "WBGene00004482", "P52821", "WBGene00004494", "Q9TXP0", "WBGene00004496", "P48150", "WBGene00004483", "O45499", "WBGene00004495", "Q9N3X2", "WBGene00004473", "Q9XVP0", "WBGene00004484", "Q95Y04", "WBGene00004497", "Q22054", "WBGene00004485", "P90983", "WBGene00004498", "O01692", "WBGene00004486", "P48152", "WBGene00004472", "O18240", "WBGene00004487", "O18650", "WBGene00004488", "P48154", "WBGene00004470", "O17218", "WBGene00004491", "P49041", "WBGene00004474", "P91914", "WBGene00004441", "Q19869", "WBGene00004440", "O01868", "WBGene00004436", "P48162", "WBGene00004438", "P52819", "WBGene00004434", "P48158", "WBGene00004435", "Q09533", "WBGene00004421", "P34334", "WBGene00004433", "O02639", "WBGene00004431", "Q95Y90", "WBGene00004420", "O44480", "WBGene00004432", "Q22716", "WBGene00004446", "Q9U332", "WBGene00004445", "Q9XWS4", "WBGene00004444", "P52814", "WBGene00004453", "O45226", "WBGene00004443", "Q21930", "WBGene00004442", "P48166", "WBGene00004454", "Q9BKU5", "WBGene00021350", "P50880", "WBGene00004414", "P61866", "WBGene00004424", "O17570", "WBGene00004452", "Q19162", "WBGene00004423", "Q9U2A8", "WBGene00004456", "Q9N4I4", "WBGene00004412", "O62388", "WBGene00012179", "O01504", "WBGene00016493", "P49181", "WBGene00004450", "P91913", "WBGene00004409", "P49180", "WBGene00004447", "Q93572", "WBGene00004408", "P34662", "WBGene00004449", "Q9XVF7", "WBGene00004413", "O45946", "WBGene00004430", "Q966C6", "WBGene00004419", "Q9BL19", "WBGene00004429", "O01802", "WBGene00004418", "P91374", "WBGene00004427", "P47991", "WBGene00004417", "Q9XVE9", "WBGene00004426", "P49405", "WBGene00004416", "Q27389", "WBGene00004428", "P37165", "WBGene00006725", "P91128", "WBGene00004425", "O02056", "WBGene00004415" ] }, "reaction_10505995": { "compartment": "compartment_70101", "id": "reaction_10505995", "reactome": "R-CEL-72676", "name": "eIF3 and eIF1A bind to the 40S subunit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10505614", "species_10505609", "species_10505542" ], "products": [ "species_10505993" ], "modifiers": [], "additional_components": [ "WBGene00019162", "Q95QW0", "WBGene00015920", "O01974", "WBGene00001231", "Q94261", "WBGene00019543", "P34339", "WBGene00001209", "Q9XWP7", "WBGene00012738", "P30642", "WBGene00001227", "Q965S8", "WBGene00001232", "O02328", "WBGene00001226", "Q19706", "WBGene00001230", "O61820", "WBGene00001228", "Q18967", "WBGene00001229", "Q9XUP3", "WBGene00001233", "Q9XWI6", "WBGene00001225", "P51403", "WBGene00004471", "Q9NEN6", "WBGene00004475", "Q8WQA8", "WBGene00004489", "Q23312", "WBGene00004476", "O01869", "WBGene00004479", "P49197", "WBGene00004490", "P48156", "WBGene00004477", "Q20206", "WBGene00004480", "Q19877", "WBGene00004492", "Q20228", "WBGene00004478", "P49196", "WBGene00004481", "Q1XFY9", "WBGene00004493", "P46769", "WBGene00004469", "P51404", "WBGene00004482", "P52821", "WBGene00004494", "Q9TXP0", "WBGene00004496", "P48150", "WBGene00004483", "O45499", "WBGene00004495", "Q9N3X2", "WBGene00004473", "Q9XVP0", "WBGene00004484", "Q95Y04", "WBGene00004497", "Q22054", "WBGene00004485", "P90983", "WBGene00004498", "O01692", "WBGene00004486", "P48152", "WBGene00004472", "O18240", "WBGene00004487", "O18650", "WBGene00004488", "P48154", "WBGene00004470", "O17218", "WBGene00004491", "P49041", "WBGene00004474", "P51403", "WBGene00004471", "Q9NEN6", "WBGene00004475", "Q8WQA8", "WBGene00004489", "Q23312", "WBGene00004476", "O01869", "WBGene00004479", "P49197", "WBGene00004490", "P48156", "WBGene00004477", "Q20206", "WBGene00004480", "Q19877", "WBGene00004492", "Q20228", "WBGene00004478", "P49196", "WBGene00004481", "Q1XFY9", "WBGene00004493", "P46769", "WBGene00004469", "P51404", "WBGene00004482", "P52821", "WBGene00004494", "Q9TXP0", "WBGene00004496", "P48150", "WBGene00004483", "O45499", "WBGene00004495", "Q9N3X2", "WBGene00004473", "Q9XVP0", "WBGene00004484", "Q95Y04", "WBGene00004497", "Q22054", "WBGene00004485", "P90983", "WBGene00004498", "O01692", "WBGene00004486", "P48152", "WBGene00004472", "O18240", "WBGene00004487", "O18650", "WBGene00004488", "P48154", "WBGene00004470", "O17218", "WBGene00004491", "P49041", "WBGene00004474", "Q95QW0", "WBGene00015920", "O01974", "WBGene00001231", "Q94261", "WBGene00019543", "P34339", "WBGene00001209", "Q9XWP7", "WBGene00012738", "P30642", "WBGene00001227", "Q965S8", "WBGene00001232", "O02328", "WBGene00001226", "Q19706", "WBGene00001230", "O61820", "WBGene00001228", "Q18967", "WBGene00001229", "Q9XUP3", "WBGene00001233", "Q9XWI6", "WBGene00001225", "Q9TXU7", "WBGene00019162" ] }, "reaction_10537497": { "compartment": "compartment_70101", "id": "reaction_10537497", "reactome": "R-CEL-1799332", "name": "Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10537493", "species_10537491" ], "products": [ "species_10537495" ], "modifiers": [], "additional_components": [ "P91914", "WBGene00004441", "Q19869", "WBGene00004440", "O01868", "WBGene00004436", "P48162", "WBGene00004438", "P52819", "WBGene00004434", "P48158", "WBGene00004435", "Q09533", "WBGene00004421", "P34334", "WBGene00004433", "O02639", "WBGene00004431", "Q95Y90", "WBGene00004420", "O44480", "WBGene00004432", "Q22716", "WBGene00004446", "Q9U332", "WBGene00004445", "Q9XWS4", "WBGene00004444", "P52814", "WBGene00004453", "O45226", "WBGene00004443", "Q21930", "WBGene00004442", "P48166", "WBGene00004454", "Q9BKU5", "WBGene00021350", "P50880", "WBGene00004414", "P61866", "WBGene00004424", "O17570", "WBGene00004452", "Q19162", "WBGene00004423", "Q9U2A8", "WBGene00004456", "Q9N4I4", "WBGene00004412", "O62388", "WBGene00012179", "O01504", "WBGene00016493", "P49181", "WBGene00004450", "P91913", "WBGene00004409", "P49180", "WBGene00004447", "Q93572", "WBGene00004408", "P34662", "WBGene00004449", "Q9XVF7", "WBGene00004413", "O45946", "WBGene00004430", "Q966C6", "WBGene00004419", "Q9BL19", "WBGene00004429", "O01802", "WBGene00004418", "P91374", "WBGene00004427", "P47991", "WBGene00004417", "Q9XVE9", "WBGene00004426", "P49405", "WBGene00004416", "Q27389", "WBGene00004428", "P37165", "WBGene00006725", "P91128", "WBGene00004425", "O02056", "WBGene00004415", "P51403", "WBGene00004471", "Q9NEN6", "WBGene00004475", "Q8WQA8", "WBGene00004489", "Q23312", "WBGene00004476", "O01869", "WBGene00004479", "P49197", "WBGene00004490", "P48156", "WBGene00004477", "Q20206", "WBGene00004480", "Q19877", "WBGene00004492", "Q20228", "WBGene00004478", "P49196", "WBGene00004481", "Q1XFY9", "WBGene00004493", "P46769", "WBGene00004469", "P51404", "WBGene00004482", "P52821", "WBGene00004494", "Q9TXP0", "WBGene00004496", "P48150", "WBGene00004483", "O45499", "WBGene00004495", "Q9N3X2", "WBGene00004473", "Q9XVP0", "WBGene00004484", "Q95Y04", "WBGene00004497", "Q22054", "WBGene00004485", "P90983", "WBGene00004498", "O01692", "WBGene00004486", "P48152", "WBGene00004472", "O18240", "WBGene00004487", "O18650", "WBGene00004488", "P48154", "WBGene00004470", "O17218", "WBGene00004491", "P49041", "WBGene00004474", "G5EE80", "WBGene00009012", "P91240", "WBGene00017245", "O16927", "WBGene00017799", "P34642", "WBGene00013984", "O61749", "WBGene00018159", "Q20822", "WBGene00010097", "G5EE80", "WBGene00009012", "P91240", "WBGene00017245", "O16927", "WBGene00017799", "P34642", "WBGene00013984", "O61749", "WBGene00018159", "Q20822", "WBGene00010097", "P91914", "WBGene00004441", "Q19869", "WBGene00004440", "O01868", "WBGene00004436", "P48162", "WBGene00004438", "P52819", "WBGene00004434", "P48158", "WBGene00004435", "Q09533", "WBGene00004421", "P34334", "WBGene00004433", "O02639", "WBGene00004431", "Q95Y90", "WBGene00004420", "O44480", "WBGene00004432", "Q22716", "WBGene00004446", "Q9U332", "WBGene00004445", "Q9XWS4", "WBGene00004444", "P52814", "WBGene00004453", "O45226", "WBGene00004443", "Q21930", "WBGene00004442", "P48166", "WBGene00004454", "Q9BKU5", "WBGene00021350", "P50880", "WBGene00004414", "P61866", "WBGene00004424", "O17570", "WBGene00004452", "Q19162", "WBGene00004423", "Q9U2A8", "WBGene00004456", "Q9N4I4", "WBGene00004412", "O62388", "WBGene00012179", "O01504", "WBGene00016493", "P49181", "WBGene00004450", "P91913", "WBGene00004409", "P49180", "WBGene00004447", "Q93572", "WBGene00004408", "P34662", "WBGene00004449", "Q9XVF7", "WBGene00004413", "O45946", "WBGene00004430", "Q966C6", "WBGene00004419", "Q9BL19", "WBGene00004429", "O01802", "WBGene00004418", "P91374", "WBGene00004427", "P47991", "WBGene00004417", "Q9XVE9", "WBGene00004426", "P49405", "WBGene00004416", "Q27389", "WBGene00004428", "P37165", "WBGene00006725", "P91128", "WBGene00004425", "O02056", "WBGene00004415", "P51403", "WBGene00004471", "Q9NEN6", "WBGene00004475", "Q8WQA8", "WBGene00004489", "Q23312", "WBGene00004476", "O01869", "WBGene00004479", "P49197", "WBGene00004490", "P48156", "WBGene00004477", "Q20206", "WBGene00004480", "Q19877", "WBGene00004492", "Q20228", "WBGene00004478", "P49196", "WBGene00004481", "Q1XFY9", "WBGene00004493", "P46769", "WBGene00004469", "P51404", "WBGene00004482", "P52821", "WBGene00004494", "Q9TXP0", "WBGene00004496", "P48150", "WBGene00004483", "O45499", "WBGene00004495", "Q9N3X2", "WBGene00004473", "Q9XVP0", "WBGene00004484", "Q95Y04", "WBGene00004497", "Q22054", "WBGene00004485", "P90983", "WBGene00004498", "O01692", "WBGene00004486", "P48152", "WBGene00004472", "O18240", "WBGene00004487", "O18650", "WBGene00004488", "P48154", "WBGene00004470", "O17218", "WBGene00004491", "P49041", "WBGene00004474" ] }, "reaction_10556841": { "compartment": "compartment_70101", "id": "reaction_10556841", "reactome": "R-CEL-5691512", "name": "APEH hydrolyses NAc-Ser-protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5691496", "species_29356" ], "products": [ "species_6785226", "species_5691517" ], "modifiers": [ [ "species_10556838", "catalyst" ] ], "additional_components": [ "species_5691517", "species_6785219", "WBGene00001058" ] }, "reaction_10562140": { "compartment": "compartment_70101", "id": "reaction_10562140", "reactome": "R-CEL-6800138", "name": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to ETF1 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10562118", "species_71284" ], "products": [ "species_10562125", "species_71285" ], "modifiers": [ [ "species_10562137", "catalyst" ] ], "additional_components": [ "O45622", "WBGene00010405", "species_29438", "O16520", "WBGene00020269", "O45622", "WBGene00010405", "species_29438", "O16520", "WBGene00020269", "O16582", "WBGene00016341", "O45241", "WBGene00007312" ] }, "reaction_10535108": { "compartment": "compartment_12045", "id": "reaction_10535108", "reactome": "R-CEL-1483186", "name": "PC is converted to PS by PTDSS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426925", "species_200736" ], "products": [ "species_264618", "species_1500646" ], "modifiers": [ [ "species_10535105", "catalyst" ] ], "additional_components": [ "WBGene00013920" ] }, "reaction_10534897": { "compartment": "compartment_12045", "id": "reaction_10534897", "reactome": "R-CEL-1482816", "name": "PC is hydrolyzed to 1-acyl LPC by PLA2[6]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_426925" ], "products": [ "species_1524028", "species_1524021" ], "modifiers": [ [ "species_10534894", "catalyst" ] ], "additional_components": [ "Q3V5J7", "WBGene00044468", "O16654", "WBGene00044468", "Q17790", "WBGene00044468", "species_74016", "Q8MXR3", "WBGene00022233" ] }, "reaction_10534753": { "compartment": "compartment_12045", "id": "reaction_10534753", "reactome": "R-CEL-1482547", "name": "1-acyl LPC is acylated to PC by LPCAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524028", "species_1500578" ], "products": [ "species_426925", "species_76194" ], "modifiers": [ [ "species_10534731", "catalyst" ] ], "additional_components": [ "O01925", "WBGene00020115", "G5EC53", "WBGene00016934" ] }, "reaction_10567209": { "compartment": "compartment_12045", "id": "reaction_10567209", "reactome": "R-CEL-8874435", "name": "THEM86B hydrolyses PMCHO, PMETAM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_8874447" ], "products": [ "species_8874450", "species_5696116" ], "modifiers": [ [ "species_10567206", "catalyst" ] ], "additional_components": [ "CHEBI:17810", "CHEBI:17476", "CHEBI:36313", "CHEBI:36314", "WBGene00010943" ] }, "reaction_10534907": { "compartment": "compartment_12045", "id": "reaction_10534907", "reactome": "R-CEL-1482856", "name": "PC is hydrolyzed to 1-acyl LPC by PLA2[5]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_426925" ], "products": [ "species_1524028", "species_1524021" ], "modifiers": [ [ "species_10534904", "catalyst" ] ], "additional_components": [ "WBGene00016661" ] }, "reaction_10535867": { "compartment": "compartment_984", "id": "reaction_10535867", "reactome": "R-CEL-1602399", "name": "PC is hydrolyzed to 1-acyl LPC by PLB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_429802" ], "products": [ "species_1602390", "species_1602366" ], "modifiers": [ [ "species_10530529", "catalyst" ] ], "additional_components": [ "Q8MXQ8", "WBGene00022256", "Q9N2Z4", "WBGene00022256" ] }, "reaction_10535869": { "compartment": "compartment_984", "id": "reaction_10535869", "reactome": "R-CEL-1602417", "name": "PC is hydrolyzed to 1-acyl LPC by PLA2[16]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_429802" ], "products": [ "species_1602390", "species_1602366" ], "modifiers": [ [ "species_10535837", "catalyst" ], [ "species_10535855", "inhibitor" ] ], "additional_components": [ "species_74016", "Q17790", "WBGene00044468", "O16654", "WBGene00044468", "Q3V5J7", "WBGene00044468", "Q18339", "WBGene00016288", "G4RY15", "WBGene00015631", "P34472", "WBGene00010228", "Q22591", "WBGene00020585" ] }, "reaction_10534734": { "compartment": "compartment_12045", "id": "reaction_10534734", "reactome": "R-CEL-1482533", "name": "2-acyl LPC is acylated to PC by LPCAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500578", "species_975614" ], "products": [ "species_426925", "species_76194" ], "modifiers": [ [ "species_10534731", "catalyst" ] ], "additional_components": [ "O01925", "WBGene00020115", "G5EC53", "WBGene00016934" ] }, "reaction_10534914": { "compartment": "compartment_12045", "id": "reaction_10534914", "reactome": "R-CEL-1482868", "name": "PI is hydrolyzed to 1-acyl LPI by PLA2[12]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_426639" ], "products": [ "species_1498733", "species_1524021" ], "modifiers": [ [ "species_10534852", "catalyst" ] ], "additional_components": [ "Q3V5J7", "WBGene00044468", "O16654", "WBGene00044468", "Q17790", "WBGene00044468", "species_74016" ] }, "reaction_10534789": { "compartment": "compartment_12045", "id": "reaction_10534789", "reactome": "R-CEL-1482626", "name": "2-acyl LPI is acylated to PI by MBOAT7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1498737", "species_1500578" ], "products": [ "species_426639", "species_76194" ], "modifiers": [ [ "species_10534763", "catalyst" ] ], "additional_components": [ "WBGene00008806" ] }, "reaction_10535862": { "compartment": "compartment_984", "id": "reaction_10535862", "reactome": "R-CEL-1602377", "name": "PI is hydrolyzed to 1-acyl LPI by PLA2[15]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_426658" ], "products": [ "species_1602420", "species_1602366" ], "modifiers": [ [ "species_10535837", "catalyst" ], [ "species_10535855", "inhibitor" ] ], "additional_components": [ "species_74016", "Q17790", "WBGene00044468", "O16654", "WBGene00044468", "Q3V5J7", "WBGene00044468", "Q18339", "WBGene00016288", "G4RY15", "WBGene00015631", "P34472", "WBGene00010228", "Q22591", "WBGene00020585" ] }, "reaction_10534766": { "compartment": "compartment_12045", "id": "reaction_10534766", "reactome": "R-CEL-1482598", "name": "1-acyl LPI is acylated to PI by MBOAT7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1498733", "species_1500578" ], "products": [ "species_426639", "species_76194" ], "modifiers": [ [ "species_10534763", "catalyst" ] ], "additional_components": [ "WBGene00008806" ] }, "reaction_10557548": { "compartment": "compartment_17906", "id": "reaction_10557548", "reactome": "R-CEL-5696074", "name": "AGK:Mg2+ phosphorylates MAG, DAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5696066", "species_5696069" ], "products": [ "species_5696026", "species_5696037" ], "modifiers": [ [ "species_10557545", "catalyst" ] ], "additional_components": [ "species_6814795", "species_114519", "species_1524101", "species_417891", "Q10123", "WBGene00018674", "species_114632" ] }, "reaction_10534916": { "compartment": "compartment_12045", "id": "reaction_10534916", "reactome": "R-CEL-1482884", "name": "PE is hydrolyzed to 1-acyl LPE by PLA2[2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1500581" ], "products": [ "species_1498738", "species_1524021" ], "modifiers": [ [ "species_10534904", "catalyst" ] ], "additional_components": [ "WBGene00016661" ] }, "reaction_10534918": { "compartment": "compartment_12045", "id": "reaction_10534918", "reactome": "R-CEL-1482887", "name": "PE is hydrolyzed to 1-acyl LPE by PLA2[3]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1500581" ], "products": [ "species_1498738", "species_1524021" ], "modifiers": [ [ "species_10534894", "catalyst" ] ], "additional_components": [ "Q3V5J7", "WBGene00044468", "O16654", "WBGene00044468", "Q17790", "WBGene00044468", "species_74016", "Q8MXR3", "WBGene00022233" ] }, "reaction_10535864": { "compartment": "compartment_984", "id": "reaction_10535864", "reactome": "R-CEL-1602398", "name": "PE is hydrolyzed to 1-acyl LPE by PLA2[16]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1602375", "species_109276" ], "products": [ "species_1602372", "species_1602366" ], "modifiers": [ [ "species_10535837", "catalyst" ], [ "species_10535855", "inhibitor" ] ], "additional_components": [ "species_74016", "Q17790", "WBGene00044468", "O16654", "WBGene00044468", "Q3V5J7", "WBGene00044468", "Q18339", "WBGene00016288", "G4RY15", "WBGene00015631", "P34472", "WBGene00010228", "Q22591", "WBGene00020585" ] }, "reaction_10557512": { "compartment": "compartment_70101", "id": "reaction_10557512", "reactome": "R-CEL-5694583", "name": "ABHD4 hydrolyses NAPE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5694568", "species_29356" ], "products": [ "species_5694580", "species_5694567" ], "modifiers": [ [ "species_10557509", "catalyst" ] ], "additional_components": [ "WBGene00007711" ] }, "reaction_10534842": { "compartment": "compartment_12045", "id": "reaction_10534842", "reactome": "R-CEL-1482667", "name": "1-acyl LPE is acylated to PE by LPEAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500578", "species_1498738" ], "products": [ "species_76194", "species_1500581" ], "modifiers": [ [ "species_10534808", "catalyst" ] ], "additional_components": [ "G5EC53", "WBGene00016934", "H9G2W5", "WBGene00007446", "O01925", "WBGene00020115" ] }, "reaction_10534811": { "compartment": "compartment_12045", "id": "reaction_10534811", "reactome": "R-CEL-1482646", "name": "2-acyl LPE is acylated to PE by LPEAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1498729", "species_1500578" ], "products": [ "species_76194", "species_1500581" ], "modifiers": [ [ "species_10534808", "catalyst" ] ], "additional_components": [ "G5EC53", "WBGene00016934", "H9G2W5", "WBGene00007446", "O01925", "WBGene00020115" ] }, "reaction_10534786": { "compartment": "compartment_17906", "id": "reaction_10534786", "reactome": "R-CEL-1482604", "name": "PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1500590" ], "products": [ "species_1500580", "species_1524103" ], "modifiers": [ [ "species_10534783", "catalyst" ] ], "additional_components": [ "O16654", "WBGene00044468", "Q17790", "WBGene00044468", "Q3V5J7", "WBGene00044468" ] }, "reaction_10534981": { "compartment": "compartment_70101", "id": "reaction_10534981", "reactome": "R-CEL-1483002", "name": "DHAP is converted to 1-acyl GO3P by GNPAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500578", "species_75970" ], "products": [ "species_75973", "species_76194" ], "modifiers": [ [ "species_10534978", "catalyst" ] ], "additional_components": [ "WBGene00012911" ] }, "reaction_10512710": { "compartment": "compartment_5460", "id": "reaction_10512710", "reactome": "R-CEL-188467", "name": "Gly-3-P+FAD->DHAP+FADH2 (catalyzed by mitochondrial Gly-Phos dehydrogenase)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113596", "species_188458" ], "products": [ "species_31649", "species_188451" ], "modifiers": [ [ "species_10512707", "catalyst" ] ], "additional_components": [ "WBGene00012031" ] }, "reaction_10534758": { "compartment": "compartment_17906", "id": "reaction_10534758", "reactome": "R-CEL-1482548", "name": "1-acyl LPA is acylated to PA by AGPAT5 (OM)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500578", "species_1500580" ], "products": [ "species_1500590", "species_76194" ], "modifiers": [ [ "species_10534755", "catalyst" ] ], "additional_components": [ "WBGene00017888" ] }, "reaction_10534839": { "compartment": "compartment_70101", "id": "reaction_10534839", "reactome": "R-CEL-1482656", "name": "PA is hydrolysed to 1-acyl LPA by PLA2[1]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_426755" ], "products": [ "species_1500604", "species_1524021" ], "modifiers": [ [ "species_10534783", "catalyst" ] ], "additional_components": [ "O16654", "WBGene00044468", "Q17790", "WBGene00044468", "Q3V5J7", "WBGene00044468" ] }, "reaction_10534855": { "compartment": "compartment_12045", "id": "reaction_10534855", "reactome": "R-CEL-1482679", "name": "PA is hydrolysed to 1-acyl LPA by PLA2G2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_426755" ], "products": [ "species_1500604", "species_1524021" ], "modifiers": [ [ "species_10534852", "catalyst" ] ], "additional_components": [ "Q3V5J7", "WBGene00044468", "O16654", "WBGene00044468", "Q17790", "WBGene00044468", "species_74016" ] }, "reaction_10507577": { "compartment": "compartment_70101", "id": "reaction_10507577", "reactome": "R-CEL-75889", "name": "DHAP is converted to G3P by GPD1/GPD1L", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_75970", "species_73473" ], "products": [ "species_76114", "species_29360" ], "modifiers": [ [ "species_10507574", "catalyst" ] ], "additional_components": [ "Q9XTS4", "WBGene00009824", "P34517", "WBGene00010778" ] }, "reaction_10527340": { "compartment": "compartment_12045", "id": "reaction_10527340", "reactome": "R-CEL-549112", "name": "G3P is acylated to 1-acyl LPA by AGPAT6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500578", "species_76114" ], "products": [ "species_1500604", "species_76194" ], "modifiers": [ [ "species_10507520", "catalyst" ] ], "additional_components": [ "G5EE59", "WBGene00010902", "Q21812", "WBGene00011106", "Q9N5S8", "WBGene00018657" ] }, "reaction_10507532": { "compartment": "compartment_12045", "id": "reaction_10507532", "reactome": "R-CEL-75885", "name": "1-acyl LPA is acylated to PA by AGPAT (LPAAT)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500604", "species_1500578" ], "products": [ "species_426755", "species_76194" ], "modifiers": [ [ "species_10507529", "catalyst" ] ], "additional_components": [ "G5EE59", "WBGene00010902", "Q21812", "WBGene00011106", "Q9N5S8", "WBGene00018657", "O16526", "WBGene00020264", "Q22267", "WBGene00011543", "Q93841", "WBGene00010339", "Q95R12", "WBGene00017888" ] }, "reaction_10535100": { "compartment": "compartment_12045", "id": "reaction_10535100", "reactome": "R-CEL-1483182", "name": "PC is hydrolyzed to PA and choline by PLD1/2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_426925" ], "products": [ "species_264618", "species_426755" ], "modifiers": [ [ "species_10535095", "catalyst" ] ], "additional_components": [ "WBGene00004040" ] }, "reaction_10534863": { "compartment": "compartment_17906", "id": "reaction_10534863", "reactome": "R-CEL-1482695", "name": "G3P is acylated to 1-acyl LPA by GPAM/GPAT2 (OM)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500578", "species_76114" ], "products": [ "species_76194", "species_1500580" ], "modifiers": [ [ "species_10507537", "catalyst" ] ], "additional_components": [ "WBGene00017261" ] }, "reaction_10535871": { "compartment": "compartment_984", "id": "reaction_10535871", "reactome": "R-CEL-1602446", "name": "PA is hydrolyzed to 1-acyl LPA by PLA2[15]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_1602448" ], "products": [ "species_1602447", "species_1602366" ], "modifiers": [ [ "species_10535837", "catalyst" ], [ "species_10535855", "inhibitor" ] ], "additional_components": [ "species_74016", "Q17790", "WBGene00044468", "O16654", "WBGene00044468", "Q3V5J7", "WBGene00044468", "Q18339", "WBGene00016288", "G4RY15", "WBGene00015631", "P34472", "WBGene00010228", "Q22591", "WBGene00020585" ] }, "reaction_10569180": { "compartment": "compartment_984", "id": "reaction_10569180", "reactome": "R-CEL-8952251", "name": "PLA2G15 hydrolyses LPC to GPCho and LCFA(-)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_2173763" ], "products": [ "species_8954142", "species_8952253" ], "modifiers": [ [ "species_10569177", "catalyst" ] ], "additional_components": [ "WBGene00010872" ] }, "reaction_10534976": { "compartment": "compartment_12045", "id": "reaction_10534976", "reactome": "R-CEL-1482976", "name": "CDP-DAG is converted to PI by CDIPT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426955", "species_426910" ], "products": [ "species_426639", "species_109395" ], "modifiers": [ [ "species_10534973", "catalyst" ] ], "additional_components": [ "species_114632", "species_266099", "Q9U2G1", "WBGene00012897" ] }, "reaction_10535085": { "compartment": "compartment_12045", "id": "reaction_10535085", "reactome": "R-CEL-1483121", "name": "PA is converted to CDP-DAG by CDS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_110614", "species_426755" ], "products": [ "species_111294", "species_426955" ], "modifiers": [ [ "species_10535082", "catalyst" ] ], "additional_components": [ "species_114632", "P53439", "WBGene00016384" ] }, "reaction_10566702": { "compartment": "compartment_70101", "id": "reaction_10566702", "reactome": "R-CEL-8869241", "name": "PITPNM1,2,3 exchange PI for PA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426639", "species_1602448" ], "products": [ "species_426755", "species_426658" ], "modifiers": [ [ "species_10566697", "catalyst" ] ], "additional_components": [ "WBGene00010813" ] }, "reaction_10535034": { "compartment": "compartment_70616", "id": "reaction_10535034", "reactome": "R-CEL-1483063", "name": "PG and CDP-DAG are converted to CL by CRLS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524042", "species_1524064" ], "products": [ "species_1524072", "species_1524067" ], "modifiers": [ [ "species_10534747", "catalyst" ] ], "additional_components": [ "WBGene00017763" ] }, "reaction_10535057": { "compartment": "compartment_12045", "id": "reaction_10535057", "reactome": "R-CEL-1483081", "name": "PCho and CTP are condensed to CDP-Cho by PCYT1 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_110614", "species_1524071" ], "products": [ "species_111294", "species_1524060" ], "modifiers": [ [ "species_10535054", "catalyst" ] ], "additional_components": [ "Q8IU09", "WBGene00021215", "P49583", "WBGene00017241" ] }, "reaction_10534947": { "compartment": "compartment_12045", "id": "reaction_10534947", "reactome": "R-CEL-1482961", "name": "CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524060", "species_1500596" ], "products": [ "species_426925", "species_109395" ], "modifiers": [ [ "species_10534944", "catalyst" ] ], "additional_components": [ "species_114632", "species_266099", "G5EC09", "WBGene00009057", "G5EC25", "WBGene00013024" ] }, "reaction_10534966": { "compartment": "compartment_20699", "id": "reaction_10534966", "reactome": "R-CEL-1482973", "name": "CDP-Cho and DAG are converted to PC by CHPT1 at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524057", "species_1524060" ], "products": [ "species_429785", "species_109395" ], "modifiers": [ [ "species_10534963", "catalyst" ] ], "additional_components": [ "species_114632", "species_266099", "G5EC25", "WBGene00013024" ] }, "reaction_10535031": { "compartment": "compartment_70101", "id": "reaction_10535031", "reactome": "R-CEL-1483004", "name": "Cho is phosphorylated to PCho by CHK dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_264618", "species_113592" ], "products": [ "species_29370", "species_1524071" ], "modifiers": [ [ "species_10535028", "catalyst" ] ], "additional_components": [ "P46560", "WBGene00000513", "O17610", "WBGene00000509", "Q22820", "WBGene00000515", "P46558", "WBGene00000511", "Q22942", "WBGene00000510", "P46559", "WBGene00000512", "Q9GZF3", "WBGene00000514" ] }, "reaction_10557483": { "compartment": "compartment_876", "id": "reaction_10557483", "reactome": "R-CEL-5694485", "name": "ABHD3 hydrolyses LPC(14:0) to 1AGPC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_5694502" ], "products": [ "species_5694457", "species_1861754" ], "modifiers": [ [ "species_10557480", "catalyst" ] ], "additional_components": [ "Q18610", "WBGene00016644", "Q9U1Z6", "WBGene00013358" ] }, "reaction_10567146": { "compartment": "compartment_70101", "id": "reaction_10567146", "reactome": "R-CEL-8873929", "name": "Casein kinase II phosphorylates STARD10", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10567141" ], "products": [ "species_29370", "species_10567144" ], "modifiers": [ [ "species_10515097", "catalyst" ] ], "additional_components": [ "WBGene00012127", "WBGene00012127", "P18334", "WBGene00002191", "P28548", "WBGene00002196" ] }, "reaction_10518395": { "compartment": "compartment_984", "id": "reaction_10518395", "reactome": "R-CEL-372519", "name": "AcCho is hydrolyzed to Cho and acetate by ACHE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_372533" ], "products": [ "species_1524044", "species_264638" ], "modifiers": [ [ "species_10518390", "catalyst" ], [ "species_10518393", "inhibitor" ] ], "additional_components": [ "Q23268", "WBGene00013873", "Q04457", "WBGene00001578", "H9G2Y9", "WBGene00013874", "A0A1C3NSL8", "WBGene00017478", "Q4LDP0", "WBGene00020891", "Q21266", "WBGene00019477", "O01302", "WBGene00011362", "G5EDJ7", "WBGene00013875", "Q9XW75", "WBGene00013540", "Q22008", "WBGene00020125", "P92016", "WBGene00011364", "H2L0K7", "WBGene00020330", "Q23268", "WBGene00013873", "Q04457", "WBGene00001578", "H9G2Y9", "WBGene00013874", "A0A1C3NSL8", "WBGene00017478", "Q4LDP0", "WBGene00020891", "Q21266", "WBGene00019477", "O01302", "WBGene00011362", "G5EDJ7", "WBGene00013875", "Q9XW75", "WBGene00013540", "Q22008", "WBGene00020125", "P92016", "WBGene00011364", "H2L0K7", "WBGene00020330" ] }, "reaction_10567581": { "compartment": "compartment_12045", "id": "reaction_10567581", "reactome": "R-CEL-8877153", "name": "STARD7 binds PC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426925", "species_10567577" ], "products": [ "species_10567579" ], "modifiers": [], "additional_components": [ "WBGene00007386", "Q17764", "WBGene00007386", "species_194276" ] }, "reaction_10535075": { "compartment": "compartment_20699", "id": "reaction_10535075", "reactome": "R-CEL-1483087", "name": "PI is exchanged with PC by PITPNB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_429785", "species_10535071" ], "products": [ "species_1524146", "species_10535073" ], "modifiers": [], "additional_components": [ "species_426639", "Q95XP0", "WBGene00022155", "Q965T2", "WBGene00022155", "Q95XP0", "WBGene00022155", "Q965T2", "WBGene00022155", "species_194276" ] }, "reaction_10535139": { "compartment": "compartment_20699", "id": "reaction_10535139", "reactome": "R-CEL-1483211", "name": "PC:PITPNB is transported from the Golgi membrane to the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10535073" ], "products": [ "species_10535137" ], "modifiers": [], "additional_components": [ "Q95XP0", "WBGene00022155", "Q965T2", "WBGene00022155", "species_194276", "species_194276", "Q95XP0", "WBGene00022155", "Q965T2", "WBGene00022155" ] }, "reaction_10535148": { "compartment": "compartment_12045", "id": "reaction_10535148", "reactome": "R-CEL-1483229", "name": "PI:PITPNB is transported from the ER membrane to the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10535141" ], "products": [ "species_10535071" ], "modifiers": [], "additional_components": [ "species_426639", "Q95XP0", "WBGene00022155", "Q965T2", "WBGene00022155", "species_426639", "Q95XP0", "WBGene00022155", "Q965T2", "WBGene00022155" ] }, "reaction_10507366": { "compartment": "compartment_7660", "id": "reaction_10507366", "reactome": "R-CEL-75172", "name": "Formation of RAD50:MRE11 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10507357", "species_10507362" ], "products": [ "species_10507364" ], "modifiers": [], "additional_components": [ "WBGene00004296", "WBGene00003405", "Q23255", "WBGene00003405", "O44199", "WBGene00004296" ] }, "reaction_10571888": { "compartment": "compartment_70101", "id": "reaction_10571888", "reactome": "R-CEL-9603804", "name": "PEX19 binds class I peroxisomal membrane proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10571868", "species_10520426" ], "products": [ "species_10571870" ], "modifiers": [], "additional_components": [ "A0A486WWU7", "WBGene00000110", "O44555", "WBGene00000111", "Q93930", "WBGene00004199", "P54815", "WBGene00010557", "Q7YWV6", "WBGene00011826", "O45730", "WBGene00004061", "Q6AHP8", "WBGene00001425", "P91262", "WBGene00017574", "Q19189", "WBGene00004197", "Q18598", "WBGene00004059", "A0A1D3PCN1", "WBGene00270319", "Q9XTZ5", "WBGene00007680", "Q19951", "WBGene00004198", "WBGene00004201", "P34453", "WBGene00004201", "A0A486WWU7", "WBGene00000110", "O44555", "WBGene00000111", "Q93930", "WBGene00004199", "P54815", "WBGene00010557", "Q7YWV6", "WBGene00011826", "O45730", "WBGene00004061", "Q6AHP8", "WBGene00001425", "P91262", "WBGene00017574", "Q19189", "WBGene00004197", "Q18598", "WBGene00004059", "A0A1D3PCN1", "WBGene00270319", "Q9XTZ5", "WBGene00007680", "Q19951", "WBGene00004198" ] }, "reaction_10571884": { "compartment": "compartment_17947", "id": "reaction_10571884", "reactome": "R-CEL-9603775", "name": "PEX3:PEX19:class I PMP dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10571872" ], "products": [ "species_10571882", "species_10520426", "species_10520404" ], "modifiers": [], "additional_components": [ "Q18028", "WBGene00004193", "P34453", "WBGene00004201", "A0A486WWU7", "WBGene00000110", "O44555", "WBGene00000111", "Q93930", "WBGene00004199", "P54815", "WBGene00010557", "Q7YWV6", "WBGene00011826", "O45730", "WBGene00004061", "Q6AHP8", "WBGene00001425", "P91262", "WBGene00017574", "Q19189", "WBGene00004197", "Q18598", "WBGene00004059", "A0A1D3PCN1", "WBGene00270319", "Q9XTZ5", "WBGene00007680", "Q19951", "WBGene00004198", "A0A1D3PCN1", "WBGene00270319", "Q9XTZ5", "WBGene00007680", "Q19951", "WBGene00004198", "P54815", "WBGene00010557", "O44555", "WBGene00000111", "A0A486WWU7", "WBGene00000110", "Q93930", "WBGene00004199", "Q6AHP8", "WBGene00001425", "Q18598", "WBGene00004059", "Q19189", "WBGene00004197", "Q7YWV6", "WBGene00011826", "P91262", "WBGene00017574", "O45730", "WBGene00004061", "WBGene00004201", "WBGene00004193" ] }, "reaction_10571886": { "compartment": "compartment_17947", "id": "reaction_10571886", "reactome": "R-CEL-9603784", "name": "PEX19:class I PMP binds PEX3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10571870", "species_10520404" ], "products": [ "species_10571872" ], "modifiers": [], "additional_components": [ "P34453", "WBGene00004201", "A0A486WWU7", "WBGene00000110", "O44555", "WBGene00000111", "Q93930", "WBGene00004199", "P54815", "WBGene00010557", "Q7YWV6", "WBGene00011826", "O45730", "WBGene00004061", "Q6AHP8", "WBGene00001425", "P91262", "WBGene00017574", "Q19189", "WBGene00004197", "Q18598", "WBGene00004059", "A0A1D3PCN1", "WBGene00270319", "Q9XTZ5", "WBGene00007680", "Q19951", "WBGene00004198", "WBGene00004193", "Q18028", "WBGene00004193", "P34453", "WBGene00004201", "A0A486WWU7", "WBGene00000110", "O44555", "WBGene00000111", "Q93930", "WBGene00004199", "P54815", "WBGene00010557", "Q7YWV6", "WBGene00011826", "O45730", "WBGene00004061", "Q6AHP8", "WBGene00001425", "P91262", "WBGene00017574", "Q19189", "WBGene00004197", "Q18598", "WBGene00004059", "A0A1D3PCN1", "WBGene00270319", "Q9XTZ5", "WBGene00007680", "Q19951", "WBGene00004198" ] }, "reaction_10551384": { "compartment": "compartment_70101", "id": "reaction_10551384", "reactome": "R-CEL-5334794", "name": "FABPs bind LCFAs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8876730", "species_10551380" ], "products": [ "species_10551382" ], "modifiers": [], "additional_components": [ "O02324", "WBGene00002260", "O01812", "WBGene00002258", "O01814", "WBGene00002257", "O02323", "WBGene00002259", "Q965W1", "WBGene00021486", "O02324", "WBGene00002260", "O01812", "WBGene00002258", "O01814", "WBGene00002257", "O02323", "WBGene00002259", "Q965W1", "WBGene00021486", "species_8876730" ] }, "reaction_10564685": { "compartment": "compartment_70101", "id": "reaction_10564685", "reactome": "R-CEL-8848339", "name": "PNPLA5 hydrolyzes TAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_549167" ], "products": [ "species_8876730", "species_76103" ], "modifiers": [ [ "species_10564682", "catalyst" ] ], "additional_components": [ "Q11186", "WBGene00015484", "Q18948", "WBGene00015241", "Q9N5Z7", "WBGene00015241" ] }, "reaction_10571751": { "compartment": "compartment_17947", "id": "reaction_10571751", "reactome": "R-CEL-9033485", "name": "PEX2:PEX10:PEX12 monoubiquitinates PEX5L at cysteine-11", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10571746" ], "products": [ "species_10532186", "species_10571748" ], "modifiers": [ [ "species_10571746", "catalyst" ] ], "additional_components": [ "Q19951", "WBGene00004198", "Q93930", "WBGene00004199", "Q18355", "WBGene00016318", "Q19189", "WBGene00004197", "Q18426", "WBGene00004194", "P35129", "WBGene00002344", "P91853", "WBGene00006732", "Q17720", "WBGene00006717", "Q20617", "WBGene00006719", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "P35129", "WBGene00002344", "P91853", "WBGene00006732", "Q17720", "WBGene00006717", "Q20617", "WBGene00006719", "Q19951", "WBGene00004198", "Q93930", "WBGene00004199", "Q18355", "WBGene00016318", "Q19189", "WBGene00004197", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "Q18426", "WBGene00004194", "Q19951", "WBGene00004198", "Q93930", "WBGene00004199", "Q18355", "WBGene00016318", "Q19189", "WBGene00004197", "Q18426", "WBGene00004194", "P35129", "WBGene00002344", "P91853", "WBGene00006732", "Q17720", "WBGene00006717", "Q20617", "WBGene00006719", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727" ] }, "reaction_10571738": { "compartment": "compartment_17947", "id": "reaction_10571738", "reactome": "R-CEL-9033235", "name": "Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10571710" ], "products": [ "species_10569900", "species_10571736" ], "modifiers": [], "additional_components": [ "Q18122", "WBGene00016034", "O16249", "WBGene00018426", "Q17499", "WBGene00007175", "A0A486WVT5", "WBGene00011850", "Q9BIA9", "WBGene00015887", "Q9XW87", "WBGene00013541", "P91148", "WBGene00003584", "G5EGA6", "WBGene00010063", "B3WFZ3", "WBGene00020989", "O01862", "WBGene00020989", "O45003", "WBGene00020989", "Q9GYN3", "WBGene00020989", "Q8MYL7", "WBGene00013220", "O01739", "WBGene00017648", "O45307", "WBGene00008127", "Q19564", "WBGene00017565", "Q95XG9", "WBGene00022076", "B1GRK5", "WBGene00018286", "O62138", "WBGene00008566", "Q18916", "WBGene00017012", "Q19878", "WBGene00009218", "G5EFP8", "WBGene00012911", "H9G2T4", "WBGene00010317", "Q94055", "WBGene00011767", "Q18006", "WBGene00015783", "Q18973", "WBGene00017054", "O76383", "WBGene00016061", "Q93839", "WBGene00010336", "O62137", "WBGene00008565", "O62139", "WBGene00008567", "O62140", "WBGene00008564", "P34355", "WBGene00008167", "Q20048", "WBGene00009439", "Q20992", "WBGene00019060", "Q95XN1", "WBGene00022150", "O17761", "WBGene00001157", "Q19058", "WBGene00017123", "Q20959", "WBGene00019022", "Q9NA25", "WBGene00003585", "Q17474", "WBGene00007143", "Q18426", "WBGene00004194", "Q19951", "WBGene00004198", "Q93930", "WBGene00004199", "Q18355", "WBGene00016318", "Q19189", "WBGene00004197", "Q19951", "WBGene00004198", "Q93930", "WBGene00004199", "Q18355", "WBGene00016318", "Q19189", "WBGene00004197", "Q18426", "WBGene00004194", "O76383", "WBGene00016061", "Q20992", "WBGene00019060", "B3WFZ3", "WBGene00020989", "O01862", "WBGene00020989", "O45003", "WBGene00020989", "Q9GYN3", "WBGene00020989", "Q9BIA9", "WBGene00015887", "Q17474", "WBGene00007143", "Q95XG9", "WBGene00022076", "Q19058", "WBGene00017123", "O17761", "WBGene00001157", "Q20048", "WBGene00009439", "O62138", "WBGene00008566", "Q18006", "WBGene00015783", "B1GRK5", "WBGene00018286", "Q18916", "WBGene00017012", "Q19878", "WBGene00009218", "Q20959", "WBGene00019022", "G5EFP8", "WBGene00012911", "A0A486WVT5", "WBGene00011850", "Q19564", "WBGene00017565", "O01739", "WBGene00017648", "O45307", "WBGene00008127", "Q18973", "WBGene00017054", "Q17499", "WBGene00007175", "Q95XN1", "WBGene00022150", "Q94055", "WBGene00011767", "Q9NA25", "WBGene00003585", "H9G2T4", "WBGene00010317", "O16249", "WBGene00018426", "Q9XW87", "WBGene00013541", "G5EGA6", "WBGene00010063", "P34355", "WBGene00008167", "Q93839", "WBGene00010336", "O62139", "WBGene00008567", "O62140", "WBGene00008564", "O62137", "WBGene00008565", "Q18122", "WBGene00016034", "P91148", "WBGene00003584", "Q8MYL7", "WBGene00013220" ] }, "reaction_10571740": { "compartment": "compartment_17947", "id": "reaction_10571740", "reactome": "R-CEL-9033236", "name": "PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10571708", "species_10571706" ], "products": [ "species_10571710" ], "modifiers": [], "additional_components": [ "Q19951", "WBGene00004198", "Q93930", "WBGene00004199", "Q18355", "WBGene00016318", "Q19189", "WBGene00004197", "Q18122", "WBGene00016034", "O16249", "WBGene00018426", "Q17499", "WBGene00007175", "A0A486WVT5", "WBGene00011850", "Q9BIA9", "WBGene00015887", "Q9XW87", "WBGene00013541", "P91148", "WBGene00003584", "G5EGA6", "WBGene00010063", "B3WFZ3", "WBGene00020989", "O01862", "WBGene00020989", "O45003", "WBGene00020989", "Q9GYN3", "WBGene00020989", "Q8MYL7", "WBGene00013220", "O01739", "WBGene00017648", "O45307", "WBGene00008127", "Q19564", "WBGene00017565", "Q95XG9", "WBGene00022076", "B1GRK5", "WBGene00018286", "O62138", "WBGene00008566", "Q18916", "WBGene00017012", "Q19878", "WBGene00009218", "G5EFP8", "WBGene00012911", "H9G2T4", "WBGene00010317", "Q94055", "WBGene00011767", "Q18006", "WBGene00015783", "Q18973", "WBGene00017054", "O76383", "WBGene00016061", "Q93839", "WBGene00010336", "O62137", "WBGene00008565", "O62139", "WBGene00008567", "O62140", "WBGene00008564", "P34355", "WBGene00008167", "Q20048", "WBGene00009439", "Q20992", "WBGene00019060", "Q95XN1", "WBGene00022150", "O17761", "WBGene00001157", "Q19058", "WBGene00017123", "Q20959", "WBGene00019022", "Q9NA25", "WBGene00003585", "Q17474", "WBGene00007143", "Q18426", "WBGene00004194", "Q18122", "WBGene00016034", "O16249", "WBGene00018426", "Q17499", "WBGene00007175", "A0A486WVT5", "WBGene00011850", "Q9BIA9", "WBGene00015887", "Q9XW87", "WBGene00013541", "P91148", "WBGene00003584", "G5EGA6", "WBGene00010063", "B3WFZ3", "WBGene00020989", "O01862", "WBGene00020989", "O45003", "WBGene00020989", "Q9GYN3", "WBGene00020989", "Q8MYL7", "WBGene00013220", "O01739", "WBGene00017648", "O45307", "WBGene00008127", "Q19564", "WBGene00017565", "Q95XG9", "WBGene00022076", "B1GRK5", "WBGene00018286", "O62138", "WBGene00008566", "Q18916", "WBGene00017012", "Q19878", "WBGene00009218", "G5EFP8", "WBGene00012911", "H9G2T4", "WBGene00010317", "Q94055", "WBGene00011767", "Q18006", "WBGene00015783", "Q18973", "WBGene00017054", "O76383", "WBGene00016061", "Q93839", "WBGene00010336", "O62137", "WBGene00008565", "O62139", "WBGene00008567", "O62140", "WBGene00008564", "P34355", "WBGene00008167", "Q20048", "WBGene00009439", "Q20992", "WBGene00019060", "Q95XN1", "WBGene00022150", "O17761", "WBGene00001157", "Q19058", "WBGene00017123", "Q20959", "WBGene00019022", "Q9NA25", "WBGene00003585", "Q17474", "WBGene00007143", "Q18426", "WBGene00004194", "Q19951", "WBGene00004198", "Q93930", "WBGene00004199", "Q18355", "WBGene00016318", "Q19189", "WBGene00004197" ] }, "reaction_10572195": { "compartment": "compartment_70101", "id": "reaction_10572195", "reactome": "R-CEL-9617595", "name": "SGTA binds mislocalized membrane protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10572191", "species_10571993" ], "products": [ "species_10572193" ], "modifiers": [], "additional_components": [ "Q19767", "WBGene00004898", "Q94057", "WBGene00044062", "Q95XH1", "WBGene00022077", "G5EBK2", "WBGene00014084", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q10651", "WBGene00000149", "Q21746", "WBGene00019893", "Q21746", "WBGene00019893", "Q19767", "WBGene00004898", "Q94057", "WBGene00044062", "Q95XH1", "WBGene00022077", "G5EBK2", "WBGene00014084", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q10651", "WBGene00000149" ] }, "reaction_10572045": { "compartment": "compartment_70101", "id": "reaction_10572045", "reactome": "R-CEL-9609921", "name": "SGTA binds Tail-anchored protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10572041", "species_10571993" ], "products": [ "species_10572043" ], "modifiers": [], "additional_components": [ "A0A486WWU7", "WBGene00000110", "O44555", "WBGene00000111", "Q93838", "WBGene00010337", "Q8MXH3", "WBGene00020374", "Q95XS2", "WBGene00021427", "O16000", "WBGene00006798", "Q19767", "WBGene00004898", "Q94057", "WBGene00044062", "Q95XH1", "WBGene00022077", "G5EBK2", "WBGene00014084", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q19967", "WBGene00001303", "Q20797", "WBGene00006373", "O01816", "WBGene00020931", "Q93315", "WBGene00007848", "A0A2K5ATR7", "WBGene00022450", "Q21746", "WBGene00019893", "Q21746", "WBGene00019893", "A0A486WWU7", "WBGene00000110", "O44555", "WBGene00000111", "Q93838", "WBGene00010337", "Q8MXH3", "WBGene00020374", "Q95XS2", "WBGene00021427", "O16000", "WBGene00006798", "Q19767", "WBGene00004898", "Q94057", "WBGene00044062", "Q95XH1", "WBGene00022077", "G5EBK2", "WBGene00014084", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q19967", "WBGene00001303", "Q20797", "WBGene00006373", "O01816", "WBGene00020931", "Q93315", "WBGene00007848", "A0A2K5ATR7", "WBGene00022450" ] }, "reaction_10528387": { "compartment": "compartment_876", "id": "reaction_10528387", "reactome": "R-CEL-888589", "name": "Release of GABA at the synapse", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74016", "species_10528368" ], "products": [ "species_10516825", "species_10516809", "species_10516744", "species_10516631", "species_10516823", "species_10528374", "species_352003", "species_10528372", "species_10516754", "species_10528370", "species_10528384" ], "modifiers": [ [ "species_10528368", "catalyst" ] ], "additional_components": [ "Q22366", "WBGene00006750", "G5EEN8", "WBGene00006454", "A5PEW5", "WBGene00004364", "P34815", "WBGene00006757", "Q9GUM7", "WBGene00022271", "O16000", "WBGene00006798", "G5EDB7", "WBGene00006762", "E5QCE7", "WBGene00001032", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q19767", "WBGene00004898", "Q94057", "WBGene00044062", "Q95XH1", "WBGene00022077", "G5EBK2", "WBGene00014084", "P09446", "WBGene00002005", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "Q94986", "WBGene00004267", "species_352003", "P34579", "WBGene00006783", "WBGene00004267", "species_74016", "G5EEN8", "WBGene00006454", "A5PEW5", "WBGene00004364", "Q94057", "WBGene00044062", "Q95XH1", "WBGene00022077", "G5EBK2", "WBGene00014084", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q19767", "WBGene00004898", "O16000", "WBGene00006798", "WBGene00022271", "WBGene00006757", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "WBGene00002005", "WBGene00001032", "WBGene00006750", "WBGene00006783", "G5EDB7", "WBGene00006762", "Q22366", "WBGene00006750", "G5EEN8", "WBGene00006454", "A5PEW5", "WBGene00004364", "P34815", "WBGene00006757", "Q9GUM7", "WBGene00022271", "O16000", "WBGene00006798", "G5EDB7", "WBGene00006762", "E5QCE7", "WBGene00001032", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q19767", "WBGene00004898", "Q94057", "WBGene00044062", "Q95XH1", "WBGene00022077", "G5EBK2", "WBGene00014084", "P09446", "WBGene00002005", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "Q94986", "WBGene00004267", "species_352003", "P34579", "WBGene00006783" ] }, "reaction_10528390": { "compartment": "compartment_70101", "id": "reaction_10528390", "reactome": "R-CEL-888592", "name": "Loading of GABA into clathrin sculpted GABA transport vesicle lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352011" ], "products": [ "species_428571" ], "modifiers": [ [ "species_10528334", "catalyst" ] ], "additional_components": [ "WBGene00006783" ] }, "reaction_10529192": { "compartment": "compartment_917758", "id": "reaction_10529192", "reactome": "R-CEL-917744", "name": "GABA loaded synaptic vesicle Docking and Priming", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10528366", "species_10516749", "species_10516744", "species_10516631", "species_10516739", "species_10516754" ], "products": [ "species_10528368" ], "modifiers": [ [ "species_10528366", "catalyst" ] ], "additional_components": [ "G5EDB7", "WBGene00006762", "E5QCE7", "WBGene00001032", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q19767", "WBGene00004898", "Q94057", "WBGene00044062", "Q95XH1", "WBGene00022077", "G5EBK2", "WBGene00014084", "P09446", "WBGene00002005", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "Q94986", "WBGene00004267", "species_352003", "P34579", "WBGene00006783", "WBGene00006798", "WBGene00022271", "WBGene00006757", "G5EEN8", "WBGene00006454", "A5PEW5", "WBGene00004364", "WBGene00006750", "Q22366", "WBGene00006750", "G5EEN8", "WBGene00006454", "A5PEW5", "WBGene00004364", "P34815", "WBGene00006757", "Q9GUM7", "WBGene00022271", "O16000", "WBGene00006798", "G5EDB7", "WBGene00006762", "E5QCE7", "WBGene00001032", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q19767", "WBGene00004898", "Q94057", "WBGene00044062", "Q95XH1", "WBGene00022077", "G5EBK2", "WBGene00014084", "P09446", "WBGene00002005", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "Q94986", "WBGene00004267", "species_352003", "P34579", "WBGene00006783", "G5EDB7", "WBGene00006762", "E5QCE7", "WBGene00001032", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q19767", "WBGene00004898", "Q94057", "WBGene00044062", "Q95XH1", "WBGene00022077", "G5EBK2", "WBGene00014084", "P09446", "WBGene00002005", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "Q94986", "WBGene00004267", "species_352003", "P34579", "WBGene00006783" ] }, "reaction_10528325": { "compartment": "compartment_917757", "id": "reaction_10528325", "reactome": "R-CEL-888577", "name": "Synthesis of GABA by GAD2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29404", "species_70106" ], "products": [ "species_352011", "species_113528" ], "modifiers": [ [ "species_10528322", "catalyst" ] ], "additional_components": [ "G5EDB7", "WBGene00006762" ] }, "reaction_10528313": { "compartment": "compartment_70101", "id": "reaction_10528313", "reactome": "R-CEL-888572", "name": "PXLP-K405-GAD1 decarboxylates L-Glu to form GABA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29404", "species_70106" ], "products": [ "species_352011", "species_113528" ], "modifiers": [ [ "species_10528310", "catalyst" ] ], "additional_components": [ "G5EDB7", "WBGene00006762" ] }, "reaction_10511628": { "compartment": "compartment_70101", "id": "reaction_10511628", "reactome": "R-CEL-174124", "name": "Dephosphorylation of phospho-Cdh1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10511618" ], "products": [ "species_111294", "species_10511606" ], "modifiers": [ [ "species_10511625", "catalyst" ] ], "additional_components": [ "WBGene00001510", "WBGene00001510" ] }, "reaction_10563824": { "compartment": "compartment_70101", "id": "reaction_10563824", "reactome": "R-CEL-6810843", "name": "Envoplakin binds periplakin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10563820", "species_10563818" ], "products": [ "species_10563822" ], "modifiers": [], "additional_components": [ "WBGene00006876", "WBGene00006876", "A0A1N7SYP3", "WBGene00006876" ] }, "reaction_10564246": { "compartment": "compartment_876", "id": "reaction_10564246", "reactome": "R-CEL-6814187", "name": "EVL:PPL heterodimer binds the inner surface of the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10563822", "species_983438" ], "products": [ "species_10563826" ], "modifiers": [], "additional_components": [ "A0A1N7SYP3", "WBGene00006876", "A0A1N7SYP3", "WBGene00006876" ] }, "reaction_10564473": { "compartment": "compartment_876", "id": "reaction_10564473", "reactome": "R-CEL-6814695", "name": "PERP binds desmosomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10564455", "species_10564469" ], "products": [ "species_10564471" ], "modifiers": [], "additional_components": [ "WBGene00006875", "Q19319", "WBGene00000396", "A0A1N7SYP3", "WBGene00006876", "Q10953", "WBGene00006943", "Q18825", "WBGene00000238", "O44326", "WBGene00001979", "Q9U308", "WBGene00002175", "Q19319", "WBGene00000396", "A0A1N7SYP3", "WBGene00006876", "Q10953", "WBGene00006943", "Q18825", "WBGene00000238", "O44326", "WBGene00001979", "Q9U308", "WBGene00002175", "G5ED30", "WBGene00006875" ] }, "reaction_10558492": { "compartment": "compartment_984", "id": "reaction_10558492", "reactome": "R-CEL-6789310", "name": "LIPs hydrolyse TG to DAG and RCOOH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_171126" ], "products": [ "species_174675", "species_6789319" ], "modifiers": [ [ "species_10558489", "catalyst" ] ], "additional_components": [ "O16956", "WBGene00020016", "Q20449", "WBGene00009773", "Q93789", "WBGene00010062", "O17766", "WBGene00008510", "O61866", "WBGene00022642", "Q94252", "WBGene00019376", "E2S7J2", "WBGene00021963", "Q9U276", "WBGene00013050" ] }, "reaction_10571492": { "compartment": "compartment_70101", "id": "reaction_10571492", "reactome": "R-CEL-9020270", "name": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_9024577" ], "products": [ "species_9024570" ], "modifiers": [ [ "species_10517863", "catalyst" ] ], "additional_components": [ "CHEBI:138615", "CHEBI:138616", "species_216785", "G5EFT4", "WBGene00016589" ] }, "reaction_10571494": { "compartment": "compartment_70101", "id": "reaction_10571494", "reactome": "R-CEL-9020271", "name": "GPX4-2 reduces 17(R)-Hp-DHA to 17(R)-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29450", "species_9024522" ], "products": [ "species_29356", "species_9024463", "species_111745" ], "modifiers": [ [ "species_10571475", "catalyst" ] ], "additional_components": [ "WBGene00019846" ] }, "reaction_10571484": { "compartment": "compartment_70101", "id": "reaction_10571484", "reactome": "R-CEL-9020252", "name": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_9024602" ], "products": [ "species_9024574" ], "modifiers": [ [ "species_10517863", "catalyst" ] ], "additional_components": [ "CHEBI:138179", "CHEBI:138614", "species_216785", "G5EFT4", "WBGene00016589" ] }, "reaction_10571490": { "compartment": "compartment_70101", "id": "reaction_10571490", "reactome": "R-CEL-9020258", "name": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_9024768" ], "products": [ "species_9024759" ], "modifiers": [ [ "species_10517863", "catalyst" ] ], "additional_components": [ "CHEBI:81565", "CHEBI:81564", "species_216785", "G5EFT4", "WBGene00016589" ] }, "reaction_10571496": { "compartment": "compartment_70101", "id": "reaction_10571496", "reactome": "R-CEL-9020273", "name": "GPX4-2 reduces 17(S)-Hp-DHA to 17(S)-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29450", "species_9024012" ], "products": [ "species_29356", "species_9024815", "species_111745" ], "modifiers": [ [ "species_10571475", "catalyst" ] ], "additional_components": [ "WBGene00019846" ] }, "reaction_10571486": { "compartment": "compartment_70101", "id": "reaction_10571486", "reactome": "R-CEL-9020253", "name": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(S)-HDHA to RvD3 or RvD4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_9024781" ], "products": [ "species_9024809" ], "modifiers": [ [ "species_10517863", "catalyst" ] ], "additional_components": [ "CHEBI:138649", "CHEBI:138648", "species_216785", "G5EFT4", "WBGene00016589" ] }, "reaction_10571488": { "compartment": "compartment_70101", "id": "reaction_10571488", "reactome": "R-CEL-9020257", "name": "LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_9024893" ], "products": [ "species_9024879" ], "modifiers": [ [ "species_10517863", "catalyst" ] ], "additional_components": [ "species_216785", "G5EFT4", "WBGene00016589" ] }, "reaction_10571541": { "compartment": "compartment_70101", "id": "reaction_10571541", "reactome": "R-CEL-9024890", "name": "LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_9024873" ], "products": [ "species_9024886" ], "modifiers": [ [ "species_10517863", "catalyst" ] ], "additional_components": [ "species_216785", "G5EFT4", "WBGene00016589" ] }, "reaction_10555584": { "compartment": "compartment_7660", "id": "reaction_10555584", "reactome": "R-CEL-5683792", "name": "p-T68-CHEK2 autophosphorylates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10555579" ], "products": [ "species_113582", "species_10502800" ], "modifiers": [ [ "species_10555579", "catalyst" ] ], "additional_components": [ "Q9U1Y5", "WBGene00000499", "WBGene00000499", "Q9U1Y5", "WBGene00000499" ] }, "reaction_10555635": { "compartment": "compartment_7660", "id": "reaction_10555635", "reactome": "R-CEL-5683964", "name": "ATM phosphorylates EYA1-4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10555610" ], "products": [ "species_113582", "species_10555619" ], "modifiers": [ [ "species_10555632", "catalyst" ] ], "additional_components": [ "WBGene00001377", "WBGene00001377", "Q9TYU5", "WBGene00007029", "Q23255", "WBGene00003405", "O44199", "WBGene00004296", "P62784", "WBGene00001875", "Q19649", "WBGene00017638", "Q23429", "WBGene00014240" ] }, "reaction_10555638": { "compartment": "compartment_7660", "id": "reaction_10555638", "reactome": "R-CEL-5683967", "name": "EYA1-4 dephosphorylates tyrosine Y142 of H2AFX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10555632" ], "products": [ "species_113550", "species_10555554" ], "modifiers": [ [ "species_10555619", "catalyst" ] ], "additional_components": [ "Q9TYU5", "WBGene00007029", "Q23255", "WBGene00003405", "O44199", "WBGene00004296", "P62784", "WBGene00001875", "Q19649", "WBGene00017638", "Q23429", "WBGene00014240", "P62784", "WBGene00001875", "Q19649", "WBGene00017638", "Q23429", "WBGene00014240", "Q9TYU5", "WBGene00007029", "Q23255", "WBGene00003405", "O44199", "WBGene00004296", "WBGene00001377" ] }, "reaction_10556984": { "compartment": "compartment_7660", "id": "reaction_10556984", "reactome": "R-CEL-5693536", "name": "ATM phosphorylates MDC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10556981" ], "products": [ "species_113582", "species_10555565" ], "modifiers": [ [ "species_10556981", "catalyst" ] ], "additional_components": [ "Q9U370", "WBGene00004031", "P62784", "WBGene00001875", "Q19649", "WBGene00017638", "Q23429", "WBGene00014240", "Q9TYU5", "WBGene00007029", "Q23255", "WBGene00003405", "O44199", "WBGene00004296", "P62784", "WBGene00001875", "Q19649", "WBGene00017638", "Q23429", "WBGene00014240", "Q9TYU5", "WBGene00007029", "Q23255", "WBGene00003405", "O44199", "WBGene00004296", "Q9U370", "WBGene00004031", "Q9U370", "WBGene00004031", "P62784", "WBGene00001875", "Q19649", "WBGene00017638", "Q23429", "WBGene00014240", "Q9TYU5", "WBGene00007029", "Q23255", "WBGene00003405", "O44199", "WBGene00004296" ] }, "reaction_10556989": { "compartment": "compartment_7660", "id": "reaction_10556989", "reactome": "R-CEL-5693549", "name": "ATM phosphorylates histone H2AFX on S139 at DNA DSBs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10556986" ], "products": [ "species_113582", "species_10555632" ], "modifiers": [ [ "species_10556986", "catalyst" ] ], "additional_components": [ "P62784", "WBGene00001875", "Q23429", "WBGene00014240", "Q19649", "WBGene00017638", "Q9TYU5", "WBGene00007029", "Q23255", "WBGene00003405", "O44199", "WBGene00004296", "Q9TYU5", "WBGene00007029", "Q23255", "WBGene00003405", "O44199", "WBGene00004296", "P62784", "WBGene00001875", "Q19649", "WBGene00017638", "Q23429", "WBGene00014240", "P62784", "WBGene00001875", "Q23429", "WBGene00014240", "Q19649", "WBGene00017638", "Q9TYU5", "WBGene00007029", "Q23255", "WBGene00003405", "O44199", "WBGene00004296" ] }, "reaction_10555581": { "compartment": "compartment_7660", "id": "reaction_10555581", "reactome": "R-CEL-5683774", "name": "p-T68-CHEK2 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10555577" ], "products": [ "species_10555579" ], "modifiers": [], "additional_components": [ "WBGene00000499", "Q9U1Y5", "WBGene00000499" ] }, "reaction_10555647": { "compartment": "compartment_7660", "id": "reaction_10555647", "reactome": "R-CEL-5683986", "name": "APBB1 and MAPK8 bind diphosphorylated H2AFX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10555643", "species_10510872", "species_10555632" ], "products": [ "species_10555645" ], "modifiers": [], "additional_components": [ "WBGene00001410", "WBGene00002178", "Q9TYU5", "WBGene00007029", "Q23255", "WBGene00003405", "O44199", "WBGene00004296", "P62784", "WBGene00001875", "Q19649", "WBGene00017638", "Q23429", "WBGene00014240", "Q9TYU5", "WBGene00007029", "Q23255", "WBGene00003405", "O44199", "WBGene00004296", "P62784", "WBGene00001875", "Q19649", "WBGene00017638", "Q23429", "WBGene00014240", "Q8WQG9", "WBGene00002178", "Q9BKZ9", "WBGene00001410" ] }, "reaction_10556991": { "compartment": "compartment_7660", "id": "reaction_10556991", "reactome": "R-CEL-5693583", "name": "MDC1 associates with gamma-H2AFX at nuclear foci", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10555554", "species_10556979" ], "products": [ "species_10556981" ], "modifiers": [], "additional_components": [ "P62784", "WBGene00001875", "Q19649", "WBGene00017638", "Q23429", "WBGene00014240", "Q9TYU5", "WBGene00007029", "Q23255", "WBGene00003405", "O44199", "WBGene00004296", "Q9U370", "WBGene00004031", "Q9U370", "WBGene00004031", "P62784", "WBGene00001875", "Q19649", "WBGene00017638", "Q23429", "WBGene00014240", "Q9TYU5", "WBGene00007029", "Q23255", "WBGene00003405", "O44199", "WBGene00004296" ] }, "reaction_10566033": { "compartment": "compartment_70101", "id": "reaction_10566033", "reactome": "R-CEL-8863723", "name": "COP9 and TOR1 deneddylate STON2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10566028" ], "products": [ "species_10566026", "species_10566008", "species_10565943", "species_10556642" ], "modifiers": [ [ "species_10566028", "catalyst" ] ], "additional_components": [ "P90761", "WBGene00006777", "Q95NU5", "WBGene00003870", "Q9N359", "WBGene00000816", "P91001", "WBGene00000817", "Q95PZ0", "WBGene00000818", "Q9GS00", "WBGene00000813", "O01422", "WBGene00000814", "Q9N425", "WBGene00000815", "Q9N359", "WBGene00000816", "P91001", "WBGene00000817", "Q95PZ0", "WBGene00000818", "Q9GS00", "WBGene00000813", "O01422", "WBGene00000814", "Q9N425", "WBGene00000815", "Q95NU5", "WBGene00003870", "WBGene00006777", "WBGene00003587", "P90761", "WBGene00006777", "Q95NU5", "WBGene00003870", "Q9N359", "WBGene00000816", "P91001", "WBGene00000817", "Q95PZ0", "WBGene00000818", "Q9GS00", "WBGene00000813", "O01422", "WBGene00000814", "Q9N425", "WBGene00000815" ] }, "reaction_10566256": { "compartment": "compartment_876", "id": "reaction_10566256", "reactome": "R-CEL-8866277", "name": "AP-2 directly binds some endocytic cargo", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10548814", "species_10566250" ], "products": [ "species_10566252" ], "modifiers": [ [ "species_10566254", "inhibitor" ] ], "additional_components": [ "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q95QV2", "WBGene00000477", "Q19625", "WBGene00003412", "P34711", "WBGene00006756", "Q9XTT3", "WBGene00013039", "Q95QV2", "WBGene00000477", "Q19625", "WBGene00003412", "P34711", "WBGene00006756", "Q9XTT3", "WBGene00013039", "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "P35603", "WBGene00001082", "Q19123", "WBGene00000157" ] }, "reaction_10566272": { "compartment": "compartment_876", "id": "reaction_10566272", "reactome": "R-CEL-8866283", "name": "ARBB recruits GPCRs into clathrin-coated pits", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10566213", "species_10565777" ], "products": [ "species_10566270" ], "modifiers": [ [ "species_10566234", "inhibitor" ] ], "additional_components": [ "Q9N532", "WBGene00003238", "G5EDV1", "WBGene00003006", "P34889", "WBGene00000858", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "Q9U7D5", "WBGene00001519", "P51485", "WBGene00000195", "G5ECQ3", "WBGene00004762", "Q20483", "WBGene00018516", "Q9BIF4", "WBGene00001224", "species_179856", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "Q9TXS0", "WBGene00018974", "Q9N489", "WBGene00022453", "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "Q19123", "WBGene00000157", "P35603", "WBGene00001082", "A0A0K3AS36", "Y116A8C.36d", "G5ECQ3", "WBGene00004762", "Q20483", "WBGene00018516", "Q9BIF4", "WBGene00001224", "species_179856", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "Q9TXS0", "WBGene00018974", "Q9N489", "WBGene00022453", "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "Q19123", "WBGene00000157", "P35603", "WBGene00001082", "A0A0K3AS36", "Y116A8C.36d", "Q9N532", "WBGene00003238", "G5EDV1", "WBGene00003006", "P34889", "WBGene00000858", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "Q9U7D5", "WBGene00001519", "P51485", "WBGene00000195", "Q9BIF4", "WBGene00001224", "Q18453", "WBGene00004682", "Q9BI71", "WBGene00001329", "G5EFF7", "WBGene00008852" ] }, "reaction_10566035": { "compartment": "compartment_70101", "id": "reaction_10566035", "reactome": "R-CEL-8863727", "name": "STON2 is neddylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10565943", "species_10556642" ], "products": [ "species_10565990" ], "modifiers": [], "additional_components": [ "WBGene00006777", "WBGene00003587", "WBGene00006777" ] }, "reaction_10566371": { "compartment": "compartment_876", "id": "reaction_10566371", "reactome": "R-CEL-8867613", "name": "PICALM binds R-SNAREs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10566365", "species_10566363" ], "products": [ "species_10566369" ], "modifiers": [], "additional_components": [ "WBGene00006751", "Q95XH1", "WBGene00022077", "G5EBK2", "WBGene00014084", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q19767", "WBGene00004898", "Q94057", "WBGene00044062", "Q95XH1", "WBGene00022077", "G5EBK2", "WBGene00014084", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q19767", "WBGene00004898", "Q94057", "WBGene00044062", "Q9XZI6", "WBGene00006751" ] }, "reaction_10573106": { "compartment": "compartment_70101", "id": "reaction_10573106", "reactome": "R-CEL-9681616", "name": "AP2 binds chlorpromazine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9648300", "species_10548814" ], "products": [ "species_10566254" ], "modifiers": [], "additional_components": [ "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "P35603", "WBGene00001082", "Q19123", "WBGene00000157" ] }, "reaction_10566215": { "compartment": "compartment_876", "id": "reaction_10566215", "reactome": "R-CEL-8866269", "name": "ARRB bind GPCRs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10521710", "species_10566211" ], "products": [ "species_10566213" ], "modifiers": [], "additional_components": [ "WBGene00000195", "Q9N532", "WBGene00003238", "G5EDV1", "WBGene00003006", "P34889", "WBGene00000858", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "Q9U7D5", "WBGene00001519", "Q9N532", "WBGene00003238", "G5EDV1", "WBGene00003006", "P34889", "WBGene00000858", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "Q9U7D5", "WBGene00001519", "P51485", "WBGene00000195" ] }, "reaction_10565949": { "compartment": "compartment_876", "id": "reaction_10565949", "reactome": "R-CEL-8863463", "name": "STON2 binds SYT proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10565943", "species_10565938" ], "products": [ "species_10565947" ], "modifiers": [], "additional_components": [ "WBGene00006777", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "P90761", "WBGene00006777" ] }, "reaction_10566268": { "compartment": "compartment_876", "id": "reaction_10566268", "reactome": "R-CEL-8866279", "name": "Epsin family proteins bind ubiquitinated cargo", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10566232", "species_10566264" ], "products": [ "species_10566266" ], "modifiers": [], "additional_components": [ "Q9BIF4", "WBGene00001224", "Q18453", "WBGene00004682", "Q9BI71", "WBGene00001329", "Q19019", "WBGene00004829", "Q9BIF4", "WBGene00001224", "P24348", "WBGene00002299", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "B1V8A0", "WBGene00006791", "P29355", "WBGene00004774", "Q17796", "WBGene00004101", "O01498", "WBGene00004109", "Q18453", "WBGene00004682", "Q9BI71", "WBGene00001329", "Q9BIF4", "WBGene00001224", "Q18453", "WBGene00004682", "Q9BI71", "WBGene00001329", "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "B1V8A0", "WBGene00006791", "P29355", "WBGene00004774", "Q17796", "WBGene00004101", "O01498", "WBGene00004109" ] }, "reaction_10566236": { "compartment": "compartment_70101", "id": "reaction_10566236", "reactome": "R-CEL-8866275", "name": "UBQLNs bind UIM-containing adaptor proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10566220", "species_10566232" ], "products": [ "species_10566234" ], "modifiers": [], "additional_components": [ "WBGene00008852", "Q9BIF4", "WBGene00001224", "Q18453", "WBGene00004682", "Q9BI71", "WBGene00001329", "Q9BIF4", "WBGene00001224", "Q18453", "WBGene00004682", "Q9BI71", "WBGene00001329", "G5EFF7", "WBGene00008852" ] }, "reaction_10565967": { "compartment": "compartment_876", "id": "reaction_10565967", "reactome": "R-CEL-8863472", "name": "DAB2 binds LRP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10565951", "species_10565963" ], "products": [ "species_10565965" ], "modifiers": [], "additional_components": [ "WBGene00000894", "Q21496", "WBGene00020010", "Q21948", "WBGene00020010", "Q21496", "WBGene00020010", "Q21948", "WBGene00020010", "A0A486WXX8", "WBGene00000894" ] }, "reaction_10566030": { "compartment": "compartment_70101", "id": "reaction_10566030", "reactome": "R-CEL-8863721", "name": "NEDD8-STON binds TOR1 hexamer and COP9 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10566026", "species_10566008", "species_10565990" ], "products": [ "species_10566028" ], "modifiers": [], "additional_components": [ "Q9N359", "WBGene00000816", "P91001", "WBGene00000817", "Q95PZ0", "WBGene00000818", "Q9GS00", "WBGene00000813", "O01422", "WBGene00000814", "Q9N425", "WBGene00000815", "Q95NU5", "WBGene00003870", "WBGene00006777", "P90761", "WBGene00006777", "Q95NU5", "WBGene00003870", "Q9N359", "WBGene00000816", "P91001", "WBGene00000817", "Q95PZ0", "WBGene00000818", "Q9GS00", "WBGene00000813", "O01422", "WBGene00000814", "Q9N425", "WBGene00000815" ] }, "reaction_10506050": { "compartment": "compartment_70101", "id": "reaction_10506050", "reactome": "R-CEL-73571", "name": "CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111628", "species_70106" ], "products": [ "species_29356", "species_76630" ], "modifiers": [ [ "species_10506047", "catalyst" ] ], "additional_components": [ "Q18990", "WBGene00004259" ] }, "reaction_10506053": { "compartment": "compartment_70101", "id": "reaction_10506053", "reactome": "R-CEL-73573", "name": "CAD hexamer transforms CAP to N-carb-L-Asp", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111647", "species_29448" ], "products": [ "species_111628", "species_29372" ], "modifiers": [ [ "species_10506047", "catalyst" ] ], "additional_components": [ "Q18990", "WBGene00004259" ] }, "reaction_10506056": { "compartment": "compartment_70101", "id": "reaction_10506056", "reactome": "R-CEL-73577", "name": "CAD hexamer transforms L-Gln to CAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_111627", "species_113592", "species_29472" ], "products": [ "species_111647", "species_29372", "species_29404", "species_29370" ], "modifiers": [ [ "species_10506047", "catalyst" ] ], "additional_components": [ "Q18990", "WBGene00004259" ] }, "reaction_10506040": { "compartment": "compartment_70101", "id": "reaction_10506040", "reactome": "R-CEL-73569", "name": "DHODH:FMN oxidises (S)-DHO to orotate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73663", "species_76630" ], "products": [ "species_76632", "species_76633" ], "modifiers": [ [ "species_10506037", "catalyst" ] ], "additional_components": [ "O01815", "WBGene00020932", "species_73524" ] }, "reaction_10506027": { "compartment": "compartment_70101", "id": "reaction_10506027", "reactome": "R-CEL-73564", "name": "UMPS dimer decarboxylates OMP to UMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111629" ], "products": [ "species_109402", "species_113528" ], "modifiers": [ [ "species_10506024", "catalyst" ] ], "additional_components": [ "G5EDZ2", "WBGene00011559" ] }, "reaction_10506030": { "compartment": "compartment_70101", "id": "reaction_10506030", "reactome": "R-CEL-73567", "name": "UMPS dimer transfers phoshoribosyl group to ORO to form OMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73566", "species_76632" ], "products": [ "species_111294", "species_111629" ], "modifiers": [ [ "species_10506024", "catalyst" ] ], "additional_components": [ "G5EDZ2", "WBGene00011559" ] }, "reaction_10508834": { "compartment": "compartment_70101", "id": "reaction_10508834", "reactome": "R-CEL-111285", "name": "Formation of phosphoribosyl pyrophosphate amidotransferase tetramer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10506404" ], "products": [ "species_10508832" ], "modifiers": [ [ "species_113578", "catalyst" ], [ "species_29602", "catalyst" ], [ "species_76577", "catalyst" ] ], "additional_components": [ "Q22134", "WBGene00011407", "CHEBI:17909", "species_113531", "Q22134", "WBGene00011407", "CHEBI:17909", "species_113531" ] }, "reaction_10508866": { "compartment": "compartment_70101", "id": "reaction_10508866", "reactome": "R-CEL-111524", "name": "IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_29448", "species_29602" ], "products": [ "species_29372", "species_29420", "species_35141" ], "modifiers": [ [ "species_10508863", "catalyst" ], [ "species_29420", "inhibitor" ], [ "species_30014", "inhibitor" ], [ "species_113578", "inhibitor" ], [ "species_35141", "inhibitor" ] ], "additional_components": [ "P91134", "WBGene00016509", "species_114632" ] }, "reaction_10508836": { "compartment": "compartment_70101", "id": "reaction_10508836", "reactome": "R-CEL-111289", "name": "Dissociation of phosphoribosyl pyrophosphate amidotransferase tetramer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508832" ], "products": [ "species_10506404" ], "modifiers": [ [ "species_73566", "catalyst" ] ], "additional_components": [ "Q22134", "WBGene00011407", "CHEBI:17909", "species_113531", "Q22134", "WBGene00011407", "CHEBI:17909", "species_113531" ] }, "reaction_10506340": { "compartment": "compartment_70101", "id": "reaction_10506340", "reactome": "R-CEL-73792", "name": "XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_111584", "species_29472" ], "products": [ "species_111294", "species_29404", "species_113578", "species_76577" ], "modifiers": [ [ "species_10506337", "catalyst" ] ], "additional_components": [ "WBGene00010912" ] }, "reaction_10506407": { "compartment": "compartment_70101", "id": "reaction_10506407", "reactome": "R-CEL-73815", "name": "5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73566", "species_29356", "species_29472" ], "products": [ "species_111294", "species_111292", "species_29404" ], "modifiers": [ [ "species_10506404", "catalyst" ] ], "additional_components": [ "Q22134", "WBGene00011407", "CHEBI:17909", "species_113531" ] }, "reaction_10506376": { "compartment": "compartment_70101", "id": "reaction_10506376", "reactome": "R-CEL-73800", "name": "SAICAR => AICAR + Fumarate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111399" ], "products": [ "species_29586", "species_111409" ], "modifiers": [ [ "species_10506373", "catalyst" ] ], "additional_components": [ "Q21774", "WBGene00011064" ] }, "reaction_10506409": { "compartment": "compartment_70101", "id": "reaction_10506409", "reactome": "R-CEL-73828", "name": "adenylosuccinate => adenosine 5'-monophosphate + fumarate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_35141" ], "products": [ "species_29586", "species_76577" ], "modifiers": [ [ "species_10506373", "catalyst" ] ], "additional_components": [ "Q21774", "WBGene00011064" ] }, "reaction_10506352": { "compartment": "compartment_70101", "id": "reaction_10506352", "reactome": "R-CEL-73794", "name": "IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_29602", "species_29360" ], "products": [ "species_70106", "species_111584", "species_73473" ], "modifiers": [ [ "species_10506347", "catalyst" ], [ "species_111584", "inhibitor" ], [ "species_10506350", "inhibitor" ] ], "additional_components": [ "Q9GZH3", "WBGene00020682", "Q9GZH3", "WBGene00020682" ] }, "reaction_10506386": { "compartment": "compartment_70101", "id": "reaction_10506386", "reactome": "R-CEL-73805", "name": "CAIR + Aspartate + ATP => SAICAR + ADP + Pi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_29448", "species_111395" ], "products": [ "species_29372", "species_29370", "species_111399" ], "modifiers": [ [ "species_10506383", "catalyst" ] ], "additional_components": [ "Q10457", "WBGene00015116" ] }, "reaction_10506389": { "compartment": "compartment_70101", "id": "reaction_10506389", "reactome": "R-CEL-73806", "name": "AIR + CO2 => CAIR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111370", "species_113528" ], "products": [ "species_111395" ], "modifiers": [ [ "species_10506383", "catalyst" ] ], "additional_components": [ "Q10457", "WBGene00015116" ] }, "reaction_10506363": { "compartment": "compartment_70101", "id": "reaction_10506363", "reactome": "R-CEL-73797", "name": "FAICAR => IMP + H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111427" ], "products": [ "species_29356", "species_29602" ], "modifiers": [ [ "species_10506360", "catalyst" ] ], "additional_components": [ "Q95QQ4", "WBGene00016957" ] }, "reaction_10558365": { "compartment": "compartment_70101", "id": "reaction_10558365", "reactome": "R-CEL-6788912", "name": "LHPP:Mg2+ dimer hydrolyses PPi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111294", "species_29356" ], "products": [ "species_29372" ], "modifiers": [ [ "species_10558362", "catalyst" ] ], "additional_components": [ "species_114632", "O01926", "WBGene00007548" ] }, "reaction_10506397": { "compartment": "compartment_70101", "id": "reaction_10506397", "reactome": "R-CEL-73812", "name": "FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_111354", "species_113592", "species_29472" ], "products": [ "species_29372", "species_29404", "species_29370", "species_111369" ], "modifiers": [ [ "species_10506394", "catalyst" ] ], "additional_components": [ "WBGene00008654" ] }, "reaction_10573084": { "compartment": "compartment_70101", "id": "reaction_10573084", "reactome": "R-CEL-9678749", "name": "IMPDH tetramers binds IMPDH inhibitors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9678719", "species_10506347" ], "products": [ "species_10506350" ], "modifiers": [], "additional_components": [ "Q9GZH3", "WBGene00020682", "Q9GZH3", "WBGene00020682" ] }, "reaction_10506366": { "compartment": "compartment_70101", "id": "reaction_10506366", "reactome": "R-CEL-73798", "name": "AICAR + 10-Formyl-THF => FAICAR + THF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_419151", "species_111409" ], "products": [ "species_111355", "species_111427" ], "modifiers": [ [ "species_10506360", "catalyst" ] ], "additional_components": [ "Q95QQ4", "WBGene00016957" ] }, "reaction_10573092": { "compartment": "compartment_876", "id": "reaction_10573092", "reactome": "R-CEL-9679740", "name": "ITGA4:ITGB1 binds natalizumab", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10514207", "species_9679737" ], "products": [ "species_10573090" ], "modifiers": [], "additional_components": [ "Q27874", "WBGene00003930", "P34446", "WBGene00003929", "Q27874", "WBGene00003930", "P34446", "WBGene00003929" ] }, "reaction_10515321": { "compartment": "compartment_876", "id": "reaction_10515321", "reactome": "R-CEL-202723", "name": "Integrin alpha5beta1 binds FN1 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_266099", "species_10515317", "species_10515313" ], "products": [ "species_10515319" ], "modifiers": [], "additional_components": [ "P34446", "WBGene00003929", "Q27874", "WBGene00003930", "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769", "P34446", "WBGene00003929", "Q27874", "WBGene00003930", "species_266099" ] }, "reaction_10515290": { "compartment": "compartment_876", "id": "reaction_10515290", "reactome": "R-CEL-202710", "name": "MERTK receptor binds ligands (Gas6 or Protein S)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10515286", "species_10515280" ], "products": [ "species_10515288" ], "modifiers": [], "additional_components": [ "G5EFX3", "WBGene00013416", "Q9XWD6", "WBGene00000415", "WBGene00008711", "Q9XVQ7", "WBGene00008711", "G5EFX3", "WBGene00013416", "Q9XWD6", "WBGene00000415" ] }, "reaction_10545950": { "compartment": "compartment_876", "id": "reaction_10545950", "reactome": "R-CEL-2870221", "name": "E-selectin binds E-selectin ligand", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10545946", "species_10545941" ], "products": [ "species_10545948" ], "modifiers": [], "additional_components": [ "WBGene00008800", "Q18849", "WBGene00009500", "Q22328", "WBGene00002976", "A0A1N7SYP5", "WBGene00009500", "Q18849", "WBGene00009500", "Q22328", "WBGene00002976", "A0A1N7SYP5", "WBGene00009500", "Q19459", "WBGene00008800" ] }, "reaction_10572733": { "compartment": "compartment_17957", "id": "reaction_10572733", "reactome": "R-CEL-9650473", "name": "SERPING1 is secreted", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10572731" ], "products": [ "species_10526610" ], "modifiers": [], "additional_components": [ "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "A9Z1L1", "WBGene00005648", "G5ECY2", "WBGene00005644", "Q19651", "WBGene00005649", "A9Z1L1", "WBGene00005648", "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q18287", "WBGene00016187" ] }, "reaction_10509775": { "compartment": "compartment_984", "id": "reaction_10509775", "reactome": "R-CEL-140806", "name": "SERPINC1 binds SERPINC1 activators", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509755", "species_9693058" ], "products": [ "species_10509773" ], "modifiers": [], "additional_components": [ "G5ECY2", "WBGene00005644", "Q18287", "WBGene00016187", "G5EE40", "WBGene00005642", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647", "A9Z1L1", "WBGene00005648", "O17365", "WBGene00005643", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "A9Z1L1", "WBGene00005648", "G5ECY2", "WBGene00005644" ] }, "reaction_10566692": { "compartment": "compartment_12045", "id": "reaction_10566692", "reactome": "R-CEL-8869206", "name": "PAFAH2 hydrolyses PAF to lyso-PAF and acetate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_8869214" ], "products": [ "species_29416", "species_8869207" ], "modifiers": [ [ "species_10566689", "catalyst" ] ], "additional_components": [ "G5EGT1", "WBGene00003906", "Q22943", "WBGene00003907" ] }, "reaction_10523812": { "compartment": "compartment_70101", "id": "reaction_10523812", "reactome": "R-CEL-432148", "name": "Fgr may phosphorylate p38 MAPK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10523344" ], "products": [ "species_10512654", "species_29370" ], "modifiers": [ [ "species_10523809", "catalyst" ] ], "additional_components": [ "WBGene00004055", "WBGene00004055", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635" ] }, "reaction_10509648": { "compartment": "compartment_70101", "id": "reaction_10509648", "reactome": "R-CEL-114683", "name": "Phosphorylation of Platelet Sec-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10509637" ], "products": [ "species_10509645", "species_29370" ], "modifiers": [ [ "species_10509553", "catalyst" ] ], "additional_components": [ "P34815", "WBGene00006757", "O44412", "WBGene00020298", "O44412", "WBGene00020298", "P34815", "WBGene00006757", "species_114519", "P90980", "WBGene00004033", "species_33625", "species_74016" ] }, "reaction_10509555": { "compartment": "compartment_70101", "id": "reaction_10509555", "reactome": "R-CEL-114553", "name": "Activation of conventional Protein Kinase C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_33625", "species_114519", "species_10509044", "species_74016" ], "products": [ "species_10509553" ], "modifiers": [ [ "species_114519", "catalyst" ] ], "additional_components": [ "WBGene00004033", "species_114519", "P90980", "WBGene00004033", "species_33625", "species_74016" ] }, "reaction_10526786": { "compartment": "compartment_876", "id": "reaction_10526786", "reactome": "R-CEL-481010", "name": "Surface deployment of platelet dense granule membrane components", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10526770" ], "products": [ "species_10526784" ], "modifiers": [], "additional_components": [ "G5EBS5", "WBGene00000089", "Q9GYK0", "WBGene00015471", "Q11117", "WBGene00003053", "Q17441", "WBGene00006646", "Q22328", "WBGene00002976", "Q11117", "WBGene00003053", "Q9GYK0", "WBGene00015471", "Q17441", "WBGene00006646", "Q22328", "WBGene00002976", "G5EBS5", "WBGene00000089" ] }, "reaction_10526658": { "compartment": "compartment_876", "id": "reaction_10526658", "reactome": "R-CEL-481007", "name": "Exocytosis of platelet alpha granule contents", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10526516" ], "products": [ "species_10526656" ], "modifiers": [], "additional_components": [ "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769", "A9Z1L1", "WBGene00005648", "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "Q09387", "WBGene00019944", "Q9N413", "WBGene00004249", "K8F7Z5", "WBGene00008735", "Q7YTU0", "WBGene00013969", "G5EFX3", "WBGene00013416", "Q9XWD6", "WBGene00000415", "P34714", "WBGene00003893", "H2KZY5", "WBGene00018533", "G5EEL5", "WBGene00000936", "G5EBY8", "WBGene00006852", "Q21154", "WBGene00019333", "Q18685", "WBGene00006836", "Q10651", "WBGene00000149", "Q18245", "WBGene00007764", "Q23580", "WBGene00022789", "Q9GZE9", "WBGene00017719", "Q9XXG5", "WBGene00006598", "O45271", "WBGene00006597", "Q95NU5", "WBGene00003870", "Q23158", "WBGene00000228", "Q22174", "WBGene00011449", "P91917", "WBGene00012344", "P46563", "WBGene00017166", "P54216", "WBGene00011474", "Q9XWD6", "WBGene00000415", "G5EFX3", "WBGene00013416", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "A9Z1L1", "WBGene00005648", "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "H2KZY5", "WBGene00018533", "K8F7Z5", "WBGene00008735", "Q7YTU0", "WBGene00013969", "Q21154", "WBGene00019333", "Q22174", "WBGene00011449", "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769", "Q9N413", "WBGene00004249", "P91917", "WBGene00012344", "Q23158", "WBGene00000228", "Q09387", "WBGene00019944", "G5EEL5", "WBGene00000936", "G5EBY8", "WBGene00006852", "P34714", "WBGene00003893", "Q10651", "WBGene00000149", "Q18245", "WBGene00007764", "Q23580", "WBGene00022789", "O45271", "WBGene00006597", "Q95NU5", "WBGene00003870", "Q9XXG5", "WBGene00006598", "P46563", "WBGene00017166", "P54216", "WBGene00011474", "Q18685", "WBGene00006836", "Q9GZE9", "WBGene00017719" ] }, "reaction_10523396": { "compartment": "compartment_114584", "id": "reaction_10523396", "reactome": "R-CEL-429157", "name": "ABCC4 accumulation of dense granule contents", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29370" ], "products": [ "species_114565" ], "modifiers": [ [ "species_10523393", "catalyst" ] ], "additional_components": [ "WBGene00003412" ] }, "reaction_10526744": { "compartment": "compartment_876", "id": "reaction_10526744", "reactome": "R-CEL-481009", "name": "Exocytosis of platelet dense granule content", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10526706" ], "products": [ "species_10526742" ], "modifiers": [], "additional_components": [ "species_29438", "species_113582", "species_114632", "O02108", "WBGene00021097", "H2L0F2", "WBGene00019497", "species_29358", "O16454", "WBGene00007055", "Q688B0", "WBGene00019786", "species_29372", "Q19651", "WBGene00005649", "A9Z1L1", "WBGene00005648", "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "species_74016", "A0A1N7SYP5", "WBGene00009500", "Q18849", "WBGene00009500", "Q22328", "WBGene00002976", "species_380585", "species_29420", "species_113541", "species_74016", "Q19651", "WBGene00005649", "A9Z1L1", "WBGene00005648", "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "species_29438", "species_113582", "species_113541", "species_114632", "A0A1N7SYP5", "WBGene00009500", "Q18849", "WBGene00009500", "Q22328", "WBGene00002976", "species_29358", "H2L0F2", "WBGene00019497", "O02108", "WBGene00021097", "O16454", "WBGene00007055", "Q688B0", "WBGene00019786", "species_380585", "species_29372", "species_29420" ] }, "reaction_10526856": { "compartment": "compartment_876", "id": "reaction_10526856", "reactome": "R-CEL-481044", "name": "Surface deployment of platelet alpha granule membrane components", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10526830" ], "products": [ "species_10526854" ], "modifiers": [], "additional_components": [ "Q9N4L6", "WBGene00022836", "Q9XVI4", "WBGene00006633", "P34616", "WBGene00000395", "U4PMB9", "WBGene00021362", "Q22328", "WBGene00002976", "O16521", "WBGene00020268", "O16522", "WBGene00020267", "Q10651", "WBGene00000149", "P91855", "WBGene00009174", "Q7YTU0", "WBGene00013969", "Q9XVI4", "WBGene00006633", "Q10651", "WBGene00000149", "O16522", "WBGene00020267", "O16521", "WBGene00020268", "Q7YTU0", "WBGene00013969", "P34616", "WBGene00000395", "U4PMB9", "WBGene00021362", "P91855", "WBGene00009174", "Q22328", "WBGene00002976", "Q9N4L6", "WBGene00022836" ] }, "reaction_10518043": { "compartment": "compartment_161320", "id": "reaction_10518043", "reactome": "R-CEL-351341", "name": "Exocytosis of Proactivator polypeptide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10518035" ], "products": [ "species_10518041" ], "modifiers": [], "additional_components": [ "Q18607", "WBGene00016642", "Q18276", "WBGene00004995", "Q18607", "WBGene00016642", "Q18276", "WBGene00004995" ] }, "reaction_10527071": { "compartment": "compartment_70101", "id": "reaction_10527071", "reactome": "R-CEL-482772", "name": "Release of platelet cytosolic components", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10526977" ], "products": [ "species_10527069" ], "modifiers": [], "additional_components": [ "P19826", "WBGene00000942", "H2KYR1", "WBGene00006924", "O44412", "WBGene00020298", "P34815", "WBGene00006757", "P52274", "WBGene00006534", "H2L2E8", "WBGene00006528", "P91910", "WBGene00003175", "O18154", "WBGene00006533", "P34690", "WBGene00006529", "G5EDD4", "WBGene00006530", "O17939", "WBGene00010685", "P0DM41", "WBGene00000063", "P0DM42", "WBGene00000065", "P10984", "WBGene00000064", "P10986", "WBGene00000066", "G5EGK1", "WBGene00006771", "P34697", "WBGene00004930", "Q27538", "WBGene00007036", "Q09936", "WBGene00016898", "Q23050", "WBGene00020808", "G5EFB5", "WBGene00000777", "O44788", "WBGene00000778", "D0VWL6", "WBGene00016006", "U4PBJ9", "WBGene00022048", "Q11083", "WBGene00020378", "P04630", "WBGene00000285", "G5EF37", "WBGene00003934", "A0A2C9C3L3", "WBGene00020378", "Q18136", "WBGene00006861", "Q09665", "WBGene00006583", "O02159", "WBGene00020378", "G5EDZ8", "WBGene00000288", "Q94288", "WBGene00000287", "Q09980", "WBGene00017394", "O16305", "WBGene00000552", "G5EEG0", "WBGene00000286", "Q20318", "WBGene00003034", "Q9N3B0", "WBGene00021888", "H2KYR1", "WBGene00006924", "D0VWL6", "WBGene00016006", "U4PBJ9", "WBGene00022048", "A0A2C9C3L3", "WBGene00020378", "Q09980", "WBGene00017394", "G5EDZ8", "WBGene00000288", "Q11083", "WBGene00020378", "G5EEG0", "WBGene00000286", "Q18136", "WBGene00006861", "G5EF37", "WBGene00003934", "Q94288", "WBGene00000287", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "P04630", "WBGene00000285", "Q09665", "WBGene00006583", "G5EGK1", "WBGene00006771", "P19826", "WBGene00000942", "O17939", "WBGene00010685", "G5EDD4", "WBGene00006530", "H2L2E8", "WBGene00006528", "O18154", "WBGene00006533", "P34690", "WBGene00006529", "P52274", "WBGene00006534", "P91910", "WBGene00003175", "O44412", "WBGene00020298", "P34815", "WBGene00006757", "Q27538", "WBGene00007036", "P34697", "WBGene00004930", "Q20318", "WBGene00003034", "G5EFB5", "WBGene00000777", "O44788", "WBGene00000778", "Q09936", "WBGene00016898", "Q23050", "WBGene00020808", "Q9N3B0", "WBGene00021888", "P0DM41", "WBGene00000063", "P0DM42", "WBGene00000065", "P10984", "WBGene00000064", "P10986", "WBGene00000066" ] }, "reaction_10509664": { "compartment": "compartment_70101", "id": "reaction_10509664", "reactome": "R-CEL-114689", "name": "PLC gamma 2-mediated PIP2 hydrolysis", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179856" ], "products": [ "species_114520", "species_114519" ], "modifiers": [ [ "species_10509661", "catalyst" ] ], "additional_components": [ "WBGene00004038" ] }, "reaction_10524321": { "compartment": "compartment_70101", "id": "reaction_10524321", "reactome": "R-CEL-442314", "name": "VAV3 is a GEF for Rho/Rac family kinases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10524313" ], "products": [ "species_29420", "species_10524315" ], "modifiers": [ [ "species_10524318", "catalyst" ] ], "additional_components": [ "Q22038", "WBGene00004357", "Q03206", "ced-10", "species_29420", "Q22038", "WBGene00004357", "Q03206", "ced-10", "species_29438", "WBGene00006887" ] }, "reaction_10523412": { "compartment": "compartment_876", "id": "reaction_10523412", "reactome": "R-CEL-429497", "name": "SLP-76 stimulates PLC gamma 2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10523410" ], "products": [ "species_10509661" ], "modifiers": [], "additional_components": [ "WBGene00004038", "WBGene00004038" ] }, "reaction_10524309": { "compartment": "compartment_70101", "id": "reaction_10524309", "reactome": "R-CEL-442291", "name": "VAV2 is a GEF for Rho/Rac family kinases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10524301" ], "products": [ "species_10524303", "species_29420" ], "modifiers": [ [ "species_10524306", "catalyst" ] ], "additional_components": [ "Q22038", "WBGene00004357", "species_29420", "Q22038", "WBGene00004357", "species_29438", "WBGene00006887" ] }, "reaction_10524295": { "compartment": "compartment_70101", "id": "reaction_10524295", "reactome": "R-CEL-442273", "name": "VAV1 is a GEF for Rho/Rac family GTPases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10524283" ], "products": [ "species_10524285", "species_29420" ], "modifiers": [ [ "species_10524288", "catalyst" ], [ "species_10524293", "catalyst" ], [ "species_10524291", "inhibitor" ] ], "additional_components": [ "Q94124", "WBGene00004287", "Q9BL44", "WBGene00022177", "Q03206", "ced-10", "species_29420", "Q94124", "WBGene00004287", "Q9BL44", "WBGene00022177", "Q03206", "ced-10", "species_29438", "WBGene00006887", "Q45FX5", "WBGene00006887", "species_179838", "species_179856", "Q45FX5", "WBGene00006887" ] }, "reaction_10524234": { "compartment": "compartment_70101", "id": "reaction_10524234", "reactome": "R-CEL-437162", "name": "PI3K alpha, beta, gamma convert PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10506892", "catalyst" ] ], "additional_components": [ "G5EDP9", "WBGene00000001", "Q94125", "WBGene00000090" ] }, "reaction_10521714": { "compartment": "compartment_70101", "id": "reaction_10521714", "reactome": "R-CEL-418091", "name": "F2R binds ARRB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10521710", "species_10521705" ], "products": [ "species_10521712" ], "modifiers": [], "additional_components": [ "WBGene00000195", "WBGene00016570", "H2KZ99", "WBGene00016570", "P51485", "WBGene00000195" ] }, "reaction_10509539": { "compartment": "compartment_70101", "id": "reaction_10509539", "reactome": "R-CEL-114552", "name": "Thrombin-activated PARs activate G12/13", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10509526" ], "products": [ "species_29420", "species_10509536" ], "modifiers": [ [ "species_10509512", "catalyst" ] ], "additional_components": [ "species_29420", "Q19572", "WBGene00001674", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "H2KZ99", "WBGene00016570", "H2KZ99", "WBGene00016570", "Q19572", "WBGene00001674", "species_29438", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "WBGene00016570" ] }, "reaction_10521731": { "compartment": "compartment_70101", "id": "reaction_10521731", "reactome": "R-CEL-418172", "name": "F2R binds ARRB2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10521727", "species_10521705" ], "products": [ "species_10521729" ], "modifiers": [], "additional_components": [ "WBGene00000195", "WBGene00016570", "H2KZ99", "WBGene00016570", "P51485", "WBGene00000195" ] }, "reaction_10521092": { "compartment": "compartment_876", "id": "reaction_10521092", "reactome": "R-CEL-396996", "name": "Thrombin-activated PARs binds G-protein Gq", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509512", "species_10509559" ], "products": [ "species_10509561" ], "modifiers": [], "additional_components": [ "WBGene00016570", "species_29420", "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "species_29420", "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "H2KZ99", "WBGene00016570" ] }, "reaction_10521094": { "compartment": "compartment_876", "id": "reaction_10521094", "reactome": "R-CEL-397835", "name": "Thrombin-activated PARs:Gq (active) dissociate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509563" ], "products": [ "species_10509165", "species_10508937", "species_10509512" ], "modifiers": [], "additional_components": [ "H2KZ99", "WBGene00016570", "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196", "species_29438", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196", "species_29438", "WBGene00016570" ] }, "reaction_10521718": { "compartment": "compartment_70101", "id": "reaction_10521718", "reactome": "R-CEL-418158", "name": "SRC-1 is activated (in F2R:ARRB1:MAPKs:SRC-1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10521716" ], "products": [ "species_10521716" ], "modifiers": [], "additional_components": [ "H2KZ99", "WBGene00016570", "P51485", "WBGene00000195", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "P39745", "WBGene00003401", "H2KZ99", "WBGene00016570", "P51485", "WBGene00000195", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "P39745", "WBGene00003401" ] }, "reaction_10521735": { "compartment": "compartment_70101", "id": "reaction_10521735", "reactome": "R-CEL-418176", "name": "F2R:ARRB2 binds MAPKs, SRC-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508575", "species_10513079", "species_10521729" ], "products": [ "species_10521733" ], "modifiers": [], "additional_components": [ "WBGene00003401", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "H2KZ99", "WBGene00016570", "P51485", "WBGene00000195", "H2KZ99", "WBGene00016570", "P51485", "WBGene00000195", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "P39745", "WBGene00003401" ] }, "reaction_10521737": { "compartment": "compartment_70101", "id": "reaction_10521737", "reactome": "R-CEL-418200", "name": "SRC-1 bound to ARRB2 is not activated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10521733" ], "products": [ "species_10521733" ], "modifiers": [], "additional_components": [ "H2KZ99", "WBGene00016570", "P51485", "WBGene00000195", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "P39745", "WBGene00003401", "H2KZ99", "WBGene00016570", "P51485", "WBGene00000195", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "P39745", "WBGene00003401" ] }, "reaction_10521098": { "compartment": "compartment_876", "id": "reaction_10521098", "reactome": "R-CEL-397891", "name": "Thrombin-activated PARs:G12/13 (active) dissociate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509536" ], "products": [ "species_10509165", "species_10509512", "species_10521096" ], "modifiers": [], "additional_components": [ "H2KZ99", "WBGene00016570", "Q19572", "WBGene00001674", "species_29438", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "WBGene00016570", "Q19572", "WBGene00001674", "species_29438" ] }, "reaction_10521723": { "compartment": "compartment_70101", "id": "reaction_10521723", "reactome": "R-CEL-418163", "name": "Activated SRC-1 activates MAPKs (in F2R:ARRB1:MAPKs:active SRC-1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10521716" ], "products": [ "species_10521720" ], "modifiers": [ [ "species_10521716", "catalyst" ] ], "additional_components": [ "H2KZ99", "WBGene00016570", "P51485", "WBGene00000195", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "P39745", "WBGene00003401", "H2KZ99", "WBGene00016570", "P51485", "WBGene00000195", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "P39745", "WBGene00003401", "H2KZ99", "WBGene00016570", "P51485", "WBGene00000195", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "P39745", "WBGene00003401" ] }, "reaction_10509565": { "compartment": "compartment_70101", "id": "reaction_10509565", "reactome": "R-CEL-114558", "name": "Thrombin-activated PARs activate Gq", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10509561" ], "products": [ "species_29420", "species_10509563" ], "modifiers": [ [ "species_10509512", "catalyst" ] ], "additional_components": [ "species_29420", "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "H2KZ99", "WBGene00016570", "H2KZ99", "WBGene00016570", "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196", "species_29438", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "WBGene00016570" ] }, "reaction_10521725": { "compartment": "compartment_70101", "id": "reaction_10521725", "reactome": "R-CEL-418170", "name": "F2R:ARRB1 binds MAPKs, SRC-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508575", "species_10513079", "species_10521712" ], "products": [ "species_10521716" ], "modifiers": [], "additional_components": [ "WBGene00003401", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "H2KZ99", "WBGene00016570", "P51485", "WBGene00000195", "H2KZ99", "WBGene00016570", "P51485", "WBGene00000195", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "P39745", "WBGene00003401" ] }, "reaction_10528130": { "compartment": "compartment_70101", "id": "reaction_10528130", "reactome": "R-CEL-879459", "name": "F-actin capping protein is a heterodimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10528126", "species_10528121" ], "products": [ "species_10528128" ], "modifiers": [], "additional_components": [ "WBGene00000293", "WBGene00000292", "P34685", "WBGene00000292", "P34686", "WBGene00000293" ] }, "reaction_10531587": { "compartment": "compartment_70101", "id": "reaction_10531587", "reactome": "R-CEL-984606", "name": "Kinesin-5 is a homotetramer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10531494" ], "products": [ "species_10531496" ], "modifiers": [], "additional_components": [ "WBGene00000257", "G5ECF4", "WBGene00000257" ] }, "reaction_10531589": { "compartment": "compartment_70101", "id": "reaction_10531589", "reactome": "R-CEL-984648", "name": "Kinesin-6 and RACGAP1 form the heterotetrameric complex centralspindlin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10531503", "species_10531498" ], "products": [ "species_10531505" ], "modifiers": [], "additional_components": [ "WBGene00000875", "WBGene00006974", "Q8MQ03", "WBGene00006974", "Q9XUS9", "WBGene00000875" ] }, "reaction_10531464": { "compartment": "compartment_70101", "id": "reaction_10531464", "reactome": "R-CEL-983194", "name": "Kinesin-1 is a heterotetramer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10531453", "species_10531458" ], "products": [ "species_10531462" ], "modifiers": [], "additional_components": [ "P46822", "WBGene00002215", "H9G2T2", "WBGene00002214", "WBGene00006840", "P34540", "WBGene00006840", "P46822", "WBGene00002215", "H9G2T2", "WBGene00002214" ] }, "reaction_10531593": { "compartment": "compartment_70101", "id": "reaction_10531593", "reactome": "R-CEL-984733", "name": "Kinesin-3 is a dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10531591" ], "products": [ "species_10531489" ], "modifiers": [], "additional_components": [ "Q965T6", "WBGene00002230", "Q965T6", "WBGene00002230" ] }, "reaction_10531595": { "compartment": "compartment_70101", "id": "reaction_10531595", "reactome": "R-CEL-990489", "name": "Kinesin-13 is a dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10531521" ], "products": [ "species_10531529" ], "modifiers": [], "additional_components": [ "WBGene00002219", "Q9XU12", "WBGene00002219" ] }, "reaction_10531636": { "compartment": "compartment_7660", "id": "reaction_10531636", "reactome": "R-CEL-994106", "name": "HP1 alpha binds Histone H3K9(me)3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10531624", "species_10531632" ], "products": [ "species_10531634" ], "modifiers": [], "additional_components": [ "WBGene00000414", "K7ZUH9", "WBGene00001914", "Q10453", "WBGene00001945", "K7ZUH9", "WBGene00001914", "Q10453", "WBGene00001945", "P34618", "WBGene00000414" ] }, "reaction_10566148": { "compartment": "compartment_70101", "id": "reaction_10566148", "reactome": "R-CEL-8865107", "name": "MICAL1 produces NADP+, H2O2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_29364" ], "products": [ "species_29366", "species_29408" ], "modifiers": [ [ "species_10566145", "catalyst" ] ], "additional_components": [ "species_113596", "A0A061AD47", "WBGene00013289" ] }, "reaction_10531622": { "compartment": "compartment_70101", "id": "reaction_10531622", "reactome": "R-CEL-992708", "name": "Dual-specific AKAPs bind type I and II PKA regulatory subunits", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508956", "species_10531618" ], "products": [ "species_10531620" ], "modifiers": [], "additional_components": [ "P30625", "WBGene00002190", "P21137", "WBGene00002189", "Q10955", "WBGene00004348", "Q09285", "WBGene00016977", "Q10955", "WBGene00004348", "Q09285", "WBGene00016977", "P30625", "WBGene00002190", "P21137", "WBGene00002189" ] }, "reaction_10531606": { "compartment": "compartment_17906", "id": "reaction_10531606", "reactome": "R-CEL-992703", "name": "Mitofusins trans-interact linking mitochondria prior to fusion", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10531600" ], "products": [ "species_10531604" ], "modifiers": [], "additional_components": [ "WBGene00001509", "Q23424", "WBGene00001509" ] }, "reaction_10531750": { "compartment": "compartment_74700", "id": "reaction_10531750", "reactome": "R-CEL-1011600", "name": "Rabenosyn-5 connects Rab5 to VPS-45", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10531741", "species_10531705", "species_10531746" ], "products": [ "species_10531748" ], "modifiers": [], "additional_components": [ "WBGene00004268", "WBGene00021538", "WBGene00016643", "H2KYN0", "WBGene00016643", "W6SBE5", "WBGene00021538", "P91857", "WBGene00004268" ] }, "reaction_10531739": { "compartment": "compartment_70101", "id": "reaction_10531739", "reactome": "R-CEL-1011598", "name": "DOCKs bind to RhoGEFs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10531735", "species_10531733" ], "products": [ "species_10531737" ], "modifiers": [], "additional_components": [ "Q05062", "WBGene00000390", "Q03206", "ced-10", "A0A0K3AR51", "F22G12.5c", "Q20487", "WBGene00018520", "G5EEN3", "WBGene00000419", "A0A0K3AR51", "F22G12.5c", "Q20487", "WBGene00018520", "G5EEN3", "WBGene00000419", "Q05062", "WBGene00000390", "Q03206", "ced-10" ] }, "reaction_10531645": { "compartment": "compartment_70101", "id": "reaction_10531645", "reactome": "R-CEL-994148", "name": "LRRC16A binds F-actin capping protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10531641", "species_10528128" ], "products": [ "species_10531643" ], "modifiers": [], "additional_components": [ "WBGene00010641", "P34685", "WBGene00000292", "P34686", "WBGene00000293", "P34685", "WBGene00000292", "P34686", "WBGene00000293", "Q21301", "WBGene00010641" ] }, "reaction_10531709": { "compartment": "compartment_74700", "id": "reaction_10531709", "reactome": "R-CEL-1011576", "name": "EHD proteins interact with Rabenosyn-5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10531705", "species_10531696" ], "products": [ "species_10531707" ], "modifiers": [], "additional_components": [ "WBGene00021538", "WBGene00004373", "G5ECC3", "WBGene00004373", "W6SBE5", "WBGene00021538" ] }, "reaction_10532193": { "compartment": "compartment_70101", "id": "reaction_10532193", "reactome": "R-CEL-1234163", "name": "Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10532190", "species_10532188" ], "products": [ "species_10532186", "species_10532164" ], "modifiers": [ [ "species_10532190", "catalyst" ] ], "additional_components": [ "species_198836", "G5EBV0", "WBGene00001178", "species_113531", "G5ECR7", "WBGene00001235", "Q19213", "WBGene00006922", "Q9BKS1", "WBGene00001236", "Q23457", "WBGene00004320", "Q17390", "WBGene00000837", "G5EGD2", "WBGene00001851", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "P35129", "WBGene00002344", "P91853", "WBGene00006732", "Q17720", "WBGene00006717", "Q20617", "WBGene00006719", "P35129", "WBGene00002344", "P91853", "WBGene00006732", "Q17720", "WBGene00006717", "Q20617", "WBGene00006719", "species_198836", "G5EBV0", "WBGene00001178", "species_113531", "G5ECR7", "WBGene00001235", "Q19213", "WBGene00006922", "Q9BKS1", "WBGene00001236", "Q23457", "WBGene00004320", "Q17390", "WBGene00000837", "G5EGD2", "WBGene00001851", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "species_198836", "G5EBV0", "WBGene00001178", "species_113531", "G5ECR7", "WBGene00001235", "Q19213", "WBGene00006922", "Q9BKS1", "WBGene00001236", "Q23457", "WBGene00004320", "Q17390", "WBGene00000837", "G5EGD2", "WBGene00001851" ] }, "reaction_10532259": { "compartment": "compartment_7660", "id": "reaction_10532259", "reactome": "R-CEL-1234172", "name": "Nuclear VBC complex ubiquitinylates HIF-alpha", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10532252", "species_10532246" ], "products": [ "species_10511544", "species_10532256" ], "modifiers": [ [ "species_10532246", "catalyst" ] ], "additional_components": [ "P35129", "WBGene00002344", "P91853", "WBGene00006732", "Q17720", "WBGene00006717", "Q20617", "WBGene00006719", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "Q9BKS1", "WBGene00001236", "G5ECR7", "WBGene00001235", "Q19213", "WBGene00006922", "Q23457", "WBGene00004320", "Q17390", "WBGene00000837", "G5EGD2", "WBGene00001851", "P35129", "WBGene00002344", "P91853", "WBGene00006732", "Q17720", "WBGene00006717", "Q20617", "WBGene00006719", "Q9BKS1", "WBGene00001236", "G5ECR7", "WBGene00001235", "Q19213", "WBGene00006922", "Q23457", "WBGene00004320", "Q17390", "WBGene00000837", "G5EGD2", "WBGene00001851", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "Q9BKS1", "WBGene00001236", "G5ECR7", "WBGene00001235", "Q19213", "WBGene00006922", "Q23457", "WBGene00004320", "Q17390", "WBGene00000837", "G5EGD2", "WBGene00001851" ] }, "reaction_10532262": { "compartment": "compartment_70101", "id": "reaction_10532262", "reactome": "R-CEL-1234173", "name": "Cytosolic PHD2,3 hydroxylates proline residues on HIF3A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29406", "species_29368", "species_10532176" ], "products": [ "species_10532141", "species_29434", "species_113528" ], "modifiers": [ [ "species_10532162", "catalyst" ] ], "additional_components": [ "WBGene00001851", "WBGene00001851", "species_198836", "G5EBV0", "WBGene00001178", "species_113531", "G5ECR7", "WBGene00001235", "Q19213", "WBGene00006922", "Q9BKS1", "WBGene00001236", "Q23457", "WBGene00004320", "Q17390", "WBGene00000837" ] }, "reaction_10532214": { "compartment": "compartment_7660", "id": "reaction_10532214", "reactome": "R-CEL-1234165", "name": "Nuclear PHD1,3 hydroxylates proline residues on HIF3A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10532182", "species_113671", "species_113685" ], "products": [ "species_10532201", "species_159942", "species_159939" ], "modifiers": [ [ "species_10532211", "catalyst" ] ], "additional_components": [ "WBGene00001851", "WBGene00001851", "species_113531", "species_198836", "G5EBV0", "WBGene00001178" ] }, "reaction_10532248": { "compartment": "compartment_7660", "id": "reaction_10532248", "reactome": "R-CEL-1234169", "name": "Nuclear VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10532234", "species_10532244" ], "products": [ "species_10532246" ], "modifiers": [], "additional_components": [ "WBGene00001851", "Q9BKS1", "WBGene00001236", "G5ECR7", "WBGene00001235", "Q19213", "WBGene00006922", "Q23457", "WBGene00004320", "Q17390", "WBGene00000837", "Q9BKS1", "WBGene00001236", "G5ECR7", "WBGene00001235", "Q19213", "WBGene00006922", "Q23457", "WBGene00004320", "Q17390", "WBGene00000837", "G5EGD2", "WBGene00001851" ] }, "reaction_10532264": { "compartment": "compartment_70101", "id": "reaction_10532264", "reactome": "R-CEL-1234175", "name": "ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10532256" ], "products": [ "species_10532145" ], "modifiers": [], "additional_components": [ "Q9BKS1", "WBGene00001236", "G5ECR7", "WBGene00001235", "Q19213", "WBGene00006922", "Q23457", "WBGene00004320", "Q17390", "WBGene00000837", "G5EGD2", "WBGene00001851", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "G5ECR7", "WBGene00001235", "Q19213", "WBGene00006922", "Q9BKS1", "WBGene00001236", "Q23457", "WBGene00004320", "Q17390", "WBGene00000837", "G5EGD2", "WBGene00001851", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727" ] }, "reaction_10532266": { "compartment": "compartment_70101", "id": "reaction_10532266", "reactome": "R-CEL-1234177", "name": "Cytosolic PHD2,3 hydroxylates proline residues on HIF1A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29406", "species_10532174", "species_29368" ], "products": [ "species_29434", "species_10532138", "species_113528" ], "modifiers": [ [ "species_10532162", "catalyst" ] ], "additional_components": [ "WBGene00001851", "WBGene00001851", "species_198836", "G5EBV0", "WBGene00001178", "species_113531", "G5ECR7", "WBGene00001235", "Q19213", "WBGene00006922", "Q9BKS1", "WBGene00001236", "Q23457", "WBGene00004320", "Q17390", "WBGene00000837" ] }, "reaction_10532170": { "compartment": "compartment_70101", "id": "reaction_10532170", "reactome": "R-CEL-1234159", "name": "Proteasome proteolyzes ub-HIF-alpha", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10532166" ], "products": [ "species_10532168", "species_10502375" ], "modifiers": [ [ "species_10502572", "catalyst" ] ], "additional_components": [ "G5ECR7", "WBGene00001235", "Q19213", "WBGene00006922", "Q9BKS1", "WBGene00001236", "Q23457", "WBGene00004320", "Q17390", "WBGene00000837", "G5EGD2", "WBGene00001851", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "species_198836", "G5EBV0", "WBGene00001178", "species_113531", "species_198836", "G5EBV0", "WBGene00001178", "species_113531", "G5ECR7", "WBGene00001235", "Q19213", "WBGene00006922", "Q9BKS1", "WBGene00001236", "Q23457", "WBGene00004320", "Q17390", "WBGene00000837", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "P91477", "WBGene00003950", "Q95PZ7", "WBGene00013435", "Q18115", "WBGene00004459", "O62102", "WBGene00003948", "O17071", "WBGene00004504", "Q10920", "WBGene00016623", "P34286", "WBGene00003952", "Q9XTT9", "WBGene00004506", "Q23449", "WBGene00004468", "Q95005", "WBGene00003925", "P46502", "WBGene00004503", "O61792", "WBGene00004464", "O17586", "WBGene00003922", "O76371", "WBGene00004505", "Q20585", "WBGene00004463", "Q95008", "WBGene00003926", "Q18787", "WBGene00004501", "Q20058", "WBGene00009445", "Q9N599", "WBGene00003924", "O16368", "WBGene00004502", "O61742", "WBGene00004466", "Q09583", "WBGene00003928", "Q966I8", "WBGene00003947", "Q04908", "WBGene00004460", "Q9XUV0", "WBGene00003951", "Q27488", "WBGene00003923", "Q9GZH5", "WBGene00004458", "O44156", "WBGene00003927", "Q22253", "WBGene00004465", "O76577", "WBGene00004467", "P90868", "WBGene00003953", "Q19324", "WBGene00004461", "Q17971", "WBGene00007588", "Q23237", "WBGene00003949", "Q20938", "WBGene00004462" ] }, "reaction_10532268": { "compartment": "compartment_7660", "id": "reaction_10532268", "reactome": "R-CEL-1234181", "name": "Nuclear PHD1,3 hydroxylates proline residues on HIF1A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113671", "species_113685", "species_10532180" ], "products": [ "species_10532236", "species_159942", "species_159939" ], "modifiers": [ [ "species_10532211", "catalyst" ] ], "additional_components": [ "WBGene00001851", "WBGene00001851", "species_113531", "species_198836", "G5EBV0", "WBGene00001178" ] }, "reaction_10532270": { "compartment": "compartment_70101", "id": "reaction_10532270", "reactome": "R-CEL-1234183", "name": "Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10532134", "species_10532162" ], "products": [ "species_10532190" ], "modifiers": [], "additional_components": [ "WBGene00001851", "species_198836", "G5EBV0", "WBGene00001178", "species_113531", "G5ECR7", "WBGene00001235", "Q19213", "WBGene00006922", "Q9BKS1", "WBGene00001236", "Q23457", "WBGene00004320", "Q17390", "WBGene00000837", "species_198836", "G5EBV0", "WBGene00001178", "species_113531", "G5ECR7", "WBGene00001235", "Q19213", "WBGene00006922", "Q9BKS1", "WBGene00001236", "Q23457", "WBGene00004320", "Q17390", "WBGene00000837", "G5EGD2", "WBGene00001851" ] }, "reaction_10521058": { "compartment": "compartment_70101", "id": "reaction_10521058", "reactome": "R-CEL-392513", "name": "Rap1 signal termination by Rap1GAPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10518164" ], "products": [ "species_111294", "species_10518265" ], "modifiers": [ [ "species_10521051", "catalyst" ], [ "species_10521056", "inhibitor" ] ], "additional_components": [ "Q18246", "WBGene00004307", "species_29438", "Q18246", "WBGene00004307", "species_29420", "H2L2C2", "WBGene00012100", "H2L055", "WBGene00018734", "H2L055", "WBGene00018734", "Q20655", "WBGene00001502", "P41932", "WBGene00003920" ] }, "reaction_10521090": { "compartment": "compartment_70101", "id": "reaction_10521090", "reactome": "R-CEL-392835", "name": "Rap1 sequesters Raf1 to inhibit ERK cascade", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10521086", "species_10518164" ], "products": [ "species_10521088" ], "modifiers": [], "additional_components": [ "WBGene00003030", "Q18246", "WBGene00004307", "species_29438", "Q18246", "WBGene00004307", "species_29438", "Q07292", "WBGene00003030" ] }, "reaction_10528644": { "compartment": "compartment_70101", "id": "reaction_10528644", "reactome": "R-CEL-913993", "name": "14-3-3 proteins beta and zeta bind and inhibit Rap1Gap2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10521054", "species_10521049" ], "products": [ "species_10521056" ], "modifiers": [ [ "species_10528642", "inhibitor" ] ], "additional_components": [ "Q20655", "WBGene00001502", "P41932", "WBGene00003920", "WBGene00018734", "H2L055", "WBGene00018734", "Q20655", "WBGene00001502", "P41932", "WBGene00003920", "WBGene00018734" ] }, "reaction_10521081": { "compartment": "compartment_70101", "id": "reaction_10521081", "reactome": "R-CEL-392834", "name": "Activation of EPACs by cAMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10520078", "species_30389" ], "products": [ "species_10520080" ], "modifiers": [], "additional_components": [ "WBGene00004255", "species_30389", "P34578", "WBGene00004255" ] }, "reaction_10528655": { "compartment": "compartment_70101", "id": "reaction_10528655", "reactome": "R-CEL-913996", "name": "PKA/PKG phosphorylate Rap1GAP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10521049" ], "products": [ "species_29370", "species_10528642" ], "modifiers": [ [ "species_10528652", "catalyst" ] ], "additional_components": [ "WBGene00018734", "WBGene00018734", "O76360", "WBGene00001173", "P21137", "WBGene00002189" ] }, "reaction_10531425": { "compartment": "compartment_70101", "id": "reaction_10531425", "reactome": "R-CEL-983162", "name": "Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_983036" ], "products": [ "species_983032", "species_8942986" ], "modifiers": [ [ "species_10531422", "catalyst" ] ], "additional_components": [ "Q4TT88", "WBGene00003914", "Q9NAA0", "WBGene00022073", "A5A631", "WBGene00022073", "G5EGH4", "WBGene00022073", "H2L0M5", "WBGene00022073", "Q22317", "WBGene00011587", "Q09541", "WBGene00017686" ] }, "reaction_10531346": { "compartment": "compartment_70101", "id": "reaction_10531346", "reactome": "R-CEL-983156", "name": "Polyubiquitination of substrate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10531247", "species_113592", "species_10531253" ], "products": [ "species_111294", "species_10531245", "species_76577", "species_10531312" ], "modifiers": [ [ "species_10531253", "catalyst" ] ], "additional_components": [ "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "P52478", "WBGene00006701", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "O62235", "WBGene00009477", "Q965X6", "WBGene00021369", "Q9N3T6", "WBGene00021640", "Q9N4I6", "WBGene00022115", "Q94251", "WBGene00001089", "Q17531", "WBGene00007206", "Q17962", "WBGene00007574", "O17324", "WBGene00015673", "Q20367", "WBGene00005013", "Q9GYI0", "WBGene00017920", "O45323", "WBGene00008439", "P34284", "WBGene00015350", "Q6A590", "WBGene00020884", "G5EES6", "WBGene00007333", "Q9N3G1", "WBGene00021815", "Q22071", "WBGene00003177", "G5ECU1", "WBGene00004807", "Q17389", "WBGene00000836", "Q23457", "WBGene00004320", "Q965N7", "WBGene00021596", "Q965N6", "WBGene00021597", "L8E6Y3", "WBGene00016407", "P91133", "WBGene00016326", "Q9BL11", "WBGene00021685", "U4PBY0", "WBGene00022069", "B1Q249", "WBGene00015926", "Q9UAQ3", "WBGene00016539", "A0A061ACQ8", "WBGene00022358", "Q20871", "WBGene00021721", "Q20874", "WBGene00021721", "A8DJA6", "WBGene00021721", "P52478", "WBGene00006701", "O62235", "WBGene00009477", "Q965X6", "WBGene00021369", "Q9N3T6", "WBGene00021640", "Q9N4I6", "WBGene00022115", "Q94251", "WBGene00001089", "Q17531", "WBGene00007206", "Q17962", "WBGene00007574", "O17324", "WBGene00015673", "Q20367", "WBGene00005013", "Q9GYI0", "WBGene00017920", "O45323", "WBGene00008439", "P34284", "WBGene00015350", "Q6A590", "WBGene00020884", "G5EES6", "WBGene00007333", "Q9N3G1", "WBGene00021815", "Q22071", "WBGene00003177", "G5ECU1", "WBGene00004807", "Q17389", "WBGene00000836", "Q23457", "WBGene00004320", "Q965N7", "WBGene00021596", "Q965N6", "WBGene00021597", "L8E6Y3", "WBGene00016407", "P91133", "WBGene00016326", "Q9BL11", "WBGene00021685", "U4PBY0", "WBGene00022069", "B1Q249", "WBGene00015926", "Q9UAQ3", "WBGene00016539", "A0A061ACQ8", "WBGene00022358", "Q20871", "WBGene00021721", "Q20874", "WBGene00021721", "A8DJA6", "WBGene00021721", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "O62235", "WBGene00009477", "Q965X6", "WBGene00021369", "Q9N3T6", "WBGene00021640", "Q9N4I6", "WBGene00022115", "Q94251", "WBGene00001089", "Q17531", "WBGene00007206", "Q17962", "WBGene00007574", "O17324", "WBGene00015673", "Q20367", "WBGene00005013", "Q9GYI0", "WBGene00017920", "O45323", "WBGene00008439", "P34284", "WBGene00015350", "Q6A590", "WBGene00020884", "G5EES6", "WBGene00007333", "Q9N3G1", "WBGene00021815", "Q22071", "WBGene00003177", "G5ECU1", "WBGene00004807", "Q17389", "WBGene00000836", "Q23457", "WBGene00004320", "Q965N7", "WBGene00021596", "Q965N6", "WBGene00021597", "L8E6Y3", "WBGene00016407", "P91133", "WBGene00016326", "Q9BL11", "WBGene00021685", "U4PBY0", "WBGene00022069", "B1Q249", "WBGene00015926", "Q9UAQ3", "WBGene00016539", "A0A061ACQ8", "WBGene00022358", "Q20871", "WBGene00021721", "Q20874", "WBGene00021721", "A8DJA6", "WBGene00021721" ] }, "reaction_10531314": { "compartment": "compartment_70101", "id": "reaction_10531314", "reactome": "R-CEL-983147", "name": "Release of E3 from polyubiquitinated substrate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10531312" ], "products": [ "species_983123", "species_10531179" ], "modifiers": [], "additional_components": [ "O62235", "WBGene00009477", "Q965X6", "WBGene00021369", "Q9N3T6", "WBGene00021640", "Q9N4I6", "WBGene00022115", "Q94251", "WBGene00001089", "Q17531", "WBGene00007206", "Q17962", "WBGene00007574", "O17324", "WBGene00015673", "Q20367", "WBGene00005013", "Q9GYI0", "WBGene00017920", "O45323", "WBGene00008439", "P34284", "WBGene00015350", "Q6A590", "WBGene00020884", "G5EES6", "WBGene00007333", "Q9N3G1", "WBGene00021815", "Q22071", "WBGene00003177", "G5ECU1", "WBGene00004807", "Q17389", "WBGene00000836", "Q23457", "WBGene00004320", "Q965N7", "WBGene00021596", "Q965N6", "WBGene00021597", "L8E6Y3", "WBGene00016407", "P91133", "WBGene00016326", "Q9BL11", "WBGene00021685", "U4PBY0", "WBGene00022069", "B1Q249", "WBGene00015926", "Q9UAQ3", "WBGene00016539", "A0A061ACQ8", "WBGene00022358", "Q20871", "WBGene00021721", "Q20874", "WBGene00021721", "A8DJA6", "WBGene00021721", "O62235", "WBGene00009477", "Q965X6", "WBGene00021369", "Q9N3T6", "WBGene00021640", "Q9N4I6", "WBGene00022115", "Q94251", "WBGene00001089", "Q17531", "WBGene00007206", "Q17962", "WBGene00007574", "O17324", "WBGene00015673", "Q20367", "WBGene00005013", "Q9GYI0", "WBGene00017920", "O45323", "WBGene00008439", "P34284", "WBGene00015350", "Q6A590", "WBGene00020884", "G5EES6", "WBGene00007333", "Q9N3G1", "WBGene00021815", "Q22071", "WBGene00003177", "G5ECU1", "WBGene00004807", "Q17389", "WBGene00000836", "Q23457", "WBGene00004320", "Q965N7", "WBGene00021596", "Q965N6", "WBGene00021597", "L8E6Y3", "WBGene00016407", "P91133", "WBGene00016326", "Q9BL11", "WBGene00021685", "U4PBY0", "WBGene00022069", "B1Q249", "WBGene00015926", "Q9UAQ3", "WBGene00016539", "A0A061ACQ8", "WBGene00022358", "Q20871", "WBGene00021721", "Q20874", "WBGene00021721", "A8DJA6", "WBGene00021721" ] }, "reaction_10531348": { "compartment": "compartment_70101", "id": "reaction_10531348", "reactome": "R-CEL-983157", "name": "Interaction of E3 with substrate and E2-Ub complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10531247", "species_10531179", "species_983035" ], "products": [ "species_10531249" ], "modifiers": [], "additional_components": [ "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "P52478", "WBGene00006701", "O62235", "WBGene00009477", "Q965X6", "WBGene00021369", "Q9N3T6", "WBGene00021640", "Q9N4I6", "WBGene00022115", "Q94251", "WBGene00001089", "Q17531", "WBGene00007206", "Q17962", "WBGene00007574", "O17324", "WBGene00015673", "Q20367", "WBGene00005013", "Q9GYI0", "WBGene00017920", "O45323", "WBGene00008439", "P34284", "WBGene00015350", "Q6A590", "WBGene00020884", "G5EES6", "WBGene00007333", "Q9N3G1", "WBGene00021815", "Q22071", "WBGene00003177", "G5ECU1", "WBGene00004807", "Q17389", "WBGene00000836", "Q23457", "WBGene00004320", "Q965N7", "WBGene00021596", "Q965N6", "WBGene00021597", "L8E6Y3", "WBGene00016407", "P91133", "WBGene00016326", "Q9BL11", "WBGene00021685", "U4PBY0", "WBGene00022069", "B1Q249", "WBGene00015926", "Q9UAQ3", "WBGene00016539", "A0A061ACQ8", "WBGene00022358", "Q20871", "WBGene00021721", "Q20874", "WBGene00021721", "A8DJA6", "WBGene00021721", "O62235", "WBGene00009477", "Q965X6", "WBGene00021369", "Q9N3T6", "WBGene00021640", "Q9N4I6", "WBGene00022115", "Q94251", "WBGene00001089", "Q17531", "WBGene00007206", "Q17962", "WBGene00007574", "O17324", "WBGene00015673", "Q20367", "WBGene00005013", "Q9GYI0", "WBGene00017920", "O45323", "WBGene00008439", "P34284", "WBGene00015350", "Q6A590", "WBGene00020884", "G5EES6", "WBGene00007333", "Q9N3G1", "WBGene00021815", "Q22071", "WBGene00003177", "G5ECU1", "WBGene00004807", "Q17389", "WBGene00000836", "Q23457", "WBGene00004320", "Q965N7", "WBGene00021596", "Q965N6", "WBGene00021597", "L8E6Y3", "WBGene00016407", "P91133", "WBGene00016326", "Q9BL11", "WBGene00021685", "U4PBY0", "WBGene00022069", "B1Q249", "WBGene00015926", "Q9UAQ3", "WBGene00016539", "A0A061ACQ8", "WBGene00022358", "Q20871", "WBGene00021721", "Q20874", "WBGene00021721", "A8DJA6", "WBGene00021721", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "P52478", "WBGene00006701" ] }, "reaction_10531316": { "compartment": "compartment_70101", "id": "reaction_10531316", "reactome": "R-CEL-983150", "name": "Proteasomal cleavage of substrate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_983123" ], "products": [ "species_10502375", "species_983032", "species_8942986", "species_983036" ], "modifiers": [ [ "species_10502572", "catalyst" ] ], "additional_components": [ "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "P91477", "WBGene00003950", "Q95PZ7", "WBGene00013435", "Q18115", "WBGene00004459", "O62102", "WBGene00003948", "O17071", "WBGene00004504", "Q10920", "WBGene00016623", "P34286", "WBGene00003952", "Q9XTT9", "WBGene00004506", "Q23449", "WBGene00004468", "Q95005", "WBGene00003925", "P46502", "WBGene00004503", "O61792", "WBGene00004464", "O17586", "WBGene00003922", "O76371", "WBGene00004505", "Q20585", "WBGene00004463", "Q95008", "WBGene00003926", "Q18787", "WBGene00004501", "Q20058", "WBGene00009445", "Q9N599", "WBGene00003924", "O16368", "WBGene00004502", "O61742", "WBGene00004466", "Q09583", "WBGene00003928", "Q966I8", "WBGene00003947", "Q04908", "WBGene00004460", "Q9XUV0", "WBGene00003951", "Q27488", "WBGene00003923", "Q9GZH5", "WBGene00004458", "O44156", "WBGene00003927", "Q22253", "WBGene00004465", "O76577", "WBGene00004467", "P90868", "WBGene00003953", "Q19324", "WBGene00004461", "Q17971", "WBGene00007588", "Q23237", "WBGene00003949", "Q20938", "WBGene00004462" ] }, "reaction_10531256": { "compartment": "compartment_70101", "id": "reaction_10531256", "reactome": "R-CEL-983140", "name": "Transfer of Ub from E2 to substrate and release of E2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10531249" ], "products": [ "species_111294", "species_10531245", "species_10531253", "species_76577" ], "modifiers": [ [ "species_10531179", "catalyst" ] ], "additional_components": [ "O62235", "WBGene00009477", "Q965X6", "WBGene00021369", "Q9N3T6", "WBGene00021640", "Q9N4I6", "WBGene00022115", "Q94251", "WBGene00001089", "Q17531", "WBGene00007206", "Q17962", "WBGene00007574", "O17324", "WBGene00015673", "Q20367", "WBGene00005013", "Q9GYI0", "WBGene00017920", "O45323", "WBGene00008439", "P34284", "WBGene00015350", "Q6A590", "WBGene00020884", "G5EES6", "WBGene00007333", "Q9N3G1", "WBGene00021815", "Q22071", "WBGene00003177", "G5ECU1", "WBGene00004807", "Q17389", "WBGene00000836", "Q23457", "WBGene00004320", "Q965N7", "WBGene00021596", "Q965N6", "WBGene00021597", "L8E6Y3", "WBGene00016407", "P91133", "WBGene00016326", "Q9BL11", "WBGene00021685", "U4PBY0", "WBGene00022069", "B1Q249", "WBGene00015926", "Q9UAQ3", "WBGene00016539", "A0A061ACQ8", "WBGene00022358", "Q20871", "WBGene00021721", "Q20874", "WBGene00021721", "A8DJA6", "WBGene00021721", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "P52478", "WBGene00006701", "P52478", "WBGene00006701", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "O62235", "WBGene00009477", "Q965X6", "WBGene00021369", "Q9N3T6", "WBGene00021640", "Q9N4I6", "WBGene00022115", "Q94251", "WBGene00001089", "Q17531", "WBGene00007206", "Q17962", "WBGene00007574", "O17324", "WBGene00015673", "Q20367", "WBGene00005013", "Q9GYI0", "WBGene00017920", "O45323", "WBGene00008439", "P34284", "WBGene00015350", "Q6A590", "WBGene00020884", "G5EES6", "WBGene00007333", "Q9N3G1", "WBGene00021815", "Q22071", "WBGene00003177", "G5ECU1", "WBGene00004807", "Q17389", "WBGene00000836", "Q23457", "WBGene00004320", "Q965N7", "WBGene00021596", "Q965N6", "WBGene00021597", "L8E6Y3", "WBGene00016407", "P91133", "WBGene00016326", "Q9BL11", "WBGene00021685", "U4PBY0", "WBGene00022069", "B1Q249", "WBGene00015926", "Q9UAQ3", "WBGene00016539", "A0A061ACQ8", "WBGene00022358", "Q20871", "WBGene00021721", "Q20874", "WBGene00021721", "A8DJA6", "WBGene00021721", "O62235", "WBGene00009477", "Q965X6", "WBGene00021369", "Q9N3T6", "WBGene00021640", "Q9N4I6", "WBGene00022115", "Q94251", "WBGene00001089", "Q17531", "WBGene00007206", "Q17962", "WBGene00007574", "O17324", "WBGene00015673", "Q20367", "WBGene00005013", "Q9GYI0", "WBGene00017920", "O45323", "WBGene00008439", "P34284", "WBGene00015350", "Q6A590", "WBGene00020884", "G5EES6", "WBGene00007333", "Q9N3G1", "WBGene00021815", "Q22071", "WBGene00003177", "G5ECU1", "WBGene00004807", "Q17389", "WBGene00000836", "Q23457", "WBGene00004320", "Q965N7", "WBGene00021596", "Q965N6", "WBGene00021597", "L8E6Y3", "WBGene00016407", "P91133", "WBGene00016326", "Q9BL11", "WBGene00021685", "U4PBY0", "WBGene00022069", "B1Q249", "WBGene00015926", "Q9UAQ3", "WBGene00016539", "A0A061ACQ8", "WBGene00022358", "Q20871", "WBGene00021721", "Q20874", "WBGene00021721", "A8DJA6", "WBGene00021721" ] }, "reaction_10531340": { "compartment": "compartment_70101", "id": "reaction_10531340", "reactome": "R-CEL-983152", "name": "Transfer of ubiquitin from E1 to E2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10531245", "species_10531337" ], "products": [ "species_10531247", "species_10531335" ], "modifiers": [ [ "species_10531245", "catalyst" ] ], "additional_components": [ "P52478", "WBGene00006701", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "P52478", "WBGene00006701", "P52478", "WBGene00006701" ] }, "reaction_10531343": { "compartment": "compartment_70101", "id": "reaction_10531343", "reactome": "R-CEL-983153", "name": "E1 mediated ubiquitin activation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10531335", "species_10502375", "species_29926" ], "products": [ "species_111294", "species_10531337", "species_29926", "species_76577" ], "modifiers": [ [ "species_10531335", "catalyst" ] ], "additional_components": [ "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727" ] }, "reaction_10531399": { "compartment": "compartment_17957", "id": "reaction_10531399", "reactome": "R-CEL-983158", "name": "Trimming of peptides in ER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_983034" ], "products": [ "species_8943716", "species_983033" ], "modifiers": [ [ "species_10531396", "catalyst" ] ], "additional_components": [ "Q9NAA0", "WBGene00022073", "A5A631", "WBGene00022073", "G5EGH4", "WBGene00022073", "H2L0M5", "WBGene00022073", "Q22317", "WBGene00011587", "Q4TT88", "WBGene00003914" ] }, "reaction_10531304": { "compartment": "compartment_17957", "id": "reaction_10531304", "reactome": "R-CEL-983144", "name": "Transport of Antigen peptide in to ER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_983032" ], "products": [ "species_29372", "species_29370", "species_983034" ], "modifiers": [ [ "species_10531301", "catalyst" ] ], "additional_components": [ "Q9U275", "WBGene00001817", "O02086", "WBGene00001812", "O18227", "WBGene00001818", "O44897", "WBGene00001819", "Q9TZD9", "WBGene00001814" ] }, "reaction_10515960": { "compartment": "compartment_12045", "id": "reaction_10515960", "reactome": "R-CEL-203979", "name": "Coat Assembly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10515678", "species_10515956" ], "products": [ "species_10515958" ], "modifiers": [], "additional_components": [ "Q23445", "WBGene00022678", "species_29438", "Q9U2Z1", "WBGene00004754", "Q19371", "WBGene00004755", "Q23368", "WBGene00004756", "Q23368", "WBGene00004756", "Q19371", "WBGene00004755", "Q9U2Z1", "WBGene00004754", "Q23445", "WBGene00022678", "species_29438" ] }, "reaction_10543540": { "compartment": "compartment_161320", "id": "reaction_10543540", "reactome": "R-CEL-2213240", "name": "Reduction of disulphide bonds in MHC II antigens", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2213221" ], "products": [ "species_2213225" ], "modifiers": [ [ "species_10543537", "catalyst" ] ], "additional_components": [ "WBGene00015336" ] }, "reaction_10542853": { "compartment": "compartment_161320", "id": "reaction_10542853", "reactome": "R-CEL-2130706", "name": "MHC class II antigen processing", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2213225" ], "products": [ "species_2213226" ], "modifiers": [ [ "species_10542850", "catalyst" ] ], "additional_components": [ "Q21966", "WBGene00000217", "Q93512", "WBGene00019986", "O45734", "WBGene00000776", "Q23030", "WBGene00019986", "O16454", "WBGene00007055" ] }, "reaction_10531914": { "compartment": "compartment_70101", "id": "reaction_10531914", "reactome": "R-CEL-1168373", "name": "PRKCB (Protein kinase C beta, PKC-beta) binds diacylglycerol and phosphatidylserine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_33625", "species_114519", "species_10509541", "species_74016" ], "products": [ "species_10509549" ], "modifiers": [], "additional_components": [ "WBGene00004033", "species_114519", "species_33625", "species_74016", "P90980", "WBGene00004033" ] }, "reaction_10531939": { "compartment": "compartment_876", "id": "reaction_10531939", "reactome": "R-CEL-1168636", "name": "p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10512175", "species_29438" ], "products": [ "species_29420", "species_10511481" ], "modifiers": [ [ "species_10531936", "catalyst" ] ], "additional_components": [ "species_29420", "P22981", "WBGene00002335", "species_29438", "P22981", "WBGene00002335", "species_114519", "Q19770", "WBGene00009100" ] }, "reaction_10520805": { "compartment": "compartment_70101", "id": "reaction_10520805", "reactome": "R-CEL-390329", "name": "Dephosphorylation of AKT by PP2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10513848" ], "products": [ "species_29372", "species_10520802" ], "modifiers": [ [ "species_10513555", "catalyst" ] ], "additional_components": [ "Q9XTG7", "WBGene00000103", "G4S4W1", "WBGene00016980", "Q17941", "WBGene00000102", "G4S4W1", "WBGene00016980", "Q17941", "WBGene00000102", "Q9XTG7", "WBGene00000103" ] }, "reaction_10537056": { "compartment": "compartment_876", "id": "reaction_10537056", "reactome": "R-CEL-1675773", "name": "PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_202247" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10537051", "catalyst" ] ], "additional_components": [ "WBGene00004087" ] }, "reaction_10537312": { "compartment": "compartment_876", "id": "reaction_10537312", "reactome": "R-CEL-1676164", "name": "PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_202247" ], "products": [ "species_1806276", "species_29372" ], "modifiers": [ [ "species_10537307", "catalyst" ] ], "additional_components": [ "Q21623", "WBGene00010975" ] }, "reaction_10537153": { "compartment": "compartment_876", "id": "reaction_10537153", "reactome": "R-CEL-1675836", "name": "PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1806224" ], "products": [ "species_1806276", "species_29372" ], "modifiers": [ [ "species_10537150", "catalyst" ] ], "additional_components": [ "O17590", "WBGene00007620", "G5ECL2", "WBGene00006763" ] }, "reaction_10537283": { "compartment": "compartment_876", "id": "reaction_10537283", "reactome": "R-CEL-1676134", "name": "PI3P is phosphorylated to PI(3,5)P2 by PIP5K1A/B at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806276", "species_113592" ], "products": [ "species_1806224", "species_29370" ], "modifiers": [ [ "species_10537051", "catalyst" ] ], "additional_components": [ "WBGene00004087" ] }, "reaction_10537317": { "compartment": "compartment_876", "id": "reaction_10537317", "reactome": "R-CEL-1676177", "name": "PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_179856" ], "products": [ "species_29372", "species_392417" ], "modifiers": [ [ "species_10537314", "catalyst" ] ], "additional_components": [ "G5ECL2", "WBGene00006763", "G5EGN9", "WBGene00012016", "P34370", "WBGene00086546" ] }, "reaction_10537126": { "compartment": "compartment_876", "id": "reaction_10537126", "reactome": "R-CEL-1675810", "name": "PI is phosphorylated to PI5P by PIP5K1A/B at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_426658" ], "products": [ "species_1806240", "species_29370" ], "modifiers": [ [ "species_10537051", "catalyst" ] ], "additional_components": [ "WBGene00004087" ] }, "reaction_10537222": { "compartment": "compartment_876", "id": "reaction_10537222", "reactome": "R-CEL-1675988", "name": "PI4P is dephosphorylated to PI by SYNJ at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_392417" ], "products": [ "species_29372", "species_426658" ], "modifiers": [ [ "species_10537150", "catalyst" ] ], "additional_components": [ "O17590", "WBGene00007620", "G5ECL2", "WBGene00006763" ] }, "reaction_10563656": { "compartment": "compartment_70101", "id": "reaction_10563656", "reactome": "R-CEL-6809309", "name": "MTMR6 binds MTMR9", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10563629", "species_10537228" ], "products": [ "species_10563654" ], "modifiers": [], "additional_components": [ "WBGene00003479", "F53A2.8a", "G5ED68", "F53A2.8a", "Q965W9", "WBGene00003479" ] }, "reaction_10537291": { "compartment": "compartment_876", "id": "reaction_10537291", "reactome": "R-CEL-1676145", "name": "PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806276", "species_113592" ], "products": [ "species_29370", "species_202247" ], "modifiers": [ [ "species_10537288", "catalyst" ] ], "additional_components": [ "Q9BL73", "WBGene00004088", "O01759", "WBGene00004087" ] }, "reaction_10563661": { "compartment": "compartment_876", "id": "reaction_10563661", "reactome": "R-CEL-6809320", "name": "PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1806224" ], "products": [ "species_29372", "species_1806240" ], "modifiers": [ [ "species_10563658", "catalyst" ] ], "additional_components": [ "G5ED68", "F53A2.8a", "Q965W9", "WBGene00003479" ] }, "reaction_10537325": { "compartment": "compartment_876", "id": "reaction_10537325", "reactome": "R-CEL-1676203", "name": "PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1806224" ], "products": [ "species_29372", "species_1806240" ], "modifiers": [ [ "species_10537230", "catalyst" ] ], "additional_components": [ "Q9N589", "WBGene00003475", "Q22712", "WBGene00003476", "G5ECL2", "WBGene00006763", "G5ED68", "F53A2.8a" ] }, "reaction_10537101": { "compartment": "compartment_876", "id": "reaction_10537101", "reactome": "R-CEL-1675780", "name": "PI is phosphorylated to PI4P by PI4K2A/B at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_426658" ], "products": [ "species_29370", "species_392417" ], "modifiers": [ [ "species_10537098", "catalyst" ] ], "additional_components": [ "O45318", "WBGene00022501", "Q23083", "WBGene00022501" ] }, "reaction_10537294": { "compartment": "compartment_876", "id": "reaction_10537294", "reactome": "R-CEL-1676149", "name": "PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_202247" ], "products": [ "species_29372", "species_392417" ], "modifiers": [ [ "species_10514327", "catalyst" ] ], "additional_components": [ "WBGene00000913" ] }, "reaction_10537264": { "compartment": "compartment_876", "id": "reaction_10537264", "reactome": "R-CEL-1676109", "name": "PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_392417" ], "products": [ "species_29370", "species_202247" ], "modifiers": [ [ "species_10537261", "catalyst" ] ], "additional_components": [ "G5EDP9", "WBGene00000001", "Q94125", "WBGene00000090", "G5EDY0", "WBGene00009552", "species_74016", "species_114632", "species_266099" ] }, "reaction_10563633": { "compartment": "compartment_70101", "id": "reaction_10563633", "reactome": "R-CEL-6809254", "name": "MTMR8 binds MTMR9", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10563629", "species_10563624" ], "products": [ "species_10563631" ], "modifiers": [], "additional_components": [ "WBGene00003479", "F53A2.8a", "G5ED68", "F53A2.8a", "Q965W9", "WBGene00003479" ] }, "reaction_10537233": { "compartment": "compartment_876", "id": "reaction_10537233", "reactome": "R-CEL-1675994", "name": "PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806276", "species_29356" ], "products": [ "species_29372", "species_426658" ], "modifiers": [ [ "species_10537230", "catalyst" ] ], "additional_components": [ "Q9N589", "WBGene00003475", "Q22712", "WBGene00003476", "G5ECL2", "WBGene00006763", "G5ED68", "F53A2.8a" ] }, "reaction_10563664": { "compartment": "compartment_876", "id": "reaction_10563664", "reactome": "R-CEL-6809325", "name": "PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806276", "species_29356" ], "products": [ "species_29372", "species_426658" ], "modifiers": [ [ "species_10563658", "catalyst" ] ], "additional_components": [ "G5ED68", "F53A2.8a", "Q965W9", "WBGene00003479" ] }, "reaction_10567095": { "compartment": "compartment_20699", "id": "reaction_10567095", "reactome": "R-CEL-8870499", "name": "PLEKHA3,8 bind PI4P, ARF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806217", "species_10567091", "species_10517985" ], "products": [ "species_10567093" ], "modifiers": [], "additional_components": [ "WBGene00022347", "WBGene00000183", "G5EFK4", "WBGene00000183", "Q9BKS2", "WBGene00022347", "species_1806234" ] }, "reaction_10537244": { "compartment": "compartment_876", "id": "reaction_10537244", "reactome": "R-CEL-1676048", "name": "PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10537241", "catalyst" ] ], "additional_components": [ "G5EDP9", "WBGene00000001", "Q94125", "WBGene00000090" ] }, "reaction_10537215": { "compartment": "compartment_876", "id": "reaction_10537215", "reactome": "R-CEL-1675949", "name": "PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_179838" ], "products": [ "species_29372", "species_202247" ], "modifiers": [ [ "species_10537212", "catalyst" ] ], "additional_components": [ "G5EGN9", "WBGene00012016", "P34370", "WBGene00086546" ] }, "reaction_10509393": { "compartment": "compartment_7660", "id": "reaction_10509393", "reactome": "R-CEL-113407", "name": "DSIF complex binds to RNA Pol II (hypophosphorylated)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509356", "species_10509234" ], "products": [ "species_10509358" ], "modifiers": [], "additional_components": [ "Q9XUM4", "WBGene00012236", "P16356", "WBGene00000123", "Q19826", "WBGene00017830", "Q9XVH6", "WBGene00012187", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q9U3I0", "WBGene00009078", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q10578", "WBGene00016140", "Q17684", "WBGene00007355", "O02092", "WBGene00018391", "Q9GR61", "WBGene00021347", "Q9N3C9", "WBGene00021845", "Q93338", "WBGene00007971", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "Q9TZ93", "WBGene00005014", "Q21338", "WBGene00005015", "Q9TZ93", "WBGene00005014", "Q21338", "WBGene00005015", "Q9XUM4", "WBGene00012236", "P16356", "WBGene00000123", "Q19826", "WBGene00017830", "Q9XVH6", "WBGene00012187", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q9U3I0", "WBGene00009078", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q10578", "WBGene00016140", "Q17684", "WBGene00007355", "O02092", "WBGene00018391", "Q9GR61", "WBGene00021347", "Q9N3C9", "WBGene00021845", "Q93338", "WBGene00007971", "Q93594", "WBGene00009141", "O01763", "WBGene00018156" ] }, "reaction_10509363": { "compartment": "compartment_7660", "id": "reaction_10509363", "reactome": "R-CEL-112383", "name": "Hypophosphorylation of RNA Pol II CTD by FCP1P protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10506316", "species_10504427", "species_10509239" ], "products": [ "species_10506316", "species_10509356" ], "modifiers": [ [ "species_10509239", "catalyst" ] ], "additional_components": [ "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "WBGene00012236", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q9XUM4", "WBGene00012236", "P16356", "WBGene00000123", "Q19826", "WBGene00017830", "Q9XVH6", "WBGene00012187", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q9U3I0", "WBGene00009078", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q10578", "WBGene00016140", "Q17684", "WBGene00007355", "O02092", "WBGene00018391", "Q9GR61", "WBGene00021347", "Q9N3C9", "WBGene00021845", "Q93338", "WBGene00007971", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "WBGene00012236" ] }, "reaction_10509381": { "compartment": "compartment_7660", "id": "reaction_10509381", "reactome": "R-CEL-112396", "name": "Separation of elongating transcript from template", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509377" ], "products": [ "species_10509379" ], "modifiers": [], "additional_components": [ "Q9TXQ9", "WBGene00017011", "Q9TVL3", "WBGene00000410", "P34424", "WBGene00000508", "P34425", "WBGene00000507", "O17869", "WBGene00009650", "Q9N5R9", "WBGene00018849", "P41848", "WBGene00001974", "species_110614", "species_29358", "species_29494", "species_29438", "P34703", "WBGene00001259", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q9N554", "WBGene00021281", "Q9TZ93", "WBGene00005014", "Q21338", "WBGene00005015", "H2KYV0", "WBGene00016115", "P52652", "WBGene00012000", "Q9XUM4", "WBGene00012236", "Q09413", "WBGene00010990", "Q9BKS1", "WBGene00001236", "G5ECR7", "WBGene00001235", "G5EBY0", "WBGene00009103", "Q03560", "WBGene00007184", "A5Z2V7", "WBGene00008533", "Q17431", "WBGene00007110", "P90783", "WBGene00008338", "Q9N5U5", "WBGene00018064", "Q19375", "WBGene00008729", "Q9TXQ9", "WBGene00017011", "Q9TVL3", "WBGene00000410", "P34424", "WBGene00000508", "P34425", "WBGene00000507", "O17869", "WBGene00009650", "Q9N5R9", "WBGene00018849", "P41848", "WBGene00001974", "species_110614", "species_29358", "species_29494", "species_29438", "P34703", "WBGene00001259", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q9N554", "WBGene00021281", "Q9TZ93", "WBGene00005014", "Q21338", "WBGene00005015", "H2KYV0", "WBGene00016115", "P52652", "WBGene00012000", "Q9XUM4", "WBGene00012236", "Q09413", "WBGene00010990", "Q9BKS1", "WBGene00001236", "G5ECR7", "WBGene00001235", "G5EBY0", "WBGene00009103", "Q03560", "WBGene00007184", "A5Z2V7", "WBGene00008533", "Q17431", "WBGene00007110", "P90783", "WBGene00008338", "Q9N5U5", "WBGene00018064", "Q19375", "WBGene00008729" ] }, "reaction_10509367": { "compartment": "compartment_7660", "id": "reaction_10509367", "reactome": "R-CEL-112385", "name": "Addition of nucleotides leads to transcript elongation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509350", "species_30595" ], "products": [ "species_10506316", "species_10509365" ], "modifiers": [], "additional_components": [ "Q9N5R9", "WBGene00018849", "P41848", "WBGene00001974", "P34703", "WBGene00001259", "H2KYV0", "WBGene00016115", "P52652", "WBGene00012000", "Q09413", "WBGene00010990", "Q9BKS1", "WBGene00001236", "G5ECR7", "WBGene00001235", "G5EBY0", "WBGene00009103", "Q03560", "WBGene00007184", "A5Z2V7", "WBGene00008533", "Q17431", "WBGene00007110", "P90783", "WBGene00008338", "Q9N5U5", "WBGene00018064", "Q9TXQ9", "WBGene00017011", "Q9TVL3", "WBGene00000410", "P34424", "WBGene00000508", "P34425", "WBGene00000507", "O17869", "WBGene00009650", "Q9TZ93", "WBGene00005014", "Q21338", "WBGene00005015", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q9XUM4", "WBGene00012236", "Q9N554", "WBGene00021281", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q19375", "WBGene00008729", "species_110614", "species_29358", "species_29494", "species_29438", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q9TXQ9", "WBGene00017011", "Q9TVL3", "WBGene00000410", "P34424", "WBGene00000508", "P34425", "WBGene00000507", "O17869", "WBGene00009650", "Q9N5R9", "WBGene00018849", "P41848", "WBGene00001974", "species_110614", "species_29358", "species_29494", "species_29438", "P34703", "WBGene00001259", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q9N554", "WBGene00021281", "Q9TZ93", "WBGene00005014", "Q21338", "WBGene00005015", "H2KYV0", "WBGene00016115", "P52652", "WBGene00012000", "Q9XUM4", "WBGene00012236", "Q09413", "WBGene00010990", "Q9BKS1", "WBGene00001236", "G5ECR7", "WBGene00001235", "G5EBY0", "WBGene00009103", "Q03560", "WBGene00007184", "A5Z2V7", "WBGene00008533", "Q17431", "WBGene00007110", "P90783", "WBGene00008338", "Q9N5U5", "WBGene00018064", "Q19375", "WBGene00008729" ] }, "reaction_10509399": { "compartment": "compartment_7660", "id": "reaction_10509399", "reactome": "R-CEL-113412", "name": "Pol II elongation complex moves on the template as transcript elongates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509365", "species_30595" ], "products": [ "species_30595", "species_10509377" ], "modifiers": [], "additional_components": [ "Q9TXQ9", "WBGene00017011", "Q9TVL3", "WBGene00000410", "P34424", "WBGene00000508", "P34425", "WBGene00000507", "O17869", "WBGene00009650", "Q9N5R9", "WBGene00018849", "P41848", "WBGene00001974", "species_110614", "species_29358", "species_29494", "species_29438", "P34703", "WBGene00001259", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q9N554", "WBGene00021281", "Q9TZ93", "WBGene00005014", "Q21338", "WBGene00005015", "H2KYV0", "WBGene00016115", "P52652", "WBGene00012000", "Q9XUM4", "WBGene00012236", "Q09413", "WBGene00010990", "Q9BKS1", "WBGene00001236", "G5ECR7", "WBGene00001235", "G5EBY0", "WBGene00009103", "Q03560", "WBGene00007184", "A5Z2V7", "WBGene00008533", "Q17431", "WBGene00007110", "P90783", "WBGene00008338", "Q9N5U5", "WBGene00018064", "Q19375", "WBGene00008729", "species_110614", "species_29358", "species_29494", "species_29438", "species_110614", "species_29358", "species_29494", "species_29438", "Q9TXQ9", "WBGene00017011", "Q9TVL3", "WBGene00000410", "P34424", "WBGene00000508", "P34425", "WBGene00000507", "O17869", "WBGene00009650", "Q9N5R9", "WBGene00018849", "P41848", "WBGene00001974", "species_110614", "species_29358", "species_29494", "species_29438", "P34703", "WBGene00001259", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q9N554", "WBGene00021281", "Q9TZ93", "WBGene00005014", "Q21338", "WBGene00005015", "H2KYV0", "WBGene00016115", "P52652", "WBGene00012000", "Q9XUM4", "WBGene00012236", "Q09413", "WBGene00010990", "Q9BKS1", "WBGene00001236", "G5ECR7", "WBGene00001235", "G5EBY0", "WBGene00009103", "Q03560", "WBGene00007184", "A5Z2V7", "WBGene00008533", "Q17431", "WBGene00007110", "P90783", "WBGene00008338", "Q9N5U5", "WBGene00018064", "Q19375", "WBGene00008729" ] }, "reaction_10509352": { "compartment": "compartment_7660", "id": "reaction_10509352", "reactome": "R-CEL-112379", "name": "Recruitment of elongation factors to form elongation complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509343", "species_10506316", "species_10509259", "species_10509338", "species_10509306", "species_10509271", "species_10509348", "species_10509283" ], "products": [ "species_10509350" ], "modifiers": [], "additional_components": [ "WBGene00008729", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q9TXQ9", "WBGene00017011", "Q9TVL3", "WBGene00000410", "P34424", "WBGene00000508", "P34425", "WBGene00000507", "O17869", "WBGene00009650", "Q9TZ93", "WBGene00005014", "Q21338", "WBGene00005015", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q9XUM4", "WBGene00012236", "Q9N554", "WBGene00021281", "G5EBY0", "WBGene00009103", "Q03560", "WBGene00007184", "A5Z2V7", "WBGene00008533", "Q17431", "WBGene00007110", "P90783", "WBGene00008338", "Q9N5U5", "WBGene00018064", "Q09413", "WBGene00010990", "Q9BKS1", "WBGene00001236", "G5ECR7", "WBGene00001235", "H2KYV0", "WBGene00016115", "P52652", "WBGene00012000", "WBGene00001259", "Q9N5R9", "WBGene00018849", "P41848", "WBGene00001974", "Q9N5R9", "WBGene00018849", "P41848", "WBGene00001974", "P34703", "WBGene00001259", "H2KYV0", "WBGene00016115", "P52652", "WBGene00012000", "Q09413", "WBGene00010990", "Q9BKS1", "WBGene00001236", "G5ECR7", "WBGene00001235", "G5EBY0", "WBGene00009103", "Q03560", "WBGene00007184", "A5Z2V7", "WBGene00008533", "Q17431", "WBGene00007110", "P90783", "WBGene00008338", "Q9N5U5", "WBGene00018064", "Q9TXQ9", "WBGene00017011", "Q9TVL3", "WBGene00000410", "P34424", "WBGene00000508", "P34425", "WBGene00000507", "O17869", "WBGene00009650", "Q9TZ93", "WBGene00005014", "Q21338", "WBGene00005015", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q9XUM4", "WBGene00012236", "Q9N554", "WBGene00021281", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q19375", "WBGene00008729" ] }, "reaction_10510498": { "compartment": "compartment_876", "id": "reaction_10510498", "reactome": "R-CEL-165026", "name": "OCTN2 / SLC22A5 transports CAR from extracellular space to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_164988", "species_74113" ], "products": [ "species_30235", "species_83910" ], "modifiers": [ [ "species_10510495", "catalyst" ] ], "additional_components": [ "G5EEI9", "WBGene00044455", "Q18795", "WBGene00008271", "G5EGL6", "WBGene00044455", "Q23501", "WBGene00003843", "O18247", "WBGene00044455", "Q4PIX1", "WBGene00044455", "P46499", "WBGene00044455", "Q9BKR9", "WBGene00044455", "Q09617", "WBGene00044455", "A0A0K3AWD3", "WBGene00044455", "Q9U539", "WBGene00003842", "Q18613", "WBGene00044455", "A0A238UKL7", "WBGene00044455", "Q9UAW9", "WBGene00044455", "Q18655", "WBGene00044455" ] }, "reaction_10514514": { "compartment": "compartment_70616", "id": "reaction_10514514", "reactome": "R-CEL-200410", "name": "palmitoylcarnitine + CoASH => palmitoyl-CoA + carnitine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_201050" ], "products": [ "species_201023", "species_77281" ], "modifiers": [ [ "species_10514511", "catalyst" ] ], "additional_components": [ "WBGene00011122" ] }, "reaction_10514597": { "compartment": "compartment_17927", "id": "reaction_10514597", "reactome": "R-CEL-200424", "name": "Exchange of palmitoylcarnitine and carnitine across the inner mitochondrial membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_201023", "species_201034" ], "products": [ "species_549207", "species_201050" ], "modifiers": [ [ "species_10514594", "catalyst" ] ], "additional_components": [ "WBGene00000996" ] }, "reaction_10567572": { "compartment": "compartment_70101", "id": "reaction_10567572", "reactome": "R-CEL-8876889", "name": "Btn-ACACB:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111627", "species_113592", "species_76183" ], "products": [ "species_29372", "species_29370", "species_29508" ], "modifiers": [ [ "species_10514577", "catalyst" ], [ "species_76190", "catalyst" ] ], "additional_components": [ "species_266099", "H2L0M0", "WBGene00004076" ] }, "reaction_10507418": { "compartment": "compartment_70101", "id": "reaction_10507418", "reactome": "R-CEL-75851", "name": "Btn-ACACA:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111627", "species_113592", "species_76183" ], "products": [ "species_29372", "species_29370", "species_29508" ], "modifiers": [ [ "species_10507415", "catalyst" ], [ "species_76190", "catalyst" ] ], "additional_components": [ "Q9XUC3", "WBGene00012131", "H2L0M0", "WBGene00004076", "species_266099" ] }, "reaction_10514589": { "compartment": "compartment_70101", "id": "reaction_10514589", "reactome": "R-CEL-200423", "name": "pAMPK inactivates ACACB, inhibiting malonyl-CoA synthesis", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10514577" ], "products": [ "species_29370", "species_10514584" ], "modifiers": [ [ "species_10514586", "catalyst" ] ], "additional_components": [ "species_266099", "H2L0M0", "WBGene00004076", "H2L0M0", "WBGene00004076", "species_266099", "Q9XUY2", "WBGene00010115", "A0A1T5HUK9", "WBGene00013732", "H2L0K0", "WBGene00020135", "O02168", "WBGene00020633", "Q9N501", "WBGene00021527", "Q95ZQ4", "WBGene00020142" ] }, "reaction_10554146": { "compartment": "compartment_13949", "id": "reaction_10554146", "reactome": "R-CEL-5638014", "name": "RAB11A:GTP-containing Golgi vesicles recruit RAB3IP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10554142", "species_10552808" ], "products": [ "species_10554144" ], "modifiers": [], "additional_components": [ "O01803", "WBGene00004274", "species_29438", "WBGene00010045", "Q20759", "WBGene00010045", "O01803", "WBGene00004274", "species_29438" ] }, "reaction_10517298": { "compartment": "compartment_984", "id": "reaction_10517298", "reactome": "R-CEL-216045", "name": "Collagen type I binds integrin alpha11beta1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10517294", "species_10509625", "species_114632" ], "products": [ "species_10517296" ], "modifiers": [], "additional_components": [ "Q27874", "WBGene00003930", "P34446", "WBGene00003929", "Q9N4U2", "WBGene00000647", "species_114632", "Q9N4U2", "WBGene00000647", "Q27874", "WBGene00003930", "P34446", "WBGene00003929" ] }, "reaction_10549011": { "compartment": "compartment_984", "id": "reaction_10549011", "reactome": "R-CEL-4088264", "name": "Endostatin binds integrin alphaVbeta3, alphaVbeta5, alpha3beta1, alpha5beta1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10549007", "species_10543255" ], "products": [ "species_10549009" ], "modifiers": [], "additional_components": [ "P34446", "WBGene00003929", "Q27874", "WBGene00003930", "Q03600", "WBGene00002081", "WBGene00000702", "Q19368", "WBGene00000702", "P34446", "WBGene00003929", "Q27874", "WBGene00003930", "Q03600", "WBGene00002081" ] }, "reaction_10517427": { "compartment": "compartment_984", "id": "reaction_10517427", "reactome": "R-CEL-216068", "name": "Interaction of integrin alpha9beta1 with Tenascin-C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10517423", "species_10517415" ], "products": [ "species_10517425" ], "modifiers": [], "additional_components": [ "Q27874", "WBGene00003930", "P34446", "WBGene00003929", "Q18096", "WBGene00007687", "Q18096", "WBGene00007687", "Q27874", "WBGene00003930", "P34446", "WBGene00003929" ] }, "reaction_10517398": { "compartment": "compartment_984", "id": "reaction_10517398", "reactome": "R-CEL-216050", "name": "Integrins alpha4beta1, alpha8beta1, alphaVbeta1, alphaVbeta3, alphaVbeta6 bind Fibronectin matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10517394", "species_10517392" ], "products": [ "species_10517396" ], "modifiers": [], "additional_components": [ "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769", "Q27874", "WBGene00003930", "P34446", "WBGene00003929", "Q27874", "WBGene00003930", "P34446", "WBGene00003929", "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769" ] }, "reaction_10544599": { "compartment": "compartment_876", "id": "reaction_10544599", "reactome": "R-CEL-2484965", "name": "Collagen type XIII binds Integrin alpha1beta1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10542932", "species_10543907" ], "products": [ "species_10544597" ], "modifiers": [], "additional_components": [ "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689", "Q27874", "WBGene00003930", "P34446", "WBGene00003929", "Q27874", "WBGene00003930", "P34446", "WBGene00003929", "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689" ] }, "reaction_10517290": { "compartment": "compartment_984", "id": "reaction_10517290", "reactome": "R-CEL-216043", "name": "Collagen type II binds integrin alpha10beta1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_114632", "species_10517286", "species_10517168" ], "products": [ "species_10517288" ], "modifiers": [], "additional_components": [ "O76368", "WBGene00000674", "Q09457", "WBGene00000251", "Q9N4U2", "WBGene00000647", "Q27874", "WBGene00003930", "P34446", "WBGene00003929", "Q27874", "WBGene00003930", "P34446", "WBGene00003929", "O76368", "WBGene00000674", "Q09457", "WBGene00000251", "Q9N4U2", "WBGene00000647", "species_114632" ] }, "reaction_10543915": { "compartment": "compartment_876", "id": "reaction_10543915", "reactome": "R-CEL-2327695", "name": "Collagen types III, IV, V, VI, VIII, IX, XVI bind integrins alpha1beta1 and alpha2beta1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10543911", "species_10543909" ], "products": [ "species_10543913" ], "modifiers": [], "additional_components": [ "Q9N4U2", "WBGene00000647", "O76368", "WBGene00000674", "Q09457", "WBGene00000251", "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689", "P17140", "WBGene00002280", "Q27874", "WBGene00003930", "P34446", "WBGene00003929", "Q27874", "WBGene00003930", "P34446", "WBGene00003929", "Q9N4U2", "WBGene00000647", "O76368", "WBGene00000674", "Q09457", "WBGene00000251", "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689", "P17140", "WBGene00002280" ] }, "reaction_10517419": { "compartment": "compartment_984", "id": "reaction_10517419", "reactome": "R-CEL-216064", "name": "Interaction of integrin alpha8beta1 with Tenascin-C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10517386", "species_10517415" ], "products": [ "species_10517417" ], "modifiers": [], "additional_components": [ "Q27874", "WBGene00003930", "P34446", "WBGene00003929", "Q18096", "WBGene00007687", "Q18096", "WBGene00007687", "Q27874", "WBGene00003930", "P34446", "WBGene00003929" ] }, "reaction_10503155": { "compartment": "compartment_70101", "id": "reaction_10503155", "reactome": "R-CEL-70523", "name": "PXLP-K314-GPT transaminates L-Ala to form PYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29406", "species_29432" ], "products": [ "species_29404", "species_29398" ], "modifiers": [ [ "species_10503152", "catalyst" ] ], "additional_components": [ "O01685", "WBGene00016333" ] }, "reaction_10527117": { "compartment": "compartment_5460", "id": "reaction_10527117", "reactome": "R-CEL-507749", "name": "PXLP-K341-GPT2 transaminates PYR to form L-Ala", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113557", "species_113552" ], "products": [ "species_113594", "species_379697" ], "modifiers": [ [ "species_10527114", "catalyst" ] ], "additional_components": [ "O01685", "WBGene00016333" ] }, "reaction_10522765": { "compartment": "compartment_70101", "id": "reaction_10522765", "reactome": "R-CEL-426520", "name": "Endonucleolytic RISC hydrolyzes target RNAs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426523" ], "products": [ "species_426511" ], "modifiers": [ [ "species_10522752", "catalyst" ] ], "additional_components": [ "G5EES3", "WBGene00000105" ] }, "reaction_10571586": { "compartment": "compartment_70101", "id": "reaction_10571586", "reactome": "R-CEL-9029987", "name": "p-S216-CDC25C translocates to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10507015" ], "products": [ "species_10507019" ], "modifiers": [], "additional_components": [ "WBGene00000389", "WBGene00000389" ] }, "reaction_10507368": { "compartment": "compartment_7660", "id": "reaction_10507368", "reactome": "R-CEL-75809", "name": "Phosphorylation of Cdc25C at Ser216 by CHEK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10507012" ], "products": [ "species_113582", "species_10507015" ], "modifiers": [ [ "species_10502800", "catalyst" ] ], "additional_components": [ "WBGene00000389", "WBGene00000389", "WBGene00000499" ] }, "reaction_10572187": { "compartment": "compartment_7660", "id": "reaction_10572187", "reactome": "R-CEL-9617067", "name": "All-trans retinoic acid binds RARA:RXRA at the promoter of the CEBPE gene", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5334804", "species_10572179" ], "products": [ "species_10572185" ], "modifiers": [], "additional_components": [ "Q9XUK7", "WBGene00003675", "P41830", "WBGene00004786", "Q10902", "WBGene00003601", "Q20765", "WBGene00003606", "Q9U2R6", "WBGene00003681", "Q9XUK7", "WBGene00003675", "P41830", "WBGene00004786", "Q10902", "WBGene00003601", "Q20765", "WBGene00003606", "species_5334816", "Q9U2R6", "WBGene00003681" ] }, "reaction_10520037": { "compartment": "compartment_7660", "id": "reaction_10520037", "reactome": "R-CEL-381262", "name": "Formation of PPARG:RXRA heterodimer (ARF6 complex)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10514477", "species_10519413" ], "products": [ "species_10520035" ], "modifiers": [], "additional_components": [ "WBGene00003681", "Q20765", "WBGene00003606", "Q9XUK7", "WBGene00003675", "P41830", "WBGene00004786", "Q10902", "WBGene00003601", "Q20765", "WBGene00003606", "Q9XUK7", "WBGene00003675", "P41830", "WBGene00004786", "Q10902", "WBGene00003601", "Q9U2R6", "WBGene00003681" ] }, "reaction_10535206": { "compartment": "compartment_7660", "id": "reaction_10535206", "reactome": "R-CEL-1535903", "name": "Phospho R-SMAD(SMAD2/3):CO-SMAD(SMAD4):FOXO3 binds FoxO3a-binding elements", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10511518", "species_1535904", "species_10514276" ], "products": [ "species_10535204" ], "modifiers": [], "additional_components": [ "P45897", "WBGene00004858", "Q21733", "WBGene00000904", "WBGene00000912", "O16850", "WBGene00000912", "P45897", "WBGene00004858", "Q21733", "WBGene00000904" ] }, "reaction_10525296": { "compartment": "compartment_7660", "id": "reaction_10525296", "reactome": "R-CEL-448955", "name": "Phosphorylation of MEF2 proteins by p38", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10525266", "species_10525280" ], "products": [ "species_113582", "species_10525293" ], "modifiers": [ [ "species_10525280", "catalyst" ] ], "additional_components": [ "WBGene00003182", "Q17446", "WBGene00004055", "Q8MXI4", "WBGene00004056", "Q17446", "WBGene00004055", "Q8MXI4", "WBGene00004056", "Q9U325", "WBGene00003182", "Q17446", "WBGene00004055", "Q8MXI4", "WBGene00004056" ] }, "reaction_10525370": { "compartment": "compartment_7660", "id": "reaction_10525370", "reactome": "R-CEL-448963", "name": "Interaction of MyoD:E protein with MEF2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10525291", "species_10525366" ], "products": [ "species_10525368" ], "modifiers": [], "additional_components": [ "Q9U325", "WBGene00003182", "P22980", "WBGene00001948", "G5EEG9", "WBGene00001949", "P22980", "WBGene00001948", "G5EEG9", "WBGene00001949", "Q9U325", "WBGene00003182" ] }, "reaction_10518843": { "compartment": "compartment_876", "id": "reaction_10518843", "reactome": "R-CEL-375138", "name": "CDO binds BOC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10518839", "species_10518837" ], "products": [ "species_10518841" ], "modifiers": [], "additional_components": [ "WBGene00004732", "WBGene00004732", "Q53U87", "WBGene00004732" ] }, "reaction_10525341": { "compartment": "compartment_876", "id": "reaction_10525341", "reactome": "R-CEL-448958", "name": "Nuclear translocation of p38 MAPK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10525339" ], "products": [ "species_10525337", "species_10525280" ], "modifiers": [], "additional_components": [ "P34609", "WBGene00006755", "Q53U87", "WBGene00004732", "O44326", "WBGene00001979", "P90947", "WBGene00001978", "Q05062", "WBGene00000390", "species_29438", "P03949", "WBGene00000018", "Q17446", "WBGene00004055", "Q8MXI4", "WBGene00004056", "P34609", "WBGene00006755", "Q53U87", "WBGene00004732", "O44326", "WBGene00001979", "P90947", "WBGene00001978", "Q05062", "WBGene00000390", "species_29438", "P03949", "WBGene00000018", "Q17446", "WBGene00004055", "Q8MXI4", "WBGene00004056" ] }, "reaction_10544128": { "compartment": "compartment_876", "id": "reaction_10544128", "reactome": "R-CEL-2396029", "name": "Latent TGF-beta-3 binds integrins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10517390", "species_10544124" ], "products": [ "species_10544126" ], "modifiers": [], "additional_components": [ "Q27874", "WBGene00003930", "P34446", "WBGene00003929", "G5EEL5", "WBGene00000936", "G5EBY8", "WBGene00006852", "G5EEL5", "WBGene00000936", "G5EBY8", "WBGene00006852", "Q27874", "WBGene00003930", "P34446", "WBGene00003929" ] }, "reaction_10544040": { "compartment": "compartment_876", "id": "reaction_10544040", "reactome": "R-CEL-2395320", "name": "Latent TGF-beta-1 binds integrins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10544036", "species_10544034" ], "products": [ "species_10544038" ], "modifiers": [], "additional_components": [ "Q27874", "WBGene00003930", "P34446", "WBGene00003929", "G5EBY8", "WBGene00006852", "G5EEL5", "WBGene00000936", "G5EBY8", "WBGene00006852", "G5EEL5", "WBGene00000936", "Q27874", "WBGene00003930", "P34446", "WBGene00003929" ] }, "reaction_10544857": { "compartment": "compartment_984", "id": "reaction_10544857", "reactome": "R-CEL-2537665", "name": "Fibulin-1 and -2 bind fibronectin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10517394", "species_10535682" ], "products": [ "species_10544855" ], "modifiers": [], "additional_components": [ "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769", "WBGene00007170", "Q17494", "WBGene00007170", "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769" ] }, "reaction_10530641": { "compartment": "compartment_70101", "id": "reaction_10530641", "reactome": "R-CEL-977333", "name": "PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_977329", "species_29404" ], "products": [ "species_29406", "species_936706" ], "modifiers": [ [ "species_10530638", "catalyst" ] ], "additional_components": [ "P91856", "WBGene00009177" ] }, "reaction_10530630": { "compartment": "compartment_70101", "id": "reaction_10530630", "reactome": "R-CEL-977324", "name": "PSPH:Mg2+ dimer dephosphorylates O-P-Ser", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_936706" ], "products": [ "species_29372", "species_200736" ], "modifiers": [ [ "species_10530627", "catalyst" ] ], "additional_components": [ "A0A061ACK7", "WBGene00013379", "species_114632" ] }, "reaction_10568102": { "compartment": "compartment_70101", "id": "reaction_10568102", "reactome": "R-CEL-8932980", "name": "SERINC3,5,(1,2,4) transport L-Ser from cytosol to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200736" ], "products": [ "species_8932979" ], "modifiers": [ [ "species_10568099", "catalyst" ] ], "additional_components": [ "Q95XV3", "WBGene00021956", "O45719", "WBGene00021956" ] }, "reaction_10571288": { "compartment": "compartment_70101", "id": "reaction_10571288", "reactome": "R-CEL-9014741", "name": "PXLP-K56-SRR dimer deaminates D-Ser", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_376186" ], "products": [ "species_29356", "species_29382", "species_29398" ], "modifiers": [ [ "species_10571285", "catalyst" ], [ "species_29926", "catalyst" ], [ "species_113592", "catalyst" ] ], "additional_components": [ "Q93968", "WBGene00011353" ] }, "reaction_10571291": { "compartment": "compartment_70101", "id": "reaction_10571291", "reactome": "R-CEL-9014766", "name": "PXLP-K56-SRR dimer isomerises L-Ser to D-Ser", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200736" ], "products": [ "species_376186" ], "modifiers": [ [ "species_10571285", "catalyst" ], [ "species_29926", "catalyst" ], [ "species_113592", "catalyst" ] ], "additional_components": [ "Q93968", "WBGene00011353" ] }, "reaction_10530651": { "compartment": "compartment_70101", "id": "reaction_10530651", "reactome": "R-CEL-977348", "name": "PHGHD tetramer dehydrogenates 3PG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29360", "species_29728" ], "products": [ "species_977329", "species_70106", "species_73473" ], "modifiers": [ [ "species_10530648", "catalyst" ] ], "additional_components": [ "O17626", "WBGene00007836" ] }, "reaction_10571806": { "compartment": "compartment_70101", "id": "reaction_10571806", "reactome": "R-CEL-9034539", "name": "PXLP-K56-SRR dimer deaminates L-Ser", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200736" ], "products": [ "species_29356", "species_29382", "species_29398" ], "modifiers": [ [ "species_10571285", "catalyst" ] ], "additional_components": [ "Q93968", "WBGene00011353" ] }, "reaction_10542969": { "compartment": "compartment_70101", "id": "reaction_10542969", "reactome": "R-CEL-2161195", "name": "abacavir monophosphate + H2O => carbovir monophosphate + cyclopropylamine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_2161194" ], "products": [ "species_2161176", "species_2161175" ], "modifiers": [ [ "species_10542964", "catalyst" ] ], "additional_components": [ "Q8IG39", "WBGene00016632", "species_216785" ] }, "reaction_10543017": { "compartment": "compartment_70101", "id": "reaction_10543017", "reactome": "R-CEL-2162066", "name": "carbovir + IMP => carbovir monophosphate + inosine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2161514", "species_29602" ], "products": [ "species_2161176", "species_83927" ], "modifiers": [ [ "species_10506658", "catalyst" ] ], "additional_components": [ "Q95X21", "WBGene00022201", "species_114632" ] }, "reaction_10543020": { "compartment": "compartment_70101", "id": "reaction_10543020", "reactome": "R-CEL-2162078", "name": "abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2161185", "species_29360" ], "products": [ "species_70106", "species_2162081", "species_73473" ], "modifiers": [ [ "species_10504238", "catalyst" ] ], "additional_components": [ "species_216785", "Q17335", "WBGene00019240" ] }, "reaction_10552511": { "compartment": "compartment_7660", "id": "reaction_10552511", "reactome": "R-CEL-5578742", "name": "AGO1,2:small RNA complexes interact with chromatin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10504431", "species_10552507", "species_10517072" ], "products": [ "species_10552509" ], "modifiers": [], "additional_components": [ "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "G5EES3", "WBGene00000105", "O16720", "WBGene00000106", "O61931", "WBGene00019971", "O62275", "WBGene00010263", "P34681", "WBGene00006449", "Q09249", "WBGene00007624", "Q21691", "WBGene00019862", "Q21770", "WBGene00011061", "Q86NJ8", "WBGene00004093", "Q9N585", "WBGene00004094", "A0A0T7CIX3", "WBGene00019666", "Q9TXN7", "WBGene00020707", "A0A0U1RML5", "WBGene00018921", "Q9XVI3", "WBGene00011945", "D9N120", "WBGene00022877", "G5ED77", "WBGene00011910", "G5EEH0", "WBGene00004323", "H2KZD5", "WBGene00017641", "P62784", "WBGene00001875", "K7ZUH9", "WBGene00001914", "Q10453", "WBGene00001945", "P62784", "WBGene00001875", "K7ZUH9", "WBGene00001914", "Q10453", "WBGene00001945", "G5EES3", "WBGene00000105", "O16720", "WBGene00000106", "O61931", "WBGene00019971", "O62275", "WBGene00010263", "P34681", "WBGene00006449", "Q09249", "WBGene00007624", "Q21691", "WBGene00019862", "Q21770", "WBGene00011061", "Q86NJ8", "WBGene00004093", "Q9N585", "WBGene00004094", "A0A0T7CIX3", "WBGene00019666", "Q9TXN7", "WBGene00020707", "A0A0U1RML5", "WBGene00018921", "Q9XVI3", "WBGene00011945", "D9N120", "WBGene00022877", "G5ED77", "WBGene00011910", "G5EEH0", "WBGene00004323", "H2KZD5", "WBGene00017641", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140" ] }, "reaction_10571531": { "compartment": "compartment_70101", "id": "reaction_10571531", "reactome": "R-CEL-9023912", "name": "AGO2 cleaves passenger strand of duplex siRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10542709" ], "products": [ "species_10571528" ], "modifiers": [ [ "species_10542709", "catalyst" ] ], "additional_components": [ "G5EES3", "WBGene00000105", "G5EES3", "WBGene00000105", "G5EES3", "WBGene00000105" ] }, "reaction_10522748": { "compartment": "compartment_70101", "id": "reaction_10522748", "reactome": "R-CEL-426464", "name": "Dicer cleaves double-stranded RNA to yield double-stranded siRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426463", "species_10515589" ], "products": [ "species_10522745" ], "modifiers": [ [ "species_10515589", "catalyst" ] ], "additional_components": [ "G5EBF5", "WBGene00004326", "P34529", "WBGene00000939", "G5EES3", "WBGene00000105", "P34529", "WBGene00000939", "G5EBF5", "WBGene00004326", "G5EES3", "WBGene00000105", "G5EBF5", "WBGene00004326", "P34529", "WBGene00000939", "G5EES3", "WBGene00000105" ] }, "reaction_10542733": { "compartment": "compartment_70101", "id": "reaction_10542733", "reactome": "R-CEL-2106615", "name": "Removal of siRNA passenger strand", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10542723" ], "products": [ "species_10542731" ], "modifiers": [], "additional_components": [ "G5EBF5", "WBGene00004326", "P34529", "WBGene00000939", "G5EES3", "WBGene00000105", "P34529", "WBGene00000939", "G5EES3", "WBGene00000105", "G5EBF5", "WBGene00004326" ] }, "reaction_10542735": { "compartment": "compartment_70101", "id": "reaction_10542735", "reactome": "R-CEL-2106625", "name": "Duplex siRNA is loaded into Argonaute", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10522745" ], "products": [ "species_10542723" ], "modifiers": [], "additional_components": [ "P34529", "WBGene00000939", "G5EBF5", "WBGene00004326", "G5EES3", "WBGene00000105", "G5EBF5", "WBGene00004326", "P34529", "WBGene00000939", "G5EES3", "WBGene00000105" ] }, "reaction_10536517": { "compartment": "compartment_70101", "id": "reaction_10536517", "reactome": "R-CEL-1614583", "name": "PXLP-K212-CTH cleaves L-Cystathionine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1614518", "species_29356" ], "products": [ "species_111707", "species_29382", "species_936714" ], "modifiers": [ [ "species_10536511", "catalyst" ] ], "additional_components": [ "P55216", "WBGene00022856" ] }, "reaction_10536491": { "compartment": "compartment_70101", "id": "reaction_10536491", "reactome": "R-CEL-1614524", "name": "PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200736", "species_174369" ], "products": [ "species_1614518", "species_29356" ], "modifiers": [ [ "species_10536488", "catalyst" ] ], "additional_components": [ "G5EFH8", "WBGene00013866", "species_71185" ] }, "reaction_10537680": { "compartment": "compartment_7660", "id": "reaction_10537680", "reactome": "R-CEL-1855206", "name": "I(1,3,4,5)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_2023891" ], "products": [ "species_113582", "species_2023901" ], "modifiers": [ [ "species_10537657", "catalyst" ] ], "additional_components": [ "WBGene00014081" ] }, "reaction_10537761": { "compartment": "compartment_7660", "id": "reaction_10537761", "reactome": "R-CEL-1855224", "name": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/2 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_2023940" ], "products": [ "species_113582", "species_2023941" ], "modifiers": [ [ "species_10537560", "catalyst" ] ], "additional_components": [ "O02167", "WBGene00021260", "Q93644", "WBGene00021260", "Q9BKX8", "WBGene00021260" ] }, "reaction_10537683": { "compartment": "compartment_7660", "id": "reaction_10537683", "reactome": "R-CEL-1855207", "name": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/2 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_2023929" ], "products": [ "species_113582", "species_2023940" ], "modifiers": [ [ "species_10537560", "catalyst" ] ], "additional_components": [ "O02167", "WBGene00021260", "Q93644", "WBGene00021260", "Q9BKX8", "WBGene00021260" ] }, "reaction_10537767": { "compartment": "compartment_7660", "id": "reaction_10537767", "reactome": "R-CEL-1855228", "name": "I(1,3,4,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_2023892" ], "products": [ "species_113582", "species_2023901" ], "modifiers": [ [ "species_10537657", "catalyst" ] ], "additional_components": [ "WBGene00014081" ] }, "reaction_10537640": { "compartment": "compartment_7660", "id": "reaction_10537640", "reactome": "R-CEL-1855181", "name": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_2023901" ], "products": [ "species_113582", "species_2023922" ], "modifiers": [ [ "species_10537560", "catalyst" ] ], "additional_components": [ "O02167", "WBGene00021260", "Q93644", "WBGene00021260", "Q9BKX8", "WBGene00021260" ] }, "reaction_10537770": { "compartment": "compartment_7660", "id": "reaction_10537770", "reactome": "R-CEL-1855230", "name": "5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_2023922" ], "products": [ "species_113582", "species_2023948" ], "modifiers": [ [ "species_10537560", "catalyst" ] ], "additional_components": [ "O02167", "WBGene00021260", "Q93644", "WBGene00021260", "Q9BKX8", "WBGene00021260" ] }, "reaction_10537563": { "compartment": "compartment_7660", "id": "reaction_10537563", "reactome": "R-CEL-1855157", "name": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_2023932" ], "products": [ "species_113582", "species_2023931" ], "modifiers": [ [ "species_10537560", "catalyst" ] ], "additional_components": [ "O02167", "WBGene00021260", "Q93644", "WBGene00021260", "Q9BKX8", "WBGene00021260" ] }, "reaction_10537660": { "compartment": "compartment_7660", "id": "reaction_10537660", "reactome": "R-CEL-1855185", "name": "I(1,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_2023935" ], "products": [ "species_113582", "species_2023901" ], "modifiers": [ [ "species_10537657", "catalyst" ] ], "additional_components": [ "WBGene00014081" ] }, "reaction_10537773": { "compartment": "compartment_7660", "id": "reaction_10537773", "reactome": "R-CEL-1855233", "name": "I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by IPMK in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_2023907" ], "products": [ "species_113582", "species_2023891" ], "modifiers": [ [ "species_10537657", "catalyst" ] ], "additional_components": [ "WBGene00014081" ] }, "reaction_10537614": { "compartment": "compartment_7660", "id": "reaction_10537614", "reactome": "R-CEL-1855176", "name": "I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK (IP5-2K) in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_2023901" ], "products": [ "species_113582", "species_2023929" ], "modifiers": [ [ "species_10537611", "catalyst" ] ], "additional_components": [ "WBGene00012466" ] }, "reaction_10509797": { "compartment": "compartment_17951", "id": "reaction_10509797", "reactome": "R-CEL-141348", "name": "PAO:FAD oxidises NASPM to PTCN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113535", "species_141343", "species_141349" ], "products": [ "species_141327", "species_113575", "species_141350" ], "modifiers": [ [ "species_10509794", "catalyst" ] ], "additional_components": [ "O76383", "WBGene00016061", "species_113596" ] }, "reaction_10518005": { "compartment": "compartment_70101", "id": "reaction_10518005", "reactome": "R-CEL-351207", "name": "Spermine => N-acetylated spermine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_353560", "species_76183" ], "products": [ "species_76194", "species_353575" ], "modifiers": [ [ "species_10518002", "catalyst" ] ], "additional_components": [ "WBGene00008408" ] }, "reaction_10518007": { "compartment": "compartment_70101", "id": "reaction_10518007", "reactome": "R-CEL-351208", "name": "Spermidine => N-acetylated spermidine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_204635", "species_76183" ], "products": [ "species_353555", "species_76194" ], "modifiers": [ [ "species_10518002", "catalyst" ] ], "additional_components": [ "WBGene00008408" ] }, "reaction_10509799": { "compartment": "compartment_17951", "id": "reaction_10509799", "reactome": "R-CEL-141351", "name": "PAOX:FAD oxidises NASPN to SPM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113535", "species_141343", "species_141323" ], "products": [ "species_141324", "species_141327", "species_113575" ], "modifiers": [ [ "species_10509794", "catalyst" ] ], "additional_components": [ "O76383", "WBGene00016061", "species_113596" ] }, "reaction_10518160": { "compartment": "compartment_70101", "id": "reaction_10518160", "reactome": "R-CEL-353125", "name": "26S proteosome degrades ODC holoenzyme complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10517946" ], "products": [ "species_10517940" ], "modifiers": [ [ "species_10502572", "catalyst" ] ], "additional_components": [ "Q9NHZ6", "WBGene00022748", "P41931", "WBGene00003844", "O01579", "WBGene00018764", "WBGene00022748", "P91477", "WBGene00003950", "Q95PZ7", "WBGene00013435", "Q18115", "WBGene00004459", "O62102", "WBGene00003948", "O17071", "WBGene00004504", "Q10920", "WBGene00016623", "P34286", "WBGene00003952", "Q9XTT9", "WBGene00004506", "Q23449", "WBGene00004468", "Q95005", "WBGene00003925", "P46502", "WBGene00004503", "O61792", "WBGene00004464", "O17586", "WBGene00003922", "O76371", "WBGene00004505", "Q20585", "WBGene00004463", "Q95008", "WBGene00003926", "Q18787", "WBGene00004501", "Q20058", "WBGene00009445", "Q9N599", "WBGene00003924", "O16368", "WBGene00004502", "O61742", "WBGene00004466", "Q09583", "WBGene00003928", "Q966I8", "WBGene00003947", "Q04908", "WBGene00004460", "Q9XUV0", "WBGene00003951", "Q27488", "WBGene00003923", "Q9GZH5", "WBGene00004458", "O44156", "WBGene00003927", "Q22253", "WBGene00004465", "O76577", "WBGene00004467", "P90868", "WBGene00003953", "Q19324", "WBGene00004461", "Q17971", "WBGene00007588", "Q23237", "WBGene00003949", "Q20938", "WBGene00004462" ] }, "reaction_10517948": { "compartment": "compartment_70101", "id": "reaction_10517948", "reactome": "R-CEL-350567", "name": "Antizyme OAZ binds to Ornithine decarboxylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10503318", "species_10517940" ], "products": [ "species_10517946" ], "modifiers": [], "additional_components": [ "P41931", "WBGene00003844", "O01579", "WBGene00018764", "WBGene00022748", "Q9NHZ6", "WBGene00022748", "P41931", "WBGene00003844", "O01579", "WBGene00018764" ] }, "reaction_10517965": { "compartment": "compartment_70101", "id": "reaction_10517965", "reactome": "R-CEL-350600", "name": "Antizyme inhibitor binds to OAZ and stablizes ODC complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10517946", "species_10517959" ], "products": [ "species_10517963" ], "modifiers": [], "additional_components": [ "Q9NHZ6", "WBGene00022748", "P41931", "WBGene00003844", "O01579", "WBGene00018764", "O01579", "WBGene00018764", "P41931", "WBGene00003844", "P41931", "WBGene00003844", "O01579", "WBGene00018764", "Q9NHZ6", "WBGene00022748" ] }, "reaction_10517953": { "compartment": "compartment_70101", "id": "reaction_10517953", "reactome": "R-CEL-350598", "name": "Arginine<=>Agmatine+CO2", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29468" ], "products": [ "species_113528", "species_351164" ], "modifiers": [ [ "species_10517950", "catalyst" ] ], "additional_components": [ "WBGene00003844" ] }, "reaction_10518023": { "compartment": "compartment_70101", "id": "reaction_10518023", "reactome": "R-CEL-351222", "name": "S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71284" ], "products": [ "species_353113", "species_113528" ], "modifiers": [ [ "species_10518020", "catalyst" ] ], "additional_components": [ "WBGene00004875" ] }, "reaction_10503321": { "compartment": "compartment_70101", "id": "reaction_10503321", "reactome": "R-CEL-70692", "name": "ornithine => putrescine + CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29498" ], "products": [ "species_29610", "species_113528" ], "modifiers": [ [ "species_10503318", "catalyst" ] ], "additional_components": [ "P41931", "WBGene00003844", "O01579", "WBGene00018764" ] }, "reaction_10518015": { "compartment": "compartment_70101", "id": "reaction_10518015", "reactome": "R-CEL-351215", "name": "Putrescine + dc-Adenosyl methionine => Spermidine + 5'-methylthioadenosine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_353113", "species_29610" ], "products": [ "species_204635", "species_353106" ], "modifiers": [ [ "species_10518012", "catalyst" ] ], "additional_components": [ "WBGene00012909" ] }, "reaction_10537235": { "compartment": "compartment_172574", "id": "reaction_10537235", "reactome": "R-CEL-1676024", "name": "PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1806195" ], "products": [ "species_1806198", "species_29370" ], "modifiers": [ [ "species_10537193", "catalyst" ] ], "additional_components": [ "Q9TXI7", "WBGene00006932", "species_266099", "Q23669", "WBGene00014151", "G5EDY0", "WBGene00009552", "species_74016", "species_114632" ] }, "reaction_10537123": { "compartment": "compartment_172574", "id": "reaction_10537123", "reactome": "R-CEL-1675795", "name": "PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806198", "species_29356" ], "products": [ "species_29372", "species_1806195" ], "modifiers": [ [ "species_10537120", "catalyst" ] ], "additional_components": [ "Q9N589", "WBGene00003475", "Q22712", "WBGene00003476", "G5ED68", "F53A2.8a" ] }, "reaction_10537247": { "compartment": "compartment_172574", "id": "reaction_10537247", "reactome": "R-CEL-1676065", "name": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1806289" ], "products": [ "species_1806212", "species_29372" ], "modifiers": [ [ "species_10537120", "catalyst" ] ], "additional_components": [ "Q9N589", "WBGene00003475", "Q22712", "WBGene00003476", "G5ED68", "F53A2.8a" ] }, "reaction_10573048": { "compartment": "compartment_7660", "id": "reaction_10573048", "reactome": "R-CEL-9668902", "name": "Formation of the CTF18-RFC(7s) complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502620", "species_10502635", "species_10511819", "species_10502630", "species_10502625" ], "products": [ "species_10511821" ], "modifiers": [], "additional_components": [ "WBGene00018409", "WBGene00004338", "Q22664", "WBGene00011915", "O44992", "WBGene00019595", "Q21350", "WBGene00010676", "WBGene00004339", "WBGene00004340", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "Q22664", "WBGene00011915", "O44992", "WBGene00019595", "Q21350", "WBGene00010676", "O44175", "WBGene00004338", "P34429", "WBGene00018409" ] }, "reaction_10573050": { "compartment": "compartment_7660", "id": "reaction_10573050", "reactome": "R-CEL-9668904", "name": "Formation of the CTF18 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10511807", "species_10511817", "species_10511812" ], "products": [ "species_10511819" ], "modifiers": [], "additional_components": [ "WBGene00010676", "WBGene00019595", "WBGene00011915", "Q22664", "WBGene00011915", "O44992", "WBGene00019595", "Q21350", "WBGene00010676" ] }, "reaction_10555879": { "compartment": "compartment_7660", "id": "reaction_10555879", "reactome": "R-CEL-5685953", "name": "SIRT6 deacetylates RBBP8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10555871", "species_427523" ], "products": [ "species_427497", "species_427498", "species_10555659" ], "modifiers": [ [ "species_10555876", "catalyst" ] ], "additional_components": [ "Q18606", "WBGene00008082", "Q18606", "WBGene00008082", "WBGene00004803" ] }, "reaction_10506532": { "compartment": "compartment_7660", "id": "reaction_10506532", "reactome": "R-CEL-73946", "name": "Abortive initiation after formation of the first phosphodiester bond", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10506530" ], "products": [ "species_10506316", "species_10506438", "species_10506516", "species_109877", "species_10506433", "species_10504433", "species_10506528" ], "modifiers": [], "additional_components": [ "G5EG49", "WBGene00013998", "G5EG47", "WBGene00010054", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "O44625", "WBGene00004136", "Q9NEX2", "WBGene00013736", "Q95ZS0", "WBGene00006392", "Q9GZI6", "WBGene00006387", "G5EF68", "WBGene00006386", "O45784", "WBGene00006391", "P32085", "WBGene00006542", "O61707", "WBGene00006385", "Q9NEW8", "WBGene00006389", "Q9TYN3", "WBGene00006383", "Q18265", "WBGene00016173", "Q17957", "WBGene00006397", "E9P861", "WBGene00006384", "Q20361", "WBGene00006395", "G5EGM3", "WBGene00006382", "O16991", "WBGene00006648", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "WBGene00006648", "Q95ZS0", "WBGene00006392", "Q9GZI6", "WBGene00006387", "G5EF68", "WBGene00006386", "O45784", "WBGene00006391", "P32085", "WBGene00006542", "O61707", "WBGene00006385", "Q9NEW8", "WBGene00006389", "Q9TYN3", "WBGene00006383", "Q18265", "WBGene00016173", "Q17957", "WBGene00006397", "E9P861", "WBGene00006384", "Q20361", "WBGene00006395", "G5EGM3", "WBGene00006382", "O44625", "WBGene00004136", "Q9NEX2", "WBGene00013736", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "G5EG49", "WBGene00013998", "G5EG47", "WBGene00010054" ] }, "reaction_10509383": { "compartment": "compartment_7660", "id": "reaction_10509383", "reactome": "R-CEL-112429", "name": "Formation of FACT complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509276", "species_10509281" ], "products": [ "species_10509283" ], "modifiers": [], "additional_components": [ "WBGene00001974", "WBGene00018849", "Q9N5R9", "WBGene00018849", "P41848", "WBGene00001974" ] }, "reaction_10509385": { "compartment": "compartment_7660", "id": "reaction_10509385", "reactome": "R-CEL-112430", "name": "Formation of P-TEFb complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509215", "species_10509194" ], "products": [ "species_10509217" ], "modifiers": [], "additional_components": [ "P34424", "WBGene00000508", "P34425", "WBGene00000507", "O17869", "WBGene00009650", "WBGene00000410", "Q9TVL3", "WBGene00000410", "P34424", "WBGene00000508", "P34425", "WBGene00000507", "O17869", "WBGene00009650" ] }, "reaction_10507434": { "compartment": "compartment_7660", "id": "reaction_10507434", "reactome": "R-CEL-75862", "name": "Fall Back to Closed Pre-initiation Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10507424" ], "products": [ "species_10507432" ], "modifiers": [], "additional_components": [ "G5EG49", "WBGene00013998", "G5EG47", "WBGene00010054", "O44625", "WBGene00004136", "Q9NEX2", "WBGene00013736", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q95ZS0", "WBGene00006392", "Q9GZI6", "WBGene00006387", "G5EF68", "WBGene00006386", "O45784", "WBGene00006391", "P32085", "WBGene00006542", "O61707", "WBGene00006385", "Q9NEW8", "WBGene00006389", "Q9TYN3", "WBGene00006383", "Q18265", "WBGene00016173", "Q17957", "WBGene00006397", "E9P861", "WBGene00006384", "Q20361", "WBGene00006395", "G5EGM3", "WBGene00006382", "O16991", "WBGene00006648", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "G5EG49", "WBGene00013998", "G5EG47", "WBGene00010054", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q95ZS0", "WBGene00006392", "Q9GZI6", "WBGene00006387", "G5EF68", "WBGene00006386", "O45784", "WBGene00006391", "P32085", "WBGene00006542", "O61707", "WBGene00006385", "Q9NEW8", "WBGene00006389", "Q9TYN3", "WBGene00006383", "Q18265", "WBGene00016173", "Q17957", "WBGene00006397", "E9P861", "WBGene00006384", "Q20361", "WBGene00006395", "G5EGM3", "WBGene00006382", "O44625", "WBGene00004136", "Q9NEX2", "WBGene00013736", "O16991", "WBGene00006648", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529" ] }, "reaction_10509387": { "compartment": "compartment_7660", "id": "reaction_10509387", "reactome": "R-CEL-112434", "name": "Formation of DSIF complex ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508149", "species_10509232" ], "products": [ "species_10509234" ], "modifiers": [], "additional_components": [ "WBGene00005015", "WBGene00005014", "Q9TZ93", "WBGene00005014", "Q21338", "WBGene00005015" ] }, "reaction_10509389": { "compartment": "compartment_7660", "id": "reaction_10509389", "reactome": "R-CEL-112435", "name": "Formation of Elongin BC complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509293", "species_10509288" ], "products": [ "species_10509295" ], "modifiers": [], "additional_components": [ "WBGene00001235", "WBGene00001236", "Q9BKS1", "WBGene00001236", "G5ECR7", "WBGene00001235" ] }, "reaction_10509391": { "compartment": "compartment_7660", "id": "reaction_10509391", "reactome": "R-CEL-112436", "name": "Formation of Elongin complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509295", "species_10509300" ], "products": [ "species_10509306" ], "modifiers": [], "additional_components": [ "Q9BKS1", "WBGene00001236", "G5ECR7", "WBGene00001235", "WBGene00010990", "Q09413", "WBGene00010990", "Q9BKS1", "WBGene00001236", "G5ECR7", "WBGene00001235" ] }, "reaction_10509395": { "compartment": "compartment_7660", "id": "reaction_10509395", "reactome": "R-CEL-113409", "name": "Abortive termination of early transcription elongation by DSIF:NELF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509360" ], "products": [ "species_10509360" ], "modifiers": [], "additional_components": [ "Q9TZ93", "WBGene00005014", "Q21338", "WBGene00005015", "Q9XUM4", "WBGene00012236", "P16356", "WBGene00000123", "Q19826", "WBGene00017830", "Q9XVH6", "WBGene00012187", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q9U3I0", "WBGene00009078", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q10578", "WBGene00016140", "Q17684", "WBGene00007355", "O02092", "WBGene00018391", "Q9GR61", "WBGene00021347", "Q9N3C9", "WBGene00021845", "Q93338", "WBGene00007971", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "Q9TZ93", "WBGene00005014", "Q21338", "WBGene00005015", "Q9XUM4", "WBGene00012236", "P16356", "WBGene00000123", "Q19826", "WBGene00017830", "Q9XVH6", "WBGene00012187", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q9U3I0", "WBGene00009078", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q10578", "WBGene00016140", "Q17684", "WBGene00007355", "O02092", "WBGene00018391", "Q9GR61", "WBGene00021347", "Q9N3C9", "WBGene00021845", "Q93338", "WBGene00007971", "Q93594", "WBGene00009141", "O01763", "WBGene00018156" ] }, "reaction_10509397": { "compartment": "compartment_7660", "id": "reaction_10509397", "reactome": "R-CEL-113411", "name": "2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509365" ], "products": [ "species_10509369" ], "modifiers": [], "additional_components": [ "Q9TXQ9", "WBGene00017011", "Q9TVL3", "WBGene00000410", "P34424", "WBGene00000508", "P34425", "WBGene00000507", "O17869", "WBGene00009650", "Q9N5R9", "WBGene00018849", "P41848", "WBGene00001974", "species_110614", "species_29358", "species_29494", "species_29438", "P34703", "WBGene00001259", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q9N554", "WBGene00021281", "Q9TZ93", "WBGene00005014", "Q21338", "WBGene00005015", "H2KYV0", "WBGene00016115", "P52652", "WBGene00012000", "Q9XUM4", "WBGene00012236", "Q09413", "WBGene00010990", "Q9BKS1", "WBGene00001236", "G5ECR7", "WBGene00001235", "G5EBY0", "WBGene00009103", "Q03560", "WBGene00007184", "A5Z2V7", "WBGene00008533", "Q17431", "WBGene00007110", "P90783", "WBGene00008338", "Q9N5U5", "WBGene00018064", "Q19375", "WBGene00008729", "Q9TXQ9", "WBGene00017011", "Q9TVL3", "WBGene00000410", "P34424", "WBGene00000508", "P34425", "WBGene00000507", "O17869", "WBGene00009650", "Q9N5R9", "WBGene00018849", "P41848", "WBGene00001974", "P34703", "WBGene00001259", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q9N554", "WBGene00021281", "Q9TZ93", "WBGene00005014", "Q21338", "WBGene00005015", "H2KYV0", "WBGene00016115", "P52652", "WBGene00012000", "Q9XUM4", "WBGene00012236", "Q09413", "WBGene00010990", "Q9BKS1", "WBGene00001236", "G5ECR7", "WBGene00001235", "G5EBY0", "WBGene00009103", "Q03560", "WBGene00007184", "A5Z2V7", "WBGene00008533", "Q17431", "WBGene00007110", "P90783", "WBGene00008338", "Q9N5U5", "WBGene00018064", "Q19375", "WBGene00008729" ] }, "reaction_10509401": { "compartment": "compartment_7660", "id": "reaction_10509401", "reactome": "R-CEL-113413", "name": "TFIIS-mediated recovery of elongation from arrest", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509365" ], "products": [ "species_10509365" ], "modifiers": [], "additional_components": [ "Q9TXQ9", "WBGene00017011", "Q9TVL3", "WBGene00000410", "P34424", "WBGene00000508", "P34425", "WBGene00000507", "O17869", "WBGene00009650", "Q9N5R9", "WBGene00018849", "P41848", "WBGene00001974", "species_110614", "species_29358", "species_29494", "species_29438", "P34703", "WBGene00001259", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q9N554", "WBGene00021281", "Q9TZ93", "WBGene00005014", "Q21338", "WBGene00005015", "H2KYV0", "WBGene00016115", "P52652", "WBGene00012000", "Q9XUM4", "WBGene00012236", "Q09413", "WBGene00010990", "Q9BKS1", "WBGene00001236", "G5ECR7", "WBGene00001235", "G5EBY0", "WBGene00009103", "Q03560", "WBGene00007184", "A5Z2V7", "WBGene00008533", "Q17431", "WBGene00007110", "P90783", "WBGene00008338", "Q9N5U5", "WBGene00018064", "Q19375", "WBGene00008729", "Q9TXQ9", "WBGene00017011", "Q9TVL3", "WBGene00000410", "P34424", "WBGene00000508", "P34425", "WBGene00000507", "O17869", "WBGene00009650", "Q9N5R9", "WBGene00018849", "P41848", "WBGene00001974", "species_110614", "species_29358", "species_29494", "species_29438", "P34703", "WBGene00001259", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q9N554", "WBGene00021281", "Q9TZ93", "WBGene00005014", "Q21338", "WBGene00005015", "H2KYV0", "WBGene00016115", "P52652", "WBGene00012000", "Q9XUM4", "WBGene00012236", "Q09413", "WBGene00010990", "Q9BKS1", "WBGene00001236", "G5ECR7", "WBGene00001235", "G5EBY0", "WBGene00009103", "Q03560", "WBGene00007184", "A5Z2V7", "WBGene00008533", "Q17431", "WBGene00007110", "P90783", "WBGene00008338", "Q9N5U5", "WBGene00018064", "Q19375", "WBGene00008729" ] }, "reaction_10509371": { "compartment": "compartment_7660", "id": "reaction_10509371", "reactome": "R-CEL-112392", "name": "Resumption of elongation after recovery from pausing", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509369" ], "products": [ "species_10509365" ], "modifiers": [], "additional_components": [ "Q9TXQ9", "WBGene00017011", "Q9TVL3", "WBGene00000410", "P34424", "WBGene00000508", "P34425", "WBGene00000507", "O17869", "WBGene00009650", "Q9N5R9", "WBGene00018849", "P41848", "WBGene00001974", "P34703", "WBGene00001259", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q9N554", "WBGene00021281", "Q9TZ93", "WBGene00005014", "Q21338", "WBGene00005015", "H2KYV0", "WBGene00016115", "P52652", "WBGene00012000", "Q9XUM4", "WBGene00012236", "Q09413", "WBGene00010990", "Q9BKS1", "WBGene00001236", "G5ECR7", "WBGene00001235", "G5EBY0", "WBGene00009103", "Q03560", "WBGene00007184", "A5Z2V7", "WBGene00008533", "Q17431", "WBGene00007110", "P90783", "WBGene00008338", "Q9N5U5", "WBGene00018064", "Q19375", "WBGene00008729", "Q9TXQ9", "WBGene00017011", "Q9TVL3", "WBGene00000410", "P34424", "WBGene00000508", "P34425", "WBGene00000507", "O17869", "WBGene00009650", "Q9N5R9", "WBGene00018849", "P41848", "WBGene00001974", "species_110614", "species_29358", "species_29494", "species_29438", "P34703", "WBGene00001259", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q9N554", "WBGene00021281", "Q9TZ93", "WBGene00005014", "Q21338", "WBGene00005015", "H2KYV0", "WBGene00016115", "P52652", "WBGene00012000", "Q9XUM4", "WBGene00012236", "Q09413", "WBGene00010990", "Q9BKS1", "WBGene00001236", "G5ECR7", "WBGene00001235", "G5EBY0", "WBGene00009103", "Q03560", "WBGene00007184", "A5Z2V7", "WBGene00008533", "Q17431", "WBGene00007110", "P90783", "WBGene00008338", "Q9N5U5", "WBGene00018064", "Q19375", "WBGene00008729" ] }, "reaction_10509403": { "compartment": "compartment_7660", "id": "reaction_10509403", "reactome": "R-CEL-113414", "name": "7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509365" ], "products": [ "species_10509365" ], "modifiers": [], "additional_components": [ "Q9TXQ9", "WBGene00017011", "Q9TVL3", "WBGene00000410", "P34424", "WBGene00000508", "P34425", "WBGene00000507", "O17869", "WBGene00009650", "Q9N5R9", "WBGene00018849", "P41848", "WBGene00001974", "species_110614", "species_29358", "species_29494", "species_29438", "P34703", "WBGene00001259", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q9N554", "WBGene00021281", "Q9TZ93", "WBGene00005014", "Q21338", "WBGene00005015", "H2KYV0", "WBGene00016115", "P52652", "WBGene00012000", "Q9XUM4", "WBGene00012236", "Q09413", "WBGene00010990", "Q9BKS1", "WBGene00001236", "G5ECR7", "WBGene00001235", "G5EBY0", "WBGene00009103", "Q03560", "WBGene00007184", "A5Z2V7", "WBGene00008533", "Q17431", "WBGene00007110", "P90783", "WBGene00008338", "Q9N5U5", "WBGene00018064", "Q19375", "WBGene00008729", "Q9TXQ9", "WBGene00017011", "Q9TVL3", "WBGene00000410", "P34424", "WBGene00000508", "P34425", "WBGene00000507", "O17869", "WBGene00009650", "Q9N5R9", "WBGene00018849", "P41848", "WBGene00001974", "species_110614", "species_29358", "species_29494", "species_29438", "P34703", "WBGene00001259", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q9N554", "WBGene00021281", "Q9TZ93", "WBGene00005014", "Q21338", "WBGene00005015", "H2KYV0", "WBGene00016115", "P52652", "WBGene00012000", "Q9XUM4", "WBGene00012236", "Q09413", "WBGene00010990", "Q9BKS1", "WBGene00001236", "G5ECR7", "WBGene00001235", "G5EBY0", "WBGene00009103", "Q03560", "WBGene00007184", "A5Z2V7", "WBGene00008533", "Q17431", "WBGene00007110", "P90783", "WBGene00008338", "Q9N5U5", "WBGene00018064", "Q19375", "WBGene00008729" ] }, "reaction_10507581": { "compartment": "compartment_7660", "id": "reaction_10507581", "reactome": "R-CEL-75891", "name": "Abortive Initiation After Second Transition", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10507579" ], "products": [ "species_10506316", "species_75897", "species_10504433", "species_10506528" ], "modifiers": [], "additional_components": [ "G5EG49", "WBGene00013998", "G5EG47", "WBGene00010054", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "G5EG49", "WBGene00013998", "G5EG47", "WBGene00010054" ] }, "reaction_10507422": { "compartment": "compartment_7660", "id": "reaction_10507422", "reactome": "R-CEL-75856", "name": "Abortive Initiation Before Second Transition", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10507420" ], "products": [ "species_10506316", "species_10506438", "species_110068", "species_10506516", "species_10506433", "species_10504433", "species_10506528" ], "modifiers": [], "additional_components": [ "G5EG49", "WBGene00013998", "G5EG47", "WBGene00010054", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "O44625", "WBGene00004136", "Q9NEX2", "WBGene00013736", "Q95ZS0", "WBGene00006392", "Q9GZI6", "WBGene00006387", "G5EF68", "WBGene00006386", "O45784", "WBGene00006391", "P32085", "WBGene00006542", "O61707", "WBGene00006385", "Q9NEW8", "WBGene00006389", "Q9TYN3", "WBGene00006383", "Q18265", "WBGene00016173", "Q17957", "WBGene00006397", "E9P861", "WBGene00006384", "Q20361", "WBGene00006395", "G5EGM3", "WBGene00006382", "O16991", "WBGene00006648", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "WBGene00006648", "Q95ZS0", "WBGene00006392", "Q9GZI6", "WBGene00006387", "G5EF68", "WBGene00006386", "O45784", "WBGene00006391", "P32085", "WBGene00006542", "O61707", "WBGene00006385", "Q9NEW8", "WBGene00006389", "Q9TYN3", "WBGene00006383", "Q18265", "WBGene00016173", "Q17957", "WBGene00006397", "E9P861", "WBGene00006384", "Q20361", "WBGene00006395", "G5EGM3", "WBGene00006382", "O44625", "WBGene00004136", "Q9NEX2", "WBGene00013736", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "G5EG49", "WBGene00013998", "G5EG47", "WBGene00010054" ] }, "reaction_10509375": { "compartment": "compartment_7660", "id": "reaction_10509375", "reactome": "R-CEL-112395", "name": "Abortive termination of elongation after arrest", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509365" ], "products": [ "species_10509373" ], "modifiers": [], "additional_components": [ "Q9TXQ9", "WBGene00017011", "Q9TVL3", "WBGene00000410", "P34424", "WBGene00000508", "P34425", "WBGene00000507", "O17869", "WBGene00009650", "Q9N5R9", "WBGene00018849", "P41848", "WBGene00001974", "species_110614", "species_29358", "species_29494", "species_29438", "P34703", "WBGene00001259", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q9N554", "WBGene00021281", "Q9TZ93", "WBGene00005014", "Q21338", "WBGene00005015", "H2KYV0", "WBGene00016115", "P52652", "WBGene00012000", "Q9XUM4", "WBGene00012236", "Q09413", "WBGene00010990", "Q9BKS1", "WBGene00001236", "G5ECR7", "WBGene00001235", "G5EBY0", "WBGene00009103", "Q03560", "WBGene00007184", "A5Z2V7", "WBGene00008533", "Q17431", "WBGene00007110", "P90783", "WBGene00008338", "Q9N5U5", "WBGene00018064", "Q19375", "WBGene00008729", "Q9TXQ9", "WBGene00017011", "Q9TVL3", "WBGene00000410", "P34424", "WBGene00000508", "P34425", "WBGene00000507", "O17869", "WBGene00009650", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q9N5R9", "WBGene00018849", "P41848", "WBGene00001974", "P34703", "WBGene00001259", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q9N554", "WBGene00021281", "Q9TZ93", "WBGene00005014", "Q21338", "WBGene00005015", "H2KYV0", "WBGene00016115", "P52652", "WBGene00012000", "Q9XUM4", "WBGene00012236", "Q09413", "WBGene00010990", "Q9BKS1", "WBGene00001236", "G5ECR7", "WBGene00001235", "G5EBY0", "WBGene00009103", "Q03560", "WBGene00007184", "A5Z2V7", "WBGene00008533", "Q17431", "WBGene00007110", "P90783", "WBGene00008338", "Q9N5U5", "WBGene00018064", "Q19375", "WBGene00008729" ] }, "reaction_10517522": { "compartment": "compartment_984", "id": "reaction_10517522", "reactome": "R-CEL-264695", "name": "cholesterol + phosphatidylcholine (lecithin) => cholesterol ester + 2-lysophosphatidylcholine (lysolecithin)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_171149", "species_194276" ], "products": [ "species_194236", "species_171076" ], "modifiers": [ [ "species_10517519", "catalyst" ] ], "additional_components": [ "WBGene00010872" ] }, "reaction_10516629": { "compartment": "compartment_984", "id": "reaction_10516629", "reactome": "R-CEL-210420", "name": "Ca2+ influx through voltage gated Ca2+ channels", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74112" ], "products": [ "species_74016" ], "modifiers": [ [ "species_10516626", "catalyst" ], [ "species_74126", "inhibitor" ] ], "additional_components": [ "A0A3B1E663", "WBGene00006742", "G5EBI8", "WBGene00017400", "G5EDT2", "WBGene00007670", "O01661", "WBGene00000368", "A0A078BQJ0", "WBGene00021125" ] }, "reaction_10565831": { "compartment": "compartment_12045", "id": "reaction_10565831", "reactome": "R-CEL-8857686", "name": "FITM1, FITM2 bind TAGs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_549167", "species_10565825" ], "products": [ "species_10565829" ], "modifiers": [], "additional_components": [ "WBGene00044094", "Q5CZ37", "WBGene00044094", "species_171126" ] }, "reaction_10565903": { "compartment": "compartment_70101", "id": "reaction_10565903", "reactome": "R-CEL-8862380", "name": "HSD17B13 binds lipid droplets", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10556974", "species_8866926" ], "products": [ "species_10565901" ], "modifiers": [], "additional_components": [ "A5JYX5", "WBGene00000967", "O18030", "WBGene00000968", "Q19843", "WBGene00000992", "Q22392", "WBGene00000982", "species_171126", "species_8876704", "CHEBI:16247", "species_171126", "species_8876704", "CHEBI:16247", "A5JYX5", "WBGene00000967", "O18030", "WBGene00000968", "Q19843", "WBGene00000992", "Q22392", "WBGene00000982" ] }, "reaction_10542689": { "compartment": "compartment_17957", "id": "reaction_10542689", "reactome": "R-CEL-2089971", "name": "Secretion of collagens", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10542497" ], "products": [ "species_10542687", "species_10540972" ], "modifiers": [], "additional_components": [ "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "A9Z1L1", "WBGene00005648", "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689", "Q19368", "WBGene00000702", "Q21437", "WBGene00000659", "Q9N4U2", "WBGene00000647", "O76368", "WBGene00000674", "Q09457", "WBGene00000251", "P17140", "WBGene00002280", "Q09457", "WBGene00000251", "Q9N4U2", "WBGene00000647", "O76368", "WBGene00000674", "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689", "P17140", "WBGene00002280", "Q21437", "WBGene00000659", "Q19368", "WBGene00000702", "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "A9Z1L1", "WBGene00005648" ] }, "reaction_10536930": { "compartment": "compartment_17957", "id": "reaction_10536930", "reactome": "R-CEL-1650808", "name": "Prolyl 4-hydroxylase converts collagen prolines to 4-hydroxyprolines", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_10536805", "species_1650779" ], "products": [ "species_1650769", "species_10536918", "species_159751" ], "modifiers": [ [ "species_10536927", "catalyst" ] ], "additional_components": [ "O76368", "WBGene00000674", "Q09457", "WBGene00000251", "Q9N4U2", "WBGene00000647", "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689", "Q17770", "WBGene00003963", "Q17770", "WBGene00003963", "CHEBI:29073", "B1V8J4", "WBGene00012815", "Q17770", "WBGene00003963", "species_113531" ] }, "reaction_10539491": { "compartment": "compartment_12045", "id": "reaction_10539491", "reactome": "R-CEL-1981157", "name": "Glucosylation of collagen propeptide hydroxylysines", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_173594", "species_10539158" ], "products": [ "species_158602", "species_10539488" ], "modifiers": [ [ "species_10538479", "catalyst" ] ], "additional_components": [ "species_113531", "Q20679", "WBGene00002497", "species_113531", "Q20679", "WBGene00002497", "species_113531", "Q20679", "WBGene00002497" ] }, "reaction_10568836": { "compartment": "compartment_17957", "id": "reaction_10568836", "reactome": "R-CEL-8948219", "name": "PLOD3 binds Lysyl hydroxylated collagen propeptides", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10538479", "species_10538808" ], "products": [ "species_10539156" ], "modifiers": [], "additional_components": [ "species_113531", "Q20679", "WBGene00002497", "species_113531", "Q20679", "WBGene00002497" ] }, "reaction_10568838": { "compartment": "compartment_17957", "id": "reaction_10568838", "reactome": "R-CEL-8948222", "name": "PLOD3:Fe2+ dimer:Galactosyl-hydroxylysyl collagen propeptides dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10539158" ], "products": [ "species_10538479", "species_10539149" ], "modifiers": [], "additional_components": [ "species_113531", "Q20679", "WBGene00002497", "species_113531", "Q20679", "WBGene00002497" ] }, "reaction_10568840": { "compartment": "compartment_17957", "id": "reaction_10568840", "reactome": "R-CEL-8948224", "name": "PLOD3:Fe2+ dimer:Glucosyl-galactosyl-hydroxylysyl collagen propeptides dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10539488" ], "products": [ "species_10538479", "species_10539486" ], "modifiers": [], "additional_components": [ "species_113531", "Q20679", "WBGene00002497", "species_113531", "Q20679", "WBGene00002497" ] }, "reaction_10568842": { "compartment": "compartment_17957", "id": "reaction_10568842", "reactome": "R-CEL-8948228", "name": "COLGALT1,COLGALT2 bind Lysyl hydroxylated collagen propeptides", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10538808", "species_10538822" ], "products": [ "species_10538824" ], "modifiers": [], "additional_components": [ "Q18989", "WBGene00008426", "Q18989", "WBGene00008426" ] }, "reaction_10540780": { "compartment": "compartment_984", "id": "reaction_10540780", "reactome": "R-CEL-2002428", "name": "Removal of fibrillar collagen N-propeptides", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10540153" ], "products": [ "species_10540761" ], "modifiers": [ [ "species_10540777", "catalyst" ] ], "additional_components": [ "Q09457", "WBGene00000251", "Q9N4U2", "WBGene00000647", "O76368", "WBGene00000674", "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689", "P17140", "WBGene00002280", "Q21437", "WBGene00000659", "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689", "O76368", "WBGene00000674", "Q09457", "WBGene00000251", "Q9N4U2", "WBGene00000647", "P17140", "WBGene00002280", "Q21437", "WBGene00000659", "Q20176", "WBGene00003555", "O76840", "WBGene00003242" ] }, "reaction_10568844": { "compartment": "compartment_17957", "id": "reaction_10568844", "reactome": "R-CEL-8948231", "name": "COLGALT1,COLGALT2:Galactosyl-hydroxylysyl collagen propeptides dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10539151" ], "products": [ "species_10539149", "species_10538822" ], "modifiers": [], "additional_components": [ "Q18989", "WBGene00008426", "Q18989", "WBGene00008426" ] }, "reaction_10568846": { "compartment": "compartment_17957", "id": "reaction_10568846", "reactome": "R-CEL-8948232", "name": "Lysyl hydroxylated collagen propeptides dissociate from Lysyl hydroxylases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10538810" ], "products": [ "species_10538808", "species_10538481" ], "modifiers": [], "additional_components": [ "Q20679", "WBGene00002497", "species_113531", "Q20679", "WBGene00002497", "species_113531" ] }, "reaction_10568848": { "compartment": "compartment_17957", "id": "reaction_10568848", "reactome": "R-CEL-8948234", "name": "P4HB:4-Hyp collagen propeptides dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10536918" ], "products": [ "species_10536685", "species_10536916" ], "modifiers": [], "additional_components": [ "Q17770", "WBGene00003963", "WBGene00003963" ] }, "reaction_10540785": { "compartment": "compartment_984", "id": "reaction_10540785", "reactome": "R-CEL-2002440", "name": "Removal of fibrillar collagen C-propeptides", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10540761" ], "products": [ "species_10534596" ], "modifiers": [ [ "species_10540775", "catalyst" ] ], "additional_components": [ "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689", "O76368", "WBGene00000674", "Q09457", "WBGene00000251", "Q9N4U2", "WBGene00000647", "P17140", "WBGene00002280", "Q21437", "WBGene00000659", "P17140", "WBGene00002280", "O76368", "WBGene00000674", "Q09457", "WBGene00000251", "Q9N4U2", "WBGene00000647", "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689", "Q21437", "WBGene00000659", "WBGene00003555" ] }, "reaction_10539154": { "compartment": "compartment_17957", "id": "reaction_10539154", "reactome": "R-CEL-1981120", "name": "Galactosylation of collagen propeptide hydroxylysines by procollagen galactosyltransferases 1, 2.", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1981137", "species_10538824" ], "products": [ "species_10539151", "species_158602" ], "modifiers": [ [ "species_10538824", "catalyst" ] ], "additional_components": [ "Q18989", "WBGene00008426", "Q18989", "WBGene00008426", "Q18989", "WBGene00008426" ] }, "reaction_10540787": { "compartment": "compartment_17957", "id": "reaction_10540787", "reactome": "R-CEL-2002460", "name": "P4HB binds Collagen chains", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10536685", "species_10536803" ], "products": [ "species_10536805" ], "modifiers": [], "additional_components": [ "WBGene00003963", "O76368", "WBGene00000674", "Q09457", "WBGene00000251", "Q9N4U2", "WBGene00000647", "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689", "O76368", "WBGene00000674", "Q09457", "WBGene00000251", "Q9N4U2", "WBGene00000647", "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689", "Q17770", "WBGene00003963" ] }, "reaction_10542934": { "compartment": "compartment_17957", "id": "reaction_10542934", "reactome": "R-CEL-2152276", "name": "Secretion of transmembrane collagens", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10540944" ], "products": [ "species_10542932" ], "modifiers": [], "additional_components": [ "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689", "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689" ] }, "reaction_10539161": { "compartment": "compartment_12045", "id": "reaction_10539161", "reactome": "R-CEL-1981128", "name": "Galactosylation of collagen propeptide hydroxylysines by PLOD3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1981137", "species_10539156" ], "products": [ "species_158602", "species_10539158" ], "modifiers": [ [ "species_10538479", "catalyst" ] ], "additional_components": [ "species_113531", "Q20679", "WBGene00002497", "species_113531", "Q20679", "WBGene00002497", "species_113531", "Q20679", "WBGene00002497" ] }, "reaction_10538460": { "compartment": "compartment_17957", "id": "reaction_10538460", "reactome": "R-CEL-1980233", "name": "Collagen prolyl 3-hydroxylase converts 4-Hyp collagen to 3,4-Hyp collagen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_10538344", "species_1650779" ], "products": [ "species_10538457", "species_1650769", "species_159751" ], "modifiers": [ [ "species_10538344", "catalyst" ] ], "additional_components": [ "CHEBI:29073", "species_113531", "CHEBI:29073", "species_113531", "CHEBI:29073", "species_113531" ] }, "reaction_10538813": { "compartment": "compartment_12045", "id": "reaction_10538813", "reactome": "R-CEL-1981104", "name": "Procollagen lysyl hydroxylases convert collagen lysines to 5-hydroxylysines", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_10538483", "species_1650779" ], "products": [ "species_10538810", "species_1650769", "species_159751" ], "modifiers": [ [ "species_10538481", "catalyst" ] ], "additional_components": [ "Q20679", "WBGene00002497", "species_113531", "Q20679", "WBGene00002497", "species_113531", "Q20679", "WBGene00002497", "species_113531" ] }, "reaction_10510320": { "compartment": "compartment_70101", "id": "reaction_10510320", "reactome": "R-CEL-164423", "name": "PhosphoChREBP (Thr 666) is exported to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10510226" ], "products": [ "species_10510224" ], "modifiers": [], "additional_components": [ "WBGene00003378", "WBGene00003378" ] }, "reaction_10510228": { "compartment": "compartment_7660", "id": "reaction_10510228", "reactome": "R-CEL-163670", "name": "Nuclear transport of pChREBP (Thr 666) protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10510224" ], "products": [ "species_10510226" ], "modifiers": [], "additional_components": [ "WBGene00003378", "WBGene00003378" ] }, "reaction_10572971": { "compartment": "compartment_70101", "id": "reaction_10572971", "reactome": "R-CEL-9661405", "name": "ABCC1 transports BIL from cytosol to extracellular region (blood)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189386" ], "products": [ "species_9661418" ], "modifiers": [ [ "species_10517853", "catalyst" ] ], "additional_components": [ "WBGene00003407" ] }, "reaction_10516833": { "compartment": "compartment_984", "id": "reaction_10516833", "reactome": "R-CEL-210439", "name": "glutamate uptake by astrocytes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_210382" ], "products": [ "species_29404" ], "modifiers": [ [ "species_10516830", "catalyst" ] ], "additional_components": [] }, "reaction_10503235": { "compartment": "compartment_70101", "id": "reaction_10503235", "reactome": "R-CEL-70606", "name": "glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29404", "species_113592", "species_31633" ], "products": [ "species_29372", "species_29370", "species_29472" ], "modifiers": [ [ "species_10503232", "catalyst" ] ], "additional_components": [ "Q95YD1", "WBGene00001602", "Q9U307", "WBGene00001604", "O02225", "WBGene00001607", "Q9XVU2", "WBGene00001606", "P34497", "WBGene00001603" ] }, "reaction_10544113": { "compartment": "compartment_70101", "id": "reaction_10544113", "reactome": "R-CEL-2395879", "name": "NUDT18 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2395883", "species_29356" ], "products": [ "species_2395817", "species_29372" ], "modifiers": [ [ "species_10544108", "catalyst" ] ], "additional_components": [ "WBGene00003578" ] }, "reaction_10544116": { "compartment": "compartment_70101", "id": "reaction_10544116", "reactome": "R-CEL-2395965", "name": "NUDT18 hydrolyses 8-OH-dADP to 8-OH-dAMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2395963", "species_29356" ], "products": [ "species_29372", "species_2395964" ], "modifiers": [ [ "species_10544108", "catalyst" ] ], "additional_components": [ "WBGene00003578" ] }, "reaction_10543958": { "compartment": "compartment_5460", "id": "reaction_10543958", "reactome": "R-CEL-2393954", "name": "Mitochondrial NUDT9 hydrolyses ADP-ribose to R5P and AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2393945", "species_113521" ], "products": [ "species_2393950", "species_159448" ], "modifiers": [ [ "species_10543955", "catalyst" ] ], "additional_components": [ "Q09297", "WBGene00003583", "species_114632" ] }, "reaction_10543948": { "compartment": "compartment_70101", "id": "reaction_10543948", "reactome": "R-CEL-2393939", "name": "Cytosolic NUDT5 hydrolyses ADP-ribose to R5P and AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1131972" ], "products": [ "species_73578", "species_76577" ], "modifiers": [ [ "species_10543945", "catalyst" ] ], "additional_components": [ "species_114632", "O61902", "WBGene00003579" ] }, "reaction_10544111": { "compartment": "compartment_70101", "id": "reaction_10544111", "reactome": "R-CEL-2395873", "name": "NUDT18 hydrolyses 8-oxo-GDP to 8-oxo-GMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_2395880" ], "products": [ "species_29372", "species_2395877" ], "modifiers": [ [ "species_10544108", "catalyst" ] ], "additional_components": [ "WBGene00003578" ] }, "reaction_10529189": { "compartment": "compartment_876", "id": "reaction_10529189", "reactome": "R-CEL-917730", "name": "Cargo Recognition And Sorting", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10529158", "species_10529187" ], "products": [ "species_10529160", "species_10529185" ], "modifiers": [], "additional_components": [ "O76258", "WBGene00015658", "Q8WTK0", "WBGene00021771", "Q17687", "WBGene00015508", "O44158", "WBGene00016990", "Q4R133", "WBGene00044542", "Q9NA26", "WBGene00013598", "Q17796", "WBGene00004101", "O01498", "WBGene00004109", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "P49632", "WBGene00006728", "species_179838", "O76258", "WBGene00015658", "Q8WTK0", "WBGene00021771", "Q17687", "WBGene00015508", "O44158", "WBGene00016990", "Q4R133", "WBGene00044542", "Q9NA26", "WBGene00013598", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "P49632", "WBGene00006728", "species_179838", "Q17796", "WBGene00004101", "O01498", "WBGene00004109" ] }, "reaction_10529181": { "compartment": "compartment_70101", "id": "reaction_10529181", "reactome": "R-CEL-917696", "name": "Cargo Sequestration", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10529177", "species_10529160" ], "products": [ "species_10529179", "species_10529158" ], "modifiers": [], "additional_components": [ "Q9U354", "WBGene00012193", "Q19519", "WBGene00008919", "Q18258", "WBGene00016167", "O76258", "WBGene00015658", "Q8WTK0", "WBGene00021771", "Q17687", "WBGene00015508", "O44158", "WBGene00016990", "Q4R133", "WBGene00044542", "Q9NA26", "WBGene00013598", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "P49632", "WBGene00006728", "species_179838", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "P49632", "WBGene00006728", "species_179838", "Q9U354", "WBGene00012193", "Q19519", "WBGene00008919", "Q18258", "WBGene00016167", "O76258", "WBGene00015658", "Q8WTK0", "WBGene00021771", "Q17687", "WBGene00015508", "O44158", "WBGene00016990", "Q4R133", "WBGene00044542", "Q9NA26", "WBGene00013598" ] }, "reaction_10529183": { "compartment": "compartment_70101", "id": "reaction_10529183", "reactome": "R-CEL-917700", "name": "MVB Vesicle Formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10529179", "species_10529080" ], "products": [ "species_10529177", "species_10529112" ], "modifiers": [], "additional_components": [ "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "P49632", "WBGene00006728", "species_179838", "Q9U354", "WBGene00012193", "Q19519", "WBGene00008919", "Q18258", "WBGene00016167", "Q9GYK4", "WBGene00020866", "Q9BL60", "WBGene00022027", "Q9U2F6", "WBGene00012903", "O02208", "WBGene00007216", "Q22718", "WBGene00011976", "Q18886", "WBGene00016961", "Q21959", "WBGene00020025", "Q9U354", "WBGene00012193", "Q19519", "WBGene00008919", "Q18258", "WBGene00016167", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "P49632", "WBGene00006728", "species_179838", "Q9GYK4", "WBGene00020866", "Q9BL60", "WBGene00022027", "Q9U2F6", "WBGene00012903", "O02208", "WBGene00007216", "Q22718", "WBGene00011976", "Q18886", "WBGene00016961", "Q21959", "WBGene00020025" ] }, "reaction_10518835": { "compartment": "compartment_876", "id": "reaction_10518835", "reactome": "R-CEL-374922", "name": "Noradrenalin synaptic vesicle docking and priming", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10516749", "species_10516777", "species_10516744", "species_10518823", "species_10516631", "species_10516739" ], "products": [ "species_10518825" ], "modifiers": [ [ "species_10518823", "catalyst" ] ], "additional_components": [ "WBGene00006798", "Q21049", "WBGene00006364", "Q22366", "WBGene00006750", "P27715", "WBGene00006752", "Q9N415", "WBGene00006513", "WBGene00022271", "Q94057", "WBGene00044062", "Q95XH1", "WBGene00022077", "G5EBK2", "WBGene00014084", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q19767", "WBGene00004898", "Q9GNP0", "WBGene00000295", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "species_209789", "Q94986", "WBGene00004267", "WBGene00006757", "G5EEN8", "WBGene00006454", "A5PEW5", "WBGene00004364", "G5EEN8", "WBGene00006454", "A5PEW5", "WBGene00004364", "Q94057", "WBGene00044062", "Q95XH1", "WBGene00022077", "G5EBK2", "WBGene00014084", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q19767", "WBGene00004898", "Q9GNP0", "WBGene00000295", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "species_209789", "Q94986", "WBGene00004267", "P34815", "WBGene00006757", "Q9GUM7", "WBGene00022271", "Q21049", "WBGene00006364", "Q22366", "WBGene00006750", "P27715", "WBGene00006752", "Q9N415", "WBGene00006513", "O16000", "WBGene00006798", "Q94057", "WBGene00044062", "Q95XH1", "WBGene00022077", "G5EBK2", "WBGene00014084", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q19767", "WBGene00004898", "Q9GNP0", "WBGene00000295", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "species_209789", "Q94986", "WBGene00004267" ] }, "reaction_10518409": { "compartment": "compartment_374932", "id": "reaction_10518409", "reactome": "R-CEL-372542", "name": "Loading of dopamine into synaptic veiscles", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_159362" ], "products": [ "species_351601" ], "modifiers": [ [ "species_10518406", "catalyst" ] ], "additional_components": [ "WBGene00000295" ] }, "reaction_10518830": { "compartment": "compartment_984", "id": "reaction_10518830", "reactome": "R-CEL-374899", "name": "Release of noradrenaline at the synapse", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10518825" ], "products": [ "species_10518827", "species_10516825", "species_10516777", "species_10516744", "species_10516631", "species_10516823", "species_10516807", "species_374935" ], "modifiers": [ [ "species_10518825", "catalyst" ] ], "additional_components": [ "G5EEN8", "WBGene00006454", "A5PEW5", "WBGene00004364", "Q94057", "WBGene00044062", "Q95XH1", "WBGene00022077", "G5EBK2", "WBGene00014084", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q19767", "WBGene00004898", "Q9GNP0", "WBGene00000295", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "species_209789", "Q94986", "WBGene00004267", "P34815", "WBGene00006757", "Q9GUM7", "WBGene00022271", "Q21049", "WBGene00006364", "Q22366", "WBGene00006750", "P27715", "WBGene00006752", "Q9N415", "WBGene00006513", "O16000", "WBGene00006798", "WBGene00000295", "WBGene00004267", "Q21049", "WBGene00006364", "Q22366", "WBGene00006750", "P27715", "WBGene00006752", "Q9N415", "WBGene00006513", "WBGene00022271", "WBGene00006757", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "G5EEN8", "WBGene00006454", "A5PEW5", "WBGene00004364", "Q94057", "WBGene00044062", "Q95XH1", "WBGene00022077", "G5EBK2", "WBGene00014084", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q19767", "WBGene00004898", "O16000", "WBGene00006798", "G5EEN8", "WBGene00006454", "A5PEW5", "WBGene00004364", "Q94057", "WBGene00044062", "Q95XH1", "WBGene00022077", "G5EBK2", "WBGene00014084", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q19767", "WBGene00004898", "Q9GNP0", "WBGene00000295", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "species_209789", "Q94986", "WBGene00004267", "P34815", "WBGene00006757", "Q9GUM7", "WBGene00022271", "Q21049", "WBGene00006364", "Q22366", "WBGene00006750", "P27715", "WBGene00006752", "Q9N415", "WBGene00006513", "O16000", "WBGene00006798" ] }, "reaction_10551442": { "compartment": "compartment_70101", "id": "reaction_10551442", "reactome": "R-CEL-5336443", "name": "LIN7, CASK and APBA1 bind", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10519883", "species_10519878", "species_10519873" ], "products": [ "species_10519889" ], "modifiers": [], "additional_components": [ "WBGene00002996", "WBGene00002991", "WBGene00002999", "O17583", "WBGene00002999", "P54936", "WBGene00002991", "A5PEX5", "WBGene00002996" ] }, "reaction_10519891": { "compartment": "compartment_70101", "id": "reaction_10519891", "reactome": "R-CEL-380574", "name": "Dopamine synaptic vesicle docking and priming", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10519854", "species_10516749", "species_10519865", "species_10516777", "species_10516744", "species_10516631", "species_10516739" ], "products": [ "species_10519867" ], "modifiers": [ [ "species_10519854", "catalyst" ], [ "species_10519889", "catalyst" ] ], "additional_components": [ "species_351601", "Q94057", "WBGene00044062", "Q95XH1", "WBGene00022077", "G5EBK2", "WBGene00014084", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q19767", "WBGene00004898", "Q9GNP0", "WBGene00000295", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "Q94986", "WBGene00004267", "WBGene00006798", "Q21049", "WBGene00006364", "Q22366", "WBGene00006750", "P27715", "WBGene00006752", "Q9N415", "WBGene00006513", "WBGene00022271", "WBGene00006757", "G5EEN8", "WBGene00006454", "A5PEW5", "WBGene00004364", "G5EEN8", "WBGene00006454", "A5PEW5", "WBGene00004364", "P34815", "WBGene00006757", "Q9GUM7", "WBGene00022271", "Q21049", "WBGene00006364", "Q22366", "WBGene00006750", "P27715", "WBGene00006752", "Q9N415", "WBGene00006513", "O16000", "WBGene00006798", "species_351601", "Q94057", "WBGene00044062", "Q95XH1", "WBGene00022077", "G5EBK2", "WBGene00014084", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q19767", "WBGene00004898", "Q9GNP0", "WBGene00000295", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "Q94986", "WBGene00004267", "species_351601", "Q94057", "WBGene00044062", "Q95XH1", "WBGene00022077", "G5EBK2", "WBGene00014084", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q19767", "WBGene00004898", "Q9GNP0", "WBGene00000295", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "Q94986", "WBGene00004267", "O17583", "WBGene00002999", "P54936", "WBGene00002991", "A5PEX5", "WBGene00002996" ] }, "reaction_10519942": { "compartment": "compartment_984", "id": "reaction_10519942", "reactome": "R-CEL-380869", "name": "Release of docked dopamine loaded synaptic vesicle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10519867" ], "products": [ "species_380873", "species_10518827", "species_10516777", "species_10516825", "species_10519865", "species_10516744", "species_10516823", "species_10516631", "species_10516807" ], "modifiers": [ [ "species_10519867", "catalyst" ] ], "additional_components": [ "G5EEN8", "WBGene00006454", "A5PEW5", "WBGene00004364", "P34815", "WBGene00006757", "Q9GUM7", "WBGene00022271", "Q21049", "WBGene00006364", "Q22366", "WBGene00006750", "P27715", "WBGene00006752", "Q9N415", "WBGene00006513", "O16000", "WBGene00006798", "species_351601", "Q94057", "WBGene00044062", "Q95XH1", "WBGene00022077", "G5EBK2", "WBGene00014084", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q19767", "WBGene00004898", "Q9GNP0", "WBGene00000295", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "Q94986", "WBGene00004267", "WBGene00000295", "Q21049", "WBGene00006364", "Q22366", "WBGene00006750", "P27715", "WBGene00006752", "Q9N415", "WBGene00006513", "WBGene00004267", "WBGene00022271", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "WBGene00006757", "G5EEN8", "WBGene00006454", "A5PEW5", "WBGene00004364", "Q94057", "WBGene00044062", "Q95XH1", "WBGene00022077", "G5EBK2", "WBGene00014084", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q19767", "WBGene00004898", "O16000", "WBGene00006798", "G5EEN8", "WBGene00006454", "A5PEW5", "WBGene00004364", "P34815", "WBGene00006757", "Q9GUM7", "WBGene00022271", "Q21049", "WBGene00006364", "Q22366", "WBGene00006750", "P27715", "WBGene00006752", "Q9N415", "WBGene00006513", "O16000", "WBGene00006798", "species_351601", "Q94057", "WBGene00044062", "Q95XH1", "WBGene00022077", "G5EBK2", "WBGene00014084", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q19767", "WBGene00004898", "Q9GNP0", "WBGene00000295", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "Q94986", "WBGene00004267" ] }, "reaction_10563003": { "compartment": "compartment_161320", "id": "reaction_10563003", "reactome": "R-CEL-6803753", "name": "NAAA hydrolyses NAEs to FAs and ethanolamine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_6803725" ], "products": [ "species_6803745", "species_6803778" ], "modifiers": [ [ "species_10563000", "catalyst" ] ], "additional_components": [ "CHEBI:71466", "species_5693752", "CHEBI:85299", "CHEBI:85263", "CHEBI:71464", "CHEBI:85262", "species_390435", "species_33549", "species_8934421", "CHEBI:28875", "CHEBI:16196", "species_422506", "Q9GUI1", "WBGene00021917" ] }, "reaction_10565443": { "compartment": "compartment_161320", "id": "reaction_10565443", "reactome": "R-CEL-8853686", "name": "MAN2B1 hydrolyses GlcNAc (Man)5 to GlcNAc (Man)3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_8853396" ], "products": [ "species_6799577", "species_6799594" ], "modifiers": [ [ "species_10565440", "catalyst" ] ], "additional_components": [ "Q20829", "WBGene00018877", "species_216785" ] }, "reaction_10565448": { "compartment": "compartment_161320", "id": "reaction_10565448", "reactome": "R-CEL-8853710", "name": "MANBA hydrolyses GlcNAc:Man", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8853719" ], "products": [ "species_1678743", "species_6799594" ], "modifiers": [ [ "species_10565445", "catalyst" ] ], "additional_components": [ "WBGene00007904" ] }, "reaction_10562091": { "compartment": "compartment_161320", "id": "reaction_10562091", "reactome": "R-CEL-6799581", "name": "MAN2B2 hydrolyses GlcNAc (Man)3 to GlcNAc:Man", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6799577", "species_1605715" ], "products": [ "species_6799594", "species_8853719" ], "modifiers": [ [ "species_10562088", "catalyst" ] ], "additional_components": [ "Q20829", "WBGene00018877", "species_216785" ] }, "reaction_10554447": { "compartment": "compartment_7660", "id": "reaction_10554447", "reactome": "R-CEL-5655892", "name": "POLK incorporates dNMP opposite to damaged DNA base", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30555", "species_10554438" ], "products": [ "species_10554444", "species_113541" ], "modifiers": [ [ "species_10554438", "catalyst" ] ], "additional_components": [ "species_266099", "species_114632", "P34409", "WBGene00017696", "Q95Y97", "WBGene00019767", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "O02115", "WBGene00003955", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "Q09615", "WBGene00014066", "A0A0K3AUS7", "WBGene00021344", "species_266099", "species_114632", "P34409", "WBGene00017696", "Q09615", "WBGene00014066", "Q95Y97", "WBGene00019767", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "O02115", "WBGene00003955", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "A0A0K3AUS7", "WBGene00021344", "species_266099", "species_114632", "P34409", "WBGene00017696", "Q95Y97", "WBGene00019767", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "O02115", "WBGene00003955", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "Q09615", "WBGene00014066", "A0A0K3AUS7", "WBGene00021344" ] }, "reaction_10506096": { "compartment": "compartment_70101", "id": "reaction_10506096", "reactome": "R-CEL-73591", "name": "beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_73588" ], "products": [ "species_113528", "species_73590", "species_31633" ], "modifiers": [ [ "species_10506093", "catalyst" ] ], "additional_components": [ "species_216785", "Q19437", "WBGene00017440" ] }, "reaction_10506128": { "compartment": "compartment_70101", "id": "reaction_10506128", "reactome": "R-CEL-73616", "name": "thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_83960", "species_29364" ], "products": [ "species_29366", "species_73541" ], "modifiers": [ [ "species_10506073", "catalyst" ] ], "additional_components": [ "species_73524", "Q18164", "WBGene00016103", "species_113596" ] }, "reaction_10506130": { "compartment": "compartment_70101", "id": "reaction_10506130", "reactome": "R-CEL-73618", "name": "5,6-dihydrothymine + H2O => beta-ureidoisobutyrate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_73541" ], "products": [ "species_73617" ], "modifiers": [ [ "species_10506083", "catalyst" ] ], "additional_components": [ "Q18677", "WBGene00000964", "species_216785" ] }, "reaction_10506132": { "compartment": "compartment_70101", "id": "reaction_10506132", "reactome": "R-CEL-73620", "name": "beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_73617" ], "products": [ "species_113528", "species_73619", "species_31633" ], "modifiers": [ [ "species_10506093", "catalyst" ] ], "additional_components": [ "species_216785", "Q19437", "WBGene00017440" ] }, "reaction_10506086": { "compartment": "compartment_70101", "id": "reaction_10506086", "reactome": "R-CEL-73589", "name": "5,6-dihydrouracil + H2O => beta-ureidopropionate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_73584" ], "products": [ "species_73588" ], "modifiers": [ [ "species_10506083", "catalyst" ] ], "additional_components": [ "Q18677", "WBGene00000964", "species_216785" ] }, "reaction_10506681": { "compartment": "compartment_70101", "id": "reaction_10506681", "reactome": "R-CEL-74376", "name": "(deoxy)uridine + orthophosphate <=> uracil + (deoxy)ribose 1-phosphate (UPP)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29372", "species_500430" ], "products": [ "species_83962", "species_500244" ], "modifiers": [ [ "species_10506676", "catalyst" ] ], "additional_components": [ "CHEBI:16450", "CHEBI:16704", "CHEBI:28542", "species_112016", "Q23588", "WBGene00022817" ] }, "reaction_10506076": { "compartment": "compartment_70101", "id": "reaction_10506076", "reactome": "R-CEL-73585", "name": "uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_83962", "species_29364" ], "products": [ "species_29366", "species_73584" ], "modifiers": [ [ "species_10506073", "catalyst" ] ], "additional_components": [ "species_73524", "Q18164", "WBGene00016103", "species_113596" ] }, "reaction_10508397": { "compartment": "compartment_70101", "id": "reaction_10508397", "reactome": "R-CEL-109449", "name": "(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C3)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_500347" ], "products": [ "species_500346", "species_29372" ], "modifiers": [ [ "species_10508394", "catalyst" ] ], "additional_components": [ "species_109395", "CHEBI:15918", "species_109366", "species_500742", "species_109402", "CHEBI:15698", "CHEBI:16450", "CHEBI:16704", "species_83928", "CHEBI:17562", "species_114632", "Q09315", "WBGene00017775", "Q95ZJ9", "WBGene00017775" ] }, "reaction_10506641": { "compartment": "compartment_70101", "id": "reaction_10506641", "reactome": "R-CEL-74242", "name": "(deoxy)inosine + orthophosphate <=> hypoxanthine + (deoxy)ribose 1-phosphate (NP)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29372", "species_500172" ], "products": [ "species_113599", "species_500244" ], "modifiers": [ [ "species_10506638", "catalyst" ] ], "additional_components": [ "CHEBI:28997", "species_83927", "CHEBI:28542", "species_112016", "U4PSA1", "WBGene00019298" ] }, "reaction_10544722": { "compartment": "compartment_70101", "id": "reaction_10544722", "reactome": "R-CEL-2509838", "name": "ITPA hydrolyses dITP to dIMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2509835", "species_29356" ], "products": [ "species_111294", "species_109330" ], "modifiers": [ [ "species_10544713", "catalyst" ], [ "species_29926", "catalyst" ] ], "additional_components": [ "Q9GYG4", "WBGene00001823" ] }, "reaction_10506661": { "compartment": "compartment_70101", "id": "reaction_10506661", "reactome": "R-CEL-74248", "name": "(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_500120", "species_29356" ], "products": [ "species_29372", "species_500118" ], "modifiers": [ [ "species_10506658", "catalyst" ] ], "additional_components": [ "species_29602", "species_109330", "species_113578", "CHEBI:16192", "CHEBI:17172", "CHEBI:28997", "species_83927", "CHEBI:16750", "Q95X21", "WBGene00022201", "species_114632" ] }, "reaction_10506663": { "compartment": "compartment_70101", "id": "reaction_10506663", "reactome": "R-CEL-74249", "name": "(deoxy)guanosine + orthophosphate <=> guanine + (deoxy)ribose 1-phosphate (NP)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29372", "species_500245" ], "products": [ "species_83956", "species_500244" ], "modifiers": [ [ "species_10506638", "catalyst" ] ], "additional_components": [ "CHEBI:17172", "CHEBI:16750", "CHEBI:28542", "species_112016", "U4PSA1", "WBGene00019298" ] }, "reaction_10506665": { "compartment": "compartment_70101", "id": "reaction_10506665", "reactome": "R-CEL-74258", "name": "Xanthine + H2O + O2 => Urate + H2O2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_29368", "species_30064" ], "products": [ "species_30034", "species_29408" ], "modifiers": [ [ "species_10506648", "catalyst" ] ], "additional_components": [ "O17892", "WBGene00010083", "CHEBI:44074", "species_113596" ] }, "reaction_10506651": { "compartment": "compartment_70101", "id": "reaction_10506651", "reactome": "R-CEL-74247", "name": "Hypoxanthine + H2O + O2 => Xanthine + H2O2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113599", "species_29356", "species_29368" ], "products": [ "species_29408", "species_30064" ], "modifiers": [ [ "species_10506648", "catalyst" ] ], "additional_components": [ "O17892", "WBGene00010083", "CHEBI:44074", "species_113596" ] }, "reaction_10544716": { "compartment": "compartment_70101", "id": "reaction_10544716", "reactome": "R-CEL-2509827", "name": "ITPA hydrolyses ITP to IMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_2509836" ], "products": [ "species_111294", "species_29602" ], "modifiers": [ [ "species_10544713", "catalyst" ], [ "species_29926", "catalyst" ] ], "additional_components": [ "Q9GYG4", "WBGene00001823" ] }, "reaction_10544719": { "compartment": "compartment_70101", "id": "reaction_10544719", "reactome": "R-CEL-2509831", "name": "ITPA hydrolyses XTP to XMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2509848", "species_29356" ], "products": [ "species_111294", "species_111584" ], "modifiers": [ [ "species_10544713", "catalyst" ], [ "species_29926", "catalyst" ] ], "additional_components": [ "Q9GYG4", "WBGene00001823" ] }, "reaction_10566331": { "compartment": "compartment_7660", "id": "reaction_10566331", "reactome": "R-CEL-8866601", "name": "SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_8866574" ], "products": [ "species_8866608", "species_8866567" ], "modifiers": [ [ "species_10566328", "catalyst" ], [ "species_29892", "catalyst" ] ], "additional_components": [ "Q09374", "WBGene00022673", "species_216785" ] }, "reaction_10565105": { "compartment": "compartment_17963", "id": "reaction_10565105", "reactome": "R-CEL-8851234", "name": "NTPDase4 hydrolyzes nucleoside triphosphates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2022884", "species_8851233" ], "products": [ "species_8851224", "species_8851226" ], "modifiers": [ [ "species_10565099", "catalyst" ] ], "additional_components": [ "species_110614", "species_29494", "species_29438", "species_30187", "species_110094", "species_158602", "species_29420", "CHEBI:18075", "species_74016", "Q18411", "WBGene00016380", "Q21815", "WBGene00003254" ] }, "reaction_10565122": { "compartment": "compartment_984", "id": "reaction_10565122", "reactome": "R-CEL-8851396", "name": "NTPDase6 hydrolyzes nucleoside diphosphates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_8851462" ], "products": [ "species_109277", "species_8851461" ], "modifiers": [ [ "species_10565119", "catalyst" ] ], "additional_components": [ "CHEBI:17808", "species_158602", "species_29420", "species_110094", "species_109402", "species_29602", "species_109395", "species_113578", "species_114632", "species_74016", "Q9XU84", "WBGene00010697" ] }, "reaction_10565129": { "compartment": "compartment_528865", "id": "reaction_10565129", "reactome": "R-CEL-8851494", "name": "NTPDase7 hydrolyzes nucleoside triphosphates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8851517", "species_8851509" ], "products": [ "species_8851513", "species_8851518" ], "modifiers": [ [ "species_10565126", "catalyst" ] ], "additional_components": [ "species_29494", "species_29438", "species_110614", "species_110094", "species_158602", "species_29420", "Q21815", "WBGene00003254", "species_74016" ] }, "reaction_10565115": { "compartment": "compartment_984", "id": "reaction_10565115", "reactome": "R-CEL-8851356", "name": "NTPDase5 hydrolyzes nucleoside diphosphates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_8936165" ], "products": [ "species_8851369", "species_109277" ], "modifiers": [ [ "species_10565112", "catalyst" ] ], "additional_components": [ "species_113582", "species_158602", "species_29420", "species_110094", "species_109402", "species_109395", "species_113578", "species_76577", "species_114632", "species_74016", "Q9XU84", "WBGene00010697" ] }, "reaction_10565102": { "compartment": "compartment_17963", "id": "reaction_10565102", "reactome": "R-CEL-8851225", "name": "NTPDase4 hydrolyzes nucleoside diphosphates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8851224", "species_2022884" ], "products": [ "species_8851226", "species_8851227" ], "modifiers": [ [ "species_10565099", "catalyst" ] ], "additional_components": [ "species_110094", "species_158602", "species_29420", "CHEBI:18075", "species_113578", "species_109366", "species_109402", "species_109395", "species_74016", "Q18411", "WBGene00016380", "Q21815", "WBGene00003254" ] }, "reaction_10506608": { "compartment": "compartment_70101", "id": "reaction_10506608", "reactome": "R-CEL-74213", "name": "Adenine + PRPP => AMP + PPi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73566", "species_83951" ], "products": [ "species_111294", "species_76577" ], "modifiers": [ [ "species_10506605", "catalyst" ] ], "additional_components": [ "P91455", "WBGene00020557" ] }, "reaction_10542967": { "compartment": "compartment_70101", "id": "reaction_10542967", "reactome": "R-CEL-2161187", "name": "N6-methyl-AMP + H2O => IMP + methylamine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_2161190" ], "products": [ "species_2161177", "species_29602" ], "modifiers": [ [ "species_10542964", "catalyst" ] ], "additional_components": [ "Q8IG39", "WBGene00016632", "species_216785" ] }, "reaction_10506631": { "compartment": "compartment_70101", "id": "reaction_10506631", "reactome": "R-CEL-74241", "name": "(2'-deoxy)adenosine + H2O => (2'-deoxy)inosine + NH4+ (ADA)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_500173" ], "products": [ "species_500172", "species_31633" ], "modifiers": [ [ "species_10506628", "catalyst" ] ], "additional_components": [ "species_83909", "CHEBI:17256", "CHEBI:28997", "species_83927", "WBGene00015551" ] }, "reaction_10527223": { "compartment": "compartment_70101", "id": "reaction_10527223", "reactome": "R-CEL-514604", "name": "GMP + NADPH + H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_113578", "species_29364" ], "products": [ "species_29366", "species_29602", "species_31633" ], "modifiers": [ [ "species_10527220", "catalyst" ] ], "additional_components": [ "O16294", "WBGene00017984" ] }, "reaction_10508120": { "compartment": "compartment_70101", "id": "reaction_10508120", "reactome": "R-CEL-76590", "name": "AMP + H2O => IMP + NH4+ (AMPD)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_76577" ], "products": [ "species_29602", "species_31633" ], "modifiers": [ [ "species_10508117", "catalyst" ] ], "additional_components": [ "A0A2C9C377", "WBGene00016415" ] }, "reaction_10506618": { "compartment": "compartment_70101", "id": "reaction_10506618", "reactome": "R-CEL-74215", "name": "guanine or hypoxanthine + PRPP => GMP or IMP + PPi (HPRT1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73566", "species_500259" ], "products": [ "species_111294", "species_500260" ], "modifiers": [ [ "species_10506615", "catalyst" ] ], "additional_components": [ "species_83956", "species_113599", "species_29602", "species_113578", "Q9NF11", "WBGene00013690", "species_114632" ] }, "reaction_10508442": { "compartment": "compartment_70101", "id": "reaction_10508442", "reactome": "R-CEL-109624", "name": "(2'-deoxy)adenosine + ATP => (d)AMP + ADP (ADK)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_500173", "species_113592" ], "products": [ "species_500088", "species_29370" ], "modifiers": [ [ "species_10508439", "catalyst" ] ], "additional_components": [ "species_83909", "CHEBI:17256", "species_76577", "species_109386", "Q93934", "WBGene00011128", "species_114632" ] }, "reaction_10508640": { "compartment": "compartment_70101", "id": "reaction_10508640", "reactome": "R-CEL-110138", "name": "AK5,7,8,9 phosphorylates (d)NMPs to (d)NDPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6788778", "species_113592" ], "products": [ "species_29370", "species_6788782" ], "modifiers": [ [ "species_10508635", "catalyst" ] ], "additional_components": [ "species_76577", "species_109395", "CHEBI:15918", "species_109386", "species_113582", "CHEBI:28846", "CHEBI:16174", "species_110094", "Q20140", "WBGene00009531" ] }, "reaction_10508896": { "compartment": "compartment_70101", "id": "reaction_10508896", "reactome": "R-CEL-111746", "name": "glutaredoxin (oxidized) + glutathione (reduced) => glutaredoxin (reduced) + glutathione (oxidized)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29450", "species_10508874" ], "products": [ "species_10508871", "species_111745" ], "modifiers": [ [ "species_10508874", "catalyst" ] ], "additional_components": [ "WBGene00021331", "WBGene00021331", "WBGene00021331" ] }, "reaction_10506017": { "compartment": "compartment_70101", "id": "reaction_10506017", "reactome": "R-CEL-73548", "name": "(d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP (CMPK1)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_500009", "species_113592" ], "products": [ "species_29370", "species_500006" ], "modifiers": [ [ "species_10506014", "catalyst" ] ], "additional_components": [ "species_109395", "CHEBI:15918", "species_109402", "species_158602", "CHEBI:28846", "species_110094", "Q20230", "WBGene00009575" ] }, "reaction_10508642": { "compartment": "compartment_70101", "id": "reaction_10508642", "reactome": "R-CEL-110141", "name": "(d)ADP + ADP <=> (d)AMP + ATP (AK1)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29370", "species_500087" ], "products": [ "species_500088", "species_113592" ], "modifiers": [ [ "species_10506620", "catalyst" ] ], "additional_components": [ "species_113582", "CHEBI:16174", "species_76577", "species_109386", "Q20140", "WBGene00009531" ] }, "reaction_10508899": { "compartment": "compartment_70101", "id": "reaction_10508899", "reactome": "R-CEL-111751", "name": "RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8866401", "species_10506160" ], "products": [ "species_10506158", "species_29356", "species_8866399" ], "modifiers": [ [ "species_10508890", "catalyst" ], [ "species_113592", "catalyst" ], [ "species_110644", "inhibitor" ] ], "additional_components": [ "WBGene00015062", "WBGene00015062", "Q03604", "WBGene00004391", "P42170", "WBGene00004392", "species_912516" ] }, "reaction_10563109": { "compartment": "compartment_70101", "id": "reaction_10563109", "reactome": "R-CEL-6806877", "name": "NME1:NME3 heterohexamer, NME2P1 phosphorylate NDPs to NTPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_6806885" ], "products": [ "species_29370", "species_6806881" ], "modifiers": [ [ "species_10563106", "catalyst" ] ], "additional_components": [ "Q93576", "WBGene00009119", "Q7KX00", "WBGene00021692" ] }, "reaction_10526887": { "compartment": "compartment_70101", "id": "reaction_10526887", "reactome": "R-CEL-482619", "name": "(d)NDP + ATP <=> (d)NTP + ADP (NME1,2,3)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_482627" ], "products": [ "species_29370", "species_482625" ], "modifiers": [ [ "species_10526884", "catalyst" ] ], "additional_components": [ "species_158602", "CHEBI:28846", "CHEBI:16174", "species_29420", "CHEBI:28850", "CHEBI:28862", "CHEBI:18075", "species_110094", "species_29892", "species_110644", "species_30185", "species_29494", "species_30187", "species_110614", "species_500739", "species_29438", "Q93576", "WBGene00009119", "Q7KX00", "WBGene00021692" ] }, "reaction_10506152": { "compartment": "compartment_70101", "id": "reaction_10506152", "reactome": "R-CEL-73635", "name": "dUMP or TMP + ATP <=> dUDP or TDP + ADP [DTYMK]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_499997", "species_113592" ], "products": [ "species_29370", "species_499999" ], "modifiers": [ [ "species_10506149", "catalyst" ] ], "additional_components": [ "species_500742", "species_109366", "CHEBI:28850", "CHEBI:18075", "Q22018", "WBGene00011272" ] }, "reaction_10508650": { "compartment": "compartment_70101", "id": "reaction_10508650", "reactome": "R-CEL-110144", "name": "ADP + ADP <=> AMP + ATP [AK2]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29370" ], "products": [ "species_113592", "species_76577" ], "modifiers": [ [ "species_10508647", "catalyst" ] ], "additional_components": [ "WBGene00002879" ] }, "reaction_10508908": { "compartment": "compartment_70101", "id": "reaction_10508908", "reactome": "R-CEL-111804", "name": "RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8866401", "species_10506160" ], "products": [ "species_10506158", "species_29356", "species_8866399" ], "modifiers": [ [ "species_10508905", "catalyst" ], [ "species_113592", "catalyst" ], [ "species_110644", "inhibitor" ] ], "additional_components": [ "WBGene00015062", "WBGene00015062", "Q03604", "WBGene00004391", "P42170", "WBGene00004392", "species_912516" ] }, "reaction_10527086": { "compartment": "compartment_5460", "id": "reaction_10527086", "reactome": "R-CEL-482804", "name": "(d)NDP + ATP <=> (d)NTP + ADP (NME4)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113593", "species_482803" ], "products": [ "species_113581", "species_482807" ], "modifiers": [ [ "species_10527083", "catalyst" ] ], "additional_components": [ "CHEBI:18075", "species_29420", "CHEBI:28850", "CHEBI:28862", "species_158602", "CHEBI:16174", "CHEBI:28846", "species_110094", "species_110614", "species_29438", "species_500739", "species_29892", "species_29494", "species_110644", "species_30185", "species_30187", "Q7KX00", "WBGene00021692", "Q93576", "WBGene00009119" ] }, "reaction_10506180": { "compartment": "compartment_70101", "id": "reaction_10506180", "reactome": "R-CEL-73647", "name": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_29494", "species_29472" ], "products": [ "species_29372", "species_29404", "species_29370", "species_110614" ], "modifiers": [ [ "species_10506177", "catalyst" ] ], "additional_components": [ "G5EC98", "WBGene00012316" ] }, "reaction_10506116": { "compartment": "compartment_70101", "id": "reaction_10506116", "reactome": "R-CEL-73605", "name": "dUMP + N5,N10-methylene tetrahydrofolate => TMP + dihydrofolate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111355", "species_109382" ], "products": [ "species_109366", "species_73604" ], "modifiers": [ [ "species_10506113", "catalyst" ] ], "additional_components": [ "species_114632", "Q9N588", "WBGene00022455" ] }, "reaction_10527109": { "compartment": "compartment_70101", "id": "reaction_10527109", "reactome": "R-CEL-504054", "name": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_29494", "species_29472" ], "products": [ "species_29372", "species_29404", "species_29370", "species_110614" ], "modifiers": [ [ "species_10527106", "catalyst" ] ], "additional_components": [ "G5EC98", "WBGene00012316" ] }, "reaction_10566276": { "compartment": "compartment_70101", "id": "reaction_10566276", "reactome": "R-CEL-8866405", "name": "RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508871", "species_8866401" ], "products": [ "species_29356", "species_10508874", "species_8866399" ], "modifiers": [ [ "species_10508905", "catalyst" ], [ "species_113592", "catalyst" ], [ "species_110644", "inhibitor" ] ], "additional_components": [ "WBGene00021331", "WBGene00021331", "Q03604", "WBGene00004391", "P42170", "WBGene00004392", "species_912516" ] }, "reaction_10558343": { "compartment": "compartment_7660", "id": "reaction_10558343", "reactome": "R-CEL-6788810", "name": "AK6 phosphorylates (d)NMPs to (d)NDPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_6788813" ], "products": [ "species_113582", "species_6788807" ], "modifiers": [ [ "species_10558340", "catalyst" ] ], "additional_components": [ "CHEBI:15918", "species_109395", "species_76577", "species_109386", "species_110094", "CHEBI:16174", "CHEBI:28846", "species_113582", "WBGene00008458" ] }, "reaction_10506190": { "compartment": "compartment_7660", "id": "reaction_10506190", "reactome": "R-CEL-73666", "name": "dUTP + H2O => dUMP + pyrophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_500739" ], "products": [ "species_113541", "species_500742" ], "modifiers": [ [ "species_10506187", "catalyst" ] ], "additional_components": [ "G5EET2", "WBGene00010609" ] }, "reaction_10508631": { "compartment": "compartment_70101", "id": "reaction_10508631", "reactome": "R-CEL-110133", "name": "(d)GDP + ADP <=> (d)GMP + ATP (GUK1)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29370", "species_500077" ], "products": [ "species_113592", "species_500071" ], "modifiers": [ [ "species_10506329", "catalyst" ] ], "additional_components": [ "species_29420", "CHEBI:28862", "species_113578", "CHEBI:16192", "WBGene00020190" ] }, "reaction_10508893": { "compartment": "compartment_70101", "id": "reaction_10508893", "reactome": "R-CEL-111742", "name": "RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508871", "species_8866401" ], "products": [ "species_29356", "species_10508874", "species_8866399" ], "modifiers": [ [ "species_10508890", "catalyst" ], [ "species_113592", "catalyst" ], [ "species_110644", "inhibitor" ] ], "additional_components": [ "WBGene00021331", "WBGene00021331", "Q03604", "WBGene00004391", "P42170", "WBGene00004392", "species_912516" ] }, "reaction_10508638": { "compartment": "compartment_70101", "id": "reaction_10508638", "reactome": "R-CEL-110137", "name": "(d)ADP or (d)CDP + ADP <=> (d)AMP or (d)CMP + ATP", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29370", "species_6788782" ], "products": [ "species_6788778", "species_113592" ], "modifiers": [ [ "species_10508635", "catalyst" ] ], "additional_components": [ "species_113582", "CHEBI:28846", "CHEBI:16174", "species_110094", "species_76577", "species_109395", "CHEBI:15918", "species_109386", "Q20140", "WBGene00009531" ] }, "reaction_10542971": { "compartment": "compartment_70101", "id": "reaction_10542971", "reactome": "R-CEL-2161500", "name": "abacavir [extracellular] => abacavir [cytosol]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2161525" ], "products": [ "species_2161185" ], "modifiers": [ [ "species_10518788", "catalyst" ] ], "additional_components": [ "WBGene00003987" ] }, "reaction_10510416": { "compartment": "compartment_5460", "id": "reaction_10510416", "reactome": "R-CEL-164834", "name": "Enzyme-bound ATP is released", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10510410", "species_163953" ], "products": [ "species_113529", "species_113593", "species_10510406" ], "modifiers": [ [ "species_10510410", "catalyst" ] ], "additional_components": [ "O16314", "WBGene00015460", "Q18803", "WBGene00000210", "Q17763", "WBGene00007385", "Q19126", "WBGene00000207", "Q9BKS0", "WBGene00022336", "Q21732", "WBGene00011015", "O16517", "WBGene00020275", "Q22021", "WBGene00011273", "Q09544", "WBGene00019061", "Q9XXK1", "WBGene00010419", "O16298", "WBGene00017982", "P46561", "WBGene00000229", "Q95XJ0", "WBGene00022089", "Q7JNG1", "WBGene00000230", "species_29358", "O16314", "WBGene00015460", "Q18803", "WBGene00000210", "Q17763", "WBGene00007385", "Q19126", "WBGene00000207", "Q9BKS0", "WBGene00022336", "Q21732", "WBGene00011015", "O16517", "WBGene00020275", "Q22021", "WBGene00011273", "Q09544", "WBGene00019061", "Q9XXK1", "WBGene00010419", "O16298", "WBGene00017982", "P46561", "WBGene00000229", "Q95XJ0", "WBGene00022089", "Q7JNG1", "WBGene00000230", "O16314", "WBGene00015460", "Q18803", "WBGene00000210", "Q17763", "WBGene00007385", "Q19126", "WBGene00000207", "Q9BKS0", "WBGene00022336", "Q21732", "WBGene00011015", "O16517", "WBGene00020275", "Q22021", "WBGene00011273", "Q09544", "WBGene00019061", "Q9XXK1", "WBGene00010419", "O16298", "WBGene00017982", "P46561", "WBGene00000229", "Q95XJ0", "WBGene00022089", "Q7JNG1", "WBGene00000230", "species_29358" ] }, "reaction_10510418": { "compartment": "compartment_5460", "id": "reaction_10510418", "reactome": "R-CEL-164840", "name": "ADP and Pi bind to ATPase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113548", "species_113581", "species_10510406" ], "products": [ "species_10510408" ], "modifiers": [], "additional_components": [ "O16314", "WBGene00015460", "Q18803", "WBGene00000210", "Q17763", "WBGene00007385", "Q19126", "WBGene00000207", "Q9BKS0", "WBGene00022336", "Q21732", "WBGene00011015", "O16517", "WBGene00020275", "Q22021", "WBGene00011273", "Q09544", "WBGene00019061", "Q9XXK1", "WBGene00010419", "O16298", "WBGene00017982", "P46561", "WBGene00000229", "Q95XJ0", "WBGene00022089", "Q7JNG1", "WBGene00000230", "O16314", "WBGene00015460", "Q18803", "WBGene00000210", "Q17763", "WBGene00007385", "Q19126", "WBGene00000207", "Q9BKS0", "WBGene00022336", "Q21732", "WBGene00011015", "O16517", "WBGene00020275", "Q22021", "WBGene00011273", "Q09544", "WBGene00019061", "Q9XXK1", "WBGene00010419", "O16298", "WBGene00017982", "P46561", "WBGene00000229", "Q95XJ0", "WBGene00022089", "Q7JNG1", "WBGene00000230", "species_113582", "species_29372" ] }, "reaction_10510413": { "compartment": "compartment_5460", "id": "reaction_10510413", "reactome": "R-CEL-164832", "name": "ATPase synthesizes ATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10510408" ], "products": [ "species_10510410", "species_113521" ], "modifiers": [ [ "species_10510408", "catalyst" ] ], "additional_components": [ "O16314", "WBGene00015460", "Q18803", "WBGene00000210", "Q17763", "WBGene00007385", "Q19126", "WBGene00000207", "Q9BKS0", "WBGene00022336", "Q21732", "WBGene00011015", "O16517", "WBGene00020275", "Q22021", "WBGene00011273", "Q09544", "WBGene00019061", "Q9XXK1", "WBGene00010419", "O16298", "WBGene00017982", "P46561", "WBGene00000229", "Q95XJ0", "WBGene00022089", "Q7JNG1", "WBGene00000230", "species_113582", "species_29372", "O16314", "WBGene00015460", "Q18803", "WBGene00000210", "Q17763", "WBGene00007385", "Q19126", "WBGene00000207", "Q9BKS0", "WBGene00022336", "Q21732", "WBGene00011015", "O16517", "WBGene00020275", "Q22021", "WBGene00011273", "Q09544", "WBGene00019061", "Q9XXK1", "WBGene00010419", "O16298", "WBGene00017982", "P46561", "WBGene00000229", "Q95XJ0", "WBGene00022089", "Q7JNG1", "WBGene00000230", "species_29358", "O16314", "WBGene00015460", "Q18803", "WBGene00000210", "Q17763", "WBGene00007385", "Q19126", "WBGene00000207", "Q9BKS0", "WBGene00022336", "Q21732", "WBGene00011015", "O16517", "WBGene00020275", "Q22021", "WBGene00011273", "Q09544", "WBGene00019061", "Q9XXK1", "WBGene00010419", "O16298", "WBGene00017982", "P46561", "WBGene00000229", "Q95XJ0", "WBGene00022089", "Q7JNG1", "WBGene00000230", "species_113582", "species_29372" ] }, "reaction_10546133": { "compartment": "compartment_5460", "id": "reaction_10546133", "reactome": "R-CEL-2995334", "name": "COX15 transforms heme O to heme A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2995328" ], "products": [ "species_2995348" ], "modifiers": [ [ "species_10546130", "catalyst" ] ], "additional_components": [ "WBGene00011526" ] }, "reaction_10529229": { "compartment": "compartment_876", "id": "reaction_10529229", "reactome": "R-CEL-917979", "name": "ABCG2 tetramer transports heme from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_71185" ], "products": [ "species_29372", "species_917877", "species_29370" ], "modifiers": [ [ "species_10529226", "catalyst" ] ], "additional_components": [ "D7SFK1", "WBGene00006522" ] }, "reaction_10546125": { "compartment": "compartment_5460", "id": "reaction_10546125", "reactome": "R-CEL-2995330", "name": "COX10 transforms heme to heme O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189444", "species_2162257", "species_113521" ], "products": [ "species_2995328", "species_159450" ], "modifiers": [ [ "species_10546122", "catalyst" ] ], "additional_components": [ "WBGene00012895" ] }, "reaction_10512862": { "compartment": "compartment_5460", "id": "reaction_10512862", "reactome": "R-CEL-189465", "name": "FECH binds Fe2+ to PRIN9 to form heme", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189487", "species_113531" ], "products": [ "species_113529", "species_189444" ], "modifiers": [ [ "species_10512859", "catalyst" ], [ "species_391232", "inhibitor" ] ], "additional_components": [ "G5EBW5", "WBGene00010645" ] }, "reaction_10572969": { "compartment": "compartment_70101", "id": "reaction_10572969", "reactome": "R-CEL-9661397", "name": "SLCO1B1 transports BIL from extracellular region (blood) to cytosol (hepatocyte)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9661418" ], "products": [ "species_189386" ], "modifiers": [ [ "species_10528178", "catalyst" ] ], "additional_components": [ "Q95ZT3", "WBGene00018568", "O62421", "WBGene00018568", "Q20538", "WBGene00018568", "Q93550", "WBGene00018568" ] }, "reaction_10573000": { "compartment": "compartment_70101", "id": "reaction_10573000", "reactome": "R-CEL-9661799", "name": "SLCO1B3 transports BIL from extracellular region (blood) to cytosol (hepatocyte)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9661418" ], "products": [ "species_189386" ], "modifiers": [ [ "species_10572997", "catalyst" ] ], "additional_components": [ "Q93550", "WBGene00018568", "Q95ZT3", "WBGene00018568", "O62421", "WBGene00018568", "Q20538", "WBGene00018568" ] }, "reaction_10572987": { "compartment": "compartment_876", "id": "reaction_10572987", "reactome": "R-CEL-9661723", "name": "SLCO2B1-3 transports BIL from extracellular region (blood) to cytosol (hepatocyte)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9661418" ], "products": [ "species_189386" ], "modifiers": [ [ "species_10572984", "catalyst" ] ], "additional_components": [ "O62421", "WBGene00018568", "Q20538", "WBGene00018568", "Q93550", "WBGene00018568", "Q95ZT3", "WBGene00018568" ] }, "reaction_10573004": { "compartment": "compartment_70101", "id": "reaction_10573004", "reactome": "R-CEL-9663492", "name": "BIL dissociates from GSTA1, FABP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10573002" ], "products": [ "species_189386", "species_10551347" ], "modifiers": [], "additional_components": [ "O02324", "WBGene00002260", "O01812", "WBGene00002258", "O01814", "WBGene00002257", "O02323", "WBGene00002259", "species_189386", "O02324", "WBGene00002260", "O01812", "WBGene00002258", "O01814", "WBGene00002257", "O02323", "WBGene00002259" ] }, "reaction_10573006": { "compartment": "compartment_70101", "id": "reaction_10573006", "reactome": "R-CEL-9663511", "name": "BIL binds GSTA1, FABP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189386", "species_10551347" ], "products": [ "species_10573002" ], "modifiers": [], "additional_components": [ "O02324", "WBGene00002260", "O01812", "WBGene00002258", "O01814", "WBGene00002257", "O02323", "WBGene00002259", "O02324", "WBGene00002260", "O01812", "WBGene00002258", "O01814", "WBGene00002257", "O02323", "WBGene00002259", "species_189386" ] }, "reaction_10572974": { "compartment": "compartment_70101", "id": "reaction_10572974", "reactome": "R-CEL-9661417", "name": "ABCG2 tetramer transports BMG,BDG from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_5679042" ], "products": [ "species_29372", "species_5679034", "species_29370" ], "modifiers": [ [ "species_10529226", "catalyst" ] ], "additional_components": [ "CHEBI:18392", "CHEBI:16427", "CHEBI:16427", "CHEBI:18392", "D7SFK1", "WBGene00006522" ] }, "reaction_10535157": { "compartment": "compartment_70101", "id": "reaction_10535157", "reactome": "R-CEL-1497810", "name": "Uncoupled eNOS favours the formation of superoxide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_29364" ], "products": [ "species_1222424", "species_29366" ], "modifiers": [ [ "species_10535152", "catalyst" ] ], "additional_components": [ "Q9XTG7", "WBGene00000103", "G4S4W1", "WBGene00016980", "Q17941", "WBGene00000102", "species_74016", "Q11083", "WBGene00020378", "P04630", "WBGene00000285", "G5EF37", "WBGene00003934", "A0A2C9C3L3", "WBGene00020378", "Q18136", "WBGene00006861", "Q09665", "WBGene00006583", "O02159", "WBGene00020378", "G5EDZ8", "WBGene00000288", "Q94288", "WBGene00000287", "Q09980", "WBGene00017394", "O16305", "WBGene00000552", "G5EEG0", "WBGene00000286", "Q18688", "WBGene00000915", "species_1497857", "species_71185", "species_216785", "species_73524", "species_113596", "species_29870" ] }, "reaction_10551508": { "compartment": "compartment_70101", "id": "reaction_10551508", "reactome": "R-CEL-5340226", "name": "CYGB dioxygenates NO", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_202124", "species_10551503", "species_70106", "species_29364" ], "products": [ "species_10551501", "species_432031", "species_29366" ], "modifiers": [ [ "species_10551503", "catalyst" ] ], "additional_components": [ "species_113534", "species_71185", "O17824", "WBGene00008996", "species_71185", "O17824", "WBGene00008996", "species_113534", "species_71185", "O17824", "WBGene00008996" ] }, "reaction_10567554": { "compartment": "compartment_70101", "id": "reaction_10567554", "reactome": "R-CEL-8876789", "name": "CARNMT1 methylates CARN to Anserine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6786250", "species_71284" ], "products": [ "species_71285", "species_8876775" ], "modifiers": [ [ "species_10567551", "catalyst" ] ], "additional_components": [ "WBGene00013015" ] }, "reaction_10503510": { "compartment": "compartment_70101", "id": "reaction_10503510", "reactome": "R-CEL-70903", "name": "urocanate + H2O => 4-imidazolone-5-propionate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_30721" ], "products": [ "species_34979" ], "modifiers": [ [ "species_10503507", "catalyst" ] ], "additional_components": [ "species_29360", "Q9NAE2", "WBGene00013103" ] }, "reaction_10503500": { "compartment": "compartment_70101", "id": "reaction_10503500", "reactome": "R-CEL-70899", "name": "histidine => urocanate + NH4+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29612" ], "products": [ "species_31633", "species_30721" ], "modifiers": [ [ "species_10503497", "catalyst" ] ], "additional_components": [ "WBGene00009813" ] }, "reaction_10503518": { "compartment": "compartment_70101", "id": "reaction_10503518", "reactome": "R-CEL-70906", "name": "4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_34979" ], "products": [ "species_30158", "species_70106" ], "modifiers": [ [ "species_10503515", "catalyst" ] ], "additional_components": [ "WBGene00020436" ] }, "reaction_10571277": { "compartment": "compartment_70101", "id": "reaction_10571277", "reactome": "R-CEL-9014641", "name": "HRSP12 deaminates 2AA to 2OBUTA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9014643" ], "products": [ "species_29382", "species_936714" ], "modifiers": [ [ "species_10571274", "catalyst" ] ], "additional_components": [ "WBGene00016011" ] }, "reaction_10503714": { "compartment": "compartment_5460", "id": "reaction_10503714", "reactome": "R-CEL-71037", "name": "alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_113526", "species_70951" ], "products": [ "species_70955", "species_29362", "species_29376" ], "modifiers": [ [ "species_10503711", "catalyst" ] ], "additional_components": [ "O61199", "WBGene00020679", "species_8878387", "CHEBI:17460", "O45148", "WBGene00020950", "O17953", "WBGene00010794", "species_113596" ] }, "reaction_10503541": { "compartment": "compartment_5460", "id": "reaction_10503541", "reactome": "R-CEL-70941", "name": "alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113526", "species_113556", "species_113521" ], "products": [ "species_113529", "species_508531", "species_29362" ], "modifiers": [ [ "species_10503538", "catalyst" ] ], "additional_components": [ "P46562", "WBGene00000115" ] }, "reaction_10503528": { "compartment": "compartment_5460", "id": "reaction_10503528", "reactome": "R-CEL-70938", "name": "lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113594", "species_113529", "species_29444", "species_113600" ], "products": [ "species_113563", "species_113521", "species_30176" ], "modifiers": [ [ "species_10503525", "catalyst" ] ], "additional_components": [ "U4PFH6", "WBGene00019819" ] }, "reaction_10503531": { "compartment": "compartment_5460", "id": "reaction_10503531", "reactome": "R-CEL-70940", "name": "saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113526", "species_113521", "species_30176" ], "products": [ "species_113529", "species_113556", "species_29362", "species_113552" ], "modifiers": [ [ "species_10503525", "catalyst" ] ], "additional_components": [ "U4PFH6", "WBGene00019819" ] }, "reaction_10518299": { "compartment": "compartment_5460", "id": "reaction_10518299", "reactome": "R-CEL-372480", "name": "2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113594", "species_113577" ], "products": [ "species_29406", "species_70951" ], "modifiers": [ [ "species_10518296", "catalyst" ] ], "additional_components": [ "WBGene00011226" ] }, "reaction_10503724": { "compartment": "compartment_5460", "id": "reaction_10503724", "reactome": "R-CEL-71046", "name": "glutaryl-CoA + FAD => crotonyl-CoA + FADH2 + CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113596", "species_70955" ], "products": [ "species_71045", "species_31649", "species_29376" ], "modifiers": [ [ "species_10503721", "catalyst" ] ], "additional_components": [ "Q20772", "WBGene00010052", "species_113596" ] }, "reaction_10558014": { "compartment": "compartment_17951", "id": "reaction_10558014", "reactome": "R-CEL-6783880", "name": "PIPOX oxidises PPCA to P6C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113535", "species_5693325" ], "products": [ "species_113575", "species_6783877" ], "modifiers": [ [ "species_10558011", "catalyst" ] ], "additional_components": [ "WBGene00015783" ] }, "reaction_10570157": { "compartment": "compartment_70101", "id": "reaction_10570157", "reactome": "R-CEL-8959510", "name": "SEPHS2 phosphorylates H2Se to form SELP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5357660", "species_29356", "species_113592" ], "products": [ "species_29372", "species_70106", "species_8959518", "species_76577" ], "modifiers": [ [ "species_10570154", "catalyst" ] ], "additional_components": [ "WBGene00012867" ] }, "reaction_10551250": { "compartment": "compartment_70101", "id": "reaction_10551250", "reactome": "R-CEL-5263616", "name": "MeSeO2H is reduced to MeSeOH by TXNRD1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5357694", "species_70106", "species_29364" ], "products": [ "species_5357663", "species_29356", "species_29366" ], "modifiers": [ [ "species_10506167", "catalyst" ] ], "additional_components": [ "Q17745", "WBGene00015553", "species_113596" ] }, "reaction_10551247": { "compartment": "compartment_70101", "id": "reaction_10551247", "reactome": "R-CEL-5263614", "name": "MeSeOH is reduced to MeSeH by TXNRD1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5357663", "species_70106", "species_29364" ], "products": [ "species_29356", "species_29366", "species_5357669" ], "modifiers": [ [ "species_10506167", "catalyst" ] ], "additional_components": [ "Q17745", "WBGene00015553", "species_113596" ] }, "reaction_10518289": { "compartment": "compartment_70101", "id": "reaction_10518289", "reactome": "R-CEL-372448", "name": "SLC25A12,13 exchange cytosolic L-Glu for mitochondrial matrix L-Asp", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29404", "species_113553" ], "products": [ "species_29448", "species_113552" ], "modifiers": [ [ "species_10518286", "catalyst" ] ], "additional_components": [ "Q21153", "WBGene00019326" ] }, "reaction_10503201": { "compartment": "compartment_5460", "id": "reaction_10503201", "reactome": "R-CEL-70596", "name": "GOT2 dimer deaminates L-Asp", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113594", "species_113553" ], "products": [ "species_113587", "species_113552" ], "modifiers": [ [ "species_10503198", "catalyst" ] ], "additional_components": [ "Q17994", "WBGene00015778" ] }, "reaction_10557141": { "compartment": "compartment_876", "id": "reaction_10557141", "reactome": "R-CEL-5693783", "name": "NAALADases hydrolyse NAAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5693762" ], "products": [ "species_29404", "species_5693772" ], "modifiers": [ [ "species_10557138", "catalyst" ] ], "additional_components": [ "P91406", "WBGene00020082", "Q93332", "WBGene00007954" ] }, "reaction_10503190": { "compartment": "compartment_70101", "id": "reaction_10503190", "reactome": "R-CEL-70592", "name": "PXLP-K259-GOT1 dimer deaminates L-Asp", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29406", "species_29448" ], "products": [ "species_29404", "species_76213" ], "modifiers": [ [ "species_10503175", "catalyst" ] ], "additional_components": [ "Q22067", "WBGene00020146" ] }, "reaction_10559320": { "compartment": "compartment_70101", "id": "reaction_10559320", "reactome": "R-CEL-6797627", "name": "ASPG hydrolyses L-Asn to L-Asp", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_29642" ], "products": [ "species_29448", "species_29382" ], "modifiers": [ [ "species_10559317", "catalyst" ] ], "additional_components": [ "WBGene00007756" ] }, "reaction_10503178": { "compartment": "compartment_70101", "id": "reaction_10503178", "reactome": "R-CEL-70581", "name": "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29404", "species_76213" ], "products": [ "species_29406", "species_29448" ], "modifiers": [ [ "species_10503175", "catalyst" ] ], "additional_components": [ "Q22067", "WBGene00020146" ] }, "reaction_10503296": { "compartment": "compartment_5460", "id": "reaction_10503296", "reactome": "R-CEL-70666", "name": "glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_31339", "species_113552" ], "products": [ "species_113594", "species_113585" ], "modifiers": [ [ "species_10503281", "catalyst" ] ], "additional_components": [ "Q18040", "WBGene00015814" ] }, "reaction_10503265": { "compartment": "compartment_5460", "id": "reaction_10503265", "reactome": "R-CEL-70613", "name": "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT2]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113587", "species_113552" ], "products": [ "species_113594", "species_113553" ], "modifiers": [ [ "species_10503198", "catalyst" ] ], "additional_components": [ "Q17994", "WBGene00015778" ] }, "reaction_10503203": { "compartment": "compartment_5460", "id": "reaction_10503203", "reactome": "R-CEL-70600", "name": "glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ [GLUD1]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113552", "species_113521", "species_517495" ], "products": [ "species_517496", "species_113594", "species_113529", "species_113561" ], "modifiers": [ [ "species_10503185", "catalyst" ], [ "species_113581", "catalyst" ], [ "species_113573", "inhibitor" ] ], "additional_components": [ "species_29360", "species_29366", "species_29364", "species_73473", "Q23621", "WBGene00014095" ] }, "reaction_10503188": { "compartment": "compartment_5460", "id": "reaction_10503188", "reactome": "R-CEL-70589", "name": "alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ [GLUD1]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_517496", "species_113594", "species_113529", "species_113561" ], "products": [ "species_113552", "species_113521", "species_517495" ], "modifiers": [ [ "species_10503185", "catalyst" ], [ "species_113581", "catalyst" ], [ "species_113573", "inhibitor" ] ], "additional_components": [ "species_29364", "species_73473", "species_29360", "species_29366", "Q23621", "WBGene00014095" ] }, "reaction_10558039": { "compartment": "compartment_70101", "id": "reaction_10558039", "reactome": "R-CEL-6783955", "name": "PYCRL decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_35305", "species_29364" ], "products": [ "species_29366", "species_113538" ], "modifiers": [ [ "species_10558036", "catalyst" ] ], "additional_components": [ "Q21544", "WBGene00010924", "Q20848", "WBGene00018904" ] }, "reaction_10527197": { "compartment": "compartment_5460", "id": "reaction_10527197", "reactome": "R-CEL-508040", "name": "glutamate + ATP + NADPH + H+ => L-glutamate gamma-semialdehyde + NADP+ + ADP + orthophosphate [P5CS]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113529", "species_113593", "species_113600", "species_113552" ], "products": [ "species_113548", "species_113581", "species_31339", "species_113563" ], "modifiers": [ [ "species_10527194", "catalyst" ] ], "additional_components": [ "P54889", "WBGene00011938" ] }, "reaction_10558028": { "compartment": "compartment_5460", "id": "reaction_10558028", "reactome": "R-CEL-6783939", "name": "PYCR2 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113529", "species_113590", "species_29362" ], "products": [ "species_113526", "species_379717" ], "modifiers": [ [ "species_10558025", "catalyst" ] ], "additional_components": [ "Q20848", "WBGene00018904", "Q21544", "WBGene00010924" ] }, "reaction_10503294": { "compartment": "compartment_5460", "id": "reaction_10503294", "reactome": "R-CEL-70664", "name": "PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113529", "species_113590", "species_29362" ], "products": [ "species_113526", "species_379717" ], "modifiers": [ [ "species_10503291", "catalyst" ] ], "additional_components": [ "Q21544", "WBGene00010924" ] }, "reaction_10528415": { "compartment": "compartment_70101", "id": "reaction_10528415", "reactome": "R-CEL-893616", "name": "glutamine + pyruvate => 2-oxoglutaramate + alanine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29398", "species_29472" ], "products": [ "species_29432", "species_893598" ], "modifiers": [ [ "species_10528406", "catalyst" ] ], "additional_components": [ "Q9XX97", "WBGene00009232", "Q8MP09", "WBGene00010984" ] }, "reaction_10516466": { "compartment": "compartment_70101", "id": "reaction_10516466", "reactome": "R-CEL-209924", "name": "Dopa is decarboxylated to dopamine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_209849" ], "products": [ "species_113528", "species_159362" ], "modifiers": [ [ "species_10516426", "catalyst" ] ], "additional_components": [ "O45137", "WBGene00000239" ] }, "reaction_10516446": { "compartment": "compartment_70101", "id": "reaction_10516446", "reactome": "R-CEL-209903", "name": "Noradrenaline is converted to adrenaline", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_209789", "species_71284" ], "products": [ "species_70106", "species_71285", "species_209794" ], "modifiers": [ [ "species_10516443", "catalyst" ] ], "additional_components": [ "Q20308", "WBGene00018340", "Q22279", "WBGene00011573", "P34254", "WBGene00015124" ] }, "reaction_10516399": { "compartment": "compartment_70101", "id": "reaction_10516399", "reactome": "R-CEL-209823", "name": "Tyrosine is hydroxylated to dopa", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29870", "species_29368", "species_29506" ], "products": [ "species_209849", "species_71112" ], "modifiers": [ [ "species_10516396", "catalyst" ] ], "additional_components": [ "species_113531", "P90986", "WBGene00000296" ] }, "reaction_10516464": { "compartment": "compartment_984", "id": "reaction_10516464", "reactome": "R-CEL-209921", "name": "Monoiodinated tyrosine can be deiodinated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351627", "species_351639" ], "products": [ "species_352030", "species_351628", "species_209818" ], "modifiers": [ [ "species_10516461", "catalyst" ] ], "additional_components": [ "species_73524", "P34273", "WBGene00015334" ] }, "reaction_10516468": { "compartment": "compartment_984", "id": "reaction_10516468", "reactome": "R-CEL-209925", "name": "DIT and MIT combine to form triiodothyronine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352329", "species_351639" ], "products": [ "species_352331", "species_352036" ], "modifiers": [ [ "species_10516386", "catalyst" ] ], "additional_components": [ "Q23490", "WBGene00022743", "P91060", "WBGene00015841", "Q1ENI8", "WBGene00004256", "G5EG78", "WBGene00004257", "Q20616", "WBGene00009897", "H2KZ53", "WBGene00017968" ] }, "reaction_10557028": { "compartment": "compartment_876", "id": "reaction_10557028", "reactome": "R-CEL-5693681", "name": "DUOX1,2 reduce O2 to H2O2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_351627", "species_352327" ], "products": [ "species_351628", "species_351629" ], "modifiers": [ [ "species_10557025", "catalyst" ] ], "additional_components": [ "O01795", "WBGene00018771", "O61213", "WBGene00000253" ] }, "reaction_10516389": { "compartment": "compartment_984", "id": "reaction_10516389", "reactome": "R-CEL-209815", "name": "Tyrosine is monoiodinated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351630", "species_352030" ], "products": [ "species_622410", "species_351639" ], "modifiers": [ [ "species_10516386", "catalyst" ] ], "additional_components": [ "Q23490", "WBGene00022743", "P91060", "WBGene00015841", "Q1ENI8", "WBGene00004256", "G5EG78", "WBGene00004257", "Q20616", "WBGene00009897", "H2KZ53", "WBGene00017968" ] }, "reaction_10516454": { "compartment": "compartment_876", "id": "reaction_10516454", "reactome": "R-CEL-209910", "name": "Iodide is taken up by thyroid epithelial cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_209818", "species_74113" ], "products": [ "species_209785", "species_83910" ], "modifiers": [ [ "species_10516451", "catalyst" ] ], "additional_components": [ "WBGene00018716" ] }, "reaction_10516470": { "compartment": "compartment_984", "id": "reaction_10516470", "reactome": "R-CEL-209960", "name": "Diiodinated tyrosine can be deiodinated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351627", "species_352329" ], "products": [ "species_352030", "species_351628", "species_209818" ], "modifiers": [ [ "species_10516461", "catalyst" ] ], "additional_components": [ "species_73524", "P34273", "WBGene00015334" ] }, "reaction_10516472": { "compartment": "compartment_984", "id": "reaction_10516472", "reactome": "R-CEL-209973", "name": "Tyrosine is diiodinated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_351627", "species_352030", "species_209818", "species_351629" ], "products": [ "species_109276", "species_352329", "species_351628" ], "modifiers": [ [ "species_10516386", "catalyst" ] ], "additional_components": [ "Q23490", "WBGene00022743", "P91060", "WBGene00015841", "Q1ENI8", "WBGene00004256", "G5EG78", "WBGene00004257", "Q20616", "WBGene00009897", "H2KZ53", "WBGene00017968" ] }, "reaction_10517997": { "compartment": "compartment_984", "id": "reaction_10517997", "reactome": "R-CEL-350901", "name": "Iodide is organified", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_351627", "species_209818", "species_351629" ], "products": [ "species_109276", "species_351630", "species_351628" ], "modifiers": [ [ "species_10516386", "catalyst" ] ], "additional_components": [ "Q23490", "WBGene00022743", "P91060", "WBGene00015841", "Q1ENI8", "WBGene00004256", "G5EG78", "WBGene00004257", "Q20616", "WBGene00009897", "H2KZ53", "WBGene00017968" ] }, "reaction_10516413": { "compartment": "compartment_984", "id": "reaction_10516413", "reactome": "R-CEL-209840", "name": "Two DITs combine to form thyroxine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352329" ], "products": [ "species_352326", "species_352036" ], "modifiers": [ [ "species_10516386", "catalyst" ] ], "additional_components": [ "Q23490", "WBGene00022743", "P91060", "WBGene00015841", "Q1ENI8", "WBGene00004256", "G5EG78", "WBGene00004257", "Q20616", "WBGene00009897", "H2KZ53", "WBGene00017968" ] }, "reaction_10567841": { "compartment": "compartment_5668575", "id": "reaction_10567841", "reactome": "R-CEL-8878581", "name": "TYRP1 oxidises DHICA to IQCA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5662670", "species_5668566" ], "products": [ "species_8878586", "species_5668574" ], "modifiers": [ [ "species_10567838", "catalyst" ] ], "additional_components": [ "O01497", "WBGene00016419", "O76708", "WBGene00021553", "P34269", "WBGene00015332", "Q19673", "WBGene00009001", "Q95XC6", "WBGene00022231", "Q9XUS8", "WBGene00010661" ] }, "reaction_10554582": { "compartment": "compartment_5668575", "id": "reaction_10554582", "reactome": "R-CEL-5662662", "name": "Tyrosinase oxidises tyrosine to dopaquinone", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5668573", "species_5668567" ], "products": [ "species_5668577", "species_5662695" ], "modifiers": [ [ "species_10554579", "catalyst" ] ], "additional_components": [ "P34269", "WBGene00015332", "species_209799" ] }, "reaction_10554584": { "compartment": "compartment_5668572", "id": "reaction_10554584", "reactome": "R-CEL-5662692", "name": "Dopa is oxidized to dopaquinone by TYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5668568", "species_5668566" ], "products": [ "species_5668574", "species_5662695" ], "modifiers": [ [ "species_10554579", "catalyst" ] ], "additional_components": [ "P34269", "WBGene00015332", "species_209799" ] }, "reaction_10554586": { "compartment": "compartment_5668572", "id": "reaction_10554586", "reactome": "R-CEL-5663050", "name": "DHI and DHICA polymerise forming eumelanin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5662708", "species_5662695" ], "products": [ "species_5668568", "species_5662678" ], "modifiers": [ [ "species_10554579", "catalyst" ] ], "additional_components": [ "species_5662670", "CHEBI:27404", "species_5662670", "CHEBI:27404", "P34269", "WBGene00015332", "species_209799" ] }, "reaction_10554575": { "compartment": "compartment_5668572", "id": "reaction_10554575", "reactome": "R-CEL-5662660", "name": "Dopachrome is transformed to DHICA by DCT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5662665" ], "products": [ "species_5662670" ], "modifiers": [ [ "species_10554572", "catalyst" ] ], "additional_components": [ "Q95XC6", "WBGene00022231", "O76708", "WBGene00021553", "P34269", "WBGene00015332", "Q9XUS8", "WBGene00010661", "O01497", "WBGene00016419", "Q19673", "WBGene00009001", "species_216785" ] }, "reaction_10559330": { "compartment": "compartment_5460", "id": "reaction_10559330", "reactome": "R-CEL-6797653", "name": "DMGDH:FAD oxidatively demethylates DMGLY to SARC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6797923", "species_113521" ], "products": [ "species_6797917", "species_6797920" ], "modifiers": [ [ "species_10559327", "catalyst" ] ], "additional_components": [ "A0A486WWC6", "WBGene00021355", "species_113596" ] }, "reaction_10559333": { "compartment": "compartment_5460", "id": "reaction_10559333", "reactome": "R-CEL-6797955", "name": "ALDH7A1 oxidises BETALD to BET", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113526", "species_6798194", "species_113521" ], "products": [ "species_6798202", "species_29362" ], "modifiers": [ [ "species_10503536", "catalyst" ] ], "additional_components": [ "WBGene00000115" ] }, "reaction_10559341": { "compartment": "compartment_5460", "id": "reaction_10559341", "reactome": "R-CEL-6797961", "name": "CHDH oxidises Cho to BETALD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113596", "species_6798162" ], "products": [ "species_6798194", "species_31649" ], "modifiers": [ [ "species_10559338", "catalyst" ] ], "additional_components": [ "WBGene00007917" ] }, "reaction_10569987": { "compartment": "compartment_5460", "id": "reaction_10569987", "reactome": "R-CEL-8955817", "name": "PRODH2 oxidises HPRO to 1PYR-5COOH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113597", "species_6784215" ], "products": [ "species_113590", "species_164934", "species_113521" ], "modifiers": [ [ "species_10558041", "catalyst" ] ], "additional_components": [ "WBGene00007197" ] }, "reaction_10503304": { "compartment": "compartment_5460", "id": "reaction_10503304", "reactome": "R-CEL-70670", "name": "PRODH oxidises L-Pro to 1PYR-5COOH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113597", "species_379717" ], "products": [ "species_113529", "species_113590", "species_164934" ], "modifiers": [ [ "species_10503301", "catalyst" ] ], "additional_components": [ "WBGene00007197" ] }, "reaction_10520736": { "compartment": "compartment_17951", "id": "reaction_10520736", "reactome": "R-CEL-389862", "name": "Conversion of glyoxylate to oxalate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113535", "species_141343", "species_389678" ], "products": [ "species_389819", "species_113575" ], "modifiers": [ [ "species_10520730", "catalyst" ] ], "additional_components": [ "B1GRK5", "WBGene00018286", "species_73524" ] }, "reaction_10559137": { "compartment": "compartment_5460", "id": "reaction_10559137", "reactome": "R-CEL-6793591", "name": "LIAS:2(4Fe-4S) transforms octanoyl-K107-GCSH to lipoyl-K107-GCSH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6793610", "species_2162265", "species_10559127" ], "products": [ "species_379705", "species_10557165", "species_6793613" ], "modifiers": [ [ "species_10559134", "catalyst" ] ], "additional_components": [ "WBGene00009918", "WBGene00009918", "CHEBI:49883", "Q21452", "WBGene00010809" ] }, "reaction_10558048": { "compartment": "compartment_5460", "id": "reaction_10558048", "reactome": "R-CEL-6784224", "name": "PRODH2:FAD dimer dehydrogenates HPRO to 1-pyrroline-3-hydroxy-5-carboxylate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6784215" ], "products": [ "species_6784241" ], "modifiers": [ [ "species_10558045", "catalyst" ] ], "additional_components": [ "O45228", "WBGene00007197", "species_113596" ] }, "reaction_10520721": { "compartment": "compartment_17951", "id": "reaction_10520721", "reactome": "R-CEL-389821", "name": "glycine + O2 => glyoxylate + H2O2 + NH4+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113535", "species_141343", "species_193446" ], "products": [ "species_389678", "species_389843", "species_113575" ], "modifiers": [ [ "species_10520718", "catalyst" ] ], "additional_components": [ "species_113596", "Q19564", "WBGene00017565", "Q95XG9", "WBGene00022076", "O01739", "WBGene00017648", "O45307", "WBGene00008127" ] }, "reaction_10559104": { "compartment": "compartment_5460", "id": "reaction_10559104", "reactome": "R-CEL-6792572", "name": "LIPT1 transfers lipoyl group from lipoyl-GCSH to DHs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10557165", "species_10559088" ], "products": [ "species_10557167", "species_10559096" ], "modifiers": [ [ "species_10559101", "catalyst" ] ], "additional_components": [ "WBGene00009918", "CHEBI:17460", "O45148", "WBGene00020950", "O61199", "WBGene00020679", "species_8878387", "O17953", "WBGene00010794", "species_113596", "Q93619", "WBGene00006518", "O45924", "WBGene00012713", "Q23571", "WBGene00014054", "P52899", "WBGene00011510", "O44451", "WBGene00015413", "Q19749", "WBGene00009082", "Q23629", "WBGene00014098", "WBGene00009918", "Q23571", "WBGene00014054", "Q93619", "WBGene00006518", "species_8878387", "O45924", "WBGene00012713", "O17953", "WBGene00010794", "species_113596", "Q23629", "WBGene00014098", "O61199", "WBGene00020679", "CHEBI:17460", "O45148", "WBGene00020950", "P52899", "WBGene00011510", "O44451", "WBGene00015413", "Q19749", "WBGene00009082", "WBGene00001590" ] }, "reaction_10558051": { "compartment": "compartment_5460", "id": "reaction_10558051", "reactome": "R-CEL-6784393", "name": "PXLP-K279-GOT2 dimer transaminates 4-OH-L-glutamate to 4-hydroxy-2-oxoglutarate (HOG)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6784236", "species_113587" ], "products": [ "species_6784229", "species_113553" ], "modifiers": [ [ "species_10503198", "catalyst" ] ], "additional_components": [ "Q17994", "WBGene00015778" ] }, "reaction_10520662": { "compartment": "compartment_17951", "id": "reaction_10520662", "reactome": "R-CEL-389684", "name": "glyoxylate + alanine => glycine + pyruvate [peroxisome]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_389678", "species_389664" ], "products": [ "species_389680", "species_193446" ], "modifiers": [ [ "species_10520659", "catalyst" ] ], "additional_components": [ "Q94055", "WBGene00011767" ] }, "reaction_10563702": { "compartment": "compartment_17951", "id": "reaction_10563702", "reactome": "R-CEL-6810076", "name": "DDO oxidizes D-Asp to OA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113535", "species_141343", "species_6810061" ], "products": [ "species_113575", "species_389843", "species_6810070" ], "modifiers": [ [ "species_10563699", "catalyst" ] ], "additional_components": [ "Q95XG9", "WBGene00022076", "species_113596" ] }, "reaction_10528441": { "compartment": "compartment_5460", "id": "reaction_10528441", "reactome": "R-CEL-904864", "name": "Mitochondrial AGXT2 tetramer transaminates glyoxylate and alanine to glycine and pyruvate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_904849", "species_379697" ], "products": [ "species_159549", "species_113557" ], "modifiers": [ [ "species_10528438", "catalyst" ] ], "additional_components": [ "O02158", "WBGene00020382" ] }, "reaction_10557190": { "compartment": "compartment_5460", "id": "reaction_10557190", "reactome": "R-CEL-5693977", "name": "AMT transfers NH2CH2 from GCSH:SAMDLL to THF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200671", "species_10557169" ], "products": [ "species_10557182", "species_5693978", "species_5693984" ], "modifiers": [ [ "species_10557187", "catalyst" ] ], "additional_components": [ "CHEBI:14949", "Q20634", "WBGene00009918", "CHEBI:50746", "Q20634", "WBGene00009918", "WBGene00017765" ] }, "reaction_10557195": { "compartment": "compartment_5460", "id": "reaction_10557195", "reactome": "R-CEL-5694018", "name": "DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10557182", "species_113526" ], "products": [ "species_10557165", "species_113529", "species_29362" ], "modifiers": [ [ "species_10557192", "catalyst" ] ], "additional_components": [ "CHEBI:50746", "Q20634", "WBGene00009918", "WBGene00009918", "O17953", "WBGene00010794", "species_113596" ] }, "reaction_10557180": { "compartment": "compartment_5460", "id": "reaction_10557180", "reactome": "R-CEL-5693967", "name": "PXLP-K754-GLDC dimer decarboxylates Gly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_159549", "species_10557165" ], "products": [ "species_10557169", "species_29376" ], "modifiers": [ [ "species_10557177", "catalyst" ] ], "additional_components": [ "WBGene00009918", "CHEBI:14949", "Q20634", "WBGene00009918", "Q21962", "WBGene00020022" ] }, "reaction_10520733": { "compartment": "compartment_17951", "id": "reaction_10520733", "reactome": "R-CEL-389842", "name": "HAO1 tetramer oxidizes glycolate to glyoxylate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113535", "species_389822" ], "products": [ "species_389678", "species_113575" ], "modifiers": [ [ "species_10520730", "catalyst" ] ], "additional_components": [ "B1GRK5", "WBGene00018286", "species_73524" ] }, "reaction_10503876": { "compartment": "compartment_70101", "id": "reaction_10503876", "reactome": "R-CEL-71249", "name": "SHMT1 tetramer cleaves HTMLYS to yield TEABL and Gly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_31503" ], "products": [ "species_31311", "species_29424" ], "modifiers": [ [ "species_10503873", "catalyst" ] ], "additional_components": [ "P50432", "WBGene00003214" ] }, "reaction_10503865": { "compartment": "compartment_5460", "id": "reaction_10503865", "reactome": "R-CEL-71241", "name": "TMLHE dimer dioxygenates TMLYS and 2OG to form HTMLYS and SUCCA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113533", "species_113594", "species_35139" ], "products": [ "species_113546", "species_113536", "species_29376" ], "modifiers": [ [ "species_10503862", "catalyst" ] ], "additional_components": [ "Q21526", "WBGene00001523", "species_198836", "species_113531" ] }, "reaction_10503886": { "compartment": "compartment_70101", "id": "reaction_10503886", "reactome": "R-CEL-71260", "name": "ALDH9A1 tetramer dehydrogenates TEABL to form TEABT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_31311", "species_29356", "species_29360" ], "products": [ "species_70106", "species_31369", "species_73473" ], "modifiers": [ [ "species_10503883", "catalyst" ] ], "additional_components": [ "Q20352", "WBGene00000117" ] }, "reaction_10534694": { "compartment": "compartment_5460", "id": "reaction_10534694", "reactome": "R-CEL-1475028", "name": "Carbonic anhydrase dehydrates bicarbonate (mitochondria)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29896", "species_113529" ], "products": [ "species_113521", "species_29376" ], "modifiers": [ [ "species_10534691", "catalyst" ] ], "additional_components": [ "species_216785", "O02637", "WBGene00000284", "Q10462", "WBGene00000283", "Q21614", "WBGene00000282", "Q27504", "WBGene00000281" ] }, "reaction_10534663": { "compartment": "compartment_70101", "id": "reaction_10534663", "reactome": "R-CEL-1475022", "name": "Carbonic anhydrase dehydrates bicarbonate (cytosol)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_111627" ], "products": [ "species_29356", "species_113528" ], "modifiers": [ [ "species_10534660", "catalyst" ] ], "additional_components": [ "O02637", "WBGene00000284", "Q10462", "WBGene00000283", "Q21614", "WBGene00000282", "Q27504", "WBGene00000281", "species_216785" ] }, "reaction_10534696": { "compartment": "compartment_5460", "id": "reaction_10534696", "reactome": "R-CEL-1475032", "name": "Carbonic anhydrase hydrates carbon dioxide (mitochondria)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113521", "species_29376" ], "products": [ "species_29896", "species_113529" ], "modifiers": [ [ "species_10534691", "catalyst" ] ], "additional_components": [ "species_216785", "O02637", "WBGene00000284", "Q10462", "WBGene00000283", "Q21614", "WBGene00000282", "Q27504", "WBGene00000281" ] }, "reaction_10534665": { "compartment": "compartment_70101", "id": "reaction_10534665", "reactome": "R-CEL-1475026", "name": "Carbonic anhydrase hydrates carbon dioxide (cytosol)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113528" ], "products": [ "species_70106", "species_111627" ], "modifiers": [ [ "species_10534660", "catalyst" ] ], "additional_components": [ "O02637", "WBGene00000284", "Q10462", "WBGene00000283", "Q21614", "WBGene00000282", "Q27504", "WBGene00000281", "species_216785" ] }, "reaction_10537601": { "compartment": "compartment_70101", "id": "reaction_10537601", "reactome": "R-CEL-1855166", "name": "PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_2023943" ], "products": [ "species_29372", "species_994141" ], "modifiers": [ [ "species_10537589", "catalyst" ] ], "additional_components": [ "species_1629736", "species_1629755", "CHEBI:62927", "Q95XC4", "WBGene00022366", "species_114632", "species_266099" ] }, "reaction_10537634": { "compartment": "compartment_70101", "id": "reaction_10537634", "reactome": "R-CEL-1855179", "name": "I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_994141" ], "products": [ "species_29370", "species_1629770" ], "modifiers": [ [ "species_10537631", "catalyst" ] ], "additional_components": [ "WBGene00012466" ] }, "reaction_10537666": { "compartment": "compartment_70101", "id": "reaction_10537666", "reactome": "R-CEL-1855194", "name": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/3 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1629740" ], "products": [ "species_1629732", "species_29370" ], "modifiers": [ [ "species_10537575", "catalyst" ] ], "additional_components": [ "Q9BKX8", "WBGene00021260", "O02167", "WBGene00021260", "Q93644", "WBGene00021260" ] }, "reaction_10537764": { "compartment": "compartment_70101", "id": "reaction_10537764", "reactome": "R-CEL-1855227", "name": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1629770" ], "products": [ "species_1629765", "species_29370" ], "modifiers": [ [ "species_10537575", "catalyst" ] ], "additional_components": [ "Q9BKX8", "WBGene00021260", "O02167", "WBGene00021260", "Q93644", "WBGene00021260" ] }, "reaction_10541476": { "compartment": "compartment_70101", "id": "reaction_10541476", "reactome": "R-CEL-2023971", "name": "1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_2023974" ], "products": [ "species_29372", "species_1629770" ], "modifiers": [ [ "species_10537595", "catalyst" ] ], "additional_components": [ "species_1629740", "CHEBI:62922", "species_114632", "Q95XC4", "WBGene00022366", "species_266099" ] }, "reaction_10537669": { "compartment": "compartment_70101", "id": "reaction_10537669", "reactome": "R-CEL-1855198", "name": "5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1629765", "species_29356" ], "products": [ "species_29372", "species_1629770" ], "modifiers": [ [ "species_10537595", "catalyst" ] ], "additional_components": [ "species_114632", "Q95XC4", "WBGene00022366", "species_266099" ] }, "reaction_10541478": { "compartment": "compartment_70101", "id": "reaction_10541478", "reactome": "R-CEL-2023973", "name": "(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2023968", "species_29356" ], "products": [ "species_29372", "species_2023974" ], "modifiers": [ [ "species_10537595", "catalyst" ] ], "additional_components": [ "species_1629732", "CHEBI:62924", "species_1629740", "CHEBI:62922", "species_114632", "Q95XC4", "WBGene00022366", "species_266099" ] }, "reaction_10537578": { "compartment": "compartment_70101", "id": "reaction_10537578", "reactome": "R-CEL-1855158", "name": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1629765", "species_113592" ], "products": [ "species_29370", "species_1629759" ], "modifiers": [ [ "species_10537575", "catalyst" ] ], "additional_components": [ "Q9BKX8", "WBGene00021260", "O02167", "WBGene00021260", "Q93644", "WBGene00021260" ] }, "reaction_10537652": { "compartment": "compartment_70101", "id": "reaction_10537652", "reactome": "R-CEL-1855182", "name": "5-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by PPIP5K1/2 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1629765", "species_113592" ], "products": [ "species_1629732", "species_29370" ], "modifiers": [ [ "species_10537649", "catalyst" ] ], "additional_components": [ "P91309", "WBGene00018508" ] }, "reaction_10537758": { "compartment": "compartment_70101", "id": "reaction_10537758", "reactome": "R-CEL-1855223", "name": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/3 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_994141" ], "products": [ "species_29370", "species_1629755" ], "modifiers": [ [ "species_10537575", "catalyst" ] ], "additional_components": [ "Q9BKX8", "WBGene00021260", "O02167", "WBGene00021260", "Q93644", "WBGene00021260" ] }, "reaction_10537726": { "compartment": "compartment_70101", "id": "reaction_10537726", "reactome": "R-CEL-1855216", "name": "IP6 is phosphorylated to 1-PP-IP5 by PPIP5K1/2 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1629770" ], "products": [ "species_29370", "species_1629740" ], "modifiers": [ [ "species_10537649", "catalyst" ] ], "additional_components": [ "P91309", "WBGene00018508" ] }, "reaction_10537598": { "compartment": "compartment_70101", "id": "reaction_10537598", "reactome": "R-CEL-1855165", "name": "(PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2023968", "species_29356" ], "products": [ "species_1629765", "species_29372" ], "modifiers": [ [ "species_10537595", "catalyst" ] ], "additional_components": [ "species_1629732", "CHEBI:62924", "species_114632", "Q95XC4", "WBGene00022366", "species_266099" ] }, "reaction_10537663": { "compartment": "compartment_70101", "id": "reaction_10537663", "reactome": "R-CEL-1855193", "name": "1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1629736" ], "products": [ "species_29370", "species_1629738" ], "modifiers": [ [ "species_10537575", "catalyst" ] ], "additional_components": [ "Q9BKX8", "WBGene00021260", "O02167", "WBGene00021260", "Q93644", "WBGene00021260" ] }, "reaction_10555333": { "compartment": "compartment_70101", "id": "reaction_10555333", "reactome": "R-CEL-5678327", "name": "MIOX oxidises Ins to GlcA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_426910" ], "products": [ "species_29356", "species_70106", "species_2162232" ], "modifiers": [ [ "species_10555330", "catalyst" ] ], "additional_components": [ "Q65CM5", "WBGene00016920", "species_113531" ] }, "reaction_10537637": { "compartment": "compartment_70101", "id": "reaction_10537637", "reactome": "R-CEL-1855180", "name": "I(1,3,4)P3 is dephosphorylated to I(1,3)P2 by INPP4A/B in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_994123" ], "products": [ "species_29372", "species_1629769" ], "modifiers": [ [ "species_10537307", "catalyst" ] ], "additional_components": [ "Q21623", "WBGene00010975" ] }, "reaction_10537606": { "compartment": "compartment_70101", "id": "reaction_10537606", "reactome": "R-CEL-1855174", "name": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_114520" ], "products": [ "species_29372", "species_1629739" ], "modifiers": [ [ "species_10537603", "catalyst" ] ], "additional_components": [ "O17590", "WBGene00007620", "P34370", "WBGene00086546", "G5ECL2", "WBGene00006763" ] }, "reaction_10537686": { "compartment": "compartment_70101", "id": "reaction_10537686", "reactome": "R-CEL-1855210", "name": "I3P is dephosphorylated to Ins by IMPA1/2 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1629731" ], "products": [ "species_29372", "species_426910" ], "modifiers": [ [ "species_10537530", "catalyst" ] ], "additional_components": [ "species_114632", "Q19420", "WBGene00008765" ] }, "reaction_10537672": { "compartment": "compartment_70101", "id": "reaction_10537672", "reactome": "R-CEL-1855202", "name": "I(3,4)P2 is dephosphorylated to I3P by INPP4A/B in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1629746" ], "products": [ "species_29372", "species_1629731" ], "modifiers": [ [ "species_10537307", "catalyst" ] ], "additional_components": [ "Q21623", "WBGene00010975" ] }, "reaction_10537689": { "compartment": "compartment_70101", "id": "reaction_10537689", "reactome": "R-CEL-1855211", "name": "I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1629753" ], "products": [ "species_29372", "species_426910" ], "modifiers": [ [ "species_10537530", "catalyst" ] ], "additional_components": [ "species_114632", "Q19420", "WBGene00008765" ] }, "reaction_10537755": { "compartment": "compartment_876", "id": "reaction_10537755", "reactome": "R-CEL-1855222", "name": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_114520" ], "products": [ "species_29372", "species_1629739" ], "modifiers": [ [ "species_10537752", "catalyst" ] ], "additional_components": [ "Q17848", "WBGene00002146", "O17590", "WBGene00007620" ] }, "reaction_10537533": { "compartment": "compartment_70101", "id": "reaction_10537533", "reactome": "R-CEL-1855154", "name": "I1P is dephosphorylated to Ins by IMPA1/2 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_870330" ], "products": [ "species_29372", "species_426910" ], "modifiers": [ [ "species_10537530", "catalyst" ] ], "additional_components": [ "species_114632", "Q19420", "WBGene00008765" ] }, "reaction_10537629": { "compartment": "compartment_70101", "id": "reaction_10537629", "reactome": "R-CEL-1855178", "name": "Glc6P is isomerised to I3P by ISYNA1 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1629756" ], "products": [ "species_1629731" ], "modifiers": [ [ "species_10537626", "catalyst" ] ], "additional_components": [ "species_29360", "G5ED01", "WBGene00012148" ] }, "reaction_10520816": { "compartment": "compartment_17951", "id": "reaction_10520816", "reactome": "R-CEL-390425", "name": "FAR1 reduces PalmCoA to HXOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_200993" ], "products": [ "species_29366", "species_8848577", "species_76194" ], "modifiers": [ [ "species_10520813", "catalyst" ] ], "additional_components": [ "WBGene00022200" ] }, "reaction_10564721": { "compartment": "compartment_12045", "id": "reaction_10564721", "reactome": "R-CEL-8848582", "name": "AWAT2 transfers PALM from PALM-CoA to HXOL, forming palmityl palmitate ester", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8848577", "species_200993" ], "products": [ "species_8848499", "species_76194" ], "modifiers": [ [ "species_10557641", "catalyst" ] ], "additional_components": [ "O01881", "WBGene00021818", "Q23067", "WBGene00020910", "Q9N4S3", "WBGene00021818", "Q9XUW0", "WBGene00010296" ] }, "reaction_10564724": { "compartment": "compartment_12045", "id": "reaction_10564724", "reactome": "R-CEL-8848585", "name": "AWAT2 transfers PALM from PALM-CoA to atROL, forming atR-PALM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200993", "species_30209" ], "products": [ "species_76194", "species_2534407" ], "modifiers": [ [ "species_10557641", "catalyst" ] ], "additional_components": [ "O01881", "WBGene00021818", "Q23067", "WBGene00020910", "Q9N4S3", "WBGene00021818", "Q9XUW0", "WBGene00010296" ] }, "reaction_10557631": { "compartment": "compartment_12045", "id": "reaction_10557631", "reactome": "R-CEL-5696424", "name": "AWAT1 transfers acyl group from acyl-CoA to ARACOH, forming wax esters", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_192172", "species_5696426" ], "products": [ "species_5696412", "species_162743" ], "modifiers": [ [ "species_10557628", "catalyst" ] ], "additional_components": [ "O01881", "WBGene00021818", "Q23067", "WBGene00020910", "Q9N4S3", "WBGene00021818", "Q9XUW0", "WBGene00010296" ] }, "reaction_10520819": { "compartment": "compartment_17951", "id": "reaction_10520819", "reactome": "R-CEL-390427", "name": "1-palmitoylglycerone phosphate + hexadecanol => O-hexadecylglycerone phosphate + palmitate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_390440", "species_390419" ], "products": [ "species_390409", "species_390435" ], "modifiers": [ [ "species_10507473", "catalyst" ] ], "additional_components": [ "G5EFP8", "WBGene00012911", "species_113596", "O45218", "WBGene00000081" ] }, "reaction_10507476": { "compartment": "compartment_17951", "id": "reaction_10507476", "reactome": "R-CEL-75879", "name": "palmitoyl-CoA + DHAP => 1-palmitoylglycerone phosphate + CoASH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_390426", "species_390404" ], "products": [ "species_193514", "species_390419" ], "modifiers": [ [ "species_10507473", "catalyst" ] ], "additional_components": [ "G5EFP8", "WBGene00012911", "species_113596", "O45218", "WBGene00000081" ] }, "reaction_10507484": { "compartment": "compartment_70101", "id": "reaction_10507484", "reactome": "R-CEL-75883", "name": "DHRS7B reduces GO3P to HXDG3P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_75973", "species_29364" ], "products": [ "species_29366", "species_390422" ], "modifiers": [ [ "species_10507481", "catalyst" ] ], "additional_components": [ "WBGene00000993" ] }, "reaction_10537136": { "compartment": "compartment_12045", "id": "reaction_10537136", "reactome": "R-CEL-1675813", "name": "PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_426639" ], "products": [ "species_29370", "species_1806234" ], "modifiers": [ [ "species_10537133", "catalyst" ] ], "additional_components": [ "O45318", "WBGene00022501", "Q23083", "WBGene00022501", "Q9XW63", "WBGene00013557" ] }, "reaction_10563689": { "compartment": "compartment_70101", "id": "reaction_10563689", "reactome": "R-CEL-6809764", "name": "SBF1 binds MTMR2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10563685", "species_10537108" ], "products": [ "species_10563687" ], "modifiers": [], "additional_components": [ "WBGene00003477", "WBGene00003475", "Q9N589", "WBGene00003475", "Q9TXP3", "WBGene00003477" ] }, "reaction_10537277": { "compartment": "compartment_12045", "id": "reaction_10537277", "reactome": "R-CEL-1676124", "name": "PI4P is dephosphorylated to PI by SACM1L at the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1806234" ], "products": [ "species_29372", "species_426639" ], "modifiers": [ [ "species_10537274", "catalyst" ] ], "additional_components": [ "WBGene00009264" ] }, "reaction_10563692": { "compartment": "compartment_70101", "id": "reaction_10563692", "reactome": "R-CEL-6809777", "name": "PI3P is dephosphorylated to PI by MTMR2:SBF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_5676030" ], "products": [ "species_29372", "species_426639" ], "modifiers": [ [ "species_10563687", "catalyst" ] ], "additional_components": [ "Q9N589", "WBGene00003475", "Q9TXP3", "WBGene00003477" ] }, "reaction_10563695": { "compartment": "compartment_70101", "id": "reaction_10563695", "reactome": "R-CEL-6809778", "name": "PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_6809774" ], "products": [ "species_29372", "species_422529" ], "modifiers": [ [ "species_10563687", "catalyst" ] ], "additional_components": [ "Q9N589", "WBGene00003475", "Q9TXP3", "WBGene00003477" ] }, "reaction_10537328": { "compartment": "compartment_171062", "id": "reaction_10537328", "reactome": "R-CEL-1676206", "name": "PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A at the early endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806180", "species_113592" ], "products": [ "species_29370", "species_1806238" ], "modifiers": [ [ "species_10537178", "catalyst" ] ], "additional_components": [ "G5EDY0", "WBGene00009552", "species_74016", "species_114632" ] }, "reaction_10563680": { "compartment": "compartment_171062", "id": "reaction_10563680", "reactome": "R-CEL-6809720", "name": "PI3P is dephosphorylated to PI by MTM1:MTMR12", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1806200" ], "products": [ "species_29372", "species_1806199" ], "modifiers": [ [ "species_10563671", "catalyst" ] ], "additional_components": [ "Q9N589", "WBGene00003475", "V6CJW9", "WBGene00021683" ] }, "reaction_10537219": { "compartment": "compartment_171062", "id": "reaction_10537219", "reactome": "R-CEL-1675974", "name": "PI is phosphorylated to PI4P by PI4K2A/B at the early endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806199", "species_113592" ], "products": [ "species_1806180", "species_29370" ], "modifiers": [ [ "species_10537098", "catalyst" ] ], "additional_components": [ "O45318", "WBGene00022501", "Q23083", "WBGene00022501" ] }, "reaction_10537286": { "compartment": "compartment_171062", "id": "reaction_10537286", "reactome": "R-CEL-1676141", "name": "PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1806200" ], "products": [ "species_29372", "species_1806199" ], "modifiers": [ [ "species_10537252", "catalyst" ] ], "additional_components": [ "Q9N589", "WBGene00003475", "Q22712", "WBGene00003476" ] }, "reaction_10537255": { "compartment": "compartment_171062", "id": "reaction_10537255", "reactome": "R-CEL-1676105", "name": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1806205" ], "products": [ "species_29372", "species_1806259" ], "modifiers": [ [ "species_10537252", "catalyst" ] ], "additional_components": [ "Q9N589", "WBGene00003475", "Q22712", "WBGene00003476" ] }, "reaction_10563673": { "compartment": "compartment_70101", "id": "reaction_10563673", "reactome": "R-CEL-6809680", "name": "MTMR12 binds MTM1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10563669", "species_10537106" ], "products": [ "species_10563671" ], "modifiers": [], "additional_components": [ "WBGene00021683", "WBGene00003475", "Q9N589", "WBGene00003475", "V6CJW9", "WBGene00021683" ] }, "reaction_10537196": { "compartment": "compartment_171062", "id": "reaction_10537196", "reactome": "R-CEL-1675939", "name": "PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806199", "species_113592" ], "products": [ "species_29370", "species_1806200" ], "modifiers": [ [ "species_10537193", "catalyst" ] ], "additional_components": [ "Q9TXI7", "WBGene00006932", "species_266099", "Q23669", "WBGene00014151", "G5EDY0", "WBGene00009552", "species_74016", "species_114632" ] }, "reaction_10563677": { "compartment": "compartment_70101", "id": "reaction_10563677", "reactome": "R-CEL-6809707", "name": "MTMR12 binds MTMR2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10563669", "species_10537108" ], "products": [ "species_10563675" ], "modifiers": [], "additional_components": [ "WBGene00021683", "WBGene00003475", "Q9N589", "WBGene00003475", "V6CJW9", "WBGene00021683" ] }, "reaction_10537310": { "compartment": "compartment_171062", "id": "reaction_10537310", "reactome": "R-CEL-1676162", "name": "PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1806238" ], "products": [ "species_29372", "species_1806200" ], "modifiers": [ [ "species_10537307", "catalyst" ] ], "additional_components": [ "Q21623", "WBGene00010975" ] }, "reaction_10564974": { "compartment": "compartment_70101", "id": "reaction_10564974", "reactome": "R-CEL-8849969", "name": "PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_8849959" ], "products": [ "species_29372", "species_8849958" ], "modifiers": [ [ "species_10564971", "catalyst" ] ], "additional_components": [ "species_179838", "species_202247", "species_179856", "species_1806200", "species_5334668", "species_6810408", "WBGene00012353" ] }, "reaction_10564261": { "compartment": "compartment_12045", "id": "reaction_10564261", "reactome": "R-CEL-6814254", "name": "PNPLA6 hydrolyzes LysoPtdCho", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_6814253" ], "products": [ "species_1498750", "species_1524021" ], "modifiers": [ [ "species_10564258", "catalyst" ] ], "additional_components": [ "Q21534", "WBGene00022718", "Q02331", "WBGene00022718" ] }, "reaction_10564484": { "compartment": "compartment_876", "id": "reaction_10564484", "reactome": "R-CEL-6814797", "name": "ENPP6 hydrolyzes lysophosphatidylcholine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_2239407" ], "products": [ "species_6814794", "species_6814795" ], "modifiers": [ [ "species_10564481", "catalyst" ] ], "additional_components": [ "O45359", "WBGene00020195", "Q17540", "WBGene00020195", "Q22129", "WBGene00020195" ] }, "reaction_10564134": { "compartment": "compartment_876", "id": "reaction_10564134", "reactome": "R-CEL-6813740", "name": "GDE1 hydrolyzes GroPIns", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_6813734" ], "products": [ "species_426910", "species_76114" ], "modifiers": [ [ "species_10564131", "catalyst" ] ], "additional_components": [ "WBGene00020446" ] }, "reaction_10542310": { "compartment": "compartment_17957", "id": "reaction_10542310", "reactome": "R-CEL-2046092", "name": "Desaturation of dihomo-gamma-lenolenoyl-CoA to arachidonoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_194697", "species_2046045" ], "products": [ "species_194653", "species_113519", "species_2046053" ], "modifiers": [ [ "species_10542305", "catalyst" ] ], "additional_components": [ "G5EG11", "WBGene00001396", "Q23221", "WBGene00001395" ] }, "reaction_10542312": { "compartment": "compartment_12045", "id": "reaction_10542312", "reactome": "R-CEL-2046093", "name": "Translocation of tetracosapentaenoyl-CoA to peroxisomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2046050", "species_211579" ], "products": [ "species_5228339", "species_2046055", "species_211606" ], "modifiers": [ [ "species_10520379", "catalyst" ] ], "additional_components": [ "WBGene00004061" ] }, "reaction_10542314": { "compartment": "compartment_17957", "id": "reaction_10542314", "reactome": "R-CEL-2046094", "name": "Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2046066", "species_2046042", "species_113601" ], "products": [ "species_113519", "species_113564", "species_162743", "species_159751", "species_2046045" ], "modifiers": [ [ "species_10527261", "catalyst" ] ], "additional_components": [ "WBGene00001241" ] }, "reaction_10542316": { "compartment": "compartment_12045", "id": "reaction_10542316", "reactome": "R-CEL-2046096", "name": "Desaturation of Linoleoyl-CoA to gamma-linolenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_194697", "species_2046063" ], "products": [ "species_194653", "species_113519", "species_2046042" ], "modifiers": [ [ "species_10542288", "catalyst" ] ], "additional_components": [ "WBGene00001395" ] }, "reaction_10542318": { "compartment": "compartment_17957", "id": "reaction_10542318", "reactome": "R-CEL-2046097", "name": "Desaturation of tetracosatetraenoyl-CoA to tetracosapentaenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_2046048", "species_194697" ], "products": [ "species_194653", "species_113519", "species_2046050" ], "modifiers": [ [ "species_10542288", "catalyst" ] ], "additional_components": [ "WBGene00001395" ] }, "reaction_10557520": { "compartment": "compartment_5460", "id": "reaction_10557520", "reactome": "R-CEL-5695989", "name": "ACAD11 dehydrogenates BH-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113596", "species_5695963" ], "products": [ "species_5695976", "species_31649" ], "modifiers": [ [ "species_10557517", "catalyst" ] ], "additional_components": [ "WBGene00019599" ] }, "reaction_10556512": { "compartment": "compartment_70101", "id": "reaction_10556512", "reactome": "R-CEL-5690043", "name": "Cytosolic ACOTs hydrolyse MCFA-CoA, LCFA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_5690044" ], "products": [ "species_5690064", "species_76194" ], "modifiers": [ [ "species_10556509", "catalyst" ] ], "additional_components": [ "species_5690542", "species_164991", "species_5690531", "species_174602", "O45003", "WBGene00020989", "Q9GYN3", "WBGene00020989", "B3WFZ3", "WBGene00020989", "O01862", "WBGene00020989", "P34419", "WBGene00018370" ] }, "reaction_10567219": { "compartment": "compartment_5460", "id": "reaction_10567219", "reactome": "R-CEL-8874745", "name": "ACAA2 tetramer transfers acyl group from Ac-CoA to acyl-CoA forming 3OA-CoA and CoA-SH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113559", "species_1524038" ], "products": [ "species_29374", "species_8874749" ], "modifiers": [ [ "species_10567216", "catalyst" ] ], "additional_components": [ "O45552", "WBGene00009952" ] }, "reaction_10564674": { "compartment": "compartment_70101", "id": "reaction_10564674", "reactome": "R-CEL-8848250", "name": "ACBD6 binds LCFA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10564670", "species_164991" ], "products": [ "species_10564672" ], "modifiers": [], "additional_components": [ "WBGene00011731", "species_164991", "Q9XVJ0", "WBGene00011731" ] }, "reaction_10564645": { "compartment": "compartment_17957", "id": "reaction_10564645", "reactome": "R-CEL-8848246", "name": "DBI, ACBD7 bind MCFA-CoA and LCFA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8848288", "species_10564641" ], "products": [ "species_10564643" ], "modifiers": [], "additional_components": [ "species_164991", "species_5690542", "Q09603", "WBGene00001153", "Q09603", "WBGene00001153", "species_164991", "species_5690542" ] }, "reaction_10556532": { "compartment": "compartment_5460", "id": "reaction_10556532", "reactome": "R-CEL-5690066", "name": "ACOT2,9,THEM4,5 hydrolyse MCFA-CoA, LCFA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5690540", "species_113521" ], "products": [ "species_29374", "species_5690519" ], "modifiers": [ [ "species_10556529", "catalyst" ] ], "additional_components": [ "species_164991", "species_5690542", "species_174602", "species_5690531", "B3WFZ3", "WBGene00020989", "O01862", "WBGene00020989", "O45003", "WBGene00020989", "Q9GYN3", "WBGene00020989", "Q94245", "WBGene00019015" ] }, "reaction_10503674": { "compartment": "compartment_5460", "id": "reaction_10503674", "reactome": "R-CEL-71020", "name": "D-methylmalonyl-CoA <=> L-methylmalonyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71019" ], "products": [ "species_71009" ], "modifiers": [ [ "species_10503671", "catalyst" ] ], "additional_components": [ "WBGene00008415" ] }, "reaction_10503692": { "compartment": "compartment_5460", "id": "reaction_10503692", "reactome": "R-CEL-71031", "name": "propionyl-CoA + CO2 + ATP <=> D-methylmalonyl-CoA + ADP + orthophosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70843", "species_113593", "species_29376" ], "products": [ "species_113548", "species_113581", "species_71019" ], "modifiers": [ [ "species_10503689", "catalyst" ] ], "additional_components": [ "Q19842", "WBGene00017864", "Q20676", "WBGene00018701" ] }, "reaction_10508264": { "compartment": "compartment_5460", "id": "reaction_10508264", "reactome": "R-CEL-77338", "name": "Octanoyl-CoA+FAD<=>trans-Oct-2-enoyl-CoA+FADH2", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113596", "species_77337" ], "products": [ "species_77332", "species_31649" ], "modifiers": [ [ "species_10508261", "catalyst" ] ], "additional_components": [ "Q22347", "WBGene00020366" ] }, "reaction_10508250": { "compartment": "compartment_5460", "id": "reaction_10508250", "reactome": "R-CEL-77329", "name": "3-Oxooctanoyl-CoA+CoA-SH<=>Hexanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_77328" ], "products": [ "species_77326", "species_113559" ], "modifiers": [ [ "species_10508211", "catalyst" ] ], "additional_components": [ "P34255", "WBGene00015125", "Q9GYT0", "WBGene00020347" ] }, "reaction_10508252": { "compartment": "compartment_5460", "id": "reaction_10508252", "reactome": "R-CEL-77331", "name": "(S)-Hydroxyoctanoyl-CoA+NAD<=>3-Oxooctanoyl-CoA+NADH+H", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113526", "species_77330" ], "products": [ "species_113529", "species_29362", "species_77328" ], "modifiers": [ [ "species_10508194", "catalyst" ] ], "additional_components": [ "P41938", "WBGene00007129" ] }, "reaction_10508254": { "compartment": "compartment_5460", "id": "reaction_10508254", "reactome": "R-CEL-77333", "name": "trans-Oct-2-enoyl-CoA+H2O<=>(S)-Hydroxyoctanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77332", "species_113521" ], "products": [ "species_77330" ], "modifiers": [ [ "species_10503463", "catalyst" ] ], "additional_components": [ "P34559", "WBGene00001155" ] }, "reaction_10508272": { "compartment": "compartment_5460", "id": "reaction_10508272", "reactome": "R-CEL-77345", "name": "Decanoyl-CoA+FAD<=>trans-Dec-2-enoyl-CoA+FADH2", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77308", "species_113596" ], "products": [ "species_77343", "species_31649" ], "modifiers": [ [ "species_10508261", "catalyst" ] ], "additional_components": [ "Q22347", "WBGene00020366" ] }, "reaction_10569787": { "compartment": "compartment_5460", "id": "reaction_10569787", "reactome": "R-CEL-8952873", "name": "MECR dimer reduces tdec2-CoA to DEC-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77343", "species_113529", "species_113600" ], "products": [ "species_77308", "species_113563" ], "modifiers": [ [ "species_10569784", "catalyst" ] ], "additional_components": [ "O45903", "WBGene00012375" ] }, "reaction_10508266": { "compartment": "compartment_5460", "id": "reaction_10508266", "reactome": "R-CEL-77340", "name": "3-Oxodecanoyl-CoA+CoA-SH<=>Octanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_77339" ], "products": [ "species_77337", "species_113559" ], "modifiers": [ [ "species_10508211", "catalyst" ] ], "additional_components": [ "P34255", "WBGene00015125", "Q9GYT0", "WBGene00020347" ] }, "reaction_10508268": { "compartment": "compartment_5460", "id": "reaction_10508268", "reactome": "R-CEL-77342", "name": "(S)-Hydroxydecanoyl-CoA+NAD<=>3-Oxodecanoyl-CoA+NADH+H", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77341", "species_113526" ], "products": [ "species_77339", "species_113529", "species_29362" ], "modifiers": [ [ "species_10508194", "catalyst" ] ], "additional_components": [ "P41938", "WBGene00007129" ] }, "reaction_10508270": { "compartment": "compartment_5460", "id": "reaction_10508270", "reactome": "R-CEL-77344", "name": "trans-Dec-2-enoyl-CoA+H2O<=>(S)-Hydroxydecanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77343", "species_113521" ], "products": [ "species_77341" ], "modifiers": [ [ "species_10503463", "catalyst" ] ], "additional_components": [ "P34559", "WBGene00001155" ] }, "reaction_10508230": { "compartment": "compartment_5460", "id": "reaction_10508230", "reactome": "R-CEL-77299", "name": "palmitoyl-CoA+FAD<=>trans-Hexadec-2-enoyl-CoA+FADH2", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113596", "species_77281" ], "products": [ "species_77284", "species_31649" ], "modifiers": [ [ "species_10508227", "catalyst" ] ], "additional_components": [ "Q19057", "WBGene00017125" ] }, "reaction_10508232": { "compartment": "compartment_5460", "id": "reaction_10508232", "reactome": "R-CEL-77301", "name": "trans-Hexadec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxyhexadecanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77284", "species_113521" ], "products": [ "species_77300" ], "modifiers": [ [ "species_10508211", "catalyst" ] ], "additional_components": [ "P34255", "WBGene00015125", "Q9GYT0", "WBGene00020347" ] }, "reaction_10508234": { "compartment": "compartment_5460", "id": "reaction_10508234", "reactome": "R-CEL-77303", "name": "(S)-3-Hydroxyhexadecanoyl-CoA+NAD<=>3-Oxopalmitoyl-CoA+NADH+H", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113526", "species_77300" ], "products": [ "species_113529", "species_77302", "species_29362" ], "modifiers": [ [ "species_10508211", "catalyst" ] ], "additional_components": [ "P34255", "WBGene00015125", "Q9GYT0", "WBGene00020347" ] }, "reaction_10508236": { "compartment": "compartment_5460", "id": "reaction_10508236", "reactome": "R-CEL-77304", "name": "3-Oxopalmitoyl-CoA+CoA-SH<=>myristoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_77302" ], "products": [ "species_77272", "species_113559" ], "modifiers": [ [ "species_10508211", "catalyst" ] ], "additional_components": [ "P34255", "WBGene00015125", "Q9GYT0", "WBGene00020347" ] }, "reaction_10557528": { "compartment": "compartment_5460", "id": "reaction_10557528", "reactome": "R-CEL-5696004", "name": "ACSF2 ligates CoA-SH to MCFA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_113593", "species_5690531" ], "products": [ "species_159448", "species_159450", "species_5690542" ], "modifiers": [ [ "species_10557525", "catalyst" ] ], "additional_components": [ "WBGene00018488" ] }, "reaction_10508370": { "compartment": "compartment_5460", "id": "reaction_10508370", "reactome": "R-CEL-109341", "name": "dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113596", "species_109986" ], "products": [ "species_109990", "species_31649" ], "modifiers": [ [ "species_10508261", "catalyst" ] ], "additional_components": [ "Q22347", "WBGene00020366" ] }, "reaction_10508380": { "compartment": "compartment_5460", "id": "reaction_10508380", "reactome": "R-CEL-109343", "name": "Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113529", "species_109990", "species_29362" ], "products": [ "species_109994", "species_113526" ], "modifiers": [ [ "species_10508377", "catalyst" ] ], "additional_components": [ "Q23116", "WBGene00012177" ] }, "reaction_10542993": { "compartment": "compartment_12045", "id": "reaction_10542993", "reactome": "R-CEL-2161814", "name": "Arachidonic acid is hydroxylated to 19-HETE by CYP(2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_140356", "species_113601" ], "products": [ "species_113519", "species_113564", "species_2142836" ], "modifiers": [ [ "species_10542990", "catalyst" ] ], "additional_components": [ "A0A0M7RF98", "WBGene00018264", "Q27465", "WBGene00015135", "G5ECD0", "WBGene00007362", "Q27470", "WBGene00015709", "G5EE22", "WBGene00012448", "Q27471", "WBGene00016092", "H2KY69", "WBGene00015044", "Q27482", "WBGene00016768", "H2KYS3", "WBGene00000905", "Q27499", "WBGene00018334", "O02627", "WBGene00015399", "Q965T7", "WBGene00021710", "O02628", "WBGene00015400", "Q9N4Q4", "WBGene00021168", "O02641", "WBGene00019967", "Q9N5I1", "WBGene00019565", "O16220", "WBGene00016786", "O16362", "WBGene00018413", "O16482", "WBGene00016860", "O16670", "WBGene00018262", "O16671", "WBGene00018261", "O16673", "WBGene00018260", "O44649", "WBGene00019473", "O44650", "WBGene00019472", "O44651", "WBGene00019471", "O44652", "WBGene00019470", "O44655", "WBGene00015040", "O44656", "WBGene00015041", "O44657", "WBGene00015042", "O44658", "WBGene00015043", "O44704", "WBGene00016686", "O44706", "WBGene00016697", "O45364", "WBGene00008829", "O45659", "WBGene00010589", "O61204", "WBGene00015045", "O61935", "WBGene00020386", "O62377", "WBGene00011699", "O62378", "WBGene00011698", "P90771", "WBGene00007913", "Q20315", "WBGene00018333", "Q9N525", "WBGene00021412", "O17851", "WBGene00009226", "Q9N574", "WBGene00021200", "O45219", "WBGene00007140", "G5EC97", "WBGene00011830", "Q9XVA6", "WBGene00008499", "Q09660", "WBGene00000375", "G5EGT6", "WBGene00010354" ] }, "reaction_10543003": { "compartment": "compartment_12045", "id": "reaction_10543003", "reactome": "R-CEL-2161940", "name": "Arachidonic acid is hydroxylated to 20-HETE by CYP(3)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_140356", "species_113601" ], "products": [ "species_113519", "species_113564", "species_2142780" ], "modifiers": [ [ "species_10543000", "catalyst" ] ], "additional_components": [ "A0A0M7RF98", "WBGene00018264", "Q27465", "WBGene00015135", "G5ECD0", "WBGene00007362", "Q27470", "WBGene00015709", "G5EE22", "WBGene00012448", "Q27471", "WBGene00016092", "H2KY69", "WBGene00015044", "Q27482", "WBGene00016768", "H2KYS3", "WBGene00000905", "Q27499", "WBGene00018334", "O02627", "WBGene00015399", "Q965T7", "WBGene00021710", "O02628", "WBGene00015400", "Q9N4Q4", "WBGene00021168", "O02641", "WBGene00019967", "Q9N5I1", "WBGene00019565", "O16220", "WBGene00016786", "O16362", "WBGene00018413", "O16482", "WBGene00016860", "O16670", "WBGene00018262", "O16671", "WBGene00018261", "O16673", "WBGene00018260", "O44649", "WBGene00019473", "O44650", "WBGene00019472", "O44651", "WBGene00019471", "O44652", "WBGene00019470", "O44655", "WBGene00015040", "O44656", "WBGene00015041", "O44657", "WBGene00015042", "O44658", "WBGene00015043", "O44704", "WBGene00016686", "O44706", "WBGene00016697", "O45364", "WBGene00008829", "O45659", "WBGene00010589", "O61204", "WBGene00015045", "O61935", "WBGene00020386", "O62377", "WBGene00011699", "O62378", "WBGene00011698", "P90771", "WBGene00007913", "Q20315", "WBGene00018333", "Q9XVA6", "WBGene00008499", "G5EC97", "WBGene00011830", "G5EGT6", "WBGene00010354", "O17851", "WBGene00009226", "O45219", "WBGene00007140", "Q09660", "WBGene00000375", "Q9N525", "WBGene00021412", "Q9N574", "WBGene00021200" ] }, "reaction_10557108": { "compartment": "compartment_12045", "id": "reaction_10557108", "reactome": "R-CEL-5693742", "name": "FAAH hydrolyses AEA to AA and ETA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_5693754" ], "products": [ "species_1498751", "species_29768" ], "modifiers": [ [ "species_10557105", "catalyst" ] ], "additional_components": [ "Q17449", "WBGene00015047", "Q9U217", "WBGene00013232", "O45089", "WBGene00019068", "Q17447", "WBGene00015048", "Q9U243", "WBGene00013226", "Q9U2I8", "WBGene00012750" ] }, "reaction_10568057": { "compartment": "compartment_984", "id": "reaction_10568057", "reactome": "R-CEL-8932633", "name": "PON1,2,3:Ca2+ dimers hydrolyse 5-HETEL to 5-HETE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_8932801" ], "products": [ "species_8932804" ], "modifiers": [ [ "species_10568054", "catalyst" ] ], "additional_components": [ "species_74016", "B1V898", "WBGene00077701", "O01811", "WBGene00003170", "Q21427", "WBGene00010775", "Q2V071", "WBGene00044697", "Q966L1", "WBGene00017089" ] }, "reaction_10517856": { "compartment": "compartment_876", "id": "reaction_10517856", "reactome": "R-CEL-266070", "name": "LTC4 is exported from the cytosol by ABCC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_266066" ], "products": [ "species_266013" ], "modifiers": [ [ "species_10517853", "catalyst" ] ], "additional_components": [ "WBGene00003407" ] }, "reaction_10517848": { "compartment": "compartment_876", "id": "reaction_10517848", "reactome": "R-CEL-266046", "name": "GGT1, 5 dimers hydrolyse LTC4 to LTD4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_266013" ], "products": [ "species_266074", "species_210382" ], "modifiers": [ [ "species_10517845", "catalyst" ] ], "additional_components": [ "A0A486WVP7", "WBGene00020590", "B5BM47", "WBGene00020590", "H2L0B7", "WBGene00020590", "O18256", "WBGene00020590", "Q9N5V4", "WBGene00020590" ] }, "reaction_10542985": { "compartment": "compartment_12045", "id": "reaction_10542985", "reactome": "R-CEL-2161745", "name": "20oh-LTB4 is oxidised to 20cho-LTB4 by CYP4F2/4F3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29368", "species_29364", "species_2161636" ], "products": [ "species_29356", "species_29366", "species_2142740" ], "modifiers": [ [ "species_10516925", "catalyst" ] ], "additional_components": [ "Q9XVA6", "WBGene00008499", "G5EC97", "WBGene00011830", "G5EGT6", "WBGene00010354", "O17851", "WBGene00009226", "O45219", "WBGene00007140", "Q09660", "WBGene00000375", "Q9N525", "WBGene00021412", "Q9N574", "WBGene00021200" ] }, "reaction_10517866": { "compartment": "compartment_70101", "id": "reaction_10517866", "reactome": "R-CEL-266072", "name": "LTA4 is hydolysed to LTB4 by LTA4H", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_265281" ], "products": [ "species_266056" ], "modifiers": [ [ "species_10517863", "catalyst" ] ], "additional_components": [ "species_216785", "G5EFT4", "WBGene00016589" ] }, "reaction_10542988": { "compartment": "compartment_12045", "id": "reaction_10542988", "reactome": "R-CEL-2161792", "name": "20cho-LTB4 is oxidised to 20cooh-LTB4 by CYP4F2/4F3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29368", "species_29364", "species_2142740" ], "products": [ "species_2161582", "species_29356", "species_29366" ], "modifiers": [ [ "species_10516925", "catalyst" ] ], "additional_components": [ "Q9XVA6", "WBGene00008499", "G5EC97", "WBGene00011830", "G5EGT6", "WBGene00010354", "O17851", "WBGene00009226", "O45219", "WBGene00007140", "Q09660", "WBGene00000375", "Q9N525", "WBGene00021412", "Q9N574", "WBGene00021200" ] }, "reaction_10543012": { "compartment": "compartment_70101", "id": "reaction_10543012", "reactome": "R-CEL-2161959", "name": "12R-HpETE is reduced to 12R-HETE by GPX1/2/4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29450", "species_2142790" ], "products": [ "species_29356", "species_2142716", "species_111745" ], "modifiers": [ [ "species_10543009", "catalyst" ] ], "additional_components": [ "WBGene00019846" ] }, "reaction_10543014": { "compartment": "compartment_70101", "id": "reaction_10543014", "reactome": "R-CEL-2161999", "name": "12S-HpETE is reduced to 12S-HETE by GPX1/2/4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2142811", "species_29450" ], "products": [ "species_29356", "species_2142678", "species_111745" ], "modifiers": [ [ "species_10543009", "catalyst" ] ], "additional_components": [ "WBGene00019846" ] }, "reaction_10557116": { "compartment": "compartment_13977", "id": "reaction_10557116", "reactome": "R-CEL-5693751", "name": "FAAH2 hydrolyses AEA to AA and ETA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5693752", "species_5693747" ], "products": [ "species_5693736", "species_5693733" ], "modifiers": [ [ "species_10557113", "catalyst" ] ], "additional_components": [ "WBGene00013164" ] }, "reaction_10506598": { "compartment": "compartment_5460", "id": "reaction_10506598", "reactome": "R-CEL-74181", "name": "acetoacetyl-CoA + CoA <=> 2 acetyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_73871" ], "products": [ "species_113559" ], "modifiers": [ [ "species_10503443", "catalyst" ] ], "additional_components": [ "Q22100", "WBGene00002183" ] }, "reaction_10506586": { "compartment": "compartment_5460", "id": "reaction_10506586", "reactome": "R-CEL-74177", "name": "OXCT dimers transfer CoA from SUCC-CoA to ACA, forming ACA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70958", "species_73909" ], "products": [ "species_73871", "species_113536" ], "modifiers": [ [ "species_10506583", "catalyst" ] ], "additional_components": [ "Q09450", "WBGene00007330" ] }, "reaction_10506419": { "compartment": "compartment_5460", "id": "reaction_10506419", "reactome": "R-CEL-73918", "name": "acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73871", "species_113559" ], "products": [ "species_29374", "species_73917" ], "modifiers": [ [ "species_10506416", "catalyst" ] ], "additional_components": [ "WBGene00017769" ] }, "reaction_10506596": { "compartment": "compartment_5460", "id": "reaction_10506596", "reactome": "R-CEL-74180", "name": "HMG CoA => acetoacetic acid + acetyl CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73917" ], "products": [ "species_113559", "species_73909" ], "modifiers": [ [ "species_10506593", "catalyst" ] ], "additional_components": [ "Q95XN1", "WBGene00022150" ] }, "reaction_10557499": { "compartment": "compartment_70101", "id": "reaction_10557499", "reactome": "R-CEL-5694494", "name": "AACS ligates CoA-SH to ACA, forming ACA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_76194", "species_29666" ], "products": [ "species_111294", "species_191293", "species_76577" ], "modifiers": [ [ "species_10557496", "catalyst" ] ], "additional_components": [ "WBGene00006351" ] }, "reaction_10558315": { "compartment": "compartment_70101", "id": "reaction_10558315", "reactome": "R-CEL-6788597", "name": "HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191374" ], "products": [ "species_76183", "species_29666" ], "modifiers": [ [ "species_10558312", "catalyst" ] ], "additional_components": [ "species_114632", "Q95XN1", "WBGene00022150" ] }, "reaction_10536353": { "compartment": "compartment_161320", "id": "reaction_10536353", "reactome": "R-CEL-1605624", "name": "Beta-galactosidase hydrolyses GM1 to GM2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_1605677" ], "products": [ "species_1605637", "species_1605610" ], "modifiers": [ [ "species_10536350", "catalyst" ] ], "additional_components": [ "WBGene00011832" ] }, "reaction_10536324": { "compartment": "compartment_17938", "id": "reaction_10536324", "reactome": "R-CEL-1605591", "name": "Glucosylceramidase cleaves the glucosidic bond of glucocerebroside to form ceramide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_1605592" ], "products": [ "species_1605745", "species_1605673" ], "modifiers": [ [ "species_10536321", "catalyst" ] ], "additional_components": [ "G5ECR8", "WBGene00008706", "Q18276", "WBGene00004995" ] }, "reaction_10536360": { "compartment": "compartment_161320", "id": "reaction_10536360", "reactome": "R-CEL-1605632", "name": "Both hexosaminidase A and B can cleave GalNAc from globoside", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_1605608" ], "products": [ "species_1605716", "species_1605658" ], "modifiers": [ [ "species_10536357", "catalyst" ] ], "additional_components": [ "Q22492", "WBGene00020509" ] }, "reaction_10536680": { "compartment": "compartment_876", "id": "reaction_10536680", "reactome": "R-CEL-1640164", "name": "Ectonucleotide pyrophosphatase/phosphodiesterase 7 (ENPP7) hydrolyses sphingomyelin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_429776" ], "products": [ "species_429807", "species_1610735" ], "modifiers": [ [ "species_10536677", "catalyst" ] ], "additional_components": [ "Q22129", "WBGene00020195", "O45359", "WBGene00020195", "Q17540", "WBGene00020195" ] }, "reaction_10537833": { "compartment": "compartment_876", "id": "reaction_10537833", "reactome": "R-CEL-1861788", "name": "Glucosylceramidase 2 cleaves the glucosidic bond of glucocerebroside to form ceramide (plasma membrane)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1861782" ], "products": [ "species_429807", "species_70113" ], "modifiers": [ [ "species_10537830", "catalyst" ] ], "additional_components": [ "WBGene00019965" ] }, "reaction_10536363": { "compartment": "compartment_161320", "id": "reaction_10536363", "reactome": "R-CEL-1605717", "name": "Ganglioside GM2 activator presents GM2 to hexosaminidase for cleavage", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10536329", "species_1605610" ], "products": [ "species_10536331" ], "modifiers": [ [ "species_10536329", "catalyst" ] ], "additional_components": [ "WBGene00021095", "species_1605610", "O02106", "WBGene00021095", "WBGene00021095" ] }, "reaction_10536427": { "compartment": "compartment_876", "id": "reaction_10536427", "reactome": "R-CEL-1606273", "name": "Sphingomyelin phosphodiesterase 2 and 3 (SMPD2 and 3) hydrolyse sphingomyelin to ceramide (plasma membrane)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_429776" ], "products": [ "species_429807", "species_1610735" ], "modifiers": [ [ "species_10536424", "catalyst" ] ], "additional_components": [ "O45870", "WBGene00012105", "species_114632" ] }, "reaction_10536459": { "compartment": "compartment_161320", "id": "reaction_10536459", "reactome": "R-CEL-1606602", "name": "Acid ceramidase hydrolyses ceramide into sphingosine and free fatty acid (lysosome)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_1605673" ], "products": [ "species_1861779", "species_1606588" ], "modifiers": [ [ "species_10536456", "catalyst" ] ], "additional_components": [ "O45686", "WBGene00010769" ] }, "reaction_10536652": { "compartment": "compartment_20699", "id": "reaction_10536652", "reactome": "R-CEL-1638104", "name": "Ceramide glucosyltransferase (UGCG) catalyses the transfer of glucose to ceramide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_744227", "species_428270" ], "products": [ "species_1660674", "species_205687" ], "modifiers": [ [ "species_10536649", "catalyst" ] ], "additional_components": [ "WBGene00017625" ] }, "reaction_10567887": { "compartment": "compartment_17963", "id": "reaction_10567887", "reactome": "R-CEL-8878914", "name": "B3GALNT1 transfer GalNAc to Gb3Cer to form Gb4Cer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_735700", "species_8879102" ], "products": [ "species_8879101", "species_205687" ], "modifiers": [ [ "species_10567884", "catalyst" ] ], "additional_components": [ "WBGene00000270" ] }, "reaction_10558126": { "compartment": "compartment_70101", "id": "reaction_10558126", "reactome": "R-CEL-6785933", "name": "UGT8 transfers Gal from UDP-Gal to CERA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29452", "species_429807" ], "products": [ "species_6785915", "species_110096" ], "modifiers": [ [ "species_10558123", "catalyst" ] ], "additional_components": [ "WBGene00012013" ] }, "reaction_10537842": { "compartment": "compartment_70101", "id": "reaction_10537842", "reactome": "R-CEL-1861789", "name": "Glucosylceramidase 3 cleaves the glucosidic bond of glucocerebroside to form ceramide (cytosol)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1861764" ], "products": [ "species_194377", "species_70113" ], "modifiers": [ [ "species_10537839", "catalyst" ] ], "additional_components": [ "Q18758", "WBGene00016848", "Q9TZA0", "WBGene00017103" ] }, "reaction_10551475": { "compartment": "compartment_70101", "id": "reaction_10551475", "reactome": "R-CEL-5339535", "name": "GLTPD1 transports C1P from plasma membrane to Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1638840" ], "products": [ "species_5339515" ], "modifiers": [ [ "species_10551472", "catalyst" ] ], "additional_components": [ "WBGene00018632" ] }, "reaction_10536660": { "compartment": "compartment_876", "id": "reaction_10536660", "reactome": "R-CEL-1638845", "name": "CERK phosphorylates CERA to form C1P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_429807", "species_113592" ], "products": [ "species_29370", "species_1638840" ], "modifiers": [ [ "species_10536657", "catalyst" ] ], "additional_components": [ "WBGene00020398" ] }, "reaction_10536373": { "compartment": "compartment_161320", "id": "reaction_10536373", "reactome": "R-CEL-1605736", "name": "Alpha-galactosidase A removes a terminal galactose from alpha-D-galactoside oligomers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605716", "species_1605715" ], "products": [ "species_1605637", "species_1605601" ], "modifiers": [ [ "species_10536370", "catalyst" ] ], "additional_components": [ "Q21801", "WBGene00011095" ] }, "reaction_10536437": { "compartment": "compartment_17957", "id": "reaction_10536437", "reactome": "R-CEL-1606288", "name": "Sphingomyelin phosphodiesterase 4 (SMPD4) hydrolyses sphingomyelin to ceramide (ER membrane)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113519", "species_1606283" ], "products": [ "species_428256", "species_1606280" ], "modifiers": [ [ "species_10536434", "catalyst" ] ], "additional_components": [ "Q95ZR2", "WBGene00011037", "species_114632" ] }, "reaction_10536439": { "compartment": "compartment_161320", "id": "reaction_10536439", "reactome": "R-CEL-1606312", "name": "Beta-galactosidase can also hydrolyse globosides to form cerebrosides", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_1605601" ], "products": [ "species_1605637", "species_1605592" ], "modifiers": [ [ "species_10536350", "catalyst" ] ], "additional_components": [ "WBGene00011832" ] }, "reaction_10536345": { "compartment": "compartment_161320", "id": "reaction_10536345", "reactome": "R-CEL-1605595", "name": "Hexosaminidase A cleaves GalNAc from GM2 to form GM3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_10536331" ], "products": [ "species_10536329", "species_1605658", "species_1605641" ], "modifiers": [ [ "species_10536342", "catalyst" ] ], "additional_components": [ "species_1605610", "O02106", "WBGene00021095", "WBGene00021095", "Q22492", "WBGene00020509" ] }, "reaction_10536381": { "compartment": "compartment_161320", "id": "reaction_10536381", "reactome": "R-CEL-1605797", "name": "Sphingomyelin phosphodiesterase (SMPD1) hydrolyses sphingomyelin to ceramide (lysosome)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_1605713" ], "products": [ "species_1605750", "species_1605673" ], "modifiers": [ [ "species_10536378", "catalyst" ] ], "additional_components": [ "WBGene00000212" ] }, "reaction_10551516": { "compartment": "compartment_876", "id": "reaction_10551516", "reactome": "R-CEL-5340320", "name": "GLTP transports GSL from plasma membrane to ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5340315" ], "products": [ "species_5340299" ], "modifiers": [ [ "species_10551513", "catalyst" ] ], "additional_components": [ "WBGene00022347" ] }, "reaction_10565820": { "compartment": "compartment_12045", "id": "reaction_10565820", "reactome": "R-CEL-8857662", "name": "ESYT1:ESYT2:ESYT3 transport GPL from plasma membrane to ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8857646" ], "products": [ "species_8857684" ], "modifiers": [ [ "species_10565817", "catalyst" ], [ "species_74016", "catalyst" ] ], "additional_components": [ "A0A679L8R0", "WBGene00020443" ] }, "reaction_10536447": { "compartment": "compartment_161320", "id": "reaction_10536447", "reactome": "R-CEL-1606564", "name": "Galactocerebrosidase cleaves the galactosyl bond of galactocerebroside to form ceramide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_1606573" ], "products": [ "species_1605745", "species_1605673" ], "modifiers": [ [ "species_10536444", "catalyst" ] ], "additional_components": [ "WBGene00016207" ] }, "reaction_10523456": { "compartment": "compartment_70101", "id": "reaction_10523456", "reactome": "R-CEL-429698", "name": "PRKD1,2,3 phosphorylates COL4A3BP-2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10523428" ], "products": [ "species_29370", "species_10523431" ], "modifiers": [ [ "species_10523453", "catalyst" ] ], "additional_components": [ "WBGene00009120", "WBGene00009120", "Q9XUJ7", "WBGene00012352", "O45818", "WBGene00012019" ] }, "reaction_10556864": { "compartment": "compartment_12045", "id": "reaction_10556864", "reactome": "R-CEL-5692261", "name": "ALDH3A2-1 oxidises HD2NAL to PALM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_428671", "species_29360" ], "products": [ "species_70106", "species_3632881", "species_73473" ], "modifiers": [ [ "species_10556861", "catalyst" ] ], "additional_components": [ "A0A486WWU7", "WBGene00000110", "O44555", "WBGene00000111" ] }, "reaction_10523106": { "compartment": "compartment_70101", "id": "reaction_10523106", "reactome": "R-CEL-428214", "name": "sphinganine (dihydrosphingosine) +ATP => sphinganine 1-phosphate + ADP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_428163" ], "products": [ "species_29370", "species_428275" ], "modifiers": [ [ "species_10520872", "catalyst" ] ], "additional_components": [ "WBGene00007918" ] }, "reaction_10570149": { "compartment": "compartment_12045", "id": "reaction_10570149", "reactome": "R-CEL-8959462", "name": "SAMD8 transforms PE and CERA to CPE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8959490", "species_8959486" ], "products": [ "species_8959463" ], "modifiers": [ [ "species_10570146", "catalyst" ] ], "additional_components": [ "WBGene00018735" ] }, "reaction_10557124": { "compartment": "compartment_12045", "id": "reaction_10557124", "reactome": "R-CEL-5693761", "name": "FA2H hydroxylates CERA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_428256" ], "products": [ "species_5693768", "species_29356" ], "modifiers": [ [ "species_10557121", "catalyst" ] ], "additional_components": [ "WBGene00007707" ] }, "reaction_10523111": { "compartment": "compartment_70101", "id": "reaction_10523111", "reactome": "R-CEL-428231", "name": "ceramide + H2O <=> stearate + sphingosine [endoplasmic reticulum]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_428256" ], "products": [ "species_428193", "species_428198" ], "modifiers": [ [ "species_10523108", "catalyst" ] ], "additional_components": [ "WBGene00020947" ] }, "reaction_10523207": { "compartment": "compartment_70101", "id": "reaction_10523207", "reactome": "R-CEL-428676", "name": "sphingosine 1-phosphate => phosphoethanolamine + hexadec-2-enal", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428203" ], "products": [ "species_428671", "species_428686" ], "modifiers": [ [ "species_10523204", "catalyst" ] ], "additional_components": [ "WBGene00004981" ] }, "reaction_10563430": { "compartment": "compartment_13977", "id": "reaction_10563430", "reactome": "R-CEL-6808464", "name": "ALDH3B2 oxidises HXAL to PALM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_6808468", "species_29360" ], "products": [ "species_2453691", "species_70106", "species_73473" ], "modifiers": [ [ "species_10563427", "catalyst" ] ], "additional_components": [ "O44555", "WBGene00000111", "A0A486WWU7", "WBGene00000110" ] }, "reaction_10523209": { "compartment": "compartment_70101", "id": "reaction_10523209", "reactome": "R-CEL-428681", "name": "sphinganine 1-phosphate => phosphoethanolamine + hexadecanal", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428275" ], "products": [ "species_428686", "species_428663" ], "modifiers": [ [ "species_10523204", "catalyst" ] ], "additional_components": [ "WBGene00004981" ] }, "reaction_10523051": { "compartment": "compartment_70101", "id": "reaction_10523051", "reactome": "R-CEL-428123", "name": "3-ketosphinganine + NADPH + H+ => sphinganine + NADP+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_428182" ], "products": [ "species_29366", "species_428163" ], "modifiers": [ [ "species_10523048", "catalyst" ] ], "additional_components": [ "WBGene00021367" ] }, "reaction_10523468": { "compartment": "compartment_70101", "id": "reaction_10523468", "reactome": "R-CEL-429714", "name": "monophospho-CERT + 2 ATP => multiphospho-CERT + 2 ADP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10523431" ], "products": [ "species_29370", "species_10523460" ], "modifiers": [ [ "species_10523465", "catalyst" ] ], "additional_components": [ "WBGene00009120", "WBGene00009120", "WBGene00013709" ] }, "reaction_10523217": { "compartment": "compartment_984", "id": "reaction_10523217", "reactome": "R-CEL-428690", "name": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [extracellular]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_419305", "species_109276" ], "products": [ "species_109277", "species_428662" ], "modifiers": [ [ "species_10523214", "catalyst" ] ], "additional_components": [ "WBGene00018756" ] }, "reaction_10523251": { "compartment": "compartment_70101", "id": "reaction_10523251", "reactome": "R-CEL-428696", "name": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - PPAP]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428203", "species_29356" ], "products": [ "species_428682", "species_29372" ], "modifiers": [ [ "species_10523248", "catalyst" ] ], "additional_components": [ "Q22250", "WBGene00011524", "H2KZD1", "WBGene00018756", "Q10022", "WBGene00020895", "Q19403", "WBGene00008749" ] }, "reaction_10573237": { "compartment": "compartment_70101", "id": "reaction_10573237", "reactome": "R-CEL-9695890", "name": "SPNS2 transports S1P from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428203" ], "products": [ "species_419305" ], "modifiers": [ [ "species_10573234", "catalyst" ] ], "additional_components": [ "A0A3B1DV80", "WBGene00013739", "Q19235", "WBGene00008598", "O01927", "WBGene00007549", "Q18545", "WBGene00008033" ] }, "reaction_10523509": { "compartment": "compartment_876", "id": "reaction_10523509", "reactome": "R-CEL-429786", "name": "phosphatidylcholine + ceramide <=> sphingomyelin + diacylglycerol [SGMS2]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_429802", "species_429807" ], "products": [ "species_429776", "species_112275" ], "modifiers": [ [ "species_10523506", "catalyst" ] ], "additional_components": [ "Q9U3D4", "WBGene00004892", "Q965Q4", "WBGene00004894", "Q9TYV2", "WBGene00021075", "Q20735", "WBGene00004893" ] }, "reaction_10523093": { "compartment": "compartment_70101", "id": "reaction_10523093", "reactome": "R-CEL-428185", "name": "sphinganine + stearyl-CoA => dihydroceramide + CoASH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428139", "species_428163" ], "products": [ "species_428126", "species_76194" ], "modifiers": [ [ "species_10523090", "catalyst" ] ], "additional_components": [ "Q9XWE9", "WBGene00006505", "G5ED45", "WBGene00002043", "Q7Z139", "WBGene00002044" ] }, "reaction_10523126": { "compartment": "compartment_70101", "id": "reaction_10523126", "reactome": "R-CEL-428259", "name": "dihydroceramide + NAD(P)H + H+ + O2 => ceramide + NAD(P)+ + H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_428206", "species_428126", "species_29368" ], "products": [ "species_428218", "species_29356", "species_428256" ], "modifiers": [ [ "species_10523123", "catalyst" ] ], "additional_components": [ "species_73473", "species_29364", "species_29360", "species_29366", "O44186", "WBGene00017996", "G5EC63", "WBGene00013197" ] }, "reaction_10557561": { "compartment": "compartment_876", "id": "reaction_10557561", "reactome": "R-CEL-5696080", "name": "ALDH3B1 oxidises HXAL to PALM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_428663", "species_29360" ], "products": [ "species_70106", "species_3632881", "species_73473" ], "modifiers": [ [ "species_10557558", "catalyst" ] ], "additional_components": [ "A0A486WWU7", "WBGene00000110", "O44555", "WBGene00000111" ] }, "reaction_10523129": { "compartment": "compartment_70101", "id": "reaction_10523129", "reactome": "R-CEL-428260", "name": "dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_428126", "species_29368", "species_29364" ], "products": [ "species_29356", "species_29366", "species_9025544" ], "modifiers": [ [ "species_10523123", "catalyst" ] ], "additional_components": [ "O44186", "WBGene00017996", "G5EC63", "WBGene00013197" ] }, "reaction_10523514": { "compartment": "compartment_20699", "id": "reaction_10523514", "reactome": "R-CEL-429798", "name": "phosphatidylcholine + ceramide <=> sphingomyelin + diacylglycerol [SGMS1]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_429785", "species_428270" ], "products": [ "species_429773", "species_429789" ], "modifiers": [ [ "species_10523511", "catalyst" ] ], "additional_components": [ "WBGene00004892" ] }, "reaction_10573242": { "compartment": "compartment_70101", "id": "reaction_10573242", "reactome": "R-CEL-9695949", "name": "SPHK2 phosphorylates SPG to S1P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_428193" ], "products": [ "species_428203", "species_29370" ], "modifiers": [ [ "species_10523103", "catalyst" ], [ "species_10573240", "inhibitor" ] ], "additional_components": [ "WBGene00007918", "Q18425", "WBGene00007918" ] }, "reaction_10523132": { "compartment": "compartment_70101", "id": "reaction_10523132", "reactome": "R-CEL-428273", "name": "SPHK1 phosphorylates SPG to S1P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_428193" ], "products": [ "species_428203", "species_29370" ], "modifiers": [ [ "species_10520872", "catalyst" ] ], "additional_components": [ "WBGene00007918" ] }, "reaction_10523101": { "compartment": "compartment_20699", "id": "reaction_10523101", "reactome": "R-CEL-428205", "name": "ceramide + H2O => stearate + sphingosine [Golgi]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_428270" ], "products": [ "species_428248", "species_8934421" ], "modifiers": [ [ "species_10523098", "catalyst" ] ], "additional_components": [ "WBGene00020947" ] }, "reaction_10536978": { "compartment": "compartment_20699", "id": "reaction_10536978", "reactome": "R-CEL-1655851", "name": "S2P hydrolyzes SREBP1A,1C,2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10536972" ], "products": [ "species_10536935" ], "modifiers": [ [ "species_10522008", "catalyst" ] ], "additional_components": [ "WBGene00004735", "WBGene00004735", "WBGene00013225" ] }, "reaction_10542407": { "compartment": "compartment_7660", "id": "reaction_10542407", "reactome": "R-CEL-2065539", "name": "SREBP1A,1C,2:Importin beta-1 dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10536955", "species_10542403" ], "products": [ "species_10536951", "species_10542405" ], "modifiers": [], "additional_components": [ "Q9XX00", "WBGene00004735", "Q9BIB8", "WBGene00002075", "O17915", "WBGene00004302", "species_29438", "Q9XX00", "WBGene00004735", "O17915", "WBGene00004302", "species_29438", "Q9BIB8", "WBGene00002075" ] }, "reaction_10542409": { "compartment": "compartment_70101", "id": "reaction_10542409", "reactome": "R-CEL-2065549", "name": "SREBP1A,1C,2 binds SREBP1A,1C,2 forming dimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10536935" ], "products": [ "species_10536941" ], "modifiers": [], "additional_components": [ "WBGene00004735", "Q9XX00", "WBGene00004735" ] }, "reaction_10542411": { "compartment": "compartment_70101", "id": "reaction_10542411", "reactome": "R-CEL-2065550", "name": "SREBP1A,1C,2 binds Importin beta-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10536941", "species_10516892" ], "products": [ "species_10536943" ], "modifiers": [], "additional_components": [ "Q9XX00", "WBGene00004735", "WBGene00002075", "Q9BIB8", "WBGene00002075", "Q9XX00", "WBGene00004735" ] }, "reaction_10536957": { "compartment": "compartment_70101", "id": "reaction_10536957", "reactome": "R-CEL-1655831", "name": "SREBP1A,1C,2 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10536943" ], "products": [ "species_10536955" ], "modifiers": [], "additional_components": [ "Q9BIB8", "WBGene00002075", "Q9XX00", "WBGene00004735", "Q9XX00", "WBGene00004735", "Q9BIB8", "WBGene00002075" ] }, "reaction_10557203": { "compartment": "compartment_12045", "id": "reaction_10557203", "reactome": "R-CEL-5694077", "name": "EPHX1 hydrates BaP4,5O to BaP4,5-DHD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_5694080" ], "products": [ "species_5694091" ], "modifiers": [ [ "species_10557200", "catalyst" ] ], "additional_components": [ "WBGene00020909" ] }, "reaction_10568323": { "compartment": "compartment_70101", "id": "reaction_10568323", "reactome": "R-CEL-8937442", "name": "CES3 hydrolyses CHEST to CHOL and LCFA(-)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_163579" ], "products": [ "species_8876730", "species_216762" ], "modifiers": [ [ "species_10568320", "catalyst" ] ], "additional_components": [ "O01302", "WBGene00011362", "P92016", "WBGene00011364", "Q04457", "WBGene00001578", "Q21266", "WBGene00019477", "A0A1C3NSL8", "WBGene00017478", "Q22008", "WBGene00020125", "G5EDJ7", "WBGene00013875", "Q23268", "WBGene00013873", "H2L0K7", "WBGene00020330", "Q4LDP0", "WBGene00020891", "H9G2Y9", "WBGene00013874", "Q9XW75", "WBGene00013540" ] }, "reaction_10517444": { "compartment": "compartment_17960", "id": "reaction_10517444", "reactome": "R-CEL-217255", "name": "FMO1:FAD N-oxidises TAM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_113601", "species_159154" ], "products": [ "species_113519", "species_113564", "species_217269" ], "modifiers": [ [ "species_10517441", "catalyst" ] ], "additional_components": [ "species_113596", "G5EBJ9", "WBGene00001477", "G5ECJ8", "WBGene00001478", "G5ED43", "WBGene00001480", "G5EDG8", "WBGene00001479", "G5EDP6", "WBGene00001476" ] }, "reaction_10517461": { "compartment": "compartment_17960", "id": "reaction_10517461", "reactome": "R-CEL-217258", "name": "FMO2:FAD:Mg2+ S-oxidises MTZ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_113601", "species_217315" ], "products": [ "species_113519", "species_113564", "species_217320" ], "modifiers": [ [ "species_10517458", "catalyst" ] ], "additional_components": [ "G5EBJ9", "WBGene00001477", "G5ECJ8", "WBGene00001478", "G5ED43", "WBGene00001480", "G5EDG8", "WBGene00001479", "G5EDP6", "WBGene00001476", "species_114632", "species_113596" ] }, "reaction_10509718": { "compartment": "compartment_17957", "id": "reaction_10509718", "reactome": "R-CEL-139970", "name": "FMO3:FAD N-oxidises TMA to TMAO", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_30373", "species_113601" ], "products": [ "species_113519", "species_113564", "species_140963" ], "modifiers": [ [ "species_10509715", "catalyst" ] ], "additional_components": [ "G5ECJ8", "WBGene00001478", "G5ED43", "WBGene00001480", "G5EDG8", "WBGene00001479", "G5EBJ9", "WBGene00001477", "G5EDP6", "WBGene00001476", "species_113596" ] }, "reaction_10504257": { "compartment": "compartment_70101", "id": "reaction_10504257", "reactome": "R-CEL-71707", "name": "ethanol + NAD+ => acetaldehyde + NADH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30203", "species_29360" ], "products": [ "species_70106", "species_29510", "species_73473" ], "modifiers": [ [ "species_10504254", "catalyst" ] ], "additional_components": [ "species_216785", "Q17335", "WBGene00019240" ] }, "reaction_10557573": { "compartment": "compartment_5460", "id": "reaction_10557573", "reactome": "R-CEL-5696091", "name": "ALDH1B1 tetramer oxidises CH3CHO to CH3COOH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113532", "species_113526", "species_113521" ], "products": [ "species_113529", "species_29362", "species_113539" ], "modifiers": [ [ "species_10557570", "catalyst" ] ], "additional_components": [ "Q20780", "WBGene00000107", "Q9TXM0", "WBGene00000108" ] }, "reaction_10556853": { "compartment": "compartment_70101", "id": "reaction_10556853", "reactome": "R-CEL-5692237", "name": "ADH5 oxidises S-HMGSH to S-FGSH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5692221", "species_29360" ], "products": [ "species_5692249", "species_70106", "species_73473" ], "modifiers": [ [ "species_10556850", "catalyst" ] ], "additional_components": [ "species_216785", "Q17335", "WBGene00019240" ] }, "reaction_10504267": { "compartment": "compartment_5460", "id": "reaction_10504267", "reactome": "R-CEL-71723", "name": "acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113532", "species_113526", "species_113521" ], "products": [ "species_113529", "species_29362", "species_113539" ], "modifiers": [ [ "species_10504264", "catalyst" ] ], "additional_components": [ "Q20780", "WBGene00000107" ] }, "reaction_10504285": { "compartment": "compartment_70101", "id": "reaction_10504285", "reactome": "R-CEL-71735", "name": "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_29416", "species_76194" ], "products": [ "species_111294", "species_76183", "species_76577" ], "modifiers": [ [ "species_10504282", "catalyst" ] ], "additional_components": [ "WBGene00007969" ] }, "reaction_10557063": { "compartment": "compartment_17957", "id": "reaction_10557063", "reactome": "R-CEL-5693691", "name": "CES1 trimer.CES2 hydrolyse COCN to BEG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113519", "species_5693702" ], "products": [ "species_156540", "species_5693711", "species_5693712" ], "modifiers": [ [ "species_10557060", "catalyst" ] ], "additional_components": [ "H9G2Y9", "WBGene00013874", "Q9XW75", "WBGene00013540", "O01302", "WBGene00011362", "P92016", "WBGene00011364", "Q04457", "WBGene00001578", "Q21266", "WBGene00019477", "A0A1C3NSL8", "WBGene00017478", "Q22008", "WBGene00020125", "G5EDJ7", "WBGene00013875", "Q23268", "WBGene00013873", "H2L0K7", "WBGene00020330", "Q4LDP0", "WBGene00020891" ] }, "reaction_10556121": { "compartment": "compartment_12045", "id": "reaction_10556121", "reactome": "R-CEL-5689000", "name": "AADAC deacetylates PHEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_5689006" ], "products": [ "species_5689001", "species_5688995" ], "modifiers": [ [ "species_10556118", "catalyst" ] ], "additional_components": [ "Q19839", "WBGene00009186", "Q9XWL5", "WBGene00012810", "Q7JMM5", "WBGene00017515", "Q94187", "WBGene00017515" ] }, "reaction_10558105": { "compartment": "compartment_70101", "id": "reaction_10558105", "reactome": "R-CEL-6784959", "name": "BPHL hydrolyses VACV to ACV", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_6784964" ], "products": [ "species_29702", "species_561052" ], "modifiers": [ [ "species_10558102", "catalyst" ] ], "additional_components": [ "WBGene00019280" ] }, "reaction_10556888": { "compartment": "compartment_70101", "id": "reaction_10556888", "reactome": "R-CEL-5692283", "name": "ALD3A1 oxidises 4HPCP to CXPA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5692409", "species_29356", "species_29366" ], "products": [ "species_70106", "species_5692433", "species_29364" ], "modifiers": [ [ "species_10556870", "catalyst" ], [ "species_10556882", "catalyst" ], [ "species_10556886", "inhibitor" ] ], "additional_components": [ "A0A486WWU7", "WBGene00000110", "O44555", "WBGene00000111", "O02219", "WBGene00000095", "species_8936852", "O44712", "WBGene00000096", "O44712", "WBGene00000096", "O02219", "WBGene00000095" ] }, "reaction_10568168": { "compartment": "compartment_70101", "id": "reaction_10568168", "reactome": "R-CEL-8936442", "name": "MARC1,MARC2 reduce N-hydroxylated compounds", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_8936443", "species_73473" ], "products": [ "species_29356", "species_29468", "species_29360" ], "modifiers": [ [ "species_10568165", "catalyst" ] ], "additional_components": [ "CHEBI:21437", "U4PC34", "WBGene00018925", "Q93315", "WBGene00007848", "O16521", "WBGene00020268", "P91321", "WBGene00018925", "O45394", "WBGene00018925" ] }, "reaction_10544101": { "compartment": "compartment_5460", "id": "reaction_10544101", "reactome": "R-CEL-2395512", "name": "FDXR transfers electrons to FDX1,2 (FDX1L)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10533041", "species_10544097" ], "products": [ "species_10533037", "species_113529", "species_10544099" ], "modifiers": [], "additional_components": [ "CHEBI:33737", "Q9NA32", "WBGene00013532", "species_31649", "Q9U1X0", "WBGene00013376", "CHEBI:33738", "Q9NA32", "WBGene00013532", "species_113596", "Q9U1X0", "WBGene00013376" ] }, "reaction_10544103": { "compartment": "compartment_5460", "id": "reaction_10544103", "reactome": "R-CEL-2395517", "name": "NADPH transfers electrons to FDXR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113529", "species_10544099", "species_113600" ], "products": [ "species_113563", "species_10544097" ], "modifiers": [], "additional_components": [ "species_113596", "Q9U1X0", "WBGene00013376", "species_31649", "Q9U1X0", "WBGene00013376" ] }, "reaction_10533044": { "compartment": "compartment_5460", "id": "reaction_10533044", "reactome": "R-CEL-1362408", "name": "FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10533037", "species_379721", "species_10533030" ], "products": [ "species_10533039", "species_379697", "species_10533041" ], "modifiers": [ [ "species_10533030", "catalyst" ], [ "species_10533037", "catalyst" ] ], "additional_components": [ "CHEBI:33738", "Q9NA32", "WBGene00013532", "Q9TY03", "WBGene00001486", "species_113531", "O61741", "WBGene00015021", "O45948", "WBGene00012885", "A0A2R8F5A8", "WBGene00302998", "Q9TY03", "WBGene00001486", "O61741", "WBGene00015021", "O45948", "WBGene00012885", "A0A2R8F5A8", "WBGene00302998", "CHEBI:33739", "CHEBI:33737", "Q9NA32", "WBGene00013532", "Q9TY03", "WBGene00001486", "species_113531", "O61741", "WBGene00015021", "O45948", "WBGene00012885", "A0A2R8F5A8", "WBGene00302998", "CHEBI:33738", "Q9NA32", "WBGene00013532" ] }, "reaction_10567878": { "compartment": "compartment_5460", "id": "reaction_10567878", "reactome": "R-CEL-8878815", "name": "Formation of 4Fe-4S cluster on ISCA1:ISCA2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10567869", "species_10567857" ], "products": [ "species_10567855", "species_10567871" ], "modifiers": [ [ "species_10567876", "catalyst" ] ], "additional_components": [ "A5HWB2", "WBGene00012666", "Q9XVZ9", "WBGene00013218", "CHEBI:33739", "Q9XTU9", "WBGene00013029", "WBGene00013029", "CHEBI:49883", "A5HWB2", "WBGene00012666", "Q9XVZ9", "WBGene00013218", "WBGene00001033" ] }, "reaction_10533049": { "compartment": "compartment_5460", "id": "reaction_10533049", "reactome": "R-CEL-1362416", "name": "Frataxin binds iron", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113531", "species_10533047" ], "products": [ "species_10533030" ], "modifiers": [], "additional_components": [ "Q9TY03", "WBGene00001486", "O61741", "WBGene00015021", "O45948", "WBGene00012885", "A0A2R8F5A8", "WBGene00302998", "Q9TY03", "WBGene00001486", "species_113531", "O61741", "WBGene00015021", "O45948", "WBGene00012885", "A0A2R8F5A8", "WBGene00302998" ] }, "reaction_10554321": { "compartment": "compartment_17963", "id": "reaction_10554321", "reactome": "R-CEL-5653873", "name": "SLC2A1 tetramer transports Glc from cytosol to Golgi lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70113" ], "products": [ "species_964746" ], "modifiers": [ [ "species_10554318", "catalyst" ] ], "additional_components": [ "Q21381", "WBGene00043980", "Q21382", "WBGene00043980", "Q21385", "WBGene00043980", "Q5WRR9", "WBGene00043980", "Q9GYQ1", "WBGene00043980", "Q9NEI8", "WBGene00043980" ] }, "reaction_10562084": { "compartment": "compartment_70101", "id": "reaction_10562084", "reactome": "R-CEL-6799495", "name": "GLYCTK phosphorylates DGA to 3PDGA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6799497", "species_113592" ], "products": [ "species_70106", "species_29370", "species_6799493" ], "modifiers": [ [ "species_10562081", "catalyst" ] ], "additional_components": [ "WBGene00015733" ] }, "reaction_10502888": { "compartment": "compartment_70101", "id": "reaction_10502888", "reactome": "R-CEL-70349", "name": "DAK dimer phosphorylates D-glyceraldehyde to form D-glyceraldehyde 3-phosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30393", "species_113592" ], "products": [ "species_29578", "species_29370" ], "modifiers": [ [ "species_10502885", "catalyst" ] ], "additional_components": [ "Q9N5C4", "WBGene00020962", "species_114632" ] }, "reaction_10502878": { "compartment": "compartment_70101", "id": "reaction_10502878", "reactome": "R-CEL-70342", "name": "ALDOB tetramer cleaves Fru-1-P to GA and DHAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_31221" ], "products": [ "species_30393", "species_75970" ], "modifiers": [ [ "species_10502875", "catalyst" ] ], "additional_components": [ "P54216", "WBGene00011474" ] }, "reaction_10554242": { "compartment": "compartment_70101", "id": "reaction_10554242", "reactome": "R-CEL-5652172", "name": "AKR1B1 reduces Glc to D-sorbitol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_70113" ], "products": [ "species_29366", "species_5652213" ], "modifiers": [ [ "species_10513654", "catalyst" ] ], "additional_components": [ "WBGene00016985" ] }, "reaction_10554254": { "compartment": "compartment_70101", "id": "reaction_10554254", "reactome": "R-CEL-5652195", "name": "SORD oxidizes D-sorbitol to Fru", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5652213", "species_29360" ], "products": [ "species_29532", "species_70106", "species_73473" ], "modifiers": [ [ "species_10554251", "catalyst" ] ], "additional_components": [ "species_216785", "Q21702", "WBGene00011003" ] }, "reaction_10502896": { "compartment": "compartment_70101", "id": "reaction_10502896", "reactome": "R-CEL-70361", "name": "GALT transfers UMP from UDP-Glc to Gal1P to form UDP-Gal", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30170", "species_29410" ], "products": [ "species_29452", "species_29548" ], "modifiers": [ [ "species_10502893", "catalyst" ] ], "additional_components": [ "WBGene00014203" ] }, "reaction_10502906": { "compartment": "compartment_70101", "id": "reaction_10502906", "reactome": "R-CEL-70369", "name": "GALE:NAD+ dimer reversibly epimerises UDP-Gal to UDP-Glc", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29452" ], "products": [ "species_29410" ], "modifiers": [ [ "species_10502903", "catalyst" ] ], "additional_components": [ "species_29360", "Q564Q1", "WBGene00008132" ] }, "reaction_10504192": { "compartment": "compartment_70101", "id": "reaction_10504192", "reactome": "R-CEL-71593", "name": "((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)glycogenin => poly{(1,4)-alpha-glucosyl} glycogenin + alpha-D-glucose", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10504148" ], "products": [ "species_10504189", "species_70113" ], "modifiers": [ [ "species_10504153", "catalyst" ] ], "additional_components": [ "G5ECZ5", "WBGene00011684", "H2KYQ5", "WBGene00006863", "O45819", "WBGene00012020", "species_266099", "G5ECZ5", "WBGene00011684", "H2KYQ5", "WBGene00006863", "O45819", "WBGene00012020", "species_266099", "WBGene00011050" ] }, "reaction_10526209": { "compartment": "compartment_70101", "id": "reaction_10526209", "reactome": "R-CEL-453342", "name": "PGYM dimer, b form + 2 AMP <=> PGYM b dimer:AMP complex", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10504012", "species_76577" ], "products": [ "species_10526195" ], "modifiers": [ [ "species_113592", "inhibitor" ], [ "species_30537", "inhibitor" ] ], "additional_components": [ "Q9N5U1", "WBGene00020696", "species_76577", "Q9N5U1", "WBGene00020696" ] }, "reaction_10504099": { "compartment": "compartment_70101", "id": "reaction_10504099", "reactome": "R-CEL-71541", "name": "glycogen phosphorylase (PYGM) dimer b + 2 ATP => glycogen phosphorylase (PYGM) dimer a + 2 ADP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10504012", "species_113592" ], "products": [ "species_29370", "species_10504017" ], "modifiers": [ [ "species_10504096", "catalyst" ], [ "species_74016", "catalyst" ] ], "additional_components": [ "Q9N5U1", "WBGene00020696", "Q9N5U1", "WBGene00020696", "Q9N3L4", "WBGene00021753", "P34335", "WBGene00015754", "H2L0I6", "WBGene00022059", "Q11083", "WBGene00020378", "P04630", "WBGene00000285", "G5EF37", "WBGene00003934", "A0A2C9C3L3", "WBGene00020378", "Q18136", "WBGene00006861", "Q09665", "WBGene00006583", "O02159", "WBGene00020378", "G5EDZ8", "WBGene00000288", "Q94288", "WBGene00000287", "Q09980", "WBGene00017394", "O16305", "WBGene00000552", "G5EEG0", "WBGene00000286" ] }, "reaction_10504156": { "compartment": "compartment_70101", "id": "reaction_10504156", "reactome": "R-CEL-71552", "name": "limit dextrin-glycogenin => ((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl) glycogenin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10504128" ], "products": [ "species_10504148" ], "modifiers": [ [ "species_10504153", "catalyst" ] ], "additional_components": [ "H2KYQ5", "WBGene00006863", "species_266099", "G5ECZ5", "WBGene00011684", "O45819", "WBGene00012020", "G5ECZ5", "WBGene00011684", "H2KYQ5", "WBGene00006863", "O45819", "WBGene00012020", "species_266099", "WBGene00011050" ] }, "reaction_10503904": { "compartment": "compartment_70101", "id": "reaction_10503904", "reactome": "R-CEL-71299", "name": "6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29996", "species_29366" ], "products": [ "species_70106", "species_113528", "species_29364", "species_29732" ], "modifiers": [ [ "species_10503901", "catalyst" ] ], "additional_components": [ "Q17761", "WBGene00012015" ] }, "reaction_10570503": { "compartment": "compartment_70101", "id": "reaction_10570503", "reactome": "R-CEL-8982667", "name": "PGM2:Mg2+ isomerises dR1P to dR5P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6787326" ], "products": [ "species_6787328" ], "modifiers": [ [ "species_10502849", "catalyst" ] ], "additional_components": [ "species_114632", "O45934", "WBGene00012803" ] }, "reaction_10569995": { "compartment": "compartment_70101", "id": "reaction_10569995", "reactome": "R-CEL-8955844", "name": "RBKS phosphorylates ribose to R5P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_8955853" ], "products": [ "species_73578", "species_29370" ], "modifiers": [ [ "species_10569992", "catalyst" ] ], "additional_components": [ "WBGene00008548" ] }, "reaction_10558222": { "compartment": "compartment_70101", "id": "reaction_10558222", "reactome": "R-CEL-6787321", "name": "DERA cleaves dR5P to GA3P and CH3CHO", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6787328" ], "products": [ "species_29578", "species_29510" ], "modifiers": [ [ "species_10558219", "catalyst" ] ], "additional_components": [ "WBGene00017283" ] }, "reaction_10558225": { "compartment": "compartment_70101", "id": "reaction_10558225", "reactome": "R-CEL-6787329", "name": "PGM2:Mg2+ isomerises R1P to R5P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_112016" ], "products": [ "species_73578" ], "modifiers": [ [ "species_10502849", "catalyst" ] ], "additional_components": [ "species_114632", "O45934", "WBGene00012803" ] }, "reaction_10503924": { "compartment": "compartment_70101", "id": "reaction_10503924", "reactome": "R-CEL-71303", "name": "RPE dimers isomerise RU5P to XY5P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29732" ], "products": [ "species_29790" ], "modifiers": [ [ "species_10503921", "catalyst" ] ], "additional_components": [ "Q95ZW2", "WBGene00017272", "species_113531" ] }, "reaction_10506066": { "compartment": "compartment_70101", "id": "reaction_10506066", "reactome": "R-CEL-73580", "name": "D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73578", "species_113592" ], "products": [ "species_73566", "species_76577" ], "modifiers": [ [ "species_10506063", "catalyst" ] ], "additional_components": [ "Q6AHR3", "WBGene00020107" ] }, "reaction_10508824": { "compartment": "compartment_70101", "id": "reaction_10508824", "reactome": "R-CEL-111215", "name": "D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73578", "species_110644" ], "products": [ "species_73566", "species_109386" ], "modifiers": [ [ "species_10506063", "catalyst" ], [ "species_29926", "catalyst" ], [ "species_29372", "catalyst" ] ], "additional_components": [ "Q6AHR3", "WBGene00020107" ] }, "reaction_10512117": { "compartment": "compartment_70101", "id": "reaction_10512117", "reactome": "R-CEL-177784", "name": "ribose 5-phosphate <=> D-ribulose 5-phosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73578" ], "products": [ "species_29732" ], "modifiers": [ [ "species_10503929", "catalyst" ] ], "additional_components": [ "WBGene00015101" ] }, "reaction_10503894": { "compartment": "compartment_70101", "id": "reaction_10503894", "reactome": "R-CEL-71296", "name": "D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_31467" ], "products": [ "species_29996" ], "modifiers": [ [ "species_10503891", "catalyst" ] ], "additional_components": [ "WBGene00013301" ] }, "reaction_10514364": { "compartment": "compartment_70101", "id": "reaction_10514364", "reactome": "R-CEL-199803", "name": "xylulose 5-phosphate <=> D-ribulose 5-phosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29790" ], "products": [ "species_29732" ], "modifiers": [ [ "species_10503921", "catalyst" ] ], "additional_components": [ "Q95ZW2", "WBGene00017272", "species_113531" ] }, "reaction_10570173": { "compartment": "compartment_70101", "id": "reaction_10570173", "reactome": "R-CEL-8959719", "name": "SHPK phosphorylates Sedo to Sedo7P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_8959707" ], "products": [ "species_70106", "species_29370", "species_29882" ], "modifiers": [ [ "species_10570170", "catalyst" ] ], "additional_components": [ "WBGene00012017" ] }, "reaction_10503076": { "compartment": "compartment_70101", "id": "reaction_10503076", "reactome": "R-CEL-70479", "name": "D-fructose 1,6-bisphosphate + H2O => D-fructose 6-phosphate + orthophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30014", "species_29356" ], "products": [ "species_29372", "species_29512" ], "modifiers": [ [ "species_10503073", "catalyst" ], [ "species_76577", "inhibitor" ] ], "additional_components": [ "species_114632", "G5EBJ7", "WBGene00001404" ] }, "reaction_10513893": { "compartment": "compartment_70101", "id": "reaction_10513893", "reactome": "R-CEL-198508", "name": "malate + NAD+ <=> oxaloacetate + NADH + H+", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_198498", "species_29360" ], "products": [ "species_70106", "species_76213", "species_73473" ], "modifiers": [ [ "species_10513890", "catalyst" ] ], "additional_components": [ "Q9UAV5", "WBGene00018491" ] }, "reaction_10502823": { "compartment": "compartment_70101", "id": "reaction_10502823", "reactome": "R-CEL-70241", "name": "oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [cytosol]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_76213" ], "products": [ "species_29420", "species_113528", "species_29492" ], "modifiers": [ [ "species_10502820", "catalyst" ] ], "additional_components": [ "Q9TYQ8", "WBGene00019151", "O02286", "WBGene00011232", "O44906", "WBGene00021043" ] }, "reaction_10519528": { "compartment": "compartment_70101", "id": "reaction_10519528", "reactome": "R-CEL-376851", "name": "Exchange of alpha-ketoglutarate (2-oxoglutarate) and malate across the inner mitochondrial membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113594", "species_198498" ], "products": [ "species_29406", "species_113544" ], "modifiers": [ [ "species_10513880", "catalyst" ] ], "additional_components": [ "P90992", "WBGene00015186" ] }, "reaction_10513901": { "compartment": "compartment_70101", "id": "reaction_10513901", "reactome": "R-CEL-198513", "name": "Cytosolic glucose 6-phosphate is exchanged for orthophosphate from the endoplasmic reticulum lumen by SLC37A4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113551", "species_30537" ], "products": [ "species_29372", "species_113782" ], "modifiers": [ [ "species_10513898", "catalyst" ] ], "additional_components": [ "WBGene00302978" ] }, "reaction_10518414": { "compartment": "compartment_5460", "id": "reaction_10518414", "reactome": "R-CEL-372819", "name": "oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [mitochondrial matrix]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113573", "species_113587" ], "products": [ "species_372364", "species_113525", "species_29376" ], "modifiers": [ [ "species_10518411", "catalyst" ] ], "additional_components": [ "WBGene00011232" ] }, "reaction_10503122": { "compartment": "compartment_5460", "id": "reaction_10503122", "reactome": "R-CEL-70501", "name": "Pyruvate + CO2 + ATP => ADP + Orthophosphate + Oxaloacetate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113593", "species_113557", "species_29376" ], "products": [ "species_113548", "species_113581", "species_113587" ], "modifiers": [ [ "species_10503119", "catalyst" ], [ "species_113559", "catalyst" ] ], "additional_components": [ "species_266099", "O17732", "WBGene00004258", "species_199207" ] }, "reaction_10518291": { "compartment": "compartment_70101", "id": "reaction_10518291", "reactome": "R-CEL-372449", "name": "phosphoenolpyruvate [mitochondrial matrix] + citrate [cytosol] => phosphoenolpyruvate [cytosol] + citrate [mitochondrial matrix]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76190", "species_372364" ], "products": [ "species_29654", "species_29492" ], "modifiers": [ [ "species_10507389", "catalyst" ] ], "additional_components": [ "WBGene00010780" ] }, "reaction_10518422": { "compartment": "compartment_70101", "id": "reaction_10518422", "reactome": "R-CEL-372843", "name": "malate [mitochondrial matrix] + orthophosphate [cytosol] <=> malate [cytosol] + orthophosphate [mitochondrial matrix]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29372", "species_113544" ], "products": [ "species_113548", "species_198498" ], "modifiers": [ [ "species_10518419", "catalyst" ] ], "additional_components": [ "WBGene00019656" ] }, "reaction_10513883": { "compartment": "compartment_70101", "id": "reaction_10513883", "reactome": "R-CEL-198440", "name": "malate [mitochondrial matrix] + alpha-ketoglutarate [cytosol] <=> malate [cytosol] + alpha-ketoglutarate [mitochondrial matrix]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29406", "species_113544" ], "products": [ "species_113594", "species_198498" ], "modifiers": [ [ "species_10513880", "catalyst" ] ], "additional_components": [ "P90992", "WBGene00015186" ] }, "reaction_10571905": { "compartment": "compartment_17963", "id": "reaction_10571905", "reactome": "R-CEL-9603986", "name": "FUT3 transfers Fuc to Type 1 chains to form LeA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9036984", "species_205683" ], "products": [ "species_205689", "species_9605607" ], "modifiers": [ [ "species_10557156", "catalyst" ] ], "additional_components": [ "WBGene00016163" ] }, "reaction_10571890": { "compartment": "compartment_17963", "id": "reaction_10571890", "reactome": "R-CEL-9603982", "name": "FUT2 transfers Fuc to LeA to form LeB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9605607", "species_205683" ], "products": [ "species_205689", "species_9605394" ], "modifiers": [ [ "species_10571827", "catalyst" ] ], "additional_components": [ "WBGene00015019" ] }, "reaction_10571973": { "compartment": "compartment_17963", "id": "reaction_10571973", "reactome": "R-CEL-9605682", "name": "FUT3,5,6,7 transfers Fuc to Type 2 MSGG to form sLeX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9605685", "species_205683" ], "products": [ "species_9605661", "species_205689" ], "modifiers": [ [ "species_10571970", "catalyst" ] ], "additional_components": [ "Q18255", "WBGene00016163" ] }, "reaction_10571892": { "compartment": "compartment_17963", "id": "reaction_10571892", "reactome": "R-CEL-9603983", "name": "FUT2 transfers Fuc to LeX to form LeY", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9605593", "species_205683" ], "products": [ "species_205689", "species_9605586" ], "modifiers": [ [ "species_10571827", "catalyst" ] ], "additional_components": [ "WBGene00015019" ] }, "reaction_10571946": { "compartment": "compartment_17963", "id": "reaction_10571946", "reactome": "R-CEL-9603989", "name": "B3GALTs transfer Gal to GlcNAc-1,3-Gal-R to form Type 1 chain", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9604808", "species_735682" ], "products": [ "species_205687", "species_9036984" ], "modifiers": [ [ "species_10571943", "catalyst" ] ], "additional_components": [ "Q95US5", "WBGene00000270", "Q9XU74", "WBGene00011780", "G5EDB3", "WBGene00044630", "G5ECA6", "WBGene00011780", "H2L0F4", "WBGene00044618", "O02231", "WBGene00011780", "O02310", "WBGene00011780", "O17750", "WBGene00011780", "O62114", "WBGene00011780", "O62115", "WBGene00011780", "O62163", "WBGene00011780", "O62165", "WBGene00011780", "O62375", "WBGene00011780", "Q20575", "WBGene00011780", "Q6QMT2", "WBGene00000267", "Q8MQG4", "WBGene00011780" ] }, "reaction_10571964": { "compartment": "compartment_17963", "id": "reaction_10571964", "reactome": "R-CEL-9605609", "name": "FUT3 transfers Fuc to Type 1 MSGG to form sLeA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9605595", "species_205683" ], "products": [ "species_9605615", "species_205689" ], "modifiers": [ [ "species_10557156", "catalyst" ] ], "additional_components": [ "WBGene00016163" ] }, "reaction_10571903": { "compartment": "compartment_17963", "id": "reaction_10571903", "reactome": "R-CEL-9603984", "name": "FUT4,5,9,(10,11) transfer Fuc to Type 2 chains to form LeX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9033790", "species_205683" ], "products": [ "species_9605593", "species_205689" ], "modifiers": [ [ "species_10571900", "catalyst" ] ], "additional_components": [ "Q18255", "WBGene00016163" ] }, "reaction_10571966": { "compartment": "compartment_17963", "id": "reaction_10571966", "reactome": "R-CEL-9605644", "name": "FUT3 transfers Fuc to Type 1 DSGG to form dsLeA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9605649", "species_205683" ], "products": [ "species_205689", "species_9605651" ], "modifiers": [ [ "species_10557156", "catalyst" ] ], "additional_components": [ "WBGene00016163" ] }, "reaction_10510218": { "compartment": "compartment_7660", "id": "reaction_10510218", "reactome": "R-CEL-163664", "name": "AMP binds to gamma subunit of AMP kinase heterotrimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_164121", "species_10510212" ], "products": [ "species_10510216" ], "modifiers": [], "additional_components": [ "Q9N501", "WBGene00021527", "A0A1T5HUK9", "WBGene00013732", "H2L0K0", "WBGene00020135", "O02168", "WBGene00020633", "Q95ZQ4", "WBGene00020142", "Q9XUY2", "WBGene00010115", "Q9N501", "WBGene00021527", "A0A1T5HUK9", "WBGene00013732", "H2L0K0", "WBGene00020135", "O02168", "WBGene00020633", "species_76577", "Q95ZQ4", "WBGene00020142", "Q9XUY2", "WBGene00010115" ] }, "reaction_10517761": { "compartment": "compartment_876", "id": "reaction_10517761", "reactome": "R-CEL-265645", "name": "Calcium Influx through Voltage-gated Calcium Channels", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74112" ], "products": [ "species_74016" ], "modifiers": [ [ "species_10517758", "catalyst" ] ], "additional_components": [ "G5EG74", "WBGene00007041", "P34374", "WBGene00006772", "Q8MQA1", "WBGene00001187", "A0A3B1E663", "WBGene00006742" ] }, "reaction_10527093": { "compartment": "compartment_876", "id": "reaction_10527093", "reactome": "R-CEL-499981", "name": "Transport of Extracellular Glucose to the Cytosol by GLUT1 and GLUT2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70115" ], "products": [ "species_70113" ], "modifiers": [ [ "species_10527090", "catalyst" ] ], "additional_components": [ "Q23626", "WBGene00022014", "Q95QY6", "WBGene00022014", "Q9GPA2", "WBGene00022014", "Q9N309", "WBGene00022014", "Q9U2K5", "WBGene00022014", "Q9XU83", "WBGene00022014", "Q9XVL3", "WBGene00022014", "G5EC93", "WBGene00022014", "O16547", "WBGene00022014", "O44616", "WBGene00022014", "O44827", "WBGene00019207", "O45920", "WBGene00022014", "Q11114", "WBGene00022014", "Q19376", "WBGene00022014", "Q20734", "WBGene00022014", "Q23535", "WBGene00006865", "Q21381", "WBGene00043980", "Q9GYQ1", "WBGene00043980", "Q21382", "WBGene00043980", "Q9NEI8", "WBGene00043980", "Q21385", "WBGene00043980", "Q5WRR9", "WBGene00043980" ] }, "reaction_10510248": { "compartment": "compartment_7660", "id": "reaction_10510248", "reactome": "R-CEL-163743", "name": "Transcriptional activation of Acetyl-CoA carboxylase by ChREBP:MLX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [], "products": [ "species_10510246" ], "modifiers": [ [ "species_10510237", "catalyst" ] ], "additional_components": [ "Q9XUC3", "WBGene00012131", "H2L0M0", "WBGene00004076", "P41846", "WBGene00003378", "Q9TZ70", "WBGene00003510" ] }, "reaction_10510250": { "compartment": "compartment_7660", "id": "reaction_10510250", "reactome": "R-CEL-163748", "name": "Transcriptional activation of GP-acyl transferase gene by ChREBP:MLX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [], "products": [ "species_10507496" ], "modifiers": [ [ "species_10510237", "catalyst" ] ], "additional_components": [ "Q22267", "WBGene00011543", "Q93841", "WBGene00010339", "P41846", "WBGene00003378", "Q9TZ70", "WBGene00003510" ] }, "reaction_10510239": { "compartment": "compartment_7660", "id": "reaction_10510239", "reactome": "R-CEL-163733", "name": "Transcriptional activation of FAS monomer gene by ChREBP:MLX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [], "products": [ "species_10507450" ], "modifiers": [ [ "species_10510237", "catalyst" ] ], "additional_components": [ "WBGene00009342", "P41846", "WBGene00003378", "Q9TZ70", "WBGene00003510" ] }, "reaction_10568065": { "compartment": "compartment_70101", "id": "reaction_10568065", "reactome": "R-CEL-8932851", "name": "PQLC2 transports L-Arg,L-His,L-Lys from lysosomal lumen to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8932838" ], "products": [ "species_8932842" ], "modifiers": [ [ "species_10568062", "catalyst" ] ], "additional_components": [ "species_29612", "species_29444", "species_29468", "species_29468", "species_29612", "species_29444", "WBGene00021546" ] }, "reaction_10551456": { "compartment": "compartment_70101", "id": "reaction_10551456", "reactome": "R-CEL-5336453", "name": "NIPAs transport Mg2+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_114632" ], "products": [ "species_29926" ], "modifiers": [ [ "species_10551447", "catalyst" ] ], "additional_components": [ "WBGene00021820" ] }, "reaction_10551488": { "compartment": "compartment_70101", "id": "reaction_10551488", "reactome": "R-CEL-5340130", "name": "CTNS cotransports CySS-, H+ from lysosomal lumen to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428040", "species_5673778" ], "products": [ "species_70106", "species_379444" ], "modifiers": [ [ "species_10551485", "catalyst" ] ], "additional_components": [ "WBGene00008052" ] }, "reaction_10550773": { "compartment": "compartment_70101", "id": "reaction_10550773", "reactome": "R-CEL-5226999", "name": "ADD1:ADD3 binds DMTN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10550757", "species_10550769" ], "products": [ "species_10550771" ], "modifiers": [], "additional_components": [ "WBGene00006839", "Q20952", "WBGene00000073", "Q9U9K0", "WBGene00000072", "Q20952", "WBGene00000073", "Q9U9K0", "WBGene00000072", "Q95QM5", "WBGene00006839" ] }, "reaction_10550761": { "compartment": "compartment_70101", "id": "reaction_10550761", "reactome": "R-CEL-5226979", "name": "ADD1:ADD2 binds DMTN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10550757", "species_10550752" ], "products": [ "species_10550759" ], "modifiers": [], "additional_components": [ "WBGene00006839", "Q20952", "WBGene00000073", "Q9U9K0", "WBGene00000072", "Q20952", "WBGene00000073", "Q9U9K0", "WBGene00000072", "Q95QM5", "WBGene00006839" ] }, "reaction_10551480": { "compartment": "compartment_70101", "id": "reaction_10551480", "reactome": "R-CEL-5339538", "name": "MAGT1 transports Mg2+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_114632" ], "products": [ "species_29926" ], "modifiers": [ [ "species_10551477", "catalyst" ] ], "additional_components": [ "WBGene00022793" ] }, "reaction_10551467": { "compartment": "compartment_70101", "id": "reaction_10551467", "reactome": "R-CEL-5339528", "name": "TUSC3 transports Mg2+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_114632" ], "products": [ "species_29926" ], "modifiers": [ [ "species_10551464", "catalyst" ] ], "additional_components": [ "WBGene00022793" ] }, "reaction_10509864": { "compartment": "compartment_7660", "id": "reaction_10509864", "reactome": "R-CEL-156678", "name": "Activation of Cdc25C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10509856" ], "products": [ "species_29370", "species_10509859" ], "modifiers": [ [ "species_10509861", "catalyst" ] ], "additional_components": [ "WBGene00000389", "WBGene00000389", "WBGene00004043" ] }, "reaction_10510078": { "compartment": "compartment_7660", "id": "reaction_10510078", "reactome": "R-CEL-162657", "name": "Inactivation of Myt1 kinase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10510073" ], "products": [ "species_113582", "species_10510076" ], "modifiers": [ [ "species_10509851", "catalyst" ] ], "additional_components": [ "WBGene00006940", "WBGene00006940", "WBGene00004043" ] }, "reaction_10555392": { "compartment": "compartment_70101", "id": "reaction_10555392", "reactome": "R-CEL-5678863", "name": "CFTR transports Cl- from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_352022" ], "products": [ "species_188972", "species_29372", "species_29370" ], "modifiers": [ [ "species_10520442", "catalyst" ] ], "additional_components": [ "Q19625", "WBGene00003412", "Q95QV2", "WBGene00000477" ] }, "reaction_10534309": { "compartment": "compartment_70101", "id": "reaction_10534309", "reactome": "R-CEL-1454916", "name": "The ABCC family mediates organic anion transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_1454930" ], "products": [ "species_29372", "species_29370", "species_1454919" ], "modifiers": [ [ "species_10534306", "catalyst" ] ], "additional_components": [ "G5EE72", "WBGene00003411", "Q19625", "WBGene00003412", "Q95QV2", "WBGene00000477", "Q3S1M2", "WBGene00003407", "Q20943", "WBGene00003408", "G5EFP3", "WBGene00003410", "Q9U2G5", "WBGene00003413", "Q19048", "WBGene00003409", "Q9XW61", "WBGene00003414" ] }, "reaction_10566312": { "compartment": "compartment_12045", "id": "reaction_10566312", "reactome": "R-CEL-8866542", "name": "VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_10566310" ], "products": [ "species_10566284", "species_29372", "species_29370", "species_10566308" ], "modifiers": [], "additional_components": [ "Q93561", "WBGene00000843", "A3QMC6", "WBGene00016592", "G5EFG0", "WBGene00004759", "Q09396", "WBGene00018611", "Q9NF22", "WBGene00013667", "Q09463", "WBGene00004381", "P54812", "WBGene00008053", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "Q19625", "WBGene00003412", "Q95QV2", "WBGene00000477", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "Q19625", "WBGene00003412", "Q95QV2", "WBGene00000477", "Q93561", "WBGene00000843", "A3QMC6", "WBGene00016592", "G5EFG0", "WBGene00004759", "Q09396", "WBGene00018611", "Q9NF22", "WBGene00013667", "Q09463", "WBGene00004381", "P54812", "WBGene00008053" ] }, "reaction_10517776": { "compartment": "compartment_876", "id": "reaction_10517776", "reactome": "R-CEL-265783", "name": "ABCG5:ABCG8 transports sterols from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_265784", "species_113592" ], "products": [ "species_29372", "species_29370", "species_265781" ], "modifiers": [ [ "species_10517773", "catalyst" ] ], "additional_components": [ "CHEBI:26125", "species_193384", "CHEBI:26125", "species_193384", "Q18900", "WBGene00016973", "D7SFK1", "WBGene00006522" ] }, "reaction_10520430": { "compartment": "compartment_17947", "id": "reaction_10520430", "reactome": "R-CEL-382613", "name": "PEX-19 docks ABCD1/D2/D3 to peroximal membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10520428", "species_10520404" ], "products": [ "species_10520396", "species_10520426", "species_10520404" ], "modifiers": [], "additional_components": [ "O45730", "WBGene00004061", "Q18598", "WBGene00004059", "P34453", "WBGene00004201", "WBGene00004193", "O45730", "WBGene00004061", "Q18598", "WBGene00004059", "WBGene00004201", "WBGene00004193" ] }, "reaction_10520399": { "compartment": "compartment_17947", "id": "reaction_10520399", "reactome": "R-CEL-382575", "name": "ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_382577" ], "products": [ "species_382571", "species_29372", "species_29370" ], "modifiers": [ [ "species_10520396", "catalyst" ] ], "additional_components": [ "O45730", "WBGene00004061", "Q18598", "WBGene00004059" ] }, "reaction_10550732": { "compartment": "compartment_70101", "id": "reaction_10550732", "reactome": "R-CEL-5223317", "name": "ABCB9 transports peptides from cytosol to lysosomal lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_5223341" ], "products": [ "species_5223344", "species_29372", "species_29370" ], "modifiers": [ [ "species_10550729", "catalyst" ] ], "additional_components": [ "O02086", "WBGene00001812" ] }, "reaction_10566317": { "compartment": "compartment_12045", "id": "reaction_10566317", "reactome": "R-CEL-8866546", "name": "RNF5 and RNF185 ubiquitinate misfolded CFTR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10566314", "species_10502375" ], "products": [ "species_10566310" ], "modifiers": [ [ "species_10566314", "catalyst" ] ], "additional_components": [ "Q93561", "WBGene00000843", "A3QMC6", "WBGene00016592", "G5EFG0", "WBGene00004759", "Q09396", "WBGene00018611", "Q9NF22", "WBGene00013667", "Q09463", "WBGene00004381", "P54812", "WBGene00008053", "Q19625", "WBGene00003412", "Q95QV2", "WBGene00000477", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "Q93561", "WBGene00000843", "A3QMC6", "WBGene00016592", "G5EFG0", "WBGene00004759", "Q09396", "WBGene00018611", "Q9NF22", "WBGene00013667", "Q09463", "WBGene00004381", "P54812", "WBGene00008053", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "Q19625", "WBGene00003412", "Q95QV2", "WBGene00000477", "Q93561", "WBGene00000843", "A3QMC6", "WBGene00016592", "G5EFG0", "WBGene00004759", "Q09396", "WBGene00018611", "Q9NF22", "WBGene00013667", "Q09463", "WBGene00004381", "P54812", "WBGene00008053", "Q19625", "WBGene00003412", "Q95QV2", "WBGene00000477" ] }, "reaction_10520374": { "compartment": "compartment_70616", "id": "reaction_10520374", "reactome": "R-CEL-382560", "name": "ABC7, mABC1 and mABC2 mediate heme transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113593", "species_189444", "species_113521" ], "products": [ "species_113548", "species_113581", "species_71185" ], "modifiers": [ [ "species_10520371", "catalyst" ] ], "additional_components": [ "G4SRS5", "WBGene00022281" ] }, "reaction_10533110": { "compartment": "compartment_17906", "id": "reaction_10533110", "reactome": "R-CEL-1369065", "name": "ABCB6 transports porphyrin from cytosol to mitchondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1369066", "species_29356", "species_113592" ], "products": [ "species_29372", "species_29370", "species_1369027" ], "modifiers": [ [ "species_10533107", "catalyst" ] ], "additional_components": [ "G5EFD4", "WBGene00001815" ] }, "reaction_10566319": { "compartment": "compartment_12045", "id": "reaction_10566319", "reactome": "R-CEL-8866551", "name": "CFTR binds components of the ERAD machinery for ubiquitination and degradation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10566282", "species_10566308" ], "products": [ "species_10566314" ], "modifiers": [], "additional_components": [ "Q19625", "WBGene00003412", "Q95QV2", "WBGene00000477", "Q93561", "WBGene00000843", "A3QMC6", "WBGene00016592", "G5EFG0", "WBGene00004759", "Q09396", "WBGene00018611", "Q9NF22", "WBGene00013667", "Q09463", "WBGene00004381", "P54812", "WBGene00008053", "Q93561", "WBGene00000843", "A3QMC6", "WBGene00016592", "G5EFG0", "WBGene00004759", "Q09396", "WBGene00018611", "Q9NF22", "WBGene00013667", "Q09463", "WBGene00004381", "P54812", "WBGene00008053", "Q19625", "WBGene00003412", "Q95QV2", "WBGene00000477" ] }, "reaction_10566321": { "compartment": "compartment_70101", "id": "reaction_10566321", "reactome": "R-CEL-8866553", "name": "misfolded CFTR is degraded by the 26S proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10566284" ], "products": [ "species_10502375" ], "modifiers": [ [ "species_10502572", "catalyst" ] ], "additional_components": [ "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "Q19625", "WBGene00003412", "Q95QV2", "WBGene00000477", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "P91477", "WBGene00003950", "Q95PZ7", "WBGene00013435", "Q18115", "WBGene00004459", "O62102", "WBGene00003948", "O17071", "WBGene00004504", "Q10920", "WBGene00016623", "P34286", "WBGene00003952", "Q9XTT9", "WBGene00004506", "Q23449", "WBGene00004468", "Q95005", "WBGene00003925", "P46502", "WBGene00004503", "O61792", "WBGene00004464", "O17586", "WBGene00003922", "O76371", "WBGene00004505", "Q20585", "WBGene00004463", "Q95008", "WBGene00003926", "Q18787", "WBGene00004501", "Q20058", "WBGene00009445", "Q9N599", "WBGene00003924", "O16368", "WBGene00004502", "O61742", "WBGene00004466", "Q09583", "WBGene00003928", "Q966I8", "WBGene00003947", "Q04908", "WBGene00004460", "Q9XUV0", "WBGene00003951", "Q27488", "WBGene00003923", "Q9GZH5", "WBGene00004458", "O44156", "WBGene00003927", "Q22253", "WBGene00004465", "O76577", "WBGene00004467", "P90868", "WBGene00003953", "Q19324", "WBGene00004461", "Q17971", "WBGene00007588", "Q23237", "WBGene00003949", "Q20938", "WBGene00004462" ] }, "reaction_10534322": { "compartment": "compartment_876", "id": "reaction_10534322", "reactome": "R-CEL-1467457", "name": "ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_1131652" ], "products": [ "species_29372", "species_29370", "species_1467459" ], "modifiers": [ [ "species_10534319", "catalyst" ] ], "additional_components": [ "P34712", "WBGene00003995", "G5EG58", "WBGene00004003" ] }, "reaction_10555389": { "compartment": "compartment_984", "id": "reaction_10555389", "reactome": "R-CEL-5678706", "name": "ABCB4 transports PC from plasma membrane to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_429802", "species_113592" ], "products": [ "species_382539", "species_29372", "species_29370" ], "modifiers": [ [ "species_10555386", "catalyst" ] ], "additional_components": [ "G5EG58", "WBGene00004003", "P34712", "WBGene00003995" ] }, "reaction_10566333": { "compartment": "compartment_876", "id": "reaction_10566333", "reactome": "R-CEL-8866851", "name": "CFTR transits to the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10566282" ], "products": [ "species_10520442" ], "modifiers": [], "additional_components": [ "Q19625", "WBGene00003412", "Q95QV2", "WBGene00000477", "Q19625", "WBGene00003412", "Q95QV2", "WBGene00000477" ] }, "reaction_10520445": { "compartment": "compartment_876", "id": "reaction_10520445", "reactome": "R-CEL-383190", "name": "HCO3- transport through ion channel", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_111627", "species_113592" ], "products": [ "species_29372", "species_29370", "species_425425" ], "modifiers": [ [ "species_10520442", "catalyst" ] ], "additional_components": [ "Q19625", "WBGene00003412", "Q95QV2", "WBGene00000477" ] }, "reaction_10550782": { "compartment": "compartment_70101", "id": "reaction_10550782", "reactome": "R-CEL-5227009", "name": "ABCF1 binds EIF2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10505631", "species_10550778" ], "products": [ "species_10550780" ], "modifiers": [], "additional_components": [ "Q9BKU3", "WBGene00021351", "Q21230", "WBGene00010560", "Q95XR0", "WBGene00021466", "WBGene00006512", "Q19554", "WBGene00006512", "Q9BKU3", "WBGene00021351", "Q21230", "WBGene00010560", "Q95XR0", "WBGene00021466" ] }, "reaction_10518493": { "compartment": "compartment_70101", "id": "reaction_10518493", "reactome": "R-CEL-373705", "name": "Caspase cleavage of DCC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10518486" ], "products": [ "species_10518490", "species_10518488" ], "modifiers": [ [ "species_10509422", "catalyst" ] ], "additional_components": [ "P42573", "WBGene00000417" ] }, "reaction_10556804": { "compartment": "compartment_70101", "id": "reaction_10556804", "reactome": "R-CEL-5691108", "name": "SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502375", "species_10556692" ], "products": [ "species_10556795" ], "modifiers": [ [ "species_10556801", "catalyst" ] ], "additional_components": [ "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "WBGene00000040", "WBGene00000040", "Q93725", "WBGene00003587", "G5ECU1", "WBGene00004807", "Q17389", "WBGene00000836" ] }, "reaction_10535239": { "compartment": "compartment_70101", "id": "reaction_10535239", "reactome": "R-CEL-1562626", "name": "Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_71067", "species_29368" ], "products": [ "species_5691103" ], "modifiers": [ [ "species_10535236", "catalyst" ] ], "additional_components": [ "O16453", "WBGene00001500", "Q9TYS3", "WBGene00001501" ] }, "reaction_10556813": { "compartment": "compartment_70101", "id": "reaction_10556813", "reactome": "R-CEL-5691131", "name": "CANDI binds CUL1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10516329", "species_10556809" ], "products": [ "species_10556811" ], "modifiers": [], "additional_components": [ "WBGene00000836", "WBGene00013606", "G5ED41", "WBGene00013606", "Q17389", "WBGene00000836" ] }, "reaction_10529202": { "compartment": "compartment_984", "id": "reaction_10529202", "reactome": "R-CEL-917805", "name": "CYBRD1:Heme reduces Fe3+ to Fe2+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_917828", "species_912516" ], "products": [ "species_435347" ], "modifiers": [ [ "species_10529199", "catalyst" ] ], "additional_components": [ "species_71185", "O16271", "WBGene00018210" ] }, "reaction_10556690": { "compartment": "compartment_70101", "id": "reaction_10556690", "reactome": "R-CEL-5690873", "name": "ACO1 binds 4Fe-4S", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10556686", "species_5690881" ], "products": [ "species_10556688" ], "modifiers": [], "additional_components": [ "WBGene00000040", "Q23500", "WBGene00000040" ] }, "reaction_10556695": { "compartment": "compartment_70101", "id": "reaction_10556695", "reactome": "R-CEL-5690911", "name": "ACO1:4Fe-4S isomerises CIT to ISCIT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76190" ], "products": [ "species_389545" ], "modifiers": [ [ "species_10556688", "catalyst" ] ], "additional_components": [ "Q23500", "WBGene00000040" ] }, "reaction_10556792": { "compartment": "compartment_5460", "id": "reaction_10556792", "reactome": "R-CEL-5691107", "name": "FTMT 24mer oxidises 4Fe2+ to 4Fe(3+)O(OH)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113533", "species_113531", "species_113529" ], "products": [ "species_5691135" ], "modifiers": [ [ "species_10556789", "catalyst" ] ], "additional_components": [ "Q9TYS3", "WBGene00001501", "O16453", "WBGene00001500" ] }, "reaction_10529210": { "compartment": "compartment_947586", "id": "reaction_10529210", "reactome": "R-CEL-917891", "name": "SLC40A1:CP:6Cu2+ oxidises Fe2+ to Fe3+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_435347", "species_352327" ], "products": [ "species_109276", "species_912516" ], "modifiers": [ [ "species_10528427", "catalyst" ] ], "additional_components": [ "Q19687", "WBGene00009008", "species_209799", "O44607", "WBGene00019977", "Q8IA95", "WBGene00021354" ] }, "reaction_10529213": { "compartment": "compartment_947586", "id": "reaction_10529213", "reactome": "R-CEL-917933", "name": "SLC40A1:HEPH:6Cu2+ oxidises 4Fe2+ to 4Fe3+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_435347", "species_352327" ], "products": [ "species_109276", "species_912516" ], "modifiers": [ [ "species_10524363", "catalyst" ] ], "additional_components": [ "O44607", "WBGene00019977", "Q8IA95", "WBGene00021354", "CHEBI:28694", "Q19687", "WBGene00009008" ] }, "reaction_10534717": { "compartment": "compartment_70101", "id": "reaction_10534717", "reactome": "R-CEL-1475435", "name": "CA1:Zn2+,CA2:Zn2+ hydrate CO2 to HCO3-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113528" ], "products": [ "species_70106", "species_111627" ], "modifiers": [ [ "species_10534714", "catalyst" ] ], "additional_components": [ "O02637", "WBGene00000284", "Q10462", "WBGene00000283", "Q21614", "WBGene00000282", "Q27504", "WBGene00000281", "species_216785" ] }, "reaction_10570305": { "compartment": "compartment_70101", "id": "reaction_10570305", "reactome": "R-CEL-8981570", "name": "GLUT4 (SLC2A4) tetramer transports Glc from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70115" ], "products": [ "species_70113" ], "modifiers": [ [ "species_10570302", "catalyst" ] ], "additional_components": [ "O44827", "WBGene00019207" ] }, "reaction_10551459": { "compartment": "compartment_70101", "id": "reaction_10551459", "reactome": "R-CEL-5339524", "name": "GLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70115" ], "products": [ "species_70113" ], "modifiers": [ [ "species_10525428", "catalyst" ], [ "species_113592", "inhibitor" ] ], "additional_components": [ "Q21381", "WBGene00043980", "Q9GYQ1", "WBGene00043980", "Q21382", "WBGene00043980", "Q9NEI8", "WBGene00043980", "Q21385", "WBGene00043980", "Q5WRR9", "WBGene00043980" ] }, "reaction_10570307": { "compartment": "compartment_70101", "id": "reaction_10570307", "reactome": "R-CEL-8981574", "name": "GLUT2 (SLC2A2) tetramer transports Glc from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70115" ], "products": [ "species_70113" ], "modifiers": [ [ "species_10512849", "catalyst" ] ], "additional_components": [ "Q23626", "WBGene00022014", "Q95QY6", "WBGene00022014", "Q9GPA2", "WBGene00022014", "Q9N309", "WBGene00022014", "Q9U2K5", "WBGene00022014", "Q9XU83", "WBGene00022014", "Q9XVL3", "WBGene00022014", "G5EC93", "WBGene00022014", "O16547", "WBGene00022014", "O44616", "WBGene00022014", "O44827", "WBGene00019207", "O45920", "WBGene00022014", "Q11114", "WBGene00022014", "Q19376", "WBGene00022014", "Q20734", "WBGene00022014", "Q23535", "WBGene00006865" ] }, "reaction_10570293": { "compartment": "compartment_70101", "id": "reaction_10570293", "reactome": "R-CEL-8981553", "name": "GLUT14 (SLC2A14) tetramer transports Glc from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70115" ], "products": [ "species_70113" ], "modifiers": [ [ "species_10570290", "catalyst" ] ], "additional_components": [ "Q21381", "WBGene00043980", "Q21382", "WBGene00043980", "Q21385", "WBGene00043980", "Q5WRR9", "WBGene00043980", "Q9GYQ1", "WBGene00043980", "Q9NEI8", "WBGene00043980" ] }, "reaction_10523383": { "compartment": "compartment_876", "id": "reaction_10523383", "reactome": "R-CEL-429036", "name": "SLC2A9 transports Fru, Glc, urate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_429078" ], "products": [ "species_429148" ], "modifiers": [ [ "species_10523380", "catalyst" ] ], "additional_components": [ "species_70113", "species_30034", "species_29532", "species_70113", "species_30034", "species_29532", "Q19376", "WBGene00022014", "Q20734", "WBGene00022014", "Q23535", "WBGene00006865", "Q23626", "WBGene00022014", "Q95QY6", "WBGene00022014", "Q9GPA2", "WBGene00022014", "Q9N309", "WBGene00022014", "Q9U2K5", "WBGene00022014", "Q9XU83", "WBGene00022014", "Q9XVL3", "WBGene00022014", "G5EC93", "WBGene00022014", "O16547", "WBGene00022014", "O44616", "WBGene00022014", "O44827", "WBGene00019207", "O45920", "WBGene00022014", "Q11114", "WBGene00022014" ] }, "reaction_10523335": { "compartment": "compartment_876", "id": "reaction_10523335", "reactome": "R-CEL-428779", "name": "GLUT7 and GLUT11 transport glucose and fructose", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428819" ], "products": [ "species_428802" ], "modifiers": [ [ "species_10523332", "catalyst" ] ], "additional_components": [ "species_70113", "species_29532", "species_70113", "species_29532", "G5EC93", "WBGene00022014", "O16547", "WBGene00022014", "O44616", "WBGene00022014", "O44827", "WBGene00019207", "O45920", "WBGene00022014", "Q11114", "WBGene00022014", "Q19376", "WBGene00022014", "Q20734", "WBGene00022014", "Q23535", "WBGene00006865", "Q23626", "WBGene00022014", "Q95QY6", "WBGene00022014", "Q9GPA2", "WBGene00022014", "Q9N309", "WBGene00022014", "Q9U2K5", "WBGene00022014", "Q9XU83", "WBGene00022014", "Q9XVL3", "WBGene00022014" ] }, "reaction_10525432": { "compartment": "compartment_70101", "id": "reaction_10525432", "reactome": "R-CEL-450088", "name": "GLUT1 tetramer binds 4xATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10525428" ], "products": [ "species_10525430" ], "modifiers": [], "additional_components": [ "Q21381", "WBGene00043980", "Q9GYQ1", "WBGene00043980", "Q21382", "WBGene00043980", "Q9NEI8", "WBGene00043980", "Q21385", "WBGene00043980", "Q5WRR9", "WBGene00043980", "Q21381", "WBGene00043980", "Q9GYQ1", "WBGene00043980", "Q21382", "WBGene00043980", "Q9NEI8", "WBGene00043980", "Q21385", "WBGene00043980", "Q5WRR9", "WBGene00043980", "species_29358" ] }, "reaction_10525434": { "compartment": "compartment_70101", "id": "reaction_10525434", "reactome": "R-CEL-450092", "name": "GLUT1:ATP tetramer dissociates to GLUT1 tetramer and 4xATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10525430" ], "products": [ "species_113592", "species_10525428" ], "modifiers": [], "additional_components": [ "Q21381", "WBGene00043980", "Q9GYQ1", "WBGene00043980", "Q21382", "WBGene00043980", "Q9NEI8", "WBGene00043980", "Q21385", "WBGene00043980", "Q5WRR9", "WBGene00043980", "species_29358", "Q21381", "WBGene00043980", "Q9GYQ1", "WBGene00043980", "Q21382", "WBGene00043980", "Q9NEI8", "WBGene00043980", "Q21385", "WBGene00043980", "Q5WRR9", "WBGene00043980" ] }, "reaction_10570298": { "compartment": "compartment_70101", "id": "reaction_10570298", "reactome": "R-CEL-8981564", "name": "GLUT3 (SLC2A3) tetramer transports Glc from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70115" ], "products": [ "species_70113" ], "modifiers": [ [ "species_10570295", "catalyst" ] ], "additional_components": [ "Q9NEI8", "WBGene00043980" ] }, "reaction_10525437": { "compartment": "compartment_70101", "id": "reaction_10525437", "reactome": "R-CEL-450095", "name": "GLUT2 (SLC2A2) transports Glc from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70113" ], "products": [ "species_70115" ], "modifiers": [ [ "species_10512849", "catalyst" ] ], "additional_components": [ "Q23626", "WBGene00022014", "Q95QY6", "WBGene00022014", "Q9GPA2", "WBGene00022014", "Q9N309", "WBGene00022014", "Q9U2K5", "WBGene00022014", "Q9XU83", "WBGene00022014", "Q9XVL3", "WBGene00022014", "G5EC93", "WBGene00022014", "O16547", "WBGene00022014", "O44616", "WBGene00022014", "O44827", "WBGene00019207", "O45920", "WBGene00022014", "Q11114", "WBGene00022014", "Q19376", "WBGene00022014", "Q20734", "WBGene00022014", "Q23535", "WBGene00006865" ] }, "reaction_10522496": { "compartment": "compartment_876", "id": "reaction_10522496", "reactome": "R-CEL-425678", "name": "SLC24A1-4 exchange extracellular 4Na+ for cytosolic Ca2+, K+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804", "species_74016", "species_74113" ], "products": [ "species_74126", "species_83910", "species_74112" ], "modifiers": [ [ "species_10522493", "catalyst" ] ], "additional_components": [ "G5EC02", "WBGene00003570", "P90858", "WBGene00003569" ] }, "reaction_10522504": { "compartment": "compartment_876", "id": "reaction_10522504", "reactome": "R-CEL-425822", "name": "K+-independent Li+/Ca2+ exchanger transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_425815", "species_74016" ], "products": [ "species_425810", "species_74112" ], "modifiers": [ [ "species_10522501", "catalyst" ] ], "additional_components": [ "WBGene00003572" ] }, "reaction_10522595": { "compartment": "compartment_876", "id": "reaction_10522595", "reactome": "R-CEL-425994", "name": "Na+/H+ exchanger transport (at cell membrane)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_74113" ], "products": [ "species_351626", "species_83910" ], "modifiers": [ [ "species_10522592", "catalyst" ] ], "additional_components": [ "Q8T5S1", "WBGene00003730", "G5EDU2", "WBGene00003732", "H2L039", "WBGene00003734", "O16452", "WBGene00003731", "P35449", "WBGene00003736" ] }, "reaction_10522518": { "compartment": "compartment_172574", "id": "reaction_10522518", "reactome": "R-CEL-425965", "name": "SLC9A9 exchanges Na+ for H+ across the late endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_425999", "species_83910" ], "products": [ "species_425977", "species_70106" ], "modifiers": [ [ "species_10522515", "catalyst" ] ], "additional_components": [ "WBGene00003733" ] }, "reaction_10522525": { "compartment": "compartment_171062", "id": "reaction_10522525", "reactome": "R-CEL-425983", "name": "SLC9A6,7 exchange Na+ for H+ across the early endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_425978", "species_83910" ], "products": [ "species_70106", "species_425971" ], "modifiers": [ [ "species_10522520", "catalyst" ] ], "additional_components": [ "WBGene00003733" ] }, "reaction_10522607": { "compartment": "compartment_20699", "id": "reaction_10522607", "reactome": "R-CEL-426015", "name": "Na+/H+ exchanger transport (at trans-golgi membrane)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_425969", "species_83910" ], "products": [ "species_70106", "species_425958" ], "modifiers": [ [ "species_10522604", "catalyst" ] ], "additional_components": [ "G5ED88", "WBGene00003733", "G5EBN7", "WBGene00003735" ] }, "reaction_10522643": { "compartment": "compartment_876", "id": "reaction_10522643", "reactome": "R-CEL-426130", "name": "SLC12A3 cotransports Cl-, Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_188972", "species_74113" ], "products": [ "species_83910", "species_352022" ], "modifiers": [ [ "species_10522640", "catalyst" ] ], "additional_components": [ "H8ESD5", "WBGene00012543", "P34261", "WBGene00015131" ] }, "reaction_10522634": { "compartment": "compartment_876", "id": "reaction_10522634", "reactome": "R-CEL-426086", "name": "SLC12A1,2 cotransports Na+, K+, 2Cl- from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74126", "species_188972", "species_74113" ], "products": [ "species_29804", "species_83910", "species_352022" ], "modifiers": [ [ "species_10522631", "catalyst" ] ], "additional_components": [ "P34261", "WBGene00015131", "H8ESD5", "WBGene00012543" ] }, "reaction_10522683": { "compartment": "compartment_876", "id": "reaction_10522683", "reactome": "R-CEL-426155", "name": "SLC12A4,5,6,7 cotransport K+, Cl- from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804", "species_352022" ], "products": [ "species_74126", "species_188972" ], "modifiers": [ [ "species_10522680", "catalyst" ] ], "additional_components": [ "S6FWN4", "WBGene00006504", "H2KZC3", "WBGene00019205", "Q09573", "WBGene00019289" ] }, "reaction_10523043": { "compartment": "compartment_201753", "id": "reaction_10523043", "reactome": "R-CEL-428052", "name": "SLC17A6,7,8 exchange cytosolic L-Glu for synaptic vesicle H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29404", "species_428548" ], "products": [ "species_70106", "species_428614" ], "modifiers": [ [ "species_10523040", "catalyst" ] ], "additional_components": [ "P34644", "WBGene00001135", "Q10046", "WBGene00011556", "G5EEK1", "WBGene00010755" ] }, "reaction_10523476": { "compartment": "compartment_876", "id": "reaction_10523476", "reactome": "R-CEL-429767", "name": "Passive I- efflux mediated by SMCT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_209785" ], "products": [ "species_209818" ], "modifiers": [ [ "species_10523470", "catalyst" ] ], "additional_components": [ "WBGene00018716" ] }, "reaction_10567367": { "compartment": "compartment_70101", "id": "reaction_10567367", "reactome": "R-CEL-8875623", "name": "SLC25A18,A22 cotransport Glu, H+ from cytosol to mitochondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29404", "species_70106" ], "products": [ "species_113529", "species_113552" ], "modifiers": [ [ "species_10567364", "catalyst" ] ], "additional_components": [ "Q20847", "WBGene00018901", "Q93540", "WBGene00008979" ] }, "reaction_10523415": { "compartment": "compartment_876", "id": "reaction_10523415", "reactome": "R-CEL-429591", "name": "SLC5A5 cotransports Na+ with I- from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_209818", "species_74113" ], "products": [ "species_209785", "species_83910" ], "modifiers": [ [ "species_10516451", "catalyst" ] ], "additional_components": [ "WBGene00018716" ] }, "reaction_10523020": { "compartment": "compartment_876", "id": "reaction_10523020", "reactome": "R-CEL-428015", "name": "SLC1A1,2,3,6,7 cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_428027", "species_29804", "species_74113" ], "products": [ "species_74126", "species_427997", "species_70106", "species_83910" ], "modifiers": [ [ "species_10516538", "catalyst" ] ], "additional_components": [ "species_427963", "species_6810061", "species_113552", "species_427963", "species_6810061", "species_113552", "Q21353", "WBGene00001621", "Q21751", "WBGene00001624", "Q22682", "WBGene00001622", "Q9UAY8", "WBGene00001625", "O18210", "WBGene00001623", "Q10901", "WBGene00001620" ] }, "reaction_10519220": { "compartment": "compartment_876", "id": "reaction_10519220", "reactome": "R-CEL-375405", "name": "SLC36A2 cotransports Gly, L-Pro with H+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_375409" ], "products": [ "species_70106", "species_375414" ], "modifiers": [ [ "species_10519217", "catalyst" ] ], "additional_components": [ "species_113538", "species_159549", "species_159549", "species_113538", "O62286", "WBGene00010421", "P34479", "WBGene00010307", "G4SQY7", "WBGene00020837", "Q18595", "WBGene00016628", "O45936", "WBGene00012804", "Q9XX44", "WBGene00012629" ] }, "reaction_10519225": { "compartment": "compartment_876", "id": "reaction_10519225", "reactome": "R-CEL-375417", "name": "SLC36A1-mediated uptake of glycine, proline, and alanine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_375400" ], "products": [ "species_70106", "species_375411" ], "modifiers": [ [ "species_10519222", "catalyst" ] ], "additional_components": [ "species_29432", "species_113538", "species_159549", "species_159549", "species_113538", "species_29432", "WBGene00012804" ] }, "reaction_10522933": { "compartment": "compartment_876", "id": "reaction_10522933", "reactome": "R-CEL-427605", "name": "SLC20A1,2 cotransport Pi, Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109277", "species_74113" ], "products": [ "species_29372", "species_83910" ], "modifiers": [ [ "species_10522930", "catalyst" ] ], "additional_components": [ "P91840", "WBGene00012285", "Q17454", "WBGene00015054", "O17404", "WBGene00017312", "Q17455", "WBGene00015055", "O45220", "WBGene00007141", "Q18697", "WBGene00016739" ] }, "reaction_10522941": { "compartment": "compartment_876", "id": "reaction_10522941", "reactome": "R-CEL-427645", "name": "SLC34A3 cotransports Pi, 2Na+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109277", "species_74113" ], "products": [ "species_29372", "species_83910" ], "modifiers": [ [ "species_10522938", "catalyst" ] ], "additional_components": [ "WBGene00022767" ] }, "reaction_10565621": { "compartment": "compartment_70101", "id": "reaction_10565621", "reactome": "R-CEL-8855062", "name": "SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2162252", "species_71284" ], "products": [ "species_2162265", "species_71285" ], "modifiers": [ [ "species_10565618", "catalyst" ] ], "additional_components": [ "WBGene00008364" ] }, "reaction_10566753": { "compartment": "compartment_876", "id": "reaction_10566753", "reactome": "R-CEL-8870354", "name": "SLC36A4 transports extracellular L-Pro to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352033" ], "products": [ "species_113538" ], "modifiers": [ [ "species_10566747", "catalyst" ] ], "additional_components": [ "O45936", "WBGene00012804", "O62286", "WBGene00010421", "P34479", "WBGene00010307", "Q18595", "WBGene00016628", "Q9XX44", "WBGene00012629", "G4SQY7", "WBGene00020837" ] }, "reaction_10519233": { "compartment": "compartment_876", "id": "reaction_10519233", "reactome": "R-CEL-375768", "name": "SLC7A2, isoform B (CAT-2B)-mediated uptake of cationic amino acids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_375765" ], "products": [ "species_375781" ], "modifiers": [ [ "species_10519230", "catalyst" ] ], "additional_components": [ "species_29444", "species_29468", "species_29468", "species_29444", "WBGene00013159" ] }, "reaction_10570181": { "compartment": "compartment_70101", "id": "reaction_10570181", "reactome": "R-CEL-8959781", "name": "SLC25A29 transports basic amino acids from cytosol to mitochondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8959777" ], "products": [ "species_8959775" ], "modifiers": [ [ "species_10570178", "catalyst" ] ], "additional_components": [ "CHEBI:28229", "species_29498", "species_29468", "species_29612", "species_29444", "CHEBI:27747", "species_29498", "species_29444", "species_29468", "species_29612", "CHEBI:28229", "CHEBI:27747", "WBGene00008320" ] }, "reaction_10519238": { "compartment": "compartment_876", "id": "reaction_10519238", "reactome": "R-CEL-375776", "name": "SLC7A1 (CAT-1)-mediated uptake of cationic amino acids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_375765" ], "products": [ "species_375781" ], "modifiers": [ [ "species_10519235", "catalyst" ] ], "additional_components": [ "species_29444", "species_29468", "species_29468", "species_29444", "WBGene00013159" ] }, "reaction_10519240": { "compartment": "compartment_876", "id": "reaction_10519240", "reactome": "R-CEL-375790", "name": "SLC7A2, isoform A (CAT-2A)-mediated uptake of cationic amino acids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_375765" ], "products": [ "species_375781" ], "modifiers": [ [ "species_10519230", "catalyst" ] ], "additional_components": [ "species_29444", "species_29468", "species_29468", "species_29444", "WBGene00013159" ] }, "reaction_10518156": { "compartment": "compartment_876", "id": "reaction_10518156", "reactome": "R-CEL-352379", "name": "SLC1A5-mediated exchange of alanine and glutamine across the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_83910", "species_352036", "species_29472", "species_74113" ], "products": [ "species_29432", "species_83910", "species_212615", "species_74113" ], "modifiers": [ [ "species_10518153", "catalyst" ] ], "additional_components": [ "Q21353", "WBGene00001621", "Q21751", "WBGene00001624", "Q22682", "WBGene00001622", "Q9UAY8", "WBGene00001625", "O18210", "WBGene00001623", "Q10901", "WBGene00001620" ] }, "reaction_10518133": { "compartment": "compartment_876", "id": "reaction_10518133", "reactome": "R-CEL-352347", "name": "SLC1A4-mediated exchange of extracellular serine for cytosolic alanine, threonine, or cysteine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352002", "species_83910", "species_352355", "species_74113" ], "products": [ "species_83910", "species_200736", "species_352359", "species_74113" ], "modifiers": [ [ "species_10518130", "catalyst" ] ], "additional_components": [ "species_200736", "species_351990", "species_29432", "species_111707", "species_29432", "species_351990", "species_111707", "species_200736", "Q9UAY8", "WBGene00001625", "O18210", "WBGene00001623", "Q10901", "WBGene00001620", "Q21353", "WBGene00001621", "Q21751", "WBGene00001624", "Q22682", "WBGene00001622" ] }, "reaction_10523018": { "compartment": "compartment_876", "id": "reaction_10523018", "reactome": "R-CEL-427998", "name": "Proton-coupled di- and tri-peptide cotransport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_428037" ], "products": [ "species_428026", "species_70106" ], "modifiers": [ [ "species_10523015", "catalyst" ] ], "additional_components": [ "CHEBI:90799", "CHEBI:47923", "CHEBI:47923", "CHEBI:90799", "WBGene00003876" ] }, "reaction_10523198": { "compartment": "compartment_201753", "id": "reaction_10523198", "reactome": "R-CEL-428625", "name": "Vesicular inhibitory amino acid transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428592", "species_428548" ], "products": [ "species_428632", "species_70106" ], "modifiers": [ [ "species_10523195", "catalyst" ] ], "additional_components": [ "species_159549", "species_352003", "species_352003", "species_159549", "WBGene00006783" ] }, "reaction_10565987": { "compartment": "compartment_876", "id": "reaction_10565987", "reactome": "R-CEL-8863494", "name": "ASICs bind STOML3, (STOM)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10565983", "species_10544954" ], "products": [ "species_10565985" ], "modifiers": [], "additional_components": [ "Q19958", "WBGene00006064", "Q20657", "WBGene00006065", "Q7YZV6", "WBGene00006067", "G3MU02", "WBGene00007775", "G5EGI5", "WBGene00001465", "species_70106", "G3MU02", "WBGene00007775", "G5EGI5", "WBGene00001465", "species_70106", "Q19958", "WBGene00006064", "Q20657", "WBGene00006065", "Q7YZV6", "WBGene00006067" ] }, "reaction_10544963": { "compartment": "compartment_70101", "id": "reaction_10544963", "reactome": "R-CEL-2671885", "name": "ASIC trimers:H+ transport extracellular Na+ to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74113" ], "products": [ "species_83910" ], "modifiers": [ [ "species_10544954", "catalyst" ], [ "species_2672379", "inhibitor" ], [ "species_2672383", "inhibitor" ], [ "species_10544961", "inhibitor" ] ], "additional_components": [ "G3MU02", "WBGene00007775", "G5EGI5", "WBGene00001465", "species_70106", "G3MU02", "WBGene00007775", "G5EGI5", "WBGene00001465" ] }, "reaction_10545603": { "compartment": "compartment_70101", "id": "reaction_10545603", "reactome": "R-CEL-2744242", "name": "TTYH2/3 transport cytosolic Cl- to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352022" ], "products": [ "species_188972" ], "modifiers": [ [ "species_10545598", "catalyst" ], [ "species_74016", "catalyst" ] ], "additional_components": [ "WBGene00009632" ] }, "reaction_10545477": { "compartment": "compartment_70101", "id": "reaction_10545477", "reactome": "R-CEL-2730692", "name": "CLCN4/5/6 exchange Cl- for H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_2731008" ], "products": [ "species_74722", "species_352022" ], "modifiers": [ [ "species_10545472", "catalyst" ] ], "additional_components": [ "WBGene00000532" ] }, "reaction_10545608": { "compartment": "compartment_70101", "id": "reaction_10545608", "reactome": "R-CEL-2744349", "name": "TTYH1 transports cytosolic Cl- to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352022" ], "products": [ "species_188972" ], "modifiers": [ [ "species_10545605", "catalyst" ] ], "additional_components": [ "WBGene00009632" ] }, "reaction_10573259": { "compartment": "compartment_70101", "id": "reaction_10573259", "reactome": "R-CEL-9701141", "name": "TRPV1 transports Ca2+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74112" ], "products": [ "species_74016" ], "modifiers": [ [ "species_10547087", "catalyst" ] ], "additional_components": [ "WBGene00003889" ] }, "reaction_10547102": { "compartment": "compartment_70101", "id": "reaction_10547102", "reactome": "R-CEL-3295579", "name": "TRPs transport extracellular Ca2+ to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74112" ], "products": [ "species_74016" ], "modifiers": [ [ "species_10547099", "catalyst" ] ], "additional_components": [ "G5ECM4", "WBGene00001795", "P34641", "WBGene00000425", "Q20766", "WBGene00001796", "Q93971", "WBGene00001651", "Q8T666", "WBGene00000846", "Q8I6Y9", "WBGene00006615", "Q19377", "WBGene00008731", "Q23141", "WBGene00020972", "G5EE29", "WBGene00021404", "P91448", "WBGene00004149", "G5EBV8", "WBGene00003889" ] }, "reaction_10547119": { "compartment": "compartment_70101", "id": "reaction_10547119", "reactome": "R-CEL-3295580", "name": "TRPM4,5 transport extracellular Na+ to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74113" ], "products": [ "species_83910" ], "modifiers": [ [ "species_10547116", "catalyst" ] ], "additional_components": [ "Q19377", "WBGene00008731", "G5EE29", "WBGene00021404", "P91448", "WBGene00004149", "Q23141", "WBGene00020972" ] }, "reaction_10572715": { "compartment": "compartment_876", "id": "reaction_10572715", "reactome": "R-CEL-9650165", "name": "ASIC trimers bind H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_10572713" ], "products": [ "species_10544954" ], "modifiers": [], "additional_components": [ "G3MU02", "WBGene00007775", "G5EGI5", "WBGene00001465", "G3MU02", "WBGene00007775", "G5EGI5", "WBGene00001465", "species_70106" ] }, "reaction_10545454": { "compartment": "compartment_70101", "id": "reaction_10545454", "reactome": "R-CEL-2682349", "name": "RAF1:SGK:TSC22D3:WPP ubiquitinates SCNN channels", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10545262", "species_113592", "species_10502375" ], "products": [ "species_29370", "species_947590", "species_10545415" ], "modifiers": [ [ "species_10545440", "catalyst" ], [ "species_10545446", "catalyst" ] ], "additional_components": [ "P24612", "WBGene00003168", "Q21974", "WBGene00006748", "P34886", "WBGene00003174", "Q22851", "WBGene00012137", "P91100", "WBGene00016066", "Q22970", "WBGene00017879", "P91102", "WBGene00016064", "Q8MPW0", "WBGene00011891", "P91103", "WBGene00016063", "Q93205", "WBGene00007518", "P91835", "WBGene00012116", "Q9U1T8", "WBGene00013487", "Q09274", "WBGene00006832", "Q9U1T9", "WBGene00013486", "Q10025", "WBGene00020897", "Q9XTS9", "WBGene00013480", "G5EFH3", "WBGene00010334", "Q18077", "WBGene00015957", "O01635", "WBGene00022815", "Q18651", "WBGene00016699", "O01664", "WBGene00020903", "Q19038", "WBGene00000952", "O45402", "WBGene00009073", "Q19777", "WBGene00009109", "P24585", "WBGene00000950", "Q20852", "WBGene00018906", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "P91103", "WBGene00016063", "P91835", "WBGene00012116", "Q09274", "WBGene00006832", "Q10025", "WBGene00020897", "Q18077", "WBGene00015957", "Q18651", "WBGene00016699", "Q19038", "WBGene00000952", "Q19777", "WBGene00009109", "Q20852", "WBGene00018906", "Q21974", "WBGene00006748", "Q22851", "WBGene00012137", "Q22970", "WBGene00017879", "Q8MPW0", "WBGene00011891", "Q93205", "WBGene00007518", "Q9U1T8", "WBGene00013487", "Q9U1T9", "WBGene00013486", "Q9XTS9", "WBGene00013480", "G5EFH3", "WBGene00010334", "O01635", "WBGene00022815", "O01664", "WBGene00020903", "O45402", "WBGene00009073", "P24585", "WBGene00000950", "P24612", "WBGene00003168", "P34886", "WBGene00003174", "P91100", "WBGene00016066", "P91102", "WBGene00016064", "A0A061ACQ8", "WBGene00022358", "Q9N2Z7", "WBGene00007009", "Q2PJ68", "WBGene00004789", "H2KYK3", "WBGene00016269", "Q9U290", "WBGene00016269", "Q07292", "WBGene00003030", "WBGene00006941" ] }, "reaction_10545550": { "compartment": "compartment_70101", "id": "reaction_10545550", "reactome": "R-CEL-2730959", "name": "CLCN7:OSTM1 exchanges Cl- for H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2730999", "species_70106" ], "products": [ "species_428040", "species_352022" ], "modifiers": [ [ "species_10545547", "catalyst" ] ], "additional_components": [ "G5EC75", "WBGene00000533", "Q09322", "WBGene00009627" ] }, "reaction_10545265": { "compartment": "compartment_984", "id": "reaction_10545265", "reactome": "R-CEL-2672334", "name": "SCNN channels transport extracellular Na+ to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74113" ], "products": [ "species_83910" ], "modifiers": [ [ "species_10545262", "catalyst" ], [ "species_2672379", "inhibitor" ] ], "additional_components": [ "P24612", "WBGene00003168", "Q21974", "WBGene00006748", "P34886", "WBGene00003174", "Q22851", "WBGene00012137", "P91100", "WBGene00016066", "Q22970", "WBGene00017879", "P91102", "WBGene00016064", "Q8MPW0", "WBGene00011891", "P91103", "WBGene00016063", "Q93205", "WBGene00007518", "P91835", "WBGene00012116", "Q9U1T8", "WBGene00013487", "Q09274", "WBGene00006832", "Q9U1T9", "WBGene00013486", "Q10025", "WBGene00020897", "Q9XTS9", "WBGene00013480", "G5EFH3", "WBGene00010334", "Q18077", "WBGene00015957", "O01635", "WBGene00022815", "Q18651", "WBGene00016699", "O01664", "WBGene00020903", "Q19038", "WBGene00000952", "O45402", "WBGene00009073", "Q19777", "WBGene00009109", "P24585", "WBGene00000950", "Q20852", "WBGene00018906" ] }, "reaction_10545970": { "compartment": "compartment_984", "id": "reaction_10545970", "reactome": "R-CEL-2872444", "name": "SLC9B1/C2 exchange Na+ for H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_74113" ], "products": [ "species_351626", "species_83910" ], "modifiers": [ [ "species_10545967", "catalyst" ] ], "additional_components": [ "G5EFS0", "WBGene00009618", "Q20273", "WBGene00009617", "Q9XU88", "WBGene00010214" ] }, "reaction_10545907": { "compartment": "compartment_70101", "id": "reaction_10545907", "reactome": "R-CEL-2744361", "name": "BESTs transport cytosolic Cl- to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352022" ], "products": [ "species_188972" ], "modifiers": [ [ "species_10545904", "catalyst" ], [ "species_74016", "catalyst" ] ], "additional_components": [ "O17206", "WBGene00015286", "Q18303", "WBGene00007808", "O17671", "WBGene00008186", "Q19978", "WBGene00009340", "O18303", "WBGene00014102", "Q21973", "WBGene00011258", "O18304", "WBGene00014103", "Q22566", "WBGene00020559", "O45363", "WBGene00008821", "Q23369", "WBGene00013921", "O45435", "WBGene00009323", "Q7YXH3", "WBGene00020046", "O62095", "WBGene00007988", "Q94175", "WBGene00016613", "P34319", "WBGene00007404", "Q965X4", "WBGene00021368", "P34577", "WBGene00011868", "Q9NA59", "WBGene00013520", "A5JYR2", "WBGene00014989", "P34672", "WBGene00022797", "J7RNL4", "WBGene00220250", "Q17528", "WBGene00007203", "O16779", "WBGene00206487", "Q17529", "WBGene00007204", "O17205", "WBGene00015288", "Q17851", "WBGene00015628" ] }, "reaction_10545975": { "compartment": "compartment_17927", "id": "reaction_10545975", "reactome": "R-CEL-2889070", "name": "SLC9B2 exchanges Na+, Li+ for H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113529", "species_2889081" ], "products": [ "species_2889062", "species_163953" ], "modifiers": [ [ "species_10545972", "catalyst" ] ], "additional_components": [ "species_83910", "species_425810", "species_425810", "species_83910", "WBGene00009617" ] }, "reaction_10545593": { "compartment": "compartment_70101", "id": "reaction_10545593", "reactome": "R-CEL-2744228", "name": "CLCN1/2/KA/KB transport cytosolic Cl- to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352022" ], "products": [ "species_188972" ], "modifiers": [ [ "species_10545590", "catalyst" ] ], "additional_components": [ "Q9BMK9", "WBGene00000530", "G5EG93", "WBGene00000529", "H2L0J1", "WBGene00000531", "Q22833", "WBGene00000528" ] }, "reaction_10545467": { "compartment": "compartment_70101", "id": "reaction_10545467", "reactome": "R-CEL-2684901", "name": "ANOs transport cytosolic Cl- to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352022" ], "products": [ "species_188972" ], "modifiers": [ [ "species_10545464", "catalyst" ], [ "species_74016", "catalyst" ] ], "additional_components": [ "WBGene00013326" ] }, "reaction_10545916": { "compartment": "compartment_70101", "id": "reaction_10545916", "reactome": "R-CEL-2752067", "name": "BESTs transport cytosolic HCO3- to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111627" ], "products": [ "species_425425" ], "modifiers": [ [ "species_10545904", "catalyst" ] ], "additional_components": [ "O17206", "WBGene00015286", "Q18303", "WBGene00007808", "O17671", "WBGene00008186", "Q19978", "WBGene00009340", "O18303", "WBGene00014102", "Q21973", "WBGene00011258", "O18304", "WBGene00014103", "Q22566", "WBGene00020559", "O45363", "WBGene00008821", "Q23369", "WBGene00013921", "O45435", "WBGene00009323", "Q7YXH3", "WBGene00020046", "O62095", "WBGene00007988", "Q94175", "WBGene00016613", "P34319", "WBGene00007404", "Q965X4", "WBGene00021368", "P34577", "WBGene00011868", "Q9NA59", "WBGene00013520", "A5JYR2", "WBGene00014989", "P34672", "WBGene00022797", "J7RNL4", "WBGene00220250", "Q17528", "WBGene00007203", "O16779", "WBGene00206487", "Q17529", "WBGene00007204", "O17205", "WBGene00015288", "Q17851", "WBGene00015628" ] }, "reaction_10529392": { "compartment": "compartment_20699", "id": "reaction_10529392", "reactome": "R-CEL-936883", "name": "ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_74016" ], "products": [ "species_29372", "species_29370", "species_167012" ], "modifiers": [ [ "species_10529389", "catalyst" ] ], "additional_components": [ "species_114632", "G5EDU1", "WBGene00004063" ] }, "reaction_10523009": { "compartment": "compartment_12045", "id": "reaction_10523009", "reactome": "R-CEL-427910", "name": "ATP2A1-3 transport Ca2+ from cytosol to ER lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_156540", "species_74016" ], "products": [ "species_70106", "species_111875" ], "modifiers": [ [ "species_10522985", "catalyst" ], [ "species_10523007", "catalyst" ] ], "additional_components": [ "WBGene00004736", "species_74016", "Q11083", "WBGene00020378", "P04630", "WBGene00000285", "G5EF37", "WBGene00003934", "A0A2C9C3L3", "WBGene00020378", "Q18136", "WBGene00006861", "Q09665", "WBGene00006583", "O02159", "WBGene00020378", "G5EDZ8", "WBGene00000288", "Q94288", "WBGene00000287", "Q09980", "WBGene00017394", "O16305", "WBGene00000552", "G5EEG0", "WBGene00000286", "O62305", "WBGene00006779" ] }, "reaction_10529571": { "compartment": "compartment_70101", "id": "reaction_10529571", "reactome": "R-CEL-947591", "name": "P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_947588", "species_113592" ], "products": [ "species_29372", "species_29370", "species_947594" ], "modifiers": [ [ "species_10529510", "catalyst" ] ], "additional_components": [ "species_33625", "species_8959490", "species_8959490", "species_33625", "O18182", "WBGene00012360", "Q7JPE3", "WBGene00020784", "Q9U280", "WBGene00013034", "U4PBV8", "WBGene00019166" ] }, "reaction_10556898": { "compartment": "compartment_70101", "id": "reaction_10556898", "reactome": "R-CEL-5692462", "name": "ATP13A1 transports Mn2+ from cytosol to ER lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_29418", "species_113592" ], "products": [ "species_29372", "species_29370", "species_1981162" ], "modifiers": [ [ "species_10556895", "catalyst" ] ], "additional_components": [ "WBGene00007514" ] }, "reaction_10556918": { "compartment": "compartment_70101", "id": "reaction_10556918", "reactome": "R-CEL-5692480", "name": "ATP13A2 transports cations from cytosol to lysosomal lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_5692450" ], "products": [ "species_29372", "species_29370", "species_5692484" ], "modifiers": [ [ "species_10556915", "catalyst" ] ], "additional_components": [ "Q9N323", "WBGene00022010", "Q21286", "WBGene00019493", "Q27533", "WBGene00012341" ] }, "reaction_10529455": { "compartment": "compartment_876", "id": "reaction_10529455", "reactome": "R-CEL-937311", "name": "ATP4A/12A:ATP4B exchanges K+ for H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74126", "species_29356", "species_70106", "species_113592" ], "products": [ "species_351626", "species_29804", "species_29372", "species_29370" ], "modifiers": [ [ "species_10529452", "catalyst" ] ], "additional_components": [ "O16331", "WBGene00015660", "O16436", "WBGene00015338", "P90735", "WBGene00001137", "G5EBE7", "WBGene00013672", "G5EFV6", "WBGene00007248", "Q9XUG9", "WBGene00008074", "Q9XUY5", "WBGene00010117", "Q93235", "WBGene00007646" ] }, "reaction_10565635": { "compartment": "compartment_876", "id": "reaction_10565635", "reactome": "R-CEL-8855130", "name": "VLDLR:PCSK9:Clathrin-coated vesicle translocates from the plasma membrane to lysosomal membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10565625" ], "products": [ "species_10565633" ], "modifiers": [], "additional_components": [ "P34574", "WBGene00011867", "P90961", "WBGene00020246", "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q04833", "WBGene00003071", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "Q9N4F3", "WBGene00000160", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q22601", "WBGene00000161", "Q04833", "WBGene00003071" ] }, "reaction_10567491": { "compartment": "compartment_161320", "id": "reaction_10567491", "reactome": "R-CEL-8876472", "name": "NPC2 binds CHOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10567487", "species_8848047" ], "products": [ "species_10567489" ], "modifiers": [], "additional_components": [ "WBGene00006452", "species_193384", "O17271", "WBGene00006452" ] }, "reaction_10511510": { "compartment": "compartment_74700", "id": "reaction_10511510", "reactome": "R-CEL-171087", "name": "LDLR [endosome membrane] => LDLR [plasma membrane]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10511502" ], "products": [ "species_10511508" ], "modifiers": [], "additional_components": [ "O01768", "WBGene00003072", "Q04833", "WBGene00003071", "O01768", "WBGene00003072", "Q04833", "WBGene00003071" ] }, "reaction_10567497": { "compartment": "compartment_161320", "id": "reaction_10567497", "reactome": "R-CEL-8876484", "name": "NPC2 transfers CHOL to NPC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10567493", "species_10567489" ], "products": [ "species_10567487", "species_10567495" ], "modifiers": [], "additional_components": [ "WBGene00003562", "species_193384", "O17271", "WBGene00006452", "WBGene00006452", "P34389", "WBGene00003562", "species_193384" ] }, "reaction_10567499": { "compartment": "compartment_12045", "id": "reaction_10567499", "reactome": "R-CEL-8876485", "name": "CHOL translocates from lysosome membrane to ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10567495" ], "products": [ "species_193384", "species_10567493" ], "modifiers": [], "additional_components": [ "P34389", "WBGene00003562", "species_193384", "WBGene00003562" ] }, "reaction_10558091": { "compartment": "compartment_1660541", "id": "reaction_10558091", "reactome": "R-CEL-6784729", "name": "PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10558057" ], "products": [ "species_10558089" ], "modifiers": [], "additional_components": [ "P34574", "WBGene00011867", "P90961", "WBGene00020246", "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "O01768", "WBGene00003072", "Q04833", "WBGene00003071", "O01768", "WBGene00003072", "Q04833", "WBGene00003071", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "Q9N4F3", "WBGene00000160", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q22601", "WBGene00000161" ] }, "reaction_10567546": { "compartment": "compartment_12045", "id": "reaction_10567546", "reactome": "R-CEL-8876696", "name": "SOAT1,2 transfer acyl group to CHOL forming CHEST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193384", "species_1500578" ], "products": [ "species_8876704", "species_76194" ], "modifiers": [ [ "species_10567541", "catalyst" ] ], "additional_components": [ "WBGene00007174" ] }, "reaction_10558093": { "compartment": "compartment_1660541", "id": "reaction_10558093", "reactome": "R-CEL-6784738", "name": "Degradation of PCSK9:LDLR:Clathrin-coated vesicle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10558089" ], "products": [ "species_10558087" ], "modifiers": [], "additional_components": [ "O01768", "WBGene00003072", "Q04833", "WBGene00003071", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "Q9N4F3", "WBGene00000160", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q22601", "WBGene00000161", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "Q9N4F3", "WBGene00000160", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q22601", "WBGene00000161" ] }, "reaction_10564126": { "compartment": "compartment_70101", "id": "reaction_10564126", "reactome": "R-CEL-6813720", "name": "NCEH1 hydrolyzes cholesterol esters", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_163579" ], "products": [ "species_8876730", "species_216762" ], "modifiers": [ [ "species_10564123", "catalyst" ] ], "additional_components": [ "Q19839", "WBGene00009186", "Q7JMM5", "WBGene00017515", "Q94187", "WBGene00017515", "Q9XWL5", "WBGene00012810" ] }, "reaction_10511233": { "compartment": "compartment_70101", "id": "reaction_10511233", "reactome": "R-CEL-170126", "name": "Phosphorylation of Cyclin B1 in the CRS domain", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10511226", "species_113592" ], "products": [ "species_29370", "species_10511126" ], "modifiers": [ [ "species_10511230", "catalyst" ] ], "additional_components": [ "Q10653", "WBGene00000865", "Q9BLB5", "WBGene00000867", "O45926", "WBGene00000866", "P34556", "WBGene00000405", "Q9BLB5", "WBGene00000867", "O45926", "WBGene00000866", "Q10653", "WBGene00000865", "P34556", "WBGene00000405" ] }, "reaction_10565795": { "compartment": "compartment_7660", "id": "reaction_10565795", "reactome": "R-CEL-8856945", "name": "PP2A methylation by LCMT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10533066" ], "products": [ "species_77502", "species_10565787" ], "modifiers": [ [ "species_10565792", "catalyst" ] ], "additional_components": [ "WBGene00007137" ] }, "reaction_10511235": { "compartment": "compartment_13231", "id": "reaction_10511235", "reactome": "R-CEL-170131", "name": "Translocation of CRS phosphorylated Cyclin B1:Cdc2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10511126" ], "products": [ "species_10511156" ], "modifiers": [], "additional_components": [ "Q9BLB5", "WBGene00000867", "O45926", "WBGene00000866", "Q10653", "WBGene00000865", "P34556", "WBGene00000405", "O45926", "WBGene00000866", "Q10653", "WBGene00000865", "Q9BLB5", "WBGene00000867", "P34556", "WBGene00000405" ] }, "reaction_10511269": { "compartment": "compartment_70101", "id": "reaction_10511269", "reactome": "R-CEL-170161", "name": "Dephosphorylation of cytoplasmic Cyclin B1/B2:phospho-Cdc2 (Thr 14, Tyr 15) complexes by CDC25B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10511262", "species_29356" ], "products": [ "species_29372", "species_10511266" ], "modifiers": [ [ "species_10511222", "catalyst" ] ], "additional_components": [ "Q10653", "WBGene00000865", "Q9BLB5", "WBGene00000867", "O45926", "WBGene00000866", "P34556", "WBGene00000405", "Q10653", "WBGene00000865", "P34556", "WBGene00000405", "Q9BLB5", "WBGene00000867", "O45926", "WBGene00000866", "WBGene00000389" ] }, "reaction_10511239": { "compartment": "compartment_13231", "id": "reaction_10511239", "reactome": "R-CEL-170149", "name": "Translocation of active Cdc25C to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509859" ], "products": [ "species_10511237" ], "modifiers": [], "additional_components": [ "WBGene00000389", "WBGene00000389" ] }, "reaction_10511175": { "compartment": "compartment_70101", "id": "reaction_10511175", "reactome": "R-CEL-170055", "name": "Myt-1 mediated phosphorylation of Cyclin B:Cdc2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10511168" ], "products": [ "species_29370", "species_10511170" ], "modifiers": [ [ "species_10511172", "catalyst" ] ], "additional_components": [ "Q10653", "WBGene00000865", "Q9BLB5", "WBGene00000867", "O45926", "WBGene00000866", "P34556", "WBGene00000405", "P34556", "WBGene00000405", "Q10653", "WBGene00000865", "Q9BLB5", "WBGene00000867", "O45926", "WBGene00000866", "WBGene00006940" ] }, "reaction_10511208": { "compartment": "compartment_70101", "id": "reaction_10511208", "reactome": "R-CEL-170084", "name": "Formation of Cyclin A:Cdc2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10511166", "species_10511204" ], "products": [ "species_10511206" ], "modifiers": [], "additional_components": [ "WBGene00000405", "P34556", "WBGene00000405" ] }, "reaction_10511177": { "compartment": "compartment_70101", "id": "reaction_10511177", "reactome": "R-CEL-170057", "name": "Formation of Cyclin B:Cdc2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10511166", "species_10511164" ], "products": [ "species_10511168" ], "modifiers": [], "additional_components": [ "WBGene00000405", "Q10653", "WBGene00000865", "Q9BLB5", "WBGene00000867", "O45926", "WBGene00000866", "Q10653", "WBGene00000865", "Q9BLB5", "WBGene00000867", "O45926", "WBGene00000866", "P34556", "WBGene00000405" ] }, "reaction_10565803": { "compartment": "compartment_7660", "id": "reaction_10565803", "reactome": "R-CEL-8856951", "name": "PP2A demethylation by PPME1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10565787" ], "products": [ "species_10533066", "species_8857797" ], "modifiers": [ [ "species_10565800", "catalyst" ] ], "additional_components": [ "WBGene00007188" ] }, "reaction_10511214": { "compartment": "compartment_7660", "id": "reaction_10511214", "reactome": "R-CEL-170087", "name": "CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10511210" ], "products": [ "species_113582", "species_10511212" ], "modifiers": [ [ "species_10506279", "catalyst" ] ], "additional_components": [ "P34556", "WBGene00000405", "P34556", "WBGene00000405", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408" ] }, "reaction_10511246": { "compartment": "compartment_7660", "id": "reaction_10511246", "reactome": "R-CEL-170153", "name": "Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10511144" ], "products": [ "species_113550", "species_10511241" ], "modifiers": [ [ "species_10511243", "catalyst" ] ], "additional_components": [ "O45926", "WBGene00000866", "Q10653", "WBGene00000865", "Q9BLB5", "WBGene00000867", "P34556", "WBGene00000405", "O45926", "WBGene00000866", "Q10653", "WBGene00000865", "Q9BLB5", "WBGene00000867", "P34556", "WBGene00000405", "Q21762", "WBGene00000389" ] }, "reaction_10511218": { "compartment": "compartment_13231", "id": "reaction_10511218", "reactome": "R-CEL-170088", "name": "Translocation of Cyclin A:phospho-Cdc2 (Thr 14) to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10511216" ], "products": [ "species_10511210" ], "modifiers": [], "additional_components": [ "P34556", "WBGene00000405", "P34556", "WBGene00000405" ] }, "reaction_10511252": { "compartment": "compartment_7660", "id": "reaction_10511252", "reactome": "R-CEL-170158", "name": "Dephosphorylation of nuclear Cyclin A:phospho-Cdc2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10511248" ], "products": [ "species_113550", "species_10511250" ], "modifiers": [ [ "species_10502759", "catalyst" ] ], "additional_components": [ "P34556", "WBGene00000405", "P34556", "WBGene00000405", "WBGene00000389" ] }, "reaction_10511188": { "compartment": "compartment_13231", "id": "reaction_10511188", "reactome": "R-CEL-170072", "name": "Translocation of Cyclin B1:phospho-Cdc2 to the cytoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10511144" ], "products": [ "species_10511104" ], "modifiers": [ [ "species_10511186", "catalyst" ] ], "additional_components": [ "O45926", "WBGene00000866", "Q10653", "WBGene00000865", "Q9BLB5", "WBGene00000867", "P34556", "WBGene00000405", "Q10653", "WBGene00000865", "Q9BLB5", "WBGene00000867", "O45926", "WBGene00000866", "P34556", "WBGene00000405", "WBGene00002078" ] }, "reaction_10511160": { "compartment": "compartment_13231", "id": "reaction_10511160", "reactome": "R-CEL-170044", "name": "Translocation of Cyclin B1:phospho-Cdc2 complexes to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10511128" ], "products": [ "species_10511158" ], "modifiers": [], "additional_components": [ "Q10653", "WBGene00000865", "Q9BLB5", "WBGene00000867", "O45926", "WBGene00000866", "P34556", "WBGene00000405", "O45926", "WBGene00000866", "Q10653", "WBGene00000865", "Q9BLB5", "WBGene00000867", "P34556", "WBGene00000405" ] }, "reaction_10511192": { "compartment": "compartment_7660", "id": "reaction_10511192", "reactome": "R-CEL-170076", "name": "CAK-mediated phosphorylation of Cyclin B1:Cdc2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10511140" ], "products": [ "species_113582", "species_10511181" ], "modifiers": [ [ "species_10506279", "catalyst" ] ], "additional_components": [ "O45926", "WBGene00000866", "Q10653", "WBGene00000865", "Q9BLB5", "WBGene00000867", "P34556", "WBGene00000405", "O45926", "WBGene00000866", "Q10653", "WBGene00000865", "Q9BLB5", "WBGene00000867", "P34556", "WBGene00000405", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408" ] }, "reaction_10511224": { "compartment": "compartment_13231", "id": "reaction_10511224", "reactome": "R-CEL-170120", "name": "Translocation of Cdc25B to the cytoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10511220" ], "products": [ "species_10511222" ], "modifiers": [], "additional_components": [ "WBGene00000389", "WBGene00000389" ] }, "reaction_10511258": { "compartment": "compartment_13231", "id": "reaction_10511258", "reactome": "R-CEL-170159", "name": "Translocation of Cdc25 to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10511256" ], "products": [ "species_10511243" ], "modifiers": [], "additional_components": [ "Q21762", "WBGene00000389", "Q21762", "WBGene00000389" ] }, "reaction_10546257": { "compartment": "compartment_70101", "id": "reaction_10546257", "reactome": "R-CEL-3002798", "name": "Cytosolic PLK1 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509861" ], "products": [ "species_10509851" ], "modifiers": [], "additional_components": [ "WBGene00004043", "WBGene00004043" ] }, "reaction_10546277": { "compartment": "compartment_7660", "id": "reaction_10546277", "reactome": "R-CEL-3002811", "name": "Myosin phosphatase dephosphorylates PLK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10509851" ], "products": [ "species_113550", "species_10546259" ], "modifiers": [ [ "species_10546274", "catalyst" ] ], "additional_components": [ "WBGene00004043", "WBGene00004043", "Q27497", "WBGene00001747", "G5ECD7", "WBGene00003196" ] }, "reaction_10548983": { "compartment": "compartment_70101", "id": "reaction_10548983", "reactome": "R-CEL-4086410", "name": "CDK1 phosphorylates BORA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10548981" ], "products": [ "species_29370", "species_10546195" ], "modifiers": [ [ "species_10511266", "catalyst" ] ], "additional_components": [ "WBGene00010198", "WBGene00010198", "Q10653", "WBGene00000865", "P34556", "WBGene00000405", "Q9BLB5", "WBGene00000867", "O45926", "WBGene00000866" ] }, "reaction_10546204": { "compartment": "compartment_70101", "id": "reaction_10546204", "reactome": "R-CEL-3000327", "name": "PLK1 phosphorylates BORA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10546197" ], "products": [ "species_29370", "species_10546201", "species_10509861" ], "modifiers": [ [ "species_10546197", "catalyst" ] ], "additional_components": [ "H2FLK2", "WBGene00010198", "Q9N2L7", "WBGene00004043", "WBGene00010198", "WBGene00004043", "H2FLK2", "WBGene00010198", "Q9N2L7", "WBGene00004043" ] }, "reaction_10565466": { "compartment": "compartment_70101", "id": "reaction_10565466", "reactome": "R-CEL-8854041", "name": "SCF-FBXL7 ubiquitinates AURKA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10565421", "species_10502375" ], "products": [ "species_10565463" ], "modifiers": [ [ "species_10565421", "catalyst" ] ], "additional_components": [ "G5ECU1", "WBGene00004807", "Q17389", "WBGene00000836", "Q23457", "WBGene00004320", "O01427", "WBGene00000099", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "O01427", "WBGene00000099", "G5ECU1", "WBGene00004807", "Q17389", "WBGene00000836", "Q23457", "WBGene00004320", "G5ECU1", "WBGene00004807", "Q17389", "WBGene00000836", "Q23457", "WBGene00004320", "O01427", "WBGene00000099" ] }, "reaction_10565468": { "compartment": "compartment_70101", "id": "reaction_10565468", "reactome": "R-CEL-8854044", "name": "Proteasome degrades AURKA ubiquitinated by SCF-FBXL7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10565463" ], "products": [ "species_10502375", "species_10565414" ], "modifiers": [ [ "species_10502572", "catalyst" ] ], "additional_components": [ "O01427", "WBGene00000099", "G5ECU1", "WBGene00004807", "Q17389", "WBGene00000836", "Q23457", "WBGene00004320", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "G5ECU1", "WBGene00004807", "Q17389", "WBGene00000836", "Q23457", "WBGene00004320", "P91477", "WBGene00003950", "Q95PZ7", "WBGene00013435", "Q18115", "WBGene00004459", "O62102", "WBGene00003948", "O17071", "WBGene00004504", "Q10920", "WBGene00016623", "P34286", "WBGene00003952", "Q9XTT9", "WBGene00004506", "Q23449", "WBGene00004468", "Q95005", "WBGene00003925", "P46502", "WBGene00004503", "O61792", "WBGene00004464", "O17586", "WBGene00003922", "O76371", "WBGene00004505", "Q20585", "WBGene00004463", "Q95008", "WBGene00003926", "Q18787", "WBGene00004501", "Q20058", "WBGene00009445", "Q9N599", "WBGene00003924", "O16368", "WBGene00004502", "O61742", "WBGene00004466", "Q09583", "WBGene00003928", "Q966I8", "WBGene00003947", "Q04908", "WBGene00004460", "Q9XUV0", "WBGene00003951", "Q27488", "WBGene00003923", "Q9GZH5", "WBGene00004458", "O44156", "WBGene00003927", "Q22253", "WBGene00004465", "O76577", "WBGene00004467", "P90868", "WBGene00003953", "Q19324", "WBGene00004461", "Q17971", "WBGene00007588", "Q23237", "WBGene00003949", "Q20938", "WBGene00004462" ] }, "reaction_10565423": { "compartment": "compartment_70101", "id": "reaction_10565423", "reactome": "R-CEL-8853496", "name": "SCF:FBXL7 binds AURKA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10565419", "species_10565414" ], "products": [ "species_10565421" ], "modifiers": [], "additional_components": [ "WBGene00000099", "G5ECU1", "WBGene00004807", "Q17389", "WBGene00000836", "Q23457", "WBGene00004320", "G5ECU1", "WBGene00004807", "Q17389", "WBGene00000836", "Q23457", "WBGene00004320", "O01427", "WBGene00000099" ] }, "reaction_10565570": { "compartment": "compartment_20699", "id": "reaction_10565570", "reactome": "R-CEL-8854303", "name": "TBC1D11 binds RAB6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10565566", "species_10564844" ], "products": [ "species_10565568" ], "modifiers": [], "additional_components": [ "WBGene00018075", "Q22782", "WBGene00004270", "P34213", "WBGene00004269", "species_29438", "Q22782", "WBGene00004270", "P34213", "WBGene00004269", "species_29438", "H2KZZ6", "WBGene00018075" ] }, "reaction_10565591": { "compartment": "compartment_5683628", "id": "reaction_10565591", "reactome": "R-CEL-8854612", "name": "TBC1D25 accelerates GTP hydrolysis by RAB33B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10565586" ], "products": [ "species_29372", "species_10565588" ], "modifiers": [ [ "species_10565586", "catalyst" ] ], "additional_components": [ "species_29438", "Q20365", "WBGene00004283", "species_29420", "Q20365", "WBGene00004283", "species_29438", "Q20365", "WBGene00004283" ] }, "reaction_10565561": { "compartment": "compartment_262783", "id": "reaction_10565561", "reactome": "R-CEL-8854293", "name": "TBC1D10A (EPI64) binds ARF6:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10565550", "species_10565557" ], "products": [ "species_10565559" ], "modifiers": [], "additional_components": [ "WBGene00019915", "Q9U2S4", "WBGene00000184", "species_29438", "Q9U2S4", "WBGene00000184", "species_29438", "O44873", "WBGene00019915" ] }, "reaction_10565576": { "compartment": "compartment_17938", "id": "reaction_10565576", "reactome": "R-CEL-8854329", "name": "TBC1D15 accelerates GTP hydrolysis by RAB7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10565537" ], "products": [ "species_29372", "species_10565574" ], "modifiers": [ [ "species_10565537", "catalyst" ] ], "additional_components": [ "species_29438", "Q23146", "WBGene00004271", "species_29420", "Q23146", "WBGene00004271", "species_29438", "Q23146", "WBGene00004271" ] }, "reaction_10565547": { "compartment": "compartment_17938", "id": "reaction_10565547", "reactome": "R-CEL-8854255", "name": "TBC1D2A accelerates GTP hydrolysis by RAB7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10565537" ], "products": [ "species_29372", "species_10565539" ], "modifiers": [ [ "species_10565537", "catalyst" ], [ "species_10565545", "catalyst" ] ], "additional_components": [ "species_29438", "Q23146", "WBGene00004271", "species_29420", "Q23146", "WBGene00004271", "species_29438", "Q23146", "WBGene00004271", "WBGene00007849" ] }, "reaction_10565498": { "compartment": "compartment_24339", "id": "reaction_10565498", "reactome": "R-CEL-8854173", "name": "TBC RabGAPs accelerate GTP hydrolysis by RAB35", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10565475" ], "products": [ "species_29372", "species_10565477" ], "modifiers": [ [ "species_10565475", "catalyst" ], [ "species_10565496", "catalyst" ] ], "additional_components": [ "Q9U2C3", "WBGene00004284", "species_29438", "Q9U2C3", "WBGene00004284", "species_29420", "Q9U2C3", "WBGene00004284", "species_29438", "Q20436", "WBGene00009726", "H2KZ54", "WBGene00016292", "O44873", "WBGene00019915" ] }, "reaction_10565533": { "compartment": "compartment_171062", "id": "reaction_10565533", "reactome": "R-CEL-8854222", "name": "TBC1D3 associates with RAB5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10565501", "species_10565529" ], "products": [ "species_10565531" ], "modifiers": [], "additional_components": [ "WBGene00012894", "P91857", "WBGene00004268", "species_29438", "Q23165", "WBGene00000166", "A0A486WY48", "WBGene00012644", "P91857", "WBGene00004268", "species_29438", "Q23165", "WBGene00000166", "A0A486WY48", "WBGene00012644", "Q9U2D8", "WBGene00012894" ] }, "reaction_10565613": { "compartment": "compartment_262783", "id": "reaction_10565613", "reactome": "R-CEL-8854759", "name": "TBC1D14 binds RAB11 and ULK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10565609", "species_10565604", "species_10565602" ], "products": [ "species_10565611" ], "modifiers": [], "additional_components": [ "WBGene00044061", "WBGene00006786", "WBGene00004274", "O01803", "WBGene00004274", "Q23023", "WBGene00006786", "Q21928", "WBGene00044061" ] }, "reaction_10554302": { "compartment": "compartment_7660", "id": "reaction_10554302", "reactome": "R-CEL-5653838", "name": "POLD,POLE binds deISGylated PCNA after TLS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10554298", "species_10508801" ], "products": [ "species_10554300" ], "modifiers": [], "additional_components": [ "Q95Y97", "WBGene00019767", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "O02115", "WBGene00003955", "P90829", "WBGene00008645", "Q19366", "WBGene00008722", "Q21730", "WBGene00011016", "P90829", "WBGene00008645", "Q19366", "WBGene00008722", "Q21730", "WBGene00011016", "Q95Y97", "WBGene00019767", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "O02115", "WBGene00003955" ] }, "reaction_10551331": { "compartment": "compartment_263163", "id": "reaction_10551331", "reactome": "R-CEL-5333658", "name": "CLAT:AP1:CLVS bind PI(3,5)P2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10551327", "species_5334668" ], "products": [ "species_10551329" ], "modifiers": [], "additional_components": [ "P35602", "WBGene00006829", "O01755", "WBGene00000150", "O16369", "WBGene00000159", "Q9N4F3", "WBGene00000160", "Q8WQB3", "WBGene00000158", "P34574", "WBGene00011867", "species_5334668", "P35602", "WBGene00006829", "O01755", "WBGene00000150", "O16369", "WBGene00000159", "Q9N4F3", "WBGene00000160", "Q8WQB3", "WBGene00000158", "P34574", "WBGene00011867" ] }, "reaction_10524037": { "compartment": "compartment_70101", "id": "reaction_10524037", "reactome": "R-CEL-432706", "name": "trans-Golgi Network Lysosome Vesicle Destined Membrane Coat Assembly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10524031", "species_10522248", "species_10512231", "species_10522246" ], "products": [ "species_10517983", "species_29372", "species_10524035" ], "modifiers": [], "additional_components": [ "Q8WQB3", "WBGene00000158", "O01755", "WBGene00000150", "P35602", "WBGene00006829", "O16369", "WBGene00000159", "Q9N4F3", "WBGene00000160", "P51485", "WBGene00000195", "G5EFK4", "WBGene00000183", "species_29438", "WBGene00001130", "WBGene00006791", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "species_29420", "G5EFK4", "WBGene00000183", "Q8WQB3", "WBGene00000158", "O01755", "WBGene00000150", "P35602", "WBGene00006829", "O16369", "WBGene00000159", "Q9N4F3", "WBGene00000160", "P51485", "WBGene00000195", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "B1V8A0", "WBGene00006791", "P39055", "WBGene00001130" ] }, "reaction_10524040": { "compartment": "compartment_70101", "id": "reaction_10524040", "reactome": "R-CEL-432707", "name": "trans-Golgi Network Lysosomal Vesicle Scission", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10524035" ], "products": [ "species_29372", "species_29420", "species_10522248", "species_10512231", "species_10524001" ], "modifiers": [ [ "species_10524035", "catalyst" ] ], "additional_components": [ "Q8WQB3", "WBGene00000158", "O01755", "WBGene00000150", "P35602", "WBGene00006829", "O16369", "WBGene00000159", "Q9N4F3", "WBGene00000160", "P51485", "WBGene00000195", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "B1V8A0", "WBGene00006791", "P39055", "WBGene00001130", "WBGene00001130", "WBGene00006791", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "O01755", "WBGene00000150", "P35602", "WBGene00006829", "O16369", "WBGene00000159", "Q8WQB3", "WBGene00000158", "Q9N4F3", "WBGene00000160", "P51485", "WBGene00000195", "Q8WQB3", "WBGene00000158", "O01755", "WBGene00000150", "P35602", "WBGene00006829", "O16369", "WBGene00000159", "Q9N4F3", "WBGene00000160", "P51485", "WBGene00000195", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "B1V8A0", "WBGene00006791", "P39055", "WBGene00001130" ] }, "reaction_10554828": { "compartment": "compartment_20699", "id": "reaction_10554828", "reactome": "R-CEL-5671702", "name": "AP1G2 binds HGS and CHMP2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10554824", "species_10529030", "species_10512214" ], "products": [ "species_10554826" ], "modifiers": [], "additional_components": [ "WBGene00000158", "WBGene00012903", "WBGene00004101", "Q9U2F6", "WBGene00012903", "Q17796", "WBGene00004101", "Q8WQB3", "WBGene00000158" ] }, "reaction_10518097": { "compartment": "compartment_13231", "id": "reaction_10518097", "reactome": "R-CEL-351947", "name": "Nuclear translocation of catalytic domain of Mst3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10518081" ], "products": [ "species_10518095" ], "modifiers": [], "additional_components": [ "WBGene00001526", "WBGene00001526" ] }, "reaction_10518085": { "compartment": "compartment_70101", "id": "reaction_10518085", "reactome": "R-CEL-351901", "name": "Caspase-mediated cleavage of MST3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10518079" ], "products": [ "species_10518083", "species_10518081" ], "modifiers": [ [ "species_10509422", "catalyst" ] ], "additional_components": [ "WBGene00001526", "WBGene00001526", "WBGene00001526", "P42573", "WBGene00000417" ] }, "reaction_10515329": { "compartment": "compartment_70101", "id": "reaction_10515329", "reactome": "R-CEL-202917", "name": "Caspase-mediated cleavage of Desmoglein 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10515323" ], "products": [ "species_10515327", "species_10515325" ], "modifiers": [ [ "species_10509422", "catalyst" ] ], "additional_components": [ "WBGene00000396", "WBGene00000396", "WBGene00000396", "P42573", "WBGene00000417" ] }, "reaction_10514849": { "compartment": "compartment_876", "id": "reaction_10514849", "reactome": "R-CEL-201595", "name": "Caspase-mediated cleavage of plakophilin-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10514844" ], "products": [ "species_10514846" ], "modifiers": [ [ "species_10509422", "catalyst" ] ], "additional_components": [ "WBGene00002175", "WBGene00002175", "P42573", "WBGene00000417" ] }, "reaction_10518066": { "compartment": "compartment_876", "id": "reaction_10518066", "reactome": "R-CEL-351877", "name": "Caspase-mediated cleavage of Desmoglein 2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10518062" ], "products": [ "species_10518064" ], "modifiers": [ [ "species_10509422", "catalyst" ] ], "additional_components": [ "WBGene00000396", "WBGene00000396", "P42573", "WBGene00000417" ] }, "reaction_10518052": { "compartment": "compartment_876", "id": "reaction_10518052", "reactome": "R-CEL-351871", "name": "Caspase-mediated cleavage of Z0-2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10518048" ], "products": [ "species_10518050" ], "modifiers": [ [ "species_10509422", "catalyst" ] ], "additional_components": [ "WBGene00013683", "WBGene00013683", "P42573", "WBGene00000417" ] }, "reaction_10514901": { "compartment": "compartment_70101", "id": "reaction_10514901", "reactome": "R-CEL-201631", "name": "Caspase-mediated cleavage of Desmoglein 3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10514895" ], "products": [ "species_10514899", "species_10514897" ], "modifiers": [ [ "species_10509422", "catalyst" ] ], "additional_components": [ "WBGene00000396", "WBGene00000396", "WBGene00000396", "P42573", "WBGene00000417" ] }, "reaction_10515367": { "compartment": "compartment_70101", "id": "reaction_10515367", "reactome": "R-CEL-202969", "name": "Caspase mediated cleavage of beta-catenin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10515361" ], "products": [ "species_10515365", "species_10515363" ], "modifiers": [ [ "species_10509422", "catalyst" ] ], "additional_components": [ "WBGene00001979", "WBGene00001979", "P42573", "WBGene00000417" ] }, "reaction_10514919": { "compartment": "compartment_70101", "id": "reaction_10514919", "reactome": "R-CEL-201636", "name": "Caspase-mediated cleavage of Desmoplakin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10514915" ], "products": [ "species_10514917" ], "modifiers": [ [ "species_10509422", "catalyst" ] ], "additional_components": [ "WBGene00006876", "WBGene00006876", "P42573", "WBGene00000417" ] }, "reaction_10518089": { "compartment": "compartment_876", "id": "reaction_10518089", "reactome": "R-CEL-351913", "name": "Caspase-mediated cleavage of TJP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10518087" ], "products": [ "species_10518050" ], "modifiers": [ [ "species_10509422", "catalyst" ] ], "additional_components": [ "WBGene00013683", "WBGene00013683", "P42573", "WBGene00000417" ] }, "reaction_10518060": { "compartment": "compartment_70101", "id": "reaction_10518060", "reactome": "R-CEL-351876", "name": "Caspase-mediated cleavage of occludin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10518054" ], "products": [ "species_10518058", "species_10518056" ], "modifiers": [ [ "species_10509422", "catalyst" ] ], "additional_components": [ "WBGene00021281", "WBGene00021281", "WBGene00021281", "P42573", "WBGene00000417" ] }, "reaction_10514936": { "compartment": "compartment_70101", "id": "reaction_10514936", "reactome": "R-CEL-201640", "name": "Caspase-mediated cleavage of farnesyltransferase/geranyl- geranyltransferase subunit alpha ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10514930" ], "products": [ "species_10514934", "species_10514932" ], "modifiers": [ [ "species_10509422", "catalyst" ] ], "additional_components": [ "WBGene00019823", "WBGene00019823", "WBGene00019823", "P42573", "WBGene00000417" ] }, "reaction_10517976": { "compartment": "compartment_70101", "id": "reaction_10517976", "reactome": "R-CEL-350651", "name": "Caspase-mediated cleavage of MASK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10517970" ], "products": [ "species_10517974", "species_10517972" ], "modifiers": [ [ "species_10509422", "catalyst" ] ], "additional_components": [ "WBGene00001526", "WBGene00001526", "WBGene00001526", "P42573", "WBGene00000417" ] }, "reaction_10515337": { "compartment": "compartment_70101", "id": "reaction_10515337", "reactome": "R-CEL-202947", "name": "Caspase mediated cleavage of APC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10515331" ], "products": [ "species_10515335", "species_10515333" ], "modifiers": [ [ "species_10509422", "catalyst" ] ], "additional_components": [ "WBGene00000156", "WBGene00000156", "WBGene00000156", "P42573", "WBGene00000417" ] }, "reaction_10517161": { "compartment": "compartment_70101", "id": "reaction_10517161", "reactome": "R-CEL-212552", "name": "Caspase 3-mediated cleavage of PKC delta", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509049" ], "products": [ "species_10517159", "species_10517157" ], "modifiers": [ [ "species_10509422", "catalyst" ] ], "additional_components": [ "WBGene00006599", "WBGene00006599", "WBGene00006599", "P42573", "WBGene00000417" ] }, "reaction_10514857": { "compartment": "compartment_70101", "id": "reaction_10514857", "reactome": "R-CEL-201603", "name": "Caspase-mediated cleavage of PKC theta", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10514851" ], "products": [ "species_10514855", "species_10514853" ], "modifiers": [ [ "species_10509422", "catalyst" ] ], "additional_components": [ "WBGene00006599", "WBGene00006599", "WBGene00006599", "P42573", "WBGene00000417" ] }, "reaction_10514890": { "compartment": "compartment_70101", "id": "reaction_10514890", "reactome": "R-CEL-201630", "name": "Caspase-mediated cleavage of Acinus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10514884" ], "products": [ "species_10514888", "species_10514886" ], "modifiers": [ [ "species_10509422", "catalyst" ] ], "additional_components": [ "WBGene00016601", "WBGene00016601", "WBGene00016601", "P42573", "WBGene00000417" ] }, "reaction_10514879": { "compartment": "compartment_70101", "id": "reaction_10514879", "reactome": "R-CEL-201611", "name": "Caspase-mediated cleavage of Rock-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10514873" ], "products": [ "species_10514877", "species_10514875" ], "modifiers": [ [ "species_10509422", "catalyst" ] ], "additional_components": [ "WBGene00002694", "WBGene00002694", "WBGene00002694", "P42573", "WBGene00000417" ] }, "reaction_10518106": { "compartment": "compartment_70101", "id": "reaction_10518106", "reactome": "R-CEL-351948", "name": "Mitochondrial recruitment of Drp1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10518102" ], "products": [ "species_10518104" ], "modifiers": [ [ "species_10518073", "catalyst" ] ], "additional_components": [ "WBGene00001093", "WBGene00001093", "WBGene00021883" ] }, "reaction_10512852": { "compartment": "compartment_876", "id": "reaction_10512852", "reactome": "R-CEL-189242", "name": "SLC2A2 tetramer transports Fru, Gal, Glc from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189246" ], "products": [ "species_189219" ], "modifiers": [ [ "species_10512849", "catalyst" ] ], "additional_components": [ "species_70113", "species_188995", "species_29532", "species_188995", "species_70113", "species_29532", "Q23626", "WBGene00022014", "Q95QY6", "WBGene00022014", "Q9GPA2", "WBGene00022014", "Q9N309", "WBGene00022014", "Q9U2K5", "WBGene00022014", "Q9XU83", "WBGene00022014", "Q9XVL3", "WBGene00022014", "G5EC93", "WBGene00022014", "O16547", "WBGene00022014", "O44616", "WBGene00022014", "O44827", "WBGene00019207", "O45920", "WBGene00022014", "Q11114", "WBGene00022014", "Q19376", "WBGene00022014", "Q20734", "WBGene00022014", "Q23535", "WBGene00006865" ] }, "reaction_10512813": { "compartment": "compartment_876", "id": "reaction_10512813", "reactome": "R-CEL-189222", "name": "SLC2A5 transports fructose from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189049" ], "products": [ "species_29532" ], "modifiers": [ [ "species_10512810", "catalyst" ] ], "additional_components": [ "Q20734", "WBGene00022014", "O16547", "WBGene00022014", "Q9XU83", "WBGene00022014", "Q23535", "WBGene00006865", "O44616", "WBGene00022014", "Q9XVL3", "WBGene00022014", "Q23626", "WBGene00022014", "O44827", "WBGene00019207", "Q95QY6", "WBGene00022014", "O45920", "WBGene00022014", "Q9GPA2", "WBGene00022014", "Q11114", "WBGene00022014", "Q9N309", "WBGene00022014", "Q19376", "WBGene00022014", "G5EC93", "WBGene00022014", "Q9U2K5", "WBGene00022014" ] }, "reaction_10554240": { "compartment": "compartment_7660", "id": "reaction_10554240", "reactome": "R-CEL-5652009", "name": "RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502318", "species_10554233" ], "products": [ "species_10554237", "species_10554231", "species_10508801" ], "modifiers": [ [ "species_10554233", "catalyst" ] ], "additional_components": [ "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "Q95Y97", "WBGene00019767", "P90829", "WBGene00008645", "Q19366", "WBGene00008722", "Q21730", "WBGene00011016", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "O02115", "WBGene00003955", "Q21554", "WBGene00010890", "Q23457", "WBGene00004320", "Q22059", "WBGene00011318", "Q17392", "WBGene00000839", "Q95Y97", "WBGene00019767", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "O02115", "WBGene00003955", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "Q21554", "WBGene00010890", "Q23457", "WBGene00004320", "Q22059", "WBGene00011318", "Q17392", "WBGene00000839", "P90829", "WBGene00008645", "Q19366", "WBGene00008722", "Q21730", "WBGene00011016", "Q95Y97", "WBGene00019767", "P90829", "WBGene00008645", "Q19366", "WBGene00008722", "Q21730", "WBGene00011016", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "O02115", "WBGene00003955", "Q21554", "WBGene00010890", "Q23457", "WBGene00004320", "Q22059", "WBGene00011318", "Q17392", "WBGene00000839" ] }, "reaction_10554235": { "compartment": "compartment_7660", "id": "reaction_10554235", "reactome": "R-CEL-5652005", "name": "RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10554231", "species_10554212" ], "products": [ "species_10554233" ], "modifiers": [], "additional_components": [ "Q21554", "WBGene00010890", "Q23457", "WBGene00004320", "Q22059", "WBGene00011318", "Q17392", "WBGene00000839", "Q95Y97", "WBGene00019767", "P90829", "WBGene00008645", "Q19366", "WBGene00008722", "Q21730", "WBGene00011016", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "O02115", "WBGene00003955", "Q95Y97", "WBGene00019767", "P90829", "WBGene00008645", "Q19366", "WBGene00008722", "Q21730", "WBGene00011016", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "O02115", "WBGene00003955", "Q21554", "WBGene00010890", "Q23457", "WBGene00004320", "Q22059", "WBGene00011318", "Q17392", "WBGene00000839" ] }, "reaction_10554419": { "compartment": "compartment_7660", "id": "reaction_10554419", "reactome": "R-CEL-5654989", "name": "SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10554410" ], "products": [ "species_113582", "species_10508757", "species_10554416" ], "modifiers": [ [ "species_10554410", "catalyst" ] ], "additional_components": [ "Q22557", "WBGene00011834", "Q95Y97", "WBGene00019767", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "O02115", "WBGene00003955", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "G5EFY1", "WBGene00018721", "Q95QZ9", "WBGene00019121", "Q19584", "WBGene00006733", "P54812", "WBGene00008053", "WBGene00018721", "Q95Y97", "WBGene00019767", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "O02115", "WBGene00003955", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "Q22557", "WBGene00011834", "Q95QZ9", "WBGene00019121", "Q19584", "WBGene00006733", "P54812", "WBGene00008053", "Q22557", "WBGene00011834", "Q95Y97", "WBGene00019767", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "O02115", "WBGene00003955", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "G5EFY1", "WBGene00018721", "Q95QZ9", "WBGene00019121", "Q19584", "WBGene00006733", "P54812", "WBGene00008053" ] }, "reaction_10508774": { "compartment": "compartment_7660", "id": "reaction_10508774", "reactome": "R-CEL-110317", "name": "Insertion of correct bases opposite the lesion by POLH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508763", "species_29604" ], "products": [ "species_113541", "species_10508771" ], "modifiers": [ [ "species_10508763", "catalyst" ] ], "additional_components": [ "G5EFY1", "WBGene00018721", "Q95Y97", "WBGene00019767", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "O02115", "WBGene00003955", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "Q95Y97", "WBGene00019767", "O02115", "WBGene00003955", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "G5EFY1", "WBGene00018721", "G5EFY1", "WBGene00018721", "Q95Y97", "WBGene00019767", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "O02115", "WBGene00003955", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725" ] }, "reaction_10508765": { "compartment": "compartment_7660", "id": "reaction_10508765", "reactome": "R-CEL-110316", "name": "POLH binds monoUb:K164-PCNA at damaged TT-CPD-DNA template", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508761", "species_10508757" ], "products": [ "species_10508763" ], "modifiers": [], "additional_components": [ "Q95Y97", "WBGene00019767", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "O02115", "WBGene00003955", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "WBGene00018721", "G5EFY1", "WBGene00018721", "Q95Y97", "WBGene00019767", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "O02115", "WBGene00003955", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725" ] }, "reaction_10508781": { "compartment": "compartment_7660", "id": "reaction_10508781", "reactome": "R-CEL-110319", "name": "Elongation by POLH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30555", "species_10508771" ], "products": [ "species_10508778", "species_113541" ], "modifiers": [ [ "species_10508771", "catalyst" ] ], "additional_components": [ "Q95Y97", "WBGene00019767", "O02115", "WBGene00003955", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "G5EFY1", "WBGene00018721", "Q95Y97", "WBGene00019767", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "O02115", "WBGene00003955", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "G5EFY1", "WBGene00018721", "Q95Y97", "WBGene00019767", "O02115", "WBGene00003955", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "G5EFY1", "WBGene00018721" ] }, "reaction_10554412": { "compartment": "compartment_7660", "id": "reaction_10554412", "reactome": "R-CEL-5654985", "name": "SPRTN recruits VCP to monoUb:K164-PCNA associated with POLH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10554408", "species_10554392" ], "products": [ "species_10554410" ], "modifiers": [], "additional_components": [ "Q95QZ9", "WBGene00019121", "Q19584", "WBGene00006733", "P54812", "WBGene00008053", "Q22557", "WBGene00011834", "Q95Y97", "WBGene00019767", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "O02115", "WBGene00003955", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "G5EFY1", "WBGene00018721", "Q22557", "WBGene00011834", "Q95Y97", "WBGene00019767", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "O02115", "WBGene00003955", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "G5EFY1", "WBGene00018721", "Q95QZ9", "WBGene00019121", "Q19584", "WBGene00006733", "P54812", "WBGene00008053" ] }, "reaction_10554414": { "compartment": "compartment_7660", "id": "reaction_10554414", "reactome": "R-CEL-5654986", "name": "SPRTN binds monoUb:K164-PCNA associated with POLH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508778", "species_10554390" ], "products": [ "species_10554392" ], "modifiers": [], "additional_components": [ "Q95Y97", "WBGene00019767", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "O02115", "WBGene00003955", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "G5EFY1", "WBGene00018721", "WBGene00011834", "Q22557", "WBGene00011834", "Q95Y97", "WBGene00019767", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "O02115", "WBGene00003955", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "G5EFY1", "WBGene00018721" ] }, "reaction_10556021": { "compartment": "compartment_7660", "id": "reaction_10556021", "reactome": "R-CEL-5687664", "name": "FEN1 cleaves displaced ssDNA flaps during MMEJ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10556014" ], "products": [ "species_68454", "species_10502724", "species_10556018" ], "modifiers": [ [ "species_10556014", "catalyst" ] ], "additional_components": [ "Q9N3T2", "WBGene00000794", "Q18606", "WBGene00008082", "Q23255", "WBGene00003405", "O44199", "WBGene00004296", "WBGene00000794", "Q23255", "WBGene00003405", "O44199", "WBGene00004296", "Q18606", "WBGene00008082", "Q9N3T2", "WBGene00000794", "Q18606", "WBGene00008082", "Q23255", "WBGene00003405", "O44199", "WBGene00004296" ] }, "reaction_10556008": { "compartment": "compartment_7660", "id": "reaction_10556008", "reactome": "R-CEL-5687464", "name": "MRN and RBBP8 resect DNA DSBs in MMEJ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10556001" ], "products": [ "species_30555", "species_10556005" ], "modifiers": [ [ "species_10556001", "catalyst" ] ], "additional_components": [ "Q18606", "WBGene00008082", "Q23255", "WBGene00003405", "O44199", "WBGene00004296", "Q23255", "WBGene00003405", "O44199", "WBGene00004296", "Q18606", "WBGene00008082", "Q18606", "WBGene00008082", "Q23255", "WBGene00003405", "O44199", "WBGene00004296" ] }, "reaction_10519896": { "compartment": "compartment_5460", "id": "reaction_10519896", "reactome": "R-CEL-380608", "name": "5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113526", "species_380598" ], "products": [ "species_113529", "species_380593", "species_29362" ], "modifiers": [ [ "species_10504264", "catalyst" ] ], "additional_components": [ "Q20780", "WBGene00000107" ] }, "reaction_10524588": { "compartment": "compartment_876", "id": "reaction_10524588", "reactome": "R-CEL-444008", "name": "SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_188972", "species_114523", "species_74113" ], "products": [ "species_209914", "species_83910", "species_352022" ], "modifiers": [ [ "species_10524585", "catalyst" ] ], "additional_components": [ "WBGene00003387" ] }, "reaction_10517995": { "compartment": "compartment_70101", "id": "reaction_10517995", "reactome": "R-CEL-350769", "name": "trans-Golgi Network Coat Activation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10517983", "species_29438" ], "products": [ "species_29420", "species_10517987" ], "modifiers": [ [ "species_10517992", "catalyst" ] ], "additional_components": [ "species_29420", "G5EFK4", "WBGene00000183", "G5EFK4", "WBGene00000183", "species_29438", "WBGene00007703" ] }, "reaction_10522258": { "compartment": "compartment_20699", "id": "reaction_10522258", "reactome": "R-CEL-421831", "name": "trans-Golgi Network Coat Assembly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10522248", "species_10512231", "species_10522246", "species_10522240" ], "products": [ "species_10517983", "species_29372", "species_10522256" ], "modifiers": [], "additional_components": [ "WBGene00001130", "WBGene00006791", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "Q8WQB3", "WBGene00000158", "O01755", "WBGene00000150", "P35602", "WBGene00006829", "O16369", "WBGene00000159", "Q9N4F3", "WBGene00000160", "P51485", "WBGene00000195", "G5EFK4", "WBGene00000183", "species_29438", "species_29420", "G5EFK4", "WBGene00000183", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "B1V8A0", "WBGene00006791", "Q8WQB3", "WBGene00000158", "O01755", "WBGene00000150", "P35602", "WBGene00006829", "O16369", "WBGene00000159", "Q9N4F3", "WBGene00000160", "P51485", "WBGene00000195", "P39055", "WBGene00001130" ] }, "reaction_10522389": { "compartment": "compartment_70101", "id": "reaction_10522389", "reactome": "R-CEL-421835", "name": "trans-Golgi Network Vesicle Scission", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10522256" ], "products": [ "species_29372", "species_29420", "species_10522248", "species_10512231", "species_10522386" ], "modifiers": [ [ "species_10522256", "catalyst" ] ], "additional_components": [ "P34574", "WBGene00011867", "P90961", "WBGene00020246", "B1V8A0", "WBGene00006791", "Q8WQB3", "WBGene00000158", "O01755", "WBGene00000150", "P35602", "WBGene00006829", "O16369", "WBGene00000159", "Q9N4F3", "WBGene00000160", "P51485", "WBGene00000195", "P39055", "WBGene00001130", "WBGene00001130", "WBGene00006791", "P51485", "WBGene00000195", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "P35602", "WBGene00006829", "O01755", "WBGene00000150", "O16369", "WBGene00000159", "Q8WQB3", "WBGene00000158", "Q9N4F3", "WBGene00000160", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "B1V8A0", "WBGene00006791", "Q8WQB3", "WBGene00000158", "O01755", "WBGene00000150", "P35602", "WBGene00006829", "O16369", "WBGene00000159", "Q9N4F3", "WBGene00000160", "P51485", "WBGene00000195", "P39055", "WBGene00001130" ] }, "reaction_10566464": { "compartment": "compartment_876", "id": "reaction_10566464", "reactome": "R-CEL-8867756", "name": "CLASP proteins and cargo are recruited to the nascent clathrin-coated pit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10566399", "species_10565777" ], "products": [ "species_10566401" ], "modifiers": [], "additional_components": [ "Q95XH1", "WBGene00022077", "G5EBK2", "WBGene00014084", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q19767", "WBGene00004898", "Q94057", "WBGene00044062", "Q9XZI6", "WBGene00006751", "Q9N532", "WBGene00003238", "G5EDV1", "WBGene00003006", "P34889", "WBGene00000858", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "Q9U7D5", "WBGene00001519", "P51485", "WBGene00000195", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "P90761", "WBGene00006777", "Q9BIF4", "WBGene00001224", "Q18453", "WBGene00004682", "Q9BI71", "WBGene00001329", "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "B1V8A0", "WBGene00006791", "P29355", "WBGene00004774", "Q17796", "WBGene00004101", "O01498", "WBGene00004109", "Q21496", "WBGene00020010", "Q21948", "WBGene00020010", "A0A486WXX8", "WBGene00000894", "Q95QV2", "WBGene00000477", "Q19625", "WBGene00003412", "P34711", "WBGene00006756", "Q9XTT3", "WBGene00013039", "G5ECQ3", "WBGene00004762", "Q20483", "WBGene00018516", "Q9BIF4", "WBGene00001224", "species_179856", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "Q9TXS0", "WBGene00018974", "Q9N489", "WBGene00022453", "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "Q19123", "WBGene00000157", "P35603", "WBGene00001082", "A0A0K3AS36", "Y116A8C.36d", "G5ECQ3", "WBGene00004762", "Q20483", "WBGene00018516", "Q9BIF4", "WBGene00001224", "species_179856", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "Q9TXS0", "WBGene00018974", "Q9N489", "WBGene00022453", "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "Q19123", "WBGene00000157", "P35603", "WBGene00001082", "A0A0K3AS36", "Y116A8C.36d", "Q95XH1", "WBGene00022077", "G5EBK2", "WBGene00014084", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q19767", "WBGene00004898", "Q94057", "WBGene00044062", "Q9XZI6", "WBGene00006751", "Q9N532", "WBGene00003238", "G5EDV1", "WBGene00003006", "P34889", "WBGene00000858", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "Q9U7D5", "WBGene00001519", "P51485", "WBGene00000195", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "P90761", "WBGene00006777", "Q18453", "WBGene00004682", "Q9BI71", "WBGene00001329", "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "B1V8A0", "WBGene00006791", "P29355", "WBGene00004774", "Q17796", "WBGene00004101", "O01498", "WBGene00004109", "Q21496", "WBGene00020010", "Q21948", "WBGene00020010", "A0A486WXX8", "WBGene00000894", "Q95QV2", "WBGene00000477", "Q19625", "WBGene00003412", "P34711", "WBGene00006756", "Q9XTT3", "WBGene00013039" ] }, "reaction_10567111": { "compartment": "compartment_24339", "id": "reaction_10567111", "reactome": "R-CEL-8871193", "name": "Dissociation of AAK1 and dephosphorylation of AP-2 mu2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10567109" ], "products": [ "species_10566724", "species_10565728" ], "modifiers": [], "additional_components": [ "P91857", "WBGene00004268", "species_29420", "Q9GYH7", "WBGene00004377", "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q9XTT3", "WBGene00013039", "Q19625", "WBGene00003412", "Q95QV2", "WBGene00000477", "P34711", "WBGene00006756", "Q21496", "WBGene00020010", "Q21948", "WBGene00020010", "A0A486WXX8", "WBGene00000894", "O02495", "WBGene00004897", "G5EBK2", "WBGene00014084", "P34351", "WBGene00004899", "Q19767", "WBGene00004898", "Q94057", "WBGene00044062", "Q95XH1", "WBGene00022077", "Q9XZI6", "WBGene00006751", "Q9BIF4", "WBGene00001224", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "B1V8A0", "WBGene00006791", "Q18453", "WBGene00004682", "Q9BI71", "WBGene00001329", "P29355", "WBGene00004774", "Q17796", "WBGene00004101", "O01498", "WBGene00004109", "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "P34889", "WBGene00000858", "G5EDV1", "WBGene00003006", "Q9N532", "WBGene00003238", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "Q9U7D5", "WBGene00001519", "P51485", "WBGene00000195", "P90761", "WBGene00006777", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "Q02328", "WBGene00022717", "G5ECQ3", "WBGene00004762", "Q20483", "WBGene00018516", "P0DM42", "WBGene00000065", "P10984", "WBGene00000064", "P10986", "WBGene00000066", "P0DM41", "WBGene00000063", "species_29358", "Q19253", "WBGene00017298", "P58798", "WBGene00000204", "A0A3P6PCS5", "WBGene00000201", "Q9N4I0", "WBGene00000199", "Q8WTM6", "WBGene00021170", "P53489", "WBGene00000200", "Q9XWV3", "WBGene00000203", "O61861", "WBGene00000205", "P91167", "WBGene00016729", "species_1806234", "Q21004", "WBGene00010272", "Q9XUS7", "WBGene00010663", "Q9TXS0", "WBGene00018974", "A0A486WXP9", "WBGene00001043", "Q6AHQ8", "WBGene00018467", "Q9N489", "WBGene00022453", "Q8I4E2", "WBGene00003086", "A0A0K3AS36", "Y116A8C.36d", "P39055", "WBGene00001130", "O17590", "WBGene00007620", "G5ECL2", "WBGene00006763", "P91857", "WBGene00004268", "species_29438", "Q9GYH7", "WBGene00004377", "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q9XTT3", "WBGene00013039", "Q19625", "WBGene00003412", "Q95QV2", "WBGene00000477", "P34711", "WBGene00006756", "Q21496", "WBGene00020010", "Q21948", "WBGene00020010", "A0A486WXX8", "WBGene00000894", "O02495", "WBGene00004897", "G5EBK2", "WBGene00014084", "P34351", "WBGene00004899", "Q19767", "WBGene00004898", "Q94057", "WBGene00044062", "Q95XH1", "WBGene00022077", "Q9XZI6", "WBGene00006751", "Q9BIF4", "WBGene00001224", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "B1V8A0", "WBGene00006791", "Q18453", "WBGene00004682", "Q9BI71", "WBGene00001329", "P29355", "WBGene00004774", "Q17796", "WBGene00004101", "O01498", "WBGene00004109", "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "P34889", "WBGene00000858", "G5EDV1", "WBGene00003006", "Q9N532", "WBGene00003238", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "Q9U7D5", "WBGene00001519", "P51485", "WBGene00000195", "P90761", "WBGene00006777", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "Q02328", "WBGene00022717", "P0DM42", "WBGene00000065", "P10984", "WBGene00000064", "P10986", "WBGene00000066", "P0DM41", "WBGene00000063", "species_29358", "Q19253", "WBGene00017298", "P58798", "WBGene00000204", "A0A3P6PCS5", "WBGene00000201", "Q9N4I0", "WBGene00000199", "Q8WTM6", "WBGene00021170", "P53489", "WBGene00000200", "Q9XWV3", "WBGene00000203", "O61861", "WBGene00000205", "P91167", "WBGene00016729", "species_1806234", "Q21004", "WBGene00010272", "Q9XUS7", "WBGene00010663", "Q9TXS0", "WBGene00018974", "A0A486WXP9", "WBGene00001043", "Q6AHQ8", "WBGene00018467", "Q9N489", "WBGene00022453", "Q8I4E2", "WBGene00003086", "A0A0K3AS36", "Y116A8C.36d", "P39055", "WBGene00001130", "species_29420", "O17590", "WBGene00007620", "G5ECL2", "WBGene00006763", "G5ECQ3", "WBGene00004762", "Q20483", "WBGene00018516" ] }, "reaction_10565769": { "compartment": "compartment_876", "id": "reaction_10565769", "reactome": "R-CEL-8856808", "name": "Recruitment of AP-2 complex and clathrin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10548814", "species_10565757", "species_10565755", "species_10522246", "species_10565728" ], "products": [ "species_10565761" ], "modifiers": [ [ "species_10565767", "catalyst" ] ], "additional_components": [ "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "WBGene00022453", "Q9BIF4", "WBGene00001224", "species_179856", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q9TXS0", "WBGene00018974", "A0A0K3AS36", "Y116A8C.36d", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "G5ECQ3", "WBGene00004762", "Q20483", "WBGene00018516", "G5ECQ3", "WBGene00004762", "Q20483", "WBGene00018516", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "Q9BIF4", "WBGene00001224", "species_179856", "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q9TXS0", "WBGene00018974", "A0A0K3AS36", "Y116A8C.36d", "Q9N489", "WBGene00022453", "Q9U2S4", "WBGene00000184", "species_29438", "P90904", "WBGene00010500" ] }, "reaction_10567113": { "compartment": "compartment_24339", "id": "reaction_10567113", "reactome": "R-CEL-8871194", "name": "RAB5 and GAPVD1 bind AP-2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10566661", "species_10567107" ], "products": [ "species_10567109" ], "modifiers": [], "additional_components": [ "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q9XTT3", "WBGene00013039", "Q19625", "WBGene00003412", "Q95QV2", "WBGene00000477", "P34711", "WBGene00006756", "Q21496", "WBGene00020010", "Q21948", "WBGene00020010", "A0A486WXX8", "WBGene00000894", "O02495", "WBGene00004897", "G5EBK2", "WBGene00014084", "P34351", "WBGene00004899", "Q19767", "WBGene00004898", "Q94057", "WBGene00044062", "Q95XH1", "WBGene00022077", "Q9XZI6", "WBGene00006751", "Q9BIF4", "WBGene00001224", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "B1V8A0", "WBGene00006791", "Q18453", "WBGene00004682", "Q9BI71", "WBGene00001329", "P29355", "WBGene00004774", "Q17796", "WBGene00004101", "O01498", "WBGene00004109", "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "P34889", "WBGene00000858", "G5EDV1", "WBGene00003006", "Q9N532", "WBGene00003238", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "Q9U7D5", "WBGene00001519", "P51485", "WBGene00000195", "P90761", "WBGene00006777", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "Q02328", "WBGene00022717", "G5ECQ3", "WBGene00004762", "Q20483", "WBGene00018516", "P0DM42", "WBGene00000065", "P10984", "WBGene00000064", "P10986", "WBGene00000066", "P0DM41", "WBGene00000063", "species_29358", "Q19253", "WBGene00017298", "P58798", "WBGene00000204", "A0A3P6PCS5", "WBGene00000201", "Q9N4I0", "WBGene00000199", "Q8WTM6", "WBGene00021170", "P53489", "WBGene00000200", "Q9XWV3", "WBGene00000203", "O61861", "WBGene00000205", "P91167", "WBGene00016729", "species_1806234", "Q21004", "WBGene00010272", "Q9XUS7", "WBGene00010663", "Q9TXS0", "WBGene00018974", "A0A486WXP9", "WBGene00001043", "Q6AHQ8", "WBGene00018467", "Q9N489", "WBGene00022453", "Q8I4E2", "WBGene00003086", "A0A0K3AS36", "Y116A8C.36d", "P39055", "WBGene00001130", "species_29420", "O17590", "WBGene00007620", "G5ECL2", "WBGene00006763", "P91857", "WBGene00004268", "species_29420", "Q9GYH7", "WBGene00004377", "P91857", "WBGene00004268", "species_29420", "Q9GYH7", "WBGene00004377", "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q9XTT3", "WBGene00013039", "Q19625", "WBGene00003412", "Q95QV2", "WBGene00000477", "P34711", "WBGene00006756", "Q21496", "WBGene00020010", "Q21948", "WBGene00020010", "A0A486WXX8", "WBGene00000894", "O02495", "WBGene00004897", "G5EBK2", "WBGene00014084", "P34351", "WBGene00004899", "Q19767", "WBGene00004898", "Q94057", "WBGene00044062", "Q95XH1", "WBGene00022077", "Q9XZI6", "WBGene00006751", "Q9BIF4", "WBGene00001224", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "B1V8A0", "WBGene00006791", "Q18453", "WBGene00004682", "Q9BI71", "WBGene00001329", "P29355", "WBGene00004774", "Q17796", "WBGene00004101", "O01498", "WBGene00004109", "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "P34889", "WBGene00000858", "G5EDV1", "WBGene00003006", "Q9N532", "WBGene00003238", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "Q9U7D5", "WBGene00001519", "P51485", "WBGene00000195", "P90761", "WBGene00006777", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "Q02328", "WBGene00022717", "G5ECQ3", "WBGene00004762", "Q20483", "WBGene00018516", "P0DM42", "WBGene00000065", "P10984", "WBGene00000064", "P10986", "WBGene00000066", "P0DM41", "WBGene00000063", "species_29358", "Q19253", "WBGene00017298", "P58798", "WBGene00000204", "A0A3P6PCS5", "WBGene00000201", "Q9N4I0", "WBGene00000199", "Q8WTM6", "WBGene00021170", "P53489", "WBGene00000200", "Q9XWV3", "WBGene00000203", "O61861", "WBGene00000205", "P91167", "WBGene00016729", "species_1806234", "Q21004", "WBGene00010272", "Q9XUS7", "WBGene00010663", "Q9TXS0", "WBGene00018974", "A0A486WXP9", "WBGene00001043", "Q6AHQ8", "WBGene00018467", "Q9N489", "WBGene00022453", "Q8I4E2", "WBGene00003086", "A0A0K3AS36", "Y116A8C.36d", "P39055", "WBGene00001130", "O17590", "WBGene00007620", "G5ECL2", "WBGene00006763" ] }, "reaction_10567115": { "compartment": "compartment_876", "id": "reaction_10567115", "reactome": "R-CEL-8871196", "name": "Initial binding of AP-2 and clathrin to PI(4,5)P2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10548814", "species_10522246", "species_179856" ], "products": [ "species_10565751" ], "modifiers": [], "additional_components": [ "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "species_179856", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "P35603", "WBGene00001082", "Q19123", "WBGene00000157" ] }, "reaction_10566475": { "compartment": "compartment_876", "id": "reaction_10566475", "reactome": "R-CEL-8868066", "name": "PIP5K1C phosphorylates PI(4)P to PI(4,5)P2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_392417" ], "products": [ "species_29370", "species_179856" ], "modifiers": [ [ "species_10521254", "catalyst" ] ], "additional_components": [ "WBGene00004087" ] }, "reaction_10566666": { "compartment": "compartment_24339", "id": "reaction_10566666", "reactome": "R-CEL-8868658", "name": "HSPA8-mediated ATP hydrolysis promotes vesicle uncoating", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10566659" ], "products": [ "species_29372", "species_10566663", "species_10566661" ], "modifiers": [ [ "species_10566659", "catalyst" ] ], "additional_components": [ "Q02328", "WBGene00022717", "G5ECQ3", "WBGene00004762", "Q20483", "WBGene00018516", "Q19253", "WBGene00017298", "P58798", "WBGene00000204", "A0A3P6PCS5", "WBGene00000201", "Q9N4I0", "WBGene00000199", "species_29358", "Q8WTM6", "WBGene00021170", "P53489", "WBGene00000200", "Q9XWV3", "WBGene00000203", "O61861", "WBGene00000205", "P91167", "WBGene00016729", "Q9XUS7", "WBGene00010663", "B1V8A0", "WBGene00006791", "Q9TXS0", "WBGene00018974", "Q9N489", "WBGene00022453", "A0A0K3AS36", "Y116A8C.36d", "P39055", "WBGene00001130", "species_29420", "O17590", "WBGene00007620", "G5ECL2", "WBGene00006763", "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q9XTT3", 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"A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "Q9U7D5", "WBGene00001519", "P51485", "WBGene00000195", "P90761", "WBGene00006777", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "P0DM42", "WBGene00000065", "P10984", "WBGene00000064", "P10986", "WBGene00000066", "P0DM41", "WBGene00000063", "species_1806234", "Q21004", "WBGene00010272", "P09446", "WBGene00002005", "A0A486WXP9", "WBGene00001043", "Q6AHQ8", "WBGene00018467", "Q8I4E2", "WBGene00003086" ] }, "reaction_10566477": { "compartment": "compartment_876", "id": "reaction_10566477", "reactome": "R-CEL-8868071", "name": "Clathrin recruits PIK3C2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10537176", "species_10566401" ], "products": [ "species_10566403" ], "modifiers": [], "additional_components": [ "WBGene00009552", "G5ECQ3", "WBGene00004762", "Q20483", "WBGene00018516", "Q9BIF4", "WBGene00001224", "species_179856", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "Q9TXS0", "WBGene00018974", "Q9N489", "WBGene00022453", "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "Q19123", "WBGene00000157", "P35603", "WBGene00001082", "A0A0K3AS36", "Y116A8C.36d", "Q95XH1", "WBGene00022077", "G5EBK2", "WBGene00014084", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q19767", "WBGene00004898", "Q94057", "WBGene00044062", "Q9XZI6", "WBGene00006751", "Q9N532", "WBGene00003238", "G5EDV1", "WBGene00003006", "P34889", "WBGene00000858", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "Q9U7D5", "WBGene00001519", "P51485", "WBGene00000195", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "P90761", "WBGene00006777", "Q18453", "WBGene00004682", "Q9BI71", "WBGene00001329", "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "B1V8A0", "WBGene00006791", "P29355", "WBGene00004774", "Q17796", "WBGene00004101", "O01498", "WBGene00004109", "Q21496", "WBGene00020010", "Q21948", "WBGene00020010", "A0A486WXX8", "WBGene00000894", "Q95QV2", "WBGene00000477", "Q19625", "WBGene00003412", "P34711", "WBGene00006756", "Q9XTT3", "WBGene00013039", "G5ECQ3", "WBGene00004762", "Q20483", "WBGene00018516", "Q9BIF4", "WBGene00001224", "species_179856", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "Q9TXS0", "WBGene00018974", "Q9N489", "WBGene00022453", "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "Q19123", "WBGene00000157", "P35603", "WBGene00001082", "A0A0K3AS36", "Y116A8C.36d", "Q95XH1", "WBGene00022077", "G5EBK2", "WBGene00014084", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q19767", "WBGene00004898", "Q94057", "WBGene00044062", "Q9XZI6", "WBGene00006751", "Q9N532", "WBGene00003238", "G5EDV1", "WBGene00003006", "P34889", "WBGene00000858", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "Q9U7D5", "WBGene00001519", "P51485", "WBGene00000195", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "P90761", "WBGene00006777", "Q18453", "WBGene00004682", "Q9BI71", "WBGene00001329", "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "B1V8A0", "WBGene00006791", "P29355", "WBGene00004774", "Q17796", "WBGene00004101", "O01498", "WBGene00004109", "Q21496", "WBGene00020010", "Q21948", "WBGene00020010", "A0A486WXX8", "WBGene00000894", "Q95QV2", "WBGene00000477", "Q19625", "WBGene00003412", "P34711", "WBGene00006756", "Q9XTT3", "WBGene00013039", "G5EDY0", "WBGene00009552" ] }, "reaction_10566508": { "compartment": "compartment_876", "id": "reaction_10566508", "reactome": "R-CEL-8868236", "name": "BAR domain proteins recruit dynamin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10566504", "species_10566502" ], "products": [ "species_10566506" ], "modifiers": [], "additional_components": [ "P39055", "WBGene00001130", "species_29438", "Q02328", "WBGene00022717", "P0DM42", "WBGene00000065", "P10984", "WBGene00000064", "P10986", "WBGene00000066", "P0DM41", "WBGene00000063", "species_29358", "P58798", "WBGene00000204", "A0A3P6PCS5", "WBGene00000201", "Q9N4I0", "WBGene00000199", "Q8WTM6", "WBGene00021170", "P53489", "WBGene00000200", "Q9XWV3", "WBGene00000203", "O61861", "WBGene00000205", "P91167", "WBGene00016729", "Q19253", "WBGene00017298", "Q9XUS7", "WBGene00010663", "B1V8A0", "WBGene00006791", "Q21004", "WBGene00010272", "Q9BIF4", "WBGene00001224", "G5ECQ3", "WBGene00004762", "Q20483", "WBGene00018516", "species_179856", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "Q9TXS0", "WBGene00018974", "Q9N489", "WBGene00022453", "Q95XH1", "WBGene00022077", "G5EBK2", "WBGene00014084", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q19767", "WBGene00004898", "Q94057", "WBGene00044062", "Q9XZI6", "WBGene00006751", "Q9N532", "WBGene00003238", "G5EDV1", "WBGene00003006", "P34889", "WBGene00000858", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "Q9U7D5", "WBGene00001519", "P51485", "WBGene00000195", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "P90761", "WBGene00006777", "Q18453", "WBGene00004682", "Q9BI71", "WBGene00001329", "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "P29355", "WBGene00004774", "Q17796", "WBGene00004101", "O01498", "WBGene00004109", "Q21496", "WBGene00020010", "Q21948", "WBGene00020010", "A0A486WXX8", "WBGene00000894", "Q95QV2", "WBGene00000477", "Q19625", "WBGene00003412", "P34711", "WBGene00006756", "Q9XTT3", "WBGene00013039", "A0A0K3AS36", "Y116A8C.36d", "Q6AHQ8", "WBGene00018467", "Q8I4E2", "WBGene00003086", "Q02328", "WBGene00022717", "P0DM42", "WBGene00000065", "P10984", "WBGene00000064", "P10986", "WBGene00000066", "P0DM41", "WBGene00000063", "species_29358", "P58798", "WBGene00000204", "A0A3P6PCS5", "WBGene00000201", "Q9N4I0", "WBGene00000199", "Q8WTM6", "WBGene00021170", "P53489", "WBGene00000200", "Q9XWV3", "WBGene00000203", "O61861", "WBGene00000205", "P91167", "WBGene00016729", "Q19253", "WBGene00017298", "Q9XUS7", "WBGene00010663", "B1V8A0", "WBGene00006791", "Q21004", "WBGene00010272", "Q9BIF4", "WBGene00001224", "G5ECQ3", "WBGene00004762", "Q20483", "WBGene00018516", "species_179856", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "Q9TXS0", "WBGene00018974", "Q9N489", "WBGene00022453", "Q95XH1", "WBGene00022077", "G5EBK2", "WBGene00014084", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q19767", "WBGene00004898", "Q94057", "WBGene00044062", "Q9XZI6", "WBGene00006751", "Q9N532", "WBGene00003238", "G5EDV1", "WBGene00003006", "P34889", "WBGene00000858", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "Q9U7D5", "WBGene00001519", "P51485", "WBGene00000195", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "P90761", "WBGene00006777", "Q18453", "WBGene00004682", "Q9BI71", "WBGene00001329", "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "P29355", "WBGene00004774", "Q17796", "WBGene00004101", "O01498", "WBGene00004109", "Q21496", "WBGene00020010", "Q21948", "WBGene00020010", "A0A486WXX8", "WBGene00000894", "Q95QV2", "WBGene00000477", "Q19625", "WBGene00003412", "P34711", "WBGene00006756", "Q9XTT3", "WBGene00013039", "A0A0K3AS36", "Y116A8C.36d", "Q6AHQ8", "WBGene00018467", "Q8I4E2", "WBGene00003086", "P39055", "WBGene00001130", "species_29438" ] }, "reaction_10566480": { "compartment": "compartment_876", "id": "reaction_10566480", "reactome": "R-CEL-8868072", "name": "Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_392417" ], "products": [ "species_29370", "species_202247" ], "modifiers": [ [ "species_10566403", "catalyst" ] ], "additional_components": [ "G5ECQ3", "WBGene00004762", "Q20483", "WBGene00018516", "Q9BIF4", "WBGene00001224", "species_179856", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "Q9TXS0", "WBGene00018974", "Q9N489", "WBGene00022453", "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "Q19123", "WBGene00000157", "P35603", "WBGene00001082", "A0A0K3AS36", "Y116A8C.36d", "Q95XH1", "WBGene00022077", "G5EBK2", "WBGene00014084", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q19767", "WBGene00004898", "Q94057", "WBGene00044062", "Q9XZI6", "WBGene00006751", "Q9N532", "WBGene00003238", "G5EDV1", "WBGene00003006", "P34889", "WBGene00000858", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "Q9U7D5", "WBGene00001519", "P51485", "WBGene00000195", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "P90761", "WBGene00006777", "Q18453", "WBGene00004682", "Q9BI71", "WBGene00001329", "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "B1V8A0", "WBGene00006791", "P29355", "WBGene00004774", "Q17796", "WBGene00004101", "O01498", "WBGene00004109", "Q21496", "WBGene00020010", "Q21948", "WBGene00020010", "A0A486WXX8", "WBGene00000894", "Q95QV2", "WBGene00000477", "Q19625", "WBGene00003412", "P34711", "WBGene00006756", "Q9XTT3", "WBGene00013039", "G5EDY0", "WBGene00009552" ] }, "reaction_10566672": { "compartment": "compartment_24339", "id": "reaction_10566672", "reactome": "R-CEL-8868659", "name": "Clathrin recruits auxilins to the clathrin-coated vesicle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10566668", "species_10522393" ], "products": [ "species_10566670" ], "modifiers": [], "additional_components": [ "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q9XTT3", "WBGene00013039", "Q19625", "WBGene00003412", "Q95QV2", "WBGene00000477", "P34711", "WBGene00006756", "Q21496", "WBGene00020010", "Q21948", "WBGene00020010", "A0A486WXX8", "WBGene00000894", "O02495", "WBGene00004897", "G5EBK2", "WBGene00014084", "P34351", "WBGene00004899", "Q19767", "WBGene00004898", "Q94057", "WBGene00044062", "Q95XH1", "WBGene00022077", "Q9XZI6", "WBGene00006751", "Q9BIF4", "WBGene00001224", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "B1V8A0", "WBGene00006791", "Q18453", "WBGene00004682", "Q9BI71", "WBGene00001329", "P29355", "WBGene00004774", "Q17796", "WBGene00004101", "O01498", "WBGene00004109", "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "P34889", "WBGene00000858", "G5EDV1", "WBGene00003006", "Q9N532", "WBGene00003238", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "Q9U7D5", "WBGene00001519", "P51485", "WBGene00000195", "P90761", "WBGene00006777", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "Q02328", "WBGene00022717", "G5ECQ3", "WBGene00004762", "Q20483", "WBGene00018516", "P0DM42", "WBGene00000065", "P10984", "WBGene00000064", "P10986", "WBGene00000066", "P0DM41", "WBGene00000063", "species_29358", "Q19253", "WBGene00017298", "P58798", "WBGene00000204", "A0A3P6PCS5", "WBGene00000201", "Q9N4I0", "WBGene00000199", "Q8WTM6", "WBGene00021170", "P53489", "WBGene00000200", "Q9XWV3", "WBGene00000203", "O61861", "WBGene00000205", "P91167", "WBGene00016729", "species_1806234", "Q21004", "WBGene00010272", "Q9XUS7", "WBGene00010663", "Q9TXS0", "WBGene00018974", "Q6AHQ8", "WBGene00018467", "Q9N489", "WBGene00022453", "Q8I4E2", "WBGene00003086", "A0A0K3AS36", "Y116A8C.36d", "P39055", "WBGene00001130", "species_29420", "O17590", "WBGene00007620", "G5ECL2", "WBGene00006763", "WBGene00001043", "Q02328", "WBGene00022717", "G5ECQ3", "WBGene00004762", "Q20483", "WBGene00018516", "Q19253", "WBGene00017298", "P58798", "WBGene00000204", "A0A3P6PCS5", "WBGene00000201", "Q9N4I0", "WBGene00000199", "species_29358", "Q8WTM6", "WBGene00021170", "P53489", "WBGene00000200", "Q9XWV3", "WBGene00000203", "O61861", "WBGene00000205", "P91167", "WBGene00016729", "Q9XUS7", "WBGene00010663", "B1V8A0", "WBGene00006791", "Q9TXS0", "WBGene00018974", "Q9N489", "WBGene00022453", "A0A0K3AS36", "Y116A8C.36d", "P39055", "WBGene00001130", "species_29420", "O17590", "WBGene00007620", "G5ECL2", "WBGene00006763", "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q9XTT3", "WBGene00013039", "Q19625", "WBGene00003412", "Q95QV2", "WBGene00000477", "P34711", "WBGene00006756", "Q21496", "WBGene00020010", "Q21948", "WBGene00020010", "A0A486WXX8", "WBGene00000894", "O02495", "WBGene00004897", "G5EBK2", "WBGene00014084", "P34351", "WBGene00004899", "Q19767", "WBGene00004898", "Q94057", "WBGene00044062", "Q95XH1", "WBGene00022077", "Q9XZI6", "WBGene00006751", "Q9BIF4", "WBGene00001224", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "Q18453", "WBGene00004682", "Q9BI71", "WBGene00001329", "P29355", "WBGene00004774", "Q17796", "WBGene00004101", "O01498", "WBGene00004109", "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "P34889", "WBGene00000858", "G5EDV1", "WBGene00003006", "Q9N532", "WBGene00003238", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "Q9U7D5", "WBGene00001519", "P51485", "WBGene00000195", "P90761", "WBGene00006777", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "P0DM42", "WBGene00000065", "P10984", "WBGene00000064", "P10986", "WBGene00000066", "P0DM41", "WBGene00000063", "species_1806234", "Q21004", "WBGene00010272", "A0A486WXP9", "WBGene00001043", "Q6AHQ8", "WBGene00018467", "Q8I4E2", "WBGene00003086" ] }, "reaction_10566674": { "compartment": "compartment_24339", "id": "reaction_10566674", "reactome": "R-CEL-8868660", "name": "Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10565761" ], "products": [ "species_29370", "species_10565777" ], "modifiers": [ [ "species_10565761", "catalyst" ] ], "additional_components": [ "G5ECQ3", "WBGene00004762", "Q20483", "WBGene00018516", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "Q9BIF4", "WBGene00001224", "species_179856", "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q9TXS0", "WBGene00018974", "A0A0K3AS36", "Y116A8C.36d", "Q9N489", "WBGene00022453", "G5ECQ3", "WBGene00004762", "Q20483", "WBGene00018516", "Q9BIF4", "WBGene00001224", "species_179856", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "Q9TXS0", "WBGene00018974", "Q9N489", "WBGene00022453", "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "Q19123", "WBGene00000157", "P35603", "WBGene00001082", "A0A0K3AS36", "Y116A8C.36d", "G5ECQ3", "WBGene00004762", "Q20483", "WBGene00018516", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "Q9BIF4", "WBGene00001224", "species_179856", "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q9TXS0", "WBGene00018974", "A0A0K3AS36", "Y116A8C.36d", "Q9N489", "WBGene00022453" ] }, "reaction_10566523": { "compartment": "compartment_876", "id": "reaction_10566523", "reactome": "R-CEL-8868648", "name": "SYNJ hydrolyze PI(4,5)P2 to PI(4)P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10566518" ], "products": [ "species_29372", "species_10566520" ], "modifiers": [ [ "species_10566518", "catalyst" ] ], "additional_components": [ "Q02328", "WBGene00022717", "P0DM42", "WBGene00000065", "P10984", "WBGene00000064", "P10986", "WBGene00000066", "P0DM41", "WBGene00000063", "species_29358", "P58798", "WBGene00000204", "A0A3P6PCS5", "WBGene00000201", "Q9N4I0", "WBGene00000199", "Q8WTM6", "WBGene00021170", "P53489", "WBGene00000200", "Q9XWV3", "WBGene00000203", "O61861", "WBGene00000205", "P91167", "WBGene00016729", "Q19253", "WBGene00017298", "Q9XUS7", "WBGene00010663", "B1V8A0", "WBGene00006791", "Q21004", "WBGene00010272", "Q9BIF4", "WBGene00001224", "G5ECQ3", "WBGene00004762", "Q20483", "WBGene00018516", "species_179856", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "Q9TXS0", "WBGene00018974", "Q9N489", "WBGene00022453", "Q95XH1", "WBGene00022077", 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10537150", "species_10566506" ], "products": [ "species_10566518" ], "modifiers": [], "additional_components": [ "O17590", "WBGene00007620", "G5ECL2", "WBGene00006763", "Q02328", "WBGene00022717", "P0DM42", "WBGene00000065", "P10984", "WBGene00000064", "P10986", "WBGene00000066", "P0DM41", "WBGene00000063", "species_29358", "P58798", "WBGene00000204", "A0A3P6PCS5", "WBGene00000201", "Q9N4I0", "WBGene00000199", "Q8WTM6", "WBGene00021170", "P53489", "WBGene00000200", "Q9XWV3", "WBGene00000203", "O61861", "WBGene00000205", "P91167", "WBGene00016729", "Q19253", "WBGene00017298", "Q9XUS7", "WBGene00010663", "B1V8A0", "WBGene00006791", "Q21004", "WBGene00010272", "Q9BIF4", "WBGene00001224", "G5ECQ3", "WBGene00004762", "Q20483", "WBGene00018516", "species_179856", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "Q9TXS0", "WBGene00018974", "Q9N489", "WBGene00022453", "Q95XH1", "WBGene00022077", "G5EBK2", "WBGene00014084", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q19767", "WBGene00004898", "Q94057", "WBGene00044062", "Q9XZI6", "WBGene00006751", "Q9N532", "WBGene00003238", "G5EDV1", "WBGene00003006", "P34889", "WBGene00000858", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "Q9U7D5", "WBGene00001519", "P51485", "WBGene00000195", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "P90761", "WBGene00006777", "Q18453", "WBGene00004682", "Q9BI71", "WBGene00001329", "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "P29355", "WBGene00004774", "Q17796", "WBGene00004101", "O01498", "WBGene00004109", "Q21496", "WBGene00020010", "Q21948", "WBGene00020010", "A0A486WXX8", "WBGene00000894", "Q95QV2", "WBGene00000477", "Q19625", "WBGene00003412", "P34711", "WBGene00006756", "Q9XTT3", "WBGene00013039", "A0A0K3AS36", "Y116A8C.36d", "Q6AHQ8", "WBGene00018467", "Q8I4E2", "WBGene00003086", "P39055", "WBGene00001130", "species_29438", "Q02328", "WBGene00022717", "P0DM42", "WBGene00000065", "P10984", "WBGene00000064", "P10986", "WBGene00000066", "P0DM41", "WBGene00000063", "species_29358", "P58798", "WBGene00000204", "A0A3P6PCS5", "WBGene00000201", "Q9N4I0", "WBGene00000199", "Q8WTM6", "WBGene00021170", "P53489", "WBGene00000200", "Q9XWV3", "WBGene00000203", "O61861", "WBGene00000205", "P91167", "WBGene00016729", "Q19253", "WBGene00017298", "Q9XUS7", "WBGene00010663", "B1V8A0", "WBGene00006791", "Q21004", "WBGene00010272", "Q9BIF4", "WBGene00001224", "G5ECQ3", "WBGene00004762", "Q20483", "WBGene00018516", "species_179856", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "Q9TXS0", "WBGene00018974", "Q9N489", "WBGene00022453", "Q95XH1", "WBGene00022077", "G5EBK2", "WBGene00014084", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q19767", "WBGene00004898", "Q94057", "WBGene00044062", "Q9XZI6", "WBGene00006751", "Q9N532", "WBGene00003238", "G5EDV1", "WBGene00003006", "P34889", "WBGene00000858", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "Q9U7D5", "WBGene00001519", "P51485", "WBGene00000195", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "P90761", "WBGene00006777", "Q18453", "WBGene00004682", "Q9BI71", "WBGene00001329", "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "P29355", "WBGene00004774", "Q17796", "WBGene00004101", "O01498", "WBGene00004109", "Q21496", "WBGene00020010", "Q21948", "WBGene00020010", "A0A486WXX8", "WBGene00000894", "Q95QV2", "WBGene00000477", "Q19625", "WBGene00003412", "P34711", "WBGene00006756", "Q9XTT3", "WBGene00013039", "A0A0K3AS36", "Y116A8C.36d", "Q6AHQ8", "WBGene00018467", "Q8I4E2", "WBGene00003086", "P39055", "WBGene00001130", "species_29438", "O17590", "WBGene00007620", "G5ECL2", "WBGene00006763" ] }, "reaction_10566462": { "compartment": "compartment_876", "id": "reaction_10566462", "reactome": "R-CEL-8867754", "name": "F- and N- BAR domain proteins bind the clathrin-coated pit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10566428", "species_10566426", "species_10566456", "species_10566409", "species_10566437", "species_10512243", "species_10566403", "species_10566448" ], "products": [ "species_10565743", "species_10566460", "species_10537176" ], "modifiers": [ [ "species_202247", "catalyst" ] ], "additional_components": [ "WBGene00003086", "Q6AHQ8", "WBGene00018467", "Q19253", "WBGene00017298", "Q9XUS7", "WBGene00010663", "Q21004", "WBGene00010272", "Q19253", "WBGene00017298", "B1V8A0", "WBGene00006791", "G5ECQ3", "WBGene00004762", "Q20483", "WBGene00018516", "Q9BIF4", "WBGene00001224", "species_179856", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "Q9TXS0", "WBGene00018974", "Q9N489", "WBGene00022453", "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "Q19123", "WBGene00000157", "P35603", "WBGene00001082", "A0A0K3AS36", "Y116A8C.36d", "Q95XH1", "WBGene00022077", "G5EBK2", "WBGene00014084", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q19767", "WBGene00004898", "Q94057", "WBGene00044062", "Q9XZI6", "WBGene00006751", "Q9N532", "WBGene00003238", "G5EDV1", "WBGene00003006", "P34889", "WBGene00000858", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "Q9U7D5", "WBGene00001519", "P51485", "WBGene00000195", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "P90761", "WBGene00006777", "Q18453", "WBGene00004682", "Q9BI71", "WBGene00001329", "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "B1V8A0", "WBGene00006791", "P29355", "WBGene00004774", "Q17796", "WBGene00004101", "O01498", "WBGene00004109", "Q21496", "WBGene00020010", "Q21948", "WBGene00020010", "A0A486WXX8", "WBGene00000894", "Q95QV2", "WBGene00000477", "Q19625", "WBGene00003412", "P34711", "WBGene00006756", "Q9XTT3", "WBGene00013039", "G5EDY0", "WBGene00009552", "Q19253", "WBGene00017298", "Q9XUS7", "WBGene00010663", "Q9TXS0", "WBGene00018974", "Q19253", "WBGene00017298", "Q9XUS7", "WBGene00010663", "B1V8A0", "WBGene00006791", "Q21004", "WBGene00010272", "Q9BIF4", "WBGene00001224", "G5ECQ3", "WBGene00004762", "Q20483", "WBGene00018516", "species_179856", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "Q9TXS0", "WBGene00018974", "Q9N489", "WBGene00022453", "Q95XH1", "WBGene00022077", "G5EBK2", "WBGene00014084", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q19767", "WBGene00004898", "Q94057", "WBGene00044062", "Q9XZI6", "WBGene00006751", "Q9N532", "WBGene00003238", "G5EDV1", "WBGene00003006", "P34889", "WBGene00000858", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "Q9U7D5", "WBGene00001519", "P51485", "WBGene00000195", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "P90761", "WBGene00006777", "Q18453", "WBGene00004682", "Q9BI71", "WBGene00001329", "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "P29355", "WBGene00004774", "Q17796", "WBGene00004101", "O01498", "WBGene00004109", "Q21496", "WBGene00020010", "Q21948", "WBGene00020010", "A0A486WXX8", "WBGene00000894", "Q95QV2", "WBGene00000477", "Q19625", "WBGene00003412", "P34711", "WBGene00006756", "Q9XTT3", "WBGene00013039", "A0A0K3AS36", "Y116A8C.36d", "Q6AHQ8", "WBGene00018467", "Q8I4E2", "WBGene00003086", "WBGene00009552" ] }, "reaction_10552405": { "compartment": "compartment_70101", "id": "reaction_10552405", "reactome": "R-CEL-5577213", "name": "LTCC multimer transports Ca2+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74112" ], "products": [ "species_74016" ], "modifiers": [ [ "species_10552402", "catalyst" ] ], "additional_components": [ "G5EG74", "WBGene00007041", "P34374", "WBGene00006772", "G5EBI8", "WBGene00017400", "G5EDT2", "WBGene00007670", "Q8MQA1", "WBGene00001187", "A0A078BQJ0", "WBGene00021125", "O01661", "WBGene00000368" ] }, "reaction_10552761": { "compartment": "compartment_70101", "id": "reaction_10552761", "reactome": "R-CEL-5617179", "name": "PRKACA phosphorylates TNNI3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10552741" ], "products": [ "species_29370", "species_10552759" ], "modifiers": [ [ "species_10508954", "catalyst" ] ], "additional_components": [ "Q9XUN9", "WBGene00006585", "O44572", "WBGene00006586", "Q20334", "WBGene00006584", "Q9GYF1", "WBGene00006764", "Q9GYF1", "WBGene00006764", "Q9XUN9", "WBGene00006585", "O44572", "WBGene00006586", "Q20334", "WBGene00006584", "WBGene00002189" ] }, "reaction_10524944": { "compartment": "compartment_70101", "id": "reaction_10524944", "reactome": "R-CEL-445700", "name": "Myosin Binds ATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10524942", "species_113592" ], "products": [ "species_10524933" ], "modifiers": [], "additional_components": [ "Q20641", "WBGene00003776", "Q8I7M7", "WBGene00006582", "O01479", "WBGene00006823", "P0DM41", "WBGene00000063", "P0DM42", "WBGene00000065", "P10984", "WBGene00000064", "P10986", "WBGene00000066", "species_74016", "Q22866", "WBGene00002978", "P19625", "WBGene00003369", "P19626", "WBGene00003370", "Q09510", "WBGene00003372", "Q20238", "WBGene00009585", "Q21201", "WBGene00010554", "Q69Z12", "WBGene00023451", "Q9XVI9", "WBGene00011734", "P53014", "WBGene00003371", "G5EGK1", "WBGene00006771", "P19826", "WBGene00000942", "G5EC32", "WBGene00012891", "P34446", "WBGene00003929", "Q20641", "WBGene00003776", "species_29358", "P19625", "WBGene00003369", "P19626", "WBGene00003370", "Q09510", "WBGene00003372", "Q20238", "WBGene00009585", "Q21201", "WBGene00010554", "Q69Z12", "WBGene00023451", "Q9XVI9", "WBGene00011734", "P53014", "WBGene00003371", "Q8I7M7", "WBGene00006582", "O01479", "WBGene00006823", "P0DM41", "WBGene00000063", "P0DM42", "WBGene00000065", "P10984", "WBGene00000064", "P10986", "WBGene00000066", "species_74016", "Q22866", "WBGene00002978", "G5EGK1", "WBGene00006771", "P19826", "WBGene00000942", "G5EC32", "WBGene00012891", "P34446", "WBGene00003929" ] }, "reaction_10524948": { "compartment": "compartment_70101", "id": "reaction_10524948", "reactome": "R-CEL-445704", "name": "Calcium Binds Caldesmon", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10524946", "species_74016" ], "products": [ "species_10524942" ], "modifiers": [], "additional_components": [ "Q20641", "WBGene00003776", "Q8I7M7", "WBGene00006582", "O01479", "WBGene00006823", "P0DM41", "WBGene00000063", "P0DM42", "WBGene00000065", "P10984", "WBGene00000064", "P10986", "WBGene00000066", "Q22866", "WBGene00002978", "P19625", "WBGene00003369", "P19626", "WBGene00003370", "Q09510", "WBGene00003372", "Q20238", "WBGene00009585", "Q21201", "WBGene00010554", "Q69Z12", "WBGene00023451", "Q9XVI9", "WBGene00011734", "P53014", "WBGene00003371", "G5EGK1", "WBGene00006771", "P19826", "WBGene00000942", "G5EC32", "WBGene00012891", "P34446", "WBGene00003929", "Q20641", "WBGene00003776", "Q8I7M7", "WBGene00006582", "O01479", "WBGene00006823", "P0DM41", "WBGene00000063", "P0DM42", "WBGene00000065", "P10984", "WBGene00000064", "P10986", "WBGene00000066", "species_74016", "Q22866", "WBGene00002978", "P19625", "WBGene00003369", "P19626", "WBGene00003370", "Q09510", "WBGene00003372", "Q20238", "WBGene00009585", "Q21201", "WBGene00010554", "Q69Z12", "WBGene00023451", "Q9XVI9", "WBGene00011734", "P53014", "WBGene00003371", "G5EGK1", "WBGene00006771", "P19826", "WBGene00000942", "G5EC32", "WBGene00012891", "P34446", "WBGene00003929" ] }, "reaction_10524950": { "compartment": "compartment_70101", "id": "reaction_10524950", "reactome": "R-CEL-445705", "name": "Release Of ADP From Myosin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10524937" ], "products": [ "species_10524942", "species_29370" ], "modifiers": [], "additional_components": [ "Q8I7M7", "WBGene00006582", "O01479", "WBGene00006823", "P0DM41", "WBGene00000063", "P0DM42", "WBGene00000065", "P10984", "WBGene00000064", "P10986", "WBGene00000066", "species_74016", "Q20641", "WBGene00003776", "species_113582", "P19625", "WBGene00003369", "P19626", "WBGene00003370", "Q09510", "WBGene00003372", "Q20238", "WBGene00009585", "Q21201", "WBGene00010554", "Q69Z12", "WBGene00023451", "Q9XVI9", "WBGene00011734", "P53014", "WBGene00003371", "Q22866", "WBGene00002978", "G5EGK1", "WBGene00006771", "P19826", "WBGene00000942", "G5EC32", "WBGene00012891", "P34446", "WBGene00003929", "Q20641", "WBGene00003776", "Q8I7M7", "WBGene00006582", "O01479", "WBGene00006823", "P0DM41", "WBGene00000063", "P0DM42", "WBGene00000065", "P10984", "WBGene00000064", "P10986", "WBGene00000066", "species_74016", "Q22866", "WBGene00002978", "P19625", "WBGene00003369", "P19626", "WBGene00003370", "Q09510", "WBGene00003372", "Q20238", "WBGene00009585", "Q21201", "WBGene00010554", "Q69Z12", "WBGene00023451", "Q9XVI9", "WBGene00011734", "P53014", "WBGene00003371", "G5EGK1", "WBGene00006771", "P19826", "WBGene00000942", "G5EC32", "WBGene00012891", "P34446", "WBGene00003929" ] }, "reaction_10524940": { "compartment": "compartment_70101", "id": "reaction_10524940", "reactome": "R-CEL-445699", "name": "ATP Hydrolysis By Myosin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10524933" ], "products": [ "species_29372", "species_10524937" ], "modifiers": [ [ "species_10524866", "catalyst" ] ], "additional_components": [ "Q20641", "WBGene00003776", "species_29358", "P19625", "WBGene00003369", "P19626", "WBGene00003370", "Q09510", "WBGene00003372", "Q20238", "WBGene00009585", "Q21201", "WBGene00010554", "Q69Z12", "WBGene00023451", "Q9XVI9", "WBGene00011734", "P53014", "WBGene00003371", "Q8I7M7", "WBGene00006582", "O01479", "WBGene00006823", "P0DM41", "WBGene00000063", "P0DM42", "WBGene00000065", "P10984", "WBGene00000064", "P10986", "WBGene00000066", "species_74016", "Q22866", "WBGene00002978", "G5EGK1", "WBGene00006771", "P19826", "WBGene00000942", "G5EC32", "WBGene00012891", "P34446", "WBGene00003929", "Q8I7M7", "WBGene00006582", "O01479", "WBGene00006823", "P0DM41", "WBGene00000063", "P0DM42", "WBGene00000065", "P10984", "WBGene00000064", "P10986", "WBGene00000066", "species_74016", "Q20641", "WBGene00003776", "species_113582", "P19625", "WBGene00003369", "P19626", "WBGene00003370", "Q09510", "WBGene00003372", "Q20238", "WBGene00009585", "Q21201", "WBGene00010554", "Q69Z12", "WBGene00023451", "Q9XVI9", "WBGene00011734", "P53014", "WBGene00003371", "Q22866", "WBGene00002978", "G5EGK1", "WBGene00006771", "P19826", "WBGene00000942", "G5EC32", "WBGene00012891", "P34446", "WBGene00003929", "Q20641", "WBGene00003776", "species_29358", "P19625", "WBGene00003369", "P19626", "WBGene00003370", "Q09510", "WBGene00003372", "Q20238", "WBGene00009585", "Q21201", "WBGene00010554", "Q69Z12", "WBGene00023451", "Q9XVI9", "WBGene00011734", "P53014", "WBGene00003371" ] }, "reaction_10551263": { "compartment": "compartment_437051", "id": "reaction_10551263", "reactome": "R-CEL-5263633", "name": "DYSF, CAV3 and TRIM72 bind", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10551259", "species_10551257", "species_10551252" ], "products": [ "species_10551261" ], "modifiers": [ [ "species_74016", "catalyst" ] ], "additional_components": [ "WBGene00021640", "WBGene00001414", "WBGene00000302", "Q18879", "WBGene00000302", "Q17388", "WBGene00001414", "Q9N3T6", "WBGene00021640" ] }, "reaction_10517408": { "compartment": "compartment_984", "id": "reaction_10517408", "reactome": "R-CEL-216058", "name": "Integrin alpha7beta1 binds Laminin-211, 221, 411, 512, 521", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10517404", "species_10517402" ], "products": [ "species_10517406" ], "modifiers": [], "additional_components": [ "Q18823", "WBGene00016913", "O44565", "WBGene00002247", "G5ECE3", "WBGene00002248", "Q21313", "WBGene00001328", "Q27874", "WBGene00003930", "Q03600", "WBGene00002081", "Q27874", "WBGene00003930", "Q03600", "WBGene00002081", "Q18823", "WBGene00016913", "O44565", "WBGene00002247", "G5ECE3", "WBGene00002248", "Q21313", "WBGene00001328" ] }, "reaction_10517382": { "compartment": "compartment_984", "id": "reaction_10517382", "reactome": "R-CEL-216048", "name": "Integrins alpha3beta1, alpha6beta4 bind laminin-332, 511, 521, (211, 221)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10517378", "species_10517313" ], "products": [ "species_10517380" ], "modifiers": [], "additional_components": [ "Q18823", "WBGene00016913", "Q21313", "WBGene00001328", "O44565", "WBGene00002247", "Q19981", "WBGene00006432", "G5EG68", "WBGene00018304", "Q06561", "WBGene00006787", "G5ECE3", "WBGene00002248", "Q03600", "WBGene00002081", "Q27874", "WBGene00003930", "Q03600", "WBGene00002081", "Q27874", "WBGene00003930", "Q18823", "WBGene00016913", "Q21313", "WBGene00001328", "O44565", "WBGene00002247", "Q19981", "WBGene00006432", "G5EG68", "WBGene00018304", "Q06561", "WBGene00006787", "G5ECE3", "WBGene00002248" ] }, "reaction_10548376": { "compartment": "compartment_876", "id": "reaction_10548376", "reactome": "R-CEL-3907292", "name": "Integrin alpha6beta1 binds laminin-322, 512, 521, 211, 221, 411", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10548372", "species_10548370" ], "products": [ "species_10548374" ], "modifiers": [], "additional_components": [ "Q18823", "WBGene00016913", "O44565", "WBGene00002247", "G5ECE3", "WBGene00002248", "Q21313", "WBGene00001328", "Q19981", "WBGene00006432", "G5EG68", "WBGene00018304", "Q06561", "WBGene00006787", "Q27874", "WBGene00003930", "Q03600", "WBGene00002081", "Q27874", "WBGene00003930", "Q03600", "WBGene00002081", "Q18823", "WBGene00016913", "O44565", "WBGene00002247", "G5ECE3", "WBGene00002248", "Q21313", "WBGene00001328", "Q19981", "WBGene00006432", "G5EG68", "WBGene00018304", "Q06561", "WBGene00006787" ] }, "reaction_10517896": { "compartment": "compartment_984", "id": "reaction_10517896", "reactome": "R-CEL-349626", "name": "Integrin alpha2beta1 binds laminin-332", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10517354", "species_10517892" ], "products": [ "species_10517894" ], "modifiers": [], "additional_components": [ "O44565", "WBGene00002247", "Q18823", "WBGene00016913", "Q19981", "WBGene00006432", "G5EG68", "WBGene00018304", "Q06561", "WBGene00006787", "G5ECE3", "WBGene00002248", "Q21313", "WBGene00001328", "P34446", "WBGene00003929", "Q27874", "WBGene00003930", "P34446", "WBGene00003929", "Q27874", "WBGene00003930", "O44565", "WBGene00002247", "Q18823", "WBGene00016913", "Q19981", "WBGene00006432", "G5EG68", "WBGene00018304", "Q06561", "WBGene00006787", "G5ECE3", "WBGene00002248", "Q21313", "WBGene00001328" ] }, "reaction_10548927": { "compartment": "compartment_984", "id": "reaction_10548927", "reactome": "R-CEL-4084507", "name": "Laminin-111 binds endostatin dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10548923", "species_10544249" ], "products": [ "species_10548925" ], "modifiers": [], "additional_components": [ "Q19368", "WBGene00000702", "Q18823", "WBGene00016913", "G5ECE3", "WBGene00002248", "Q21313", "WBGene00001328", "O44565", "WBGene00002247", "Q18823", "WBGene00016913", "G5ECE3", "WBGene00002248", "Q21313", "WBGene00001328", "O44565", "WBGene00002247", "Q19368", "WBGene00000702" ] }, "reaction_10572433": { "compartment": "compartment_17938", "id": "reaction_10572433", "reactome": "R-CEL-9639286", "name": "RRAGC,D exchanges GTP for GDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29420", "species_10572426" ], "products": [ "species_10572430", "species_29438" ], "modifiers": [ [ "species_10572426", "catalyst" ] ], "additional_components": [ "species_29420", "Q22743", "WBGene00006414", "G5EGB3", "WBGene00012497", "species_29438", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "Q9XXU9", "WBGene00006920", "Q22494", "WBGene00020507", "Q23680", "WBGene00006918", "P34462", "WBGene00010130", "Q9XW92", "WBGene00013025", "Q19626", "WBGene00006921", "Q9N5A0", "WBGene00004959", "Q95X44", "WBGene00006917", "P91303", "WBGene00006919", "C0HLB3", "WBGene00006911", "C0HLB4", "WBGene00006912", "Q95YD5", "WBGene00016258", "G5EEK9", "WBGene00006914", "G5EGP4", "WBGene00006915", "P30628", "WBGene00006768", "B2MZD0", "WBGene00006916", "Q20591", "WBGene00009882", "G5EDB8", "WBGene00006913", "species_29420", "Q22743", "WBGene00006414", "G5EGB3", "WBGene00012497", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "Q9XXU9", "WBGene00006920", "Q22494", "WBGene00020507", "Q23680", "WBGene00006918", "P34462", "WBGene00010130", "Q9XW92", "WBGene00013025", "Q19626", "WBGene00006921", "Q9N5A0", "WBGene00004959", "Q95X44", "WBGene00006917", "P91303", "WBGene00006919", "C0HLB3", "WBGene00006911", "C0HLB4", "WBGene00006912", "Q95YD5", "WBGene00016258", "G5EEK9", "WBGene00006914", "G5EGP4", "WBGene00006915", "P30628", "WBGene00006768", "B2MZD0", "WBGene00006916", "Q20591", "WBGene00009882", "G5EDB8", "WBGene00006913", "species_29420", "Q22743", "WBGene00006414", "G5EGB3", "WBGene00012497", "species_29438", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "Q9XXU9", "WBGene00006920", "Q22494", "WBGene00020507", "Q23680", "WBGene00006918", "P34462", "WBGene00010130", "Q9XW92", "WBGene00013025", "Q19626", "WBGene00006921", "Q9N5A0", "WBGene00004959", "Q95X44", "WBGene00006917", "P91303", "WBGene00006919", "C0HLB3", "WBGene00006911", "C0HLB4", "WBGene00006912", "Q95YD5", "WBGene00016258", "G5EEK9", "WBGene00006914", "G5EGP4", "WBGene00006915", "P30628", "WBGene00006768", "B2MZD0", "WBGene00006916", "Q20591", "WBGene00009882", "G5EDB8", "WBGene00006913" ] }, "reaction_10572545": { "compartment": "compartment_17938", "id": "reaction_10572545", "reactome": "R-CEL-9645608", "name": "v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10510526", "species_10572439" ], "products": [ "species_10572450" ], "modifiers": [], "additional_components": [ "P91040", "WBGene00015697", "Q95Q95", "WBGene00002583", "Q68TI8", "WBGene00000911", "species_29420", "G5EGB3", "WBGene00012497", "Q22743", "WBGene00006414", "species_29438", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "Q9XXU9", "WBGene00006920", "Q22494", "WBGene00020507", "Q23680", "WBGene00006918", "P34462", "WBGene00010130", "Q9XW92", "WBGene00013025", "Q19626", "WBGene00006921", "Q9N5A0", "WBGene00004959", "Q95X44", "WBGene00006917", "P91303", "WBGene00006919", "C0HLB3", "WBGene00006911", "C0HLB4", "WBGene00006912", "Q95YD5", "WBGene00016258", "G5EEK9", "WBGene00006914", "G5EGP4", "WBGene00006915", "P30628", "WBGene00006768", "B2MZD0", "WBGene00006916", "Q20591", "WBGene00009882", "G5EDB8", "WBGene00006913", "species_29420", "G5EGB3", "WBGene00012497", "Q22743", "WBGene00006414", "species_29438", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "Q9XXU9", "WBGene00006920", "Q22494", "WBGene00020507", "Q23680", "WBGene00006918", "P34462", "WBGene00010130", "Q9XW92", "WBGene00013025", "Q19626", "WBGene00006921", "Q9N5A0", "WBGene00004959", "Q95X44", "WBGene00006917", "P91303", "WBGene00006919", "C0HLB3", "WBGene00006911", "C0HLB4", "WBGene00006912", "Q95YD5", "WBGene00016258", "G5EEK9", "WBGene00006914", "G5EGP4", "WBGene00006915", "P30628", "WBGene00006768", "B2MZD0", "WBGene00006916", "Q20591", "WBGene00009882", "G5EDB8", "WBGene00006913", "P91040", "WBGene00015697", "Q95Q95", "WBGene00002583", "Q68TI8", "WBGene00000911" ] }, "reaction_10572448": { "compartment": "compartment_17938", "id": "reaction_10572448", "reactome": "R-CEL-9640175", "name": "v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10572430", "species_10572435" ], "products": [ "species_10572437" ], "modifiers": [], "additional_components": [ "species_29420", "Q22743", "WBGene00006414", "G5EGB3", "WBGene00012497", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "Q9XXU9", "WBGene00006920", "Q22494", "WBGene00020507", "Q23680", "WBGene00006918", "P34462", "WBGene00010130", "Q9XW92", "WBGene00013025", "Q19626", "WBGene00006921", "Q9N5A0", "WBGene00004959", "Q95X44", "WBGene00006917", "P91303", "WBGene00006919", "C0HLB3", "WBGene00006911", "C0HLB4", "WBGene00006912", "Q95YD5", "WBGene00016258", "G5EEK9", "WBGene00006914", "G5EGP4", "WBGene00006915", "P30628", "WBGene00006768", "B2MZD0", "WBGene00006916", "Q20591", "WBGene00009882", "G5EDB8", "WBGene00006913", "Q19425", "WBGene00008774", "species_29468", "Q19425", "WBGene00008774", "species_29468", "species_29420", "Q22743", "WBGene00006414", "G5EGB3", "WBGene00012497", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "Q9XXU9", "WBGene00006920", "Q22494", "WBGene00020507", "Q23680", "WBGene00006918", "P34462", "WBGene00010130", "Q9XW92", "WBGene00013025", "Q19626", "WBGene00006921", "Q9N5A0", "WBGene00004959", "Q95X44", "WBGene00006917", "P91303", "WBGene00006919", "C0HLB3", "WBGene00006911", "C0HLB4", "WBGene00006912", "Q95YD5", "WBGene00016258", "G5EEK9", "WBGene00006914", "G5EGP4", "WBGene00006915", "P30628", "WBGene00006768", "B2MZD0", "WBGene00006916", "Q20591", "WBGene00009882", "G5EDB8", "WBGene00006913" ] }, "reaction_10572553": { "compartment": "compartment_17938", "id": "reaction_10572553", "reactome": "R-CEL-9646468", "name": "mTORC1 binds RHEB:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10510507", "species_10572450" ], "products": [ "species_10572452" ], "modifiers": [], "additional_components": [ "P34443", "WBGene00010038", "species_29438", "species_29420", "G5EGB3", "WBGene00012497", "Q22743", "WBGene00006414", "species_29438", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "Q9XXU9", "WBGene00006920", "Q22494", "WBGene00020507", "Q23680", "WBGene00006918", "P34462", "WBGene00010130", "Q9XW92", "WBGene00013025", "Q19626", "WBGene00006921", "Q9N5A0", "WBGene00004959", "Q95X44", "WBGene00006917", "P91303", "WBGene00006919", "C0HLB3", "WBGene00006911", "C0HLB4", "WBGene00006912", "Q95YD5", "WBGene00016258", "G5EEK9", "WBGene00006914", "G5EGP4", "WBGene00006915", "P30628", "WBGene00006768", "B2MZD0", "WBGene00006916", "Q20591", "WBGene00009882", "G5EDB8", "WBGene00006913", "P91040", "WBGene00015697", "Q95Q95", "WBGene00002583", "Q68TI8", "WBGene00000911", "species_29420", "G5EGB3", "WBGene00012497", "Q22743", "WBGene00006414", "species_29438", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "Q9XXU9", "WBGene00006920", "Q22494", "WBGene00020507", "Q23680", "WBGene00006918", "P34462", "WBGene00010130", "Q9XW92", "WBGene00013025", "Q19626", "WBGene00006921", "Q9N5A0", "WBGene00004959", "Q95X44", "WBGene00006917", "P91303", "WBGene00006919", "C0HLB3", "WBGene00006911", "C0HLB4", "WBGene00006912", "Q95YD5", "WBGene00016258", "G5EEK9", "WBGene00006914", "G5EGP4", "WBGene00006915", "P30628", "WBGene00006768", "B2MZD0", "WBGene00006916", "Q20591", "WBGene00009882", "G5EDB8", "WBGene00006913", "P91040", "WBGene00015697", "Q95Q95", "WBGene00002583", "Q68TI8", "WBGene00000911", "P34443", "WBGene00010038" ] }, "reaction_10572457": { "compartment": "compartment_17938", "id": "reaction_10572457", "reactome": "R-CEL-9640195", "name": "RRAGA,B hydrolyzes GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10572452" ], "products": [ "species_29372", "species_10572454" ], "modifiers": [ [ "species_10572452", "catalyst" ] ], "additional_components": [ "species_29420", "G5EGB3", "WBGene00012497", "Q22743", "WBGene00006414", "species_29438", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "Q9XXU9", "WBGene00006920", "Q22494", "WBGene00020507", "Q23680", "WBGene00006918", "P34462", "WBGene00010130", "Q9XW92", "WBGene00013025", "Q19626", "WBGene00006921", "Q9N5A0", "WBGene00004959", "Q95X44", "WBGene00006917", "P91303", "WBGene00006919", "C0HLB3", "WBGene00006911", "C0HLB4", "WBGene00006912", "Q95YD5", "WBGene00016258", "G5EEK9", "WBGene00006914", "G5EGP4", "WBGene00006915", "P30628", "WBGene00006768", "B2MZD0", "WBGene00006916", "Q20591", "WBGene00009882", "G5EDB8", "WBGene00006913", "P91040", "WBGene00015697", "Q95Q95", "WBGene00002583", "Q68TI8", "WBGene00000911", "P34443", "WBGene00010038", "P34443", "WBGene00010038", "species_29438", "P91040", "WBGene00015697", "Q95Q95", "WBGene00002583", "Q68TI8", "WBGene00000911", "species_29420", "Q22743", "WBGene00006414", "G5EGB3", "WBGene00012497", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "Q9XXU9", "WBGene00006920", "Q22494", "WBGene00020507", "Q23680", "WBGene00006918", "P34462", "WBGene00010130", "Q9XW92", "WBGene00013025", "Q19626", "WBGene00006921", "Q9N5A0", "WBGene00004959", "Q95X44", "WBGene00006917", "P91303", "WBGene00006919", "C0HLB3", "WBGene00006911", "C0HLB4", "WBGene00006912", "Q95YD5", "WBGene00016258", "G5EEK9", "WBGene00006914", "G5EGP4", "WBGene00006915", "P30628", "WBGene00006768", "B2MZD0", "WBGene00006916", "Q20591", "WBGene00009882", "G5EDB8", "WBGene00006913", "species_29420", "G5EGB3", "WBGene00012497", "Q22743", "WBGene00006414", "species_29438", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "Q9XXU9", "WBGene00006920", "Q22494", "WBGene00020507", "Q23680", "WBGene00006918", "P34462", "WBGene00010130", "Q9XW92", "WBGene00013025", "Q19626", "WBGene00006921", "Q9N5A0", "WBGene00004959", "Q95X44", "WBGene00006917", "P91303", "WBGene00006919", "C0HLB3", "WBGene00006911", "C0HLB4", "WBGene00006912", "Q95YD5", "WBGene00016258", "G5EEK9", "WBGene00006914", "G5EGP4", "WBGene00006915", "P30628", "WBGene00006768", "B2MZD0", "WBGene00006916", "Q20591", "WBGene00009882", "G5EDB8", "WBGene00006913", "P91040", "WBGene00015697", "Q95Q95", "WBGene00002583", "Q68TI8", "WBGene00000911", "P34443", "WBGene00010038" ] }, "reaction_10572444": { "compartment": "compartment_17938", "id": "reaction_10572444", "reactome": "R-CEL-9640167", "name": "RRAGA,B exchanges GDP for GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10572437" ], "products": [ "species_29420", "species_10572441" ], "modifiers": [ [ "species_10572437", "catalyst" ] ], "additional_components": [ "Q19425", "WBGene00008774", "species_29468", "species_29420", "Q22743", "WBGene00006414", "G5EGB3", "WBGene00012497", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "Q9XXU9", "WBGene00006920", "Q22494", "WBGene00020507", "Q23680", "WBGene00006918", "P34462", "WBGene00010130", "Q9XW92", "WBGene00013025", "Q19626", "WBGene00006921", "Q9N5A0", "WBGene00004959", "Q95X44", "WBGene00006917", "P91303", "WBGene00006919", "C0HLB3", "WBGene00006911", "C0HLB4", "WBGene00006912", "Q95YD5", "WBGene00016258", "G5EEK9", "WBGene00006914", "G5EGP4", "WBGene00006915", "P30628", "WBGene00006768", "B2MZD0", "WBGene00006916", "Q20591", "WBGene00009882", "G5EDB8", "WBGene00006913", "Q19425", "WBGene00008774", "species_29468", "species_29420", "G5EGB3", "WBGene00012497", "Q22743", "WBGene00006414", "species_29438", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "Q9XXU9", "WBGene00006920", "Q22494", "WBGene00020507", "Q23680", "WBGene00006918", "P34462", "WBGene00010130", "Q9XW92", "WBGene00013025", "Q19626", "WBGene00006921", "Q9N5A0", "WBGene00004959", "Q95X44", "WBGene00006917", "P91303", "WBGene00006919", "C0HLB3", "WBGene00006911", "C0HLB4", "WBGene00006912", "Q95YD5", "WBGene00016258", "G5EEK9", "WBGene00006914", "G5EGP4", "WBGene00006915", "P30628", "WBGene00006768", "B2MZD0", "WBGene00006916", "Q20591", "WBGene00009882", "G5EDB8", "WBGene00006913", "Q19425", "WBGene00008774", "species_29468", "species_29420", "Q22743", "WBGene00006414", "G5EGB3", "WBGene00012497", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "Q9XXU9", "WBGene00006920", "Q22494", "WBGene00020507", "Q23680", "WBGene00006918", "P34462", "WBGene00010130", "Q9XW92", "WBGene00013025", "Q19626", "WBGene00006921", "Q9N5A0", "WBGene00004959", "Q95X44", "WBGene00006917", "P91303", "WBGene00006919", "C0HLB3", "WBGene00006911", "C0HLB4", "WBGene00006912", "Q95YD5", "WBGene00016258", "G5EEK9", "WBGene00006914", "G5EGP4", "WBGene00006915", "P30628", "WBGene00006768", "B2MZD0", "WBGene00006916", "Q20591", "WBGene00009882", "G5EDB8", "WBGene00006913" ] }, "reaction_10572542": { "compartment": "compartment_17938", "id": "reaction_10572542", "reactome": "R-CEL-9645598", "name": "RRAGC,D hydrolyzes GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10572426" ], "products": [ "species_10572430", "species_29372" ], "modifiers": [ [ "species_10572426", "catalyst" ], [ "species_10572540", "catalyst" ] ], "additional_components": [ "species_29420", "Q22743", "WBGene00006414", "G5EGB3", "WBGene00012497", "species_29438", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "Q9XXU9", "WBGene00006920", "Q22494", "WBGene00020507", "Q23680", "WBGene00006918", "P34462", "WBGene00010130", "Q9XW92", "WBGene00013025", "Q19626", "WBGene00006921", "Q9N5A0", "WBGene00004959", "Q95X44", "WBGene00006917", "P91303", "WBGene00006919", "C0HLB3", "WBGene00006911", "C0HLB4", "WBGene00006912", "Q95YD5", "WBGene00016258", "G5EEK9", "WBGene00006914", "G5EGP4", "WBGene00006915", "P30628", "WBGene00006768", "B2MZD0", "WBGene00006916", "Q20591", "WBGene00009882", "G5EDB8", "WBGene00006913", "species_29420", "Q22743", "WBGene00006414", "G5EGB3", "WBGene00012497", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "Q9XXU9", "WBGene00006920", "Q22494", "WBGene00020507", "Q23680", "WBGene00006918", "P34462", "WBGene00010130", "Q9XW92", "WBGene00013025", "Q19626", "WBGene00006921", "Q9N5A0", "WBGene00004959", "Q95X44", "WBGene00006917", "P91303", "WBGene00006919", "C0HLB3", "WBGene00006911", "C0HLB4", "WBGene00006912", "Q95YD5", "WBGene00016258", "G5EEK9", "WBGene00006914", "G5EGP4", "WBGene00006915", "P30628", "WBGene00006768", "B2MZD0", "WBGene00006916", "Q20591", "WBGene00009882", "G5EDB8", "WBGene00006913", "species_29420", "Q22743", "WBGene00006414", "G5EGB3", "WBGene00012497", "species_29438", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "Q9XXU9", "WBGene00006920", "Q22494", "WBGene00020507", "Q23680", "WBGene00006918", "P34462", "WBGene00010130", "Q9XW92", "WBGene00013025", "Q19626", "WBGene00006921", "Q9N5A0", "WBGene00004959", "Q95X44", "WBGene00006917", "P91303", "WBGene00006919", "C0HLB3", "WBGene00006911", "C0HLB4", "WBGene00006912", "Q95YD5", "WBGene00016258", "G5EEK9", "WBGene00006914", "G5EGP4", "WBGene00006915", "P30628", "WBGene00006768", "B2MZD0", "WBGene00006916", "Q20591", "WBGene00009882", "G5EDB8", "WBGene00006913", "S6FMZ4", "WBGene00017699", "H2L0I8", "WBGene00020208" ] }, "reaction_10572446": { "compartment": "compartment_17938", "id": "reaction_10572446", "reactome": "R-CEL-9640168", "name": "v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10572441" ], "products": [ "species_10572439", "species_10572435" ], "modifiers": [], "additional_components": [ "Q19425", "WBGene00008774", "species_29468", "species_29420", "G5EGB3", "WBGene00012497", "Q22743", "WBGene00006414", "species_29438", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "Q9XXU9", "WBGene00006920", "Q22494", "WBGene00020507", "Q23680", "WBGene00006918", "P34462", "WBGene00010130", "Q9XW92", "WBGene00013025", "Q19626", "WBGene00006921", "Q9N5A0", "WBGene00004959", "Q95X44", "WBGene00006917", "P91303", "WBGene00006919", "C0HLB3", "WBGene00006911", "C0HLB4", "WBGene00006912", "Q95YD5", "WBGene00016258", "G5EEK9", "WBGene00006914", "G5EGP4", "WBGene00006915", "P30628", "WBGene00006768", "B2MZD0", "WBGene00006916", "Q20591", "WBGene00009882", "G5EDB8", "WBGene00006913", "species_29420", "G5EGB3", "WBGene00012497", "Q22743", "WBGene00006414", "species_29438", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "Q9XXU9", "WBGene00006920", "Q22494", "WBGene00020507", "Q23680", "WBGene00006918", "P34462", "WBGene00010130", "Q9XW92", "WBGene00013025", "Q19626", "WBGene00006921", "Q9N5A0", "WBGene00004959", "Q95X44", "WBGene00006917", "P91303", "WBGene00006919", "C0HLB3", "WBGene00006911", "C0HLB4", "WBGene00006912", "Q95YD5", "WBGene00016258", "G5EEK9", "WBGene00006914", "G5EGP4", "WBGene00006915", "P30628", "WBGene00006768", "B2MZD0", "WBGene00006916", "Q20591", "WBGene00009882", "G5EDB8", "WBGene00006913", "Q19425", "WBGene00008774", "species_29468" ] }, "reaction_10557938": { "compartment": "compartment_7660", "id": "reaction_10557938", "reactome": "R-CEL-6782141", "name": "Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10557934", "species_10508627" ], "products": [ "species_10557936" ], "modifiers": [], "additional_components": [ "Q95Y97", "WBGene00019767", "Q23088", "WBGene00022812", "Q7JKC3", "WBGene00010406", "P34545", "WBGene00000366", "Q21302", "WBGene00006963", "H2KYV0", "WBGene00016115", "P52652", "WBGene00012000", "Q18963", "WBGene00008403", "Q21554", "WBGene00010890", "Q23457", "WBGene00004320", "Q17392", "WBGene00000839", "Q19826", "WBGene00017830", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "O02092", "WBGene00018391", "Q9GR61", "WBGene00021347", "Q9N3C9", "WBGene00021845", "Q93338", "WBGene00007971", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q86D18", "WBGene00010011", "Q10051", "WBGene00020423", "Q20716", "WBGene00009966", "Q9U1Q7", "WBGene00001258", "Q9U2S6", "WBGene00000889", "P52009", "WBGene00000877", "P52016", "WBGene00000884", "P91175", "WBGene00016837", "Q22139", "WBGene00011411", "G5EBZ1", "WBGene00008140", "Q93456", "WBGene00008665", "G5EBZ1", "WBGene00008140", "Q93456", "WBGene00008665", "Q95Y97", "WBGene00019767", "Q23088", "WBGene00022812", "Q7JKC3", "WBGene00010406", "P34545", "WBGene00000366", "Q21302", "WBGene00006963", "H2KYV0", "WBGene00016115", "P52652", "WBGene00012000", "Q18963", "WBGene00008403", "Q21554", "WBGene00010890", "Q23457", "WBGene00004320", "Q17392", "WBGene00000839", "Q19826", "WBGene00017830", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "O02092", "WBGene00018391", "Q9GR61", "WBGene00021347", "Q9N3C9", "WBGene00021845", "Q93338", "WBGene00007971", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q86D18", "WBGene00010011", "Q10051", "WBGene00020423", "Q20716", "WBGene00009966", "Q9U1Q7", "WBGene00001258", "Q9U2S6", "WBGene00000889", "P52009", "WBGene00000877", "P52016", "WBGene00000884", "P91175", "WBGene00016837", "Q22139", "WBGene00011411" ] }, "reaction_10573109": { "compartment": "compartment_7660", "id": "reaction_10573109", "reactome": "R-CEL-9684118", "name": "ERCC3-facilitated RNA Pol II backtracking in TC-NER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10557921" ], "products": [ "species_113550", "species_113582", "species_10557932" ], "modifiers": [ [ "species_10557921", "catalyst" ] ], "additional_components": [ "Q23088", "WBGene00022812", "Q7JKC3", "WBGene00010406", "P34545", "WBGene00000366", "Q21302", "WBGene00006963", "H2KYV0", "WBGene00016115", "P52652", "WBGene00012000", "Q10051", "WBGene00020423", "Q20716", "WBGene00009966", "Q9U1Q7", "WBGene00001258", "Q9U2S6", "WBGene00000889", "P52009", "WBGene00000877", "P52016", "WBGene00000884", "P91175", "WBGene00016837", "Q22139", "WBGene00011411", "Q18963", "WBGene00008403", "Q21554", "WBGene00010890", "Q23457", "WBGene00004320", "Q17392", "WBGene00000839", "Q19826", "WBGene00017830", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "O02092", "WBGene00018391", "Q9GR61", "WBGene00021347", "Q9N3C9", "WBGene00021845", "Q93338", "WBGene00007971", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q86D18", "WBGene00010011", "Q23088", "WBGene00022812", "Q7JKC3", "WBGene00010406", "P34545", "WBGene00000366", "Q21302", "WBGene00006963", "H2KYV0", "WBGene00016115", "P52652", "WBGene00012000", "Q18963", "WBGene00008403", "Q21554", "WBGene00010890", "Q23457", "WBGene00004320", "Q17392", "WBGene00000839", "Q19826", "WBGene00017830", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "O02092", "WBGene00018391", "Q9GR61", "WBGene00021347", "Q9N3C9", "WBGene00021845", "Q93338", "WBGene00007971", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q86D18", "WBGene00010011", "Q10051", "WBGene00020423", "Q20716", "WBGene00009966", "Q9U1Q7", "WBGene00001258", "Q9U2S6", "WBGene00000889", "P52009", "WBGene00000877", "P52016", "WBGene00000884", "P91175", "WBGene00016837", "Q22139", "WBGene00011411", "Q23088", "WBGene00022812", "Q7JKC3", "WBGene00010406", "P34545", "WBGene00000366", "Q21302", "WBGene00006963", "H2KYV0", "WBGene00016115", "P52652", "WBGene00012000", "Q10051", "WBGene00020423", "Q20716", "WBGene00009966", "Q9U1Q7", "WBGene00001258", "Q9U2S6", "WBGene00000889", "P52009", "WBGene00000877", "P52016", "WBGene00000884", "P91175", "WBGene00016837", "Q22139", "WBGene00011411", "Q18963", "WBGene00008403", "Q21554", "WBGene00010890", "Q23457", "WBGene00004320", "Q17392", "WBGene00000839", "Q19826", "WBGene00017830", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "O02092", "WBGene00018391", "Q9GR61", "WBGene00021347", "Q9N3C9", "WBGene00021845", "Q93338", "WBGene00007971", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q86D18", "WBGene00010011" ] }, "reaction_10557924": { "compartment": "compartment_7660", "id": "reaction_10557924", "reactome": "R-CEL-6782131", "name": "ERCC2-facilitated RNA Pol II backtracking in TC-NER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10557910" ], "products": [ "species_113550", "species_113582", "species_10557921" ], "modifiers": [ [ "species_10557910", "catalyst" ] ], "additional_components": [ "Q23088", "WBGene00022812", "Q7JKC3", "WBGene00010406", "P34545", "WBGene00000366", "Q18963", "WBGene00008403", "Q21554", "WBGene00010890", "Q23457", "WBGene00004320", "Q17392", "WBGene00000839", "Q19826", "WBGene00017830", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "O02092", "WBGene00018391", "Q9GR61", "WBGene00021347", "Q9N3C9", "WBGene00021845", "Q93338", "WBGene00007971", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q86D18", "WBGene00010011", "Q21302", "WBGene00006963", "H2KYV0", "WBGene00016115", "P52652", "WBGene00012000", "Q10051", "WBGene00020423", "Q20716", "WBGene00009966", "Q9U1Q7", "WBGene00001258", "Q9U2S6", "WBGene00000889", "P52009", "WBGene00000877", "P52016", "WBGene00000884", "P91175", "WBGene00016837", "Q22139", "WBGene00011411", "Q23088", "WBGene00022812", "Q7JKC3", "WBGene00010406", "P34545", "WBGene00000366", "Q21302", "WBGene00006963", "H2KYV0", "WBGene00016115", "P52652", "WBGene00012000", "Q10051", "WBGene00020423", "Q20716", "WBGene00009966", "Q9U1Q7", "WBGene00001258", "Q9U2S6", "WBGene00000889", "P52009", "WBGene00000877", "P52016", "WBGene00000884", "P91175", "WBGene00016837", "Q22139", "WBGene00011411", "Q18963", "WBGene00008403", "Q21554", "WBGene00010890", "Q23457", "WBGene00004320", "Q17392", "WBGene00000839", "Q19826", "WBGene00017830", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "O02092", "WBGene00018391", "Q9GR61", "WBGene00021347", "Q9N3C9", "WBGene00021845", "Q93338", "WBGene00007971", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q86D18", "WBGene00010011", "Q23088", "WBGene00022812", "Q7JKC3", "WBGene00010406", "P34545", "WBGene00000366", "Q18963", "WBGene00008403", "Q21554", "WBGene00010890", "Q23457", "WBGene00004320", "Q17392", "WBGene00000839", "Q19826", "WBGene00017830", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "O02092", "WBGene00018391", "Q9GR61", "WBGene00021347", "Q9N3C9", "WBGene00021845", "Q93338", "WBGene00007971", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q86D18", "WBGene00010011", "Q21302", "WBGene00006963", "H2KYV0", "WBGene00016115", "P52652", "WBGene00012000", "Q10051", "WBGene00020423", "Q20716", "WBGene00009966", "Q9U1Q7", "WBGene00001258", "Q9U2S6", "WBGene00000889", "P52009", "WBGene00000877", "P52016", "WBGene00000884", "P91175", "WBGene00016837", "Q22139", "WBGene00011411" ] }, "reaction_10557943": { "compartment": "compartment_7660", "id": "reaction_10557943", "reactome": "R-CEL-6782204", "name": "5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10557936" ], "products": [ "species_10557940" ], "modifiers": [ [ "species_10557936", "catalyst" ] ], "additional_components": [ "G5EBZ1", "WBGene00008140", "Q93456", "WBGene00008665", "Q95Y97", "WBGene00019767", "Q23088", "WBGene00022812", "Q7JKC3", "WBGene00010406", "P34545", "WBGene00000366", "Q21302", "WBGene00006963", "H2KYV0", "WBGene00016115", "P52652", "WBGene00012000", "Q18963", "WBGene00008403", "Q21554", "WBGene00010890", "Q23457", "WBGene00004320", "Q17392", "WBGene00000839", "Q19826", "WBGene00017830", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "O02092", "WBGene00018391", "Q9GR61", "WBGene00021347", "Q9N3C9", "WBGene00021845", "Q93338", "WBGene00007971", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q86D18", "WBGene00010011", "Q10051", "WBGene00020423", "Q20716", "WBGene00009966", "Q9U1Q7", "WBGene00001258", "Q9U2S6", "WBGene00000889", "P52009", "WBGene00000877", "P52016", "WBGene00000884", "P91175", "WBGene00016837", "Q22139", "WBGene00011411", "Q18963", "WBGene00008403", "Q21554", "WBGene00010890", "Q23457", "WBGene00004320", "Q17392", "WBGene00000839", "P34545", "WBGene00000366", "Q23088", "WBGene00022812", "Q7JKC3", "WBGene00010406", "Q21302", "WBGene00006963", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q10051", "WBGene00020423", "Q20716", "WBGene00009966", "Q9U1Q7", "WBGene00001258", "Q9U2S6", "WBGene00000889", "P52009", "WBGene00000877", "P52016", "WBGene00000884", "P91175", "WBGene00016837", "Q22139", "WBGene00011411", "Q95Y97", "WBGene00019767", "Q19826", "WBGene00017830", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "O02092", "WBGene00018391", "Q9GR61", "WBGene00021347", "Q9N3C9", "WBGene00021845", "Q93338", "WBGene00007971", "G5EBZ1", "WBGene00008140", "Q93456", "WBGene00008665", "H2KYV0", "WBGene00016115", "P52652", "WBGene00012000", "Q86D18", "WBGene00010011", "G5EBZ1", "WBGene00008140", "Q93456", "WBGene00008665", "Q95Y97", "WBGene00019767", "Q23088", "WBGene00022812", "Q7JKC3", "WBGene00010406", "P34545", "WBGene00000366", "Q21302", "WBGene00006963", "H2KYV0", "WBGene00016115", "P52652", "WBGene00012000", "Q18963", "WBGene00008403", "Q21554", "WBGene00010890", "Q23457", "WBGene00004320", "Q17392", "WBGene00000839", "Q19826", "WBGene00017830", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "O02092", "WBGene00018391", "Q9GR61", "WBGene00021347", "Q9N3C9", "WBGene00021845", "Q93338", "WBGene00007971", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q86D18", "WBGene00010011", "Q10051", "WBGene00020423", "Q20716", "WBGene00009966", "Q9U1Q7", "WBGene00001258", "Q9U2S6", "WBGene00000889", "P52009", "WBGene00000877", "P52016", "WBGene00000884", "P91175", "WBGene00016837", "Q22139", "WBGene00011411" ] }, "reaction_10557958": { "compartment": "compartment_7660", "id": "reaction_10557958", "reactome": "R-CEL-6782211", "name": "DNA polymerases delta, epsilon or kappa bind the TC-NER site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10557940", "species_10557954", "species_10502642", "species_10557952" ], "products": [ "species_10557956" ], "modifiers": [], "additional_components": [ "Q18963", "WBGene00008403", "Q21554", "WBGene00010890", "Q23457", "WBGene00004320", "Q17392", "WBGene00000839", "P34545", "WBGene00000366", "Q23088", "WBGene00022812", "Q7JKC3", "WBGene00010406", "Q21302", "WBGene00006963", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q10051", "WBGene00020423", "Q20716", "WBGene00009966", "Q9U1Q7", "WBGene00001258", "Q9U2S6", "WBGene00000889", "P52009", "WBGene00000877", "P52016", "WBGene00000884", "P91175", "WBGene00016837", "Q22139", "WBGene00011411", "Q95Y97", "WBGene00019767", "Q19826", "WBGene00017830", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "O02092", "WBGene00018391", "Q9GR61", "WBGene00021347", "Q9N3C9", "WBGene00021845", "Q93338", "WBGene00007971", "G5EBZ1", "WBGene00008140", "Q93456", "WBGene00008665", "H2KYV0", "WBGene00016115", "P52652", "WBGene00012000", "Q86D18", "WBGene00010011", "O02115", "WBGene00003955", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "P90829", "WBGene00008645", "Q19366", "WBGene00008722", "Q21730", "WBGene00011016", "P34409", "WBGene00017696", "Q95Y97", "WBGene00019767", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "P90829", "WBGene00008645", "Q19366", "WBGene00008722", "Q21730", "WBGene00011016", "O02115", "WBGene00003955", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "P34409", "WBGene00017696", "Q18963", "WBGene00008403", "Q21554", "WBGene00010890", "Q23457", "WBGene00004320", "Q17392", "WBGene00000839", "P34545", "WBGene00000366", "Q23088", "WBGene00022812", "Q7JKC3", "WBGene00010406", "Q21302", "WBGene00006963", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q10051", "WBGene00020423", "Q20716", "WBGene00009966", "Q9U1Q7", "WBGene00001258", "Q9U2S6", "WBGene00000889", "P52009", "WBGene00000877", "P52016", "WBGene00000884", "P91175", "WBGene00016837", "Q22139", "WBGene00011411", "Q19826", "WBGene00017830", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "O02092", "WBGene00018391", "Q9GR61", "WBGene00021347", "Q9N3C9", "WBGene00021845", "Q93338", "WBGene00007971", "G5EBZ1", "WBGene00008140", "Q93456", "WBGene00008665", "H2KYV0", "WBGene00016115", "P52652", "WBGene00012000", "Q86D18", "WBGene00010011" ] }, "reaction_10553056": { "compartment": "compartment_70101", "id": "reaction_10553056", "reactome": "R-CEL-5618105", "name": "FKBP5 binds HSP90:ATP:STIP1:HSP70:nascent protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10553038", "species_10552844" ], "products": [ "species_10553046" ], "modifiers": [], "additional_components": [ "P09446", "WBGene00002005", "G5ECU5", "WBGene00009691", "O45246", "WBGene00002026", "G5EC99", "WBGene00009691", "species_113582", "O16259", "WBGene00019983", "Q18688", "WBGene00000915", "species_29358", "WBGene00001431", "O45418", "WBGene00001431", "P09446", "WBGene00002005", "G5ECU5", "WBGene00009691", "O45246", "WBGene00002026", "G5EC99", "WBGene00009691", "species_113582", "O16259", "WBGene00019983", "Q18688", "WBGene00000915", "species_29358" ] }, "reaction_10573120": { "compartment": "compartment_70101", "id": "reaction_10573120", "reactome": "R-CEL-9690534", "name": "SH binds NR3C1 (in HSP90:ATP:FKBP4:PTGES3:NR3C1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10552862", "species_5618094" ], "products": [ "species_10552864" ], "modifiers": [ [ "species_10573086", "catalyst" ] ], "additional_components": [ "O45418", "WBGene00001431", "Q18688", "WBGene00000915", "species_29358", "Q23280", "WBGene00022599", "species_193057", "species_469662", "CHEBI:16973", "species_193977", "CHEBI:27584", "CHEBI:17026", "species_193057", "species_469662", "CHEBI:16973", "species_193977", "CHEBI:27584", "CHEBI:17026", "O45418", "WBGene00001431", "Q18688", "WBGene00000915", "species_29358", "Q23280", "WBGene00022599", "O45418", "WBGene00001431", "Q18688", "WBGene00000915", "species_29358", "Q23280", "WBGene00022599" ] }, "reaction_10573088": { "compartment": "compartment_70101", "id": "reaction_10573088", "reactome": "R-CEL-9678925", "name": "NR3C1 binds NR3C1 agonists", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10552862", "species_9678859" ], "products": [ "species_10573086" ], "modifiers": [], "additional_components": [ "O45418", "WBGene00001431", "Q18688", "WBGene00000915", "species_29358", "Q23280", "WBGene00022599", "O45418", "WBGene00001431", "Q18688", "WBGene00000915", "species_29358", "Q23280", "WBGene00022599" ] }, "reaction_10547715": { "compartment": "compartment_70101", "id": "reaction_10547715", "reactome": "R-CEL-3371590", "name": "HSP70 binds to HSP40:nascent protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10547711", "species_10547713" ], "products": [ "species_10547586" ], "modifiers": [], "additional_components": [ "O45502", "WBGene00001030", "O16303", "WBGene00001037", "P09446", "WBGene00002005", "G5ECU5", "WBGene00009691", "O45246", "WBGene00002026", "G5EC99", "WBGene00009691", "species_29358", "P09446", "WBGene00002005", "G5ECU5", "WBGene00009691", "O45246", "WBGene00002026", "G5EC99", "WBGene00009691", "O45502", "WBGene00001030", "O16303", "WBGene00001037", "species_29358" ] }, "reaction_10553058": { "compartment": "compartment_70101", "id": "reaction_10553058", "reactome": "R-CEL-5618107", "name": "ATP binding to HSP90 triggers conformation change", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10547658", "species_113592" ], "products": [ "species_10553038" ], "modifiers": [], "additional_components": [ "Q18688", "WBGene00000915", "P09446", "WBGene00002005", "G5ECU5", "WBGene00009691", "O45246", "WBGene00002026", "G5EC99", "WBGene00009691", "species_113582", "O16259", "WBGene00019983", "P09446", "WBGene00002005", "G5ECU5", "WBGene00009691", "O45246", "WBGene00002026", "G5EC99", "WBGene00009691", "species_113582", "O16259", "WBGene00019983", "Q18688", "WBGene00000915", "species_29358" ] }, "reaction_10553060": { "compartment": "compartment_70101", "id": "reaction_10553060", "reactome": "R-CEL-5618110", "name": "p23 (PTGES3) binds HSP90:ATP:FKBP4:nascent protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10517708", "species_10553040" ], "products": [ "species_10547646", "species_10552852", "species_10547713" ], "modifiers": [], "additional_components": [ "WBGene00022599", "O45418", "WBGene00001431", "P09446", "WBGene00002005", "G5ECU5", "WBGene00009691", "O45246", "WBGene00002026", "G5EC99", "WBGene00009691", "species_113582", "O16259", "WBGene00019983", "Q18688", "WBGene00000915", "species_29358", "WBGene00019983", "O45418", "WBGene00001431", "Q23280", "WBGene00022599", "Q18688", "WBGene00000915", "species_29358", "P09446", "WBGene00002005", "G5ECU5", "WBGene00009691", "O45246", "WBGene00002026", "G5EC99", "WBGene00009691", "species_29358" ] }, "reaction_10547591": { "compartment": "compartment_70101", "id": "reaction_10547591", "reactome": "R-CEL-3371422", "name": "ATP hydrolysis by HSP70", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10547586" ], "products": [ "species_29372", "species_10547588" ], "modifiers": [ [ "species_10547586", "catalyst" ], [ "species_10547584", "catalyst" ] ], "additional_components": [ "P09446", "WBGene00002005", "G5ECU5", "WBGene00009691", "O45246", "WBGene00002026", "G5EC99", "WBGene00009691", "O45502", "WBGene00001030", "O16303", "WBGene00001037", "species_29358", "P09446", "WBGene00002005", "G5ECU5", "WBGene00009691", "O45246", "WBGene00002026", "G5EC99", "WBGene00009691", "O45502", "WBGene00001030", "O16303", "WBGene00001037", "species_113582", "P09446", "WBGene00002005", "G5ECU5", "WBGene00009691", "O45246", "WBGene00002026", "G5EC99", "WBGene00009691", "O45502", "WBGene00001030", "O16303", "WBGene00001037", "species_29358", "O45502", "WBGene00001030", "O16303", "WBGene00001037" ] }, "reaction_10553035": { "compartment": "compartment_70101", "id": "reaction_10553035", "reactome": "R-CEL-5618080", "name": "HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10552858", "species_10552864" ], "products": [ "species_10552874", "species_10552868" ], "modifiers": [ [ "species_10553033", "catalyst" ] ], "additional_components": [ "O45418", "WBGene00001431", "Q18688", "WBGene00000915", "species_29358", "Q23280", "WBGene00022599", "species_193057", "species_469662", "CHEBI:16973", "species_193977", "CHEBI:27584", "CHEBI:17026", "O45418", "WBGene00001431", "Q18688", "WBGene00000915", "species_29358", "Q23280", "WBGene00022599", "species_469662", "species_193977", "CHEBI:17026", "CHEBI:27584", "CHEBI:16973", "species_193057", "O45418", "WBGene00001431", "Q23280", "WBGene00022599", "Q18688", "WBGene00000915", "species_29358", "O45418", "WBGene00001431", "Q23280", "WBGene00022599", "Q18688", "WBGene00000915", "species_29358", "Q19020", "WBGene00000962", "O45087", "WBGene00015927", "Q65XS9", "WBGene00043067", "A0AAC1", "WBGene00012424", "Q7YTJ8", "WBGene00012425", "Q21557", "WBGene00010888", "Q22799", "WBGene00001005", "G5ED34", "WBGene00001007", "species_29420", "species_29438", "Q9NA98", "WBGene00013168", "P34685", "WBGene00000292", "P34686", "WBGene00000293", "Q18194", "WBGene00016124", "Q9N4I1", "WBGene00022118", "Q9N3F1", "WBGene00021827", "Q9GYR2", "WBGene00016793", "Q09248", "WBGene00001018", "E2JKZ0", "WBGene00001017" ] }, "reaction_10547660": { "compartment": "compartment_70101", "id": "reaction_10547660", "reactome": "R-CEL-3371503", "name": "STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10547646", "species_10547588", "species_10547652" ], "products": [ "species_10547658", "species_10547584" ], "modifiers": [], "additional_components": [ "WBGene00019983", "P09446", "WBGene00002005", "G5ECU5", "WBGene00009691", "O45246", "WBGene00002026", "G5EC99", "WBGene00009691", "O45502", "WBGene00001030", "O16303", "WBGene00001037", "species_113582", "Q18688", "WBGene00000915", "Q18688", "WBGene00000915", "P09446", "WBGene00002005", "G5ECU5", "WBGene00009691", "O45246", "WBGene00002026", "G5EC99", "WBGene00009691", "species_113582", "O16259", "WBGene00019983", "O45502", "WBGene00001030", "O16303", "WBGene00001037" ] }, "reaction_10573294": { "compartment": "compartment_70101", "id": "reaction_10573294", "reactome": "R-CEL-9705925", "name": "Androgens binds AR (in the HSP90 chaperone complex)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8979218", "species_10573288" ], "products": [ "species_10573292" ], "modifiers": [], "additional_components": [ "species_193057", "species_193079", "species_469662", "CHEBI:29117", "O45418", "WBGene00001431", "Q18688", "WBGene00000915", "species_29358", "Q23280", "WBGene00022599", "O45418", "WBGene00001431", "Q18688", "WBGene00000915", "species_29358", "species_193057", "species_193079", "species_469662", "CHEBI:29117", "Q23280", "WBGene00022599" ] }, "reaction_10553042": { "compartment": "compartment_70101", "id": "reaction_10553042", "reactome": "R-CEL-5618085", "name": "FKBP4 binds HSP90:ATP:STIP1:HSP70:nascent protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10553038", "species_10552850" ], "products": [ "species_10553040" ], "modifiers": [], "additional_components": [ "P09446", "WBGene00002005", "G5ECU5", "WBGene00009691", "O45246", "WBGene00002026", "G5EC99", "WBGene00009691", "species_113582", "O16259", "WBGene00019983", "Q18688", "WBGene00000915", "species_29358", "WBGene00001431", "O45418", "WBGene00001431", "P09446", "WBGene00002005", "G5ECU5", "WBGene00009691", "O45246", "WBGene00002026", "G5EC99", "WBGene00009691", "species_113582", "O16259", "WBGene00019983", "Q18688", "WBGene00000915", "species_29358" ] }, "reaction_10552854": { "compartment": "compartment_70101", "id": "reaction_10552854", "reactome": "R-CEL-5618073", "name": "FKBP4 replaces FKBP5 within HSP90:ATP:FKBP5:unfolded protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10552850", "species_10552848" ], "products": [ "species_10552844", "species_10552852" ], "modifiers": [ [ "species_5618094", "catalyst" ] ], "additional_components": [ "WBGene00001431", "Q23280", "WBGene00022599", "O45418", "WBGene00001431", "Q18688", "WBGene00000915", "species_29358", "WBGene00001431", "O45418", "WBGene00001431", "Q23280", "WBGene00022599", "Q18688", "WBGene00000915", "species_29358", "species_193057", "species_469662", "CHEBI:16973", "species_193977", "CHEBI:27584", "CHEBI:17026" ] }, "reaction_10553048": { "compartment": "compartment_70101", "id": "reaction_10553048", "reactome": "R-CEL-5618098", "name": "p23 (PTGES3) binds HSP90:ATP:FKBP5:nascent protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10517708", "species_10553046" ], "products": [ "species_10547646", "species_10547713", "species_10552848" ], "modifiers": [], "additional_components": [ "WBGene00022599", "O45418", "WBGene00001431", "P09446", "WBGene00002005", "G5ECU5", "WBGene00009691", "O45246", "WBGene00002026", "G5EC99", "WBGene00009691", "species_113582", "O16259", "WBGene00019983", "Q18688", "WBGene00000915", "species_29358", "WBGene00019983", "P09446", "WBGene00002005", "G5ECU5", "WBGene00009691", "O45246", "WBGene00002026", "G5EC99", "WBGene00009691", "species_29358", "Q23280", "WBGene00022599", "O45418", "WBGene00001431", "Q18688", "WBGene00000915", "species_29358" ] }, "reaction_10553054": { "compartment": "compartment_70101", "id": "reaction_10553054", "reactome": "R-CEL-5618099", "name": "SH binds SHR within the HSP90 chaperone complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10553052", "species_5618094" ], "products": [ "species_10552858" ], "modifiers": [], "additional_components": [ "O45418", "WBGene00001431", "Q18688", "WBGene00000915", "species_29358", "Q23280", "WBGene00022599", "species_193057", "species_469662", "CHEBI:16973", "species_193977", "CHEBI:27584", "CHEBI:17026", "O45418", "WBGene00001431", "Q18688", "WBGene00000915", "species_29358", "Q23280", "WBGene00022599" ] }, "reaction_10532184": { "compartment": "compartment_70101", "id": "reaction_10532184", "reactome": "R-CEL-1234161", "name": "HIF-alpha translocates from cytosol to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10532172" ], "products": [ "species_10532178" ], "modifiers": [], "additional_components": [ "WBGene00001851", "WBGene00001851" ] }, "reaction_10532232": { "compartment": "compartment_7660", "id": "reaction_10532232", "reactome": "R-CEL-1234167", "name": "Formation of HIF:CBP:p300 complex at promoters", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10532221", "species_29428", "species_10532228", "species_10532226" ], "products": [ "species_10532230" ], "modifiers": [], "additional_components": [ "G5EGD2", "WBGene00001851", "O02219", "WBGene00000095", "WBGene00000366", "WBGene00000366", "P34545", "WBGene00000366", "G5EGD2", "WBGene00001851", "O02219", "WBGene00000095" ] }, "reaction_10532250": { "compartment": "compartment_7660", "id": "reaction_10532250", "reactome": "R-CEL-1234171", "name": "HIF-alpha binds ARNT (HIF1-beta) forming HIF-alpha:ARNT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10532219", "species_10532178" ], "products": [ "species_10532221" ], "modifiers": [], "additional_components": [ "WBGene00000095", "WBGene00001851", "G5EGD2", "WBGene00001851", "O02219", "WBGene00000095" ] }, "reaction_10518832": { "compartment": "compartment_984", "id": "reaction_10518832", "reactome": "R-CEL-374919", "name": "Noradrenaline clearance from the synaptic cleft", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_374935" ], "products": [ "species_209789" ], "modifiers": [ [ "species_10518786", "catalyst" ] ], "additional_components": [ "WBGene00003987" ] }, "reaction_10572361": { "compartment": "compartment_876", "id": "reaction_10572361", "reactome": "R-CEL-9634834", "name": "ACHEIs bind ACHE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10518366", "species_9634838" ], "products": [ "species_10518393" ], "modifiers": [], "additional_components": [ "Q23268", "WBGene00013873", "Q04457", "WBGene00001578", "H9G2Y9", "WBGene00013874", "A0A1C3NSL8", "WBGene00017478", "Q4LDP0", "WBGene00020891", "Q21266", "WBGene00019477", "O01302", "WBGene00011362", "G5EDJ7", "WBGene00013875", "Q9XW75", "WBGene00013540", "Q22008", "WBGene00020125", "P92016", "WBGene00011364", "H2L0K7", "WBGene00020330", "Q23268", "WBGene00013873", "Q04457", "WBGene00001578", "H9G2Y9", "WBGene00013874", "A0A1C3NSL8", "WBGene00017478", "Q4LDP0", "WBGene00020891", "Q21266", "WBGene00019477", "O01302", "WBGene00011362", "G5EDJ7", "WBGene00013875", "Q9XW75", "WBGene00013540", "Q22008", "WBGene00020125", "P92016", "WBGene00011364", "H2L0K7", "WBGene00020330" ] }, "reaction_10567745": { "compartment": "compartment_20699", "id": "reaction_10567745", "reactome": "R-CEL-8877813", "name": "DENND5A,B exchange GTP for GDP on RAB39", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10567729" ], "products": [ "species_29420", "species_10567735", "species_10567253" ], "modifiers": [ [ "species_10567740", "catalyst" ] ], "additional_components": [ "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "Q18969", "WBGene00004286", "species_29420", "Q18969", "WBGene00004286", "species_29438", "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "WBGene00016889" ] }, "reaction_10567680": { "compartment": "compartment_13946", "id": "reaction_10567680", "reactome": "R-CEL-8877475", "name": "TRAPPC complexes exchange GTP for GDP on RAB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10567646", "species_29438" ], "products": [ "species_29420", "species_10567656", "species_10567253" ], "modifiers": [ [ "species_10567677", "catalyst" ] ], "additional_components": [ "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "Q9UAQ6", "WBGene00004266", "species_29420", "Q9UAQ6", "WBGene00004266", "species_29438", "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "Q9NA81", "WBGene00013259", "B1GRL5", "WBGene00077643", "Q93330", "WBGene00007956", "B1V899", "WBGene00022138", "Q9XU81", "WBGene00010699", "O02173", "WBGene00021046", "Q5WRR4", "WBGene00016614", "G4SNB8", "WBGene00044604", "Q95QQ2", "WBGene00016964", "P34605", "WBGene00014222", "Q9BI63", "WBGene00018512", "Q20100", "WBGene00018088" ] }, "reaction_10567296": { "compartment": "compartment_171062", "id": "reaction_10567296", "reactome": "R-CEL-8875320", "name": "RAB5 GEFs exchange GTP for GDP on RAB5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10567270" ], "products": [ "species_10567278", "species_29420", "species_10567253" ], "modifiers": [ [ "species_10567293", "catalyst" ] ], "additional_components": [ "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "P91857", "WBGene00004268", "species_29420", "P91857", "WBGene00004268", "species_29438", "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "G5ECF0", "WBGene00008183", "A0A486WY48", "WBGene00012644", "Q9GYH7", "WBGene00004377" ] }, "reaction_10567266": { "compartment": "compartment_216813", "id": "reaction_10567266", "reactome": "R-CEL-8875318", "name": "RAB3 GEFs exchange GTP for GDP on RAB3A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10567255" ], "products": [ "species_29420", "species_10567259", "species_10567253" ], "modifiers": [ [ "species_10567263", "catalyst" ] ], "additional_components": [ "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "Q94986", "WBGene00004267", "species_29420", "Q94986", "WBGene00004267", "species_29438", "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "O02626", "WBGene00000086", "Q20759", "WBGene00010045" ] }, "reaction_10567429": { "compartment": "compartment_263163", "id": "reaction_10567429", "reactome": "R-CEL-8876190", "name": "RAB8 GEFs exchange GTP for GDP on RAB8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10567407", "species_29438" ], "products": [ "species_29420", "species_10567419", "species_10567253" ], "modifiers": [ [ "species_10567426", "catalyst" ] ], "additional_components": [ "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "G5EFC1", "WBGene00004272", "Q21137", "WBGene00019317", "species_29420", "G5EFC1", "WBGene00004272", "Q21137", "WBGene00019317", "species_29438", "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "Q20759", "WBGene00010045" ] }, "reaction_10567401": { "compartment": "compartment_437051", "id": "reaction_10567401", "reactome": "R-CEL-8876188", "name": "DENND4s exchange GTP for GDP on RAB10", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10567385" ], "products": [ "species_10567389", "species_29420", "species_10567253" ], "modifiers": [ [ "species_10567394", "catalyst" ] ], "additional_components": [ "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "Q94148", "WBGene00004273", "species_29420", "Q94148", "WBGene00004273", "species_29438", "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "WBGene00018681" ] }, "reaction_10567468": { "compartment": "compartment_70101", "id": "reaction_10567468", "reactome": "R-CEL-8876446", "name": "p-ULK1 phosphorylates DENND3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10567461" ], "products": [ "species_29370", "species_10567465" ], "modifiers": [ [ "species_10554852", "catalyst" ] ], "additional_components": [ "WBGene00018681", "WBGene00018681", "WBGene00006786" ] }, "reaction_10568111": { "compartment": "compartment_70101", "id": "reaction_10568111", "reactome": "R-CEL-8933446", "name": "Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10567690", "species_113592" ], "products": [ "species_10568106", "species_29370" ], "modifiers": [ [ "species_10513848", "catalyst" ] ], "additional_components": [ "WBGene00004375", "WBGene00004375", "Q9XTG7", "WBGene00000103", "G4S4W1", "WBGene00016980", "Q17941", "WBGene00000102" ] }, "reaction_10567695": { "compartment": "compartment_262783", "id": "reaction_10567695", "reactome": "R-CEL-8877612", "name": "DENND1s exchange GTP for GDP on RAB35", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10567684" ], "products": [ "species_29420", "species_10567688", "species_10567253" ], "modifiers": [ [ "species_10567690", "catalyst" ] ], "additional_components": [ "species_29420", "Q9U2C3", "WBGene00004284", "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "Q9U2C3", "WBGene00004284", "species_29438", "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "WBGene00004375" ] }, "reaction_10567569": { "compartment": "compartment_171062", "id": "reaction_10567569", "reactome": "R-CEL-8876837", "name": "RAB21 GEFs exchange GTP for GDP on RAB21", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10567558" ], "products": [ "species_29420", "species_10567562", "species_10567253" ], "modifiers": [ [ "species_10567564", "catalyst" ] ], "additional_components": [ "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "Q22045", "WBGene00004279", "species_29420", "Q22045", "WBGene00004279", "species_29438", "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "WBGene00003477" ] }, "reaction_10567536": { "compartment": "compartment_70101", "id": "reaction_10567536", "reactome": "R-CEL-8876616", "name": "DENND6A,B exchange GTP for GDP on RAB14", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10567520" ], "products": [ "species_29420", "species_10567524", "species_10567253" ], "modifiers": [ [ "species_10567533", "catalyst" ] ], "additional_components": [ "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "Q93874", "WBGene00004276", "species_29420", "Q93874", "WBGene00004276", "species_29438", "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "O45074", "WBGene00018777" ] }, "reaction_10567638": { "compartment": "compartment_17938", "id": "reaction_10567638", "reactome": "R-CEL-8877451", "name": "MON1:CCZ1 exchanges GTP for GDP on RAB7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10567615", "species_29438" ], "products": [ "species_29420", "species_10567621", "species_10567253" ], "modifiers": [ [ "species_10567635", "catalyst" ] ], "additional_components": [ "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "species_29420", "Q23146", "WBGene00004271", "Q23146", "WBGene00004271", "species_29438", "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "Q9XVL8", "WBGene00010283", "Q9BI89", "WBGene00018321" ] }, "reaction_10567611": { "compartment": "compartment_5668575", "id": "reaction_10567611", "reactome": "R-CEL-8877308", "name": "MADD exchanges GTP for GDP on RAB27", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10567598", "species_29438" ], "products": [ "species_29420", "species_10567608", "species_10567253" ], "modifiers": [ [ "species_10553865", "catalyst" ] ], "additional_components": [ "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "G5EBS5", "WBGene00000089", "species_29420", "G5EBS5", "WBGene00000089", "species_29438", "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "WBGene00000086" ] }, "reaction_10567485": { "compartment": "compartment_262783", "id": "reaction_10567485", "reactome": "R-CEL-8876454", "name": "DENND3 exchanges GTP for GDP on RAB12", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10567472" ], "products": [ "species_29420", "species_10567480", "species_10567253" ], "modifiers": [ [ "species_10567482", "catalyst" ] ], "additional_components": [ "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "Q21137", "WBGene00019317", "G5EFC1", "WBGene00004272", "species_29420", "G5EFC1", "WBGene00004272", "Q21137", "WBGene00019317", "species_29438", "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "U4PBM1", "WBGene00018681" ] }, "reaction_10567516": { "compartment": "compartment_204883", "id": "reaction_10567516", "reactome": "R-CEL-8876615", "name": "RAB13 GEFs exchange GTP for GDP on RAB13", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10567503", "species_29438" ], "products": [ "species_29420", "species_10567511", "species_10567253" ], "modifiers": [ [ "species_10567513", "catalyst" ] ], "additional_components": [ "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "species_29420", "G5EFC1", "WBGene00004272", "Q21137", "WBGene00019317", "G5EFC1", "WBGene00004272", "Q21137", "WBGene00019317", "species_29438", "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051" ] }, "reaction_10567454": { "compartment": "compartment_263163", "id": "reaction_10567454", "reactome": "R-CEL-8876193", "name": "RIC1-RGP1 exchanges GTP for GDP on RAB6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10567435" ], "products": [ "species_29420", "species_10567451", "species_10567253" ], "modifiers": [ [ "species_10564567", "catalyst" ] ], "additional_components": [ "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "Q22782", "WBGene00004270", "P34213", "WBGene00004269", "species_29420", "P34213", "WBGene00004269", "Q22782", "WBGene00004270", "species_29438", "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "Q7YWW8", "WBGene00010815", "Q09417", "WBGene00011071" ] }, "reaction_10567774": { "compartment": "compartment_12045", "id": "reaction_10567774", "reactome": "R-CEL-8877998", "name": "RAB3GAP1:RAB3GAP2 exchanges GTP for GDP on RAB18", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10567761" ], "products": [ "species_29420", "species_10567253", "species_10567765" ], "modifiers": [ [ "species_10567771", "catalyst" ] ], "additional_components": [ "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "species_29420", "Q8MXS1", "WBGene00004277", "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "Q8MXS1", "WBGene00004277", "species_29438", "Q93538", "WBGene00004317", "Q22670", "WBGene00004318" ] }, "reaction_10518562": { "compartment": "compartment_876", "id": "reaction_10518562", "reactome": "R-CEL-373741", "name": "SDK2 homophillic interaction", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10518558" ], "products": [ "species_10518560" ], "modifiers": [], "additional_components": [ "Q19663", "WBGene00017657", "Q9N3X8", "WBGene00004371", "Q19663", "WBGene00017657", "Q9N3X8", "WBGene00004371" ] }, "reaction_10518572": { "compartment": "compartment_876", "id": "reaction_10518572", "reactome": "R-CEL-373745", "name": "SDK1 homophillic interaction", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10518568" ], "products": [ "species_10518570" ], "modifiers": [], "additional_components": [ "Q19663", "WBGene00017657", "Q9N3X8", "WBGene00004371", "Q19663", "WBGene00017657", "Q9N3X8", "WBGene00004371" ] }, "reaction_10524053": { "compartment": "compartment_70101", "id": "reaction_10524053", "reactome": "R-CEL-432909", "name": "Interaction of Plectin with Integrin beta 4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10517311", "species_10514921" ], "products": [ "species_10524051" ], "modifiers": [], "additional_components": [ "Q03600", "WBGene00002081", "Q27874", "WBGene00003930", "WBGene00006876", "A0A1N7SYP3", "WBGene00006876", "Q03600", "WBGene00002081", "Q27874", "WBGene00003930" ] }, "reaction_10524069": { "compartment": "compartment_984", "id": "reaction_10524069", "reactome": "R-CEL-432956", "name": "BP230 is recruited to the hemidesmosome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10524061", "species_10524065" ], "products": [ "species_10524067" ], "modifiers": [], "additional_components": [ "A0A1N7SYP3", "WBGene00006876", "Q03600", "WBGene00002081", "Q27874", "WBGene00003930", "O44565", "WBGene00002247", "Q18823", "WBGene00016913", "Q19981", "WBGene00006432", "G5EG68", "WBGene00018304", "Q06561", "WBGene00006787", "G5ECE3", "WBGene00002248", "Q21313", "WBGene00001328", "A0A1N7SYP3", "WBGene00006876", "Q03600", "WBGene00002081", "Q27874", "WBGene00003930", "O44565", "WBGene00002247", "Q18823", "WBGene00016913", "Q19981", "WBGene00006432", "G5EG68", "WBGene00018304", "Q06561", "WBGene00006787", "G5ECE3", "WBGene00002248", "Q21313", "WBGene00001328" ] }, "reaction_10525053": { "compartment": "compartment_984", "id": "reaction_10525053", "reactome": "R-CEL-446089", "name": "BP180 interacts extracellularly with Laminin 332", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10525051", "species_10517354" ], "products": [ "species_10524061" ], "modifiers": [], "additional_components": [ "A0A1N7SYP3", "WBGene00006876", "Q03600", "WBGene00002081", "Q27874", "WBGene00003930", "O44565", "WBGene00002247", "Q18823", "WBGene00016913", "Q19981", "WBGene00006432", "G5EG68", "WBGene00018304", "Q06561", "WBGene00006787", "G5ECE3", "WBGene00002248", "Q21313", "WBGene00001328", "A0A1N7SYP3", "WBGene00006876", "Q03600", "WBGene00002081", "Q27874", "WBGene00003930", "O44565", "WBGene00002247", "Q18823", "WBGene00016913", "Q19981", "WBGene00006432", "G5EG68", "WBGene00018304", "Q06561", "WBGene00006787", "G5ECE3", "WBGene00002248", "Q21313", "WBGene00001328" ] }, "reaction_10525220": { "compartment": "compartment_70101", "id": "reaction_10525220", "reactome": "R-CEL-446391", "name": "Formation of the PINCH-ILK-parvin complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10525214", "species_10524045", "species_10525212" ], "products": [ "species_10525218" ], "modifiers": [], "additional_components": [ "WBGene00003931", "P50464", "WBGene00006826", "Q19157", "WBGene00004030", "Q9TZC4", "WBGene00003931" ] }, "reaction_10523749": { "compartment": "compartment_70101", "id": "reaction_10523749", "reactome": "R-CEL-430341", "name": "Mig-2 recruits Migfilin to the cell-ECM adhesions", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10523740", "species_10523745" ], "products": [ "species_10523747" ], "modifiers": [], "additional_components": [ "WBGene00006999", "WBGene00006836", "Q18685", "WBGene00006836", "Q9U3F4", "WBGene00006999" ] }, "reaction_10524049": { "compartment": "compartment_70101", "id": "reaction_10524049", "reactome": "R-CEL-432897", "name": "ILK interacts with beta-1 integrin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10524045", "species_10514200" ], "products": [ "species_10524047" ], "modifiers": [], "additional_components": [ "WBGene00003931", "WBGene00003930", "Q27874", "WBGene00003930", "Q9TZC4", "WBGene00003931" ] }, "reaction_10523759": { "compartment": "compartment_70101", "id": "reaction_10523759", "reactome": "R-CEL-430347", "name": "MigFilin associates with Filamin and F-actin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10523740", "species_10523755", "species_10523753" ], "products": [ "species_10523757" ], "modifiers": [], "additional_components": [ "WBGene00006999", "P0DM41", "WBGene00000063", "P0DM42", "WBGene00000065", "P10984", "WBGene00000064", "P10986", "WBGene00000066", "species_29358", "U4PBJ9", "WBGene00022048", "D0VWL6", "WBGene00016006", "U4PBJ9", "WBGene00022048", "D0VWL6", "WBGene00016006", "P0DM41", "WBGene00000063", "P0DM42", "WBGene00000065", "P10984", "WBGene00000064", "P10986", "WBGene00000066", "species_29358", "Q9U3F4", "WBGene00006999" ] }, "reaction_10525199": { "compartment": "compartment_70101", "id": "reaction_10525199", "reactome": "R-CEL-446364", "name": "Migfilin interacts with VASP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10523740", "species_10525195" ], "products": [ "species_10525197" ], "modifiers": [], "additional_components": [ "WBGene00006999", "WBGene00006770", "G5EG53", "WBGene00006770", "Q9U3F4", "WBGene00006999" ] }, "reaction_10513001": { "compartment": "compartment_876", "id": "reaction_10513001", "reactome": "R-CEL-190519", "name": "Internalization of gap junction plaques", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10512942", "species_10512947" ], "products": [ "species_10512999" ], "modifiers": [], "additional_components": [ "A0A486WXX8", "WBGene00000894", "P35603", "WBGene00001082", "WBGene00002041", "U4PBY2", "WBGene00002041", "P35603", "WBGene00001082", "A0A486WXX8", "WBGene00000894" ] }, "reaction_10513003": { "compartment": "compartment_70101", "id": "reaction_10513003", "reactome": "R-CEL-190829", "name": "Lysosomal degradation of gap junction plaques", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10512999" ], "products": [], "modifiers": [], "additional_components": [ "U4PBY2", "WBGene00002041", "P35603", "WBGene00001082", "A0A486WXX8", "WBGene00000894" ] }, "reaction_10508138": { "compartment": "compartment_7660", "id": "reaction_10508138", "reactome": "R-CEL-77071", "name": "Phosphorylation (Ser5) of RNA pol II CTD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10508135" ], "products": [ "species_113582", "species_10508131" ], "modifiers": [ [ "species_10508135", "catalyst" ] ], "additional_components": [ "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529" ] }, "reaction_10509405": { "compartment": "compartment_7660", "id": "reaction_10509405", "reactome": "R-CEL-113430", "name": "Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508135" ], "products": [ "species_10508135" ], "modifiers": [], "additional_components": [ "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529" ] }, "reaction_10558214": { "compartment": "compartment_984", "id": "reaction_10558214", "reactome": "R-CEL-6786652", "name": "CHIT1 hydrolyses CHIT to 3xADGP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_6786654" ], "products": [ "species_6786660" ], "modifiers": [ [ "species_10558211", "catalyst" ] ], "additional_components": [ "WBGene00000503" ] }, "reaction_10512728": { "compartment": "compartment_984", "id": "reaction_10512728", "reactome": "R-CEL-189062", "name": "lactose + H2O => D-glucose + D-galactose", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_188973", "species_109276" ], "products": [ "species_70115", "species_188995" ], "modifiers": [ [ "species_10512725", "catalyst" ] ], "additional_components": [ "Q18758", "WBGene00016848" ] }, "reaction_10513005": { "compartment": "compartment_984", "id": "reaction_10513005", "reactome": "R-CEL-191114", "name": "Digestion of branched starch (amylopectin) by extracellular amylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_189071" ], "products": [ "species_191103", "species_188986", "species_189108" ], "modifiers": [ [ "species_10512715", "catalyst" ] ], "additional_components": [ "species_70113", "WBGene00008220" ] }, "reaction_10512718": { "compartment": "compartment_984", "id": "reaction_10512718", "reactome": "R-CEL-188979", "name": "Digestion of linear starch (amylose) by extracellular amylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_189075" ], "products": [ "species_191103", "species_188986" ], "modifiers": [ [ "species_10512715", "catalyst" ] ], "additional_components": [ "species_70113", "WBGene00008220" ] }, "reaction_10556729": { "compartment": "compartment_7660", "id": "reaction_10556729", "reactome": "R-CEL-5691001", "name": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30555", "species_10556726" ], "products": [ "species_113541", "species_10556722" ], "modifiers": [ [ "species_10556726", "catalyst" ] ], "additional_components": [ "Q95Y97", "WBGene00019767", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "P90829", "WBGene00008645", "Q19366", "WBGene00008722", "Q21730", "WBGene00011016", "O02115", "WBGene00003955", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "P34409", "WBGene00017696", "Q95Y97", "WBGene00019767", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "P90829", "WBGene00008645", "Q19366", "WBGene00008722", "Q21730", "WBGene00011016", "O02115", "WBGene00003955", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "P34409", "WBGene00017696", "Q95Y97", "WBGene00019767", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "P90829", "WBGene00008645", "Q19366", "WBGene00008722", "Q21730", "WBGene00011016", "O02115", "WBGene00003955", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "P34409", "WBGene00017696" ] }, "reaction_10556724": { "compartment": "compartment_7660", "id": "reaction_10556724", "reactome": "R-CEL-5691000", "name": "TFIIH binds GG-NER site to form a verification complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10556156", "species_10506316" ], "products": [ "species_10556158" ], "modifiers": [], "additional_components": [ "Q23457", "WBGene00004320", "Q17392", "WBGene00000839", "Q21554", "WBGene00010890", "P30644", "WBGene00011145", "Q23451", "WBGene00013924", "Q9N4C3", "WBGene00022296", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q23457", "WBGene00004320", "Q17392", "WBGene00000839", "Q21554", "WBGene00010890", "P30644", "WBGene00011145", "Q23451", "WBGene00013924", "Q9N4C3", "WBGene00022296", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725" ] }, "reaction_10556164": { "compartment": "compartment_7660", "id": "reaction_10556164", "reactome": "R-CEL-5689861", "name": "Recruitment of XPA and release of CAK ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10556158", "species_10556135" ], "products": [ "species_10506279", "species_10556162" ], "modifiers": [], "additional_components": [ "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q23457", "WBGene00004320", "Q17392", "WBGene00000839", "Q21554", "WBGene00010890", "P30644", "WBGene00011145", "Q23451", "WBGene00013924", "Q9N4C3", "WBGene00022296", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "WBGene00006963", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "K8F7X5", "WBGene00013529", "Q95PZ4", "WBGene00013441", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "P34567", "WBGene00011814", "Q9N3L2", "WBGene00021752", "Q21302", "WBGene00006963", "Q23457", "WBGene00004320", "Q17392", "WBGene00000839", "Q21554", "WBGene00010890", "P30644", "WBGene00011145", "Q23451", "WBGene00013924", "Q9N4C3", "WBGene00022296", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725" ] }, "reaction_10558516": { "compartment": "compartment_7660", "id": "reaction_10558516", "reactome": "R-CEL-6790454", "name": "SUMOylation of XPC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10556715", "species_10558502" ], "products": [ "species_10558511", "species_10546073" ], "modifiers": [ [ "species_10558513", "catalyst" ] ], "additional_components": [ "K8F7X5", "WBGene00013529", "Q95PZ4", "WBGene00013441", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "P34567", "WBGene00011814", "Q9N3L2", "WBGene00021752", "Q21302", "WBGene00006963", "Q23457", "WBGene00004320", "Q17392", "WBGene00000839", "Q21554", "WBGene00010890", "P30644", "WBGene00011145", "Q23451", "WBGene00013924", "Q9N4C3", "WBGene00022296", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "Q23457", "WBGene00004320", "Q17392", "WBGene00000839", "Q21554", "WBGene00010890", "K8F7X5", "WBGene00013529", "Q95PZ4", "WBGene00013441", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "P34567", "WBGene00011814", "Q9N3L2", "WBGene00021752", "Q21302", "WBGene00006963", "P30644", "WBGene00011145", "Q23451", "WBGene00013924", "P55853", "WBGene00004888", "Q9N4C3", "WBGene00022296", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "WBGene00006706" ] }, "reaction_10508629": { "compartment": "compartment_7660", "id": "reaction_10508629", "reactome": "R-CEL-109955", "name": "Formation of ERCC1:XPF heterodimeric complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508620", "species_10508625" ], "products": [ "species_10508627" ], "modifiers": [], "additional_components": [ "WBGene00008665", "WBGene00008140", "G5EBZ1", "WBGene00008140", "Q93456", "WBGene00008665" ] }, "reaction_10556718": { "compartment": "compartment_7660", "id": "reaction_10556718", "reactome": "R-CEL-5690996", "name": "ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10556711" ], "products": [ "species_113550", "species_113582", "species_10556715" ], "modifiers": [ [ "species_10556711", "catalyst" ] ], "additional_components": [ "K8F7X5", "WBGene00013529", "Q95PZ4", "WBGene00013441", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "P34567", "WBGene00011814", "Q9N3L2", "WBGene00021752", "Q21302", "WBGene00006963", "Q23457", "WBGene00004320", "Q17392", "WBGene00000839", "Q21554", "WBGene00010890", "P30644", "WBGene00011145", "Q23451", "WBGene00013924", "Q9N4C3", "WBGene00022296", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "K8F7X5", "WBGene00013529", "Q95PZ4", "WBGene00013441", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "P34567", "WBGene00011814", "Q9N3L2", "WBGene00021752", "Q21302", "WBGene00006963", "Q23457", "WBGene00004320", "Q17392", "WBGene00000839", "Q21554", "WBGene00010890", "P30644", "WBGene00011145", "Q23451", "WBGene00013924", "Q9N4C3", "WBGene00022296", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "K8F7X5", "WBGene00013529", "Q95PZ4", "WBGene00013441", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "P34567", "WBGene00011814", "Q9N3L2", "WBGene00021752", "Q21302", "WBGene00006963", "Q23457", "WBGene00004320", "Q17392", "WBGene00000839", "Q21554", "WBGene00010890", "P30644", "WBGene00011145", "Q23451", "WBGene00013924", "Q9N4C3", "WBGene00022296", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725" ] }, "reaction_10544211": { "compartment": "compartment_984", "id": "reaction_10544211", "reactome": "R-CEL-2424243", "name": "SPARC binds Collagen type I fibril, hydroxylapatite and Ca2+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2672070", "species_10509625", "species_10526518", "species_74112" ], "products": [ "species_10544209" ], "modifiers": [], "additional_components": [ "Q9N4U2", "WBGene00000647", "WBGene00003893", "species_74016", "P34714", "WBGene00003893", "Q9N4U2", "WBGene00000647", "species_2672070" ] }, "reaction_10544420": { "compartment": "compartment_984", "id": "reaction_10544420", "reactome": "R-CEL-2467665", "name": "AGRN binds Beta amyloid fibril via GAG chains", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10544412", "species_10544416" ], "products": [ "species_10544418" ], "modifiers": [], "additional_components": [ "Q10651", "WBGene00000149", "Q10651", "WBGene00000149", "P34710", "unc-6" ] }, "reaction_10545273": { "compartment": "compartment_876", "id": "reaction_10545273", "reactome": "R-CEL-2681667", "name": "TNC binds Integrin alphaVbeta3, alphaVbeta6, alpha2beta1, alpha7beta1, alpha8beta1, alpha9beta1, alphaXbeta1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10517415", "species_10545269" ], "products": [ "species_10545271" ], "modifiers": [], "additional_components": [ "Q18096", "WBGene00007687", "P34446", "WBGene00003929", "Q27874", "WBGene00003930", "Q03600", "WBGene00002081", "P34446", "WBGene00003929", "Q27874", "WBGene00003930", "Q03600", "WBGene00002081", "Q18096", "WBGene00007687" ] }, "reaction_10545277": { "compartment": "compartment_984", "id": "reaction_10545277", "reactome": "R-CEL-2681681", "name": "Tenascins C, R, (X, N) bind fibronectin matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10544239", "species_10517394" ], "products": [ "species_10545275" ], "modifiers": [], "additional_components": [ "Q18096", "WBGene00007687", "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769", "Q18096", "WBGene00007687" ] }, "reaction_10557840": { "compartment": "compartment_7660", "id": "reaction_10557840", "reactome": "R-CEL-6781818", "name": "RNA Pol II initiates transcription from damaged DNA template", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10504431", "species_10506316", "species_5688114" ], "products": [ "species_10557838" ], "modifiers": [], "additional_components": [ "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529" ] }, "reaction_10557845": { "compartment": "compartment_7660", "id": "reaction_10557845", "reactome": "R-CEL-6781824", "name": "Active RNA Pol II complex transcribes lesion-containing DNA template", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10557838", "species_6781829" ], "products": [ "species_113541", "species_10557842" ], "modifiers": [ [ "species_10557838", "catalyst" ] ], "additional_components": [ "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529" ] }, "reaction_10557865": { "compartment": "compartment_7660", "id": "reaction_10557865", "reactome": "R-CEL-6781833", "name": "ERCC8 (CSA) binds stalled RNA Pol II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10557852", "species_10557861" ], "products": [ "species_10557863", "species_10556775" ], "modifiers": [], "additional_components": [ "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q86D18", "WBGene00010011", "Q18963", "WBGene00008403", "Q21554", "WBGene00010890", "Q23457", "WBGene00004320", "Q17392", "WBGene00000839", "Q9GS00", "WBGene00000813", "Q9N359", "WBGene00000816", "P91001", "WBGene00000817", "O01422", "WBGene00000814", "Q9N425", "WBGene00000815", "Q95PZ0", "WBGene00000818", "Q18963", "WBGene00008403", "Q21554", "WBGene00010890", "Q23457", "WBGene00004320", "Q17392", "WBGene00000839", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q86D18", "WBGene00010011", "Q9GS00", "WBGene00000813", "Q9N359", "WBGene00000816", "P91001", "WBGene00000817", "O01422", "WBGene00000814", "Q9N425", "WBGene00000815", "Q95PZ0", "WBGene00000818" ] }, "reaction_10557913": { "compartment": "compartment_7660", "id": "reaction_10557913", "reactome": "R-CEL-6782069", "name": "UVSSA:USP7 deubiquitinates ERCC6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10557904" ], "products": [ "species_10502318", "species_10557910" ], "modifiers": [ [ "species_10557904", "catalyst" ] ], "additional_components": [ "Q23088", "WBGene00022812", "Q7JKC3", "WBGene00010406", "P34545", "WBGene00000366", "Q21302", "WBGene00006963", "H2KYV0", "WBGene00016115", "P52652", "WBGene00012000", "Q18963", "WBGene00008403", "Q21554", "WBGene00010890", "Q23457", "WBGene00004320", "Q17392", "WBGene00000839", "Q19826", "WBGene00017830", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "O02092", "WBGene00018391", "Q9GR61", "WBGene00021347", "Q9N3C9", "WBGene00021845", "Q93338", "WBGene00007971", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q86D18", "WBGene00010011", "Q10051", "WBGene00020423", "Q20716", "WBGene00009966", "Q9U1Q7", "WBGene00001258", "Q9U2S6", "WBGene00000889", "P52009", "WBGene00000877", "P52016", "WBGene00000884", "P91175", "WBGene00016837", "Q22139", "WBGene00011411", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "Q23088", "WBGene00022812", "Q7JKC3", "WBGene00010406", "P34545", "WBGene00000366", "Q18963", "WBGene00008403", "Q21554", "WBGene00010890", "Q23457", "WBGene00004320", "Q17392", "WBGene00000839", "Q19826", "WBGene00017830", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "O02092", "WBGene00018391", "Q9GR61", "WBGene00021347", "Q9N3C9", "WBGene00021845", "Q93338", "WBGene00007971", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q86D18", "WBGene00010011", "Q21302", "WBGene00006963", "H2KYV0", "WBGene00016115", "P52652", "WBGene00012000", "Q10051", "WBGene00020423", "Q20716", "WBGene00009966", "Q9U1Q7", "WBGene00001258", "Q9U2S6", "WBGene00000889", "P52009", "WBGene00000877", "P52016", "WBGene00000884", "P91175", "WBGene00016837", "Q22139", "WBGene00011411", "Q23088", "WBGene00022812", "Q7JKC3", "WBGene00010406", "P34545", "WBGene00000366", "Q21302", "WBGene00006963", "H2KYV0", "WBGene00016115", "P52652", "WBGene00012000", "Q18963", "WBGene00008403", "Q21554", "WBGene00010890", "Q23457", "WBGene00004320", "Q17392", "WBGene00000839", "Q19826", "WBGene00017830", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "O02092", "WBGene00018391", "Q9GR61", "WBGene00021347", "Q9N3C9", "WBGene00021845", "Q93338", "WBGene00007971", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q86D18", "WBGene00010011", "Q10051", "WBGene00020423", "Q20716", "WBGene00009966", "Q9U1Q7", "WBGene00001258", "Q9U2S6", "WBGene00000889", "P52009", "WBGene00000877", "P52016", "WBGene00000884", "P91175", "WBGene00016837", "Q22139", "WBGene00011411" ] }, "reaction_10557867": { "compartment": "compartment_7660", "id": "reaction_10557867", "reactome": "R-CEL-6781840", "name": "ERCC6 binds stalled RNA Pol II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10557850", "species_10557842" ], "products": [ "species_10557852" ], "modifiers": [], "additional_components": [ "WBGene00010011", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q86D18", "WBGene00010011" ] }, "reaction_10557886": { "compartment": "compartment_7660", "id": "reaction_10557886", "reactome": "R-CEL-6781867", "name": "ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502318", "species_10557863" ], "products": [ "species_10557883" ], "modifiers": [ [ "species_10557863", "catalyst" ] ], "additional_components": [ "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "Q18963", "WBGene00008403", "Q21554", "WBGene00010890", "Q23457", "WBGene00004320", "Q17392", "WBGene00000839", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q86D18", "WBGene00010011", "Q18963", "WBGene00008403", "Q21554", "WBGene00010890", "Q23457", "WBGene00004320", "Q17392", "WBGene00000839", "Q19826", "WBGene00017830", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "O02092", "WBGene00018391", "Q9GR61", "WBGene00021347", "Q9N3C9", "WBGene00021845", "Q93338", "WBGene00007971", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q86D18", "WBGene00010011", "Q18963", "WBGene00008403", "Q21554", "WBGene00010890", "Q23457", "WBGene00004320", "Q17392", "WBGene00000839", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q86D18", "WBGene00010011" ] }, "reaction_10543938": { "compartment": "compartment_876", "id": "reaction_10543938", "reactome": "R-CEL-2327746", "name": "FN1 aggregation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10515311", "species_10515319" ], "products": [ "species_10543936" ], "modifiers": [], "additional_components": [ "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769", "P34446", "WBGene00003929", "Q27874", "WBGene00003930", "species_266099", "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769", "P34446", "WBGene00003929", "Q27874", "WBGene00003930" ] }, "reaction_10544859": { "compartment": "compartment_984", "id": "reaction_10544859", "reactome": "R-CEL-2545196", "name": "FN1 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10515311" ], "products": [ "species_10515313" ], "modifiers": [], "additional_components": [ "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769" ] }, "reaction_10564552": { "compartment": "compartment_20699", "id": "reaction_10564552", "reactome": "R-CEL-8847637", "name": "NSF and SNAPs bind the cis-SNARE at the Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10564548", "species_10557329", "species_10557345" ], "products": [ "species_10564550" ], "modifiers": [], "additional_components": [ "Q9TXZ9", "WBGene00015164", "Q20797", "WBGene00006373", "Q95ZW1", "WBGene00017273", "Q94392", "WBGene00003818", "Q18921", "WBGene00017016", "Q94392", "WBGene00003818", "Q18921", "WBGene00017016", "Q9TXZ9", "WBGene00015164", "Q20797", "WBGene00006373", "Q95ZW1", "WBGene00017273" ] }, "reaction_10564571": { "compartment": "compartment_20699", "id": "reaction_10564571", "reactome": "R-CEL-8847887", "name": "RAB33B:GTP binds RIC1:RGP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10564567", "species_10564561" ], "products": [ "species_10564569" ], "modifiers": [], "additional_components": [ "Q7YWW8", "WBGene00010815", "Q09417", "WBGene00011071", "Q20365", "WBGene00004283", "species_29438", "Q20365", "WBGene00004283", "species_29438", "Q7YWW8", "WBGene00010815", "Q09417", "WBGene00011071" ] }, "reaction_10564079": { "compartment": "compartment_20699", "id": "reaction_10564079", "reactome": "R-CEL-6811433", "name": "The COG tethering complex interacts with numerous SNAREs at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10563498", "species_10564075" ], "products": [ "species_10564077" ], "modifiers": [], "additional_components": [ "Q21270", "WBGene00019481", "Q6AW08", "WBGene00022121", "Q95XZ0", "WBGene00021784", "G5EE66", "WBGene00003258", "O44502", "WBGene00019820", "Q21444", "WBGene00000585", "P91151", "WBGene00016608", "Q9TY08", "WBGene00022534", "Q95ZW1", "WBGene00017273", "P41941", "WBGene00007128", "O18230", "WBGene00013302", "Q20797", "WBGene00006373", "H2KYN0", "WBGene00016643", "P83351", "WBGene00019305", "Q9TY08", "WBGene00022534", "Q95ZW1", "WBGene00017273", "P41941", "WBGene00007128", "O18230", "WBGene00013302", "Q20797", "WBGene00006373", "H2KYN0", "WBGene00016643", "P83351", "WBGene00019305", "Q21270", "WBGene00019481", "Q6AW08", "WBGene00022121", "Q95XZ0", "WBGene00021784", "G5EE66", "WBGene00003258", "O44502", "WBGene00019820", "Q21444", "WBGene00000585", "P91151", "WBGene00016608" ] }, "reaction_10564958": { "compartment": "compartment_20699", "id": "reaction_10564958", "reactome": "R-CEL-8849748", "name": "The COG complex binds RABs at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10564954", "species_10563498" ], "products": [ "species_10564956" ], "modifiers": [], "additional_components": [ "species_29438", "Q18969", "WBGene00004286", "Q9XWZ3", "WBGene00004282", "P34213", "WBGene00004269", "Q22782", "WBGene00004270", "Q21270", "WBGene00019481", "Q6AW08", "WBGene00022121", "Q95XZ0", "WBGene00021784", "G5EE66", "WBGene00003258", "O44502", "WBGene00019820", "Q21444", "WBGene00000585", "P91151", "WBGene00016608", "Q21270", "WBGene00019481", "Q6AW08", "WBGene00022121", "Q95XZ0", "WBGene00021784", "G5EE66", "WBGene00003258", "O44502", "WBGene00019820", "Q21444", "WBGene00000585", "P91151", "WBGene00016608", "species_29438", "Q18969", "WBGene00004286", "Q9XWZ3", "WBGene00004282", "P34213", "WBGene00004269", "Q22782", "WBGene00004270" ] }, "reaction_10543921": { "compartment": "compartment_984", "id": "reaction_10543921", "reactome": "R-CEL-2327733", "name": "FN1 binds Collagen types I-V, VII", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10515311", "species_10543917" ], "products": [ "species_10543919" ], "modifiers": [], "additional_components": [ "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769", "Q9N4U2", "WBGene00000647", "O76368", "WBGene00000674", "Q09457", "WBGene00000251", "P17140", "WBGene00002280", "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689", "Q9N4U2", "WBGene00000647", "O76368", "WBGene00000674", "Q09457", "WBGene00000251", "P17140", "WBGene00002280", "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689", "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769" ] } }, "motif_reaction_dictionary": { "reaction_10509451": { "compartment": "compartment_17906", "id": "reaction_10509451", "reactome": "R-CEL-114284", "name": "Release of Cytochrome c from mitochondria", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509449" ], "products": [ "species_10509434" ], "modifiers": [], "additional_components": [ "P19974", "WBGene00017121", "Q23240", "WBGene00013854", "P19974", "WBGene00017121", "Q23240", "WBGene00013854" ] }, "reaction_10554208": { "compartment": "compartment_7660", "id": "reaction_10554208", "reactome": "R-CEL-5651805", "name": "LIG1 bound to APEX1 and PCNA ligates SSB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508820" ], "products": [ "species_10554205" ], "modifiers": [ [ "species_10508820", "catalyst" ] ], "additional_components": [ "G5EBR7", "WBGene00001372", "Q95Y97", "WBGene00019767", "P90829", "WBGene00008645", "Q19366", "WBGene00008722", "Q21730", "WBGene00011016", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "O02115", "WBGene00003955", "Q27474", "WBGene00002985", "G5EBR7", "WBGene00001372", "Q95Y97", "WBGene00019767", "P90829", "WBGene00008645", "Q19366", "WBGene00008722", "Q21730", "WBGene00011016", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "O02115", "WBGene00003955", "Q27474", "WBGene00002985", "G5EBR7", "WBGene00001372", "Q95Y97", "WBGene00019767", "P90829", "WBGene00008645", "Q19366", "WBGene00008722", "Q21730", "WBGene00011016", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "O02115", "WBGene00003955", "Q27474", "WBGene00002985" ] }, "reaction_10508822": { "compartment": "compartment_7660", "id": "reaction_10508822", "reactome": "R-CEL-110371", "name": "LIG1 binds APEX1 and PCNA at SSB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502732", "species_10508818" ], "products": [ "species_10508820" ], "modifiers": [], "additional_components": [ "WBGene00002985", "G5EBR7", "WBGene00001372", "Q95Y97", "WBGene00019767", "P90829", "WBGene00008645", "Q19366", "WBGene00008722", "Q21730", "WBGene00011016", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "O02115", "WBGene00003955", "G5EBR7", "WBGene00001372", "Q95Y97", "WBGene00019767", "P90829", "WBGene00008645", "Q19366", "WBGene00008722", "Q21730", "WBGene00011016", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "O02115", "WBGene00003955", "Q27474", "WBGene00002985" ] }, "reaction_10508814": { "compartment": "compartment_7660", "id": "reaction_10508814", "reactome": "R-CEL-110368", "name": "POLD,POLE-mediated DNA strand displacement synthesis", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30555", "species_10508811" ], "products": [ "species_10508807", "species_113541" ], "modifiers": [ [ "species_10508811", "catalyst" ] ], "additional_components": [ "G5EBR7", "WBGene00001372", "Q95Y97", "WBGene00019767", "P90829", "WBGene00008645", "Q19366", "WBGene00008722", "Q21730", "WBGene00011016", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "O02115", "WBGene00003955", "Q9N3T2", "WBGene00000794", "G5EBR7", "WBGene00001372", "Q95Y97", "WBGene00019767", "P90829", "WBGene00008645", "Q19366", "WBGene00008722", "Q21730", "WBGene00011016", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "O02115", "WBGene00003955", "Q9N3T2", "WBGene00000794", "G5EBR7", "WBGene00001372", "Q95Y97", "WBGene00019767", "P90829", "WBGene00008645", "Q19366", "WBGene00008722", "Q21730", "WBGene00011016", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "O02115", "WBGene00003955", "Q9N3T2", "WBGene00000794" ] }, "reaction_10546996": { "compartment": "compartment_70101", "id": "reaction_10546996", "reactome": "R-CEL-3249379", "name": "p-S407-STAT6 is phosphorylated at Tyr641", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10546994" ], "products": [ "species_10546974", "species_29370" ], "modifiers": [], "additional_components": [ "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111" ] }, "reaction_10546986": { "compartment": "compartment_70101", "id": "reaction_10546986", "reactome": "R-CEL-3249370", "name": "p-S407,Y641-STAT6 dimer migrates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546976" ], "products": [ "species_10546984" ], "modifiers": [], "additional_components": [ "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111" ] }, "reaction_10546988": { "compartment": "compartment_70101", "id": "reaction_10546988", "reactome": "R-CEL-3249372", "name": "p-S407,Y641-STAT6 is dimerized", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546974" ], "products": [ "species_10546976" ], "modifiers": [], "additional_components": [ "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111" ] }, "reaction_10567345": { "compartment": "compartment_70101", "id": "reaction_10567345", "reactome": "R-CEL-8875576", "name": "CRK,CRKL recruits RAC1 GEF to activated MET", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10567341", "species_10567330" ], "products": [ "species_10567343" ], "modifiers": [], "additional_components": [ "G5EDJ4", "WBGene00004928", "Q9XVQ7", "WBGene00008711", "P29355", "WBGene00004774", "Q9NHC3", "WBGene00000416", "Q95XA9", "WBGene00021238", "G5EDJ4", "WBGene00004928", "Q9XVQ7", "WBGene00008711", "P29355", "WBGene00004774", "Q9NHC3", "WBGene00000416", "Q95XA9", "WBGene00021238" ] }, "reaction_10567332": { "compartment": "compartment_70101", "id": "reaction_10567332", "reactome": "R-CEL-8875540", "name": "GAB1 recruits CRK,CRKL to MET", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10520269", "species_10543879" ], "products": [ "species_10567330" ], "modifiers": [], "additional_components": [ "Q9NHC3", "WBGene00000416", "Q95XA9", "WBGene00021238", "G5EDJ4", "WBGene00004928", "Q9XVQ7", "WBGene00008711", "P29355", "WBGene00004774", "G5EDJ4", "WBGene00004928", "Q9XVQ7", "WBGene00008711", "P29355", "WBGene00004774", "Q9NHC3", "WBGene00000416", "Q95XA9", "WBGene00021238" ] }, "reaction_10567348": { "compartment": "compartment_70101", "id": "reaction_10567348", "reactome": "R-CEL-8875591", "name": "DOCK7 activates RAC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10541992" ], "products": [ "species_29420", "species_10509457" ], "modifiers": [ [ "species_10567343", "catalyst" ] ], "additional_components": [ "species_29420", "Q03206", "ced-10", "species_29438", "Q03206", "ced-10", "G5EDJ4", "WBGene00004928", "Q9XVQ7", "WBGene00008711", "P29355", "WBGene00004774", "Q9NHC3", "WBGene00000416", "Q95XA9", "WBGene00021238" ] }, "reaction_10567336": { "compartment": "compartment_70101", "id": "reaction_10567336", "reactome": "R-CEL-8875558", "name": "RAPGEF1 binds CRK,CRKL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10567330", "species_10528529" ], "products": [ "species_10567334" ], "modifiers": [], "additional_components": [ "G5EDJ4", "WBGene00004928", "Q9XVQ7", "WBGene00008711", "P29355", "WBGene00004774", "Q9NHC3", "WBGene00000416", "Q95XA9", "WBGene00021238", "WBGene00021320", "H2KZX7", "WBGene00021320", "G5EDJ4", "WBGene00004928", "Q9XVQ7", "WBGene00008711", "P29355", "WBGene00004774", "Q9NHC3", "WBGene00000416", "Q95XA9", "WBGene00021238" ] }, "reaction_10567339": { "compartment": "compartment_876", "id": "reaction_10567339", "reactome": "R-CEL-8875568", "name": "RAPGEF1 activates RAP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10518265" ], "products": [ "species_29420", "species_10518164" ], "modifiers": [ [ "species_10567334", "catalyst" ] ], "additional_components": [ "Q18246", "WBGene00004307", "species_29420", "Q18246", "WBGene00004307", "species_29438", "H2KZX7", "WBGene00021320", "G5EDJ4", "WBGene00004928", "Q9XVQ7", "WBGene00008711", "P29355", "WBGene00004774", "Q9NHC3", "WBGene00000416", "Q95XA9", "WBGene00021238" ] }, "reaction_10502772": { "compartment": "compartment_7660", "id": "reaction_10502772", "reactome": "R-CEL-69562", "name": "Inactivation of Cyclin E:Cdk2 complexes by p27/p21", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502767", "species_10502749" ], "products": [ "species_10502769" ], "modifiers": [ [ "species_10502767", "catalyst" ] ], "additional_components": [ "WBGene00000517", "O61847", "WBGene00019362", "O61847", "WBGene00019362", "G5EEJ2", "WBGene00000517", "WBGene00000517" ] }, "reaction_10517476": { "compartment": "compartment_70101", "id": "reaction_10517476", "reactome": "R-CEL-264444", "name": "Autoubiquitination of phospho-COP1(Ser-387 )", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10517469", "species_10502375" ], "products": [ "species_10517473" ], "modifiers": [ [ "species_10517469", "catalyst" ] ], "additional_components": [ "WBGene00003917", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "Q965F9", "WBGene00003917", "WBGene00003917" ] }, "reaction_10517478": { "compartment": "compartment_70101", "id": "reaction_10517478", "reactome": "R-CEL-264458", "name": "Proteasome mediated degradation of COP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10517473" ], "products": [ "species_10502375" ], "modifiers": [ [ "species_10502572", "catalyst" ] ], "additional_components": [ "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "Q965F9", "WBGene00003917", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "P91477", "WBGene00003950", "Q95PZ7", "WBGene00013435", "Q18115", "WBGene00004459", "O62102", "WBGene00003948", "O17071", "WBGene00004504", "Q10920", "WBGene00016623", "P34286", "WBGene00003952", "Q9XTT9", "WBGene00004506", "Q23449", "WBGene00004468", "Q95005", "WBGene00003925", "P46502", "WBGene00004503", "O61792", "WBGene00004464", "O17586", "WBGene00003922", "O76371", "WBGene00004505", "Q20585", "WBGene00004463", "Q95008", "WBGene00003926", "Q18787", "WBGene00004501", "Q20058", "WBGene00009445", "Q9N599", "WBGene00003924", "O16368", "WBGene00004502", "O61742", "WBGene00004466", "Q09583", "WBGene00003928", "Q966I8", "WBGene00003947", "Q04908", "WBGene00004460", "Q9XUV0", "WBGene00003951", "Q27488", "WBGene00003923", "Q9GZH5", "WBGene00004458", "O44156", "WBGene00003927", "Q22253", "WBGene00004465", "O76577", "WBGene00004467", "P90868", "WBGene00003953", "Q19324", "WBGene00004461", "Q17971", "WBGene00007588", "Q23237", "WBGene00003949", "Q20938", "WBGene00004462" ] }, "reaction_10517471": { "compartment": "compartment_13231", "id": "reaction_10517471", "reactome": "R-CEL-264418", "name": "Translocation of COP1 from the nucleus to the cytoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10517467" ], "products": [ "species_10517469" ], "modifiers": [], "additional_components": [ "WBGene00003917", "WBGene00003917" ] }, "reaction_10512670": { "compartment": "compartment_7660", "id": "reaction_10512670", "reactome": "R-CEL-187934", "name": "Inactivation of Cyclin A:Cdk2 complexes by p27/p21", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502767", "species_10511613" ], "products": [ "species_10512663" ], "modifiers": [ [ "species_10502767", "catalyst" ] ], "additional_components": [ "WBGene00000517", "O61847", "WBGene00019362", "O61847", "WBGene00019362", "G5EEJ2", "WBGene00000517", "WBGene00000517" ] }, "reaction_10552354": { "compartment": "compartment_984", "id": "reaction_10552354", "reactome": "R-CEL-5433072", "name": "GGTs hydrolyse glutamate from AFXBO-SG, AFNBO-SG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5490253", "species_109276" ], "products": [ "species_210382", "species_5490235" ], "modifiers": [ [ "species_10552351", "catalyst" ] ], "additional_components": [ "CHEBI:78581", "CHEBI:78587", "CHEBI:78579", "CHEBI:78584", "H2L0B7", "WBGene00020590", "O18256", "WBGene00020590", "Q9N5V4", "WBGene00020590", "A0A486WVP7", "WBGene00020590", "B5BM47", "WBGene00020590" ] }, "reaction_10552364": { "compartment": "compartment_70101", "id": "reaction_10552364", "reactome": "R-CEL-5433074", "name": "ACY1:Zn2+ dimer hydrolyses mercapturic acids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5490236", "species_29356" ], "products": [ "species_2022890", "species_5490231" ], "modifiers": [ [ "species_10552361", "catalyst" ] ], "additional_components": [ "CHEBI:78580", "CHEBI:78585", "CHEBI:78583", "CHEBI:78578", "species_216785", "Q5WRS4", "WBGene00015509" ] }, "reaction_10525168": { "compartment": "compartment_12045", "id": "reaction_10525168", "reactome": "R-CEL-446214", "name": "Synthesis of dolichyl-phosphate-glucose", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449299", "species_29410" ], "products": [ "species_532214", "species_110096" ], "modifiers": [ [ "species_10525165", "catalyst" ] ], "additional_components": [ "WBGene00019276" ] }, "reaction_10563798": { "compartment": "compartment_70101", "id": "reaction_10563798", "reactome": "R-CEL-6810464", "name": "NUDT14 hydrolyses UDP-Glc to G1P and UMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_29410" ], "products": [ "species_29548", "species_109402" ], "modifiers": [ [ "species_10563795", "catalyst" ] ], "additional_components": [ "WBGene00008238" ] }, "reaction_10529329": { "compartment": "compartment_70101", "id": "reaction_10529329", "reactome": "R-CEL-927889", "name": "SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10529324", "species_113592" ], "products": [ "species_10529326", "species_29370" ], "modifiers": [ [ "species_10529324", "catalyst" ] ], "additional_components": [ "P91914", "WBGene00004441", "Q19869", "WBGene00004440", "O01868", "WBGene00004436", "P48162", "WBGene00004438", "P52819", "WBGene00004434", "P48158", "WBGene00004435", "Q09533", "WBGene00004421", "P34334", "WBGene00004433", "O02639", "WBGene00004431", "Q95Y90", "WBGene00004420", "O44480", "WBGene00004432", "Q22716", "WBGene00004446", "Q9U332", "WBGene00004445", "Q9XWS4", "WBGene00004444", "P52814", "WBGene00004453", "O45226", "WBGene00004443", "Q21930", "WBGene00004442", "P48166", "WBGene00004454", "Q9BKU5", "WBGene00021350", "P50880", "WBGene00004414", "P61866", "WBGene00004424", "O17570", "WBGene00004452", "Q19162", "WBGene00004423", "Q9U2A8", "WBGene00004456", "Q9N4I4", "WBGene00004412", "O62388", "WBGene00012179", "O01504", 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"reaction_10529308": { "compartment": "compartment_70101", "id": "reaction_10529308", "reactome": "R-CEL-927836", "name": "SMG6 hydrolyzes mRNA with premature termination codon", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10529305" ], "products": [ "species_10529290" ], "modifiers": [ [ "species_10529305", "catalyst" ] ], "additional_components": [ "Q8WQF3", "WBGene00004882", "O76512", "WBGene00004880", "P91914", "WBGene00004441", "Q19869", "WBGene00004440", "O01868", "WBGene00004436", "P48162", "WBGene00004438", "P52819", "WBGene00004434", "P48158", "WBGene00004435", "Q09533", "WBGene00004421", "P34334", "WBGene00004433", "O02639", "WBGene00004431", "Q95Y90", "WBGene00004420", "O44480", "WBGene00004432", "Q22716", "WBGene00004446", "Q9U332", "WBGene00004445", "Q9XWS4", "WBGene00004444", "P52814", "WBGene00004453", "O45226", "WBGene00004443", "Q21930", "WBGene00004442", "P48166", "WBGene00004454", "Q9BKU5", "WBGene00021350", "P50880", "WBGene00004414", "P61866", "WBGene00004424", "O17570", "WBGene00004452", "Q19162", "WBGene00004423", "Q9U2A8", "WBGene00004456", "Q9N4I4", "WBGene00004412", "O62388", 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"WBGene00004484", "Q95Y04", "WBGene00004497", "Q22054", "WBGene00004485", "P90983", "WBGene00004498", "O01692", "WBGene00004486", "P48152", "WBGene00004472", "O18240", "WBGene00004487", "O18650", "WBGene00004488", "P48154", "WBGene00004470", "O17218", "WBGene00004491", "P49041", "WBGene00004474", "C2BR97", "WBGene00004881", "G5EDE4", "WBGene00012343", "Q21832", "WBGene00004387", "P49029", "WBGene00003123", "Q9BL61", "WBGene00022029", "Q21155", "WBGene00004388", "O45622", "WBGene00010405", "species_29420", "A0A486WX07", "WBGene00002066", "Q9U302", "WBGene00003902", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "O16520", "WBGene00020269", "Q09543", "WBGene00003901", "G5EDR3", "WBGene00006352", "G5EGK8", "WBGene00002363", "Q9BL68", "WBGene00004884" ] }, "reaction_10572480": { "compartment": "compartment_70101", "id": "reaction_10572480", "reactome": "R-CEL-9641096", "name": "Misfolded proteins bind PRKN:UBE2N:UBE2V1:Ub", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10572476", "species_10572472" ], "products": [ "species_10572478" ], "modifiers": [], "additional_components": [ "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "Q95XX0", "WBGene00006708", "O45495", "WBGene00006730", "G5ED37", "WBGene00003885", "H2L0N8", "WBGene00021349", "P30644", "WBGene00011145", "P90994", "WBGene00015184", "G5ED37", "WBGene00003885", "H2L0N8", "WBGene00021349", "P30644", "WBGene00011145", "P90994", "WBGene00015184", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "Q95XX0", "WBGene00006708", "O45495", "WBGene00006730" ] }, "reaction_10572551": { "compartment": "compartment_70101", "id": "reaction_10572551", "reactome": "R-CEL-9646348", "name": "PolyUb-Misfolded Proteins:HDAC6 bind dynein motor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10572547", "species_10552960" ], "products": [ "species_10572549" ], "modifiers": [], "additional_components": [ "P90994", "WBGene00015184", "H2L0N8", "WBGene00021349", "P30644", "WBGene00011145", "G5ED37", "WBGene00003885", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "Q19625", "WBGene00003412", "Q95QV2", "WBGene00000477", "Q20296", "WBGene00018319", "Q19020", "WBGene00000962", "O45087", "WBGene00015927", "Q65XS9", "WBGene00043067", "A0AAC1", "WBGene00012424", "Q7YTJ8", "WBGene00012425", "Q21557", "WBGene00010888", "Q22799", "WBGene00001005", "G5ED34", "WBGene00001007", "Q19020", "WBGene00000962", "O45087", "WBGene00015927", "Q65XS9", "WBGene00043067", "A0AAC1", "WBGene00012424", "Q7YTJ8", "WBGene00012425", "Q21557", "WBGene00010888", "Q22799", "WBGene00001005", "G5ED34", "WBGene00001007", "P90994", "WBGene00015184", "H2L0N8", "WBGene00021349", "P30644", "WBGene00011145", "G5ED37", "WBGene00003885", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "Q19625", "WBGene00003412", "Q95QV2", "WBGene00000477", "Q20296", "WBGene00018319" ] }, "reaction_10572520": { "compartment": "compartment_70101", "id": "reaction_10572520", "reactome": "R-CEL-9641111", "name": "Parkin transfers Ub to misfolded proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10572478" ], "products": [ "species_10572518" ], "modifiers": [], "additional_components": [ "G5ED37", "WBGene00003885", "H2L0N8", "WBGene00021349", "P30644", "WBGene00011145", "P90994", "WBGene00015184", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "Q95XX0", "WBGene00006708", "O45495", "WBGene00006730", "Q95XX0", "WBGene00006708", "O45495", "WBGene00006730", "P90994", "WBGene00015184", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "Q19625", "WBGene00003412", "Q95QV2", "WBGene00000477", "H2L0N8", "WBGene00021349", "P30644", "WBGene00011145", "G5ED37", "WBGene00003885" ] }, "reaction_10572522": { "compartment": "compartment_70101", "id": "reaction_10572522", "reactome": "R-CEL-9641127", "name": "Ub:misfolded proteins polymerize to PolyUb:misfolded proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10572518" ], "products": [ "species_10572500" ], "modifiers": [], "additional_components": [ "Q95XX0", "WBGene00006708", "O45495", "WBGene00006730", "P90994", "WBGene00015184", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "Q19625", "WBGene00003412", "Q95QV2", "WBGene00000477", "H2L0N8", "WBGene00021349", "P30644", "WBGene00011145", "G5ED37", "WBGene00003885", "Q95XX0", "WBGene00006708", "O45495", "WBGene00006730", "P90994", "WBGene00015184", "H2L0N8", "WBGene00021349", "P30644", "WBGene00011145", "G5ED37", "WBGene00003885", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "Q19625", "WBGene00003412", "Q95QV2", "WBGene00000477" ] }, "reaction_10550384": { "compartment": "compartment_70101", "id": "reaction_10550384", "reactome": "R-CEL-5205649", "name": "p62 links damaged mitochondria to LC3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10550378", "species_10550373" ], "products": [ "species_10550382" ], "modifiers": [], "additional_components": [ "WBGene00002981", "Q23424", "WBGene00001509", "Q17746", "WBGene00015552", "Q18746", "WBGene00008236", "Q21752", "WBGene00019900", "Q23424", "WBGene00001509", "Q17746", "WBGene00015552", "Q18746", "WBGene00008236", "Q21752", "WBGene00019900", "Q23536", "WBGene00002981" ] }, "reaction_10550417": { "compartment": "compartment_17927", "id": "reaction_10550417", "reactome": "R-CEL-5205681", "name": "Pink1 is cleaved on healthy mitochondria", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10550393" ], "products": [ "species_10550415" ], "modifiers": [], "additional_components": [ "WBGene00017137", "WBGene00017137" ] }, "reaction_10550409": { "compartment": "compartment_21994", "id": "reaction_10550409", "reactome": "R-CEL-5205663", "name": "LC3 binds the autophagosome membrane Atg5-Atg12 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10550382", "species_10550405" ], "products": [ "species_10550407" ], "modifiers": [], "additional_components": [ "Q23424", "WBGene00001509", "Q17746", "WBGene00015552", "Q18746", "WBGene00008236", "Q21752", "WBGene00019900", "Q23536", "WBGene00002981", "Q3V5I7", "WBGene00022152", "Q10931", "WBGene00002982", "Q3V5I7", "WBGene00022152", "Q10931", "WBGene00002982", "Q23424", "WBGene00001509", "Q17746", "WBGene00015552", "Q18746", "WBGene00008236", "Q21752", "WBGene00019900", "Q23536", "WBGene00002981" ] }, "reaction_10550411": { "compartment": "compartment_17906", "id": "reaction_10550411", "reactome": "R-CEL-5205672", "name": "Uncleaved Pink1 accumulates in damaged mitochondria", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10550393" ], "products": [ "species_10550389" ], "modifiers": [], "additional_components": [ "WBGene00017137", "WBGene00017137" ] }, "reaction_10550413": { "compartment": "compartment_70101", "id": "reaction_10550413", "reactome": "R-CEL-5205673", "name": "p62 binds ubiquitinated mitochondrial substrates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10550366", "species_10550360", "species_10550371", "species_10550354", "species_10550352" ], "products": [ "species_10550373" ], "modifiers": [], "additional_components": [ "WBGene00019900", "WBGene00008236", "WBGene00015552", "WBGene00001509", "WBGene00001509", "Q23424", "WBGene00001509", "Q17746", "WBGene00015552", "Q18746", "WBGene00008236", "Q21752", "WBGene00019900" ] }, "reaction_10568834": { "compartment": "compartment_17906", "id": "reaction_10568834", "reactome": "R-CEL-8948146", "name": "FUNDC1 is phosphorylated by ULK1 at Ser17", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10568806" ], "products": [ "species_10568831", "species_29370" ], "modifiers": [ [ "species_10568813", "catalyst" ] ], "additional_components": [ "WBGene00011528", "WBGene00011528", "WBGene00006786" ] }, "reaction_10570165": { "compartment": "compartment_70101", "id": "reaction_10570165", "reactome": "R-CEL-8959573", "name": "Phosphorylated FUNDC1 links damaged mitochondria to LC3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10568831", "species_10550378" ], "products": [ "species_10570159" ], "modifiers": [], "additional_components": [ "WBGene00011528", "WBGene00002981", "Q23536", "WBGene00002981", "Q22252", "WBGene00011528" ] }, "reaction_10568823": { "compartment": "compartment_70101", "id": "reaction_10568823", "reactome": "R-CEL-8948139", "name": "p-S13-FUNDC1 is dephosphorylated by PGAM5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10568809" ], "products": [ "species_10568806" ], "modifiers": [ [ "species_10568820", "catalyst" ] ], "additional_components": [ "WBGene00011528", "WBGene00011528", "WBGene00019941" ] }, "reaction_10568811": { "compartment": "compartment_70101", "id": "reaction_10568811", "reactome": "R-CEL-8948039", "name": "FUNDC1 is phosphorylated by CK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10568806" ], "products": [ "species_29370", "species_10568809" ], "modifiers": [ [ "species_10515097", "catalyst" ] ], "additional_components": [ "WBGene00011528", "WBGene00011528", "P18334", "WBGene00002191", "P28548", "WBGene00002196" ] }, "reaction_10568828": { "compartment": "compartment_70101", "id": "reaction_10568828", "reactome": "R-CEL-8948143", "name": "p-S13, FUNDC1 is phosphorylated by CK2 at Tyr18", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10568809" ], "products": [ "species_10568826", "species_29370" ], "modifiers": [ [ "species_10513079", "catalyst" ] ], "additional_components": [ "WBGene00011528", "WBGene00011528", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635" ] }, "reaction_10568815": { "compartment": "compartment_17906", "id": "reaction_10568815", "reactome": "R-CEL-8948136", "name": "ULK1 Translocates to the mitochondria", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10554651" ], "products": [ "species_10568813" ], "modifiers": [], "additional_components": [ "WBGene00006786", "WBGene00006786" ] }, "reaction_10527767": { "compartment": "compartment_984", "id": "reaction_10527767", "reactome": "R-CEL-629588", "name": "Binding of acetylcholine to highly sodium permeable postsynaptic acetylcholine receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10527685", "species_372533" ], "products": [ "species_10527687" ], "modifiers": [], "additional_components": [ "G5EDF1", "WBGene00000051", "Q93329", "WBGene00002975", "O17274", "WBGene00020836", "Q9N4M3", "WBGene00000045", "P48181", "WBGene00006765", "Q9N587", "WBGene00006797", "P48182", "WBGene00000042", "Q23022", "WBGene00006774", "Q23355", "WBGene00000047", "Q27218", "WBGene00002974", "Q93149", "WBGene00000043", "H2KZY7", "WBGene00022283", "species_372533", "G5EDF1", "WBGene00000051", "Q93329", "WBGene00002975", "O17274", "WBGene00020836", "Q9N4M3", "WBGene00000045", "P48181", "WBGene00006765", "Q9N587", "WBGene00006797", "P48182", "WBGene00000042", "Q23022", "WBGene00006774", "Q23355", "WBGene00000047", "Q27218", "WBGene00002974", "Q93149", "WBGene00000043", "H2KZY7", "WBGene00022283" ] }, "reaction_10527690": { "compartment": "compartment_876", "id": "reaction_10527690", "reactome": "R-CEL-622325", "name": "Activation of highly sodium permeable postsynaptic nicotinic acetylcholine receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74113" ], "products": [ "species_83910" ], "modifiers": [ [ "species_10527687", "catalyst" ] ], "additional_components": [ "species_372533", "G5EDF1", "WBGene00000051", "Q93329", "WBGene00002975", "O17274", "WBGene00020836", "Q9N4M3", "WBGene00000045", "P48181", "WBGene00006765", "Q9N587", "WBGene00006797", "P48182", "WBGene00000042", "Q23022", "WBGene00006774", "Q23355", "WBGene00000047", "Q27218", "WBGene00002974", "Q93149", "WBGene00000043", "H2KZY7", "WBGene00022283" ] }, "reaction_10564113": { "compartment": "compartment_7660", "id": "reaction_10564113", "reactome": "R-CEL-6811522", "name": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6810408", "species_29358" ], "products": [ "species_113582", "species_6810412" ], "modifiers": [ [ "species_10564110", "catalyst" ] ], "additional_components": [ "Q9BL73", "WBGene00004088" ] }, "reaction_10563787": { "compartment": "compartment_172574", "id": "reaction_10563787", "reactome": "R-CEL-6810392", "name": "TMEM55B translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10563783" ], "products": [ "species_10563785" ], "modifiers": [], "additional_components": [ "WBGene00022167", "WBGene00022167" ] }, "reaction_10563790": { "compartment": "compartment_7660", "id": "reaction_10563790", "reactome": "R-CEL-6810410", "name": "PI(4,5)P2 is dephosphorylated to PI5P by TMEM55B in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_6810412" ], "products": [ "species_6810408", "species_113550" ], "modifiers": [ [ "species_10563785", "catalyst" ] ], "additional_components": [ "WBGene00022167" ] }, "reaction_10511490": { "compartment": "compartment_876", "id": "reaction_10511490", "reactome": "R-CEL-170986", "name": "Ral-GDS binds to Ras-GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10511486", "species_10511481" ], "products": [ "species_10511488" ], "modifiers": [], "additional_components": [ "WBGene00017891", "species_29438", "P22981", "WBGene00002335", "species_29438", "P22981", "WBGene00002335", "Q19852", "WBGene00017891" ] }, "reaction_10512661": { "compartment": "compartment_70101", "id": "reaction_10512661", "reactome": "R-CEL-187688", "name": "p38 MAPK phosphorylates MAPKAPK2, MAPKAPK3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10512628" ], "products": [ "species_29370", "species_10512646" ], "modifiers": [ [ "species_10512658", "catalyst" ] ], "additional_components": [ "Q21360", "WBGene00010681", "Q965G5", "WBGene00007007", "Q21360", "WBGene00010681", "Q965G5", "WBGene00007007", "Q17446", "WBGene00004055", "Q8MXI4", "WBGene00004056", "species_114632" ] }, "reaction_10572080": { "compartment": "compartment_70101", "id": "reaction_10572080", "reactome": "R-CEL-9610166", "name": "p-T,Y MAPK dimers translocate to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10542082" ], "products": [ "species_10514067" ], "modifiers": [], "additional_components": [ "P39745", "WBGene00003401", "P39745", "WBGene00003401" ] }, "reaction_10572066": { "compartment": "compartment_74700", "id": "reaction_10572066", "reactome": "R-CEL-9610153", "name": "Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10572055" ], "products": [ "species_10572059", "species_29370" ], "modifiers": [ [ "species_10572055", "catalyst" ] ], "additional_components": [ "Q10664", "WBGene00003186", "Q18246", "WBGene00004307", "species_29438", "species_216785", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "Q07292", "WBGene00003030", "P39745", "WBGene00003401", "Q18246", "WBGene00004307", "species_29438", "species_216785", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "Q07292", "WBGene00003030", "Q10664", "WBGene00003186", "P39745", "WBGene00003401", "Q10664", "WBGene00003186", "Q18246", "WBGene00004307", "species_29438", "species_216785", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "Q07292", "WBGene00003030", "P39745", "WBGene00003401" ] }, "reaction_10572070": { "compartment": "compartment_70101", "id": "reaction_10572070", "reactome": "R-CEL-9610154", "name": "Dissociation of phosphorylated MAP2Ks and MAPKs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10572068" ], "products": [ "species_10555065", "species_10508583", "species_10572053" ], "modifiers": [], "additional_components": [ "Q18246", "WBGene00004307", "species_29438", "species_216785", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "Q07292", "WBGene00003030", "P39745", "WBGene00003401", "Q10664", "WBGene00003186", "Q10664", "WBGene00003186", "WBGene00003401", "Q18246", "WBGene00004307", "species_29438", "species_216785", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "Q07292", "WBGene00003030" ] }, "reaction_10572057": { "compartment": "compartment_74700", "id": "reaction_10572057", "reactome": "R-CEL-9610152", "name": "Activated BRAF recruits MAP2Ks and MAPKs to the endosome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508575", "species_10572053", "species_10555040" ], "products": [ "species_10572055" ], "modifiers": [], "additional_components": [ "WBGene00003401", "Q18246", "WBGene00004307", "species_29438", "species_216785", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "Q07292", "WBGene00003030", "Q10664", "WBGene00003186", "Q10664", "WBGene00003186", "Q18246", "WBGene00004307", "species_29438", "species_216785", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "Q07292", "WBGene00003030", "P39745", "WBGene00003401" ] }, "reaction_10572073": { "compartment": "compartment_70101", "id": "reaction_10572073", "reactome": "R-CEL-9610156", "name": "MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10572059", "species_113592" ], "products": [ "species_29370", "species_10572068" ], "modifiers": [ [ "species_10572059", "catalyst" ] ], "additional_components": [ "Q18246", "WBGene00004307", "species_29438", "species_216785", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "Q07292", "WBGene00003030", "Q10664", "WBGene00003186", "P39745", "WBGene00003401", "Q18246", "WBGene00004307", "species_29438", "species_216785", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "Q07292", "WBGene00003030", "P39745", "WBGene00003401", "Q10664", "WBGene00003186", "Q18246", "WBGene00004307", "species_29438", "species_216785", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "Q07292", "WBGene00003030", "Q10664", "WBGene00003186", "P39745", "WBGene00003401" ] }, "reaction_10555163": { "compartment": "compartment_70101", "id": "reaction_10555163", "reactome": "R-CEL-5674385", "name": "p-T,Y MAPKs dimerize", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508583" ], "products": [ "species_10542082" ], "modifiers": [], "additional_components": [ "WBGene00003401", "P39745", "WBGene00003401" ] }, "reaction_10572078": { "compartment": "compartment_74700", "id": "reaction_10572078", "reactome": "R-CEL-9610163", "name": "BRAF autophosphorylates downstream of RAP1 and NGF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10572075", "species_113592" ], "products": [ "species_29370", "species_10572053" ], "modifiers": [ [ "species_10572075", "catalyst" ] ], "additional_components": [ "Q18246", "WBGene00004307", "species_216785", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "Q07292", "WBGene00003030", "species_29438", "Q18246", "WBGene00004307", "species_29438", "species_216785", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "Q07292", "WBGene00003030", "Q18246", "WBGene00004307", "species_216785", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "Q07292", "WBGene00003030", "species_29438" ] }, "reaction_10572117": { "compartment": "compartment_7660", "id": "reaction_10572117", "reactome": "R-CEL-9612509", "name": "SGK phosphorylates SRF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10572112" ], "products": [ "species_113582", "species_10572115" ], "modifiers": [ [ "species_10572104", "catalyst" ] ], "additional_components": [ "WBGene00006844", "WBGene00006844", "WBGene00004789" ] }, "reaction_10572132": { "compartment": "compartment_7660", "id": "reaction_10572132", "reactome": "R-CEL-9613213", "name": "NAB2 and CHD4 bind and repress EGR-mediated RRAD gene expression", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10572122", "species_10547994", "species_10572128" ], "products": [ "species_10572130" ], "modifiers": [], "additional_components": [ "WBGene00003107", "G5EBZ4", "WBGene00002637", "Q22516", "WBGene00000482", "Q18250", "WBGene00007772", "G5EBZ4", "WBGene00002637", "Q22516", "WBGene00000482", "Q22002", "WBGene00003107", "Q18250", "WBGene00007772" ] }, "reaction_10572107": { "compartment": "compartment_7660", "id": "reaction_10572107", "reactome": "R-CEL-9612501", "name": "SGK phosphorylates CREB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10514243" ], "products": [ "species_113582", "species_10514246" ], "modifiers": [ [ "species_10572104", "catalyst" ] ], "additional_components": [ "WBGene00000793", "WBGene00000793", "WBGene00004789" ] }, "reaction_10514065": { "compartment": "compartment_7660", "id": "reaction_10514065", "reactome": "R-CEL-198746", "name": "ERK1/2/5 activate RSK1/2/3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10514008" ], "products": [ "species_113582", "species_10514054" ], "modifiers": [ [ "species_10514062", "catalyst" ] ], "additional_components": [ "Q19858", "WBGene00017898", "Q21734", "WBGene00011352", "Q21734", "WBGene00011352", "Q19858", "WBGene00017898", "P39745", "WBGene00003401", "H2KYF8", "WBGene00003402" ] }, "reaction_10514435": { "compartment": "compartment_7660", "id": "reaction_10514435", "reactome": "R-CEL-199959", "name": "ERKs are inactivated by protein phosphatase 2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10514062" ], "products": [ "species_113550", "species_10514418" ], "modifiers": [ [ "species_10514432", "catalyst" ] ], "additional_components": [ "P39745", "WBGene00003401", "H2KYF8", "WBGene00003402", "H2KYF8", "WBGene00003402", "P39745", "WBGene00003401", "A9UJN4", "WBGene00007554" ] }, "reaction_10514070": { "compartment": "compartment_7660", "id": "reaction_10514070", "reactome": "R-CEL-198756", "name": "ERK1/2 phosphorylates MSK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10513966" ], "products": [ "species_113582", "species_10513972" ], "modifiers": [ [ "species_10514067", "catalyst" ] ], "additional_components": [ "WBGene00008311", "WBGene00008311", "P39745", "WBGene00003401" ] }, "reaction_10513975": { "compartment": "compartment_7660", "id": "reaction_10513975", "reactome": "R-CEL-198669", "name": "p38MAPK phosphorylates MSK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10513966" ], "products": [ "species_113582", "species_10513972" ], "modifiers": [ [ "species_10510865", "catalyst" ] ], "additional_components": [ "WBGene00008311", "WBGene00008311", "Q17446", "WBGene00004055", "Q8MXI4", "WBGene00004056" ] }, "reaction_10515399": { "compartment": "compartment_7660", "id": "reaction_10515399", "reactome": "R-CEL-203797", "name": "ERKs are inactivated by dual-specific phosphatases (DUSPs)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10514062" ], "products": [ "species_113550", "species_10514418" ], "modifiers": [ [ "species_10515396", "catalyst" ] ], "additional_components": [ "P39745", "WBGene00003401", "H2KYF8", "WBGene00003402", "H2KYF8", "WBGene00003402", "P39745", "WBGene00003401", "Q9XUJ0", "WBGene00012372" ] }, "reaction_10514385": { "compartment": "compartment_7660", "id": "reaction_10514385", "reactome": "R-CEL-199895", "name": "RSK1/2/3 phosphorylates CREB at Serine 133", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10514243" ], "products": [ "species_113582", "species_10514246" ], "modifiers": [ [ "species_10514054", "catalyst" ] ], "additional_components": [ "WBGene00000793", "WBGene00000793", "Q21734", "WBGene00011352", "Q19858", "WBGene00017898" ] }, "reaction_10514402": { "compartment": "compartment_7660", "id": "reaction_10514402", "reactome": "R-CEL-199917", "name": "MAPKAPK2 phosphorylates CREB at Serine 133", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10514243" ], "products": [ "species_113582", "species_10514246" ], "modifiers": [ [ "species_10514399", "catalyst" ] ], "additional_components": [ "WBGene00000793", "WBGene00000793", "Q21360", "WBGene00010681", "Q965G5", "WBGene00007007" ] }, "reaction_10514404": { "compartment": "compartment_7660", "id": "reaction_10514404", "reactome": "R-CEL-199935", "name": "MSK1 activates CREB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10514243" ], "products": [ "species_113582", "species_10514246" ], "modifiers": [ [ "species_10513972", "catalyst" ] ], "additional_components": [ "WBGene00000793", "WBGene00000793", "WBGene00008311" ] }, "reaction_10514393": { "compartment": "compartment_7660", "id": "reaction_10514393", "reactome": "R-CEL-199910", "name": "MSK1 activates ATF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10514387" ], "products": [ "species_113582", "species_10514390" ], "modifiers": [ [ "species_10513972", "catalyst" ] ], "additional_components": [ "WBGene00000793", "WBGene00000793", "WBGene00008311" ] }, "reaction_10513986": { "compartment": "compartment_7660", "id": "reaction_10513986", "reactome": "R-CEL-198714", "name": "ERK5 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10513982" ], "products": [ "species_10513984" ], "modifiers": [], "additional_components": [ "WBGene00003402", "WBGene00003402" ] }, "reaction_10515269": { "compartment": "compartment_876", "id": "reaction_10515269", "reactome": "R-CEL-202692", "name": "PIP3 binds to RhoA and activates it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509484", "species_179838" ], "products": [ "species_10515267" ], "modifiers": [], "additional_components": [ "WBGene00004357", "Q22038", "WBGene00004357", "species_179838" ] }, "reaction_10545459": { "compartment": "compartment_876", "id": "reaction_10545459", "reactome": "R-CEL-2684507", "name": "Syndecans 1, 2, 4, (3) bind FGF2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10512869", "species_10541682" ], "products": [ "species_10545457" ], "modifiers": [], "additional_components": [ "WBGene00002881", "WBGene00004749", "P50605", "WBGene00004749", "Q11184", "WBGene00002881" ] }, "reaction_10545556": { "compartment": "compartment_876", "id": "reaction_10545556", "reactome": "R-CEL-2731074", "name": "Syndecan-1 binds Integrins alpha2beta1, (alpha6beta4)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10541682", "species_10545552" ], "products": [ "species_10545554" ], "modifiers": [], "additional_components": [ "WBGene00004749", "P34446", "WBGene00003929", "Q27874", "WBGene00003930", "P34446", "WBGene00003929", "Q27874", "WBGene00003930", "P50605", "WBGene00004749" ] }, "reaction_10545560": { "compartment": "compartment_876", "id": "reaction_10545560", "reactome": "R-CEL-2731078", "name": "Syndecans 2, (4) bind TGFB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10511429", "species_10541684" ], "products": [ "species_10545558" ], "modifiers": [], "additional_components": [ "G5EBY8", "WBGene00006852", "G5EEL5", "WBGene00000936", "WBGene00004749", "P50605", "WBGene00004749", "G5EBY8", "WBGene00006852", "G5EEL5", "WBGene00000936" ] }, "reaction_10545913": { "compartment": "compartment_876", "id": "reaction_10545913", "reactome": "R-CEL-2750187", "name": "Syndecan-4:PI(4,5)P2 binds PKC alpha:DAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10545909", "species_10521475" ], "products": [ "species_10545911" ], "modifiers": [], "additional_components": [ "species_179856", "P50605", "WBGene00004749", "P90980", "WBGene00004033", "species_114519", "P90980", "WBGene00004033", "species_114519", "species_179856", "P50605", "WBGene00004749" ] }, "reaction_10545564": { "compartment": "compartment_876", "id": "reaction_10545564", "reactome": "R-CEL-2731141", "name": "Syndecan-1 binds fibronectin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10541682", "species_10517394" ], "products": [ "species_10545562" ], "modifiers": [], "additional_components": [ "WBGene00004749", "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769", "P50605", "WBGene00004749" ] }, "reaction_10546406": { "compartment": "compartment_70101", "id": "reaction_10546406", "reactome": "R-CEL-3134954", "name": "DHX9 binds DNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_3134861", "species_10546400" ], "products": [ "species_10546402" ], "modifiers": [], "additional_components": [ "WBGene00004355", "Q22307", "WBGene00004355" ] }, "reaction_10546408": { "compartment": "compartment_70101", "id": "reaction_10546408", "reactome": "R-CEL-3134962", "name": "DHX36 binds DNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546396", "species_3134861" ], "products": [ "species_10546398" ], "modifiers": [], "additional_components": [ "WBGene00009922", "Q20644", "WBGene00009922" ] }, "reaction_10527102": { "compartment": "compartment_984", "id": "reaction_10527102", "reactome": "R-CEL-500708", "name": "GRIK3 homomer binds glutamate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_210382", "species_10526044" ], "products": [ "species_10527100" ], "modifiers": [], "additional_components": [ "A0A1T5HUM0", "WBGene00001618", "O01623", "WBGene00001616", "Q17697", "WBGene00001615", "species_2730999", "A0A1T5HUM0", "WBGene00001618", "O01623", "WBGene00001616", "Q17697", "WBGene00001615", "species_2730999", "species_113552" ] }, "reaction_10526120": { "compartment": "compartment_984", "id": "reaction_10526120", "reactome": "R-CEL-451309", "name": "Edited Kainate Receptor binds glutamate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_210382", "species_10526116" ], "products": [ "species_10526118" ], "modifiers": [], "additional_components": [ "A0A1T5HUM0", "WBGene00001618", "O01623", "WBGene00001616", "Q17697", "WBGene00001615", "species_2730999", "A0A1T5HUM0", "WBGene00001618", "O01623", "WBGene00001616", "Q17697", "WBGene00001615", "species_2730999", "species_113552" ] }, "reaction_10526123": { "compartment": "compartment_984", "id": "reaction_10526123", "reactome": "R-CEL-451310", "name": "Activation of Edited Kainate receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74113" ], "products": [ "species_83910" ], "modifiers": [ [ "species_10526118", "catalyst" ] ], "additional_components": [ "A0A1T5HUM0", "WBGene00001618", "O01623", "WBGene00001616", "Q17697", "WBGene00001615", "species_2730999", "species_113552" ] }, "reaction_10526080": { "compartment": "compartment_876", "id": "reaction_10526080", "reactome": "R-CEL-451283", "name": "kainate receptor binds glutamate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_210382", "species_10526076" ], "products": [ "species_10526078" ], "modifiers": [], "additional_components": [ "G5ECY0", "WBGene00001006", "Q22638", "WBGene00011890", "P36609", "WBGene00003564", "Q11083", "WBGene00020378", "P04630", "WBGene00000285", "G5EF37", "WBGene00003934", "A0A2C9C3L3", "WBGene00020378", "Q18136", "WBGene00006861", "Q09665", "WBGene00006583", "O02159", "WBGene00020378", "G5EDZ8", "WBGene00000288", "Q94288", "WBGene00000287", "Q09980", "WBGene00017394", "O16305", "WBGene00000552", "G5EEG0", "WBGene00000286", "O01623", "WBGene00001616", "Q17697", "WBGene00001615", "A0A1T5HUM0", "WBGene00001618", "species_2730999", "G5ECY0", "WBGene00001006", "Q22638", "WBGene00011890", "P36609", "WBGene00003564", "Q11083", "WBGene00020378", "P04630", "WBGene00000285", "G5EF37", "WBGene00003934", "A0A2C9C3L3", "WBGene00020378", "Q18136", "WBGene00006861", "Q09665", "WBGene00006583", "O02159", "WBGene00020378", "G5EDZ8", "WBGene00000288", "Q94288", "WBGene00000287", "Q09980", "WBGene00017394", "O16305", "WBGene00000552", "G5EEG0", "WBGene00000286", "O01623", "WBGene00001616", "Q17697", "WBGene00001615", "A0A1T5HUM0", "WBGene00001618", "species_2730999", "species_113552" ] }, "reaction_10526126": { "compartment": "compartment_70101", "id": "reaction_10526126", "reactome": "R-CEL-451311", "name": "Activation of Ca-permeable Kainate receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74112" ], "products": [ "species_74016" ], "modifiers": [ [ "species_10526078", "catalyst" ] ], "additional_components": [ "G5ECY0", "WBGene00001006", "Q22638", "WBGene00011890", "P36609", "WBGene00003564", "Q11083", "WBGene00020378", "P04630", "WBGene00000285", "G5EF37", "WBGene00003934", "A0A2C9C3L3", "WBGene00020378", "Q18136", "WBGene00006861", "Q09665", "WBGene00006583", "O02159", "WBGene00020378", "G5EDZ8", "WBGene00000288", "Q94288", "WBGene00000287", "Q09980", "WBGene00017394", "O16305", "WBGene00000552", "G5EEG0", "WBGene00000286", "O01623", "WBGene00001616", "Q17697", "WBGene00001615", "A0A1T5HUM0", "WBGene00001618", "species_2730999", "species_113552" ] }, "reaction_10526193": { "compartment": "compartment_5460", "id": "reaction_10526193", "reactome": "R-CEL-452036", "name": "arginine + H2O => ornithine + urea [ARG2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_374064", "species_113521" ], "products": [ "species_374061", "species_113585" ], "modifiers": [ [ "species_10526190", "catalyst" ] ], "additional_components": [ "species_266099", "A0A1X7RC97", "WBGene00020658" ] }, "reaction_10503273": { "compartment": "compartment_70101", "id": "reaction_10503273", "reactome": "R-CEL-70634", "name": "ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113567", "species_29498" ], "products": [ "species_113585", "species_29968" ], "modifiers": [ [ "species_10503270", "catalyst" ] ], "additional_components": [ "WBGene00020422" ] }, "reaction_10503167": { "compartment": "compartment_70101", "id": "reaction_10503167", "reactome": "R-CEL-70569", "name": "arginine + H2O => ornithine + urea [ARG1]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_29468" ], "products": [ "species_29514", "species_29498" ], "modifiers": [ [ "species_10503164", "catalyst" ] ], "additional_components": [ "A0A1X7RC97", "WBGene00020658", "species_266099" ] }, "reaction_10525558": { "compartment": "compartment_7660", "id": "reaction_10525558", "reactome": "R-CEL-450333", "name": "Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10525555" ], "products": [ "species_113582", "species_10525449" ], "modifiers": [ [ "species_10525533", "catalyst" ] ], "additional_components": [ "Q17446", "WBGene00004055", "Q8MXI4", "WBGene00004056", "Q965G5", "WBGene00007007", "Q21360", "WBGene00010681", "Q17446", "WBGene00004055", "Q8MXI4", "WBGene00004056", "Q965G5", "WBGene00007007", "Q21360", "WBGene00010681", "G5EDF7", "WBGene00004758", "Q58AU7", "WBGene00018034", "Q58AU8", "WBGene00018035" ] }, "reaction_10525464": { "compartment": "compartment_7660", "id": "reaction_10525464", "reactome": "R-CEL-450222", "name": "Active p38 MAPK phosphorylates MAPKAPK2 or 3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10525449" ], "products": [ "species_113582", "species_10525461" ], "modifiers": [ [ "species_10525449", "catalyst" ] ], "additional_components": [ "Q17446", "WBGene00004055", "Q8MXI4", "WBGene00004056", "Q965G5", "WBGene00007007", "Q21360", "WBGene00010681", "Q17446", "WBGene00004055", "Q8MXI4", "WBGene00004056", "Q965G5", "WBGene00007007", "Q21360", "WBGene00010681", "Q17446", "WBGene00004055", "Q8MXI4", "WBGene00004056", "Q965G5", "WBGene00007007", "Q21360", "WBGene00010681" ] }, "reaction_10525468": { "compartment": "compartment_70101", "id": "reaction_10525468", "reactome": "R-CEL-450257", "name": "Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10525461" ], "products": [ "species_10525466" ], "modifiers": [], "additional_components": [ "Q17446", "WBGene00004055", "Q8MXI4", "WBGene00004056", "Q965G5", "WBGene00007007", "Q21360", "WBGene00010681", "Q17446", "WBGene00004055", "Q8MXI4", "WBGene00004056", "Q21360", "WBGene00010681", "Q965G5", "WBGene00007007" ] }, "reaction_10525535": { "compartment": "compartment_70101", "id": "reaction_10525535", "reactome": "R-CEL-450296", "name": "Phosphorylated MKK3/MKK6 migrates to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10525521" ], "products": [ "species_10525533" ], "modifiers": [], "additional_components": [ "Q58AU7", "WBGene00018034", "Q58AU8", "WBGene00018035", "G5EDF7", "WBGene00004758", "G5EDF7", "WBGene00004758", "Q58AU7", "WBGene00018034", "Q58AU8", "WBGene00018035" ] }, "reaction_10525578": { "compartment": "compartment_70101", "id": "reaction_10525578", "reactome": "R-CEL-450348", "name": "Activated human JNKs migrate to nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10510969" ], "products": [ "species_10510908" ], "modifiers": [], "additional_components": [ "Q8WQG9", "WBGene00002178", "H2KZI0", "WBGene00002188", "O44408", "WBGene00002187", "Q8WQG9", "WBGene00002178", "H2KZI0", "WBGene00002188", "O44408", "WBGene00002187" ] }, "reaction_10510988": { "compartment": "compartment_70101", "id": "reaction_10510988", "reactome": "R-CEL-168162", "name": "Phosphorylation of human JNKs by activated MKK4/MKK7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10510949" ], "products": [ "species_29370", "species_10510969" ], "modifiers": [ [ "species_10510985", "catalyst" ] ], "additional_components": [ "Q8WQG9", "WBGene00002178", "H2KZI0", "WBGene00002188", "O44408", "WBGene00002187", "Q8WQG9", "WBGene00002178", "H2KZI0", "WBGene00002188", "O44408", "WBGene00002187", "Q21307", "WBGene00003185", "Q20347", "WBGene00003368" ] }, "reaction_10510992": { "compartment": "compartment_7660", "id": "reaction_10510992", "reactome": "R-CEL-168440", "name": "Formation of Activated Protein 1 (AP-1) complex. ATF2/c-JUN heterodimer. ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10510926", "species_10510845" ], "products": [ "species_10510990" ], "modifiers": [], "additional_components": [ "WBGene00012005", "WBGene00000223", "Q86MD3", "WBGene00000223", "G5ECU7", "WBGene00012005" ] }, "reaction_10510929": { "compartment": "compartment_7660", "id": "reaction_10510929", "reactome": "R-CEL-168136", "name": "Activated JNKs phosphorylate c-JUN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10510922" ], "products": [ "species_113582", "species_10510926" ], "modifiers": [ [ "species_10510908", "catalyst" ] ], "additional_components": [ "WBGene00012005", "WBGene00012005", "Q8WQG9", "WBGene00002178", "H2KZI0", "WBGene00002188", "O44408", "WBGene00002187" ] }, "reaction_10525492": { "compartment": "compartment_7660", "id": "reaction_10525492", "reactome": "R-CEL-450292", "name": "Formation of Activated Protein 1 (AP-1) complex. cFOS/c-JUN heterodimer. ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10510926", "species_10525488" ], "products": [ "species_10525490" ], "modifiers": [], "additional_components": [ "WBGene00012005", "G5ECG2", "WBGene00001345", "Q9N5A8", "WBGene00021082", "G5ECG2", "WBGene00001345", "Q9N5A8", "WBGene00021082", "G5ECU7", "WBGene00012005" ] }, "reaction_10510917": { "compartment": "compartment_7660", "id": "reaction_10510917", "reactome": "R-CEL-168053", "name": "Phosphorylated MAPKs phosphorylate ATF-2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10510841" ], "products": [ "species_113582", "species_10510845" ], "modifiers": [ [ "species_10510914", "catalyst" ] ], "additional_components": [ "WBGene00000223", "WBGene00000223", "Q17446", "WBGene00004055", "Q8MXI4", "WBGene00004056", "Q8WQG9", "WBGene00002178", "H2KZI0", "WBGene00002188", "O44408", "WBGene00002187" ] }, "reaction_10525543": { "compartment": "compartment_7660", "id": "reaction_10525543", "reactome": "R-CEL-450325", "name": "c-FOS activation by phospho ERK1/2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10525541" ], "products": [ "species_113582", "species_10525488" ], "modifiers": [ [ "species_10514067", "catalyst" ] ], "additional_components": [ "G5ECG2", "WBGene00001345", "Q9N5A8", "WBGene00021082", "G5ECG2", "WBGene00001345", "Q9N5A8", "WBGene00021082", "P39745", "WBGene00003401" ] }, "reaction_10528549": { "compartment": "compartment_13231", "id": "reaction_10528549", "reactome": "R-CEL-913529", "name": "Translocation of p-STAT1:p-STAT1 dimer to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10528455" ], "products": [ "species_10528543" ], "modifiers": [ [ "species_10528547", "catalyst" ] ], "additional_components": [ "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q22560", "WBGene00002072", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q9BIB8", "WBGene00002075" ] }, "reaction_10537425": { "compartment": "compartment_70101", "id": "reaction_10537425", "reactome": "R-CEL-1678843", "name": "ISGylation of protein translation regulator 4EHP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10537411", "species_10531955" ], "products": [ "species_10537413" ], "modifiers": [], "additional_components": [ "WBGene00002062", "Q9BL11", "WBGene00021685", "O01965", "WBGene00016158", "P91057", "WBGene00015842", "Q21633", "WBGene00006713", "Q22888", "WBGene00002062", "Q9BL11", "WBGene00021685", "O01965", "WBGene00016158", "P91057", "WBGene00015842", "Q21633", "WBGene00006713" ] }, "reaction_10531986": { "compartment": "compartment_70101", "id": "reaction_10531986", "reactome": "R-CEL-1169404", "name": "Transfer of ISG15 from E1 to E2 (UBCH8)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10529367", "species_10531957" ], "products": [ "species_10529372", "species_10531946" ], "modifiers": [ [ "species_10529367", "catalyst" ] ], "additional_components": [ "WBGene00006713", "P91057", "WBGene00015842", "Q27481", "WBGene00006699", "WBGene00006699", "P91057", "WBGene00015842", "Q21633", "WBGene00006713", "WBGene00006713" ] }, "reaction_10531971": { "compartment": "compartment_70101", "id": "reaction_10531971", "reactome": "R-CEL-1169398", "name": "ISGylation of host protein filamin B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10531966", "species_113592", "species_10531955" ], "products": [ "species_111294", "species_10529367", "species_10531953", "species_76577", "species_10531968" ], "modifiers": [ [ "species_10531955", "catalyst" ] ], "additional_components": [ "D0VWL6", "WBGene00016006", "U4PBJ9", "WBGene00022048", "Q9BL11", "WBGene00021685", "O01965", "WBGene00016158", "P91057", "WBGene00015842", "Q21633", "WBGene00006713", "WBGene00006713", "Q9BL11", "WBGene00021685", "O01965", "WBGene00016158", "P91057", "WBGene00015842", "D0VWL6", "WBGene00016006", "U4PBJ9", "WBGene00022048", "Q9BL11", "WBGene00021685", "O01965", "WBGene00016158", "P91057", "WBGene00015842", "Q21633", "WBGene00006713" ] }, "reaction_10531975": { "compartment": "compartment_70101", "id": "reaction_10531975", "reactome": "R-CEL-1169399", "name": "Interaction of ISG15 with NEDD4 and inhibition of Ebola virus budding", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10530876", "species_10529362" ], "products": [ "species_10531973" ], "modifiers": [], "additional_components": [ "WBGene00022358", "WBGene00015842", "P91057", "WBGene00015842", "A0A061ACQ8", "WBGene00022358" ] }, "reaction_10531960": { "compartment": "compartment_70101", "id": "reaction_10531960", "reactome": "R-CEL-1169397", "name": "Activation of ISG15 by UBA7 E1 ligase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10529372", "species_113592", "species_10529362" ], "products": [ "species_111294", "species_10531957", "species_76577" ], "modifiers": [ [ "species_10529372", "catalyst" ] ], "additional_components": [ "WBGene00006699", "WBGene00015842", "P91057", "WBGene00015842", "Q27481", "WBGene00006699", "WBGene00006699" ] }, "reaction_10531992": { "compartment": "compartment_70101", "id": "reaction_10531992", "reactome": "R-CEL-1169405", "name": "ISGylation of protein phosphatase 1 beta (PP2CB)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10531988", "species_10531955" ], "products": [ "species_111294", "species_10529367", "species_10531990", "species_10531953", "species_76577" ], "modifiers": [ [ "species_10531955", "catalyst" ] ], "additional_components": [ "WBGene00006460", "Q9BL11", "WBGene00021685", "O01965", "WBGene00016158", "P91057", "WBGene00015842", "Q21633", "WBGene00006713", "WBGene00006713", "P91057", "WBGene00015842", "Q19775", "WBGene00006460", "Q9BL11", "WBGene00021685", "O01965", "WBGene00016158", "Q9BL11", "WBGene00021685", "O01965", "WBGene00016158", "P91057", "WBGene00015842", "Q21633", "WBGene00006713" ] }, "reaction_10532011": { "compartment": "compartment_70101", "id": "reaction_10532011", "reactome": "R-CEL-1169406", "name": "ISGylation of host proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10532007", "species_10531955" ], "products": [ "species_111294", "species_10532009", "species_10529367", "species_10531953", "species_76577" ], "modifiers": [ [ "species_10531955", "catalyst" ] ], "additional_components": [ "P39745", "WBGene00003401", "H8W3X5", "WBGene00219376", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q22070", "WBGene00004038", "Q9BL11", "WBGene00021685", "O01965", "WBGene00016158", "P91057", "WBGene00015842", "Q21633", "WBGene00006713", "P91057", "WBGene00015842", "P39745", "WBGene00003401", "H8W3X5", "WBGene00219376", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q22070", "WBGene00004038", "WBGene00006713", "Q9BL11", "WBGene00021685", "O01965", "WBGene00016158", "Q9BL11", "WBGene00021685", "O01965", "WBGene00016158", "P91057", "WBGene00015842", "Q21633", "WBGene00006713" ] }, "reaction_10531981": { "compartment": "compartment_70101", "id": "reaction_10531981", "reactome": "R-CEL-1169402", "name": "ISGylation of E2 conjugating enzymes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10531977", "species_10531955" ], "products": [ "species_111294", "species_10531979", "species_10529367", "species_10531953", "species_76577" ], "modifiers": [ [ "species_10531955", "catalyst" ] ], "additional_components": [ "Q95XX0", "WBGene00006708", "H8W3X5", "WBGene00219376", "Q9BL11", "WBGene00021685", "O01965", "WBGene00016158", "P91057", "WBGene00015842", "Q21633", "WBGene00006713", "P91057", "WBGene00015842", "Q95XX0", "WBGene00006708", "H8W3X5", "WBGene00219376", "WBGene00006713", "Q9BL11", "WBGene00021685", "O01965", "WBGene00016158", "Q9BL11", "WBGene00021685", "O01965", "WBGene00016158", "P91057", "WBGene00015842", "Q21633", "WBGene00006713" ] }, "reaction_10537406": { "compartment": "compartment_70101", "id": "reaction_10537406", "reactome": "R-CEL-1678841", "name": "Regulation of protein ISGylation by ISG15 deconjugating enzyme USP18", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10532009" ], "products": [ "species_10532007", "species_141681" ], "modifiers": [ [ "species_10537403", "catalyst" ] ], "additional_components": [ "P91057", "WBGene00015842", "P39745", "WBGene00003401", "H8W3X5", "WBGene00219376", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q22070", "WBGene00004038", "P39745", "WBGene00003401", "H8W3X5", "WBGene00219376", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q22070", "WBGene00004038", "H2L010", "WBGene00020695" ] }, "reaction_10531983": { "compartment": "compartment_70101", "id": "reaction_10531983", "reactome": "R-CEL-1169403", "name": "Interaction of E3 ligase with ISG15:E2 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10531946", "species_10531953" ], "products": [ "species_10531955" ], "modifiers": [], "additional_components": [ "P91057", "WBGene00015842", "Q21633", "WBGene00006713", "Q9BL11", "WBGene00021685", "O01965", "WBGene00016158", "Q9BL11", "WBGene00021685", "O01965", "WBGene00016158", "P91057", "WBGene00015842", "Q21633", "WBGene00006713" ] }, "reaction_10537423": { "compartment": "compartment_70101", "id": "reaction_10537423", "reactome": "R-CEL-1678842", "name": "Competitive inhibition of translation initiation by ISGylated 4EHP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10537419", "species_10537413" ], "products": [ "species_10537421", "species_10537417" ], "modifiers": [], "additional_components": [ "Q20935", "WBGene00018997", "P27639", "WBGene00002083", "Q9BL61", "WBGene00022029", "A0A486WX07", "WBGene00002066", "O61955", "WBGene00002061", "Q22888", "WBGene00002062", "Q9BL11", "WBGene00021685", "O01965", "WBGene00016158", "P91057", "WBGene00015842", "Q21633", "WBGene00006713", "Q22888", "WBGene00002062", "Q9BL11", "WBGene00021685", "O01965", "WBGene00016158", "P91057", "WBGene00015842", "Q21633", "WBGene00006713", "Q20935", "WBGene00018997", "P27639", "WBGene00002083", "Q9BL61", "WBGene00022029", "A0A486WX07", "WBGene00002066", "O61955", "WBGene00002061" ] }, "reaction_10570813": { "compartment": "compartment_70101", "id": "reaction_10570813", "reactome": "R-CEL-9009950", "name": "PDE12 cleaves 2'-5' oligoadenylates ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_8983696" ], "products": [ "species_70106", "species_113592", "species_76577" ], "modifiers": [ [ "species_10570810", "catalyst" ] ], "additional_components": [ "species_29358", "WBGene00011268" ] }, "reaction_10528100": { "compartment": "compartment_7660", "id": "reaction_10528100", "reactome": "R-CEL-877281", "name": "PIAS1 binds p-STAT1 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10528077", "species_10528091", "species_10528096" ], "products": [ "species_10528098" ], "modifiers": [], "additional_components": [ "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q21970", "WBGene00011259", "Q94361", "WBGene00001574", "WBGene00004888", "P55853", "WBGene00004888", "Q21970", "WBGene00011259", "Q94361", "WBGene00001574", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111" ] }, "reaction_10528079": { "compartment": "compartment_13231", "id": "reaction_10528079", "reactome": "R-CEL-873917", "name": "Translocation of STAT1 dimer to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10528069" ], "products": [ "species_10528077" ], "modifiers": [], "additional_components": [ "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111" ] }, "reaction_10554345": { "compartment": "compartment_876", "id": "reaction_10554345", "reactome": "R-CEL-5654511", "name": "FGFRL1 dimer binds FGFs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10554341", "species_10554339", "species_190915" ], "products": [ "species_10554343" ], "modifiers": [], "additional_components": [ "G5EEF1", "WBGene00001185", "Q95XJ7", "WBGene00022418", "species_190915", "Q95XJ7", "WBGene00022418", "G5EEF1", "WBGene00001185" ] }, "reaction_10554354": { "compartment": "compartment_984", "id": "reaction_10554354", "reactome": "R-CEL-5654515", "name": "KAL1 binds HS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10554350", "species_190915" ], "products": [ "species_10554352" ], "modifiers": [], "additional_components": [ "WBGene00002181", "species_190915", "G5EDX1", "WBGene00002181" ] }, "reaction_10554370": { "compartment": "compartment_70101", "id": "reaction_10554370", "reactome": "R-CEL-5654690", "name": "FGFR1-associated PI3K phosphorylates PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10543825", "catalyst" ] ], "additional_components": [ "Q94125", "WBGene00000090", "G5EDP9", "WBGene00000001", "P29355", "WBGene00004774", "G5EDJ4", "WBGene00004928", "E6N0V1", "WBGene00018819" ] }, "reaction_10512173": { "compartment": "compartment_70101", "id": "reaction_10512173", "reactome": "R-CEL-177931", "name": "Binding of PIK3 regulatory alpha subunit to GRB2:GAB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10512121", "species_10506883" ], "products": [ "species_10512171" ], "modifiers": [], "additional_components": [ "P29355", "WBGene00004774", "G5EDJ4", "WBGene00004928", "WBGene00000001", "G5EDP9", "WBGene00000001", "P29355", "WBGene00004774", "G5EDJ4", "WBGene00004928" ] }, "reaction_10554373": { "compartment": "compartment_70101", "id": "reaction_10554373", "reactome": "R-CEL-5654697", "name": "FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10543855", "catalyst" ] ], "additional_components": [ "Q94125", "WBGene00000090", "G5EDP9", "WBGene00000001", "P29355", "WBGene00004774", "G5EDJ4", "WBGene00004928", "E6N0V1", "WBGene00018819" ] }, "reaction_10554358": { "compartment": "compartment_70101", "id": "reaction_10554358", "reactome": "R-CEL-5654614", "name": "Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10506890", "species_10543831" ], "products": [ "species_10543833" ], "modifiers": [], "additional_components": [ "WBGene00000090", "E6N0V1", "WBGene00018819", "G5EDP9", "WBGene00000001", "P29355", "WBGene00004774", "G5EDJ4", "WBGene00004928", "E6N0V1", "WBGene00018819", "G5EDP9", "WBGene00000001", "P29355", "WBGene00004774", "G5EDJ4", "WBGene00004928", "Q94125", "WBGene00000090" ] }, "reaction_10554376": { "compartment": "compartment_70101", "id": "reaction_10554376", "reactome": "R-CEL-5654701", "name": "FGFR2-associated PI3K phosphorylates PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10543833", "catalyst" ] ], "additional_components": [ "E6N0V1", "WBGene00018819", "G5EDP9", "WBGene00000001", "P29355", "WBGene00004774", "G5EDJ4", "WBGene00004928", "Q94125", "WBGene00000090" ] }, "reaction_10554365": { "compartment": "compartment_70101", "id": "reaction_10554365", "reactome": "R-CEL-5654618", "name": "Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10512175", "species_29438" ], "products": [ "species_29420", "species_10511481" ], "modifiers": [ [ "species_10554362", "catalyst" ] ], "additional_components": [ "species_29420", "P22981", "WBGene00002335", "species_29438", "P22981", "WBGene00002335", "P29355", "WBGene00004774", "Q9N5D3", "WBGene00004947" ] }, "reaction_10562965": { "compartment": "compartment_7660", "id": "reaction_10562965", "reactome": "R-CEL-6803523", "name": "PTB and hnRNPA1 bind FGFR2 pre-mRNA to repress IIIb splicing and promote formation of FGFR2c mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10504458", "species_10504465", "species_10562961" ], "products": [ "species_10562963" ], "modifiers": [], "additional_components": [ "WBGene00004207", "WBGene00019881", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "P34541", "WBGene00019881", "Q18999", "WBGene00004207" ] }, "reaction_10554385": { "compartment": "compartment_70101", "id": "reaction_10554385", "reactome": "R-CEL-5654717", "name": "FGFR4-associated PI3K phosphorylates PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10543849", "catalyst" ] ], "additional_components": [ "E6N0V1", "WBGene00018819", "G5EDP9", "WBGene00000001", "P29355", "WBGene00004774", "G5EDJ4", "WBGene00004928", "Q94125", "WBGene00000090" ] }, "reaction_10554332": { "compartment": "compartment_70101", "id": "reaction_10554332", "reactome": "R-CEL-5654413", "name": "Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10512175", "species_29438" ], "products": [ "species_29420", "species_10511481" ], "modifiers": [ [ "species_10554329", "catalyst" ] ], "additional_components": [ "species_29420", "P22981", "WBGene00002335", "species_29438", "P22981", "WBGene00002335", "P29355", "WBGene00004774", "Q9N5D3", "WBGene00004947" ] }, "reaction_10554379": { "compartment": "compartment_70101", "id": "reaction_10554379", "reactome": "R-CEL-5654705", "name": "FGFR3-associated PI3K phosphorylates PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10543841", "catalyst" ] ], "additional_components": [ "Q94125", "WBGene00000090", "G5EDP9", "WBGene00000001", "P29355", "WBGene00004774", "G5EDJ4", "WBGene00004928", "E6N0V1", "WBGene00018819" ] }, "reaction_10554367": { "compartment": "compartment_70101", "id": "reaction_10554367", "reactome": "R-CEL-5654640", "name": "Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10543839", "species_10506890" ], "products": [ "species_10543841" ], "modifiers": [], "additional_components": [ "G5EDP9", "WBGene00000001", "P29355", "WBGene00004774", "G5EDJ4", "WBGene00004928", "E6N0V1", "WBGene00018819", "WBGene00000090", "Q94125", "WBGene00000090", "G5EDP9", "WBGene00000001", "P29355", "WBGene00004774", "G5EDJ4", "WBGene00004928", "E6N0V1", "WBGene00018819" ] }, "reaction_10554382": { "compartment": "compartment_70101", "id": "reaction_10554382", "reactome": "R-CEL-5654709", "name": "FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10543861", "catalyst" ] ], "additional_components": [ "E6N0V1", "WBGene00018819", "G5EDP9", "WBGene00000001", "P29355", "WBGene00004774", "G5EDJ4", "WBGene00004928", "Q94125", "WBGene00000090" ] }, "reaction_10546375": { "compartment": "compartment_70101", "id": "reaction_10546375", "reactome": "R-CEL-3134914", "name": "Beta-catenin migrates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546373" ], "products": [ "species_10546371" ], "modifiers": [], "additional_components": [ "WBGene00001979", "WBGene00001979" ] }, "reaction_10536514": { "compartment": "compartment_70101", "id": "reaction_10536514", "reactome": "R-CEL-1614567", "name": "Excess homocysteine yields homolanthionine and H2S", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_174369" ], "products": [ "species_1614532", "species_1614594" ], "modifiers": [ [ "species_10536511", "catalyst" ], [ "species_174369", "catalyst" ] ], "additional_components": [ "P55216", "WBGene00022856" ] }, "reaction_10571811": { "compartment": "compartment_5460", "id": "reaction_10571811", "reactome": "R-CEL-9034756", "name": "MPST transfers sulfur atom from 3MPYR to form CysS248-MPST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9012592", "species_10570931" ], "products": [ "species_113557", "species_10571809" ], "modifiers": [ [ "species_10570931", "catalyst" ] ], "additional_components": [ "WBGene00022006", "WBGene00022006", "WBGene00022006" ] }, "reaction_10571815": { "compartment": "compartment_5460", "id": "reaction_10571815", "reactome": "R-CEL-9035227", "name": "TXN2 binds CysS248-MPST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10547396", "species_10571809" ], "products": [ "species_10571813" ], "modifiers": [], "additional_components": [ "WBGene00007099", "WBGene00022006", "G5ECA0", "WBGene00022006", "Q17424", "WBGene00007099" ] }, "reaction_10536520": { "compartment": "compartment_70101", "id": "reaction_10536520", "reactome": "R-CEL-1614591", "name": "Excess cysteine yields lanthionine and H2S", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111707" ], "products": [ "species_1614582", "species_1614532" ], "modifiers": [ [ "species_10536511", "catalyst" ], [ "species_111707", "catalyst" ] ], "additional_components": [ "P55216", "WBGene00022856" ] }, "reaction_10571817": { "compartment": "compartment_5460", "id": "reaction_10571817", "reactome": "R-CEL-9035484", "name": "CysS248-MPST:TXN2 dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10571813" ], "products": [ "species_10547399", "species_10570931", "species_1655881" ], "modifiers": [], "additional_components": [ "G5ECA0", "WBGene00022006", "Q17424", "WBGene00007099", "WBGene00007099", "WBGene00022006" ] }, "reaction_10536553": { "compartment": "compartment_70101", "id": "reaction_10536553", "reactome": "R-CEL-1614645", "name": "CDO1:Fe2+ oxidises L-Cys to 3-Sulfinoalanine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111707", "species_29368" ], "products": [ "species_1614519" ], "modifiers": [ [ "species_10536550", "catalyst" ] ], "additional_components": [ "Q20893", "WBGene00018986", "species_113531" ] }, "reaction_10536501": { "compartment": "compartment_5460", "id": "reaction_10536501", "reactome": "R-CEL-1614544", "name": "Sulfite is oxidized to sulfate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113533", "species_1614538", "species_113521" ], "products": [ "species_1614617", "species_1614584" ], "modifiers": [ [ "species_10536498", "catalyst" ] ], "additional_components": [ "Q9XTQ8", "WBGene00010397", "species_947539" ] }, "reaction_10536503": { "compartment": "compartment_70616", "id": "reaction_10536503", "reactome": "R-CEL-1614546", "name": "Sulfate is exported to the cytosol in exchange for dicarboxylate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_198498", "species_1614584" ], "products": [ "species_113544", "species_174375" ], "modifiers": [ [ "species_10518419", "catalyst" ] ], "additional_components": [ "WBGene00019656" ] }, "reaction_10536538": { "compartment": "compartment_70616", "id": "reaction_10536538", "reactome": "R-CEL-1614605", "name": "Persulfide sulfur is dioxygenated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10536526", "species_113533", "species_113521" ], "products": [ "species_113529", "species_1614538", "species_10536528" ], "modifiers": [ [ "species_10536535", "catalyst" ] ], "additional_components": [ "WBGene00008538", "WBGene00008538", "O17636", "WBGene00007886", "species_216785" ] }, "reaction_10571219": { "compartment": "compartment_5460", "id": "reaction_10571219", "reactome": "R-CEL-9013471", "name": "MPST transfers sulfur from 3MPYR to HCN to form HSCN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9012592", "species_9013199" ], "products": [ "species_9013191", "species_113557" ], "modifiers": [ [ "species_10570931", "catalyst" ] ], "additional_components": [ "WBGene00022006" ] }, "reaction_10571186": { "compartment": "compartment_5460", "id": "reaction_10571186", "reactome": "R-CEL-9013198", "name": "TST transfers sulfur from S2O3(2-) to HCN to form HSCN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1614595", "species_9013199" ], "products": [ "species_9013207", "species_9013191" ], "modifiers": [ [ "species_10571183", "catalyst" ] ], "additional_components": [ "G5ECA0", "WBGene00022006", "O17730", "WBGene00008409", "G5EEV0", "WBGene00011307", "P91247", "WBGene00017387", "Q9XTX2", "WBGene00010380", "H9G340", "WBGene00010383" ] }, "reaction_10571221": { "compartment": "compartment_5460", "id": "reaction_10571221", "reactome": "R-CEL-9013533", "name": "MPST transfers sulfur from sulfanegen to HCN to form HSCN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9013543", "species_9013199" ], "products": [ "species_9013191", "species_113557" ], "modifiers": [ [ "species_10570931", "catalyst" ] ], "additional_components": [ "WBGene00022006" ] }, "reaction_10564244": { "compartment": "compartment_70101", "id": "reaction_10564244", "reactome": "R-CEL-6814153", "name": "ADO oxidises 2AET to HTAU", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_6814151" ], "products": [ "species_1655445", "species_70106" ], "modifiers": [ [ "species_10564241", "catalyst" ] ], "additional_components": [ "species_113531", "Q8IAA1", "WBGene00021750" ] }, "reaction_10570934": { "compartment": "compartment_5460", "id": "reaction_10570934", "reactome": "R-CEL-9012721", "name": "MPST transfers sulfur atom from 3MPYR to HSO3- to form S2O3(2-) and PYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9012724", "species_9012592" ], "products": [ "species_1614595", "species_113557" ], "modifiers": [ [ "species_10570931", "catalyst" ] ], "additional_components": [ "WBGene00022006" ] }, "reaction_10536540": { "compartment": "compartment_70101", "id": "reaction_10536540", "reactome": "R-CEL-1614614", "name": "Cysteine is degraded to serine and H2S", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_111707" ], "products": [ "species_1614532", "species_200736" ], "modifiers": [ [ "species_10536511", "catalyst" ] ], "additional_components": [ "P55216", "WBGene00022856" ] }, "reaction_10536543": { "compartment": "compartment_70101", "id": "reaction_10536543", "reactome": "R-CEL-1614631", "name": "Homocysteine is degraded to oxobutanoate and H2S", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_174369" ], "products": [ "species_1614532", "species_29382", "species_936714" ], "modifiers": [ [ "species_10536511", "catalyst" ] ], "additional_components": [ "P55216", "WBGene00022856" ] }, "reaction_10507392": { "compartment": "compartment_70101", "id": "reaction_10507392", "reactome": "R-CEL-75849", "name": "Transport of Citrate from Mitochondrial Matrix to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29654", "species_198498" ], "products": [ "species_76190", "species_113544" ], "modifiers": [ [ "species_10507389", "catalyst" ] ], "additional_components": [ "WBGene00010780" ] }, "reaction_10556609": { "compartment": "compartment_161320", "id": "reaction_10556609", "reactome": "R-CEL-5690517", "name": "PPT1 hydrolyses palmitoylated proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_5690533" ], "products": [ "species_6785219", "species_5690516" ], "modifiers": [ [ "species_10556606", "catalyst" ] ], "additional_components": [ "species_390435", "species_6785219", "WBGene00004092" ] }, "reaction_10527328": { "compartment": "compartment_70101", "id": "reaction_10527328", "reactome": "R-CEL-548843", "name": "ACSL3,4 ligate CoA to AA to form AA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_29768", "species_76194" ], "products": [ "species_111294", "species_29356", "species_548819", "species_76577" ], "modifiers": [ [ "species_10527325", "catalyst" ] ], "additional_components": [ "A0A4V0ING4", "WBGene00016716" ] }, "reaction_10527264": { "compartment": "compartment_70101", "id": "reaction_10527264", "reactome": "R-CEL-548800", "name": "ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_548819", "species_29508" ], "products": [ "species_113528", "species_548816", "species_76194" ], "modifiers": [ [ "species_10527261", "catalyst" ] ], "additional_components": [ "WBGene00001241" ] }, "reaction_10555303": { "compartment": "compartment_12045", "id": "reaction_10555303", "reactome": "R-CEL-5676637", "name": "PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5676631" ], "products": [ "species_29356", "species_5676634" ], "modifiers": [ [ "species_10555300", "catalyst" ] ], "additional_components": [ "O17040", "WBGene00020517" ] }, "reaction_10527321": { "compartment": "compartment_70101", "id": "reaction_10527321", "reactome": "R-CEL-548831", "name": "TECR,TECRL dehydrogenate TOD-CoA to ST-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_548809" ], "products": [ "species_428139", "species_29366" ], "modifiers": [ [ "species_10527316", "catalyst" ] ], "additional_components": [ "WBGene00000198" ] }, "reaction_10527308": { "compartment": "compartment_70101", "id": "reaction_10527308", "reactome": "R-CEL-548814", "name": "ELOVL3,6,7 elongate PALM-CoA and Mal-CoA to 3OOD-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29508", "species_200993" ], "products": [ "species_113528", "species_548812", "species_76194" ], "modifiers": [ [ "species_10527305", "catalyst" ] ], "additional_components": [ "Q9NAC6", "WBGene00001247", "Q20300", "WBGene00001243", "G5EEE5", "WBGene00001239", "Q9XVQ9", "WBGene00001240", "Q20303", "WBGene00001244", "P49191", "WBGene00001241", "Q20904", "WBGene00001245", "Q03574", "WBGene00001242" ] }, "reaction_10514751": { "compartment": "compartment_70101", "id": "reaction_10514751", "reactome": "R-CEL-201035", "name": "ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_3632881", "species_76194" ], "products": [ "species_111294", "species_29356", "species_200993", "species_76577" ], "modifiers": [ [ "species_10514748", "catalyst" ] ], "additional_components": [ "Q9XWD1", "WBGene00013575", "O16775", "WBGene00019920", "V6CLI5", "WBGene00022037", "O44560", "WBGene00020343", "Q21872", "WBGene00011173", "A0A4V0ING4", "WBGene00016716", "Q20121", "WBGene00018152" ] }, "reaction_10527311": { "compartment": "compartment_70101", "id": "reaction_10527311", "reactome": "R-CEL-548818", "name": "HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_548812" ], "products": [ "species_548836", "species_29366" ], "modifiers": [ [ "species_10513362", "catalyst" ] ], "additional_components": [ "WBGene00000969" ] }, "reaction_10507383": { "compartment": "compartment_70101", "id": "reaction_10507383", "reactome": "R-CEL-75848", "name": "ACLY tetramer transforms CIT to Ac-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76190", "species_113592", "species_76194" ], "products": [ "species_29372", "species_29370", "species_76183", "species_76213" ], "modifiers": [ [ "species_10507375", "catalyst" ], [ "species_10507381", "catalyst" ] ], "additional_components": [ "P53585", "WBGene00016995", "WBGene00022531" ] }, "reaction_10514618": { "compartment": "compartment_70101", "id": "reaction_10514618", "reactome": "R-CEL-200555", "name": "acetyl-CoA + bicarbonate + ATP => malonyl-CoA + H2O + ADP + orthophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111627", "species_113592", "species_76183" ], "products": [ "species_29372", "species_29370", "species_29508" ], "modifiers": [ [ "species_10507411", "catalyst" ], [ "species_76190", "catalyst" ] ], "additional_components": [ "Q9XUC3", "WBGene00012131", "H2L0M0", "WBGene00004076" ] }, "reaction_10556619": { "compartment": "compartment_12045", "id": "reaction_10556619", "reactome": "R-CEL-5690565", "name": "SCD desaturates ST-CoA to OLE-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428139", "species_70106", "species_4085415", "species_29368" ], "products": [ "species_4085425", "species_29356", "species_5690558" ], "modifiers": [ [ "species_10556616", "catalyst" ] ], "additional_components": [ "G5EGN2", "WBGene00001398" ] }, "reaction_10510254": { "compartment": "compartment_70101", "id": "reaction_10510254", "reactome": "R-CEL-163756", "name": "Formation of fatty acid synthase (FAS) dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10507450" ], "products": [ "species_10507452" ], "modifiers": [], "additional_components": [ "WBGene00009342", "P91871", "WBGene00009342" ] }, "reaction_10507455": { "compartment": "compartment_70101", "id": "reaction_10507455", "reactome": "R-CEL-75872", "name": "acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_76183", "species_29364", "species_29508" ], "products": [ "species_29356", "species_113528", "species_29366", "species_3632881", "species_76194" ], "modifiers": [ [ "species_10507452", "catalyst" ] ], "additional_components": [ "P91871", "WBGene00009342" ] }, "reaction_10564542": { "compartment": "compartment_12045", "id": "reaction_10564542", "reactome": "R-CEL-8847579", "name": "SCD5 desaturates ST-CoA to OLE-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428139", "species_70106", "species_4085415", "species_29368" ], "products": [ "species_4085425", "species_29356", "species_5690558" ], "modifiers": [ [ "species_10564539", "catalyst" ] ], "additional_components": [ "G5ED44", "WBGene00001397", "G5EGH6", "WBGene00001399", "G5EGN2", "WBGene00001398" ] }, "reaction_10571480": { "compartment": "compartment_70101", "id": "reaction_10571480", "reactome": "R-CEL-9018877", "name": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(R)-HEPE to 18(R)-RvE1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_9023708" ], "products": [ "species_9023712" ], "modifiers": [ [ "species_10517863", "catalyst" ] ], "additional_components": [ "species_216785", "G5EFT4", "WBGene00016589" ] }, "reaction_10571482": { "compartment": "compartment_70101", "id": "reaction_10571482", "reactome": "R-CEL-9018895", "name": "GPX4-2 reduces 18(R)-HpEPE to 18(R)-HEPE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9023653", "species_29450" ], "products": [ "species_29356", "species_9023651", "species_111745" ], "modifiers": [ [ "species_10571475", "catalyst" ] ], "additional_components": [ "WBGene00019846" ] }, "reaction_10569921": { "compartment": "compartment_17947", "id": "reaction_10569921", "reactome": "R-CEL-8953946", "name": "PEX2:PEX10:PEX12 monoubiquitinates PEX5S,L at cysteine-11", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10569909" ], "products": [ "species_10569918", "species_10532186" ], "modifiers": [ [ "species_10569909", "catalyst" ] ], "additional_components": [ "P35129", "WBGene00002344", "P91853", "WBGene00006732", "Q17720", "WBGene00006717", "Q20617", "WBGene00006719", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "Q19951", "WBGene00004198", "Q93930", "WBGene00004199", "Q18355", "WBGene00016318", "Q19189", "WBGene00004197", "Q18426", "WBGene00004194", "Q19951", "WBGene00004198", "Q93930", "WBGene00004199", "Q18355", "WBGene00016318", "Q19189", "WBGene00004197", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "Q18426", "WBGene00004194", "P35129", "WBGene00002344", "P91853", "WBGene00006732", "Q17720", "WBGene00006717", "Q20617", "WBGene00006719", "P35129", "WBGene00002344", "P91853", "WBGene00006732", "Q17720", "WBGene00006717", "Q20617", "WBGene00006719", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "Q19951", "WBGene00004198", "Q93930", "WBGene00004199", "Q18355", "WBGene00016318", "Q19189", "WBGene00004197", "Q18426", "WBGene00004194" ] }, "reaction_10569911": { "compartment": "compartment_17947", "id": "reaction_10569911", "reactome": "R-CEL-8953917", "name": "PEX2:PEX10:PEX12 binds PEX5S,L (in PEX5S:PEX13:PEX14) and Ub:UBE2D1,2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10569900", "species_10569907" ], "products": [ "species_10569909" ], "modifiers": [], "additional_components": [ "Q19951", "WBGene00004198", "Q93930", "WBGene00004199", "Q18355", "WBGene00016318", "Q19189", "WBGene00004197", "Q18426", "WBGene00004194", "P35129", "WBGene00002344", "P91853", "WBGene00006732", "Q17720", "WBGene00006717", "Q20617", "WBGene00006719", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "P35129", "WBGene00002344", "P91853", "WBGene00006732", "Q17720", "WBGene00006717", "Q20617", "WBGene00006719", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "Q19951", "WBGene00004198", "Q93930", "WBGene00004199", "Q18355", "WBGene00016318", "Q19189", "WBGene00004197", "Q18426", "WBGene00004194" ] }, "reaction_10568412": { "compartment": "compartment_70101", "id": "reaction_10568412", "reactome": "R-CEL-8938815", "name": "RNF152 polyubiquitinates RRAGA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10568399", "species_10568401" ], "products": [ "species_10568392", "species_10568409", "species_10515250" ], "modifiers": [ [ "species_10568401", "catalyst" ] ], "additional_components": [ "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "Q95XX0", "WBGene00006708", "Q19214", "WBGene00008588", "species_29420", "Q22743", "WBGene00006414", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "Q95XX0", "WBGene00006708", "WBGene00008588", "Q22743", "WBGene00006414", "species_29420", "WBGene00006708", "Q19214", "WBGene00008588", "species_29420", "Q22743", "WBGene00006414", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "Q95XX0", "WBGene00006708" ] }, "reaction_10568414": { "compartment": "compartment_70101", "id": "reaction_10568414", "reactome": "R-CEL-8938829", "name": "RNF152 binds RRAGA:GDP and Ubiquitin:UBE2D3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10568399", "species_10568394", "species_10568392" ], "products": [ "species_10568401" ], "modifiers": [], "additional_components": [ "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "Q95XX0", "WBGene00006708", "species_29420", "Q22743", "WBGene00006414", "WBGene00008588", "Q19214", "WBGene00008588", "species_29420", "Q22743", "WBGene00006414", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "Q95XX0", "WBGene00006708" ] }, "reaction_10551718": { "compartment": "compartment_12045", "id": "reaction_10551718", "reactome": "R-CEL-5362412", "name": "SYVN1 ubiquitinates Hh C-terminal fragments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10551711", "species_10502375" ], "products": [ "species_10551715" ], "modifiers": [ [ "species_10551711", "catalyst" ] ], "additional_components": [ "Q09396", "WBGene00018611", "Q9NF22", "WBGene00013667", "G5EFG0", "WBGene00004759", "Q21997", "WBGene00020109", "P54812", "WBGene00008053", "Q20798", "WBGene00004768", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "Q09396", "WBGene00018611", "Q9NF22", "WBGene00013667", "G5EFG0", "WBGene00004759", "Q21997", "WBGene00020109", "P54812", "WBGene00008053", "Q20798", "WBGene00004768", "Q09396", "WBGene00018611", "Q9NF22", "WBGene00013667", "G5EFG0", "WBGene00004759", "Q21997", "WBGene00020109", "P54812", "WBGene00008053", "Q20798", "WBGene00004768" ] }, "reaction_10552665": { "compartment": "compartment_876", "id": "reaction_10552665", "reactome": "R-CEL-5610727", "name": "GPR161 promotes cAMP production in a G alpha(s)-dependent manner", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592" ], "products": [ "species_111294", "species_30389" ], "modifiers": [ [ "species_10552658", "catalyst" ], [ "species_10552663", "catalyst" ] ], "additional_components": [ "species_114632", "Q09306", "WBGene00006655", "Q20255", "WBGene00022696", "Q18859", "WBGene00016935", "G5EFW7", "WBGene00000906", "G5ECZ4", "WBGene00001118", "P90757", "WBGene00000490" ] }, "reaction_10552670": { "compartment": "compartment_70101", "id": "reaction_10552670", "reactome": "R-CEL-5610735", "name": "NUMB binds ITCH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10524550", "species_10530869" ], "products": [ "species_10552668" ], "modifiers": [], "additional_components": [ "WBGene00003830", "WBGene00007009", "Q9N2Z7", "WBGene00007009", "Q9XTY6", "WBGene00003830" ] }, "reaction_10552682": { "compartment": "compartment_5263232", "id": "reaction_10552682", "reactome": "R-CEL-5610749", "name": "cAMP dissociates PKA, promoting GLI processing", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10552678", "species_30389" ], "products": [ "species_10552680", "species_10552672" ], "modifiers": [], "additional_components": [ "P21137", "WBGene00002189", "P30625", "WBGene00002190", "P30625", "WBGene00002190", "species_30389", "WBGene00002189" ] }, "reaction_10552654": { "compartment": "compartment_18730", "id": "reaction_10552654", "reactome": "R-CEL-5610726", "name": "The IFT-A complex recruits TULP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10552650", "species_10552619" ], "products": [ "species_10552652" ], "modifiers": [], "additional_components": [ "Q20255", "WBGene00022696", "Q18859", "WBGene00016935", "G5EFW7", "WBGene00000906", "G5ECZ4", "WBGene00001118", "P90757", "WBGene00000490", "WBGene00006655", "Q09306", "WBGene00006655", "Q20255", "WBGene00022696", "Q18859", "WBGene00016935", "G5EFW7", "WBGene00000906", "G5ECZ4", "WBGene00001118", "P90757", "WBGene00000490" ] }, "reaction_10554098": { "compartment": "compartment_7660", "id": "reaction_10554098", "reactome": "R-CEL-5635854", "name": "GLI2,3 are degraded by the proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10554096" ], "products": [ "species_10554094", "species_10502318" ], "modifiers": [ [ "species_10512606", "catalyst" ] ], "additional_components": [ "Q23457", "WBGene00004320", "P34568", "WBGene00011815", "Q9NF14", "WBGene00013689", "H2KYJ3", "WBGene00015567", "P41886", "WBGene00018137", "Q94420", "WBGene00003209", "P34371", "WBGene00016803", "Q17391", "WBGene00000838", "Q23457", "WBGene00004320", "P34568", "WBGene00011815", "Q9NF14", "WBGene00013689", "H2KYJ3", "WBGene00015567", "P41886", "WBGene00018137", "Q94420", "WBGene00003209", "P34371", "WBGene00016803", "Q17391", "WBGene00000838", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "Q23237", "WBGene00003949", "P90868", "WBGene00003953", "Q9XUV0", "WBGene00003951", "Q966I8", "WBGene00003947", "O62102", "WBGene00003948", "O16368", "WBGene00004502", "Q18787", "WBGene00004501", "O76371", "WBGene00004505", "P46502", "WBGene00004503", "Q9XTT9", "WBGene00004506", "O17071", "WBGene00004504", "Q18115", "WBGene00004459", "Q20938", "WBGene00004462", "Q19324", "WBGene00004461", "Q22253", "WBGene00004465", "Q9GZH5", "WBGene00004458", "Q04908", "WBGene00004460", "O61742", "WBGene00004466", "O76577", "WBGene00004467", "Q20058", "WBGene00009445", "O44156", "WBGene00003927", "Q20585", "WBGene00004463", "Q27488", "WBGene00003923", "O61792", "WBGene00004464", "Q09583", "WBGene00003928", "Q23449", "WBGene00004468", "Q9N599", "WBGene00003924", "Q10920", "WBGene00016623", "Q95008", "WBGene00003926", "Q95PZ7", "WBGene00013435", "O17586", "WBGene00003922", "Q95005", "WBGene00003925", "P34286", "WBGene00003952", "P91477", "WBGene00003950" ] }, "reaction_10554020": { "compartment": "compartment_261122", "id": "reaction_10554020", "reactome": "R-CEL-5632677", "name": "PTCH is internalized", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10554012" ], "products": [ "species_10554018" ], "modifiers": [], "additional_components": [ "H2L0G5", "WBGene00004210", "Q09614", "WBGene00004208", "Q09614", "WBGene00004208", "H2L0G5", "WBGene00004210" ] }, "reaction_10554105": { "compartment": "compartment_7660", "id": "reaction_10554105", "reactome": "R-CEL-5635856", "name": "SPOP:CUL3:RBX1 ubiquitinates GLI2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502318", "species_10554102" ], "products": [ "species_10554096" ], "modifiers": [ [ "species_10554102", "catalyst" ] ], "additional_components": [ "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "Q23457", "WBGene00004320", "P34568", "WBGene00011815", "Q9NF14", "WBGene00013689", "H2KYJ3", "WBGene00015567", "P41886", "WBGene00018137", "Q94420", "WBGene00003209", "P34371", "WBGene00016803", "Q17391", "WBGene00000838", "Q23457", "WBGene00004320", "P34568", "WBGene00011815", "Q9NF14", "WBGene00013689", "H2KYJ3", "WBGene00015567", "P41886", "WBGene00018137", "Q94420", "WBGene00003209", "P34371", "WBGene00016803", "Q17391", "WBGene00000838", "Q23457", "WBGene00004320", "P34568", "WBGene00011815", "Q9NF14", "WBGene00013689", "H2KYJ3", "WBGene00015567", "P41886", "WBGene00018137", "Q94420", "WBGene00003209", "P34371", "WBGene00016803", "Q17391", "WBGene00000838" ] }, "reaction_10557600": { "compartment": "compartment_70101", "id": "reaction_10557600", "reactome": "R-CEL-5696230", "name": "GSTO1 dimer reduces methylarsonate to methylarsonite", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29450", "species_5696214" ], "products": [ "species_29356", "species_5696224", "species_111745" ], "modifiers": [ [ "species_10511838", "catalyst" ] ], "additional_components": [ "P34345", "WBGene00016204" ] }, "reaction_10511831": { "compartment": "compartment_70101", "id": "reaction_10511831", "reactome": "R-CEL-175987", "name": "NNMT transfers CH3 from AdoMet to PY", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_175973", "species_71284" ], "products": [ "species_175979", "species_71285" ], "modifiers": [ [ "species_10511828", "catalyst" ] ], "additional_components": [ "WBGene00015124" ] }, "reaction_10511767": { "compartment": "compartment_70101", "id": "reaction_10511767", "reactome": "R-CEL-174374", "name": "MTR transfers CH3 from MeCbl to HCYS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_174369", "species_10511760" ], "products": [ "species_174390", "species_10511764" ], "modifiers": [ [ "species_10511760", "catalyst" ] ], "additional_components": [ "species_73524", "Q17574", "WBGene00006510", "species_113596", "species_216785", "CHEBI:28115", "Q09582", "WBGene00010988", "species_216785", "species_3159260", "Q09582", "WBGene00010988", "species_73524", "Q17574", "WBGene00006510", "species_113596", "species_73524", "Q17574", "WBGene00006510", "species_113596", "species_216785", "CHEBI:28115", "Q09582", "WBGene00010988" ] }, "reaction_10511802": { "compartment": "compartment_70101", "id": "reaction_10511802", "reactome": "R-CEL-174401", "name": "AHCY:NAD+ tetramer hydrolyses AdoHcy", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_71285" ], "products": [ "species_83909", "species_174369" ], "modifiers": [ [ "species_10511799", "catalyst" ] ], "additional_components": [ "species_29360", "P27604", "WBGene00019322" ] }, "reaction_10562143": { "compartment": "compartment_70101", "id": "reaction_10562143", "reactome": "R-CEL-6800149", "name": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to MMAIII", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6806829", "species_71284" ], "products": [ "species_6800127", "species_71285" ], "modifiers": [ [ "species_10562137", "catalyst" ] ], "additional_components": [ "O16582", "WBGene00016341", "O45241", "WBGene00007312" ] }, "reaction_10509986": { "compartment": "compartment_70101", "id": "reaction_10509986", "reactome": "R-CEL-159358", "name": "SULT1A3,4 dimers sulfate DA to DAOS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158471", "species_159362" ], "products": [ "species_159352", "species_158466" ], "modifiers": [ [ "species_10509940", "catalyst" ] ], "additional_components": [ "Q9U2Z2", "WBGene00013748" ] }, "reaction_10511970": { "compartment": "compartment_70101", "id": "reaction_10511970", "reactome": "R-CEL-176517", "name": "SULTs transfer (SO4)2- group to PREG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193103", "species_158471" ], "products": [ "species_176665", "species_158466" ], "modifiers": [ [ "species_10511967", "catalyst" ] ], "additional_components": [ "Q9U2Z2", "WBGene00013748" ] }, "reaction_10512002": { "compartment": "compartment_70101", "id": "reaction_10512002", "reactome": "R-CEL-176631", "name": "dehydroepiandrosterone (DHEA) + PAPS => DHEA sulfate + PAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158471", "species_176626" ], "products": [ "species_176496", "species_158466" ], "modifiers": [ [ "species_10511999", "catalyst" ] ], "additional_components": [ "Q9U2Z2", "WBGene00013748" ] }, "reaction_10511777": { "compartment": "compartment_70101", "id": "reaction_10511777", "reactome": "R-CEL-174389", "name": "PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_174370" ], "products": [ "species_29370", "species_158471" ], "modifiers": [ [ "species_10511772", "catalyst" ] ], "additional_components": [ "WBGene00004091" ] }, "reaction_10522868": { "compartment": "compartment_876", "id": "reaction_10522868", "reactome": "R-CEL-427555", "name": "SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_427648" ], "products": [ "species_70106", "species_174375" ], "modifiers": [ [ "species_10522865", "catalyst" ] ], "additional_components": [ "O17951", "WBGene00010789", "G5EEA7", "WBGene00010788", "O45016", "WBGene00020914", "G5EED0", "WBGene00016945", "Q94225", "WBGene00018283", "G5EFB2", "WBGene00013963", "G5EC30", "WBGene00012259" ] }, "reaction_10511780": { "compartment": "compartment_70101", "id": "reaction_10511780", "reactome": "R-CEL-174392", "name": "PAPSS1,2 transfer SO4(2-) group to ATP to form APS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_174375" ], "products": [ "species_111294", "species_174370" ], "modifiers": [ [ "species_10511772", "catalyst" ] ], "additional_components": [ "WBGene00004091" ] }, "reaction_10527852": { "compartment": "compartment_20699", "id": "reaction_10527852", "reactome": "R-CEL-741449", "name": "SLC35B2,3 transport cytosolic PAPS to Golgi lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158471" ], "products": [ "species_741440" ], "modifiers": [ [ "species_10527849", "catalyst" ] ], "additional_components": [ "Q8MXJ9", "WBGene00004206", "Q20787", "WBGene00018827" ] }, "reaction_10511973": { "compartment": "compartment_70101", "id": "reaction_10511973", "reactome": "R-CEL-176521", "name": "beta-estradiol + PAPS => beta-estradiol 3-sulfate + PAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_176619", "species_158471" ], "products": [ "species_176492", "species_158466" ], "modifiers": [ [ "species_10511945", "catalyst" ] ], "additional_components": [ "Q9U2Z2", "WBGene00013748" ] }, "reaction_10569867": { "compartment": "compartment_17963", "id": "reaction_10569867", "reactome": "R-CEL-8953499", "name": "IMPAD1 hydrolyses PAP to AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_742343", "species_2022884" ], "products": [ "species_8851226", "species_8953493" ], "modifiers": [ [ "species_10569864", "catalyst" ], [ "species_8953505", "inhibitor" ] ], "additional_components": [ "species_114632", "Q5ZEQ3", "WBGene00012390" ] }, "reaction_10512011": { "compartment": "compartment_70101", "id": "reaction_10512011", "reactome": "R-CEL-176646", "name": "p-nitrophenol + PAPS => p-nitrophenol sulfate + PAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5695950", "species_158471" ], "products": [ "species_176600", "species_158466" ], "modifiers": [ [ "species_10512008", "catalyst" ] ], "additional_components": [ "Q9U2Z2", "WBGene00013748" ] }, "reaction_10511982": { "compartment": "compartment_70101", "id": "reaction_10511982", "reactome": "R-CEL-176585", "name": "3,5,3'-triiodothyronine + PAPS => 3,5,3'-triiodothyronine 4-sulfate + PAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_176667", "species_158471" ], "products": [ "species_176564", "species_158466" ], "modifiers": [ [ "species_10511979", "catalyst" ] ], "additional_components": [ "Q9U2Z2", "WBGene00013748" ] }, "reaction_10512016": { "compartment": "compartment_70101", "id": "reaction_10512016", "reactome": "R-CEL-176664", "name": "estrone + PAPS => estrone 3-sulfate + PAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_176575", "species_158471" ], "products": [ "species_176501", "species_158466" ], "modifiers": [ [ "species_10512013", "catalyst" ] ], "additional_components": [ "Q9U2Z2", "WBGene00013748" ] }, "reaction_10511985": { "compartment": "compartment_70101", "id": "reaction_10511985", "reactome": "R-CEL-176588", "name": "lithocholate + PAPS => lithocholate sulfate + PAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_176655", "species_158471" ], "products": [ "species_176555", "species_158466" ], "modifiers": [ [ "species_10511949", "catalyst" ] ], "additional_components": [ "Q9U2Z2", "WBGene00013748" ] }, "reaction_10511987": { "compartment": "compartment_70101", "id": "reaction_10511987", "reactome": "R-CEL-176604", "name": "taurolithocholate + PAPS => taurolithocholate sulfate + PAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_176565", "species_158471" ], "products": [ "species_176483", "species_158466" ], "modifiers": [ [ "species_10511949", "catalyst" ] ], "additional_components": [ "Q9U2Z2", "WBGene00013748" ] }, "reaction_10512021": { "compartment": "compartment_70101", "id": "reaction_10512021", "reactome": "R-CEL-176669", "name": "N-hydroxy-2-acetylaminofluorene + PAPS => 2-acetylaminofluorene-N-sulfate + PAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158471", "species_176566" ], "products": [ "species_176500", "species_158466" ], "modifiers": [ [ "species_10512018", "catalyst" ] ], "additional_components": [ "Q9U2Z2", "WBGene00013748" ] }, "reaction_10511958": { "compartment": "compartment_70101", "id": "reaction_10511958", "reactome": "R-CEL-176474", "name": "3,3'-diiodothyronine + PAPS => 3,3'-diiodothyronine 4-sulfate + PAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158471", "species_176486" ], "products": [ "species_176519", "species_158466" ], "modifiers": [ [ "species_10511955", "catalyst" ] ], "additional_components": [ "Q9U2Z2", "WBGene00013748" ] }, "reaction_10509943": { "compartment": "compartment_70101", "id": "reaction_10509943", "reactome": "R-CEL-158468", "name": "SULT1A1 dimer sulfonates PARA to PARA-SO4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158469", "species_158471" ], "products": [ "species_158472", "species_158466" ], "modifiers": [ [ "species_10509940", "catalyst" ] ], "additional_components": [ "Q9U2Z2", "WBGene00013748" ] }, "reaction_10511995": { "compartment": "compartment_70101", "id": "reaction_10511995", "reactome": "R-CEL-176606", "name": "Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_158466" ], "products": [ "species_29372", "species_76577" ], "modifiers": [ [ "species_10511992", "catalyst" ] ], "additional_components": [ "WBGene00044063" ] }, "reaction_10509949": { "compartment": "compartment_70101", "id": "reaction_10509949", "reactome": "R-CEL-158849", "name": "Phenol can form a sulfate conjugate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158858", "species_158471" ], "products": [ "species_158466", "species_158850" ], "modifiers": [ [ "species_10509940", "catalyst" ] ], "additional_components": [ "Q9U2Z2", "WBGene00013748" ] }, "reaction_10511997": { "compartment": "compartment_70101", "id": "reaction_10511997", "reactome": "R-CEL-176609", "name": "cholesterol + PAPS => cholesterol sulfate + PAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_176478", "species_158471" ], "products": [ "species_176618", "species_158466" ], "modifiers": [ [ "species_10511962", "catalyst" ] ], "additional_components": [ "Q9U2Z2", "WBGene00013748" ] }, "reaction_10511965": { "compartment": "compartment_70101", "id": "reaction_10511965", "reactome": "R-CEL-176494", "name": "SULTs transfer (SO4)2- group to 27HCHOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_176617", "species_158471" ], "products": [ "species_176502", "species_158466" ], "modifiers": [ [ "species_10511962", "catalyst" ] ], "additional_components": [ "Q9U2Z2", "WBGene00013748" ] }, "reaction_10509951": { "compartment": "compartment_70101", "id": "reaction_10509951", "reactome": "R-CEL-158860", "name": "SULT1A1 dimer sulfonates NHABP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158847", "species_158471" ], "products": [ "species_158859", "species_158466" ], "modifiers": [ [ "species_10509940", "catalyst" ] ], "additional_components": [ "Q9U2Z2", "WBGene00013748" ] }, "reaction_10510057": { "compartment": "compartment_5460", "id": "reaction_10510057", "reactome": "R-CEL-159566", "name": "benzoyl-CoA + glycine => benzoyl glycine (hippuric acid) + Coenzyme A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_159549", "species_159447" ], "products": [ "species_29374", "species_159564" ], "modifiers": [ [ "species_10510054", "catalyst" ] ], "additional_components": [ "Q95ZT6", "WBGene00018400", "Q22371", "WBGene00018400" ] }, "reaction_10510059": { "compartment": "compartment_5460", "id": "reaction_10510059", "reactome": "R-CEL-159574", "name": "salicylate-CoA + glycine => salicyluric acid + Coenzyme A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_159549", "species_159557" ], "products": [ "species_29374", "species_159572" ], "modifiers": [ [ "species_10510054", "catalyst" ] ], "additional_components": [ "Q95ZT6", "WBGene00018400", "Q22371", "WBGene00018400" ] }, "reaction_10511744": { "compartment": "compartment_12045", "id": "reaction_10511744", "reactome": "R-CEL-174368", "name": "SLC35D1 hexamer transports UDP-GlcA, UDP-GlcNAc from cytosol to endoplasmic reticulum lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158601", "species_162756" ], "products": [ "species_3499326", "species_174384" ], "modifiers": [ [ "species_10511741", "catalyst" ] ], "additional_components": [ "Q18779", "WBGene00005025" ] }, "reaction_10502868": { "compartment": "compartment_70101", "id": "reaction_10502868", "reactome": "R-CEL-70286", "name": "UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29548", "species_29494" ], "products": [ "species_111294", "species_29410" ], "modifiers": [ [ "species_10502865", "catalyst" ] ], "additional_components": [ "Q9XUS5", "WBGene00010665" ] }, "reaction_10511557": { "compartment": "compartment_70101", "id": "reaction_10511557", "reactome": "R-CEL-173597", "name": "UDP-glucose is oxidised to UDP-glucuronate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_29410", "species_29360" ], "products": [ "species_70106", "species_158601", "species_73473" ], "modifiers": [ [ "species_10511554", "catalyst" ] ], "additional_components": [ "Q19905", "WBGene00005022" ] }, "reaction_10557073": { "compartment": "compartment_17957", "id": "reaction_10557073", "reactome": "R-CEL-5693724", "name": "ESD dimer hydrolyses S-FGSH to GSH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113519", "species_5693723" ], "products": [ "species_158543", "species_194712" ], "modifiers": [ [ "species_10557070", "catalyst" ] ], "additional_components": [ "G5EF86", "WBGene00013018" ] }, "reaction_10547222": { "compartment": "compartment_5460", "id": "reaction_10547222", "reactome": "R-CEL-3301943", "name": "GSTK1 dimer transfers GS from GSH to CDNB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1655887", "species_3301954" ], "products": [ "species_3301973", "species_3301969" ], "modifiers": [ [ "species_10547219", "catalyst" ] ], "additional_components": [ "Q18973", "WBGene00017054" ] }, "reaction_10532353": { "compartment": "compartment_70101", "id": "reaction_10532353", "reactome": "R-CEL-1247935", "name": "OPLAH hydrolyses OPRO to L-Glu", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_1247942" ], "products": [ "species_29372", "species_29404", "species_29370" ], "modifiers": [ [ "species_10532350", "catalyst" ] ], "additional_components": [ "A0A9S2", "WBGene00021430" ] }, "reaction_10511734": { "compartment": "compartment_70101", "id": "reaction_10511734", "reactome": "R-CEL-174367", "name": "GCL ligates L-Glu to L-Cys", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29404", "species_111707", "species_113592" ], "products": [ "species_29372", "species_174393", "species_29370" ], "modifiers": [ [ "species_10511731", "catalyst" ] ], "additional_components": [ "A9CZN9", "WBGene00017084", "Q20117", "WBGene00001527" ] }, "reaction_10532343": { "compartment": "compartment_70101", "id": "reaction_10532343", "reactome": "R-CEL-1247922", "name": "GGCT transforms gGluCys to OPRO", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_174393" ], "products": [ "species_111707", "species_1247942" ], "modifiers": [ [ "species_10532340", "catalyst" ] ], "additional_components": [ "Q18596", "WBGene00016629" ] }, "reaction_10568716": { "compartment": "compartment_876", "id": "reaction_10568716", "reactome": "R-CEL-8943279", "name": "GGT dimers hydrolyse GSH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_1247892" ], "products": [ "species_210382", "species_1247934" ], "modifiers": [ [ "species_10552351", "catalyst" ] ], "additional_components": [ "H2L0B7", "WBGene00020590", "O18256", "WBGene00020590", "Q9N5V4", "WBGene00020590", "A0A486WVP7", "WBGene00020590", "B5BM47", "WBGene00020590" ] }, "reaction_10532333": { "compartment": "compartment_70101", "id": "reaction_10532333", "reactome": "R-CEL-1247910", "name": "CNDP2:2Mn2+ dimer hydrolyses CysGly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1247904" ], "products": [ "species_111707", "species_29424" ], "modifiers": [ [ "species_10532330", "catalyst" ] ], "additional_components": [ "O18000", "WBGene00003982", "species_266099" ] }, "reaction_10511790": { "compartment": "compartment_70101", "id": "reaction_10511790", "reactome": "R-CEL-174394", "name": "GSS:Mg2+ dimer synthesizes GSH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_174393", "species_113592", "species_29424" ], "products": [ "species_29372", "species_29370", "species_29450" ], "modifiers": [ [ "species_10511787", "catalyst" ], [ "species_29450", "inhibitor" ] ], "additional_components": [ "species_114632", "Q21549", "WBGene00010941" ] }, "reaction_10511885": { "compartment": "compartment_70101", "id": "reaction_10511885", "reactome": "R-CEL-176054", "name": "GST dimers conjugate GSH with cytosolic substrates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29450", "species_176070" ], "products": [ "species_176049" ], "modifiers": [ [ "species_10511882", "catalyst" ] ], "additional_components": [ "CHEBI:29132", "species_3301954", "CHEBI:30614", "species_3301969", "CHEBI:32639", "CHEBI:34479", "Q18938", "WBGene00001790", "P34277", "WBGene00015337", "D7SFI3", "WBGene00043097", "P34345", "WBGene00016204", "O17234", "WBGene00019636", "O45352", "WBGene00001792", "Q09607", "WBGene00001784", "P10299", "WBGene00001749" ] }, "reaction_10556844": { "compartment": "compartment_70101", "id": "reaction_10556844", "reactome": "R-CEL-5692232", "name": "AKR1A1 oxidises BaPtDHD to BaP-7,8-dione", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29366", "species_5692212" ], "products": [ "species_5692216", "species_29364" ], "modifiers": [ [ "species_10554514", "catalyst" ] ], "additional_components": [ "WBGene00012722" ] }, "reaction_10510318": { "compartment": "compartment_20699", "id": "reaction_10510318", "reactome": "R-CEL-163843", "name": "Furin cleaves pro-GAS6 to GAS6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10510296" ], "products": [ "species_10510310", "species_10510304" ], "modifiers": [ [ "species_10510315", "catalyst" ] ], "additional_components": [ "G5EFX3", "WBGene00013416", "Q9XWD6", "WBGene00000415", "G5EFX3", "WBGene00013416", "Q9XWD6", "WBGene00000415", "G5EFX3", "WBGene00013416", "Q9XWD6", "WBGene00000415", "WBGene00002232" ] }, "reaction_10510298": { "compartment": "compartment_13959", "id": "reaction_10510298", "reactome": "R-CEL-163809", "name": "Gamma-carboxy pro-GAS6 transport from the endoplasmic reticulum to the Golgi apparatus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10510290" ], "products": [ "species_10510296" ], "modifiers": [], "additional_components": [ "G5EFX3", "WBGene00013416", "Q9XWD6", "WBGene00000415", "G5EFX3", "WBGene00013416", "Q9XWD6", "WBGene00000415" ] }, "reaction_10558353": { "compartment": "compartment_70101", "id": "reaction_10558353", "reactome": "R-CEL-6788867", "name": "FN3K phosphorylates ketosamines", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_6788868" ], "products": [ "species_29370", "species_6788848" ], "modifiers": [ [ "species_10558348", "catalyst" ] ], "additional_components": [ "CHEBI:87176", "CHEBI:24103", "CHEBI:87177", "CHEBI:87180", "CHEBI:87178", "CHEBI:87179", "WBGene00013802" ] }, "reaction_10516057": { "compartment": "compartment_70101", "id": "reaction_10516057", "reactome": "R-CEL-204662", "name": "DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29368", "species_10516005", "species_73473" ], "products": [ "species_10516047", "species_29356", "species_29360" ], "modifiers": [ [ "species_10516054", "catalyst" ] ], "additional_components": [ "Q20751", "WBGene00002065", "P34563", "WBGene00002064", "P34563", "WBGene00002064", "Q20751", "WBGene00002065", "Q17949", "WBGene00007555", "species_113531" ] }, "reaction_10516029": { "compartment": "compartment_70101", "id": "reaction_10516029", "reactome": "R-CEL-204617", "name": "DHPS tetramer synthesizes EIF5A and spermidine from Dhp-K50-EIF5A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_204628", "species_10516005", "species_73473" ], "products": [ "species_204635", "species_10516019", "species_29360" ], "modifiers": [ [ "species_10516026", "catalyst" ] ], "additional_components": [ "Q20751", "WBGene00002065", "P34563", "WBGene00002064", "P34563", "WBGene00002064", "Q20751", "WBGene00002065", "Q9XXJ0", "WBGene00012460" ] }, "reaction_10551593": { "compartment": "compartment_70101", "id": "reaction_10551593", "reactome": "R-CEL-5358484", "name": "DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10551582", "species_71284" ], "products": [ "species_71285", "species_10551585" ], "modifiers": [ [ "species_10551590", "catalyst" ] ], "additional_components": [ "WBGene00001167", "WBGene00001167", "WBGene00007194" ] }, "reaction_10551579": { "compartment": "compartment_70101", "id": "reaction_10551579", "reactome": "R-CEL-5358475", "name": "DPH6 ligates ammonium to diphthine-EEF2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10551571", "species_31633" ], "products": [ "species_111294", "species_10509919", "species_76577" ], "modifiers": [ [ "species_10551576", "catalyst" ] ], "additional_components": [ "WBGene00001167", "WBGene00001167", "WBGene00017087" ] }, "reaction_10551615": { "compartment": "compartment_70101", "id": "reaction_10551615", "reactome": "R-CEL-5358494", "name": "DPH2 transfers a 3-amino-3-carboxypropyl group from AdoMet to residue 715 of nascent EEF2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10551595", "species_71284" ], "products": [ "species_10551582", "species_353106" ], "modifiers": [ [ "species_10551612", "catalyst" ] ], "additional_components": [ "WBGene00001167", "WBGene00001167", "P49958", "WBGene00007576", "Q09454", "WBGene00007488", "Q21102", "WBGene00010484" ] }, "reaction_10558335": { "compartment": "compartment_12045", "id": "reaction_10558335", "reactome": "R-CEL-6788650", "name": "ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6788753", "species_71284" ], "products": [ "species_71285", "species_6788758" ], "modifiers": [ [ "species_10558332", "catalyst" ] ], "additional_components": [ "species_216785", "P91402", "WBGene00019710" ] }, "reaction_10558351": { "compartment": "compartment_70101", "id": "reaction_10558351", "reactome": "R-CEL-6788855", "name": "FN3KRP phosphorylates PsiAm, RibAm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_6788865" ], "products": [ "species_6788858", "species_29370" ], "modifiers": [ [ "species_10558348", "catalyst" ] ], "additional_components": [ "CHEBI:87176", "CHEBI:87177", "CHEBI:87180", "CHEBI:87179", "WBGene00013802" ] }, "reaction_10570837": { "compartment": "compartment_876", "id": "reaction_10570837", "reactome": "R-CEL-9010872", "name": "SLIT2 binds Dystroglycan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10519315", "species_10570833" ], "products": [ "species_10570835" ], "modifiers": [], "additional_components": [ "WBGene00004854", "O61756", "WBGene00018943", "Q22629", "WBGene00000961", "O61756", "WBGene00018943", "Q22629", "WBGene00000961", "G5EFX6", "WBGene00004854" ] }, "reaction_10564693": { "compartment": "compartment_20699", "id": "reaction_10564693", "reactome": "R-CEL-8848484", "name": "PLA2s hydrolyze phospholipids at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_429785", "species_29356" ], "products": [ "species_6814303", "species_8848483" ], "modifiers": [ [ "species_10534904", "catalyst" ] ], "additional_components": [ "WBGene00016661" ] }, "reaction_10564918": { "compartment": "compartment_12045", "id": "reaction_10564918", "reactome": "R-CEL-8849353", "name": "Dynein drives COPI-independent retrograde traffic from the Golgi to the ER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10564872" ], "products": [ "species_29370", "species_10564859", "species_10553033", "species_10564898" ], "modifiers": [ [ "species_8848483", "catalyst" ], [ "species_10564916", "catalyst" ] ], "additional_components": [ "Q19020", "WBGene00000962", "O45087", "WBGene00015927", "Q65XS9", "WBGene00043067", "A0AAC1", "WBGene00012424", "Q7YTJ8", "WBGene00012425", "Q21557", "WBGene00010888", "Q22799", "WBGene00001005", "G5ED34", "WBGene00001007", "species_29420", "species_29438", "Q9NA98", "WBGene00013168", "P34685", "WBGene00000292", "P34686", "WBGene00000293", "Q18194", "WBGene00016124", "Q9N4I1", "WBGene00022118", "Q9N3F1", "WBGene00021827", "Q9GYR2", "WBGene00016793", "Q09248", "WBGene00001018", "E2JKZ0", "WBGene00001017", "V6CJ04", "WBGene00016611", "Q22782", "WBGene00004270", "P34213", "WBGene00004269", "Q8I136", "WBGene00001629", "O61394", "WBGene00001631", "V6CJ04", "WBGene00016611", "Q19020", "WBGene00000962", "O45087", "WBGene00015927", "Q65XS9", "WBGene00043067", "A0AAC1", "WBGene00012424", "Q7YTJ8", "WBGene00012425", "Q21557", "WBGene00010888", "Q22799", "WBGene00001005", "G5ED34", "WBGene00001007", "species_29420", "species_29438", "Q9NA98", "WBGene00013168", "P34685", "WBGene00000292", "P34686", "WBGene00000293", "Q18194", "WBGene00016124", "Q9N4I1", "WBGene00022118", "Q9N3F1", "WBGene00021827", "Q9GYR2", "WBGene00016793", "Q09248", "WBGene00001018", "E2JKZ0", "WBGene00001017", "O61394", "WBGene00001631", "Q8I136", "WBGene00001629", "P34213", "WBGene00004269", "Q22782", "WBGene00004270", "species_29438", "Q8MXS1", "WBGene00004277", "species_29438", "Q93538", "WBGene00004317", "Q22670", "WBGene00004318" ] }, "reaction_10564982": { "compartment": "compartment_12045", "id": "reaction_10564982", "reactome": "R-CEL-8850040", "name": "RAB3GAP1:RAB3GAP2 recruits RAB18:GCDP to ER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10564910", "species_10564978" ], "products": [ "species_10564980" ], "modifiers": [], "additional_components": [ "Q93538", "WBGene00004317", "Q22670", "WBGene00004318", "Q8MXS1", "WBGene00004277", "species_29420", "Q8MXS1", "WBGene00004277", "species_29420", "Q93538", "WBGene00004317", "Q22670", "WBGene00004318" ] }, "reaction_10564985": { "compartment": "compartment_12045", "id": "reaction_10564985", "reactome": "R-CEL-8850041", "name": "RAB3GAP1:RAB3GAP2 promotes nucleotide exchange on RAB18", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10564980" ], "products": [ "species_29420", "species_10564916" ], "modifiers": [ [ "species_10564980", "catalyst" ] ], "additional_components": [ "Q8MXS1", "WBGene00004277", "species_29420", "Q93538", "WBGene00004317", "Q22670", "WBGene00004318", "Q8MXS1", "WBGene00004277", "species_29438", "Q93538", "WBGene00004317", "Q22670", "WBGene00004318", "Q8MXS1", "WBGene00004277", "species_29420", "Q93538", "WBGene00004317", "Q22670", "WBGene00004318" ] }, "reaction_10564874": { "compartment": "compartment_20699", "id": "reaction_10564874", "reactome": "R-CEL-8849350", "name": "RAB6:GTP displaces PAFAH1B1 from dynein:dynactin complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10564861", "species_10564870" ], "products": [ "species_10564872", "species_10564868" ], "modifiers": [], "additional_components": [ "V6CJ04", "WBGene00016611", "Q22782", "WBGene00004270", "P34213", "WBGene00004269", "species_29438", "Q8I136", "WBGene00001629", "O61394", "WBGene00001631", "Q9NDC9", "WBGene00003047", "Q19020", "WBGene00000962", "O45087", "WBGene00015927", "Q65XS9", "WBGene00043067", "A0AAC1", "WBGene00012424", "Q7YTJ8", "WBGene00012425", "Q21557", "WBGene00010888", "Q22799", "WBGene00001005", "G5ED34", "WBGene00001007", "species_29420", "species_29438", "Q9NA98", "WBGene00013168", "P34685", "WBGene00000292", "P34686", "WBGene00000293", "Q18194", "WBGene00016124", "Q9N4I1", "WBGene00022118", "Q9N3F1", "WBGene00021827", "Q9GYR2", "WBGene00016793", "Q09248", "WBGene00001018", "E2JKZ0", "WBGene00001017", "Q19020", "WBGene00000962", "O45087", "WBGene00015927", "Q65XS9", "WBGene00043067", "A0AAC1", "WBGene00012424", "Q7YTJ8", "WBGene00012425", "Q21557", "WBGene00010888", "Q22799", "WBGene00001005", "G5ED34", "WBGene00001007", "species_29420", "species_29438", "Q9NA98", "WBGene00013168", "P34685", "WBGene00000292", "P34686", "WBGene00000293", "Q18194", "WBGene00016124", "Q9N4I1", "WBGene00022118", "Q9N3F1", "WBGene00021827", "Q9GYR2", "WBGene00016793", "Q09248", "WBGene00001018", "E2JKZ0", "WBGene00001017", "V6CJ04", "WBGene00016611", "Q22782", "WBGene00004270", "P34213", "WBGene00004269", "Q8I136", "WBGene00001629", "O61394", "WBGene00001631", "WBGene00003047" ] }, "reaction_10564863": { "compartment": "compartment_20699", "id": "reaction_10564863", "reactome": "R-CEL-8849348", "name": "RAB6:GTP and BICD homodimers bind COPI-independent Golgi-to-ER retrograde cargo", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10564846", "species_10564844", "species_10564859" ], "products": [ "species_10564861" ], "modifiers": [], "additional_components": [ "Q8I136", "WBGene00001629", "O61394", "WBGene00001631", "Q22782", "WBGene00004270", "P34213", "WBGene00004269", "species_29438", "V6CJ04", "WBGene00016611", "V6CJ04", "WBGene00016611", "Q22782", "WBGene00004270", "P34213", "WBGene00004269", "species_29438", "Q8I136", "WBGene00001629", "O61394", "WBGene00001631" ] }, "reaction_10563841": { "compartment": "compartment_20699", "id": "reaction_10563841", "reactome": "R-CEL-6811414", "name": "GBF1 stimulates nucleotide exchange on ARF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10563830" ], "products": [ "species_29420", "species_10563834" ], "modifiers": [ [ "species_10563830", "catalyst" ] ], "additional_components": [ "G5EGS5", "WBGene00007703", "Q9UAQ6", "WBGene00004266", "species_29438", "Q94231", "WBGene00000190", "species_29420", "G5EGS5", "WBGene00007703", "Q9UAQ6", "WBGene00004266", "species_29438", "Q94231", "WBGene00000190", "G5EGS5", "WBGene00007703", "Q9UAQ6", "WBGene00004266", "species_29438", "Q94231", "WBGene00000190", "species_29420" ] }, "reaction_10563843": { "compartment": "compartment_20699", "id": "reaction_10563843", "reactome": "R-CEL-6811415", "name": "RAB:GTP recruits GBF1 to the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10563535", "species_10563179" ], "products": [ "species_10563828" ], "modifiers": [], "additional_components": [ "Q9UAQ6", "WBGene00004266", "species_29438", "WBGene00007703", "G5EGS5", "WBGene00007703", "Q9UAQ6", "WBGene00004266", "species_29438" ] }, "reaction_10563890": { "compartment": "compartment_12045", "id": "reaction_10563890", "reactome": "R-CEL-6811422", "name": "NSF ATPase activity dissociates cis-SNARE at the ER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10563887", "species_113592" ], "products": [ "species_29372", "species_10563883", "species_10515624", "species_10563878", "species_10557345", "species_10557329", "species_10563873" ], "modifiers": [ [ "species_10563887", "catalyst" ] ], "additional_components": [ "Q18921", "WBGene00017016", "Q94392", "WBGene00003818", "Q94241", "WBGene00018853", "C0Z1Y7", "WBGene00018239", "O76413", "WBGene00020425", "Q9N598", "WBGene00022460", "WBGene00022460", "WBGene00018853", "WBGene00020425", "Q18921", "WBGene00017016", "Q94392", "WBGene00003818", "WBGene00018239", "Q18921", "WBGene00017016", "Q94392", "WBGene00003818", "Q94241", "WBGene00018853", "C0Z1Y7", "WBGene00018239", "O76413", "WBGene00020425", "Q9N598", "WBGene00022460" ] }, "reaction_10563832": { "compartment": "compartment_20699", "id": "reaction_10563832", "reactome": "R-CEL-6811411", "name": "GBF1 recruits ARF:GDP to the Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10563191", "species_10563828" ], "products": [ "species_10563830" ], "modifiers": [], "additional_components": [ "Q94231", "WBGene00000190", "species_29420", "G5EGS5", "WBGene00007703", "Q9UAQ6", "WBGene00004266", "species_29438", "G5EGS5", "WBGene00007703", "Q9UAQ6", "WBGene00004266", "species_29438", "Q94231", "WBGene00000190", "species_29420" ] }, "reaction_10563898": { "compartment": "compartment_12045", "id": "reaction_10563898", "reactome": "R-CEL-6811425", "name": "NSF and SNAPs bind cis-SNARE at the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10563896", "species_10557329", "species_10557345" ], "products": [ "species_10563887" ], "modifiers": [], "additional_components": [ "Q94241", "WBGene00018853", "C0Z1Y7", "WBGene00018239", "O76413", "WBGene00020425", "Q9N598", "WBGene00022460", "Q94392", "WBGene00003818", "Q18921", "WBGene00017016", "Q18921", "WBGene00017016", "Q94392", "WBGene00003818", "Q94241", "WBGene00018853", "C0Z1Y7", "WBGene00018239", "O76413", "WBGene00020425", "Q9N598", "WBGene00022460" ] }, "reaction_10563868": { "compartment": "compartment_20699", "id": "reaction_10563868", "reactome": "R-CEL-6811418", "name": "ARFGAPs stimulate ARF GTPase activity at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10563853" ], "products": [ "species_10563262", "species_10563179", "species_10563865", "species_10563191" ], "modifiers": [ [ "species_10563853", "catalyst" ] ], "additional_components": [ "Q94241", "WBGene00018853", "Q09473", "WBGene00016195", "P48583", "WBGene00001331", "Q18864", "WBGene00004788", "Q20546", "WBGene00009829", "A4F319", "WBGene00011606", "Q9U1Z4", "WBGene00013360", "O17528", "WBGene00004766", "O44738", "WBGene00019003", "G5EGS5", "WBGene00007703", "Q9UAQ6", "WBGene00004266", "species_29438", "Q94231", "WBGene00000190", "Q09236", "WBGene00015734", "Q22498", "WBGene00011775", "Q9TYL9", "WBGene00021292", "O17901", "WBGene00010333", "Q20168", "WBGene00009542", "O62246", "WBGene00009732", "Q9N4H7", "WBGene00022119", "Q09531", "WBGene00017217", "P90904", "WBGene00010500", "Q09531", "WBGene00017217", "P90904", "WBGene00010500", "WBGene00007703", "Q94241", "WBGene00018853", "Q9UAQ6", "WBGene00004266", "species_29438", "P48583", "WBGene00001331", "Q09473", "WBGene00016195", "Q18864", "WBGene00004788", "Q20546", "WBGene00009829", "Q9U1Z4", "WBGene00013360", "A4F319", "WBGene00011606", "O17528", "WBGene00004766", "O44738", "WBGene00019003", "Q09236", "WBGene00015734", "Q9TYL9", "WBGene00021292", "Q22498", "WBGene00011775", "O17901", "WBGene00010333", "Q9N4H7", "WBGene00022119", "Q20168", "WBGene00009542", "O62246", "WBGene00009732", "Q94231", "WBGene00000190", "species_29420", "Q94241", "WBGene00018853", "Q09473", "WBGene00016195", "P48583", "WBGene00001331", "Q18864", "WBGene00004788", "Q20546", "WBGene00009829", "A4F319", "WBGene00011606", "Q9U1Z4", "WBGene00013360", "O17528", "WBGene00004766", "O44738", "WBGene00019003", "G5EGS5", "WBGene00007703", "Q9UAQ6", "WBGene00004266", "species_29438", "Q94231", "WBGene00000190", "Q09236", "WBGene00015734", "Q22498", "WBGene00011775", "Q9TYL9", "WBGene00021292", "O17901", "WBGene00010333", "Q20168", "WBGene00009542", "O62246", "WBGene00009732", "Q9N4H7", "WBGene00022119", "Q09531", "WBGene00017217", "P90904", "WBGene00010500" ] }, "reaction_10563855": { "compartment": "compartment_20699", "id": "reaction_10563855", "reactome": "R-CEL-6811417", "name": "ARFGAP, cargo, vSNARES and p24 proteins bind COPI vesicles at Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10563262", "species_10563836", "species_10563565", "species_10563851", "species_10563845" ], "products": [ "species_10563853" ], "modifiers": [], "additional_components": [ "Q09531", "WBGene00017217", "P90904", "WBGene00010500", "G5EGS5", "WBGene00007703", "Q9UAQ6", "WBGene00004266", "species_29438", "Q94231", "WBGene00000190", "Q09236", "WBGene00015734", "Q22498", "WBGene00011775", "Q9TYL9", "WBGene00021292", "O17901", "WBGene00010333", "Q20168", "WBGene00009542", "O62246", "WBGene00009732", "Q9N4H7", "WBGene00022119", "O44738", "WBGene00019003", "Q20546", "WBGene00009829", "A4F319", "WBGene00011606", "Q9U1Z4", "WBGene00013360", "O17528", "WBGene00004766", "Q09473", "WBGene00016195", "P48583", "WBGene00001331", "Q18864", "WBGene00004788", "Q20546", "WBGene00009829", "A4F319", "WBGene00011606", "Q9U1Z4", "WBGene00013360", "O17528", "WBGene00004766", "WBGene00018853", "Q94241", "WBGene00018853", "Q09473", "WBGene00016195", "P48583", "WBGene00001331", "Q18864", "WBGene00004788", "Q20546", "WBGene00009829", "A4F319", "WBGene00011606", "Q9U1Z4", "WBGene00013360", "O17528", "WBGene00004766", "O44738", "WBGene00019003", "G5EGS5", "WBGene00007703", "Q9UAQ6", "WBGene00004266", "species_29438", "Q94231", "WBGene00000190", "Q09236", "WBGene00015734", "Q22498", "WBGene00011775", "Q9TYL9", "WBGene00021292", "O17901", "WBGene00010333", "Q20168", "WBGene00009542", "O62246", "WBGene00009732", "Q9N4H7", "WBGene00022119", "Q09531", "WBGene00017217", "P90904", "WBGene00010500" ] }, "reaction_10563838": { "compartment": "compartment_20699", "id": "reaction_10563838", "reactome": "R-CEL-6811412", "name": "Active ARF recruits coatomer to the Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10563244", "species_10563834" ], "products": [ "species_10563836" ], "modifiers": [], "additional_components": [ "Q09236", "WBGene00015734", "Q22498", "WBGene00011775", "Q9TYL9", "WBGene00021292", "O17901", "WBGene00010333", "Q20168", "WBGene00009542", "O62246", "WBGene00009732", "Q9N4H7", "WBGene00022119", "G5EGS5", "WBGene00007703", "Q9UAQ6", "WBGene00004266", "species_29438", "Q94231", "WBGene00000190", "G5EGS5", "WBGene00007703", "Q9UAQ6", "WBGene00004266", "species_29438", "Q94231", "WBGene00000190", "Q09236", "WBGene00015734", "Q22498", "WBGene00011775", "Q9TYL9", "WBGene00021292", "O17901", "WBGene00010333", "Q20168", "WBGene00009542", "O62246", "WBGene00009732", "Q9N4H7", "WBGene00022119" ] }, "reaction_10563982": { "compartment": "compartment_12045", "id": "reaction_10563982", "reactome": "R-CEL-6811427", "name": "COPI vesicle uncoating at the ER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10563980" ], "products": [ "species_10557214", "species_10563244", "species_10563978", "species_10563896", "species_10563936" ], "modifiers": [], "additional_components": [ "Q20546", "WBGene00009829", "O17528", "WBGene00004766", "O44738", "WBGene00019003", "A4F319", "WBGene00011606", "Q9U1Z4", "WBGene00013360", "Q94241", "WBGene00018853", "Q19642", "WBGene00017643", "P90841", "WBGene00008990", "Q9N4H7", "WBGene00022119", "Q20168", "WBGene00009542", "O62246", "WBGene00009732", "Q22498", "WBGene00011775", "O17901", "WBGene00010333", "Q09236", "WBGene00015734", "Q9TYL9", "WBGene00021292", "P48583", "WBGene00001331", "Q09473", "WBGene00016195", "Q18864", "WBGene00004788", "C0Z1Y7", "WBGene00018239", "O76413", "WBGene00020425", "Q9N598", "WBGene00022460", "Q9UAQ6", "WBGene00004266", "species_29438", "Q9UAQ6", "WBGene00004266", "species_29420", "Q09236", "WBGene00015734", "Q22498", "WBGene00011775", "Q9TYL9", "WBGene00021292", "O17901", "WBGene00010333", "Q20168", "WBGene00009542", "O62246", "WBGene00009732", "Q9N4H7", "WBGene00022119", "P48583", "WBGene00001331", "Q09473", "WBGene00016195", "Q20546", "WBGene00009829", "O17528", "WBGene00004766", "Q18864", "WBGene00004788", "A4F319", "WBGene00011606", "Q9U1Z4", "WBGene00013360", "Q94241", "WBGene00018853", "C0Z1Y7", "WBGene00018239", "O76413", "WBGene00020425", "Q9N598", "WBGene00022460", "Q20546", "WBGene00009829", "O17528", "WBGene00004766", "O44738", "WBGene00019003", "A4F319", "WBGene00011606", "Q9U1Z4", "WBGene00013360" ] }, "reaction_10555089": { "compartment": "compartment_876", "id": "reaction_10555089", "reactome": "R-CEL-5672980", "name": "Dissociation of RAS:RAF complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10555069" ], "products": [ "species_10555065", "species_10555030", "species_10508583", "species_10555044" ], "modifiers": [], "additional_components": [ "P39745", "WBGene00003401", "Q10664", "WBGene00003186", "Q07292", "WBGene00003030", "species_29438", "P22981", "WBGene00002335", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "Q10664", "WBGene00003186", "WBGene00003401", "Q07292", "WBGene00003030", "species_29438", "P22981", "WBGene00002335", "P41932", "WBGene00003920", "Q20655", "WBGene00001502" ] }, "reaction_10572917": { "compartment": "compartment_876", "id": "reaction_10572917", "reactome": "R-CEL-9657599", "name": "Dual mechanism MAP2K inhibitors bind MAP2Ks", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9657567", "species_10555042" ], "products": [ "species_10555074" ], "modifiers": [], "additional_components": [ "Q10664", "WBGene00003186", "Q07292", "WBGene00003030", "species_29438", "P22981", "WBGene00002335", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "P39745", "WBGene00003401", "Q10664", "WBGene00003186", "Q07292", "WBGene00003030", "species_29438", "P22981", "WBGene00002335", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "P39745", "WBGene00003401" ] }, "reaction_10555156": { "compartment": "compartment_20699", "id": "reaction_10555156", "reactome": "R-CEL-5674366", "name": "IL17RD binds p-2S MAP2Ks and MAPKs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508575", "species_10555065", "species_10555152" ], "products": [ "species_10555154" ], "modifiers": [], "additional_components": [ "WBGene00003401", "Q10664", "WBGene00003186", "Q10128", "WBGene00018960", "Q9NA64", "WBGene00013415", "Q10128", "WBGene00018960", "Q9NA64", "WBGene00013415", "Q10664", "WBGene00003186", "P39745", "WBGene00003401" ] }, "reaction_10572919": { "compartment": "compartment_876", "id": "reaction_10572919", "reactome": "R-CEL-9657603", "name": "Dual mechanism MAPK inhibitors bind MAPKs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10555067", "species_9657570" ], "products": [ "species_10555076" ], "modifiers": [], "additional_components": [ "Q10664", "WBGene00003186", "Q07292", "WBGene00003030", "species_29438", "P22981", "WBGene00002335", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "P39745", "WBGene00003401", "Q10664", "WBGene00003186", "Q07292", "WBGene00003030", "species_29438", "P22981", "WBGene00002335", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "P39745", "WBGene00003401" ] }, "reaction_10555078": { "compartment": "compartment_876", "id": "reaction_10555078", "reactome": "R-CEL-5672973", "name": "MAP2Ks phosphorylate MAPKs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10555067", "species_113592" ], "products": [ "species_10555069", "species_29370" ], "modifiers": [ [ "species_10555067", "catalyst" ], [ "species_10555074", "inhibitor" ], [ "species_10555076", "inhibitor" ], [ "species_10555072", "inhibitor" ] ], "additional_components": [ "Q10664", "WBGene00003186", "Q07292", "WBGene00003030", "species_29438", "P22981", "WBGene00002335", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "P39745", "WBGene00003401", "P39745", "WBGene00003401", "Q10664", "WBGene00003186", "Q07292", "WBGene00003030", "species_29438", "P22981", "WBGene00002335", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "Q10664", "WBGene00003186", "Q07292", "WBGene00003030", "species_29438", "P22981", "WBGene00002335", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "P39745", "WBGene00003401", "Q10664", "WBGene00003186", "Q07292", "WBGene00003030", "species_29438", "P22981", "WBGene00002335", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "P39745", "WBGene00003401", "Q10664", "WBGene00003186", "Q07292", "WBGene00003030", "species_29438", "P22981", "WBGene00002335", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "P39745", "WBGene00003401", "Q10664", "WBGene00003186", "Q07292", "WBGene00003030", "species_29438", "P22981", "WBGene00002335", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "P39745", "WBGene00003401" ] }, "reaction_10572921": { "compartment": "compartment_876", "id": "reaction_10572921", "reactome": "R-CEL-9657606", "name": "Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10555067", "species_9657574" ], "products": [ "species_10555072" ], "modifiers": [], "additional_components": [ "Q10664", "WBGene00003186", "Q07292", "WBGene00003030", "species_29438", "P22981", "WBGene00002335", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "P39745", "WBGene00003401", "Q10664", "WBGene00003186", "Q07292", "WBGene00003030", "species_29438", "P22981", "WBGene00002335", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "P39745", "WBGene00003401" ] }, "reaction_10555129": { "compartment": "compartment_74700", "id": "reaction_10555129", "reactome": "R-CEL-5674130", "name": "MAP2Ks and MAPKs are phosphorylated at the endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10555125" ], "products": [ "species_29370", "species_10555127" ], "modifiers": [], "additional_components": [ "Q19986", "WBGene00018014", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "Q10664", "WBGene00003186", "Q07292", "WBGene00003030", "P39745", "WBGene00003401", "Q19986", "WBGene00018014", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "Q07292", "WBGene00003030", "P39745", "WBGene00003401", "Q10664", "WBGene00003186" ] }, "reaction_10555161": { "compartment": "compartment_20699", "id": "reaction_10555161", "reactome": "R-CEL-5674373", "name": "MAP2Ks phosphorylate MAPK at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10555154" ], "products": [ "species_29370", "species_10555158" ], "modifiers": [ [ "species_10555154", "catalyst" ] ], "additional_components": [ "Q10128", "WBGene00018960", "Q9NA64", "WBGene00013415", "Q10664", "WBGene00003186", "P39745", "WBGene00003401", "Q10128", "WBGene00018960", "Q9NA64", "WBGene00013415", "P39745", "WBGene00003401", "Q10664", "WBGene00003186", "Q10128", "WBGene00018960", "Q9NA64", "WBGene00013415", "Q10664", "WBGene00003186", "P39745", "WBGene00003401" ] }, "reaction_10555131": { "compartment": "compartment_74700", "id": "reaction_10555131", "reactome": "R-CEL-5674132", "name": "WDR83:LAMTOR2:LAMTOR3 binds MAPK components", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508575", "species_10555123", "species_10555040", "species_10555121" ], "products": [ "species_10555125" ], "modifiers": [], "additional_components": [ "WBGene00003401", "Q07292", "WBGene00003030", "Q10664", "WBGene00003186", "Q19986", "WBGene00018014", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "Q19986", "WBGene00018014", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "Q10664", "WBGene00003186", "Q07292", "WBGene00003030", "P39745", "WBGene00003401" ] }, "reaction_10555053": { "compartment": "compartment_876", "id": "reaction_10555053", "reactome": "R-CEL-5672972", "name": "MAP2Ks and MAPKs bind to the activated RAF complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508575", "species_10555006", "species_10555030", "species_10555040" ], "products": [ "species_10555042" ], "modifiers": [ [ "species_10555051", "inhibitor" ] ], "additional_components": [ "WBGene00003401", "Q07292", "WBGene00003030", "species_29438", "P22981", "WBGene00002335", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "Q10664", "WBGene00003186", "Q10664", "WBGene00003186", "Q07292", "WBGene00003030", "species_29438", "P22981", "WBGene00002335", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "P39745", "WBGene00003401", "Q07292", "WBGene00003030", "species_29438", "P22981", "WBGene00002335", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "O16264", "WBGene00018218" ] }, "reaction_10572925": { "compartment": "compartment_876", "id": "reaction_10572925", "reactome": "R-CEL-9657608", "name": "Single mechanism MAPK inhibitors bind phosphorylated MAPK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10555069", "species_9657577" ], "products": [ "species_10572923" ], "modifiers": [], "additional_components": [ "P39745", "WBGene00003401", "Q10664", "WBGene00003186", "Q07292", "WBGene00003030", "species_29438", "P22981", "WBGene00002335", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "P39745", "WBGene00003401", "Q10664", "WBGene00003186", "Q07292", "WBGene00003030", "species_29438", "P22981", "WBGene00002335", "P41932", "WBGene00003920", "Q20655", "WBGene00001502" ] }, "reaction_10555086": { "compartment": "compartment_876", "id": "reaction_10555086", "reactome": "R-CEL-5672978", "name": "RAF phosphorylates MAP2K dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10555042" ], "products": [ "species_10555067", "species_29370" ], "modifiers": [ [ "species_10555042", "catalyst" ], [ "species_10555084", "inhibitor" ], [ "species_10555074", "inhibitor" ] ], "additional_components": [ "Q10664", "WBGene00003186", "Q07292", "WBGene00003030", "species_29438", "P22981", "WBGene00002335", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "P39745", "WBGene00003401", "Q10664", "WBGene00003186", "Q07292", "WBGene00003030", "species_29438", "P22981", "WBGene00002335", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "P39745", "WBGene00003401", "Q10664", "WBGene00003186", "Q07292", "WBGene00003030", "species_29438", "P22981", "WBGene00002335", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "P39745", "WBGene00003401", "Q07292", "WBGene00003030", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "species_29438", "P22981", "WBGene00002335", "Q10664", "WBGene00003186", "Q07292", "WBGene00003030", "species_29438", "P22981", "WBGene00002335", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "P39745", "WBGene00003401" ] }, "reaction_10534928": { "compartment": "compartment_12045", "id": "reaction_10534928", "reactome": "R-CEL-1482900", "name": "PG is hydrolyzed to 1-acyl LPG by PLA2[1]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1483256", "species_29356" ], "products": [ "species_1524021", "species_1498740" ], "modifiers": [ [ "species_10534783", "catalyst" ] ], "additional_components": [ "O16654", "WBGene00044468", "Q17790", "WBGene00044468", "Q3V5J7", "WBGene00044468" ] }, "reaction_10535857": { "compartment": "compartment_984", "id": "reaction_10535857", "reactome": "R-CEL-1602368", "name": "PG is hydrolyzed to 1-acyl LPG by PLA2[16]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_1602402" ], "products": [ "species_1602415", "species_1602366" ], "modifiers": [ [ "species_10535837", "catalyst" ], [ "species_10535855", "inhibitor" ] ], "additional_components": [ "species_74016", "Q17790", "WBGene00044468", "O16654", "WBGene00044468", "Q3V5J7", "WBGene00044468", "Q18339", "WBGene00016288", "G4RY15", "WBGene00015631", "P34472", "WBGene00010228", "Q22591", "WBGene00020585" ] }, "reaction_10534930": { "compartment": "compartment_12045", "id": "reaction_10534930", "reactome": "R-CEL-1482907", "name": "PG is hydrolyzed to 1-acyl LPG by PLA2G2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1483256", "species_29356" ], "products": [ "species_1524021", "species_1498740" ], "modifiers": [ [ "species_10534852", "catalyst" ] ], "additional_components": [ "Q3V5J7", "WBGene00044468", "O16654", "WBGene00044468", "Q17790", "WBGene00044468", "species_74016" ] }, "reaction_10534742": { "compartment": "compartment_12045", "id": "reaction_10534742", "reactome": "R-CEL-1482539", "name": "1-acyl LPG is acylated to PG by LPGAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500578", "species_1498740" ], "products": [ "species_1483256", "species_76194" ], "modifiers": [ [ "species_10534739", "catalyst" ] ], "additional_components": [ "WBGene00019465" ] }, "reaction_10534792": { "compartment": "compartment_12045", "id": "reaction_10534792", "reactome": "R-CEL-1482635", "name": "2-acyl LPG is acylated to PG by LPGAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1498730", "species_1500578" ], "products": [ "species_1483256", "species_76194" ], "modifiers": [ [ "species_10534739", "catalyst" ] ], "additional_components": [ "WBGene00019465" ] }, "reaction_10534858": { "compartment": "compartment_70616", "id": "reaction_10534858", "reactome": "R-CEL-1482689", "name": "1-acyl LPG is acylated to PG by CRLS1 (IM)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524027", "species_1524038" ], "products": [ "species_29374", "species_1524042" ], "modifiers": [ [ "species_10534747", "catalyst" ] ], "additional_components": [ "WBGene00017763" ] }, "reaction_10534750": { "compartment": "compartment_70616", "id": "reaction_10534750", "reactome": "R-CEL-1482546", "name": "2-acyl LPG is acylated to PG by CRLS1 (IM)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524047", "species_1524038" ], "products": [ "species_29374", "species_1524042" ], "modifiers": [ [ "species_10534747", "catalyst" ] ], "additional_components": [ "WBGene00017763" ] }, "reaction_10565132": { "compartment": "compartment_70101", "id": "reaction_10565132", "reactome": "R-CEL-8851827", "name": "RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10512175", "species_29438" ], "products": [ "species_29420", "species_10511481" ], "modifiers": [ [ "species_10554985", "catalyst" ] ], "additional_components": [ "species_29420", "P22981", "WBGene00002335", "species_29438", "P22981", "WBGene00002335", "Q9XVQ7", "WBGene00008711", "P29355", "WBGene00004774", "Q9N5D3", "WBGene00004947" ] }, "reaction_10565135": { "compartment": "compartment_70101", "id": "reaction_10565135", "reactome": "R-CEL-8851877", "name": "RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10512175", "species_29438" ], "products": [ "species_29420", "species_10511481" ], "modifiers": [ [ "species_10554983", "catalyst" ] ], "additional_components": [ "species_29420", "P22981", "WBGene00002335", "species_29438", "P22981", "WBGene00002335", "Q9XWK4", "WBGene00013202", "Q9XVQ7", "WBGene00008711", "Q9N5D3", "WBGene00004947" ] }, "reaction_10550976": { "compartment": "compartment_7660", "id": "reaction_10550976", "reactome": "R-CEL-5244669", "name": "CDK1 phosphorylates lamins and facilitates depolymerization of lamin filaments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10550899" ], "products": [ "species_113582", "species_10550974" ], "modifiers": [ [ "species_10511241", "catalyst" ] ], "additional_components": [ "Q19782", "WBGene00002058", "P90900", "WBGene00002052", "Q21065", "WBGene00002051", "P90901", "WBGene00002050", "Q21067", "WBGene00002056", "Q09501", "WBGene00002067", "Q21443", "WBGene00003052", "Q19286", "WBGene00002054", "O02365", "WBGene00003485", "Q86DC6", "WBGene00002057", "Q19289", "WBGene00002053", "O45168", "WBGene00002055", "P90900", "WBGene00002052", "Q21443", "WBGene00003052", "P90901", "WBGene00002050", "Q86DC6", "WBGene00002057", "Q09501", "WBGene00002067", "Q19286", "WBGene00002054", "Q19289", "WBGene00002053", "Q19782", "WBGene00002058", "O02365", "WBGene00003485", "Q21065", "WBGene00002051", "O45168", "WBGene00002055", "Q21067", "WBGene00002056", "O45926", "WBGene00000866", "Q10653", "WBGene00000865", "Q9BLB5", "WBGene00000867", "P34556", "WBGene00000405" ] }, "reaction_10550709": { "compartment": "compartment_13231", "id": "reaction_10550709", "reactome": "R-CEL-5221130", "name": "LPIN catalyzes conversion of phosphatidic acid to diacylglycerol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_5221122" ], "products": [ "species_113550", "species_5221124" ], "modifiers": [ [ "species_10549162", "catalyst" ] ], "additional_components": [ "WBGene00010425" ] }, "reaction_10550349": { "compartment": "compartment_7660", "id": "reaction_10550349", "reactome": "R-CEL-5195402", "name": "CDK1 phosphorylates LPIN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10549162" ], "products": [ "species_113582", "species_10549156" ], "modifiers": [ [ "species_10511241", "catalyst" ] ], "additional_components": [ "WBGene00010425", "WBGene00010425", "O45926", "WBGene00000866", "Q10653", "WBGene00000865", "Q9BLB5", "WBGene00000867", "P34556", "WBGene00000405" ] }, "reaction_10549181": { "compartment": "compartment_13231", "id": "reaction_10549181", "reactome": "R-CEL-4419948", "name": "CTDNEP1:CNEP1R1 dephosphorylates LPIN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10549156" ], "products": [ "species_113550", "species_10549162" ], "modifiers": [ [ "species_10549178", "catalyst" ] ], "additional_components": [ "WBGene00010425", "WBGene00010425", "Q20432", "WBGene00018474", "Q9XXN3", "WBGene00011828" ] }, "reaction_10550717": { "compartment": "compartment_13231", "id": "reaction_10550717", "reactome": "R-CEL-5223304", "name": "DAG and Ca+2 bind to PKC and tether it to membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5221124", "species_29496", "species_10550711" ], "products": [ "species_10550715" ], "modifiers": [], "additional_components": [ "WBGene00004033", "P90980", "WBGene00004033", "species_74016", "species_114519" ] }, "reaction_10520494": { "compartment": "compartment_70101", "id": "reaction_10520494", "reactome": "R-CEL-388824", "name": "PTPRF, PTPRS, PTPRD bind Liprins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10520490", "species_10520454" ], "products": [ "species_10520492" ], "modifiers": [], "additional_components": [ "O01736", "WBGene00044348", "Q9BMN8", "WBGene00004215", "O17889", "WBGene00044348", "W6RR46", "WBGene00044348", "Q22852", "WBGene00044348", "Q95Y26", "WBGene00044348", "Q21049", "WBGene00006364", "Q94071", "WBGene00011904", "Q21049", "WBGene00006364", "Q94071", "WBGene00011904", "O01736", "WBGene00044348", "Q9BMN8", "WBGene00004215", "O17889", "WBGene00044348", "W6RR46", "WBGene00044348", "Q22852", "WBGene00044348", "Q95Y26", "WBGene00044348" ] }, "reaction_10559201": { "compartment": "compartment_876", "id": "reaction_10559201", "reactome": "R-CEL-6794346", "name": "NRXNs bind NLGNs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10559197", "species_10559159" ], "products": [ "species_10559199" ], "modifiers": [], "additional_components": [ "Q20826", "WBGene00018878", "Q9XTG1", "WBGene00006412", "I2HAJ6", "WBGene00007799", "O45000", "WBGene00002174", "I2HAJ6", "WBGene00007799", "O45000", "WBGene00002174", "Q20826", "WBGene00018878", "Q9XTG1", "WBGene00006412" ] }, "reaction_10559280": { "compartment": "compartment_876", "id": "reaction_10559280", "reactome": "R-CEL-6797554", "name": "ABP1 binds SHANK proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10515342", "species_10559276" ], "products": [ "species_10559278" ], "modifiers": [], "additional_components": [ "WBGene00010664", "G5ECY0", "WBGene00001006", "Q22638", "WBGene00011890", "I2HAJ6", "WBGene00007799", "O45000", "WBGene00002174", "Q20826", "WBGene00018878", "Q9XTG1", "WBGene00006412", "B7WN72", "WBGene00006444", "G5ECY0", "WBGene00001006", "Q22638", "WBGene00011890", "I2HAJ6", "WBGene00007799", "O45000", "WBGene00002174", "Q20826", "WBGene00018878", "Q9XTG1", "WBGene00006412", "B7WN72", "WBGene00006444", "Q9XUT0", "WBGene00010664" ] }, "reaction_10559284": { "compartment": "compartment_876", "id": "reaction_10559284", "reactome": "R-CEL-6797568", "name": "NRXNs bind CASK:Protein 4.1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10559199", "species_10559241" ], "products": [ "species_10559282" ], "modifiers": [], "additional_components": [ "I2HAJ6", "WBGene00007799", "O45000", "WBGene00002174", "Q20826", "WBGene00018878", "Q9XTG1", "WBGene00006412", "P54936", "WBGene00002991", "H2KZV9", "WBGene00001489", "G5EEG8", "WBGene00001488", "P54936", "WBGene00002991", "H2KZV9", "WBGene00001489", "G5EEG8", "WBGene00001488", "I2HAJ6", "WBGene00007799", "O45000", "WBGene00002174", "Q20826", "WBGene00018878", "Q9XTG1", "WBGene00006412" ] }, "reaction_10559243": { "compartment": "compartment_70101", "id": "reaction_10559243", "reactome": "R-CEL-6797553", "name": "Protein 4.1 binds CASK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10559239", "species_10519878" ], "products": [ "species_10559241" ], "modifiers": [], "additional_components": [ "H2KZV9", "WBGene00001489", "G5EEG8", "WBGene00001488", "WBGene00002991", "P54936", "WBGene00002991", "H2KZV9", "WBGene00001489", "G5EEG8", "WBGene00001488" ] }, "reaction_10564964": { "compartment": "compartment_876", "id": "reaction_10564964", "reactome": "R-CEL-8849878", "name": "PSD-95 binds NMDA receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10564960", "species_10523840" ], "products": [ "species_10564962" ], "modifiers": [], "additional_components": [ "G5EEH3", "WBGene00003775", "G5EGQ9", "WBGene00003774", "species_159549", "species_113552", "G5ECY0", "WBGene00001006", "Q22638", "WBGene00011890", "G5ECY0", "WBGene00001006", "Q22638", "WBGene00011890", "G5EEH3", "WBGene00003775", "G5EGQ9", "WBGene00003774", "species_159549", "species_113552" ] }, "reaction_10552287": { "compartment": "compartment_5460", "id": "reaction_10552287", "reactome": "R-CEL-5419261", "name": "55S ribosome with peptidyl-tRNA in A site binds GFM1:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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"WBGene00015133", "Q9TZ90", "WBGene00018793", "Q21083", "WBGene00010458", "O17005", "WBGene00020717", "Q7KPW7", "WBGene00017997", "Q4W5T0", "WBGene00044344", "Q22623", "WBGene00011883", "Q9NAG2", "WBGene00012992", "Q21939", "WBGene00011247", "O45110", "WBGene00018932", "O44159", "WBGene00016989", "Q95Y83", "WBGene00022470", "Q2L6V2", "WBGene00015092", "P34378", "WBGene00017044", "C0VXV6", "WBGene00021935", "Q9N3F3", "WBGene00021829", "Q95Y71", "WBGene00022493", "Q22140", "WBGene00011412", "P90915", "WBGene00010616", "P49404", "WBGene00016142", "Q95X39", "WBGene00015025", "O76606", "WBGene00020796", "Q9TYJ8", "WBGene00022045", "P91353", "WBGene00019076", "O17839", "WBGene00009128", "Q9GYS9", "WBGene00020348", "Q7YX52", "WBGene00008459", "Q9XX18", "WBGene00012645", "Q22438", "WBGene00011740", "Q6A575", "WBGene00023422", "Q7YWY8", "WBGene00010783", "O18199", "WBGene00013004", "species_29438", "Q95Y73", "WBGene00022491" ] }, "reaction_10552331": { "compartment": "compartment_5460", "id": "reaction_10552331", "reactome": "R-CEL-5419281", "name": "MRRF binds 55S ribosome:mRNA:tRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10552306", "species_10552320" ], "products": [ "species_10552329" ], "modifiers": [], "additional_components": [ "Q93425", "WBGene00008452", "Q9U3Q0", "WBGene00007564", "O61791", "WBGene00020037", "P34748", "WBGene00014224", "Q95Q11", "WBGene00013324", "Q688C0", "WBGene00023487", "P34388", "WBGene00017319", "Q9N361", "WBGene00021920", "Q95QS3", "WBGene00016412", "Q9XWV5", "WBGene00012556", "G5ECC9", "WBGene00010766", "Q22470", "WBGene00011759", "Q22483", "WBGene00020499", "Q9XWP0", "WBGene00012830", "G5EC67", "WBGene00013210", "Q23155", "WBGene00012244", "Q9XTY5", "WBGene00011391", "O61818", "WBGene00044321", "O44133", "WBGene00016057", "Q09261", "WBGene00007859", "G5EFC8", "WBGene00000933", "P49391", "WBGene00011334", "Q9NAP9", "WBGene00010624", "Q19685", "WBGene00009013", "Q9N584", "WBGene00002804", "Q21601", "WBGene00010905", "Q10129", "WBGene00018961", "O17004", "WBGene00020718", "Q11189", "WBGene00015487", "Q9NEI6", "WBGene00012697", "Q09523", "WBGene00008456", "Q9GYI2", "WBGene00017924", "Q21454", "WBGene00010812", "O02207", "WBGene00007215", "Q04907", "WBGene00016249", "Q95QC2", "WBGene00019838", "Q9UA63", "WBGene00021021", "P34384", "WBGene00008514", "Q9BPN6", "WBGene00022373", "O02220", "WBGene00007712", "Q95QL2", "WBGene00008769", "A0A1N7SYX2", "WBGene00003066", "O18180", "WBGene00012361", "P90993", "WBGene00015185", "P34264", "WBGene00015133", "Q9TZ90", "WBGene00018793", "Q21083", "WBGene00010458", "O17005", "WBGene00020717", "Q7KPW7", "WBGene00017997", "Q4W5T0", "WBGene00044344", "Q22623", "WBGene00011883", "Q9NAG2", "WBGene00012992", "Q21939", "WBGene00011247", "O45110", "WBGene00018932", "O44159", "WBGene00016989", "Q95Y83", "WBGene00022470", "Q2L6V2", "WBGene00015092", "P34378", "WBGene00017044", "C0VXV6", "WBGene00021935", "Q9N3F3", "WBGene00021829", "Q95Y71", "WBGene00022493", "Q22140", "WBGene00011412", "P90915", "WBGene00010616", "P49404", "WBGene00016142", "Q95X39", "WBGene00015025", "O76606", "WBGene00020796", "Q9TYJ8", "WBGene00022045", "P91353", "WBGene00019076", "O17839", "WBGene00009128", "Q9GYS9", "WBGene00020348", "Q7YX52", "WBGene00008459", "Q9XX18", "WBGene00012645", "Q22438", "WBGene00011740", "Q6A575", "WBGene00023422", "Q7YWY8", "WBGene00010783", "O18199", "WBGene00013004", "WBGene00020625", "P91478", "WBGene00020625", "Q93425", "WBGene00008452", "Q9U3Q0", "WBGene00007564", "O61791", "WBGene00020037", "P34748", "WBGene00014224", "Q95Q11", "WBGene00013324", "Q688C0", "WBGene00023487", "P34388", "WBGene00017319", "Q9N361", "WBGene00021920", "Q95QS3", "WBGene00016412", "Q9XWV5", "WBGene00012556", "G5ECC9", "WBGene00010766", "Q22470", "WBGene00011759", "Q22483", "WBGene00020499", "Q9XWP0", "WBGene00012830", "G5EC67", "WBGene00013210", "Q23155", "WBGene00012244", "Q9XTY5", "WBGene00011391", "O61818", "WBGene00044321", "O44133", "WBGene00016057", "Q09261", "WBGene00007859", "G5EFC8", "WBGene00000933", "P49391", "WBGene00011334", "Q9NAP9", "WBGene00010624", "Q19685", "WBGene00009013", "Q9N584", "WBGene00002804", "Q21601", "WBGene00010905", "Q10129", "WBGene00018961", "O17004", "WBGene00020718", "Q11189", "WBGene00015487", "Q9NEI6", "WBGene00012697", "Q09523", "WBGene00008456", "Q9GYI2", "WBGene00017924", "Q21454", "WBGene00010812", "O02207", "WBGene00007215", "Q04907", "WBGene00016249", "Q95QC2", "WBGene00019838", "Q9UA63", "WBGene00021021", "P34384", "WBGene00008514", "Q9BPN6", "WBGene00022373", "O02220", "WBGene00007712", "Q95QL2", "WBGene00008769", "A0A1N7SYX2", "WBGene00003066", "O18180", "WBGene00012361", "P90993", "WBGene00015185", "P34264", "WBGene00015133", "Q9TZ90", "WBGene00018793", "Q21083", "WBGene00010458", "O17005", "WBGene00020717", "Q7KPW7", "WBGene00017997", "Q4W5T0", "WBGene00044344", "Q22623", "WBGene00011883", "Q9NAG2", "WBGene00012992", "Q21939", "WBGene00011247", "O45110", "WBGene00018932", "O44159", "WBGene00016989", "Q95Y83", "WBGene00022470", "Q2L6V2", "WBGene00015092", "P34378", "WBGene00017044", "C0VXV6", "WBGene00021935", "Q9N3F3", "WBGene00021829", "Q95Y71", "WBGene00022493", "Q22140", "WBGene00011412", "P90915", "WBGene00010616", "P49404", "WBGene00016142", "Q95X39", "WBGene00015025", "O76606", "WBGene00020796", "Q9TYJ8", "WBGene00022045", "P91353", "WBGene00019076", "O17839", "WBGene00009128", "Q9GYS9", "WBGene00020348", "Q7YX52", "WBGene00008459", "Q9XX18", "WBGene00012645", "Q22438", "WBGene00011740", "Q6A575", "WBGene00023422", "Q7YWY8", "WBGene00010783", "O18199", "WBGene00013004" ] }, "reaction_10552302": { "compartment": "compartment_5460", "id": "reaction_10552302", "reactome": "R-CEL-5419264", "name": "MTRF1L (MTRF1a) or ICT1 binds stop codon in 55S ribosome:mRNA:peptidyl-tRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10552298", "species_113573", "species_10552289" ], "products": [ "species_10552300" ], "modifiers": [], "additional_components": [ "O44568", "WBGene00020993", "Q95QC2", "WBGene00019838", "Q93425", "WBGene00008452", "Q9U3Q0", "WBGene00007564", "O61791", "WBGene00020037", "P34748", "WBGene00014224", "Q95Q11", "WBGene00013324", "Q688C0", "WBGene00023487", "P34388", "WBGene00017319", "Q9N361", "WBGene00021920", "Q95QS3", "WBGene00016412", "Q9XWV5", "WBGene00012556", "G5ECC9", "WBGene00010766", "Q22470", "WBGene00011759", "Q22483", "WBGene00020499", "Q9XWP0", "WBGene00012830", "G5EC67", "WBGene00013210", "Q23155", "WBGene00012244", "Q9XTY5", "WBGene00011391", "O61818", "WBGene00044321", "O44133", "WBGene00016057", "Q09261", "WBGene00007859", "G5EFC8", "WBGene00000933", "P49391", "WBGene00011334", "Q9NAP9", "WBGene00010624", "Q19685", "WBGene00009013", "Q9N584", "WBGene00002804", "Q21601", "WBGene00010905", "Q10129", "WBGene00018961", "O17004", "WBGene00020718", "Q11189", "WBGene00015487", "Q9NEI6", "WBGene00012697", "Q09523", "WBGene00008456", "Q9GYI2", "WBGene00017924", "Q21454", "WBGene00010812", "O02207", "WBGene00007215", "Q04907", "WBGene00016249", "Q95QC2", "WBGene00019838", "Q9UA63", "WBGene00021021", "P34384", "WBGene00008514", "Q9BPN6", "WBGene00022373", "O02220", "WBGene00007712", "Q95QL2", "WBGene00008769", "A0A1N7SYX2", "WBGene00003066", "O18180", "WBGene00012361", "P90993", "WBGene00015185", "P34264", "WBGene00015133", "Q9TZ90", "WBGene00018793", "Q21083", "WBGene00010458", "O17005", "WBGene00020717", "Q7KPW7", "WBGene00017997", "Q4W5T0", "WBGene00044344", "Q22623", "WBGene00011883", "Q9NAG2", "WBGene00012992", "Q21939", "WBGene00011247", "O45110", "WBGene00018932", "O44159", "WBGene00016989", "Q95Y83", "WBGene00022470", "Q2L6V2", "WBGene00015092", "P34378", "WBGene00017044", "C0VXV6", "WBGene00021935", "Q9N3F3", "WBGene00021829", "Q95Y71", "WBGene00022493", "Q22140", "WBGene00011412", "P90915", "WBGene00010616", "P49404", "WBGene00016142", "Q95X39", "WBGene00015025", "O76606", "WBGene00020796", "Q9TYJ8", "WBGene00022045", "P91353", "WBGene00019076", "O17839", "WBGene00009128", "Q9GYS9", "WBGene00020348", "Q7YX52", "WBGene00008459", "Q9XX18", "WBGene00012645", "Q22438", "WBGene00011740", "Q6A575", "WBGene00023422", "Q7YWY8", "WBGene00010783", "O18199", "WBGene00013004", "Q93425", "WBGene00008452", "Q9U3Q0", "WBGene00007564", "O61791", "WBGene00020037", "P34748", "WBGene00014224", "Q95Q11", "WBGene00013324", "Q688C0", "WBGene00023487", "P34388", "WBGene00017319", "Q9N361", "WBGene00021920", "Q95QS3", "WBGene00016412", "Q9XWV5", "WBGene00012556", "G5ECC9", "WBGene00010766", "Q22470", "WBGene00011759", "Q22483", "WBGene00020499", "Q9XWP0", "WBGene00012830", "G5EC67", "WBGene00013210", "Q23155", "WBGene00012244", "Q9XTY5", "WBGene00011391", "O61818", "WBGene00044321", "O44133", "WBGene00016057", "Q09261", "WBGene00007859", "G5EFC8", "WBGene00000933", "P49391", "WBGene00011334", "Q9NAP9", "WBGene00010624", "Q19685", "WBGene00009013", "Q9N584", "WBGene00002804", "Q21601", "WBGene00010905", "Q10129", "WBGene00018961", "O17004", "WBGene00020718", "Q11189", "WBGene00015487", "Q9NEI6", "WBGene00012697", "Q09523", "WBGene00008456", "Q9GYI2", "WBGene00017924", "Q21454", "WBGene00010812", "O02207", "WBGene00007215", "Q04907", "WBGene00016249", "Q95QC2", "WBGene00019838", "Q9UA63", "WBGene00021021", "P34384", "WBGene00008514", "Q9BPN6", "WBGene00022373", "O02220", "WBGene00007712", "Q95QL2", "WBGene00008769", "A0A1N7SYX2", "WBGene00003066", "O18180", "WBGene00012361", "P90993", "WBGene00015185", "P34264", "WBGene00015133", "Q9TZ90", "WBGene00018793", "Q21083", "WBGene00010458", "O17005", "WBGene00020717", "Q7KPW7", "WBGene00017997", "Q4W5T0", "WBGene00044344", "Q22623", "WBGene00011883", "Q9NAG2", "WBGene00012992", "Q21939", "WBGene00011247", "O45110", "WBGene00018932", "O44159", "WBGene00016989", "Q95Y83", "WBGene00022470", "Q2L6V2", "WBGene00015092", "P34378", "WBGene00017044", "C0VXV6", "WBGene00021935", "Q9N3F3", "WBGene00021829", "Q95Y71", "WBGene00022493", "Q22140", "WBGene00011412", "P90915", "WBGene00010616", "P49404", "WBGene00016142", "Q95X39", "WBGene00015025", "O76606", "WBGene00020796", "Q9TYJ8", "WBGene00022045", "P91353", "WBGene00019076", "O17839", "WBGene00009128", "Q9GYS9", "WBGene00020348", "Q7YX52", "WBGene00008459", "Q9XX18", "WBGene00012645", "Q22438", "WBGene00011740", "Q6A575", "WBGene00023422", "Q7YWY8", "WBGene00010783", "O18199", "WBGene00013004", "species_29438", "O44568", "WBGene00020993" ] }, "reaction_10535860": { "compartment": "compartment_984", "id": "reaction_10535860", "reactome": "R-CEL-1602374", "name": "PS is hydrolyzed to 1-acyl LPS by PLA2[15]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_33625" ], "products": [ "species_1602419", "species_1602366" ], "modifiers": [ [ "species_10535837", "catalyst" ], [ "species_10535855", "inhibitor" ] ], "additional_components": [ "species_74016", "Q17790", "WBGene00044468", "O16654", "WBGene00044468", "Q3V5J7", "WBGene00044468", "Q18339", "WBGene00016288", "G4RY15", "WBGene00015631", "P34472", "WBGene00010228", "Q22591", "WBGene00020585" ] }, "reaction_10534870": { "compartment": "compartment_12045", "id": "reaction_10534870", "reactome": "R-CEL-1482776", "name": "PS is hydrolyzed to 1-acyl LPS by PLA2G2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1500646" ], "products": [ "species_1524021", "species_1498724" ], "modifiers": [ [ "species_10534852", "catalyst" ] ], "additional_components": [ "Q3V5J7", "WBGene00044468", "O16654", "WBGene00044468", "Q17790", "WBGene00044468", "species_74016" ] }, "reaction_10534806": { "compartment": "compartment_12045", "id": "reaction_10534806", "reactome": "R-CEL-1482636", "name": "1-acyl LPS is acylated to PS by LPSAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500578", "species_1498724" ], "products": [ "species_76194", "species_1500646" ], "modifiers": [ [ "species_10534803", "catalyst" ] ], "additional_components": [ "G5EC53", "WBGene00016934", "H9G2W5", "WBGene00007446", "O01925", "WBGene00020115" ] }, "reaction_10566472": { "compartment": "compartment_12045", "id": "reaction_10566472", "reactome": "R-CEL-8867876", "name": "OSBPL5,8,10 exchange PS with PI4P from ER membrane to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_392417", "species_1500646" ], "products": [ "species_33625", "species_1806234" ], "modifiers": [ [ "species_10566469", "catalyst" ] ], "additional_components": [ "WBGene00014215" ] }, "reaction_10534861": { "compartment": "compartment_12045", "id": "reaction_10534861", "reactome": "R-CEL-1482691", "name": "2-acyl LPS is acylated to PS by LPSAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500578", "species_1498722" ], "products": [ "species_76194", "species_1500646" ], "modifiers": [ [ "species_10534803", "catalyst" ] ], "additional_components": [ "G5EC53", "WBGene00016934", "H9G2W5", "WBGene00007446", "O01925", "WBGene00020115" ] }, "reaction_10570607": { "compartment": "compartment_5460", "id": "reaction_10570607", "reactome": "R-CEL-8986181", "name": "PITRM1 proteolyzes mitochondrial targeting peptides (presequences)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10570599" ], "products": [], "modifiers": [ [ "species_10570604", "catalyst" ] ], "additional_components": [ "Q9XWJ5", "WBGene00013094", "WBGene00011679" ] }, "reaction_10529207": { "compartment": "compartment_876", "id": "reaction_10529207", "reactome": "R-CEL-917870", "name": "SLC46A1 transports hemes from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9707310" ], "products": [ "species_9707308" ], "modifiers": [ [ "species_10514650", "catalyst" ] ], "additional_components": [ "species_71185", "Q9UAZ6", "WBGene00021159", "Q9XWL3", "WBGene00012811", "H2KZC0", "WBGene00016705", "Q20236", "WBGene00009582" ] }, "reaction_10532366": { "compartment": "compartment_70101", "id": "reaction_10532366", "reactome": "R-CEL-1247960", "name": "Activation of p38 MAPK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10532355" ], "products": [ "species_10532363", "species_29370" ], "modifiers": [ [ "species_10525519", "catalyst" ] ], "additional_components": [ "WBGene00004758" ] }, "reaction_10532487": { "compartment": "compartment_70101", "id": "reaction_10532487", "reactome": "R-CEL-1250264", "name": "TXNIP binds reduced thioredoxin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10532483", "species_10506160" ], "products": [ "species_10532485" ], "modifiers": [], "additional_components": [ "P91469", "WBGene00020612", "Q9XXN6", "WBGene00009000", "O17982", "WBGene00011054", "Q9GYT5", "WBGene00018060", "Q20577", "WBGene00009852", "O17983", "WBGene00011055", "Q9TYQ0", "WBGene00019873", "Q21550", "WBGene00006429", "O44847", "WBGene00020205", "Q9XTU0", "WBGene00013043", "Q22321", "WBGene00020323", "O45782", "WBGene00011732", "Q9XXC4", "WBGene00013086", "D1MN74", "WBGene00009579", "Q23672", "WBGene00014159", "O62274", "WBGene00010268", "Q9XXI0", "WBGene00012467", "O17812", "WBGene00008843", "Q23674", "WBGene00014161", "P30647", "WBGene00014033", "Q9XXI4", "WBGene00012464", "O17981", "WBGene00011052", "Q9GYT4", "WBGene00018061", "WBGene00015062", "Q09433", "WBGene00015062", "P91469", "WBGene00020612", "Q9XXN6", "WBGene00009000", "O17982", "WBGene00011054", "Q9GYT5", "WBGene00018060", "Q20577", "WBGene00009852", "O17983", "WBGene00011055", "Q9TYQ0", "WBGene00019873", "Q21550", "WBGene00006429", "O44847", "WBGene00020205", "Q9XTU0", "WBGene00013043", "Q22321", "WBGene00020323", "O45782", "WBGene00011732", "Q9XXC4", "WBGene00013086", "D1MN74", "WBGene00009579", "Q23672", "WBGene00014159", "O62274", "WBGene00010268", "Q9XXI0", "WBGene00012467", "O17812", "WBGene00008843", "Q23674", "WBGene00014161", "P30647", "WBGene00014033", "Q9XXI4", "WBGene00012464", "O17981", "WBGene00011052", "Q9GYT4", "WBGene00018061" ] }, "reaction_10532489": { "compartment": "compartment_70101", "id": "reaction_10532489", "reactome": "R-CEL-1250280", "name": "ROS oxidize thioredoxin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10506160", "species_1250243" ], "products": [ "species_10506158" ], "modifiers": [], "additional_components": [ "WBGene00015062", "WBGene00015062" ] }, "reaction_10571508": { "compartment": "compartment_7660", "id": "reaction_10571508", "reactome": "R-CEL-9021357", "name": "PRKCI phosphorylates ELF3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10571503" ], "products": [ "species_113582", "species_10571503" ], "modifiers": [ [ "species_10571505", "catalyst" ] ], "additional_components": [ "WBGene00006462", "WBGene00006462", "WBGene00004034" ] }, "reaction_10538172": { "compartment": "compartment_70101", "id": "reaction_10538172", "reactome": "R-CEL-1912382", "name": "Mature NOTCH heterodimer traffics to the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10538156" ], "products": [ "species_10538165" ], "modifiers": [ [ "species_10538170", "inhibitor" ] ], "additional_components": [ "Q21850", "WBGene00019957", "Q21850", "WBGene00019957", "WBGene00004766" ] }, "reaction_10532496": { "compartment": "compartment_876", "id": "reaction_10532496", "reactome": "R-CEL-1250370", "name": "Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10532493", "catalyst" ] ], "additional_components": [ "G5EDP9", "WBGene00000001", "Q94125", "WBGene00000090" ] }, "reaction_10532624": { "compartment": "compartment_70101", "id": "reaction_10532624", "reactome": "R-CEL-1253343", "name": "WWOX binds ERBB4s80", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10532620", "species_10532532" ], "products": [ "species_10532622" ], "modifiers": [], "additional_components": [ "WBGene00000971", "P24348", "WBGene00002299", "P24348", "WBGene00002299", "Q19062", "WBGene00000971" ] }, "reaction_10532677": { "compartment": "compartment_70101", "id": "reaction_10532677", "reactome": "R-CEL-1254376", "name": "Translocation of cytosolic ERBB4s80 to mitochondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10532532" ], "products": [ "species_10532675" ], "modifiers": [], "additional_components": [ "P24348", "WBGene00002299", "P24348", "WBGene00002299" ] }, "reaction_10532663": { "compartment": "compartment_70101", "id": "reaction_10532663", "reactome": "R-CEL-1254285", "name": "ERBB4s80:STAT5A complex translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10532651" ], "products": [ "species_10532661" ], "modifiers": [], "additional_components": [ "P24348", "WBGene00002299", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "P24348", "WBGene00002299" ] }, "reaction_10532665": { "compartment": "compartment_70101", "id": "reaction_10532665", "reactome": "R-CEL-1254291", "name": "ERBB4s80 binds STAT5A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10532649", "species_10532532" ], "products": [ "species_10532651" ], "modifiers": [], "additional_components": [ "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "P24348", "WBGene00002299", "P24348", "WBGene00002299", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111" ] }, "reaction_10532603": { "compartment": "compartment_70101", "id": "reaction_10532603", "reactome": "R-CEL-1252013", "name": "Translocation of ERBB4s80 to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10532532" ], "products": [ "species_10532599" ], "modifiers": [ [ "species_10532601", "inhibitor" ] ], "additional_components": [ "P24348", "WBGene00002299", "P24348", "WBGene00002299", "P24348", "WBGene00002299", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635" ] }, "reaction_10532589": { "compartment": "compartment_70101", "id": "reaction_10532589", "reactome": "R-CEL-1251997", "name": "Cleavage of ERBB4m80 by gamma-scretase complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10532522" ], "products": [ "species_10532532" ], "modifiers": [ [ "species_10532586", "catalyst" ] ], "additional_components": [ "P24348", "WBGene00002299", "P24348", "WBGene00002299", "Q23316", "WBGene00000148", "P52166", "WBGene00004769", "Q01608", "WBGene00004958", "O02100", "WBGene00001985", "Q9U357", "WBGene00003975", "O45876", "WBGene00000147" ] }, "reaction_10532637": { "compartment": "compartment_70101", "id": "reaction_10532637", "reactome": "R-CEL-1254248", "name": "Translocation of ERBB4s80:YAP1 complex to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10532631" ], "products": [ "species_10532635" ], "modifiers": [], "additional_components": [ "P24348", "WBGene00002299", "Q19404", "WBGene00008748", "P24348", "WBGene00002299", "Q19404", "WBGene00008748" ] }, "reaction_10532639": { "compartment": "compartment_70101", "id": "reaction_10532639", "reactome": "R-CEL-1254251", "name": "ERBB4s80 binds YAP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10532629", "species_10532532" ], "products": [ "species_10532631" ], "modifiers": [], "additional_components": [ "WBGene00008748", "P24348", "WBGene00002299", "P24348", "WBGene00002299", "Q19404", "WBGene00008748" ] }, "reaction_10538338": { "compartment": "compartment_70101", "id": "reaction_10538338", "reactome": "R-CEL-1977296", "name": "NEDD4 ubiquitinates ERBB4jmAcyt1s80 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10538331", "species_10502375" ], "products": [ "species_10538335" ], "modifiers": [ [ "species_10538331", "catalyst" ] ], "additional_components": [ "A0A061ACQ8", "WBGene00022358", "P24348", "WBGene00002299", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "A0A061ACQ8", "WBGene00022358", "P24348", "WBGene00002299", "A0A061ACQ8", "WBGene00022358", "P24348", "WBGene00002299" ] }, "reaction_10532613": { "compartment": "compartment_70101", "id": "reaction_10532613", "reactome": "R-CEL-1253282", "name": "ERBB4 ubiquitination by WWP1/ITCH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502375", "species_10532608" ], "products": [ "species_10532610" ], "modifiers": [ [ "species_10532608", "catalyst" ] ], "additional_components": [ "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "Q9N2Z7", "WBGene00007009", "P24348", "WBGene00002299", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "Q9N2Z7", "WBGene00007009", "P24348", "WBGene00002299", "Q9N2Z7", "WBGene00007009", "P24348", "WBGene00002299" ] }, "reaction_10532615": { "compartment": "compartment_876", "id": "reaction_10532615", "reactome": "R-CEL-1253300", "name": "ERBB4 binds WWP1/ITCH ubiquitin ligases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10532606", "species_10530908" ], "products": [ "species_10532608" ], "modifiers": [], "additional_components": [ "P24348", "WBGene00002299", "WBGene00007009", "Q9N2Z7", "WBGene00007009", "P24348", "WBGene00002299" ] }, "reaction_10572102": { "compartment": "compartment_876", "id": "reaction_10572102", "reactome": "R-CEL-9612219", "name": "ERBB4s80 binds to SRC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10518187", "species_10532532" ], "products": [ "species_10532601" ], "modifiers": [], "additional_components": [ "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "P24348", "WBGene00002299", "P24348", "WBGene00002299", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635" ] }, "reaction_10538333": { "compartment": "compartment_70101", "id": "reaction_10538333", "reactome": "R-CEL-1973956", "name": "NEDD4 binds ERBB4jmAcyt1s80 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10532526", "species_10530876" ], "products": [ "species_10538331" ], "modifiers": [], "additional_components": [ "P24348", "WBGene00002299", "WBGene00022358", "A0A061ACQ8", "WBGene00022358", "P24348", "WBGene00002299" ] }, "reaction_10509830": { "compartment": "compartment_70101", "id": "reaction_10509830", "reactome": "R-CEL-141429", "name": "Inactivation of APC/C via CDC20 sequestration", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509819", "species_10509824" ], "products": [ "species_10509828" ], "modifiers": [], "additional_components": [ "WBGene00001511", "WBGene00003161", "Q9NGT3", "WBGene00003161", "Q09373", "WBGene00001511" ] }, "reaction_10509832": { "compartment": "compartment_70101", "id": "reaction_10509832", "reactome": "R-CEL-141437", "name": "Formation of the MCC complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509819", "species_10509814", "species_10509809", "species_10509824" ], "products": [ "species_10509826" ], "modifiers": [], "additional_components": [ "WBGene00001511", "WBGene00013209", "WBGene00000275", "WBGene00003161", "Q9NGT3", "WBGene00003161", "Q21776", "WBGene00000275", "Q9XWH0", "WBGene00013209", "Q09373", "WBGene00001511" ] }, "reaction_10511637": { "compartment": "compartment_7660", "id": "reaction_10511637", "reactome": "R-CEL-174251", "name": "Phosphorylation of Cdh1 by Cyclin B1:Cdc2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10511632" ], "products": [ "species_113582", "species_10511634" ], "modifiers": [ [ "species_10511241", "catalyst" ] ], "additional_components": [ "WBGene00001510", "WBGene00001510", "O45926", "WBGene00000866", "Q10653", "WBGene00000865", "Q9BLB5", "WBGene00000867", "P34556", "WBGene00000405" ] }, "reaction_10522739": { "compartment": "compartment_70101", "id": "reaction_10522739", "reactome": "R-CEL-426240", "name": "DAG kinase produces phosphatidic acid from DAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_114519" ], "products": [ "species_76108", "species_29370" ], "modifiers": [ [ "species_10522736", "catalyst" ] ], "additional_components": [ "Q03603", "WBGene00000960", "Q10024", "WBGene00019428", "H2KZC9", "WBGene00006483", "H2KYI9", "WBGene00000959", "Q17860", "WBGene00000958" ] }, "reaction_10509684": { "compartment": "compartment_114521", "id": "reaction_10509684", "reactome": "R-CEL-139854", "name": "IP3R tetramer:I(1,4,5)P3:4xCa2+ transports Ca2+ from platelet dense tubular system to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_139827" ], "products": [ "species_74016" ], "modifiers": [ [ "species_10509681", "catalyst" ] ], "additional_components": [ "species_114520", "species_74016", "Q9Y0A1", "WBGene00002173" ] }, "reaction_10522615": { "compartment": "compartment_876", "id": "reaction_10522615", "reactome": "R-CEL-426032", "name": "DAG is metabolized by DAGL to 2-AG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_114519" ], "products": [ "species_426026", "species_426030" ], "modifiers": [ [ "species_10522612", "catalyst" ] ], "additional_components": [ "WBGene00018364" ] }, "reaction_10557468": { "compartment": "compartment_876", "id": "reaction_10557468", "reactome": "R-CEL-5694462", "name": "ABHD6,12 hydrolyse 3AG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_5694509" ], "products": [ "species_422506", "species_70106", "species_76116" ], "modifiers": [ [ "species_10557465", "catalyst" ] ], "additional_components": [ "WBGene00022393" ] }, "reaction_10509686": { "compartment": "compartment_70101", "id": "reaction_10509686", "reactome": "R-CEL-139941", "name": "Binding of IP3 to IP3 receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509679", "species_114520" ], "products": [ "species_10509681" ], "modifiers": [], "additional_components": [ "Q9Y0A1", "WBGene00002173", "species_114520", "species_74016", "Q9Y0A1", "WBGene00002173" ] }, "reaction_10522696": { "compartment": "compartment_876", "id": "reaction_10522696", "reactome": "R-CEL-426209", "name": "DAG activation of TRPC channels", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_114519", "species_10522688" ], "products": [ "species_10522694" ], "modifiers": [], "additional_components": [ "WBGene00006615", "Q8I6Y9", "WBGene00006615", "species_114519" ] }, "reaction_10522510": { "compartment": "compartment_70101", "id": "reaction_10522510", "reactome": "R-CEL-425861", "name": "Activation of Protein Kinase C novel isoforms", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_114519", "species_10513858" ], "products": [ "species_10522508" ], "modifiers": [], "additional_components": [ "P34885", "WBGene00004032", "P34722", "WBGene00006599", "P34885", "WBGene00004032", "P34722", "WBGene00006599", "species_114519" ] }, "reaction_10506679": { "compartment": "compartment_70101", "id": "reaction_10506679", "reactome": "R-CEL-74372", "name": "uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_83962", "species_500244" ], "products": [ "species_29372", "species_500430" ], "modifiers": [ [ "species_10506676", "catalyst" ] ], "additional_components": [ "CHEBI:28542", "species_112016", "CHEBI:16450", "CHEBI:16704", "Q23588", "WBGene00022817" ] }, "reaction_10508615": { "compartment": "compartment_70101", "id": "reaction_10508615", "reactome": "R-CEL-109903", "name": "cytidine or uridine + ATP => CMP or UMP + ADP [UCK2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_500759" ], "products": [ "species_500761", "species_29370" ], "modifiers": [ [ "species_10508612", "catalyst" ] ], "additional_components": [ "CHEBI:16704", "CHEBI:17562", "species_109395", "species_109402", "Q17413", "WBGene00007089" ] }, "reaction_10558281": { "compartment": "compartment_70101", "id": "reaction_10558281", "reactome": "R-CEL-6788295", "name": "HDHD1:Mg2+ dephosphorylates PURIDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_6788291" ], "products": [ "species_29372", "species_6788290" ], "modifiers": [ [ "species_10558278", "catalyst" ] ], "additional_components": [ "G5EG26", "WBGene00020113", "species_114632" ] }, "reaction_10506106": { "compartment": "compartment_70101", "id": "reaction_10506106", "reactome": "R-CEL-73599", "name": "cytidine or uridine + ATP => CMP or UMP + ADP [UCK1]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_500759" ], "products": [ "species_500761", "species_29370" ], "modifiers": [ [ "species_10506103", "catalyst" ] ], "additional_components": [ "CHEBI:16704", "CHEBI:17562", "species_109395", "species_109402", "Q17413", "WBGene00007089" ] }, "reaction_10569948": { "compartment": "compartment_70101", "id": "reaction_10569948", "reactome": "R-CEL-8954327", "name": "UCKL1 phosphorylates urindine, cytidine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_500759" ], "products": [ "species_500761", "species_29370" ], "modifiers": [ [ "species_10569945", "catalyst" ] ], "additional_components": [ "CHEBI:16704", "CHEBI:17562", "species_109395", "species_109402", "WBGene00008948" ] }, "reaction_10506142": { "compartment": "compartment_70101", "id": "reaction_10506142", "reactome": "R-CEL-73632", "name": "thymidine + ATP => TMP (deoxythymidine 5'-monophosphate) + ADP [TK1]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_83928" ], "products": [ "species_29370", "species_109366" ], "modifiers": [ [ "species_10506139", "catalyst" ] ], "additional_components": [ "G5EEZ5", "WBGene00006568" ] }, "reaction_10506126": { "compartment": "compartment_70101", "id": "reaction_10506126", "reactome": "R-CEL-73608", "name": "(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_500829" ], "products": [ "species_500430", "species_31633" ], "modifiers": [ [ "species_10506123", "catalyst" ] ], "additional_components": [ "CHEBI:15698", "CHEBI:17562", "CHEBI:16450", "CHEBI:16704", "species_216785", "Q20628", "WBGene00000392" ] }, "reaction_10509057": { "compartment": "compartment_70101", "id": "reaction_10509057", "reactome": "R-CEL-111966", "name": "GRK2 binds CALM1:4Ca2+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509037", "species_10508995" ], "products": [ "species_10509039" ], "modifiers": [ [ "species_10509055", "inhibitor" ] ], "additional_components": [ "WBGene00001709", "species_74016", "Q11083", "WBGene00020378", "P04630", "WBGene00000285", "G5EF37", "WBGene00003934", "A0A2C9C3L3", "WBGene00020378", "Q18136", "WBGene00006861", "Q09665", "WBGene00006583", "O02159", "WBGene00020378", "G5EDZ8", "WBGene00000288", "Q94288", "WBGene00000287", "Q09980", "WBGene00017394", "O16305", "WBGene00000552", "G5EEG0", "WBGene00000286", "species_74016", "Q11083", "WBGene00020378", "P04630", "WBGene00000285", "G5EF37", "WBGene00003934", "A0A2C9C3L3", "WBGene00020378", "Q18136", "WBGene00006861", "Q09665", "WBGene00006583", "O02159", "WBGene00020378", "G5EDZ8", "WBGene00000288", "Q94288", "WBGene00000287", "Q09980", "WBGene00017394", "O16305", "WBGene00000552", "G5EEG0", "WBGene00000286", "Q09639", "WBGene00001709", "species_74016", "P90980", "WBGene00004033", "P34722", "WBGene00006599" ] }, "reaction_10508962": { "compartment": "compartment_70101", "id": "reaction_10508962", "reactome": "R-CEL-111925", "name": "cAMP induces dissociation of inactive PKA tetramers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508958" ], "products": [ "species_10508954", "species_10508960" ], "modifiers": [], "additional_components": [ "species_30389", "P30625", "WBGene00002190", "P21137", "WBGene00002189", "WBGene00002189", "P30625", "WBGene00002190", "species_30389" ] }, "reaction_10508997": { "compartment": "compartment_876", "id": "reaction_10508997", "reactome": "R-CEL-111930", "name": "Adenylate cyclase produces cAMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592" ], "products": [ "species_111294", "species_30389" ], "modifiers": [ [ "species_10508992", "catalyst" ], [ "species_10508995", "catalyst" ] ], "additional_components": [ "species_114632", "Q19523", "WBGene00000068", "O16880", "WBGene00000069", "G5EE33", "WBGene00000070", "Q966F9", "WBGene00000071", "species_74016", "Q11083", "WBGene00020378", "P04630", "WBGene00000285", "G5EF37", "WBGene00003934", "A0A2C9C3L3", "WBGene00020378", "Q18136", "WBGene00006861", "Q09665", "WBGene00006583", "O02159", "WBGene00020378", "G5EDZ8", "WBGene00000288", "Q94288", "WBGene00000287", "Q09980", "WBGene00017394", "O16305", "WBGene00000552", "G5EEG0", "WBGene00000286" ] }, "reaction_10569054": { "compartment": "compartment_70101", "id": "reaction_10569054", "reactome": "R-CEL-8951727", "name": "cAMP binds PKA tetramer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508956", "species_30389" ], "products": [ "species_10508958" ], "modifiers": [], "additional_components": [ "P30625", "WBGene00002190", "P21137", "WBGene00002189", "species_30389", "P30625", "WBGene00002190", "P21137", "WBGene00002189" ] }, "reaction_10509064": { "compartment": "compartment_876", "id": "reaction_10509064", "reactome": "R-CEL-111970", "name": "PKC phosphorylates GRK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509037", "species_113592" ], "products": [ "species_29370", "species_10509061" ], "modifiers": [ [ "species_10509055", "catalyst" ] ], "additional_components": [ "WBGene00001709", "WBGene00001709", "species_74016", "P90980", "WBGene00004033", "P34722", "WBGene00006599" ] }, "reaction_10524537": { "compartment": "compartment_70101", "id": "reaction_10524537", "reactome": "R-CEL-442749", "name": "CaMKK autophosphorylates in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10524529" ], "products": [ "species_113582", "species_10524534" ], "modifiers": [ [ "species_10524529", "catalyst" ] ], "additional_components": [ "species_74016", "A0A2C9C3L3", "WBGene00020378", "Q09980", "WBGene00017394", "G5EDZ8", "WBGene00000288", "Q11083", "WBGene00020378", "G5EEG0", "WBGene00000286", "Q18136", "WBGene00006861", "G5EF37", "WBGene00003934", "Q94288", "WBGene00000287", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "P04630", "WBGene00000285", "Q09665", "WBGene00006583", "Q3Y416", "WBGene00000518", "Q3Y416", "WBGene00000518", "species_74016", "A0A2C9C3L3", "WBGene00020378", "Q09980", "WBGene00017394", "G5EDZ8", "WBGene00000288", "Q11083", "WBGene00020378", "G5EEG0", "WBGene00000286", "Q18136", "WBGene00006861", "G5EF37", "WBGene00003934", "Q94288", "WBGene00000287", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "P04630", "WBGene00000285", "Q09665", "WBGene00006583", "species_74016", "A0A2C9C3L3", "WBGene00020378", "Q09980", "WBGene00017394", "G5EDZ8", "WBGene00000288", "Q11083", "WBGene00020378", "G5EEG0", "WBGene00000286", "Q18136", "WBGene00006861", "G5EF37", "WBGene00003934", "Q94288", "WBGene00000287", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "P04630", "WBGene00000285", "Q09665", "WBGene00006583", "Q3Y416", "WBGene00000518" ] }, "reaction_10509018": { "compartment": "compartment_70101", "id": "reaction_10509018", "reactome": "R-CEL-111955", "name": "cAMP hydrolysis by Cam-PDE 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_30389" ], "products": [ "species_76577" ], "modifiers": [ [ "species_10509015", "catalyst" ] ], "additional_components": [ "O18696", "WBGene00011433" ] }, "reaction_10509020": { "compartment": "compartment_70101", "id": "reaction_10509020", "reactome": "R-CEL-111956", "name": "Calmodulin activates Cam-PDE 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509015" ], "products": [ "species_10509015" ], "modifiers": [ [ "species_10508995", "catalyst" ] ], "additional_components": [ "O18696", "WBGene00011433", "O18696", "WBGene00011433", "species_74016", "Q11083", "WBGene00020378", "P04630", "WBGene00000285", "G5EF37", "WBGene00003934", "A0A2C9C3L3", "WBGene00020378", "Q18136", "WBGene00006861", "Q09665", "WBGene00006583", "O02159", "WBGene00020378", "G5EDZ8", "WBGene00000288", "Q94288", "WBGene00000287", "Q09980", "WBGene00017394", "O16305", "WBGene00000552", "G5EEG0", "WBGene00000286" ] }, "reaction_10562897": { "compartment": "compartment_876", "id": "reaction_10562897", "reactome": "R-CEL-6801101", "name": "RABGGTA binds RABGGTB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10562893", "species_10562888" ], "products": [ "species_10562895" ], "modifiers": [], "additional_components": [ "WBGene00015099", "WBGene00019778", "Q9TYY0", "WBGene00019778", "P41992", "WBGene00015099" ] }, "reaction_10562906": { "compartment": "compartment_70101", "id": "reaction_10562906", "reactome": "R-CEL-6801109", "name": "CHM binds RGGT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10562895", "species_10562902" ], "products": [ "species_10562904" ], "modifiers": [], "additional_components": [ "Q9TYY0", "WBGene00019778", "P41992", "WBGene00015099", "WBGene00022051", "Q9BKQ5", "WBGene00022051", "Q9TYY0", "WBGene00019778", "P41992", "WBGene00015099" ] }, "reaction_10562850": { "compartment": "compartment_70101", "id": "reaction_10562850", "reactome": "R-CEL-6800793", "name": "PIDD1 translocates to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10562842" ], "products": [ "species_10562848" ], "modifiers": [], "additional_components": [ "Q09564", "WBGene00009647", "Q17989", "WBGene00015779", "Q09564", "WBGene00009647", "Q17989", "WBGene00015779" ] }, "reaction_10563082": { "compartment": "compartment_7660", "id": "reaction_10563082", "reactome": "R-CEL-6805061", "name": "CK2 binds FACT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10563078", "species_10509283" ], "products": [ "species_10563080" ], "modifiers": [], "additional_components": [ "P18334", "WBGene00002191", "P28548", "WBGene00002196", "Q9N5R9", "WBGene00018849", "P41848", "WBGene00001974", "Q9N5R9", "WBGene00018849", "P41848", "WBGene00001974", "P18334", "WBGene00002191", "P28548", "WBGene00002196" ] }, "reaction_10567715": { "compartment": "compartment_7660", "id": "reaction_10567715", "reactome": "R-CEL-8877692", "name": "PIN1 binds phosphorylated PIP4K2B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10567708", "species_10529334" ], "products": [ "species_10567713" ], "modifiers": [], "additional_components": [ "Q9BL73", "WBGene00004088", "WBGene00022448", "Q9N492", "WBGene00022448", "Q9BL73", "WBGene00004088" ] }, "reaction_10567711": { "compartment": "compartment_7660", "id": "reaction_10567711", "reactome": "R-CEL-8877691", "name": "MAP2K6 phosphorylates PIP4K2B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10567697" ], "products": [ "species_113582", "species_10567708" ], "modifiers": [ [ "species_10525531", "catalyst" ] ], "additional_components": [ "Q9BL73", "WBGene00004088", "Q9BL73", "WBGene00004088", "WBGene00004758" ] }, "reaction_10559206": { "compartment": "compartment_70101", "id": "reaction_10559206", "reactome": "R-CEL-6795290", "name": "TORC2 complex phosphorylates SGK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10545420", "species_113592" ], "products": [ "species_29370", "species_10559204" ], "modifiers": [ [ "species_10513953", "catalyst" ] ], "additional_components": [ "WBGene00004789", "WBGene00004789", "P91040", "WBGene00015697", "Q95Q95", "WBGene00002583", "G5EFN2", "WBGene00009245", "Q9NA80", "WBGene00013261" ] }, "reaction_10559211": { "compartment": "compartment_70101", "id": "reaction_10559211", "reactome": "R-CEL-6795473", "name": "PDPK1 phosphorylates SGK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10559204" ], "products": [ "species_29370", "species_10559209" ], "modifiers": [ [ "species_10508530", "catalyst" ] ], "additional_components": [ "WBGene00004789", "WBGene00004789", "Q9UA62", "WBGene00021022", "species_179838" ] }, "reaction_10559312": { "compartment": "compartment_7660", "id": "reaction_10559312", "reactome": "R-CEL-6797616", "name": "CCNK:CDK12 binds RNA Pol II at DNA repair genes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10559292", "species_10559218" ], "products": [ "species_10559294" ], "modifiers": [], "additional_components": [ "Q9N5R9", "WBGene00018849", "P41848", "WBGene00001974", "Q9N554", "WBGene00021281", "H2KYV0", "WBGene00016115", "P52652", "WBGene00012000", "Q09413", "WBGene00010990", "Q9BKS1", "WBGene00001236", "G5ECR7", "WBGene00001235", "Q9TVL3", "WBGene00000410", "P34424", "WBGene00000508", "P34425", "WBGene00000507", "O17869", "WBGene00009650", "Q9TZ93", "WBGene00005014", "Q21338", "WBGene00005015", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q9XUM4", "WBGene00012236", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "P46551", "WBGene00007135", "O17869", "WBGene00009650", "P46551", "WBGene00007135", "O17869", "WBGene00009650", "Q9N5R9", "WBGene00018849", "P41848", "WBGene00001974", "Q9N554", "WBGene00021281", "H2KYV0", "WBGene00016115", "P52652", "WBGene00012000", "Q09413", "WBGene00010990", "Q9BKS1", "WBGene00001236", "G5ECR7", "WBGene00001235", "Q9TVL3", "WBGene00000410", "P34424", "WBGene00000508", "P34425", "WBGene00000507", "Q9TZ93", "WBGene00005014", "Q21338", "WBGene00005015", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q9XUM4", "WBGene00012236", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529" ] }, "reaction_10559220": { "compartment": "compartment_7660", "id": "reaction_10559220", "reactome": "R-CEL-6797090", "name": "CCNK binds CDK12", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509199", "species_10559216" ], "products": [ "species_10559218" ], "modifiers": [], "additional_components": [ "WBGene00009650", "WBGene00007135", "P46551", "WBGene00007135", "O17869", "WBGene00009650" ] }, "reaction_10559226": { "compartment": "compartment_7660", "id": "reaction_10559226", "reactome": "R-CEL-6797100", "name": "CCNK binds CDK13", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509199", "species_10559222" ], "products": [ "species_10559224" ], "modifiers": [], "additional_components": [ "WBGene00009650", "WBGene00007135", "P46551", "WBGene00007135", "O17869", "WBGene00009650" ] }, "reaction_10559310": { "compartment": "compartment_7660", "id": "reaction_10559310", "reactome": "R-CEL-6797606", "name": "CDK12 phosphorylates RNA Pol II CTD at DNA repair genes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10559294", "species_29358" ], "products": [ "species_113582", "species_10559307" ], "modifiers": [ [ "species_10559294", "catalyst" ] ], "additional_components": [ "P46551", "WBGene00007135", "O17869", "WBGene00009650", "Q9N5R9", "WBGene00018849", "P41848", "WBGene00001974", "Q9N554", "WBGene00021281", "H2KYV0", "WBGene00016115", "P52652", "WBGene00012000", "Q09413", "WBGene00010990", "Q9BKS1", "WBGene00001236", "G5ECR7", "WBGene00001235", "Q9TVL3", "WBGene00000410", "P34424", "WBGene00000508", "P34425", "WBGene00000507", "Q9TZ93", "WBGene00005014", "Q21338", "WBGene00005015", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q9XUM4", "WBGene00012236", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "P46551", "WBGene00007135", "O17869", "WBGene00009650", "Q9N5R9", "WBGene00018849", "P41848", "WBGene00001974", "Q9TVL3", "WBGene00000410", "P34424", "WBGene00000508", "P34425", "WBGene00000507", "Q9TZ93", "WBGene00005014", "Q21338", "WBGene00005015", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q9XUM4", "WBGene00012236", "Q9N554", "WBGene00021281", "H2KYV0", "WBGene00016115", "P52652", "WBGene00012000", "Q09413", "WBGene00010990", "Q9BKS1", "WBGene00001236", "G5ECR7", "WBGene00001235", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "P46551", "WBGene00007135", "O17869", "WBGene00009650", "Q9N5R9", "WBGene00018849", "P41848", "WBGene00001974", "Q9N554", "WBGene00021281", "H2KYV0", "WBGene00016115", "P52652", "WBGene00012000", "Q09413", "WBGene00010990", "Q9BKS1", "WBGene00001236", "G5ECR7", "WBGene00001235", "Q9TVL3", "WBGene00000410", "P34424", "WBGene00000508", "P34425", "WBGene00000507", "Q9TZ93", "WBGene00005014", "Q21338", "WBGene00005015", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q9XUM4", "WBGene00012236", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529" ] }, "reaction_10547457": { "compartment": "compartment_70101", "id": "reaction_10547457", "reactome": "R-CEL-3341343", "name": "PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10506160", "species_29408" ], "products": [ "species_10506158", "species_29356" ], "modifiers": [ [ "species_10547454", "catalyst" ] ], "additional_components": [ "WBGene00015062", "WBGene00015062", "A0A0K3AUJ9", "F09E5.15c" ] }, "reaction_10503060": { "compartment": "compartment_70101", "id": "reaction_10503060", "reactome": "R-CEL-70475", "name": "D-fructose 6-phosphate <=> alpha-D-Glucose 6-phosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29512" ], "products": [ "species_30537" ], "modifiers": [ [ "species_10503055", "catalyst" ] ], "additional_components": [ "Q7K707", "WBGene00013597" ] }, "reaction_10504231": { "compartment": "compartment_70101", "id": "reaction_10504231", "reactome": "R-CEL-71682", "name": "glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_111745" ], "products": [ "species_29450", "species_29366" ], "modifiers": [ [ "species_10504228", "catalyst" ] ], "additional_components": [ "Q93379", "WBGene00008117", "species_113596" ] }, "reaction_10502920": { "compartment": "compartment_70101", "id": "reaction_10502920", "reactome": "R-CEL-70377", "name": "alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30537", "species_29366" ], "products": [ "species_70106", "species_31467", "species_29364" ], "modifiers": [ [ "species_10502917", "catalyst" ] ], "additional_components": [ "species_29366", "Q27464", "WBGene00007108" ] }, "reaction_10506170": { "compartment": "compartment_70101", "id": "reaction_10506170", "reactome": "R-CEL-73646", "name": "thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10506158", "species_70106", "species_29364" ], "products": [ "species_29366", "species_10506160" ], "modifiers": [ [ "species_10506167", "catalyst" ] ], "additional_components": [ "WBGene00015062", "WBGene00015062", "Q17745", "WBGene00015553", "species_113596" ] }, "reaction_10553994": { "compartment": "compartment_70101", "id": "reaction_10553994", "reactome": "R-CEL-5631903", "name": "SESN1,2,3 bind overoxidized PRDX1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10553978", "species_10553986" ], "products": [ "species_10553992" ], "modifiers": [], "additional_components": [ "A0A0K3AUJ9", "F09E5.15c", "WBGene00022279", "Q9N4D6", "WBGene00022279", "A0A0K3AUJ9", "F09E5.15c" ] }, "reaction_10553981": { "compartment": "compartment_70101", "id": "reaction_10553981", "reactome": "R-CEL-5631885", "name": "PRDX1 overoxidizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10547448", "species_29408" ], "products": [ "species_29356", "species_10553978" ], "modifiers": [ [ "species_10547448", "catalyst" ] ], "additional_components": [ "A0A0K3AUJ9", "F09E5.15c", "A0A0K3AUJ9", "F09E5.15c", "A0A0K3AUJ9", "F09E5.15c" ] }, "reaction_10519966": { "compartment": "compartment_70101", "id": "reaction_10519966", "reactome": "R-CEL-380979", "name": "RHEB in mTORC1:RHEB:GTP hydrolyses GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10510588" ], "products": [ "species_29372", "species_10519963" ], "modifiers": [ [ "species_10510588", "catalyst" ] ], "additional_components": [ "Q19425", "WBGene00008774", "species_29420", "G5EGB3", "WBGene00012497", "Q22743", "WBGene00006414", "species_29438", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "P91040", "WBGene00015697", "Q95Q95", "WBGene00002583", "Q68TI8", "WBGene00000911", "P34443", "WBGene00010038", "P34443", "WBGene00010038", "species_29420", "Q19425", "WBGene00008774", "G5EGB3", "WBGene00012497", "Q22743", "WBGene00006414", "species_29438", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "P91040", "WBGene00015697", "Q95Q95", "WBGene00002583", "Q68TI8", "WBGene00000911", "Q19425", "WBGene00008774", "species_29420", "G5EGB3", "WBGene00012497", "Q22743", "WBGene00006414", "species_29438", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "P91040", "WBGene00015697", "Q95Q95", "WBGene00002583", "Q68TI8", "WBGene00000911", "P34443", "WBGene00010038" ] }, "reaction_10553998": { "compartment": "compartment_70101", "id": "reaction_10553998", "reactome": "R-CEL-5631941", "name": "SESN1,2,3 bind AMPK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10553986", "species_10519954" ], "products": [ "species_10553996" ], "modifiers": [], "additional_components": [ "WBGene00022279", "species_76577", "Q9XUY2", "WBGene00010115", "P45894", "WBGene00019801", "Q95ZQ4", "WBGene00020142", "A0A1T5HUK9", "WBGene00013732", "H2L0K0", "WBGene00020135", "O02168", "WBGene00020633", "Q9N501", "WBGene00021527", "species_76577", "Q9XUY2", "WBGene00010115", "P45894", "WBGene00019801", "Q95ZQ4", "WBGene00020142", "A0A1T5HUK9", "WBGene00013732", "H2L0K0", "WBGene00020135", "O02168", "WBGene00020633", "Q9N501", "WBGene00021527", "Q9N4D6", "WBGene00022279" ] }, "reaction_10503263": { "compartment": "compartment_5460", "id": "reaction_10503263", "reactome": "R-CEL-70609", "name": "glutamine + H2O => glutamate + NH4+ [GLS]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113522", "species_113521" ], "products": [ "species_113561", "species_113552" ], "modifiers": [ [ "species_10503260", "catalyst" ] ], "additional_components": [ "U4PRW7", "WBGene00007480", "Q19013", "WBGene00008435", "Q93650", "WBGene00009271" ] }, "reaction_10563027": { "compartment": "compartment_70101", "id": "reaction_10563027", "reactome": "R-CEL-6803875", "name": "SFN dimer binds CDK1 and CCNB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10563023", "species_10507049" ], "products": [ "species_10563025" ], "modifiers": [], "additional_components": [ "Q10653", "WBGene00000865", "Q9BLB5", "WBGene00000867", "O45926", "WBGene00000866", "P34556", "WBGene00000405", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "Q10653", "WBGene00000865", "Q9BLB5", "WBGene00000867", "O45926", "WBGene00000866", "P34556", "WBGene00000405" ] }, "reaction_10563029": { "compartment": "compartment_70101", "id": "reaction_10563029", "reactome": "R-CEL-6803890", "name": "SFN dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10507047" ], "products": [ "species_10507049" ], "modifiers": [], "additional_components": [ "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "P41932", "WBGene00003920", "Q20655", "WBGene00001502" ] }, "reaction_10569796": { "compartment": "compartment_7660", "id": "reaction_10569796", "reactome": "R-CEL-8952996", "name": "E2F7 forms homodimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10569792" ], "products": [ "species_10569794" ], "modifiers": [], "additional_components": [ "WBGene00009899", "Q20619", "WBGene00009899" ] }, "reaction_10569802": { "compartment": "compartment_7660", "id": "reaction_10569802", "reactome": "R-CEL-8953013", "name": "E2F7 binds E2F8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10569798", "species_10569792" ], "products": [ "species_10569800" ], "modifiers": [], "additional_components": [ "WBGene00009899", "WBGene00009899", "Q20619", "WBGene00009899" ] }, "reaction_10569806": { "compartment": "compartment_7660", "id": "reaction_10569806", "reactome": "R-CEL-8953037", "name": "E2F8 forms homodimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10569798" ], "products": [ "species_10569804" ], "modifiers": [], "additional_components": [ "WBGene00009899", "Q20619", "WBGene00009899" ] }, "reaction_10517733": { "compartment": "compartment_984", "id": "reaction_10517733", "reactome": "R-CEL-265456", "name": "NPC1L1 inactivation by ezetimibe", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_265479", "species_10517729" ], "products": [ "species_10517731" ], "modifiers": [], "additional_components": [ "P34389", "WBGene00003562", "Q19127", "WBGene00003561", "P34389", "WBGene00003562", "Q19127", "WBGene00003561", "species_265479" ] }, "reaction_10569030": { "compartment": "compartment_70101", "id": "reaction_10569030", "reactome": "R-CEL-8950780", "name": "p-Y705-STAT3 binds p-Y693-STAT4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10568972", "species_10531883" ], "products": [ "species_10569014" ], "modifiers": [], "additional_components": [ "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111" ] }, "reaction_10569018": { "compartment": "compartment_70101", "id": "reaction_10569018", "reactome": "R-CEL-8950724", "name": "p-Y705-STAT3:p-Y693-STAT4 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10569014" ], "products": [ "species_10569016" ], "modifiers": [], "additional_components": [ "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111" ] }, "reaction_10520825": { "compartment": "compartment_984", "id": "reaction_10520825", "reactome": "R-CEL-390641", "name": "ADRA1A,B,D bind ADR,NAd", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10519575", "species_390627" ], "products": [ "species_10519581" ], "modifiers": [ [ "species_10520823", "catalyst" ], [ "species_10520821", "inhibitor" ] ], "additional_components": [ "WBGene00008890", "species_209794", "species_209789", "species_209794", "species_209789", "G5EBX8", "WBGene00008890", "G5EBX8", "WBGene00008890", "G5EBX8", "WBGene00008890" ] }, "reaction_10520831": { "compartment": "compartment_984", "id": "reaction_10520831", "reactome": "R-CEL-390663", "name": "ADRA2A,B,C bind ADR,NAd", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_390627", "species_10519747" ], "products": [ "species_10519749" ], "modifiers": [], "additional_components": [ "species_209794", "species_209789", "O02213", "WBGene00004777", "Q19084", "WBGene00017157", "O02213", "WBGene00004777", "Q19084", "WBGene00017157", "species_209794", "species_209789" ] }, "reaction_10512688": { "compartment": "compartment_7660", "id": "reaction_10512688", "reactome": "R-CEL-187959", "name": "Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10512672" ], "products": [ "species_113582", "species_10512685" ], "modifiers": [ [ "species_10512672", "catalyst" ] ], "additional_components": [ "O61847", "WBGene00019362", "A5HWA8", "WBGene00001162", "O61847", "WBGene00019362", "A5HWA8", "WBGene00001162", "O61847", "WBGene00019362", "A5HWA8", "WBGene00001162" ] }, "reaction_10512674": { "compartment": "compartment_7660", "id": "reaction_10512674", "reactome": "R-CEL-187937", "name": "Association of Cyclin A:phospho-Cdk2(Thr 160) with E2F1/E2F3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502089", "species_10502278" ], "products": [ "species_10512672" ], "modifiers": [], "additional_components": [ "WBGene00001162", "O61847", "WBGene00019362", "O61847", "WBGene00019362", "A5HWA8", "WBGene00001162" ] }, "reaction_10565857": { "compartment": "compartment_70101", "id": "reaction_10565857", "reactome": "R-CEL-8857925", "name": "Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10513555" ], "products": [ "species_10565838", "species_29370" ], "modifiers": [ [ "species_10565854", "catalyst" ], [ "species_1806240", "catalyst" ] ], "additional_components": [] }, "reaction_10537250": { "compartment": "compartment_876", "id": "reaction_10537250", "reactome": "R-CEL-1676082", "name": "PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_392417" ], "products": [ "species_29370", "species_179856" ], "modifiers": [ [ "species_10537051", "catalyst" ] ], "additional_components": [ "WBGene00004087" ] }, "reaction_10537082": { "compartment": "compartment_876", "id": "reaction_10537082", "reactome": "R-CEL-1675776", "name": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806240", "species_113592" ], "products": [ "species_29370", "species_179856" ], "modifiers": [ [ "species_10537079", "catalyst" ] ], "additional_components": [ "Q9BL73", "WBGene00004088" ] }, "reaction_10564090": { "compartment": "compartment_70101", "id": "reaction_10564090", "reactome": "R-CEL-6811504", "name": "AKT1 dephosphorylation by PP2A-B56-beta,gamma", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10513843" ], "products": [ "species_10520798", "species_29372" ], "modifiers": [ [ "species_10564085", "catalyst" ], [ "species_1806240", "inhibitor" ] ], "additional_components": [ "Q9XTG7", "WBGene00000103", "G4S4W1", "WBGene00016980", "Q17941", "WBGene00000102", "G4S4W1", "WBGene00016980", "Q17941", "WBGene00000102", "Q9XTG7", "WBGene00000103", "O18178", "WBGene00012348", "A9UJN4", "WBGene00007554" ] }, "reaction_10543901": { "compartment": "compartment_70101", "id": "reaction_10543901", "reactome": "R-CEL-2316434", "name": "PI3K phosphorylates PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10543898", "catalyst" ] ], "additional_components": [ "Q94125", "WBGene00000090", "G5EDP9", "WBGene00000001", "P29355", "WBGene00004774", "G5EDJ4", "WBGene00004928", "E6N0V1", "WBGene00018819", "species_29438", "Q03206", "ced-10", "Q94124", "WBGene00004287", "Q9BL44", "WBGene00022177", "Q9XVQ7", "WBGene00008711", "A0A486WY88", "WBGene00010631", "species_1254400", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "A0A1I6CMA1", "WBGene00020678", "G5EGT9", "WBGene00003007", "P24348", "WBGene00002299", "species_179838", "Q9N413", "WBGene00004249" ] }, "reaction_10513621": { "compartment": "compartment_70101", "id": "reaction_10513621", "reactome": "R-CEL-195283", "name": "Phosphorylation of phospho- (Ser45, Thr41) beta-catenin at Ser37 by GSK-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10513614", "species_113592" ], "products": [ "species_29370", "species_10513618" ], "modifiers": [ [ "species_10513614", "catalyst" ] ], "additional_components": [ "Q21227", "WBGene00000156", "Q9U2Q9", "WBGene00001746", "Q09595", "WBGene00010991", "Q93372", "WBGene00010991", "P42168", "WBGene00002202", "O62090", "WBGene00004202", "O44326", "WBGene00001979", "O44326", "WBGene00001979", "Q21227", "WBGene00000156", "Q9U2Q9", "WBGene00001746", "Q09595", "WBGene00010991", "Q93372", "WBGene00010991", "P42168", "WBGene00002202", "O62090", "WBGene00004202", "Q21227", "WBGene00000156", "Q9U2Q9", "WBGene00001746", "Q09595", "WBGene00010991", "Q93372", "WBGene00010991", "P42168", "WBGene00002202", "O62090", "WBGene00004202", "O44326", "WBGene00001979" ] }, "reaction_10513640": { "compartment": "compartment_70101", "id": "reaction_10513640", "reactome": "R-CEL-195318", "name": "Phosphorylation of beta-catenin at Ser45 by CK1 alpha", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10513635" ], "products": [ "species_29370", "species_10513625" ], "modifiers": [ [ "species_10513635", "catalyst" ] ], "additional_components": [ "O44326", "WBGene00001979", "Q21227", "WBGene00000156", "Q9U2Q9", "WBGene00001746", "Q09595", "WBGene00010991", "Q93372", "WBGene00010991", "P42168", "WBGene00002202", "O62090", "WBGene00004202", "Q21227", "WBGene00000156", "Q9U2Q9", "WBGene00001746", "Q09595", "WBGene00010991", "Q93372", "WBGene00010991", "P42168", "WBGene00002202", "O62090", "WBGene00004202", "O44326", "WBGene00001979", "O44326", "WBGene00001979", "Q21227", "WBGene00000156", "Q9U2Q9", "WBGene00001746", "Q09595", "WBGene00010991", "Q93372", "WBGene00010991", "P42168", "WBGene00002202", "O62090", "WBGene00004202" ] }, "reaction_10513628": { "compartment": "compartment_70101", "id": "reaction_10513628", "reactome": "R-CEL-195287", "name": "Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10513625" ], "products": [ "species_10513614", "species_29370" ], "modifiers": [ [ "species_10513625", "catalyst" ] ], "additional_components": [ "Q21227", "WBGene00000156", "Q9U2Q9", "WBGene00001746", "Q09595", "WBGene00010991", "Q93372", "WBGene00010991", "P42168", "WBGene00002202", "O62090", "WBGene00004202", "O44326", "WBGene00001979", "Q21227", "WBGene00000156", "Q9U2Q9", "WBGene00001746", "Q09595", "WBGene00010991", "Q93372", "WBGene00010991", "P42168", "WBGene00002202", "O62090", "WBGene00004202", "O44326", "WBGene00001979", "Q21227", "WBGene00000156", "Q9U2Q9", "WBGene00001746", "Q09595", "WBGene00010991", "Q93372", "WBGene00010991", "P42168", "WBGene00002202", "O62090", "WBGene00004202", "O44326", "WBGene00001979" ] }, "reaction_10513631": { "compartment": "compartment_70101", "id": "reaction_10513631", "reactome": "R-CEL-195300", "name": "Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10513618" ], "products": [ "species_10513598", "species_29370" ], "modifiers": [ [ "species_10513618", "catalyst" ] ], "additional_components": [ "O44326", "WBGene00001979", "Q21227", "WBGene00000156", "Q9U2Q9", "WBGene00001746", "Q09595", "WBGene00010991", "Q93372", "WBGene00010991", "P42168", "WBGene00002202", "O62090", "WBGene00004202", "Q21227", "WBGene00000156", "Q9U2Q9", "WBGene00001746", "Q09595", "WBGene00010991", "Q93372", "WBGene00010991", "P42168", "WBGene00002202", "O62090", "WBGene00004202", "O44326", "WBGene00001979", "O44326", "WBGene00001979", "Q21227", "WBGene00000156", "Q9U2Q9", "WBGene00001746", "Q09595", "WBGene00010991", "Q93372", "WBGene00010991", "P42168", "WBGene00002202", "O62090", "WBGene00004202" ] }, "reaction_10568784": { "compartment": "compartment_7660", "id": "reaction_10568784", "reactome": "R-CEL-8944349", "name": "TLE tetramers bind TCF/LEF at WNT promoters", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10547166", "species_10568780" ], "products": [ "species_10568782" ], "modifiers": [], "additional_components": [ "O02482", "WBGene00006773", "Q10666", "WBGene00004077", "Q10666", "WBGene00004077", "O02482", "WBGene00006773" ] }, "reaction_10549443": { "compartment": "compartment_7660", "id": "reaction_10549443", "reactome": "R-CEL-4641229", "name": "TLE oligomerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10547150" ], "products": [ "species_10547166" ], "modifiers": [], "additional_components": [ "WBGene00006773", "O02482", "WBGene00006773" ] }, "reaction_10551337": { "compartment": "compartment_7660", "id": "reaction_10551337", "reactome": "R-CEL-5334050", "name": "TCF7L2/TCF7L1 bind CTBP1 to repress WNT target genes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546301", "species_10547139" ], "products": [ "species_10551335" ], "modifiers": [], "additional_components": [ "WBGene00006424", "WBGene00004077", "Q10666", "WBGene00004077", "Q20595", "WBGene00006424" ] }, "reaction_10542756": { "compartment": "compartment_70101", "id": "reaction_10542756", "reactome": "R-CEL-2130279", "name": "Association of beta-catenin with the RBX1:SCF(beta-TrCP1) ubiquitin ligase complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10516333", "species_10513603" ], "products": [ "species_10542754" ], "modifiers": [], "additional_components": [ "G5ECU1", "WBGene00004807", "Q17389", "WBGene00000836", "Q23457", "WBGene00004320", "Q21227", "WBGene00000156", "Q9U2Q9", "WBGene00001746", "Q09595", "WBGene00010991", "Q93372", "WBGene00010991", "P42168", "WBGene00002202", "O62090", "WBGene00004202", "O44326", "WBGene00001979", "Q21227", "WBGene00000156", "Q9U2Q9", "WBGene00001746", "Q09595", "WBGene00010991", "Q93372", "WBGene00010991", "P42168", "WBGene00002202", "O62090", "WBGene00004202", "O44326", "WBGene00001979", "G5ECU1", "WBGene00004807", "Q17389", "WBGene00000836", "Q23457", "WBGene00004320" ] }, "reaction_10513637": { "compartment": "compartment_70101", "id": "reaction_10513637", "reactome": "R-CEL-195304", "name": "Association of beta-catenin with the destruction complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10513587", "species_10513633" ], "products": [ "species_10513635" ], "modifiers": [], "additional_components": [ "Q21227", "WBGene00000156", "Q9U2Q9", "WBGene00001746", "Q09595", "WBGene00010991", "Q93372", "WBGene00010991", "P42168", "WBGene00002202", "O62090", "WBGene00004202", "WBGene00001979", "O44326", "WBGene00001979", "Q21227", "WBGene00000156", "Q9U2Q9", "WBGene00001746", "Q09595", "WBGene00010991", "Q93372", "WBGene00010991", "P42168", "WBGene00002202", "O62090", "WBGene00004202" ] }, "reaction_10550824": { "compartment": "compartment_70101", "id": "reaction_10550824", "reactome": "R-CEL-5229343", "name": "AXIN is phosphorylated in the destruction complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10515030" ], "products": [ "species_29370", "species_10513587" ], "modifiers": [ [ "species_10515030", "catalyst" ] ], "additional_components": [ "Q21227", "WBGene00000156", "Q9U2Q9", "WBGene00001746", "Q09595", "WBGene00010991", "Q93372", "WBGene00010991", "P42168", "WBGene00002202", "O62090", "WBGene00004202", "Q21227", "WBGene00000156", "Q9U2Q9", "WBGene00001746", "Q09595", "WBGene00010991", "Q93372", "WBGene00010991", "P42168", "WBGene00002202", "O62090", "WBGene00004202", "Q21227", "WBGene00000156", "Q9U2Q9", "WBGene00001746", "Q09595", "WBGene00010991", "Q93372", "WBGene00010991", "P42168", "WBGene00002202", "O62090", "WBGene00004202" ] }, "reaction_10513608": { "compartment": "compartment_70101", "id": "reaction_10513608", "reactome": "R-CEL-195275", "name": "Phosphorylation of APC component of the destruction complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10513598", "species_113592" ], "products": [ "species_29370", "species_10513603" ], "modifiers": [ [ "species_10513598", "catalyst" ] ], "additional_components": [ "Q21227", "WBGene00000156", "Q9U2Q9", "WBGene00001746", "Q09595", "WBGene00010991", "Q93372", "WBGene00010991", "P42168", "WBGene00002202", "O62090", "WBGene00004202", "O44326", "WBGene00001979", "Q21227", "WBGene00000156", "Q9U2Q9", "WBGene00001746", "Q09595", "WBGene00010991", "Q93372", "WBGene00010991", "P42168", "WBGene00002202", "O62090", "WBGene00004202", "O44326", "WBGene00001979", "Q21227", "WBGene00000156", "Q9U2Q9", "WBGene00001746", "Q09595", "WBGene00010991", "Q93372", "WBGene00010991", "P42168", "WBGene00002202", "O62090", "WBGene00004202", "O44326", "WBGene00001979" ] }, "reaction_10513610": { "compartment": "compartment_70101", "id": "reaction_10513610", "reactome": "R-CEL-195280", "name": "Dissociation of beta-catenin from Axin and association of beta catenin with phospho-(20 aa) APC in the detruction complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10513603" ], "products": [ "species_10513603" ], "modifiers": [], "additional_components": [ "Q21227", "WBGene00000156", "Q9U2Q9", "WBGene00001746", "Q09595", "WBGene00010991", "Q93372", "WBGene00010991", "P42168", "WBGene00002202", "O62090", "WBGene00004202", "O44326", "WBGene00001979", "Q21227", "WBGene00000156", "Q9U2Q9", "WBGene00001746", "Q09595", "WBGene00010991", "Q93372", "WBGene00010991", "P42168", "WBGene00002202", "O62090", "WBGene00004202", "O44326", "WBGene00001979" ] }, "reaction_10542762": { "compartment": "compartment_70101", "id": "reaction_10542762", "reactome": "R-CEL-2130282", "name": "Degradation of ubiquitinated beta catenin by the proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10542758" ], "products": [ "species_10516333", "species_10542760", "species_10502375" ], "modifiers": [ [ "species_10502572", "catalyst" ] ], "additional_components": [ "Q21227", "WBGene00000156", "Q9U2Q9", "WBGene00001746", "Q09595", "WBGene00010991", "Q93372", "WBGene00010991", "P42168", "WBGene00002202", "O62090", "WBGene00004202", "O44326", "WBGene00001979", "G5ECU1", "WBGene00004807", "Q17389", "WBGene00000836", "Q23457", "WBGene00004320", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "G5ECU1", "WBGene00004807", "Q17389", "WBGene00000836", "Q23457", "WBGene00004320", "Q21227", "WBGene00000156", "Q9U2Q9", "WBGene00001746", "Q09595", "WBGene00010991", "Q93372", "WBGene00010991", "P42168", "WBGene00002202", "O62090", "WBGene00004202", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "P91477", "WBGene00003950", "Q95PZ7", "WBGene00013435", "Q18115", "WBGene00004459", "O62102", "WBGene00003948", "O17071", "WBGene00004504", "Q10920", "WBGene00016623", "P34286", "WBGene00003952", "Q9XTT9", "WBGene00004506", "Q23449", "WBGene00004468", "Q95005", "WBGene00003925", "P46502", "WBGene00004503", "O61792", "WBGene00004464", "O17586", "WBGene00003922", "O76371", "WBGene00004505", "Q20585", "WBGene00004463", "Q95008", "WBGene00003926", "Q18787", "WBGene00004501", "Q20058", "WBGene00009445", "Q9N599", "WBGene00003924", "O16368", "WBGene00004502", "O61742", "WBGene00004466", "Q09583", "WBGene00003928", "Q966I8", "WBGene00003947", "Q04908", "WBGene00004460", "Q9XUV0", "WBGene00003951", "Q27488", "WBGene00003923", "Q9GZH5", "WBGene00004458", "O44156", "WBGene00003927", "Q22253", "WBGene00004465", "O76577", "WBGene00004467", "P90868", "WBGene00003953", "Q19324", "WBGene00004461", "Q17971", "WBGene00007588", "Q23237", "WBGene00003949", "Q20938", "WBGene00004462" ] }, "reaction_10542764": { "compartment": "compartment_70101", "id": "reaction_10542764", "reactome": "R-CEL-2130286", "name": "Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502375", "species_10542754" ], "products": [ "species_10542758" ], "modifiers": [], "additional_components": [ "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "Q21227", "WBGene00000156", "Q9U2Q9", "WBGene00001746", "Q09595", "WBGene00010991", "Q93372", "WBGene00010991", "P42168", "WBGene00002202", "O62090", "WBGene00004202", "O44326", "WBGene00001979", "G5ECU1", "WBGene00004807", "Q17389", "WBGene00000836", "Q23457", "WBGene00004320", "Q21227", "WBGene00000156", "Q9U2Q9", "WBGene00001746", "Q09595", "WBGene00010991", "Q93372", "WBGene00010991", "P42168", "WBGene00002202", "O62090", "WBGene00004202", "O44326", "WBGene00001979", "G5ECU1", "WBGene00004807", "Q17389", "WBGene00000836", "Q23457", "WBGene00004320", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727" ] }, "reaction_10569984": { "compartment": "compartment_70101", "id": "reaction_10569984", "reactome": "R-CEL-8955760", "name": "PGM2L1:Mg2+ phosphorylates G6P to G1,6BP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30537", "species_29800" ], "products": [ "species_70106", "species_8955759", "species_29728" ], "modifiers": [ [ "species_10502853", "catalyst" ] ], "additional_components": [ "O45934", "WBGene00012803", "species_114632" ] }, "reaction_10504330": { "compartment": "compartment_70101", "id": "reaction_10504330", "reactome": "R-CEL-71802", "name": "D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_29512" ], "products": [ "species_29370", "species_30533" ], "modifiers": [ [ "species_10504327", "catalyst" ], [ "species_30533", "catalyst" ] ], "additional_components": [ "Q21122", "WBGene00019295", "Q9N590", "WBGene00022456" ] }, "reaction_10502842": { "compartment": "compartment_70101", "id": "reaction_10502842", "reactome": "R-CEL-70262", "name": "Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_30533" ], "products": [ "species_29372", "species_29512" ], "modifiers": [ [ "species_10502839", "catalyst" ] ], "additional_components": [ "Q9N590", "WBGene00022456", "Q21122", "WBGene00019295" ] }, "reaction_10504194": { "compartment": "compartment_70101", "id": "reaction_10504194", "reactome": "R-CEL-71660", "name": "2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30485" ], "products": [ "species_29356", "species_29492" ], "modifiers": [ [ "species_10503109", "catalyst" ] ], "additional_components": [ "Q27527", "WBGene00011884", "species_114632" ] }, "reaction_10557538": { "compartment": "compartment_12045", "id": "reaction_10557538", "reactome": "R-CEL-5696021", "name": "ADPGK:Mg2+ phosphorylates Glc to G6P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29370", "species_70113" ], "products": [ "species_30537", "species_76577" ], "modifiers": [ [ "species_10557535", "catalyst" ] ], "additional_components": [ "species_114632", "Q86S40", "WBGene00016810" ] }, "reaction_10504004": { "compartment": "compartment_70101", "id": "reaction_10504004", "reactome": "R-CEL-71496", "name": "D-fructose 1,6-bisphosphate <=> dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30014" ], "products": [ "species_29578", "species_75970" ], "modifiers": [ [ "species_10503999", "catalyst" ] ], "additional_components": [ "P54216", "WBGene00011474", "P46563", "WBGene00017166" ] }, "reaction_10503048": { "compartment": "compartment_70101", "id": "reaction_10503048", "reactome": "R-CEL-70467", "name": "D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_29512" ], "products": [ "species_30014", "species_29370" ], "modifiers": [ [ "species_10503045", "catalyst" ], [ "species_30533", "catalyst" ], [ "species_29370", "catalyst" ], [ "species_76577", "catalyst" ], [ "species_113592", "inhibitor" ], [ "species_76190", "inhibitor" ] ], "additional_components": [ "Q9TZL8", "WBGene00022199", "Q27483", "WBGene00008230" ] }, "reaction_10511375": { "compartment": "compartment_13231", "id": "reaction_10511375", "reactome": "R-CEL-170825", "name": "glucokinase [nucleoplasm] => glucokinase [cytosol]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10511373" ], "products": [ "species_10502937" ], "modifiers": [], "additional_components": [ "Q19440", "WBGene00008780", "Q9N4A5", "WBGene00022306", "Q9XU15", "WBGene00010416", "Q9N4A5", "WBGene00022306", "Q9XU15", "WBGene00010416", "Q19440", "WBGene00008780" ] }, "reaction_10502958": { "compartment": "compartment_70101", "id": "reaction_10502958", "reactome": "R-CEL-70420", "name": "HK1,2,3,GCK phosphorylate Glc to form G6P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_70113" ], "products": [ "species_70106", "species_29370", "species_30537" ], "modifiers": [ [ "species_10502955", "catalyst" ] ], "additional_components": [ "Q19440", "WBGene00008780", "Q9N4A5", "WBGene00022306", "Q9XU15", "WBGene00010416" ] }, "reaction_10504334": { "compartment": "compartment_70101", "id": "reaction_10504334", "reactome": "R-CEL-71850", "name": "1,3-bisphospho-D-glycerate + ADP <=> 3-phospho-D-glycerate + ATP", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29370", "species_29800" ], "products": [ "species_113592", "species_29728" ], "modifiers": [ [ "species_10503093", "catalyst" ] ], "additional_components": [ "species_114632", "P91427", "WBGene00020185" ] }, "reaction_10502997": { "compartment": "compartment_70101", "id": "reaction_10502997", "reactome": "R-CEL-70449", "name": "D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29372", "species_29578", "species_29360" ], "products": [ "species_70106", "species_29800", "species_73473" ], "modifiers": [ [ "species_10502994", "catalyst" ] ], "additional_components": [ "P04970", "WBGene00001683", "P17329", "WBGene00001684", "P17330", "WBGene00001685", "P17331", "WBGene00001686" ] }, "reaction_10562107": { "compartment": "compartment_70101", "id": "reaction_10562107", "reactome": "R-CEL-6799604", "name": "GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_449701" ], "products": [ "species_29512", "species_31633" ], "modifiers": [ [ "species_10562104", "catalyst" ] ], "additional_components": [ "Q9XVJ2", "WBGene00011399" ] }, "reaction_10504221": { "compartment": "compartment_70101", "id": "reaction_10504221", "reactome": "R-CEL-71670", "name": "phosphoenolpyruvate + ADP => pyruvate + ATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29370", "species_29492" ], "products": [ "species_113592", "species_29398" ], "modifiers": [ [ "species_10504218", "catalyst" ], [ "species_30014", "catalyst" ], [ "species_76183", "inhibitor" ], [ "species_29358", "inhibitor" ], [ "species_30389", "inhibitor" ] ], "additional_components": [ "species_114632", "species_74126", "B7WNA0", "WBGene00009126", "Q23539", "WBGene00014001" ] }, "reaction_10503007": { "compartment": "compartment_70101", "id": "reaction_10503007", "reactome": "R-CEL-70454", "name": "dihydroxyacetone phosphate <=> D-glyceraldehyde 3-phosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_75970" ], "products": [ "species_29578" ], "modifiers": [ [ "species_10503004", "catalyst" ] ], "additional_components": [ "Q10657", "WBGene00006601" ] }, "reaction_10529025": { "compartment": "compartment_5460", "id": "reaction_10529025", "reactome": "R-CEL-916855", "name": "PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_916850", "species_113594" ], "products": [ "species_880046", "species_113552" ], "modifiers": [ [ "species_10529022", "catalyst" ] ], "additional_components": [ "CHEBI:33739", "Q21217", "WBGene00001794" ] }, "reaction_10528302": { "compartment": "compartment_5460", "id": "reaction_10528302", "reactome": "R-CEL-888548", "name": "ALDH5A1 dehydrogenates SUCCSA to SUCCA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113526", "species_880046", "species_113521" ], "products": [ "species_113529", "species_29362", "species_113536" ], "modifiers": [ [ "species_10528299", "catalyst" ] ], "additional_components": [ "O02266", "WBGene00000113" ] }, "reaction_10550736": { "compartment": "compartment_7660", "id": "reaction_10550736", "reactome": "R-CEL-5225602", "name": "WDR5 binds Me2sR3-replicative histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10550011", "species_10550698" ], "products": [ "species_10550734" ], "modifiers": [], "additional_components": [ "WBGene00006474", "Q17963", "WBGene00006474" ] }, "reaction_10550706": { "compartment": "compartment_7660", "id": "reaction_10550706", "reactome": "R-CEL-5218952", "name": "PRMT5:WDR77, PRMT7 methylate arginine-3 of histone H3 (H3R2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10546551" ], "products": [ "species_77502", "species_10550698" ], "modifiers": [ [ "species_10550703", "catalyst" ] ], "additional_components": [ "WBGene00012298" ] }, "reaction_10554499": { "compartment": "compartment_7660", "id": "reaction_10554499", "reactome": "R-CEL-5661126", "name": "PRMT1,PRMT6 methylate methyl-lysine-4 of histone H4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10550424" ], "products": [ "species_77502", "species_10554497" ], "modifiers": [ [ "species_10546564", "catalyst" ] ], "additional_components": [ "WBGene00001875", "WBGene00001875", "WBGene00013766" ] }, "reaction_10550740": { "compartment": "compartment_7660", "id": "reaction_10550740", "reactome": "R-CEL-5225649", "name": "RBBP7 binds histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10517096", "species_10546551" ], "products": [ "species_10550738" ], "modifiers": [ [ "species_10550698", "inhibitor" ] ], "additional_components": [ "P90916", "WBGene00003036", "P90917", "WBGene00004312", "P90916", "WBGene00003036", "P90917", "WBGene00004312" ] }, "reaction_10550506": { "compartment": "compartment_7660", "id": "reaction_10550506", "reactome": "R-CEL-5205867", "name": "PRMT1 methylates arginine-12 of histone H2A (H2AR11)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10550491" ], "products": [ "species_77502", "species_10550504" ], "modifiers": [ [ "species_10546564", "catalyst" ] ], "additional_components": [ "WBGene00013766" ] }, "reaction_10550427": { "compartment": "compartment_7660", "id": "reaction_10550427", "reactome": "R-CEL-5205798", "name": "PRMT1,PRMT6 methylate arginine-4 of histone H4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10506929" ], "products": [ "species_77502", "species_10550424" ], "modifiers": [ [ "species_10546564", "catalyst" ] ], "additional_components": [ "WBGene00001875", "WBGene00001875", "WBGene00013766" ] }, "reaction_10554048": { "compartment": "compartment_70101", "id": "reaction_10554048", "reactome": "R-CEL-5634802", "name": "MECOM (KMT8E), PRDM16 (KMT8F) methylate lysine-10 of replicative histone H3 (H3K9)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71284", "species_10554034" ], "products": [ "species_10554038", "species_71285" ], "modifiers": [ [ "species_10554043", "catalyst" ] ], "additional_components": [ "WBGene00001207" ] }, "reaction_10554160": { "compartment": "compartment_7660", "id": "reaction_10554160", "reactome": "R-CEL-5638157", "name": "WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C), ASH1L methylate methyl-lysine-37 of histone H3 (H3K36)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10549582" ], "products": [ "species_77502", "species_10554153" ], "modifiers": [ [ "species_10549759", "catalyst" ] ], "additional_components": [ "Q23084", "WBGene00022499", "Q8I4F7", "WBGene00044070", "Q9XV44", "WBGene00009370", "Q09415", "WBGene00011068" ] }, "reaction_10549762": { "compartment": "compartment_7660", "id": "reaction_10549762", "reactome": "R-CEL-4827383", "name": "WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C) methylate lysine-37 of histone H3 (H3K36)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10546551" ], "products": [ "species_77502", "species_10549582" ], "modifiers": [ [ "species_10549759", "catalyst" ] ], "additional_components": [ "Q23084", "WBGene00022499", "Q8I4F7", "WBGene00044070", "Q9XV44", "WBGene00009370", "Q09415", "WBGene00011068" ] }, "reaction_10554178": { "compartment": "compartment_7660", "id": "reaction_10554178", "reactome": "R-CEL-5649764", "name": "DOT1L (KMT4) methylates methyl-lysine-80 of histone H3 (H3K79)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10554165" ], "products": [ "species_77502", "species_10554170" ], "modifiers": [ [ "species_10554175", "catalyst" ] ], "additional_components": [ "WBGene00021474" ] }, "reaction_10550023": { "compartment": "compartment_7660", "id": "reaction_10550023", "reactome": "R-CEL-5159245", "name": "SETD3, SETD7 (KMT7), WHSC1L1 (KMT3F), Core MLL complex methylate lysine-5 of histone H3 (H3K4)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10546551" ], "products": [ "species_77502", "species_10546549" ], "modifiers": [ [ "species_10550020", "catalyst" ] ], "additional_components": [ "Q9BL48", "WBGene00022173", "Q10661", "WBGene00001088", "G5EFZ3", "WBGene00012458", "Q09309", "WBGene00017683", "Q18221", "WBGene00004782", "G5EGI1", "WBGene00011729", "Q17963", "WBGene00006474" ] }, "reaction_10552342": { "compartment": "compartment_7660", "id": "reaction_10552342", "reactome": "R-CEL-5423038", "name": "SETD8 (KMT5A) methylates lysine-21 of histone H4 (H4K20)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10506929" ], "products": [ "species_77502", "species_10543366" ], "modifiers": [ [ "species_10543801", "catalyst" ] ], "additional_components": [ "WBGene00001875", "WBGene00001875", "WBGene00004781" ] }, "reaction_10554185": { "compartment": "compartment_7660", "id": "reaction_10554185", "reactome": "R-CEL-5649799", "name": "DOT1L (KMT4) methylates dimethyl-lysine-80 of histone H3 (H3K79)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10554170" ], "products": [ "species_77502", "species_10554183" ], "modifiers": [ [ "species_10554175", "catalyst" ] ], "additional_components": [ "WBGene00021474" ] }, "reaction_10550985": { "compartment": "compartment_7660", "id": "reaction_10550985", "reactome": "R-CEL-5244692", "name": "Core MLL complex, SMYD3, PRDM9 methylate dimethyl-lysine-5 of histone H3 (H3K4)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10549629" ], "products": [ "species_77502", "species_10550978" ], "modifiers": [ [ "species_10550982", "catalyst" ], [ "species_10550471", "inhibitor" ] ], "additional_components": [ "Q10661", "WBGene00001088", "G5EFZ3", "WBGene00012458", "Q09309", "WBGene00017683", "Q18221", "WBGene00004782", "G5EGI1", "WBGene00011729", "Q17963", "WBGene00006474", "Q09415", "WBGene00011068" ] }, "reaction_10549737": { "compartment": "compartment_7660", "id": "reaction_10549737", "reactome": "R-CEL-4827382", "name": "SUV39H1 (KMT1A), SUV39H2 (KTM1B), SETDB1 (KMT1E), SETDB2 (KMT1F) methylate dimethyl-lysine-10 of histone H3 (H3K9)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10549601" ], "products": [ "species_77502", "species_10549722" ], "modifiers": [ [ "species_10549734", "catalyst" ] ], "additional_components": [ "P34544", "WBGene00019883", "Q18221", "WBGene00004782" ] }, "reaction_10554187": { "compartment": "compartment_7660", "id": "reaction_10554187", "reactome": "R-CEL-5649801", "name": "DOT1L (KMT4) methylates lysine-80 of histone H3 (H3K79)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10546551" ], "products": [ "species_77502", "species_10554165" ], "modifiers": [ [ "species_10554175", "catalyst" ] ], "additional_components": [ "WBGene00021474" ] }, "reaction_10554110": { "compartment": "compartment_7660", "id": "reaction_10554110", "reactome": "R-CEL-5637686", "name": "WHSC1L1 (KMT3F), Core MLL complex, SMYD3 (KMT3E) methylate methyl-lysine-5 of histone H3 (H3K4)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10546549" ], "products": [ "species_77502", "species_10549629" ], "modifiers": [ [ "species_10554107", "catalyst" ] ], "additional_components": [ "Q9BL48", "WBGene00022173", "Q10661", "WBGene00001088", "G5EFZ3", "WBGene00012458", "Q09309", "WBGene00017683", "Q18221", "WBGene00004782", "G5EGI1", "WBGene00011729", "Q17963", "WBGene00006474", "Q09415", "WBGene00011068" ] }, "reaction_10549670": { "compartment": "compartment_7660", "id": "reaction_10549670", "reactome": "R-CEL-4754187", "name": "KDM6A, KDM6B, KDM7A demethylate Me2K28-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113671", "species_113685", "species_10549648" ], "products": [ "species_29478", "species_10549653", "species_159942", "species_159939" ], "modifiers": [ [ "species_10549667", "catalyst" ] ], "additional_components": [ "Q19760", "WBGene00009089", "Q95QK3", "WBGene00017571", "Q20367", "WBGene00005013", "Q9GYI0", "WBGene00017920" ] }, "reaction_10554473": { "compartment": "compartment_7660", "id": "reaction_10554473", "reactome": "R-CEL-5661114", "name": "KDM2A, KDM2B, KDM4A demethylate Me2K37-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10554153", "species_113671", "species_113685" ], "products": [ "species_10549582", "species_29478", "species_159942", "species_159939" ], "modifiers": [ [ "species_10549596", "catalyst" ] ], "additional_components": [ "Q95Q98", "WBGene00020821", "Q9U297", "WBGene00012982" ] }, "reaction_10549608": { "compartment": "compartment_7660", "id": "reaction_10549608", "reactome": "R-CEL-4724279", "name": "KDM4A, KDM4B, KDM4C, KDM4D demethylate Me2K10-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113671", "species_113685", "species_10549601" ], "products": [ "species_29478", "species_159942", "species_10549603", "species_159939" ], "modifiers": [ [ "species_10549594", "catalyst" ] ], "additional_components": [ "WBGene00012982" ] }, "reaction_10554475": { "compartment": "compartment_7660", "id": "reaction_10554475", "reactome": "R-CEL-5661115", "name": "KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate Me2K10-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113671", "species_113685", "species_10549601" ], "products": [ "species_29478", "species_159942", "species_10549603", "species_159939" ], "modifiers": [ [ "species_10549616", "catalyst" ] ], "additional_components": [ "Q9GYI0", "WBGene00017920", "Q20367", "WBGene00005013" ] }, "reaction_10549643": { "compartment": "compartment_7660", "id": "reaction_10549643", "reactome": "R-CEL-4754181", "name": "KDM5A-D demethylate Me2K5-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10549629", "species_113671", "species_113685" ], "products": [ "species_29478", "species_10546549", "species_159942", "species_159939" ], "modifiers": [ [ "species_10549634", "catalyst" ] ], "additional_components": [ "WBGene00004319" ] }, "reaction_10554477": { "compartment": "compartment_7660", "id": "reaction_10554477", "reactome": "R-CEL-5661116", "name": "KDM5A-D demethylate Me3K5-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113671", "species_113685", "species_10550978" ], "products": [ "species_10549629", "species_29478", "species_159942", "species_159939" ], "modifiers": [ [ "species_10549634", "catalyst" ] ], "additional_components": [ "WBGene00004319" ] }, "reaction_10549619": { "compartment": "compartment_7660", "id": "reaction_10549619", "reactome": "R-CEL-4724284", "name": "KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate MeK10-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113671", "species_113685", "species_10549603" ], "products": [ "species_10546551", "species_29478", "species_159942", "species_159939" ], "modifiers": [ [ "species_10549616", "catalyst" ] ], "additional_components": [ "Q9GYI0", "WBGene00017920", "Q20367", "WBGene00005013" ] }, "reaction_10554484": { "compartment": "compartment_7660", "id": "reaction_10554484", "reactome": "R-CEL-5661120", "name": "KDM4A, KDM4B, KDM4C, KDM4D, MINA demethylate Me3K10-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10549722", "species_113671", "species_113685" ], "products": [ "species_29478", "species_159942", "species_159939", "species_10549601" ], "modifiers": [ [ "species_10549594", "catalyst" ] ], "additional_components": [ "WBGene00012982" ] }, "reaction_10554486": { "compartment": "compartment_7660", "id": "reaction_10554486", "reactome": "R-CEL-5661121", "name": "KDM6A, KDM6B, KDM7A demethylate Me3K28-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10554189", "species_113671", "species_113685" ], "products": [ "species_29478", "species_159942", "species_159939", "species_10549648" ], "modifiers": [ [ "species_10549667", "catalyst" ] ], "additional_components": [ "Q19760", "WBGene00009089", "Q95QK3", "WBGene00017571", "Q20367", "WBGene00005013", "Q9GYI0", "WBGene00017920" ] }, "reaction_10552345": { "compartment": "compartment_7660", "id": "reaction_10552345", "reactome": "R-CEL-5423117", "name": "PHF8 demethylates MeK21-histone H4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113671", "species_10543366", "species_113685" ], "products": [ "species_29478", "species_159942", "species_159939", "species_10506929" ], "modifiers": [ [ "species_10543372", "catalyst" ] ], "additional_components": [ "WBGene00001875", "WBGene00001875", "WBGene00017920" ] }, "reaction_10554488": { "compartment": "compartment_7660", "id": "reaction_10554488", "reactome": "R-CEL-5661122", "name": "JMJD6 demethylates Me2R3-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113671", "species_10550469", "species_113685" ], "products": [ "species_29478", "species_10546774", "species_159942", "species_159939" ], "modifiers": [ [ "species_10549624", "catalyst" ] ], "additional_components": [ "WBGene00004205" ] }, "reaction_10554490": { "compartment": "compartment_7660", "id": "reaction_10554490", "reactome": "R-CEL-5661123", "name": "KDM1A, KDM1B demethylate Me2K5-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10549629" ], "products": [ "species_29478", "species_10546549" ], "modifiers": [ [ "species_10546556", "catalyst" ] ], "additional_components": [ "WBGene00000137" ] }, "reaction_10549627": { "compartment": "compartment_7660", "id": "reaction_10549627", "reactome": "R-CEL-4754176", "name": "JMJD6 demethylates MeR3-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113671", "species_10546774", "species_113685" ], "products": [ "species_10546551", "species_29478", "species_159942", "species_159939" ], "modifiers": [ [ "species_10549624", "catalyst" ] ], "additional_components": [ "WBGene00004205" ] }, "reaction_10554492": { "compartment": "compartment_7660", "id": "reaction_10554492", "reactome": "R-CEL-5661124", "name": "JMJD6 demethylates MeR4-HIST1H4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10550424", "species_113671", "species_113685" ], "products": [ "species_29478", "species_159942", "species_159939", "species_10506929" ], "modifiers": [ [ "species_10549624", "catalyst" ] ], "additional_components": [ "WBGene00001875", "WBGene00001875", "WBGene00004205" ] }, "reaction_10546559": { "compartment": "compartment_7660", "id": "reaction_10546559", "reactome": "R-CEL-3214912", "name": "KDM1A, KDM1B demethylate MeK5-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546549" ], "products": [ "species_10546551", "species_29478" ], "modifiers": [ [ "species_10546556", "catalyst" ] ], "additional_components": [ "WBGene00000137" ] }, "reaction_10549599": { "compartment": "compartment_7660", "id": "reaction_10549599", "reactome": "R-CEL-4722133", "name": "KDM2A, KDM2B, KDM4A demethylate MeK37-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10549582", "species_113671", "species_113685" ], "products": [ "species_10546551", "species_29478", "species_159942", "species_159939" ], "modifiers": [ [ "species_10549596", "catalyst" ] ], "additional_components": [ "Q95Q98", "WBGene00020821", "Q9U297", "WBGene00012982" ] }, "reaction_10554494": { "compartment": "compartment_7660", "id": "reaction_10554494", "reactome": "R-CEL-5661125", "name": "JMJD6 demethylates Me2sR4-HIST1H4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10550476", "species_113671", "species_113685" ], "products": [ "species_10550424", "species_29478", "species_159942", "species_159939" ], "modifiers": [ [ "species_10549624", "catalyst" ] ], "additional_components": [ "WBGene00001875", "WBGene00001875", "WBGene00004205" ] }, "reaction_10547753": { "compartment": "compartment_7660", "id": "reaction_10547753", "reactome": "R-CEL-3662318", "name": "Type B histone acetlytransferase complex acetylates histone H4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113560", "species_10506929" ], "products": [ "species_2485002", "species_10547743" ], "modifiers": [ [ "species_10547750", "catalyst" ] ], "additional_components": [ "WBGene00001875", "WBGene00001875", "Q21484", "WBGene00044069", "P90916", "WBGene00003036", "P90917", "WBGene00004312" ] }, "reaction_10547932": { "compartment": "compartment_7660", "id": "reaction_10547932", "reactome": "R-CEL-3662335", "name": "EP300 acetylates histone H2A, H2B, H3, H4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113560", "species_10547761" ], "products": [ "species_2485002", "species_10547929" ], "modifiers": [ [ "species_10532228", "catalyst" ] ], "additional_components": [ "WBGene00000366" ] }, "reaction_10547276": { "compartment": "compartment_7660", "id": "reaction_10547276", "reactome": "R-CEL-3318415", "name": "ATF2 acetylates histone H2B, H4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113560", "species_10547238" ], "products": [ "species_2485002", "species_10547273" ], "modifiers": [ [ "species_10510845", "catalyst" ] ], "additional_components": [ "P62784", "WBGene00001875", "Q27484", "WBGene00001915", "Q27876", "WBGene00001922", "Q27894", "WBGene00001878", "P04255", "WBGene00001885", "P04255", "WBGene00001885", "Q27484", "WBGene00001915", "Q27876", "WBGene00001922", "Q27894", "WBGene00001878", "P62784", "WBGene00001875", "WBGene00000223" ] }, "reaction_10548040": { "compartment": "compartment_7660", "id": "reaction_10548040", "reactome": "R-CEL-3769447", "name": "HDAC1:2-containing complex deacetylate histones", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10547965" ], "products": [ "species_10547971", "species_5566518" ], "modifiers": [ [ "species_10548037", "catalyst" ] ], "additional_components": [ "P62784", "WBGene00001875", "P90916", "WBGene00003036", "G5EBZ4", "WBGene00002637", "Q22516", "WBGene00000482", "G5ECR1", "WBGene00023409", "O61907", "WBGene00003025", "P90917", "WBGene00004312", "G5ECH0", "WBGene00001836", "Q09440", "WBGene00001835", "Q9NF71", "WBGene00013632", "O18691", "WBGene00013632", "Q18919", "WBGene00005006", "Q95Y41", "WBGene00022278", "A5JYT9", "WBGene00009508", "Q11107", "WBGene00003002" ] }, "reaction_10548187": { "compartment": "compartment_7660", "id": "reaction_10548187", "reactome": "R-CEL-3782655", "name": "HDAC10 deacetylates histone", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10547965" ], "products": [ "species_10547971", "species_5566518" ], "modifiers": [ [ "species_10548184", "catalyst" ] ], "additional_components": [ "P62784", "WBGene00001875", "WBGene00001838" ] }, "reaction_10520785": { "compartment": "compartment_17951", "id": "reaction_10520785", "reactome": "R-CEL-390284", "name": "propionyl-CoA + carnitine => propionylcarnitine + CoASH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_192314", "species_390294" ], "products": [ "species_193514", "species_390274" ], "modifiers": [ [ "species_10520782", "catalyst" ] ], "additional_components": [ "WBGene00007175" ] }, "reaction_10520754": { "compartment": "compartment_17951", "id": "reaction_10520754", "reactome": "R-CEL-389986", "name": "trans-2,3-dehydropristanoyl-CoA + H2O => 3-hydroxypristanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_141343", "species_389894" ], "products": [ "species_389982" ], "modifiers": [ [ "species_10513270", "catalyst" ] ], "additional_components": [ "Q19058", "WBGene00017123" ] }, "reaction_10520739": { "compartment": "compartment_17951", "id": "reaction_10520739", "reactome": "R-CEL-389889", "name": "ACOX2:FAD, ACOXL:FAD oxidise (2S)-pristanoyl-CoA to trans-2,3-dehydropristanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113535", "species_389893" ], "products": [ "species_113575", "species_389894" ], "modifiers": [ [ "species_10513307", "catalyst" ] ], "additional_components": [ "species_113596", "P34355", "WBGene00008167", "O62138", "WBGene00008566", "Q93839", "WBGene00010336", "O62139", "WBGene00008567", "O62140", "WBGene00008564", "O62137", "WBGene00008565" ] }, "reaction_10520787": { "compartment": "compartment_17951", "id": "reaction_10520787", "reactome": "R-CEL-390291", "name": "acetyl-CoA + carnitine => acetylcarnitine + CoASH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_353123", "species_390294" ], "products": [ "species_390287", "species_193514" ], "modifiers": [ [ "species_10520782", "catalyst" ] ], "additional_components": [ "WBGene00007175" ] }, "reaction_10520756": { "compartment": "compartment_17951", "id": "reaction_10520756", "reactome": "R-CEL-389995", "name": "3-hydroxypristanoyl-CoA + NAD+ => 3-ketoxypristanoyl-CoA + NADH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_389982", "species_192307" ], "products": [ "species_193465", "species_389996", "species_192305" ], "modifiers": [ [ "species_10513270", "catalyst" ] ], "additional_components": [ "Q19058", "WBGene00017123" ] }, "reaction_10520790": { "compartment": "compartment_17951", "id": "reaction_10520790", "reactome": "R-CEL-390304", "name": "acetyl-CoA + H2O => acetate + CoASH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_141343", "species_353123" ], "products": [ "species_193514", "species_390305" ], "modifiers": [ [ "species_10513389", "catalyst" ] ], "additional_components": [ "WBGene00015887" ] }, "reaction_10520777": { "compartment": "compartment_17951", "id": "reaction_10520777", "reactome": "R-CEL-390281", "name": "4,8-dimethylnonanoyl-CoA + carnitine => 4,8-dimethylnonanoylcarnitine + CoASH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_390271", "species_390294" ], "products": [ "species_193514", "species_390290" ], "modifiers": [ [ "species_10520774", "catalyst" ] ], "additional_components": [ "WBGene00011850" ] }, "reaction_10520749": { "compartment": "compartment_17951", "id": "reaction_10520749", "reactome": "R-CEL-389891", "name": "(2S)-pristanoyl-CoA + O2 => trans-2,3-dehydropristanoyl-CoA + H2O2 (ACOX3)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113535", "species_389893" ], "products": [ "species_113575", "species_389894" ], "modifiers": [ [ "species_10520746", "catalyst" ] ], "additional_components": [ "species_113596", "Q20992", "WBGene00019060" ] }, "reaction_10520751": { "compartment": "compartment_17951", "id": "reaction_10520751", "reactome": "R-CEL-389897", "name": "Isomerization of (2R)-pristanoyl-CoA to (2S)-pristanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_389569" ], "products": [ "species_389893" ], "modifiers": [ [ "species_10513241", "catalyst" ] ], "additional_components": [ "WBGene00016034" ] }, "reaction_10513025": { "compartment": "compartment_70101", "id": "reaction_10513025", "reactome": "R-CEL-191323", "name": "HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191293", "species_76183" ], "products": [ "species_29356", "species_191374", "species_76194" ], "modifiers": [ [ "species_10513022", "catalyst" ] ], "additional_components": [ "WBGene00017769" ] }, "reaction_10513507": { "compartment": "compartment_70101", "id": "reaction_10513507", "reactome": "R-CEL-194642", "name": "4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_194735", "species_29360" ], "products": [ "species_70106", "species_113528", "species_194667", "species_73473" ], "modifiers": [ [ "species_10513504", "catalyst" ] ], "additional_components": [ "WBGene00012394" ] }, "reaction_10513509": { "compartment": "compartment_70101", "id": "reaction_10513509", "reactome": "R-CEL-194718", "name": "4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_194657", "species_29360" ], "products": [ "species_70106", "species_113528", "species_194661", "species_73473" ], "modifiers": [ [ "species_10513504", "catalyst" ] ], "additional_components": [ "WBGene00012394" ] }, "reaction_10513665": { "compartment": "compartment_70101", "id": "reaction_10513665", "reactome": "R-CEL-196402", "name": "Cholesta-5,7,24-trien-3beta-ol is reduced to desmosterol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_195655", "species_29364" ], "products": [ "species_29366", "species_196420" ], "modifiers": [ [ "species_10513662", "catalyst" ] ], "additional_components": [ "WBGene00007126" ] }, "reaction_10513673": { "compartment": "compartment_70101", "id": "reaction_10513673", "reactome": "R-CEL-196417", "name": "Reduction of desmosterol to cholesterol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_196420", "species_29364" ], "products": [ "species_193384", "species_29366" ], "modifiers": [ [ "species_10513670", "catalyst" ] ], "additional_components": [ "WBGene00018718" ] }, "reaction_10513065": { "compartment": "compartment_70101", "id": "reaction_10513065", "reactome": "R-CEL-191414", "name": "MVD decarboxylates MVA5PP to IPPP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_191403" ], "products": [ "species_29372", "species_29370", "species_113528", "species_191362" ], "modifiers": [ [ "species_10513062", "catalyst" ] ], "additional_components": [ "Q9U294", "WBGene00012984" ] }, "reaction_10513035": { "compartment": "compartment_70101", "id": "reaction_10513035", "reactome": "R-CEL-191352", "name": "HMGCR dimer reduces bHMG-CoA to MVA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191374", "species_70106", "species_29364" ], "products": [ "species_29366", "species_76194", "species_191424" ], "modifiers": [ [ "species_10513032", "catalyst" ] ], "additional_components": [ "Q19207", "WBGene00017268" ] }, "reaction_10563129": { "compartment": "compartment_12045", "id": "reaction_10563129", "reactome": "R-CEL-6807055", "name": "DHCR7 reduces 7-dehydroCHOL to CHOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_6807057", "species_29364" ], "products": [ "species_193384", "species_29366" ], "modifiers": [ [ "species_10513662", "catalyst" ] ], "additional_components": [ "WBGene00007126" ] }, "reaction_10563131": { "compartment": "compartment_12045", "id": "reaction_10563131", "reactome": "R-CEL-6807064", "name": "DHCR24 reduces ZYMOL to ZYMSTNL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_194691" ], "products": [ "species_6807048", "species_29366" ], "modifiers": [ [ "species_10513670", "catalyst" ] ], "additional_components": [ "WBGene00018718" ] }, "reaction_10513073": { "compartment": "compartment_70101", "id": "reaction_10513073", "reactome": "R-CEL-191422", "name": "Mevalonate-5-phosphate is further phosphorylated.", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_191296" ], "products": [ "species_29370", "species_191403" ], "modifiers": [ [ "species_10513070", "catalyst" ] ], "additional_components": [ "WBGene00009335" ] }, "reaction_10513045": { "compartment": "compartment_70101", "id": "reaction_10513045", "reactome": "R-CEL-191380", "name": "Mevalonate is phosphorylated to mevalonate-5-phosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_191424" ], "products": [ "species_29370", "species_191296" ], "modifiers": [ [ "species_10513042", "catalyst" ] ], "additional_components": [ "Q65XX9", "WBGene00021534" ] }, "reaction_10569175": { "compartment": "compartment_70101", "id": "reaction_10569175", "reactome": "R-CEL-8952137", "name": "Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_191265" ], "products": [ "species_8952135", "species_29372" ], "modifiers": [ [ "species_10569172", "catalyst" ] ], "additional_components": [ "WBGene00020486" ] }, "reaction_10513017": { "compartment": "compartment_70101", "id": "reaction_10513017", "reactome": "R-CEL-191303", "name": "Another isopentenyl pyrophosphate is added to geranyl pyrophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191409", "species_191362" ], "products": [ "species_111294", "species_191385" ], "modifiers": [ [ "species_10513014", "catalyst" ] ], "additional_components": [ "O62336", "WBGene00011058", "species_114632" ] }, "reaction_10551001": { "compartment": "compartment_17957", "id": "reaction_10551001", "reactome": "R-CEL-5250531", "name": "ARV1 transports CHOL from ER membrane to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193384" ], "products": [ "species_171095" ], "modifiers": [ [ "species_10550998", "catalyst" ] ], "additional_components": [ "WBGene00011040" ] }, "reaction_10513020": { "compartment": "compartment_70101", "id": "reaction_10513020", "reactome": "R-CEL-191322", "name": "Addition of isopentenyl pyrophosphate to DMAPP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191324", "species_191362" ], "products": [ "species_111294", "species_191409" ], "modifiers": [ [ "species_10513014", "catalyst" ] ], "additional_components": [ "O62336", "WBGene00011058", "species_114632" ] }, "reaction_10513055": { "compartment": "compartment_70101", "id": "reaction_10513055", "reactome": "R-CEL-191382", "name": "Isopentenyl pyrophosphate rearranges to dimethylallyl pyrophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191362" ], "products": [ "species_191324" ], "modifiers": [ [ "species_10513052", "catalyst" ] ], "additional_components": [ "species_114632", "G5EFQ1", "WBGene00019460" ] }, "reaction_10546084": { "compartment": "compartment_7660", "id": "reaction_10546084", "reactome": "R-CEL-2993780", "name": "Transfer of SUMO1 from E1 to UBE2I (UBC9)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546073", "species_10546009" ], "products": [ "species_10546081", "species_10545999" ], "modifiers": [ [ "species_10545999", "catalyst" ] ], "additional_components": [ "WBGene00006706", "Q9NAN1", "WBGene00006700", "P55853", "WBGene00004888", "Q17820", "WBGene00000142", "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "Q17820", "WBGene00000142", "Q9NAN1", "WBGene00006700", "Q17820", "WBGene00000142", "Q9NAN1", "WBGene00006700" ] }, "reaction_10563041": { "compartment": "compartment_984", "id": "reaction_10563041", "reactome": "R-CEL-6804099", "name": "HMGB1 binds LTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10563037", "species_181015" ], "products": [ "species_10563039" ], "modifiers": [], "additional_components": [ "G5EFV4", "WBGene00001971", "Q09390", "WBGene00001972", "species_181015", "G5EFV4", "WBGene00001971", "Q09390", "WBGene00001972" ] }, "reaction_10563090": { "compartment": "compartment_984", "id": "reaction_10563090", "reactome": "R-CEL-6805981", "name": "HMGB1 release from cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10517878" ], "products": [ "species_10563037" ], "modifiers": [], "additional_components": [ "Q09390", "WBGene00001972", "G5EFV4", "WBGene00001971", "G5EFV4", "WBGene00001971", "Q09390", "WBGene00001972" ] }, "reaction_10563045": { "compartment": "compartment_984", "id": "reaction_10563045", "reactome": "R-CEL-6804100", "name": "HMGB1 binds LPS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10563037", "species_166005" ], "products": [ "species_10563043" ], "modifiers": [], "additional_components": [ "G5EFV4", "WBGene00001971", "Q09390", "WBGene00001972", "species_166005", "G5EFV4", "WBGene00001971", "Q09390", "WBGene00001972" ] }, "reaction_10566733": { "compartment": "compartment_984", "id": "reaction_10566733", "reactome": "R-CEL-8869683", "name": "oxPL binds LBP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10510717", "species_2186967" ], "products": [ "species_10566731" ], "modifiers": [], "additional_components": [ "Q20380", "WBGene00022627", "Q17654", "WBGene00022627", "H9G2Z8", "WBGene00022627", "Q23365", "WBGene00022627", "Q17738", "WBGene00022627", "O17768", "WBGene00022627", "Q93796", "WBGene00003812", "Q18869", "WBGene00022627", "Q10011", "WBGene00020563", "A8WFJ7", "WBGene00022627", "species_2186967", "Q20380", "WBGene00022627", "Q17654", "WBGene00022627", "H9G2Z8", "WBGene00022627", "Q23365", "WBGene00022627", "Q17738", "WBGene00022627", "O17768", "WBGene00022627", "Q93796", "WBGene00003812", "Q18869", "WBGene00022627", "Q10011", "WBGene00020563", "A8WFJ7", "WBGene00022627" ] }, "reaction_10510723": { "compartment": "compartment_984", "id": "reaction_10510723", "reactome": "R-CEL-166015", "name": "Association of LBP with LPS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10510717", "species_166005" ], "products": [ "species_10510719" ], "modifiers": [ [ "species_10510721", "inhibitor" ] ], "additional_components": [ "Q20380", "WBGene00022627", "Q17654", "WBGene00022627", "H9G2Z8", "WBGene00022627", "Q23365", "WBGene00022627", "Q17738", "WBGene00022627", "O17768", "WBGene00022627", "Q93796", "WBGene00003812", "Q18869", "WBGene00022627", "Q10011", "WBGene00020563", "A8WFJ7", "WBGene00022627", "species_166005", "Q20380", "WBGene00022627", "Q17654", "WBGene00022627", "H9G2Z8", "WBGene00022627", "Q23365", "WBGene00022627", "Q17738", "WBGene00022627", "O17768", "WBGene00022627", "Q93796", "WBGene00003812", "Q18869", "WBGene00022627", "Q10011", "WBGene00020563", "A8WFJ7", "WBGene00022627", "WBGene00020563" ] }, "reaction_10569028": { "compartment": "compartment_70101", "id": "reaction_10569028", "reactome": "R-CEL-8950778", "name": "p-Y693-STAT4 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10568972" ], "products": [ "species_10568974" ], "modifiers": [], "additional_components": [ "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111" ] }, "reaction_10568984": { "compartment": "compartment_70101", "id": "reaction_10568984", "reactome": "R-CEL-8950181", "name": "Y693-STAT4 dimer translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10568974" ], "products": [ "species_10568982" ], "modifiers": [], "additional_components": [ "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111" ] }, "reaction_10569026": { "compartment": "compartment_876", "id": "reaction_10569026", "reactome": "R-CEL-8950766", "name": "IL27RA dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10569022" ], "products": [ "species_10569024" ], "modifiers": [], "additional_components": [ "WBGene00002915", "Q9UB28", "WBGene00002915" ] }, "reaction_10569032": { "compartment": "compartment_70101", "id": "reaction_10569032", "reactome": "R-CEL-8950782", "name": "p-STAT1 binds p-STAT3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10531883", "species_10528453" ], "products": [ "species_10531889" ], "modifiers": [], "additional_components": [ "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111" ] }, "reaction_10569020": { "compartment": "compartment_70101", "id": "reaction_10569020", "reactome": "R-CEL-8950733", "name": "p-Y701-STAT1:p-Y705-STAT3 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10531889" ], "products": [ "species_10531901" ], "modifiers": [], "additional_components": [ "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111" ] }, "reaction_10568990": { "compartment": "compartment_17957", "id": "reaction_10568990", "reactome": "R-CEL-8950387", "name": "CANX binds EBI3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10568986", "species_10527249" ], "products": [ "species_10568988" ], "modifiers": [], "additional_components": [ "WBGene00002915", "WBGene00000567", "P34652", "WBGene00000567", "Q9UB28", "WBGene00002915" ] }, "reaction_10569012": { "compartment": "compartment_70101", "id": "reaction_10569012", "reactome": "R-CEL-8950522", "name": "p-STAT1:p-STAT4 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10569008" ], "products": [ "species_10569010" ], "modifiers": [], "additional_components": [ "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111" ] }, "reaction_10521955": { "compartment": "compartment_70101", "id": "reaction_10521955", "reactome": "R-CEL-419049", "name": "ROCK activation by RHO", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10521949", "species_10509488" ], "products": [ "species_10521951" ], "modifiers": [ [ "species_10521953", "inhibitor" ] ], "additional_components": [ "P92199", "WBGene00002694", "Q21025", "WBGene00019087", "Q9XVH4", "WBGene00019087", "Q22038", "WBGene00004357", "species_29438", "Q22038", "WBGene00004357", "species_29438", "P92199", "WBGene00002694", "Q21025", "WBGene00019087", "Q9XVH4", "WBGene00019087", "P92199", "WBGene00002694", "Q21025", "WBGene00019087", "Q9XVH4", "WBGene00019087" ] }, "reaction_10573094": { "compartment": "compartment_70101", "id": "reaction_10573094", "reactome": "R-CEL-9680443", "name": "ROCK1,2 bind ROCKi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9686558", "species_10521949" ], "products": [ "species_10521953" ], "modifiers": [], "additional_components": [ "P92199", "WBGene00002694", "Q21025", "WBGene00019087", "Q9XVH4", "WBGene00019087", "P92199", "WBGene00002694", "Q21025", "WBGene00019087", "Q9XVH4", "WBGene00019087" ] }, "reaction_10514868": { "compartment": "compartment_70101", "id": "reaction_10514868", "reactome": "R-CEL-201608", "name": "Caspase-mediated cleavage of alpha adducin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10514862" ], "products": [ "species_10514866", "species_10514864" ], "modifiers": [ [ "species_10509422", "catalyst" ] ], "additional_components": [ "WBGene00000073", "WBGene00000073", "WBGene00000073", "P42573", "WBGene00000417" ] }, "reaction_10515348": { "compartment": "compartment_70101", "id": "reaction_10515348", "reactome": "R-CEL-202966", "name": "Caspase mediated cleavage of HIP-55", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10515342" ], "products": [ "species_10515346", "species_10515344" ], "modifiers": [ [ "species_10509422", "catalyst" ] ], "additional_components": [ "WBGene00010664", "WBGene00010664", "WBGene00010664", "P42573", "WBGene00000417" ] }, "reaction_10515359": { "compartment": "compartment_70101", "id": "reaction_10515359", "reactome": "R-CEL-202967", "name": "Caspase mediated cleavage of alpha-II-Fodrin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10515353" ], "products": [ "species_10515357", "species_10515355" ], "modifiers": [ [ "species_10509422", "catalyst" ] ], "additional_components": [ "WBGene00004951", "WBGene00004951", "WBGene00004951", "P42573", "WBGene00000417" ] }, "reaction_10572369": { "compartment": "compartment_161320", "id": "reaction_10572369", "reactome": "R-CEL-9638076", "name": "HEXB cleaves the terminal GalNAc from small HA fragments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2162223", "species_1605715" ], "products": [ "species_1678743", "species_2162224" ], "modifiers": [ [ "species_10536355", "catalyst" ] ], "additional_components": [ "Q22492", "WBGene00020509" ] }, "reaction_10543041": { "compartment": "compartment_161320", "id": "reaction_10543041", "reactome": "R-CEL-2162225", "name": "HEXA cleaves the terminal GalNAc from small HA fragments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2162223", "species_1605715" ], "products": [ "species_1678743", "species_2162224" ], "modifiers": [ [ "species_10536342", "catalyst" ] ], "additional_components": [ "Q22492", "WBGene00020509" ] }, "reaction_10543043": { "compartment": "compartment_161320", "id": "reaction_10543043", "reactome": "R-CEL-2162226", "name": "GUSB tetramer hydrolyses GlcA-1,3-GlcNAc", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2162224" ], "products": [ "species_1678743", "species_1678868" ], "modifiers": [ [ "species_10537432", "catalyst" ] ], "additional_components": [ "Q95Q32", "WBGene00013693" ] }, "reaction_10543045": { "compartment": "compartment_161320", "id": "reaction_10543045", "reactome": "R-CEL-2162227", "name": "GUSB tetramer hydrolyses (HA)2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2160866" ], "products": [ "species_2162223", "species_1678868" ], "modifiers": [ [ "species_10537432", "catalyst" ] ], "additional_components": [ "species_2162224", "Q95Q32", "WBGene00013693" ] }, "reaction_10542936": { "compartment": "compartment_161320", "id": "reaction_10542936", "reactome": "R-CEL-2160874", "name": "HYAL1 hydrolyses (HA)50", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2160864" ], "products": [ "species_2160866" ], "modifiers": [ [ "species_10537452", "catalyst" ] ], "additional_components": [ "species_2162224", "species_2162224", "WBGene00011923" ] }, "reaction_10542957": { "compartment": "compartment_876", "id": "reaction_10542957", "reactome": "R-CEL-2160892", "name": "Hyaluronidase 2 (HYAL2) hydrolyses HA into 20kDa fragments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10542954" ], "products": [ "species_2160894", "species_10542954" ], "modifiers": [ [ "species_10542954", "catalyst" ] ], "additional_components": [ "species_74016", "Q23643", "WBGene00014109", "P35449", "WBGene00003736", "G5EDU2", "WBGene00003732", "Q8T5S1", "WBGene00003730", "H2L039", "WBGene00003734", "O16452", "WBGene00003731", "species_2162224", "G5ECE8", "WBGene00011923", "species_2162224", "species_74016", "Q23643", "WBGene00014109", "P35449", "WBGene00003736", "G5EDU2", "WBGene00003732", "Q8T5S1", "WBGene00003730", "H2L039", "WBGene00003734", "O16452", "WBGene00003731", "species_2162224", "G5ECE8", "WBGene00011923", "species_74016", "Q23643", "WBGene00014109", "P35449", "WBGene00003736", "G5EDU2", "WBGene00003732", "Q8T5S1", "WBGene00003730", "H2L039", "WBGene00003734", "O16452", "WBGene00003731", "species_2162224", "G5ECE8", "WBGene00011923" ] }, "reaction_10502580": { "compartment": "compartment_7660", "id": "reaction_10502580", "reactome": "R-CEL-68950", "name": "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30187", "species_30185", "species_10502151", "species_29892", "species_29604" ], "products": [ "species_10502577" ], "modifiers": [ [ "species_10502123", "catalyst" ] ], "additional_components": [ "C7IVS4", "WBGene00012936", "P34471", "WBGene00004180", "O02334", "WBGene00004181", "Q21625", "WBGene00001002", "C7IVS4", "WBGene00012936", "P34471", "WBGene00004180", "O02334", "WBGene00004181", "Q21625", "WBGene00001002", "C7IVS4", "WBGene00012936", "P34471", "WBGene00004180", "O02334", "WBGene00004181", "Q21625", "WBGene00001002" ] }, "reaction_10502154": { "compartment": "compartment_7660", "id": "reaction_10502154", "reactome": "R-CEL-68913", "name": "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502149", "species_30595" ], "products": [ "species_10502151", "species_10502145" ], "modifiers": [ [ "species_10502149", "catalyst" ] ], "additional_components": [ "O62218", "WBGene00009368", "Q19196", "WBGene00017237", "Q22798", "WBGene00020823", "Q9NAC5", "WBGene00013150", "C7IVS4", "WBGene00012936", "P34471", "WBGene00004180", "O02334", "WBGene00004181", "Q21625", "WBGene00001002", "species_110614", "species_29358", "species_29494", "species_29438", "C7IVS4", "WBGene00012936", "P34471", "WBGene00004180", "O02334", "WBGene00004181", "Q21625", "WBGene00001002", "O62218", "WBGene00009368", "Q19196", "WBGene00017237", "Q22798", "WBGene00020823", "Q9NAC5", "WBGene00013150", "O62218", "WBGene00009368", "Q19196", "WBGene00017237", "Q22798", "WBGene00020823", "Q9NAC5", "WBGene00013150", "C7IVS4", "WBGene00012936", "P34471", "WBGene00004180", "O02334", "WBGene00004181", "Q21625", "WBGene00001002" ] }, "reaction_10502343": { "compartment": "compartment_7660", "id": "reaction_10502343", "reactome": "R-CEL-68946", "name": "Phosphorylated Orc1 is ubiquitinated while still associated with chromatin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502318", "species_10502250" ], "products": [ "species_10502321" ], "modifiers": [ [ "species_10502340", "catalyst" ] ], "additional_components": [ "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "WBGene00012650", "WBGene00012650", "Q23457", "WBGene00004320", "G5ECU1", "WBGene00004807", "Q17389", "WBGene00000836" ] }, "reaction_10502281": { "compartment": "compartment_7660", "id": "reaction_10502281", "reactome": "R-CEL-68944", "name": "Orc1 is phosphorylated by cyclin A/CDK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10502240" ], "products": [ "species_113582", "species_10502252", "species_10502250" ], "modifiers": [ [ "species_10502278", "catalyst" ] ], "additional_components": [ "O16297", "WBGene00003159", "Q95XQ8", "WBGene00003156", "Q9XXI9", "WBGene00003154", "Q21902", "WBGene00003157", "P34647", "WBGene00003158", "Q9XVR7", "WBGene00003155", "Q9XX16", "WBGene00012651", "Q23249", "WBGene00013857", "Q9XX17", "WBGene00012650", "Q21037", "WBGene00003882", "P91155", "WBGene00000382", "Q86S68", "WBGene00000413", "Q9XX16", "WBGene00012651", "Q86S68", "WBGene00000413", "P91155", "WBGene00000382", "Q23249", "WBGene00013857", "O16297", "WBGene00003159", "Q95XQ8", "WBGene00003156", "Q9XXI9", "WBGene00003154", "Q21902", "WBGene00003157", "P34647", "WBGene00003158", "Q9XVR7", "WBGene00003155", "Q21037", "WBGene00003882", "WBGene00012650", "O61847", "WBGene00019362" ] }, "reaction_10502347": { "compartment": "compartment_7660", "id": "reaction_10502347", "reactome": "R-CEL-68947", "name": "Ubiquitinated Orc1 enters the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502321" ], "products": [ "species_10502345" ], "modifiers": [], "additional_components": [ "WBGene00012650", "WBGene00012650" ] }, "reaction_10502575": { "compartment": "compartment_70101", "id": "reaction_10502575", "reactome": "R-CEL-68948", "name": "Ubiquitinated Orc1 is degraded by the proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502345" ], "products": [ "species_10502375" ], "modifiers": [ [ "species_10502572", "catalyst" ] ], "additional_components": [ "WBGene00012650", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "P91477", "WBGene00003950", "Q95PZ7", "WBGene00013435", "Q18115", "WBGene00004459", "O62102", "WBGene00003948", "O17071", "WBGene00004504", "Q10920", "WBGene00016623", "P34286", "WBGene00003952", "Q9XTT9", "WBGene00004506", "Q23449", "WBGene00004468", "Q95005", "WBGene00003925", "P46502", "WBGene00004503", "O61792", "WBGene00004464", "O17586", "WBGene00003922", "O76371", "WBGene00004505", "Q20585", "WBGene00004463", "Q95008", "WBGene00003926", "Q18787", "WBGene00004501", "Q20058", "WBGene00009445", "Q9N599", "WBGene00003924", "O16368", "WBGene00004502", "O61742", "WBGene00004466", "Q09583", "WBGene00003928", "Q966I8", "WBGene00003947", "Q04908", "WBGene00004460", "Q9XUV0", "WBGene00003951", "Q27488", "WBGene00003923", "Q9GZH5", "WBGene00004458", "O44156", "WBGene00003927", "Q22253", "WBGene00004465", "O76577", "WBGene00004467", "P90868", "WBGene00003953", "Q19324", "WBGene00004461", "Q17971", "WBGene00007588", "Q23237", "WBGene00003949", "Q20938", "WBGene00004462" ] }, "reaction_10502611": { "compartment": "compartment_70101", "id": "reaction_10502611", "reactome": "R-CEL-69016", "name": "Ubiquitinated Cdc6 is degraded by the proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502609" ], "products": [ "species_10502375" ], "modifiers": [ [ "species_10502572", "catalyst" ] ], "additional_components": [ "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "P91155", "WBGene00000382", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "P91477", "WBGene00003950", "Q95PZ7", "WBGene00013435", "Q18115", "WBGene00004459", "O62102", "WBGene00003948", "O17071", "WBGene00004504", "Q10920", "WBGene00016623", "P34286", "WBGene00003952", "Q9XTT9", "WBGene00004506", "Q23449", "WBGene00004468", "Q95005", "WBGene00003925", "P46502", "WBGene00004503", "O61792", "WBGene00004464", "O17586", "WBGene00003922", "O76371", "WBGene00004505", "Q20585", "WBGene00004463", "Q95008", "WBGene00003926", "Q18787", "WBGene00004501", "Q20058", "WBGene00009445", "Q9N599", "WBGene00003924", "O16368", "WBGene00004502", "O61742", "WBGene00004466", "Q09583", "WBGene00003928", "Q966I8", "WBGene00003947", "Q04908", "WBGene00004460", "Q9XUV0", "WBGene00003951", "Q27488", "WBGene00003923", "Q9GZH5", "WBGene00004458", "O44156", "WBGene00003927", "Q22253", "WBGene00004465", "O76577", "WBGene00004467", "P90868", "WBGene00003953", "Q19324", "WBGene00004461", "Q17971", "WBGene00007588", "Q23237", "WBGene00003949", "Q20938", "WBGene00004462" ] }, "reaction_10502601": { "compartment": "compartment_7660", "id": "reaction_10502601", "reactome": "R-CEL-69005", "name": "Cdc6 protein is phosphorylated by CDK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10502084" ], "products": [ "species_113582", "species_10502587" ], "modifiers": [ [ "species_10502598", "catalyst" ] ], "additional_components": [ "WBGene00000382", "WBGene00000382", "O01501", "WBGene00000871", "O61847", "WBGene00019362" ] }, "reaction_10502605": { "compartment": "compartment_7660", "id": "reaction_10502605", "reactome": "R-CEL-69006", "name": "Phosphorylated Cdc6 is exported from the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502587" ], "products": [ "species_10502603" ], "modifiers": [], "additional_components": [ "WBGene00000382", "WBGene00000382" ] }, "reaction_10502615": { "compartment": "compartment_7660", "id": "reaction_10502615", "reactome": "R-CEL-69019", "name": "Mcm4,6,7 trimer forms and associates with the replication fork", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502216" ], "products": [ "species_10502189", "species_10502199", "species_10502214", "species_10502613" ], "modifiers": [], "additional_components": [ "O16297", "WBGene00003159", "Q95XQ8", "WBGene00003156", "Q9XXI9", "WBGene00003154", "Q21902", "WBGene00003157", "P34647", "WBGene00003158", "Q9XVR7", "WBGene00003155", "WBGene00003155", "WBGene00003157", "WBGene00003154", "O16297", "WBGene00003159", "Q95XQ8", "WBGene00003156", "P34647", "WBGene00003158" ] }, "reaction_10512052": { "compartment": "compartment_7660", "id": "reaction_10512052", "reactome": "R-CEL-176956", "name": "Formation of GINS complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10512043", "species_10512038", "species_10512033", "species_10512048" ], "products": [ "species_10512050" ], "modifiers": [], "additional_components": [ "WBGene00022043", "WBGene00009287", "WBGene00011275", "WBGene00013768", "Q9U2W9", "WBGene00013768", "Q22019", "WBGene00011275", "O62193", "WBGene00009287", "Q9BL54", "WBGene00022043" ] }, "reaction_10502657": { "compartment": "compartment_7660", "id": "reaction_10502657", "reactome": "R-CEL-69063", "name": "Loading of PCNA - Sliding Clamp Formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10502653", "species_10502644" ], "products": [ "species_113582", "species_10502655" ], "modifiers": [], "additional_components": [ "O02115", "WBGene00003955", "C7IVS4", "WBGene00012936", "P34471", "WBGene00004180", "O02334", "WBGene00004181", "Q21625", "WBGene00001002", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "C7IVS4", "WBGene00012936", "P34471", "WBGene00004180", "O02334", "WBGene00004181", "Q21625", "WBGene00001002", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "O02115", "WBGene00003955" ] }, "reaction_10502661": { "compartment": "compartment_7660", "id": "reaction_10502661", "reactome": "R-CEL-69068", "name": "RFC dissociates after sliding clamp formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502655" ], "products": [ "species_10502659", "species_10502642" ], "modifiers": [], "additional_components": [ "C7IVS4", "WBGene00012936", "P34471", "WBGene00004180", "O02334", "WBGene00004181", "Q21625", "WBGene00001002", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "O02115", "WBGene00003955", "C7IVS4", "WBGene00012936", "P34471", "WBGene00004180", "O02334", "WBGene00004181", "Q21625", "WBGene00001002", "O02115", "WBGene00003955", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409" ] }, "reaction_10502646": { "compartment": "compartment_7660", "id": "reaction_10502646", "reactome": "R-CEL-69053", "name": "RFC binding displaces Pol Alpha", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502642", "species_10502577" ], "products": [ "species_10502644" ], "modifiers": [], "additional_components": [ "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "C7IVS4", "WBGene00012936", "P34471", "WBGene00004180", "O02334", "WBGene00004181", "Q21625", "WBGene00001002", "C7IVS4", "WBGene00012936", "P34471", "WBGene00004180", "O02334", "WBGene00004181", "Q21625", "WBGene00001002", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409" ] }, "reaction_10502684": { "compartment": "compartment_7660", "id": "reaction_10502684", "reactome": "R-CEL-69074", "name": "Formation of Processive Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502680", "species_10502659" ], "products": [ "species_10502682" ], "modifiers": [], "additional_components": [ "P90829", "WBGene00008645", "Q19366", "WBGene00008722", "Q21730", "WBGene00011016", "C7IVS4", "WBGene00012936", "P34471", "WBGene00004180", "O02334", "WBGene00004181", "Q21625", "WBGene00001002", "O02115", "WBGene00003955", "C7IVS4", "WBGene00012936", "P34471", "WBGene00004180", "O02334", "WBGene00004181", "Q21625", "WBGene00001002", "O02115", "WBGene00003955", "P90829", "WBGene00008645", "Q19366", "WBGene00008722", "Q21730", "WBGene00011016" ] }, "reaction_10502727": { "compartment": "compartment_7660", "id": "reaction_10502727", "reactome": "R-CEL-69152", "name": "Removal of remaining Flap", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502717" ], "products": [ "species_10502719" ], "modifiers": [ [ "species_10502724", "catalyst" ] ], "additional_components": [ "C7IVS4", "WBGene00012936", "P34471", "WBGene00004180", "O02334", "WBGene00004181", "Q21625", "WBGene00001002", "O02115", "WBGene00003955", "P90829", "WBGene00008645", "Q19366", "WBGene00008722", "Q21730", "WBGene00011016", "C7IVS4", "WBGene00012936", "P34471", "WBGene00004180", "O02334", "WBGene00004181", "Q21625", "WBGene00001002", "O02115", "WBGene00003955", "P90829", "WBGene00008645", "Q19366", "WBGene00008722", "Q21730", "WBGene00011016", "WBGene00000794" ] }, "reaction_10502715": { "compartment": "compartment_7660", "id": "reaction_10502715", "reactome": "R-CEL-69142", "name": "Recruitment of Dna2 endonuclease", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502711", "species_10502706" ], "products": [ "species_10502713" ], "modifiers": [], "additional_components": [ "WBGene00001016", "Q95Y97", "WBGene00019767", "C7IVS4", "WBGene00012936", "P34471", "WBGene00004180", "O02334", "WBGene00004181", "Q21625", "WBGene00001002", "O02115", "WBGene00003955", "P90829", "WBGene00008645", "Q19366", "WBGene00008722", "Q21730", "WBGene00011016", "Q95Y97", "WBGene00019767", "C7IVS4", "WBGene00012936", "P34471", "WBGene00004180", "O02334", "WBGene00004181", "Q21625", "WBGene00001002", "O02115", "WBGene00003955", "P90829", "WBGene00008645", "Q19366", "WBGene00008722", "Q21730", "WBGene00011016", "Q9U3F2", "WBGene00001016" ] }, "reaction_10502689": { "compartment": "compartment_7660", "id": "reaction_10502689", "reactome": "R-CEL-69116", "name": "Formation of Okazaki fragments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502682" ], "products": [ "species_10502686" ], "modifiers": [ [ "species_10502680", "catalyst" ] ], "additional_components": [ "C7IVS4", "WBGene00012936", "P34471", "WBGene00004180", "O02334", "WBGene00004181", "Q21625", "WBGene00001002", "O02115", "WBGene00003955", "P90829", "WBGene00008645", "Q19366", "WBGene00008722", "Q21730", "WBGene00011016", "C7IVS4", "WBGene00012936", "P34471", "WBGene00004180", "O02334", "WBGene00004181", "Q21625", "WBGene00001002", "O02115", "WBGene00003955", "P90829", "WBGene00008645", "Q19366", "WBGene00008722", "Q21730", "WBGene00011016", "P90829", "WBGene00008645", "Q19366", "WBGene00008722", "Q21730", "WBGene00011016" ] }, "reaction_10502693": { "compartment": "compartment_7660", "id": "reaction_10502693", "reactome": "R-CEL-69127", "name": "Formation of the Flap Intermediate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502686" ], "products": [ "species_10502691" ], "modifiers": [], "additional_components": [ "C7IVS4", "WBGene00012936", "P34471", "WBGene00004180", "O02334", "WBGene00004181", "Q21625", "WBGene00001002", "O02115", "WBGene00003955", "P90829", "WBGene00008645", "Q19366", "WBGene00008722", "Q21730", "WBGene00011016", "C7IVS4", "WBGene00012936", "P34471", "WBGene00004180", "O02334", "WBGene00004181", "Q21625", "WBGene00001002", "O02115", "WBGene00003955", "P90829", "WBGene00008645", "Q19366", "WBGene00008722", "Q21730", "WBGene00011016" ] }, "reaction_10502735": { "compartment": "compartment_7660", "id": "reaction_10502735", "reactome": "R-CEL-69173", "name": "Joining of adjacent Okazaki fragments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_68452" ], "products": [ "species_69172" ], "modifiers": [ [ "species_10502732", "catalyst" ] ], "additional_components": [ "WBGene00002985" ] }, "reaction_10544506": { "compartment": "compartment_7660", "id": "reaction_10544506", "reactome": "R-CEL-2468039", "name": "Acetylation of SMC3 subunit of chromosomal arm associated cohesin by ESCO1 or ESCO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113560", "species_10544486" ], "products": [ "species_2485002", "species_10544494" ], "modifiers": [ [ "species_10544503", "catalyst" ] ], "additional_components": [ "H2L0H5", "WBGene00019953", "B2FDA8", "WBGene00004873", "Q19325", "WBGene00004737", "Q9XUB3", "WBGene00004333", "Q19555", "WBGene00004738", "O01789", "WBGene00001860", "G5EC05", "WBGene00001352", "H2L0H5", "WBGene00019953", "Q19325", "WBGene00004737", "Q9XUB3", "WBGene00004333", "Q19555", "WBGene00004738", "B2FDA8", "WBGene00004873", "O01789", "WBGene00001860", "G5EC05", "WBGene00001352", "Q19206", "WBGene00017269" ] }, "reaction_10544558": { "compartment": "compartment_7660", "id": "reaction_10544558", "reactome": "R-CEL-2473152", "name": "Acetylation of SMC3 subunit of centromeric chromatin associated cohesin by ESCO1 or ESCO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10544554", "species_113560" ], "products": [ "species_2485002", "species_10544556" ], "modifiers": [ [ "species_10544503", "catalyst" ] ], "additional_components": [ "H2L0H5", "WBGene00019953", "B2FDA8", "WBGene00004873", "Q19325", "WBGene00004737", "Q9XUB3", "WBGene00004333", "Q19555", "WBGene00004738", "O01789", "WBGene00001860", "G5EC05", "WBGene00001352", "H2L0H5", "WBGene00019953", "Q19325", "WBGene00004737", "Q9XUB3", "WBGene00004333", "Q19555", "WBGene00004738", "B2FDA8", "WBGene00004873", "O01789", "WBGene00001860", "G5EC05", "WBGene00001352", "Q19206", "WBGene00017269" ] }, "reaction_10511601": { "compartment": "compartment_70101", "id": "reaction_10511601", "reactome": "R-CEL-174054", "name": "Formation of Cyclin A:Cdk2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10511204", "species_10502737" ], "products": [ "species_10511599" ], "modifiers": [], "additional_components": [ "WBGene00019362", "O61847", "WBGene00019362" ] }, "reaction_10513907": { "compartment": "compartment_70101", "id": "reaction_10513907", "reactome": "R-CEL-198613", "name": "AKT phosphorylates p21Cip1 and p27Kip1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10512493", "species_113592" ], "products": [ "species_29370", "species_10513904" ], "modifiers": [ [ "species_10513848", "catalyst" ] ], "additional_components": [ "WBGene00000517", "WBGene00000517", "Q9XTG7", "WBGene00000103", "G4S4W1", "WBGene00016980", "Q17941", "WBGene00000102" ] }, "reaction_10512676": { "compartment": "compartment_7660", "id": "reaction_10512676", "reactome": "R-CEL-187948", "name": "Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10511632" ], "products": [ "species_113582", "species_10511634" ], "modifiers": [ [ "species_10502278", "catalyst" ] ], "additional_components": [ "WBGene00001510", "WBGene00001510", "O61847", "WBGene00019362" ] }, "reaction_10512678": { "compartment": "compartment_7660", "id": "reaction_10512678", "reactome": "R-CEL-187949", "name": "CAK-mediated phosphorylation of Cyclin A:Cdk2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10511613" ], "products": [ "species_113582", "species_10502278" ], "modifiers": [ [ "species_10506279", "catalyst" ] ], "additional_components": [ "O61847", "WBGene00019362", "O61847", "WBGene00019362", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408" ] }, "reaction_10511719": { "compartment": "compartment_13231", "id": "reaction_10511719", "reactome": "R-CEL-174273", "name": "Translocation of Cyclin A:Cdk2 complexes to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10511599" ], "products": [ "species_10511613" ], "modifiers": [], "additional_components": [ "O61847", "WBGene00019362", "O61847", "WBGene00019362" ] }, "reaction_10512609": { "compartment": "compartment_7660", "id": "reaction_10512609", "reactome": "R-CEL-187574", "name": "Degradation of ubiquitinated p27/p21 by the 26S proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10512520" ], "products": [ "species_10502318", "species_10502598", "species_10512514" ], "modifiers": [ [ "species_10512606", "catalyst" ] ], "additional_components": [ "G5ECU1", "WBGene00004807", "Q17389", "WBGene00000836", "Q17868", "WBGene00001051", "G5EEJ2", "WBGene00000517", "O01501", "WBGene00000871", "O61847", "WBGene00019362", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "O01501", "WBGene00000871", "O61847", "WBGene00019362", "G5ECU1", "WBGene00004807", "Q17389", "WBGene00000836", "Q17868", "WBGene00001051", "Q23237", "WBGene00003949", "P90868", "WBGene00003953", "Q9XUV0", "WBGene00003951", "Q966I8", "WBGene00003947", "O62102", "WBGene00003948", "O16368", "WBGene00004502", "Q18787", "WBGene00004501", "O76371", "WBGene00004505", "P46502", "WBGene00004503", "Q9XTT9", "WBGene00004506", "O17071", "WBGene00004504", "Q18115", "WBGene00004459", "Q20938", "WBGene00004462", "Q19324", "WBGene00004461", "Q22253", "WBGene00004465", "Q9GZH5", "WBGene00004458", "Q04908", "WBGene00004460", "O61742", "WBGene00004466", "O76577", "WBGene00004467", "Q20058", "WBGene00009445", "O44156", "WBGene00003927", "Q20585", "WBGene00004463", "Q27488", "WBGene00003923", "O61792", "WBGene00004464", "Q09583", "WBGene00003928", "Q23449", "WBGene00004468", "Q9N599", "WBGene00003924", "Q10920", "WBGene00016623", "Q95008", "WBGene00003926", "Q95PZ7", "WBGene00013435", "O17586", "WBGene00003922", "Q95005", "WBGene00003925", "P34286", "WBGene00003952", "P91477", "WBGene00003950" ] }, "reaction_10512612": { "compartment": "compartment_7660", "id": "reaction_10512612", "reactome": "R-CEL-187575", "name": "Ubiquitination of phospho-p27/p21", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502318", "species_10512516" ], "products": [ "species_10512520" ], "modifiers": [ [ "species_10512516", "catalyst" ] ], "additional_components": [ "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "G5ECU1", "WBGene00004807", "Q17389", "WBGene00000836", "Q17868", "WBGene00001051", "G5EEJ2", "WBGene00000517", "O01501", "WBGene00000871", "O61847", "WBGene00019362", "G5ECU1", "WBGene00004807", "Q17389", "WBGene00000836", "Q17868", "WBGene00001051", "G5EEJ2", "WBGene00000517", "O01501", "WBGene00000871", "O61847", "WBGene00019362", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "G5ECU1", "WBGene00004807", "Q17389", "WBGene00000836", "Q17868", "WBGene00001051", "G5EEJ2", "WBGene00000517", "O01501", "WBGene00000871", "O61847", "WBGene00019362" ] }, "reaction_10512518": { "compartment": "compartment_7660", "id": "reaction_10512518", "reactome": "R-CEL-187552", "name": "Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10512502", "species_10512514" ], "products": [ "species_10512516" ], "modifiers": [], "additional_components": [ "G5EEJ2", "WBGene00000517", "O01501", "WBGene00000871", "O61847", "WBGene00019362", "G5ECU1", "WBGene00004807", "Q17389", "WBGene00000836", "Q17868", "WBGene00001051", "G5ECU1", "WBGene00004807", "Q17389", "WBGene00000836", "Q17868", "WBGene00001051", "G5EEJ2", "WBGene00000517", "O01501", "WBGene00000871", "O61847", "WBGene00019362" ] }, "reaction_10512505": { "compartment": "compartment_7660", "id": "reaction_10512505", "reactome": "R-CEL-187520", "name": "Cyclin E/A:Cdk2-mediated phosphorylation of p27/p21", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10512497" ], "products": [ "species_113582", "species_10512502" ], "modifiers": [ [ "species_10512497", "catalyst" ] ], "additional_components": [ "O01501", "WBGene00000871", "O61847", "WBGene00019362", "G5EEJ2", "WBGene00000517", "G5EEJ2", "WBGene00000517", "O01501", "WBGene00000871", "O61847", "WBGene00019362", "O01501", "WBGene00000871", "O61847", "WBGene00019362", "G5EEJ2", "WBGene00000517" ] }, "reaction_10512668": { "compartment": "compartment_7660", "id": "reaction_10512668", "reactome": "R-CEL-187916", "name": "Cyclin A:Cdk2 mediated phosphorylation of p27/p21", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10512663" ], "products": [ "species_113582", "species_10512665" ], "modifiers": [ [ "species_10512663", "catalyst" ] ], "additional_components": [ "O61847", "WBGene00019362", "G5EEJ2", "WBGene00000517", "G5EEJ2", "WBGene00000517", "O61847", "WBGene00019362", "O61847", "WBGene00019362", "G5EEJ2", "WBGene00000517" ] }, "reaction_10512495": { "compartment": "compartment_13231", "id": "reaction_10512495", "reactome": "R-CEL-187506", "name": "Translocation of p27 to the nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10512493" ], "products": [ "species_10502767" ], "modifiers": [], "additional_components": [ "WBGene00000517", "WBGene00000517" ] }, "reaction_10511615": { "compartment": "compartment_7660", "id": "reaction_10511615", "reactome": "R-CEL-174110", "name": "Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10511611" ], "products": [ "species_113550", "species_10511613" ], "modifiers": [ [ "species_10502759", "catalyst" ] ], "additional_components": [ "O61847", "WBGene00019362", "O61847", "WBGene00019362", "WBGene00000389" ] }, "reaction_10511365": { "compartment": "compartment_876", "id": "reaction_10511365", "reactome": "R-CEL-170686", "name": "Adenylate cyclase increases the GTPase activity of Gi alpha", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10511333" ], "products": [ "species_29372", "species_10511351" ], "modifiers": [ [ "species_10511333", "catalyst" ] ], "additional_components": [ "Q7KPV0", "WBGene00001745", "V6CLB7", "WBGene00020997", "species_29438", "species_114632", "Q19523", "WBGene00000068", "O16880", "WBGene00000069", "G5EE33", "WBGene00000070", "Q966F9", "WBGene00000071", "O76584", "WBGene00001673", "Q9BIG5", "WBGene00001666", "Q21917", "WBGene00001669", "P91907", "WBGene00001677", "Q93743", "WBGene00001668", "Q20907", "WBGene00001670", "Q9BIG2", "WBGene00001676", "Q20910", "WBGene00001671", "species_114632", "Q19523", "WBGene00000068", "O16880", "WBGene00000069", "G5EE33", "WBGene00000070", "Q966F9", "WBGene00000071", "species_29420", "O76584", "WBGene00001673", "Q9BIG5", "WBGene00001666", "Q21917", "WBGene00001669", "P91907", "WBGene00001677", "Q93743", "WBGene00001668", "Q20907", "WBGene00001670", "Q9BIG2", "WBGene00001676", "Q20910", "WBGene00001671", "Q7KPV0", "WBGene00001745", "V6CLB7", "WBGene00020997", "Q7KPV0", "WBGene00001745", "V6CLB7", "WBGene00020997", "species_29438", "species_114632", "Q19523", "WBGene00000068", "O16880", "WBGene00000069", "G5EE33", "WBGene00000070", "Q966F9", "WBGene00000071", "O76584", "WBGene00001673", "Q9BIG5", "WBGene00001666", "Q21917", "WBGene00001669", "P91907", "WBGene00001677", "Q93743", "WBGene00001668", "Q20907", "WBGene00001670", "Q9BIG2", "WBGene00001676", "Q20910", "WBGene00001671" ] }, "reaction_10511353": { "compartment": "compartment_876", "id": "reaction_10511353", "reactome": "R-CEL-170674", "name": "Dissociation of the Gi alpha:G olf complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10511351" ], "products": [ "species_10511335", "species_10511349", "species_10508992" ], "modifiers": [], "additional_components": [ "species_114632", "Q19523", "WBGene00000068", "O16880", "WBGene00000069", "G5EE33", "WBGene00000070", "Q966F9", "WBGene00000071", "species_29420", "O76584", "WBGene00001673", "Q9BIG5", "WBGene00001666", "Q21917", "WBGene00001669", "P91907", "WBGene00001677", "Q93743", "WBGene00001668", "Q20907", "WBGene00001670", "Q9BIG2", "WBGene00001676", "Q20910", "WBGene00001671", "Q7KPV0", "WBGene00001745", "V6CLB7", "WBGene00020997", "Q7KPV0", "WBGene00001745", "V6CLB7", "WBGene00020997", "species_29420", "species_29420", "O76584", "WBGene00001673", "Q9BIG5", "WBGene00001666", "Q21917", "WBGene00001669", "P91907", "WBGene00001677", "Q93743", "WBGene00001668", "Q20907", "WBGene00001670", "Q9BIG2", "WBGene00001676", "Q20910", "WBGene00001671", "species_114632", "Q19523", "WBGene00000068", "O16880", "WBGene00000069", "G5EE33", "WBGene00000070", "Q966F9", "WBGene00000071" ] }, "reaction_10511340": { "compartment": "compartment_876", "id": "reaction_10511340", "reactome": "R-CEL-170666", "name": "Adenylate cyclase increases the GTPase activity of G alpha-olf", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10511333" ], "products": [ "species_29372", "species_10511337" ], "modifiers": [ [ "species_10511333", "catalyst" ] ], "additional_components": [ "Q7KPV0", "WBGene00001745", "V6CLB7", "WBGene00020997", "species_29438", "species_114632", "Q19523", "WBGene00000068", "O16880", "WBGene00000069", "G5EE33", "WBGene00000070", "Q966F9", "WBGene00000071", "O76584", "WBGene00001673", "Q9BIG5", "WBGene00001666", "Q21917", "WBGene00001669", "P91907", "WBGene00001677", "Q93743", "WBGene00001668", "Q20907", "WBGene00001670", "Q9BIG2", "WBGene00001676", "Q20910", "WBGene00001671", "species_114632", "Q19523", "WBGene00000068", "O16880", "WBGene00000069", "G5EE33", "WBGene00000070", "Q966F9", "WBGene00000071", "species_29438", "O76584", "WBGene00001673", "Q9BIG5", "WBGene00001666", "Q21917", "WBGene00001669", "P91907", "WBGene00001677", "Q93743", "WBGene00001668", "Q20907", "WBGene00001670", "Q9BIG2", "WBGene00001676", "Q20910", "WBGene00001671", "Q7KPV0", "WBGene00001745", "V6CLB7", "WBGene00020997", "species_29420", "Q7KPV0", "WBGene00001745", "V6CLB7", "WBGene00020997", "species_29438", "species_114632", "Q19523", "WBGene00000068", "O16880", "WBGene00000069", "G5EE33", "WBGene00000070", "Q966F9", "WBGene00000071", "O76584", "WBGene00001673", "Q9BIG5", "WBGene00001666", "Q21917", "WBGene00001669", "P91907", "WBGene00001677", "Q93743", "WBGene00001668", "Q20907", "WBGene00001670", "Q9BIG2", "WBGene00001676", "Q20910", "WBGene00001671" ] }, "reaction_10511342": { "compartment": "compartment_876", "id": "reaction_10511342", "reactome": "R-CEL-170671", "name": "G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10511331", "species_10511283" ], "products": [ "species_10511333" ], "modifiers": [], "additional_components": [ "species_114632", "Q19523", "WBGene00000068", "O16880", "WBGene00000069", "G5EE33", "WBGene00000070", "Q966F9", "WBGene00000071", "species_29438", "O76584", "WBGene00001673", "Q9BIG5", "WBGene00001666", "Q21917", "WBGene00001669", "P91907", "WBGene00001677", "Q93743", "WBGene00001668", "Q20907", "WBGene00001670", "Q9BIG2", "WBGene00001676", "Q20910", "WBGene00001671", "Q7KPV0", "WBGene00001745", "V6CLB7", "WBGene00020997", "species_29438", "Q7KPV0", "WBGene00001745", "V6CLB7", "WBGene00020997", "species_29438", "species_114632", "Q19523", "WBGene00000068", "O16880", "WBGene00000069", "G5EE33", "WBGene00000070", "Q966F9", "WBGene00000071", "O76584", "WBGene00001673", "Q9BIG5", "WBGene00001666", "Q21917", "WBGene00001669", "P91907", "WBGene00001677", "Q93743", "WBGene00001668", "Q20907", "WBGene00001670", "Q9BIG2", "WBGene00001676", "Q20910", "WBGene00001671" ] }, "reaction_10511360": { "compartment": "compartment_876", "id": "reaction_10511360", "reactome": "R-CEL-170677", "name": "The G alpha-olf:GDP:Adenylate cyclase complex dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10511358" ], "products": [ "species_10511335", "species_10508992" ], "modifiers": [], "additional_components": [ "species_114632", "Q19523", "WBGene00000068", "O16880", "WBGene00000069", "G5EE33", "WBGene00000070", "Q966F9", "WBGene00000071", "Q7KPV0", "WBGene00001745", "V6CLB7", "WBGene00020997", "species_29420", "Q7KPV0", "WBGene00001745", "V6CLB7", "WBGene00020997", "species_29420", "species_114632", "Q19523", "WBGene00000068", "O16880", "WBGene00000069", "G5EE33", "WBGene00000070", "Q966F9", "WBGene00000071" ] }, "reaction_10511347": { "compartment": "compartment_876", "id": "reaction_10511347", "reactome": "R-CEL-170672", "name": "Galpha-olf:GTP binds to adenylate cyclase and activates it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10511283", "species_10508992" ], "products": [ "species_10511344" ], "modifiers": [ [ "species_10508992", "catalyst" ] ], "additional_components": [ "Q7KPV0", "WBGene00001745", "V6CLB7", "WBGene00020997", "species_29438", "species_114632", "Q19523", "WBGene00000068", "O16880", "WBGene00000069", "G5EE33", "WBGene00000070", "Q966F9", "WBGene00000071", "species_114632", "Q19523", "WBGene00000068", "O16880", "WBGene00000069", "G5EE33", "WBGene00000070", "Q966F9", "WBGene00000071", "Q7KPV0", "WBGene00001745", "V6CLB7", "WBGene00020997", "species_29438", "species_114632", "Q19523", "WBGene00000068", "O16880", "WBGene00000069", "G5EE33", "WBGene00000070", "Q966F9", "WBGene00000071" ] }, "reaction_10511363": { "compartment": "compartment_876", "id": "reaction_10511363", "reactome": "R-CEL-170685", "name": "Adenylaye cyclase increases the GTPase activity of G alpha-olf", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10511344" ], "products": [ "species_10511358", "species_29372" ], "modifiers": [ [ "species_10511344", "catalyst" ] ], "additional_components": [ "species_114632", "Q19523", "WBGene00000068", "O16880", "WBGene00000069", "G5EE33", "WBGene00000070", "Q966F9", "WBGene00000071", "Q7KPV0", "WBGene00001745", "V6CLB7", "WBGene00020997", "species_29438", "species_114632", "Q19523", "WBGene00000068", "O16880", "WBGene00000069", "G5EE33", "WBGene00000070", "Q966F9", "WBGene00000071", "Q7KPV0", "WBGene00001745", "V6CLB7", "WBGene00020997", "species_29420", "species_114632", "Q19523", "WBGene00000068", "O16880", "WBGene00000069", "G5EE33", "WBGene00000070", "Q966F9", "WBGene00000071", "Q7KPV0", "WBGene00001745", "V6CLB7", "WBGene00020997", "species_29438" ] }, "reaction_10511356": { "compartment": "compartment_876", "id": "reaction_10511356", "reactome": "R-CEL-170676", "name": "Adenylate cyclase converts ATP into cyclic AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592" ], "products": [ "species_111294", "species_30389" ], "modifiers": [ [ "species_10511344", "catalyst" ] ], "additional_components": [ "species_114632", "Q19523", "WBGene00000068", "O16880", "WBGene00000069", "G5EE33", "WBGene00000070", "Q966F9", "WBGene00000071", "Q7KPV0", "WBGene00001745", "V6CLB7", "WBGene00020997", "species_29438" ] }, "reaction_10509072": { "compartment": "compartment_70101", "id": "reaction_10509072", "reactome": "R-CEL-112037", "name": "Inactivation of PLC beta", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10508939" ], "products": [ "species_10509070", "species_29372", "species_10508913" ], "modifiers": [], "additional_components": [ "G5EBH0", "WBGene00001177", "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196", "species_29438", "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196", "species_29420", "WBGene00001177" ] }, "reaction_10508942": { "compartment": "compartment_70101", "id": "reaction_10508942", "reactome": "R-CEL-111879", "name": "PIP2 hydrolysis", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_179856" ], "products": [ "species_114520", "species_112275" ], "modifiers": [ [ "species_10508939", "catalyst" ] ], "additional_components": [ "G5EBH0", "WBGene00001177", "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196", "species_29438" ] }, "reaction_10509032": { "compartment": "compartment_70101", "id": "reaction_10509032", "reactome": "R-CEL-111962", "name": "PDE4A,C,D hydrolyse cAMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_30389" ], "products": [ "species_76577" ], "modifiers": [ [ "species_10509025", "catalyst" ] ], "additional_components": [ "WBGene00020114" ] }, "reaction_10572525": { "compartment": "compartment_70101", "id": "reaction_10572525", "reactome": "R-CEL-9644869", "name": "p-S54-PDE4B hydrolyses cAMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_30389" ], "products": [ "species_76577" ], "modifiers": [ [ "species_10512059", "catalyst" ] ], "additional_components": [ "WBGene00020114" ] }, "reaction_10512062": { "compartment": "compartment_70101", "id": "reaction_10512062", "reactome": "R-CEL-177284", "name": "PKA phosphorylates PDE4B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10512056" ], "products": [ "species_10512059", "species_29370" ], "modifiers": [ [ "species_10508954", "catalyst" ] ], "additional_components": [ "WBGene00020114", "WBGene00020114", "WBGene00002189" ] }, "reaction_10510834": { "compartment": "compartment_70101", "id": "reaction_10510834", "reactome": "R-CEL-167429", "name": "The receptor:G-protein complex binds GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10510829" ], "products": [ "species_10509169" ], "modifiers": [ [ "species_10508935", "catalyst" ] ], "additional_components": [ "Q20841", "WBGene00018886", "H9G358", "WBGene00018089", "A0A0K3AXD3", "WBGene00011372", "Q23033", "WBGene00020086", "P34311", "WBGene00018089", "A0A2C9C3A4", "WBGene00018089", "Q9XVQ0", "WBGene00018089", "Q09502", "WBGene00008065", "A0A3B1DQQ4", "WBGene00006864", "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "Q20841", "WBGene00018886", "H9G358", "WBGene00018089", "A0A0K3AXD3", "WBGene00011372", "Q23033", "WBGene00020086", "P34311", "WBGene00018089", "A0A2C9C3A4", "WBGene00018089", "Q9XVQ0", "WBGene00018089", "Q09502", "WBGene00008065", "A0A3B1DQQ4", "WBGene00006864", "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196", "species_29438", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196" ] }, "reaction_10510836": { "compartment": "compartment_947587", "id": "reaction_10510836", "reactome": "R-CEL-167433", "name": "G-protein beta-gamma subunits rebind the alpha-GDP subunit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509070", "species_10509165" ], "products": [ "species_10510817" ], "modifiers": [], "additional_components": [ "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196", "species_29420", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196", "species_29420" ] }, "reaction_10510831": { "compartment": "compartment_70101", "id": "reaction_10510831", "reactome": "R-CEL-167419", "name": "The receptor:G-protein complex releases GDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10510819" ], "products": [ "species_10510829", "species_29420" ], "modifiers": [], "additional_components": [ "P17343", "WBGene00001679", "P54406", "WBGene00001681", "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196", "species_29420", "Q20841", "WBGene00018886", "H9G358", "WBGene00018089", "A0A0K3AXD3", "WBGene00011372", "Q23033", "WBGene00020086", "P34311", "WBGene00018089", "A0A2C9C3A4", "WBGene00018089", "Q9XVQ0", "WBGene00018089", "Q09502", "WBGene00008065", "A0A3B1DQQ4", "WBGene00006864", "Q20841", "WBGene00018886", "H9G358", "WBGene00018089", "A0A0K3AXD3", "WBGene00011372", "Q23033", "WBGene00020086", "P34311", "WBGene00018089", "A0A2C9C3A4", "WBGene00018089", "Q9XVQ0", "WBGene00018089", "Q09502", "WBGene00008065", "A0A3B1DQQ4", "WBGene00006864", "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196", "P17343", "WBGene00001679", "P54406", "WBGene00001681" ] }, "reaction_10510815": { "compartment": "compartment_947587", "id": "reaction_10510815", "reactome": "R-CEL-167415", "name": "G-protein alpha subunit is inactivated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29420", "species_10508937" ], "products": [ "species_29438", "species_10509070" ], "modifiers": [ [ "species_10508935", "catalyst" ] ], "additional_components": [ "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196", "species_29438", "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196", "species_29420", "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196" ] }, "reaction_10524194": { "compartment": "compartment_172574", "id": "reaction_10524194", "reactome": "R-CEL-435171", "name": "NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_445829" ], "products": [ "species_445832", "species_1470067" ], "modifiers": [ [ "species_10524191", "catalyst" ] ], "additional_components": [ "species_216785", "species_113531", "species_266099", "species_216785", "species_266099", "species_113531", "Q21433", "WBGene00004877", "Q21434", "WBGene00004876", "Q95XG8", "WBGene00004878" ] }, "reaction_10532076": { "compartment": "compartment_1222693", "id": "reaction_10532076", "reactome": "R-CEL-1222516", "name": "Intraphagosomal pH is lowered to 5 by V-ATPase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106" ], "products": [ "species_1470067" ], "modifiers": [ [ "species_10532073", "catalyst" ] ], "additional_components": [ "Q9XXU9", "WBGene00006920", "Q22494", "WBGene00020507", "Q23680", "WBGene00006918", "P34462", "WBGene00010130", "Q9XW92", "WBGene00013025", "Q19626", "WBGene00006921", "Q9N5A0", "WBGene00004959", "Q95X44", "WBGene00006917", "P91303", "WBGene00006919", "G5EDB8", "WBGene00006913", "Q20591", "WBGene00009882", "C0HLB3", "WBGene00006911", "C0HLB4", "WBGene00006912", "P30628", "WBGene00006768", "B2MZD0", "WBGene00006916", "G5EEK9", "WBGene00006914", "G5EGP4", "WBGene00006915", "Q95YD5", "WBGene00016258" ] }, "reaction_10558402": { "compartment": "compartment_21994", "id": "reaction_10558402", "reactome": "R-CEL-6789031", "name": "Membrane-bound myeloperoxidase (MPO) produces hypochlorous acid (HOCl)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1222719", "species_6788973", "species_1470067" ], "products": [ "species_1222475", "species_6789150" ], "modifiers": [ [ "species_10558399", "catalyst" ] ], "additional_components": [ "P91060", "WBGene00015841", "Q1ENI8", "WBGene00004256", "Q20616", "WBGene00009897", "Q23490", "WBGene00022743", "G5EG78", "WBGene00004257", "H2KZ53", "WBGene00017968", "CHEBI:55376" ] }, "reaction_10558405": { "compartment": "compartment_1222282", "id": "reaction_10558405", "reactome": "R-CEL-6789126", "name": "Myeloperoxidase (MPO) produces hypochlorous acid (HOCl)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1222719", "species_6788973", "species_1470067" ], "products": [ "species_1222475", "species_6789150" ], "modifiers": [ [ "species_10558397", "catalyst" ] ], "additional_components": [ "P91060", "WBGene00015841", "Q1ENI8", "WBGene00004256", "Q20616", "WBGene00009897", "Q23490", "WBGene00022743", "G5EG78", "WBGene00004257", "H2KZ53", "WBGene00017968", "CHEBI:55376" ] }, "reaction_10568119": { "compartment": "compartment_1222282", "id": "reaction_10568119", "reactome": "R-CEL-8933635", "name": "Myeloperoxidase (MPO) catalyzes oxidation of nitrite to nitrogen dioxide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1222719", "species_1470067", "species_6789221" ], "products": [ "species_8933637", "species_1222475" ], "modifiers": [ [ "species_10558397", "catalyst" ] ], "additional_components": [ "P91060", "WBGene00015841", "Q1ENI8", "WBGene00004256", "Q20616", "WBGene00009897", "Q23490", "WBGene00022743", "G5EG78", "WBGene00004257", "H2KZ53", "WBGene00017968", "CHEBI:55376" ] }, "reaction_10558407": { "compartment": "compartment_21994", "id": "reaction_10558407", "reactome": "R-CEL-6789136", "name": "Myeloperoxidase (MPO) binds to the bacterial cell surface", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10558397", "species_983438" ], "products": [ "species_10558399" ], "modifiers": [], "additional_components": [ "P91060", "WBGene00015841", "Q1ENI8", "WBGene00004256", "Q20616", "WBGene00009897", "Q23490", "WBGene00022743", "G5EG78", "WBGene00004257", "H2KZ53", "WBGene00017968", "CHEBI:55376", "P91060", "WBGene00015841", "Q1ENI8", "WBGene00004256", "Q20616", "WBGene00009897", "Q23490", "WBGene00022743", "G5EG78", "WBGene00004257", "H2KZ53", "WBGene00017968", "CHEBI:55376" ] }, "reaction_10565654": { "compartment": "compartment_984", "id": "reaction_10565654", "reactome": "R-CEL-8855490", "name": "Lactoperoxidase (LPO) produces OSCN-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351629", "species_8855492" ], "products": [ "species_109276", "species_8855489" ], "modifiers": [ [ "species_10565651", "catalyst" ] ], "additional_components": [ "G5EG78", "WBGene00004257", "H2KZ53", "WBGene00017968", "P91060", "WBGene00015841", "Q1ENI8", "WBGene00004256", "Q20616", "WBGene00009897", "Q23490", "WBGene00022743", "CHEBI:55376" ] }, "reaction_10573254": { "compartment": "compartment_7660", "id": "reaction_10573254", "reactome": "R-CEL-9699579", "name": "AKT phosphorylates FOXO3 downstream of FLT3 ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10514276" ], "products": [ "species_113582", "species_10514290" ], "modifiers": [ [ "species_10514266", "catalyst" ] ], "additional_components": [ "WBGene00000912", "WBGene00000912", "G4S4W1", "WBGene00016980", "Q17941", "WBGene00000102", "Q9XTG7", "WBGene00000103" ] }, "reaction_10571976": { "compartment": "compartment_70101", "id": "reaction_10571976", "reactome": "R-CEL-9607304", "name": "SOS1-mediated nucleotide exchange of RAS downstream of FLT3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10512175", "species_29438" ], "products": [ "species_29420", "species_10511481" ], "modifiers": [ [ "species_10554987", "catalyst" ] ], "additional_components": [ "species_29420", "P22981", "WBGene00002335", "species_29438", "P22981", "WBGene00002335", "A0A1I6CMA1", "WBGene00020678", "G5EGT9", "WBGene00003007", "P29355", "WBGene00004774", "Q9N5D3", "WBGene00004947" ] }, "reaction_10573256": { "compartment": "compartment_7660", "id": "reaction_10573256", "reactome": "R-CEL-9699581", "name": "AKT-phosphorylated FOXO3 translocates to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10514290" ], "products": [ "species_10572151" ], "modifiers": [], "additional_components": [ "WBGene00000912", "WBGene00000912" ] }, "reaction_10573245": { "compartment": "compartment_876", "id": "reaction_10573245", "reactome": "R-CEL-9698170", "name": "Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508492", "species_10506890" ], "products": [ "species_10543896" ], "modifiers": [], "additional_components": [ "G5EDP9", "WBGene00000001", "A0A1I6CMA1", "WBGene00020678", "G5EGT9", "WBGene00003007", "P29355", "WBGene00004774", "G5EDJ4", "WBGene00004928", "WBGene00000090", "Q94125", "WBGene00000090", "G5EDP9", "WBGene00000001", "A0A1I6CMA1", "WBGene00020678", "G5EGT9", "WBGene00003007", "P29355", "WBGene00004774", "G5EDJ4", "WBGene00004928" ] }, "reaction_10573264": { "compartment": "compartment_70101", "id": "reaction_10573264", "reactome": "R-CEL-9705507", "name": "PDE3B hydrolyses cAMP to AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_30389" ], "products": [ "species_76577" ], "modifiers": [ [ "species_10573261", "catalyst" ] ], "additional_components": [ "WBGene00008443" ] }, "reaction_10572293": { "compartment": "compartment_70101", "id": "reaction_10572293", "reactome": "R-CEL-9629675", "name": "PDE3A hydrolyses cAMP to AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_30389" ], "products": [ "species_76577" ], "modifiers": [ [ "species_10572290", "catalyst" ] ], "additional_components": [ "WBGene00008443" ] }, "reaction_10573321": { "compartment": "compartment_70101", "id": "reaction_10573321", "reactome": "R-CEL-9708261", "name": "PDE4A hydrolyses cAMP to AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_30389" ], "products": [ "species_76577" ], "modifiers": [ [ "species_10509025", "catalyst" ] ], "additional_components": [ "WBGene00020114" ] }, "reaction_10521818": { "compartment": "compartment_70101", "id": "reaction_10521818", "reactome": "R-CEL-418553", "name": "cAMP degradation by Phosphodiesterases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_30389" ], "products": [ "species_76577" ], "modifiers": [ [ "species_10521815", "catalyst" ] ], "additional_components": [ "Q22000", "WBGene00020114", "Q9N2V9", "WBGene00022389", "P30645", "WBGene00011146", "P91119", "WBGene00016328", "O18696", "WBGene00011433" ] }, "reaction_10571834": { "compartment": "compartment_70101", "id": "reaction_10571834", "reactome": "R-CEL-9603279", "name": "PIP3 recruits PDK1 and AKT to the membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179838", "species_10515193", "species_10520802" ], "products": [ "species_10571832" ], "modifiers": [], "additional_components": [ "WBGene00021022", "G4S4W1", "WBGene00016980", "Q17941", "WBGene00000102", "Q9XTG7", "WBGene00000103", "Q9UA62", "WBGene00021022", "Q17941", "WBGene00000102", "Q9XTG7", "WBGene00000103", "G4S4W1", "WBGene00016980", "species_179838" ] }, "reaction_10521037": { "compartment": "compartment_70101", "id": "reaction_10521037", "reactome": "R-CEL-392300", "name": "G beta:gamma activated PI3Kgamma converts PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10521034", "catalyst" ] ], "additional_components": [ "Q94125", "WBGene00000090", "P17343", "WBGene00001679", "P54406", "WBGene00001681" ] }, "reaction_10570240": { "compartment": "compartment_876", "id": "reaction_10570240", "reactome": "R-CEL-8964634", "name": "CDC42 binds GNB/GNG:PAK1:ARHGEF6 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10570223", "species_10512277" ], "products": [ "species_10570229" ], "modifiers": [], "additional_components": [ "Q21430", "WBGene00010776", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "WBGene00000390", "Q05062", "WBGene00000390", "Q21430", "WBGene00010776", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "P17343", "WBGene00001679", "P54406", "WBGene00001681" ] }, "reaction_10570227": { "compartment": "compartment_876", "id": "reaction_10570227", "reactome": "R-CEL-8964599", "name": "Active PAK1 and Active CDC42 dissociates from GNB/GNG:PAK1:ARHGEF6:CDC42 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10570225" ], "products": [ "species_10520670", "species_10509165", "species_10516119", "species_10512279" ], "modifiers": [], "additional_components": [ "Q05062", "WBGene00000390", "species_29438", "Q21430", "WBGene00010776", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "WBGene00010776", "Q05062", "WBGene00000390", "species_29438" ] }, "reaction_10570232": { "compartment": "compartment_876", "id": "reaction_10570232", "reactome": "R-CEL-8964604", "name": "CDC42 in GNB/GNG:PAK1:ARHGEF6:CDC42 is activated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10570229" ], "products": [ "species_10570225" ], "modifiers": [ [ "species_10570229", "catalyst" ] ], "additional_components": [ "Q05062", "WBGene00000390", "Q21430", "WBGene00010776", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "Q05062", "WBGene00000390", "species_29438", "Q21430", "WBGene00010776", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "Q05062", "WBGene00000390", "Q21430", "WBGene00010776", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "P17343", "WBGene00001679", "P54406", "WBGene00001681" ] }, "reaction_10570234": { "compartment": "compartment_70101", "id": "reaction_10570234", "reactome": "R-CEL-8964605", "name": "PAK1:ARHGEF6 complex binds G-protein beta-gamma complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509165", "species_10570221" ], "products": [ "species_10570223" ], "modifiers": [], "additional_components": [ "P17343", "WBGene00001679", "P54406", "WBGene00001681", "Q21430", "WBGene00010776", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "Q21430", "WBGene00010776", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "P17343", "WBGene00001679", "P54406", "WBGene00001681" ] }, "reaction_10570236": { "compartment": "compartment_876", "id": "reaction_10570236", "reactome": "R-CEL-8964614", "name": "PAK1 in GNB/GNG:PAK1:ARHGEF6:Active CDC42 is activated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10570225" ], "products": [ "species_10570225" ], "modifiers": [], "additional_components": [ "Q05062", "WBGene00000390", "species_29438", "Q21430", "WBGene00010776", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "Q05062", "WBGene00000390", "species_29438", "Q21430", "WBGene00010776", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "P17343", "WBGene00001679", "P54406", "WBGene00001681" ] }, "reaction_10570238": { "compartment": "compartment_70101", "id": "reaction_10570238", "reactome": "R-CEL-8964619", "name": "PAK1 binds ARHGEF6", "reversible": "false", "notes": "", "reactants": [ "species_10520670", "species_10516119" ], "products": [ "species_10570221" ], "modifiers": [], "additional_components": [ "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "WBGene00010776", "Q21430", "WBGene00010776", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911" ] }, "reaction_10528036": { "compartment": "compartment_876", "id": "reaction_10528036", "reactome": "R-CEL-751001", "name": "Inactive G alpha (i) reassociates with G beta:gamma", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509165", "species_10511349" ], "products": [ "species_10519835" ], "modifiers": [], "additional_components": [ "P17343", "WBGene00001679", "P54406", "WBGene00001681", "species_29420", "O76584", "WBGene00001673", "Q9BIG5", "WBGene00001666", "Q21917", "WBGene00001669", "P91907", "WBGene00001677", "Q93743", "WBGene00001668", "Q20907", "WBGene00001670", "Q9BIG2", "WBGene00001676", "Q20910", "WBGene00001671", "species_29420", "O76584", "WBGene00001673", "Q9BIG5", "WBGene00001666", "Q21917", "WBGene00001669", "P91907", "WBGene00001677", "Q93743", "WBGene00001668", "Q20907", "WBGene00001670", "Q9BIG2", "WBGene00001676", "Q20910", "WBGene00001671", "P17343", "WBGene00001679", "P54406", "WBGene00001681" ] }, "reaction_10570486": { "compartment": "compartment_876", "id": "reaction_10570486", "reactome": "R-CEL-8982019", "name": "Active G alpha (i)i1/i2/i3 binds RGS proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10570468", "species_10511329" ], "products": [ "species_10570484" ], "modifiers": [], "additional_components": [ "Q18563", "WBGene00004349", "G5ECK9", "WBGene00004351", "Q23376", "WBGene00004352", "O45523", "WBGene00004353", "Q8WQC0", "WBGene00004350", "O45524", "WBGene00004354", "P49808", "WBGene00004345", "P49809", "WBGene00001179", "A0A5S9MNH1", "WBGene00004347", "O17589", "WBGene00001145", "species_29438", "O76584", "WBGene00001673", "Q9BIG5", "WBGene00001666", "Q21917", "WBGene00001669", "P91907", "WBGene00001677", "Q93743", "WBGene00001668", "Q20907", "WBGene00001670", "Q9BIG2", "WBGene00001676", "Q20910", "WBGene00001671", "species_29438", "O76584", "WBGene00001673", "Q9BIG5", "WBGene00001666", "Q21917", "WBGene00001669", "P91907", "WBGene00001677", "Q93743", "WBGene00001668", "Q20907", "WBGene00001670", "Q9BIG2", "WBGene00001676", "Q20910", "WBGene00001671", "Q18563", "WBGene00004349", "G5ECK9", "WBGene00004351", "Q23376", "WBGene00004352", "O45523", "WBGene00004353", "Q8WQC0", "WBGene00004350", "O45524", "WBGene00004354", "P49808", "WBGene00004345", "P49809", "WBGene00001179", "A0A5S9MNH1", "WBGene00004347", "O17589", "WBGene00001145" ] }, "reaction_10570217": { "compartment": "compartment_876", "id": "reaction_10570217", "reactome": "R-CEL-8964242", "name": "G protein alpha (i)-SRC complex catalyzes SRC to p-Y416-SRC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10570204", "species_113592" ], "products": [ "species_29370", "species_10570214" ], "modifiers": [ [ "species_10570204", "catalyst" ] ], "additional_components": [ "species_29438", "O76584", "WBGene00001673", "Q9BIG5", "WBGene00001666", "Q21917", "WBGene00001669", "P91907", "WBGene00001677", "Q93743", "WBGene00001668", "Q20907", "WBGene00001670", "Q9BIG2", "WBGene00001676", "Q20910", "WBGene00001671", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "species_29438", "O76584", "WBGene00001673", "Q9BIG5", "WBGene00001666", "Q21917", "WBGene00001669", "P91907", "WBGene00001677", "Q93743", "WBGene00001668", "Q20907", "WBGene00001670", "Q9BIG2", "WBGene00001676", "Q20910", "WBGene00001671", "Q9N3S5", "WBGene00021635", "G5EE56", "WBGene00005077", "species_29438", "O76584", "WBGene00001673", "Q9BIG5", "WBGene00001666", "Q21917", "WBGene00001669", "P91907", "WBGene00001677", "Q93743", "WBGene00001668", "Q20907", "WBGene00001670", "Q9BIG2", "WBGene00001676", "Q20910", "WBGene00001671", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635" ] }, "reaction_10570489": { "compartment": "compartment_876", "id": "reaction_10570489", "reactome": "R-CEL-8982020", "name": "G alpha (i)i1/i2/i3 in G (i):RGS complex is inactivated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10570484" ], "products": [ "species_29372", "species_10570470" ], "modifiers": [ [ "species_10570484", "catalyst" ] ], "additional_components": [ "species_29438", "O76584", "WBGene00001673", "Q9BIG5", "WBGene00001666", "Q21917", "WBGene00001669", "P91907", "WBGene00001677", "Q93743", "WBGene00001668", "Q20907", "WBGene00001670", "Q9BIG2", "WBGene00001676", "Q20910", "WBGene00001671", "Q18563", "WBGene00004349", "G5ECK9", "WBGene00004351", "Q23376", "WBGene00004352", "O45523", "WBGene00004353", "Q8WQC0", "WBGene00004350", "O45524", "WBGene00004354", "P49808", "WBGene00004345", "P49809", "WBGene00001179", "A0A5S9MNH1", "WBGene00004347", "O17589", "WBGene00001145", "Q18563", "WBGene00004349", "G5ECK9", "WBGene00004351", "Q23376", "WBGene00004352", "O45523", "WBGene00004353", "Q8WQC0", "WBGene00004350", "O45524", "WBGene00004354", "P49808", "WBGene00004345", "P49809", "WBGene00001179", "A0A5S9MNH1", "WBGene00004347", "O17589", "WBGene00001145", "species_29420", "O76584", "WBGene00001673", "Q9BIG5", "WBGene00001666", "Q21917", "WBGene00001669", "P91907", "WBGene00001677", "Q93743", "WBGene00001668", "Q20907", "WBGene00001670", "Q9BIG2", "WBGene00001676", "Q20910", "WBGene00001671", "species_29438", "O76584", "WBGene00001673", "Q9BIG5", "WBGene00001666", "Q21917", "WBGene00001669", "P91907", "WBGene00001677", "Q93743", "WBGene00001668", "Q20907", "WBGene00001670", "Q9BIG2", "WBGene00001676", "Q20910", "WBGene00001671", "Q18563", "WBGene00004349", "G5ECK9", "WBGene00004351", "Q23376", "WBGene00004352", "O45523", "WBGene00004353", "Q8WQC0", "WBGene00004350", "O45524", "WBGene00004354", "P49808", "WBGene00004345", "P49809", "WBGene00001179", "A0A5S9MNH1", "WBGene00004347", "O17589", "WBGene00001145" ] }, "reaction_10570472": { "compartment": "compartment_876", "id": "reaction_10570472", "reactome": "R-CEL-8982012", "name": "G alpha (i):RGS dissociates to inactive G alpha (i)i1/i2/i3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10570470" ], "products": [ "species_10511349", "species_10570468" ], "modifiers": [], "additional_components": [ "Q18563", "WBGene00004349", "G5ECK9", "WBGene00004351", "Q23376", "WBGene00004352", "O45523", "WBGene00004353", "Q8WQC0", "WBGene00004350", "O45524", "WBGene00004354", "P49808", "WBGene00004345", "P49809", "WBGene00001179", "A0A5S9MNH1", "WBGene00004347", "O17589", "WBGene00001145", "species_29420", "O76584", "WBGene00001673", "Q9BIG5", "WBGene00001666", "Q21917", "WBGene00001669", "P91907", "WBGene00001677", "Q93743", "WBGene00001668", "Q20907", "WBGene00001670", "Q9BIG2", "WBGene00001676", "Q20910", "WBGene00001671", "species_29420", "O76584", "WBGene00001673", "Q9BIG5", "WBGene00001666", "Q21917", "WBGene00001669", "P91907", "WBGene00001677", "Q93743", "WBGene00001668", "Q20907", "WBGene00001670", "Q9BIG2", "WBGene00001676", "Q20910", "WBGene00001671", "Q18563", "WBGene00004349", "G5ECK9", "WBGene00004351", "Q23376", "WBGene00004352", "O45523", "WBGene00004353", "Q8WQC0", "WBGene00004350", "O45524", "WBGene00004354", "P49808", "WBGene00004345", "P49809", "WBGene00001179", "A0A5S9MNH1", "WBGene00004347", "O17589", "WBGene00001145" ] }, "reaction_10570219": { "compartment": "compartment_70101", "id": "reaction_10570219", "reactome": "R-CEL-8964329", "name": "G protein alpha (i)-SRC complex dissociates to G protein alpha (i) and Active SRC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10570214" ], "products": [ "species_10570212", "species_10511329" ], "modifiers": [], "additional_components": [ "species_29438", "O76584", "WBGene00001673", "Q9BIG5", "WBGene00001666", "Q21917", "WBGene00001669", "P91907", "WBGene00001677", "Q93743", "WBGene00001668", "Q20907", "WBGene00001670", "Q9BIG2", "WBGene00001676", "Q20910", "WBGene00001671", "Q9N3S5", "WBGene00021635", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "G5EE56", "WBGene00005077", "species_29438", "O76584", "WBGene00001673", "Q9BIG5", "WBGene00001666", "Q21917", "WBGene00001669", "P91907", "WBGene00001677", "Q93743", "WBGene00001668", "Q20907", "WBGene00001670", "Q9BIG2", "WBGene00001676", "Q20910", "WBGene00001671" ] }, "reaction_10519851": { "compartment": "compartment_947587", "id": "reaction_10519851", "reactome": "R-CEL-380073", "name": "Liganded Gi-activating GPCR acts as a GEF for Gi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10519837" ], "products": [ "species_29420", "species_10519841" ], "modifiers": [ [ "species_10519837", "catalyst" ], [ "species_10519847", "inhibitor" ] ], "additional_components": [ "species_390899", "Q9U7D5", "WBGene00001519", "species_266074", "species_266013", "CHEBI:15650", "H2KZ99", "WBGene00016570", "O02213", "WBGene00004777", "Q19084", "WBGene00017157", "species_209794", "species_209789", "Q23033", "WBGene00020086", "A0A0K3AXD3", "WBGene00011372", "Q9XVQ0", "WBGene00018089", "A0A2C9C3A4", "WBGene00018089", "A0A3B1DQQ4", "WBGene00006864", "H9G358", "WBGene00018089", "P34311", "WBGene00018089", "Q09502", "WBGene00008065", "Q20841", "WBGene00018886", "species_879629", "G5ECB2", "WBGene00022675", "H2L0Q3", "WBGene00021528", "species_352003", "A1IMB8", "WBGene00021152", "Q09630", "WBGene00003232", "species_113552", "species_372533", "Q7JP61", "WBGene00006411", "E7EM37", "WBGene00001053", "G5EGH0", "WBGene00004779", "species_380585", "species_351601", "Q6RYS9", "WBGene00020506", "species_83909", "Q10042", "WBGene00019287", "Q19295", "WBGene00019287", "Q19779", "WBGene00017779", "Q1ZXT2", "WBGene00011878", "species_29420", "O76584", "WBGene00001673", "Q9BIG5", "WBGene00001666", "Q21917", "WBGene00001669", "P91907", "WBGene00001677", "Q93743", "WBGene00001668", "Q20907", "WBGene00001670", "Q9BIG2", "WBGene00001676", "Q20910", "WBGene00001671", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "species_390899", "Q9U7D5", "WBGene00001519", "species_266074", "species_266013", "CHEBI:15650", "H2KZ99", "WBGene00016570", "O02213", "WBGene00004777", "Q19084", "WBGene00017157", "species_209794", "species_209789", "Q23033", "WBGene00020086", "A0A0K3AXD3", "WBGene00011372", "Q9XVQ0", "WBGene00018089", "A0A2C9C3A4", "WBGene00018089", "A0A3B1DQQ4", "WBGene00006864", "H9G358", "WBGene00018089", "P34311", "WBGene00018089", "Q09502", "WBGene00008065", "Q20841", "WBGene00018886", "species_879629", "G5ECB2", "WBGene00022675", "H2L0Q3", "WBGene00021528", "species_352003", "A1IMB8", "WBGene00021152", "Q09630", "WBGene00003232", "species_113552", "species_372533", "Q7JP61", "WBGene00006411", "E7EM37", "WBGene00001053", "G5EGH0", "WBGene00004779", "species_380585", "species_351601", "Q6RYS9", "WBGene00020506", "species_83909", "Q10042", "WBGene00019287", "Q19295", "WBGene00019287", "Q19779", "WBGene00017779", "Q1ZXT2", "WBGene00011878", "species_29438", "O76584", "WBGene00001673", "Q9BIG5", "WBGene00001666", "Q21917", "WBGene00001669", "P91907", "WBGene00001677", "Q93743", "WBGene00001668", "Q20907", "WBGene00001670", "Q9BIG2", "WBGene00001676", "Q20910", "WBGene00001671", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "species_390899", "Q9U7D5", "WBGene00001519", "species_266074", "species_266013", "CHEBI:15650", "H2KZ99", "WBGene00016570", "O02213", "WBGene00004777", "Q19084", "WBGene00017157", "species_209794", "species_209789", "Q23033", "WBGene00020086", "A0A0K3AXD3", "WBGene00011372", "Q9XVQ0", "WBGene00018089", "A0A2C9C3A4", "WBGene00018089", "A0A3B1DQQ4", "WBGene00006864", "H9G358", "WBGene00018089", "P34311", "WBGene00018089", "Q09502", "WBGene00008065", "Q20841", "WBGene00018886", "species_879629", "G5ECB2", "WBGene00022675", "H2L0Q3", "WBGene00021528", "species_352003", "A1IMB8", "WBGene00021152", "Q09630", "WBGene00003232", "species_113552", "species_372533", "Q7JP61", "WBGene00006411", "E7EM37", "WBGene00001053", "G5EGH0", "WBGene00004779", "species_380585", "species_351601", "Q6RYS9", "WBGene00020506", "species_83909", "Q10042", "WBGene00019287", "Q19295", "WBGene00019287", "Q19779", "WBGene00017779", "Q1ZXT2", "WBGene00011878", "species_29420", "O76584", "WBGene00001673", "Q9BIG5", "WBGene00001666", "Q21917", "WBGene00001669", "P91907", "WBGene00001677", "Q93743", "WBGene00001668", "Q20907", "WBGene00001670", "Q9BIG2", "WBGene00001676", "Q20910", "WBGene00001671", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "WBGene00000092" ] }, "reaction_10528028": { "compartment": "compartment_984", "id": "reaction_10528028", "reactome": "R-CEL-749454", "name": "The Ligand:GPCR:Gi complex dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10519841" ], "products": [ "species_10509165", "species_10519833", "species_10511329" ], "modifiers": [], "additional_components": [ "species_390899", "Q9U7D5", "WBGene00001519", "species_266074", "species_266013", "CHEBI:15650", "H2KZ99", "WBGene00016570", "O02213", "WBGene00004777", "Q19084", "WBGene00017157", "species_209794", "species_209789", "Q23033", "WBGene00020086", "A0A0K3AXD3", "WBGene00011372", "Q9XVQ0", "WBGene00018089", "A0A2C9C3A4", "WBGene00018089", "A0A3B1DQQ4", "WBGene00006864", "H9G358", "WBGene00018089", "P34311", "WBGene00018089", "Q09502", "WBGene00008065", "Q20841", "WBGene00018886", "species_879629", "G5ECB2", "WBGene00022675", "H2L0Q3", "WBGene00021528", "species_352003", "A1IMB8", "WBGene00021152", "Q09630", "WBGene00003232", "species_113552", "species_372533", "Q7JP61", "WBGene00006411", "E7EM37", "WBGene00001053", "G5EGH0", "WBGene00004779", "species_380585", "species_351601", "Q6RYS9", "WBGene00020506", "species_83909", "Q10042", "WBGene00019287", "Q19295", "WBGene00019287", "Q19779", "WBGene00017779", "Q1ZXT2", "WBGene00011878", "species_29438", "O76584", "WBGene00001673", "Q9BIG5", "WBGene00001666", "Q21917", "WBGene00001669", "P91907", "WBGene00001677", "Q93743", "WBGene00001668", "Q20907", "WBGene00001670", "Q9BIG2", "WBGene00001676", "Q20910", "WBGene00001671", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "species_390899", "Q9U7D5", "WBGene00001519", "species_266074", "species_266013", "CHEBI:15650", "H2KZ99", "WBGene00016570", "O02213", "WBGene00004777", "Q19084", "WBGene00017157", "species_209794", "species_209789", "Q23033", "WBGene00020086", "A0A0K3AXD3", "WBGene00011372", "Q9XVQ0", "WBGene00018089", "A0A2C9C3A4", "WBGene00018089", "A0A3B1DQQ4", "WBGene00006864", "H9G358", "WBGene00018089", "P34311", "WBGene00018089", "Q09502", "WBGene00008065", "Q20841", "WBGene00018886", "species_879629", "G5ECB2", "WBGene00022675", "H2L0Q3", "WBGene00021528", "species_352003", "A1IMB8", "WBGene00021152", "Q09630", "WBGene00003232", "species_113552", "species_372533", "Q7JP61", "WBGene00006411", "E7EM37", "WBGene00001053", "G5EGH0", "WBGene00004779", "species_380585", "species_351601", "Q6RYS9", "WBGene00020506", "species_83909", "Q10042", "WBGene00019287", "Q19295", "WBGene00019287", "Q19779", "WBGene00017779", "Q1ZXT2", "WBGene00011878", "species_29438", "O76584", "WBGene00001673", "Q9BIG5", "WBGene00001666", "Q21917", "WBGene00001669", "P91907", "WBGene00001677", "Q93743", "WBGene00001668", "Q20907", "WBGene00001670", "Q9BIG2", "WBGene00001676", "Q20910", "WBGene00001671" ] }, "reaction_10528030": { "compartment": "compartment_876", "id": "reaction_10528030", "reactome": "R-CEL-749456", "name": "Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10519835", "species_10519833" ], "products": [ "species_10519837" ], "modifiers": [], "additional_components": [ "species_29420", "O76584", "WBGene00001673", "Q9BIG5", "WBGene00001666", "Q21917", "WBGene00001669", "P91907", "WBGene00001677", "Q93743", "WBGene00001668", "Q20907", "WBGene00001670", "Q9BIG2", "WBGene00001676", "Q20910", "WBGene00001671", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "species_390899", "Q9U7D5", "WBGene00001519", "species_266074", "species_266013", "CHEBI:15650", "H2KZ99", "WBGene00016570", "O02213", "WBGene00004777", "Q19084", "WBGene00017157", "species_209794", "species_209789", "Q23033", "WBGene00020086", "A0A0K3AXD3", "WBGene00011372", "Q9XVQ0", "WBGene00018089", "A0A2C9C3A4", "WBGene00018089", "A0A3B1DQQ4", "WBGene00006864", "H9G358", "WBGene00018089", "P34311", "WBGene00018089", "Q09502", "WBGene00008065", "Q20841", "WBGene00018886", "species_879629", "G5ECB2", "WBGene00022675", "H2L0Q3", "WBGene00021528", "species_352003", "A1IMB8", "WBGene00021152", "Q09630", "WBGene00003232", "species_113552", "species_372533", "Q7JP61", "WBGene00006411", "E7EM37", "WBGene00001053", "G5EGH0", "WBGene00004779", "species_380585", "species_351601", "Q6RYS9", "WBGene00020506", "species_83909", "Q10042", "WBGene00019287", "Q19295", "WBGene00019287", "Q19779", "WBGene00017779", "Q1ZXT2", "WBGene00011878", "species_390899", "Q9U7D5", "WBGene00001519", "species_266074", "species_266013", "CHEBI:15650", "H2KZ99", "WBGene00016570", "O02213", "WBGene00004777", "Q19084", "WBGene00017157", "species_209794", "species_209789", "Q23033", "WBGene00020086", "A0A0K3AXD3", "WBGene00011372", "Q9XVQ0", "WBGene00018089", "A0A2C9C3A4", "WBGene00018089", "A0A3B1DQQ4", "WBGene00006864", "H9G358", "WBGene00018089", "P34311", "WBGene00018089", "Q09502", "WBGene00008065", "Q20841", "WBGene00018886", "species_879629", "G5ECB2", "WBGene00022675", "H2L0Q3", "WBGene00021528", "species_352003", "A1IMB8", "WBGene00021152", "Q09630", "WBGene00003232", "species_113552", "species_372533", "Q7JP61", "WBGene00006411", "E7EM37", "WBGene00001053", "G5EGH0", "WBGene00004779", "species_380585", "species_351601", "Q6RYS9", "WBGene00020506", "species_83909", "Q10042", "WBGene00019287", "Q19295", "WBGene00019287", "Q19779", "WBGene00017779", "Q1ZXT2", "WBGene00011878", "species_29420", "O76584", "WBGene00001673", "Q9BIG5", "WBGene00001666", "Q21917", "WBGene00001669", "P91907", "WBGene00001677", "Q93743", "WBGene00001668", "Q20907", "WBGene00001670", "Q9BIG2", "WBGene00001676", "Q20910", "WBGene00001671", "P17343", "WBGene00001679", "P54406", "WBGene00001681" ] }, "reaction_10570497": { "compartment": "compartment_876", "id": "reaction_10570497", "reactome": "R-CEL-8982025", "name": "G alpha (q) in G (q):RGS complex is inactivated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10570476" ], "products": [ "species_10570494", "species_29372" ], "modifiers": [ [ "species_10570476", "catalyst" ] ], "additional_components": [ "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196", "species_29438", "Q18563", "WBGene00004349", "G5ECK9", "WBGene00004351", "Q23376", "WBGene00004352", "O45523", "WBGene00004353", "Q8WQC0", "WBGene00004350", "O45524", "WBGene00004354", "P49808", "WBGene00004345", "A0A5S9MNH1", "WBGene00004347", "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196", "Q18563", "WBGene00004349", "G5ECK9", "WBGene00004351", "Q23376", "WBGene00004352", "O45523", "WBGene00004353", "Q8WQC0", "WBGene00004350", "O45524", "WBGene00004354", "P49808", "WBGene00004345", "A0A5S9MNH1", "WBGene00004347", "species_29420", "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196", "species_29438", "Q18563", "WBGene00004349", "G5ECK9", "WBGene00004351", "Q23376", "WBGene00004352", "O45523", "WBGene00004353", "Q8WQC0", "WBGene00004350", "O45524", "WBGene00004354", "P49808", "WBGene00004345", "A0A5S9MNH1", "WBGene00004347" ] }, "reaction_10519681": { "compartment": "compartment_70101", "id": "reaction_10519681", "reactome": "R-CEL-379048", "name": "Liganded Gq/11-activating GPCRs act as GEFs for Gq/11", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10519672" ], "products": [ "species_29420", "species_10519674" ], "modifiers": [ [ "species_10519678", "catalyst" ] ], "additional_components": [ "species_266056", "Q20325", "WBGene00018344", "Q9XUK8", "WBGene00012275", "P91096", "WBGene00016037", "species_380585", "species_266074", "species_266013", "CHEBI:15650", "H2KZ99", "WBGene00016570", "species_70106", "species_417891", "G5EG10", "WBGene00003233", "species_113552", "species_372533", "Q9U7D5", "WBGene00001519", "CHEBI:28716", "species_390435", "CHEBI:28875", "CHEBI:53460", "CHEBI:27997", "CHEBI:16196", "species_2066763", "CHEBI:53487", "CHEBI:53486", "species_8934421", "CHEBI:53488", "CHEBI:28661", "CHEBI:28364", "CHEBI:27432", "O17899", "WBGene00010329", "species_158602", "species_419777", "P90745", "WBGene00007006", "species_209794", "species_209789", "G5EBX8", "WBGene00008890", "species_29420", "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "species_266056", "Q20325", "WBGene00018344", "Q9XUK8", "WBGene00012275", "P91096", "WBGene00016037", "species_380585", "species_266074", "species_266013", "CHEBI:15650", "H2KZ99", "WBGene00016570", "species_70106", "species_417891", "G5EG10", "WBGene00003233", "species_113552", "species_372533", "Q9U7D5", "WBGene00001519", "CHEBI:28716", "species_390435", "CHEBI:28875", "CHEBI:53460", "CHEBI:27997", "CHEBI:16196", "species_2066763", "CHEBI:53487", "CHEBI:53486", "species_8934421", "CHEBI:53488", "CHEBI:28661", "CHEBI:28364", "CHEBI:27432", "O17899", "WBGene00010329", "species_158602", "species_419777", "P90745", "WBGene00007006", "species_209794", "species_209789", "G5EBX8", "WBGene00008890", "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196", "species_29438", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "species_266013", "Q20325", "WBGene00018344", "Q9XUK8", "WBGene00012275" ] }, "reaction_10528034": { "compartment": "compartment_876", "id": "reaction_10528034", "reactome": "R-CEL-750993", "name": "Inactive G alpha (q) reassociates with G beta:gamma", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509165", "species_10509557" ], "products": [ "species_10509559" ], "modifiers": [], "additional_components": [ "P17343", "WBGene00001679", "P54406", "WBGene00001681", "species_29420", "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196", "species_29420", "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196", "P17343", "WBGene00001679", "P54406", "WBGene00001681" ] }, "reaction_10570499": { "compartment": "compartment_876", "id": "reaction_10570499", "reactome": "R-CEL-8982026", "name": "G alpha (q):RGS dissociates to inactive G alpha (q)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10570494" ], "products": [ "species_10570474", "species_10509557" ], "modifiers": [], "additional_components": [ "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196", "Q18563", "WBGene00004349", "G5ECK9", "WBGene00004351", "Q23376", "WBGene00004352", "O45523", "WBGene00004353", "Q8WQC0", "WBGene00004350", "O45524", "WBGene00004354", "P49808", "WBGene00004345", "A0A5S9MNH1", "WBGene00004347", "species_29420", "Q18563", "WBGene00004349", "G5ECK9", "WBGene00004351", "Q23376", "WBGene00004352", "O45523", "WBGene00004353", "Q8WQC0", "WBGene00004350", "O45524", "WBGene00004354", "P49808", "WBGene00004345", "A0A5S9MNH1", "WBGene00004347", "species_29420", "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196" ] }, "reaction_10521540": { "compartment": "compartment_70101", "id": "reaction_10521540", "reactome": "R-CEL-400586", "name": "G alpha (q) binds to Trio family RhoGEFs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508937", "species_10521536" ], "products": [ "species_10521538" ], "modifiers": [], "additional_components": [ "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196", "species_29438", "WBGene00006805", "O61528", "WBGene00006805", "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196", "species_29438" ] }, "reaction_10527910": { "compartment": "compartment_876", "id": "reaction_10527910", "reactome": "R-CEL-749448", "name": "Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509559", "species_10519670" ], "products": [ "species_10519672" ], "modifiers": [], "additional_components": [ "species_29420", "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "species_266056", "Q20325", "WBGene00018344", "Q9XUK8", "WBGene00012275", "P91096", "WBGene00016037", "species_380585", "species_266074", "species_266013", "CHEBI:15650", "H2KZ99", "WBGene00016570", "species_70106", "species_417891", "G5EG10", "WBGene00003233", "species_113552", "species_372533", "Q9U7D5", "WBGene00001519", "CHEBI:28716", "species_390435", "CHEBI:28875", "CHEBI:53460", "CHEBI:27997", "CHEBI:16196", "species_2066763", "CHEBI:53487", "CHEBI:53486", "species_8934421", "CHEBI:53488", "CHEBI:28661", "CHEBI:28364", "CHEBI:27432", "O17899", "WBGene00010329", "species_158602", "species_419777", "P90745", "WBGene00007006", "species_209794", "species_209789", "G5EBX8", "WBGene00008890", "species_266056", "Q20325", "WBGene00018344", "Q9XUK8", "WBGene00012275", "P91096", "WBGene00016037", "species_380585", "species_266074", "species_266013", "CHEBI:15650", "H2KZ99", "WBGene00016570", "species_70106", "species_417891", "G5EG10", "WBGene00003233", "species_113552", "species_372533", "Q9U7D5", "WBGene00001519", "CHEBI:28716", "species_390435", "CHEBI:28875", "CHEBI:53460", "CHEBI:27997", "CHEBI:16196", "species_2066763", "CHEBI:53487", "CHEBI:53486", "species_8934421", "CHEBI:53488", "CHEBI:28661", "CHEBI:28364", "CHEBI:27432", "O17899", "WBGene00010329", "species_158602", "species_419777", "P90745", "WBGene00007006", "species_209794", "species_209789", "G5EBX8", "WBGene00008890", "species_29420", "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196", "P17343", "WBGene00001679", "P54406", "WBGene00001681" ] }, "reaction_10543427": { "compartment": "compartment_70101", "id": "reaction_10543427", "reactome": "R-CEL-2179407", "name": "SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10512175", "species_29438" ], "products": [ "species_29420", "species_10511481" ], "modifiers": [ [ "species_10543424", "catalyst" ] ], "additional_components": [ "species_29420", "P22981", "WBGene00002335", "species_29438", "P22981", "WBGene00002335", "P29355", "WBGene00004774", "Q9N5D3", "WBGene00004947", "P24348", "WBGene00002299" ] }, "reaction_10543444": { "compartment": "compartment_876", "id": "reaction_10543444", "reactome": "R-CEL-2179413", "name": "Activated PKC-alpha activate MMP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10543441" ], "products": [ "species_10534164" ], "modifiers": [ [ "species_10521475", "catalyst" ] ], "additional_components": [ "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "Q21182", "WBGene00194737", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "P90980", "WBGene00004033", "species_114519" ] }, "reaction_10521477": { "compartment": "compartment_876", "id": "reaction_10521477", "reactome": "R-CEL-400015", "name": "Diacylgycerol activates Protein kinase C, alpha type", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_114519", "species_10509044" ], "products": [ "species_10521475" ], "modifiers": [], "additional_components": [ "WBGene00004033", "P90980", "WBGene00004033", "species_114519" ] }, "reaction_10570478": { "compartment": "compartment_876", "id": "reaction_10570478", "reactome": "R-CEL-8982017", "name": "Active G alpha (q) binds RGS proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10570474", "species_10508937" ], "products": [ "species_10570476" ], "modifiers": [], "additional_components": [ "Q18563", "WBGene00004349", "G5ECK9", "WBGene00004351", "Q23376", "WBGene00004352", "O45523", "WBGene00004353", "Q8WQC0", "WBGene00004350", "O45524", "WBGene00004354", "P49808", "WBGene00004345", "A0A5S9MNH1", "WBGene00004347", "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196", "species_29438", "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196", "species_29438", "Q18563", "WBGene00004349", "G5ECK9", "WBGene00004351", "Q23376", "WBGene00004352", "O45523", "WBGene00004353", "Q8WQC0", "WBGene00004350", "O45524", "WBGene00004354", "P49808", "WBGene00004345", "A0A5S9MNH1", "WBGene00004347" ] }, "reaction_10528019": { "compartment": "compartment_984", "id": "reaction_10528019", "reactome": "R-CEL-749452", "name": "The Ligand:GPCR:Gq complex dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10519674" ], "products": [ "species_10509165", "species_10527995", "species_10508937", "species_10528017" ], "modifiers": [], "additional_components": [ "species_266056", "Q20325", "WBGene00018344", "Q9XUK8", "WBGene00012275", "P91096", "WBGene00016037", "species_380585", "species_266074", "species_266013", "CHEBI:15650", "H2KZ99", "WBGene00016570", "species_70106", "species_417891", "G5EG10", "WBGene00003233", "species_113552", "species_372533", "Q9U7D5", "WBGene00001519", "CHEBI:28716", "species_390435", "CHEBI:28875", "CHEBI:53460", "CHEBI:27997", "CHEBI:16196", "species_2066763", "CHEBI:53487", "CHEBI:53486", "species_8934421", "CHEBI:53488", "CHEBI:28661", "CHEBI:28364", "CHEBI:27432", "O17899", "WBGene00010329", "species_158602", "species_419777", "P90745", "WBGene00007006", "species_209794", "species_209789", "G5EBX8", "WBGene00008890", "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196", "species_29438", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "Q20325", "WBGene00018344", "Q9XUK8", "WBGene00012275", "P91096", "WBGene00016037", "Q18701", "WBGene00016747", "O17239", "WBGene00019616", "Q18130", "WBGene00016044", "G5EG10", "WBGene00003233", "A0A3B1DQQ4", "WBGene00006864", "H9G358", "WBGene00018089", "P34311", "WBGene00018089", "Q09502", "WBGene00008065", "Q20841", "WBGene00018886", "Q23033", "WBGene00020086", "A0A0K3AXD3", "WBGene00011372", "Q9XVQ0", "WBGene00018089", "A0A2C9C3A4", "WBGene00018089", "G5EDI0", "WBGene00007395", "O62403", "WBGene00013782", "Q9U7D5", "WBGene00001519", "Q03566", "WBGene00006576", "Q95YD7", "WBGene00016265", "H2KZ99", "WBGene00016570", "O17899", "WBGene00010329", "G5EBX8", "WBGene00008890", "P90745", "WBGene00007006", "O44731", "WBGene00018798", "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196", "species_29438", "species_74016", "species_113582", "species_419777", "species_29358", "species_113552", "species_70106", "species_216785", "species_380585", "CHEBI:28716", "species_390435", "CHEBI:28875", "CHEBI:53460", "CHEBI:27997", "CHEBI:16196", "species_2066763", "CHEBI:53487", "CHEBI:53486", "species_8934421", "CHEBI:53488", "CHEBI:28661", "CHEBI:28364", "CHEBI:27432", "species_29444", "species_29468", "species_29498", "species_417891", "species_209794", "species_209789", "species_158602", "species_8869214", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "A9Z1L1", "WBGene00005648", "G5ECY2", "WBGene00005644", "species_29460", "CHEBI:31011", "CHEBI:30772", "species_427486", "CHEBI:30768", "CHEBI:50122", "species_33549", "CHEBI:42504", "CHEBI:6498", "Q10651", "WBGene00000149", "species_372533", "species_266074", "species_266013", "CHEBI:15650", "species_266056", "CHEBI:17120", "species_209849", "species_390899", "CHEBI:15627", "species_879535", "species_265287" ] }, "reaction_10521878": { "compartment": "compartment_876", "id": "reaction_10521878", "reactome": "R-CEL-418582", "name": "G alpha (q) auto-inactivates by hydrolysing GTP to GDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508937" ], "products": [ "species_10509557" ], "modifiers": [ [ "species_10508937", "catalyst" ], [ "species_10521876", "catalyst" ] ], "additional_components": [ "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196", "species_29438", "species_29420", "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196", "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196", "species_29438", "P49808", "WBGene00004345", "Q18563", "WBGene00004349", "G5ECK9", "WBGene00004351", "Q23376", "WBGene00004352", "O45523", "WBGene00004353", "Q8WQC0", "WBGene00004350", "O45524", "WBGene00004354", "A0A5S9MNH1", "WBGene00004347" ] }, "reaction_10521559": { "compartment": "compartment_70101", "id": "reaction_10521559", "reactome": "R-CEL-416358", "name": "G alpha (q) inhibits PI3K alpha", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10506892", "species_10508937" ], "products": [ "species_10521557" ], "modifiers": [], "additional_components": [ "G5EDP9", "WBGene00000001", "Q94125", "WBGene00000090", "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196", "species_29438", "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196", "species_29438", "G5EDP9", "WBGene00000001", "Q94125", "WBGene00000090" ] }, "reaction_10509655": { "compartment": "compartment_876", "id": "reaction_10509655", "reactome": "R-CEL-114688", "name": "PLC-beta hydrolyses PIP2 to DAG and IP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509650" ], "products": [ "species_10509652" ], "modifiers": [ [ "species_10508939", "catalyst" ] ], "additional_components": [ "species_179856", "G5EBH0", "WBGene00001177", "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196", "species_29438", "species_114519", "species_114520", "G5EBH0", "WBGene00001177", "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196", "species_29438", "G5EBH0", "WBGene00001177", "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196", "species_29438" ] }, "reaction_10521563": { "compartment": "compartment_876", "id": "reaction_10521563", "reactome": "R-CEL-416516", "name": "GRK2 sequesters activated Gq", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509037", "species_10508937" ], "products": [ "species_10521561" ], "modifiers": [], "additional_components": [ "WBGene00001709", "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196", "species_29438", "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196", "species_29438", "Q09639", "WBGene00001709" ] }, "reaction_10528032": { "compartment": "compartment_876", "id": "reaction_10528032", "reactome": "R-CEL-750988", "name": "Inactive G alpha (z) reassociates with G beta:gamma", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10527902", "species_10509165" ], "products": [ "species_10527904" ], "modifiers": [], "additional_components": [ "O76584", "WBGene00001673", "P91907", "WBGene00001677", "Q20907", "WBGene00001670", "Q20910", "WBGene00001671", "Q21917", "WBGene00001669", "Q93743", "WBGene00001668", "Q9BIG2", "WBGene00001676", "species_29420", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "O76584", "WBGene00001673", "P91907", "WBGene00001677", "Q20907", "WBGene00001670", "Q20910", "WBGene00001671", "Q21917", "WBGene00001669", "Q93743", "WBGene00001668", "Q9BIG2", "WBGene00001676", "species_29420" ] }, "reaction_10570482": { "compartment": "compartment_876", "id": "reaction_10570482", "reactome": "R-CEL-8982018", "name": "G alpha (z):RGS complex dissociates to give inactive G alpha (z)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10570480" ], "products": [ "species_10527902", "species_10570434" ], "modifiers": [], "additional_components": [ "O76584", "WBGene00001673", "P91907", "WBGene00001677", "Q20907", "WBGene00001670", "Q20910", "WBGene00001671", "Q21917", "WBGene00001669", "Q93743", "WBGene00001668", "Q9BIG2", "WBGene00001676", "Q8WQC0", "WBGene00004350", "G5ECK9", "WBGene00004351", "O45523", "WBGene00004353", "O45524", "WBGene00004354", "Q18563", "WBGene00004349", "Q23376", "WBGene00004352", "species_29420", "O76584", "WBGene00001673", "P91907", "WBGene00001677", "Q20907", "WBGene00001670", "Q20910", "WBGene00001671", "Q21917", "WBGene00001669", "Q93743", "WBGene00001668", "Q9BIG2", "WBGene00001676", "species_29420", "Q8WQC0", "WBGene00004350", "G5ECK9", "WBGene00004351", "O45523", "WBGene00004353", "O45524", "WBGene00004354", "Q18563", "WBGene00004349", "Q23376", "WBGene00004352" ] }, "reaction_10527908": { "compartment": "compartment_876", "id": "reaction_10527908", "reactome": "R-CEL-749446", "name": "Liganded Gz-activating GPCRs bind inactive heterotrimeric G-protein Gz", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10519749", "species_10527904" ], "products": [ "species_10527906" ], "modifiers": [], "additional_components": [ "O02213", "WBGene00004777", "Q19084", "WBGene00017157", "species_209794", "species_209789", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "O76584", "WBGene00001673", "P91907", "WBGene00001677", "Q20907", "WBGene00001670", "Q20910", "WBGene00001671", "Q21917", "WBGene00001669", "Q93743", "WBGene00001668", "Q9BIG2", "WBGene00001676", "species_29420", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "O76584", "WBGene00001673", "P91907", "WBGene00001677", "Q20907", "WBGene00001670", "Q20910", "WBGene00001671", "Q21917", "WBGene00001669", "Q93743", "WBGene00001668", "Q9BIG2", "WBGene00001676", "species_29420", "O02213", "WBGene00004777", "Q19084", "WBGene00017157", "species_209794", "species_209789" ] }, "reaction_10521015": { "compartment": "compartment_876", "id": "reaction_10521015", "reactome": "R-CEL-392064", "name": "G alpha (z) inhibits adenylate cyclase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10521011", "species_10508992" ], "products": [ "species_10521013" ], "modifiers": [], "additional_components": [ "O76584", "WBGene00001673", "P91907", "WBGene00001677", "Q20907", "WBGene00001670", "Q20910", "WBGene00001671", "Q21917", "WBGene00001669", "Q93743", "WBGene00001668", "Q9BIG2", "WBGene00001676", "species_29438", "species_114632", "Q19523", "WBGene00000068", "O16880", "WBGene00000069", "G5EE33", "WBGene00000070", "Q966F9", "WBGene00000071", "species_114632", "Q19523", "WBGene00000068", "O16880", "WBGene00000069", "G5EE33", "WBGene00000070", "Q966F9", "WBGene00000071", "O76584", "WBGene00001673", "P91907", "WBGene00001677", "Q20907", "WBGene00001670", "Q20910", "WBGene00001671", "Q21917", "WBGene00001669", "Q93743", "WBGene00001668", "Q9BIG2", "WBGene00001676", "species_29438" ] }, "reaction_10570438": { "compartment": "compartment_876", "id": "reaction_10570438", "reactome": "R-CEL-8981892", "name": "Active G alpha (z) binds RGS proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10570434", "species_10521011" ], "products": [ "species_10570436" ], "modifiers": [], "additional_components": [ "Q8WQC0", "WBGene00004350", "G5ECK9", "WBGene00004351", "O45523", "WBGene00004353", "O45524", "WBGene00004354", "Q18563", "WBGene00004349", "Q23376", "WBGene00004352", "O76584", "WBGene00001673", "P91907", "WBGene00001677", "Q20907", "WBGene00001670", "Q20910", "WBGene00001671", "Q21917", "WBGene00001669", "Q93743", "WBGene00001668", "Q9BIG2", "WBGene00001676", "species_29438", "O76584", "WBGene00001673", "P91907", "WBGene00001677", "Q20907", "WBGene00001670", "Q20910", "WBGene00001671", "Q21917", "WBGene00001669", "Q93743", "WBGene00001668", "Q9BIG2", "WBGene00001676", "species_29438", "Q8WQC0", "WBGene00004350", "G5ECK9", "WBGene00004351", "O45523", "WBGene00004353", "O45524", "WBGene00004354", "Q18563", "WBGene00004349", "Q23376", "WBGene00004352" ] }, "reaction_10528026": { "compartment": "compartment_70101", "id": "reaction_10528026", "reactome": "R-CEL-749453", "name": "Liganded Gz-activating GPCR acts as a GEF for Gz", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10527906" ], "products": [ "species_29420", "species_10528023" ], "modifiers": [ [ "species_10527906", "catalyst" ] ], "additional_components": [ "P17343", "WBGene00001679", "P54406", "WBGene00001681", "O76584", "WBGene00001673", "P91907", "WBGene00001677", "Q20907", "WBGene00001670", "Q20910", "WBGene00001671", "Q21917", "WBGene00001669", "Q93743", "WBGene00001668", "Q9BIG2", "WBGene00001676", "species_29420", "O02213", "WBGene00004777", "Q19084", "WBGene00017157", "species_209794", "species_209789", "O76584", "WBGene00001673", "P91907", "WBGene00001677", "Q20907", "WBGene00001670", "Q20910", "WBGene00001671", "Q21917", "WBGene00001669", "Q93743", "WBGene00001668", "Q9BIG2", "WBGene00001676", "species_29438", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "O02213", "WBGene00004777", "Q19084", "WBGene00017157", "species_209794", "species_209789", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "O76584", "WBGene00001673", "P91907", "WBGene00001677", "Q20907", "WBGene00001670", "Q20910", "WBGene00001671", "Q21917", "WBGene00001669", "Q93743", "WBGene00001668", "Q9BIG2", "WBGene00001676", "species_29420", "O02213", "WBGene00004777", "Q19084", "WBGene00017157", "species_209794", "species_209789" ] }, "reaction_10528042": { "compartment": "compartment_984", "id": "reaction_10528042", "reactome": "R-CEL-751024", "name": "The Ligand:GPCR:Gz complex dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10528023" ], "products": [ "species_10509165", "species_390627", "species_10519747", "species_10521011" ], "modifiers": [], "additional_components": [ "O76584", "WBGene00001673", "P91907", "WBGene00001677", "Q20907", "WBGene00001670", "Q20910", "WBGene00001671", "Q21917", "WBGene00001669", "Q93743", "WBGene00001668", "Q9BIG2", "WBGene00001676", "species_29438", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "O02213", "WBGene00004777", "Q19084", "WBGene00017157", "species_209794", "species_209789", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "species_209794", "species_209789", "O02213", "WBGene00004777", "Q19084", "WBGene00017157", "O76584", "WBGene00001673", "P91907", "WBGene00001677", "Q20907", "WBGene00001670", "Q20910", "WBGene00001671", "Q21917", "WBGene00001669", "Q93743", "WBGene00001668", "Q9BIG2", "WBGene00001676", "species_29438" ] }, "reaction_10570492": { "compartment": "compartment_876", "id": "reaction_10570492", "reactome": "R-CEL-8982021", "name": "G alpha (z) in G alpha (z):RGS complex is inactivated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10570436" ], "products": [ "species_29372", "species_10570480" ], "modifiers": [ [ "species_10570436", "catalyst" ] ], "additional_components": [ "O76584", "WBGene00001673", "P91907", "WBGene00001677", "Q20907", "WBGene00001670", "Q20910", "WBGene00001671", "Q21917", "WBGene00001669", "Q93743", "WBGene00001668", "Q9BIG2", "WBGene00001676", "species_29438", "Q8WQC0", "WBGene00004350", "G5ECK9", "WBGene00004351", "O45523", "WBGene00004353", "O45524", "WBGene00004354", "Q18563", "WBGene00004349", "Q23376", "WBGene00004352", "O76584", "WBGene00001673", "P91907", "WBGene00001677", "Q20907", "WBGene00001670", "Q20910", "WBGene00001671", "Q21917", "WBGene00001669", "Q93743", "WBGene00001668", "Q9BIG2", "WBGene00001676", "Q8WQC0", "WBGene00004350", "G5ECK9", "WBGene00004351", "O45523", "WBGene00004353", "O45524", "WBGene00004354", "Q18563", "WBGene00004349", "Q23376", "WBGene00004352", "species_29420", "O76584", "WBGene00001673", "P91907", "WBGene00001677", "Q20907", "WBGene00001670", "Q20910", "WBGene00001671", "Q21917", "WBGene00001669", "Q93743", "WBGene00001668", "Q9BIG2", "WBGene00001676", "species_29438", "Q8WQC0", "WBGene00004350", "G5ECK9", "WBGene00004351", "O45523", "WBGene00004353", "O45524", "WBGene00004354", "Q18563", "WBGene00004349", "Q23376", "WBGene00004352" ] }, "reaction_10528049": { "compartment": "compartment_70101", "id": "reaction_10528049", "reactome": "R-CEL-751029", "name": "Liganded G12/13-activating GPCR acts as a GEF for G12/13", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10528044" ], "products": [ "species_29420", "species_10528038" ], "modifiers": [ [ "species_10528044", "catalyst" ] ], "additional_components": [ "species_29420", "Q19572", "WBGene00001674", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "species_209794", "species_209789", "G5EBX8", "WBGene00008890", "species_209794", "species_209789", "G5EBX8", "WBGene00008890", "Q19572", "WBGene00001674", "species_29438", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "species_29420", "Q19572", "WBGene00001674", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "species_209794", "species_209789", "G5EBX8", "WBGene00008890" ] }, "reaction_10509505": { "compartment": "compartment_70101", "id": "reaction_10509505", "reactome": "R-CEL-114544", "name": "p115-RhoGEF activation of RHOA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10509486" ], "products": [ "species_29420", "species_10509488" ], "modifiers": [ [ "species_10509502", "catalyst" ] ], "additional_components": [ "Q22038", "WBGene00004357", "species_29420", "Q22038", "WBGene00004357", "species_29438", "Q19572", "WBGene00001674", "species_29438", "G5EFE1", "WBGene00006468" ] }, "reaction_10521106": { "compartment": "compartment_876", "id": "reaction_10521106", "reactome": "R-CEL-398185", "name": "LARG binds plexin B1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10518605", "species_10521100" ], "products": [ "species_10521104" ], "modifiers": [], "additional_components": [ "O45657", "WBGene00004048", "U4PRY7", "WBGene00004047", "G5EFE1", "WBGene00006468", "H2L0P5", "WBGene00022391", "Q19572", "WBGene00001674", "species_29438", "G5EFE1", "WBGene00006468", "H2L0P5", "WBGene00022391", "Q19572", "WBGene00001674", "species_29438", "O45657", "WBGene00004048", "U4PRY7", "WBGene00004047" ] }, "reaction_10509507": { "compartment": "compartment_70101", "id": "reaction_10509507", "reactome": "R-CEL-114548", "name": "G alpha (13) activates Rho guanine nucleotide exchange factor 1 (p115-RhoGEF)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509500", "species_10509495" ], "products": [ "species_10509502" ], "modifiers": [], "additional_components": [ "WBGene00006468", "Q19572", "WBGene00001674", "species_29438", "Q19572", "WBGene00001674", "species_29438", "G5EFE1", "WBGene00006468" ] }, "reaction_10528051": { "compartment": "compartment_876", "id": "reaction_10528051", "reactome": "R-CEL-751039", "name": "Inactive G alpha (12/13) reassociates with G beta:gamma", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509165", "species_10521820" ], "products": [ "species_10509524" ], "modifiers": [], "additional_components": [ "P17343", "WBGene00001679", "P54406", "WBGene00001681", "species_29420", "Q19572", "WBGene00001674", "species_29420", "Q19572", "WBGene00001674", "P17343", "WBGene00001679", "P54406", "WBGene00001681" ] }, "reaction_10521958": { "compartment": "compartment_70101", "id": "reaction_10521958", "reactome": "R-CEL-419166", "name": "GEFs activate RhoA,B,C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10521599", "species_29438" ], "products": [ "species_29420", "species_10509488" ], "modifiers": [ [ "species_10516176", "catalyst" ] ], "additional_components": [ "species_29420", "Q22038", "WBGene00004357", "Q22038", "WBGene00004357", "species_29438", "G5EFE1", "WBGene00006468", "H2L0P5", "WBGene00022391", "G5EF62", "WBGene00009337", "Q9U3P2", "WBGene00007750", "X5LV34", "WBGene00001366", "S6EZU2", "WBGene00006476", "Q45FX5", "WBGene00006887", "Q21653", "WBGene00019832", "A0A0K3AQN0", "WBGene00013682", "O01847", "WBGene00015704", "Q965J0", "WBGene00019487", "Q21430", "WBGene00010776", "H2KYI7", "WBGene00006496", "Q9N5D3", "WBGene00004947", "Q9U364", "WBGene00002297", "A0A0K3AS36", "Y116A8C.36d", "Q19572", "WBGene00001674", "species_29438" ] }, "reaction_10528040": { "compartment": "compartment_984", "id": "reaction_10528040", "reactome": "R-CEL-751019", "name": "The Ligand:GPCR:G12/13 complex dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10528038" ], "products": [ "species_10509165", "species_10521096", "species_10519575", "species_791498" ], "modifiers": [], "additional_components": [ "species_209794", "species_209789", "G5EBX8", "WBGene00008890", "Q19572", "WBGene00001674", "species_29438", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "Q19572", "WBGene00001674", "species_29438", "WBGene00008890", "species_209794", "species_209789", "CHEBI:15627" ] }, "reaction_10528046": { "compartment": "compartment_876", "id": "reaction_10528046", "reactome": "R-CEL-751027", "name": "Liganded G12/13-activating GPCRs bind inactive heterotrimeric G-protein G12/13", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10519581", "species_10509524" ], "products": [ "species_10528044" ], "modifiers": [], "additional_components": [ "species_209794", "species_209789", "G5EBX8", "WBGene00008890", "species_29420", "Q19572", "WBGene00001674", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "species_29420", "Q19572", "WBGene00001674", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "species_209794", "species_209789", "G5EBX8", "WBGene00008890" ] }, "reaction_10521102": { "compartment": "compartment_70101", "id": "reaction_10521102", "reactome": "R-CEL-398184", "name": "LARG activation by G alpha 12/13", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10521096", "species_10516134" ], "products": [ "species_10521100" ], "modifiers": [], "additional_components": [ "Q19572", "WBGene00001674", "species_29438", "G5EFE1", "WBGene00006468", "H2L0P5", "WBGene00022391", "G5EFE1", "WBGene00006468", "H2L0P5", "WBGene00022391", "Q19572", "WBGene00001674", "species_29438" ] }, "reaction_10521823": { "compartment": "compartment_876", "id": "reaction_10521823", "reactome": "R-CEL-418574", "name": "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10521096" ], "products": [ "species_10521820" ], "modifiers": [ [ "species_10521096", "catalyst" ] ], "additional_components": [ "Q19572", "WBGene00001674", "species_29438", "species_29420", "Q19572", "WBGene00001674", "Q19572", "WBGene00001674", "species_29438" ] }, "reaction_10528246": { "compartment": "compartment_876", "id": "reaction_10528246", "reactome": "R-CEL-879674", "name": "CD97 binds CD55", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10528242", "species_10524688" ], "products": [ "species_10528244" ], "modifiers": [], "additional_components": [ "Q22328", "WBGene00002976", "A0A1N7SYP5", "WBGene00009500", "Q18849", "WBGene00009500", "WBGene00002252", "G5ECX0", "WBGene00002252", "Q22328", "WBGene00002976", "A0A1N7SYP5", "WBGene00009500", "Q18849", "WBGene00009500" ] }, "reaction_10524696": { "compartment": "compartment_984", "id": "reaction_10524696", "reactome": "R-CEL-444773", "name": "EGF-TM7 receptors bind chondroitin sulphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_444761", "species_10524686" ], "products": [ "species_10524694" ], "modifiers": [], "additional_components": [ "WBGene00002252", "G5ECX0", "WBGene00002252", "species_444761" ] }, "reaction_10518464": { "compartment": "compartment_984", "id": "reaction_10518464", "reactome": "R-CEL-373075", "name": "Metabotropic glutamate receptors bind glutamate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_210382", "species_10518460" ], "products": [ "species_10518462" ], "modifiers": [], "additional_components": [ "G5EG10", "WBGene00003233", "A1IMB8", "WBGene00021152", "Q09630", "WBGene00003232", "G5EG10", "WBGene00003233", "A1IMB8", "WBGene00021152", "Q09630", "WBGene00003232", "species_113552" ] }, "reaction_10522001": { "compartment": "compartment_876", "id": "reaction_10522001", "reactome": "R-CEL-420688", "name": "GABAB heterodimeric receptor binds GABA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352003", "species_10519829" ], "products": [ "species_10519831" ], "modifiers": [], "additional_components": [ "G5ECB2", "WBGene00022675", "H2L0Q3", "WBGene00021528", "G5ECB2", "WBGene00022675", "H2L0Q3", "WBGene00021528", "species_352003" ] }, "reaction_10524672": { "compartment": "compartment_984", "id": "reaction_10524672", "reactome": "R-CEL-444654", "name": "G-protein coupled bile acid receptor binds lithocholic acid", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_444840", "species_10524668" ], "products": [ "species_10524670" ], "modifiers": [], "additional_components": [ "species_5357505", "species_193451", "species_176655", "CHEBI:16755", "Q10042", "WBGene00019287", "Q19295", "WBGene00019287", "Q19779", "WBGene00017779", "Q1ZXT2", "WBGene00011878", "Q10042", "WBGene00019287", "Q19295", "WBGene00019287", "Q19779", "WBGene00017779", "Q1ZXT2", "WBGene00011878", "species_5357505", "species_193451", "species_176655", "CHEBI:16755" ] }, "reaction_10563088": { "compartment": "compartment_984", "id": "reaction_10563088", "reactome": "R-CEL-6805205", "name": "GPR35 binds kynurenic acid", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10563084", "species_6805204" ], "products": [ "species_10563086" ], "modifiers": [], "additional_components": [ "WBGene00016570", "species_6805204", "H2KZ99", "WBGene00016570" ] }, "reaction_10520929": { "compartment": "compartment_984", "id": "reaction_10520929", "reactome": "R-CEL-391934", "name": "DP2 receptor can bind PGD2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_416911", "species_10519813" ], "products": [ "species_10519815" ], "modifiers": [], "additional_components": [ "Q23033", "WBGene00020086", "A0A0K3AXD3", "WBGene00011372", "Q9XVQ0", "WBGene00018089", "A0A2C9C3A4", "WBGene00018089", "A0A3B1DQQ4", "WBGene00006864", "H9G358", "WBGene00018089", "P34311", "WBGene00018089", "Q09502", "WBGene00008065", "Q20841", "WBGene00018886", "Q23033", "WBGene00020086", "A0A0K3AXD3", "WBGene00011372", "Q9XVQ0", "WBGene00018089", "A0A2C9C3A4", "WBGene00018089", "A0A3B1DQQ4", "WBGene00006864", "H9G358", "WBGene00018089", "P34311", "WBGene00018089", "Q09502", "WBGene00008065", "Q20841", "WBGene00018886", "species_879629" ] }, "reaction_10520931": { "compartment": "compartment_984", "id": "reaction_10520931", "reactome": "R-CEL-391937", "name": "UDP/CysLT receptor can bind cysteinyl leukotrienes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10519635", "species_416372" ], "products": [ "species_10519793" ], "modifiers": [], "additional_components": [ "WBGene00016570", "species_266074", "species_266013", "CHEBI:15650", "species_266074", "species_266013", "CHEBI:15650", "H2KZ99", "WBGene00016570" ] }, "reaction_10520933": { "compartment": "compartment_984", "id": "reaction_10520933", "reactome": "R-CEL-391941", "name": "BLT receptors can bind LTB4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10519651", "species_416436" ], "products": [ "species_10519653" ], "modifiers": [], "additional_components": [ "Q20325", "WBGene00018344", "Q9XUK8", "WBGene00012275", "species_266056", "Q20325", "WBGene00018344", "Q9XUK8", "WBGene00012275" ] }, "reaction_10520935": { "compartment": "compartment_984", "id": "reaction_10520935", "reactome": "R-CEL-391943", "name": "CYSLT2 binds LTC4,LTD4,LTE4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10519631", "species_416372" ], "products": [ "species_10519633" ], "modifiers": [], "additional_components": [ "Q20325", "WBGene00018344", "Q9XUK8", "WBGene00012275", "species_266074", "species_266013", "CHEBI:15650", "species_266074", "species_266013", "CHEBI:15650", "Q20325", "WBGene00018344", "Q9XUK8", "WBGene00012275" ] }, "reaction_10573113": { "compartment": "compartment_984", "id": "reaction_10573113", "reactome": "R-CEL-9684627", "name": "CYSLTR1 binds CYSLTR1 antagonists", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10519623", "species_9684615" ], "products": [ "species_10573111" ], "modifiers": [], "additional_components": [ "Q20325", "WBGene00018344", "Q9XUK8", "WBGene00012275", "Q20325", "WBGene00018344", "Q9XUK8", "WBGene00012275" ] }, "reaction_10573117": { "compartment": "compartment_984", "id": "reaction_10573117", "reactome": "R-CEL-9690439", "name": "CYSLTR1 binds LTC4,LTD4,LTE4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10519623", "species_416372" ], "products": [ "species_10519625" ], "modifiers": [ [ "species_10573111", "inhibitor" ] ], "additional_components": [ "Q20325", "WBGene00018344", "Q9XUK8", "WBGene00012275", "species_266074", "species_266013", "CHEBI:15650", "species_266074", "species_266013", "CHEBI:15650", "Q20325", "WBGene00018344", "Q9XUK8", "WBGene00012275", "Q20325", "WBGene00018344", "Q9XUK8", "WBGene00012275" ] }, "reaction_10521905": { "compartment": "compartment_984", "id": "reaction_10521905", "reactome": "R-CEL-418918", "name": "The UDP/CysLT (P2Y17) receptor can bind UTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_417888", "species_10519635" ], "products": [ "species_10519637" ], "modifiers": [], "additional_components": [ "WBGene00016570", "H2KZ99", "WBGene00016570", "species_158602" ] }, "reaction_10521699": { "compartment": "compartment_984", "id": "reaction_10521699", "reactome": "R-CEL-417820", "name": "P2Y9 receptor can bind to LPA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10519598", "species_417891" ], "products": [ "species_10519600" ], "modifiers": [], "additional_components": [ "WBGene00016570", "species_417891", "H2KZ99", "WBGene00016570" ] }, "reaction_10521701": { "compartment": "compartment_984", "id": "reaction_10521701", "reactome": "R-CEL-417842", "name": "P2Y10 receptor can bind to LPA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_417891", "species_10519602" ], "products": [ "species_10519604" ], "modifiers": [], "additional_components": [ "WBGene00016570", "H2KZ99", "WBGene00016570", "species_417891" ] }, "reaction_10521703": { "compartment": "compartment_984", "id": "reaction_10521703", "reactome": "R-CEL-417890", "name": "P2Y5 receptor can bind to LPA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10519594", "species_417891" ], "products": [ "species_10519596" ], "modifiers": [], "additional_components": [ "WBGene00016570", "species_417891", "H2KZ99", "WBGene00016570" ] }, "reaction_10521923": { "compartment": "compartment_984", "id": "reaction_10521923", "reactome": "R-CEL-418925", "name": "ADORA2A,B bind Ade-Rib", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10521919", "species_83908" ], "products": [ "species_10521921" ], "modifiers": [], "additional_components": [ "Q10042", "WBGene00019287", "Q19295", "WBGene00019287", "Q19779", "WBGene00017779", "Q1ZXT2", "WBGene00011878", "species_83909", "Q10042", "WBGene00019287", "Q19295", "WBGene00019287", "Q19779", "WBGene00017779", "Q1ZXT2", "WBGene00011878" ] }, "reaction_10521903": { "compartment": "compartment_984", "id": "reaction_10521903", "reactome": "R-CEL-418904", "name": "A1 and A3 receptors bind adenosine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10519789", "species_83908" ], "products": [ "species_10519791" ], "modifiers": [], "additional_components": [ "Q10042", "WBGene00019287", "Q19295", "WBGene00019287", "Q19779", "WBGene00017779", "Q1ZXT2", "WBGene00011878", "species_83909", "Q10042", "WBGene00019287", "Q19295", "WBGene00019287", "Q19779", "WBGene00017779", "Q1ZXT2", "WBGene00011878" ] }, "reaction_10524681": { "compartment": "compartment_984", "id": "reaction_10524681", "reactome": "R-CEL-444731", "name": "GPR4, GPR65, GPR132 and OGR1 are pH sensing receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_10519655" ], "products": [ "species_10519659" ], "modifiers": [], "additional_components": [ "WBGene00016570", "H2KZ99", "WBGene00016570", "species_70106" ] }, "reaction_10521965": { "compartment": "compartment_984", "id": "reaction_10521965", "reactome": "R-CEL-419861", "name": "Melanospin is stimulated by light", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10519609", "species_419777" ], "products": [ "species_10519611" ], "modifiers": [], "additional_components": [ "WBGene00007006", "species_419777", "P90745", "WBGene00007006" ] }, "reaction_10520833": { "compartment": "compartment_984", "id": "reaction_10520833", "reactome": "R-CEL-390673", "name": "CHRM2,4 bind acetylcholine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10519751", "species_372533" ], "products": [ "species_10519755" ], "modifiers": [], "additional_components": [ "WBGene00001519", "species_372533", "Q9U7D5", "WBGene00001519" ] }, "reaction_10520829": { "compartment": "compartment_984", "id": "reaction_10520829", "reactome": "R-CEL-390649", "name": "CHRM1,3,5 bind acetylcholine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10519564", "species_372533" ], "products": [ "species_10519570" ], "modifiers": [], "additional_components": [ "WBGene00001519", "species_372533", "Q9U7D5", "WBGene00001519" ] }, "reaction_10572915": { "compartment": "compartment_984", "id": "reaction_10572915", "reactome": "R-CEL-9656244", "name": "DRD2 binds DA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10572911", "species_380873" ], "products": [ "species_10572913" ], "modifiers": [], "additional_components": [ "WBGene00020506", "species_351601", "Q6RYS9", "WBGene00020506" ] }, "reaction_10520835": { "compartment": "compartment_984", "id": "reaction_10520835", "reactome": "R-CEL-390846", "name": "D2D3,4 bind to DA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10519725", "species_380873" ], "products": [ "species_10519727" ], "modifiers": [], "additional_components": [ "Q6RYS9", "WBGene00020506", "E7EM37", "WBGene00001053", "G5EGH0", "WBGene00004779", "species_351601", "Q6RYS9", "WBGene00020506", "E7EM37", "WBGene00001053", "G5EGH0", "WBGene00004779" ] }, "reaction_10520837": { "compartment": "compartment_984", "id": "reaction_10520837", "reactome": "R-CEL-390886", "name": "HRH4 binds Hist", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10519710", "species_390899" ], "products": [ "species_10519712" ], "modifiers": [], "additional_components": [ "WBGene00001519", "species_390899", "Q9U7D5", "WBGene00001519" ] }, "reaction_10520846": { "compartment": "compartment_984", "id": "reaction_10520846", "reactome": "R-CEL-390909", "name": "HRH2 binds hist", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10520842", "species_390899" ], "products": [ "species_10520844" ], "modifiers": [], "additional_components": [ "WBGene00011382", "species_390899", "O45732", "WBGene00011382" ] }, "reaction_10573135": { "compartment": "compartment_984", "id": "reaction_10573135", "reactome": "R-CEL-9692880", "name": "HRH3 binds Hist", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10573131", "species_390899" ], "products": [ "species_10573133" ], "modifiers": [], "additional_components": [ "WBGene00001519", "species_390899", "Q9U7D5", "WBGene00001519" ] }, "reaction_10520848": { "compartment": "compartment_984", "id": "reaction_10520848", "reactome": "R-CEL-390929", "name": "HTR1 and 5A receptors can bind serotonin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_114523", "species_10519706" ], "products": [ "species_10519708" ], "modifiers": [], "additional_components": [ "Q7JP61", "WBGene00006411", "E7EM37", "WBGene00001053", "G5EGH0", "WBGene00004779", "Q7JP61", "WBGene00006411", "E7EM37", "WBGene00001053", "G5EGH0", "WBGene00004779", "species_380585" ] }, "reaction_10520865": { "compartment": "compartment_984", "id": "reaction_10520865", "reactome": "R-CEL-390931", "name": "5-HT4, 6 and 7 receptors can bind serotonin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10520861", "species_114523" ], "products": [ "species_10520863" ], "modifiers": [], "additional_components": [ "O45732", "WBGene00011382", "Q86ME6", "WBGene00001052", "Q22895", "WBGene00004780", "species_380585", "O45732", "WBGene00011382", "Q86ME6", "WBGene00001052", "Q22895", "WBGene00004780" ] }, "reaction_10520850": { "compartment": "compartment_984", "id": "reaction_10520850", "reactome": "R-CEL-390930", "name": "5-HT2 receptor can bind serotonin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_114523", "species_10519586" ], "products": [ "species_10519592" ], "modifiers": [], "additional_components": [ "WBGene00016037", "P91096", "WBGene00016037", "species_380585" ] }, "reaction_10573212": { "compartment": "compartment_984", "id": "reaction_10573212", "reactome": "R-CEL-9693347", "name": "HTR1A binds 5HT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_114523", "species_10573208" ], "products": [ "species_10573210" ], "modifiers": [], "additional_components": [ "WBGene00004779", "G5EGH0", "WBGene00004779", "species_380585" ] }, "reaction_10555425": { "compartment": "compartment_70101", "id": "reaction_10555425", "reactome": "R-CEL-5681981", "name": "ATG3 transfers LC3 from ATG7 to ATG3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10555420" ], "products": [ "species_10555422" ], "modifiers": [ [ "species_10555420", "catalyst" ] ], "additional_components": [ "Q9N369", "WBGene00021922", "G5EBK4", "WBGene00010882", "Q23536", "WBGene00002981", "Q09490", "WBGene00002980", "Q9N369", "WBGene00021922", "Q23536", "WBGene00002981", "Q09490", "WBGene00002980", "G5EBK4", "WBGene00010882", "Q9N369", "WBGene00021922", "G5EBK4", "WBGene00010882", "Q23536", "WBGene00002981", "Q09490", "WBGene00002980" ] }, "reaction_10555489": { "compartment": "compartment_5683628", "id": "reaction_10555489", "reactome": "R-CEL-5682388", "name": "Autophagosome maturation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10555350" ], "products": [ "species_10555480" ], "modifiers": [ [ "species_10555487", "catalyst" ], [ "species_10529080", "catalyst" ] ], "additional_components": [ "species_8959490", "Q23536", "WBGene00002981", "Q09490", "WBGene00002980", "Q23536", "WBGene00002981", "Q09490", "WBGene00002980", "species_8959490", "Q9TXI7", "WBGene00006932", "Q22592", "WBGene00000247", "Q23669", "WBGene00014151", "A7DT33", "WBGene00021319", "Q9GYK4", "WBGene00020866", "Q9BL60", "WBGene00022027", "Q9U2F6", "WBGene00012903", "O02208", "WBGene00007216", "Q22718", "WBGene00011976", "Q18886", "WBGene00016961", "Q21959", "WBGene00020025" ] }, "reaction_10554859": { "compartment": "compartment_70101", "id": "reaction_10554859", "reactome": "R-CEL-5672008", "name": "Thr-180 of ULK1 is phosphorylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10554667", "species_113592" ], "products": [ "species_29370", "species_10554856" ], "modifiers": [ [ "species_10554667", "catalyst" ] ], "additional_components": [ "species_76577", "Q9XUY2", "WBGene00010115", "P45894", "WBGene00019801", "Q95ZQ4", "WBGene00020142", "A0A1T5HUK9", "WBGene00013732", "H2L0K0", "WBGene00020135", "O02168", "WBGene00020633", "Q9N501", "WBGene00021527", "Q22342", "WBGene00020334", "Q23023", "WBGene00006786", "Q95XH2", "WBGene00022078", "P34379", "WBGene00017045", "species_76577", "Q9XUY2", "WBGene00010115", "P45894", "WBGene00019801", "Q95ZQ4", "WBGene00020142", "A0A1T5HUK9", "WBGene00013732", "H2L0K0", "WBGene00020135", "O02168", "WBGene00020633", "Q9N501", "WBGene00021527", "Q22342", "WBGene00020334", "Q23023", "WBGene00006786", "Q95XH2", "WBGene00022078", "P34379", "WBGene00017045", "species_76577", "Q9XUY2", "WBGene00010115", "P45894", "WBGene00019801", "Q95ZQ4", "WBGene00020142", "A0A1T5HUK9", "WBGene00013732", "H2L0K0", "WBGene00020135", "O02168", "WBGene00020633", "Q9N501", "WBGene00021527", "Q22342", "WBGene00020334", "Q23023", "WBGene00006786", "Q95XH2", "WBGene00022078", "P34379", "WBGene00017045" ] }, "reaction_10571498": { "compartment": "compartment_70101", "id": "reaction_10571498", "reactome": "R-CEL-9020616", "name": "ATG12 forms a thioester bond with ATG7 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10555409" ], "products": [ "species_10555535" ], "modifiers": [], "additional_components": [ "Q10931", "WBGene00002982", "G5EBK4", "WBGene00010882", "Q10931", "WBGene00002982", "G5EBK4", "WBGene00010882" ] }, "reaction_10555247": { "compartment": "compartment_74700", "id": "reaction_10555247", "reactome": "R-CEL-5675790", "name": "MTORC1 dissociates from ULK complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10555091" ], "products": [ "species_10510623", "species_10554866" ], "modifiers": [], "additional_components": [ "Q22342", "WBGene00020334", "Q23023", "WBGene00006786", "Q95XH2", "WBGene00022078", "P34379", "WBGene00017045", "P34443", "WBGene00010038", "species_29438", "Q19425", "WBGene00008774", "species_29420", "G5EGB3", "WBGene00012497", "Q22743", "WBGene00006414", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "P91040", "WBGene00015697", "Q95Q95", "WBGene00002583", "Q68TI8", "WBGene00000911", "P34443", "WBGene00010038", "species_29438", "Q19425", "WBGene00008774", "species_29420", "G5EGB3", "WBGene00012497", "Q22743", "WBGene00006414", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "P91040", "WBGene00015697", "Q95Q95", "WBGene00002583", "Q68TI8", "WBGene00000911", "Q22342", "WBGene00020334", "Q23023", "WBGene00006786", "Q95XH2", "WBGene00022078", "P34379", "WBGene00017045" ] }, "reaction_10555567": { "compartment": "compartment_70101", "id": "reaction_10555567", "reactome": "R-CEL-5683593", "name": "ATG7:ATG3:LC3 dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10555422" ], "products": [ "species_10555407", "species_10555348" ], "modifiers": [], "additional_components": [ "Q9N369", "WBGene00021922", "Q23536", "WBGene00002981", "Q09490", "WBGene00002980", "G5EBK4", "WBGene00010882", "G5EBK4", "WBGene00010882", "Q9N369", "WBGene00021922", "Q23536", "WBGene00002981", "Q09490", "WBGene00002980" ] }, "reaction_10554670": { "compartment": "compartment_70101", "id": "reaction_10554670", "reactome": "R-CEL-5665868", "name": "AMPK (complex) phosphorylates ULK1 (complex)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10554661" ], "products": [ "species_29370", "species_10554667" ], "modifiers": [ [ "species_10554661", "catalyst" ] ], "additional_components": [ "Q22342", "WBGene00020334", "Q23023", "WBGene00006786", "Q95XH2", "WBGene00022078", "P34379", "WBGene00017045", "species_76577", "Q9XUY2", "WBGene00010115", "P45894", "WBGene00019801", "Q95ZQ4", "WBGene00020142", "A0A1T5HUK9", "WBGene00013732", "H2L0K0", "WBGene00020135", "O02168", "WBGene00020633", "Q9N501", "WBGene00021527", "species_76577", "Q9XUY2", "WBGene00010115", "P45894", "WBGene00019801", "Q95ZQ4", "WBGene00020142", "A0A1T5HUK9", "WBGene00013732", "H2L0K0", "WBGene00020135", "O02168", "WBGene00020633", "Q9N501", "WBGene00021527", "Q22342", "WBGene00020334", "Q23023", "WBGene00006786", "Q95XH2", "WBGene00022078", "P34379", "WBGene00017045", "Q22342", "WBGene00020334", "Q23023", "WBGene00006786", "Q95XH2", "WBGene00022078", "P34379", "WBGene00017045", "species_76577", "Q9XUY2", "WBGene00010115", "P45894", "WBGene00019801", "Q95ZQ4", "WBGene00020142", "A0A1T5HUK9", "WBGene00013732", "H2L0K0", "WBGene00020135", "O02168", "WBGene00020633", "Q9N501", "WBGene00021527" ] }, "reaction_10555380": { "compartment": "compartment_70101", "id": "reaction_10555380", "reactome": "R-CEL-5678490", "name": "ATG16L1 complex transfers LC3 from ATG3 to PE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5681998", "species_10555348" ], "products": [ "species_10555352", "species_10555350" ], "modifiers": [ [ "species_10555377", "catalyst" ] ], "additional_components": [ "Q9N369", "WBGene00021922", "Q23536", "WBGene00002981", "Q09490", "WBGene00002980", "WBGene00021922", "species_8959490", "Q23536", "WBGene00002981", "Q09490", "WBGene00002980", "Q19124", "WBGene00017178", "Q09406", "WBGene00019427", "Q10931", "WBGene00002982", "Q3V5I7", "WBGene00022152", "O16466", "WBGene00018294", "species_5334668" ] }, "reaction_10554871": { "compartment": "compartment_17938", "id": "reaction_10554871", "reactome": "R-CEL-5672010", "name": "Active MTORC1 phosphorylates ULK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10554861", "species_113592" ], "products": [ "species_29370", "species_10554868" ], "modifiers": [ [ "species_10554861", "catalyst" ] ], "additional_components": [ "Q22342", "WBGene00020334", "Q23023", "WBGene00006786", "Q95XH2", "WBGene00022078", "P34379", "WBGene00017045", "Q19425", "WBGene00008774", "species_29420", "G5EGB3", "WBGene00012497", "Q22743", "WBGene00006414", "species_29438", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "P91040", "WBGene00015697", "Q95Q95", "WBGene00002583", "Q68TI8", "WBGene00000911", "P34443", "WBGene00010038", "Q22342", "WBGene00020334", "Q23023", "WBGene00006786", "Q95XH2", "WBGene00022078", "P34379", "WBGene00017045", "Q19425", "WBGene00008774", "species_29420", "G5EGB3", "WBGene00012497", "Q22743", "WBGene00006414", "species_29438", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "P91040", "WBGene00015697", "Q95Q95", "WBGene00002583", "Q68TI8", "WBGene00000911", "P34443", "WBGene00010038", "Q22342", "WBGene00020334", "Q23023", "WBGene00006786", "Q95XH2", "WBGene00022078", "P34379", "WBGene00017045", "Q19425", "WBGene00008774", "species_29420", "G5EGB3", "WBGene00012497", "Q22743", "WBGene00006414", "species_29438", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "P91040", "WBGene00015697", "Q95Q95", "WBGene00002583", "Q68TI8", "WBGene00000911", "P34443", "WBGene00010038" ] }, "reaction_10554873": { "compartment": "compartment_70101", "id": "reaction_10554873", "reactome": "R-CEL-5672011", "name": "p-AMPK:AMP binds the ULK complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10554659", "species_10519954" ], "products": [ "species_10554661" ], "modifiers": [], "additional_components": [ "Q22342", "WBGene00020334", "Q23023", "WBGene00006786", "Q95XH2", "WBGene00022078", "P34379", "WBGene00017045", "species_76577", "Q9XUY2", "WBGene00010115", "P45894", "WBGene00019801", "Q95ZQ4", "WBGene00020142", "A0A1T5HUK9", "WBGene00013732", "H2L0K0", "WBGene00020135", "O02168", "WBGene00020633", "Q9N501", "WBGene00021527", "Q22342", "WBGene00020334", "Q23023", "WBGene00006786", "Q95XH2", "WBGene00022078", "P34379", "WBGene00017045", "species_76577", "Q9XUY2", "WBGene00010115", "P45894", "WBGene00019801", "Q95ZQ4", "WBGene00020142", "A0A1T5HUK9", "WBGene00013732", "H2L0K0", "WBGene00020135", "O02168", "WBGene00020633", "Q9N501", "WBGene00021527" ] }, "reaction_10555259": { "compartment": "compartment_70101", "id": "reaction_10555259", "reactome": "R-CEL-5675868", "name": "ULK1 phosphorylates ATG13 and RB1CC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10554856" ], "products": [ "species_29370", "species_10555256" ], "modifiers": [ [ "species_10554856", "catalyst" ] ], "additional_components": [ "species_76577", "Q9XUY2", "WBGene00010115", "P45894", "WBGene00019801", "Q95ZQ4", "WBGene00020142", "A0A1T5HUK9", "WBGene00013732", "H2L0K0", "WBGene00020135", "O02168", "WBGene00020633", "Q9N501", "WBGene00021527", "Q22342", "WBGene00020334", "Q23023", "WBGene00006786", "Q95XH2", "WBGene00022078", "P34379", "WBGene00017045", "species_76577", "Q9XUY2", "WBGene00010115", "P45894", "WBGene00019801", "Q95ZQ4", "WBGene00020142", "A0A1T5HUK9", "WBGene00013732", "H2L0K0", "WBGene00020135", "O02168", "WBGene00020633", "Q9N501", "WBGene00021527", "P34379", "WBGene00017045", "Q23023", "WBGene00006786", "Q22342", "WBGene00020334", "Q95XH2", "WBGene00022078", "species_76577", "Q9XUY2", "WBGene00010115", "P45894", "WBGene00019801", "Q95ZQ4", "WBGene00020142", "A0A1T5HUK9", "WBGene00013732", "H2L0K0", "WBGene00020135", "O02168", "WBGene00020633", "Q9N501", "WBGene00021527", "Q22342", "WBGene00020334", "Q23023", "WBGene00006786", "Q95XH2", "WBGene00022078", "P34379", "WBGene00017045" ] }, "reaction_10555452": { "compartment": "compartment_70101", "id": "reaction_10555452", "reactome": "R-CEL-5681987", "name": "LC3 is cleaved by ATG4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10555433" ], "products": [ "species_10555340" ], "modifiers": [ [ "species_10555449", "catalyst" ] ], "additional_components": [ "Q23536", "WBGene00002981", "Q09490", "WBGene00002980", "Q23536", "WBGene00002981", "Q09490", "WBGene00002980", "K8ESC5", "WBGene00013595" ] }, "reaction_10555454": { "compartment": "compartment_70101", "id": "reaction_10555454", "reactome": "R-CEL-5682011", "name": "LC3 binds ATG7 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10555407", "species_10555340" ], "products": [ "species_10555418" ], "modifiers": [], "additional_components": [ "G5EBK4", "WBGene00010882", "Q23536", "WBGene00002981", "Q09490", "WBGene00002980", "G5EBK4", "WBGene00010882", "Q23536", "WBGene00002981", "Q09490", "WBGene00002980" ] }, "reaction_10555456": { "compartment": "compartment_70101", "id": "reaction_10555456", "reactome": "R-CEL-5682377", "name": "LC3 de-lipidation by ATG4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10555350" ], "products": [ "species_10555340", "species_5681998" ], "modifiers": [ [ "species_10555449", "catalyst" ] ], "additional_components": [ "species_8959490", "Q23536", "WBGene00002981", "Q09490", "WBGene00002980", "Q23536", "WBGene00002981", "Q09490", "WBGene00002980", "K8ESC5", "WBGene00013595" ] }, "reaction_10536642": { "compartment": "compartment_70101", "id": "reaction_10536642", "reactome": "R-CEL-1632857", "name": "ULK1 phosphorylates AMBRA1:BECN1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10536602", "species_113592" ], "products": [ "species_29370", "species_10536608" ], "modifiers": [ [ "species_10536639", "catalyst" ] ], "additional_components": [ "Q9XWQ4", "WBGene00013695", "Q9TXI7", "WBGene00006932", "Q22592", "WBGene00000247", "Q23669", "WBGene00014151", "Q65XS9", "WBGene00043067", "A0AAC1", "WBGene00012424", "Q7YTJ8", "WBGene00012425", "Q21557", "WBGene00010888", "Q22799", "WBGene00001005", "Q9XWQ4", "WBGene00013695", "Q9TXI7", "WBGene00006932", "Q22592", "WBGene00000247", "Q23669", "WBGene00014151", "Q65XS9", "WBGene00043067", "A0AAC1", "WBGene00012424", "Q7YTJ8", "WBGene00012425", "Q21557", "WBGene00010888", "Q22799", "WBGene00001005", "species_76577", "Q9XUY2", "WBGene00010115", "P45894", "WBGene00019801", "Q95ZQ4", "WBGene00020142", "A0A1T5HUK9", "WBGene00013732", "H2L0K0", "WBGene00020135", "O02168", "WBGene00020633", "Q9N501", "WBGene00021527", "Q22342", "WBGene00020334", "Q95XH2", "WBGene00022078", "P34379", "WBGene00017045", "Q23023", "WBGene00006786" ] }, "reaction_10554883": { "compartment": "compartment_12045", "id": "reaction_10554883", "reactome": "R-CEL-5672012", "name": "Beclin-1 complex phosphorylates PtdIns", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_426639" ], "products": [ "species_29370", "species_5676030" ], "modifiers": [ [ "species_10554880", "catalyst" ] ], "additional_components": [ "Q9TXI7", "WBGene00006932", "Q23669", "WBGene00014151", "Q9XWQ4", "WBGene00013695", "Q22592", "WBGene00000247" ] }, "reaction_10555396": { "compartment": "compartment_70101", "id": "reaction_10555396", "reactome": "R-CEL-5679205", "name": "ULK1 phosphorylates Beclin-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10555394" ], "products": [ "species_29370", "species_10554880" ], "modifiers": [ [ "species_10536639", "catalyst" ] ], "additional_components": [ "Q9TXI7", "WBGene00006932", "Q22592", "WBGene00000247", "Q23669", "WBGene00014151", "Q9XWQ4", "WBGene00013695", "Q9TXI7", "WBGene00006932", "Q23669", "WBGene00014151", "Q9XWQ4", "WBGene00013695", "Q22592", "WBGene00000247", "species_76577", "Q9XUY2", "WBGene00010115", "P45894", "WBGene00019801", "Q95ZQ4", "WBGene00020142", "A0A1T5HUK9", "WBGene00013732", "H2L0K0", "WBGene00020135", "O02168", "WBGene00020633", "Q9N501", "WBGene00021527", "Q22342", "WBGene00020334", "Q95XH2", "WBGene00022078", "P34379", "WBGene00017045", "Q23023", "WBGene00006786" ] }, "reaction_10554887": { "compartment": "compartment_17938", "id": "reaction_10554887", "reactome": "R-CEL-5672017", "name": "Rheb in the MTORC1 complex hydrolyses GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10510588" ], "products": [ "species_10519963" ], "modifiers": [ [ "species_10510588", "catalyst" ] ], "additional_components": [ "Q19425", "WBGene00008774", "species_29420", "G5EGB3", "WBGene00012497", "Q22743", "WBGene00006414", "species_29438", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "P91040", "WBGene00015697", "Q95Q95", "WBGene00002583", "Q68TI8", "WBGene00000911", "P34443", "WBGene00010038", "P34443", "WBGene00010038", "species_29420", "Q19425", "WBGene00008774", "G5EGB3", "WBGene00012497", "Q22743", "WBGene00006414", "species_29438", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "P91040", "WBGene00015697", "Q95Q95", "WBGene00002583", "Q68TI8", "WBGene00000911", "Q19425", "WBGene00008774", "species_29420", "G5EGB3", "WBGene00012497", "Q22743", "WBGene00006414", "species_29438", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "P91040", "WBGene00015697", "Q95Q95", "WBGene00002583", "Q68TI8", "WBGene00000911", "P34443", "WBGene00010038" ] }, "reaction_10555399": { "compartment": "compartment_70101", "id": "reaction_10555399", "reactome": "R-CEL-5679206", "name": "MTMR14, MTMR3 dephosphorylate PI3P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5676030" ], "products": [ "species_426639" ], "modifiers": [ [ "species_10537226", "catalyst" ] ], "additional_components": [ "WBGene00003476" ] }, "reaction_10555401": { "compartment": "compartment_70101", "id": "reaction_10555401", "reactome": "R-CEL-5679239", "name": "ULK complex translocates to the ER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10555256" ], "products": [ "species_10536639" ], "modifiers": [], "additional_components": [ "species_76577", "Q9XUY2", "WBGene00010115", "P45894", "WBGene00019801", "Q95ZQ4", "WBGene00020142", "A0A1T5HUK9", "WBGene00013732", "H2L0K0", "WBGene00020135", "O02168", "WBGene00020633", "Q9N501", "WBGene00021527", "P34379", "WBGene00017045", "Q23023", "WBGene00006786", "Q22342", "WBGene00020334", "Q95XH2", "WBGene00022078", "species_76577", "Q9XUY2", "WBGene00010115", "P45894", "WBGene00019801", "Q95ZQ4", "WBGene00020142", "A0A1T5HUK9", "WBGene00013732", "H2L0K0", "WBGene00020135", "O02168", "WBGene00020633", "Q9N501", "WBGene00021527", "Q22342", "WBGene00020334", "Q95XH2", "WBGene00022078", "P34379", "WBGene00017045", "Q23023", "WBGene00006786" ] }, "reaction_10554891": { "compartment": "compartment_70101", "id": "reaction_10554891", "reactome": "R-CEL-5672817", "name": "Active MTORC1 binds the ULK1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10510588", "species_10554659" ], "products": [ "species_10554861" ], "modifiers": [], "additional_components": [ "Q19425", "WBGene00008774", "species_29420", "G5EGB3", "WBGene00012497", "Q22743", "WBGene00006414", "species_29438", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "P91040", "WBGene00015697", "Q95Q95", "WBGene00002583", "Q68TI8", "WBGene00000911", "P34443", "WBGene00010038", "Q22342", "WBGene00020334", "Q23023", "WBGene00006786", "Q95XH2", "WBGene00022078", "P34379", "WBGene00017045", "Q22342", "WBGene00020334", "Q23023", "WBGene00006786", "Q95XH2", "WBGene00022078", "P34379", "WBGene00017045", "Q19425", "WBGene00008774", "species_29420", "G5EGB3", "WBGene00012497", "Q22743", "WBGene00006414", "species_29438", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "P91040", "WBGene00015697", "Q95Q95", "WBGene00002583", "Q68TI8", "WBGene00000911", "P34443", "WBGene00010038" ] }, "reaction_10555403": { "compartment": "compartment_70101", "id": "reaction_10555403", "reactome": "R-CEL-5679255", "name": "WIPI2 binds ATG12:ATG5:ATG16L", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10555375", "species_10555373" ], "products": [ "species_10555377" ], "modifiers": [], "additional_components": [ "O16466", "WBGene00018294", "species_5334668", "Q19124", "WBGene00017178", "Q09406", "WBGene00019427", "Q10931", "WBGene00002982", "Q3V5I7", "WBGene00022152", "Q19124", "WBGene00017178", "Q09406", "WBGene00019427", "Q10931", "WBGene00002982", "Q3V5I7", "WBGene00022152", "O16466", "WBGene00018294", "species_5334668" ] }, "reaction_10555405": { "compartment": "compartment_70101", "id": "reaction_10555405", "reactome": "R-CEL-5679266", "name": "Beclin-1 complex translocates to the ER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10536600" ], "products": [ "species_10555394" ], "modifiers": [], "additional_components": [ "Q9XWQ4", "WBGene00013695", "Q9TXI7", "WBGene00006932", "Q22592", "WBGene00000247", "Q23669", "WBGene00014151", "Q9TXI7", "WBGene00006932", "Q22592", "WBGene00000247", "Q23669", "WBGene00014151", "Q9XWQ4", "WBGene00013695" ] }, "reaction_10555469": { "compartment": "compartment_12045", "id": "reaction_10555469", "reactome": "R-CEL-5682385", "name": "The phagophore extends from the PIP3-enriched structure", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10554880" ], "products": [ "species_10555460" ], "modifiers": [ [ "species_10555465", "catalyst" ] ], "additional_components": [ "Q9TXI7", "WBGene00006932", "Q23669", "WBGene00014151", "Q9XWQ4", "WBGene00013695", "Q22592", "WBGene00000247", "Q9XWQ4", "WBGene00013695", "Q9TXI7", "WBGene00006932", "Q23669", "WBGene00014151", "Q22592", "WBGene00000247", "WBGene00020706" ] }, "reaction_10555598": { "compartment": "compartment_70101", "id": "reaction_10555598", "reactome": "R-CEL-5683925", "name": "ULK1 is dephosphorylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10554866" ], "products": [ "species_29372", "species_10554659" ], "modifiers": [], "additional_components": [ "Q22342", "WBGene00020334", "Q23023", "WBGene00006786", "Q95XH2", "WBGene00022078", "P34379", "WBGene00017045", "Q22342", "WBGene00020334", "Q23023", "WBGene00006786", "Q95XH2", "WBGene00022078", "P34379", "WBGene00017045" ] }, "reaction_10555537": { "compartment": "compartment_70101", "id": "reaction_10555537", "reactome": "R-CEL-5682896", "name": "LC3:ATG7 dimer binds ATG3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10555418", "species_10555352" ], "products": [ "species_10555420" ], "modifiers": [], "additional_components": [ "G5EBK4", "WBGene00010882", "Q23536", "WBGene00002981", "Q09490", "WBGene00002980", "WBGene00021922", "Q9N369", "WBGene00021922", "G5EBK4", "WBGene00010882", "Q23536", "WBGene00002981", "Q09490", "WBGene00002980" ] }, "reaction_10555411": { "compartment": "compartment_70101", "id": "reaction_10555411", "reactome": "R-CEL-5681980", "name": "ATG12 binds ATG7 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10555407", "species_10555366" ], "products": [ "species_10555409" ], "modifiers": [], "additional_components": [ "G5EBK4", "WBGene00010882", "WBGene00002982", "Q10931", "WBGene00002982", "G5EBK4", "WBGene00010882" ] }, "reaction_10555093": { "compartment": "compartment_70101", "id": "reaction_10555093", "reactome": "R-CEL-5673768", "name": "p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10554868" ], "products": [ "species_29370", "species_10555091" ], "modifiers": [ [ "species_10519954", "catalyst" ] ], "additional_components": [ "Q22342", "WBGene00020334", "Q23023", "WBGene00006786", "Q95XH2", "WBGene00022078", "P34379", "WBGene00017045", "Q19425", "WBGene00008774", "species_29420", "G5EGB3", "WBGene00012497", "Q22743", "WBGene00006414", "species_29438", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "P91040", "WBGene00015697", "Q95Q95", "WBGene00002583", "Q68TI8", "WBGene00000911", "P34443", "WBGene00010038", "Q22342", "WBGene00020334", "Q23023", "WBGene00006786", "Q95XH2", "WBGene00022078", "P34379", "WBGene00017045", "P34443", "WBGene00010038", "species_29438", "Q19425", "WBGene00008774", "species_29420", "G5EGB3", "WBGene00012497", "Q22743", "WBGene00006414", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "P91040", "WBGene00015697", "Q95Q95", "WBGene00002583", "Q68TI8", "WBGene00000911", "species_76577", "Q9XUY2", "WBGene00010115", "P45894", "WBGene00019801", "Q95ZQ4", "WBGene00020142", "A0A1T5HUK9", "WBGene00013732", "H2L0K0", "WBGene00020135", "O02168", "WBGene00020633", "Q9N501", "WBGene00021527" ] }, "reaction_10555284": { "compartment": "compartment_70101", "id": "reaction_10555284", "reactome": "R-CEL-5676229", "name": "WIPIs bind PI3P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5693050", "species_10555280" ], "products": [ "species_10555282" ], "modifiers": [], "additional_components": [ "O16466", "WBGene00018294", "O16466", "WBGene00018294", "species_1806200" ] }, "reaction_10563248": { "compartment": "compartment_6791047", "id": "reaction_10563248", "reactome": "R-CEL-6807872", "name": "Active ARF recruits coatomer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10563199", "species_10563244" ], "products": [ "species_10563246" ], "modifiers": [], "additional_components": [ "G5EGG0", "WBGene00010713", "Q9UAQ6", "WBGene00004266", "species_29438", "G5EGS5", "WBGene00007703", "Q94231", "WBGene00000190", "Q09236", "WBGene00015734", "Q22498", "WBGene00011775", "Q9TYL9", "WBGene00021292", "O17901", "WBGene00010333", "Q20168", "WBGene00009542", "O62246", "WBGene00009732", "Q9N4H7", "WBGene00022119", "Q09236", "WBGene00015734", "Q22498", "WBGene00011775", "Q9TYL9", "WBGene00021292", "O17901", "WBGene00010333", "Q20168", "WBGene00009542", "O62246", "WBGene00009732", "Q9N4H7", "WBGene00022119", "G5EGG0", "WBGene00010713", "Q9UAQ6", "WBGene00004266", "species_29438", "G5EGS5", "WBGene00007703", "Q94231", "WBGene00000190" ] }, "reaction_10563616": { "compartment": "compartment_20699", "id": "reaction_10563616", "reactome": "R-CEL-6809011", "name": "cis-Golgi t-SNAREs bind YKT6 on tethered vesicle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10563612", "species_10563597" ], "products": [ "species_10563614" ], "modifiers": [], "additional_components": [ "Q95ZW1", "WBGene00017273", "P41941", "WBGene00007128", "Q20797", "WBGene00006373", "G5EEU1", "WBGene00043064", "Q9N3Y1", "WBGene00021536", "Q19989", "WBGene00018017", "Q9TXZ9", "WBGene00015164", "Q18849", "WBGene00009500", "Q22328", "WBGene00002976", "A0A1N7SYP5", "WBGene00009500", "P48583", "WBGene00001331", "Q09473", "WBGene00016195", "G5EEU1", "WBGene00043064", "G5EGG0", "WBGene00010713", "Q9UAQ6", "WBGene00004266", "species_29438", "Q9N4H7", "WBGene00022119", "Q20168", "WBGene00009542", "O62246", "WBGene00009732", "Q22498", "WBGene00011775", "O17901", "WBGene00010333", "Q09236", "WBGene00015734", "Q9TYL9", "WBGene00021292", "O44738", "WBGene00019003", "Q20546", "WBGene00009829", "A4F319", "WBGene00011606", "Q9U1Z4", "WBGene00013360", "O17528", "WBGene00004766", "E0AHA7", "WBGene00006803", "G5EFW3", "WBGene00004855", "Q21408", "WBGene00004951", "Q21270", "WBGene00019481", "Q6AW08", "WBGene00022121", "Q95XZ0", "WBGene00021784", "G5EE66", "WBGene00003258", "O44502", "WBGene00019820", "Q21444", "WBGene00000585", "P91151", "WBGene00016608", "Q9U3K1", "WBGene00008687", "Q9N3Y1", "WBGene00021536", "Q19989", "WBGene00018017", "Q9TXZ9", "WBGene00015164", "Q18849", "WBGene00009500", "Q22328", "WBGene00002976", "A0A1N7SYP5", "WBGene00009500", "P48583", "WBGene00001331", "Q09473", "WBGene00016195", "G5EEU1", "WBGene00043064", "G5EGG0", "WBGene00010713", "Q9UAQ6", "WBGene00004266", "species_29438", "Q9N4H7", "WBGene00022119", "Q20168", "WBGene00009542", "O62246", "WBGene00009732", "Q22498", "WBGene00011775", "O17901", "WBGene00010333", "Q09236", "WBGene00015734", "Q9TYL9", "WBGene00021292", "O44738", "WBGene00019003", "Q20546", "WBGene00009829", "A4F319", "WBGene00011606", "Q9U1Z4", "WBGene00013360", "O17528", "WBGene00004766", "E0AHA7", "WBGene00006803", "G5EFW3", "WBGene00004855", "Q21408", "WBGene00004951", "Q21270", "WBGene00019481", "Q6AW08", "WBGene00022121", "Q95XZ0", "WBGene00021784", "G5EE66", "WBGene00003258", "O44502", "WBGene00019820", "Q21444", "WBGene00000585", "P91151", "WBGene00016608", "Q9U3K1", "WBGene00008687", "Q95ZW1", "WBGene00017273", "P41941", "WBGene00007128", "Q20797", "WBGene00006373" ] }, "reaction_10563202": { "compartment": "compartment_6791047", "id": "reaction_10563202", "reactome": "R-CEL-6807868", "name": "GBF1 stimulates ARF nucleotide exchange", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10563193" ], "products": [ "species_10563199", "species_29370" ], "modifiers": [ [ "species_10563193", "catalyst" ] ], "additional_components": [ "Q94231", "WBGene00000190", "species_29420", "G5EGG0", "WBGene00010713", "Q9UAQ6", "WBGene00004266", "species_29438", "G5EGS5", "WBGene00007703", "G5EGG0", "WBGene00010713", "Q9UAQ6", "WBGene00004266", "species_29438", "G5EGS5", "WBGene00007703", "Q94231", "WBGene00000190", "Q94231", "WBGene00000190", "species_29420", "G5EGG0", "WBGene00010713", "Q9UAQ6", "WBGene00004266", "species_29438", "G5EGS5", "WBGene00007703" ] }, "reaction_10563622": { "compartment": "compartment_20699", "id": "reaction_10563622", "reactome": "R-CEL-6809014", "name": "cis-Golgi cis-SNARE binds NSF and SNAPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10563618", "species_10557345", "species_10557329" ], "products": [ "species_10563620" ], "modifiers": [], "additional_components": [ "Q9TXZ9", "WBGene00015164", "Q95ZW1", "WBGene00017273", "P41941", "WBGene00007128", "Q20797", "WBGene00006373", "G5EEU1", "WBGene00043064", "Q18921", "WBGene00017016", "Q94392", "WBGene00003818", "Q18921", "WBGene00017016", "Q94392", "WBGene00003818", "Q9TXZ9", "WBGene00015164", "Q95ZW1", "WBGene00017273", "P41941", "WBGene00007128", "Q20797", "WBGene00006373", "G5EEU1", "WBGene00043064" ] }, "reaction_10563195": { "compartment": "compartment_6791047", "id": "reaction_10563195", "reactome": "R-CEL-6807866", "name": "GBF1 recruits ARF:GDP to the ERGIC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10563181", "species_10563191" ], "products": [ "species_10563193" ], "modifiers": [], "additional_components": [ "G5EGG0", "WBGene00010713", "Q9UAQ6", "WBGene00004266", "species_29438", "G5EGS5", "WBGene00007703", "Q94231", "WBGene00000190", "species_29420", "Q94231", "WBGene00000190", "species_29420", "G5EGG0", "WBGene00010713", "Q9UAQ6", "WBGene00004266", "species_29438", "G5EGS5", "WBGene00007703" ] }, "reaction_10563419": { "compartment": "compartment_6791047", "id": "reaction_10563419", "reactome": "R-CEL-6807877", "name": "ARFGAPs stimulate ARF GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10563328" ], "products": [ "species_10563262", "species_10563179", "species_10563416", "species_10563191" ], "modifiers": [ [ "species_10563328", "catalyst" ] ], "additional_components": [ "Q9TXZ9", "WBGene00015164", "Q20546", "WBGene00009829", "O17528", "WBGene00004766", "A4F319", "WBGene00011606", "Q9U1Z4", "WBGene00013360", "O44738", "WBGene00019003", "Q22328", "WBGene00002976", "A0A1N7SYP5", "WBGene00009500", "Q18849", "WBGene00009500", "P48583", "WBGene00001331", "Q09473", "WBGene00016195", "G5EEU1", "WBGene00043064", "E0AHA7", "WBGene00006803", "G5EFW3", "WBGene00004855", "Q21408", "WBGene00004951", "Q09236", "WBGene00015734", "Q22498", "WBGene00011775", "Q9TYL9", "WBGene00021292", "O17901", "WBGene00010333", "Q20168", "WBGene00009542", "O62246", "WBGene00009732", "Q9N4H7", "WBGene00022119", "G5EGG0", "WBGene00010713", "Q9UAQ6", "WBGene00004266", "species_29438", "G5EGS5", "WBGene00007703", "Q94231", "WBGene00000190", "Q09531", "WBGene00017217", "P90904", "WBGene00010500", "Q09531", "WBGene00017217", "P90904", "WBGene00010500", "WBGene00007703", "Q9UAQ6", "WBGene00004266", "species_29438", "G5EGG0", "WBGene00010713", "Q09236", "WBGene00015734", "Q9TYL9", "WBGene00021292", "Q22498", "WBGene00011775", "O17901", "WBGene00010333", "Q9N4H7", "WBGene00022119", "Q20168", "WBGene00009542", "O62246", "WBGene00009732", "Q20546", "WBGene00009829", "Q9U1Z4", "WBGene00013360", "A4F319", "WBGene00011606", "O17528", "WBGene00004766", "O44738", "WBGene00019003", "P48583", "WBGene00001331", "Q09473", "WBGene00016195", "A0A1N7SYP5", "WBGene00009500", "Q18849", "WBGene00009500", "Q22328", "WBGene00002976", "G5EEU1", "WBGene00043064", "Q9TXZ9", "WBGene00015164", "E0AHA7", "WBGene00006803", "G5EFW3", "WBGene00004855", "Q21408", "WBGene00004951", "Q94231", "WBGene00000190", "species_29420", "Q9TXZ9", "WBGene00015164", "Q20546", "WBGene00009829", "O17528", "WBGene00004766", "A4F319", "WBGene00011606", "Q9U1Z4", "WBGene00013360", "O44738", "WBGene00019003", "Q22328", "WBGene00002976", "A0A1N7SYP5", "WBGene00009500", "Q18849", "WBGene00009500", "P48583", "WBGene00001331", "Q09473", "WBGene00016195", "G5EEU1", "WBGene00043064", "E0AHA7", "WBGene00006803", "G5EFW3", "WBGene00004855", "Q21408", "WBGene00004951", "Q09236", "WBGene00015734", "Q22498", "WBGene00011775", "Q9TYL9", "WBGene00021292", "O17901", "WBGene00010333", "Q20168", "WBGene00009542", "O62246", "WBGene00009732", "Q9N4H7", "WBGene00022119", "G5EGG0", "WBGene00010713", "Q9UAQ6", "WBGene00004266", "species_29438", "G5EGS5", "WBGene00007703", "Q94231", "WBGene00000190", "Q09531", "WBGene00017217", "P90904", "WBGene00010500" ] }, "reaction_10563453": { "compartment": "compartment_432051", "id": "reaction_10563453", "reactome": "R-CEL-6809003", "name": "ERGIC-to-Golgi vesicles bind dynein:dynactin ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10563416", "species_10553033" ], "products": [ "species_10563451" ], "modifiers": [], "additional_components": [ "Q9UAQ6", "WBGene00004266", "species_29438", "G5EGG0", "WBGene00010713", "Q09236", "WBGene00015734", "Q9TYL9", "WBGene00021292", "Q22498", "WBGene00011775", "O17901", "WBGene00010333", "Q9N4H7", "WBGene00022119", "Q20168", "WBGene00009542", "O62246", "WBGene00009732", "Q20546", "WBGene00009829", "Q9U1Z4", "WBGene00013360", "A4F319", "WBGene00011606", "O17528", "WBGene00004766", "O44738", "WBGene00019003", "P48583", "WBGene00001331", "Q09473", "WBGene00016195", "A0A1N7SYP5", "WBGene00009500", "Q18849", "WBGene00009500", "Q22328", "WBGene00002976", "G5EEU1", "WBGene00043064", "Q9TXZ9", "WBGene00015164", "E0AHA7", "WBGene00006803", "G5EFW3", "WBGene00004855", "Q21408", "WBGene00004951", "Q19020", "WBGene00000962", "O45087", "WBGene00015927", "Q65XS9", "WBGene00043067", "A0AAC1", "WBGene00012424", "Q7YTJ8", "WBGene00012425", "Q21557", "WBGene00010888", "Q22799", "WBGene00001005", "G5ED34", "WBGene00001007", "species_29420", "species_29438", "Q9NA98", "WBGene00013168", "P34685", "WBGene00000292", "P34686", "WBGene00000293", "Q18194", "WBGene00016124", "Q9N4I1", "WBGene00022118", "Q9N3F1", "WBGene00021827", "Q9GYR2", "WBGene00016793", "Q09248", "WBGene00001018", "E2JKZ0", "WBGene00001017", "Q19020", "WBGene00000962", "O45087", "WBGene00015927", "Q65XS9", "WBGene00043067", "A0AAC1", "WBGene00012424", "Q7YTJ8", "WBGene00012425", "Q21557", "WBGene00010888", "Q22799", "WBGene00001005", "G5ED34", "WBGene00001007", "species_29420", "species_29438", "Q9NA98", "WBGene00013168", "P34685", "WBGene00000292", "P34686", "WBGene00000293", "Q18194", "WBGene00016124", "Q9N4I1", "WBGene00022118", "Q9N3F1", "WBGene00021827", "Q9GYR2", "WBGene00016793", "Q09248", "WBGene00001018", "E2JKZ0", "WBGene00001017", "Q9UAQ6", "WBGene00004266", "G5EGG0", "WBGene00010713", "Q09236", "WBGene00015734", "Q9TYL9", "WBGene00021292", "Q22498", "WBGene00011775", "O17901", "WBGene00010333", "Q9N4H7", "WBGene00022119", "Q20168", "WBGene00009542", "O62246", "WBGene00009732", "Q20546", "WBGene00009829", "Q9U1Z4", "WBGene00013360", "A4F319", "WBGene00011606", "O17528", "WBGene00004766", "O44738", "WBGene00019003", "P48583", "WBGene00001331", "Q09473", "WBGene00016195", "A0A1N7SYP5", "WBGene00009500", "Q18849", "WBGene00009500", "Q22328", "WBGene00002976", "G5EEU1", "WBGene00043064", "Q9TXZ9", "WBGene00015164", "E0AHA7", "WBGene00006803", "G5EFW3", "WBGene00004855", "Q21408", "WBGene00004951" ] }, "reaction_10563183": { "compartment": "compartment_6791047", "id": "reaction_10563183", "reactome": "R-CEL-6807864", "name": "RAB1:GTP recruits GBF1 to the ERGIC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10563179", "species_10563177", "species_10557302" ], "products": [ "species_10563181" ], "modifiers": [], "additional_components": [ "WBGene00007703", "Q9UAQ6", "WBGene00004266", "species_29438", "G5EGG0", "WBGene00010713", "G5EGG0", "WBGene00010713", "Q9UAQ6", "WBGene00004266", "species_29438", "G5EGS5", "WBGene00007703" ] }, "reaction_10524156": { "compartment": "compartment_17906", "id": "reaction_10524156", "reactome": "R-CEL-434382", "name": "ACSL3,4 ligates coenzyme A (CoA-SH) to palmitate yielding palmitoyl-coenzyme A in the pancreatic beta cell", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_3632881", "species_76194" ], "products": [ "species_1132084", "species_200993", "species_76577" ], "modifiers": [ [ "species_10524153", "catalyst" ] ], "additional_components": [ "A0A4V0ING4", "WBGene00016716", "Q20121", "WBGene00018152" ] }, "reaction_10559061": { "compartment": "compartment_7660", "id": "reaction_10559061", "reactome": "R-CEL-6791227", "name": "47S pre-rRNA is nucleolytically processed at A' (01,A1), site A0, and site 02 (site 6) to yield 45S pre-rRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10559047" ], "products": [ "species_10559051" ], "modifiers": [ [ "species_10559056", "catalyst" ], [ "species_10558582", "catalyst" ], [ "species_10559059", "catalyst" ], [ "species_10558737", "catalyst" ], [ "species_10558715", "catalyst" ], [ "species_10558761", "catalyst" ] ], "additional_components": [ "Q9XX15", "WBGene00012652", "Q22053", "WBGene00001423", "Q21568", "WBGene00010896", "O45012", "WBGene00020915", "Q21276", "WBGene00010627", "A9D0C6", "WBGene00020171", "O16311", "WBGene00015461", "Q95XY4", "WBGene00021789", "Q8MNX1", "WBGene00020705", "Q23314", "WBGene00013892", "Q21736", "WBGene00011032", "P34580", "WBGene00012059", "Q9N3Q9", "WBGene00021660", "Q22046", "WBGene00011311", "Q18038", "WBGene00002850", "Q23494", "WBGene00022742", "Q19873", "WBGene00009211", "A7DT40", "WBGene00045433", "Q9N477", "WBGene00021276", "Q9XUU8", "WBGene00010582", "Q23495", "WBGene00022739", "P51403", "WBGene00004471", "Q09462", "WBGene00007623", "Q9NEN6", "WBGene00004475", "Q9N306", "WBGene00022021", "Q23400", "WBGene00022852", "Q23312", "WBGene00004476", "Q20228", "WBGene00004478", "P48150", "WBGene00004483", "P41843", "WBGene00020601", "Q19545", "WBGene00007050", "Q93638", "WBGene00009266", "P91280", "WBGene00017855", "Q9U2I4", "WBGene00012756", "O01513", "WBGene00016740", "O62518", "WBGene00014083", "Q9XW58", "WBGene00013544", "Q2WF63", "WBGene00019219", "P42000", "WBGene00015104", "P91341", "WBGene00018891", "Q19433", "WBGene00017435", "O62477", "WBGene00012887", "O18215", "WBGene00013143", "P34305", "WBGene00015525", "Q9XX15", "WBGene00012652", "Q22053", "WBGene00001423", "Q21568", "WBGene00010896", "O45012", "WBGene00020915", "Q21276", "WBGene00010627", "A9D0C6", "WBGene00020171", "O16311", "WBGene00015461", "Q95XY4", "WBGene00021789", "Q8MNX1", "WBGene00020705", "Q23314", "WBGene00013892", "Q21736", "WBGene00011032", "P34580", "WBGene00012059", "Q9N3Q9", "WBGene00021660", "Q22046", "WBGene00011311", "Q18038", "WBGene00002850", "Q23494", "WBGene00022742", "Q19873", "WBGene00009211", "A7DT40", "WBGene00045433", "Q9N477", "WBGene00021276", "Q9XUU8", "WBGene00010582", "Q23495", "WBGene00022739", "P51403", "WBGene00004471", "Q09462", "WBGene00007623", "Q9NEN6", "WBGene00004475", "Q9N306", "WBGene00022021", "Q23400", "WBGene00022852", "Q23312", "WBGene00004476", "Q20228", "WBGene00004478", "P48150", "WBGene00004483", "P41843", "WBGene00020601", "Q19545", "WBGene00007050", "Q93638", "WBGene00009266", "P91280", "WBGene00017855", "Q9U2I4", "WBGene00012756", "O01513", "WBGene00016740", "O62518", "WBGene00014083", "Q9XW58", "WBGene00013544", "Q2WF63", "WBGene00019219", "P42000", "WBGene00015104", "P91341", "WBGene00018891", "Q19433", "WBGene00017435", "O62477", "WBGene00012887", "O18215", "WBGene00013143", "P34305", "WBGene00015525", "WBGene00006964", "WBGene00012342", "WBGene00004705", "WBGene00015104", "A7DT40", "WBGene00045433", "Q9N477", "WBGene00021276", "Q9XUU8", "WBGene00010582", "Q23495", "WBGene00022739", "Q95XY4", "WBGene00021789", "Q8MNX1", "WBGene00020705", "Q23314", "WBGene00013892" ] }, "reaction_10558907": { "compartment": "compartment_7660", "id": "reaction_10558907", "reactome": "R-CEL-6791222", "name": "21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10558872" ], "products": [ "species_10558880" ], "modifiers": [ [ "species_10558904", "catalyst" ], [ "species_10558594", "catalyst" ], [ "species_10558892", "catalyst" ], [ "species_10558582", "catalyst" ] ], "additional_components": [ "Q9XX15", "WBGene00012652", "Q22053", "WBGene00001423", "Q21568", "WBGene00010896", "O45012", "WBGene00020915", "Q21276", "WBGene00010627", "A9D0C6", "WBGene00020171", "O16311", "WBGene00015461", "Q95XY4", "WBGene00021789", "Q8MNX1", "WBGene00020705", "Q23314", "WBGene00013892", "Q21736", "WBGene00011032", "P34580", "WBGene00012059", "Q9N3Q9", "WBGene00021660", "Q22046", "WBGene00011311", "Q18038", "WBGene00002850", "Q23494", "WBGene00022742", "Q19873", "WBGene00009211", "A7DT40", "WBGene00045433", "Q9N477", "WBGene00021276", "Q9XUU8", "WBGene00010582", "Q23495", "WBGene00022739", "P51403", "WBGene00004471", "Q09462", "WBGene00007623", "Q9NEN6", "WBGene00004475", "Q9N306", "WBGene00022021", "Q23400", "WBGene00022852", "Q23312", "WBGene00004476", "Q20228", "WBGene00004478", "P48150", "WBGene00004483", "P41843", "WBGene00020601", "Q19545", "WBGene00007050", "Q93638", "WBGene00009266", "P91280", "WBGene00017855", "Q9U2I4", "WBGene00012756", "O01513", "WBGene00016740", "O62518", "WBGene00014083", "Q9XW58", "WBGene00013544", "Q2WF63", "WBGene00019219", "P42000", "WBGene00015104", "P91341", "WBGene00018891", "Q19433", "WBGene00017435", "O62477", "WBGene00012887", "O18215", "WBGene00013143", "P34305", "WBGene00015525", "Q9XX15", "WBGene00012652", "Q22053", "WBGene00001423", "Q21568", "WBGene00010896", "O45012", "WBGene00020915", "Q21276", "WBGene00010627", "A9D0C6", "WBGene00020171", "O16311", "WBGene00015461", "Q95XY4", "WBGene00021789", "Q8MNX1", "WBGene00020705", "Q23314", "WBGene00013892", "Q21736", "WBGene00011032", "P34580", "WBGene00012059", "Q9N3Q9", "WBGene00021660", "Q22046", "WBGene00011311", "Q18038", "WBGene00002850", "Q23494", "WBGene00022742", "Q19873", "WBGene00009211", "A7DT40", "WBGene00045433", "Q9N477", "WBGene00021276", "Q9XUU8", "WBGene00010582", "Q23495", "WBGene00022739", "P51403", "WBGene00004471", "Q09462", "WBGene00007623", "Q9NEN6", "WBGene00004475", "Q9N306", "WBGene00022021", "Q23400", "WBGene00022852", "Q23312", "WBGene00004476", "Q20228", "WBGene00004478", "P48150", "WBGene00004483", "P41843", "WBGene00020601", "Q19545", "WBGene00007050", "Q93638", "WBGene00009266", "P91280", "WBGene00017855", "Q9U2I4", "WBGene00012756", "O01513", "WBGene00016740", "O62518", "WBGene00014083", "Q9XW58", "WBGene00013544", "Q2WF63", "WBGene00019219", "P42000", "WBGene00015104", "P91341", "WBGene00018891", "Q19433", "WBGene00017435", "O62477", "WBGene00012887", "O18215", "WBGene00013143", "P34305", "WBGene00015525", "Q9N3J4", "WBGene00021785", "G5EBX6", "WBGene00000796", "O16207", "WBGene00017916", "G5EDS8", "WBGene00009289", "Q95QG7", "WBGene00018305", "Q9XXD2", "WBGene00012966", "Q20128", "WBGene00018154", "Q95XD0", "WBGene00022232", "Q93830", "WBGene00010325", "Q17533", "WBGene00007201", "G5EG59", "WBGene00000798", "Q9N4P9", "WBGene00000202", "Q23223", "WBGene00012342", "WBGene00000796", "WBGene00000798", "WBGene00012342" ] }, "reaction_10558639": { "compartment": "compartment_7660", "id": "reaction_10558639", "reactome": "R-CEL-6791219", "name": "32S pre-rRNA is nucleolytically processed at site 4 (4a) to yield 12S pre-rRNA and 28S rRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10558620" ], "products": [ "species_10558572" ], "modifiers": [ [ "species_10558557", "catalyst" ], [ "species_10558562", "catalyst" ], [ "species_10558637", "catalyst" ], [ "species_10558618", "catalyst" ] ], "additional_components": [ "Q9U3B6", "WBGene00010709", "Q22006", "WBGene00004185", "Q9XWK5", "WBGene00012977", "O44984", "WBGene00006740", "Q09353", "WBGene00006736", "Q23238", "WBGene00006737", "Q95Y89", "WBGene00003063", "P91343", "WBGene00018893", "Q9U2A9", "WBGene00012978", "Q9U1T1", "WBGene00012393", "Q9U3B6", "WBGene00010709", "Q22006", "WBGene00004185", "Q9XWK5", "WBGene00012977", "O44984", "WBGene00006740", "Q09353", "WBGene00006736", "Q23238", "WBGene00006737", "Q9U1T1", "WBGene00012393", "WBGene00012393", "WBGene00010709", "Q17978", "WBGene00003507", "Q95Y89", "WBGene00003063", "Q09958", "WBGene00015941", "Q21086", "WBGene00003821", "Q95Y89", "WBGene00003063", "P91343", "WBGene00018893", "Q9U2A9", "WBGene00012978" ] }, "reaction_10570551": { "compartment": "compartment_70101", "id": "reaction_10570551", "reactome": "R-CEL-8983379", "name": "p-Y-STAT3:p-STAT5 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10570523" ], "products": [ "species_10570549" ], "modifiers": [], "additional_components": [ "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251" ] }, "reaction_10570525": { "compartment": "compartment_70101", "id": "reaction_10570525", "reactome": "R-CEL-8983373", "name": "p-Y-STAT3 binds p-STAT5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10570521", "species_10570515" ], "products": [ "species_10570523" ], "modifiers": [], "additional_components": [ "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111" ] }, "reaction_10533095": { "compartment": "compartment_7660", "id": "reaction_10533095", "reactome": "R-CEL-1363328", "name": "Phosphorylated p130 (RBL2) binds SCF(Skp2):Cks1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10532102", "species_10512514" ], "products": [ "species_10533093" ], "modifiers": [], "additional_components": [ "WBGene00003020", "G5ECU1", "WBGene00004807", "Q17389", "WBGene00000836", "Q17868", "WBGene00001051", "G5ECU1", "WBGene00004807", "Q17389", "WBGene00000836", "Q17868", "WBGene00001051", "G5EDT1", "WBGene00003020" ] }, "reaction_10533100": { "compartment": "compartment_7660", "id": "reaction_10533100", "reactome": "R-CEL-1363331", "name": "Ubiquitination of p130 (RBL2) by SCF (Skp2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502318", "species_10533093" ], "products": [ "species_10533097", "species_10512514" ], "modifiers": [ [ "species_10533093", "catalyst" ] ], "additional_components": [ "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "G5ECU1", "WBGene00004807", "Q17389", "WBGene00000836", "Q17868", "WBGene00001051", "G5EDT1", "WBGene00003020", "G5EDT1", "WBGene00003020", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "G5ECU1", "WBGene00004807", "Q17389", "WBGene00000836", "Q17868", "WBGene00001051", "G5ECU1", "WBGene00004807", "Q17389", "WBGene00000836", "Q17868", "WBGene00001051", "G5EDT1", "WBGene00003020" ] }, "reaction_10533069": { "compartment": "compartment_7660", "id": "reaction_10533069", "reactome": "R-CEL-1363274", "name": "Dephosphorylation of p107 (RBL1) by PP2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10532114" ], "products": [ "species_113550", "species_10532106" ], "modifiers": [ [ "species_10533066", "catalyst" ] ], "additional_components": [ "WBGene00003020", "WBGene00003020" ] }, "reaction_10533071": { "compartment": "compartment_7660", "id": "reaction_10533071", "reactome": "R-CEL-1363276", "name": "Dephosphorylation of p130 (RBL2) by PP2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10532102" ], "products": [ "species_113550", "species_10532081" ], "modifiers": [ [ "species_10533066", "catalyst" ] ], "additional_components": [ "WBGene00003020", "WBGene00003020" ] }, "reaction_10531928": { "compartment": "compartment_12045", "id": "reaction_10531928", "reactome": "R-CEL-1168376", "name": "STIM1 oligomerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10531921" ], "products": [ "species_10531923", "species_74016" ], "modifiers": [ [ "species_10531925", "catalyst" ] ], "additional_components": [ "species_74016", "G5EF60", "WBGene00021910", "G5EF60", "WBGene00021910", "Q9Y0A1", "WBGene00002173", "species_114520" ] }, "reaction_10542490": { "compartment": "compartment_12045", "id": "reaction_10542490", "reactome": "R-CEL-2089927", "name": "STIM1 binds TRPC1 forming STIM1:TRPC1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10542486", "species_10531923" ], "products": [ "species_10542488" ], "modifiers": [], "additional_components": [ "WBGene00006615", "G5EF60", "WBGene00021910", "G5EF60", "WBGene00021910", "Q8I6Y9", "WBGene00006615" ] }, "reaction_10542493": { "compartment": "compartment_70101", "id": "reaction_10542493", "reactome": "R-CEL-2089943", "name": "TRPC1 translocates calcium from the extracellular region to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74112" ], "products": [ "species_74016" ], "modifiers": [ [ "species_10542488", "catalyst" ] ], "additional_components": [ "G5EF60", "WBGene00021910", "Q8I6Y9", "WBGene00006615" ] }, "reaction_10514689": { "compartment": "compartment_70101", "id": "reaction_10514689", "reactome": "R-CEL-200681", "name": "FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29404", "species_200665", "species_113592" ], "products": [ "species_29372", "species_29370", "species_174404" ], "modifiers": [ [ "species_10513791", "catalyst" ] ], "additional_components": [ "WBGene00017777" ] }, "reaction_10513794": { "compartment": "compartment_70101", "id": "reaction_10513794", "reactome": "R-CEL-197958", "name": "FPGS-2 transforms THF to THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29404", "species_111355", "species_113592" ], "products": [ "species_29372", "species_29370", "species_197969" ], "modifiers": [ [ "species_10513791", "catalyst" ] ], "additional_components": [ "WBGene00017777" ] }, "reaction_10562914": { "compartment": "compartment_70101", "id": "reaction_10562914", "reactome": "R-CEL-6801342", "name": "MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6803257", "species_113592" ], "products": [ "species_29372", "species_70106", "species_29370", "species_200640" ], "modifiers": [ [ "species_10562911", "catalyst" ] ], "additional_components": [ "WBGene00013708" ] }, "reaction_10514628": { "compartment": "compartment_70101", "id": "reaction_10514628", "reactome": "R-CEL-200644", "name": "5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29366", "species_200739" ], "products": [ "species_70106", "species_29364", "species_200640" ], "modifiers": [ [ "species_10514625", "catalyst" ] ], "additional_components": [ "Q21285", "WBGene00000929" ] }, "reaction_10562916": { "compartment": "compartment_5460", "id": "reaction_10562916", "reactome": "R-CEL-6801456", "name": "MTHFD1L transforms 10-formyl-THF to HCOOH and THF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113548", "species_113581", "species_5389850" ], "products": [ "species_200671", "species_6801451", "species_113593" ], "modifiers": [ [ "species_10557703", "catalyst" ] ], "additional_components": [ "Q21285", "WBGene00000929" ] }, "reaction_10514694": { "compartment": "compartment_5460", "id": "reaction_10514694", "reactome": "R-CEL-200682", "name": "Mitochondrial FPGS-1 transforms THF to THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200671", "species_113593", "species_113552" ], "products": [ "species_113548", "species_113581", "species_200679" ], "modifiers": [ [ "species_10514691", "catalyst" ] ], "additional_components": [ "WBGene00017777" ] }, "reaction_10514697": { "compartment": "compartment_70101", "id": "reaction_10514697", "reactome": "R-CEL-200711", "name": "MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_29460", "species_197969" ], "products": [ "species_29372", "species_29370", "species_111353" ], "modifiers": [ [ "species_10514625", "catalyst" ] ], "additional_components": [ "Q21285", "WBGene00000929" ] }, "reaction_10514666": { "compartment": "compartment_876", "id": "reaction_10514666", "reactome": "R-CEL-200652", "name": "SLC19A1 transports 5-methyl-THF from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200709" ], "products": [ "species_200665" ], "modifiers": [ [ "species_10514663", "catalyst" ] ], "additional_components": [ "O45166", "WBGene00018138", "Q17766", "WBGene00007388", "Q22931", "WBGene00044738" ] }, "reaction_10513802": { "compartment": "compartment_70101", "id": "reaction_10513802", "reactome": "R-CEL-197963", "name": "DHFR2 reduces FOLA to DHF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_197965", "species_70106", "species_29364" ], "products": [ "species_29366", "species_73604" ], "modifiers": [ [ "species_10513799", "catalyst" ] ], "additional_components": [ "WBGene00007974" ] }, "reaction_10557706": { "compartment": "compartment_5460", "id": "reaction_10557706", "reactome": "R-CEL-5696839", "name": "MTHFD1L dimer ligates HCOOH to THF to form 10-formyl-THF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6801451", "species_200671", "species_113593" ], "products": [ "species_113548", "species_113581", "species_5389850" ], "modifiers": [ [ "species_10557703", "catalyst" ] ], "additional_components": [ "Q21285", "WBGene00000929" ] }, "reaction_10514699": { "compartment": "compartment_70101", "id": "reaction_10514699", "reactome": "R-CEL-200718", "name": "MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_200640" ], "products": [ "species_29366", "species_200739" ], "modifiers": [ [ "species_10514625", "catalyst" ] ], "additional_components": [ "Q21285", "WBGene00000929" ] }, "reaction_10513804": { "compartment": "compartment_70101", "id": "reaction_10513804", "reactome": "R-CEL-197972", "name": "DHF is reduced to tetrahydrofolate (THF)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_73604", "species_29364" ], "products": [ "species_111355", "species_29366" ], "modifiers": [ [ "species_10513799", "catalyst" ] ], "additional_components": [ "WBGene00007974" ] }, "reaction_10514701": { "compartment": "compartment_70616", "id": "reaction_10514701", "reactome": "R-CEL-200720", "name": "SLC25A32 transports THF from mitochondrial matrix to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200671" ], "products": [ "species_111355" ], "modifiers": [ [ "species_10514684", "catalyst" ] ], "additional_components": [ "WBGene00010459" ] }, "reaction_10514669": { "compartment": "compartment_70101", "id": "reaction_10514669", "reactome": "R-CEL-200661", "name": "MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111353" ], "products": [ "species_29356", "species_200640" ], "modifiers": [ [ "species_10514625", "catalyst" ] ], "additional_components": [ "Q21285", "WBGene00000929" ] }, "reaction_10514703": { "compartment": "compartment_876", "id": "reaction_10514703", "reactome": "R-CEL-200729", "name": "SLC46A1 transports FOLA from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200716" ], "products": [ "species_197965" ], "modifiers": [ [ "species_10514650", "catalyst" ] ], "additional_components": [ "Q9UAZ6", "WBGene00021159", "Q9XWL3", "WBGene00012811", "H2KZC0", "WBGene00016705", "Q20236", "WBGene00009582" ] }, "reaction_10563441": { "compartment": "compartment_5460", "id": "reaction_10563441", "reactome": "R-CEL-6808487", "name": "ALDH1L2 dehydrogenates 10-formyl-THFPG to THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113563", "species_6808499", "species_113521" ], "products": [ "species_113529", "species_200679", "species_113600", "species_29376" ], "modifiers": [ [ "species_10563438", "catalyst" ] ], "additional_components": [ "G5ECV9", "WBGene00000109" ] }, "reaction_10514705": { "compartment": "compartment_70101", "id": "reaction_10514705", "reactome": "R-CEL-200735", "name": "SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200736", "species_197969" ], "products": [ "species_29424", "species_200739" ], "modifiers": [ [ "species_10503873", "catalyst" ] ], "additional_components": [ "P50432", "WBGene00003214" ] }, "reaction_10514707": { "compartment": "compartment_70101", "id": "reaction_10514707", "reactome": "R-CEL-200740", "name": "5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_200640" ], "products": [ "species_111353" ], "modifiers": [ [ "species_10514625", "catalyst" ] ], "additional_components": [ "Q21285", "WBGene00000929" ] }, "reaction_10573332": { "compartment": "compartment_70101", "id": "reaction_10573332", "reactome": "R-CEL-9709098", "name": "DHFR dimer reduces FOLA to DHF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_197965", "species_70106", "species_29364" ], "products": [ "species_29366", "species_73604" ], "modifiers": [ [ "species_10573329", "catalyst" ] ], "additional_components": [ "Q93341", "WBGene00007974" ] }, "reaction_10514679": { "compartment": "compartment_70101", "id": "reaction_10514679", "reactome": "R-CEL-200676", "name": "MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_200739" ], "products": [ "species_29366", "species_174404" ], "modifiers": [ [ "species_10514676", "catalyst" ] ], "additional_components": [ "Q17693", "WBGene00015512" ] }, "reaction_10563449": { "compartment": "compartment_70101", "id": "reaction_10563449", "reactome": "R-CEL-6808496", "name": "ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_111353", "species_29366" ], "products": [ "species_70106", "species_113528", "species_29364", "species_197969" ], "modifiers": [ [ "species_10563446", "catalyst" ] ], "additional_components": [ "G5ECV9", "WBGene00000109" ] }, "reaction_10514653": { "compartment": "compartment_876", "id": "reaction_10514653", "reactome": "R-CEL-200646", "name": "Cytosolic folate export across the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_197965" ], "products": [ "species_200716" ], "modifiers": [ [ "species_10514650", "catalyst" ] ], "additional_components": [ "Q9UAZ6", "WBGene00021159", "Q9XWL3", "WBGene00012811", "H2KZC0", "WBGene00016705", "Q20236", "WBGene00009582" ] }, "reaction_10514655": { "compartment": "compartment_70101", "id": "reaction_10514655", "reactome": "R-CEL-200651", "name": "5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29424", "species_200739" ], "products": [ "species_200736", "species_197969" ], "modifiers": [ [ "species_10503873", "catalyst" ] ], "additional_components": [ "P50432", "WBGene00003214" ] }, "reaction_10507440": { "compartment": "compartment_7660", "id": "reaction_10507440", "reactome": "R-CEL-75866", "name": "Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10507428" ], "products": [ "species_10507436" ], "modifiers": [], "additional_components": [ "G5EG49", "WBGene00013998", "G5EG47", "WBGene00010054", "O44625", "WBGene00004136", "Q9NEX2", "WBGene00013736", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "species_110614", "species_29358", "species_29494", "species_29438", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q95ZS0", "WBGene00006392", "Q9GZI6", "WBGene00006387", "G5EF68", "WBGene00006386", "O45784", "WBGene00006391", "P32085", "WBGene00006542", "O61707", "WBGene00006385", "Q9NEW8", "WBGene00006389", "Q9TYN3", "WBGene00006383", "Q18265", "WBGene00016173", "Q17957", "WBGene00006397", "E9P861", "WBGene00006384", "Q20361", "WBGene00006395", "G5EGM3", "WBGene00006382", "O16991", "WBGene00006648", "G5EG49", "WBGene00013998", "G5EG47", "WBGene00010054", "O44625", "WBGene00004136", "Q9NEX2", "WBGene00013736", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q95ZS0", "WBGene00006392", "Q9GZI6", "WBGene00006387", "G5EF68", "WBGene00006386", "O45784", "WBGene00006391", "P32085", "WBGene00006542", "O61707", "WBGene00006385", "Q9NEW8", "WBGene00006389", "Q9TYN3", "WBGene00006383", "Q18265", "WBGene00016173", "Q17957", "WBGene00006397", "E9P861", "WBGene00006384", "Q20361", "WBGene00006395", "G5EGM3", "WBGene00006382", "O16991", "WBGene00006648", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529" ] }, "reaction_10507430": { "compartment": "compartment_7660", "id": "reaction_10507430", "reactome": "R-CEL-75861", "name": "NTP Binds Active Site of RNA Polymerase II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30595", "species_10507424" ], "products": [ "species_10507428" ], "modifiers": [], "additional_components": [ "species_110614", "species_29358", "species_29494", "species_29438", "G5EG49", "WBGene00013998", "G5EG47", "WBGene00010054", "O44625", "WBGene00004136", "Q9NEX2", "WBGene00013736", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q95ZS0", "WBGene00006392", "Q9GZI6", "WBGene00006387", "G5EF68", "WBGene00006386", "O45784", "WBGene00006391", "P32085", "WBGene00006542", "O61707", "WBGene00006385", "Q9NEW8", "WBGene00006389", "Q9TYN3", "WBGene00006383", "Q18265", "WBGene00016173", "Q17957", "WBGene00006397", "E9P861", "WBGene00006384", "Q20361", "WBGene00006395", "G5EGM3", "WBGene00006382", "O16991", "WBGene00006648", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "G5EG49", "WBGene00013998", "G5EG47", "WBGene00010054", "O44625", "WBGene00004136", "Q9NEX2", "WBGene00013736", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "species_110614", "species_29358", "species_29494", "species_29438", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q95ZS0", "WBGene00006392", "Q9GZI6", "WBGene00006387", "G5EF68", "WBGene00006386", "O45784", "WBGene00006391", "P32085", "WBGene00006542", "O61707", "WBGene00006385", "Q9NEW8", "WBGene00006389", "Q9TYN3", "WBGene00006383", "Q18265", "WBGene00016173", "Q17957", "WBGene00006397", "E9P861", "WBGene00006384", "Q20361", "WBGene00006395", "G5EGM3", "WBGene00006382", "O16991", "WBGene00006648" ] }, "reaction_10507438": { "compartment": "compartment_7660", "id": "reaction_10507438", "reactome": "R-CEL-75864", "name": "Newly Formed Phosphodiester Bond Stabilized and PPi Released", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10507436" ], "products": [ "species_113541", "species_10506530" ], "modifiers": [], "additional_components": [ "G5EG49", "WBGene00013998", "G5EG47", "WBGene00010054", "O44625", "WBGene00004136", "Q9NEX2", "WBGene00013736", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q95ZS0", "WBGene00006392", "Q9GZI6", "WBGene00006387", "G5EF68", "WBGene00006386", "O45784", "WBGene00006391", "P32085", "WBGene00006542", "O61707", "WBGene00006385", "Q9NEW8", "WBGene00006389", "Q9TYN3", "WBGene00006383", "Q18265", "WBGene00016173", "Q17957", "WBGene00006397", "E9P861", "WBGene00006384", "Q20361", "WBGene00006395", "G5EGM3", "WBGene00006382", "O16991", "WBGene00006648", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "G5EG49", "WBGene00013998", "G5EG47", "WBGene00010054", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "O44625", "WBGene00004136", "Q9NEX2", "WBGene00013736", "Q95ZS0", "WBGene00006392", "Q9GZI6", "WBGene00006387", "G5EF68", "WBGene00006386", "O45784", "WBGene00006391", "P32085", "WBGene00006542", "O61707", "WBGene00006385", "Q9NEW8", "WBGene00006389", "Q9TYN3", "WBGene00006383", "Q18265", "WBGene00016173", "Q17957", "WBGene00006397", "E9P861", "WBGene00006384", "Q20361", "WBGene00006395", "G5EGM3", "WBGene00006382", "O16991", "WBGene00006648", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529" ] }, "reaction_10568438": { "compartment": "compartment_7660", "id": "reaction_10568438", "reactome": "R-CEL-8938913", "name": "RUNX1 binds ELF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10566201", "species_10568434" ], "products": [ "species_10568436" ], "modifiers": [], "additional_components": [ "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "WBGene00016029", "H2KYY1", "WBGene00016029", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393" ] }, "reaction_10558118": { "compartment": "compartment_70101", "id": "reaction_10558118", "reactome": "R-CEL-6785648", "name": "MEMO1 binds RHOA:GTP:DIAPH1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10558114", "species_10554688" ], "products": [ "species_10558116" ], "modifiers": [], "additional_components": [ "Q22915", "WBGene00016500", "Q22038", "WBGene00004357", "species_29438", "Q19479", "WBGene00008848", "Q7JP75", "WBGene00000872", "Q22038", "WBGene00004357", "species_29438", "Q19479", "WBGene00008848", "Q7JP75", "WBGene00000872", "Q22915", "WBGene00016500" ] }, "reaction_10520920": { "compartment": "compartment_70101", "id": "reaction_10520920", "reactome": "R-CEL-391266", "name": "Association of CCT/TriC with sphingosine kinase 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10520872", "species_10520916" ], "products": [ "species_10520918" ], "modifiers": [], "additional_components": [ "WBGene00007918", "P46550", "WBGene00000381", "Q9TZS5", "WBGene00020391", "P47207", "WBGene00000378", "Q9N4J8", "WBGene00018782", "P47208", "WBGene00000379", "species_113582", "Q9N358", "WBGene00021934", "P47209", "WBGene00000380", "P41988", "WBGene00000377", "P46550", "WBGene00000381", "Q9TZS5", "WBGene00020391", "P47207", "WBGene00000378", "Q9N4J8", "WBGene00018782", "P47208", "WBGene00000379", "species_113582", "Q9N358", "WBGene00021934", "P47209", "WBGene00000380", "P41988", "WBGene00000377", "Q18425", "WBGene00007918" ] }, "reaction_10564273": { "compartment": "compartment_70101", "id": "reaction_10564273", "reactome": "R-CEL-6814418", "name": "PDCL promotes formation of G-beta:G-gamma heterodimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509151", "species_10564267" ], "products": [ "species_10564271" ], "modifiers": [], "additional_components": [ "P54406", "WBGene00001681", "P17343", "WBGene00001679", "Q9U1X7", "WBGene00003142", "Q9U1X7", "WBGene00003142", "P17343", "WBGene00001679", "P54406", "WBGene00001681" ] }, "reaction_10565025": { "compartment": "compartment_70101", "id": "reaction_10565025", "reactome": "R-CEL-8850560", "name": "G-protein alpha releases G-protein heterotrimer from PDCL ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10564271", "species_10508935" ], "products": [ "species_10565023", "species_10564228" ], "modifiers": [], "additional_components": [ "Q9U1X7", "WBGene00003142", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196", "P17343", "WBGene00001679", "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196", "P54406", "WBGene00001681", "WBGene00003142" ] }, "reaction_10564213": { "compartment": "compartment_70101", "id": "reaction_10564213", "reactome": "R-CEL-6814119", "name": "TRiC/CCT binds unfolded G-protein beta subunit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509163", "species_10520916" ], "products": [ "species_10564211" ], "modifiers": [], "additional_components": [ "P17343", "WBGene00001679", "P46550", "WBGene00000381", "Q9TZS5", "WBGene00020391", "P47207", "WBGene00000378", "Q9N4J8", "WBGene00018782", "P47208", "WBGene00000379", "species_113582", "Q9N358", "WBGene00021934", "P47209", "WBGene00000380", "P41988", "WBGene00000377", "P46550", "WBGene00000381", "Q9TZS5", "WBGene00020391", "P47207", "WBGene00000378", "Q9N4J8", "WBGene00018782", "P47208", "WBGene00000379", "species_113582", "Q9N358", "WBGene00021934", "P47209", "WBGene00000380", "P41988", "WBGene00000377", "P17343", "WBGene00001679" ] }, "reaction_10565013": { "compartment": "compartment_70101", "id": "reaction_10565013", "reactome": "R-CEL-8850529", "name": "RGS proteins bind GNB5 and CCT/TRiC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10565009", "species_10564993" ], "products": [ "species_10565011" ], "modifiers": [], "additional_components": [ "P49809", "WBGene00001179", "O17589", "WBGene00001145", "P46550", "WBGene00000381", "Q9TZS5", "WBGene00020391", "P47207", "WBGene00000378", "Q9N4J8", "WBGene00018782", "P47208", "WBGene00000379", "species_113582", "Q9N358", "WBGene00021934", "P47209", "WBGene00000380", "P41988", "WBGene00000377", "Q20636", "WBGene00001680", "P46550", "WBGene00000381", "Q9TZS5", "WBGene00020391", "P47207", "WBGene00000378", "Q9N4J8", "WBGene00018782", "P47208", "WBGene00000379", "species_113582", "Q9N358", "WBGene00021934", "P47209", "WBGene00000380", "P41988", "WBGene00000377", "Q20636", "WBGene00001680", "P49809", "WBGene00001179", "O17589", "WBGene00001145" ] }, "reaction_10564265": { "compartment": "compartment_70101", "id": "reaction_10564265", "reactome": "R-CEL-6814409", "name": "CK2 phosphorylates PDCL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10564263" ], "products": [ "species_29370", "species_10564228" ], "modifiers": [ [ "species_10515097", "catalyst" ] ], "additional_components": [ "WBGene00003142", "WBGene00003142", "P18334", "WBGene00002191", "P28548", "WBGene00002196" ] }, "reaction_10565017": { "compartment": "compartment_70101", "id": "reaction_10565017", "reactome": "R-CEL-8850534", "name": "PDCL promotes G-protein beta 5 folding", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10565015" ], "products": [ "species_10564228", "species_10564993" ], "modifiers": [], "additional_components": [ "P46550", "WBGene00000381", "Q9TZS5", "WBGene00020391", "P47207", "WBGene00000378", "Q9N4J8", "WBGene00018782", "P47208", "WBGene00000379", "species_113582", "Q9N358", "WBGene00021934", "P47209", "WBGene00000380", "P41988", "WBGene00000377", "Q20636", "WBGene00001680", "Q9U1X7", "WBGene00003142", "WBGene00003142", "P46550", "WBGene00000381", "Q9TZS5", "WBGene00020391", "P47207", "WBGene00000378", "Q9N4J8", "WBGene00018782", "P47208", "WBGene00000379", "species_113582", "Q9N358", "WBGene00021934", "P47209", "WBGene00000380", "P41988", "WBGene00000377", "Q20636", "WBGene00001680" ] }, "reaction_10564232": { "compartment": "compartment_70101", "id": "reaction_10564232", "reactome": "R-CEL-6814121", "name": "PDCL binds G-protein beta and TRiC/CCT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10564228", "species_10564211" ], "products": [ "species_10564230" ], "modifiers": [], "additional_components": [ "WBGene00003142", "P46550", "WBGene00000381", "Q9TZS5", "WBGene00020391", "P47207", "WBGene00000378", "Q9N4J8", "WBGene00018782", "P47208", "WBGene00000379", "species_113582", "Q9N358", "WBGene00021934", "P47209", "WBGene00000380", "P41988", "WBGene00000377", "P17343", "WBGene00001679", "P46550", "WBGene00000381", "Q9TZS5", "WBGene00020391", "P47207", "WBGene00000378", "Q9N4J8", "WBGene00018782", "P47208", "WBGene00000379", "species_113582", "Q9N358", "WBGene00021934", "P47209", "WBGene00000380", "P41988", "WBGene00000377", "P17343", "WBGene00001679", "Q9U1X7", "WBGene00003142" ] }, "reaction_10564219": { "compartment": "compartment_70101", "id": "reaction_10564219", "reactome": "R-CEL-6814120", "name": "ATP hydrolysis promotes folding of G-protein beta by TRiC/CCT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10564217" ], "products": [ "species_29372", "species_10564211" ], "modifiers": [], "additional_components": [ "P46550", "WBGene00000381", "Q9TZS5", "WBGene00020391", "P47207", "WBGene00000378", "Q9N4J8", "WBGene00018782", "P47208", "WBGene00000379", "species_29358", "Q9N358", "WBGene00021934", "P47209", "WBGene00000380", "P41988", "WBGene00000377", "P17343", "WBGene00001679", "P46550", "WBGene00000381", "Q9TZS5", "WBGene00020391", "P47207", "WBGene00000378", "Q9N4J8", "WBGene00018782", "P47208", "WBGene00000379", "species_113582", "Q9N358", "WBGene00021934", "P47209", "WBGene00000380", "P41988", "WBGene00000377", "P17343", "WBGene00001679" ] }, "reaction_10564234": { "compartment": "compartment_70101", "id": "reaction_10564234", "reactome": "R-CEL-6814124", "name": "ATP binds G-protein beta associated TRiC/CCT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10564211" ], "products": [ "species_29370", "species_10564217" ], "modifiers": [], "additional_components": [ "P46550", "WBGene00000381", "Q9TZS5", "WBGene00020391", "P47207", "WBGene00000378", "Q9N4J8", "WBGene00018782", "P47208", "WBGene00000379", "species_113582", "Q9N358", "WBGene00021934", "P47209", "WBGene00000380", "P41988", "WBGene00000377", "P17343", "WBGene00001679", "P46550", "WBGene00000381", "Q9TZS5", "WBGene00020391", "P47207", "WBGene00000378", "Q9N4J8", "WBGene00018782", "P47208", "WBGene00000379", "species_29358", "Q9N358", "WBGene00021934", "P47209", "WBGene00000380", "P41988", "WBGene00000377", "P17343", "WBGene00001679" ] }, "reaction_10565021": { "compartment": "compartment_70101", "id": "reaction_10565021", "reactome": "R-CEL-8850539", "name": "Release of GNB5:RGS dimers from CCT/TRiC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10565011" ], "products": [ "species_10565019", "species_10520916" ], "modifiers": [], "additional_components": [ "P46550", "WBGene00000381", "Q9TZS5", "WBGene00020391", "P47207", "WBGene00000378", "Q9N4J8", "WBGene00018782", "P47208", "WBGene00000379", "species_113582", "Q9N358", "WBGene00021934", "P47209", "WBGene00000380", "P41988", "WBGene00000377", "Q20636", "WBGene00001680", "P49809", "WBGene00001179", "O17589", "WBGene00001145", "P49809", "WBGene00001179", "O17589", "WBGene00001145", "Q20636", "WBGene00001680", "P46550", "WBGene00000381", "Q9TZS5", "WBGene00020391", "P47207", "WBGene00000378", "Q9N4J8", "WBGene00018782", "P47208", "WBGene00000379", "species_113582", "Q9N358", "WBGene00021934", "P47209", "WBGene00000380", "P41988", "WBGene00000377" ] }, "reaction_10564991": { "compartment": "compartment_70101", "id": "reaction_10564991", "reactome": "R-CEL-8850527", "name": "PDCL releases folded G-beta from TRiC/CCT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10564989" ], "products": [ "species_10564267", "species_10520916" ], "modifiers": [], "additional_components": [ "Q9U1X7", "WBGene00003142", "P46550", "WBGene00000381", "Q9TZS5", "WBGene00020391", "P47207", "WBGene00000378", "Q9N4J8", "WBGene00018782", "P47208", "WBGene00000379", "species_113582", "Q9N358", "WBGene00021934", "P47209", "WBGene00000380", "P41988", "WBGene00000377", "P17343", "WBGene00001679", "P17343", "WBGene00001679", "Q9U1X7", "WBGene00003142", "P46550", "WBGene00000381", "Q9TZS5", "WBGene00020391", "P47207", "WBGene00000378", "Q9N4J8", "WBGene00018782", "P47208", "WBGene00000379", "species_113582", "Q9N358", "WBGene00021934", "P47209", "WBGene00000380", "P41988", "WBGene00000377" ] }, "reaction_10524242": { "compartment": "compartment_876", "id": "reaction_10524242", "reactome": "R-CEL-437300", "name": "SLC31A1 transports Cu2+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_437295" ], "products": [ "species_209799" ], "modifiers": [ [ "species_10524239", "catalyst" ] ], "additional_components": [ "WBGene00017852" ] }, "reaction_10524450": { "compartment": "compartment_876", "id": "reaction_10524450", "reactome": "R-CEL-442661", "name": "SLC41A1,2 transport Mg2+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_114632" ], "products": [ "species_29926" ], "modifiers": [ [ "species_10524447", "catalyst" ] ], "additional_components": [ "O02340", "WBGene00022682", "O44196", "WBGene00022682", "O45182", "WBGene00022682" ] }, "reaction_10524215": { "compartment": "compartment_1462052", "id": "reaction_10524215", "reactome": "R-CEL-437085", "name": "ZnT5 transports zinc into secretory granules in pancreatic beta cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29426" ], "products": [ "species_216785" ], "modifiers": [ [ "species_10524212", "catalyst" ] ], "additional_components": [ "WBGene00013668" ] }, "reaction_10524231": { "compartment": "compartment_20699", "id": "reaction_10524231", "reactome": "R-CEL-437139", "name": "ZnT6 transports zinc into the golgi apparatus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29426" ], "products": [ "species_216667" ], "modifiers": [ [ "species_10524228", "catalyst" ] ], "additional_components": [ "WBGene00006590" ] }, "reaction_10524207": { "compartment": "compartment_876", "id": "reaction_10524207", "reactome": "R-CEL-435366", "name": "ZnT1 mediates the efflux of zinc from the cell", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29426" ], "products": [ "species_158417" ], "modifiers": [ [ "species_10524204", "catalyst" ] ], "additional_components": [ "WBGene00000393" ] }, "reaction_10524223": { "compartment": "compartment_20699", "id": "reaction_10524223", "reactome": "R-CEL-437136", "name": "SLC30A8 transports Zn2+ from cytosol to secretory granule", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29426" ], "products": [ "species_216785" ], "modifiers": [ [ "species_10524220", "catalyst" ] ], "additional_components": [ "WBGene00011821" ] }, "reaction_10524385": { "compartment": "compartment_12045", "id": "reaction_10524385", "reactome": "R-CEL-442393", "name": "ZIP7 mediates zinc efflux from the endoplasmic reticulum", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_442320" ], "products": [ "species_29426" ], "modifiers": [ [ "species_10524382", "catalyst" ] ], "additional_components": [ "WBGene00006494" ] }, "reaction_10524344": { "compartment": "compartment_876", "id": "reaction_10524344", "reactome": "R-CEL-442317", "name": "ZIP6 and ZIP14 mediate zinc influx into cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158417" ], "products": [ "species_29426" ], "modifiers": [ [ "species_10524341", "catalyst" ] ], "additional_components": [ "U4PS08", "WBGene00021936", "Q22395", "WBGene00006486" ] }, "reaction_10524377": { "compartment": "compartment_876", "id": "reaction_10524377", "reactome": "R-CEL-442387", "name": "ZIP8 mediates zinc influx into cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158417" ], "products": [ "species_29426" ], "modifiers": [ [ "species_10524374", "catalyst" ] ], "additional_components": [ "Q22395", "WBGene00006486", "U4PS08", "WBGene00021936" ] }, "reaction_10524426": { "compartment": "compartment_876", "id": "reaction_10524426", "reactome": "R-CEL-442422", "name": "SLC39A1-4 transports Zn2+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158417" ], "products": [ "species_29426" ], "modifiers": [ [ "species_10524423", "catalyst" ] ], "additional_components": [ "Q09957", "WBGene00015940", "U4PS08", "WBGene00021936", "P91348", "WBGene00018897", "Q19913", "WBGene00017936", "Q6BEU0", "WBGene00014669", "O62192", "WBGene00009286", "Q9XWH3", "WBGene00013207" ] }, "reaction_10524199": { "compartment": "compartment_876", "id": "reaction_10524199", "reactome": "R-CEL-435349", "name": "SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_435347" ], "products": [ "species_70106", "species_71067" ], "modifiers": [ [ "species_10524196", "catalyst" ] ], "additional_components": [ "WBGene00004876" ] }, "reaction_10570186": { "compartment": "compartment_70101", "id": "reaction_10570186", "reactome": "R-CEL-8959798", "name": "SLC30A10 transports Mn2+ from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29418" ], "products": [ "species_266099" ], "modifiers": [ [ "species_10570183", "catalyst" ] ], "additional_components": [ "WBGene00000393" ] }, "reaction_10524366": { "compartment": "compartment_876", "id": "reaction_10524366", "reactome": "R-CEL-442368", "name": "SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71067" ], "products": [ "species_435347" ], "modifiers": [ [ "species_10524363", "catalyst" ] ], "additional_components": [ "O44607", "WBGene00019977", "Q8IA95", "WBGene00021354", "CHEBI:28694", "Q19687", "WBGene00009008" ] }, "reaction_10528430": { "compartment": "compartment_876", "id": "reaction_10528430", "reactome": "R-CEL-904830", "name": "SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71067" ], "products": [ "species_435347" ], "modifiers": [ [ "species_10528427", "catalyst" ] ], "additional_components": [ "Q19687", "WBGene00009008", "species_209799", "O44607", "WBGene00019977", "Q8IA95", "WBGene00021354" ] }, "reaction_10507115": { "compartment": "compartment_7660", "id": "reaction_10507115", "reactome": "R-CEL-75079", "name": "Formation of AT-AC C complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10507111" ], "products": [ "species_10507103", "species_10507113" ], "modifiers": [], "additional_components": [ "Q17348", "WBGene00004914", "Q9N4G9", "WBGene00004920", "Q18786", "WBGene00004917", "P91918", "WBGene00004915", "Q9XTU6", "WBGene00004919", "Q10013", "WBGene00004916", "P34659", "WBGene00004918", "Q23463", "WBGene00001166", "O02097", "WBGene00015974", "P92022", "WBGene00001808", "Q21568", "WBGene00010896", "Q9U2G0", "WBGene00012896", "Q95QN2", "WBGene00017162", "P34369", "WBGene00004187", "Q9GRZ2", "WBGene00013343", "L8E6I4", "WBGene00235102", "Q23120", "WBGene00004699", "Q9NEW6", "WBGene00004700", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "Q09511", "WBGene00004701", "O44985", "WBGene00019323", "G5EEQ8", "WBGene00011605", "Q8ITY4", "WBGene00016808", "O16997", "WBGene00021004", "Q93382", "WBGene00008119", "P91306", "WBGene00000473", "Q17348", "WBGene00004914", "Q9N4G9", "WBGene00004920", "Q18786", "WBGene00004917", "P91918", "WBGene00004915", "Q9XTU6", "WBGene00004919", "Q10013", "WBGene00004916", "P34659", "WBGene00004918", "Q23120", "WBGene00004699", "Q9NEW6", "WBGene00004700", "Q17348", "WBGene00004914", "Q9N4G9", "WBGene00004920", "Q18786", "WBGene00004917", "P91918", "WBGene00004915", "Q9XTU6", "WBGene00004919", "Q10013", "WBGene00004916", "P34659", "WBGene00004918", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "Q09511", "WBGene00004701", "O44985", "WBGene00019323", "G5EEQ8", "WBGene00011605", "Q8ITY4", "WBGene00016808", "O16997", "WBGene00021004", "Q93382", "WBGene00008119", "P91306", "WBGene00000473", "Q23463", "WBGene00001166", "O02097", "WBGene00015974", "P92022", "WBGene00001808", "Q21568", "WBGene00010896", "Q9U2G0", "WBGene00012896", "Q95QN2", "WBGene00017162", "P34369", "WBGene00004187", "Q9GRZ2", "WBGene00013343", "L8E6I4", "WBGene00235102" ] }, "reaction_10507117": { "compartment": "compartment_7660", "id": "reaction_10507117", "reactome": "R-CEL-75082", "name": "ATAC spliceosome mediated Lariat formation,5' splice site cleavage", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10507113" ], "products": [ "species_10507113" ], "modifiers": [], "additional_components": [ "Q23120", "WBGene00004699", "Q9NEW6", "WBGene00004700", "Q17348", "WBGene00004914", "Q9N4G9", "WBGene00004920", "Q18786", "WBGene00004917", "P91918", "WBGene00004915", "Q9XTU6", "WBGene00004919", "Q10013", "WBGene00004916", "P34659", "WBGene00004918", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "Q09511", "WBGene00004701", "O44985", "WBGene00019323", "G5EEQ8", "WBGene00011605", "Q8ITY4", "WBGene00016808", "O16997", "WBGene00021004", "Q93382", "WBGene00008119", "P91306", "WBGene00000473", "Q23463", "WBGene00001166", "O02097", "WBGene00015974", "P92022", "WBGene00001808", "Q21568", "WBGene00010896", "Q9U2G0", "WBGene00012896", "Q95QN2", "WBGene00017162", "P34369", "WBGene00004187", "Q9GRZ2", "WBGene00013343", "L8E6I4", "WBGene00235102", "Q23120", "WBGene00004699", "Q9NEW6", "WBGene00004700", "Q17348", "WBGene00004914", "Q9N4G9", "WBGene00004920", "Q18786", "WBGene00004917", "P91918", "WBGene00004915", "Q9XTU6", "WBGene00004919", "Q10013", "WBGene00004916", "P34659", "WBGene00004918", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "Q09511", "WBGene00004701", "O44985", "WBGene00019323", "G5EEQ8", "WBGene00011605", "Q8ITY4", "WBGene00016808", "O16997", "WBGene00021004", "Q93382", "WBGene00008119", "P91306", "WBGene00000473", "Q23463", "WBGene00001166", "O02097", "WBGene00015974", "P92022", "WBGene00001808", "Q21568", "WBGene00010896", "Q9U2G0", "WBGene00012896", "Q95QN2", "WBGene00017162", "P34369", "WBGene00004187", "Q9GRZ2", "WBGene00013343", "L8E6I4", "WBGene00235102" ] }, "reaction_10505265": { "compartment": "compartment_7660", "id": "reaction_10505265", "reactome": "R-CEL-72139", "name": "Formation of the active Spliceosomal C (B*) complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10505258" ], "products": [ "species_10505262", "species_10505252" ], "modifiers": [ [ "species_10505258", "catalyst" ] ], "additional_components": [ "P34313", "WBGene00007400", "P91306", "WBGene00000473", "Q9U1Q7", "WBGene00001258", "Q18265", "WBGene00016173", "Q22307", "WBGene00004355", "Q17336", "WBGene00002957", "Q18409", "WBGene00004703", "Q9NEW6", "WBGene00004700", "Q22412", "WBGene00011722", "Q23120", "WBGene00004699", "Q966L5", "WBGene00017085", "Q965K2", "WBGene00018776", "Q21322", "WBGene00004385", "Q21323", "WBGene00004386", "Q20875", "WBGene00018967", "Q9N3S4", "WBGene00004389", "Q20966", "WBGene00010233", "O44985", "WBGene00019323", "G5EEQ8", "WBGene00011605", "Q8ITY4", "WBGene00016808", "O16997", "WBGene00021004", "Q93382", "WBGene00008119", "Q22469", "WBGene00011758", "G5ECL3", "WBGene00004188", "Q19335", "WBGene00008683", "Q95Y51", "WBGene00004891", "G5EBY6", "WBGene00004016", 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10505213", "species_10505197", "species_10505225", "species_10505192", "species_10505175", "species_10505156" ], "products": [ "species_10505227" ], "modifiers": [], "additional_components": [ "Q93716", "WBGene00009668", "C1P629", "WBGene00008362", "WBGene00003904", "P52874", "WBGene00010304", "Q09345", "WBGene00020092", "Q09995", "WBGene00011791", "Q9U2P3", "WBGene00012528", "G5EBX5", "WBGene00009658", "O45577", "WBGene00000774", "Q19864", "WBGene00000773", "Q19866", "WBGene00006307", "Q95PY8", "WBGene00013460", "U4PCM1", "WBGene00011051", "Q9N4C2", "WBGene00022301", "Q7YTG9", "WBGene00044329", "O17403", "WBGene00017313", "O16929", "WBGene00017797", "Q95PY8", "WBGene00013460", "U4PCM1", "WBGene00011051", "Q9N4C2", "WBGene00022301", "Q7YTG9", "WBGene00044329", "O17403", "WBGene00017313", "O16929", "WBGene00017797", "O45577", "WBGene00000774", "Q19864", "WBGene00000773", "Q19866", "WBGene00006307", "Q09995", "WBGene00011791", "Q9U2P3", "WBGene00012528", "G5EBX5", "WBGene00009658", "P52874", "WBGene00010304", "Q09345", "WBGene00020092", "Q93233", "WBGene00003904", "Q93716", "WBGene00009668", "C1P629", "WBGene00008362" ] }, "reaction_10505260": { "compartment": "compartment_7660", "id": "reaction_10505260", "reactome": "R-CEL-72130", "name": "Formation of an intermediate Spliceosomal C (Bact) complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10505291", "species_10509834" ], "products": [ "species_10505299" ], "modifiers": [], "additional_components": [ "Q21832", "WBGene00004387", "P49029", "WBGene00003123", "Q9U1Q7", "WBGene00001258", "Q18265", "WBGene00016173", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "Q22307", "WBGene00004355", "Q17336", "WBGene00002957", "Q18409", "WBGene00004703", "Q9NEW6", "WBGene00004700", "Q22412", "WBGene00011722", "Q23120", "WBGene00004699", "Q966L5", "WBGene00017085", "Q965K2", "WBGene00018776", "Q21322", "WBGene00004385", "Q21323", "WBGene00004386", "Q20875", "WBGene00018967", "Q9N3S4", "WBGene00004389", "Q20966", "WBGene00010233", "O44985", "WBGene00019323", "G5EEQ8", "WBGene00011605", "Q8ITY4", "WBGene00016808", "O16997", "WBGene00021004", "Q93382", "WBGene00008119", "Q22469", "WBGene00011758", "G5ECL3", "WBGene00004188", "Q19335", "WBGene00008683", "Q95Y51", "WBGene00004891", "G5EBY6", 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demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10505377", "species_10507168" ], "products": [ "species_113550", "species_10509981", "species_10509975" ], "modifiers": [ [ "species_10505377", "catalyst" ] ], "additional_components": [ "Q9NEW6", "WBGene00004700", "O62185", "WBGene00004706", "Q21155", "WBGene00004388", "Q8WQF3", "WBGene00004882", "Q21559", "WBGene00000122", "Q9BL61", "WBGene00022029", "G5EDE4", "WBGene00012343", "Q21832", "WBGene00004387", "P49029", "WBGene00003123", "P34498", "WBGene00003389", "P90978", "WBGene00006697", "Q18409", "WBGene00004703", "O44729", "WBGene00018625", "Q9U2U0", "WBGene00006698", "Q23120", "WBGene00004699", "Q09511", "WBGene00004701", "P91867", "WBGene00009341", "C2BR94", "WBGene00021311", "Q9N5E3", "WBGene00020172", "Q18033", "WBGene00015813", "Q9U3S3", "WBGene00007195", "Q9N3G0", "WBGene00021813", "Q18212", "WBGene00001840", "species_29358", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "Q21278", "WBGene00010629", "Q9U757", "WBGene00003836", "Q9XVS8", "WBGene00003835", "Q9XVS7", "WBGene00003834", "Q9U757", "WBGene00003836", "Q9XVS8", "WBGene00003835", "Q9XVS7", "WBGene00003834", "O62185", "WBGene00004706", "Q21155", "WBGene00004388", "Q8WQF3", "WBGene00004882", "Q21559", "WBGene00000122", "Q9BL61", "WBGene00022029", "G5EDE4", "WBGene00012343", "Q21832", "WBGene00004387", "P49029", "WBGene00003123", "Q9NEW6", "WBGene00004700", "P34498", "WBGene00003389", "P90978", "WBGene00006697", "Q18409", "WBGene00004703", "O44729", "WBGene00018625", "Q9U2U0", "WBGene00006698", "Q23120", "WBGene00004699", "Q09511", "WBGene00004701", "P91867", "WBGene00009341", "C2BR94", "WBGene00021311", "Q9N5E3", "WBGene00020172", "Q18033", "WBGene00015813", "Q9U3S3", "WBGene00007195", "Q9N3G0", "WBGene00021813", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "Q21278", "WBGene00010629", "Q18212", "WBGene00001840", "species_113582", "Q9NEW6", "WBGene00004700", "O62185", "WBGene00004706", "Q21155", "WBGene00004388", "Q8WQF3", "WBGene00004882", "Q21559", "WBGene00000122", "Q9BL61", "WBGene00022029", "G5EDE4", "WBGene00012343", "Q21832", "WBGene00004387", "P49029", "WBGene00003123", "P34498", "WBGene00003389", "P90978", "WBGene00006697", "Q18409", "WBGene00004703", "O44729", "WBGene00018625", "Q9U2U0", "WBGene00006698", "Q23120", "WBGene00004699", "Q09511", "WBGene00004701", "P91867", "WBGene00009341", "C2BR94", "WBGene00021311", "Q9N5E3", "WBGene00020172", "Q18033", "WBGene00015813", "Q9U3S3", "WBGene00007195", "Q9N3G0", "WBGene00021813", "Q18212", "WBGene00001840", "species_29358", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "Q21278", "WBGene00010629" ] }, "reaction_10505380": { "compartment": "compartment_7660", "id": "reaction_10505380", "reactome": "R-CEL-72185", "name": "mRNA polyadenylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10505370" ], "products": [ "species_10505197", "species_10505192", "species_10505156", "species_10505377" ], "modifiers": [ [ "species_10505192", "catalyst" ] ], "additional_components": [ "Q9NEW6", "WBGene00004700", "O62185", "WBGene00004706", "Q21155", "WBGene00004388", "Q8WQF3", "WBGene00004882", "Q21559", "WBGene00000122", "Q9BL61", "WBGene00022029", "G5EDE4", "WBGene00012343", "Q21832", "WBGene00004387", "P49029", "WBGene00003123", "P34498", "WBGene00003389", "Q95PY8", "WBGene00013460", "U4PCM1", "WBGene00011051", "Q9N4C2", "WBGene00022301", "Q7YTG9", "WBGene00044329", "O17403", "WBGene00017313", "O16929", "WBGene00017797", "P90978", "WBGene00006697", "Q18409", "WBGene00004703", "Q09995", "WBGene00011791", "Q9U2P3", "WBGene00012528", "G5EBX5", "WBGene00009658", "O44729", "WBGene00018625", "Q9U2U0", "WBGene00006698", "Q93233", "WBGene00003904", "Q23120", "WBGene00004699", "Q09511", "WBGene00004701", "P91867", "WBGene00009341", "C2BR94", "WBGene00021311", "Q9N5E3", "WBGene00020172", "Q18033", "WBGene00015813", "Q9U3S3", "WBGene00007195", "Q9N3G0", "WBGene00021813", "Q18212", "WBGene00001840", "species_29358", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "Q21278", "WBGene00010629", "WBGene00003904", "Q09995", "WBGene00011791", "Q9U2P3", "WBGene00012528", "G5EBX5", "WBGene00009658", "Q95PY8", "WBGene00013460", "U4PCM1", "WBGene00011051", "Q9N4C2", "WBGene00022301", "Q7YTG9", "WBGene00044329", "O17403", "WBGene00017313", "O16929", "WBGene00017797", "Q9NEW6", "WBGene00004700", "O62185", "WBGene00004706", "Q21155", "WBGene00004388", "Q8WQF3", "WBGene00004882", "Q21559", "WBGene00000122", "Q9BL61", "WBGene00022029", "G5EDE4", "WBGene00012343", "Q21832", "WBGene00004387", "P49029", "WBGene00003123", "P34498", "WBGene00003389", "P90978", "WBGene00006697", "Q18409", "WBGene00004703", "O44729", "WBGene00018625", "Q9U2U0", "WBGene00006698", "Q23120", "WBGene00004699", "Q09511", "WBGene00004701", "P91867", "WBGene00009341", "C2BR94", "WBGene00021311", "Q9N5E3", "WBGene00020172", "Q18033", "WBGene00015813", "Q9U3S3", "WBGene00007195", "Q9N3G0", "WBGene00021813", "Q18212", "WBGene00001840", "species_29358", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "Q21278", "WBGene00010629", "Q09995", "WBGene00011791", "Q9U2P3", "WBGene00012528", "G5EBX5", "WBGene00009658" ] }, "reaction_10505375": { "compartment": "compartment_7660", "id": "reaction_10505375", "reactome": "R-CEL-72180", "name": "Cleavage of mRNA at the 3'-end", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10505368" ], "products": [ "species_10505213", "species_10505370", "species_10505225", "species_10505175" ], "modifiers": [ [ "species_10505372", "catalyst" ] ], "additional_components": [ "Q9NEW6", "WBGene00004700", "O62185", "WBGene00004706", "Q21155", "WBGene00004388", "Q8WQF3", "WBGene00004882", "Q21559", "WBGene00000122", "Q9BL61", "WBGene00022029", "G5EDE4", "WBGene00012343", "Q21832", "WBGene00004387", "P49029", "WBGene00003123", "P34498", "WBGene00003389", "P90978", "WBGene00006697", "Q18409", "WBGene00004703", "O44729", "WBGene00018625", "Q9U2U0", "WBGene00006698", "Q95PY8", "WBGene00013460", "U4PCM1", "WBGene00011051", "Q9N4C2", "WBGene00022301", "Q7YTG9", "WBGene00044329", "O17403", "WBGene00017313", "O16929", "WBGene00017797", "O45577", "WBGene00000774", "Q19864", "WBGene00000773", "Q19866", "WBGene00006307", "Q09995", "WBGene00011791", "Q9U2P3", "WBGene00012528", "G5EBX5", "WBGene00009658", "P52874", "WBGene00010304", "Q09345", "WBGene00020092", "Q93233", "WBGene00003904", "Q93716", "WBGene00009668", "C1P629", "WBGene00008362", "Q23120", "WBGene00004699", "Q09511", "WBGene00004701", "P91867", "WBGene00009341", "C2BR94", "WBGene00021311", "Q9N5E3", "WBGene00020172", "Q18033", "WBGene00015813", "Q9U3S3", "WBGene00007195", "Q9N3G0", "WBGene00021813", "Q18212", "WBGene00001840", "species_29358", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "Q21278", "WBGene00010629", "Q93716", "WBGene00009668", "C1P629", "WBGene00008362", "Q9NEW6", "WBGene00004700", "O62185", "WBGene00004706", "Q21155", "WBGene00004388", "Q8WQF3", "WBGene00004882", "Q21559", "WBGene00000122", "Q9BL61", "WBGene00022029", "G5EDE4", "WBGene00012343", "Q21832", "WBGene00004387", "P49029", "WBGene00003123", "P34498", "WBGene00003389", "Q95PY8", "WBGene00013460", "U4PCM1", "WBGene00011051", "Q9N4C2", "WBGene00022301", "Q7YTG9", "WBGene00044329", "O17403", "WBGene00017313", "O16929", "WBGene00017797", "P90978", "WBGene00006697", "Q18409", "WBGene00004703", "Q09995", "WBGene00011791", "Q9U2P3", "WBGene00012528", "G5EBX5", "WBGene00009658", "O44729", "WBGene00018625", "Q9U2U0", "WBGene00006698", "Q93233", "WBGene00003904", "Q23120", "WBGene00004699", "Q09511", "WBGene00004701", "P91867", "WBGene00009341", "C2BR94", "WBGene00021311", "Q9N5E3", "WBGene00020172", "Q18033", "WBGene00015813", "Q9U3S3", "WBGene00007195", "Q9N3G0", "WBGene00021813", "Q18212", "WBGene00001840", "species_29358", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "Q21278", "WBGene00010629", "P52874", "WBGene00010304", "Q09345", "WBGene00020092", "O45577", "WBGene00000774", "Q19864", "WBGene00000773", "Q19866", "WBGene00006307", "P52874", "WBGene00010304", "Q09345", "WBGene00020092", "Q93716", "WBGene00009668", "C1P629", "WBGene00008362" ] }, "reaction_10553705": { "compartment": "compartment_18730", "id": "reaction_10553705", "reactome": "R-CEL-5625426", "name": "Retrograde IFT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10553703" ], "products": [ "species_10553699" ], "modifiers": [], "additional_components": [ "species_29420", "species_29438", "Q19542", "WBGene00000485", "Q18263", "WBGene00016165", "Q19119", "WBGene00006960", "Q7YTJ8", "WBGene00012425", "A0AAC1", "WBGene00012424", "Q21557", "WBGene00010888", "Q22799", "WBGene00001005", "Q65XS9", "WBGene00043067", "Q22752", "WBGene00012004", "Q20255", "WBGene00022696", "G5ECZ4", "WBGene00001118", "Q18859", "WBGene00016935", "G5EFW7", "WBGene00000906", "P90757", "WBGene00000490", "Q0G838", "WBGene00001122", "G5EDF6", "WBGene00003886", "Q93833", "WBGene00000492", "A0A2C9C2L6", "WBGene00016005", "G5EGF0", "WBGene00000484", "A8DYR7", "WBGene00017973", "G5ED37", "WBGene00003885", "Q9XUC2", "WBGene00012132", "Q17595", "WBGene00001127", "Q6I6D4", "WBGene00001119", "Q95QT8", "WBGene00001129", "Q8I7G4", "WBGene00001117", "Q22830", "WBGene00003883", "Q8TA52", "WBGene00022465", "Q965T6", "WBGene00002230", "G5EEE6", "WBGene00002182", "Q19633", "WBGene00002222", "Q65XS9", "WBGene00043067", "Q7YTJ8", "WBGene00012425", "A0AAC1", "WBGene00012424", "Q21557", "WBGene00010888", "Q22799", "WBGene00001005", "Q22752", "WBGene00012004", "Q18263", "WBGene00016165", "Q19119", "WBGene00006960", "Q19542", "WBGene00000485", "species_29420", "species_29438", "Q19633", "WBGene00002222", "Q965T6", "WBGene00002230", "G5EEE6", "WBGene00002182", "Q17595", "WBGene00001127", "Q93833", "WBGene00000492", "Q6I6D4", "WBGene00001119", "A0A2C9C2L6", "WBGene00016005", "Q95QT8", "WBGene00001129", "G5EGF0", "WBGene00000484", "Q8I7G4", "WBGene00001117", "Q22830", "WBGene00003883", "A8DYR7", "WBGene00017973", "G5ED37", "WBGene00003885", "Q0G838", "WBGene00001122", "Q9XUC2", "WBGene00012132", "G5EDF6", "WBGene00003886", "Q8TA52", "WBGene00022465", "Q20255", "WBGene00022696", "G5EFW7", "WBGene00000906", "G5ECZ4", "WBGene00001118", "Q18859", "WBGene00016935", "P90757", "WBGene00000490" ] }, "reaction_10552842": { "compartment": "compartment_20699", "id": "reaction_10552842", "reactome": "R-CEL-5617828", "name": "TRIP11:IFT20 dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10552840" ], "products": [ "species_10552838", "species_10552833" ], "modifiers": [], "additional_components": [ "Q8TA52", "WBGene00022465", "D0Z5P0", "WBGene00013730", "WBGene00013730", "WBGene00022465" ] }, "reaction_10553695": { "compartment": "compartment_18730", "id": "reaction_10553695", "reactome": "R-CEL-5625416", "name": "Anterograde IFT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10553659" ], "products": [ "species_10553693" ], "modifiers": [], "additional_components": [ "Q65XS9", "WBGene00043067", "Q7YTJ8", "WBGene00012425", "A0AAC1", "WBGene00012424", "Q21557", "WBGene00010888", "Q22799", "WBGene00001005", "Q22752", "WBGene00012004", "Q18263", "WBGene00016165", "Q19119", "WBGene00006960", "Q19542", "WBGene00000485", "Q17595", "WBGene00001127", "Q93833", "WBGene00000492", "Q6I6D4", "WBGene00001119", "A0A2C9C2L6", "WBGene00016005", "Q95QT8", "WBGene00001129", "G5EGF0", "WBGene00000484", "Q8I7G4", "WBGene00001117", "Q22830", "WBGene00003883", "A8DYR7", "WBGene00017973", "G5ED37", "WBGene00003885", "Q0G838", "WBGene00001122", "Q9XUC2", "WBGene00012132", "G5EDF6", "WBGene00003886", "Q8TA52", "WBGene00022465", "species_29420", "species_29438", "Q19633", "WBGene00002222", "Q965T6", "WBGene00002230", "G5EEE6", "WBGene00002182", "Q20255", "WBGene00022696", "G5EFW7", "WBGene00000906", "G5ECZ4", "WBGene00001118", "Q18859", "WBGene00016935", "P90757", "WBGene00000490", "Q20255", "WBGene00022696", "G5ECZ4", "WBGene00001118", "Q18859", "WBGene00016935", "G5EFW7", "WBGene00000906", "P90757", "WBGene00000490", "Q19542", "WBGene00000485", "Q18263", "WBGene00016165", "Q19119", "WBGene00006960", "Q7YTJ8", "WBGene00012425", "A0AAC1", "WBGene00012424", "Q21557", "WBGene00010888", "Q22799", "WBGene00001005", "Q65XS9", "WBGene00043067", "Q22752", "WBGene00012004", "species_29420", "species_29438", "Q965T6", "WBGene00002230", "G5EEE6", "WBGene00002182", "Q19633", "WBGene00002222", "Q0G838", "WBGene00001122", "G5EDF6", "WBGene00003886", "Q93833", "WBGene00000492", "A0A2C9C2L6", "WBGene00016005", "G5EGF0", "WBGene00000484", "A8DYR7", "WBGene00017973", "G5ED37", "WBGene00003885", "Q9XUC2", "WBGene00012132", "Q17595", "WBGene00001127", "Q6I6D4", "WBGene00001119", "Q95QT8", "WBGene00001129", "Q8I7G4", "WBGene00001117", "Q22830", "WBGene00003883", "Q8TA52", "WBGene00022465" ] }, "reaction_10565360": { "compartment": "compartment_7660", "id": "reaction_10565360", "reactome": "R-CEL-8852131", "name": "Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502318", "species_29358", "species_10565305" ], "products": [ "species_10565307", "species_113541" ], "modifiers": [], "additional_components": [ "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "Q27481", "WBGene00006699", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "P49632", "WBGene00006728", "Q27481", "WBGene00006699" ] }, "reaction_10565363": { "compartment": "compartment_70101", "id": "reaction_10565363", "reactome": "R-CEL-8852132", "name": "Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10565228", "species_113592", "species_10502375" ], "products": [ "species_111294", "species_10565258" ], "modifiers": [ [ "species_10565228", "catalyst" ] ], "additional_components": [ "Q27481", "WBGene00006699", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "P49632", "WBGene00006728", "Q27481", "WBGene00006699", "Q27481", "WBGene00006699", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727" ] }, "reaction_10565303": { "compartment": "compartment_70101", "id": "reaction_10565303", "reactome": "R-CEL-8852129", "name": "UBA1 conjugates ubiquitin to cytosolic E2 enzymes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10565258", "species_10565226" ], "products": [ "species_10565260", "species_10565301" ], "modifiers": [], "additional_components": [ "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "P49632", "WBGene00006728", "Q27481", "WBGene00006699", "P35129", "WBGene00002344", "P91853", "WBGene00006732", "Q17720", "WBGene00006717", "Q9U1Q1", "WBGene00006709", "Q95XN7", "WBGene00006702", "Q9TZ69", "WBGene00006715", "Q9N2W9", "WBGene00006705", "H8W3X5", "WBGene00219376", "Q21633", "WBGene00006713", "P34477", "WBGene00006704", "Q93571", "WBGene00006720", "Q27481", "WBGene00006699", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "P49632", "WBGene00006728", "P34477", "WBGene00006704", "Q9U1Q1", "WBGene00006709", "Q9N2W9", "WBGene00006705", "Q9TZ69", "WBGene00006715", "P35129", "WBGene00002344", "P91853", "WBGene00006732", "Q17720", "WBGene00006717", "H8W3X5", "WBGene00219376", "Q21633", "WBGene00006713", "Q95XN7", "WBGene00006702", "Q93571", "WBGene00006720", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727" ] }, "reaction_10565366": { "compartment": "compartment_70101", "id": "reaction_10565366", "reactome": "R-CEL-8852133", "name": "UBA1 conjugates ubiquitin to UBA1 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10565260" ], "products": [ "species_10565228", "species_76577" ], "modifiers": [ [ "species_10565260", "catalyst" ] ], "additional_components": [ "Q27481", "WBGene00006699", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "P49632", "WBGene00006728", "Q27481", "WBGene00006699", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "Q27481", "WBGene00006699", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "P49632", "WBGene00006728" ] }, "reaction_10565369": { "compartment": "compartment_70101", "id": "reaction_10565369", "reactome": "R-CEL-8852134", "name": "UBA1 adenylates ubiquitin in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10502375", "species_10531318" ], "products": [ "species_111294", "species_10565260" ], "modifiers": [ [ "species_10531318", "catalyst" ] ], "additional_components": [ "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "WBGene00006699", "Q27481", "WBGene00006699", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "P49632", "WBGene00006728", "WBGene00006699" ] }, "reaction_10565432": { "compartment": "compartment_70101", "id": "reaction_10565432", "reactome": "R-CEL-8853514", "name": "UCHL3,USP7,USP9X cleaves UBA52 yielding ubiquitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10565425" ], "products": [ "species_10502349", "species_10505892" ], "modifiers": [ [ "species_10565429", "catalyst" ] ], "additional_components": [ "WBGene00006725", "WBGene00006725", "WBGene00006725", "Q7JKC3", "WBGene00010406", "Q9UAV3", "WBGene00006721" ] }, "reaction_10565224": { "compartment": "compartment_7660", "id": "reaction_10565224", "reactome": "R-CEL-8852128", "name": "UBA1 adenylates ubiquitin in the nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502318", "species_29358", "species_10565179" ], "products": [ "species_10565222", "species_113541" ], "modifiers": [], "additional_components": [ "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "WBGene00006699", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "P49632", "WBGene00006728", "Q27481", "WBGene00006699" ] }, "reaction_10565371": { "compartment": "compartment_7660", "id": "reaction_10565371", "reactome": "R-CEL-8852136", "name": "UBA1 conjugates ubiquitin to UBA1 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10565222" ], "products": [ "species_164121", "species_10565305" ], "modifiers": [], "additional_components": [ "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "P49632", "WBGene00006728", "Q27481", "WBGene00006699", "Q27481", "WBGene00006699", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725" ] }, "reaction_10565358": { "compartment": "compartment_7660", "id": "reaction_10565358", "reactome": "R-CEL-8852130", "name": "UBA1 conjugates ubiquitin to nuclear E2 enzymes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10565326", "species_10565307" ], "products": [ "species_10565356", "species_10565222" ], "modifiers": [], "additional_components": [ "H8W3X5", "WBGene00219376", "P35129", "WBGene00002344", "P91853", "WBGene00006732", "Q17720", "WBGene00006717", "Q21633", "WBGene00006713", "Q20872", "WBGene00006731", "Q95XN7", "WBGene00006702", "Q9XWF6", "WBGene00006711", "P52478", "WBGene00006701", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "P49632", "WBGene00006728", "Q27481", "WBGene00006699", "Q95XN7", "WBGene00006702", "H8W3X5", "WBGene00219376", "P52478", "WBGene00006701", "Q21633", "WBGene00006713", "Q20872", "WBGene00006731", "Q9XWF6", "WBGene00006711", "P35129", "WBGene00002344", "P91853", "WBGene00006732", "Q17720", "WBGene00006717", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "P49632", "WBGene00006728", "Q27481", "WBGene00006699" ] }, "reaction_10532323": { "compartment": "compartment_70101", "id": "reaction_10532323", "reactome": "R-CEL-1247645", "name": "RHAG transports CO2 from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113528" ], "products": [ "species_1237009" ], "modifiers": [ [ "species_10524631", "catalyst" ] ], "additional_components": [ "Q17463", "WBGene00004359", "Q22947", "WBGene00004358" ] }, "reaction_10534719": { "compartment": "compartment_70101", "id": "reaction_10534719", "reactome": "R-CEL-1475436", "name": "CA1:Zn2+,CA2:Zn2+ dehydrate HCO3- to CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_111627" ], "products": [ "species_29356", "species_113528" ], "modifiers": [ [ "species_10534714", "catalyst" ] ], "additional_components": [ "O02637", "WBGene00000284", "Q10462", "WBGene00000283", "Q21614", "WBGene00000282", "Q27504", "WBGene00000281", "species_216785" ] }, "reaction_10568241": { "compartment": "compartment_70101", "id": "reaction_10568241", "reactome": "R-CEL-8936849", "name": "AHR:2xHSP90:AIP:PTGES3 binds TCDD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8936852", "species_10568237" ], "products": [ "species_10568239" ], "modifiers": [], "additional_components": [ "Q18688", "WBGene00000915", "O44712", "WBGene00000096", "Q18888", "WBGene00016966", "Q23280", "WBGene00022599", "Q18688", "WBGene00000915", "O44712", "WBGene00000096", "Q18888", "WBGene00016966", "Q23280", "WBGene00022599", "species_8936852" ] }, "reaction_10568289": { "compartment": "compartment_7660", "id": "reaction_10568289", "reactome": "R-CEL-8937191", "name": "AHR:TCDD:2xHSP90AB1:AIP:PTGES3 dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10568281" ], "products": [ "species_10556878", "species_10568287" ], "modifiers": [], "additional_components": [ "Q18688", "WBGene00000915", "Q18888", "WBGene00016966", "Q23280", "WBGene00022599", "O44712", "WBGene00000096", "species_8936852", "species_8936852", "O44712", "WBGene00000096", "Q18688", "WBGene00000915", "Q18888", "WBGene00016966", "Q23280", "WBGene00022599" ] }, "reaction_10568243": { "compartment": "compartment_70101", "id": "reaction_10568243", "reactome": "R-CEL-8936851", "name": "AHRR binds ARNT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10532219", "species_10556884" ], "products": [ "species_10556886" ], "modifiers": [], "additional_components": [ "WBGene00000095", "WBGene00000096", "O44712", "WBGene00000096", "O02219", "WBGene00000095" ] }, "reaction_10568283": { "compartment": "compartment_70101", "id": "reaction_10568283", "reactome": "R-CEL-8937169", "name": "AHR:TCDD:2xHSP90AB1:AIP:PTGES3 translocates from cytosol to nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10568239" ], "products": [ "species_10568281" ], "modifiers": [], "additional_components": [ "Q18688", "WBGene00000915", "O44712", "WBGene00000096", "Q18888", "WBGene00016966", "Q23280", "WBGene00022599", "species_8936852", "Q18688", "WBGene00000915", "Q18888", "WBGene00016966", "Q23280", "WBGene00022599", "O44712", "WBGene00000096", "species_8936852" ] }, "reaction_10568285": { "compartment": "compartment_7660", "id": "reaction_10568285", "reactome": "R-CEL-8937177", "name": "AHR:TCDD binds ARNT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10556878", "species_10532219" ], "products": [ "species_10556882" ], "modifiers": [], "additional_components": [ "species_8936852", "O44712", "WBGene00000096", "WBGene00000095", "O02219", "WBGene00000095", "species_8936852", "O44712", "WBGene00000096" ] }, "reaction_10569050": { "compartment": "compartment_7660", "id": "reaction_10569050", "reactome": "R-CEL-8951676", "name": "RUNX3 binds TEADs and YAP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10566205", "species_10542185" ], "products": [ "species_10569048" ], "modifiers": [], "additional_components": [ "WBGene00004393", "Q19849", "WBGene00001208", "Q19404", "WBGene00008748", "Q19849", "WBGene00001208", "Q19404", "WBGene00008748", "G5EFQ5", "WBGene00004393" ] }, "reaction_10569036": { "compartment": "compartment_7660", "id": "reaction_10569036", "reactome": "R-CEL-8951428", "name": "RUNX3 binds CTNNB1:TCF7L2,(LEF1,TCF7L1,TCF7)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10566205", "species_10547172" ], "products": [ "species_10569034" ], "modifiers": [], "additional_components": [ "WBGene00004393", "Q10666", "WBGene00004077", "O44326", "WBGene00001979", "Q10666", "WBGene00004077", "O44326", "WBGene00001979", "G5EFQ5", "WBGene00004393" ] }, "reaction_10527860": { "compartment": "compartment_20699", "id": "reaction_10527860", "reactome": "R-CEL-741450", "name": "SLC35A3 exchanges UDP-GlcNAc for UMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_735698", "species_162756" ], "products": [ "species_914003", "species_109402" ], "modifiers": [ [ "species_10527857", "catalyst" ] ], "additional_components": [ "WBGene00015404" ] }, "reaction_10527876": { "compartment": "compartment_20699", "id": "reaction_10527876", "reactome": "R-CEL-742354", "name": "SLC35B4 mediates the transport of UDP-N-acetylglucosamine into the Golgi lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_162756" ], "products": [ "species_914003" ], "modifiers": [ [ "species_10527873", "catalyst" ] ], "additional_components": [ "WBGene00017480" ] }, "reaction_10527879": { "compartment": "compartment_20699", "id": "reaction_10527879", "reactome": "R-CEL-742373", "name": "SLC35B4 mediates the transport of UDP-xylose into the Golgi lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_742353" ], "products": [ "species_742361" ], "modifiers": [ [ "species_10527873", "catalyst" ] ], "additional_components": [ "WBGene00017480" ] }, "reaction_10527832": { "compartment": "compartment_20699", "id": "reaction_10527832", "reactome": "R-CEL-727807", "name": "SLC35A1 exchanges CMP-Neu5Ac for CMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_727810", "species_4085435" ], "products": [ "species_727815", "species_109395" ], "modifiers": [ [ "species_10527829", "catalyst" ] ], "additional_components": [ "Q93890", "WBGene00005153", "O01879", "WBGene00022577", "O02345", "WBGene00014139", "Q02334", "WBGene00022721" ] }, "reaction_10527868": { "compartment": "compartment_20699", "id": "reaction_10527868", "reactome": "R-CEL-742345", "name": "SLC35C1 transport UDP-Fuc from cytosol to Golgi lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_742368" ], "products": [ "species_205683" ], "modifiers": [ [ "species_10527865", "catalyst" ] ], "additional_components": [ "WBGene00008237" ] }, "reaction_10527884": { "compartment": "compartment_20699", "id": "reaction_10527884", "reactome": "R-CEL-744230", "name": "SLC35D2 mediates the antiport of GDP-mannose in exchange for GMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_162860", "species_744239" ], "products": [ "species_113578", "species_744233" ], "modifiers": [ [ "species_10527881", "catalyst" ] ], "additional_components": [ "WBGene00005025" ] }, "reaction_10527837": { "compartment": "compartment_20699", "id": "reaction_10527837", "reactome": "R-CEL-735702", "name": "SLC35A2 exchanges UDP-Gal, UDP-GalNAc for UMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_735698", "species_735692" ], "products": [ "species_109402", "species_735691" ], "modifiers": [ [ "species_10527834", "catalyst" ] ], "additional_components": [ "species_735700", "species_1981137", "species_1981137", "species_735700", "WBGene00005153" ] }, "reaction_10527886": { "compartment": "compartment_20699", "id": "reaction_10527886", "reactome": "R-CEL-744231", "name": "SLC35D2 exchanges UDP-sugars for UMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_744229", "species_735698" ], "products": [ "species_109402", "species_744234" ], "modifiers": [ [ "species_10527881", "catalyst" ] ], "additional_components": [ "species_173594", "species_914003", "species_173594", "species_914003", "WBGene00005025" ] }, "reaction_10508358": { "compartment": "compartment_7660", "id": "reaction_10508358", "reactome": "R-CEL-77613", "name": "Binding of ADAR2 homodimer to dsRNA duplex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_75086", "species_10508354" ], "products": [ "species_10508356" ], "modifiers": [], "additional_components": [ "Q22618", "WBGene00000080", "Q22618", "WBGene00000080" ] }, "reaction_10508826": { "compartment": "compartment_7660", "id": "reaction_10508826", "reactome": "R-CEL-111237", "name": "Formation of ADAR1 homodimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10507129" ], "products": [ "species_10507131" ], "modifiers": [], "additional_components": [ "Q93412", "WBGene00008397", "Q9U3D6", "WBGene00000079", "Q93412", "WBGene00008397", "Q9U3D6", "WBGene00000079" ] }, "reaction_10508828": { "compartment": "compartment_7660", "id": "reaction_10508828", "reactome": "R-CEL-111238", "name": "Formation of ADAR2 homodimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508352" ], "products": [ "species_10508354" ], "modifiers": [], "additional_components": [ "WBGene00000080", "Q22618", "WBGene00000080" ] }, "reaction_10507135": { "compartment": "compartment_7660", "id": "reaction_10507135", "reactome": "R-CEL-75090", "name": "Binding of ADAR1 homodimer to dsRNA duplex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_75086", "species_10507131" ], "products": [ "species_10507133" ], "modifiers": [], "additional_components": [ "Q93412", "WBGene00008397", "Q9U3D6", "WBGene00000079", "Q93412", "WBGene00008397", "Q9U3D6", "WBGene00000079" ] }, "reaction_10508368": { "compartment": "compartment_7660", "id": "reaction_10508368", "reactome": "R-CEL-77615", "name": "Deamination at C6 position of adenosine in Editosome (ADAR2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10508356" ], "products": [ "species_10508365", "species_76230" ], "modifiers": [ [ "species_10508354", "catalyst" ] ], "additional_components": [ "Q22618", "WBGene00000080", "Q22618", "WBGene00000080", "Q22618", "WBGene00000080" ] }, "reaction_10508363": { "compartment": "compartment_7660", "id": "reaction_10508363", "reactome": "R-CEL-77614", "name": "Deamination at C6 position of adenosine in Editosome (ADAR1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10507133" ], "products": [ "species_10508360", "species_76230" ], "modifiers": [ [ "species_10507131", "catalyst" ] ], "additional_components": [ "Q93412", "WBGene00008397", "Q9U3D6", "WBGene00000079", "Q93412", "WBGene00008397", "Q9U3D6", "WBGene00000079", "Q93412", "WBGene00008397", "Q9U3D6", "WBGene00000079" ] }, "reaction_10508608": { "compartment": "compartment_70101", "id": "reaction_10508608", "reactome": "R-CEL-109864", "name": "Dissociation of p-T,Y-MAPK1:p-S,T-MAP2K2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508601" ], "products": [ "species_10508573", "species_10508599" ], "modifiers": [], "additional_components": [ "P39745", "WBGene00003401", "Q10664", "WBGene00003186", "WBGene00003186", "WBGene00003401" ] }, "reaction_10508579": { "compartment": "compartment_70101", "id": "reaction_10508579", "reactome": "R-CEL-109858", "name": "MAP2K2 binds MAPK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508575", "species_10508573" ], "products": [ "species_10508577" ], "modifiers": [], "additional_components": [ "WBGene00003401", "WBGene00003186", "Q10664", "WBGene00003186", "P39745", "WBGene00003401" ] }, "reaction_10508604": { "compartment": "compartment_70101", "id": "reaction_10508604", "reactome": "R-CEL-109862", "name": "MAP2K2 phosphorylates MAPK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10508577" ], "products": [ "species_29370", "species_10508601" ], "modifiers": [ [ "species_10508577", "catalyst" ] ], "additional_components": [ "Q10664", "WBGene00003186", "P39745", "WBGene00003401", "P39745", "WBGene00003401", "Q10664", "WBGene00003186", "Q10664", "WBGene00003186", "P39745", "WBGene00003401" ] }, "reaction_10525426": { "compartment": "compartment_5460", "id": "reaction_10525426", "reactome": "R-CEL-449937", "name": "pyrophosphate + H2O => 2 orthophosphate [mitochondrial]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_159450", "species_113521" ], "products": [ "species_113548" ], "modifiers": [ [ "species_10525423", "catalyst" ], [ "species_109496", "catalyst" ] ], "additional_components": [ "Q18680", "WBGene00008149" ] }, "reaction_10504277": { "compartment": "compartment_70101", "id": "reaction_10504277", "reactome": "R-CEL-71732", "name": "pyrophosphate + H2O => 2 orthophosphate [cytosolic]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111294", "species_29356" ], "products": [ "species_29372" ], "modifiers": [ [ "species_10504274", "catalyst" ], [ "species_29926", "catalyst" ] ], "additional_components": [ "Q18680", "WBGene00008149" ] }, "reaction_10571313": { "compartment": "compartment_876", "id": "reaction_10571313", "reactome": "R-CEL-9017491", "name": "RHOJ GEFs activate RHOJ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10571305" ], "products": [ "species_29420", "species_10571303" ], "modifiers": [ [ "species_10531723", "catalyst" ] ], "additional_components": [ "O62422", "WBGene00012532", "Q05062", "WBGene00000390", "species_29420", "O62422", "WBGene00012532", "Q05062", "WBGene00000390", "species_29438", "WBGene00018520" ] }, "reaction_10571310": { "compartment": "compartment_876", "id": "reaction_10571310", "reactome": "R-CEL-9017488", "name": "RHOJ GAPs stimulate RHOJ GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10571303" ], "products": [ "species_29372", "species_10571305" ], "modifiers": [ [ "species_10571307", "catalyst" ] ], "additional_components": [ "O62422", "WBGene00012532", "Q05062", "WBGene00000390", "species_29438", "O62422", "WBGene00012532", "Q05062", "WBGene00000390", "species_29420", "O45611", "WBGene00010374", "H2KZV6", "WBGene00020209", "Q23130", "WBGene00012203" ] }, "reaction_10571008": { "compartment": "compartment_876", "id": "reaction_10571008", "reactome": "R-CEL-9013009", "name": "RHOA binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10571004", "species_10509488" ], "products": [ "species_10571006" ], "modifiers": [], "additional_components": [ "Q7JP75", "WBGene00000872", "Q19479", "WBGene00008848", "A0A4V0IKG6", "WBGene00007287", "G5EDU3", "WBGene00004040", "P92199", "WBGene00002694", "A0A4V0ILM7", "WBGene00009793", "D6VPA1", "WBGene00018976", "Q21025", "WBGene00019087", "Q9XVH4", "WBGene00019087", "Q17777", "WBGene00007409", "Q09994", "WBGene00019608", "O17772", "WBGene00003980", "Q22038", "WBGene00004357", "species_29438", "Q22038", "WBGene00004357", "species_29438", "Q7JP75", "WBGene00000872", "Q19479", "WBGene00008848", "A0A4V0IKG6", "WBGene00007287", "G5EDU3", "WBGene00004040", "P92199", "WBGene00002694", "A0A4V0ILM7", "WBGene00009793", "D6VPA1", "WBGene00018976", "Q21025", "WBGene00019087", "Q9XVH4", "WBGene00019087", "Q17777", "WBGene00007409", "Q09994", "WBGene00019608", "O17772", "WBGene00003980" ] }, "reaction_10570947": { "compartment": "compartment_70101", "id": "reaction_10570947", "reactome": "R-CEL-9012835", "name": "GDIs block activation of RHOA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509486", "species_10570939" ], "products": [ "species_10570945" ], "modifiers": [], "additional_components": [ "Q22038", "WBGene00004357", "species_29420", "WBGene00004356", "Q20496", "WBGene00004356", "Q22038", "WBGene00004357", "species_29420" ] }, "reaction_10570274": { "compartment": "compartment_70101", "id": "reaction_10570274", "reactome": "R-CEL-8980691", "name": "RHOA GEFs activate RHOA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10509486" ], "products": [ "species_29420", "species_10509488" ], "modifiers": [ [ "species_10570271", "catalyst" ] ], "additional_components": [ "Q22038", "WBGene00004357", "species_29420", "Q22038", "WBGene00004357", "species_29438", "G5EFE1", "WBGene00006468", "H2L0P5", "WBGene00022391", "O61528", "WBGene00006805", "A0A0K3AQN0", "WBGene00013682", "Q9U3P2", "WBGene00007750", "Q965J0", "WBGene00019487", "S6EZU2", "WBGene00006476", "Q45FX5", "WBGene00006887", "Q21653", "WBGene00019832", "H2KYI7", "WBGene00006496", "Q9U364", "WBGene00002297" ] }, "reaction_10570420": { "compartment": "compartment_70101", "id": "reaction_10570420", "reactome": "R-CEL-8981637", "name": "RHOA GAPs stimulate RHOA GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10509488" ], "products": [ "species_10509486", "species_29372" ], "modifiers": [ [ "species_10570417", "catalyst" ] ], "additional_components": [ "Q22038", "WBGene00004357", "species_29438", "Q22038", "WBGene00004357", "species_29420", "H2KZV6", "WBGene00020209", "O45611", "WBGene00010374", "Q20498", "WBGene00009800", "O01443", "WBGene00015303", "A0A0K3AW57", "Y75B7AL.4c", "U4PAK0", "WBGene00007064", "Q9XW53", "WBGene00013135", "Q20440", "WBGene00001559", "Q23130", "WBGene00012203", "G5EF80", "WBGene00014051" ] }, "reaction_10570951": { "compartment": "compartment_876", "id": "reaction_10570951", "reactome": "R-CEL-9013006", "name": "RHOA:GTP translocates to the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509488" ], "products": [ "species_10570949" ], "modifiers": [], "additional_components": [ "Q22038", "WBGene00004357", "species_29438", "Q22038", "WBGene00004357", "species_29438" ] }, "reaction_10571347": { "compartment": "compartment_876", "id": "reaction_10571347", "reactome": "R-CEL-9018747", "name": "RHOQ GEFs activate RHOQ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10571331" ], "products": [ "species_29420", "species_10553913" ], "modifiers": [ [ "species_10571344", "catalyst" ] ], "additional_components": [ "O62422", "WBGene00012532", "Q05062", "WBGene00000390", "species_29420", "O62422", "WBGene00012532", "Q05062", "WBGene00000390", "species_29438", "Q9U3P2", "WBGene00007750", "A0A0K3AS36", "Y116A8C.36d" ] }, "reaction_10571336": { "compartment": "compartment_70101", "id": "reaction_10571336", "reactome": "R-CEL-9018745", "name": "RHOQ GAPs stimulate RHOQ GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10553913" ], "products": [ "species_29372", "species_10571331" ], "modifiers": [ [ "species_10571333", "catalyst" ] ], "additional_components": [ "O62422", "WBGene00012532", "Q05062", "WBGene00000390", "species_29438", "O62422", "WBGene00012532", "Q05062", "WBGene00000390", "species_29420", "Q20440", "WBGene00001559", "H2KZV6", "WBGene00020209", "Q23130", "WBGene00012203" ] }, "reaction_10553928": { "compartment": "compartment_13949", "id": "reaction_10553928", "reactome": "R-CEL-5627072", "name": "RHOQ binds GOPC:CFTR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10553903", "species_10553892" ], "products": [ "species_10553905" ], "modifiers": [], "additional_components": [ "O62422", "WBGene00012532", "Q05062", "WBGene00000390", "species_29438", "Q19625", "WBGene00003412", "Q95QV2", "WBGene00000477", "O18302", "WBGene00014101", "Q19625", "WBGene00003412", "Q95QV2", "WBGene00000477", "O18302", "WBGene00014101", "O62422", "WBGene00012532", "Q05062", "WBGene00000390", "species_29438" ] }, "reaction_10571342": { "compartment": "compartment_70101", "id": "reaction_10571342", "reactome": "R-CEL-9018746", "name": "RHOQ binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10571338", "species_10553913" ], "products": [ "species_10571340" ], "modifiers": [], "additional_components": [ "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "Q20498", "WBGene00009800", "Q19253", "WBGene00017298", "Q9XUS7", "WBGene00010663", "O17772", "WBGene00003980", "O62422", "WBGene00012532", "Q05062", "WBGene00000390", "species_29438", "O62422", "WBGene00012532", "Q05062", "WBGene00000390", "species_29438", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "Q20498", "WBGene00009800", "Q19253", "WBGene00017298", "Q9XUS7", "WBGene00010663", "O17772", "WBGene00003980" ] }, "reaction_10571470": { "compartment": "compartment_876", "id": "reaction_10571470", "reactome": "R-CEL-9018836", "name": "RHOQ translocates to the Golgi-associated vesicle membranes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10553913" ], "products": [ "species_10553903" ], "modifiers": [], "additional_components": [ "O62422", "WBGene00012532", "Q05062", "WBGene00000390", "species_29438", "O62422", "WBGene00012532", "Q05062", "WBGene00000390", "species_29438" ] }, "reaction_10571361": { "compartment": "compartment_876", "id": "reaction_10571361", "reactome": "R-CEL-9018754", "name": "GDIs bind RHOH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10571357", "species_10570939" ], "products": [ "species_10571359" ], "modifiers": [], "additional_components": [ "Q03206", "ced-10", "Q94124", "WBGene00004287", "Q9BL44", "WBGene00022177", "species_29438", "WBGene00004356", "Q20496", "WBGene00004356", "Q03206", "ced-10", "Q94124", "WBGene00004287", "Q9BL44", "WBGene00022177", "species_29438" ] }, "reaction_10571393": { "compartment": "compartment_876", "id": "reaction_10571393", "reactome": "R-CEL-9018758", "name": "RHOH binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10571389", "species_10571357" ], "products": [ "species_10571391" ], "modifiers": [], "additional_components": [ "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "G5EFU0", "WBGene00006443", "Q18462", "WBGene00016416", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "G5ECJ6", "WBGene00000812", "Q03206", "ced-10", "Q94124", "WBGene00004287", "Q9BL44", "WBGene00022177", "species_29438", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "G5EFU0", "WBGene00006443", "Q18462", "WBGene00016416", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "G5ECJ6", "WBGene00000812", "Q03206", "ced-10", "Q94124", "WBGene00004287", "Q9BL44", "WBGene00022177", "species_29438" ] }, "reaction_10571363": { "compartment": "compartment_876", "id": "reaction_10571363", "reactome": "R-CEL-9018756", "name": "RHOH binds GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10571355" ], "products": [ "species_10571357" ], "modifiers": [], "additional_components": [ "Q03206", "ced-10", "Q94124", "WBGene00004287", "Q9BL44", "WBGene00022177", "Q03206", "ced-10", "Q94124", "WBGene00004287", "Q9BL44", "WBGene00022177", "species_29438" ] }, "reaction_10571418": { "compartment": "compartment_876", "id": "reaction_10571418", "reactome": "R-CEL-9018766", "name": "RHOU binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10571400", "species_10571414" ], "products": [ "species_10571416" ], "modifiers": [], "additional_components": [ "Q19739", "WBGene00009059", "species_29438", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "G5EFU0", "WBGene00006443", "Q20498", "WBGene00009800", "Q95PX0", "WBGene00006410", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "G5EFU0", "WBGene00006443", "Q20498", "WBGene00009800", "Q95PX0", "WBGene00006410", "Q19739", "WBGene00009059", "species_29438" ] }, "reaction_10571423": { "compartment": "compartment_876", "id": "reaction_10571423", "reactome": "R-CEL-9018768", "name": "RHOU auto-activates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10571420" ], "products": [ "species_29420", "species_10571400" ], "modifiers": [ [ "species_10571420", "catalyst" ] ], "additional_components": [ "Q19739", "WBGene00009059", "species_29420", "Q19739", "WBGene00009059", "species_29438", "Q19739", "WBGene00009059", "species_29420" ] }, "reaction_10571105": { "compartment": "compartment_876", "id": "reaction_10571105", "reactome": "R-CEL-9013147", "name": "RAC1 GDIs block activation of RAC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10570939", "species_10541992" ], "products": [ "species_10571103" ], "modifiers": [], "additional_components": [ "WBGene00004356", "species_29420", "Q03206", "ced-10", "Q20496", "WBGene00004356", "species_29420", "Q03206", "ced-10" ] }, "reaction_10573125": { "compartment": "compartment_876", "id": "reaction_10573125", "reactome": "R-CEL-9691168", "name": "RAC1 translocates to the endoplasmic reticulum membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509457" ], "products": [ "species_10573123" ], "modifiers": [], "additional_components": [ "species_29438", "Q03206", "ced-10", "Q03206", "ced-10", "species_29438" ] }, "reaction_10571067": { "compartment": "compartment_876", "id": "reaction_10571067", "reactome": "R-CEL-9013144", "name": "RAC1 GAPs stimulate RAC1 GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10509457" ], "products": [ "species_29372", "species_10541992" ], "modifiers": [ [ "species_10571064", "catalyst" ] ], "additional_components": [ "species_29438", "Q03206", "ced-10", "species_29420", "Q03206", "ced-10", "P34288", "WBGene00015418", "Q9XVI0", "WBGene00011970", "P46941", "WBGene00008006", "Q20498", "WBGene00009800", "U4PAK0", "WBGene00007064", "Q9XW53", "WBGene00013135", "A0A2K5AU23", "WBGene00021324", "G5EF80", "WBGene00014051", "Q965N4", "WBGene00015267", "Q86NH1", "WBGene00006363", "Q19370", "WBGene00006406" ] }, "reaction_10571101": { "compartment": "compartment_876", "id": "reaction_10571101", "reactome": "R-CEL-9013145", "name": "RAC1 binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10571097", "species_10509457" ], "products": [ "species_10571099" ], "modifiers": [], "additional_components": [ "O44518", "WBGene00001579", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "O01583", "WBGene00006437", "G5EFU0", "WBGene00006443", "G5EDU3", "WBGene00004040", "A0A4V0ILM7", "WBGene00009793", "G5EDP9", "WBGene00000001", "Q94125", "WBGene00000090", "Q18879", "WBGene00000302", "Q94051", "WBGene00000301", "O17772", "WBGene00003980", "Q9BL72", "WBGene00021698", "Q17865", "WBGene00007486", "Q9NAN2", "WBGene00003921", "A5Z2X2", "WBGene00303007", "P55163", "WBGene00001580", "Q9XVK6", "WBGene00006958", "Q10929", "WBGene00015146", "species_29438", "Q03206", "ced-10", "species_29438", "Q03206", "ced-10", "O44518", "WBGene00001579", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "O01583", "WBGene00006437", "G5EFU0", "WBGene00006443", "G5EDU3", "WBGene00004040", "A0A4V0ILM7", "WBGene00009793", "G5EDP9", "WBGene00000001", "Q94125", "WBGene00000090", "Q18879", "WBGene00000302", "Q94051", "WBGene00000301", "O17772", "WBGene00003980", "Q9BL72", "WBGene00021698", "Q17865", "WBGene00007486", "Q9NAN2", "WBGene00003921", "A5Z2X2", "WBGene00303007", "P55163", "WBGene00001580", "Q9XVK6", "WBGene00006958", "Q10929", "WBGene00015146" ] }, "reaction_10571020": { "compartment": "compartment_876", "id": "reaction_10571020", "reactome": "R-CEL-9013143", "name": "RAC1 GEFs activate RAC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10541992" ], "products": [ "species_29420", "species_10509457" ], "modifiers": [ [ "species_10571017", "catalyst" ] ], "additional_components": [ "species_29420", "Q03206", "ced-10", "species_29438", "Q03206", "ced-10", "X5LX76", "WBGene00006450", "Q19572", "WBGene00001674", "O01847", "WBGene00015704", "Q45FX5", "WBGene00006887" ] }, "reaction_10571433": { "compartment": "compartment_876", "id": "reaction_10571433", "reactome": "R-CEL-9018794", "name": "RHOV binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10571429", "species_10571427" ], "products": [ "species_10571431" ], "modifiers": [], "additional_components": [ "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "G5EFU0", "WBGene00006443", "Q19739", "WBGene00009059", "species_29438", "Q19739", "WBGene00009059", "species_29438", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "G5EFU0", "WBGene00006443" ] }, "reaction_10571437": { "compartment": "compartment_876", "id": "reaction_10571437", "reactome": "R-CEL-9018798", "name": "RHOV binds GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10571435" ], "products": [ "species_29420", "species_10571427" ], "modifiers": [], "additional_components": [ "Q19739", "WBGene00009059", "species_29420", "Q19739", "WBGene00009059", "species_29438" ] }, "reaction_10571156": { "compartment": "compartment_876", "id": "reaction_10571156", "reactome": "R-CEL-9013161", "name": "CDC42 GAPs stimulate CDC42 GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10512279" ], "products": [ "species_10571134", "species_29372" ], "modifiers": [ [ "species_10571153", "catalyst" ] ], "additional_components": [ "Q05062", "WBGene00000390", "species_29438", "Q05062", "WBGene00000390", "species_29420", "Q9XW53", "WBGene00013135", "G5EF80", "WBGene00014051", "H2KZV4", "WBGene00017760", "Q23130", "WBGene00012203" ] }, "reaction_10571142": { "compartment": "compartment_876", "id": "reaction_10571142", "reactome": "R-CEL-9013158", "name": "CDC42 GDIs block activation of CDC42", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10571134", "species_10571138" ], "products": [ "species_10571140" ], "modifiers": [], "additional_components": [ "Q05062", "WBGene00000390", "species_29420", "Q20496", "WBGene00004356", "Q18879", "WBGene00000302", "Q94051", "WBGene00000301", "Q20496", "WBGene00004356", "Q18879", "WBGene00000302", "Q94051", "WBGene00000301", "Q05062", "WBGene00000390", "species_29420" ] }, "reaction_10573129": { "compartment": "compartment_876", "id": "reaction_10573129", "reactome": "R-CEL-9692800", "name": "CDC42 translocates to the endoplasmic reticulum membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10512279" ], "products": [ "species_10573127" ], "modifiers": [], "additional_components": [ "Q05062", "WBGene00000390", "species_29438", "Q05062", "WBGene00000390", "species_29438" ] }, "reaction_10571149": { "compartment": "compartment_876", "id": "reaction_10571149", "reactome": "R-CEL-9013159", "name": "CDC42 GEFs activate CDC42", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10571134", "species_29438" ], "products": [ "species_29420", "species_10512279" ], "modifiers": [ [ "species_10571146", "catalyst" ] ], "additional_components": [ "Q05062", "WBGene00000390", "species_29420", "Q05062", "WBGene00000390", "species_29438", "Q19572", "WBGene00001674", "X5LV34", "WBGene00001366", "G5EF62", "WBGene00009337", "Q965J0", "WBGene00019487", "H2KYI7", "WBGene00006496", "G5ECK4", "WBGene00044989" ] }, "reaction_10571217": { "compartment": "compartment_876", "id": "reaction_10571217", "reactome": "R-CEL-9013452", "name": "RHOD:GTP translocates to the endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10571194" ], "products": [ "species_10554702" ], "modifiers": [], "additional_components": [ "Q22038", "WBGene00004357", "species_29438", "Q22038", "WBGene00004357", "species_29438" ] }, "reaction_10573201": { "compartment": "compartment_876", "id": "reaction_10573201", "reactome": "R-CEL-9693243", "name": "RHOD translocates to the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10571194" ], "products": [ "species_10573199" ], "modifiers": [], "additional_components": [ "Q22038", "WBGene00004357", "species_29438", "Q22038", "WBGene00004357", "species_29438" ] }, "reaction_10573187": { "compartment": "compartment_876", "id": "reaction_10573187", "reactome": "R-CEL-9693207", "name": "RHOD translocates to the mitochondrial outer membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10571194" ], "products": [ "species_10573185" ], "modifiers": [], "additional_components": [ "Q22038", "WBGene00004357", "species_29438", "Q22038", "WBGene00004357", "species_29438" ] }, "reaction_10571202": { "compartment": "compartment_876", "id": "reaction_10571202", "reactome": "R-CEL-9013437", "name": "RHOD GAPs stimulate RHOD GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10571194" ], "products": [ "species_29372", "species_10571190" ], "modifiers": [ [ "species_10571199", "catalyst" ] ], "additional_components": [ "Q22038", "WBGene00004357", "species_29438", "Q22038", "WBGene00004357", "species_29420", "Q20498", "WBGene00009800", "O45611", "WBGene00010374", "H2KZV6", "WBGene00020209", "Q23130", "WBGene00012203" ] }, "reaction_10573195": { "compartment": "compartment_17906", "id": "reaction_10573195", "reactome": "R-CEL-9693214", "name": "RHOD binds effectors at the mitochondrial outer membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10573191", "species_10573185" ], "products": [ "species_10573193" ], "modifiers": [], "additional_components": [ "G5EFU0", "WBGene00006443", "Q22038", "WBGene00004357", "species_29438", "Q22038", "WBGene00004357", "species_29438", "G5EFU0", "WBGene00006443" ] }, "reaction_10571197": { "compartment": "compartment_876", "id": "reaction_10571197", "reactome": "R-CEL-9013435", "name": "RHOD auto-activates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10571190" ], "products": [ "species_29420", "species_10571194" ], "modifiers": [ [ "species_10571190", "catalyst" ] ], "additional_components": [ "Q22038", "WBGene00004357", "species_29420", "Q22038", "WBGene00004357", "species_29438", "Q22038", "WBGene00004357", "species_29420" ] }, "reaction_10573181": { "compartment": "compartment_70101", "id": "reaction_10573181", "reactome": "R-CEL-9693198", "name": "RHOD binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10571194", "species_10573177" ], "products": [ "species_10573179" ], "modifiers": [], "additional_components": [ "Q22038", "WBGene00004357", "species_29438", "Q23158", "WBGene00000228", "Q9XUT0", "WBGene00010664", "Q23130", "WBGene00012203", "Q18879", "WBGene00000302", "Q94051", "WBGene00000301", "Q23146", "WBGene00004271", "O02163", "WBGene00020376", "Q7K7J0", "WBGene00001575", "Q9XUB9", "WBGene00012128", "Q20952", "WBGene00000073", "Q9U9K0", "WBGene00000072", "Q7JP75", "WBGene00000872", "Q19479", "WBGene00008848", "Q9U2A6", "WBGene00012980", "B3WFV9", "WBGene00009920", "Q58QG8", "WBGene00019844", "O02495", "WBGene00004897", "H2KY90", "WBGene00015171", "A0A679L8R0", "WBGene00020443", "P34686", "WBGene00000293", "Q21443", "WBGene00003052", "Q23158", "WBGene00000228", "Q9XUT0", "WBGene00010664", "Q23130", "WBGene00012203", "Q18879", "WBGene00000302", "Q94051", "WBGene00000301", "Q23146", "WBGene00004271", "O02163", "WBGene00020376", "Q7K7J0", "WBGene00001575", "Q9XUB9", "WBGene00012128", "Q20952", "WBGene00000073", "Q9U9K0", "WBGene00000072", "Q7JP75", "WBGene00000872", "Q19479", "WBGene00008848", "Q9U2A6", "WBGene00012980", "B3WFV9", "WBGene00009920", "Q58QG8", "WBGene00019844", "O02495", "WBGene00004897", "H2KY90", "WBGene00015171", "A0A679L8R0", "WBGene00020443", "P34686", "WBGene00000293", "Q21443", "WBGene00003052", "Q22038", "WBGene00004357", "species_29438" ] }, "reaction_10571215": { "compartment": "compartment_876", "id": "reaction_10571215", "reactome": "R-CEL-9013438", "name": "RHOD binds effectors at the endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10554702", "species_10571211" ], "products": [ "species_10571213" ], "modifiers": [], "additional_components": [ "Q22038", "WBGene00004357", "species_29438", "Q7JP75", "WBGene00000872", "Q7JP75", "WBGene00000872", "Q22038", "WBGene00004357", "species_29438" ] }, "reaction_10571267": { "compartment": "compartment_70101", "id": "reaction_10571267", "reactome": "R-CEL-9014296", "name": "RAC2 GEFs activate RAC2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10571245" ], "products": [ "species_10509471", "species_29420" ], "modifiers": [ [ "species_10571264", "catalyst" ] ], "additional_components": [ "species_29420", "Q94124", "WBGene00004287", "Q9BL44", "WBGene00022177", "Q03206", "ced-10", "Q94124", "WBGene00004287", "Q9BL44", "WBGene00022177", "Q03206", "ced-10", "species_29438", "O01847", "WBGene00015704", "H2KYI7", "WBGene00006496", "Q45FX5", "WBGene00006887", "G5EEN3", "WBGene00000419" ] }, "reaction_10571251": { "compartment": "compartment_70101", "id": "reaction_10571251", "reactome": "R-CEL-9014293", "name": "RAC2 GDIs block activation of RAC2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10571245", "species_10570939" ], "products": [ "species_10571249" ], "modifiers": [], "additional_components": [ "species_29420", "Q94124", "WBGene00004287", "Q9BL44", "WBGene00022177", "Q03206", "ced-10", "WBGene00004356", "Q20496", "WBGene00004356", "Q94124", "WBGene00004287", "Q9BL44", "WBGene00022177", "Q03206", "ced-10", "species_29420" ] }, "reaction_10571269": { "compartment": "compartment_876", "id": "reaction_10571269", "reactome": "R-CEL-9014420", "name": "RAC2 translocates to the phagocytic vesicle membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509471" ], "products": [ "species_10554742" ], "modifiers": [], "additional_components": [ "Q94124", "WBGene00004287", "Q9BL44", "WBGene00022177", "Q03206", "ced-10", "species_29438", "Q94124", "WBGene00004287", "Q9BL44", "WBGene00022177", "Q03206", "ced-10", "species_29438" ] }, "reaction_10573381": { "compartment": "compartment_876", "id": "reaction_10573381", "reactome": "R-CEL-9714483", "name": "RAC2 translocates to the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509471" ], "products": [ "species_10573379" ], "modifiers": [], "additional_components": [ "Q94124", "WBGene00004287", "Q9BL44", "WBGene00022177", "Q03206", "ced-10", "species_29438", "Q03206", "ced-10", "Q94124", "WBGene00004287", "Q9BL44", "WBGene00022177", "species_29438" ] }, "reaction_10571257": { "compartment": "compartment_70101", "id": "reaction_10571257", "reactome": "R-CEL-9014294", "name": "RAC2 binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509471", "species_10571253" ], "products": [ "species_10571255" ], "modifiers": [], "additional_components": [ "Q94124", "WBGene00004287", "Q9BL44", "WBGene00022177", "Q03206", "ced-10", "species_29438", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "G5EFU0", "WBGene00006443", "G5EDU3", "WBGene00004040", "G5EDP9", "WBGene00000001", "Q94125", "WBGene00000090", "O17772", "WBGene00003980", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "G5EFU0", "WBGene00006443", "G5EDU3", "WBGene00004040", "G5EDP9", "WBGene00000001", "Q94125", "WBGene00000090", "O17772", "WBGene00003980", "Q94124", "WBGene00004287", "Q9BL44", "WBGene00022177", "Q03206", "ced-10", "species_29438" ] }, "reaction_10573369": { "compartment": "compartment_17906", "id": "reaction_10573369", "reactome": "R-CEL-9714477", "name": "RAC2 binds effectors at the mitochondrial outer membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10573348", "species_10573365" ], "products": [ "species_10573367" ], "modifiers": [], "additional_components": [ "Q9BL44", "WBGene00022177", "Q03206", "ced-10", "Q94124", "WBGene00004287", "species_29438", "Q9BL44", "WBGene00022177", "Q03206", "ced-10", "Q94124", "WBGene00004287", "species_29438" ] }, "reaction_10573371": { "compartment": "compartment_876", "id": "reaction_10573371", "reactome": "R-CEL-9714480", "name": "RAC2 translocates to the mitochondrial membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509471" ], "products": [ "species_10573348" ], "modifiers": [], "additional_components": [ "Q94124", "WBGene00004287", "Q9BL44", "WBGene00022177", "Q03206", "ced-10", "species_29438", "Q9BL44", "WBGene00022177", "Q03206", "ced-10", "Q94124", "WBGene00004287", "species_29438" ] }, "reaction_10571262": { "compartment": "compartment_70101", "id": "reaction_10571262", "reactome": "R-CEL-9014295", "name": "RAC2 GAPs stimulate RAC2 GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509471", "species_29356" ], "products": [ "species_29372", "species_10571245" ], "modifiers": [ [ "species_10571259", "catalyst" ] ], "additional_components": [ "Q94124", "WBGene00004287", "Q9BL44", "WBGene00022177", "Q03206", "ced-10", "species_29438", "species_29420", "Q94124", "WBGene00004287", "Q9BL44", "WBGene00022177", "Q03206", "ced-10", "O45611", "WBGene00010374", "H2KZV6", "WBGene00020209", "Q23130", "WBGene00012203" ] }, "reaction_10573170": { "compartment": "compartment_876", "id": "reaction_10573170", "reactome": "R-CEL-9693125", "name": "RHOF binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10573166", "species_10573139" ], "products": [ "species_10573168" ], "modifiers": [], "additional_components": [ "O17905", "WBGene00001490", "Q7JP75", "WBGene00000872", "Q19479", "WBGene00008848", "species_29438", "Q22038", "WBGene00004357", "species_29438", "Q22038", "WBGene00004357", "O17905", "WBGene00001490", "Q7JP75", "WBGene00000872", "Q19479", "WBGene00008848" ] }, "reaction_10573142": { "compartment": "compartment_876", "id": "reaction_10573142", "reactome": "R-CEL-9693111", "name": "RHOF auto-activates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10573137" ], "products": [ "species_29420", "species_10573139" ], "modifiers": [ [ "species_10573137", "catalyst" ] ], "additional_components": [ "species_29420", "Q22038", "WBGene00004357", "species_29438", "Q22038", "WBGene00004357", "species_29420", "Q22038", "WBGene00004357" ] }, "reaction_10573206": { "compartment": "compartment_876", "id": "reaction_10573206", "reactome": "R-CEL-9693282", "name": "RHOF GAPs stimulate RHOF GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10573139" ], "products": [ "species_29372", "species_10573137" ], "modifiers": [ [ "species_10573203", "catalyst" ] ], "additional_components": [ "species_29438", "Q22038", "WBGene00004357", "species_29420", "Q22038", "WBGene00004357", "Q23130", "WBGene00012203" ] }, "reaction_10553794": { "compartment": "compartment_70101", "id": "reaction_10553794", "reactome": "R-CEL-5626507", "name": "IQGAPs bind F-actin, which is inhibited by calmodulin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10523755", "species_10553786" ], "products": [ "species_10553790" ], "modifiers": [ [ "species_10553792", "inhibitor" ] ], "additional_components": [ "P0DM41", "WBGene00000063", "P0DM42", "WBGene00000065", "P10984", "WBGene00000064", "P10986", "WBGene00000066", "species_29358", "species_29438", "Q03206", "ced-10", "Q05062", "WBGene00000390", "O17772", "WBGene00003980", "species_29438", "Q03206", "ced-10", "Q05062", "WBGene00000390", "O17772", "WBGene00003980", "P0DM41", "WBGene00000063", "P0DM42", "WBGene00000065", "P10984", "WBGene00000064", "P10986", "WBGene00000066", "species_29358", "species_74016", "O16305", "WBGene00000552", "P04630", "WBGene00000285", "Q09665", "WBGene00006583", "A0A2C9C3L3", "WBGene00020378", "Q09980", "WBGene00017394", "G5EDZ8", "WBGene00000288", "Q11083", "WBGene00020378", "G5EEG0", "WBGene00000286", "Q18136", "WBGene00006861", "G5EF37", "WBGene00003934", "Q94288", "WBGene00000287", "O02159", "WBGene00020378", "species_29438", "Q03206", "ced-10", "Q05062", "WBGene00000390", "O17772", "WBGene00003980" ] }, "reaction_10553797": { "compartment": "compartment_876", "id": "reaction_10553797", "reactome": "R-CEL-5626549", "name": "IQGAPs bind CALM1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10553786", "species_10515137" ], "products": [ "species_10553792" ], "modifiers": [], "additional_components": [ "species_29438", "Q03206", "ced-10", "Q05062", "WBGene00000390", "O17772", "WBGene00003980", "species_74016", "O16305", "WBGene00000552", "P04630", "WBGene00000285", "Q09665", "WBGene00006583", "A0A2C9C3L3", "WBGene00020378", "Q09980", "WBGene00017394", "G5EDZ8", "WBGene00000288", "Q11083", "WBGene00020378", "G5EEG0", "WBGene00000286", "Q18136", "WBGene00006861", "G5EF37", "WBGene00003934", "Q94288", "WBGene00000287", "O02159", "WBGene00020378", "species_74016", "O16305", "WBGene00000552", "P04630", "WBGene00000285", "Q09665", "WBGene00006583", "A0A2C9C3L3", "WBGene00020378", "Q09980", "WBGene00017394", "G5EDZ8", "WBGene00000288", "Q11083", "WBGene00020378", "G5EEG0", "WBGene00000286", "Q18136", "WBGene00006861", "G5EF37", "WBGene00003934", "Q94288", "WBGene00000287", "O02159", "WBGene00020378", "species_29438", "Q03206", "ced-10", "Q05062", "WBGene00000390", "O17772", "WBGene00003980" ] }, "reaction_10553788": { "compartment": "compartment_70101", "id": "reaction_10553788", "reactome": "R-CEL-5626469", "name": "GTP-bound RAC1 and CDC42 bind IQGAPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10553784", "species_10520664" ], "products": [ "species_10553786" ], "modifiers": [], "additional_components": [ "O17772", "WBGene00003980", "species_29438", "Q03206", "ced-10", "Q05062", "WBGene00000390", "species_29438", "Q03206", "ced-10", "Q05062", "WBGene00000390", "O17772", "WBGene00003980" ] }, "reaction_10553925": { "compartment": "compartment_13949", "id": "reaction_10553925", "reactome": "R-CEL-5627071", "name": "RHOQ positively regulates trafficking of GOPC:CFTR to the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10553905" ], "products": [ "species_10553923" ], "modifiers": [ [ "species_10553905", "catalyst" ] ], "additional_components": [ "Q19625", "WBGene00003412", "Q95QV2", "WBGene00000477", "O18302", "WBGene00014101", "O62422", "WBGene00012532", "Q05062", "WBGene00000390", "species_29438", "O18302", "WBGene00014101", "Q19625", "WBGene00003412", "Q95QV2", "WBGene00000477", "O62422", "WBGene00012532", "Q05062", "WBGene00000390", "species_29438", "Q19625", "WBGene00003412", "Q95QV2", "WBGene00000477", "O18302", "WBGene00014101", "O62422", "WBGene00012532", "Q05062", "WBGene00000390", "species_29438" ] }, "reaction_10553944": { "compartment": "compartment_13949", "id": "reaction_10553944", "reactome": "R-CEL-5627275", "name": "GOPC promotes translocation of CFTR to lysosomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10553892" ], "products": [ "species_10553942" ], "modifiers": [ [ "species_10553892", "catalyst" ] ], "additional_components": [ "Q19625", "WBGene00003412", "Q95QV2", "WBGene00000477", "O18302", "WBGene00014101", "Q95QV2", "WBGene00000477", "Q19625", "WBGene00003412", "O18302", "WBGene00014101", "Q19625", "WBGene00003412", "Q95QV2", "WBGene00000477", "O18302", "WBGene00014101" ] }, "reaction_10554706": { "compartment": "compartment_70101", "id": "reaction_10554706", "reactome": "R-CEL-5666088", "name": "RHOD:GTP recruits DAIPH2-3 to endosomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10554702", "species_10554698" ], "products": [ "species_10554704" ], "modifiers": [], "additional_components": [ "Q22038", "WBGene00004357", "species_29438", "Q7JP75", "WBGene00000872", "Q7JP75", "WBGene00000872", "Q22038", "WBGene00004357", "species_29438" ] }, "reaction_10554612": { "compartment": "compartment_876", "id": "reaction_10554612", "reactome": "R-CEL-5665727", "name": "FMNL2 binds CDC42:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10512279", "species_10554608" ], "products": [ "species_10554610" ], "modifiers": [], "additional_components": [ "Q05062", "WBGene00000390", "species_29438", "P34489", "WBGene00010453", "Q9BL72", "WBGene00021698", "P34489", "WBGene00010453", "Q9BL72", "WBGene00021698", "Q05062", "WBGene00000390", "species_29438" ] }, "reaction_10548325": { "compartment": "compartment_70101", "id": "reaction_10548325", "reactome": "R-CEL-3858495", "name": "DAAM1 recruits GTP-bound RHOA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10548317", "species_10548321" ], "products": [ "species_10548323" ], "modifiers": [], "additional_components": [ "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "D6VPA1", "WBGene00018976", "species_114632", "Q22038", "WBGene00004357", "species_29438", "species_114632", "Q22038", "WBGene00004357", "species_29438", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "D6VPA1", "WBGene00018976" ] }, "reaction_10554694": { "compartment": "compartment_70101", "id": "reaction_10554694", "reactome": "R-CEL-5665989", "name": "DIAPH1 binds RHOA:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10554686", "species_10509488" ], "products": [ "species_10554688" ], "modifiers": [], "additional_components": [ "Q19479", "WBGene00008848", "Q7JP75", "WBGene00000872", "Q22038", "WBGene00004357", "species_29438", "Q22038", "WBGene00004357", "species_29438", "Q19479", "WBGene00008848", "Q7JP75", "WBGene00000872" ] }, "reaction_10554710": { "compartment": "compartment_70101", "id": "reaction_10554710", "reactome": "R-CEL-5666104", "name": "RHOD:GTP:DIAPH2-3 recruits SRC-1 to endosomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10513079", "species_10554704" ], "products": [ "species_10554708" ], "modifiers": [], "additional_components": [ "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q7JP75", "WBGene00000872", "Q22038", "WBGene00004357", "species_29438", "Q7JP75", "WBGene00000872", "Q22038", "WBGene00004357", "species_29438", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635" ] }, "reaction_10554633": { "compartment": "compartment_876", "id": "reaction_10554633", "reactome": "R-CEL-5665802", "name": "SRGAP2 binds RAC1:GTP:FMNL1:profilin:G-actin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10554629", "species_10554624" ], "products": [ "species_10554631" ], "modifiers": [], "additional_components": [ "WBGene00006406", "species_29438", "Q03206", "ced-10", "Q9BL72", "WBGene00021698", "P0DM41", "WBGene00000063", "P0DM42", "WBGene00000065", "P10984", "WBGene00000064", "P10986", "WBGene00000066", "species_29358", "species_29438", "Q03206", "ced-10", "Q9BL72", "WBGene00021698", "P0DM41", "WBGene00000063", "P0DM42", "WBGene00000065", "P10984", "WBGene00000064", "P10986", "WBGene00000066", "species_29358", "Q19370", "WBGene00006406" ] }, "reaction_10548319": { "compartment": "compartment_70101", "id": "reaction_10548319", "reactome": "R-CEL-3858489", "name": "ppDVL binds DAAM1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10548315", "species_10548290" ], "products": [ "species_10548317" ], "modifiers": [], "additional_components": [ "WBGene00018976", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "D6VPA1", "WBGene00018976" ] }, "reaction_10554723": { "compartment": "compartment_876", "id": "reaction_10554723", "reactome": "R-CEL-5666197", "name": "RHOA:GTP:RTKN binds LIN7B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10554719", "species_10519885" ], "products": [ "species_10554721" ], "modifiers": [], "additional_components": [ "Q22038", "WBGene00004357", "species_29438", "Q17777", "WBGene00007409", "WBGene00002996", "Q22038", "WBGene00004357", "species_29438", "Q17777", "WBGene00007409", "A5PEX5", "WBGene00002996" ] }, "reaction_10554732": { "compartment": "compartment_70101", "id": "reaction_10554732", "reactome": "R-CEL-5666216", "name": "RHOA:GTP:RTKN binds TAX1BP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10554719", "species_10554728" ], "products": [ "species_10554730" ], "modifiers": [], "additional_components": [ "Q22038", "WBGene00004357", "species_29438", "Q17777", "WBGene00007409", "WBGene00016678", "Q09506", "WBGene00016678", "Q22038", "WBGene00004357", "species_29438", "Q17777", "WBGene00007409" ] }, "reaction_10559350": { "compartment": "compartment_1222693", "id": "reaction_10559350", "reactome": "R-CEL-6798174", "name": "PIK3C3:PIK3R4 phosphorylates PI to PI3P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1524165" ], "products": [ "species_1629751", "species_29370" ], "modifiers": [ [ "species_10559347", "catalyst" ] ], "additional_components": [ "Q23669", "WBGene00014151", "Q9TXI7", "WBGene00006932" ] }, "reaction_10554803": { "compartment": "compartment_70101", "id": "reaction_10554803", "reactome": "R-CEL-5669158", "name": "NF2 binds PAK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10542001", "species_10520672" ], "products": [ "species_10554801" ], "modifiers": [], "additional_components": [ "WBGene00003593", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "H2KYX3", "WBGene00003593" ] }, "reaction_10542003": { "compartment": "compartment_70101", "id": "reaction_10542003", "reactome": "R-CEL-2029456", "name": "RAC1 and CDC42 activate PAK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10520664", "species_10520672" ], "products": [ "species_10520670", "species_10541994" ], "modifiers": [ [ "species_10542001", "inhibitor" ] ], "additional_components": [ "species_29438", "Q03206", "ced-10", "Q05062", "WBGene00000390", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "species_29438", "Q03206", "ced-10", "Q05062", "WBGene00000390", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "WBGene00003593" ] }, "reaction_10553954": { "compartment": "compartment_70101", "id": "reaction_10553954", "reactome": "R-CEL-5627775", "name": "Autophosphorylation of PAK1,2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10553951", "species_113592" ], "products": [ "species_29370", "species_10520664", "species_10521284" ], "modifiers": [ [ "species_10553951", "catalyst" ] ], "additional_components": [ "species_29438", "Q03206", "ced-10", "Q05062", "WBGene00000390", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "species_29438", "Q03206", "ced-10", "Q05062", "WBGene00000390", "Q17850", "WBGene00003911", "G5EGQ3", "WBGene00003144", "species_29438", "Q03206", "ced-10", "Q05062", "WBGene00000390", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911" ] }, "reaction_10554822": { "compartment": "compartment_70101", "id": "reaction_10554822", "reactome": "R-CEL-5669250", "name": "PAK1 phosphorylates FLNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10554807" ], "products": [ "species_29370", "species_10521268", "species_10554819" ], "modifiers": [ [ "species_10554807", "catalyst" ] ], "additional_components": [ "Q17850", "WBGene00003911", "G5EGQ3", "WBGene00003144", "D0VWL6", "WBGene00016006", "U4PBJ9", "WBGene00022048", "Q17850", "WBGene00003911", "G5EGQ3", "WBGene00003144", "D0VWL6", "WBGene00016006", "U4PBJ9", "WBGene00022048", "Q17850", "WBGene00003911", "G5EGQ3", "WBGene00003144", "D0VWL6", "WBGene00016006", "U4PBJ9", "WBGene00022048" ] }, "reaction_10554809": { "compartment": "compartment_70101", "id": "reaction_10554809", "reactome": "R-CEL-5669240", "name": "FLNA binds PAK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10521268", "species_10554805" ], "products": [ "species_10554807" ], "modifiers": [], "additional_components": [ "Q17850", "WBGene00003911", "G5EGQ3", "WBGene00003144", "D0VWL6", "WBGene00016006", "U4PBJ9", "WBGene00022048", "Q17850", "WBGene00003911", "G5EGQ3", "WBGene00003144", "D0VWL6", "WBGene00016006", "U4PBJ9", "WBGene00022048" ] }, "reaction_10570440": { "compartment": "compartment_70101", "id": "reaction_10570440", "reactome": "R-CEL-8981926", "name": "RAC1 and CDC42 activate PAK3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10520684", "species_10520664" ], "products": [ "species_10553949", "species_10520682" ], "modifiers": [], "additional_components": [ "Q17850", "WBGene00003911", "species_29438", "Q03206", "ced-10", "Q05062", "WBGene00000390", "species_29438", "Q03206", "ced-10", "Q05062", "WBGene00000390", "Q17850", "WBGene00003911", "WBGene00003911" ] }, "reaction_10570442": { "compartment": "compartment_70101", "id": "reaction_10570442", "reactome": "R-CEL-8981931", "name": "RAC1 and CDC42 activate PAK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10520680", "species_10520664" ], "products": [ "species_10553947", "species_10520678" ], "modifiers": [], "additional_components": [ "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "species_29438", "Q03206", "ced-10", "Q05062", "WBGene00000390", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "species_29438", "Q03206", "ced-10", "Q05062", "WBGene00000390", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911" ] }, "reaction_10554783": { "compartment": "compartment_70101", "id": "reaction_10554783", "reactome": "R-CEL-5668932", "name": "PAK2 phosphorylates myosin regulatory light chain (MRLC)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10554760" ], "products": [ "species_10554780", "species_29370" ], "modifiers": [ [ "species_10521278", "catalyst" ] ], "additional_components": [ "Q20641", "WBGene00003776", "G5EBY3", "WBGene00003777", "P19625", "WBGene00003369", "P19626", "WBGene00003370", "Q09510", "WBGene00003372", "Q20238", "WBGene00009585", "Q21201", "WBGene00010554", "Q69Z12", "WBGene00023451", "Q9XVI9", "WBGene00011734", "P53014", "WBGene00003371", "Q20641", "WBGene00003776", "G5EBY3", "WBGene00003777", "Q20238", "WBGene00009585", "Q21201", "WBGene00010554", "Q69Z12", "WBGene00023451", "Q9XVI9", "WBGene00011734", "P53014", "WBGene00003371", "P19625", "WBGene00003369", "P19626", "WBGene00003370", "Q09510", "WBGene00003372", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911" ] }, "reaction_10554799": { "compartment": "compartment_70101", "id": "reaction_10554799", "reactome": "R-CEL-5668947", "name": "PAK1 phosphorylates myosin phosphatase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10554791" ], "products": [ "species_10554796", "species_29370" ], "modifiers": [ [ "species_10521268", "catalyst" ] ], "additional_components": [ "Q27497", "WBGene00001747", "G5ECD7", "WBGene00003196", "Q27497", "WBGene00001747", "G5ECD7", "WBGene00003196", "Q17850", "WBGene00003911", "G5EGQ3", "WBGene00003144" ] }, "reaction_10554832": { "compartment": "compartment_70101", "id": "reaction_10554832", "reactome": "R-CEL-5671737", "name": "p-T774-PKN1 binds CDC25C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10553254", "species_10509856" ], "products": [ "species_10554830" ], "modifiers": [], "additional_components": [ "WBGene00009793", "WBGene00000389", "Q21762", "WBGene00000389", "A0A4V0ILM7", "WBGene00009793" ] }, "reaction_10507073": { "compartment": "compartment_70101", "id": "reaction_10507073", "reactome": "R-CEL-75016", "name": "Association of p-S216-CDC25C with 14-3-3 proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10507069", "species_10507019" ], "products": [ "species_10507071" ], "modifiers": [], "additional_components": [ "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "WBGene00000389", "Q21762", "WBGene00000389", "P41932", "WBGene00003920", "Q20655", "WBGene00001502" ] }, "reaction_10554835": { "compartment": "compartment_70101", "id": "reaction_10554835", "reactome": "R-CEL-5671749", "name": "p-T774-PKN1 phosphorylates CDC25C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10554830", "species_113592" ], "products": [ "species_10507019", "species_29370", "species_10553254" ], "modifiers": [ [ "species_10554830", "catalyst" ] ], "additional_components": [ "Q21762", "WBGene00000389", "A0A4V0ILM7", "WBGene00009793", "WBGene00000389", "WBGene00009793", "Q21762", "WBGene00000389", "A0A4V0ILM7", "WBGene00009793" ] }, "reaction_10554850": { "compartment": "compartment_70101", "id": "reaction_10554850", "reactome": "R-CEL-5671772", "name": "p-T38-PPP1R14A binds MLCP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10554843", "species_10554791" ], "products": [ "species_10554848" ], "modifiers": [], "additional_components": [ "WBGene00010109", "Q27497", "WBGene00001747", "G5ECD7", "WBGene00003196", "Q27497", "WBGene00001747", "G5ECD7", "WBGene00003196", "Q7YX00", "WBGene00010109" ] }, "reaction_10553239": { "compartment": "compartment_876", "id": "reaction_10553239", "reactome": "R-CEL-5623622", "name": "RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10553227", "species_10553235" ], "products": [ "species_10553237" ], "modifiers": [], "additional_components": [ "WBGene00009793", "Q22038", "WBGene00004357", "species_29438", "Q22038", "WBGene00004357", "species_29438", "A0A4V0ILM7", "WBGene00009793" ] }, "reaction_10553243": { "compartment": "compartment_876", "id": "reaction_10553243", "reactome": "R-CEL-5623632", "name": "RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10553237", "species_10508530" ], "products": [ "species_10553241" ], "modifiers": [], "additional_components": [ "Q22038", "WBGene00004357", "species_29438", "A0A4V0ILM7", "WBGene00009793", "Q9UA62", "WBGene00021022", "species_179838", "Q9UA62", "WBGene00021022", "species_179838", "Q22038", "WBGene00004357", "species_29438", "A0A4V0ILM7", "WBGene00009793" ] }, "reaction_10553263": { "compartment": "compartment_70101", "id": "reaction_10553263", "reactome": "R-CEL-5623667", "name": "PDPK1 phosphorylates PKN1,2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10553241" ], "products": [ "species_29370", "species_10553254", "species_10553235", "species_10508530" ], "modifiers": [ [ "species_10553241", "catalyst" ] ], "additional_components": [ "Q9UA62", "WBGene00021022", "species_179838", "Q22038", "WBGene00004357", "species_29438", "A0A4V0ILM7", "WBGene00009793", "WBGene00009793", "Q22038", "WBGene00004357", "species_29438", "Q9UA62", "WBGene00021022", "species_179838", "Q9UA62", "WBGene00021022", "species_179838", "Q22038", "WBGene00004357", "species_29438", "A0A4V0ILM7", "WBGene00009793" ] }, "reaction_10553760": { "compartment": "compartment_7660", "id": "reaction_10553760", "reactome": "R-CEL-5625797", "name": "KDM4C demethylates Me3K-10-H3 associated with KLK2 and KLK3 promoters", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113671", "species_113685", "species_10553745" ], "products": [ "species_10553757", "species_29478", "species_10549605", "species_159942", "species_159939" ], "modifiers": [ [ "species_10553745", "catalyst" ] ], "additional_components": [ "Q9U297", "WBGene00012982", "A0A4V0ILM7", "WBGene00009793", "species_469662", "CHEBI:29117", "species_193057", "species_193079", "P62784", "WBGene00001875", "K7ZUH9", "WBGene00001914", "Q10453", "WBGene00001945", "A0A4V0ILM7", "WBGene00009793", "species_469662", "CHEBI:29117", "species_193057", "species_193079", "P62784", "WBGene00001875", "Q10453", "WBGene00001945", "K7ZUH9", "WBGene00001914", "WBGene00012982", "Q9U297", "WBGene00012982", "A0A4V0ILM7", "WBGene00009793", "species_469662", "CHEBI:29117", "species_193057", "species_193079", "P62784", "WBGene00001875", "K7ZUH9", "WBGene00001914", "Q10453", "WBGene00001945" ] }, "reaction_10553747": { "compartment": "compartment_7660", "id": "reaction_10553747", "reactome": "R-CEL-5625796", "name": "Demethylase KDM4C binds KLK2 and KLK3 promoters", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10553740", "species_10549605" ], "products": [ "species_10553745" ], "modifiers": [], "additional_components": [ "A0A4V0ILM7", "WBGene00009793", "species_469662", "CHEBI:29117", "species_193057", "species_193079", "P62784", "WBGene00001875", "K7ZUH9", "WBGene00001914", "Q10453", "WBGene00001945", "WBGene00012982", "Q9U297", "WBGene00012982", "A0A4V0ILM7", "WBGene00009793", "species_469662", "CHEBI:29117", "species_193057", "species_193079", "P62784", "WBGene00001875", "K7ZUH9", "WBGene00001914", "Q10453", "WBGene00001945" ] }, "reaction_10553743": { "compartment": "compartment_7660", "id": "reaction_10553743", "reactome": "R-CEL-5625784", "name": "PKN1 phosphorylates histone 3 of nucleosomes associate with KLK2 and KLK3 promoters", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10553726", "species_29358" ], "products": [ "species_113582", "species_10553740" ], "modifiers": [ [ "species_10553726", "catalyst" ] ], "additional_components": [ "A0A4V0ILM7", "WBGene00009793", "species_469662", "CHEBI:29117", "species_193057", "species_193079", "P62784", "WBGene00001875", "Q10453", "WBGene00001945", "K7ZUH9", "WBGene00001914", "A0A4V0ILM7", "WBGene00009793", "species_469662", "CHEBI:29117", "species_193057", "species_193079", "P62784", "WBGene00001875", "K7ZUH9", "WBGene00001914", "Q10453", "WBGene00001945", "A0A4V0ILM7", "WBGene00009793", "species_469662", "CHEBI:29117", "species_193057", "species_193079", "P62784", "WBGene00001875", "Q10453", "WBGene00001945", "K7ZUH9", "WBGene00001914" ] }, "reaction_10554846": { "compartment": "compartment_70101", "id": "reaction_10554846", "reactome": "R-CEL-5671763", "name": "p-T774-PKN1 phosphorylates PPP1R14A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10554840" ], "products": [ "species_10554843", "species_29370" ], "modifiers": [ [ "species_10553254", "catalyst" ] ], "additional_components": [ "WBGene00010109", "WBGene00010109", "WBGene00009793" ] }, "reaction_10542752": { "compartment": "compartment_876", "id": "reaction_10542752", "reactome": "R-CEL-2130194", "name": "ABL phosphorylates WAVEs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10542749", "species_113592" ], "products": [ "species_29370", "species_10542068" ], "modifiers": [ [ "species_10519289", "catalyst" ] ], "additional_components": [ "species_29438", "Q03206", "ced-10", "A5Z2X2", "WBGene00303007", "O44518", "WBGene00001579", "P55163", "WBGene00001580", "Q9XVK6", "WBGene00006958", "Q10929", "WBGene00015146", "species_179838", "species_29438", "Q03206", "ced-10", "A5Z2X2", "WBGene00303007", "O44518", "WBGene00001579", "P55163", "WBGene00001580", "Q10929", "WBGene00015146", "Q9XVK6", "WBGene00006958", "species_179838", "WBGene00000018" ] }, "reaction_10542112": { "compartment": "compartment_70101", "id": "reaction_10542112", "reactome": "R-CEL-2029473", "name": "Branching and elongation of mother and daughter filaments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10542110", "species_10515381" ], "products": [ "species_10537825" ], "modifiers": [], "additional_components": [ "P0DM41", "WBGene00000063", "P0DM42", "WBGene00000065", "P10984", "WBGene00000064", "P10986", "WBGene00000066", "species_29358", "species_113582", "P58798", "WBGene00000204", "A0A3P6PCS5", "WBGene00000201", "Q9N4I0", "WBGene00000199", "Q8WTM6", "WBGene00021170", "P53489", "WBGene00000200", "Q9XWV3", "WBGene00000203", "O61861", "WBGene00000205", "P91167", "WBGene00016729", "P0DM41", "WBGene00000063", "P0DM42", "WBGene00000065", "P10984", "WBGene00000064", "P10986", "WBGene00000066", "species_29358", "P0DM41", "WBGene00000063", "P0DM42", "WBGene00000065", "P10984", "WBGene00000064", "P10986", "WBGene00000066", "species_29358", "P58798", "WBGene00000204", "A0A3P6PCS5", "WBGene00000201", "Q9N4I0", "WBGene00000199", "Q8WTM6", "WBGene00021170", "P53489", "WBGene00000200", "Q9XWV3", "WBGene00000203", "O61861", "WBGene00000205", "P91167", "WBGene00016729" ] }, "reaction_10542085": { "compartment": "compartment_70101", "id": "reaction_10542085", "reactome": "R-CEL-2029469", "name": "p-ERK phosphorylates WAVEs and ABI", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10542068" ], "products": [ "species_29370", "species_10542054" ], "modifiers": [ [ "species_10542082", "catalyst" ] ], "additional_components": [ "species_29438", "Q03206", "ced-10", "A5Z2X2", "WBGene00303007", "O44518", "WBGene00001579", "P55163", "WBGene00001580", "Q10929", "WBGene00015146", "Q9XVK6", "WBGene00006958", "species_179838", "species_29438", "Q03206", "ced-10", "A5Z2X2", "WBGene00303007", "O44518", "WBGene00001579", "P55163", "WBGene00001580", "Q9XVK6", "WBGene00006958", "Q10929", "WBGene00015146", "species_179838", "P39745", "WBGene00003401" ] }, "reaction_10543483": { "compartment": "compartment_70101", "id": "reaction_10543483", "reactome": "R-CEL-2197690", "name": "Detachment of WASP/WAVE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10542074" ], "products": [ "species_10542110", "species_10542070" ], "modifiers": [], "additional_components": [ "P0DM41", "WBGene00000063", "P0DM42", "WBGene00000065", "P10984", "WBGene00000064", "P10986", "WBGene00000066", "species_29358", "species_29438", "Q03206", "ced-10", "A5Z2X2", "WBGene00303007", "O44518", "WBGene00001579", "P55163", "WBGene00001580", "Q10929", "WBGene00015146", "Q9XVK6", "WBGene00006958", "species_179838", "P58798", "WBGene00000204", "A0A3P6PCS5", "WBGene00000201", "Q9N4I0", "WBGene00000199", "Q8WTM6", "WBGene00021170", "P53489", "WBGene00000200", "Q9XWV3", "WBGene00000203", "O61861", "WBGene00000205", "P91167", "WBGene00016729", "P0DM41", "WBGene00000063", "P0DM42", "WBGene00000065", "P10984", "WBGene00000064", "P10986", "WBGene00000066", "species_29358", "species_113582", "P58798", "WBGene00000204", "A0A3P6PCS5", "WBGene00000201", "Q9N4I0", "WBGene00000199", "Q8WTM6", "WBGene00021170", "P53489", "WBGene00000200", "Q9XWV3", "WBGene00000203", "O61861", "WBGene00000205", "P91167", "WBGene00016729", "species_29438", "Q03206", "ced-10", "A5Z2X2", "WBGene00303007", "O44518", "WBGene00001579", "P55163", "WBGene00001580", "Q10929", "WBGene00015146", "Q9XVK6", "WBGene00006958", "species_179838" ] }, "reaction_10542076": { "compartment": "compartment_70101", "id": "reaction_10542076", "reactome": "R-CEL-2029466", "name": "(WASPs, WAVE):G-actin:ARP2/3 binds F-actin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10523755", "species_10542072" ], "products": [ "species_10542074" ], "modifiers": [], "additional_components": [ "P0DM41", "WBGene00000063", "P0DM42", "WBGene00000065", "P10984", "WBGene00000064", "P10986", "WBGene00000066", "species_29358", "P0DM41", "WBGene00000063", "P0DM42", "WBGene00000065", "P10984", "WBGene00000064", "P10986", "WBGene00000066", "species_29358", "species_29438", "Q03206", "ced-10", "A5Z2X2", "WBGene00303007", "O44518", "WBGene00001579", "P55163", "WBGene00001580", "Q10929", "WBGene00015146", "Q9XVK6", "WBGene00006958", "species_179838", "P58798", "WBGene00000204", "A0A3P6PCS5", "WBGene00000201", "Q9N4I0", "WBGene00000199", "Q8WTM6", "WBGene00021170", "P53489", "WBGene00000200", "Q9XWV3", "WBGene00000203", "O61861", "WBGene00000205", "P91167", "WBGene00016729", "P0DM41", "WBGene00000063", "P0DM42", "WBGene00000065", "P10984", "WBGene00000064", "P10986", "WBGene00000066", "species_29358", "species_29438", "Q03206", "ced-10", "A5Z2X2", "WBGene00303007", "O44518", "WBGene00001579", "P55163", "WBGene00001580", "Q10929", "WBGene00015146", "Q9XVK6", "WBGene00006958", "species_179838", "P58798", "WBGene00000204", "A0A3P6PCS5", "WBGene00000201", "Q9N4I0", "WBGene00000199", "Q8WTM6", "WBGene00021170", "P53489", "WBGene00000200", "Q9XWV3", "WBGene00000203", "O61861", "WBGene00000205", "P91167", "WBGene00016729" ] }, "reaction_10571243": { "compartment": "compartment_984", "id": "reaction_10571243", "reactome": "R-CEL-9014052", "name": "TXLNA (IL14) binds syntaxin3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10525375", "species_10571239" ], "products": [ "species_10571241" ], "modifiers": [], "additional_components": [ "WBGene00011917", "Q20024", "WBGene00006371", "Q20574", "WBGene00006372", "O16000", "WBGene00006798", "Q20024", "WBGene00006371", "Q20574", "WBGene00006372", "O16000", "WBGene00006798", "Q22666", "WBGene00011917" ] }, "reaction_10525389": { "compartment": "compartment_984", "id": "reaction_10525389", "reactome": "R-CEL-449117", "name": "TXLNA (IL14) binds syntaxin1A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10525375", "species_10516749" ], "products": [ "species_10525377" ], "modifiers": [ [ "species_10525387", "inhibitor" ] ], "additional_components": [ "WBGene00011917", "WBGene00006798", "O16000", "WBGene00006798", "Q22666", "WBGene00011917", "G5EEN8", "WBGene00006454", "A5PEW5", "WBGene00004364", "O44412", "WBGene00020298", "P34815", "WBGene00006757", "O16000", "WBGene00006798" ] }, "reaction_10528533": { "compartment": "compartment_70101", "id": "reaction_10528533", "reactome": "R-CEL-912734", "name": "CBL:CRKL binds RAPGEF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10528524", "species_10528529" ], "products": [ "species_10528531" ], "modifiers": [], "additional_components": [ "Q19019", "WBGene00004829", "Q9NHC3", "WBGene00000416", "Q95XA9", "WBGene00021238", "WBGene00021320", "H2KZX7", "WBGene00021320", "Q19019", "WBGene00004829", "Q9NHC3", "WBGene00000416", "Q95XA9", "WBGene00021238" ] }, "reaction_10528518": { "compartment": "compartment_70101", "id": "reaction_10528518", "reactome": "R-CEL-912627", "name": "CBL ubiquitinates PI3K", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10528462", "species_10528505" ], "products": [ "species_10528516" ], "modifiers": [], "additional_components": [ "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "P29355", "WBGene00004774", "G5EDP9", "WBGene00000001", "Q94125", "WBGene00000090", "Q19019", "WBGene00004829", "P37165", "WBGene00006725", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "Q94125", "WBGene00000090", "G5EDP9", "WBGene00000001", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "P29355", "WBGene00004774", "Q19019", "WBGene00004829" ] }, "reaction_10528535": { "compartment": "compartment_70101", "id": "reaction_10528535", "reactome": "R-CEL-912790", "name": "CBL binds CRK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10520269", "species_10528460" ], "products": [ "species_10528524" ], "modifiers": [], "additional_components": [ "Q9NHC3", "WBGene00000416", "Q95XA9", "WBGene00021238", "WBGene00004829", "Q19019", "WBGene00004829", "Q9NHC3", "WBGene00000416", "Q95XA9", "WBGene00021238" ] }, "reaction_10528266": { "compartment": "compartment_70101", "id": "reaction_10528266", "reactome": "R-CEL-879917", "name": "CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10506892", "species_10512267", "species_10506871", "species_10528262" ], "products": [ "species_10528264" ], "modifiers": [], "additional_components": [ "G5EDP9", "WBGene00000001", "Q94125", "WBGene00000090", "WBGene00004829", "WBGene00004774", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "P29355", "WBGene00004774", "Q19019", "WBGene00004829", "G5EDP9", "WBGene00000001", "Q94125", "WBGene00000090" ] }, "reaction_10528522": { "compartment": "compartment_70101", "id": "reaction_10528522", "reactome": "R-CEL-912727", "name": "CBL binds VAV", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10528460", "species_10516075" ], "products": [ "species_10528520" ], "modifiers": [], "additional_components": [ "WBGene00004829", "WBGene00006887", "Q45FX5", "WBGene00006887", "Q19019", "WBGene00004829" ] }, "reaction_10531907": { "compartment": "compartment_70101", "id": "reaction_10531907", "reactome": "R-CEL-1112587", "name": "STAT1 and STAT3 dimers translocate to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10531891" ], "products": [ "species_10531905" ], "modifiers": [], "additional_components": [ "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111" ] }, "reaction_10531893": { "compartment": "compartment_70101", "id": "reaction_10531893", "reactome": "R-CEL-1112538", "name": "Phosphorylated STAT1, STAT3 form dimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10531885" ], "products": [ "species_10531891" ], "modifiers": [], "additional_components": [ "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111" ] }, "reaction_10573100": { "compartment": "compartment_984", "id": "reaction_10573100", "reactome": "R-CEL-9681294", "name": "IL6R binds IL6R inhibitors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10573096", "species_9715042" ], "products": [ "species_10573098" ], "modifiers": [], "additional_components": [ "WBGene00002915", "Q9UB28", "WBGene00002915" ] }, "reaction_10558097": { "compartment": "compartment_70101", "id": "reaction_10558097", "reactome": "R-CEL-6784765", "name": "p-Y705-STAT3 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10531883" ], "products": [ "species_10531887" ], "modifiers": [], "additional_components": [ "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111" ] }, "reaction_10558095": { "compartment": "compartment_70101", "id": "reaction_10558095", "reactome": "R-CEL-6784763", "name": "p-Y705-STAT3 dimer translocates from cytosol to nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10531887" ], "products": [ "species_10531903" ], "modifiers": [], "additional_components": [ "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111" ] }, "reaction_10570566": { "compartment": "compartment_70101", "id": "reaction_10570566", "reactome": "R-CEL-8985943", "name": "p-Y701-STAT1 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10570562" ], "products": [ "species_10570564" ], "modifiers": [], "additional_components": [ "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251" ] }, "reaction_10570584": { "compartment": "compartment_70101", "id": "reaction_10570584", "reactome": "R-CEL-8985981", "name": "p-Y701-STAT1:p-Y705-STAT3 translocates from the cytosol to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10570572" ], "products": [ "species_10570582" ], "modifiers": [], "additional_components": [ "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251" ] }, "reaction_10570570": { "compartment": "compartment_70101", "id": "reaction_10570570", "reactome": "R-CEL-8985950", "name": "p-Y649-STAT5A, p-STAT5B dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10570515" ], "products": [ "species_10570568" ], "modifiers": [], "additional_components": [] }, "reaction_10570574": { "compartment": "compartment_70101", "id": "reaction_10570574", "reactome": "R-CEL-8985966", "name": "p-Y701-STAT1 binds p-Y705-STAT3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10570521", "species_10570562" ], "products": [ "species_10570572" ], "modifiers": [], "additional_components": [ "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251" ] }, "reaction_10570611": { "compartment": "compartment_70101", "id": "reaction_10570611", "reactome": "R-CEL-8987007", "name": "p-STAT1 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10569000" ], "products": [ "species_10570609" ], "modifiers": [], "additional_components": [ "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111" ] }, "reaction_10570643": { "compartment": "compartment_70101", "id": "reaction_10570643", "reactome": "R-CEL-8987218", "name": "p-STAT1 dimer translocates from the cytosol to the nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10570609" ], "products": [ "species_10570641" ], "modifiers": [], "additional_components": [ "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111" ] }, "reaction_10570629": { "compartment": "compartment_70101", "id": "reaction_10570629", "reactome": "R-CEL-8987052", "name": "p-STAT3 dimer translocates from cytosol to nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10570619" ], "products": [ "species_10570627" ], "modifiers": [], "additional_components": [ "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111" ] }, "reaction_10570633": { "compartment": "compartment_70101", "id": "reaction_10570633", "reactome": "R-CEL-8987214", "name": "p-STAT3 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10570617" ], "products": [ "species_10570619" ], "modifiers": [], "additional_components": [ "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111" ] }, "reaction_10558321": { "compartment": "compartment_70101", "id": "reaction_10558321", "reactome": "R-CEL-6788622", "name": "p-Y-STATs dimerize", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10558317" ], "products": [ "species_10558319" ], "modifiers": [], "additional_components": [ "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111" ] }, "reaction_10558499": { "compartment": "compartment_17957", "id": "reaction_10558499", "reactome": "R-CEL-6790038", "name": "Expression of HSP90B1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [], "products": [ "species_10558497" ], "modifiers": [ [ "species_10531903", "catalyst" ] ], "additional_components": [ "WBGene00011480", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111" ] }, "reaction_10558325": { "compartment": "compartment_70101", "id": "reaction_10558325", "reactome": "R-CEL-6788623", "name": "p-Y-STATs translocate to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10558319" ], "products": [ "species_10558323" ], "modifiers": [], "additional_components": [ "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111" ] }, "reaction_10558148": { "compartment": "compartment_70101", "id": "reaction_10558148", "reactome": "R-CEL-6786097", "name": "p-Y705-STAT3, p-Y641-STAT6 dimerise", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10558142" ], "products": [ "species_10558146" ], "modifiers": [], "additional_components": [ "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111" ] }, "reaction_10558206": { "compartment": "compartment_70101", "id": "reaction_10558206", "reactome": "R-CEL-6786293", "name": "p-Y705-STAT3 dimer, p-Y641-STAT6 dimer translocate to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10558146" ], "products": [ "species_10558204" ], "modifiers": [], "additional_components": [ "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111" ] }, "reaction_10570774": { "compartment": "compartment_70101", "id": "reaction_10570774", "reactome": "R-CEL-9009072", "name": "STAT3 phosphorylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10519913" ], "products": [ "species_29370", "species_10570521" ], "modifiers": [], "additional_components": [ "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9NAD6", "WBGene00013111" ] }, "reaction_10526186": { "compartment": "compartment_70101", "id": "reaction_10526186", "reactome": "R-CEL-451418", "name": "Pellino ubiquitinates IRAK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10526177" ], "products": [ "species_10526183" ], "modifiers": [ [ "species_10526177", "catalyst" ] ], "additional_components": [ "Q22967", "WBGene00017766", "Q95XX0", "WBGene00006708", "O45495", "WBGene00006730", "P37165", "WBGene00006725", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "Q22967", "WBGene00017766", "Q95XX0", "WBGene00006708", "O45495", "WBGene00006730", "Q22967", "WBGene00017766", "Q95XX0", "WBGene00006708", "O45495", "WBGene00006730", "P37165", "WBGene00006725", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727" ] }, "reaction_10525239": { "compartment": "compartment_70101", "id": "reaction_10525239", "reactome": "R-CEL-448673", "name": "Formation of caspase-1 p10/p20 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10525229", "species_10525235" ], "products": [ "species_10525237" ], "modifiers": [], "additional_components": [ "G5EBM1", "WBGene00000819", "P42573", "WBGene00000417", "P42573", "WBGene00000417", "G5EBM1", "WBGene00000819", "P42573", "WBGene00000417", "G5EBM1", "WBGene00000819" ] }, "reaction_10525261": { "compartment": "compartment_70101", "id": "reaction_10525261", "reactome": "R-CEL-448702", "name": "Caspase-1 active tetramer formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10525237" ], "products": [ "species_10525259" ], "modifiers": [], "additional_components": [ "P42573", "WBGene00000417", "G5EBM1", "WBGene00000819", "P42573", "WBGene00000417", "G5EBM1", "WBGene00000819" ] }, "reaction_10570684": { "compartment": "compartment_984", "id": "reaction_10570684", "reactome": "R-CEL-9008043", "name": "MAPK8 phosphorylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10510931" ], "products": [ "species_29370", "species_10510951" ], "modifiers": [], "additional_components": [ "WBGene00002178", "WBGene00002178" ] }, "reaction_10533055": { "compartment": "compartment_984", "id": "reaction_10533055", "reactome": "R-CEL-1362465", "name": "GHBP binds GHR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10530700", "species_10533051" ], "products": [ "species_10533053" ], "modifiers": [], "additional_components": [ "WBGene00002915", "WBGene00002915", "Q9UB28", "WBGene00002915" ] }, "reaction_10543479": { "compartment": "compartment_70101", "id": "reaction_10543479", "reactome": "R-CEL-2187401", "name": "MTMR4 dephosphorylates SMAD2/3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10543476" ], "products": [ "species_29372", "species_10543474", "species_10511457" ], "modifiers": [ [ "species_10543476", "catalyst" ] ], "additional_components": [ "Q22712", "WBGene00003476", "Q21733", "WBGene00000904", "WBGene00003476", "WBGene00000904", "Q22712", "WBGene00003476", "Q21733", "WBGene00000904" ] }, "reaction_10543464": { "compartment": "compartment_70101", "id": "reaction_10543464", "reactome": "R-CEL-2187368", "name": "STUB1 (CHIP) ubiquitinates SMAD3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502375", "species_10543459" ], "products": [ "species_10543461", "species_10530864" ], "modifiers": [ [ "species_10543459", "catalyst" ] ], "additional_components": [ "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "G5ECY6", "WBGene00000500", "Q21733", "WBGene00000904", "Q21733", "WBGene00000904", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "WBGene00000500", "G5ECY6", "WBGene00000500", "Q21733", "WBGene00000904" ] }, "reaction_10543481": { "compartment": "compartment_70101", "id": "reaction_10543481", "reactome": "R-CEL-2187405", "name": "MTMR4 binds phosphorylated SMAD2/3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10511411", "species_10543474" ], "products": [ "species_10543476" ], "modifiers": [], "additional_components": [ "WBGene00000904", "WBGene00003476", "Q22712", "WBGene00003476", "Q21733", "WBGene00000904" ] }, "reaction_10543466": { "compartment": "compartment_70101", "id": "reaction_10543466", "reactome": "R-CEL-2187375", "name": "SMAD3 binds STUB1 (CHIP)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10511459", "species_10530864" ], "products": [ "species_10543459" ], "modifiers": [], "additional_components": [ "WBGene00000904", "WBGene00000500", "G5ECY6", "WBGene00000500", "Q21733", "WBGene00000904" ] }, "reaction_10543468": { "compartment": "compartment_70101", "id": "reaction_10543468", "reactome": "R-CEL-2187382", "name": "Degradation of ubiquitinated SMAD3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10543461" ], "products": [], "modifiers": [], "additional_components": [ "Q21733", "WBGene00000904", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727" ] }, "reaction_10543389": { "compartment": "compartment_70101", "id": "reaction_10543389", "reactome": "R-CEL-2176452", "name": "Degradation of ubiquitinated SMAD2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10543387" ], "products": [], "modifiers": [], "additional_components": [ "Q21733", "WBGene00000904", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727" ] }, "reaction_10543310": { "compartment": "compartment_876", "id": "reaction_10543310", "reactome": "R-CEL-2169046", "name": "Degradation of TGF-beta receptor complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10543308" ], "products": [], "modifiers": [], "additional_components": [ "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "P20792", "WBGene00000897", "G5EBY8", "WBGene00006852", "G5EEL5", "WBGene00000936", "G5EDS9", "WBGene00006445" ] }, "reaction_10512054": { "compartment": "compartment_17963", "id": "reaction_10512054", "reactome": "R-CEL-177107", "name": "Secretion and activation of the latent large complex of TGF-beta-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10511397" ], "products": [ "species_10511431" ], "modifiers": [], "additional_components": [ "G5EEL5", "WBGene00000936", "G5EBY8", "WBGene00006852", "G5EBY8", "WBGene00006852", "G5EEL5", "WBGene00000936" ] }, "reaction_10511399": { "compartment": "compartment_20699", "id": "reaction_10511399", "reactome": "R-CEL-170844", "name": "Latent TGF-beta-1 is cleaved by furin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10511389" ], "products": [ "species_10511397" ], "modifiers": [ [ "species_10510315", "catalyst" ] ], "additional_components": [ "G5EBY8", "WBGene00006852", "G5EEL5", "WBGene00000936", "G5EEL5", "WBGene00000936", "G5EBY8", "WBGene00006852", "WBGene00002232" ] }, "reaction_10511464": { "compartment": "compartment_171062", "id": "reaction_10511464", "reactome": "R-CEL-170868", "name": "Activated type I receptor phosphorylates SMAD2/3 directly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10511461" ], "products": [ "species_10511451", "species_29370" ], "modifiers": [ [ "species_10511461", "catalyst" ] ], "additional_components": [ "Q21733", "WBGene00000904", "P20792", "WBGene00000897", "G5EBY8", "WBGene00006852", "G5EEL5", "WBGene00000936", "H2KZI9", "WBGene00000101", "Q21733", "WBGene00000904", "P20792", "WBGene00000897", "G5EBY8", "WBGene00006852", "G5EEL5", "WBGene00000936", "H2KZI9", "WBGene00000101", "Q21733", "WBGene00000904", "P20792", "WBGene00000897", "G5EBY8", "WBGene00006852", "G5EEL5", "WBGene00000936", "H2KZI9", "WBGene00000101" ] }, "reaction_10511419": { "compartment": "compartment_70101", "id": "reaction_10511419", "reactome": "R-CEL-170847", "name": "Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10511404", "species_10511411" ], "products": [ "species_10511417" ], "modifiers": [], "additional_components": [ "WBGene00004858", "WBGene00000904", "Q21733", "WBGene00000904", "P45897", "WBGene00004858" ] }, "reaction_10511455": { "compartment": "compartment_17941", "id": "reaction_10511455", "reactome": "R-CEL-170850", "name": "Phosphorylated SMAD2/3 dissociates from TGFBR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10511451" ], "products": [ "species_10511453", "species_10511411" ], "modifiers": [], "additional_components": [ "Q21733", "WBGene00000904", "P20792", "WBGene00000897", "G5EBY8", "WBGene00006852", "G5EEL5", "WBGene00000936", "H2KZI9", "WBGene00000101", "P20792", "WBGene00000897", "G5EBY8", "WBGene00006852", "G5EEL5", "WBGene00000936", "H2KZI9", "WBGene00000101", "WBGene00000904" ] }, "reaction_10511520": { "compartment": "compartment_70101", "id": "reaction_10511520", "reactome": "R-CEL-173488", "name": "The SMAD2/3:SMAD4 complex transfers to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10511417" ], "products": [ "species_10511518" ], "modifiers": [], "additional_components": [ "Q21733", "WBGene00000904", "P45897", "WBGene00004858", "P45897", "WBGene00004858", "Q21733", "WBGene00000904" ] }, "reaction_10543457": { "compartment": "compartment_7660", "id": "reaction_10543457", "reactome": "R-CEL-2187309", "name": "SMAD2/3:SMAD4 heterotrimer binds SP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10511518", "species_10543453" ], "products": [ "species_10543455" ], "modifiers": [], "additional_components": [ "P45897", "WBGene00004858", "Q21733", "WBGene00000904", "WBGene00012735", "Q9XW26", "WBGene00012735", "P45897", "WBGene00004858", "Q21733", "WBGene00000904" ] }, "reaction_10542739": { "compartment": "compartment_7660", "id": "reaction_10542739", "reactome": "R-CEL-2127257", "name": "SMAD2/3:SMAD4 heterotrimer forms a complex with RBL1, E2F4/5 and DP1/2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10511518", "species_10532108" ], "products": [ "species_10542737" ], "modifiers": [], "additional_components": [ "P45897", "WBGene00004858", "Q21733", "WBGene00000904", "G5EF11", "WBGene00001161", "G5EDT1", "WBGene00003020", "Q22703", "WBGene00001061", "G5EF11", "WBGene00001161", "G5EDT1", "WBGene00003020", "Q22703", "WBGene00001061", "P45897", "WBGene00004858", "Q21733", "WBGene00000904" ] }, "reaction_10543448": { "compartment": "compartment_7660", "id": "reaction_10543448", "reactome": "R-CEL-2186780", "name": "Degradation of Ub-SMAD7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10543446" ], "products": [], "modifiers": [], "additional_components": [ "G5EDS9", "WBGene00006445", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725" ] }, "reaction_10542699": { "compartment": "compartment_70101", "id": "reaction_10542699", "reactome": "R-CEL-2106579", "name": "WWTR1:SMAD translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10542170" ], "products": [ "species_10542697" ], "modifiers": [], "additional_components": [ "Q21733", "WBGene00000904", "P45897", "WBGene00004858", "Q19404", "WBGene00008748", "Q19404", "WBGene00008748", "P45897", "WBGene00004858", "Q21733", "WBGene00000904" ] }, "reaction_10543404": { "compartment": "compartment_7660", "id": "reaction_10543404", "reactome": "R-CEL-2176475", "name": "Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10511518" ], "products": [ "species_113582", "species_10543397" ], "modifiers": [ [ "species_10543401", "catalyst" ] ], "additional_components": [ "P45897", "WBGene00004858", "Q21733", "WBGene00000904", "Q21733", "WBGene00000904", "P45897", "WBGene00004858", "Q9TVL3", "WBGene00000410", "P34424", "WBGene00000508", "P34425", "WBGene00000507", "O17869", "WBGene00009650", "P90866", "WBGene00000409", "Q9TYP2", "WBGene00000506" ] }, "reaction_10542172": { "compartment": "compartment_70101", "id": "reaction_10542172", "reactome": "R-CEL-2031355", "name": "WWTR1 binds SMAD2/3:SMAD4 heterotrimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10541983", "species_10511417" ], "products": [ "species_10542170" ], "modifiers": [], "additional_components": [ "WBGene00008748", "Q21733", "WBGene00000904", "P45897", "WBGene00004858", "Q21733", "WBGene00000904", "P45897", "WBGene00004858", "Q19404", "WBGene00008748" ] }, "reaction_10551215": { "compartment": "compartment_13231", "id": "reaction_10551215", "reactome": "R-CEL-5252001", "name": "ATP1B4 binds SNW1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10551211", "species_10505091" ], "products": [ "species_10551213" ], "modifiers": [], "additional_components": [ "Q93235", "WBGene00007646", "Q9XUG9", "WBGene00008074", "Q9XUY5", "WBGene00010117", "WBGene00004806", "Q22836", "WBGene00004806", "Q93235", "WBGene00007646", "Q9XUG9", "WBGene00008074", "Q9XUY5", "WBGene00010117" ] }, "reaction_10543472": { "compartment": "compartment_70101", "id": "reaction_10543472", "reactome": "R-CEL-2187395", "name": "Dephosphorylated SMAD2/3 translocates to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10516318" ], "products": [ "species_10511457" ], "modifiers": [], "additional_components": [ "WBGene00000904", "WBGene00000904" ] }, "reaction_10543410": { "compartment": "compartment_7660", "id": "reaction_10543410", "reactome": "R-CEL-2176491", "name": "NEDD4L binds phosphorylated linker region of SMAD2/3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10543406", "species_10543397" ], "products": [ "species_10543408" ], "modifiers": [], "additional_components": [ "WBGene00022358", "Q21733", "WBGene00000904", "P45897", "WBGene00004858", "Q21733", "WBGene00000904", "P45897", "WBGene00004858", "A0A061ACQ8", "WBGene00022358" ] }, "reaction_10516323": { "compartment": "compartment_7660", "id": "reaction_10516323", "reactome": "R-CEL-209055", "name": "PPM1A dephosphorylates nuclear SMAD2/3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10516316" ], "products": [ "species_113550", "species_10516318", "species_10516314", "species_10511512" ], "modifiers": [ [ "species_10516316", "catalyst" ] ], "additional_components": [ "Q19775", "WBGene00006460", "P45897", "WBGene00004858", "Q21733", "WBGene00000904", "WBGene00000904", "WBGene00006460", "WBGene00004858", "Q19775", "WBGene00006460", "P45897", "WBGene00004858", "Q21733", "WBGene00000904" ] }, "reaction_10543414": { "compartment": "compartment_7660", "id": "reaction_10543414", "reactome": "R-CEL-2176502", "name": "NEDD4L ubiquitinates SMAD2/3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502318", "species_10543408" ], "products": [ "species_10543406", "species_10543412" ], "modifiers": [], "additional_components": [ "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "Q21733", "WBGene00000904", "P45897", "WBGene00004858", "A0A061ACQ8", "WBGene00022358", "WBGene00022358", "Q21733", "WBGene00000904", "P45897", "WBGene00004858", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725" ] }, "reaction_10543416": { "compartment": "compartment_7660", "id": "reaction_10543416", "reactome": "R-CEL-2176503", "name": "Degradation of SMAD2/3:SMAD4 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10543412" ], "products": [], "modifiers": [], "additional_components": [ "Q21733", "WBGene00000904", "P45897", "WBGene00004858", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725" ] }, "reaction_10528057": { "compartment": "compartment_7660", "id": "reaction_10528057", "reactome": "R-CEL-870477", "name": "Ubiquitinated SMAD4 translocates from the nucleus to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10528053" ], "products": [ "species_10528055" ], "modifiers": [], "additional_components": [ "P45897", "WBGene00004858", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "P45897", "WBGene00004858" ] }, "reaction_10511547": { "compartment": "compartment_7660", "id": "reaction_10511547", "reactome": "R-CEL-173545", "name": "Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10511518" ], "products": [], "modifiers": [ [ "species_10511544", "catalyst" ] ], "additional_components": [ "P45897", "WBGene00004858", "Q21733", "WBGene00000904", "P35129", "WBGene00002344", "P91853", "WBGene00006732", "Q17720", "WBGene00006717", "Q20617", "WBGene00006719" ] }, "reaction_10543470": { "compartment": "compartment_7660", "id": "reaction_10543470", "reactome": "R-CEL-2187388", "name": "PPM1A protein phosphatase binds phosphorylated SMAD2/3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10511518", "species_10516314" ], "products": [ "species_10516316" ], "modifiers": [], "additional_components": [ "P45897", "WBGene00004858", "Q21733", "WBGene00000904", "WBGene00006460", "Q19775", "WBGene00006460", "P45897", "WBGene00004858", "Q21733", "WBGene00000904" ] }, "reaction_10548818": { "compartment": "compartment_876", "id": "reaction_10548818", "reactome": "R-CEL-3928654", "name": "Clathrin internalises EPH:EFN complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10548814", "species_10512890", "species_10512936", "species_10548503", "species_10548802" ], "products": [ "species_10548816" ], "modifiers": [], "additional_components": [ "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "WBGene00001130", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "O61460", "WBGene00006868", "P0DM42", "WBGene00000065", "P10984", "WBGene00000064", "P10986", "WBGene00000066", "P0DM41", "WBGene00000063", "species_29358", "P0DM42", "WBGene00000065", "P10984", "WBGene00000064", "P10986", "WBGene00000066", "P0DM41", "WBGene00000063", "species_29358", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "O61460", "WBGene00006868", "P39055", "WBGene00001130", "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "P35603", "WBGene00001082", "Q19123", "WBGene00000157" ] }, "reaction_10549028": { "compartment": "compartment_70101", "id": "reaction_10549028", "reactome": "R-CEL-4093327", "name": "EPHA binds TIAM1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10548777", "species_10516084" ], "products": [ "species_10548779" ], "modifiers": [], "additional_components": [ "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "O61460", "WBGene00006868", "Q9N3S5", "WBGene00021635", "G5EE56", "WBGene00005077", "WBGene00015704", "O01847", "WBGene00015704", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "O61460", "WBGene00006868", "Q9N3S5", "WBGene00021635", "G5EE56", "WBGene00005077" ] }, "reaction_10548616": { "compartment": "compartment_876", "id": "reaction_10548616", "reactome": "R-CEL-3928604", "name": "SFKs phosphorylate VAV2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10548611" ], "products": [ "species_29370", "species_10548613" ], "modifiers": [ [ "species_10548611", "catalyst" ] ], "additional_components": [ "O61460", "WBGene00006868", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "Q9N3S5", "WBGene00021635", "G5EE56", "WBGene00005077", "Q45FX5", "WBGene00006887", "O61460", "WBGene00006868", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "Q9N3S5", "WBGene00021635", "G5EE56", "WBGene00005077", "Q45FX5", "WBGene00006887", "O61460", "WBGene00006868", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "Q9N3S5", "WBGene00021635", "G5EE56", "WBGene00005077", "Q45FX5", "WBGene00006887" ] }, "reaction_10548857": { "compartment": "compartment_876", "id": "reaction_10548857", "reactome": "R-CEL-3928657", "name": "MMP2,9 cleave EPHB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10548503" ], "products": [ "species_10548844", "species_10548491", "species_10548820" ], "modifiers": [ [ "species_10548854", "catalyst" ] ], "additional_components": [ "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "O61460", "WBGene00006868", "WBGene00006868", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "WBGene00006868", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "Q21182", "WBGene00194737" ] }, "reaction_10548842": { "compartment": "compartment_876", "id": "reaction_10548842", "reactome": "R-CEL-3928656", "name": "gamma-secretase cleaves EPHB2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10548820" ], "products": [ "species_10548830", "species_10548840" ], "modifiers": [ [ "species_10532586", "catalyst" ] ], "additional_components": [ "WBGene00006868", "WBGene00006868", "WBGene00006868", "Q23316", "WBGene00000148", "P52166", "WBGene00004769", "Q01608", "WBGene00004958", "O02100", "WBGene00001985", "Q9U357", "WBGene00003975", "O45876", "WBGene00000147" ] }, "reaction_10548618": { "compartment": "compartment_876", "id": "reaction_10548618", "reactome": "R-CEL-3928607", "name": "p-EPHs bind VAV2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10516077", "species_10548609" ], "products": [ "species_10548611" ], "modifiers": [], "additional_components": [ "WBGene00006887", "O61460", "WBGene00006868", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "Q9N3S5", "WBGene00021635", "G5EE56", "WBGene00005077", "O61460", "WBGene00006868", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "Q9N3S5", "WBGene00021635", "G5EE56", "WBGene00005077", "Q45FX5", "WBGene00006887" ] }, "reaction_10548763": { "compartment": "compartment_876", "id": "reaction_10548763", "reactome": "R-CEL-3928628", "name": "VAV exchanges GTP for GDP on RAC1, activating it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10520575", "species_29438" ], "products": [ "species_29420", "species_10509457" ], "modifiers": [ [ "species_10548613", "catalyst" ] ], "additional_components": [ "species_29420", "Q03206", "ced-10", "species_29438", "Q03206", "ced-10", "O61460", "WBGene00006868", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "Q9N3S5", "WBGene00021635", "G5EE56", "WBGene00005077", "Q45FX5", "WBGene00006887" ] }, "reaction_10548782": { "compartment": "compartment_876", "id": "reaction_10548782", "reactome": "R-CEL-3928642", "name": "TIAM1 exchanges GTP for GDP on RAC1, activating it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10520575", "species_29438" ], "products": [ "species_29420", "species_10509457" ], "modifiers": [ [ "species_10548779", "catalyst" ] ], "additional_components": [ "species_29420", "Q03206", "ced-10", "species_29438", "Q03206", "ced-10", "O01847", "WBGene00015704", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "O61460", "WBGene00006868", "Q9N3S5", "WBGene00021635", "G5EE56", "WBGene00005077" ] }, "reaction_10572371": { "compartment": "compartment_161320", "id": "reaction_10572371", "reactome": "R-CEL-9638078", "name": "HEXB cleaves the terminal GalNAc from keratan sulfate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2105012" ], "products": [ "species_2105010", "species_1605658" ], "modifiers": [ [ "species_10536355", "catalyst" ] ], "additional_components": [ "Q22492", "WBGene00020509" ] }, "reaction_10536644": { "compartment": "compartment_161320", "id": "reaction_10536644", "reactome": "R-CEL-1638053", "name": "HEXA cleaves the terminal GalNAc from keratan sulfate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2105012" ], "products": [ "species_2105010", "species_1605658" ], "modifiers": [ [ "species_10536342", "catalyst" ] ], "additional_components": [ "Q22492", "WBGene00020509" ] }, "reaction_10536555": { "compartment": "compartment_161320", "id": "reaction_10536555", "reactome": "R-CEL-1630306", "name": "GLB1 hydrolyses a glycosaminoglycan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2104997" ], "products": [ "species_1605637", "species_2104995" ], "modifiers": [ [ "species_10536350", "catalyst" ] ], "additional_components": [ "WBGene00011832" ] }, "reaction_10542450": { "compartment": "compartment_17963", "id": "reaction_10542450", "reactome": "R-CEL-2076383", "name": "HS3ST1 sulfates GlcN at C3 in heparan sulfate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_741440", "species_10541552" ], "products": [ "species_742343", "species_10541588" ], "modifiers": [ [ "species_10542445", "catalyst" ] ], "additional_components": [ "G5EGU4", "WBGene00001687", "Q18530", "WBGene00003056", "P50605", "WBGene00004749", "P34710", "unc-6", "P34710", "unc-6", "Q18530", "WBGene00003056", "G5EGU4", "WBGene00001687", "P50605", "WBGene00004749", "WBGene00002030" ] }, "reaction_10542484": { "compartment": "compartment_20699", "id": "reaction_10542484", "reactome": "R-CEL-2076611", "name": "HS3STs sulfate GlcN at C3 in heparan sulfate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_741440", "species_10541552" ], "products": [ "species_742343", "species_10541588" ], "modifiers": [ [ "species_10542481", "catalyst" ] ], "additional_components": [ "G5EGU4", "WBGene00001687", "Q18530", "WBGene00003056", "P50605", "WBGene00004749", "P34710", "unc-6", "P34710", "unc-6", "Q18530", "WBGene00003056", "G5EGU4", "WBGene00001687", "P50605", "WBGene00004749", "Q4TTA0", "WBGene00044303", "Q9TZK5", "WBGene00002030" ] }, "reaction_10541429": { "compartment": "compartment_20699", "id": "reaction_10541429", "reactome": "R-CEL-2022860", "name": "NDST1-4 can sulfate a glucosamine residue in heparan to form heparan sulfate (HS)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_741440", "species_10541379" ], "products": [ "species_742343", "species_10541415" ], "modifiers": [ [ "species_10541420", "catalyst" ] ], "additional_components": [ "P34710", "unc-6", "Q18530", "WBGene00003056", "G5EGU4", "WBGene00001687", "P50605", "WBGene00004749", "G5EGU4", "WBGene00001687", "P34710", "unc-6", "Q18530", "WBGene00003056", "P50605", "WBGene00004749", "WBGene00002028" ] }, "reaction_10542470": { "compartment": "compartment_20699", "id": "reaction_10542470", "reactome": "R-CEL-2076508", "name": "HS2ST1 sulfates IdoA at C2 in heparan sulfate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10541516", "species_741440" ], "products": [ "species_742343", "species_10541552" ], "modifiers": [ [ "species_10542467", "catalyst" ] ], "additional_components": [ "G5EGU4", "WBGene00001687", "Q18530", "WBGene00003056", "P50605", "WBGene00004749", "P34710", "unc-6", "G5EGU4", "WBGene00001687", "Q18530", "WBGene00003056", "P50605", "WBGene00004749", "P34710", "unc-6", "WBGene00002029" ] }, "reaction_10541468": { "compartment": "compartment_20699", "id": "reaction_10541468", "reactome": "R-CEL-2022887", "name": "NDST1-4 N-deacetylates GlcNAc residues in heparan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2022884", "species_10541465" ], "products": [ "species_2022890", "species_10541379" ], "modifiers": [ [ "species_10541420", "catalyst" ] ], "additional_components": [ "G5EGU4", "WBGene00001687", "Q18530", "WBGene00003056", "P50605", "WBGene00004749", "P34710", "unc-6", "P34710", "unc-6", "Q18530", "WBGene00003056", "G5EGU4", "WBGene00001687", "P50605", "WBGene00004749", "WBGene00002028" ] }, "reaction_10542462": { "compartment": "compartment_20699", "id": "reaction_10542462", "reactome": "R-CEL-2076419", "name": "HS6STs sulfate GlcN at C6 in heparan sulfate/heparin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_741440", "species_10541624" ], "products": [ "species_742343", "species_10541656" ], "modifiers": [ [ "species_10542455", "catalyst" ] ], "additional_components": [ "P50605", "WBGene00004749", "G5EGU4", "WBGene00001687", "P34710", "unc-6", "Q18530", "WBGene00003056", "G5EGU4", "WBGene00001687", "Q18530", "WBGene00003056", "P50605", "WBGene00004749", "P34710", "unc-6", "WBGene00002031" ] }, "reaction_10541822": { "compartment": "compartment_17963", "id": "reaction_10541822", "reactome": "R-CEL-2024108", "name": "Some HSPGs are secreted to the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10541658" ], "products": [ "species_10541820" ], "modifiers": [], "additional_components": [ "G5EGU4", "WBGene00001687", "Q18530", "WBGene00003056", "P50605", "WBGene00004749", "P34710", "unc-6", "G5EGU4", "WBGene00001687", "Q18530", "WBGene00003056", "P34710", "unc-6", "P50605", "WBGene00004749" ] }, "reaction_10538116": { "compartment": "compartment_20699", "id": "reaction_10538116", "reactome": "R-CEL-1889978", "name": "B3GALT6 transfers Gal to the tetrasaccharide linker", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10538108", "species_735682" ], "products": [ "species_10537964", "species_205687" ], "modifiers": [ [ "species_10538113", "catalyst" ] ], "additional_components": [ "G5EGU4", "WBGene00001687", "Q18530", "WBGene00003056", "P50605", "WBGene00004749", "P34710", "unc-6", "Q8IG72", "WBGene00016751", "G5EGU4", "WBGene00001687", "Q18530", "WBGene00003056", "P50605", "WBGene00004749", "P34710", "unc-6", "Q8IG72", "WBGene00016751", "WBGene00005020" ] }, "reaction_10537925": { "compartment": "compartment_20699", "id": "reaction_10537925", "reactome": "R-CEL-1878002", "name": "XYLTs transfer Xyl to core protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10537876", "species_742361" ], "products": [ "species_10537915", "species_205687" ], "modifiers": [ [ "species_10537920", "catalyst" ] ], "additional_components": [ "Q18530", "WBGene00003056", "G5EGU4", "WBGene00001687", "Q8IG72", "WBGene00016751", "P34710", "unc-6", "P50605", "WBGene00004749", "P50605", "WBGene00004749", "G5EGU4", "WBGene00001687", "P34710", "unc-6", "Q18530", "WBGene00003056", "Q8IG72", "WBGene00016751", "WBGene00005024" ] }, "reaction_10538069": { "compartment": "compartment_20699", "id": "reaction_10538069", "reactome": "R-CEL-1889955", "name": "B3GAT dimers transfer GlcA to tetrasaccharide linker", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1889970", "species_10537964" ], "products": [ "species_205687", "species_10538003" ], "modifiers": [ [ "species_10538066", "catalyst" ] ], "additional_components": [ "G5EGU4", "WBGene00001687", "Q18530", "WBGene00003056", "P50605", "WBGene00004749", "P34710", "unc-6", "Q8IG72", "WBGene00016751", "Q8IG72", "WBGene00016751", "G5EGU4", "WBGene00001687", "Q18530", "WBGene00003056", "P50605", "WBGene00004749", "P34710", "unc-6", "species_266099", "Q09363", "WBGene00005026", "O17708", "WBGene00008293", "Q9XU73", "WBGene00011781", "O17751", "WBGene00008479", "A0A0K3AUF6", "W07G9.2b", "O62113", "WBGene00008160", "O02304", "WBGene00011650" ] }, "reaction_10538124": { "compartment": "compartment_20699", "id": "reaction_10538124", "reactome": "R-CEL-1889981", "name": "B4GALT7 transfers Gal group to xylosyl-unit of the tetrasaccharide linker", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10537915", "species_735682" ], "products": [ "species_10538108", "species_205687" ], "modifiers": [ [ "species_10538121", "catalyst" ] ], "additional_components": [ "P50605", "WBGene00004749", "G5EGU4", "WBGene00001687", "P34710", "unc-6", "Q18530", "WBGene00003056", "Q8IG72", "WBGene00016751", "G5EGU4", "WBGene00001687", "Q18530", "WBGene00003056", "P50605", "WBGene00004749", "P34710", "unc-6", "Q8IG72", "WBGene00016751", "WBGene00005021" ] }, "reaction_10572364": { "compartment": "compartment_20699", "id": "reaction_10572364", "reactome": "R-CEL-9638064", "name": "B3GAT3 dimer transfers GlcA to tetrasaccharide linker", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1889970", "species_10537964" ], "products": [ "species_205687", "species_10538003" ], "modifiers": [ [ "species_10538064", "catalyst" ] ], "additional_components": [ "G5EGU4", "WBGene00001687", "Q18530", "WBGene00003056", "P50605", "WBGene00004749", "P34710", "unc-6", "Q8IG72", "WBGene00016751", "Q8IG72", "WBGene00016751", "G5EGU4", "WBGene00001687", "Q18530", "WBGene00003056", "P50605", "WBGene00004749", "P34710", "unc-6", "species_266099", "Q09363", "WBGene00005026" ] }, "reaction_10537394": { "compartment": "compartment_161320", "id": "reaction_10537394", "reactome": "R-CEL-1678742", "name": "NAGLU hydrolyses Heparan sulfate chain(4)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2090069" ], "products": [ "species_2090080", "species_1678743" ], "modifiers": [ [ "species_10537391", "catalyst" ] ], "additional_components": [ "WBGene00010722" ] }, "reaction_10542691": { "compartment": "compartment_161320", "id": "reaction_10542691", "reactome": "R-CEL-2090038", "name": "NAGLU hydrolyses heparan chain(2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2090053" ], "products": [ "species_1678743", "species_2065212" ], "modifiers": [ [ "species_10537391", "catalyst" ] ], "additional_components": [ "WBGene00010722" ] }, "reaction_10542693": { "compartment": "compartment_161320", "id": "reaction_10542693", "reactome": "R-CEL-2090079", "name": "GLB1 hydrolyses linker chain(2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2090075" ], "products": [ "species_1605637", "species_2090063" ], "modifiers": [ [ "species_10536350", "catalyst" ] ], "additional_components": [ "WBGene00011832" ] }, "reaction_10541480": { "compartment": "compartment_876", "id": "reaction_10541480", "reactome": "R-CEL-2024084", "name": "HS-GAGs translocate to the lysosome for degradation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10537360" ], "products": [ "species_10537017" ], "modifiers": [], "additional_components": [ "G5EGU4", "WBGene00001687", "Q18530", "WBGene00003056", "P34710", "unc-6", "P50605", "WBGene00004749", "P50605", "WBGene00004749", "P34710", "unc-6", "G5EGU4", "WBGene00001687", "Q18530", "WBGene00003056" ] }, "reaction_10537435": { "compartment": "compartment_161320", "id": "reaction_10537435", "reactome": "R-CEL-1678854", "name": "GUSB tetramer hydrolyses CS/HS precursor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2065212" ], "products": [ "species_1678868", "species_2090075" ], "modifiers": [ [ "species_10537432", "catalyst" ], [ "species_427963", "inhibitor" ] ], "additional_components": [ "Q95Q32", "WBGene00013693" ] }, "reaction_10542856": { "compartment": "compartment_876", "id": "reaction_10542856", "reactome": "R-CEL-2142859", "name": "Growing HA is extruded from the cell by ABCC5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2142896" ], "products": [ "species_2160848" ], "modifiers": [ [ "species_10534273", "catalyst" ] ], "additional_components": [ "species_2162224", "species_2162224", "WBGene00003411" ] }, "reaction_10540904": { "compartment": "compartment_17963", "id": "reaction_10540904", "reactome": "R-CEL-2022065", "name": "DSPGs are secreted", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10540902" ], "products": [ "species_10540868" ], "modifiers": [], "additional_components": [ "Q8IG72", "WBGene00016751", "Q8IG72", "WBGene00016751" ] }, "reaction_10537457": { "compartment": "compartment_161320", "id": "reaction_10537457", "reactome": "R-CEL-1793209", "name": "HYAL1 hydrolyses Chondroitin chains", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2065257" ], "products": [ "species_2065212" ], "modifiers": [ [ "species_10537452", "catalyst" ] ], "additional_components": [ "CHEBI:63512", "CHEBI:63513", "CHEBI:63515", "species_2065239", "WBGene00011923" ] }, "reaction_10536470": { "compartment": "compartment_161320", "id": "reaction_10536470", "reactome": "R-CEL-1606789", "name": "ARSB hydrolyses DS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2065231" ], "products": [ "species_1606845", "species_2065213" ], "modifiers": [ [ "species_10536467", "catalyst" ] ], "additional_components": [ "A0A4V0IJ66", "WBGene00006310", "species_74016" ] }, "reaction_10542695": { "compartment": "compartment_161320", "id": "reaction_10542695", "reactome": "R-CEL-2105001", "name": "HEXA cleaves the terminal GalNAc from DS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2065269" ], "products": [ "species_1605658", "species_2105025" ], "modifiers": [ [ "species_10536342", "catalyst" ] ], "additional_components": [ "Q22492", "WBGene00020509" ] }, "reaction_10537447": { "compartment": "compartment_161320", "id": "reaction_10537447", "reactome": "R-CEL-1793207", "name": "ARSB hydrolyses C4S/C6S chains", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2065251", "species_1605715" ], "products": [ "species_2065239", "species_1606845" ], "modifiers": [ [ "species_10536467", "catalyst" ] ], "additional_components": [ "CHEBI:63512", "CHEBI:63513", "A0A4V0IJ66", "WBGene00006310", "species_74016" ] }, "reaction_10540892": { "compartment": "compartment_984", "id": "reaction_10540892", "reactome": "R-CEL-2022056", "name": "DSPG and CSPG translocate to the lysosome for degradation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10540876", "species_10540868" ], "products": [ "species_10540890", "species_10540884" ], "modifiers": [], "additional_components": [ "Q8IG72", "WBGene00016751", "Q8IG72", "WBGene00016751", "Q8IG72", "WBGene00016751", "Q8IG72", "WBGene00016751" ] }, "reaction_10572367": { "compartment": "compartment_161320", "id": "reaction_10572367", "reactome": "R-CEL-9638075", "name": "HEXB cleaves the terminal GalNAc from DS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2065269" ], "products": [ "species_1605658", "species_2105025" ], "modifiers": [ [ "species_10536355", "catalyst" ] ], "additional_components": [ "Q22492", "WBGene00020509" ] }, "reaction_10541472": { "compartment": "compartment_17963", "id": "reaction_10541472", "reactome": "R-CEL-2022911", "name": "CSPG is secreted", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10541470" ], "products": [ "species_10540876" ], "modifiers": [], "additional_components": [ "Q8IG72", "WBGene00016751", "Q8IG72", "WBGene00016751" ] }, "reaction_10572304": { "compartment": "compartment_20699", "id": "reaction_10572304", "reactome": "R-CEL-9632034", "name": "CHSY1 transfers GlcA to chondroitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1889970", "species_10538300" ], "products": [ "species_10538309", "species_205687" ], "modifiers": [ [ "species_10572298", "catalyst" ] ], "additional_components": [ "WBGene00016751", "WBGene00016751", "WBGene00005023" ] }, "reaction_10538324": { "compartment": "compartment_20699", "id": "reaction_10538324", "reactome": "R-CEL-1971487", "name": "CHPF,CHSY3 transfer GalNAc to chondroitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_735700", "species_10538309" ], "products": [ "species_10538303", "species_205687" ], "modifiers": [ [ "species_10538321", "catalyst" ] ], "additional_components": [ "WBGene00016751", "WBGene00016751", "P45895", "WBGene00003253", "Q7Z1Z1", "WBGene00005023" ] }, "reaction_10538329": { "compartment": "compartment_20699", "id": "reaction_10538329", "reactome": "R-CEL-1971491", "name": "CHPF,CHPF2,CHSY3 transfer GlcA to chondroitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1889970", "species_10538300" ], "products": [ "species_10538309", "species_205687" ], "modifiers": [ [ "species_10538321", "catalyst" ] ], "additional_components": [ "WBGene00016751", "WBGene00016751", "P45895", "WBGene00003253", "Q7Z1Z1", "WBGene00005023" ] }, "reaction_10572301": { "compartment": "compartment_20699", "id": "reaction_10572301", "reactome": "R-CEL-9632033", "name": "CHSY1 transfers GalNAc to chondroitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_735700", "species_10538309" ], "products": [ "species_10538303", "species_205687" ], "modifiers": [ [ "species_10572298", "catalyst" ] ], "additional_components": [ "WBGene00016751", "WBGene00016751", "WBGene00005023" ] }, "reaction_10510178": { "compartment": "compartment_5460", "id": "reaction_10510178", "reactome": "R-CEL-163310", "name": "TFAM binds to mitochondrial promoters", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10510174", "species_163305" ], "products": [ "species_10510176" ], "modifiers": [], "additional_components": [ "WBGene00001975", "Q94234", "WBGene00001975" ] }, "reaction_10508532": { "compartment": "compartment_876", "id": "reaction_10508532", "reactome": "R-CEL-109701", "name": "PDPK1 binds PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179838", "species_10508528" ], "products": [ "species_10508530" ], "modifiers": [], "additional_components": [ "WBGene00021022", "Q9UA62", "WBGene00021022", "species_179838" ] }, "reaction_10508551": { "compartment": "compartment_70101", "id": "reaction_10508551", "reactome": "R-CEL-109702", "name": "PDPK1 phosphorylates AKT2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10508521" ], "products": [ "species_29370", "species_10508548" ], "modifiers": [ [ "species_10508530", "catalyst" ] ], "additional_components": [ "Q9XTG7", "WBGene00000103", "G4S4W1", "WBGene00016980", "Q17941", "WBGene00000102", "species_179838", "Q9XTG7", "WBGene00000103", "G4S4W1", "WBGene00016980", "Q17941", "WBGene00000102", "species_179838", "Q9UA62", "WBGene00021022", "species_179838" ] }, "reaction_10508523": { "compartment": "compartment_876", "id": "reaction_10508523", "reactome": "R-CEL-109700", "name": "AKT2 binds PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179838", "species_10508519" ], "products": [ "species_10508521", "species_10508500" ], "modifiers": [], "additional_components": [ "G5EED4", "WBGene00010700", "Q9XTG7", "WBGene00000103", "G4S4W1", "WBGene00016980", "Q17941", "WBGene00000102", "Q9XTG7", "WBGene00000103", "G4S4W1", "WBGene00016980", "Q17941", "WBGene00000102", "species_179838", "WBGene00010700" ] }, "reaction_10510068": { "compartment": "compartment_70101", "id": "reaction_10510068", "reactome": "R-CEL-162425", "name": "p-S295-PDE3B hydrolyses cAMP to AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_30389" ], "products": [ "species_76577" ], "modifiers": [ [ "species_10510065", "catalyst" ] ], "additional_components": [ "WBGene00008443" ] }, "reaction_10508495": { "compartment": "compartment_70101", "id": "reaction_10508495", "reactome": "R-CEL-109699", "name": "PI3K-containing complexes phosphorylate PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10508492", "catalyst" ] ], "additional_components": [ "G5EDP9", "WBGene00000001", "A0A1I6CMA1", "WBGene00020678", "G5EGT9", "WBGene00003007", "P29355", "WBGene00004774", "G5EDJ4", "WBGene00004928" ] }, "reaction_10513499": { "compartment": "compartment_876", "id": "reaction_10513499", "reactome": "R-CEL-194518", "name": "RhoA is activated by nucleotide exchange and inhibits axonal growth", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509486" ], "products": [ "species_10509488" ], "modifiers": [ [ "species_10513496", "catalyst" ] ], "additional_components": [ "Q22038", "WBGene00004357", "species_29420", "Q22038", "WBGene00004357", "species_29438", "WBGene00006496" ] }, "reaction_10522807": { "compartment": "compartment_7660", "id": "reaction_10522807", "reactome": "R-CEL-427514", "name": "eNoSC deacetylates histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10522790", "species_427523" ], "products": [ "species_427497", "species_427498", "species_10517072" ], "modifiers": [ [ "species_10522804", "catalyst" ] ], "additional_components": [ "P62784", "WBGene00001875", "Q10453", "WBGene00001945", "K7ZUH9", "WBGene00001914", "P62784", "WBGene00001875", "K7ZUH9", "WBGene00001914", "Q10453", "WBGene00001945", "Q21921", "WBGene00004800", "O44410", "WBGene00020296", "P62784", "WBGene00001875", "K7ZUH9", "WBGene00001914", "Q10453", "WBGene00001945" ] }, "reaction_10522810": { "compartment": "compartment_7660", "id": "reaction_10522810", "reactome": "R-CEL-427527", "name": "eNoSC dimethylates histone H3 at lysine-9", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10517072" ], "products": [ "species_77502", "species_10507005" ], "modifiers": [ [ "species_10522804", "catalyst" ] ], "additional_components": [ "P62784", "WBGene00001875", "K7ZUH9", "WBGene00001914", "Q10453", "WBGene00001945", "P62784", "WBGene00001875", "K7ZUH9", "WBGene00001914", "Q10453", "WBGene00001945", "Q21921", "WBGene00004800", "O44410", "WBGene00020296", "P62784", "WBGene00001875", "K7ZUH9", "WBGene00001914", "Q10453", "WBGene00001945" ] }, "reaction_10522776": { "compartment": "compartment_7660", "id": "reaction_10522776", "reactome": "R-CEL-427337", "name": "MBD2 binds methylcytosine in chromatin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10522772", "species_10522770" ], "products": [ "species_10522774" ], "modifiers": [], "additional_components": [ "P62784", "WBGene00001875", "K7ZUH9", "WBGene00001914", "Q10453", "WBGene00001945", "WBGene00023409", "G5ECR1", "WBGene00023409", "P62784", "WBGene00001875", "K7ZUH9", "WBGene00001914", "Q10453", "WBGene00001945" ] }, "reaction_10547602": { "compartment": "compartment_70101", "id": "reaction_10547602", "reactome": "R-CEL-3371435", "name": "Constitutive phosphorylation by GSK3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10547597", "species_113592" ], "products": [ "species_29370", "species_10547600" ], "modifiers": [ [ "species_10513574", "catalyst" ] ], "additional_components": [ "WBGene00002004", "WBGene00002004", "Q9U2Q9", "WBGene00001746", "Q09595", "WBGene00010991", "Q93372", "WBGene00010991" ] }, "reaction_10547682": { "compartment": "compartment_7660", "id": "reaction_10547682", "reactome": "R-CEL-3371537", "name": "DBC1 binds SIRT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10547678", "species_10522802" ], "products": [ "species_10547680" ], "modifiers": [], "additional_components": [ "Y37A1B.1a", "WBGene00004800", "Q21921", "WBGene00004800", "A0A0S4XR43", "Y37A1B.1a" ] }, "reaction_10551170": { "compartment": "compartment_7660", "id": "reaction_10551170", "reactome": "R-CEL-5251955", "name": "HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10551131" ], "products": [ "species_113550", "species_10551129", "species_10551155" ], "modifiers": [ [ "species_10551167", "catalyst" ] ], "additional_components": [ "species_29358", "G5EC99", "WBGene00009691", "G5ECU5", "WBGene00009691", "O45246", "WBGene00002026", "K8ERU5", "WBGene00018328", "WBGene00018328", "G5EC99", "WBGene00009691", "G5ECU5", "WBGene00009691", "O45246", "WBGene00002026", "species_113582", "Q9TY07", "WBGene00001042", "Q94216", "WBGene00001029" ] }, "reaction_10551203": { "compartment": "compartment_70101", "id": "reaction_10551203", "reactome": "R-CEL-5251959", "name": "HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10551073" ], "products": [ "species_29372", "species_10551194" ], "modifiers": [ [ "species_10551200", "catalyst" ] ], "additional_components": [ "G5ECU5", "WBGene00009691", "O45246", "WBGene00002026", "G5EC99", "WBGene00009691", "species_29358", "G5ECU5", "WBGene00009691", "O45246", "WBGene00002026", "G5EC99", "WBGene00009691", "species_113582", "Q9TY07", "WBGene00001042", "Q94216", "WBGene00001029" ] }, "reaction_10551077": { "compartment": "compartment_70101", "id": "reaction_10551077", "reactome": "R-CEL-5251942", "name": "Hikeshi binds HSP70s:ATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10551014", "species_10551073" ], "products": [ "species_10551075" ], "modifiers": [], "additional_components": [ "WBGene00018328", "G5ECU5", "WBGene00009691", "O45246", "WBGene00002026", "G5EC99", "WBGene00009691", "species_29358", "G5ECU5", "WBGene00009691", "O45246", "WBGene00002026", "G5EC99", "WBGene00009691", "species_29358", "K8ERU5", "WBGene00018328" ] }, "reaction_10549720": { "compartment": "compartment_70101", "id": "reaction_10549720", "reactome": "R-CEL-4793911", "name": "MAPKAPK2 phosphorylates HSF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10547597", "species_113592" ], "products": [ "species_29370", "species_10549717" ], "modifiers": [ [ "species_10512624", "catalyst" ] ], "additional_components": [ "WBGene00002004", "WBGene00002004", "Q21360", "WBGene00010681", "Q965G5", "WBGene00007007" ] }, "reaction_10551241": { "compartment": "compartment_70101", "id": "reaction_10551241", "reactome": "R-CEL-5252079", "name": "HSP110s exchange ATP for ADP on HSP70s:ADP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10551194", "species_113592" ], "products": [ "species_29370", "species_10551073" ], "modifiers": [ [ "species_10551231", "catalyst" ], [ "species_10551239", "inhibitor" ] ], "additional_components": [ "G5ECU5", "WBGene00009691", "O45246", "WBGene00002026", "G5EC99", "WBGene00009691", "species_113582", "G5ECU5", "WBGene00009691", "O45246", "WBGene00002026", "G5EC99", "WBGene00009691", "species_29358", "Q05036", "WBGene00016250", "O44739", "WBGene00000236", "O61980", "WBGene00006760", "G5EE04", "WBGene00011735" ] }, "reaction_10547675": { "compartment": "compartment_70101", "id": "reaction_10547675", "reactome": "R-CEL-3371531", "name": "Constitutive phosphorylation by pERK1/2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10547597", "species_113592" ], "products": [ "species_29370", "species_10547673" ], "modifiers": [ [ "species_10542082", "catalyst" ] ], "additional_components": [ "WBGene00002004", "WBGene00002004", "P39745", "WBGene00003401" ] }, "reaction_10547692": { "compartment": "compartment_7660", "id": "reaction_10547692", "reactome": "R-CEL-3371567", "name": "DBC1 is phosphorylated by ATM/ART", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10547684" ], "products": [ "species_113582", "species_10547678" ], "modifiers": [ [ "species_10547689", "catalyst" ] ], "additional_components": [ "Y37A1B.1a", "Y37A1B.1a", "WBGene00000226" ] }, "reaction_10549888": { "compartment": "compartment_7660", "id": "reaction_10549888", "reactome": "R-CEL-5082409", "name": "Dissociation of HSF1:HSP90 complex in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10549886" ], "products": [ "species_10549884", "species_10549878", "species_10549859" ], "modifiers": [], "additional_components": [ "G5EFT5", "WBGene00002004", "Q23280", "WBGene00022599", "Q18688", "WBGene00000915", "Q18688", "WBGene00000915", "WBGene00022599", "WBGene00002004" ] }, "reaction_10547717": { "compartment": "compartment_70101", "id": "reaction_10547717", "reactome": "R-CEL-3371591", "name": "Trimerization of cytosolic HSF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10547597" ], "products": [ "species_10547664" ], "modifiers": [ [ "species_10509904", "catalyst" ] ], "additional_components": [ "WBGene00002004", "G5EFT5", "WBGene00002004", "WBGene00001168" ] }, "reaction_10549861": { "compartment": "compartment_7660", "id": "reaction_10549861", "reactome": "R-CEL-5082391", "name": "Trimerization of HSF1 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10549859" ], "products": [ "species_10547668" ], "modifiers": [], "additional_components": [ "WBGene00002004", "G5EFT5", "WBGene00002004" ] }, "reaction_10547670": { "compartment": "compartment_70101", "id": "reaction_10547670", "reactome": "R-CEL-3371527", "name": "HSF1 trimer translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10547664" ], "products": [ "species_10547668" ], "modifiers": [], "additional_components": [ "G5EFT5", "WBGene00002004", "G5EFT5", "WBGene00002004" ] }, "reaction_10551291": { "compartment": "compartment_70101", "id": "reaction_10551291", "reactome": "R-CEL-5324632", "name": "Dissociation of cytosolic HSF1:HSP90:HDAC6:PTGES3 upon sensing protein aggregates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5324631", "species_10551286" ], "products": [ "species_10547597", "species_10517708", "species_10551288", "species_10547652" ], "modifiers": [ [ "species_10551286", "catalyst" ] ], "additional_components": [ "Q18688", "WBGene00000915", "P54812", "WBGene00008053", "Q23280", "WBGene00022599", "G5EFT5", "WBGene00002004", "Q20296", "WBGene00018319", "WBGene00002004", "WBGene00022599", "P54812", "WBGene00008053", "Q20296", "WBGene00018319", "Q18688", "WBGene00000915", "Q18688", "WBGene00000915", "P54812", "WBGene00008053", "Q23280", "WBGene00022599", "G5EFT5", "WBGene00002004", "Q20296", "WBGene00018319" ] }, "reaction_10547709": { "compartment": "compartment_70101", "id": "reaction_10547709", "reactome": "R-CEL-3371586", "name": "Dissociation of cytosolic HSF1:HSP90 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10547707" ], "products": [ "species_10547597", "species_10517708", "species_10547652" ], "modifiers": [], "additional_components": [ "Q18688", "WBGene00000915", "Q23280", "WBGene00022599", "G5EFT5", "WBGene00002004", "WBGene00002004", "WBGene00022599", "Q18688", "WBGene00000915" ] }, "reaction_10549857": { "compartment": "compartment_7660", "id": "reaction_10549857", "reactome": "R-CEL-5082387", "name": "Phosphorylation of HSF1 at Ser230 induces transactivation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10547668" ], "products": [ "species_113582", "species_10549835" ], "modifiers": [ [ "species_10549854", "catalyst" ] ], "additional_components": [ "G5EFT5", "WBGene00002004", "G5EFT5", "WBGene00002004", "O62305", "WBGene00006779" ] }, "reaction_10549842": { "compartment": "compartment_7660", "id": "reaction_10549842", "reactome": "R-CEL-5082356", "name": "HSF1-mediated gene expression", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10549772" ], "products": [ "species_10549830" ], "modifiers": [ [ "species_10549840", "catalyst" ], [ "species_10549835", "catalyst" ] ], "additional_components": [ "G5EFT5", "WBGene00002004", "Q9U3B7", "WBGene00002002", "Q20660", "WBGene00002021", "Q19227", "WBGene00014233", "P06581", "WBGene00002018", "B0M0L8", "WBGene00002024", "Q19228", "WBGene00014233", "P06582", "WBGene00002016", "G5EF99", "WBGene00014233", "Q20363", "WBGene00004798", "P34696", "WBGene00002015", "P02513", "WBGene00002019", "P09446", "WBGene00002005", "G5EC99", "WBGene00009691", "G5ECU5", "WBGene00009691", "O45246", "WBGene00002026", "Q18688", "WBGene00000915", "G5EFT5", "WBGene00002004", "G5EFT5", "WBGene00002004" ] }, "reaction_10549876": { "compartment": "compartment_7660", "id": "reaction_10549876", "reactome": "R-CEL-5082405", "name": "Phosphorylation of HSF1 at Ser326 induces transactivation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10547668" ], "products": [ "species_113582", "species_10549840" ], "modifiers": [ [ "species_10549873", "catalyst" ] ], "additional_components": [ "G5EFT5", "WBGene00002004", "G5EFT5", "WBGene00002004", "P91040", "WBGene00015697", "Q95Q95", "WBGene00002583", "Q68TI8", "WBGene00000911" ] }, "reaction_10547705": { "compartment": "compartment_7660", "id": "reaction_10547705", "reactome": "R-CEL-3371582", "name": "HSBP1 binds HSF1 trimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10547701", "species_10547668" ], "products": [ "species_10547703" ], "modifiers": [], "additional_components": [ "Q9U3B7", "WBGene00002002", "G5EFT5", "WBGene00002004", "G5EFT5", "WBGene00002004", "Q9U3B7", "WBGene00002002" ] }, "reaction_10551274": { "compartment": "compartment_7660", "id": "reaction_10551274", "reactome": "R-CEL-5324617", "name": "HSP90:FKBP4:PTGES3 binds HSF1 trimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10551270", "species_10547668" ], "products": [ "species_10551272" ], "modifiers": [], "additional_components": [ "O45418", "WBGene00001431", "Q23280", "WBGene00022599", "Q18688", "WBGene00000915", "G5EFT5", "WBGene00002004", "O45418", "WBGene00001431", "G5EFT5", "WBGene00002004", "Q23280", "WBGene00022599", "Q18688", "WBGene00000915" ] }, "reaction_10535090": { "compartment": "compartment_70616", "id": "reaction_10535090", "reactome": "R-CEL-1483165", "name": "PA is converted to CDP-DAG by CDS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524101", "species_110577" ], "products": [ "species_159450", "species_1524064" ], "modifiers": [ [ "species_10535087", "catalyst" ] ], "additional_components": [ "WBGene00016384" ] }, "reaction_10535537": { "compartment": "compartment_984", "id": "reaction_10535537", "reactome": "R-CEL-1566981", "name": "Fibronectin degradation by MMP1, 3, 7, 12, 13, 19, CTSS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10517394" ], "products": [ "species_10535515" ], "modifiers": [ [ "species_10535534", "catalyst" ] ], "additional_components": [ "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "Q21182", "WBGene00194737", "O45734", "WBGene00000776", "Q23030", "WBGene00019986", "Q93512", "WBGene00019986" ] }, "reaction_10536417": { "compartment": "compartment_17963", "id": "reaction_10536417", "reactome": "R-CEL-1605825", "name": "MT-MMPs are sorted to the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10536012" ], "products": [ "species_10536415" ], "modifiers": [], "additional_components": [ "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "Q21182", "WBGene00194737", "A0A0K3ARD1", "WBGene00194737", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "Q21182", "WBGene00194737" ] }, "reaction_10536167": { "compartment": "compartment_984", "id": "reaction_10536167", "reactome": "R-CEL-1604731", "name": "Autocatalytic activation of MMP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10535663" ], "products": [ "species_10536164", "species_10534164" ], "modifiers": [ [ "species_10535663", "catalyst" ] ], "additional_components": [ "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "Q21182", "WBGene00194737", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "Q21182", "WBGene00194737", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "Q21182", "WBGene00194737" ] }, "reaction_10536136": { "compartment": "compartment_984", "id": "reaction_10536136", "reactome": "R-CEL-1604690", "name": "Activation of MMP9 intermediate form by MMPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10535755" ], "products": [ "species_10536134", "species_10534192" ], "modifiers": [ [ "species_10535771", "catalyst" ] ], "additional_components": [ "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "Q21182", "WBGene00194737", "A0A0K3ARD1", "WBGene00194737", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "Q21182", "WBGene00194737", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "G5EBU3", "WBGene00016283", "Q21182", "WBGene00194737", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "A0A0K3ARD1", "WBGene00194737" ] }, "reaction_10535593": { "compartment": "compartment_984", "id": "reaction_10535593", "reactome": "R-CEL-1592297", "name": "Full activation of MMP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10535588" ], "products": [ "species_10534120" ], "modifiers": [ [ "species_10535590", "catalyst" ] ], "additional_components": [ "O62390", "WBGene00194737", "Q21182", "WBGene00194737", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "G5EBU3", "WBGene00016283", "Q21182", "WBGene00194737", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "A0A0K3ARD1", "WBGene00194737", "Q21182", "WBGene00194737", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737" ] }, "reaction_10536014": { "compartment": "compartment_17963", "id": "reaction_10536014", "reactome": "R-CEL-1602466", "name": "Activation of MT-MMPs by FURIN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10535950" ], "products": [ "species_10536012" ], "modifiers": [ [ "species_10510315", "catalyst" ] ], "additional_components": [ "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "Q21182", "WBGene00194737", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "Q21182", "WBGene00194737", "A0A0K3ARD1", "WBGene00194737", "WBGene00002232" ] }, "reaction_10536047": { "compartment": "compartment_17963", "id": "reaction_10536047", "reactome": "R-CEL-1602484", "name": "Activation of proMMP11 by FURIN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10536045" ], "products": [ "species_10534227" ], "modifiers": [ [ "species_10510315", "catalyst" ] ], "additional_components": [ "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "Q21182", "WBGene00194737", "Q21182", "WBGene00194737", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "WBGene00002232" ] }, "reaction_10536244": { "compartment": "compartment_984", "id": "reaction_10536244", "reactome": "R-CEL-1604732", "name": "Autocatalytic activation of proMMP13", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10536197" ], "products": [ "species_10534136", "species_10536241" ], "modifiers": [ [ "species_10536197", "catalyst" ], [ "species_10535571", "inhibitor" ] ], "additional_components": [ "Q21182", "WBGene00194737", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "Q21182", "WBGene00194737", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "Q21182", "WBGene00194737", "Q21182", "WBGene00194737", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "WBGene00000702" ] }, "reaction_10535573": { "compartment": "compartment_984", "id": "reaction_10535573", "reactome": "R-CEL-1592278", "name": "Autocatalytic activation of proMMP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10535551" ], "products": [ "species_10535565", "species_10534150" ], "modifiers": [ [ "species_10535551", "catalyst" ], [ "species_10535571", "inhibitor" ] ], "additional_components": [ "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "Q21182", "WBGene00194737", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "Q21182", "WBGene00194737", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "Q21182", "WBGene00194737", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "Q21182", "WBGene00194737", "WBGene00000702" ] }, "reaction_10536277": { "compartment": "compartment_984", "id": "reaction_10536277", "reactome": "R-CEL-1604741", "name": "Initial activation of proMMP13 by MMP14 (MT1-MMP)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10536061" ], "products": [ "species_10536181", "species_10536258" ], "modifiers": [ [ "species_10536274", "catalyst" ] ], "additional_components": [ "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "Q21182", "WBGene00194737", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "Q21182", "WBGene00194737", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "Q21182", "WBGene00194737", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283" ] }, "reaction_10536120": { "compartment": "compartment_984", "id": "reaction_10536120", "reactome": "R-CEL-1604359", "name": "Initial activation of proMMP2 by MMP1, 7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10536103" ], "products": [ "species_10535551", "species_10536117" ], "modifiers": [ [ "species_10534120", "catalyst" ] ], "additional_components": [ "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "Q21182", "WBGene00194737", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "Q21182", "WBGene00194737", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "G5EBU3", "WBGene00016283", "Q21182", "WBGene00194737", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "A0A0K3ARD1", "WBGene00194737" ] }, "reaction_10536312": { "compartment": "compartment_984", "id": "reaction_10536312", "reactome": "R-CEL-1604752", "name": "Initial activation of proMMP13 by MMP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10536061" ], "products": [ "species_10536291", "species_10536195" ], "modifiers": [ [ "species_10536309", "catalyst" ] ], "additional_components": [ "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "Q21182", "WBGene00194737", "Q21182", "WBGene00194737", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "Q21182", "WBGene00194737", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "Q93512", "WBGene00019986", "O45734", "WBGene00000776", "Q23030", "WBGene00019986", "O62390", "WBGene00194737", "Q21182", "WBGene00194737", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987" ] }, "reaction_10535774": { "compartment": "compartment_984", "id": "reaction_10535774", "reactome": "R-CEL-1592436", "name": "Initial activation of proMMP9 by MMPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10535741" ], "products": [ "species_10535755", "species_10535769" ], "modifiers": [ [ "species_10535771", "catalyst" ] ], "additional_components": [ "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "Q21182", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "Q21182", "WBGene00194737", "A0A0K3ARD1", "WBGene00194737", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "Q21182", "WBGene00194737", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "O62390", "WBGene00194737", "G5EBU3", "WBGene00016283", "Q21182", "WBGene00194737", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "A0A0K3ARD1", "WBGene00194737" ] }, "reaction_10536031": { "compartment": "compartment_984", "id": "reaction_10536031", "reactome": "R-CEL-1602473", "name": "Autocatalytic activation of MMP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10535621" ], "products": [ "species_10536028", "species_10535588" ], "modifiers": [ [ "species_10535621", "catalyst" ] ], "additional_components": [ "O62390", "WBGene00194737", "Q21182", "WBGene00194737", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "Q21182", "WBGene00194737", "O62390", "WBGene00194737", "Q21182", "WBGene00194737", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "Q21182", "WBGene00194737", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987" ] }, "reaction_10534261": { "compartment": "compartment_984", "id": "reaction_10534261", "reactome": "R-CEL-1454781", "name": "MMP1,3,13 (2, 7-12, 19) binding by Alpha-2 macroglubulin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10534199", "species_10534257" ], "products": [ "species_10534259" ], "modifiers": [], "additional_components": [ "K8F7Z5", "WBGene00008735", "Q7YTU0", "WBGene00013969", "O62390", "WBGene00194737", "Q21182", "WBGene00194737", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "Q21182", "WBGene00194737", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "K8F7Z5", "WBGene00008735", "Q7YTU0", "WBGene00013969" ] }, "reaction_10568695": { "compartment": "compartment_984", "id": "reaction_10568695", "reactome": "R-CEL-8942302", "name": "MMP13 cleaves OPTC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10568612" ], "products": [ "species_10568618", "species_10568692" ], "modifiers": [ [ "species_10534136", "catalyst" ] ], "additional_components": [ "WBGene00019351", "WBGene00019351", "WBGene00019351", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "Q21182", "WBGene00194737", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283" ] }, "reaction_10544776": { "compartment": "compartment_876", "id": "reaction_10544776", "reactome": "R-CEL-2533950", "name": "Fibronectin degradation by MMP14, TMPRSS6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10517394" ], "products": [ "species_10535515" ], "modifiers": [ [ "species_10534376", "catalyst" ] ], "additional_components": [ "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "Q21182", "WBGene00194737", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283" ] }, "reaction_10548232": { "compartment": "compartment_876", "id": "reaction_10548232", "reactome": "R-CEL-3788061", "name": "Fibronectin degradation by ADAM8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10517394" ], "products": [ "species_10548207" ], "modifiers": [ [ "species_10548229", "catalyst" ] ], "additional_components": [ "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769", "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q19844", "WBGene00270320", "A0A1D3PCM0", "WBGene00270320", "G5EDW5", "WBGene00000074", "G5EFD5", "WBGene00006804" ] }, "reaction_10535392": { "compartment": "compartment_984", "id": "reaction_10535392", "reactome": "R-CEL-1564164", "name": "Collagen type V degradation by MMP2,9,10", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10519175" ], "products": [ "species_10535387" ], "modifiers": [ [ "species_10535389", "catalyst" ] ], "additional_components": [ "O76368", "WBGene00000674", "Q09457", "WBGene00000251", "Q9N4U2", "WBGene00000647", "P17140", "WBGene00002280", "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689", "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689", "O76368", "WBGene00000674", "Q09457", "WBGene00000251", "Q9N4U2", "WBGene00000647", "P17140", "WBGene00002280", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "Q21182", "WBGene00194737" ] }, "reaction_10543302": { "compartment": "compartment_984", "id": "reaction_10543302", "reactome": "R-CEL-2168923", "name": "Collagen type XVIII endostatin release", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10543225" ], "products": [ "species_10543255", "species_10543253" ], "modifiers": [ [ "species_10543299", "catalyst" ] ], "additional_components": [ "Q19368", "WBGene00000702", "WBGene00000702", "Q19368", "WBGene00000702", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "Q21182", "WBGene00194737", "P43510", "WBGene00000786", "O45734", "WBGene00000776", "Q23030", "WBGene00019986", "Q93512", "WBGene00019986" ] }, "reaction_10535495": { "compartment": "compartment_984", "id": "reaction_10535495", "reactome": "R-CEL-1564169", "name": "Collagen type VIII degradation by MMP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10535492" ], "products": [ "species_10533894" ], "modifiers": [ [ "species_10534120", "catalyst" ] ], "additional_components": [ "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689", "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689", "O62390", "WBGene00194737", "G5EBU3", "WBGene00016283", "Q21182", "WBGene00194737", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "A0A0K3ARD1", "WBGene00194737" ] }, "reaction_10544552": { "compartment": "compartment_984", "id": "reaction_10544552", "reactome": "R-CEL-2471621", "name": "Endostatin degradation by cathepsins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10543255" ], "products": [], "modifiers": [ [ "species_10544549", "catalyst" ] ], "additional_components": [ "WBGene00000702", "P43510", "WBGene00000786", "O45734", "WBGene00000776", "Q23030", "WBGene00019986", "Q93512", "WBGene00019986", "Q21966", "WBGene00000217" ] }, "reaction_10557611": { "compartment": "compartment_5460", "id": "reaction_10557611", "reactome": "R-CEL-5696408", "name": "PXLP-K278-PHYKPL tetramer hydrolyses 5PHL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5696409", "species_113521" ], "products": [ "species_113548", "species_5693978", "species_113556" ], "modifiers": [ [ "species_10557608", "catalyst" ] ], "additional_components": [ "P91408", "WBGene00020139" ] }, "reaction_10534379": { "compartment": "compartment_984", "id": "reaction_10534379", "reactome": "R-CEL-1474210", "name": "Collagen type III degradation by MMP14", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10518945" ], "products": [ "species_10533696" ], "modifiers": [ [ "species_10534376", "catalyst" ] ], "additional_components": [ "Q9N4U2", "WBGene00000647", "O76368", "WBGene00000674", "Q09457", "WBGene00000251", "Q9N4U2", "WBGene00000647", "O76368", "WBGene00000674", "Q09457", "WBGene00000251", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "Q21182", "WBGene00194737", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283" ] }, "reaction_10534384": { "compartment": "compartment_984", "id": "reaction_10534384", "reactome": "R-CEL-1474213", "name": "Collagen type III degradation by MMP1,8,9,13", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10518945" ], "products": [ "species_10533696" ], "modifiers": [ [ "species_10534381", "catalyst" ] ], "additional_components": [ "Q9N4U2", "WBGene00000647", "O76368", "WBGene00000674", "Q09457", "WBGene00000251", "Q9N4U2", "WBGene00000647", "O76368", "WBGene00000674", "Q09457", "WBGene00000251", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "Q21182", "WBGene00194737" ] }, "reaction_10543312": { "compartment": "compartment_984", "id": "reaction_10543312", "reactome": "R-CEL-2172433", "name": "Collagen type XIX degradation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10542657" ], "products": [], "modifiers": [], "additional_components": [ "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689" ] }, "reaction_10544561": { "compartment": "compartment_984", "id": "reaction_10544561", "reactome": "R-CEL-2473584", "name": "Collagen type III degradation by MMP15", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10518945" ], "products": [ "species_10533696" ], "modifiers": [ [ "species_10536395", "catalyst" ] ], "additional_components": [ "Q9N4U2", "WBGene00000647", "O76368", "WBGene00000674", "Q09457", "WBGene00000251", "Q9N4U2", "WBGene00000647", "O76368", "WBGene00000674", "Q09457", "WBGene00000251", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "Q21182", "WBGene00194737", "A0A0K3ARD1", "WBGene00194737" ] }, "reaction_10544563": { "compartment": "compartment_876", "id": "reaction_10544563", "reactome": "R-CEL-2473594", "name": "Collagen type II degradation by MMP15", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10517286" ], "products": [ "species_10533498" ], "modifiers": [ [ "species_10536395", "catalyst" ] ], "additional_components": [ "O76368", "WBGene00000674", "Q09457", "WBGene00000251", "Q9N4U2", "WBGene00000647", "Q09457", "WBGene00000251", "Q9N4U2", "WBGene00000647", "O76368", "WBGene00000674", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "Q21182", "WBGene00194737", "A0A0K3ARD1", "WBGene00194737" ] }, "reaction_10544565": { "compartment": "compartment_876", "id": "reaction_10544565", "reactome": "R-CEL-2473596", "name": "Collagen type I degradation by MMP15", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509625" ], "products": [ "species_10533300" ], "modifiers": [ [ "species_10536395", "catalyst" ] ], "additional_components": [ "Q9N4U2", "WBGene00000647", "Q9N4U2", "WBGene00000647", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "Q21182", "WBGene00194737", "A0A0K3ARD1", "WBGene00194737" ] }, "reaction_10534197": { "compartment": "compartment_984", "id": "reaction_10534197", "reactome": "R-CEL-1454757", "name": "Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10534088" ], "products": [], "modifiers": [ [ "species_10534194", "catalyst" ] ], "additional_components": [ "Q9N4U2", "WBGene00000647", "O76368", "WBGene00000674", "Q09457", "WBGene00000251", "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "Q21182", "WBGene00194737" ] }, "reaction_10534266": { "compartment": "compartment_984", "id": "reaction_10534266", "reactome": "R-CEL-1454822", "name": "Collagen type I degradation by MMP1,2,8,13, PRSS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509625" ], "products": [ "species_10533300" ], "modifiers": [ [ "species_10534263", "catalyst" ] ], "additional_components": [ "Q9N4U2", "WBGene00000647", "Q9N4U2", "WBGene00000647", "Q21182", "WBGene00194737", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737" ] }, "reaction_10534362": { "compartment": "compartment_984", "id": "reaction_10534362", "reactome": "R-CEL-1474197", "name": "Collagen type II degradation by MMP1,3,8,13,PRSS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10517286" ], "products": [ "species_10533498" ], "modifiers": [ [ "species_10534359", "catalyst" ] ], "additional_components": [ "O76368", "WBGene00000674", "Q09457", "WBGene00000251", "Q9N4U2", "WBGene00000647", "Q09457", "WBGene00000251", "Q9N4U2", "WBGene00000647", "O76368", "WBGene00000674", "Q21182", "WBGene00194737", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737" ] }, "reaction_10543197": { "compartment": "compartment_876", "id": "reaction_10543197", "reactome": "R-CEL-2167942", "name": "Collagen type XIII ectodomain shedding", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10542932" ], "products": [ "species_10543195", "species_10543121" ], "modifiers": [], "additional_components": [ "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689", "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689", "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689" ] }, "reaction_10548284": { "compartment": "compartment_876", "id": "reaction_10548284", "reactome": "R-CEL-3791155", "name": "Laminin-322 degradation by MMP14", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10517354" ], "products": [ "species_10548282" ], "modifiers": [ [ "species_10534376", "catalyst" ] ], "additional_components": [ "O44565", "WBGene00002247", "Q18823", "WBGene00016913", "Q19981", "WBGene00006432", "G5EG68", "WBGene00018304", "Q06561", "WBGene00006787", "G5ECE3", "WBGene00002248", "Q21313", "WBGene00001328", "G5ECE3", "WBGene00002248", "Q21313", "WBGene00001328", "O44565", "WBGene00002247", "G5EG68", "WBGene00018304", "Q06561", "WBGene00006787", "Q18823", "WBGene00016913", "Q19981", "WBGene00006432", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "Q21182", "WBGene00194737", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283" ] }, "reaction_10568621": { "compartment": "compartment_984", "id": "reaction_10568621", "reactome": "R-CEL-8940554", "name": "MMP2 cleaves OPTC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10568612" ], "products": [ "species_10568618", "species_10568616", "species_10568614" ], "modifiers": [ [ "species_10534150", "catalyst" ] ], "additional_components": [ "WBGene00019351", "WBGene00019351", "WBGene00019351", "WBGene00019351", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "Q21182", "WBGene00194737", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646" ] }, "reaction_10511937": { "compartment": "compartment_7660", "id": "reaction_10511937", "reactome": "R-CEL-176318", "name": "Loading of claspin onto DNA during replication origin firing", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502234", "species_10511927" ], "products": [ "species_10511929" ], "modifiers": [], "additional_components": [ "Q7JMR0", "WBGene00009372", "O01493", "WBGene00016421", "Q9XX16", "WBGene00012651", "Q23249", "WBGene00013857", "Q9XX17", "WBGene00012650", "Q21037", "WBGene00003882", "P91155", "WBGene00000382", "O16297", "WBGene00003159", "Q95XQ8", "WBGene00003156", "Q9XXI9", "WBGene00003154", "Q21902", "WBGene00003157", "P34647", "WBGene00003158", "Q9XVR7", "WBGene00003155", "Q9U2C2", "WBGene00012935", "O61847", "WBGene00019362", "WBGene00009127", "O17838", "WBGene00009127", "Q7JMR0", "WBGene00009372", "O01493", "WBGene00016421", "Q9XX16", "WBGene00012651", "Q23249", "WBGene00013857", "Q9XX17", "WBGene00012650", "Q21037", "WBGene00003882", "P91155", "WBGene00000382", "O16297", "WBGene00003159", "Q95XQ8", "WBGene00003156", "Q9XXI9", "WBGene00003154", "Q21902", "WBGene00003157", "P34647", "WBGene00003158", "Q9XVR7", "WBGene00003155", "Q9U2C2", "WBGene00012935", "O61847", "WBGene00019362" ] }, "reaction_10511922": { "compartment": "compartment_7660", "id": "reaction_10511922", "reactome": "R-CEL-176264", "name": "Recruitment of the Rad9-Hus1-Rad1 complex to DNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10511917", "species_10511913" ], "products": [ "species_10511919" ], "modifiers": [ [ "species_10511917", "catalyst" ] ], "additional_components": [ "P53016", "WBGene00004340", "G5EGG2", "WBGene00001998", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "Q95Y97", "WBGene00019767", "G5EFI9", "WBGene00002042", "G5EC44", "WBGene00003417", "Q95Q27", "WBGene00001997", "G5EFI9", "WBGene00002042", "G5EC44", "WBGene00003417", "Q95Q27", "WBGene00001997", "P53016", "WBGene00004340", "G5EGG2", "WBGene00001998", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "Q95Y97", "WBGene00019767", "P53016", "WBGene00004340", "G5EGG2", "WBGene00001998", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "Q95Y97", "WBGene00019767" ] }, "reaction_10502791": { "compartment": "compartment_7660", "id": "reaction_10502791", "reactome": "R-CEL-69604", "name": "Phosphorylation of Cdc25A at Ser-123 by Chk1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10502759" ], "products": [ "species_113582", "species_10502781" ], "modifiers": [ [ "species_10502788", "catalyst" ] ], "additional_components": [ "WBGene00000389", "WBGene00000389", "WBGene00000498" ] }, "reaction_10507017": { "compartment": "compartment_7660", "id": "reaction_10507017", "reactome": "R-CEL-75010", "name": "Phosphorylation of Cdc25C at Ser 216 by Chk1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10507012" ], "products": [ "species_113582", "species_10507015" ], "modifiers": [ [ "species_10502788", "catalyst" ] ], "additional_components": [ "WBGene00000389", "WBGene00000389", "WBGene00000498" ] }, "reaction_10542996": { "compartment": "compartment_12045", "id": "reaction_10542996", "reactome": "R-CEL-2161890", "name": "Arachidonic acid is epoxidated to 5,6-EET by CYP(4)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29368", "species_29768", "species_29364" ], "products": [ "species_29356", "species_29366", "species_2142739" ], "modifiers": [ [ "species_10507902", "catalyst" ] ], "additional_components": [ "O45659", "WBGene00010589", "O61204", "WBGene00015045", "O61935", "WBGene00020386", "O62377", "WBGene00011699", "O62378", "WBGene00011698", "P90771", "WBGene00007913", "Q20315", "WBGene00018333", "A0A0M7RF98", "WBGene00018264", "Q27465", "WBGene00015135", "G5ECD0", "WBGene00007362", "Q27470", "WBGene00015709", "G5EE22", "WBGene00012448", "Q27471", "WBGene00016092", "H2KY69", "WBGene00015044", "Q27482", "WBGene00016768", "H2KYS3", "WBGene00000905", "Q27499", "WBGene00018334", "O02627", "WBGene00015399", "Q965T7", "WBGene00021710", "O02628", "WBGene00015400", "Q9N4Q4", "WBGene00021168", "O02641", "WBGene00019967", "Q9N5I1", "WBGene00019565", "O16220", "WBGene00016786", "O16362", "WBGene00018413", "O16482", "WBGene00016860", "O16670", "WBGene00018262", "O16671", "WBGene00018261", "O16673", "WBGene00018260", "O44649", "WBGene00019473", "O44650", "WBGene00019472", "O44651", "WBGene00019471", "O44652", "WBGene00019470", "O44655", "WBGene00015040", "O44656", "WBGene00015041", "O44657", "WBGene00015042", "O44658", "WBGene00015043", "O44704", "WBGene00016686", "O44706", "WBGene00016697", "O45364", "WBGene00008829" ] }, "reaction_10542998": { "compartment": "compartment_12045", "id": "reaction_10542998", "reactome": "R-CEL-2161899", "name": "Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29368", "species_29768", "species_29364" ], "products": [ "species_29356", "species_2161753", "species_29366" ], "modifiers": [ [ "species_10507902", "catalyst" ] ], "additional_components": [ "CHEBI:34130", "CHEBI:34490", "CHEBI:34157", "O45659", "WBGene00010589", "O61204", "WBGene00015045", "O61935", "WBGene00020386", "O62377", "WBGene00011699", "O62378", "WBGene00011698", "P90771", "WBGene00007913", "Q20315", "WBGene00018333", "A0A0M7RF98", "WBGene00018264", "Q27465", "WBGene00015135", "G5ECD0", "WBGene00007362", "Q27470", "WBGene00015709", "G5EE22", "WBGene00012448", "Q27471", "WBGene00016092", "H2KY69", "WBGene00015044", "Q27482", "WBGene00016768", "H2KYS3", "WBGene00000905", "Q27499", "WBGene00018334", "O02627", "WBGene00015399", "Q965T7", "WBGene00021710", "O02628", "WBGene00015400", "Q9N4Q4", "WBGene00021168", "O02641", "WBGene00019967", "Q9N5I1", "WBGene00019565", "O16220", "WBGene00016786", "O16362", "WBGene00018413", "O16482", "WBGene00016860", "O16670", "WBGene00018262", "O16671", "WBGene00018261", "O16673", "WBGene00018260", "O44649", "WBGene00019473", "O44650", "WBGene00019472", "O44651", "WBGene00019471", "O44652", "WBGene00019470", "O44655", "WBGene00015040", "O44656", "WBGene00015041", "O44657", "WBGene00015042", "O44658", "WBGene00015043", "O44704", "WBGene00016686", "O44706", "WBGene00016697", "O45364", "WBGene00008829" ] }, "reaction_10519552": { "compartment": "compartment_70101", "id": "reaction_10519552", "reactome": "R-CEL-377644", "name": "Release of CSK from SRC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10519544" ], "products": [ "species_10518223", "species_10519550" ], "modifiers": [], "additional_components": [ "species_74016", "species_266099", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "G5ECJ6", "WBGene00000812", "P34446", "WBGene00003929", "G5EGK1", "WBGene00006771", "species_179856", "Q18246", "WBGene00004307", "species_29438", "P34400", "WBGene00003243", "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769", "WBGene00000812", "species_74016", "species_266099", "G5EGK1", "WBGene00006771", "species_179856", "Q18246", "WBGene00004307", "species_29438", "P34400", "WBGene00003243", "P34446", "WBGene00003929", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769" ] }, "reaction_10518244": { "compartment": "compartment_70101", "id": "reaction_10518244", "reactome": "R-CEL-354087", "name": "Recruitment of GRB2 to p-PTK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10506871", "species_10518240" ], "products": [ "species_10518242" ], "modifiers": [], "additional_components": [ "WBGene00004774", "species_74016", "species_266099", "G5EGK1", "WBGene00006771", "species_179856", "Q18246", "WBGene00004307", "species_29438", "P34400", "WBGene00003243", "P34446", "WBGene00003929", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769", "Q95YD4", "WBGene00002213", "species_74016", "species_266099", "G5EGK1", "WBGene00006771", "species_179856", "Q18246", "WBGene00004307", "species_29438", "P34400", "WBGene00003243", "P34446", "WBGene00003929", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769", "Q95YD4", "WBGene00002213", "P29355", "WBGene00004774" ] }, "reaction_10518263": { "compartment": "compartment_70101", "id": "reaction_10518263", "reactome": "R-CEL-354165", "name": "Interaction of SOS with GRB2 bound to FADK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10506876", "species_10518242" ], "products": [ "species_10518261" ], "modifiers": [], "additional_components": [ "WBGene00004947", "species_74016", "species_266099", "G5EGK1", "WBGene00006771", "species_179856", "Q18246", "WBGene00004307", "species_29438", "P34400", "WBGene00003243", "P34446", "WBGene00003929", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769", "Q95YD4", "WBGene00002213", "P29355", "WBGene00004774", "species_74016", "species_266099", "G5EGK1", "WBGene00006771", "species_179856", "Q18246", "WBGene00004307", "species_29438", "P34400", "WBGene00003243", "P34446", "WBGene00003929", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769", "Q95YD4", "WBGene00002213", "P29355", "WBGene00004774", "Q9N5D3", "WBGene00004947" ] }, "reaction_10518210": { "compartment": "compartment_70101", "id": "reaction_10518210", "reactome": "R-CEL-354073", "name": "Autophosphorylation of PTK2 at Y397", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10518200" ], "products": [ "species_10518207", "species_29370" ], "modifiers": [ [ "species_10518200", "catalyst" ] ], "additional_components": [ "species_74016", "species_266099", "G5EGK1", "WBGene00006771", "species_179856", "Q18246", "WBGene00004307", "species_29438", "P34400", "WBGene00003243", "P34446", "WBGene00003929", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769", "Q95YD4", "WBGene00002213", "species_74016", "species_266099", "G5EGK1", "WBGene00006771", "species_179856", "Q18246", "WBGene00004307", "species_29438", "P34400", "WBGene00003243", "P34446", "WBGene00003929", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769", "Q95YD4", "WBGene00002213", "species_74016", "species_266099", "G5EGK1", "WBGene00006771", "species_179856", "Q18246", "WBGene00004307", "species_29438", "P34400", "WBGene00003243", "P34446", "WBGene00003929", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769", "Q95YD4", "WBGene00002213" ] }, "reaction_10518277": { "compartment": "compartment_70101", "id": "reaction_10518277", "reactome": "R-CEL-354173", "name": "Activation of Rap1 by cytosolic GEFs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10518265" ], "products": [ "species_29420", "species_10518164" ], "modifiers": [ [ "species_10518274", "catalyst" ] ], "additional_components": [ "Q18246", "WBGene00004307", "species_29420", "Q18246", "WBGene00004307", "species_29438", "species_74016", "species_114519", "Q19770", "WBGene00009100" ] }, "reaction_10518246": { "compartment": "compartment_70101", "id": "reaction_10518246", "reactome": "R-CEL-354097", "name": "Activation of Talin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10518171", "species_10518194" ], "products": [ "species_10518196" ], "modifiers": [], "additional_components": [ "species_179856", "Q18246", "WBGene00004307", "species_29438", "P34400", "WBGene00003243", "WBGene00006771", "G5EGK1", "WBGene00006771", "species_179856", "Q18246", "WBGene00004307", "species_29438", "P34400", "WBGene00003243" ] }, "reaction_10523400": { "compartment": "compartment_70101", "id": "reaction_10523400", "reactome": "R-CEL-429415", "name": "SYK binds to integrin alphaIIb beta3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10516474", "species_10518198" ], "products": [ "species_10523398" ], "modifiers": [], "additional_components": [ "WBGene00016416", "species_74016", "species_266099", "G5EGK1", "WBGene00006771", "species_179856", "Q18246", "WBGene00004307", "species_29438", "P34400", "WBGene00003243", "P34446", "WBGene00003929", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769", "species_74016", "species_266099", "G5EGK1", "WBGene00006771", "species_179856", "Q18246", "WBGene00004307", "species_29438", "P34400", "WBGene00003243", "P34446", "WBGene00003929", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769", "Q18462", "WBGene00016416" ] }, "reaction_10518255": { "compartment": "compartment_70101", "id": "reaction_10518255", "reactome": "R-CEL-354124", "name": "Phosphorylation of pPTK2 by SRC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10518207", "species_113592" ], "products": [ "species_29370", "species_10518240" ], "modifiers": [ [ "species_10518207", "catalyst" ] ], "additional_components": [ "species_74016", "species_266099", "G5EGK1", "WBGene00006771", "species_179856", "Q18246", "WBGene00004307", "species_29438", "P34400", "WBGene00003243", "P34446", "WBGene00003929", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769", "Q95YD4", "WBGene00002213", "species_74016", "species_266099", "G5EGK1", "WBGene00006771", "species_179856", "Q18246", "WBGene00004307", "species_29438", "P34400", "WBGene00003243", "P34446", "WBGene00003929", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769", "Q95YD4", "WBGene00002213", "species_74016", "species_266099", "G5EGK1", "WBGene00006771", "species_179856", "Q18246", "WBGene00004307", "species_29438", "P34400", "WBGene00003243", "P34446", "WBGene00003929", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769", "Q95YD4", "WBGene00002213" ] }, "reaction_10523408": { "compartment": "compartment_70101", "id": "reaction_10523408", "reactome": "R-CEL-429441", "name": "SYK activation by SRC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10523398" ], "products": [ "species_10523405", "species_29370" ], "modifiers": [ [ "species_10523398", "catalyst" ] ], "additional_components": [ "species_74016", "species_266099", "G5EGK1", "WBGene00006771", "species_179856", "Q18246", "WBGene00004307", "species_29438", "P34400", "WBGene00003243", "P34446", "WBGene00003929", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769", "Q18462", "WBGene00016416", "species_74016", "species_266099", "G5EGK1", "WBGene00006771", "species_179856", "Q18246", "WBGene00004307", "species_29438", "P34400", "WBGene00003243", "P34446", "WBGene00003929", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769", "Q18462", "WBGene00016416", "species_74016", "species_266099", "G5EGK1", "WBGene00006771", "species_179856", "Q18246", "WBGene00004307", "species_29438", "P34400", "WBGene00003243", "P34446", "WBGene00003929", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769", "Q18462", "WBGene00016416" ] }, "reaction_10529458": { "compartment": "compartment_70101", "id": "reaction_10529458", "reactome": "R-CEL-939265", "name": "Activation of Rap1 by membrane-associated GEFs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10518265" ], "products": [ "species_29420", "species_10518164" ], "modifiers": [ [ "species_10520078", "catalyst" ] ], "additional_components": [ "Q18246", "WBGene00004307", "species_29420", "Q18246", "WBGene00004307", "species_29438", "WBGene00004255" ] }, "reaction_10518259": { "compartment": "compartment_984", "id": "reaction_10518259", "reactome": "R-CEL-354149", "name": "Interaction of integrin alphaIIb beta3 with Fibrinogen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10515311", "species_10518229", "species_377604" ], "products": [ "species_10518257" ], "modifiers": [], "additional_components": [ "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "G5ECJ6", "WBGene00000812", "P34446", "WBGene00003929", "G5EGK1", "WBGene00006771", "species_179856", "Q18246", "WBGene00004307", "species_29438", "P34400", "WBGene00003243", "species_74016", "species_266099", "species_74016", "species_266099", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "G5ECJ6", "WBGene00000812", "P34446", "WBGene00003929", "G5EGK1", "WBGene00006771", "species_179856", "Q18246", "WBGene00004307", "species_29438", "P34400", "WBGene00003243", "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769" ] }, "reaction_10519542": { "compartment": "compartment_70101", "id": "reaction_10519542", "reactome": "R-CEL-377640", "name": "Autophosphorylation of SRC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10519539" ], "products": [ "species_29370", "species_10518198" ], "modifiers": [ [ "species_10513079", "catalyst" ] ], "additional_components": [ "species_74016", "species_266099", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "P34446", "WBGene00003929", "G5EGK1", "WBGene00006771", "species_179856", "Q18246", "WBGene00004307", "species_29438", "P34400", "WBGene00003243", "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769", "species_74016", "species_266099", "G5EGK1", "WBGene00006771", "species_179856", "Q18246", "WBGene00004307", "species_29438", "P34400", "WBGene00003243", "P34446", "WBGene00003929", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635" ] }, "reaction_10518231": { "compartment": "compartment_876", "id": "reaction_10518231", "reactome": "R-CEL-354077", "name": "Integrin alphaIIb beta3 activation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10518196", "species_10518227" ], "products": [ "species_10518229" ], "modifiers": [], "additional_components": [ "G5EGK1", "WBGene00006771", "species_179856", "Q18246", "WBGene00004307", "species_29438", "P34400", "WBGene00003243", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "G5ECJ6", "WBGene00000812", "P34446", "WBGene00003929", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "G5ECJ6", "WBGene00000812", "P34446", "WBGene00003929", "G5EGK1", "WBGene00006771", "species_179856", "Q18246", "WBGene00004307", "species_29438", "P34400", "WBGene00003243" ] }, "reaction_10519546": { "compartment": "compartment_876", "id": "reaction_10519546", "reactome": "R-CEL-377641", "name": "Clustering of Integrin alphaIIb beta3 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10518227", "species_10518257" ], "products": [ "species_10519544" ], "modifiers": [], "additional_components": [ "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "G5ECJ6", "WBGene00000812", "P34446", "WBGene00003929", "species_74016", "species_266099", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "G5ECJ6", "WBGene00000812", "P34446", "WBGene00003929", "G5EGK1", "WBGene00006771", "species_179856", "Q18246", "WBGene00004307", "species_29438", "P34400", "WBGene00003243", "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769", "species_74016", "species_266099", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "G5ECJ6", "WBGene00000812", "P34446", "WBGene00003929", "G5EGK1", "WBGene00006771", "species_179856", "Q18246", "WBGene00004307", "species_29438", "P34400", "WBGene00003243", "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769" ] }, "reaction_10518202": { "compartment": "compartment_70101", "id": "reaction_10518202", "reactome": "R-CEL-354066", "name": "Translocation of PTK2 to Focal complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10514906", "species_10518198" ], "products": [ "species_10518200" ], "modifiers": [], "additional_components": [ "WBGene00002213", "species_74016", "species_266099", "G5EGK1", "WBGene00006771", "species_179856", "Q18246", "WBGene00004307", "species_29438", "P34400", "WBGene00003243", "P34446", "WBGene00003929", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769", "species_74016", "species_266099", "G5EGK1", "WBGene00006771", "species_179856", "Q18246", "WBGene00004307", "species_29438", "P34400", "WBGene00003243", "P34446", "WBGene00003929", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769", "Q95YD4", "WBGene00002213" ] }, "reaction_10524570": { "compartment": "compartment_876", "id": "reaction_10524570", "reactome": "R-CEL-443905", "name": "SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10524564" ], "products": [ "species_10524568" ], "modifiers": [], "additional_components": [ "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "G5ECJ6", "WBGene00000812", "P34446", "WBGene00003929", "G5EGK1", "WBGene00006771", "species_179856", "Q18246", "WBGene00004307", "species_29438", "P34400", "WBGene00003243", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "G5ECJ6", "WBGene00000812", "P34446", "WBGene00003929", "G5EGK1", "WBGene00006771", "species_179856", "Q18246", "WBGene00004307", "species_29438", "P34400", "WBGene00003243" ] }, "reaction_10518173": { "compartment": "compartment_70101", "id": "reaction_10518173", "reactome": "R-CEL-354060", "name": "Translocation of RIAM to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10518169", "species_10518164", "species_179856" ], "products": [ "species_10518171" ], "modifiers": [], "additional_components": [ "WBGene00003243", "Q18246", "WBGene00004307", "species_29438", "species_179856", "Q18246", "WBGene00004307", "species_29438", "P34400", "WBGene00003243" ] }, "reaction_10503824": { "compartment": "compartment_70101", "id": "reaction_10503824", "reactome": "R-CEL-71188", "name": "TDO tetramer dioxygenates L-Trp to NFK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29500", "species_29368" ], "products": [ "species_33179" ], "modifiers": [ [ "species_10503821", "catalyst" ] ], "additional_components": [ "species_71185", "Q09474", "WBGene00016201" ] }, "reaction_10503843": { "compartment": "compartment_70101", "id": "reaction_10503843", "reactome": "R-CEL-71217", "name": "3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_34351", "species_29356" ], "products": [ "species_29432", "species_30487" ], "modifiers": [ [ "species_10503840", "catalyst" ] ], "additional_components": [ "Q18026", "WBGene00015802" ] }, "reaction_10503832": { "compartment": "compartment_70101", "id": "reaction_10503832", "reactome": "R-CEL-71200", "name": "kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29368", "species_29364", "species_29970" ], "products": [ "species_34351", "species_29356", "species_29366" ], "modifiers": [ [ "species_10503829", "catalyst" ] ], "additional_components": [ "WBGene00011089" ] }, "reaction_10528412": { "compartment": "compartment_70101", "id": "reaction_10528412", "reactome": "R-CEL-893596", "name": "PXLP-KYAT1 dimer transaminates L-KYN to AP-DOBu", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29398", "species_29970" ], "products": [ "species_29432", "species_893615" ], "modifiers": [ [ "species_10528406", "catalyst" ], [ "species_29502", "inhibitor" ], [ "species_8939576", "inhibitor" ] ], "additional_components": [ "Q9XX97", "WBGene00009232", "Q8MP09", "WBGene00010984", "CHEBI:55528", "CHEBI:43580" ] }, "reaction_10503853": { "compartment": "compartment_70101", "id": "reaction_10503853", "reactome": "R-CEL-71218", "name": "3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_30487" ], "products": [ "species_36027" ], "modifiers": [ [ "species_10503850", "catalyst" ] ], "additional_components": [ "Q19341", "WBGene00010595", "species_113531" ] }, "reaction_10566750": { "compartment": "compartment_876", "id": "reaction_10566750", "reactome": "R-CEL-8870352", "name": "SLC36A4 transports L-Trp from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352006" ], "products": [ "species_29500" ], "modifiers": [ [ "species_10566747", "catalyst" ] ], "additional_components": [ "O45936", "WBGene00012804", "O62286", "WBGene00010421", "P34479", "WBGene00010307", "Q18595", "WBGene00016628", "Q9XX44", "WBGene00012629", "G4SQY7", "WBGene00020837" ] }, "reaction_10542434": { "compartment": "compartment_17951", "id": "reaction_10542434", "reactome": "R-CEL-2066778", "name": "Hydration of delta2-tetracosaheptaenoyl-CoA to 3-hydroxy tetracosahexaenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_141343", "species_2066767" ], "products": [ "species_2066766" ], "modifiers": [ [ "species_10513270", "catalyst" ] ], "additional_components": [ "Q19058", "WBGene00017123" ] }, "reaction_10542291": { "compartment": "compartment_12045", "id": "reaction_10542291", "reactome": "R-CEL-2046084", "name": "Desaturation of alpha-linoleoyl-CoA to Stearidonoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_194697", "species_2046062" ], "products": [ "species_194653", "species_113519", "species_2046052" ], "modifiers": [ [ "species_10542288", "catalyst" ] ], "additional_components": [ "WBGene00001395" ] }, "reaction_10542308": { "compartment": "compartment_17957", "id": "reaction_10542308", "reactome": "R-CEL-2046089", "name": "Desaturation of eicosatetraenoyl-CoA to eicosapentaenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_2046051", "species_194697" ], "products": [ "species_194653", "species_113519", "species_2046059" ], "modifiers": [ [ "species_10542305", "catalyst" ] ], "additional_components": [ "G5EG11", "WBGene00001396", "Q23221", "WBGene00001395" ] }, "reaction_10542436": { "compartment": "compartment_17951", "id": "reaction_10542436", "reactome": "R-CEL-2066779", "name": "Conversion of DHA-CoA to docosahexaenoic acid (DHA)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_141343", "species_2066765" ], "products": [ "species_193514", "species_2066763" ], "modifiers": [ [ "species_10513389", "catalyst" ] ], "additional_components": [ "WBGene00015887" ] }, "reaction_10542294": { "compartment": "compartment_17957", "id": "reaction_10542294", "reactome": "R-CEL-2046087", "name": "Translocation of tetracosahexaenoyl-CoA to peroxisomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2046054", "species_211579" ], "products": [ "species_426639", "species_211606", "species_2046047" ], "modifiers": [ [ "species_10520379", "catalyst" ] ], "additional_components": [ "WBGene00004061" ] }, "reaction_10542438": { "compartment": "compartment_17951", "id": "reaction_10542438", "reactome": "R-CEL-2066780", "name": "Dehydrogenation of 3-hydroxy tetracosahexaenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2066766" ], "products": [ "species_2066762" ], "modifiers": [ [ "species_10513270", "catalyst" ] ], "additional_components": [ "Q19058", "WBGene00017123" ] }, "reaction_10542296": { "compartment": "compartment_17957", "id": "reaction_10542296", "reactome": "R-CEL-2046088", "name": "Elongation of stearidonoyl-CoA to eicosatetraenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2046066", "species_2046052", "species_113601" ], "products": [ "species_113519", "species_113564", "species_2046051", "species_162743", "species_159751" ], "modifiers": [ [ "species_10527261", "catalyst" ] ], "additional_components": [ "WBGene00001241" ] }, "reaction_10542440": { "compartment": "compartment_17951", "id": "reaction_10542440", "reactome": "R-CEL-2066787", "name": "Oxidation of tetracosapentaenoyl-CoA to delta2-tetracosaheptaenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113535", "species_2046047" ], "products": [ "species_113575", "species_2066767" ], "modifiers": [ [ "species_10520766", "catalyst" ] ], "additional_components": [ "species_113596", "O62138", "WBGene00008566" ] }, "reaction_10567994": { "compartment": "compartment_70101", "id": "reaction_10567994", "reactome": "R-CEL-8932355", "name": "26S proteasome degrades Ub-NFE2L2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10567992" ], "products": [ "species_10502375" ], "modifiers": [ [ "species_10502572", "catalyst" ] ], "additional_components": [ "P34707", "WBGene00004804", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "P91477", "WBGene00003950", "Q95PZ7", "WBGene00013435", "Q18115", "WBGene00004459", "O62102", "WBGene00003948", "O17071", "WBGene00004504", "Q10920", "WBGene00016623", "P34286", "WBGene00003952", "Q9XTT9", "WBGene00004506", "Q23449", "WBGene00004468", "Q95005", "WBGene00003925", "P46502", "WBGene00004503", "O61792", "WBGene00004464", "O17586", "WBGene00003922", "O76371", "WBGene00004505", "Q20585", "WBGene00004463", "Q95008", "WBGene00003926", "Q18787", "WBGene00004501", "Q20058", "WBGene00009445", "Q9N599", "WBGene00003924", "O16368", "WBGene00004502", "O61742", "WBGene00004466", "Q09583", "WBGene00003928", "Q966I8", "WBGene00003947", "Q04908", "WBGene00004460", "Q9XUV0", "WBGene00003951", "Q27488", "WBGene00003923", "Q9GZH5", "WBGene00004458", "O44156", "WBGene00003927", "Q22253", "WBGene00004465", "O76577", "WBGene00004467", "P90868", "WBGene00003953", "Q19324", "WBGene00004461", "Q17971", "WBGene00007588", "Q23237", "WBGene00003949", "Q20938", "WBGene00004462" ] }, "reaction_10573338": { "compartment": "compartment_70101", "id": "reaction_10573338", "reactome": "R-CEL-9712274", "name": "NFE2L2 inducers bind to KEAP1:CUL3:RBX1:NFE2L2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10567990", "species_9714134" ], "products": [ "species_10573336" ], "modifiers": [], "additional_components": [ "P34707", "WBGene00004804", "Q23457", "WBGene00004320", "Q17391", "WBGene00000838", "P34707", "WBGene00004804", "Q23457", "WBGene00004320", "Q17391", "WBGene00000838" ] }, "reaction_10567982": { "compartment": "compartment_70101", "id": "reaction_10567982", "reactome": "R-CEL-8932309", "name": "NFE2L2 translocates from cytosol to nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10567974" ], "products": [ "species_10567980" ], "modifiers": [], "additional_components": [] }, "reaction_10553087": { "compartment": "compartment_876", "id": "reaction_10553087", "reactome": "R-CEL-5621363", "name": "SYK phosphorylates PLCG2 in p-6Y-SYK:p-Y65,Y76-FCER1G:PLCG2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10553084", "species_113592" ], "products": [ "species_10553082", "species_29370" ], "modifiers": [ [ "species_10553084", "catalyst" ] ], "additional_components": [ "Q22070", "WBGene00004038", "Q18462", "WBGene00016416", "Q22070", "WBGene00004038", "Q18462", "WBGene00016416", "Q22070", "WBGene00004038", "Q18462", "WBGene00016416" ] }, "reaction_10565886": { "compartment": "compartment_876", "id": "reaction_10565886", "reactome": "R-CEL-8858500", "name": "CLEC10A binds Tn-MUC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10565882", "species_10565876" ], "products": [ "species_10565884" ], "modifiers": [], "additional_components": [ "Q9U2D6", "WBGene00012901", "P34501", "WBGene00010540", "Q9N4W4", "WBGene00021602", "Q9N4W5", "WBGene00021603", "O18076", "WBGene00011668", "O44871", "WBGene00019914", "P91214", "WBGene00017199", "Q21146", "WBGene00019328", "Q9N4W4", "WBGene00021602", "Q9N4W5", "WBGene00021603", "O18076", "WBGene00011668", "O44871", "WBGene00019914", "P91214", "WBGene00017199", "Q21146", "WBGene00019328", "Q9U2D6", "WBGene00012901", "P34501", "WBGene00010540" ] }, "reaction_10531875": { "compartment": "compartment_20699", "id": "reaction_10531875", "reactome": "R-CEL-1028788", "name": "FUT8 transfers fucosyl group from GDP-Fuc to GlcNAc of NGP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_975910", "species_205683" ], "products": [ "species_205689", "species_1028779" ], "modifiers": [ [ "species_10531872", "catalyst" ] ], "additional_components": [ "WBGene00001508" ] }, "reaction_10530580": { "compartment": "compartment_20699", "id": "reaction_10530580", "reactome": "R-CEL-975814", "name": "Trimming of mannoses on the alpha1,6 arm by MAN2A1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_964837" ], "products": [ "species_964752", "species_975819" ], "modifiers": [ [ "species_10530577", "catalyst" ] ], "additional_components": [ "species_216785", "Q2PJ74", "WBGene00010284" ] }, "reaction_10557159": { "compartment": "compartment_17963", "id": "reaction_10557159", "reactome": "R-CEL-5693925", "name": "FUT3 transfers L-fucose to Gal1,3GlcNAc", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5693930", "species_205683" ], "products": [ "species_5693933", "species_205689" ], "modifiers": [ [ "species_10557156", "catalyst" ] ], "additional_components": [ "WBGene00016163" ] }, "reaction_10530588": { "compartment": "compartment_20699", "id": "reaction_10530588", "reactome": "R-CEL-975829", "name": "Addition of a GlcNAc on the alpha 1,4 branch by MGAT2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_914003", "species_975819" ], "products": [ "species_205687", "species_975822" ], "modifiers": [ [ "species_10530585", "catalyst" ] ], "additional_components": [ "WBGene00001645" ] }, "reaction_10557151": { "compartment": "compartment_161320", "id": "reaction_10557151", "reactome": "R-CEL-5693807", "name": "FUCA1 hydrolyses NGP:1,6-GlcNAc", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_6784247" ], "products": [ "species_6784248", "species_6784249" ], "modifiers": [ [ "species_10557148", "catalyst" ] ], "additional_components": [ "P49713", "WBGene00012225" ] }, "reaction_10502093": { "compartment": "compartment_7660", "id": "reaction_10502093", "reactome": "R-CEL-68637", "name": "CDC6 protein is synthesized under the control of E2F transcription factors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [], "products": [ "species_10502084" ], "modifiers": [ [ "species_10502089", "catalyst" ] ], "additional_components": [ "WBGene00000382", "WBGene00001162" ] }, "reaction_10508790": { "compartment": "compartment_7660", "id": "reaction_10508790", "reactome": "R-CEL-110349", "name": "Displacement of UNG glycosylase by APEX1 at the AP site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508670", "species_10508786" ], "products": [ "species_10508664", "species_10508788" ], "modifiers": [], "additional_components": [ "Q9U221", "WBGene00013241", "WBGene00001372", "WBGene00013241", "G5EBR7", "WBGene00001372" ] }, "reaction_10508792": { "compartment": "compartment_7660", "id": "reaction_10508792", "reactome": "R-CEL-110352", "name": "Displacement of NTHL1 glycosylase by APEX1 at the AP site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508686", "species_10508786" ], "products": [ "species_10508788", "species_10508657" ], "modifiers": [], "additional_components": [ "P54137", "WBGene00011201", "WBGene00001372", "G5EBR7", "WBGene00001372", "WBGene00011201" ] }, "reaction_10529620": { "compartment": "compartment_20699", "id": "reaction_10529620", "reactome": "R-CEL-964825", "name": "Progressive trimming of alpha-1,2-linked mannose residues from Man8GlcNAc2 to produce Man5GlcNAc2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_964831" ], "products": [ "species_964752", "species_964740" ], "modifiers": [ [ "species_10529593", "catalyst" ] ], "additional_components": [ "CHEBI:60629", "CHEBI:60628", "CHEBI:60627", "P90787", "WBGene00008411", "Q18788", "WBGene00008258" ] }, "reaction_10529622": { "compartment": "compartment_20699", "id": "reaction_10529622", "reactome": "R-CEL-964830", "name": "Progressive trimming of alpha-1,2-linked mannose residues from Man7GlcNAc2 to produce Man5GlcNAc2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_964828" ], "products": [ "species_964752", "species_964740" ], "modifiers": [ [ "species_10529593", "catalyst" ] ], "additional_components": [ "P90787", "WBGene00008411", "Q18788", "WBGene00008258" ] }, "reaction_10529596": { "compartment": "compartment_20699", "id": "reaction_10529596", "reactome": "R-CEL-964737", "name": "Progressive trimming of alpha-1,2-linked mannose residues from Man9GlcNAc2 to produce Man5GlcNAc2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_915149" ], "products": [ "species_964752", "species_964740" ], "modifiers": [ [ "species_10529593", "catalyst" ] ], "additional_components": [ "P90787", "WBGene00008411", "Q18788", "WBGene00008258" ] }, "reaction_10568853": { "compartment": "compartment_70101", "id": "reaction_10568853", "reactome": "R-CEL-8948757", "name": "AKT phosphorylates MKRN1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10531086", "species_113592" ], "products": [ "species_29370", "species_10568851" ], "modifiers": [ [ "species_10513848", "catalyst" ] ], "additional_components": [ "WBGene00002278", "WBGene00002278", "Q9XTG7", "WBGene00000103", "G4S4W1", "WBGene00016980", "Q17941", "WBGene00000102" ] }, "reaction_10513917": { "compartment": "compartment_70101", "id": "reaction_10513917", "reactome": "R-CEL-198621", "name": "AKT phosphorylates caspase-9", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10509443" ], "products": [ "species_10513915", "species_29370" ], "modifiers": [ [ "species_10513848", "catalyst" ] ], "additional_components": [ "P42573", "WBGene00000417", "G5EBM1", "WBGene00000819", "G5EBM1", "WBGene00000819", "P42573", "WBGene00000417", "Q9XTG7", "WBGene00000103", "G4S4W1", "WBGene00016980", "Q17941", "WBGene00000102" ] }, "reaction_10523796": { "compartment": "compartment_876", "id": "reaction_10523796", "reactome": "R-CEL-432049", "name": "Aquaporin-9 passively transports glycerol into cell", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_192438" ], "products": [ "species_76116" ], "modifiers": [ [ "species_10523793", "catalyst" ] ], "additional_components": [ "Q7YWQ1", "WBGene00013272", "Q17571", "WBGene00000170", "Q7Z138", "WBGene00000176", "Q19949", "WBGene00000169", "Q9XW36", "WBGene00000171", "Q21473", "WBGene00000175" ] }, "reaction_10523803": { "compartment": "compartment_876", "id": "reaction_10523803", "reactome": "R-CEL-432074", "name": "Aquaporin-7 passively transports glycerol out of cell", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76116" ], "products": [ "species_192438" ], "modifiers": [ [ "species_10523800", "catalyst" ] ], "additional_components": [ "Q9XW36", "WBGene00000171" ] }, "reaction_10530450": { "compartment": "compartment_876", "id": "reaction_10530450", "reactome": "R-CEL-975389", "name": "GLRA:GLRB:Gly transports extracellular Cl- to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_188972" ], "products": [ "species_352022" ], "modifiers": [ [ "species_10530447", "catalyst" ] ], "additional_components": [ "species_159549", "G5EBR3", "WBGene00001591", "Q95QT7", "WBGene00001594", "G5ECH3", "WBGene00000233", "Q95Y52", "WBGene00022106", "G5EDN0", "WBGene00018880", "Q9GQ00", "WBGene00003386", "G5EEC1", "WBGene00013746", "Q9NA62", "WBGene00013517", "G5EEX8", "WBGene00009799", "Q9U358", "WBGene00012099", "G5EEZ3", "WBGene00001593", "X5LVB0", "WBGene00017399", "H2KYN9", "WBGene00020657", "O17041", "WBGene00020528", "P41849", "WBGene00020605", "P91985", "WBGene00008223", "Q10052", "WBGene00001588", "Q17328", "WBGene00001592", "Q18812", "WBGene00008280", "Q21005", "WBGene00010275", "Q21420", "WBGene00010741", "Q95Q97", "WBGene00000232" ] }, "reaction_10572690": { "compartment": "compartment_876", "id": "reaction_10572690", "reactome": "R-CEL-9648983", "name": "HTR3A pentamer:5HT transports Na+,K+,Ca2+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74126", "species_74112", "species_74113" ], "products": [ "species_29804", "species_83910", "species_74016" ], "modifiers": [ [ "species_10572687", "catalyst" ] ], "additional_components": [ "O76554", "WBGene00000955", "P54244", "WBGene00000951", "P54245", "WBGene00017580", "P54246", "WBGene00000044", "Q19351", "WBGene00017375", "Q22079", "WBGene00011354", "Q22080", "WBGene00011355", "Q22081", "WBGene00011356", "Q22083", "WBGene00011358", "Q22084", "WBGene00011360", "Q22085", "WBGene00011359", "Q6BEQ0", "WBGene00013338", "Q6F6K3", "WBGene00000056", "Q95Y94", "WBGene00020048", "Q9NAM5", "WBGene00013655", "V6CJ96", "WBGene00022247", "A0A3P6P985", "WBGene00000060", "B1Q281", "WBGene00000059", "G5ECT0", "WBGene00012857", "G5EG72", "WBGene00000057", "G5EG88", "WBGene00000062", "G5EGR1", "WBGene00000061", "H2KML8", "WBGene00013534", "O16426", "WBGene00020236", "O18228", "WBGene00013300", "O44452", "WBGene00015412", "O61519", "WBGene00017544", "O61520", "WBGene00017543", "species_380585" ] }, "reaction_10527788": { "compartment": "compartment_70101", "id": "reaction_10527788", "reactome": "R-CEL-629595", "name": "Activation of highly calcium permeable postsynaptic nicotinic acetylcholine receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74112" ], "products": [ "species_74016" ], "modifiers": [ [ "species_10527785", "catalyst" ] ], "additional_components": [ "A0A3P6P985", "WBGene00000060", "P48182", "WBGene00000042", "Q9N587", "WBGene00006797", "G5EDF1", "WBGene00000051", "Q93149", "WBGene00000043", "Q23022", "WBGene00006774", "O17274", "WBGene00020836", "Q93329", "WBGene00002975", "Q23355", "WBGene00000047", "P48181", "WBGene00006765", "Q9N4M3", "WBGene00000045", "Q27218", "WBGene00002974", "H2KZY7", "WBGene00022283", "B3WFZ2", "WBGene00000058", "species_372533" ] }, "reaction_10527790": { "compartment": "compartment_984", "id": "reaction_10527790", "reactome": "R-CEL-629596", "name": "Binding of acetylcholine to highly calcium permeable postsynaptic nicotinic acetylcholine receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10527783", "species_372533" ], "products": [ "species_10527785" ], "modifiers": [], "additional_components": [ "A0A3P6P985", "WBGene00000060", "P48182", "WBGene00000042", "Q9N587", "WBGene00006797", "G5EDF1", "WBGene00000051", "Q93149", "WBGene00000043", "Q23022", "WBGene00006774", "O17274", "WBGene00020836", "Q93329", "WBGene00002975", "Q23355", "WBGene00000047", "P48181", "WBGene00006765", "Q9N4M3", "WBGene00000045", "Q27218", "WBGene00002974", "H2KZY7", "WBGene00022283", "B3WFZ2", "WBGene00000058", "A0A3P6P985", "WBGene00000060", "P48182", "WBGene00000042", "Q9N587", "WBGene00006797", "G5EDF1", "WBGene00000051", "Q93149", "WBGene00000043", "Q23022", "WBGene00006774", "O17274", "WBGene00020836", "Q93329", "WBGene00002975", "Q23355", "WBGene00000047", "P48181", "WBGene00006765", "Q9N4M3", "WBGene00000045", "Q27218", "WBGene00002974", "H2KZY7", "WBGene00022283", "B3WFZ2", "WBGene00000058", "species_372533" ] }, "reaction_10527792": { "compartment": "compartment_984", "id": "reaction_10527792", "reactome": "R-CEL-629599", "name": "Binding of acetylcholine to highly calcium permeable acetylcholine receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_372533", "species_10527760" ], "products": [ "species_10527762" ], "modifiers": [], "additional_components": [ "O17274", "WBGene00020836", "Q9N4M3", "WBGene00000045", "P48181", "WBGene00006765", "Q9N587", "WBGene00006797", "P48182", "WBGene00000042", "Q23022", "WBGene00006774", "Q23355", "WBGene00000047", "Q27218", "WBGene00002974", "Q93149", "WBGene00000043", "G5EDF1", "WBGene00000051", "Q93329", "WBGene00002975", "H2KZY7", "WBGene00022283", "O17274", "WBGene00020836", "Q9N4M3", "WBGene00000045", "P48181", "WBGene00006765", "Q9N587", "WBGene00006797", "P48182", "WBGene00000042", "Q23022", "WBGene00006774", "Q23355", "WBGene00000047", "Q27218", "WBGene00002974", "Q93149", "WBGene00000043", "G5EDF1", "WBGene00000051", "Q93329", "WBGene00002975", "H2KZY7", "WBGene00022283", "species_372533" ] }, "reaction_10527765": { "compartment": "compartment_876", "id": "reaction_10527765", "reactome": "R-CEL-622326", "name": "Activation of highly calcium permeable nicotinic acetylcholine receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74112" ], "products": [ "species_74016" ], "modifiers": [ [ "species_10527762", "catalyst" ] ], "additional_components": [ "O17274", "WBGene00020836", "Q9N4M3", "WBGene00000045", "P48181", "WBGene00006765", "Q9N587", "WBGene00006797", "P48182", "WBGene00000042", "Q23022", "WBGene00006774", "Q23355", "WBGene00000047", "Q27218", "WBGene00002974", "Q93149", "WBGene00000043", "G5EDF1", "WBGene00000051", "Q93329", "WBGene00002975", "H2KZY7", "WBGene00022283", "species_372533" ] }, "reaction_10572694": { "compartment": "compartment_876", "id": "reaction_10572694", "reactome": "R-CEL-9649108", "name": "HTR3A pentamer binds 5HT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_114523", "species_10572692" ], "products": [ "species_10572687" ], "modifiers": [], "additional_components": [ "O76554", "WBGene00000955", "P54244", "WBGene00000951", "P54245", "WBGene00017580", "P54246", "WBGene00000044", "Q19351", "WBGene00017375", "Q22079", "WBGene00011354", "Q22080", "WBGene00011355", "Q22081", "WBGene00011356", "Q22083", "WBGene00011358", "Q22084", "WBGene00011360", "Q22085", "WBGene00011359", "Q6BEQ0", "WBGene00013338", "Q6F6K3", "WBGene00000056", "Q95Y94", "WBGene00020048", "Q9NAM5", "WBGene00013655", "V6CJ96", "WBGene00022247", "A0A3P6P985", "WBGene00000060", "B1Q281", "WBGene00000059", "G5ECT0", "WBGene00012857", "G5EG72", "WBGene00000057", "G5EG88", "WBGene00000062", "G5EGR1", "WBGene00000061", "H2KML8", "WBGene00013534", "O16426", "WBGene00020236", "O18228", "WBGene00013300", "O44452", "WBGene00015412", "O61519", "WBGene00017544", "O61520", "WBGene00017543", "O76554", "WBGene00000955", "P54244", "WBGene00000951", "P54245", "WBGene00017580", "P54246", "WBGene00000044", "Q19351", "WBGene00017375", "Q22079", "WBGene00011354", "Q22080", "WBGene00011355", "Q22081", "WBGene00011356", "Q22083", "WBGene00011358", "Q22084", "WBGene00011360", "Q22085", "WBGene00011359", "Q6BEQ0", "WBGene00013338", "Q6F6K3", "WBGene00000056", "Q95Y94", "WBGene00020048", "Q9NAM5", "WBGene00013655", "V6CJ96", "WBGene00022247", "A0A3P6P985", "WBGene00000060", "B1Q281", "WBGene00000059", "G5ECT0", "WBGene00012857", "G5EG72", "WBGene00000057", "G5EG88", "WBGene00000062", "G5EGR1", "WBGene00000061", "H2KML8", "WBGene00013534", "O16426", "WBGene00020236", "O18228", "WBGene00013300", "O44452", "WBGene00015412", "O61519", "WBGene00017544", "O61520", "WBGene00017543", "species_380585" ] }, "reaction_10571568": { "compartment": "compartment_7660", "id": "reaction_10571568", "reactome": "R-CEL-9029434", "name": "p-S363,S380,T573 RS6K translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10571566" ], "products": [ "species_10524491" ], "modifiers": [], "additional_components": [ "Q21734", "WBGene00011352", "Q19858", "WBGene00017898", "Q21734", "WBGene00011352", "Q19858", "WBGene00017898" ] }, "reaction_10524494": { "compartment": "compartment_7660", "id": "reaction_10524494", "reactome": "R-CEL-442724", "name": "Phosphorylation of CREB1 by ribosomal protein S6 kinases (RSKs)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10514243" ], "products": [ "species_113582", "species_10514246" ], "modifiers": [ [ "species_10524491", "catalyst" ] ], "additional_components": [ "WBGene00000793", "WBGene00000793", "Q21734", "WBGene00011352", "Q19858", "WBGene00017898" ] }, "reaction_10572227": { "compartment": "compartment_70101", "id": "reaction_10572227", "reactome": "R-CEL-9619355", "name": "CaMKK autophosphorylates in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10572220", "species_113592" ], "products": [ "species_29370", "species_10572224" ], "modifiers": [ [ "species_10572220", "catalyst" ] ], "additional_components": [ "species_74016", "Q11083", "WBGene00020378", "P04630", "WBGene00000285", "G5EF37", "WBGene00003934", "A0A2C9C3L3", "WBGene00020378", "Q18136", "WBGene00006861", "Q09665", "WBGene00006583", "O02159", "WBGene00020378", "G5EDZ8", "WBGene00000288", "Q94288", "WBGene00000287", "Q09980", "WBGene00017394", "O16305", "WBGene00000552", "G5EEG0", "WBGene00000286", "Q3Y416", "WBGene00000518", "species_74016", "Q11083", "WBGene00020378", "P04630", "WBGene00000285", "G5EF37", "WBGene00003934", "A0A2C9C3L3", "WBGene00020378", "Q18136", "WBGene00006861", "Q09665", "WBGene00006583", "O02159", "WBGene00020378", "G5EDZ8", "WBGene00000288", "Q94288", "WBGene00000287", "Q09980", "WBGene00017394", "O16305", "WBGene00000552", "G5EEG0", "WBGene00000286", "Q3Y416", "WBGene00000518", "species_74016", "Q11083", "WBGene00020378", "P04630", "WBGene00000285", "G5EF37", "WBGene00003934", "A0A2C9C3L3", "WBGene00020378", "Q18136", "WBGene00006861", "Q09665", "WBGene00006583", "O02159", "WBGene00020378", "G5EDZ8", "WBGene00000288", "Q94288", "WBGene00000287", "Q09980", "WBGene00017394", "O16305", "WBGene00000552", "G5EEG0", "WBGene00000286", "Q3Y416", "WBGene00000518" ] }, "reaction_10572236": { "compartment": "compartment_70101", "id": "reaction_10572236", "reactome": "R-CEL-9619376", "name": "CAMK1 binds calmodulin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10572232", "species_10508995" ], "products": [ "species_10572234" ], "modifiers": [], "additional_components": [ "WBGene00000553", "species_74016", "Q11083", "WBGene00020378", "P04630", "WBGene00000285", "G5EF37", "WBGene00003934", "A0A2C9C3L3", "WBGene00020378", "Q18136", "WBGene00006861", "Q09665", "WBGene00006583", "O02159", "WBGene00020378", "G5EDZ8", "WBGene00000288", "Q94288", "WBGene00000287", "Q09980", "WBGene00017394", "O16305", "WBGene00000552", "G5EEG0", "WBGene00000286", "species_74016", "Q11083", "WBGene00020378", "P04630", "WBGene00000285", "G5EF37", "WBGene00003934", "A0A2C9C3L3", "WBGene00020378", "Q18136", "WBGene00006861", "Q09665", "WBGene00006583", "O02159", "WBGene00020378", "G5EDZ8", "WBGene00000288", "Q94288", "WBGene00000287", "Q09980", "WBGene00017394", "O16305", "WBGene00000552", "G5EEG0", "WBGene00000286", "Q9TXJ0", "WBGene00000553" ] }, "reaction_10523910": { "compartment": "compartment_984", "id": "reaction_10523910", "reactome": "R-CEL-432164", "name": "Ca2+ influx into the post-synaptic cell", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74112" ], "products": [ "species_74016" ], "modifiers": [ [ "species_10523907", "catalyst" ], [ "species_9635195", "inhibitor" ] ], "additional_components": [ "G5ECY0", "WBGene00001006", "Q22638", "WBGene00011890", "G5EEH3", "WBGene00003775", "G5EGQ9", "WBGene00003774", "Q23158", "WBGene00000228", "O61967", "WBGene00002632", "O62305", "WBGene00006779", "species_376186", "species_159549", "species_113552" ] }, "reaction_10524270": { "compartment": "compartment_876", "id": "reaction_10524270", "reactome": "R-CEL-438037", "name": "Membrane depolarization upon activation of Ca impermeable AMPA receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74113" ], "products": [ "species_83910" ], "modifiers": [ [ "species_10521150", "catalyst" ], [ "species_10524268", "catalyst" ] ], "additional_components": [ "Q10914", "WBGene00001613", "Q21415", "WBGene00001614", "Q8MXV8", "WBGene00001617", "P34299", "WBGene00001612", "species_113552", "O61967", "WBGene00002632", "G5ECY0", "WBGene00001006", "Q22638", "WBGene00011890", "G5EGQ9", "WBGene00003774", "G5EEH3", "WBGene00003775", "Q23158", "WBGene00000228", "O62305", "WBGene00006779", "species_376186", "species_159549", "species_113552", "species_74016", "Q11083", "WBGene00020378", "P04630", "WBGene00000285", "G5EF37", "WBGene00003934", "A0A2C9C3L3", "WBGene00020378", "Q18136", "WBGene00006861", "Q09665", "WBGene00006583", "O02159", "WBGene00020378", "G5EDZ8", "WBGene00000288", "Q94288", "WBGene00000287", "Q09980", "WBGene00017394", "O16305", "WBGene00000552", "G5EEG0", "WBGene00000286" ] }, "reaction_10571984": { "compartment": "compartment_12045", "id": "reaction_10571984", "reactome": "R-CEL-9609742", "name": "Formation of di-heterotetramers of GluN1 (GRIN1) and GluN2A (GRIN2A)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10571980", "species_10571978" ], "products": [ "species_10571982" ], "modifiers": [], "additional_components": [ "WBGene00003775", "WBGene00003774", "G5EGQ9", "WBGene00003774", "G5EEH3", "WBGene00003775" ] }, "reaction_10572100": { "compartment": "compartment_12045", "id": "reaction_10572100", "reactome": "R-CEL-9610750", "name": "GluN1:GluN2 (GRIN1:GRIN2) NMDA receptors traffic to the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10572098" ], "products": [ "species_10523874" ], "modifiers": [], "additional_components": [ "G5EEH3", "WBGene00003775", "G5EGQ9", "WBGene00003774", "G5EEH3", "WBGene00003775", "G5EGQ9", "WBGene00003774" ] }, "reaction_10530193": { "compartment": "compartment_876", "id": "reaction_10530193", "reactome": "R-CEL-975340", "name": "GABR heteropentamers:GABA transport Cl- from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_188972" ], "products": [ "species_352022" ], "modifiers": [ [ "species_10530190", "catalyst" ] ], "additional_components": [ "species_352003", "Q6BET0", "WBGene00008551", "G5ECN1", "WBGene00013914", "A5JYS3", "WBGene00045385", "Q17999", "WBGene00007594", "G5ECD3", "WBGene00006784", "Q4W520", "WBGene00044301", "G5ECJ0", "WBGene00001373", "A0A3P6NNS2", "WBGene00017389", "Q9U2E2", "WBGene00012915", "O18276", "WBGene00001512" ] }, "reaction_10530517": { "compartment": "compartment_876", "id": "reaction_10530517", "reactome": "R-CEL-975449", "name": "GABRR pentamers:GABA transports extracellular Cl- to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_188972" ], "products": [ "species_352022" ], "modifiers": [ [ "species_10530514", "catalyst" ] ], "additional_components": [ "Q4W520", "WBGene00044301", "Q9U2E2", "WBGene00012915", "A0A3P6NNS2", "WBGene00017389", "A5JYS3", "WBGene00045385", "G5ECD3", "WBGene00006784", "G5ECJ0", "WBGene00001373", "O18276", "WBGene00001512", "Q17999", "WBGene00007594", "species_352003" ] }, "reaction_10531856": { "compartment": "compartment_876", "id": "reaction_10531856", "reactome": "R-CEL-1013013", "name": "Association of GABA B receptor with G protein beta-gamma subunits", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509165", "species_10519831" ], "products": [ "species_10531752" ], "modifiers": [ [ "species_10519831", "catalyst" ] ], "additional_components": [ "P17343", "WBGene00001679", "P54406", "WBGene00001681", "G5ECB2", "WBGene00022675", "H2L0Q3", "WBGene00021528", "species_352003", "G5ECB2", "WBGene00022675", "H2L0Q3", "WBGene00021528", "species_352003", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "G5ECB2", "WBGene00022675", "H2L0Q3", "WBGene00021528", "species_352003" ] }, "reaction_10531859": { "compartment": "compartment_70101", "id": "reaction_10531859", "reactome": "R-CEL-1013020", "name": "Activation of GIRK/Kir3 Channels", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10531851", "catalyst" ] ], "additional_components": [ "G5ECB2", "WBGene00022675", "H2L0Q3", "WBGene00021528", "species_352003", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "A0A1C3NSK2", "WBGene00002151", "A0A1C3NSN6", "WBGene00002150", "P52192", "WBGene00002149" ] }, "reaction_10531854": { "compartment": "compartment_876", "id": "reaction_10531854", "reactome": "R-CEL-1013012", "name": "Binding of Gbeta/gamma to GIRK/Kir3 channels", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10531849", "species_10531752" ], "products": [ "species_10531851" ], "modifiers": [ [ "species_10519831", "catalyst" ] ], "additional_components": [ "A0A1C3NSK2", "WBGene00002151", "A0A1C3NSN6", "WBGene00002150", "P52192", "WBGene00002149", "G5ECB2", "WBGene00022675", "H2L0Q3", "WBGene00021528", "species_352003", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "G5ECB2", "WBGene00022675", "H2L0Q3", "WBGene00021528", "species_352003", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "A0A1C3NSK2", "WBGene00002151", "A0A1C3NSN6", "WBGene00002150", "P52192", "WBGene00002149", "G5ECB2", "WBGene00022675", "H2L0Q3", "WBGene00021528", "species_352003" ] }, "reaction_10522049": { "compartment": "compartment_984", "id": "reaction_10522049", "reactome": "R-CEL-420977", "name": "Ca permeable AMPA receptor ligand binding", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_210382", "species_10521159" ], "products": [ "species_10521161" ], "modifiers": [], "additional_components": [ "Q10914", "WBGene00001613", "Q21415", "WBGene00001614", "Q8MXV8", "WBGene00001617", "P34299", "WBGene00001612", "Q10914", "WBGene00001613", "Q21415", "WBGene00001614", "Q8MXV8", "WBGene00001617", "P34299", "WBGene00001612", "species_113552" ] }, "reaction_10521153": { "compartment": "compartment_876", "id": "reaction_10521153", "reactome": "R-CEL-399711", "name": "Activation of Ca impermeable AMPA receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74113" ], "products": [ "species_83910" ], "modifiers": [ [ "species_10521150", "catalyst" ] ], "additional_components": [ "Q10914", "WBGene00001613", "Q21415", "WBGene00001614", "Q8MXV8", "WBGene00001617", "P34299", "WBGene00001612", "species_113552" ] }, "reaction_10522051": { "compartment": "compartment_876", "id": "reaction_10522051", "reactome": "R-CEL-420980", "name": "Activation of Ca permeable AMPA receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74113" ], "products": [ "species_83910" ], "modifiers": [ [ "species_10521161", "catalyst" ] ], "additional_components": [ "Q10914", "WBGene00001613", "Q21415", "WBGene00001614", "Q8MXV8", "WBGene00001617", "P34299", "WBGene00001612", "species_113552" ] }, "reaction_10522047": { "compartment": "compartment_984", "id": "reaction_10522047", "reactome": "R-CEL-420975", "name": "Ca impermeable AMPA receptor ligand binding", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_210382", "species_10521148" ], "products": [ "species_10521150" ], "modifiers": [], "additional_components": [ "Q10914", "WBGene00001613", "Q21415", "WBGene00001614", "Q8MXV8", "WBGene00001617", "P34299", "WBGene00001612", "Q10914", "WBGene00001613", "Q21415", "WBGene00001614", "Q8MXV8", "WBGene00001617", "P34299", "WBGene00001612", "species_113552" ] }, "reaction_10530046": { "compartment": "compartment_876", "id": "reaction_10530046", "reactome": "R-CEL-975311", "name": "HTR3 pentamers:5HT transport Na+,K+,Ca2+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74126", "species_74112", "species_74113" ], "products": [ "species_29804", "species_83910", "species_74016" ], "modifiers": [ [ "species_10530043", "catalyst" ] ], "additional_components": [ "O76554", "WBGene00000955", "P54244", "WBGene00000951", "P54245", "WBGene00017580", "P54246", "WBGene00000044", "Q19351", "WBGene00017375", "Q22079", "WBGene00011354", "Q22080", "WBGene00011355", "Q22081", "WBGene00011356", "Q22083", "WBGene00011358", "Q22084", "WBGene00011360", "Q22085", "WBGene00011359", "Q6BEQ0", "WBGene00013338", "Q6F6K3", "WBGene00000056", "Q95Y94", "WBGene00020048", "Q9NAM5", "WBGene00013655", "V6CJ96", "WBGene00022247", "A0A3P6P985", "WBGene00000060", "B1Q281", "WBGene00000059", "G5ECT0", "WBGene00012857", "G5EG72", "WBGene00000057", "G5EG88", "WBGene00000062", "G5EGR1", "WBGene00000061", "H2KML8", "WBGene00013534", "O16426", "WBGene00020236", "O18228", "WBGene00013300", "O44452", "WBGene00015412", "O61519", "WBGene00017544", "O61520", "WBGene00017543", "species_380585" ] }, "reaction_10518753": { "compartment": "compartment_876", "id": "reaction_10518753", "reactome": "R-CEL-374680", "name": "L1 trans-homophilic interaction", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10518718", "species_10518749" ], "products": [ "species_10518751" ], "modifiers": [], "additional_components": [ "Q21465", "WBGene00019727", "Q5WRR1", "WBGene00006942", "G5EBK3", "WBGene00001333", "species_179856", "Q21465", "WBGene00019727", "Q5WRR1", "WBGene00006942", "G5EBK3", "WBGene00001333", "species_179856", "Q21465", "WBGene00019727", "Q5WRR1", "WBGene00006942" ] }, "reaction_10524545": { "compartment": "compartment_70101", "id": "reaction_10524545", "reactome": "R-CEL-443779", "name": "Linkage of L1 with treadmilling F-actin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10518751", "species_10523755" ], "products": [ "species_10524543" ], "modifiers": [], "additional_components": [ "G5EBK3", "WBGene00001333", "species_179856", "Q21465", "WBGene00019727", "Q5WRR1", "WBGene00006942", "P0DM41", "WBGene00000063", "P0DM42", "WBGene00000065", "P10984", "WBGene00000064", "P10986", "WBGene00000066", "species_29358", "P0DM41", "WBGene00000063", "P0DM42", "WBGene00000065", "P10984", "WBGene00000064", "P10986", "WBGene00000066", "species_29358", "G5EBK3", "WBGene00001333", "species_179856", "Q21465", "WBGene00019727", "Q5WRR1", "WBGene00006942" ] }, "reaction_10521063": { "compartment": "compartment_876", "id": "reaction_10521063", "reactome": "R-CEL-392748", "name": "L1 binds to AP-2 Clathrin complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10518718", "species_10512100" ], "products": [ "species_10521061" ], "modifiers": [], "additional_components": [ "Q21465", "WBGene00019727", "Q5WRR1", "WBGene00006942", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q21465", "WBGene00019727", "Q5WRR1", "WBGene00006942" ] }, "reaction_10527463": { "compartment": "compartment_876", "id": "reaction_10527463", "reactome": "R-CEL-555065", "name": "Formation of clathrin coated vesicle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10512105", "species_10521061" ], "products": [ "species_29372", "species_29420", "species_10521065" ], "modifiers": [ [ "species_10512940", "catalyst" ] ], "additional_components": [ "WBGene00006791", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q21465", "WBGene00019727", "Q5WRR1", "WBGene00006942", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "B1V8A0", "WBGene00006791", "Q21465", "WBGene00019727", "Q5WRR1", "WBGene00006942" ] }, "reaction_10524730": { "compartment": "compartment_70101", "id": "reaction_10524730", "reactome": "R-CEL-445079", "name": "Phosphorylation of L1 by ERK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10521065", "species_113592", "species_10508599" ], "products": [ "species_29370", "species_10524727" ], "modifiers": [ [ "species_10508599", "catalyst" ] ], "additional_components": [ "P34574", "WBGene00011867", "P90961", "WBGene00020246", "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "B1V8A0", "WBGene00006791", "Q21465", "WBGene00019727", "Q5WRR1", "WBGene00006942", "WBGene00003401", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q5WRR1", "WBGene00006942", "Q21465", "WBGene00019727", "P39745", "WBGene00003401", "B1V8A0", "WBGene00006791", "WBGene00003401" ] }, "reaction_10521067": { "compartment": "compartment_17940", "id": "reaction_10521067", "reactome": "R-CEL-392749", "name": "Transport of L1 into endosomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10521065" ], "products": [ "species_10521065" ], "modifiers": [], "additional_components": [ "P34574", "WBGene00011867", "P90961", "WBGene00020246", "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "B1V8A0", "WBGene00006791", "Q21465", "WBGene00019727", "Q5WRR1", "WBGene00006942", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "B1V8A0", "WBGene00006791", "Q21465", "WBGene00019727", "Q5WRR1", "WBGene00006942" ] }, "reaction_10524732": { "compartment": "compartment_70101", "id": "reaction_10524732", "reactome": "R-CEL-445084", "name": "Phosphorylation of L1 by SRC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10518718", "species_113592" ], "products": [ "species_10518747", "species_29370" ], "modifiers": [ [ "species_10513079", "catalyst" ] ], "additional_components": [ "Q21465", "WBGene00019727", "Q5WRR1", "WBGene00006942", "Q21465", "WBGene00019727", "Q5WRR1", "WBGene00006942", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635" ] }, "reaction_10524556": { "compartment": "compartment_876", "id": "reaction_10524556", "reactome": "R-CEL-443783", "name": "Interaction of NUMB with L1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10518718", "species_10524552" ], "products": [ "species_10524554" ], "modifiers": [], "additional_components": [ "Q21465", "WBGene00019727", "Q5WRR1", "WBGene00006942", "Q22601", "WBGene00000161", "Q9XTY6", "WBGene00003830", "Q18677", "WBGene00000964", "Q21773", "WBGene00000963", "Q01630", "WBGene00006769", "Q22601", "WBGene00000161", "Q9XTY6", "WBGene00003830", "Q18677", "WBGene00000964", "Q21773", "WBGene00000963", "Q01630", "WBGene00006769", "Q21465", "WBGene00019727", "Q5WRR1", "WBGene00006942" ] }, "reaction_10566112": { "compartment": "compartment_7660", "id": "reaction_10566112", "reactome": "R-CEL-8864278", "name": "AP-2 (TFAP2) transcription factors form homo- and heterodimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10566108" ], "products": [ "species_10566110" ], "modifiers": [], "additional_components": [ "Q09585", "WBGene00019424", "Q19862", "WBGene00009203", "Q19863", "WBGene00009202", "G2HK15", "WBGene00013383", "Q09585", "WBGene00019424", "Q19862", "WBGene00009203", "Q19863", "WBGene00009202", "G2HK15", "WBGene00013383" ] }, "reaction_10566136": { "compartment": "compartment_7660", "id": "reaction_10566136", "reactome": "R-CEL-8864595", "name": "TFAP2B homodimer binds YEATS4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10566132", "species_10566130" ], "products": [ "species_10566134" ], "modifiers": [], "additional_components": [ "Q09585", "WBGene00019424", "Q19862", "WBGene00009203", "Q19863", "WBGene00009202", "G2HK15", "WBGene00013383", "WBGene00001585", "Q21501", "WBGene00001585", "Q09585", "WBGene00019424", "Q19862", "WBGene00009203", "Q19863", "WBGene00009202", "G2HK15", "WBGene00013383" ] }, "reaction_10566124": { "compartment": "compartment_70101", "id": "reaction_10566124", "reactome": "R-CEL-8864577", "name": "TFAP2C translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10566118" ], "products": [ "species_10546739" ], "modifiers": [ [ "species_10566120", "inhibitor" ] ], "additional_components": [ "WBGene00019424", "WBGene00019424", "Q09585", "WBGene00019424", "Q19062", "WBGene00000971" ] }, "reaction_10546753": { "compartment": "compartment_7660", "id": "reaction_10546753", "reactome": "R-CEL-3234094", "name": "SUMOylation of TFAP2C with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546741", "species_10546081" ], "products": [ "species_10546751", "species_10546073" ], "modifiers": [ [ "species_10546081", "catalyst" ] ], "additional_components": [ "Q09585", "WBGene00019424", "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "Q09585", "WBGene00019424", "P55853", "WBGene00004888", "WBGene00006706", "Q95017", "WBGene00006706", "P55853", "WBGene00004888" ] }, "reaction_10566122": { "compartment": "compartment_70101", "id": "reaction_10566122", "reactome": "R-CEL-8864569", "name": "WWOX binds TFAP2C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10532620", "species_10566118" ], "products": [ "species_10566120" ], "modifiers": [], "additional_components": [ "WBGene00000971", "WBGene00019424", "Q09585", "WBGene00019424", "Q19062", "WBGene00000971" ] }, "reaction_10529266": { "compartment": "compartment_70101", "id": "reaction_10529266", "reactome": "R-CEL-927789", "name": "Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10529262", "species_10529242" ], "products": [ "species_10529264" ], "modifiers": [], "additional_components": [ "P91914", "WBGene00004441", "Q19869", "WBGene00004440", "O01868", "WBGene00004436", "P48162", "WBGene00004438", "P52819", "WBGene00004434", "P48158", "WBGene00004435", "Q09533", "WBGene00004421", "P34334", "WBGene00004433", "O02639", "WBGene00004431", "Q95Y90", "WBGene00004420", "O44480", "WBGene00004432", "Q22716", "WBGene00004446", "Q9U332", "WBGene00004445", "Q9XWS4", "WBGene00004444", "P52814", "WBGene00004453", "O45226", "WBGene00004443", "Q21930", "WBGene00004442", "P48166", "WBGene00004454", "Q9BKU5", "WBGene00021350", "P50880", "WBGene00004414", "P61866", "WBGene00004424", "O17570", "WBGene00004452", "Q19162", "WBGene00004423", "Q9U2A8", "WBGene00004456", "Q9N4I4", "WBGene00004412", "O62388", "WBGene00012179", "O01504", "WBGene00016493", "P49181", "WBGene00004450", "P91913", "WBGene00004409", "P49180", "WBGene00004447", "Q93572", "WBGene00004408", "P34662", "WBGene00004449", "Q9XVF7", "WBGene00004413", "O45946", "WBGene00004430", "Q966C6", "WBGene00004419", "Q9BL19", "WBGene00004429", "O01802", "WBGene00004418", "P91374", "WBGene00004427", "P47991", "WBGene00004417", "Q9XVE9", "WBGene00004426", "P49405", "WBGene00004416", "Q27389", "WBGene00004428", "P37165", "WBGene00006725", "P91128", "WBGene00004425", "O02056", "WBGene00004415", "P51403", "WBGene00004471", "Q9NEN6", "WBGene00004475", "Q8WQA8", "WBGene00004489", "Q23312", "WBGene00004476", "O01869", "WBGene00004479", "P49197", "WBGene00004490", "P48156", "WBGene00004477", "Q20206", "WBGene00004480", "Q19877", "WBGene00004492", "Q20228", "WBGene00004478", "P49196", "WBGene00004481", "Q1XFY9", "WBGene00004493", "P46769", "WBGene00004469", "P51404", "WBGene00004482", "P52821", "WBGene00004494", "Q9TXP0", "WBGene00004496", "P48150", "WBGene00004483", "O45499", "WBGene00004495", "Q9N3X2", "WBGene00004473", "Q9XVP0", "WBGene00004484", "Q95Y04", "WBGene00004497", "Q22054", "WBGene00004485", "P90983", "WBGene00004498", "O01692", "WBGene00004486", "P48152", "WBGene00004472", "O18240", "WBGene00004487", "O18650", "WBGene00004488", "P48154", "WBGene00004470", "O17218", "WBGene00004491", "P49041", "WBGene00004474", "O45622", "WBGene00010405", "species_29420", "A0A486WX07", "WBGene00002066", "Q9U302", "WBGene00003902", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "O16520", "WBGene00020269", "WBGene00004880", "O76512", "WBGene00004880", "P91914", "WBGene00004441", "Q19869", "WBGene00004440", "O01868", "WBGene00004436", "P48162", "WBGene00004438", "P52819", "WBGene00004434", "P48158", "WBGene00004435", "Q09533", "WBGene00004421", "P34334", "WBGene00004433", "O02639", "WBGene00004431", "Q95Y90", "WBGene00004420", "O44480", "WBGene00004432", "Q22716", "WBGene00004446", "Q9U332", "WBGene00004445", "Q9XWS4", "WBGene00004444", "P52814", "WBGene00004453", "O45226", "WBGene00004443", "Q21930", "WBGene00004442", "P48166", "WBGene00004454", "Q9BKU5", "WBGene00021350", "P50880", "WBGene00004414", "P61866", "WBGene00004424", "O17570", "WBGene00004452", "Q19162", "WBGene00004423", "Q9U2A8", "WBGene00004456", "Q9N4I4", "WBGene00004412", "O62388", "WBGene00012179", "O01504", "WBGene00016493", "P49181", "WBGene00004450", "P91913", "WBGene00004409", "P49180", "WBGene00004447", "Q93572", "WBGene00004408", "P34662", "WBGene00004449", "Q9XVF7", "WBGene00004413", "O45946", "WBGene00004430", "Q966C6", "WBGene00004419", "Q9BL19", "WBGene00004429", "O01802", "WBGene00004418", "P91374", "WBGene00004427", "P47991", "WBGene00004417", "Q9XVE9", "WBGene00004426", "P49405", "WBGene00004416", "Q27389", "WBGene00004428", "P37165", "WBGene00006725", "P91128", "WBGene00004425", "O02056", "WBGene00004415", "P51403", "WBGene00004471", "Q9NEN6", "WBGene00004475", "Q8WQA8", "WBGene00004489", "Q23312", "WBGene00004476", "O01869", "WBGene00004479", "P49197", "WBGene00004490", "P48156", "WBGene00004477", "Q20206", "WBGene00004480", "Q19877", "WBGene00004492", "Q20228", "WBGene00004478", "P49196", "WBGene00004481", "Q1XFY9", "WBGene00004493", "P46769", "WBGene00004469", "P51404", "WBGene00004482", "P52821", "WBGene00004494", "Q9TXP0", "WBGene00004496", "P48150", "WBGene00004483", "O45499", "WBGene00004495", "Q9N3X2", "WBGene00004473", "Q9XVP0", "WBGene00004484", "Q95Y04", "WBGene00004497", "Q22054", "WBGene00004485", "P90983", "WBGene00004498", "O01692", "WBGene00004486", "P48152", "WBGene00004472", "O18240", "WBGene00004487", "O18650", "WBGene00004488", "P48154", "WBGene00004470", "O17218", "WBGene00004491", "P49041", "WBGene00004474", "O45622", "WBGene00010405", "species_29420", "A0A486WX07", "WBGene00002066", "Q9U302", "WBGene00003902", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "O16520", "WBGene00020269" ] }, "reaction_10508129": { "compartment": "compartment_7660", "id": "reaction_10508129", "reactome": "R-CEL-77068", "name": "Activation of GT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508127" ], "products": [ "species_10508127" ], "modifiers": [], "additional_components": [ "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q17607", "WBGene00000466", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q17607", "WBGene00000466" ] }, "reaction_10508162": { "compartment": "compartment_7660", "id": "reaction_10508162", "reactome": "R-CEL-77078", "name": "Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508155" ], "products": [ "species_113550", "species_10508159" ], "modifiers": [ [ "species_10508155", "catalyst" ] ], "additional_components": [ "Q21338", "WBGene00005015", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q17607", "WBGene00000466", "Q9XVS1", "WBGene00006447", "Q21338", "WBGene00005015", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q17607", "WBGene00000466", "Q9XVS1", "WBGene00006447", "Q21338", "WBGene00005015", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q17607", "WBGene00000466", "Q9XVS1", "WBGene00006447" ] }, "reaction_10508178": { "compartment": "compartment_7660", "id": "reaction_10508178", "reactome": "R-CEL-77085", "name": "Dissociation of transcript with 5'-GMP from GT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508171" ], "products": [ "species_10508176" ], "modifiers": [], "additional_components": [ "Q21338", "WBGene00005015", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q17607", "WBGene00000466", "Q9XVS1", "WBGene00006447", "Q21338", "WBGene00005015", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q17607", "WBGene00000466", "Q9XVS1", "WBGene00006447" ] }, "reaction_10508133": { "compartment": "compartment_7660", "id": "reaction_10508133", "reactome": "R-CEL-77069", "name": "RNA Polymerase II CTD (phosphorylated) binds to CE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508125", "species_10508131" ], "products": [ "species_10508127" ], "modifiers": [], "additional_components": [ "WBGene00000466", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q17607", "WBGene00000466" ] }, "reaction_10508183": { "compartment": "compartment_7660", "id": "reaction_10508183", "reactome": "R-CEL-77090", "name": "Methylation of GMP-cap by RNA Methyltransferase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10508176" ], "products": [ "species_77502", "species_10506316", "species_10504425", "species_10508149", "species_10508180" ], "modifiers": [ [ "species_10508176", "catalyst" ] ], "additional_components": [ "Q21338", "WBGene00005015", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q17607", "WBGene00000466", "Q9XVS1", "WBGene00006447", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "WBGene00005015", "Q17607", "WBGene00000466", "Q9XVS1", "WBGene00006447", "Q21338", "WBGene00005015", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q17607", "WBGene00000466", "Q9XVS1", "WBGene00006447" ] }, "reaction_10508169": { "compartment": "compartment_7660", "id": "reaction_10508169", "reactome": "R-CEL-77081", "name": "Formation of the CE:GMP intermediate complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508159", "species_113571" ], "products": [ "species_10508166", "species_111349" ], "modifiers": [ [ "species_10508159", "catalyst" ] ], "additional_components": [ "Q21338", "WBGene00005015", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q17607", "WBGene00000466", "Q9XVS1", "WBGene00006447", "Q21338", "WBGene00005015", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q17607", "WBGene00000466", "Q9XVS1", "WBGene00006447", "species_113578", "Q21338", "WBGene00005015", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q17607", "WBGene00000466", "Q9XVS1", "WBGene00006447" ] }, "reaction_10508185": { "compartment": "compartment_7660", "id": "reaction_10508185", "reactome": "R-CEL-77094", "name": "Formation of cap binding complex (CBC)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10504344", "species_10504339" ], "products": [ "species_10504346" ], "modifiers": [], "additional_components": [ "WBGene00018156", "WBGene00009141", "Q93594", "WBGene00009141", "O01763", "WBGene00018156" ] }, "reaction_10508153": { "compartment": "compartment_7660", "id": "reaction_10508153", "reactome": "R-CEL-77073", "name": "SPT5 subunit of Pol II binds the RNA triphosphatase (RTP)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508143", "species_10508127", "species_10508149" ], "products": [ "species_10508151" ], "modifiers": [], "additional_components": [ "WBGene00006447", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q17607", "WBGene00000466", "WBGene00005015", "Q21338", "WBGene00005015", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q17607", "WBGene00000466", "Q9XVS1", "WBGene00006447" ] }, "reaction_10508187": { "compartment": "compartment_7660", "id": "reaction_10508187", "reactome": "R-CEL-77095", "name": "Recognition and binding of the mRNA cap by the cap-binding complex ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10504346", "species_10504425" ], "products": [ "species_10504427" ], "modifiers": [], "additional_components": [ "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q93594", "WBGene00009141", "O01763", "WBGene00018156" ] }, "reaction_10508157": { "compartment": "compartment_7660", "id": "reaction_10508157", "reactome": "R-CEL-77077", "name": "Capping complex formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508151", "species_72084", "species_29428" ], "products": [ "species_10508155" ], "modifiers": [], "additional_components": [ "Q21338", "WBGene00005015", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q17607", "WBGene00000466", "Q9XVS1", "WBGene00006447", "Q21338", "WBGene00005015", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q17607", "WBGene00000466", "Q9XVS1", "WBGene00006447" ] }, "reaction_10508174": { "compartment": "compartment_7660", "id": "reaction_10508174", "reactome": "R-CEL-77083", "name": "Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508166" ], "products": [ "species_10508171" ], "modifiers": [ [ "species_10508166", "catalyst" ] ], "additional_components": [ "Q21338", "WBGene00005015", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q17607", "WBGene00000466", "Q9XVS1", "WBGene00006447", "species_113578", "Q21338", "WBGene00005015", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q17607", "WBGene00000466", "Q9XVS1", "WBGene00006447", "Q21338", "WBGene00005015", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q17607", "WBGene00000466", "Q9XVS1", "WBGene00006447", "species_113578" ] }, "reaction_10508321": { "compartment": "compartment_7660", "id": "reaction_10508321", "reactome": "R-CEL-77586", "name": "Cleavage of the 3'-end of Replication Dependent Histone Pre-mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508315" ], "products": [ "species_10508319", "species_10508313" ], "modifiers": [], "additional_components": [ "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "Q09599", "WBGene00000411", "Q20709", "WBGene00018740", "V6CKC3", "WBGene00021689", "Q9N4G9", "WBGene00004920", "Q7YWY5", "WBGene00010619", "Q9GYQ8", "WBGene00016791", "Q9XTU6", "WBGene00004919", "P91918", "WBGene00004915", "Q17348", "WBGene00004914", "P34659", "WBGene00004918", "Q93594", "WBGene00009141", "Q09599", "WBGene00000411", "O01763", "WBGene00018156", "Q20709", "WBGene00018740", "V6CKC3", "WBGene00021689", "Q9N4G9", "WBGene00004920", "Q7YWY5", "WBGene00010619", "Q9GYQ8", "WBGene00016791", "Q9XTU6", "WBGene00004919", "P91918", "WBGene00004915", "Q17348", "WBGene00004914", "P34659", "WBGene00004918" ] }, "reaction_10508283": { "compartment": "compartment_7660", "id": "reaction_10508283", "reactome": "R-CEL-77584", "name": "Binding of SLBP to Replication-Dependent Histone Pre-mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508279", "species_10508274" ], "products": [ "species_10508281" ], "modifiers": [], "additional_components": [ "WBGene00000411", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "Q09599", "WBGene00000411" ] }, "reaction_10508317": { "compartment": "compartment_7660", "id": "reaction_10508317", "reactome": "R-CEL-77585", "name": "Recruitment of U7 snRNP:ZFP100 complex to the SLBP Bound Pre-mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508313", "species_10508281" ], "products": [ "species_10508315" ], "modifiers": [], "additional_components": [ "Q20709", "WBGene00018740", "V6CKC3", "WBGene00021689", "Q9N4G9", "WBGene00004920", "Q7YWY5", "WBGene00010619", "Q9GYQ8", "WBGene00016791", "Q9XTU6", "WBGene00004919", "P91918", "WBGene00004915", "Q17348", "WBGene00004914", "P34659", "WBGene00004918", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "Q09599", "WBGene00000411", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "Q09599", "WBGene00000411", "Q20709", "WBGene00018740", "V6CKC3", "WBGene00021689", "Q9N4G9", "WBGene00004920", "Q7YWY5", "WBGene00010619", "Q9GYQ8", "WBGene00016791", "Q9XTU6", "WBGene00004919", "P91918", "WBGene00004915", "Q17348", "WBGene00004914", "P34659", "WBGene00004918" ] }, "reaction_10508337": { "compartment": "compartment_7660", "id": "reaction_10508337", "reactome": "R-CEL-77591", "name": "Binding of Cleavage factors and Poly(A)Polymerase to the CstF:CPSF:Pre-mRNA Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10505197", "species_10505213", "species_10508331", "species_10505225", "species_10505192" ], "products": [ "species_10508335" ], "modifiers": [], "additional_components": [ "WBGene00003904", "Q93716", "WBGene00009668", "C1P629", "WBGene00008362", "O45577", "WBGene00000774", "Q19864", "WBGene00000773", "Q19866", "WBGene00006307", "Q95PY8", "WBGene00013460", "U4PCM1", "WBGene00011051", "Q9N4C2", "WBGene00022301", "Q7YTG9", "WBGene00044329", "O17403", "WBGene00017313", "O16929", "WBGene00017797", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "P52874", "WBGene00010304", "Q09345", "WBGene00020092", "Q09995", "WBGene00011791", "Q9U2P3", "WBGene00012528", "G5EBX5", "WBGene00009658", "Q09995", "WBGene00011791", "Q9U2P3", "WBGene00012528", "G5EBX5", "WBGene00009658", "P52874", "WBGene00010304", "Q09345", "WBGene00020092", "O45577", "WBGene00000774", "Q19864", "WBGene00000773", "Q19866", "WBGene00006307", "Q95PY8", "WBGene00013460", "U4PCM1", "WBGene00011051", "Q9N4C2", "WBGene00022301", "Q7YTG9", "WBGene00044329", "O17403", "WBGene00017313", "O16929", "WBGene00017797", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "Q93716", "WBGene00009668", "C1P629", "WBGene00008362", "Q93233", "WBGene00003904" ] }, "reaction_10508341": { "compartment": "compartment_7660", "id": "reaction_10508341", "reactome": "R-CEL-77592", "name": "Cleavage of Intronless Pre-mRNA at 3'-end", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508335" ], "products": [ "species_10505213", "species_10505225", "species_10505175", "species_112165", "species_10508339" ], "modifiers": [], "additional_components": [ "Q09995", "WBGene00011791", "Q9U2P3", "WBGene00012528", "G5EBX5", "WBGene00009658", "P52874", "WBGene00010304", "Q09345", "WBGene00020092", "O45577", "WBGene00000774", "Q19864", "WBGene00000773", "Q19866", "WBGene00006307", "Q95PY8", "WBGene00013460", "U4PCM1", "WBGene00011051", "Q9N4C2", "WBGene00022301", "Q7YTG9", "WBGene00044329", "O17403", "WBGene00017313", "O16929", "WBGene00017797", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "Q93716", "WBGene00009668", "C1P629", "WBGene00008362", "Q93233", "WBGene00003904", "Q93716", "WBGene00009668", "C1P629", "WBGene00008362", "P52874", "WBGene00010304", "Q09345", "WBGene00020092", "O45577", "WBGene00000774", "Q19864", "WBGene00000773", "Q19866", "WBGene00006307", "Q93594", "WBGene00009141", "Q95PY8", "WBGene00013460", "U4PCM1", "WBGene00011051", "Q9N4C2", "WBGene00022301", "Q7YTG9", "WBGene00044329", "O17403", "WBGene00017313", "O16929", "WBGene00017797", "Q09995", "WBGene00011791", "Q9U2P3", "WBGene00012528", "G5EBX5", "WBGene00009658", "O01763", "WBGene00018156", "Q93233", "WBGene00003904" ] }, "reaction_10508329": { "compartment": "compartment_7660", "id": "reaction_10508329", "reactome": "R-CEL-77589", "name": "Recognition of AAUAAA sequence by CPSF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508325", "species_10505156" ], "products": [ "species_10508327" ], "modifiers": [], "additional_components": [ "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "Q95PY8", "WBGene00013460", "U4PCM1", "WBGene00011051", "Q9N4C2", "WBGene00022301", "Q7YTG9", "WBGene00044329", "O17403", "WBGene00017313", "O16929", "WBGene00017797", "Q95PY8", "WBGene00013460", "U4PCM1", "WBGene00011051", "Q9N4C2", "WBGene00022301", "Q7YTG9", "WBGene00044329", "O17403", "WBGene00017313", "O16929", "WBGene00017797", "Q93594", "WBGene00009141", "O01763", "WBGene00018156" ] }, "reaction_10508345": { "compartment": "compartment_7660", "id": "reaction_10508345", "reactome": "R-CEL-77593", "name": "Cleavage and polyadenylation of Intronless Pre-mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508335" ], "products": [ "species_10505213", "species_10505197", "species_10505225", "species_10505192", "species_10505175", "species_10508343" ], "modifiers": [], "additional_components": [ "Q09995", "WBGene00011791", "Q9U2P3", "WBGene00012528", "G5EBX5", "WBGene00009658", "P52874", "WBGene00010304", "Q09345", "WBGene00020092", "O45577", "WBGene00000774", "Q19864", "WBGene00000773", "Q19866", "WBGene00006307", "Q95PY8", "WBGene00013460", "U4PCM1", "WBGene00011051", "Q9N4C2", "WBGene00022301", "Q7YTG9", "WBGene00044329", "O17403", "WBGene00017313", "O16929", "WBGene00017797", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "Q93716", "WBGene00009668", "C1P629", "WBGene00008362", "Q93233", "WBGene00003904", "Q93716", "WBGene00009668", "C1P629", "WBGene00008362", "WBGene00003904", "P52874", "WBGene00010304", "Q09345", "WBGene00020092", "Q09995", "WBGene00011791", "Q9U2P3", "WBGene00012528", "G5EBX5", "WBGene00009658", "O45577", "WBGene00000774", "Q19864", "WBGene00000773", "Q19866", "WBGene00006307", "Q95PY8", "WBGene00013460", "U4PCM1", "WBGene00011051", "Q9N4C2", "WBGene00022301", "Q7YTG9", "WBGene00044329", "O17403", "WBGene00017313", "O16929", "WBGene00017797", "Q93594", "WBGene00009141", "O01763", "WBGene00018156" ] }, "reaction_10508333": { "compartment": "compartment_7660", "id": "reaction_10508333", "reactome": "R-CEL-77590", "name": "Recruitment of CstF to the CPSF Bound Pre-mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10505175", "species_10508327" ], "products": [ "species_10508331" ], "modifiers": [], "additional_components": [ "O45577", "WBGene00000774", "Q19864", "WBGene00000773", "Q19866", "WBGene00006307", "Q95PY8", "WBGene00013460", "U4PCM1", "WBGene00011051", "Q9N4C2", "WBGene00022301", "Q7YTG9", "WBGene00044329", "O17403", "WBGene00017313", "O16929", "WBGene00017797", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "O45577", "WBGene00000774", "Q19864", "WBGene00000773", "Q19866", "WBGene00006307", "Q95PY8", "WBGene00013460", "U4PCM1", "WBGene00011051", "Q9N4C2", "WBGene00022301", "Q7YTG9", "WBGene00044329", "O17403", "WBGene00017313", "O16929", "WBGene00017797", "Q93594", "WBGene00009141", "O01763", "WBGene00018156" ] }, "reaction_10508842": { "compartment": "compartment_7660", "id": "reaction_10508842", "reactome": "R-CEL-111437", "name": "Cleavage of the 3'-end of the Histone Pre-mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508838" ], "products": [ "species_10508313", "species_10508840" ], "modifiers": [], "additional_components": [ "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "Q20709", "WBGene00018740", "V6CKC3", "WBGene00021689", "Q9N4G9", "WBGene00004920", "Q7YWY5", "WBGene00010619", "Q9GYQ8", "WBGene00016791", "Q9XTU6", "WBGene00004919", "P91918", "WBGene00004915", "Q17348", "WBGene00004914", "P34659", "WBGene00004918", "Q20709", "WBGene00018740", "V6CKC3", "WBGene00021689", "Q9N4G9", "WBGene00004920", "Q7YWY5", "WBGene00010619", "Q9GYQ8", "WBGene00016791", "Q9XTU6", "WBGene00004919", "P91918", "WBGene00004915", "Q17348", "WBGene00004914", "P34659", "WBGene00004918", "Q93594", "WBGene00009141", "O01763", "WBGene00018156" ] }, "reaction_10508844": { "compartment": "compartment_7660", "id": "reaction_10508844", "reactome": "R-CEL-111438", "name": "Recruitment of U7 snRNP:ZFP100 complex to the Histone Pre-mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508313", "species_10508274" ], "products": [ "species_10508838" ], "modifiers": [], "additional_components": [ "Q20709", "WBGene00018740", "V6CKC3", "WBGene00021689", "Q9N4G9", "WBGene00004920", "Q7YWY5", "WBGene00010619", "Q9GYQ8", "WBGene00016791", "Q9XTU6", "WBGene00004919", "P91918", "WBGene00004915", "Q17348", "WBGene00004914", "P34659", "WBGene00004918", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "Q20709", "WBGene00018740", "V6CKC3", "WBGene00021689", "Q9N4G9", "WBGene00004920", "Q7YWY5", "WBGene00010619", "Q9GYQ8", "WBGene00016791", "Q9XTU6", "WBGene00004919", "P91918", "WBGene00004915", "Q17348", "WBGene00004914", "P34659", "WBGene00004918" ] }, "reaction_10527075": { "compartment": "compartment_70101", "id": "reaction_10527075", "reactome": "R-CEL-482788", "name": "p-S54,92,203-BRF1 binds 14-3-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10525899", "species_10507065" ], "products": [ "species_10527073" ], "modifiers": [], "additional_components": [ "G5EC86", "WBGene00003864", "Q09436", "WBGene00003231", "Q9XUB2", "WBGene00003230", "G5ECB9", "WBGene00003228", "Q20155", "WBGene00009532", "Q9XV46", "WBGene00003388", "G5EF15", "WBGene00004078", "Q23359", "WBGene00003865", "O02289", "WBGene00011376", "Q94131", "WBGene00004027", "O18251", "WBGene00013319", "Q9U1Y2", "WBGene00013797", "O45289", "WBGene00013797", "Q9U2V1", "WBGene00013797", "O45491", "WBGene00009537", "Q9U2V2", "WBGene00013797", "O45493", "WBGene00013797", "Q9U2V4", "WBGene00013794", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "G5EC86", "WBGene00003864", "Q09436", "WBGene00003231", "Q9XUB2", "WBGene00003230", "G5ECB9", "WBGene00003228", "Q20155", "WBGene00009532", "Q9XV46", "WBGene00003388", "G5EF15", "WBGene00004078", "Q23359", "WBGene00003865", "O02289", "WBGene00011376", "Q94131", "WBGene00004027", "O18251", "WBGene00013319", "Q9U1Y2", "WBGene00013797", "O45289", "WBGene00013797", "Q9U2V1", "WBGene00013797", "O45491", "WBGene00009537", "Q9U2V2", "WBGene00013797", "O45493", "WBGene00013797", "Q9U2V4", "WBGene00013794" ] }, "reaction_10525750": { "compartment": "compartment_70101", "id": "reaction_10525750", "reactome": "R-CEL-450406", "name": "p-S92,203-BRF1 binds 14-3-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10507065", "species_10525746" ], "products": [ "species_10525748" ], "modifiers": [], "additional_components": [ "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "O45491", "WBGene00009537", "Q9U2V2", "WBGene00013797", "O45493", "WBGene00013797", "Q9U2V4", "WBGene00013794", "G5EC86", "WBGene00003864", "Q09436", "WBGene00003231", "Q9XUB2", "WBGene00003230", "G5ECB9", "WBGene00003228", "Q20155", "WBGene00009532", "Q9XV46", "WBGene00003388", "G5EF15", "WBGene00004078", "Q23359", "WBGene00003865", "O02289", "WBGene00011376", "Q94131", "WBGene00004027", "O18251", "WBGene00013319", "Q9U1Y2", "WBGene00013797", "O45289", "WBGene00013797", "Q9U2V1", "WBGene00013797", "O45491", "WBGene00009537", "Q9U2V2", "WBGene00013797", "O45493", "WBGene00013797", "Q9U2V4", "WBGene00013794", "G5EC86", "WBGene00003864", "Q09436", "WBGene00003231", "Q9XUB2", "WBGene00003230", "G5ECB9", "WBGene00003228", "Q20155", "WBGene00009532", "Q9XV46", "WBGene00003388", "G5EF15", "WBGene00004078", "Q23359", "WBGene00003865", "O02289", "WBGene00011376", "Q94131", "WBGene00004027", "O18251", "WBGene00013319", "Q9U1Y2", "WBGene00013797", "O45289", "WBGene00013797", "Q9U2V1", "WBGene00013797", "P41932", "WBGene00003920", "Q20655", "WBGene00001502" ] }, "reaction_10525911": { "compartment": "compartment_70101", "id": "reaction_10525911", "reactome": "R-CEL-450488", "name": "BRF1 Complex recruits RNA degradation activities", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10525823", "species_10523562", "species_10523671", "species_10525907", "species_10523569" ], "products": [ "species_10525909" ], "modifiers": [], "additional_components": [ "O18251", "WBGene00013319", "O45289", "WBGene00013797", "O45491", "WBGene00009537", "O45493", "WBGene00013797", "Q09436", "WBGene00003231", "Q20155", "WBGene00009532", "Q23359", "WBGene00003865", "Q94131", "WBGene00004027", "Q9U1Y2", "WBGene00013797", "Q9U2V1", "WBGene00013797", "Q9U2V2", "WBGene00013797", "Q9U2V4", "WBGene00013794", "G5EC86", "WBGene00003864", "Q9XUB2", "WBGene00003230", "G5ECB9", "WBGene00003228", "Q9XV46", "WBGene00003388", "G5EF15", "WBGene00004078", "O02289", "WBGene00011376", "WBGene00021929", "Q95XD0", "WBGene00022232", "G5EDS8", "WBGene00009289", "Q95QG7", "WBGene00018305", "Q9N4P9", "WBGene00000202", "G5EG59", "WBGene00000798", "Q17533", "WBGene00007201", "Q20128", "WBGene00018154", "Q9XXD2", "WBGene00012966", "Q17632", "WBGene00001001", "Q93830", "WBGene00010325", "WBGene00012730", "WBGene00003582", "O62255", "WBGene00003582", "Q9BHK7", "WBGene00012730", "Q95XD0", "WBGene00022232", "G5EDS8", "WBGene00009289", "Q95QG7", "WBGene00018305", "Q9N4P9", "WBGene00000202", "G5EG59", "WBGene00000798", "Q17533", "WBGene00007201", "Q20128", "WBGene00018154", "Q9XXD2", "WBGene00012966", "Q17632", "WBGene00001001", "Q93830", "WBGene00010325", "Q9N363", "WBGene00021929", "O18251", "WBGene00013319", "O45289", "WBGene00013797", "O45491", "WBGene00009537", "O45493", "WBGene00013797", "Q09436", "WBGene00003231", "Q20155", "WBGene00009532", "Q23359", "WBGene00003865", "Q94131", "WBGene00004027", "Q9U1Y2", "WBGene00013797", "Q9U2V1", "WBGene00013797", "Q9U2V2", "WBGene00013797", "Q9U2V4", "WBGene00013794", "G5EC86", "WBGene00003864", "Q9XUB2", "WBGene00003230", "G5ECB9", "WBGene00003228", "Q9XV46", "WBGene00003388", "G5EF15", "WBGene00004078", "O02289", "WBGene00011376" ] }, "reaction_10525914": { "compartment": "compartment_70101", "id": "reaction_10525914", "reactome": "R-CEL-450490", "name": "Protein Kinase B/Akt phosphorylates BRF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10525823", "species_113592" ], "products": [ "species_29370", "species_10525746" ], "modifiers": [ [ "species_10513843", "catalyst" ] ], "additional_components": [ "O18251", "WBGene00013319", "O45289", "WBGene00013797", "O45491", "WBGene00009537", "O45493", "WBGene00013797", "Q09436", "WBGene00003231", "Q20155", "WBGene00009532", "Q23359", "WBGene00003865", "Q94131", "WBGene00004027", "Q9U1Y2", "WBGene00013797", "Q9U2V1", "WBGene00013797", "Q9U2V2", "WBGene00013797", "Q9U2V4", "WBGene00013794", "G5EC86", "WBGene00003864", "Q9XUB2", "WBGene00003230", "G5ECB9", "WBGene00003228", "Q9XV46", "WBGene00003388", "G5EF15", "WBGene00004078", "O02289", "WBGene00011376", "O45491", "WBGene00009537", "Q9U2V2", "WBGene00013797", "O45493", "WBGene00013797", "Q9U2V4", "WBGene00013794", "G5EC86", "WBGene00003864", "Q09436", "WBGene00003231", "Q9XUB2", "WBGene00003230", "G5ECB9", "WBGene00003228", "Q20155", "WBGene00009532", "Q9XV46", "WBGene00003388", "G5EF15", "WBGene00004078", "Q23359", "WBGene00003865", "O02289", "WBGene00011376", "Q94131", "WBGene00004027", "O18251", "WBGene00013319", "Q9U1Y2", "WBGene00013797", "O45289", "WBGene00013797", "Q9U2V1", "WBGene00013797", "Q9XTG7", "WBGene00000103", "G4S4W1", "WBGene00016980", "Q17941", "WBGene00000102" ] }, "reaction_10525932": { "compartment": "compartment_70101", "id": "reaction_10525932", "reactome": "R-CEL-450517", "name": "Butyrate Response Factor1 (BRF1) binds AU-rich element in 3' UTR of mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_450523", "species_10525821" ], "products": [ "species_10525823" ], "modifiers": [], "additional_components": [ "O18251", "WBGene00013319", "O45289", "WBGene00013797", "O45491", "WBGene00009537", "O45493", "WBGene00013797", "Q09436", "WBGene00003231", "Q20155", "WBGene00009532", "Q23359", "WBGene00003865", "Q94131", "WBGene00004027", "Q9U1Y2", "WBGene00013797", "Q9U2V1", "WBGene00013797", "Q9U2V2", "WBGene00013797", "Q9U2V4", "WBGene00013794", "G5EC86", "WBGene00003864", "Q9XUB2", "WBGene00003230", "G5ECB9", "WBGene00003228", "Q9XV46", "WBGene00003388", "G5EF15", "WBGene00004078", "O02289", "WBGene00011376", "O18251", "WBGene00013319", "O45289", "WBGene00013797", "O45491", "WBGene00009537", "O45493", "WBGene00013797", "Q09436", "WBGene00003231", "Q20155", "WBGene00009532", "Q23359", "WBGene00003865", "Q94131", "WBGene00004027", "Q9U1Y2", "WBGene00013797", "Q9U2V1", "WBGene00013797", "Q9U2V2", "WBGene00013797", "Q9U2V4", "WBGene00013794", "G5EC86", "WBGene00003864", "Q9XUB2", "WBGene00003230", "G5ECB9", "WBGene00003228", "Q9XV46", "WBGene00003388", "G5EF15", "WBGene00004078", "O02289", "WBGene00011376" ] }, "reaction_10525902": { "compartment": "compartment_70101", "id": "reaction_10525902", "reactome": "R-CEL-450474", "name": "MK2 phosphorylates BRF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10525823", "species_113592" ], "products": [ "species_10525899", "species_29370" ], "modifiers": [ [ "species_10512640", "catalyst" ] ], "additional_components": [ "O18251", "WBGene00013319", "O45289", "WBGene00013797", "O45491", "WBGene00009537", "O45493", "WBGene00013797", "Q09436", "WBGene00003231", "Q20155", "WBGene00009532", "Q23359", "WBGene00003865", "Q94131", "WBGene00004027", "Q9U1Y2", "WBGene00013797", "Q9U2V1", "WBGene00013797", "Q9U2V2", "WBGene00013797", "Q9U2V4", "WBGene00013794", "G5EC86", "WBGene00003864", "Q9XUB2", "WBGene00003230", "G5ECB9", "WBGene00003228", "Q9XV46", "WBGene00003388", "G5EF15", "WBGene00004078", "O02289", "WBGene00011376", "G5EC86", "WBGene00003864", "Q09436", "WBGene00003231", "Q9XUB2", "WBGene00003230", "G5ECB9", "WBGene00003228", "Q20155", "WBGene00009532", "Q9XV46", "WBGene00003388", "G5EF15", "WBGene00004078", "Q23359", "WBGene00003865", "O02289", "WBGene00011376", "Q94131", "WBGene00004027", "O18251", "WBGene00013319", "Q9U1Y2", "WBGene00013797", "O45289", "WBGene00013797", "Q9U2V1", "WBGene00013797", "O45491", "WBGene00009537", "Q9U2V2", "WBGene00013797", "O45493", "WBGene00013797", "Q9U2V4", "WBGene00013794", "Q21360", "WBGene00010681", "Q965G5", "WBGene00007007" ] }, "reaction_10525984": { "compartment": "compartment_70101", "id": "reaction_10525984", "reactome": "R-CEL-450620", "name": "p-S193-KSRP binds 14-3-3zeta in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10525928", "species_10525970" ], "products": [ "species_10525982" ], "modifiers": [], "additional_components": [ "Q17936", "WBGene00007534", "Q23487", "WBGene00022738", "Q9BLA0", "WBGene00016489", "P91393", "WBGene00019692", "Q20655", "WBGene00001502", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "P41932", "WBGene00003920", "P91393", "WBGene00019692", "Q17936", "WBGene00007534", "Q23487", "WBGene00022738", "Q9BLA0", "WBGene00016489" ] }, "reaction_10525783": { "compartment": "compartment_70101", "id": "reaction_10525783", "reactome": "R-CEL-450422", "name": "KSRP recruits RNA degradation activities", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10525774", "species_10523671", "species_10525779", "species_10523569" ], "products": [ "species_10525781" ], "modifiers": [], "additional_components": [ "Q17936", "WBGene00007534", "Q23487", "WBGene00022738", "Q9BLA0", "WBGene00016489", "P91393", "WBGene00019692", "Q95XD0", "WBGene00022232", "G5EDS8", "WBGene00009289", "Q95QG7", "WBGene00018305", "Q9N4P9", "WBGene00000202", "G5EG59", "WBGene00000798", "Q17533", "WBGene00007201", "Q20128", "WBGene00018154", "Q9XXD2", "WBGene00012966", "Q17632", "WBGene00001001", "Q93830", "WBGene00010325", "WBGene00010734", "WBGene00003582", "O62255", "WBGene00003582", "Q21412", "WBGene00010734", "Q95XD0", "WBGene00022232", "G5EDS8", "WBGene00009289", "Q95QG7", "WBGene00018305", "Q9N4P9", "WBGene00000202", "G5EG59", "WBGene00000798", "Q17533", "WBGene00007201", "Q20128", "WBGene00018154", "Q9XXD2", "WBGene00012966", "Q17632", "WBGene00001001", "Q93830", "WBGene00010325", "Q17936", "WBGene00007534", "Q23487", "WBGene00022738", "Q9BLA0", "WBGene00016489", "P91393", "WBGene00019692" ] }, "reaction_10525930": { "compartment": "compartment_70101", "id": "reaction_10525930", "reactome": "R-CEL-450499", "name": "Protein Kinase B (AKT) phosphorylates KSRP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10525772", "species_113592" ], "products": [ "species_29370", "species_10525928" ], "modifiers": [ [ "species_10513843", "catalyst" ] ], "additional_components": [ "Q17936", "WBGene00007534", "Q23487", "WBGene00022738", "Q9BLA0", "WBGene00016489", "P91393", "WBGene00019692", "Q17936", "WBGene00007534", "Q23487", "WBGene00022738", "Q9BLA0", "WBGene00016489", "P91393", "WBGene00019692", "Q9XTG7", "WBGene00000103", "G4S4W1", "WBGene00016980", "Q17941", "WBGene00000102" ] }, "reaction_10525964": { "compartment": "compartment_70101", "id": "reaction_10525964", "reactome": "R-CEL-450592", "name": "KSRP binds AU-rich element in 3' UTR of mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10525772", "species_450386" ], "products": [ "species_10525774" ], "modifiers": [], "additional_components": [ "Q17936", "WBGene00007534", "Q23487", "WBGene00022738", "Q9BLA0", "WBGene00016489", "P91393", "WBGene00019692", "Q17936", "WBGene00007534", "Q23487", "WBGene00022738", "Q9BLA0", "WBGene00016489", "P91393", "WBGene00019692" ] }, "reaction_10513160": { "compartment": "compartment_70101", "id": "reaction_10513160", "reactome": "R-CEL-191784", "name": "snRNA Cap hypermethylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10513152" ], "products": [ "species_10513139" ], "modifiers": [ [ "species_10513157", "catalyst" ] ], "additional_components": [ "G5ED26", "WBGene00020284", "G5EC16", "WBGene00004887", "P34399", "WBGene00017357", "O01871", "WBGene00017002", "Q9N405", "WBGene00004886", "A7LPI7", "WBGene00007702", "Q9XTU6", "WBGene00004919", "P34659", "WBGene00004918", "Q9N4G9", "WBGene00004920", "P91918", "WBGene00004915", "Q10013", "WBGene00004916", "Q18786", "WBGene00004917", "Q17348", "WBGene00004914", "CHEBI:2274", "CHEBI:1604", "G5ED26", "WBGene00020284", "G5EC16", "WBGene00004887", "P34399", "WBGene00017357", "O01871", "WBGene00017002", "Q9N405", "WBGene00004886", "A7LPI7", "WBGene00007702", "Q9XTU6", "WBGene00004919", "P34659", "WBGene00004918", "Q9N4G9", "WBGene00004920", "P91918", "WBGene00004915", "Q10013", "WBGene00004916", "Q18786", "WBGene00004917", "Q17348", "WBGene00004914", "WBGene00011631" ] }, "reaction_10513148": { "compartment": "compartment_70101", "id": "reaction_10513148", "reactome": "R-CEL-191763", "name": "snRNP:Snurportin complex formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10513144", "species_10513139" ], "products": [ "species_10513146" ], "modifiers": [], "additional_components": [ "WBGene00017746", "CHEBI:1604", "G5ED26", "WBGene00020284", "G5EC16", "WBGene00004887", "P34399", "WBGene00017357", "O01871", "WBGene00017002", "Q9N405", "WBGene00004886", "A7LPI7", "WBGene00007702", "Q9XTU6", "WBGene00004919", "P34659", "WBGene00004918", "Q9N4G9", "WBGene00004920", "P91918", "WBGene00004915", "Q10013", "WBGene00004916", "Q18786", "WBGene00004917", "Q17348", "WBGene00004914", "CHEBI:1604", "O17066", "WBGene00017746", "G5ED26", "WBGene00020284", "G5EC16", "WBGene00004887", "P34399", "WBGene00017357", "O01871", "WBGene00017002", "Q9N405", "WBGene00004886", "A7LPI7", "WBGene00007702", "Q9XTU6", "WBGene00004919", "P34659", "WBGene00004918", "Q9N4G9", "WBGene00004920", "P91918", "WBGene00004915", "Q10013", "WBGene00004916", "Q18786", "WBGene00004917", "Q17348", "WBGene00004914" ] }, "reaction_10523617": { "compartment": "compartment_70101", "id": "reaction_10523617", "reactome": "R-CEL-430021", "name": "PAN2-PAN3 complex partially deadenylates mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10523602" ], "products": [ "species_10523590", "species_76577" ], "modifiers": [ [ "species_10523614", "catalyst" ] ], "additional_components": [ "A0A486WX07", "WBGene00002066", "Q20935", "WBGene00018997", "P27639", "WBGene00002083", "Q9BL61", "WBGene00022029", "H2L0A8", "WBGene00019157", "O61955", "WBGene00002061", "Q9U302", "WBGene00003902", "A0A486WX07", "WBGene00002066", "Q20935", "WBGene00018997", "P27639", "WBGene00002083", "Q9BL61", "WBGene00022029", "H2L0A8", "WBGene00019157", "O61955", "WBGene00002061", "Q9U302", "WBGene00003902", "P53015", "WBGene00017951", "P34653", "WBGene00014015" ] }, "reaction_10568671": { "compartment": "compartment_70101", "id": "reaction_10568671", "reactome": "R-CEL-8941312", "name": "ZCCHC6, ZCCHC11 are mRNA uridyltransferases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6782337", "species_10523590" ], "products": [ "species_10568627" ], "modifiers": [ [ "species_10568668", "catalyst" ] ], "additional_components": [ "A0A486WX07", "WBGene00002066", "Q20935", "WBGene00018997", "P27639", "WBGene00002083", "Q9BL61", "WBGene00022029", "H2L0A8", "WBGene00019157", "O61955", "WBGene00002061", "Q9U302", "WBGene00003902", "species_6782337", "A0A486WX07", "WBGene00002066", "Q20935", "WBGene00018997", "P27639", "WBGene00002083", "Q9BL61", "WBGene00022029", "H2L0A8", "WBGene00019157", "O61955", "WBGene00002061", "Q9U302", "WBGene00003902", "Q09409", "WBGene00019629", "O02094", "WBGene00194706", "O44768", "WBGene00003499", "Q20377", "WBGene00194706", "G5EFR3", "WBGene00194706", "L8E6M1", "WBGene00194706", "Q09408", "WBGene00019628" ] }, "reaction_10523600": { "compartment": "compartment_70101", "id": "reaction_10523600", "reactome": "R-CEL-429978", "name": "Lsm1-7 Complex binds deadenylated mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10523548", "species_429974" ], "products": [ "species_10523550" ], "modifiers": [], "additional_components": [ "Q95XN6", "WBGene00003080", "P92022", "WBGene00001808", "Q23543", "WBGene00003081", "Q20229", "WBGene00003076", "Q20374", "WBGene00009661", "Q9U1W8", "WBGene00003077", "Q19952", "WBGene00003078", "O18694", "WBGene00003079", "Q95XN6", "WBGene00003080", "P92022", "WBGene00001808", "Q23543", "WBGene00003081", "Q20229", "WBGene00003076", "Q20374", "WBGene00009661", "Q9U1W8", "WBGene00003077", "Q19952", "WBGene00003078", "O18694", "WBGene00003079" ] }, "reaction_10523584": { "compartment": "compartment_70101", "id": "reaction_10523584", "reactome": "R-CEL-429860", "name": "DCP1-DCP2 complex decaps mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10523550", "species_29356" ], "products": [ "species_430004", "species_10523552" ], "modifiers": [ [ "species_10523581", "catalyst" ] ], "additional_components": [ "Q95XN6", "WBGene00003080", "P92022", "WBGene00001808", "Q23543", "WBGene00003081", "Q20229", "WBGene00003076", "Q20374", "WBGene00009661", "Q9U1W8", "WBGene00003077", "Q19952", "WBGene00003078", "O18694", "WBGene00003079", "Q95XN6", "WBGene00003080", "P92022", "WBGene00001808", "Q23543", "WBGene00003081", "Q20229", "WBGene00003076", "Q20374", "WBGene00009661", "Q9U1W8", "WBGene00003077", "Q19952", "WBGene00003078", "O18694", "WBGene00003079", "O62255", "WBGene00003582", "Q21740", "WBGene00011036", "Q8ITV6", "WBGene00021551", "Q9N363", "WBGene00021929", "Q95YF3", "WBGene00000479" ] }, "reaction_10557208": { "compartment": "compartment_70101", "id": "reaction_10557208", "reactome": "R-CEL-5694126", "name": "NT5C3B hydrolyses 7MGP to 7MG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_430042" ], "products": [ "species_29372", "species_5694090" ], "modifiers": [ [ "species_10557205", "catalyst" ] ], "additional_components": [ "WBGene00017775" ] }, "reaction_10523598": { "compartment": "compartment_70101", "id": "reaction_10523598", "reactome": "R-CEL-429961", "name": "DCPS scavenges the 7-methylguanosine cap of mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_429926" ], "products": [ "species_430042", "species_429925" ], "modifiers": [ [ "species_10523595", "catalyst" ] ], "additional_components": [ "WBGene00000940" ] }, "reaction_10523695": { "compartment": "compartment_70101", "id": "reaction_10523695", "reactome": "R-CEL-430028", "name": "Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_429974" ], "products": [ "species_109402", "species_113578", "species_109395", "species_429926", "species_76577" ], "modifiers": [ [ "species_10523692", "catalyst" ] ], "additional_components": [ "Q9BKR2", "WBGene00021613", "A5Z2V7", "WBGene00008533", "Q19103", "WBGene00008502", "Q95XD0", "WBGene00022232", "G5EDS8", "WBGene00009289", "Q95QG7", "WBGene00018305", "Q9N4P9", "WBGene00000202", "G5EG59", "WBGene00000798", "Q17533", "WBGene00007201", "Q20128", "WBGene00018154", "Q9XXD2", "WBGene00012966", "Q17632", "WBGene00001001", "Q93830", "WBGene00010325", "P90922", "WBGene00010622" ] }, "reaction_10567172": { "compartment": "compartment_70101", "id": "reaction_10567172", "reactome": "R-CEL-8874082", "name": "MET phosphorylates PTK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10567169" ], "products": [ "species_29370", "species_10567156" ], "modifiers": [ [ "species_10567169", "catalyst" ] ], "additional_components": [ "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q9XVQ7", "WBGene00008711", "Q95YD4", "WBGene00002213", "Q95YD4", "WBGene00002213", "Q9XVQ7", "WBGene00008711", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q9XVQ7", "WBGene00008711", "Q95YD4", "WBGene00002213" ] }, "reaction_10567165": { "compartment": "compartment_70101", "id": "reaction_10567165", "reactome": "R-CEL-8874080", "name": "SRC phosphorylates PTK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10567156" ], "products": [ "species_10567162", "species_29370" ], "modifiers": [ [ "species_10567156", "catalyst" ] ], "additional_components": [ "Q95YD4", "WBGene00002213", "Q9XVQ7", "WBGene00008711", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q9XVQ7", "WBGene00008711", "Q95YD4", "WBGene00002213", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q95YD4", "WBGene00002213", "Q9XVQ7", "WBGene00008711", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635" ] }, "reaction_10548900": { "compartment": "compartment_876", "id": "reaction_10548900", "reactome": "R-CEL-3965444", "name": "WNT:FZD complex promotes G-protein nucleotide exchange", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10548893" ], "products": [ "species_29420", "species_10548897" ], "modifiers": [ [ "species_10548893", "catalyst" ] ], "additional_components": [ "Q9N532", "WBGene00003238", "G5EDV1", "WBGene00003006", "A0A0K3AWM6", "T23D8.1b", "G5ECQ2", "WBGene00000478", "P51875", "WBGene00001648", "Q21917", "WBGene00001669", "P91907", "WBGene00001677", "Q93743", "WBGene00001668", "Q20907", "WBGene00001670", "O76584", "WBGene00001673", "Q9BIG2", "WBGene00001676", "Q20910", "WBGene00001671", "species_29420", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "Q9N532", "WBGene00003238", "G5EDV1", "WBGene00003006", "A0A0K3AWM6", "T23D8.1b", "G5ECQ2", "WBGene00000478", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "P51875", "WBGene00001648", "Q21917", "WBGene00001669", "P91907", "WBGene00001677", "Q93743", "WBGene00001668", "Q20907", "WBGene00001670", "O76584", "WBGene00001673", "Q9BIG2", "WBGene00001676", "Q20910", "WBGene00001671", "species_29438", "Q9N532", "WBGene00003238", "G5EDV1", "WBGene00003006", "A0A0K3AWM6", "T23D8.1b", "G5ECQ2", "WBGene00000478", "P51875", "WBGene00001648", "Q21917", "WBGene00001669", "P91907", "WBGene00001677", "Q93743", "WBGene00001668", "Q20907", "WBGene00001670", "O76584", "WBGene00001673", "Q9BIG2", "WBGene00001676", "Q20910", "WBGene00001671", "species_29420", "P17343", "WBGene00001679", "P54406", "WBGene00001681" ] }, "reaction_10549076": { "compartment": "compartment_70101", "id": "reaction_10549076", "reactome": "R-CEL-4332358", "name": "Dissociation of CaM and CAMK2 autophosphorylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10549073" ], "products": [ "species_10549071", "species_29370", "species_10508995" ], "modifiers": [ [ "species_10549073", "catalyst" ] ], "additional_components": [ "species_74016", "Q11083", "WBGene00020378", "P04630", "WBGene00000285", "G5EF37", "WBGene00003934", "A0A2C9C3L3", "WBGene00020378", "Q18136", "WBGene00006861", "Q09665", "WBGene00006583", "O02159", "WBGene00020378", "G5EDZ8", "WBGene00000288", "Q94288", "WBGene00000287", "Q09980", "WBGene00017394", "O16305", "WBGene00000552", "G5EEG0", "WBGene00000286", "O62305", "WBGene00006779", "O62305", "WBGene00006779", "species_74016", "Q11083", "WBGene00020378", "P04630", "WBGene00000285", "G5EF37", "WBGene00003934", "A0A2C9C3L3", "WBGene00020378", "Q18136", "WBGene00006861", "Q09665", "WBGene00006583", "O02159", "WBGene00020378", "G5EDZ8", "WBGene00000288", "Q94288", "WBGene00000287", "Q09980", "WBGene00017394", "O16305", "WBGene00000552", "G5EEG0", "WBGene00000286", "species_74016", "Q11083", "WBGene00020378", "P04630", "WBGene00000285", "G5EF37", "WBGene00003934", "A0A2C9C3L3", "WBGene00020378", "Q18136", "WBGene00006861", "Q09665", "WBGene00006583", "O02159", "WBGene00020378", "G5EDZ8", "WBGene00000288", "Q94288", "WBGene00000287", "Q09980", "WBGene00017394", "O16305", "WBGene00000552", "G5EEG0", "WBGene00000286", "O62305", "WBGene00006779" ] }, "reaction_10548902": { "compartment": "compartment_876", "id": "reaction_10548902", "reactome": "R-CEL-3965447", "name": "G-protein subunits dissociate from WNT:FZD complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10548897" ], "products": [ "species_10509165", "species_10548887", "species_10548880" ], "modifiers": [], "additional_components": [ "Q9N532", "WBGene00003238", "G5EDV1", "WBGene00003006", "A0A0K3AWM6", "T23D8.1b", "G5ECQ2", "WBGene00000478", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "P51875", "WBGene00001648", "Q21917", "WBGene00001669", "P91907", "WBGene00001677", "Q93743", "WBGene00001668", "Q20907", "WBGene00001670", "O76584", "WBGene00001673", "Q9BIG2", "WBGene00001676", "Q20910", "WBGene00001671", "species_29438", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "P51875", "WBGene00001648", "Q21917", "WBGene00001669", "P91907", "WBGene00001677", "Q93743", "WBGene00001668", "Q20907", "WBGene00001670", "O76584", "WBGene00001673", "Q9BIG2", "WBGene00001676", "Q20910", "WBGene00001671", "Q9N532", "WBGene00003238", "G5EDV1", "WBGene00003006", "A0A0K3AWM6", "T23D8.1b", "G5ECQ2", "WBGene00000478" ] }, "reaction_10549082": { "compartment": "compartment_70101", "id": "reaction_10549082", "reactome": "R-CEL-4332359", "name": "Active calmodulin binds CAMK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10523903", "species_10508995" ], "products": [ "species_10549078" ], "modifiers": [ [ "species_10549080", "inhibitor" ] ], "additional_components": [ "O62305", "WBGene00006779", "species_74016", "Q11083", "WBGene00020378", "P04630", "WBGene00000285", "G5EF37", "WBGene00003934", "A0A2C9C3L3", "WBGene00020378", "Q18136", "WBGene00006861", "Q09665", "WBGene00006583", "O02159", "WBGene00020378", "G5EDZ8", "WBGene00000288", "Q94288", "WBGene00000287", "Q09980", "WBGene00017394", "O16305", "WBGene00000552", "G5EEG0", "WBGene00000286", "species_74016", "Q11083", "WBGene00020378", "P04630", "WBGene00000285", "G5EF37", "WBGene00003934", "A0A2C9C3L3", "WBGene00020378", "Q18136", "WBGene00006861", "Q09665", "WBGene00006583", "O02159", "WBGene00020378", "G5EDZ8", "WBGene00000288", "Q94288", "WBGene00000287", "Q09980", "WBGene00017394", "O16305", "WBGene00000552", "G5EEG0", "WBGene00000286", "O62305", "WBGene00006779", "species_74016", "Q11083", "WBGene00020378", "P04630", "WBGene00000285", "G5EF37", "WBGene00003934", "A0A2C9C3L3", "WBGene00020378", "Q18136", "WBGene00006861", "Q09665", "WBGene00006583", "O02159", "WBGene00020378", "G5EDZ8", "WBGene00000288", "Q94288", "WBGene00000287", "Q09980", "WBGene00017394", "O16305", "WBGene00000552", "G5EEG0", "WBGene00000286", "P22981", "WBGene00002335" ] }, "reaction_10549228": { "compartment": "compartment_70101", "id": "reaction_10549228", "reactome": "R-CEL-4551465", "name": "Translocation of NFATC1:CaN:CaM to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10549222" ], "products": [ "species_10549226" ], "modifiers": [], "additional_components": [ "species_74016", "Q11083", "WBGene00020378", "P04630", "WBGene00000285", "G5EF37", "WBGene00003934", "A0A2C9C3L3", "WBGene00020378", "Q18136", "WBGene00006861", "Q09665", "WBGene00006583", "O02159", "WBGene00020378", "G5EDZ8", "WBGene00000288", "Q94288", "WBGene00000287", "Q09980", "WBGene00017394", "O16305", "WBGene00000552", "G5EEG0", "WBGene00000286", "species_216785", "Q0G819", "WBGene00006527", "species_912516", "G5EDN6", "WBGene00000554", "species_912516", "Q0G819", "WBGene00006527", "species_216785", "species_74016", "A0A2C9C3L3", "WBGene00020378", "Q09980", "WBGene00017394", "G5EDZ8", "WBGene00000288", "Q11083", "WBGene00020378", "G5EEG0", "WBGene00000286", "Q18136", "WBGene00006861", "G5EF37", "WBGene00003934", "Q94288", "WBGene00000287", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "P04630", "WBGene00000285", "Q09665", "WBGene00006583", "G5EDN6", "WBGene00000554" ] }, "reaction_10545533": { "compartment": "compartment_70101", "id": "reaction_10545533", "reactome": "R-CEL-2730872", "name": "Activation of Calcineurin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10541838", "species_10508995", "species_74016" ], "products": [ "species_10545507" ], "modifiers": [], "additional_components": [ "G5EDN6", "WBGene00000554", "species_216785", "Q0G819", "WBGene00006527", "species_912516", "species_74016", "Q11083", "WBGene00020378", "P04630", "WBGene00000285", "G5EF37", "WBGene00003934", "A0A2C9C3L3", "WBGene00020378", "Q18136", "WBGene00006861", "Q09665", "WBGene00006583", "O02159", "WBGene00020378", "G5EDZ8", "WBGene00000288", "Q94288", "WBGene00000287", "Q09980", "WBGene00017394", "O16305", "WBGene00000552", "G5EEG0", "WBGene00000286", "species_74016", "Q11083", "WBGene00020378", "P04630", "WBGene00000285", "G5EF37", "WBGene00003934", "A0A2C9C3L3", "WBGene00020378", "Q18136", "WBGene00006861", "Q09665", "WBGene00006583", "O02159", "WBGene00020378", "G5EDZ8", "WBGene00000288", "Q94288", "WBGene00000287", "Q09980", "WBGene00017394", "O16305", "WBGene00000552", "G5EEG0", "WBGene00000286", "species_216785", "Q0G819", "WBGene00006527", "species_912516", "G5EDN6", "WBGene00000554" ] }, "reaction_10549086": { "compartment": "compartment_70101", "id": "reaction_10549086", "reactome": "R-CEL-4332363", "name": "Autophosphorylation and activation of CAMK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10549078" ], "products": [ "species_29370", "species_10549073" ], "modifiers": [ [ "species_10549078", "catalyst" ] ], "additional_components": [ "species_74016", "Q11083", "WBGene00020378", "P04630", "WBGene00000285", "G5EF37", "WBGene00003934", "A0A2C9C3L3", "WBGene00020378", "Q18136", "WBGene00006861", "Q09665", "WBGene00006583", "O02159", "WBGene00020378", "G5EDZ8", "WBGene00000288", "Q94288", "WBGene00000287", "Q09980", "WBGene00017394", "O16305", "WBGene00000552", "G5EEG0", "WBGene00000286", "O62305", "WBGene00006779", "species_74016", "Q11083", "WBGene00020378", "P04630", "WBGene00000285", "G5EF37", "WBGene00003934", "A0A2C9C3L3", "WBGene00020378", "Q18136", "WBGene00006861", "Q09665", "WBGene00006583", "O02159", "WBGene00020378", "G5EDZ8", "WBGene00000288", "Q94288", "WBGene00000287", "Q09980", "WBGene00017394", "O16305", "WBGene00000552", "G5EEG0", "WBGene00000286", "O62305", "WBGene00006779", "species_74016", "Q11083", "WBGene00020378", "P04630", "WBGene00000285", "G5EF37", "WBGene00003934", "A0A2C9C3L3", "WBGene00020378", "Q18136", "WBGene00006861", "Q09665", "WBGene00006583", "O02159", "WBGene00020378", "G5EDZ8", "WBGene00000288", "Q94288", "WBGene00000287", "Q09980", "WBGene00017394", "O16305", "WBGene00000552", "G5EEG0", "WBGene00000286", "O62305", "WBGene00006779" ] }, "reaction_10549150": { "compartment": "compartment_7660", "id": "reaction_10549150", "reactome": "R-CEL-4411383", "name": "NLK phosphorylates TCF/LEF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10549137" ], "products": [ "species_113582", "species_10549147" ], "modifiers": [ [ "species_10549133", "catalyst" ] ], "additional_components": [ "Q10666", "WBGene00004077", "O44326", "WBGene00001979", "Q10666", "WBGene00004077", "O44326", "WBGene00001979", "Q9U9Y8", "WBGene00003048" ] }, "reaction_10549135": { "compartment": "compartment_7660", "id": "reaction_10549135", "reactome": "R-CEL-4411373", "name": "NLK translocates to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10549129" ], "products": [ "species_10549133" ], "modifiers": [], "additional_components": [ "Q9U9Y8", "WBGene00003048", "Q9U9Y8", "WBGene00003048" ] }, "reaction_10508197": { "compartment": "compartment_5460", "id": "reaction_10508197", "reactome": "R-CEL-77254", "name": "(S)-3-Hydroxydodecanoyl-CoA+NAD<=>3-Oxododecanoyl-CoA+NADH+H", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113526", "species_77252" ], "products": [ "species_113529", "species_77253", "species_29362" ], "modifiers": [ [ "species_10508194", "catalyst" ] ], "additional_components": [ "P41938", "WBGene00007129" ] }, "reaction_10508199": { "compartment": "compartment_5460", "id": "reaction_10508199", "reactome": "R-CEL-77256", "name": "2-trans-Dodecenoyl-CoA+H2O<=>(S)-3-Hydroxydodecanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77255", "species_113521" ], "products": [ "species_77252" ], "modifiers": [ [ "species_10503463", "catalyst" ] ], "additional_components": [ "P34559", "WBGene00001155" ] }, "reaction_10508238": { "compartment": "compartment_5460", "id": "reaction_10508238", "reactome": "R-CEL-77309", "name": "3-Oxododecanoyl-CoA+CoA-SH<=>Decanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_77253" ], "products": [ "species_77308", "species_113559" ], "modifiers": [ [ "species_10508211", "catalyst" ] ], "additional_components": [ "P34255", "WBGene00015125", "Q9GYT0", "WBGene00020347" ] }, "reaction_10570192": { "compartment": "compartment_161320", "id": "reaction_10570192", "reactome": "R-CEL-8963864", "name": "CUBN dissociates from 25(OH)D", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10570190" ], "products": [ "species_10570188", "species_350136" ], "modifiers": [], "additional_components": [ "Q93212", "WBGene00004944", "species_8963879", "WBGene00004944" ] }, "reaction_10516418": { "compartment": "compartment_70101", "id": "reaction_10516418", "reactome": "R-CEL-209845", "name": "CYP2R1 25-hydroxylates VD3 to 25(OH)D", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29368", "species_8963870", "species_29364" ], "products": [ "species_8963879", "species_29356", "species_29366" ], "modifiers": [ [ "species_10516415", "catalyst" ] ], "additional_components": [ "WBGene00016768" ] }, "reaction_10516354": { "compartment": "compartment_70616", "id": "reaction_10516354", "reactome": "R-CEL-209765", "name": "CYP24A1 hydroxylates 1,25(OH)2D, inactivating it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_209800", "species_29368", "species_29364" ], "products": [ "species_29356", "species_350159", "species_29366" ], "modifiers": [ [ "species_10516351", "catalyst" ], [ "species_29532", "catalyst" ] ], "additional_components": [ "G5EGT6", "WBGene00010354", "O17851", "WBGene00009226", "O45219", "WBGene00007140", "Q09660", "WBGene00000375", "Q9N525", "WBGene00021412", "Q9N574", "WBGene00021200", "Q9XVA6", "WBGene00008499", "G5EC97", "WBGene00011830" ] }, "reaction_10570196": { "compartment": "compartment_7660", "id": "reaction_10570196", "reactome": "R-CEL-8963915", "name": "1,25(OH)2D binds VDR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10519369", "species_8963912" ], "products": [ "species_10570194" ], "modifiers": [], "additional_components": [ "Q94407", "WBGene00003638", "Q9XYB7", "WBGene00003607", "G5EFF5", "WBGene00000908", "species_8963912", "Q94407", "WBGene00003638", "Q9XYB7", "WBGene00003607", "G5EFF5", "WBGene00000908" ] }, "reaction_10551658": { "compartment": "compartment_7660", "id": "reaction_10551658", "reactome": "R-CEL-5358592", "name": "DNA ligase I ligates single stranded nick in double stranded DNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_5358610" ], "products": [ "species_109966", "species_164121", "species_113541" ], "modifiers": [ [ "species_10502732", "catalyst" ] ], "additional_components": [ "WBGene00002985" ] }, "reaction_10544314": { "compartment": "compartment_876", "id": "reaction_10544314", "reactome": "R-CEL-2465890", "name": "DDR2 binds collagen type I, II, III, V, X fibrils", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10544310", "species_10544308" ], "products": [ "species_10544312" ], "modifiers": [], "additional_components": [ "Q9N4U2", "WBGene00000647", "O76368", "WBGene00000674", "Q09457", "WBGene00000251", "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689", "P17140", "WBGene00002280", "Q95ZV7", "WBGene00017381", "Q95ZV7", "WBGene00017381", "Q9N4U2", "WBGene00000647", "O76368", "WBGene00000674", "Q09457", "WBGene00000251", "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689", "P17140", "WBGene00002280" ] }, "reaction_10543934": { "compartment": "compartment_876", "id": "reaction_10543934", "reactome": "R-CEL-2327738", "name": "DDR1 binds collagen type I, II, III, IV, V, XI fibrils", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10543930", "species_10543928" ], "products": [ "species_10543932" ], "modifiers": [], "additional_components": [ "Q9N4U2", "WBGene00000647", "O76368", "WBGene00000674", "Q09457", "WBGene00000251", "P17140", "WBGene00002280", "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689", "Q95ZV7", "WBGene00017381", "Q95ZV7", "WBGene00017381", "Q9N4U2", "WBGene00000647", "O76368", "WBGene00000674", "Q09457", "WBGene00000251", "P17140", "WBGene00002280", "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689" ] }, "reaction_10508096": { "compartment": "compartment_17960", "id": "reaction_10508096", "reactome": "R-CEL-76466", "name": "CYP4A11 12-hydroxylates DDCX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_33549", "species_113601" ], "products": [ "species_113519", "species_113564", "species_42373" ], "modifiers": [ [ "species_10508093", "catalyst" ] ], "additional_components": [ "Q9N525", "WBGene00021412", "O17851", "WBGene00009226", "Q9N574", "WBGene00021200", "O45219", "WBGene00007140", "G5EC97", "WBGene00011830", "Q9XVA6", "WBGene00008499", "Q09660", "WBGene00000375", "G5EGT6", "WBGene00010354" ] }, "reaction_10516947": { "compartment": "compartment_17960", "id": "reaction_10516947", "reactome": "R-CEL-211904", "name": "CYP4F12 18-hydroxylates ARA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_140356", "species_113601" ], "products": [ "species_113519", "species_113564", "species_352318" ], "modifiers": [ [ "species_10516944", "catalyst" ] ], "additional_components": [ "G5EC97", "WBGene00011830", "O17851", "WBGene00009226", "G5EGT6", "WBGene00010354", "O45219", "WBGene00007140", "Q9N574", "WBGene00021200", "Q09660", "WBGene00000375", "Q9N525", "WBGene00021412", "Q9XVA6", "WBGene00008499" ] }, "reaction_10517062": { "compartment": "compartment_17960", "id": "reaction_10517062", "reactome": "R-CEL-211983", "name": "CYP2J2 oxidises ARA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_140356", "species_113601" ], "products": [ "species_113519", "species_113564", "species_215062" ], "modifiers": [ [ "species_10517059", "catalyst" ] ], "additional_components": [ "CHEBI:34130", "CHEBI:34157", "species_2142739", "CHEBI:34490", "O45659", "WBGene00010589", "O61204", "WBGene00015045", "O61935", "WBGene00020386", "O62377", "WBGene00011699", "O62378", "WBGene00011698", "P90771", "WBGene00007913", "Q20315", "WBGene00018333", "A0A0M7RF98", "WBGene00018264", "Q27465", "WBGene00015135", "G5ECD0", "WBGene00007362", "Q27470", "WBGene00015709", "G5EE22", "WBGene00012448", "Q27471", "WBGene00016092", "H2KY69", "WBGene00015044", "Q27482", "WBGene00016768", "H2KYS3", "WBGene00000905", "Q27499", "WBGene00018334", "O02627", "WBGene00015399", "Q965T7", "WBGene00021710", "O02628", "WBGene00015400", "Q9N4Q4", "WBGene00021168", "O02641", "WBGene00019967", "Q9N5I1", "WBGene00019565", "O16220", "WBGene00016786", "O16362", "WBGene00018413", "O16482", "WBGene00016860", "O16670", "WBGene00018262", "O16671", "WBGene00018261", "O16673", "WBGene00018260", "O44649", "WBGene00019473", "O44650", "WBGene00019472", "O44651", "WBGene00019471", "O44652", "WBGene00019470", "O44655", "WBGene00015040", "O44656", "WBGene00015041", "O44657", "WBGene00015042", "O44658", "WBGene00015043", "O44704", "WBGene00016686", "O44706", "WBGene00016697", "O45364", "WBGene00008829" ] }, "reaction_10516957": { "compartment": "compartment_17960", "id": "reaction_10516957", "reactome": "R-CEL-211924", "name": "CYP4B1 12-hydroxylates ARA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_140356", "species_113601" ], "products": [ "species_113519", "species_113564", "species_215075" ], "modifiers": [ [ "species_10516954", "catalyst" ] ], "additional_components": [ "G5EC97", "WBGene00011830", "G5EGT6", "WBGene00010354", "O17851", "WBGene00009226", "O45219", "WBGene00007140", "Q09660", "WBGene00000375", "Q9N525", "WBGene00021412", "Q9N574", "WBGene00021200", "Q9XVA6", "WBGene00008499" ] }, "reaction_10558194": { "compartment": "compartment_12045", "id": "reaction_10558194", "reactome": "R-CEL-6786239", "name": "CYP4V2 omega-hydroxylates DHA to HDoHE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_6786220", "species_29368", "species_29364" ], "products": [ "species_29356", "species_29366", "species_6786225" ], "modifiers": [ [ "species_10558191", "catalyst" ] ], "additional_components": [ "WBGene00013585" ] }, "reaction_10513355": { "compartment": "compartment_70101", "id": "reaction_10513355", "reactome": "R-CEL-193060", "name": "CYP19A1 hydroxylates ANDST to E1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29368", "species_193079", "species_29364" ], "products": [ "species_29356", "species_193066", "species_29366", "species_29460" ], "modifiers": [ [ "species_10513352", "catalyst" ] ], "additional_components": [ "Q09660", "WBGene00000375", "Q9N525", "WBGene00021412", "Q9N574", "WBGene00021200", "Q9XVA6", "WBGene00008499", "G5EC97", "WBGene00011830", "G5EGT6", "WBGene00010354", "O17851", "WBGene00009226", "O45219", "WBGene00007140" ] }, "reaction_10516928": { "compartment": "compartment_12045", "id": "reaction_10516928", "reactome": "R-CEL-211873", "name": "CYP4F2, 4F3 20-hydroxylate LTB4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_266056", "species_70106", "species_29368", "species_29364" ], "products": [ "species_29356", "species_29366", "species_2161636" ], "modifiers": [ [ "species_10516925", "catalyst" ] ], "additional_components": [ "Q9XVA6", "WBGene00008499", "G5EC97", "WBGene00011830", "G5EGT6", "WBGene00010354", "O17851", "WBGene00009226", "O45219", "WBGene00007140", "Q09660", "WBGene00000375", "Q9N525", "WBGene00021412", "Q9N574", "WBGene00021200" ] }, "reaction_10552597": { "compartment": "compartment_12045", "id": "reaction_10552597", "reactome": "R-CEL-5602295", "name": "CYP4F22 20-hydroxylates TrXA3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_2142713", "species_29368", "species_29364" ], "products": [ "species_5602281", "species_29356", "species_29366" ], "modifiers": [ [ "species_10508091", "catalyst" ] ], "additional_components": [ "O45219", "WBGene00007140", "Q09660", "WBGene00000375", "Q9N525", "WBGene00021412", "Q9N574", "WBGene00021200", "Q9XVA6", "WBGene00008499", "G5EC97", "WBGene00011830", "G5EGT6", "WBGene00010354", "O17851", "WBGene00009226" ] }, "reaction_10516952": { "compartment": "compartment_17960", "id": "reaction_10516952", "reactome": "R-CEL-211919", "name": "CYP4F8 19-hydroxylates PGH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_30138", "species_113601" ], "products": [ "species_113519", "species_113564", "species_215545" ], "modifiers": [ [ "species_10516949", "catalyst" ] ], "additional_components": [ "Q9XVA6", "WBGene00008499", "G5EC97", "WBGene00011830", "G5EGT6", "WBGene00010354", "O17851", "WBGene00009226", "O45219", "WBGene00007140", "Q09660", "WBGene00000375", "Q9N525", "WBGene00021412", "Q9N574", "WBGene00021200" ] }, "reaction_10517164": { "compartment": "compartment_17960", "id": "reaction_10517164", "reactome": "R-CEL-215526", "name": "CYP4F3 20-hydroxylates LTB4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_215557", "species_113601" ], "products": [ "species_113519", "species_113564", "species_571314" ], "modifiers": [ [ "species_10516925", "catalyst" ] ], "additional_components": [ "Q9XVA6", "WBGene00008499", "G5EC97", "WBGene00011830", "G5EGT6", "WBGene00010354", "O17851", "WBGene00009226", "O45219", "WBGene00007140", "Q09660", "WBGene00000375", "Q9N525", "WBGene00021412", "Q9N574", "WBGene00021200" ] }, "reaction_10516959": { "compartment": "compartment_5460", "id": "reaction_10516959", "reactome": "R-CEL-211950", "name": "CYP24A1 24-hydroxylates CTL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113533", "species_113529", "species_215607", "species_113600" ], "products": [ "species_113563", "species_215622", "species_113521" ], "modifiers": [ [ "species_10516351", "catalyst" ] ], "additional_components": [ "G5EGT6", "WBGene00010354", "O17851", "WBGene00009226", "O45219", "WBGene00007140", "Q09660", "WBGene00000375", "Q9N525", "WBGene00021412", "Q9N574", "WBGene00021200", "Q9XVA6", "WBGene00008499", "G5EC97", "WBGene00011830" ] }, "reaction_10507989": { "compartment": "compartment_12045", "id": "reaction_10507989", "reactome": "R-CEL-76456", "name": "O-atom dealkylation of dextromethorphan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_39703", "species_113601" ], "products": [ "species_143501", "species_113519", "species_113564", "species_76455" ], "modifiers": [ [ "species_10507986", "catalyst" ] ], "additional_components": [ "Q965T7", "WBGene00021710", "O16671", "WBGene00018261", "O45659", "WBGene00010589", "Q9N4Q4", "WBGene00021168", "A0A0M7RF98", "WBGene00018264", "O16673", "WBGene00018260", "O61204", "WBGene00015045", "Q9N5I1", "WBGene00019565", "G5ECD0", "WBGene00007362", "O44649", "WBGene00019473", "O61935", "WBGene00020386", "G5EE22", "WBGene00012448", "O44650", "WBGene00019472", "O62377", "WBGene00011699", "H2KY69", "WBGene00015044", "O44651", "WBGene00019471", "O62378", "WBGene00011698", "H2KYS3", "WBGene00000905", "O44652", "WBGene00019470", "P90771", "WBGene00007913", "O02627", "WBGene00015399", "O44655", "WBGene00015040", "Q20315", "WBGene00018333", "O02628", "WBGene00015400", "O44656", "WBGene00015041", "Q27465", "WBGene00015135", "O02641", "WBGene00019967", "O44657", "WBGene00015042", "Q27470", "WBGene00015709", "O16220", "WBGene00016786", "O44658", "WBGene00015043", "Q27471", "WBGene00016092", "O16362", "WBGene00018413", "O44704", "WBGene00016686", "Q27482", "WBGene00016768", "O16482", "WBGene00016860", "O44706", "WBGene00016697", "Q27499", "WBGene00018334", "O16670", "WBGene00018262", "O45364", "WBGene00008829" ] }, "reaction_10517052": { "compartment": "compartment_12045", "id": "reaction_10517052", "reactome": "R-CEL-211966", "name": "CYP2D6 4-hydroxylates debrisoquine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_211993", "species_113601" ], "products": [ "species_113519", "species_113564", "species_211952" ], "modifiers": [ [ "species_10507986", "catalyst" ] ], "additional_components": [ "Q965T7", "WBGene00021710", "O16671", "WBGene00018261", "O45659", "WBGene00010589", "Q9N4Q4", "WBGene00021168", "A0A0M7RF98", "WBGene00018264", "O16673", "WBGene00018260", "O61204", "WBGene00015045", "Q9N5I1", "WBGene00019565", "G5ECD0", "WBGene00007362", "O44649", "WBGene00019473", "O61935", "WBGene00020386", "G5EE22", "WBGene00012448", "O44650", "WBGene00019472", "O62377", "WBGene00011699", "H2KY69", "WBGene00015044", "O44651", "WBGene00019471", "O62378", "WBGene00011698", "H2KYS3", "WBGene00000905", "O44652", "WBGene00019470", "P90771", "WBGene00007913", "O02627", "WBGene00015399", "O44655", "WBGene00015040", "Q20315", "WBGene00018333", "O02628", "WBGene00015400", "O44656", "WBGene00015041", "Q27465", "WBGene00015135", "O02641", "WBGene00019967", "O44657", "WBGene00015042", "Q27470", "WBGene00015709", "O16220", "WBGene00016786", "O44658", "WBGene00015043", "Q27471", "WBGene00016092", "O16362", "WBGene00018413", "O44704", "WBGene00016686", "Q27482", "WBGene00016768", "O16482", "WBGene00016860", "O44706", "WBGene00016697", "Q27499", "WBGene00018334", "O16670", "WBGene00018262", "O45364", "WBGene00008829" ] }, "reaction_10517057": { "compartment": "compartment_17960", "id": "reaction_10517057", "reactome": "R-CEL-211968", "name": "CYP2W1 oxidises INDOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_113601", "species_216547" ], "products": [ "species_113519", "species_113564", "species_216598" ], "modifiers": [ [ "species_10517054", "catalyst" ] ], "additional_components": [ "O44651", "WBGene00019471", "O44652", "WBGene00019470", "O44655", "WBGene00015040", "O44656", "WBGene00015041", "O44657", "WBGene00015042", "O44658", "WBGene00015043", "O44704", "WBGene00016686", "O44706", "WBGene00016697", "O45364", "WBGene00008829", "O45659", "WBGene00010589", "O61204", "WBGene00015045", "O61935", "WBGene00020386", "O62377", "WBGene00011699", "O62378", "WBGene00011698", "P90771", "WBGene00007913", "Q20315", "WBGene00018333", "A0A0M7RF98", "WBGene00018264", "Q27465", "WBGene00015135", "G5ECD0", "WBGene00007362", "Q27470", "WBGene00015709", "G5EE22", "WBGene00012448", "Q27471", "WBGene00016092", "H2KY69", "WBGene00015044", "Q27482", "WBGene00016768", "H2KYS3", "WBGene00000905", "Q27499", "WBGene00018334", "O02627", "WBGene00015399", "Q965T7", "WBGene00021710", "O02628", "WBGene00015400", "Q9N4Q4", "WBGene00021168", "O02641", "WBGene00019967", "Q9N5I1", "WBGene00019565", "O16220", "WBGene00016786", "O16362", "WBGene00018413", "O16482", "WBGene00016860", "O16670", "WBGene00018262", "O16671", "WBGene00018261", "O16673", "WBGene00018260", "O44649", "WBGene00019473", "O44650", "WBGene00019472" ] }, "reaction_10517044": { "compartment": "compartment_17960", "id": "reaction_10517044", "reactome": "R-CEL-211960", "name": "CYP2U1 19-hydroxylates ARA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_140356", "species_113601" ], "products": [ "species_216620", "species_113519", "species_113564" ], "modifiers": [ [ "species_10517041", "catalyst" ] ], "additional_components": [ "A0A0M7RF98", "WBGene00018264", "Q27465", "WBGene00015135", "G5ECD0", "WBGene00007362", "Q27470", "WBGene00015709", "G5EE22", "WBGene00012448", "Q27471", "WBGene00016092", "H2KY69", "WBGene00015044", "Q27482", "WBGene00016768", "H2KYS3", "WBGene00000905", "Q27499", "WBGene00018334", "O02627", "WBGene00015399", "Q965T7", "WBGene00021710", "O02628", "WBGene00015400", "Q9N4Q4", "WBGene00021168", "O02641", "WBGene00019967", "Q9N5I1", "WBGene00019565", "O16220", "WBGene00016786", "O16362", "WBGene00018413", "O16482", "WBGene00016860", "O16670", "WBGene00018262", "O16671", "WBGene00018261", "O16673", "WBGene00018260", "O44649", "WBGene00019473", "O44650", "WBGene00019472", "O44651", "WBGene00019471", "O44652", "WBGene00019470", "O44655", "WBGene00015040", "O44656", "WBGene00015041", "O44657", "WBGene00015042", "O44658", "WBGene00015043", "O44704", "WBGene00016686", "O44706", "WBGene00016697", "O45364", "WBGene00008829", "O45659", "WBGene00010589", "O61204", "WBGene00015045", "O61935", "WBGene00020386", "O62377", "WBGene00011699", "O62378", "WBGene00011698", "P90771", "WBGene00007913", "Q20315", "WBGene00018333" ] }, "reaction_10517049": { "compartment": "compartment_17960", "id": "reaction_10517049", "reactome": "R-CEL-211962", "name": "CYP4F11 16-hydroxylates 3OH-PALM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_216621", "species_113601" ], "products": [ "species_113519", "species_113564", "species_216612" ], "modifiers": [ [ "species_10517046", "catalyst" ] ], "additional_components": [ "G5EGT6", "WBGene00010354", "Q9N574", "WBGene00021200" ] }, "reaction_10545531": { "compartment": "compartment_70101", "id": "reaction_10545531", "reactome": "R-CEL-2730867", "name": "Translocation of CaN:CaM:NFAT to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10545511" ], "products": [ "species_10545529" ], "modifiers": [], "additional_components": [ "species_74016", "Q11083", "WBGene00020378", "P04630", "WBGene00000285", "G5EF37", "WBGene00003934", "A0A2C9C3L3", "WBGene00020378", "Q18136", "WBGene00006861", "Q09665", "WBGene00006583", "O02159", "WBGene00020378", "G5EDZ8", "WBGene00000288", "Q94288", "WBGene00000287", "Q09980", "WBGene00017394", "O16305", "WBGene00000552", "G5EEG0", "WBGene00000286", "species_216785", "Q0G819", "WBGene00006527", "species_912516", "G5EDN6", "WBGene00000554", "species_912516", "Q0G819", "WBGene00006527", "species_216785", "species_74016", "A0A2C9C3L3", "WBGene00020378", "Q09980", "WBGene00017394", "G5EDZ8", "WBGene00000288", "Q11083", "WBGene00020378", "G5EEG0", "WBGene00000286", "Q18136", "WBGene00006861", "G5EF37", "WBGene00003934", "Q94288", "WBGene00000287", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "P04630", "WBGene00000285", "Q09665", "WBGene00006583", "G5EDN6", "WBGene00000554" ] }, "reaction_10544706": { "compartment": "compartment_2514888", "id": "reaction_10544706", "reactome": "R-CEL-2485182", "name": "Gt-GTP dissociates to GNAT1-GTP and GNB1:GNGT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10544704" ], "products": [ "species_10544702", "species_10544695" ], "modifiers": [], "additional_components": [ "Q9BIG2", "WBGene00001676", "P91907", "WBGene00001677", "Q20907", "WBGene00001670", "Q20910", "WBGene00001671", "Q21917", "WBGene00001669", "Q93743", "WBGene00001668", "O76584", "WBGene00001673", "species_29438", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "Q9BIG2", "WBGene00001676", "P91907", "WBGene00001677", "Q20907", "WBGene00001670", "Q20910", "WBGene00001671", "Q21917", "WBGene00001669", "Q93743", "WBGene00001668", "O76584", "WBGene00001673", "species_29438" ] }, "reaction_10544724": { "compartment": "compartment_70101", "id": "reaction_10544724", "reactome": "R-CEL-2514865", "name": "cGMP dissociates from CNG channels", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10506568" ], "products": [ "species_30991", "species_10506566" ], "modifiers": [], "additional_components": [ "G5EEE2", "WBGene00006525", "Q03611", "WBGene00006526", "Q7Z205", "WBGene00000563", "A8WI01", "WBGene00000562", "Q9N4C1", "WBGene00022295", "O61827", "WBGene00000487", "species_30991", "G5EEE2", "WBGene00006525", "Q03611", "WBGene00006526", "Q7Z205", "WBGene00000563", "A8WI01", "WBGene00000562", "Q9N4C1", "WBGene00022295", "O61827", "WBGene00000487" ] }, "reaction_10544727": { "compartment": "compartment_70101", "id": "reaction_10544727", "reactome": "R-CEL-2514867", "name": "cGMP:CNG transports Na+ and Ca2+ into the rod outer segment", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74112", "species_74113" ], "products": [ "species_83910", "species_74016" ], "modifiers": [ [ "species_10506568", "catalyst" ] ], "additional_components": [ "G5EEE2", "WBGene00006525", "Q03611", "WBGene00006526", "Q7Z205", "WBGene00000563", "A8WI01", "WBGene00000562", "Q9N4C1", "WBGene00022295", "O61827", "WBGene00000487", "species_30991" ] }, "reaction_10544802": { "compartment": "compartment_70101", "id": "reaction_10544802", "reactome": "R-CEL-2534087", "name": "NMT1/2 transfer MYS to GNAT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10544792", "species_2534019" ], "products": [ "species_10544691", "species_76194" ], "modifiers": [ [ "species_10544797", "catalyst" ] ], "additional_components": [ "Q20910", "WBGene00001671", "Q21917", "WBGene00001669", "Q93743", "WBGene00001668", "Q9BIG2", "WBGene00001676", "O76584", "WBGene00001673", "P91907", "WBGene00001677", "Q20907", "WBGene00001670", "Q9BIG2", "WBGene00001676", "P91907", "WBGene00001677", "Q20907", "WBGene00001670", "Q20910", "WBGene00001671", "Q21917", "WBGene00001669", "Q93743", "WBGene00001668", "O76584", "WBGene00001673", "WBGene00020549" ] }, "reaction_10544837": { "compartment": "compartment_70101", "id": "reaction_10544837", "reactome": "R-CEL-2534096", "name": "METAP1/2 demethylates GNAT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10544818" ], "products": [ "species_10544792", "species_174390" ], "modifiers": [ [ "species_10544834", "catalyst" ] ], "additional_components": [ "Q9BIG2", "WBGene00001676", "O76584", "WBGene00001673", "P91907", "WBGene00001677", "Q20907", "WBGene00001670", "Q20910", "WBGene00001671", "Q21917", "WBGene00001669", "Q93743", "WBGene00001668", "Q20910", "WBGene00001671", "Q21917", "WBGene00001669", "Q93743", "WBGene00001668", "Q9BIG2", "WBGene00001676", "O76584", "WBGene00001673", "P91907", "WBGene00001677", "Q20907", "WBGene00001670", "species_880069", "H1UBK1", "WBGene00003130", "Q965Y1", "WBGene00003129" ] }, "reaction_10544774": { "compartment": "compartment_2514888", "id": "reaction_10544774", "reactome": "R-CEL-2530501", "name": "FNTA:FNTB transfers FARN to GNGT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10544764", "species_2530486" ], "products": [ "species_111294", "species_10544700" ], "modifiers": [ [ "species_10544771", "catalyst" ] ], "additional_components": [ "WBGene00001681", "WBGene00001681", "Q19752", "WBGene00006465", "O44501", "WBGene00019823" ] }, "reaction_10544918": { "compartment": "compartment_70101", "id": "reaction_10544918", "reactome": "R-CEL-2586748", "name": "GUCA binds Ca2+ to form GUCA:Ca2+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10544904", "species_74016" ], "products": [ "species_10544916" ], "modifiers": [], "additional_components": [ "WBGene00003564", "species_74016", "P36609", "WBGene00003564" ] }, "reaction_10546711": { "compartment": "compartment_70101", "id": "reaction_10546711", "reactome": "R-CEL-3229181", "name": "CALM1:Ca2+ binds CNG channel", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10506566", "species_10508995" ], "products": [ "species_10546709" ], "modifiers": [ [ "species_74016", "catalyst" ] ], "additional_components": [ "G5EEE2", "WBGene00006525", "Q03611", "WBGene00006526", "Q7Z205", "WBGene00000563", "A8WI01", "WBGene00000562", "Q9N4C1", "WBGene00022295", "O61827", "WBGene00000487", "species_74016", "Q11083", "WBGene00020378", "P04630", "WBGene00000285", "G5EF37", "WBGene00003934", "A0A2C9C3L3", "WBGene00020378", "Q18136", "WBGene00006861", "Q09665", "WBGene00006583", "O02159", "WBGene00020378", "G5EDZ8", "WBGene00000288", "Q94288", "WBGene00000287", "Q09980", "WBGene00017394", "O16305", "WBGene00000552", "G5EEG0", "WBGene00000286", "species_74016", "Q11083", "WBGene00020378", "P04630", "WBGene00000285", "G5EF37", "WBGene00003934", "A0A2C9C3L3", "WBGene00020378", "Q18136", "WBGene00006861", "Q09665", "WBGene00006583", "O02159", "WBGene00020378", "G5EDZ8", "WBGene00000288", "Q94288", "WBGene00000287", "Q09980", "WBGene00017394", "O16305", "WBGene00000552", "G5EEG0", "WBGene00000286", "G5EEE2", "WBGene00006525", "Q03611", "WBGene00006526", "Q7Z205", "WBGene00000563", "A8WI01", "WBGene00000562", "Q9N4C1", "WBGene00022295", "O61827", "WBGene00000487" ] }, "reaction_10506570": { "compartment": "compartment_70101", "id": "reaction_10506570", "reactome": "R-CEL-74031", "name": "cGMP binds CNG channel to form cGMP:CNG channel", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30991", "species_10506566" ], "products": [ "species_10506568" ], "modifiers": [], "additional_components": [ "G5EEE2", "WBGene00006525", "Q03611", "WBGene00006526", "Q7Z205", "WBGene00000563", "A8WI01", "WBGene00000562", "Q9N4C1", "WBGene00022295", "O61827", "WBGene00000487", "G5EEE2", "WBGene00006525", "Q03611", "WBGene00006526", "Q7Z205", "WBGene00000563", "A8WI01", "WBGene00000562", "Q9N4C1", "WBGene00022295", "O61827", "WBGene00000487", "species_30991" ] }, "reaction_10544161": { "compartment": "compartment_70101", "id": "reaction_10544161", "reactome": "R-CEL-2404142", "name": "atROL binds RBP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2473616", "species_10506914" ], "products": [ "species_10544159" ], "modifiers": [], "additional_components": [ "O02324", "WBGene00002260", "O01812", "WBGene00002258", "O01814", "WBGene00002257", "O02323", "WBGene00002259", "O02324", "WBGene00002260", "O01812", "WBGene00002258", "O01814", "WBGene00002257", "O02323", "WBGene00002259", "species_5623649" ] }, "reaction_10544130": { "compartment": "compartment_70101", "id": "reaction_10544130", "reactome": "R-CEL-2399913", "name": "atRAL binds to RBP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10530542", "species_975622" ], "products": [ "species_10530546" ], "modifiers": [], "additional_components": [ "O01812", "WBGene00002258", "O01814", "WBGene00002257", "O02323", "WBGene00002259", "O02324", "WBGene00002260", "species_5623648", "O01812", "WBGene00002258", "O01814", "WBGene00002257", "O02323", "WBGene00002259", "O02324", "WBGene00002260" ] }, "reaction_10530532": { "compartment": "compartment_984", "id": "reaction_10530532", "reactome": "R-CEL-975594", "name": "PLB1 hydrolyses RPALM to atROL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_975591" ], "products": [ "species_975590", "species_426576" ], "modifiers": [ [ "species_10530529", "catalyst" ] ], "additional_components": [ "Q8MXQ8", "WBGene00022256", "Q9N2Z4", "WBGene00022256" ] }, "reaction_10530548": { "compartment": "compartment_70101", "id": "reaction_10530548", "reactome": "R-CEL-975633", "name": "atROL binds to RBP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10530542", "species_975590" ], "products": [ "species_10530544" ], "modifiers": [], "additional_components": [ "O01812", "WBGene00002258", "O01814", "WBGene00002257", "O02323", "WBGene00002259", "O02324", "WBGene00002260", "species_5623649", "O01812", "WBGene00002258", "O01814", "WBGene00002257", "O02323", "WBGene00002259", "O02324", "WBGene00002260" ] }, "reaction_10544165": { "compartment": "compartment_70101", "id": "reaction_10544165", "reactome": "R-CEL-2404144", "name": "Parenchymal atROL translocates to HSCs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10544163" ], "products": [ "species_2473616", "species_10506914" ], "modifiers": [], "additional_components": [ "O02324", "WBGene00002260", "O01812", "WBGene00002258", "O01814", "WBGene00002257", "O02323", "WBGene00002259", "species_5623649", "O02324", "WBGene00002260", "O01812", "WBGene00002258", "O01814", "WBGene00002257", "O02323", "WBGene00002259" ] }, "reaction_10530570": { "compartment": "compartment_70101", "id": "reaction_10530570", "reactome": "R-CEL-975635", "name": "BCMO1:Fe2+ cleaves betaC to atRAL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_975643" ], "products": [ "species_975622" ], "modifiers": [ [ "species_10530567", "catalyst" ] ], "additional_components": [ "Q9U2E4", "WBGene00012914", "H2L060", "WBGene00018640", "Q9TXT9", "WBGene00018755", "species_113531" ] }, "reaction_10545931": { "compartment": "compartment_70101", "id": "reaction_10545931", "reactome": "R-CEL-2855252", "name": "AKRs reduce RBP2:atRAL to RBP2:atROL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_10530546" ], "products": [ "species_29366", "species_10530544" ], "modifiers": [ [ "species_10545928", "catalyst" ] ], "additional_components": [ "species_5623648", "O01812", "WBGene00002258", "O01814", "WBGene00002257", "O02323", "WBGene00002259", "O02324", "WBGene00002260", "species_5623649", "O01812", "WBGene00002258", "O01814", "WBGene00002257", "O02323", "WBGene00002259", "O02324", "WBGene00002260", "P91020", "WBGene00016985", "Q18903", "WBGene00016985", "Q23320", "WBGene00016985" ] }, "reaction_10544155": { "compartment": "compartment_984", "id": "reaction_10544155", "reactome": "R-CEL-2404134", "name": "RBP4:atROL binds TTR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10544137", "species_10544151" ], "products": [ "species_10544153" ], "modifiers": [], "additional_components": [ "species_5623649", "G5EEB8", "WBGene00011726", "Q21882", "WBGene00022808", "O44578", "WBGene00022808", "Q21882", "WBGene00022808", "O44578", "WBGene00022808", "species_5623649", "G5EEB8", "WBGene00011726" ] }, "reaction_10545933": { "compartment": "compartment_70101", "id": "reaction_10545933", "reactome": "R-CEL-2855259", "name": "atROL binds RBP1 (parenchymal cell)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2473610", "species_10506914" ], "products": [ "species_10544163" ], "modifiers": [], "additional_components": [ "O02324", "WBGene00002260", "O01812", "WBGene00002258", "O01814", "WBGene00002257", "O02323", "WBGene00002259", "O02324", "WBGene00002260", "O01812", "WBGene00002258", "O01814", "WBGene00002257", "O02323", "WBGene00002259", "species_5623649" ] }, "reaction_10544157": { "compartment": "compartment_984", "id": "reaction_10544157", "reactome": "R-CEL-2404135", "name": "RBP4 binds atROL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10544135", "species_2395761" ], "products": [ "species_10544137" ], "modifiers": [], "additional_components": [ "WBGene00011726", "species_5623649", "G5EEB8", "WBGene00011726" ] }, "reaction_10550030": { "compartment": "compartment_5460", "id": "reaction_10550030", "reactome": "R-CEL-5164399", "name": "BCO2:Fe2+ cleaves betaC to APO10al and bION", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113533", "species_5164389" ], "products": [ "species_5164390", "species_5164383" ], "modifiers": [ [ "species_10550027", "catalyst" ] ], "additional_components": [ "Q9TXT9", "WBGene00018755", "species_113531" ] }, "reaction_10544304": { "compartment": "compartment_70101", "id": "reaction_10544304", "reactome": "R-CEL-2464822", "name": "RDH12 reduces atRAL to atROL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_975622", "species_29364" ], "products": [ "species_2473615", "species_29366" ], "modifiers": [ [ "species_10544301", "catalyst" ] ], "additional_components": [ "WBGene00007780" ] }, "reaction_10506918": { "compartment": "compartment_70101", "id": "reaction_10506918", "reactome": "R-CEL-74843", "name": "atROL binds RBP1 to form RBP1:atROL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10506914", "species_2473604" ], "products": [ "species_10506916" ], "modifiers": [], "additional_components": [ "O02324", "WBGene00002260", "O01812", "WBGene00002258", "O01814", "WBGene00002257", "O02323", "WBGene00002259", "species_5623649", "O02324", "WBGene00002260", "O01812", "WBGene00002258", "O01814", "WBGene00002257", "O02323", "WBGene00002259" ] }, "reaction_10544295": { "compartment": "compartment_70101", "id": "reaction_10544295", "reactome": "R-CEL-2453833", "name": "RPE65 isomero-hydrolyses atREs to 11cROL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_2864099" ], "products": [ "species_30927", "species_2864103", "species_70106" ], "modifiers": [ [ "species_10544287", "catalyst" ], [ "species_10544293", "catalyst" ] ], "additional_components": [ "CHEBI:70762", "species_2534407", "CHEBI:70760", "CHEBI:70761", "CHEBI:16196", "CHEBI:17351", "species_390435", "species_8934421", "H2L060", "WBGene00018640", "Q9TXT9", "WBGene00018755", "Q9U2E4", "WBGene00012914", "WBGene00002039" ] }, "reaction_10544339": { "compartment": "compartment_70101", "id": "reaction_10544339", "reactome": "R-CEL-2465940", "name": "atRAL is reduced to atROL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_975622", "species_29364" ], "products": [ "species_29366", "species_2473607" ], "modifiers": [ [ "species_10544336", "catalyst" ] ], "additional_components": [ "O18030", "WBGene00000968", "Q19843", "WBGene00000992", "Q22392", "WBGene00000982", "A5JYX5", "WBGene00000967" ] }, "reaction_10543792": { "compartment": "compartment_7660", "id": "reaction_10543792", "reactome": "R-CEL-2294600", "name": "CDK1 phosphorylates condensin II subunit NCAPD3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10543756" ], "products": [ "species_113582", "species_10543788" ], "modifiers": [ [ "species_10511241", "catalyst" ] ], "additional_components": [ "P62784", "WBGene00001875", "Q20818", "WBGene00010093", "Q09591", "WBGene00003367", "P34341", "WBGene00016202", "Q20060", "WBGene00004874", "Q95Y84", "WBGene00001833", "Q20818", "WBGene00010093", "Q09591", "WBGene00003367", "Q95Y84", "WBGene00001833", "P34341", "WBGene00016202", "Q20060", "WBGene00004874", "P62784", "WBGene00001875", "O45926", "WBGene00000866", "Q10653", "WBGene00000865", "Q9BLB5", "WBGene00000867", "P34556", "WBGene00000405" ] }, "reaction_10543762": { "compartment": "compartment_7660", "id": "reaction_10543762", "reactome": "R-CEL-2288097", "name": "Condensin II complex binds H4K20me1-containing nucleosomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10543339", "species_10543368" ], "products": [ "species_10543756" ], "modifiers": [ [ "species_10543760", "catalyst" ] ], "additional_components": [ "Q20818", "WBGene00010093", "Q09591", "WBGene00003367", "P34341", "WBGene00016202", "Q20060", "WBGene00004874", "Q95Y84", "WBGene00001833", "P62784", "WBGene00001875", "P62784", "WBGene00001875", "Q20818", "WBGene00010093", "Q09591", "WBGene00003367", "P34341", "WBGene00016202", "Q20060", "WBGene00004874", "Q95Y84", "WBGene00001833", "Q20818", "WBGene00010093", "Q09591", "WBGene00003367", "P34341", "WBGene00016202", "Q20060", "WBGene00004874", "Q95Y84", "WBGene00001833" ] }, "reaction_10543715": { "compartment": "compartment_7660", "id": "reaction_10543715", "reactome": "R-CEL-2245218", "name": "CDK1 phosphorylates PHF8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10543378" ], "products": [ "species_113582", "species_10543368", "species_10543713" ], "modifiers": [ [ "species_10511241", "catalyst" ] ], "additional_components": [ "species_113531", "Q9GYI0", "WBGene00017920", "P62784", "WBGene00001875", "P62784", "WBGene00001875", "species_113531", "Q9GYI0", "WBGene00017920", "O45926", "WBGene00000866", "Q10653", "WBGene00000865", "Q9BLB5", "WBGene00000867", "P34556", "WBGene00000405" ] }, "reaction_10543385": { "compartment": "compartment_7660", "id": "reaction_10543385", "reactome": "R-CEL-2172678", "name": "PHF8 demethylates histone H4K20me1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113671", "species_113685", "species_10543378" ], "products": [ "species_29478", "species_10543382", "species_159942", "species_159939" ], "modifiers": [ [ "species_10543378", "catalyst" ] ], "additional_components": [ "species_113531", "Q9GYI0", "WBGene00017920", "P62784", "WBGene00001875", "species_113531", "Q9GYI0", "WBGene00017920", "P62784", "WBGene00001875", "species_113531", "Q9GYI0", "WBGene00017920", "P62784", "WBGene00001875" ] }, "reaction_10543786": { "compartment": "compartment_7660", "id": "reaction_10543786", "reactome": "R-CEL-2294580", "name": "PLK1 hyperphosphorylates Condensin II complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10543770" ], "products": [ "species_113582", "species_10543783" ], "modifiers": [ [ "species_10543770", "catalyst" ] ], "additional_components": [ "P62784", "WBGene00001875", "Q20818", "WBGene00010093", "Q09591", "WBGene00003367", "Q95Y84", "WBGene00001833", "P34341", "WBGene00016202", "Q20060", "WBGene00004874", "Q9N2L7", "WBGene00004043", "Q20818", "WBGene00010093", "P34341", "WBGene00016202", "Q09591", "WBGene00003367", "Q20060", "WBGene00004874", "Q95Y84", "WBGene00001833", "P62784", "WBGene00001875", "Q9N2L7", "WBGene00004043", "P62784", "WBGene00001875", "Q20818", "WBGene00010093", "Q09591", "WBGene00003367", "Q95Y84", "WBGene00001833", "P34341", "WBGene00016202", "Q20060", "WBGene00004874", "Q9N2L7", "WBGene00004043" ] }, "reaction_10543804": { "compartment": "compartment_7660", "id": "reaction_10543804", "reactome": "R-CEL-2301205", "name": "SETD8 monomethylates histone H4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10543382" ], "products": [ "species_77502", "species_10543378" ], "modifiers": [ [ "species_10543801", "catalyst" ] ], "additional_components": [ "species_113531", "Q9GYI0", "WBGene00017920", "P62784", "WBGene00001875", "species_113531", "Q9GYI0", "WBGene00017920", "P62784", "WBGene00001875", "WBGene00004781" ] }, "reaction_10543790": { "compartment": "compartment_7660", "id": "reaction_10543790", "reactome": "R-CEL-2294590", "name": "PLK1 binds phosphorylated condensin II complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10543788", "species_10509851" ], "products": [ "species_10543770" ], "modifiers": [], "additional_components": [ "Q20818", "WBGene00010093", "Q09591", "WBGene00003367", "Q95Y84", "WBGene00001833", "P34341", "WBGene00016202", "Q20060", "WBGene00004874", "P62784", "WBGene00001875", "WBGene00004043", "P62784", "WBGene00001875", "Q20818", "WBGene00010093", "Q09591", "WBGene00003367", "Q95Y84", "WBGene00001833", "P34341", "WBGene00016202", "Q20060", "WBGene00004874", "Q9N2L7", "WBGene00004043" ] }, "reaction_10543577": { "compartment": "compartment_20699", "id": "reaction_10543577", "reactome": "R-CEL-2214351", "name": "PLK1 phosphorylates GORASP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10543569" ], "products": [ "species_29370", "species_10543574" ], "modifiers": [ [ "species_10543569", "catalyst" ] ], "additional_components": [ "Q9N2L7", "WBGene00004043", "Q19989", "WBGene00018017", "Q9N3Y1", "WBGene00021536", "Q9UAQ6", "WBGene00004266", "species_29438", "Q19989", "WBGene00018017", "Q9N3Y1", "WBGene00021536", "Q9N2L7", "WBGene00004043", "Q9UAQ6", "WBGene00004266", "species_29438", "Q9N2L7", "WBGene00004043", "Q19989", "WBGene00018017", "Q9N3Y1", "WBGene00021536", "Q9UAQ6", "WBGene00004266", "species_29438" ] }, "reaction_10544207": { "compartment": "compartment_20699", "id": "reaction_10544207", "reactome": "R-CEL-2422927", "name": "MAPK3-3 or MAPK1 phosphorylate GORASP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10544192" ], "products": [ "species_29370", "species_10544198" ], "modifiers": [ [ "species_10544204", "catalyst" ] ], "additional_components": [ "Q9N3Y1", "WBGene00021536", "Q21954", "WBGene00020018", "A0A2C9C2Y0", "WBGene00006833", "species_29438", "Q9N3Y1", "WBGene00021536", "Q21954", "WBGene00020018", "A0A2C9C2Y0", "WBGene00006833", "species_29438" ] }, "reaction_10514372": { "compartment": "compartment_7660", "id": "reaction_10514372", "reactome": "R-CEL-199839", "name": "AKT can phosphorylate RSK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10514366" ], "products": [ "species_113582", "species_10514370" ], "modifiers": [ [ "species_10514266", "catalyst" ] ], "additional_components": [ "WBGene00012929", "WBGene00012929", "G4S4W1", "WBGene00016980", "Q17941", "WBGene00000102", "Q9XTG7", "WBGene00000103" ] }, "reaction_10514300": { "compartment": "compartment_7660", "id": "reaction_10514300", "reactome": "R-CEL-199299", "name": "AKT phosphorylates FOXO transcription factors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10514274" ], "products": [ "species_113582", "species_10514285" ], "modifiers": [ [ "species_10514266", "catalyst" ] ], "additional_components": [ "WBGene00000912", "WBGene00000912", "G4S4W1", "WBGene00016980", "Q17941", "WBGene00000102", "Q9XTG7", "WBGene00000103" ] }, "reaction_10514269": { "compartment": "compartment_7660", "id": "reaction_10514269", "reactome": "R-CEL-199298", "name": "AKT phosphorylates CREB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10514243" ], "products": [ "species_113582", "species_10514246" ], "modifiers": [ [ "species_10514266", "catalyst" ] ], "additional_components": [ "WBGene00000793", "WBGene00000793", "G4S4W1", "WBGene00016980", "Q17941", "WBGene00000102", "Q9XTG7", "WBGene00000103" ] }, "reaction_10514382": { "compartment": "compartment_7660", "id": "reaction_10514382", "reactome": "R-CEL-199863", "name": "AKT can phosphorylate NR4A1 (NUR77)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10514377" ], "products": [ "species_113582", "species_10514380" ], "modifiers": [ [ "species_10514266", "catalyst" ] ], "additional_components": [ "WBGene00003605", "WBGene00003605", "G4S4W1", "WBGene00016980", "Q17941", "WBGene00000102", "Q9XTG7", "WBGene00000103" ] }, "reaction_10571544": { "compartment": "compartment_70101", "id": "reaction_10571544", "reactome": "R-CEL-9027043", "name": "CYPs hydroxylate DHA to 14(R)-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29368", "species_29364", "species_9024011" ], "products": [ "species_29356", "species_29366", "species_9027049" ], "modifiers": [ [ "species_10507820", "catalyst" ] ], "additional_components": [ "Q965T7", "WBGene00021710", "O16671", "WBGene00018261", "O45659", "WBGene00010589", "Q9N4Q4", "WBGene00021168", "A0A0M7RF98", "WBGene00018264", "O16673", "WBGene00018260", "O61204", "WBGene00015045", "Q9N5I1", "WBGene00019565", "G5ECD0", "WBGene00007362", "O44649", "WBGene00019473", "O61935", "WBGene00020386", "G5EE22", "WBGene00012448", "O44650", "WBGene00019472", "O62377", "WBGene00011699", "H2KY69", "WBGene00015044", "O44651", "WBGene00019471", "O62378", "WBGene00011698", "H2KYS3", "WBGene00000905", "O44652", "WBGene00019470", "P90771", "WBGene00007913", "O02627", "WBGene00015399", "O44655", "WBGene00015040", "Q20315", "WBGene00018333", "O02628", "WBGene00015400", "O44656", "WBGene00015041", "Q27465", "WBGene00015135", "O02641", "WBGene00019967", "O44657", "WBGene00015042", "Q27470", "WBGene00015709", "O16220", "WBGene00016786", "O44658", "WBGene00015043", "Q27471", "WBGene00016092", "O16362", "WBGene00018413", "O44704", "WBGene00016686", "Q27482", "WBGene00016768", "O16482", "WBGene00016860", "O44706", "WBGene00016697", "Q27499", "WBGene00018334", "O16670", "WBGene00018262", "O45364", "WBGene00008829" ] }, "reaction_10523346": { "compartment": "compartment_70101", "id": "reaction_10523346", "reactome": "R-CEL-428941", "name": "P2Y purinoceptor 1 activates MAP kinase p38 alpha", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10523344" ], "products": [ "species_10512654", "species_29370" ], "modifiers": [ [ "species_10508937", "catalyst" ] ], "additional_components": [ "WBGene00004055", "WBGene00004055", "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196", "species_29438" ] }, "reaction_10521881": { "compartment": "compartment_70101", "id": "reaction_10521881", "reactome": "R-CEL-418662", "name": "Src activation following P2Y purinoceptor activation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10513079" ], "products": [ "species_10518252" ], "modifiers": [], "additional_components": [ "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635" ] }, "reaction_10556833": { "compartment": "compartment_70101", "id": "reaction_10556833", "reactome": "R-CEL-5691431", "name": "PSMD14 cleaves K63-linked ubiquitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10511035" ], "products": [ "species_10511033" ], "modifiers": [ [ "species_10502380", "catalyst" ] ], "additional_components": [ "P37165", "WBGene00006725", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "WBGene00004467" ] }, "reaction_10556830": { "compartment": "compartment_7660", "id": "reaction_10556830", "reactome": "R-CEL-5691381", "name": "MYSM1 deubiquitinates Histone H2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10556825" ], "products": [ "species_10502318", "species_10556827" ], "modifiers": [ [ "species_10556825", "catalyst" ] ], "additional_components": [ "P34545", "WBGene00000366", "Q9N3S7", "WBGene00021636", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "P34545", "WBGene00000366", "Q9N3S7", "WBGene00021636", "P34545", "WBGene00000366", "Q9N3S7", "WBGene00021636" ] }, "reaction_10511057": { "compartment": "compartment_5460", "id": "reaction_10511057", "reactome": "R-CEL-169260", "name": "Reducing equivalents from beta-oxidation of fatty acids transfer to ETF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10511052", "species_31649" ], "products": [ "species_10511054", "species_113596" ], "modifiers": [ [ "species_10511052", "catalyst" ] ], "additional_components": [ "Q93615", "WBGene00009187", "Q9TXI4", "WBGene00017734", "species_76577", "species_113596", "species_31649", "Q93615", "WBGene00009187", "Q9TXI4", "WBGene00017734", "species_76577", "Q93615", "WBGene00009187", "Q9TXI4", "WBGene00017734", "species_76577", "species_113596" ] }, "reaction_10511065": { "compartment": "compartment_5460", "id": "reaction_10511065", "reactome": "R-CEL-169270", "name": "ETFDH oxidises ETF (reduced) to ETF, reduces CoQ to QH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73663", "species_10511054" ], "products": [ "species_10511052", "species_76633" ], "modifiers": [ [ "species_10511062", "catalyst" ] ], "additional_components": [ "species_31649", "Q93615", "WBGene00009187", "Q9TXI4", "WBGene00017734", "species_76577", "Q93615", "WBGene00009187", "Q9TXI4", "WBGene00017734", "species_76577", "species_113596", "WBGene00002855" ] }, "reaction_10562852": { "compartment": "compartment_5460", "id": "reaction_10562852", "reactome": "R-CEL-6800868", "name": "NDUF subunits bind to form the IP subcomplex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10561725", "species_10561709", "species_10561720", "species_10561718", "species_10561716" ], "products": [ "species_10561727" ], "modifiers": [], "additional_components": [ "WBGene00020417", "Q93873", "WBGene00001520", "Q09644", "WBGene00014227", "Q22619", "WBGene00020636", "Q94360", "WBGene00012376", "Q9N3H3", "WBGene00021800", "species_113596", "Q9N3H3", "WBGene00021800", "species_113596", "Q94360", "WBGene00012376", "Q22619", "WBGene00020636", "Q93873", "WBGene00001520", "Q09644", "WBGene00014227", "Q86NC2", "WBGene00020417" ] }, "reaction_10561780": { "compartment": "compartment_5460", "id": "reaction_10561780", "reactome": "R-CEL-6799203", "name": "IP subcomplex binds NDUFAF3, NDUFAF4, TIMMDC1 to form Intermediate 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10561742", "species_10561727", "species_10561737", "species_10561732" ], "products": [ "species_10561744" ], "modifiers": [], "additional_components": [ "WBGene00021421", "Q9N3H3", "WBGene00021800", "species_113596", "Q94360", "WBGene00012376", "Q22619", "WBGene00020636", "Q93873", "WBGene00001520", "Q09644", "WBGene00014227", "Q86NC2", "WBGene00020417", "WBGene00007113", "WBGene00011123", "Q93931", "WBGene00011123", "Q17439", "WBGene00007113", "Q9N3H3", "WBGene00021800", "species_113596", "Q94360", "WBGene00012376", "Q22619", "WBGene00020636", "Q93873", "WBGene00001520", "Q09644", "WBGene00014227", "Q86NC2", "WBGene00020417", "I2HAE1", "WBGene00021421" ] }, "reaction_10561748": { "compartment": "compartment_70616", "id": "reaction_10561748", "reactome": "R-CEL-6799178", "name": "Intermediate 1 binds HP subcomplex to form Intermediate 2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10561700", "species_10561744" ], "products": [ "species_10561746" ], "modifiers": [], "additional_components": [ "Q20412", "WBGene00009712", "Q18359", "WBGene00007880", "Q93831", "WBGene00010326", "Q18095", "WBGene00007684", "Q9BL33", "WBGene00022169", "Q9XWG2", "WBGene00013406", "Q23098", "WBGene00012166", "O44955", "WBGene00016393", "H2KYV1", "WBGene00016118", "O18236", "WBGene00013308", "Q9U241", "WBGene00013237", "P90789", "WBGene00008414", "O44509", "WBGene00018361", "O02267", "WBGene00009740", "Q21233", "WBGene00019401", "species_113596", "Q9XWJ5", "WBGene00013094", "Q9BL03", "WBGene00021849", "Q18036", "WBGene00015810", "Q93931", "WBGene00011123", "Q17439", "WBGene00007113", "Q9N3H3", "WBGene00021800", "species_113596", "Q94360", "WBGene00012376", "Q22619", "WBGene00020636", "Q93873", "WBGene00001520", "Q09644", "WBGene00014227", "Q86NC2", "WBGene00020417", "I2HAE1", "WBGene00021421", "Q93931", "WBGene00011123", "Q17439", "WBGene00007113", "Q9N3H3", "WBGene00021800", "species_113596", "Q94360", "WBGene00012376", "Q22619", "WBGene00020636", "Q93873", "WBGene00001520", "Q09644", "WBGene00014227", "Q86NC2", "WBGene00020417", "I2HAE1", "WBGene00021421", "Q20412", "WBGene00009712", "Q18359", "WBGene00007880", "Q93831", "WBGene00010326", "Q18095", "WBGene00007684", "Q9BL33", "WBGene00022169", "Q9XWG2", "WBGene00013406", "Q23098", "WBGene00012166", "O44955", "WBGene00016393", "H2KYV1", "WBGene00016118", "O18236", "WBGene00013308", "Q9U241", "WBGene00013237", "P90789", "WBGene00008414", "O44509", "WBGene00018361", "O02267", "WBGene00009740", "Q21233", "WBGene00019401", "Q9XWJ5", "WBGene00013094", "Q9BL03", "WBGene00021849", "Q18036", "WBGene00015810" ] }, "reaction_10521531": { "compartment": "compartment_7660", "id": "reaction_10521531", "reactome": "R-CEL-400204", "name": "PPARA binds RXRA forming PPARA:RXRA heterodimer at promoter of target gene", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10514477", "species_422139", "species_10519403" ], "products": [ "species_10521529" ], "modifiers": [], "additional_components": [ "WBGene00003681", "P41830", "WBGene00004786", "Q10902", "WBGene00003601", "Q20765", "WBGene00003606", "Q9XUK7", "WBGene00003675", "P41830", "WBGene00004786", "Q10902", "WBGene00003601", "Q20765", "WBGene00003606", "Q9XUK7", "WBGene00003675", "Q9U2R6", "WBGene00003681" ] }, "reaction_10542707": { "compartment": "compartment_70101", "id": "reaction_10542707", "reactome": "R-CEL-2106614", "name": "Duplex miRNA is loaded into Argonaute", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10542705" ], "products": [ "species_10516856" ], "modifiers": [], "additional_components": [ "P34529", "WBGene00000939", "G5EBF5", "WBGene00004326", "G5EES3", "WBGene00000105", "P34529", "WBGene00000939", "G5EES3", "WBGene00000105", "G5EBF5", "WBGene00004326" ] }, "reaction_10516876": { "compartment": "compartment_70101", "id": "reaction_10516876", "reactome": "R-CEL-210805", "name": "Removal of miRNA passenger strand", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10516856" ], "products": [ "species_10516874" ], "modifiers": [], "additional_components": [ "P34529", "WBGene00000939", "G5EES3", "WBGene00000105", "G5EBF5", "WBGene00004326", "P34529", "WBGene00000939", "G5EES3", "WBGene00000105", "G5EBF5", "WBGene00004326" ] }, "reaction_10567937": { "compartment": "compartment_70101", "id": "reaction_10567937", "reactome": "R-CEL-8931974", "name": "N6AMT2 transfers 3xCH3 from 3xAdoMet to EEF1A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71284", "species_10509904" ], "products": [ "species_10567929", "species_71285" ], "modifiers": [ [ "species_10567934", "catalyst" ] ], "additional_components": [ "WBGene00001168", "WBGene00001168", "WBGene00043057" ] }, "reaction_10568005": { "compartment": "compartment_70101", "id": "reaction_10568005", "reactome": "R-CEL-8932413", "name": "METTL10 transfers 3xCH3 from 3xAdoMet to EEF1A1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71284", "species_10509904" ], "products": [ "species_10567997", "species_71285" ], "modifiers": [ [ "species_10568002", "catalyst" ] ], "additional_components": [ "WBGene00001168", "WBGene00001168", "WBGene00017919" ] }, "reaction_10567926": { "compartment": "compartment_5460", "id": "reaction_10567926", "reactome": "R-CEL-8931858", "name": "ETFBKMT transfers 3xCH3 from 3xAdoMet to ETFB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10511050", "species_2162265" ], "products": [ "species_10567918", "species_2162252" ], "modifiers": [ [ "species_10567923", "catalyst" ] ], "additional_components": [ "WBGene00017734", "WBGene00017734", "WBGene00016492" ] }, "reaction_10567962": { "compartment": "compartment_70101", "id": "reaction_10567962", "reactome": "R-CEL-8932276", "name": "VCPKMT (METTL21D) transfers 3xCH3 from 3xAdoMet to VCP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71284", "species_10551284" ], "products": [ "species_71285", "species_10567954" ], "modifiers": [ [ "species_10567959", "catalyst" ] ], "additional_components": [ "WBGene00008053", "WBGene00008053", "WBGene00016591" ] }, "reaction_10523164": { "compartment": "compartment_876", "id": "reaction_10523164", "reactome": "R-CEL-428510", "name": "ROBO3.1 antagonizes ROBO1/ROBO2 to allow floor plate crossing", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10523160", "species_10523158" ], "products": [ "species_10523162" ], "modifiers": [], "additional_components": [ "WBGene00004732", "H2KZ60", "WBGene00016354", "Q18806", "WBGene00004370", "H2KZ60", "WBGene00016354", "Q18806", "WBGene00004370", "Q53U87", "WBGene00004732" ] }, "reaction_10568768": { "compartment": "compartment_17957", "id": "reaction_10568768", "reactome": "R-CEL-8944257", "name": "Association of procollagen type XXIV", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10539093" ], "products": [ "species_10540952" ], "modifiers": [], "additional_components": [ "WBGene00000659", "Q21437", "WBGene00000659" ] }, "reaction_10568770": { "compartment": "compartment_17957", "id": "reaction_10568770", "reactome": "R-CEL-8944261", "name": "Association of procollagen type XIII", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10540942" ], "products": [ "species_10540944" ], "modifiers": [], "additional_components": [ "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689", "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689" ] }, "reaction_10568772": { "compartment": "compartment_17957", "id": "reaction_10568772", "reactome": "R-CEL-8944262", "name": "Association of procollagen type X", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10540932" ], "products": [ "species_10540934" ], "modifiers": [], "additional_components": [ "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689", "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689" ] }, "reaction_10568774": { "compartment": "compartment_17957", "id": "reaction_10568774", "reactome": "R-CEL-8944263", "name": "Association of procollagen type II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10540908" ], "products": [ "species_10540910" ], "modifiers": [], "additional_components": [ "O76368", "WBGene00000674", "Q09457", "WBGene00000251", "Q9N4U2", "WBGene00000647", "O76368", "WBGene00000674", "Q09457", "WBGene00000251", "Q9N4U2", "WBGene00000647" ] }, "reaction_10539495": { "compartment": "compartment_17957", "id": "reaction_10539495", "reactome": "R-CEL-2002401", "name": "Association of procollagen type XVIII", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10539097" ], "products": [ "species_10539493" ], "modifiers": [], "additional_components": [ "WBGene00000659", "Q21437", "WBGene00000659" ] }, "reaction_10568776": { "compartment": "compartment_17957", "id": "reaction_10568776", "reactome": "R-CEL-8944266", "name": "Association of procollagen type XI", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10540908", "species_10540938", "species_10540936" ], "products": [ "species_10540940" ], "modifiers": [], "additional_components": [ "O76368", "WBGene00000674", "Q09457", "WBGene00000251", "Q9N4U2", "WBGene00000647", "Q9N3X9", "WBGene00000689", "O17641", "WBGene00000751", "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689", "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689", "O76368", "WBGene00000674", "Q09457", "WBGene00000251", "Q9N4U2", "WBGene00000647" ] }, "reaction_10568754": { "compartment": "compartment_17957", "id": "reaction_10568754", "reactome": "R-CEL-8944214", "name": "Association of procollagen type I", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10536687", "species_10539099" ], "products": [ "species_10540906" ], "modifiers": [], "additional_components": [ "WBGene00000647", "WBGene00000647", "Q9N4U2", "WBGene00000647" ] }, "reaction_10568756": { "compartment": "compartment_17957", "id": "reaction_10568756", "reactome": "R-CEL-8944218", "name": "Association of procollagen type VIII", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10539063", "species_10540928" ], "products": [ "species_10540930" ], "modifiers": [], "additional_components": [ "WBGene00000751", "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689", "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689" ] }, "reaction_10568758": { "compartment": "compartment_17957", "id": "reaction_10568758", "reactome": "R-CEL-8944223", "name": "Association of procollagen type V", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10540920", "species_10539061", "species_10540916" ], "products": [ "species_10540926" ], "modifiers": [], "additional_components": [ "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689", "WBGene00002280", "O76368", "WBGene00000674", "Q09457", "WBGene00000251", "Q9N4U2", "WBGene00000647", "O76368", "WBGene00000674", "Q09457", "WBGene00000251", "Q9N4U2", "WBGene00000647", "P17140", "WBGene00002280", "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689" ] }, "reaction_10568762": { "compartment": "compartment_17957", "id": "reaction_10568762", "reactome": "R-CEL-8944233", "name": "Association of procollagen type XIX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10540948" ], "products": [ "species_10540950" ], "modifiers": [], "additional_components": [ "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689", "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689" ] }, "reaction_10568764": { "compartment": "compartment_17957", "id": "reaction_10568764", "reactome": "R-CEL-8944240", "name": "Association of procollagen type III", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10540912" ], "products": [ "species_10540914" ], "modifiers": [], "additional_components": [ "Q9N4U2", "WBGene00000647", "O76368", "WBGene00000674", "Q09457", "WBGene00000251", "Q9N4U2", "WBGene00000647", "O76368", "WBGene00000674", "Q09457", "WBGene00000251" ] }, "reaction_10568766": { "compartment": "compartment_17957", "id": "reaction_10568766", "reactome": "R-CEL-8944242", "name": "Association of procollagen type XXVII", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10539095" ], "products": [ "species_10540954" ], "modifiers": [], "additional_components": [ "WBGene00002280", "P17140", "WBGene00002280" ] }, "reaction_10512308": { "compartment": "compartment_70101", "id": "reaction_10512308", "reactome": "R-CEL-183058", "name": "Phosphorylation of CBL (EGFR:GRB2:CBL)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10512305" ], "products": [ "species_29370", "species_10512272" ], "modifiers": [ [ "species_10512305", "catalyst" ] ], "additional_components": [ "P24348", "WBGene00002299", "P29355", "WBGene00004774", "Q19019", "WBGene00004829", "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "P29355", "WBGene00004774", "P24348", "WBGene00002299", "P29355", "WBGene00004774", "Q19019", "WBGene00004829" ] }, "reaction_10566342": { "compartment": "compartment_876", "id": "reaction_10566342", "reactome": "R-CEL-8867041", "name": "EGFR phosphorylates EPS15", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10566337" ], "products": [ "species_29370", "species_10566339" ], "modifiers": [ [ "species_10566337", "catalyst" ] ], "additional_components": [ "Q9BIF4", "WBGene00001224", "species_179856", "Q18453", "WBGene00004682", "Q9BI71", "WBGene00001329", "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "B1V8A0", "WBGene00006791", "P29355", "WBGene00004774", "Q17796", "WBGene00004101", "O01498", "WBGene00004109", "Q9BIF4", "WBGene00001224", "species_179856", "Q17796", "WBGene00004101", "O01498", "WBGene00004109", "Q18453", "WBGene00004682", "Q9BI71", "WBGene00001329", "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "B1V8A0", "WBGene00006791", "P29355", "WBGene00004774", "Q9BIF4", "WBGene00001224", "species_179856", "Q18453", "WBGene00004682", "Q9BI71", "WBGene00001329", "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "B1V8A0", "WBGene00006791", "P29355", "WBGene00004774", "Q17796", "WBGene00004101", "O01498", "WBGene00004109" ] }, "reaction_10512298": { "compartment": "compartment_70101", "id": "reaction_10512298", "reactome": "R-CEL-183036", "name": "Ubiquitination of stimulated EGFR (CBL:GRB2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502375", "species_10512272" ], "products": [ "species_10512290" ], "modifiers": [ [ "species_10512272", "catalyst" ], [ "species_10512296", "inhibitor" ] ], "additional_components": [ "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "P29355", "WBGene00004774", "P29355", "WBGene00004774", "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "P29355", "WBGene00004774", "WBGene00011755" ] }, "reaction_10512315": { "compartment": "compartment_70101", "id": "reaction_10512315", "reactome": "R-CEL-183084", "name": "CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502375", "species_10512310" ], "products": [ "species_10512312", "species_10512305" ], "modifiers": [ [ "species_10512310", "catalyst" ] ], "additional_components": [ "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "P29355", "WBGene00004774", "Q05062", "WBGene00000390", "species_29438", "Q21430", "WBGene00010776", "Q05062", "WBGene00000390", "species_29438", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "Q21430", "WBGene00010776", "P24348", "WBGene00002299", "P29355", "WBGene00004774", "Q19019", "WBGene00004829", "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "P29355", "WBGene00004774", "Q05062", "WBGene00000390", "species_29438", "Q21430", "WBGene00010776" ] }, "reaction_10512270": { "compartment": "compartment_70101", "id": "reaction_10512270", "reactome": "R-CEL-182986", "name": "CBL-mediated ubiquitination of CIN85", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10512255", "species_10502375" ], "products": [ "species_10512265" ], "modifiers": [ [ "species_10512255", "catalyst" ] ], "additional_components": [ "Q9BIF4", "WBGene00001224", "B1V8A0", "WBGene00006791", "Q18453", "WBGene00004682", "Q9BI71", "WBGene00001329", "P24348", "WBGene00002299", "Q19019", "WBGene00004829", "Q17796", "WBGene00004101", "O01498", "WBGene00004109", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "Q9BIF4", "WBGene00001224", "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "B1V8A0", "WBGene00006791", "Q18453", "WBGene00004682", "Q9BI71", "WBGene00001329", "Q17796", "WBGene00004101", "O01498", "WBGene00004109", "Q9BIF4", "WBGene00001224", "B1V8A0", "WBGene00006791", "Q18453", "WBGene00004682", "Q9BI71", "WBGene00001329", "P24348", "WBGene00002299", "Q19019", "WBGene00004829", "Q17796", "WBGene00004101", "O01498", "WBGene00004109" ] }, "reaction_10512303": { "compartment": "compartment_70101", "id": "reaction_10512303", "reactome": "R-CEL-183052", "name": "CBL binds to GRB2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10512267", "species_10506871" ], "products": [ "species_10512301" ], "modifiers": [], "additional_components": [ "WBGene00004829", "WBGene00004774", "P29355", "WBGene00004774", "Q19019", "WBGene00004829" ] }, "reaction_10512319": { "compartment": "compartment_70101", "id": "reaction_10512319", "reactome": "R-CEL-183094", "name": "CDC42:GTP binds CBL:Beta-Pix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10512286", "species_10512267" ], "products": [ "species_10512317" ], "modifiers": [], "additional_components": [ "Q05062", "WBGene00000390", "species_29438", "Q21430", "WBGene00010776", "WBGene00004829", "Q19019", "WBGene00004829", "Q05062", "WBGene00000390", "species_29438", "Q21430", "WBGene00010776" ] }, "reaction_10566350": { "compartment": "compartment_876", "id": "reaction_10566350", "reactome": "R-CEL-8867047", "name": "PTPN3 dephosphorylates EPS15", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10566339" ], "products": [ "species_29372", "species_10566337" ], "modifiers": [ [ "species_10566347", "catalyst" ] ], "additional_components": [ "Q9BIF4", "WBGene00001224", "species_179856", "Q17796", "WBGene00004101", "O01498", "WBGene00004109", "Q18453", "WBGene00004682", "Q9BI71", "WBGene00001329", "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "B1V8A0", "WBGene00006791", "P29355", "WBGene00004774", "Q9BIF4", "WBGene00001224", "species_179856", "Q18453", "WBGene00004682", "Q9BI71", "WBGene00001329", "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "B1V8A0", "WBGene00006791", "P29355", "WBGene00004774", "Q17796", "WBGene00004101", "O01498", "WBGene00004109", "WBGene00004213" ] }, "reaction_10541063": { "compartment": "compartment_984", "id": "reaction_10541063", "reactome": "R-CEL-2022381", "name": "Cathepsin Z (Cathepsin X) hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_10541036" ], "products": [ "species_10528011" ], "modifiers": [ [ "species_10541060", "catalyst" ] ], "additional_components": [ "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "A9Z1L1", "WBGene00005648", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "A9Z1L1", "WBGene00005648", "G5ECY2", "WBGene00005644", "Q9XWA4", "WBGene00013764", "Q9XXQ7", "WBGene00013764", "G5EGP8", "WBGene00000788", "P92005", "WBGene00000789", "Q18740", "WBGene00008231", "Q9U2X1", "WBGene00013764" ] }, "reaction_10541193": { "compartment": "compartment_984", "id": "reaction_10541193", "reactome": "R-CEL-2022403", "name": "Renin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10541102", "species_109276" ], "products": [ "species_10541036" ], "modifiers": [ [ "species_10541190", "catalyst" ], [ "species_10541190", "catalyst" ], [ "species_2022362", "inhibitor" ] ], "additional_components": [ "A9Z1L1", "WBGene00005648", "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "A9Z1L1", "WBGene00005648", "Q9XTY9", "WBGene00010993", "Q21966", "WBGene00000217", "O01530", "WBGene00000219", "Q22972", "WBGene00017881", "O01531", "WBGene00017678", "Q7JKL9", "WBGene00013973", "O01532", "WBGene00000218", "Q86NE0", "WBGene00000215", "O45072", "WBGene00015700", "Q8MYN5", "WBGene00012683", "P55956", "WBGene00000216", "G5EC01", "WBGene00077655", "Q8MYN6", "WBGene00012682", "Q18020", "WBGene00007605", "G5EEI4", "WBGene00000214", "Q8MYN7", "WBGene00012681", "Q9XTY9", "WBGene00010993", "Q21966", "WBGene00000217", "O01530", "WBGene00000219", "Q22972", "WBGene00017881", "O01531", "WBGene00017678", "Q7JKL9", "WBGene00013973", "O01532", "WBGene00000218", "Q86NE0", "WBGene00000215", "O45072", "WBGene00015700", "Q8MYN5", "WBGene00012683", "P55956", "WBGene00000216", "G5EC01", "WBGene00077655", "Q8MYN6", "WBGene00012682", "Q18020", "WBGene00007605", "G5EEI4", "WBGene00000214", "Q8MYN7", "WBGene00012681" ] }, "reaction_10541065": { "compartment": "compartment_984", "id": "reaction_10541065", "reactome": "R-CEL-2022396", "name": "Neprilysin hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-7)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_10541036" ], "products": [ "species_10541012" ], "modifiers": [ [ "species_10541017", "catalyst" ] ], "additional_components": [ "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "A9Z1L1", "WBGene00005648", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "A9Z1L1", "WBGene00005648", "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "WBGene00013926" ] }, "reaction_10541930": { "compartment": "compartment_984", "id": "reaction_10541930", "reactome": "R-CEL-2028294", "name": "Mast Cell Carboxypeptidase hydrolyzes Angiotensin-(1-10) to Yield Angiotensin-(1-9)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_10541036" ], "products": [ "species_10540996" ], "modifiers": [ [ "species_10541927", "catalyst" ] ], "additional_components": [ "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "A9Z1L1", "WBGene00005648", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "A9Z1L1", "WBGene00005648", "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q9BL88", "WBGene00021984", "H2L0D7", "WBGene00021984", "G3MU29", "WBGene00021984", "Q9TZC6", "WBGene00021984", "H2L0K5", "WBGene00021984", "G5EC13", "WBGene00021984", "Q9XU75", "WBGene00011235", "Q6A577", "WBGene00021984", "G5EC96", "WBGene00021984" ] }, "reaction_10541196": { "compartment": "compartment_984", "id": "reaction_10541196", "reactome": "R-CEL-2022405", "name": "ACE hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_10541036" ], "products": [ "species_10528011" ], "modifiers": [ [ "species_10541067", "catalyst" ], [ "species_188972", "catalyst" ] ], "additional_components": [ "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "A9Z1L1", "WBGene00005648", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "A9Z1L1", "WBGene00005648", "G5ECY2", "WBGene00005644", "WBGene00000039" ] }, "reaction_10572173": { "compartment": "compartment_984", "id": "reaction_10572173", "reactome": "R-CEL-9614933", "name": "ACEIs bind ACE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9614913", "species_10542353" ], "products": [ "species_10542356" ], "modifiers": [], "additional_components": [ "WBGene00000039", "Q18581", "WBGene00000039" ] }, "reaction_10541070": { "compartment": "compartment_984", "id": "reaction_10541070", "reactome": "R-CEL-2022398", "name": "ACE hydrolyzes Angiotensin-(1-9) to Angiotensin-(1-7)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_10540996" ], "products": [ "species_10541012" ], "modifiers": [ [ "species_10541067", "catalyst" ] ], "additional_components": [ "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "A9Z1L1", "WBGene00005648", "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "A9Z1L1", "WBGene00005648", "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "WBGene00000039" ] }, "reaction_10541235": { "compartment": "compartment_984", "id": "reaction_10541235", "reactome": "R-CEL-2022412", "name": "Renin hydrolyzes Angiotensinogen to Angiotensin-(1-10)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10541102", "species_109276" ], "products": [ "species_10541036" ], "modifiers": [ [ "species_10541232", "catalyst" ], [ "species_2022362", "inhibitor" ] ], "additional_components": [ "A9Z1L1", "WBGene00005648", "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "A9Z1L1", "WBGene00005648", "Q22972", "WBGene00017881", "Q7JKL9", "WBGene00013973", "Q86NE0", "WBGene00000215", "Q8MYN5", "WBGene00012683", "Q8MYN6", "WBGene00012682", "Q8MYN7", "WBGene00012681", "G5EC01", "WBGene00077655", "G5EEI4", "WBGene00000214", "O01530", "WBGene00000219", "O01531", "WBGene00017678", "O01532", "WBGene00000218", "O45072", "WBGene00015700", "P55956", "WBGene00000216", "Q18020", "WBGene00007605", "Q21966", "WBGene00000217" ] }, "reaction_10541044": { "compartment": "compartment_984", "id": "reaction_10541044", "reactome": "R-CEL-2022378", "name": "ACE2 hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-9)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_10541036" ], "products": [ "species_10540996" ], "modifiers": [ [ "species_10541041", "catalyst" ] ], "additional_components": [ "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "A9Z1L1", "WBGene00005648", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "A9Z1L1", "WBGene00005648", "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "WBGene00000039" ] }, "reaction_10542358": { "compartment": "compartment_984", "id": "reaction_10542358", "reactome": "R-CEL-2065355", "name": "Secreted ACE hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_10541036" ], "products": [ "species_10528011" ], "modifiers": [ [ "species_10542353", "catalyst" ], [ "species_188972", "catalyst" ], [ "species_10542356", "inhibitor" ] ], "additional_components": [ "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "A9Z1L1", "WBGene00005648", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "A9Z1L1", "WBGene00005648", "G5ECY2", "WBGene00005644", "WBGene00000039", "Q18581", "WBGene00000039" ] }, "reaction_10541046": { "compartment": "compartment_984", "id": "reaction_10541046", "reactome": "R-CEL-2022379", "name": "ACE2 hydrolyzes Angiotensin-(1-8) to Angiotensin-(1-7)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_10528011" ], "products": [ "species_10541012" ], "modifiers": [ [ "species_10541041", "catalyst" ] ], "additional_components": [ "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "A9Z1L1", "WBGene00005648", "G5ECY2", "WBGene00005644", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "A9Z1L1", "WBGene00005648", "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "WBGene00000039" ] }, "reaction_10572216": { "compartment": "compartment_984", "id": "reaction_10572216", "reactome": "R-CEL-9619024", "name": "CES1trimer hydrolyses ACEI pro-drugs to ACEIs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113519", "species_9619052" ], "products": [ "species_8878776", "species_9619021" ], "modifiers": [ [ "species_10557032", "catalyst" ] ], "additional_components": [ "Q04457", "WBGene00001578" ] }, "reaction_10542396": { "compartment": "compartment_984", "id": "reaction_10542396", "reactome": "R-CEL-2065357", "name": "Prorenin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10541102", "species_109276" ], "products": [ "species_10541036" ], "modifiers": [ [ "species_10542393", "catalyst" ], [ "species_2022362", "inhibitor" ] ], "additional_components": [ "A9Z1L1", "WBGene00005648", "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "A9Z1L1", "WBGene00005648", "Q9XTY9", "WBGene00010993", "O01532", "WBGene00000218", "O45072", "WBGene00015700", "P55956", "WBGene00000216", "Q18020", "WBGene00007605", "Q21966", "WBGene00000217", "Q22972", "WBGene00017881", "Q7JKL9", "WBGene00013973", "Q86NE0", "WBGene00000215", "Q8MYN5", "WBGene00012683", "Q8MYN6", "WBGene00012682", "Q8MYN7", "WBGene00012681", "G5EC01", "WBGene00077655", "G5EEI4", "WBGene00000214", "O01530", "WBGene00000219", "O01531", "WBGene00017678" ] }, "reaction_10541020": { "compartment": "compartment_984", "id": "reaction_10541020", "reactome": "R-CEL-2022368", "name": "Neprilysin hydrolyzes Angiotensin-(1-9) to Angiotensin-(1-7)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_10540996" ], "products": [ "species_10541012" ], "modifiers": [ [ "species_10541017", "catalyst" ] ], "additional_components": [ "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "A9Z1L1", "WBGene00005648", "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "A9Z1L1", "WBGene00005648", "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "WBGene00013926" ] }, "reaction_10549712": { "compartment": "compartment_7660", "id": "reaction_10549712", "reactome": "R-CEL-4755494", "name": "PIAS1,2-1 SUMOylate NR5A2 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10549685", "species_10546081" ], "products": [ "species_10549707", "species_10546073" ], "modifiers": [ [ "species_10549709", "catalyst" ] ], "additional_components": [ "CHEBI:77361", "Q9N2W3", "WBGene00022374", "Q18190", "WBGene00016126", "Q9XTJ4", "WBGene00003602", "Q19345", "WBGene00003623", "Q21104", "WBGene00003629", "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "CHEBI:77361", "P55853", "WBGene00004888", "Q21104", "WBGene00003629", "Q9N2W3", "WBGene00022374", "Q9XTJ4", "WBGene00003602", "Q18190", "WBGene00016126", "Q19345", "WBGene00003623", "WBGene00006706", "Q21970", "WBGene00011259", "Q94361", "WBGene00001574" ] }, "reaction_10549218": { "compartment": "compartment_7660", "id": "reaction_10549218", "reactome": "R-CEL-4546386", "name": "PIAS1,3 SUMOylates NR5A1 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546081", "species_10519472" ], "products": [ "species_10549213", "species_10546073" ], "modifiers": [ [ "species_10549215", "catalyst" ] ], "additional_components": [ "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "WBGene00003623", "P55853", "WBGene00004888", "Q19345", "WBGene00003623", "WBGene00006706", "Q21970", "WBGene00011259", "Q94361", "WBGene00001574" ] }, "reaction_10549683": { "compartment": "compartment_7660", "id": "reaction_10549683", "reactome": "R-CEL-4755419", "name": "SUMOylation of NR1H4 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10549672", "species_10546081" ], "products": [ "species_10546073", "species_10549681" ], "modifiers": [], "additional_components": [ "G5ECR9", "WBGene00006790", "CHEBI:16755", "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "WBGene00006706", "CHEBI:16755", "P55853", "WBGene00004888", "G5ECR9", "WBGene00006790" ] }, "reaction_10549573": { "compartment": "compartment_7660", "id": "reaction_10549573", "reactome": "R-CEL-4719447", "name": "PIAS2-2 SUMOylates THRA with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546081", "species_10519457" ], "products": [ "species_10546073", "species_10549571" ], "modifiers": [ [ "species_10548942", "catalyst" ] ], "additional_components": [ "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "P41830", "WBGene00004786", "Q10902", "WBGene00003601", "Q20765", "WBGene00003606", "Q9XUK7", "WBGene00003675", "WBGene00006706", "P41830", "WBGene00004786", "Q10902", "WBGene00003601", "Q20765", "WBGene00003606", "Q9XUK7", "WBGene00003675", "P55853", "WBGene00004888", "WBGene00001574" ] }, "reaction_10549096": { "compartment": "compartment_7660", "id": "reaction_10549096", "reactome": "R-CEL-4341048", "name": "SUMOylation of RXRA with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10514477", "species_10546081" ], "products": [ "species_10546073", "species_10549094" ], "modifiers": [ [ "species_10546081", "catalyst" ] ], "additional_components": [ "WBGene00003681", "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "WBGene00006706", "P55853", "WBGene00004888", "Q9U2R6", "WBGene00003681", "Q95017", "WBGene00006706", "P55853", "WBGene00004888" ] }, "reaction_10549548": { "compartment": "compartment_7660", "id": "reaction_10549548", "reactome": "R-CEL-4719436", "name": "PIAS2,3,4 SUMOylate RORA with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10519389", "species_10546081" ], "products": [ "species_10546073", "species_10549543" ], "modifiers": [ [ "species_10549545", "catalyst" ] ], "additional_components": [ "WBGene00003622", "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "WBGene00006706", "P41828", "WBGene00003622", "P55853", "WBGene00004888", "Q21970", "WBGene00011259", "Q94361", "WBGene00001574" ] }, "reaction_10549117": { "compartment": "compartment_7660", "id": "reaction_10549117", "reactome": "R-CEL-4341070", "name": "PIAS4 SUMOylates PPARA with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10519403", "species_10546081" ], "products": [ "species_10549115", "species_10546073" ], "modifiers": [ [ "species_10546168", "catalyst" ] ], "additional_components": [ "P41830", "WBGene00004786", "Q10902", "WBGene00003601", "Q20765", "WBGene00003606", "Q9XUK7", "WBGene00003675", "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "Q10902", "WBGene00003601", "Q20765", "WBGene00003606", "Q9XUK7", "WBGene00003675", "P41830", "WBGene00004786", "P55853", "WBGene00004888", "WBGene00006706", "Q21970", "WBGene00011259", "Q94361", "WBGene00001574" ] }, "reaction_10549535": { "compartment": "compartment_7660", "id": "reaction_10549535", "reactome": "R-CEL-4719424", "name": "PIAS1 SUMOylates THRB with SUMO1.", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10519467", "species_10546081" ], "products": [ "species_10549533", "species_10546073" ], "modifiers": [ [ "species_10528091", "catalyst" ] ], "additional_components": [ "P41830", "WBGene00004786", "Q10902", "WBGene00003601", "Q20765", "WBGene00003606", "Q9XUK7", "WBGene00003675", "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "P55853", "WBGene00004888", "Q20765", "WBGene00003606", "Q9XUK7", "WBGene00003675", "P41830", "WBGene00004786", "Q10902", "WBGene00003601", "WBGene00006706", "Q21970", "WBGene00011259", "Q94361", "WBGene00001574" ] }, "reaction_10554195": { "compartment": "compartment_7660", "id": "reaction_10554195", "reactome": "R-CEL-5649856", "name": "Oxidative damage to the AP site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508796" ], "products": [ "species_10554193" ], "modifiers": [], "additional_components": [ "G5EBR7", "WBGene00001372", "G5EBR7", "WBGene00001372" ] }, "reaction_10508799": { "compartment": "compartment_7660", "id": "reaction_10508799", "reactome": "R-CEL-110359", "name": "APEX1 mediates endonucleolytic cleavage at the 5' side of the AP site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508788" ], "products": [ "species_10508796" ], "modifiers": [ [ "species_10508788", "catalyst" ] ], "additional_components": [ "G5EBR7", "WBGene00001372", "G5EBR7", "WBGene00001372", "G5EBR7", "WBGene00001372" ] }, "reaction_10508673": { "compartment": "compartment_7660", "id": "reaction_10508673", "reactome": "R-CEL-110215", "name": "Cleavage of uracil by UNG glycosylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508666" ], "products": [ "species_10508670", "species_29554" ], "modifiers": [ [ "species_10508666", "catalyst" ] ], "additional_components": [ "Q9U221", "WBGene00013241", "Q9U221", "WBGene00013241", "Q9U221", "WBGene00013241" ] }, "reaction_10508689": { "compartment": "compartment_7660", "id": "reaction_10508689", "reactome": "R-CEL-110224", "name": "Cleavage of thymine glycol by NTHL1 glycosylase ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508684" ], "products": [ "species_10508686", "species_110223" ], "modifiers": [ [ "species_10508684", "catalyst" ] ], "additional_components": [ "P54137", "WBGene00011201", "P54137", "WBGene00011201", "P54137", "WBGene00011201" ] }, "reaction_10508710": { "compartment": "compartment_7660", "id": "reaction_10508710", "reactome": "R-CEL-110229", "name": "Cleavage of formamidopyrimidine (FapyA) by NTHL1 glycosylase ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508707" ], "products": [ "species_10508686", "species_5637659" ], "modifiers": [ [ "species_10508707", "catalyst" ] ], "additional_components": [ "P54137", "WBGene00011201", "P54137", "WBGene00011201", "P54137", "WBGene00011201" ] }, "reaction_10508680": { "compartment": "compartment_7660", "id": "reaction_10508680", "reactome": "R-CEL-110217", "name": "Cleavage of 5-hydroxyluracil by UNG glycosylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508677" ], "products": [ "species_10508670", "species_110216" ], "modifiers": [ [ "species_10508677", "catalyst" ] ], "additional_components": [ "Q9U221", "WBGene00013241", "Q9U221", "WBGene00013241", "Q9U221", "WBGene00013241" ] }, "reaction_10508696": { "compartment": "compartment_7660", "id": "reaction_10508696", "reactome": "R-CEL-110226", "name": "Cleavage of cytosine glycol by NTHL1 glycosylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508693" ], "products": [ "species_10508686", "species_110225" ], "modifiers": [ [ "species_10508693", "catalyst" ] ], "additional_components": [ "P54137", "WBGene00011201", "P54137", "WBGene00011201", "P54137", "WBGene00011201" ] }, "reaction_10508703": { "compartment": "compartment_7660", "id": "reaction_10508703", "reactome": "R-CEL-110227", "name": "Cleavage of dihydrouracil by NTHL1 glycosylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508700" ], "products": [ "species_10508686", "species_30140" ], "modifiers": [ [ "species_10508700", "catalyst" ] ], "additional_components": [ "P54137", "WBGene00011201", "P54137", "WBGene00011201", "P54137", "WBGene00011201" ] }, "reaction_10507554": { "compartment": "compartment_70101", "id": "reaction_10507554", "reactome": "R-CEL-75887", "name": "Conversion of Glycerol to Glycerol-3-phosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_76116" ], "products": [ "species_29370", "species_76114" ], "modifiers": [ [ "species_10507551", "catalyst" ] ], "additional_components": [ "Q21944", "WBGene00020007" ] }, "reaction_10507603": { "compartment": "compartment_70101", "id": "reaction_10507603", "reactome": "R-CEL-75900", "name": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_75967", "species_76103" ], "products": [ "species_549167", "species_76194" ], "modifiers": [ [ "species_10507600", "catalyst" ] ], "additional_components": [ "Q9NCE1", "WBGene00010408" ] }, "reaction_10557589": { "compartment": "compartment_12045", "id": "reaction_10557589", "reactome": "R-CEL-5696119", "name": "AGMO cleaves alkylglycerol into fatty aldehyde and glycerol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29870", "species_5696122", "species_29368" ], "products": [ "species_29356", "species_1497857", "species_76116", "species_5696116" ], "modifiers": [ [ "species_10557586", "catalyst" ] ], "additional_components": [ "WBGene00007210" ] }, "reaction_10507542": { "compartment": "compartment_70101", "id": "reaction_10507542", "reactome": "R-CEL-75886", "name": "glycerol 3-phosphate + acyl-CoA => 1-acylglycerol 3-phosphate + CoASH [mitochondrial membrane-associated]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_75967", "species_76114" ], "products": [ "species_76194", "species_76112" ], "modifiers": [ [ "species_10507537", "catalyst" ] ], "additional_components": [ "WBGene00017261" ] }, "reaction_10527368": { "compartment": "compartment_70101", "id": "reaction_10527368", "reactome": "R-CEL-549192", "name": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_75967", "species_76103" ], "products": [ "species_549167", "species_76194" ], "modifiers": [ [ "species_10527365", "catalyst" ] ], "additional_components": [ "Q9XUW0", "WBGene00010296", "O01881", "WBGene00021818", "Q23067", "WBGene00020910", "Q9N4S3", "WBGene00021818" ] }, "reaction_10507593": { "compartment": "compartment_70101", "id": "reaction_10507593", "reactome": "R-CEL-75899", "name": "1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76108", "species_29356" ], "products": [ "species_29372", "species_76103" ], "modifiers": [ [ "species_10507586", "catalyst" ] ], "additional_components": [ "WBGene00010425" ] }, "reaction_10562170": { "compartment": "compartment_12045", "id": "reaction_10562170", "reactome": "R-CEL-6800334", "name": "MOGAT1,2,3 transfer acyl group from acyl-CoA to 2-acylglycerol to form DAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6800352", "species_1500578" ], "products": [ "species_76103", "species_76194" ], "modifiers": [ [ "species_10562167", "catalyst" ] ], "additional_components": [ "Q9N4S3", "WBGene00021818", "Q9XUW0", "WBGene00010296", "O01881", "WBGene00021818", "Q23067", "WBGene00020910" ] }, "reaction_10523735": { "compartment": "compartment_70101", "id": "reaction_10523735", "reactome": "R-CEL-430311", "name": "Rsu-1 interacts with Pinch1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10523726", "species_10523731" ], "products": [ "species_10523733" ], "modifiers": [], "additional_components": [ "WBGene00007924", "WBGene00006826", "P50464", "WBGene00006826", "Q09497", "WBGene00007924" ] }, "reaction_10524057": { "compartment": "compartment_70101", "id": "reaction_10524057", "reactome": "R-CEL-432946", "name": "PARVB/Affixin interacts with alpha PIX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10516119", "species_10523717" ], "products": [ "species_10524055" ], "modifiers": [], "additional_components": [ "WBGene00010776", "WBGene00003932", "O16785", "WBGene00003932", "Q21430", "WBGene00010776" ] }, "reaction_10523721": { "compartment": "compartment_70101", "id": "reaction_10523721", "reactome": "R-CEL-430308", "name": "PARVB interacts with Alpha-actinin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10523717", "species_10523712" ], "products": [ "species_10523719" ], "modifiers": [], "additional_components": [ "WBGene00003932", "WBGene00000228", "Q23158", "WBGene00000228", "O16785", "WBGene00003932" ] }, "reaction_10512192": { "compartment": "compartment_70101", "id": "reaction_10512192", "reactome": "R-CEL-179467", "name": "GAB1 binds phosphatidylinositol-3,4,5-trisphosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179838", "species_10512121" ], "products": [ "species_10512159" ], "modifiers": [], "additional_components": [ "P29355", "WBGene00004774", "G5EDJ4", "WBGene00004928", "P29355", "WBGene00004774", "G5EDJ4", "WBGene00004928", "species_179838" ] }, "reaction_10512183": { "compartment": "compartment_70101", "id": "reaction_10512183", "reactome": "R-CEL-177939", "name": "PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10512155", "catalyst" ] ], "additional_components": [ "P24348", "WBGene00002299", "G5EDJ4", "WBGene00004928", "P29355", "WBGene00004774", "species_179838", "G5EDP9", "WBGene00000001", "Q94125", "WBGene00000090" ] }, "reaction_10512169": { "compartment": "compartment_70101", "id": "reaction_10512169", "reactome": "R-CEL-177930", "name": "GAB1 phosphorylation by EGFR kinase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10512163" ], "products": [ "species_29370", "species_10512153" ], "modifiers": [ [ "species_10512163", "catalyst" ] ], "additional_components": [ "P29355", "WBGene00004774", "G5EDJ4", "WBGene00004928", "species_179838", "P24348", "WBGene00002299", "P24348", "WBGene00002299", "G5EDJ4", "WBGene00004928", "P29355", "WBGene00004774", "species_179838", "P29355", "WBGene00004774", "G5EDJ4", "WBGene00004928", "species_179838", "P24348", "WBGene00002299" ] }, "reaction_10512123": { "compartment": "compartment_70101", "id": "reaction_10512123", "reactome": "R-CEL-177920", "name": "Binding of GRB2 to GAB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10506871", "species_10512119" ], "products": [ "species_10512121" ], "modifiers": [], "additional_components": [ "WBGene00004774", "WBGene00004928", "P29355", "WBGene00004774", "G5EDJ4", "WBGene00004928" ] }, "reaction_10512157": { "compartment": "compartment_876", "id": "reaction_10512157", "reactome": "R-CEL-177927", "name": "PI3K binds to EGF:EGFR:GRB2:GAB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10506892", "species_10512153" ], "products": [ "species_10512155" ], "modifiers": [], "additional_components": [ "G5EDP9", "WBGene00000001", "Q94125", "WBGene00000090", "P24348", "WBGene00002299", "G5EDJ4", "WBGene00004928", "P29355", "WBGene00004774", "species_179838", "P24348", "WBGene00002299", "G5EDJ4", "WBGene00004928", "P29355", "WBGene00004774", "species_179838", "G5EDP9", "WBGene00000001", "Q94125", "WBGene00000090" ] }, "reaction_10519952": { "compartment": "compartment_876", "id": "reaction_10519952", "reactome": "R-CEL-380905", "name": "Serotonin loaded synaptic vesicle docking and priming", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10516749", "species_10516777", "species_10519865", "species_10519944", "species_10516744", "species_10516631", "species_10516739" ], "products": [ "species_10519946" ], "modifiers": [ [ "species_10519944", "catalyst" ] ], "additional_components": [ "WBGene00006798", "Q21049", "WBGene00006364", "Q22366", "WBGene00006750", "P27715", "WBGene00006752", "Q9N415", "WBGene00006513", "Q94057", "WBGene00044062", "Q95XH1", "WBGene00022077", "G5EBK2", "WBGene00014084", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q19767", "WBGene00004898", "Q9GNP0", "WBGene00000295", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "Q94986", "WBGene00004267", "species_380585", "WBGene00022271", "WBGene00006757", "G5EEN8", "WBGene00006454", "A5PEW5", "WBGene00004364", "G5EEN8", "WBGene00006454", "A5PEW5", "WBGene00004364", "P34815", "WBGene00006757", "Q94057", "WBGene00044062", "Q95XH1", "WBGene00022077", "G5EBK2", "WBGene00014084", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q19767", "WBGene00004898", "Q9GNP0", "WBGene00000295", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "Q94986", "WBGene00004267", "species_380585", "Q9GUM7", "WBGene00022271", "Q21049", "WBGene00006364", "Q22366", "WBGene00006750", "P27715", "WBGene00006752", "Q9N415", "WBGene00006513", "O16000", "WBGene00006798", "Q94057", "WBGene00044062", "Q95XH1", "WBGene00022077", "G5EBK2", "WBGene00014084", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q19767", "WBGene00004898", "Q9GNP0", "WBGene00000295", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "Q94986", "WBGene00004267", "species_380585" ] }, "reaction_10519894": { "compartment": "compartment_374932", "id": "reaction_10519894", "reactome": "R-CEL-380586", "name": "loading of Serotonin in synaptic vesicles", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_209914" ], "products": [ "species_380585" ], "modifiers": [ [ "species_10518406", "catalyst" ] ], "additional_components": [ "WBGene00000295" ] }, "reaction_10519949": { "compartment": "compartment_984", "id": "reaction_10519949", "reactome": "R-CEL-380901", "name": "Release of docked serotonin loaded synaptic vesicle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10519946" ], "products": [ "species_10518827", "species_114523", "species_10516777", "species_10519865", "species_10516825", "species_10516744", "species_10516631", "species_10516823", "species_10516807" ], "modifiers": [ [ "species_10519946", "catalyst" ] ], "additional_components": [ "G5EEN8", "WBGene00006454", "A5PEW5", "WBGene00004364", "P34815", "WBGene00006757", "Q94057", "WBGene00044062", "Q95XH1", "WBGene00022077", "G5EBK2", "WBGene00014084", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q19767", "WBGene00004898", "Q9GNP0", "WBGene00000295", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "Q94986", "WBGene00004267", "species_380585", "Q9GUM7", "WBGene00022271", "Q21049", "WBGene00006364", "Q22366", "WBGene00006750", "P27715", "WBGene00006752", "Q9N415", "WBGene00006513", "O16000", "WBGene00006798", "WBGene00000295", "Q21049", "WBGene00006364", "Q22366", "WBGene00006750", "P27715", "WBGene00006752", "Q9N415", "WBGene00006513", "WBGene00004267", "WBGene00022271", "WBGene00006757", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "G5EEN8", "WBGene00006454", "A5PEW5", "WBGene00004364", "Q94057", "WBGene00044062", "Q95XH1", "WBGene00022077", "G5EBK2", "WBGene00014084", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q19767", "WBGene00004898", "O16000", "WBGene00006798", "G5EEN8", "WBGene00006454", "A5PEW5", "WBGene00004364", "P34815", "WBGene00006757", "Q94057", "WBGene00044062", "Q95XH1", "WBGene00022077", "G5EBK2", "WBGene00014084", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q19767", "WBGene00004898", "Q9GNP0", "WBGene00000295", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "Q94986", "WBGene00004267", "species_380585", "Q9GUM7", "WBGene00022271", "Q21049", "WBGene00006364", "Q22366", "WBGene00006750", "P27715", "WBGene00006752", "Q9N415", "WBGene00006513", "O16000", "WBGene00006798" ] }, "reaction_10522699": { "compartment": "compartment_876", "id": "reaction_10522699", "reactome": "R-CEL-426223", "name": "Cation influx mediated by TRPC3/6/7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426219" ], "products": [ "species_426221" ], "modifiers": [ [ "species_10522694", "catalyst" ] ], "additional_components": [ "species_83910", "species_74016", "species_114632", "species_74016", "species_114632", "species_83910", "Q8I6Y9", "WBGene00006615", "species_114519" ] }, "reaction_10520082": { "compartment": "compartment_876", "id": "reaction_10520082", "reactome": "R-CEL-381668", "name": "cAMP activates EPAC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10520078", "species_30389" ], "products": [ "species_10520080" ], "modifiers": [], "additional_components": [ "WBGene00004255", "species_30389", "P34578", "WBGene00004255" ] }, "reaction_10520163": { "compartment": "compartment_876", "id": "reaction_10520163", "reactome": "R-CEL-381713", "name": "Potassium voltage-gated channels close in reponse to PKA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10520161" ], "products": [ "species_10520161" ], "modifiers": [ [ "species_10508954", "catalyst" ] ], "additional_components": [ "A0A4V0INI0", "WBGene00002242", "H2KZQ6", "WBGene00001374", "J3K003", "WBGene00007862", "Q20381", "WBGene00018402", "Q9XXD1", "WBGene00012967", "U4PLR3", "WBGene00021948", "A0A3B1E007", "WBGene00004793", "G5EC00", "WBGene00008819", "G5EFC3", "WBGene00001202", "A0A4V0INI0", "WBGene00002242", "H2KZQ6", "WBGene00001374", "J3K003", "WBGene00007862", "Q20381", "WBGene00018402", "Q9XXD1", "WBGene00012967", "U4PLR3", "WBGene00021948", "A0A3B1E007", "WBGene00004793", "G5EC00", "WBGene00008819", "G5EFC3", "WBGene00001202", "WBGene00002189" ] }, "reaction_10520051": { "compartment": "compartment_876", "id": "reaction_10520051", "reactome": "R-CEL-381608", "name": "cAMP activates EPAC2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10520047", "species_30389" ], "products": [ "species_10520049" ], "modifiers": [], "additional_components": [ "WBGene00004255", "species_30389", "P34578", "WBGene00004255" ] }, "reaction_10520167": { "compartment": "compartment_70101", "id": "reaction_10520167", "reactome": "R-CEL-381727", "name": "RAP1A exchanges GDP for GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10520165" ], "products": [ "species_29420", "species_10518164" ], "modifiers": [ [ "species_10520049", "catalyst" ], [ "species_10520080", "catalyst" ] ], "additional_components": [ "Q18246", "WBGene00004307", "species_29420", "Q18246", "WBGene00004307", "species_29438", "species_30389", "P34578", "WBGene00004255", "species_30389", "P34578", "WBGene00004255" ] }, "reaction_10520075": { "compartment": "compartment_12045", "id": "reaction_10520075", "reactome": "R-CEL-381644", "name": "ER calcium channels open in response to activated PKA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10520065" ], "products": [ "species_10520073" ], "modifiers": [ [ "species_10508954", "catalyst" ] ], "additional_components": [ "Q9Y0A1", "WBGene00002173", "Q9Y0A1", "WBGene00002173", "species_114520", "WBGene00002189" ] }, "reaction_10507009": { "compartment": "compartment_350", "id": "reaction_10507009", "reactome": "R-CEL-74986", "name": "Elongation of pre-rRNA transcript", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74985", "species_30595" ], "products": [ "species_74985" ], "modifiers": [ [ "species_10506322", "catalyst" ], [ "species_10507007", "catalyst" ] ], "additional_components": [ "species_110614", "species_29358", "species_29494", "species_29438", "P46064", "WBGene00006430", "O01914", "WBGene00017758", "P32085", "WBGene00006542", "Q19826", "WBGene00017830", "Q9UAY9", "WBGene00019275", "Q9U3I0", "WBGene00009078", "G5ED21", "WBGene00012999", "Q9N5K2", "WBGene00019246", "Q95X83", "WBGene00017749", "Q17684", "WBGene00007355", "Q9GR61", "WBGene00021347", "O17587", "WBGene00007616", "Q27493", "WBGene00008781", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "P34618", "WBGene00000414", "P62784", "WBGene00001875", "K7ZUH9", "WBGene00001914", "Q10453", "WBGene00001945" ] }, "reaction_10506324": { "compartment": "compartment_7660", "id": "reaction_10506324", "reactome": "R-CEL-73769", "name": "Loss of Rrn3 from RNA Polymerase I promoter escape complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10506318" ], "products": [ "species_10506238", "species_10506322" ], "modifiers": [], "additional_components": [ "Q19826", "WBGene00017830", "Q9UAY9", "WBGene00019275", "Q9U3I0", "WBGene00009078", "G5ED21", "WBGene00012999", "Q9N5K2", "WBGene00019246", "Q95X83", "WBGene00017749", "Q17684", "WBGene00007355", "Q9GR61", "WBGene00021347", "O17587", "WBGene00007616", "Q27493", "WBGene00008781", "P48322", "WBGene00007980", "P46064", "WBGene00006430", "O01914", "WBGene00017758", "P32085", "WBGene00006542", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "WBGene00007980", "P46064", "WBGene00006430", "O01914", "WBGene00017758", "P32085", "WBGene00006542", "Q19826", "WBGene00017830", "Q9UAY9", "WBGene00019275", "Q9U3I0", "WBGene00009078", "G5ED21", "WBGene00012999", "Q9N5K2", "WBGene00019246", "Q95X83", "WBGene00017749", "Q17684", "WBGene00007355", "Q9GR61", "WBGene00021347", "O17587", "WBGene00007616", "Q27493", "WBGene00008781", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529" ] }, "reaction_10506242": { "compartment": "compartment_7660", "id": "reaction_10506242", "reactome": "R-CEL-73757", "name": "Binding of RRN3 to RNA Polymerase I", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10506238", "species_10506233" ], "products": [ "species_10506240" ], "modifiers": [], "additional_components": [ "WBGene00007980", "Q19826", "WBGene00017830", "Q9UAY9", "WBGene00019275", "Q9U3I0", "WBGene00009078", "G5ED21", "WBGene00012999", "Q9N5K2", "WBGene00019246", "Q95X83", "WBGene00017749", "Q17684", "WBGene00007355", "Q9GR61", "WBGene00021347", "O17587", "WBGene00007616", "Q27493", "WBGene00008781", "Q19826", "WBGene00017830", "Q9UAY9", "WBGene00019275", "Q9U3I0", "WBGene00009078", "G5ED21", "WBGene00012999", "Q9N5K2", "WBGene00019246", "Q95X83", "WBGene00017749", "Q17684", "WBGene00007355", "Q9GR61", "WBGene00021347", "O17587", "WBGene00007616", "Q27493", "WBGene00008781", "P48322", "WBGene00007980" ] }, "reaction_10544853": { "compartment": "compartment_876", "id": "reaction_10544853", "reactome": "R-CEL-2534365", "name": "Slo3 Potassium Transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10544850", "catalyst" ] ], "additional_components": [ "Q95V25", "WBGene00004830" ] }, "reaction_10544843": { "compartment": "compartment_876", "id": "reaction_10544843", "reactome": "R-CEL-2534346", "name": "SPAM1 Binds Hyaluronic Acid", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10544839", "species_1297302" ], "products": [ "species_10544841" ], "modifiers": [], "additional_components": [ "WBGene00011923", "species_1297302", "G5ECE8", "WBGene00011923" ] }, "reaction_10568369": { "compartment": "compartment_161320", "id": "reaction_10568369", "reactome": "R-CEL-8938108", "name": "SERPINB13 binds cathepsin L", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10568365", "species_10568363" ], "products": [ "species_10568367" ], "modifiers": [], "additional_components": [ "Q93512", "WBGene00019986", "O45734", "WBGene00000776", "Q23030", "WBGene00019986", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "A9Z1L1", "WBGene00005648", "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "A9Z1L1", "WBGene00005648", "G5ECY2", "WBGene00005644", "Q93512", "WBGene00019986", "O45734", "WBGene00000776", "Q23030", "WBGene00019986" ] }, "reaction_10568373": { "compartment": "compartment_161320", "id": "reaction_10568373", "reactome": "R-CEL-8938121", "name": "SERPINB13 binds CTSK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10568363", "species_10542848" ], "products": [ "species_10568371" ], "modifiers": [], "additional_components": [ "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "A9Z1L1", "WBGene00005648", "G5ECY2", "WBGene00005644", "O45734", "WBGene00000776", "Q23030", "WBGene00019986", "Q93512", "WBGene00019986", "O45734", "WBGene00000776", "Q23030", "WBGene00019986", "Q93512", "WBGene00019986", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "A9Z1L1", "WBGene00005648", "G5ECY2", "WBGene00005644" ] }, "reaction_10573076": { "compartment": "compartment_459", "id": "reaction_10573076", "reactome": "R-CEL-9674531", "name": "AAMP binds EGFR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10512185", "species_10573072" ], "products": [ "species_10573074" ], "modifiers": [], "additional_components": [ "WBGene00002299", "WBGene00013735", "E0R7L2", "WBGene00013735", "P24348", "WBGene00002299" ] }, "reaction_10512180": { "compartment": "compartment_70101", "id": "reaction_10512180", "reactome": "R-CEL-177938", "name": "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10512175", "species_29438" ], "products": [ "species_29420", "species_10511481" ], "modifiers": [ [ "species_10512177", "catalyst" ] ], "additional_components": [ "species_29420", "P22981", "WBGene00002335", "species_29438", "P22981", "WBGene00002335", "P24348", "WBGene00002299", "P29355", "WBGene00004774", "Q9N5D3", "WBGene00004947" ] }, "reaction_10508553": { "compartment": "compartment_70101", "id": "reaction_10508553", "reactome": "R-CEL-109813", "name": "GRB2-1 binds SOS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10506876", "species_10506871" ], "products": [ "species_10506878" ], "modifiers": [], "additional_components": [ "WBGene00004947", "WBGene00004774", "P29355", "WBGene00004774", "Q9N5D3", "WBGene00004947" ] }, "reaction_10502745": { "compartment": "compartment_70101", "id": "reaction_10502745", "reactome": "R-CEL-69191", "name": "Formation of Cyclin E:Cdk2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502739", "species_10502737" ], "products": [ "species_10502743" ], "modifiers": [], "additional_components": [ "WBGene00000871", "WBGene00019362", "O61847", "WBGene00019362", "O01501", "WBGene00000871" ] }, "reaction_10509929": { "compartment": "compartment_13231", "id": "reaction_10509929", "reactome": "R-CEL-157906", "name": "Translocation of Cyclin E:Cdk2 complex to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502743" ], "products": [ "species_10502749" ], "modifiers": [], "additional_components": [ "O61847", "WBGene00019362", "O01501", "WBGene00000871", "O61847", "WBGene00019362" ] }, "reaction_10502762": { "compartment": "compartment_7660", "id": "reaction_10502762", "reactome": "R-CEL-69199", "name": "Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10502754" ], "products": [ "species_113550", "species_10502749" ], "modifiers": [ [ "species_10502759", "catalyst" ] ], "additional_components": [ "O01501", "WBGene00000871", "O61847", "WBGene00019362", "O61847", "WBGene00019362", "WBGene00000389" ] }, "reaction_10512702": { "compartment": "compartment_7660", "id": "reaction_10512702", "reactome": "R-CEL-188350", "name": "CAK-mediated phosphorylation of Cyclin E:Cdk2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10502749" ], "products": [ "species_113582", "species_10502596" ], "modifiers": [ [ "species_10506279", "catalyst" ] ], "additional_components": [ "O61847", "WBGene00019362", "O01501", "WBGene00000871", "O61847", "WBGene00019362", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408" ] }, "reaction_10546481": { "compartment": "compartment_70101", "id": "reaction_10546481", "reactome": "R-CEL-3204303", "name": "MRE11 binds cytosolic DNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546477", "species_874088" ], "products": [ "species_10546479" ], "modifiers": [], "additional_components": [ "WBGene00003405", "species_874088", "Q23255", "WBGene00003405" ] }, "reaction_10546391": { "compartment": "compartment_70101", "id": "reaction_10546391", "reactome": "R-CEL-3134946", "name": "DDX41 ubiquitination by TRIM21", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546380", "species_10502375", "species_10530724" ], "products": [ "species_10546388" ], "modifiers": [ [ "species_10530724", "catalyst" ] ], "additional_components": [ "WBGene00019245", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "WBGene00021640", "Q9N3T6", "WBGene00021640", "Q9N5K1", "WBGene00019245", "WBGene00021640" ] }, "reaction_10571225": { "compartment": "compartment_70101", "id": "reaction_10571225", "reactome": "R-CEL-9013869", "name": "DDX41 binds bacterial c-di-AMP, c-di-GMP ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546380", "species_8982080" ], "products": [ "species_10571223" ], "modifiers": [], "additional_components": [ "WBGene00019245", "CHEBI:49537", "CHEBI:47037", "CHEBI:49537", "CHEBI:47037", "Q9N5K1", "WBGene00019245" ] }, "reaction_10513873": { "compartment": "compartment_876", "id": "reaction_10513873", "reactome": "R-CEL-198314", "name": "DAG stimulates protein kinase C-delta", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10513858" ], "products": [ "species_10513870", "species_29370" ], "modifiers": [ [ "species_10513858", "catalyst" ], [ "species_112275", "catalyst" ] ], "additional_components": [ "P34885", "WBGene00004032", "P34722", "WBGene00006599", "P34722", "WBGene00006599", "P34885", "WBGene00004032", "P34885", "WBGene00004032", "P34722", "WBGene00006599" ] }, "reaction_10542115": { "compartment": "compartment_876", "id": "reaction_10542115", "reactome": "R-CEL-2029475", "name": "Production of AA by iPLA2 upon FCGR activation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_426925" ], "products": [ "species_140356", "species_428981" ], "modifiers": [ [ "species_10534904", "catalyst" ] ], "additional_components": [ "WBGene00016661" ] }, "reaction_10542106": { "compartment": "compartment_876", "id": "reaction_10542106", "reactome": "R-CEL-2029471", "name": "Hydrolysis of PC to PA by PLD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_429802", "species_29356" ], "products": [ "species_264618", "species_1602448" ], "modifiers": [ [ "species_10542103", "catalyst" ] ], "additional_components": [ "G5EDU3", "WBGene00004040" ] }, "reaction_10541996": { "compartment": "compartment_70101", "id": "reaction_10541996", "reactome": "R-CEL-2029454", "name": "Autophosphorylation of PAK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10541994", "species_113592" ], "products": [ "species_29370", "species_10520664", "species_10521268" ], "modifiers": [ [ "species_10520670", "catalyst" ] ], "additional_components": [ "species_29438", "Q03206", "ced-10", "Q05062", "WBGene00000390", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "species_29438", "Q03206", "ced-10", "Q05062", "WBGene00000390", "Q17850", "WBGene00003911", "G5EGQ3", "WBGene00003144", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911" ] }, "reaction_10530663": { "compartment": "compartment_876", "id": "reaction_10530663", "reactome": "R-CEL-981539", "name": "C3b binds to cell surface", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10510806", "species_983438" ], "products": [ "species_10530661" ], "modifiers": [], "additional_components": [ "K8F7Z5", "WBGene00008735", "Q7YTU0", "WBGene00013969", "K8F7Z5", "WBGene00008735", "Q7YTU0", "WBGene00013969" ] }, "reaction_10511597": { "compartment": "compartment_984", "id": "reaction_10511597", "reactome": "R-CEL-173739", "name": "Spontaneous hydrolysis of C3 thioester", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10510798", "species_109276" ], "products": [ "species_10511595" ], "modifiers": [], "additional_components": [ "K8F7Z5", "WBGene00008735", "Q7YTU0", "WBGene00013969", "K8F7Z5", "WBGene00008735", "Q7YTU0", "WBGene00013969" ] }, "reaction_10530687": { "compartment": "compartment_876", "id": "reaction_10530687", "reactome": "R-CEL-981713", "name": "C4b binds to cell surface", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_983438", "species_10510784" ], "products": [ "species_10530685" ], "modifiers": [], "additional_components": [ "K8F7Z5", "WBGene00008735", "Q7YTU0", "WBGene00013969", "K8F7Z5", "WBGene00008735", "Q7YTU0", "WBGene00013969" ] }, "reaction_10569040": { "compartment": "compartment_876", "id": "reaction_10569040", "reactome": "R-CEL-8951486", "name": "CD46 binds C4b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10530685", "species_10531687" ], "products": [ "species_10569038" ], "modifiers": [], "additional_components": [ "K8F7Z5", "WBGene00008735", "Q7YTU0", "WBGene00013969", "A0A1N7SYP5", "WBGene00009500", "Q18849", "WBGene00009500", "Q22328", "WBGene00002976", "A0A1N7SYP5", "WBGene00009500", "Q18849", "WBGene00009500", "Q22328", "WBGene00002976", "K8F7Z5", "WBGene00008735", "Q7YTU0", "WBGene00013969" ] }, "reaction_10531691": { "compartment": "compartment_876", "id": "reaction_10531691", "reactome": "R-CEL-1006143", "name": "CD46 binds C3b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10531687", "species_10530661" ], "products": [ "species_10531689" ], "modifiers": [], "additional_components": [ "A0A1N7SYP5", "WBGene00009500", "Q18849", "WBGene00009500", "Q22328", "WBGene00002976", "K8F7Z5", "WBGene00008735", "Q7YTU0", "WBGene00013969", "K8F7Z5", "WBGene00008735", "Q7YTU0", "WBGene00013969", "A0A1N7SYP5", "WBGene00009500", "Q18849", "WBGene00009500", "Q22328", "WBGene00002976" ] }, "reaction_10565402": { "compartment": "compartment_984", "id": "reaction_10565402", "reactome": "R-CEL-8852809", "name": "CPN, CPB2 cleave C3a, C5a", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10565379" ], "products": [ "species_10565381" ], "modifiers": [ [ "species_10565399", "catalyst" ] ], "additional_components": [ "K8F7Z5", "WBGene00008735", "Q7YTU0", "WBGene00013969", "K8F7Z5", "WBGene00008735", "Q7YTU0", "WBGene00013969", "Q22825", "WBGene00012073", "O17754", "WBGene00001189", "Q9N5Z3", "WBGene00006593", "Q9TZC6", "WBGene00021984", "G3MU29", "WBGene00021984", "Q9XU75", "WBGene00011235", "G5EC13", "WBGene00021984", "G5EC96", "WBGene00021984", "H2L0D7", "WBGene00021984", "H2L0K5", "WBGene00021984", "Q6A577", "WBGene00021984", "Q9BL88", "WBGene00021984" ] }, "reaction_10545918": { "compartment": "compartment_984", "id": "reaction_10545918", "reactome": "R-CEL-2855047", "name": "Hydrolysis of internal thioester in C4b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_10510784" ], "products": [ "species_10530671" ], "modifiers": [], "additional_components": [ "K8F7Z5", "WBGene00008735", "Q7YTU0", "WBGene00013969", "K8F7Z5", "WBGene00008735", "Q7YTU0", "WBGene00013969" ] }, "reaction_10529380": { "compartment": "compartment_70101", "id": "reaction_10529380", "reactome": "R-CEL-936563", "name": "ISGylation of DDX58", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10529344", "species_10529376" ], "products": [ "species_10529378" ], "modifiers": [], "additional_components": [ "WBGene00008400", "P91057", "WBGene00015842", "Q9BL11", "WBGene00021685", "Q21633", "WBGene00006713", "Q27481", "WBGene00006699", "P91057", "WBGene00015842", "Q9BL11", "WBGene00021685", "Q21633", "WBGene00006713", "Q27481", "WBGene00006699", "Q93413", "WBGene00008400" ] }, "reaction_10529352": { "compartment": "compartment_70101", "id": "reaction_10529352", "reactome": "R-CEL-936390", "name": "CYLD mediated deubiquitination of DDX58 (RIG-I)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10529342" ], "products": [ "species_10502375", "species_10529344" ], "modifiers": [ [ "species_10529349", "catalyst" ] ], "additional_components": [ "WBGene00008400", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "WBGene00008400", "WBGene00009594" ] }, "reaction_10515197": { "compartment": "compartment_70101", "id": "reaction_10515197", "reactome": "R-CEL-202164", "name": "Translocation of PDK1 to Plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10515193", "species_202277" ], "products": [ "species_10515195" ], "modifiers": [], "additional_components": [ "WBGene00021022", "species_202247", "species_179838", "Q9UA62", "WBGene00021022", "species_202247", "species_179838" ] }, "reaction_10515220": { "compartment": "compartment_70101", "id": "reaction_10515220", "reactome": "R-CEL-202328", "name": "Translocation of PKC theta to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10514851", "species_112275" ], "products": [ "species_10515218" ], "modifiers": [], "additional_components": [ "WBGene00006599", "P34722", "WBGene00006599", "species_112275" ] }, "reaction_10545484": { "compartment": "compartment_70101", "id": "reaction_10545484", "reactome": "R-CEL-2730835", "name": "Autophosphorylation of PKC-theta", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10515204" ], "products": [ "species_10545482", "species_29370" ], "modifiers": [], "additional_components": [ "P34722", "WBGene00006599", "species_112275", "species_112275", "P34722", "WBGene00006599" ] }, "reaction_10545501": { "compartment": "compartment_876", "id": "reaction_10545501", "reactome": "R-CEL-2730862", "name": "Autophosphorylation of LYN kinase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10545490" ], "products": [ "species_10545498", "species_29370" ], "modifiers": [ [ "species_10545490", "catalyst" ] ], "additional_components": [ "Q9N3S5", "WBGene00021635", "G5EE56", "WBGene00005077", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q9N3S5", "WBGene00021635", "G5EE56", "WBGene00005077" ] }, "reaction_10560563": { "compartment": "compartment_6799713", "id": "reaction_10560563", "reactome": "R-CEL-6798747", "name": "Exocytosis of tertiary granule membrane proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10560495" ], "products": [ "species_10560561" ], "modifiers": [], "additional_components": [ "G5EE29", "WBGene00021404", "P91448", "WBGene00004149", "Q19377", "WBGene00008731", "Q23141", "WBGene00020972", "A5PEW5", "WBGene00004364", "G5EEN8", "WBGene00006454", "Q20325", "WBGene00018344", "Q9XUK8", "WBGene00012275", "Q19958", "WBGene00006064", "A0AAC1", "WBGene00012424", "Q21557", "WBGene00010888", "Q22799", "WBGene00001005", "Q65XS9", "WBGene00043067", "Q7YTJ8", "WBGene00012425", "A0A1D3PCM0", "WBGene00270320", "G5EDW5", "WBGene00000074", "G5EFD5", "WBGene00006804", "Q19844", "WBGene00270320", "G5EBK2", "WBGene00014084", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q19767", "WBGene00004898", "Q94057", "WBGene00044062", "Q95XH1", "WBGene00022077", "G5EFD9", "WBGene00006324", "Q9TYL9", "WBGene00021292", "Q9XTY9", "WBGene00010993", "O18076", "WBGene00011668", "O44871", "WBGene00019914", "P91214", "WBGene00017199", "Q21146", "WBGene00019328", "Q9N4W4", "WBGene00021602", "Q9N4W5", "WBGene00021603", "G5EDU3", "WBGene00004040", "U4PBV8", "WBGene00019166", "C0HLB3", "WBGene00006911", "C0HLB4", "WBGene00006912", "Q20707", "WBGene00006630", "G4RWX0", "WBGene00006632", "H2L006", "WBGene00006640", "Q22495", "WBGene00006638", "O62466", "WBGene00006631", "G5ECY2", "WBGene00005644", "Q9NEI8", "WBGene00043980", "A0A0S4XR36", "C44E4.1d", "P22981", "WBGene00002335", "Q27874", "WBGene00003930", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "O17599", "WBGene00004308", "Q93874", "WBGene00004276", "O01312", "WBGene00004309", "Q21433", "WBGene00004877", "Q21434", "WBGene00004876", "Q95XG8", "WBGene00004878", "Q23022", "WBGene00006774", "P34446", "WBGene00003929", "C0HLB4", "WBGene00006912", "C0HLB3", "WBGene00006911", "U4PBV8", "WBGene00019166", "Q22799", "WBGene00001005", "Q65XS9", "WBGene00043067", "Q7YTJ8", "WBGene00012425", "A0AAC1", "WBGene00012424", "Q21557", "WBGene00010888", "Q19377", "WBGene00008731", "Q23141", "WBGene00020972", "G5EE29", "WBGene00021404", "P91448", "WBGene00004149", "O18076", "WBGene00011668", "O44871", "WBGene00019914", "P91214", "WBGene00017199", "Q21146", "WBGene00019328", "Q9N4W4", "WBGene00021602", "Q9N4W5", "WBGene00021603", "Q21433", "WBGene00004877", "Q21434", "WBGene00004876", "Q95XG8", "WBGene00004878", "Q9TYL9", "WBGene00021292", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "Q9XTY9", "WBGene00010993", "P22981", "WBGene00002335", "Q93874", "WBGene00004276", "Q19958", "WBGene00006064", "Q23022", "WBGene00006774", "G5ECY2", "WBGene00005644", "O17599", "WBGene00004308", "O01312", "WBGene00004309", "Q9NEI8", "WBGene00043980", "Q95XH1", "WBGene00022077", "G5EBK2", "WBGene00014084", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q19767", "WBGene00004898", "Q94057", "WBGene00044062", "G5EEN8", "WBGene00006454", "A5PEW5", "WBGene00004364", "Q19844", "WBGene00270320", "A0A1D3PCM0", "WBGene00270320", "G5EDW5", "WBGene00000074", "G5EFD5", "WBGene00006804", "O62466", "WBGene00006631", "Q20707", "WBGene00006630", "Q22495", "WBGene00006638", "G4RWX0", "WBGene00006632", "H2L006", "WBGene00006640", "G5EFD9", "WBGene00006324", "G5EDU3", "WBGene00004040", "Q27874", "WBGene00003930", "P34446", "WBGene00003929", "Q20325", "WBGene00018344", "Q9XUK8", "WBGene00012275", "A0A0S4XR36", "C44E4.1d" ] }, "reaction_10561604": { "compartment": "compartment_1470028", "id": "reaction_10561604", "reactome": "R-CEL-6798751", "name": "Exocytosis of azurophil granule lumen proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10559966" ], "products": [ "species_10560050" ], "modifiers": [], "additional_components": [ "G5EFI4", "WBGene00002268", "A0A486WWU7", "WBGene00000110", "O44555", "WBGene00000111", "Q965W1", "WBGene00021486", "G5ED36", "WBGene00004378", "A0A1N7SYP5", "WBGene00009500", "Q18849", "WBGene00009500", "Q22328", "WBGene00002976", "O62403", "WBGene00013782", "Q20748", "WBGene00010015", "P30628", "WBGene00006768", "O17772", "WBGene00003980", "P34446", "WBGene00003929", "G5ECY2", "WBGene00005644", "Q03206", "ced-10", "G5ED34", "WBGene00001007", "Q94148", "WBGene00004273", "Q19479", "WBGene00008848", "Q7JP75", "WBGene00000872", "E6N0V1", "WBGene00018819", "Q8MXS1", "WBGene00004277", "G5ECX0", "WBGene00002252", "Q94986", "WBGene00004267", "P55163", "WBGene00001580", "P91857", "WBGene00004268", "Q22601", "WBGene00000161", "Q9NEI8", "WBGene00043980", "P34213", "WBGene00004269", "Q22782", "WBGene00004270", "A9Z1L1", "WBGene00005648", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "Q23146", "WBGene00004271", "Q22038", "WBGene00004357", "Q18673", "WBGene00013926", "P91214", "WBGene00017199", "Q21146", "WBGene00019328", "Q9N4W4", "WBGene00021602", "Q9N4W5", "WBGene00021603", "O18076", "WBGene00011668", "O44871", "WBGene00019914", "Q22531", "WBGene00011803", "Q9TYL9", "WBGene00021292", "O62403", "WBGene00013782", "Q94148", "WBGene00004273", "Q8MXS1", "WBGene00004277", "P91857", "WBGene00004268", "P34213", "WBGene00004269", "Q22782", "WBGene00004270", "O18076", "WBGene00011668", "O44871", "WBGene00019914", "P91214", "WBGene00017199", "Q21146", "WBGene00019328", "Q9N4W4", "WBGene00021602", "Q9N4W5", "WBGene00021603", "Q23146", "WBGene00004271", "Q9TYL9", "WBGene00021292", "Q22038", "WBGene00004357", "Q965W1", "WBGene00021486", "Q22531", "WBGene00011803", "Q20748", "WBGene00010015", "Q22328", "WBGene00002976", "A0A1N7SYP5", "WBGene00009500", "Q18849", "WBGene00009500", "P30628", "WBGene00006768", "A0A486WWU7", "WBGene00000110", "O44555", "WBGene00000111", "G5ECY2", "WBGene00005644", "G5ED34", "WBGene00001007", "Q9NEI8", "WBGene00043980", "Q19479", "WBGene00008848", "Q7JP75", "WBGene00000872", "E6N0V1", "WBGene00018819", "P55163", "WBGene00001580", "P34446", "WBGene00003929", "O17772", "WBGene00003980", "Q03206", "ced-10", "G5ED36", "WBGene00004378", "Q19651", "WBGene00005649", "A9Z1L1", "WBGene00005648", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q22601", "WBGene00000161", "G5ECX0", "WBGene00002252", "Q94986", "WBGene00004267", "Q18673", "WBGene00013926", "G5EFI4", "WBGene00002268" ] }, "reaction_10559815": { "compartment": "compartment_6798757", "id": "reaction_10559815", "reactome": "R-CEL-6798739", "name": "Exocytosis of azurophil granule membrane proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10559673" ], "products": [ "species_10559813" ], "modifiers": [], "additional_components": [ "Q22630", "WBGene00011879", "E7EM30", "WBGene00206373", "Q19175", "WBGene00008560", "O17373", "WBGene00020471", "Q23534", "WBGene00022770", "Q19390", "WBGene00017427", "Q95PW2", "WBGene00206373", "P90949", "WBGene00011262", "Q19460", "WBGene00008801", "Q09448", "WBGene00007328", "Q95QK6", "WBGene00008804", "Q19461", "WBGene00008802", "Q9BL40", "WBGene00022181", "Q09451", "WBGene00007331", "Q20662", "WBGene00018696", "A0A061AJ50", "WBGene00206373", "Q10944", "WBGene00015161", "E7EM29", "WBGene00016152", "Q9GUF1", "WBGene00022246", "Q22525", "WBGene00004023", "Q9GUF2", "WBGene00022245", "Q19076", "WBGene00004020", "Q94986", "WBGene00004267", "Q95XH1", "WBGene00022077", "G5EBK2", "WBGene00014084", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q19767", "WBGene00004898", "Q94057", "WBGene00044062", "Q01608", "WBGene00004958", "O02100", "WBGene00001985", "P52166", "WBGene00004769", "Q9XXA4", "WBGene00007067", "Q19958", "WBGene00006064", "P91857", "WBGene00004268", "Q9U280", "WBGene00013034", "P34676", "WBGene00022801", "Q18864", "WBGene00004788", "G5EDC6", "WBGene00000192", "Q18276", "WBGene00004995", "Q18246", "WBGene00004307", "O76735", "WBGene00004912", "Q11117", "WBGene00003053", "Q9GYK0", "WBGene00015471", "H2KZR1", "WBGene00019780", "P83386", "WBGene00019780", "Q21228", "WBGene00019780", "D9N147", "WBGene00019780", "P83387", "WBGene00019780", "Q18582", "WBGene00019780", "P83351", "WBGene00019305", "G5ED36", "WBGene00004378", "E5QCE7", "WBGene00001032", "Q95QX5", "WBGene00015561", "P45971", "WBGene00011638", "C0HLB3", "WBGene00006911", "C0HLB4", "WBGene00006912", "Q93324", "WBGene00007904", "O76663", "WBGene00015246", "P34669", "WBGene00022793", "P91245", "WBGene00017385", "Q9BL33", "WBGene00022169", "Q23316", "WBGene00000148", "Q9XWC5", "WBGene00019346", "Q23151", "WBGene00012224", "H2L0H3", "WBGene00019946", "Q19635", "WBGene00008969", "Q17441", "WBGene00006646", "C0HLB4", "WBGene00006912", "C0HLB3", "WBGene00006911", "P52166", "WBGene00004769", "Q01608", "WBGene00004958", "O02100", "WBGene00001985", "Q9XWC5", "WBGene00019346", "H2L0H3", "WBGene00019946", "Q19635", "WBGene00008969", "Q23151", "WBGene00012224", "G5EDC6", "WBGene00000192", "Q9GYK0", "WBGene00015471", "Q11117", "WBGene00003053", "E5QCE7", "WBGene00001032", "P34669", "WBGene00022793", "Q19958", "WBGene00006064", "Q9U280", "WBGene00013034", "P91245", "WBGene00017385", "Q17441", "WBGene00006646", "Q93324", "WBGene00007904", "Q09448", "WBGene00007328", "Q9GUF2", "WBGene00022245", "Q09451", "WBGene00007331", "Q10944", "WBGene00015161", "Q19076", "WBGene00004020", "Q19175", "WBGene00008560", "Q19390", "WBGene00017427", "Q19460", "WBGene00008801", "Q19461", "WBGene00008802", "Q20662", "WBGene00018696", "Q22525", "WBGene00004023", "Q22630", "WBGene00011879", "A0A061AJ50", "WBGene00206373", "Q23534", "WBGene00022770", "E7EM29", "WBGene00016152", "Q95PW2", "WBGene00206373", "E7EM30", "WBGene00206373", "Q95QK6", "WBGene00008804", "O17373", "WBGene00020471", "Q9BL40", "WBGene00022181", "P90949", "WBGene00011262", "Q9GUF1", "WBGene00022246", "Q95XH1", "WBGene00022077", "G5EBK2", "WBGene00014084", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q19767", "WBGene00004898", "Q94057", "WBGene00044062", "P34676", "WBGene00022801", "Q23316", "WBGene00000148", "Q18276", "WBGene00004995", "D9N147", "WBGene00019780", "H2KZR1", "WBGene00019780", "P83386", "WBGene00019780", "P83387", "WBGene00019780", "Q18582", "WBGene00019780", "Q21228", "WBGene00019780", "P45971", "WBGene00011638", "G5ED36", "WBGene00004378", "Q94986", "WBGene00004267", "O76663", "WBGene00015246", "Q9XXA4", "WBGene00007067", "Q18246", "WBGene00004307", "Q9BL33", "WBGene00022169", "P91857", "WBGene00004268", "Q18864", "WBGene00004788", "P83351", "WBGene00019305", "O76735", "WBGene00004912", "Q95QX5", "WBGene00015561" ] }, "reaction_10562822": { "compartment": "compartment_984", "id": "reaction_10562822", "reactome": "R-CEL-6800434", "name": "Exocytosis of ficolin-rich granule lumen proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10562768" ], "products": [ "species_10562820" ], "modifiers": [], "additional_components": [ "O45686", "WBGene00010769", "Q27483", "WBGene00008230", "Q9TZL8", "WBGene00022199", "Q21966", "WBGene00000217", "P43510", "WBGene00000786", "Q8MYL7", "WBGene00013220", "O62334", "WBGene00011050", "Q18688", "WBGene00000915", "P28548", "WBGene00002196", "O61792", "WBGene00004464", "P09446", "WBGene00002005", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "P04630", "WBGene00000285", "Q09665", "WBGene00006583", "A0A2C9C3L3", "WBGene00020378", "Q09980", "WBGene00017394", "G5EDZ8", "WBGene00000288", "Q11083", "WBGene00020378", "G5EEG0", "WBGene00000286", "Q18136", "WBGene00006861", "G5EF37", "WBGene00003934", "Q94288", "WBGene00000287", "Q20585", "WBGene00004463", "G5EC99", "WBGene00009691", "G5ECU5", "WBGene00009691", "O45246", "WBGene00002026", "Q04908", "WBGene00004460", "Q9GZH5", 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"WBGene00011050", "O61792", "WBGene00004464", "Q20585", "WBGene00004463" ] }, "reaction_10561224": { "compartment": "compartment_6799371", "id": "reaction_10561224", "reactome": "R-CEL-6798749", "name": "Exocytosis of specific granule lumen proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10561178" ], "products": [ "species_10561222" ], "modifiers": [], "additional_components": [ "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "Q21182", "WBGene00194737", "O61967", "WBGene00002632", "Q21408", "WBGene00004951", "O44131", "WBGene00015620", "G5EBT7", "WBGene00000583", "G5EGP1", "WBGene00006845", "Q19137", "WBGene00008543", "G5EFB5", "WBGene00000777", "G5EC24", "WBGene00004214", "O01824", "WBGene00019008", "G5EBS5", "WBGene00000089", "Q19202", "WBGene00017244", "Q10953", "WBGene00006943", "Q18825", "WBGene00000238", "O44326", "WBGene00001979", "H2KZY5", "WBGene00018533", "Q11174", "WBGene00000503", "Q93565", "WBGene00006578", "P19826", "WBGene00000942", "O44518", "WBGene00001579", "Q19349", "WBGene00017376", "Q966Q0", "WBGene00017376", "G5EBT9", "WBGene00010418", "Q9N5N3", "WBGene00019178", "G5EEN3", "WBGene00000419", "O45539", "WBGene00005078", "Q10011", "WBGene00020563", "Q304D5", "WBGene00016278", "A0A1X7RC97", "WBGene00020658", "Q9BIB8", "WBGene00002075", "Q21966", "WBGene00000217", "O62349", "WBGene00011253", "Q93377", "WBGene00008093", "Q09498", "WBGene00008051", "Q18740", "WBGene00008231", "Q9U2X1", "WBGene00013764", "Q9XWA4", "WBGene00013764", "Q9XXQ7", "WBGene00013764", "G5EGP8", "WBGene00000788", "P92005", "WBGene00000789", "Q304D5", "WBGene00016278", "Q21182", "WBGene00194737", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "Q9BIB8", "WBGene00002075", "O61967", "WBGene00002632", "G5EBS5", "WBGene00000089", "Q93565", "WBGene00006578", "H2KZY5", "WBGene00018533", "Q21408", "WBGene00004951", "O44518", "WBGene00001579", "P19826", "WBGene00000942", "Q21966", "WBGene00000217", "O44326", "WBGene00001979", "Q10953", "WBGene00006943", "Q18825", "WBGene00000238", "O44131", "WBGene00015620", "O01824", "WBGene00019008", "A0A1X7RC97", "WBGene00020658", "O45539", "WBGene00005078", "G5EBT9", "WBGene00010418", "Q19202", "WBGene00017244", "G5EC24", "WBGene00004214", "Q10011", "WBGene00020563", "Q9XWA4", "WBGene00013764", "Q9XXQ7", "WBGene00013764", "G5EGP8", "WBGene00000788", "P92005", "WBGene00000789", "Q18740", "WBGene00008231", "Q9U2X1", "WBGene00013764", "G5EBT7", "WBGene00000583", "G5EGP1", "WBGene00006845", "Q19137", "WBGene00008543", "Q19349", "WBGene00017376", "Q966Q0", "WBGene00017376", "G5EFB5", "WBGene00000777", "Q9N5N3", "WBGene00019178", "O62349", "WBGene00011253", "Q11174", "WBGene00000503", "Q09498", "WBGene00008051", "Q93377", "WBGene00008093", "G5EEN3", "WBGene00000419" ] }, "reaction_10560312": { "compartment": "compartment_6800173", "id": "reaction_10560312", "reactome": "R-CEL-6798745", "name": "Exocytosis of tertiary granule lumen proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10560232" ], "products": [ "species_10560310" ], "modifiers": [], "additional_components": [ "Q20587", "WBGene00044310", "Q22993", "WBGene00018811", "Q4W5T6", "WBGene00044310", "O62349", "WBGene00011253", "U4PBQ7", "WBGene00015250", "Q20911", "WBGene00013855", "A8WFK8", "WBGene00016619", "O45686", "WBGene00010769", "Q9N5N3", "WBGene00019178", "H2KZY5", "WBGene00018533", "Q19349", "WBGene00017376", "Q966Q0", "WBGene00017376", "Q19202", "WBGene00017244", "Q11174", "WBGene00000503", "G5EC24", "WBGene00004214", "G5EFB5", "WBGene00000777", "Q21408", "WBGene00004951", "O44518", "WBGene00001579", "Q21966", "WBGene00000217", "H9G2T4", "WBGene00010317", "G5EBT9", "WBGene00010418", "O45734", "WBGene00000776", "Q23030", "WBGene00019986", "Q93512", "WBGene00019986", "G5ECM9", "WBGene00000534", "Q9U204", "WBGene00013323", "Q20628", "WBGene00000392", "Q19137", "WBGene00008543", "G5EBT7", "WBGene00000583", "G5EGP1", "WBGene00006845", "Q9XUT0", "WBGene00010664", "O16453", "WBGene00001500", "Q9TYS3", "WBGene00001501", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "Q21182", "WBGene00194737", "P54216", "WBGene00011474", "P46563", "WBGene00017166", "Q21742", "WBGene00019890", "G5EFT4", "WBGene00016589", "Q09498", "WBGene00008051", "Q93377", "WBGene00008093", "G5ECM9", "WBGene00000534", "Q21182", "WBGene00194737", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "Q9XUT0", "WBGene00010664", "O16453", "WBGene00001500", "Q9TYS3", "WBGene00001501", "H2KZY5", "WBGene00018533", "O44518", "WBGene00001579", "Q21408", "WBGene00004951", "O45734", "WBGene00000776", "Q23030", "WBGene00019986", "Q93512", "WBGene00019986", "Q9U204", "WBGene00013323", "G5EFT4", "WBGene00016589", "Q21966", "WBGene00000217", "H9G2T4", "WBGene00010317", "Q21742", "WBGene00019890", "A8WFK8", "WBGene00016619", "Q20911", "WBGene00013855", "Q20587", "WBGene00044310", "Q22993", "WBGene00018811", "Q4W5T6", "WBGene00044310", "G5EBT9", "WBGene00010418", "O45686", "WBGene00010769", "P46563", "WBGene00017166", "P54216", "WBGene00011474", "Q19202", "WBGene00017244", "G5EC24", "WBGene00004214", "Q11174", "WBGene00000503", "U4PBQ7", "WBGene00015250", "G5EBT7", "WBGene00000583", "G5EGP1", "WBGene00006845", "Q19137", "WBGene00008543", "Q19349", "WBGene00017376", "Q966Q0", "WBGene00017376", "G5EFB5", "WBGene00000777", "Q9N5N3", "WBGene00019178", "O62349", "WBGene00011253", "Q09498", "WBGene00008051", "Q93377", "WBGene00008093", "Q20628", "WBGene00000392" ] }, "reaction_10562427": { "compartment": "compartment_6800424", "id": "reaction_10562427", "reactome": "R-CEL-6800426", "name": "Exocytosis of ficolin-rich granule membrane proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10562381" ], "products": [ "species_10562425" ], "modifiers": [], "additional_components": [ "A9Z1L1", "WBGene00005648", "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "Q19479", "WBGene00008848", "Q7JP75", "WBGene00000872", "E6N0V1", "WBGene00018819", "A0A1D3PCM0", "WBGene00270320", "G5EDW5", "WBGene00000074", "G5EFD5", "WBGene00006804", "Q19844", "WBGene00270320", "A0A0S4XR36", "C44E4.1d", "O45359", "WBGene00020195", "Q17540", "WBGene00020195", "Q22129", "WBGene00020195", "G5ECX0", "WBGene00002252", "Q21146", "WBGene00019328", "Q9N4W4", "WBGene00021602", "Q9N4W5", "WBGene00021603", "O18076", "WBGene00011668", "O44871", "WBGene00019914", "P91214", "WBGene00017199", "Q19833", "WBGene00017837", "P55163", "WBGene00001580", "A0A1N7SYP5", "WBGene00009500", "Q18849", "WBGene00009500", "Q22328", "WBGene00002976", "Q27874", "WBGene00003930", "G5EFI4", "WBGene00002268", "C0HLB3", "WBGene00006911", "C0HLB4", "WBGene00006912", "Q03206", "ced-10", "Q22601", "WBGene00000161", "P34676", "WBGene00022801", "Q22038", "WBGene00004357", "G5EGJ5", "WBGene00002048", "Q95XG8", "WBGene00004878", "Q21433", "WBGene00004877", "Q21434", "WBGene00004876", "Q11117", "WBGene00003053", "Q9GYK0", "WBGene00015471", "Q53U87", "WBGene00004732", "G5EDC6", "WBGene00000192", "G5EE29", "WBGene00021404", "P91448", "WBGene00004149", "Q19377", "WBGene00008731", "Q23141", "WBGene00020972", "Q20748", "WBGene00010015", "A0AAC1", "WBGene00012424", "Q21557", "WBGene00010888", "Q22799", "WBGene00001005", "Q65XS9", "WBGene00043067", "Q7YTJ8", "WBGene00012425", "Q9NEI8", "WBGene00043980", "P30628", "WBGene00006768", "Q19319", "WBGene00000396", "B2MZD0", "WBGene00006916", "G5EEK9", "WBGene00006914", "G5EGP4", "WBGene00006915", "Q9U308", "WBGene00002175", "O44873", "WBGene00019915", "P34446", "WBGene00003929", "G5ED34", "WBGene00001007", "Q9TYL9", "WBGene00021292", "Q9XTY9", "WBGene00010993", "A0A1N7SYP3", "WBGene00006876", "C0HLB4", "WBGene00006912", "C0HLB3", "WBGene00006911", "A0A1N7SYP3", "WBGene00006876", "G5EEK9", "WBGene00006914", "G5EGP4", "WBGene00006915", "P30628", "WBGene00006768", "B2MZD0", "WBGene00006916", "Q22799", "WBGene00001005", "Q65XS9", "WBGene00043067", "Q7YTJ8", "WBGene00012425", "A0AAC1", "WBGene00012424", "Q21557", "WBGene00010888", "Q19377", "WBGene00008731", "Q23141", "WBGene00020972", "G5EE29", "WBGene00021404", "P91448", "WBGene00004149", "G5EDC6", "WBGene00000192", "Q22038", "WBGene00004357", "O18076", "WBGene00011668", "O44871", "WBGene00019914", "P91214", "WBGene00017199", "Q21146", "WBGene00019328", "Q9N4W4", "WBGene00021602", "Q9N4W5", "WBGene00021603", "Q21433", "WBGene00004877", "Q21434", "WBGene00004876", "Q95XG8", "WBGene00004878", "Q9TYL9", "WBGene00021292", "Q9XTY9", "WBGene00010993", "Q20748", "WBGene00010015", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "A9Z1L1", "WBGene00005648", "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "Q11117", "WBGene00003053", "Q9GYK0", "WBGene00015471", "G5ED34", "WBGene00001007", "Q19319", "WBGene00000396", "Q9NEI8", "WBGene00043980", "Q19479", "WBGene00008848", "Q7JP75", "WBGene00000872", "E6N0V1", "WBGene00018819", "P55163", "WBGene00001580", "P34676", "WBGene00022801", "Q19844", "WBGene00270320", "A0A1D3PCM0", "WBGene00270320", "G5EDW5", "WBGene00000074", "G5EFD5", "WBGene00006804", "P34446", "WBGene00003929", "Q27874", "WBGene00003930", "Q53U87", "WBGene00004732", "G5EGJ5", "WBGene00002048", "Q03206", "ced-10", "O44873", "WBGene00019915", "Q22601", "WBGene00000161", "G5ECX0", "WBGene00002252", "A0A0S4XR36", "C44E4.1d", "O45359", "WBGene00020195", "Q17540", "WBGene00020195", "Q22129", "WBGene00020195", "A0A1N7SYP5", "WBGene00009500", "Q18849", "WBGene00009500", "Q22328", "WBGene00002976", "Q19833", "WBGene00017837", "Q9U308", "WBGene00002175", "G5EFI4", "WBGene00002268" ] }, "reaction_10562074": { "compartment": "compartment_6799351", "id": "reaction_10562074", "reactome": "R-CEL-6799350", "name": "Exocytosis of specific granule membrane proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10562030" ], "products": [ "species_10562072" ], "modifiers": [], "additional_components": [ "G5EC93", "WBGene00022014", "O16547", "WBGene00022014", "O44616", "WBGene00022014", "O44827", "WBGene00019207", "O45920", "WBGene00022014", "Q11114", "WBGene00022014", "Q19376", "WBGene00022014", "Q20734", "WBGene00022014", "Q23535", "WBGene00006865", "Q23626", "WBGene00022014", "Q95QY6", "WBGene00022014", "Q9GPA2", "WBGene00022014", "Q9N309", "WBGene00022014", "Q9U2K5", "WBGene00022014", "Q9XU83", "WBGene00022014", "Q9XVL3", "WBGene00022014", "G5EED5", "WBGene00004743", "Q9N4W4", "WBGene00021602", "Q9N4W5", "WBGene00021603", "O18076", "WBGene00011668", "O44871", "WBGene00019914", "P91214", "WBGene00017199", "Q21146", "WBGene00019328", "A5PEW5", "WBGene00004364", "Q20325", "WBGene00018344", "Q9XUK8", "WBGene00012275", "G5EGJ9", "WBGene00009717", "Q9NCE1", "WBGene00010408", "G5EEN8", "WBGene00006454", 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"WBGene00012224", "Q20734", "WBGene00022014", "O16547", "WBGene00022014", "Q9XU83", "WBGene00022014", "Q23535", "WBGene00006865", "O44616", "WBGene00022014", "Q9XVL3", "WBGene00022014", "Q23626", "WBGene00022014", "O44827", "WBGene00019207", "Q95QY6", "WBGene00022014", "O45920", "WBGene00022014", "Q9GPA2", "WBGene00022014", "Q11114", "WBGene00022014", "Q9N309", "WBGene00022014", "Q19376", "WBGene00022014", "G5EC93", "WBGene00022014", "Q9U2K5", "WBGene00022014", "Q19377", "WBGene00008731", "Q23141", "WBGene00020972", "G5EE29", "WBGene00021404", "P91448", "WBGene00004149", "Q9N2U6", "WBGene00022402", "Q22267", "WBGene00011543", "Q8WQG5", "WBGene00007390", "P35602", "WBGene00006829", "Q19958", "WBGene00006064", "E5QCE7", "WBGene00001032", "Q23022", "WBGene00006774", "A0A486WWU7", "WBGene00000110", "O44555", "WBGene00000111", "Q9U280", "WBGene00013034", "G5EC63", "WBGene00013197", "O44186", "WBGene00017996", "O01312", "WBGene00004309", "O17599", "WBGene00004308", "Q9NCE1", "WBGene00010408", "G5EGJ9", "WBGene00009717", "Q9NEI8", "WBGene00043980", "Q95XH1", "WBGene00022077", "G5EBK2", "WBGene00014084", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q19767", "WBGene00004898", "Q94057", "WBGene00044062", "Q19878", "WBGene00009218", "Q18916", "WBGene00017012", "G5EEN8", "WBGene00006454", "A5PEW5", "WBGene00004364", "Q19844", "WBGene00270320", "A0A1D3PCM0", "WBGene00270320", "G5EDW5", "WBGene00000074", "G5EFD5", "WBGene00006804", "Q19930", "WBGene00017947", "O62466", "WBGene00006631", "Q20707", "WBGene00006630", "Q22495", "WBGene00006638", "G4RWX0", "WBGene00006632", "H2L006", "WBGene00006640", "Q10956", "WBGene00015148", "G5EFD9", "WBGene00006324", "G5EDU3", "WBGene00004040", "Q95QG1", "WBGene00018423", "Q27874", "WBGene00003930", "A0A4V0IKG6", "WBGene00007287", "D9N147", "WBGene00019780", "H2KZR1", "WBGene00019780", "P83386", "WBGene00019780", "P83387", "WBGene00019780", "Q18582", "WBGene00019780", "Q21228", "WBGene00019780", "Q9XXA4", "WBGene00007067", "Q18246", "WBGene00004307", "Q9N3Y5", "WBGene00021537", "Q20241", "WBGene00006470", "Q8MQ55", "WBGene00009580", "P34462", "WBGene00010130", "Q20325", "WBGene00018344", "Q9XUK8", "WBGene00012275", "G5EED5", "WBGene00004743", "P91214", "WBGene00017199", "Q21146", "WBGene00019328", "Q9N4W4", "WBGene00021602", "Q9N4W5", "WBGene00021603", "O18076", "WBGene00011668", "O44871", "WBGene00019914", "A0A0S4XR36", "C44E4.1d", "P34446", "WBGene00003929", "Q95QX5", "WBGene00015561", "O44836", "WBGene00019212" ] }, "reaction_10552610": { "compartment": "compartment_876", "id": "reaction_10552610", "reactome": "R-CEL-5607746", "name": "PKC-delta is activated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10552599" ], "products": [ "species_10552608" ], "modifiers": [], "additional_components": [ "species_112275", "P34722", "WBGene00006599", "species_112275", "P34722", "WBGene00006599" ] }, "reaction_10552614": { "compartment": "compartment_876", "id": "reaction_10552614", "reactome": "R-CEL-5607755", "name": "p-Y753,Y759-PLCG2 translocates from cytosol to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10552612" ], "products": [ "species_10552603" ], "modifiers": [], "additional_components": [ "WBGene00004038", "WBGene00004038" ] }, "reaction_10552601": { "compartment": "compartment_876", "id": "reaction_10552601", "reactome": "R-CEL-5607734", "name": "PKC-delta translocates to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10550601", "species_112275" ], "products": [ "species_10552599" ], "modifiers": [], "additional_components": [ "WBGene00006599", "species_112275", "P34722", "WBGene00006599" ] }, "reaction_10552606": { "compartment": "compartment_876", "id": "reaction_10552606", "reactome": "R-CEL-5607735", "name": "p-Y753,Y759-PLCG2 hydrolyses PIP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_179856" ], "products": [ "species_114520", "species_112275" ], "modifiers": [ [ "species_10552603", "catalyst" ] ], "additional_components": [ "WBGene00004038" ] }, "reaction_10553376": { "compartment": "compartment_876", "id": "reaction_10553376", "reactome": "R-CEL-5624486", "name": "SFKs phosphorylates RAF1 on Y340,Y341", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10553365" ], "products": [ "species_10553371", "species_29370" ], "modifiers": [ [ "species_10553373", "catalyst" ] ], "additional_components": [ "Q07292", "WBGene00003030", "species_29438", "P22981", "WBGene00002335", "Q07292", "WBGene00003030", "species_29438", "P22981", "WBGene00002335", "Q9N3S5", "WBGene00021635", "G5EE56", "WBGene00005077" ] }, "reaction_10553381": { "compartment": "compartment_876", "id": "reaction_10553381", "reactome": "R-CEL-5624492", "name": "PAK phosphorylates p21 RAF1 on S338", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10553378" ], "products": [ "species_29370", "species_10553365" ], "modifiers": [ [ "species_10520688", "catalyst" ] ], "additional_components": [ "species_29438", "P22981", "WBGene00002335", "Q07292", "WBGene00003030", "Q07292", "WBGene00003030", "species_29438", "P22981", "WBGene00002335", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911" ] }, "reaction_10553383": { "compartment": "compartment_876", "id": "reaction_10553383", "reactome": "R-CEL-5624494", "name": "RAF1 binds p21 RAS:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10521086", "species_10511481" ], "products": [ "species_10553378" ], "modifiers": [], "additional_components": [ "WBGene00003030", "species_29438", "P22981", "WBGene00002335", "species_29438", "P22981", "WBGene00002335", "Q07292", "WBGene00003030" ] }, "reaction_10565907": { "compartment": "compartment_984", "id": "reaction_10565907", "reactome": "R-CEL-8862771", "name": "PLA2G2A binds bacterial phospholipids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10535794", "species_8931784" ], "products": [ "species_10565905" ], "modifiers": [], "additional_components": [ "O16654", "WBGene00044468", "Q17790", "WBGene00044468", "Q3V5J7", "WBGene00044468", "species_74016", "CHEBI:62643", "CHEBI:62643", "O16654", "WBGene00044468", "Q17790", "WBGene00044468", "Q3V5J7", "WBGene00044468", "species_74016" ] }, "reaction_10562932": { "compartment": "compartment_984", "id": "reaction_10562932", "reactome": "R-CEL-6801762", "name": "REG3A oligomerize to form a pore complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10562926" ], "products": [ "species_10562930" ], "modifiers": [ [ "species_166005", "inhibitor" ] ], "additional_components": [ "CHEBI:62643", "G4RY15", "WBGene00015631", "P34472", "WBGene00010228", "Q22591", "WBGene00020585", "CHEBI:62643", "G4RY15", "WBGene00015631", "P34472", "WBGene00010228", "Q22591", "WBGene00020585" ] }, "reaction_10562950": { "compartment": "compartment_984", "id": "reaction_10562950", "reactome": "R-CEL-6801776", "name": "REG3A binds bacterial phospholipids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10562924", "species_8931784" ], "products": [ "species_10562926" ], "modifiers": [], "additional_components": [ "G4RY15", "WBGene00015631", "P34472", "WBGene00010228", "Q22591", "WBGene00020585", "CHEBI:62643", "CHEBI:62643", "G4RY15", "WBGene00015631", "P34472", "WBGene00010228", "Q22591", "WBGene00020585" ] }, "reaction_10563816": { "compartment": "compartment_984", "id": "reaction_10563816", "reactome": "R-CEL-6810724", "name": "PI3 binds the bacterial surface", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6803081", "species_10563812" ], "products": [ "species_10563814" ], "modifiers": [], "additional_components": [ "O44131", "WBGene00015620", "O44131", "WBGene00015620", "species_166005" ] }, "reaction_10562954": { "compartment": "compartment_984", "id": "reaction_10562954", "reactome": "R-CEL-6801808", "name": "REG3A,REG3G binds bacterial peptidoglycan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10562924", "species_6789198" ], "products": [ "species_10562952" ], "modifiers": [], "additional_components": [ "G4RY15", "WBGene00015631", "P34472", "WBGene00010228", "Q22591", "WBGene00020585", "species_6789198", "G4RY15", "WBGene00015631", "P34472", "WBGene00010228", "Q22591", "WBGene00020585" ] }, "reaction_10563166": { "compartment": "compartment_984", "id": "reaction_10563166", "reactome": "R-CEL-6807585", "name": "BPI binds LPS on the bacterial surface", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6803081", "species_10510721" ], "products": [ "species_10563164" ], "modifiers": [], "additional_components": [ "WBGene00020563", "Q10011", "WBGene00020563", "species_166005" ] }, "reaction_10532731": { "compartment": "compartment_876", "id": "reaction_10532731", "reactome": "R-CEL-1296039", "name": "Activation of Ca2+ activated Potassium channels with small conductance", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10532728", "catalyst" ] ], "additional_components": [ "Q11122", "WBGene00015387", "V6CLK4", "WBGene00008570", "G5EFI1", "WBGene00007176", "O17697", "WBGene00008265" ] }, "reaction_10532702": { "compartment": "compartment_876", "id": "reaction_10532702", "reactome": "R-CEL-1296035", "name": "Activation of Ca2+ activated Potassium channels with Intermediate conductance", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10532699", "catalyst" ] ], "additional_components": [ "Q11122", "WBGene00015387", "V6CLK4", "WBGene00008570", "G5EFI1", "WBGene00007176", "O17697", "WBGene00008265" ] }, "reaction_10513650": { "compartment": "compartment_876", "id": "reaction_10513650", "reactome": "R-CEL-196017", "name": "Dynamin is recruited to the gap junction plaque", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10512940", "species_10512931" ], "products": [ "species_10512942" ], "modifiers": [], "additional_components": [ "A0A486WXX8", "WBGene00000894", "P35603", "WBGene00001082", "A0A486WXX8", "WBGene00000894", "P35603", "WBGene00001082" ] }, "reaction_10513652": { "compartment": "compartment_876", "id": "reaction_10513652", "reactome": "R-CEL-196026", "name": "Dab2 is recruited to the junctional plaques", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10512924", "species_10512929" ], "products": [ "species_10512931" ], "modifiers": [], "additional_components": [ "P35603", "WBGene00001082", "WBGene00000894", "A0A486WXX8", "WBGene00000894", "P35603", "WBGene00001082" ] }, "reaction_10524969": { "compartment": "compartment_876", "id": "reaction_10524969", "reactome": "R-CEL-445714", "name": "Aquaporin-3 passively transports water out of cell", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356" ], "products": [ "species_109276" ], "modifiers": [ [ "species_10524966", "catalyst" ] ], "additional_components": [ "Q7Z138", "WBGene00000176", "Q9XW36", "WBGene00000171", "Q17571", "WBGene00000170", "Q19949", "WBGene00000169", "Q21473", "WBGene00000175", "Q7YWQ1", "WBGene00013272" ] }, "reaction_10527170": { "compartment": "compartment_876", "id": "reaction_10527170", "reactome": "R-CEL-507869", "name": "Aquaporins passively transport glycerol into cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_192438" ], "products": [ "species_76116" ], "modifiers": [ [ "species_10527167", "catalyst" ] ], "additional_components": [ "Q7YWQ1", "WBGene00013272", "Q17571", "WBGene00000170", "Q7Z138", "WBGene00000176", "Q19949", "WBGene00000169", "Q9XW36", "WBGene00000171", "Q21473", "WBGene00000175" ] }, "reaction_10527172": { "compartment": "compartment_876", "id": "reaction_10527172", "reactome": "R-CEL-507870", "name": "Aquaporins passively transport water out of cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356" ], "products": [ "species_109276" ], "modifiers": [ [ "species_10527162", "catalyst" ] ], "additional_components": [ "Q7YWQ1", "WBGene00013272", "Q17571", "WBGene00000170", "Q7Z138", "WBGene00000176", "Q19949", "WBGene00000169", "Q9XW36", "WBGene00000171", "Q21473", "WBGene00000175", "G5EEK0", "WBGene00000172" ] }, "reaction_10527174": { "compartment": "compartment_876", "id": "reaction_10527174", "reactome": "R-CEL-507871", "name": "Aquaporins passively transport glycerol out of cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76116" ], "products": [ "species_192438" ], "modifiers": [ [ "species_10527167", "catalyst" ] ], "additional_components": [ "Q7YWQ1", "WBGene00013272", "Q17571", "WBGene00000170", "Q7Z138", "WBGene00000176", "Q19949", "WBGene00000169", "Q9XW36", "WBGene00000171", "Q21473", "WBGene00000175" ] }, "reaction_10527179": { "compartment": "compartment_876", "id": "reaction_10527179", "reactome": "R-CEL-507873", "name": "Aquaporins passively transport urea out of cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29514" ], "products": [ "species_432019" ], "modifiers": [ [ "species_10527176", "catalyst" ] ], "additional_components": [ "Q7YWQ1", "WBGene00013272", "Q17571", "WBGene00000170", "Q7Z138", "WBGene00000176", "Q19949", "WBGene00000169", "Q9XW36", "WBGene00000171", "Q21473", "WBGene00000175" ] }, "reaction_10527165": { "compartment": "compartment_876", "id": "reaction_10527165", "reactome": "R-CEL-507868", "name": "Aquaporins passively transport water into cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276" ], "products": [ "species_29356" ], "modifiers": [ [ "species_10527162", "catalyst" ] ], "additional_components": [ "Q7YWQ1", "WBGene00013272", "Q17571", "WBGene00000170", "Q7Z138", "WBGene00000176", "Q19949", "WBGene00000169", "Q9XW36", "WBGene00000171", "Q21473", "WBGene00000175", "G5EEK0", "WBGene00000172" ] }, "reaction_10527181": { "compartment": "compartment_876", "id": "reaction_10527181", "reactome": "R-CEL-507875", "name": "Aquaporins passively transport urea into cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_432019" ], "products": [ "species_29514" ], "modifiers": [ [ "species_10527176", "catalyst" ] ], "additional_components": [ "Q7YWQ1", "WBGene00013272", "Q17571", "WBGene00000170", "Q7Z138", "WBGene00000176", "Q19949", "WBGene00000169", "Q9XW36", "WBGene00000171", "Q21473", "WBGene00000175" ] }, "reaction_10551505": { "compartment": "compartment_70101", "id": "reaction_10551505", "reactome": "R-CEL-5340214", "name": "CYGB binds O2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10551501", "species_29368" ], "products": [ "species_10551503" ], "modifiers": [], "additional_components": [ "species_71185", "O17824", "WBGene00008996", "species_113534", "species_71185", "O17824", "WBGene00008996" ] }, "reaction_10570320": { "compartment": "compartment_70101", "id": "reaction_10570320", "reactome": "R-CEL-8981621", "name": "Neuroglobin:oxygen dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10570316" ], "products": [ "species_10570314", "species_29368" ], "modifiers": [], "additional_components": [ "species_113534", "species_71185", "Q7YZV1", "WBGene00016024", "species_71185", "Q7YZV1", "WBGene00016024" ] }, "reaction_10570501": { "compartment": "compartment_70101", "id": "reaction_10570501", "reactome": "R-CEL-8982617", "name": "CYGB:O2 dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10551503" ], "products": [ "species_10551501", "species_29368" ], "modifiers": [], "additional_components": [ "species_113534", "species_71185", "O17824", "WBGene00008996", "species_71185", "O17824", "WBGene00008996" ] }, "reaction_10570318": { "compartment": "compartment_70101", "id": "reaction_10570318", "reactome": "R-CEL-8981610", "name": "Neuroglobin binds oxygen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10570314", "species_29368" ], "products": [ "species_10570316" ], "modifiers": [], "additional_components": [ "species_71185", "Q7YZV1", "WBGene00016024", "species_113534", "species_71185", "Q7YZV1", "WBGene00016024" ] }, "reaction_10522434": { "compartment": "compartment_876", "id": "reaction_10522434", "reactome": "R-CEL-425483", "name": "SLC4A5,7,9 cotransport Na+ with 3HCO3-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111627", "species_83910" ], "products": [ "species_425425", "species_74113" ], "modifiers": [ [ "species_10522431", "catalyst" ] ], "additional_components": [ "B3WFV9", "WBGene00009920", "Q58QG8", "WBGene00019844" ] }, "reaction_10567850": { "compartment": "compartment_876", "id": "reaction_10567850", "reactome": "R-CEL-8878664", "name": "SLC4A4 cotransports Na+ with 3HCO3-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111627", "species_83910" ], "products": [ "species_425425", "species_74113" ], "modifiers": [ [ "species_10567847", "catalyst" ] ], "additional_components": [ "B3WFV9", "WBGene00009920", "Q58QG8", "WBGene00019844" ] }, "reaction_10522447": { "compartment": "compartment_876", "id": "reaction_10522447", "reactome": "R-CEL-425577", "name": "Na+-driven Cl-/HCO3- exchanger transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_425425", "species_352022", "species_74113" ], "products": [ "species_351626", "species_188972", "species_111627", "species_83910" ], "modifiers": [ [ "species_10522444", "catalyst" ] ], "additional_components": [ "B3WFV9", "WBGene00009920", "Q58QG8", "WBGene00019844" ] }, "reaction_10555169": { "compartment": "compartment_7660", "id": "reaction_10555169", "reactome": "R-CEL-5674387", "name": "Phosphorylated MAPKs translocate into the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10555165" ], "products": [ "species_10555167" ], "modifiers": [], "additional_components": [ "P39745", "WBGene00003401", "P39745", "WBGene00003401" ] }, "reaction_10555224": { "compartment": "compartment_70101", "id": "reaction_10555224", "reactome": "R-CEL-5675376", "name": "Cytosolic DUSPs dephosphorylate MAPKs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10555165", "species_29356" ], "products": [ "species_29372", "species_10555201" ], "modifiers": [ [ "species_10555221", "catalyst" ] ], "additional_components": [ "P39745", "WBGene00003401", "P39745", "WBGene00003401", "Q9XUJ0", "WBGene00012372" ] }, "reaction_10508594": { "compartment": "compartment_70101", "id": "reaction_10508594", "reactome": "R-CEL-109860", "name": "MAP2K1 phosphorylates MAPK3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10508567" ], "products": [ "species_29370", "species_10508585" ], "modifiers": [ [ "species_10508567", "catalyst" ], [ "species_10508590", "inhibitor" ] ], "additional_components": [ "Q10664", "WBGene00003186", "P39745", "WBGene00003401", "Q10664", "WBGene00003186", "P39745", "WBGene00003401", "Q10664", "WBGene00003186", "P39745", "WBGene00003401", "WBGene00003186" ] }, "reaction_10508569": { "compartment": "compartment_70101", "id": "reaction_10508569", "reactome": "R-CEL-109857", "name": "MAP2K1 binds MAPK3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508565", "species_10508560" ], "products": [ "species_10508567" ], "modifiers": [], "additional_components": [ "WBGene00003401", "WBGene00003186", "Q10664", "WBGene00003186", "P39745", "WBGene00003401" ] }, "reaction_10509182": { "compartment": "compartment_70101", "id": "reaction_10509182", "reactome": "R-CEL-112342", "name": "Inactivation of MAP2K1 by CDK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10509173" ], "products": [ "species_10508590", "species_29370" ], "modifiers": [ [ "species_10509179", "catalyst" ] ], "additional_components": [ "Q10664", "WBGene00003186", "WBGene00003186", "WBGene00000405" ] }, "reaction_10508606": { "compartment": "compartment_70101", "id": "reaction_10508606", "reactome": "R-CEL-109863", "name": "Dissociation of p-T,Y-MAPK3:MAP2K1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508585" ], "products": [ "species_10508583", "species_10508560" ], "modifiers": [], "additional_components": [ "Q10664", "WBGene00003186", "P39745", "WBGene00003401", "WBGene00003401", "WBGene00003186" ] }, "reaction_10570242": { "compartment": "compartment_7660", "id": "reaction_10570242", "reactome": "R-CEL-8979071", "name": "KDM6B binds iron", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546680", "species_111793" ], "products": [ "species_10546682" ], "modifiers": [], "additional_components": [ "Q19760", "WBGene00009089", "Q95QK3", "WBGene00017571", "species_113531", "Q19760", "WBGene00009089", "Q95QK3", "WBGene00017571" ] }, "reaction_10546756": { "compartment": "compartment_7660", "id": "reaction_10546756", "reactome": "R-CEL-3240295", "name": "PRC2-EZH2 trimethylates nucleosomes associated with CDKN2A promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10546668" ], "products": [ "species_77502", "species_10546666" ], "modifiers": [ [ "species_10517100", "catalyst" ] ], "additional_components": [ "P62784", "WBGene00001875", "K7ZUH9", "WBGene00001914", "Q10453", "WBGene00001945", "P62784", "WBGene00001875", "Q10453", "WBGene00001945", "K7ZUH9", "WBGene00001914", "Q9GYS1", "WBGene00003224", "O17514", "WBGene00003220", "P90916", "WBGene00003036", "P90917", "WBGene00004312" ] }, "reaction_10546703": { "compartment": "compartment_70101", "id": "reaction_10546703", "reactome": "R-CEL-3225851", "name": "ROS oxidize thioredoxin and activate MAP3K5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546692", "species_1250243" ], "products": [ "species_10506158", "species_10546690" ], "modifiers": [ [ "species_10546697", "catalyst" ] ], "additional_components": [ "Q09433", "WBGene00015062", "Q21029", "WBGene00003822", "WBGene00015062", "WBGene00003822", "WBGene00003247" ] }, "reaction_10546707": { "compartment": "compartment_70101", "id": "reaction_10546707", "reactome": "R-CEL-3228469", "name": "MAP3K5 phosphorylates MKK3 and MKK6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10525576" ], "products": [ "species_29370", "species_10525521" ], "modifiers": [ [ "species_10546690", "catalyst" ] ], "additional_components": [ "Q58AU7", "WBGene00018034", "Q58AU8", "WBGene00018035", "G5EDF7", "WBGene00004758", "Q58AU7", "WBGene00018034", "Q58AU8", "WBGene00018035", "G5EDF7", "WBGene00004758", "WBGene00003822" ] }, "reaction_10546685": { "compartment": "compartment_7660", "id": "reaction_10546685", "reactome": "R-CEL-3222593", "name": "KDM6B demethylates H3K27me3 on p16INK4A promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546666", "species_113671" ], "products": [ "species_10546668", "species_159939" ], "modifiers": [ [ "species_10546682", "catalyst" ] ], "additional_components": [ "P62784", "WBGene00001875", "Q10453", "WBGene00001945", "K7ZUH9", "WBGene00001914", "P62784", "WBGene00001875", "K7ZUH9", "WBGene00001914", "Q10453", "WBGene00001945", "species_113531", "Q19760", "WBGene00009089", "Q95QK3", "WBGene00017571" ] }, "reaction_10524560": { "compartment": "compartment_70101", "id": "reaction_10524560", "reactome": "R-CEL-443831", "name": "14-3-3-zeta binds Raf1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10521086", "species_10507059" ], "products": [ "species_10524558" ], "modifiers": [], "additional_components": [ "WBGene00003030", "Q20655", "WBGene00001502", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "P41932", "WBGene00003920", "Q07292", "WBGene00003030" ] }, "reaction_10524541": { "compartment": "compartment_70101", "id": "reaction_10524541", "reactome": "R-CEL-443439", "name": "c-Src binds Raf1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10521086", "species_10518252" ], "products": [ "species_10524539" ], "modifiers": [], "additional_components": [ "WBGene00003030", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q07292", "WBGene00003030" ] }, "reaction_10516411": { "compartment": "compartment_70101", "id": "reaction_10516411", "reactome": "R-CEL-209828", "name": "Tryptophan is hydroxylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29870", "species_29500", "species_29368" ], "products": [ "species_71112", "species_209911" ], "modifiers": [ [ "species_10516408", "catalyst" ] ], "additional_components": [ "G5EED8", "WBGene00006600", "species_113531" ] }, "reaction_10516429": { "compartment": "compartment_70101", "id": "reaction_10516429", "reactome": "R-CEL-209859", "name": "Decarboxylation of 5-hydroxytryptophan forms serotonin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_209911" ], "products": [ "species_113528", "species_209914" ], "modifiers": [ [ "species_10516426", "catalyst" ] ], "additional_components": [ "O45137", "WBGene00000239" ] }, "reaction_10533009": { "compartment": "compartment_7660", "id": "reaction_10533009", "reactome": "R-CEL-1362270", "name": "Phosphorylation of LIN52 component of MuvB by DYRK1A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10533001" ], "products": [ "species_113582", "species_10532993" ], "modifiers": [ [ "species_10533006", "catalyst" ] ], "additional_components": [ "P90916", "WBGene00003036", "Q95QD7", "WBGene00003037", "Q10120", "WBGene00003035", "P30630", "WBGene00002998", "Q23482", "WBGene00003022", "P90916", "WBGene00003036", "Q95QD7", "WBGene00003037", "P30630", "WBGene00002998", "Q23482", "WBGene00003022", "Q10120", "WBGene00003035", "WBGene00003149" ] }, "reaction_10533091": { "compartment": "compartment_7660", "id": "reaction_10533091", "reactome": "R-CEL-1363314", "name": "p107 (RBL1) binds CyclinE/A:CDK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10532106", "species_10533075" ], "products": [ "species_10533089" ], "modifiers": [], "additional_components": [ "WBGene00003020", "O61847", "WBGene00019362", "O61847", "WBGene00019362", "G5EDT1", "WBGene00003020" ] }, "reaction_10532997": { "compartment": "compartment_7660", "id": "reaction_10532997", "reactome": "R-CEL-1362261", "name": "p130 (RBL2) associates with MuvB to form DREAM complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10532993", "species_10532097" ], "products": [ "species_10532995" ], "modifiers": [], "additional_components": [ "P90916", "WBGene00003036", "Q95QD7", "WBGene00003037", "P30630", "WBGene00002998", "Q23482", "WBGene00003022", "Q10120", "WBGene00003035", "G5EDT1", "WBGene00003020", "G5EF11", "WBGene00001161", "Q22703", "WBGene00001061", "G5EDT1", "WBGene00003020", "G5EF11", "WBGene00001161", "Q22703", "WBGene00001061", "P90916", "WBGene00003036", "Q95QD7", "WBGene00003037", "P30630", "WBGene00002998", "Q23482", "WBGene00003022", "Q10120", "WBGene00003035" ] }, "reaction_10533079": { "compartment": "compartment_7660", "id": "reaction_10533079", "reactome": "R-CEL-1363303", "name": "p130 (RBL2) in complex with E2F4/5:DP1/2 binds to cyclin E/A:CDK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10533075", "species_10532097" ], "products": [ "species_10533077" ], "modifiers": [], "additional_components": [ "O61847", "WBGene00019362", "G5EDT1", "WBGene00003020", "G5EF11", "WBGene00001161", "Q22703", "WBGene00001061", "G5EDT1", "WBGene00003020", "G5EF11", "WBGene00001161", "Q22703", "WBGene00001061", "O61847", "WBGene00019362" ] }, "reaction_10532123": { "compartment": "compartment_7660", "id": "reaction_10532123", "reactome": "R-CEL-1227670", "name": "Recruitment of HDAC1 by p130 (RBL2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10532119", "species_10532097" ], "products": [ "species_10532121" ], "modifiers": [], "additional_components": [ "WBGene00001836", "G5EDT1", "WBGene00003020", "G5EF11", "WBGene00001161", "Q22703", "WBGene00001061", "G5EDT1", "WBGene00003020", "G5EF11", "WBGene00001161", "Q22703", "WBGene00001061", "G5ECH0", "WBGene00001836" ] }, "reaction_10533083": { "compartment": "compartment_7660", "id": "reaction_10533083", "reactome": "R-CEL-1363306", "name": "p130 (RBL2) binds Cyclin E/A:CDK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10533075", "species_10532081" ], "products": [ "species_10533081" ], "modifiers": [], "additional_components": [ "O61847", "WBGene00019362", "WBGene00003020", "G5EDT1", "WBGene00003020", "O61847", "WBGene00019362" ] }, "reaction_10532127": { "compartment": "compartment_7660", "id": "reaction_10532127", "reactome": "R-CEL-1227671", "name": "Recruitment of HDAC1 by p107 (RBL1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10532108", "species_10532119" ], "products": [ "species_10532125" ], "modifiers": [], "additional_components": [ "G5EF11", "WBGene00001161", "G5EDT1", "WBGene00003020", "Q22703", "WBGene00001061", "WBGene00001836", "G5ECH0", "WBGene00001836", "G5EF11", "WBGene00001161", "G5EDT1", "WBGene00003020", "Q22703", "WBGene00001061" ] }, "reaction_10533087": { "compartment": "compartment_7660", "id": "reaction_10533087", "reactome": "R-CEL-1363311", "name": "p107 (RBL1) in complex with E2F4:DP1/2 binds to cyclin E/A:CDK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10532108", "species_10533075" ], "products": [ "species_10533085" ], "modifiers": [], "additional_components": [ "G5EF11", "WBGene00001161", "G5EDT1", "WBGene00003020", "Q22703", "WBGene00001061", "O61847", "WBGene00019362", "O61847", "WBGene00019362", "G5EF11", "WBGene00001161", "G5EDT1", "WBGene00003020", "Q22703", "WBGene00001061" ] }, "reaction_10509407": { "compartment": "compartment_7660", "id": "reaction_10509407", "reactome": "R-CEL-113504", "name": "Detection of damage during initiation of DNA synthesis in S-phase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502577" ], "products": [ "species_10502123", "species_113656" ], "modifiers": [], "additional_components": [ "C7IVS4", "WBGene00012936", "P34471", "WBGene00004180", "O02334", "WBGene00004181", "Q21625", "WBGene00001002", "C7IVS4", "WBGene00012936", "P34471", "WBGene00004180", "O02334", "WBGene00004181", "Q21625", "WBGene00001002" ] }, "reaction_10502244": { "compartment": "compartment_7660", "id": "reaction_10502244", "reactome": "R-CEL-68919", "name": "Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502184", "species_10502240" ], "products": [ "species_10502242" ], "modifiers": [], "additional_components": [ "WBGene00012935", "O16297", "WBGene00003159", "Q95XQ8", "WBGene00003156", "Q9XXI9", "WBGene00003154", "Q21902", "WBGene00003157", "P34647", "WBGene00003158", "Q9XVR7", "WBGene00003155", "Q9XX16", "WBGene00012651", "Q23249", "WBGene00013857", "Q9XX17", "WBGene00012650", "Q21037", "WBGene00003882", "P91155", "WBGene00000382", "Q86S68", "WBGene00000413", "O16297", "WBGene00003159", "Q95XQ8", "WBGene00003156", "Q9XXI9", "WBGene00003154", "Q21902", "WBGene00003157", "P34647", "WBGene00003158", "Q9XVR7", "WBGene00003155", "Q9XX16", "WBGene00012651", "Q23249", "WBGene00013857", "Q9XX17", "WBGene00012650", "Q21037", "WBGene00003882", "P91155", "WBGene00000382", "Q86S68", "WBGene00000413", "Q9U2C2", "WBGene00012935" ] }, "reaction_10502246": { "compartment": "compartment_7660", "id": "reaction_10502246", "reactome": "R-CEL-68940", "name": "Cdt1 is displaced from the pre-replicative complex.", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502242" ], "products": [ "species_10502230", "species_10502099" ], "modifiers": [], "additional_components": [ "O16297", "WBGene00003159", "Q95XQ8", "WBGene00003156", "Q9XXI9", "WBGene00003154", "Q21902", "WBGene00003157", "P34647", "WBGene00003158", "Q9XVR7", "WBGene00003155", "Q9XX16", "WBGene00012651", "Q23249", "WBGene00013857", "Q9XX17", "WBGene00012650", "Q21037", "WBGene00003882", "P91155", "WBGene00000382", "Q86S68", "WBGene00000413", "Q9U2C2", "WBGene00012935", "Q9XX16", "WBGene00012651", "Q23249", "WBGene00013857", "Q9XX17", "WBGene00012650", "Q21037", "WBGene00003882", "P91155", "WBGene00000382", "O16297", "WBGene00003159", "Q95XQ8", "WBGene00003156", "Q9XXI9", "WBGene00003154", "Q21902", "WBGene00003157", "P34647", "WBGene00003158", "Q9XVR7", "WBGene00003155", "Q9U2C2", "WBGene00012935", "WBGene00000413" ] }, "reaction_10502584": { "compartment": "compartment_7660", "id": "reaction_10502584", "reactome": "R-CEL-68960", "name": "DNA polymerase epsilon binds at the origin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_68419", "species_10502145" ], "products": [ "species_10502147" ], "modifiers": [], "additional_components": [ "O62218", "WBGene00009368", "Q19196", "WBGene00017237", "Q22798", "WBGene00020823", "Q9NAC5", "WBGene00013150", "O62218", "WBGene00009368", "Q19196", "WBGene00017237", "Q22798", "WBGene00020823", "Q9NAC5", "WBGene00013150" ] }, "reaction_10502236": { "compartment": "compartment_7660", "id": "reaction_10502236", "reactome": "R-CEL-68917", "name": "Cdc45 associates with the pre-replicative complex at the origin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502232", "species_10502161" ], "products": [ "species_10502234" ], "modifiers": [], "additional_components": [ "O01493", "WBGene00016421", "Q9XX16", "WBGene00012651", "Q23249", "WBGene00013857", "Q9XX17", "WBGene00012650", "Q21037", "WBGene00003882", "P91155", "WBGene00000382", "O16297", "WBGene00003159", "Q95XQ8", "WBGene00003156", "Q9XXI9", "WBGene00003154", "Q21902", "WBGene00003157", "P34647", "WBGene00003158", "Q9XVR7", "WBGene00003155", "Q9U2C2", "WBGene00012935", "O61847", "WBGene00019362", "WBGene00009372", "Q7JMR0", "WBGene00009372", "O01493", "WBGene00016421", "Q9XX16", "WBGene00012651", "Q23249", "WBGene00013857", "Q9XX17", "WBGene00012650", "Q21037", "WBGene00003882", "P91155", "WBGene00000382", "O16297", "WBGene00003159", "Q95XQ8", "WBGene00003156", "Q9XXI9", "WBGene00003154", "Q21902", "WBGene00003157", "P34647", "WBGene00003158", "Q9XVR7", "WBGene00003155", "Q9U2C2", "WBGene00012935", "O61847", "WBGene00019362" ] }, "reaction_10502156": { "compartment": "compartment_7660", "id": "reaction_10502156", "reactome": "R-CEL-68914", "name": "DNA polymerase alpha:primase binds at the origin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502123", "species_10502147" ], "products": [ "species_10502149" ], "modifiers": [], "additional_components": [ "C7IVS4", "WBGene00012936", "P34471", "WBGene00004180", "O02334", "WBGene00004181", "Q21625", "WBGene00001002", "O62218", "WBGene00009368", "Q19196", "WBGene00017237", "Q22798", "WBGene00020823", "Q9NAC5", "WBGene00013150", "O62218", "WBGene00009368", "Q19196", "WBGene00017237", "Q22798", "WBGene00020823", "Q9NAC5", "WBGene00013150", "C7IVS4", "WBGene00012936", "P34471", "WBGene00004180", "O02334", "WBGene00004181", "Q21625", "WBGene00001002" ] }, "reaction_10546046": { "compartment": "compartment_7660", "id": "reaction_10546046", "reactome": "R-CEL-2990840", "name": "SENP1,2,5 proteolytically process SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546014" ], "products": [ "species_10528096" ], "modifiers": [ [ "species_10546043", "catalyst" ] ], "additional_components": [ "WBGene00004888", "WBGene00004888", "O44984", "WBGene00006740", "Q09353", "WBGene00006736", "Q23238", "WBGene00006737" ] }, "reaction_10570130": { "compartment": "compartment_7660", "id": "reaction_10570130", "reactome": "R-CEL-8956365", "name": "ZBED1 (DREF) SUMOylates CHD3 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546081", "species_10548000" ], "products": [ "species_10570122", "species_10546073" ], "modifiers": [ [ "species_10570127", "catalyst" ] ], "additional_components": [ "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "G5EBZ4", "WBGene00002637", "Q22516", "WBGene00000482", "P55853", "WBGene00004888", "G5EBZ4", "WBGene00002637", "Q22516", "WBGene00000482", "WBGene00006706", "WBGene00010704" ] }, "reaction_10549430": { "compartment": "compartment_7660", "id": "reaction_10549430", "reactome": "R-CEL-4616015", "name": "SUMOylation of HDAC2 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10547980", "species_10546081" ], "products": [ "species_10546073", "species_10549428" ], "modifiers": [ [ "species_10546081", "catalyst" ] ], "additional_components": [ "G5ECH0", "WBGene00001836", "Q09440", "WBGene00001835", "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "WBGene00006706", "Q09440", "WBGene00001835", "G5ECH0", "WBGene00001836", "P55853", "WBGene00004888", "Q95017", "WBGene00006706", "P55853", "WBGene00004888" ] }, "reaction_10549306": { "compartment": "compartment_7660", "id": "reaction_10549306", "reactome": "R-CEL-4570496", "name": "SUMOylation of Histone H4 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546081", "species_10506929" ], "products": [ "species_10546073", "species_10549304" ], "modifiers": [ [ "species_10546081", "catalyst" ] ], "additional_components": [ "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "WBGene00001875", "WBGene00006706", "P55853", "WBGene00004888", "P62784", "WBGene00001875", "Q95017", "WBGene00006706", "P55853", "WBGene00004888" ] }, "reaction_10549403": { "compartment": "compartment_7660", "id": "reaction_10549403", "reactome": "R-CEL-4615905", "name": "PIAS1 SUMOylates SATB1 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546081", "species_10518112" ], "products": [ "species_10546073", "species_10549401" ], "modifiers": [ [ "species_10528091", "catalyst" ] ], "additional_components": [ "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "WBGene00022861", "WBGene00006706", "P55853", "WBGene00004888", "Q86MI0", "WBGene00022861", "Q21970", "WBGene00011259", "Q94361", "WBGene00001574" ] }, "reaction_10549391": { "compartment": "compartment_7660", "id": "reaction_10549391", "reactome": "R-CEL-4615889", "name": "SUMOylation of HDAC1 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10532119", "species_10546081" ], "products": [ "species_10549389", "species_10546073" ], "modifiers": [ [ "species_10546081", "catalyst" ] ], "additional_components": [ "WBGene00001836", "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "P55853", "WBGene00004888", "G5ECH0", "WBGene00001836", "WBGene00006706", "Q95017", "WBGene00006706", "P55853", "WBGene00004888" ] }, "reaction_10508432": { "compartment": "compartment_70101", "id": "reaction_10508432", "reactome": "R-CEL-109539", "name": "Concentrative transport (import) of nucleosides plus sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179740", "species_74113" ], "products": [ "species_179741", "species_83910" ], "modifiers": [ [ "species_10508429", "catalyst" ] ], "additional_components": [ "species_83927", "CHEBI:16750", "CHEBI:16704", "species_83909", "species_83909", "species_83927", "CHEBI:16750", "CHEBI:16704", "WBGene00017867" ] }, "reaction_10508417": { "compartment": "compartment_70101", "id": "reaction_10508417", "reactome": "R-CEL-109530", "name": "Concentrative transport (import) of a nucleoside and a sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179738", "species_74113" ], "products": [ "species_179739", "species_83910" ], "modifiers": [ [ "species_10508414", "catalyst" ] ], "additional_components": [ "CHEBI:16704", "species_83928", "species_83909", "CHEBI:17562", "CHEBI:17256", "CHEBI:17256", "species_83909", "CHEBI:16704", "species_83928", "CHEBI:17562", "WBGene00017867" ] }, "reaction_10508420": { "compartment": "compartment_70101", "id": "reaction_10508420", "reactome": "R-CEL-109534", "name": "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179743" ], "products": [ "species_179737" ], "modifiers": [ [ "species_10508404", "catalyst" ] ], "additional_components": [ "species_83909", "species_83927", "CHEBI:16750", "CHEBI:16704", "species_83928", "CHEBI:17562", "species_83927", "CHEBI:16750", "CHEBI:16704", "species_83928", "species_83909", "CHEBI:17562", "WBGene00009499" ] }, "reaction_10527797": { "compartment": "compartment_70101", "id": "reaction_10527797", "reactome": "R-CEL-727749", "name": "SLC29A3 transports nucleosides from lysosomal lumen to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_727782" ], "products": [ "species_727746" ], "modifiers": [ [ "species_10527794", "catalyst" ] ], "additional_components": [ "species_83909", "species_83927", "CHEBI:16704", "CHEBI:16750", "CHEBI:17562", "species_83928", "species_83951", "species_83909", "species_83927", "CHEBI:16750", "CHEBI:16704", "species_83928", "CHEBI:17562", "species_83951", "WBGene00009499" ] }, "reaction_10508422": { "compartment": "compartment_70101", "id": "reaction_10508422", "reactome": "R-CEL-109536", "name": "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179737" ], "products": [ "species_179743" ], "modifiers": [ [ "species_10508404", "catalyst" ] ], "additional_components": [ "species_83927", "CHEBI:16750", "CHEBI:16704", "species_83928", "species_83909", "CHEBI:17562", "species_83909", "species_83927", "CHEBI:16750", "CHEBI:16704", "species_83928", "CHEBI:17562", "WBGene00009499" ] }, "reaction_10508407": { "compartment": "compartment_70101", "id": "reaction_10508407", "reactome": "R-CEL-109527", "name": "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179747" ], "products": [ "species_179742" ], "modifiers": [ [ "species_10508402", "catalyst" ] ], "additional_components": [ "species_83927", "CHEBI:16750", "species_83956", "CHEBI:16704", "species_83928", "species_113599", "species_83909", "species_83960", "species_83962", "species_83951", "CHEBI:17562", "CHEBI:16040", "species_83909", "CHEBI:16040", "species_83956", "species_83927", "CHEBI:16750", "CHEBI:16704", "species_83928", "species_83960", "species_83962", "CHEBI:17562", "species_83951", "species_113599", "WBGene00009499" ] }, "reaction_10508409": { "compartment": "compartment_70101", "id": "reaction_10508409", "reactome": "R-CEL-109529", "name": "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179742" ], "products": [ "species_179747" ], "modifiers": [ [ "species_10508402", "catalyst" ] ], "additional_components": [ "species_83909", "CHEBI:16040", "species_83956", "species_83927", "CHEBI:16750", "CHEBI:16704", "species_83928", "species_83960", "species_83962", "CHEBI:17562", "species_83951", "species_113599", "species_83927", "CHEBI:16750", "species_83956", "CHEBI:16704", "species_83928", "species_113599", "species_83909", "species_83960", "species_83962", "species_83951", "CHEBI:17562", "CHEBI:16040", "WBGene00009499" ] }, "reaction_10510169": { "compartment": "compartment_70616", "id": "reaction_10510169", "reactome": "R-CEL-163215", "name": "SLC25A5,6 dimers exchange ATP for ADP across the mitochondrial inner membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29370", "species_113593" ], "products": [ "species_113581", "species_113592" ], "modifiers": [ [ "species_10510166", "catalyst" ] ], "additional_components": [ "P91270", "WBGene00017770" ] }, "reaction_10508427": { "compartment": "compartment_70101", "id": "reaction_10508427", "reactome": "R-CEL-109538", "name": "Concentrative transport (import) of a nucleoside and two sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179737", "species_74113" ], "products": [ "species_179743", "species_83910" ], "modifiers": [ [ "species_10508424", "catalyst" ] ], "additional_components": [ "species_83927", "CHEBI:16750", "CHEBI:16704", "species_83928", "species_83909", "CHEBI:17562", "species_83909", "species_83927", "CHEBI:16750", "CHEBI:16704", "species_83928", "CHEBI:17562", "WBGene00017867" ] }, "reaction_10528229": { "compartment": "compartment_876", "id": "reaction_10528229", "reactome": "R-CEL-879585", "name": "SLC27A1,4,6 transport LCFAs from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_879559" ], "products": [ "species_879544" ], "modifiers": [ [ "species_10528226", "catalyst" ] ], "additional_components": [ "CHEBI:16196", "CHEBI:16196", "Q18916", "WBGene00017012", "Q19878", "WBGene00009218" ] }, "reaction_10527805": { "compartment": "compartment_20699", "id": "reaction_10527805", "reactome": "R-CEL-727759", "name": "SLC33A1 transports Ac-CoA from cytosol to Golgi lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76183" ], "products": [ "species_727753" ], "modifiers": [ [ "species_10527802", "catalyst" ] ], "additional_components": [ "WBGene00012033" ] }, "reaction_10528210": { "compartment": "compartment_876", "id": "reaction_10528210", "reactome": "R-CEL-879575", "name": "SLCOs, SLC16A2 transport T3,T4 from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_879603" ], "products": [ "species_879628" ], "modifiers": [ [ "species_10528207", "catalyst" ] ], "additional_components": [ "species_352326", "species_176667", "species_352326", "species_176667", "Q95ZT3", "WBGene00018568", "O62421", "WBGene00018568", "Q20538", "WBGene00018568", "Q93550", "WBGene00018568", "Q9XWC5", "WBGene00019346", "X5LPS1", "WBGene00019346", "X5LV99", "WBGene00019346" ] }, "reaction_10528168": { "compartment": "compartment_876", "id": "reaction_10528168", "reactome": "R-CEL-879562", "name": "SLCO2B1 has a narrow substrate specificity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_879553" ], "products": [ "species_879654" ], "modifiers": [ [ "species_10528165", "catalyst" ] ], "additional_components": [ "species_176496", "CHEBI:63836", "species_176501", "CHEBI:63836", "species_176501", "species_176496", "Q93550", "WBGene00018568", "Q95ZT3", "WBGene00018568", "O62421", "WBGene00018568", "Q20538", "WBGene00018568" ] }, "reaction_10572296": { "compartment": "compartment_876", "id": "reaction_10572296", "reactome": "R-CEL-9631987", "name": "SLCO1B1 transports T3,T4 from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_879603" ], "products": [ "species_879628" ], "modifiers": [ [ "species_10528178", "catalyst" ] ], "additional_components": [ "species_352326", "species_176667", "species_352326", "species_176667", "Q95ZT3", "WBGene00018568", "O62421", "WBGene00018568", "Q20538", "WBGene00018568", "Q93550", "WBGene00018568" ] }, "reaction_10528234": { "compartment": "compartment_876", "id": "reaction_10528234", "reactome": "R-CEL-879594", "name": "SLCO4C1 mediates the transport of digoxin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_879521" ], "products": [ "species_879517" ], "modifiers": [ [ "species_10528231", "catalyst" ] ], "additional_components": [ "WBGene00019346" ] }, "reaction_10528155": { "compartment": "compartment_876", "id": "reaction_10528155", "reactome": "R-CEL-879528", "name": "SLCO2A1 transports PGT substrates from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_879566" ], "products": [ "species_879614" ], "modifiers": [ [ "species_10528152", "catalyst" ] ], "additional_components": [ "species_879535", "CHEBI:15544", "species_879629", "species_265287", "species_879629", "CHEBI:15544", "species_879535", "species_265287", "Q93550", "WBGene00018568", "Q95ZT3", "WBGene00018568", "O62421", "WBGene00018568", "Q20538", "WBGene00018568" ] }, "reaction_10543903": { "compartment": "compartment_876", "id": "reaction_10543903", "reactome": "R-CEL-2317314", "name": "AKT binds PDPK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10513830", "species_10508530" ], "products": [ "species_10513832" ], "modifiers": [], "additional_components": [ "Q17941", "WBGene00000102", "Q9XTG7", "WBGene00000103", "G4S4W1", "WBGene00016980", "species_179838", "Q9UA62", "WBGene00021022", "species_179838", "Q9UA62", "WBGene00021022", "species_179838", "Q17941", "WBGene00000102", "Q9XTG7", "WBGene00000103", "G4S4W1", "WBGene00016980" ] }, "reaction_10543806": { "compartment": "compartment_70101", "id": "reaction_10543806", "reactome": "R-CEL-2316429", "name": "PIP3 recruits PDPK1 to the membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179838", "species_10515193" ], "products": [ "species_10508530" ], "modifiers": [], "additional_components": [ "WBGene00021022", "Q9UA62", "WBGene00021022", "species_179838" ] }, "reaction_10543581": { "compartment": "compartment_70101", "id": "reaction_10543581", "reactome": "R-CEL-2219524", "name": "PDPK1 binds PIP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10515193", "species_179856" ], "products": [ "species_10543579" ], "modifiers": [], "additional_components": [ "WBGene00021022", "Q9UA62", "WBGene00021022", "species_179856" ] }, "reaction_10513851": { "compartment": "compartment_70101", "id": "reaction_10513851", "reactome": "R-CEL-198270", "name": "PDPK1 phosphorylates AKT at T308", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10513832" ], "products": [ "species_29370", "species_10513848", "species_10508530" ], "modifiers": [ [ "species_10513832", "catalyst" ] ], "additional_components": [ "Q9UA62", "WBGene00021022", "species_179838", "Q17941", "WBGene00000102", "Q9XTG7", "WBGene00000103", "G4S4W1", "WBGene00016980", "Q9XTG7", "WBGene00000103", "G4S4W1", "WBGene00016980", "Q17941", "WBGene00000102", "Q9UA62", "WBGene00021022", "species_179838", "Q9UA62", "WBGene00021022", "species_179838", "Q17941", "WBGene00000102", "Q9XTG7", "WBGene00000103", "G4S4W1", "WBGene00016980" ] }, "reaction_10513960": { "compartment": "compartment_70101", "id": "reaction_10513960", "reactome": "R-CEL-198640", "name": "TORC2 (mTOR) phosphorylates AKT at S473", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10513939" ], "products": [ "species_29370", "species_10513830" ], "modifiers": [ [ "species_10513953", "catalyst" ], [ "species_10513958", "inhibitor" ] ], "additional_components": [ "Q17941", "WBGene00000102", "Q9XTG7", "WBGene00000103", "G4S4W1", "WBGene00016980", "species_179838", "Q17941", "WBGene00000102", "Q9XTG7", "WBGene00000103", "G4S4W1", "WBGene00016980", "species_179838", "P91040", "WBGene00015697", "Q95Q95", "WBGene00002583", "G5EFN2", "WBGene00009245", "Q9NA80", "WBGene00013261", "Q17941", "WBGene00000102", "Q9XTG7", "WBGene00000103", "G4S4W1", "WBGene00016980", "species_179838", "G5EED4", "WBGene00010700" ] }, "reaction_10509479": { "compartment": "compartment_70101", "id": "reaction_10509479", "reactome": "R-CEL-114542", "name": "RAC1,RAC2,RHOG activate PI3K", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10506892", "species_10509473" ], "products": [ "species_10509477" ], "modifiers": [], "additional_components": [ "G5EDP9", "WBGene00000001", "Q94125", "WBGene00000090", "species_29438", "Q03206", "ced-10", "Q94124", "WBGene00004287", "Q9BL44", "WBGene00022177", "species_29438", "Q03206", "ced-10", "Q94124", "WBGene00004287", "Q9BL44", "WBGene00022177", "G5EDP9", "WBGene00000001", "Q94125", "WBGene00000090" ] }, "reaction_10514322": { "compartment": "compartment_876", "id": "reaction_10514322", "reactome": "R-CEL-199443", "name": "THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10513956", "species_10513939" ], "products": [ "species_10513958" ], "modifiers": [], "additional_components": [ "WBGene00010700", "Q17941", "WBGene00000102", "Q9XTG7", "WBGene00000103", "G4S4W1", "WBGene00016980", "species_179838", "Q17941", "WBGene00000102", "Q9XTG7", "WBGene00000103", "G4S4W1", "WBGene00016980", "species_179838", "G5EED4", "WBGene00010700" ] }, "reaction_10514330": { "compartment": "compartment_70101", "id": "reaction_10514330", "reactome": "R-CEL-199456", "name": "PTEN dephosphorylates PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_179838" ], "products": [ "species_29372", "species_179856" ], "modifiers": [ [ "species_10514327", "catalyst" ] ], "additional_components": [ "WBGene00000913" ] }, "reaction_10543905": { "compartment": "compartment_70101", "id": "reaction_10543905", "reactome": "R-CEL-2317332", "name": "PIP3 recruits AKT to the membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179838", "species_10520802" ], "products": [ "species_10513939" ], "modifiers": [], "additional_components": [ "G4S4W1", "WBGene00016980", "Q17941", "WBGene00000102", "Q9XTG7", "WBGene00000103", "Q17941", "WBGene00000102", "Q9XTG7", "WBGene00000103", "G4S4W1", "WBGene00016980", "species_179838" ] }, "reaction_10565073": { "compartment": "compartment_70101", "id": "reaction_10565073", "reactome": "R-CEL-8850992", "name": "Proteasome degrades polyubiquitinated PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10565071" ], "products": [ "species_10502375" ], "modifiers": [ [ "species_10502572", "catalyst" ] ], "additional_components": [ "G5EE01", "WBGene00000913", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "P91477", "WBGene00003950", "Q95PZ7", "WBGene00013435", "Q18115", "WBGene00004459", "O62102", "WBGene00003948", "O17071", "WBGene00004504", "Q10920", "WBGene00016623", "P34286", "WBGene00003952", "Q9XTT9", "WBGene00004506", "Q23449", "WBGene00004468", "Q95005", "WBGene00003925", "P46502", "WBGene00004503", "O61792", "WBGene00004464", "O17586", "WBGene00003922", "O76371", "WBGene00004505", "Q20585", "WBGene00004463", "Q95008", "WBGene00003926", "Q18787", "WBGene00004501", "Q20058", "WBGene00009445", "Q9N599", "WBGene00003924", "O16368", "WBGene00004502", "O61742", "WBGene00004466", "Q09583", "WBGene00003928", "Q966I8", "WBGene00003947", "Q04908", "WBGene00004460", "Q9XUV0", "WBGene00003951", "Q27488", "WBGene00003923", "Q9GZH5", "WBGene00004458", "O44156", "WBGene00003927", "Q22253", "WBGene00004465", "O76577", "WBGene00004467", "P90868", "WBGene00003953", "Q19324", "WBGene00004461", "Q17971", "WBGene00007588", "Q23237", "WBGene00003949", "Q20938", "WBGene00004462" ] }, "reaction_10564578": { "compartment": "compartment_70101", "id": "reaction_10564578", "reactome": "R-CEL-8847968", "name": "PTEN binds FRK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10564574", "species_10514327" ], "products": [ "species_10564576" ], "modifiers": [], "additional_components": [ "WBGene00005078", "WBGene00000913", "G5EE01", "WBGene00000913", "O45539", "WBGene00005078" ] }, "reaction_10565061": { "compartment": "compartment_70101", "id": "reaction_10565061", "reactome": "R-CEL-8850945", "name": "Casein kinase II phosphorylates PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10514327" ], "products": [ "species_29370", "species_10565059" ], "modifiers": [ [ "species_10515097", "catalyst" ] ], "additional_components": [ "WBGene00000913", "WBGene00000913", "P18334", "WBGene00002191", "P28548", "WBGene00002196" ] }, "reaction_10563159": { "compartment": "compartment_70101", "id": "reaction_10563159", "reactome": "R-CEL-6807134", "name": "NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502375", "species_10514327" ], "products": [ "species_10563152" ], "modifiers": [ [ "species_10563156", "catalyst" ] ], "additional_components": [ "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "WBGene00000913", "WBGene00000913", "G5ECY6", "WBGene00000500", "Q9N2Z7", "WBGene00007009", "A0A061ACQ8", "WBGene00022358" ] }, "reaction_10565079": { "compartment": "compartment_70101", "id": "reaction_10565079", "reactome": "R-CEL-8850997", "name": "TRIM27 binds PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10514327", "species_10565075" ], "products": [ "species_10565077" ], "modifiers": [], "additional_components": [ "WBGene00000913", "WBGene00021640", "Q9N3T6", "WBGene00021640", "G5EE01", "WBGene00000913" ] }, "reaction_10568856": { "compartment": "compartment_70101", "id": "reaction_10568856", "reactome": "R-CEL-8948775", "name": "MKRN1 polyubiquitinates PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502375", "species_10514327" ], "products": [ "species_10563162" ], "modifiers": [ [ "species_10568851", "catalyst" ] ], "additional_components": [ "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "WBGene00000913", "WBGene00000913", "WBGene00002278" ] }, "reaction_10564584": { "compartment": "compartment_70101", "id": "reaction_10564584", "reactome": "R-CEL-8847977", "name": "FRK phosphorylates PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10564576" ], "products": [ "species_10564574", "species_29370", "species_10564581" ], "modifiers": [ [ "species_10564576", "catalyst" ] ], "additional_components": [ "G5EE01", "WBGene00000913", "O45539", "WBGene00005078", "WBGene00005078", "WBGene00000913", "G5EE01", "WBGene00000913", "O45539", "WBGene00005078" ] }, "reaction_10568861": { "compartment": "compartment_70101", "id": "reaction_10568861", "reactome": "R-CEL-8948832", "name": "RNF146 polyubiquitinates PARylated PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10568858", "species_10502375" ], "products": [ "species_10565069" ], "modifiers": [ [ "species_10547738", "catalyst" ] ], "additional_components": [ "WBGene00000913", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "WBGene00000913", "WBGene00013674" ] }, "reaction_10565085": { "compartment": "compartment_70101", "id": "reaction_10565085", "reactome": "R-CEL-8851011", "name": "TRIM27 polyubiquitinates PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502375", "species_10565077" ], "products": [ "species_10565082", "species_10565075" ], "modifiers": [ [ "species_10565077", "catalyst" ] ], "additional_components": [ "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "Q9N3T6", "WBGene00021640", "G5EE01", "WBGene00000913", "WBGene00000913", "WBGene00021640", "Q9N3T6", "WBGene00021640", "G5EE01", "WBGene00000913" ] }, "reaction_10568800": { "compartment": "compartment_13231", "id": "reaction_10568800", "reactome": "R-CEL-8944457", "name": "MAF1 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10568791" ], "products": [ "species_10568789" ], "modifiers": [ [ "species_10510588", "inhibitor" ] ], "additional_components": [ "WBGene00016622", "WBGene00016622", "Q19425", "WBGene00008774", "species_29420", "G5EGB3", "WBGene00012497", "Q22743", "WBGene00006414", "species_29438", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "P91040", "WBGene00015697", "Q95Q95", "WBGene00002583", "Q68TI8", "WBGene00000911", "P34443", "WBGene00010038" ] }, "reaction_10568738": { "compartment": "compartment_7660", "id": "reaction_10568738", "reactome": "R-CEL-8943817", "name": "MECOM (EVI1) recruits polycomb repressor complexes (PRCs) to the PTEN gene promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10568732", "species_10568730" ], "products": [ "species_10568736" ], "modifiers": [], "additional_components": [ "Q22024", "WBGene00001207", "Q22024", "WBGene00001207" ] }, "reaction_10568726": { "compartment": "compartment_7660", "id": "reaction_10568726", "reactome": "R-CEL-8943780", "name": "SALL4 recruits NuRD to PTEN gene", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10548019", "species_10568720" ], "products": [ "species_10568724" ], "modifiers": [], "additional_components": [ "P90916", "WBGene00003036", "G5EBZ4", "WBGene00002637", "Q22516", "WBGene00000482", "G5ECR1", "WBGene00023409", "O61907", "WBGene00003025", "P90917", "WBGene00004312", "G5ECH0", "WBGene00001836", "Q09440", "WBGene00001835", "G5EFF4", "WBGene00004773", "P90916", "WBGene00003036", "G5EBZ4", "WBGene00002637", "Q22516", "WBGene00000482", "G5ECR1", "WBGene00023409", "O61907", "WBGene00003025", "P90917", "WBGene00004312", "G5ECH0", "WBGene00001836", "Q09440", "WBGene00001835", "G5EFF4", "WBGene00004773" ] }, "reaction_10568798": { "compartment": "compartment_70101", "id": "reaction_10568798", "reactome": "R-CEL-8944454", "name": "mTORC1 phosphorylates MAF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10568791" ], "products": [ "species_10568796", "species_29370" ], "modifiers": [ [ "species_10510588", "catalyst" ] ], "additional_components": [ "WBGene00016622", "WBGene00016622", "Q19425", "WBGene00008774", "species_29420", "G5EGB3", "WBGene00012497", "Q22743", "WBGene00006414", "species_29438", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "P91040", "WBGene00015697", "Q95Q95", "WBGene00002583", "Q68TI8", "WBGene00000911", "P34443", "WBGene00010038" ] }, "reaction_10563141": { "compartment": "compartment_70101", "id": "reaction_10563141", "reactome": "R-CEL-6807105", "name": "Monoubiquitinated PTEN translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10563135" ], "products": [ "species_10563139" ], "modifiers": [], "additional_components": [ "WBGene00000913", "WBGene00000913" ] }, "reaction_10563146": { "compartment": "compartment_7660", "id": "reaction_10563146", "reactome": "R-CEL-6807118", "name": "USP7 deubiquitinates monoubiquitinated PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10563139" ], "products": [ "species_10502318", "species_10563143" ], "modifiers": [ [ "species_10556169", "catalyst" ], [ "species_10546215", "inhibitor" ] ], "additional_components": [ "WBGene00000913", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "WBGene00000913", "WBGene00010406", "WBGene00006523" ] }, "reaction_10563149": { "compartment": "compartment_7660", "id": "reaction_10563149", "reactome": "R-CEL-6807126", "name": "Deubiquitinated PTEN translocates to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10563143" ], "products": [ "species_10514327" ], "modifiers": [], "additional_components": [ "WBGene00000913", "WBGene00000913" ] }, "reaction_10503794": { "compartment": "compartment_70101", "id": "reaction_10503794", "reactome": "R-CEL-71164", "name": "homogentisate + O2 => maleylacetoacetate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_30337" ], "products": [ "species_31135" ], "modifiers": [ [ "species_10503791", "catalyst" ] ], "additional_components": [ "species_113531", "Q9Y041", "WBGene00001843" ] }, "reaction_10503765": { "compartment": "compartment_70101", "id": "reaction_10503765", "reactome": "R-CEL-71155", "name": "tyrosine + alpha-ketoglutarate <=> p-hydroxyphenylpyruvate + glutamate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29406", "species_29506" ], "products": [ "species_29404", "species_31365" ], "modifiers": [ [ "species_10503762", "catalyst" ] ], "additional_components": [ "Q93703", "WBGene00009628" ] }, "reaction_10503814": { "compartment": "compartment_70101", "id": "reaction_10503814", "reactome": "R-CEL-71181", "name": "fumarylacetoacetate => fumarate + acetoacetate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_31175" ], "products": [ "species_29666", "species_29586" ], "modifiers": [ [ "species_10503811", "catalyst" ] ], "additional_components": [ "Q94272", "WBGene00019620" ] }, "reaction_10503784": { "compartment": "compartment_70101", "id": "reaction_10503784", "reactome": "R-CEL-71163", "name": "p-hydroxyphenylpyruvate + O2 => homogentisate + CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_31365" ], "products": [ "species_113528", "species_30337" ], "modifiers": [ [ "species_10503781", "catalyst" ] ], "additional_components": [ "Q18347", "WBGene00016294", "Q22633", "WBGene00001993", "species_198836", "species_113531" ] }, "reaction_10503804": { "compartment": "compartment_70101", "id": "reaction_10503804", "reactome": "R-CEL-71173", "name": "maleylacetoacetate => fumarylacetoacetate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_31135" ], "products": [ "species_31175" ], "modifiers": [ [ "species_10503801", "catalyst" ] ], "additional_components": [ "Q18938", "WBGene00001790", "species_1655887" ] }, "reaction_10534912": { "compartment": "compartment_12045", "id": "reaction_10534912", "reactome": "R-CEL-1482867", "name": "DLCL is acylated to MLCL by LCLAT1 (ER)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524080", "species_1500578" ], "products": [ "species_76194", "species_1524069" ], "modifiers": [ [ "species_10507525", "catalyst" ] ], "additional_components": [ "WBGene00020264" ] }, "reaction_10534881": { "compartment": "compartment_70616", "id": "reaction_10534881", "reactome": "R-CEL-1482781", "name": "MLCL and PC are converted to CL and 1-acyl LPC by TAZ (IM) (Reversible)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524075", "species_1498773" ], "products": [ "species_1524072", "species_1524079" ], "modifiers": [ [ "species_10534878", "catalyst" ] ], "additional_components": [ "WBGene00006491" ] }, "reaction_10534899": { "compartment": "compartment_70616", "id": "reaction_10534899", "reactome": "R-CEL-1482850", "name": "MLCL and PE are converted to CL and 1-acyl LPE by TAZ (IM) (Reversible)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524083", "species_1498773" ], "products": [ "species_1524072", "species_1524089" ], "modifiers": [ [ "species_10534878", "catalyst" ] ], "additional_components": [ "WBGene00006491" ] }, "reaction_10534868": { "compartment": "compartment_70616", "id": "reaction_10534868", "reactome": "R-CEL-1482775", "name": "MLCL is acylated to CL by HADH (IM)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1498773", "species_1524038" ], "products": [ "species_1524072", "species_29374" ], "modifiers": [ [ "species_10534865", "catalyst" ] ], "additional_components": [ "P34255", "WBGene00015125", "Q9GYT0", "WBGene00020347" ] }, "reaction_10534910": { "compartment": "compartment_12045", "id": "reaction_10534910", "reactome": "R-CEL-1482861", "name": "MLCL is acylated to CL by LCLAT1 (ER)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500578", "species_1524069" ], "products": [ "species_1524081", "species_76194" ], "modifiers": [ [ "species_10507525", "catalyst" ] ], "additional_components": [ "WBGene00020264" ] }, "reaction_10520252": { "compartment": "compartment_876", "id": "reaction_10520252", "reactome": "R-CEL-381750", "name": "Olfactory Receptor - G Protein olfactory trimer complex formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10520171", "species_10520178" ], "products": [ "species_10520198" ], "modifiers": [ [ "species_10520250", "catalyst" ] ], "additional_components": [ "Q7KPV0", "WBGene00001745", "V6CLB7", "WBGene00020997", "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682", "WBGene00001052", "Q86ME6", "WBGene00001052", "Q7KPV0", "WBGene00001745", "V6CLB7", "WBGene00020997", "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682", "Q10010", "WBGene00020562", "P34296", "WBGene00020562" ] }, "reaction_10520173": { "compartment": "compartment_876", "id": "reaction_10520173", "reactome": "R-CEL-381749", "name": "G Protein trimer formation (olfactory)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509147", "species_10510821", "species_10511281" ], "products": [ "species_10520171" ], "modifiers": [], "additional_components": [ "WBGene00001682", "WBGene00001679", "Q7KPV0", "WBGene00001745", "V6CLB7", "WBGene00020997", "Q7KPV0", "WBGene00001745", "V6CLB7", "WBGene00020997", "P17343", "WBGene00001679", "G5ECT6", "WBGene00001682" ] }, "reaction_10568896": { "compartment": "compartment_70616", "id": "reaction_10568896", "reactome": "R-CEL-8949580", "name": "F1Fo ATP synthase dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10510406" ], "products": [ "species_10568894" ], "modifiers": [], "additional_components": [ "O16314", "WBGene00015460", "Q18803", "WBGene00000210", "Q17763", "WBGene00007385", "Q19126", "WBGene00000207", "Q9BKS0", "WBGene00022336", "Q21732", "WBGene00011015", "O16517", "WBGene00020275", "Q22021", "WBGene00011273", "Q09544", "WBGene00019061", "Q9XXK1", "WBGene00010419", "O16298", "WBGene00017982", "P46561", "WBGene00000229", "Q95XJ0", "WBGene00022089", "Q7JNG1", "WBGene00000230", "O16314", "WBGene00015460", "Q18803", "WBGene00000210", "Q17763", "WBGene00007385", "Q19126", "WBGene00000207", "Q9BKS0", "WBGene00022336", "Q21732", "WBGene00011015", "O16517", "WBGene00020275", "Q22021", "WBGene00011273", "Q09544", "WBGene00019061", "Q9XXK1", "WBGene00010419", "O16298", "WBGene00017982", "P46561", "WBGene00000229", "Q95XJ0", "WBGene00022089", "Q7JNG1", "WBGene00000230" ] }, "reaction_10549204": { "compartment": "compartment_12045", "id": "reaction_10549204", "reactome": "R-CEL-4419979", "name": "SRD5A3 reduces pPNOL to DCHOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_4419981", "species_29364" ], "products": [ "species_29366", "species_449221" ], "modifiers": [ [ "species_10549201", "catalyst" ] ], "additional_components": [ "WBGene00007102" ] }, "reaction_10525099": { "compartment": "compartment_12045", "id": "reaction_10525099", "reactome": "R-CEL-446195", "name": "DOLK phosphorylates DCHOL to DOLP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_110614", "species_449221" ], "products": [ "species_110094", "species_449299" ], "modifiers": [ [ "species_10525096", "catalyst" ] ], "additional_components": [ "WBGene00044233" ] }, "reaction_10549196": { "compartment": "compartment_12045", "id": "reaction_10549196", "reactome": "R-CEL-4419978", "name": "DHDDS:NUS1 elongates E,E-FPP with (n)IPPP to form pPPP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191362", "species_4419987" ], "products": [ "species_4419982" ], "modifiers": [ [ "species_10549193", "catalyst" ] ], "additional_components": [ "Q5FC21", "WBGene00044025", "Q20118", "WBGene00009505" ] }, "reaction_10523190": { "compartment": "compartment_17938", "id": "reaction_10523190", "reactome": "R-CEL-428585", "name": "SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428040", "species_428639" ], "products": [ "species_428633", "species_70106" ], "modifiers": [ [ "species_10523187", "catalyst" ] ], "additional_components": [ "WBGene00008000" ] }, "reaction_10525409": { "compartment": "compartment_70101", "id": "reaction_10525409", "reactome": "R-CEL-449715", "name": "GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29512", "species_29472" ], "products": [ "species_29404", "species_449701" ], "modifiers": [ [ "species_10525406", "catalyst" ] ], "additional_components": [ "Q19130", "WBGene00008546", "Q19699", "WBGene00009035" ] }, "reaction_10525137": { "compartment": "compartment_70101", "id": "reaction_10525137", "reactome": "R-CEL-446204", "name": "GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29494", "species_532204" ], "products": [ "species_111294", "species_162756" ], "modifiers": [ [ "species_10525134", "catalyst" ] ], "additional_components": [ "Q18493", "WBGene00007965" ] }, "reaction_10563013": { "compartment": "compartment_70101", "id": "reaction_10563013", "reactome": "R-CEL-6803771", "name": "NAGK dimer phosphorylates GlcNAc, GlcNGc to GlcNAc-6-P, GlcNGc-6-P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6803785", "species_113592" ], "products": [ "species_6803738", "species_70106", "species_29370" ], "modifiers": [ [ "species_10563010", "catalyst" ] ], "additional_components": [ "CHEBI:27459", "species_1678743", "species_449703", "species_6803743", "Q23196", "WBGene00021056" ] }, "reaction_10525061": { "compartment": "compartment_70101", "id": "reaction_10525061", "reactome": "R-CEL-446185", "name": "Isomerization of GlcNAc6P to GlcNAc1P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449703" ], "products": [ "species_532204" ], "modifiers": [ [ "species_10525058", "catalyst" ] ], "additional_components": [ "WBGene00009006" ] }, "reaction_10525419": { "compartment": "compartment_70101", "id": "reaction_10525419", "reactome": "R-CEL-449734", "name": "Acetylation of glucosamine 6-phosphate to GlcNAc6P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76183", "species_449701" ], "products": [ "species_76194", "species_449703" ], "modifiers": [ [ "species_10525416", "catalyst" ] ], "additional_components": [ "Q17427", "WBGene00001646" ] }, "reaction_10563021": { "compartment": "compartment_70101", "id": "reaction_10563021", "reactome": "R-CEL-6803789", "name": "AMDHD2 hydrolyses GlcNGc-6-P to GlcN6P and CCA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_6803743" ], "products": [ "species_193473", "species_449701" ], "modifiers": [ [ "species_10563018", "catalyst" ] ], "additional_components": [ "WBGene00010308" ] }, "reaction_10527233": { "compartment": "compartment_70101", "id": "reaction_10527233", "reactome": "R-CEL-532549", "name": "MPI isomerises Fru6P to Man6P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29512" ], "products": [ "species_532562" ], "modifiers": [ [ "species_10527230", "catalyst" ] ], "additional_components": [ "WBGene00014013" ] }, "reaction_10525119": { "compartment": "compartment_70101", "id": "reaction_10525119", "reactome": "R-CEL-446201", "name": "PMM1,2 isomerise Man6P to Man1P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_532562" ], "products": [ "species_532531" ], "modifiers": [ [ "species_10525116", "catalyst" ] ], "additional_components": [ "Q9XUE6", "WBGene00009925" ] }, "reaction_10558241": { "compartment": "compartment_70101", "id": "reaction_10558241", "reactome": "R-CEL-6787540", "name": "FUK phosphorylates beta-Fuc to Fuc1P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_6787678" ], "products": [ "species_29370", "species_6787542" ], "modifiers": [ [ "species_10558238", "catalyst" ] ], "additional_components": [ "WBGene00007745" ] }, "reaction_10558259": { "compartment": "compartment_70101", "id": "reaction_10558259", "reactome": "R-CEL-6787632", "name": "GMDS dehydrates GDP-Man to GDP-DHDMan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_162860" ], "products": [ "species_29356", "species_6787618" ], "modifiers": [ [ "species_10558256", "catalyst" ] ], "additional_components": [ "WBGene00000266" ] }, "reaction_10558262": { "compartment": "compartment_70101", "id": "reaction_10558262", "reactome": "R-CEL-6787642", "name": "TSTA3 dimer reduces GDP-KDGal to GDP-Fuc", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_6787646", "species_29364" ], "products": [ "species_742368", "species_29366" ], "modifiers": [ [ "species_10558248", "catalyst" ] ], "additional_components": [ "G5EER4", "WBGene00019813" ] }, "reaction_10558233": { "compartment": "compartment_70101", "id": "reaction_10558233", "reactome": "R-CEL-6787533", "name": "FPGT transfers guanylyl group from GTP to Fuc1P to form GDP-Fuc", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_6787542" ], "products": [ "species_111294", "species_742368" ], "modifiers": [ [ "species_10558230", "catalyst" ] ], "additional_components": [ "WBGene00044903" ] }, "reaction_10558251": { "compartment": "compartment_70101", "id": "reaction_10558251", "reactome": "R-CEL-6787623", "name": "TSTA3 dimer epimerises GDP-DHDMan to GDP-KDGal", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6787618" ], "products": [ "species_6787646" ], "modifiers": [ [ "species_10558248", "catalyst" ] ], "additional_components": [ "G5EER4", "WBGene00019813" ] }, "reaction_10555857": { "compartment": "compartment_7660", "id": "reaction_10555857", "reactome": "R-CEL-5685230", "name": "CHEK1 phosphorylates RAD51", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10555852" ], "products": [ "species_113582", "species_10555855" ], "modifiers": [ [ "species_10502788", "catalyst" ] ], "additional_components": [ "WBGene00004297", "WBGene00004297", "WBGene00000498" ] }, "reaction_10503589": { "compartment": "compartment_5460", "id": "reaction_10503589", "reactome": "R-CEL-70979", "name": "(S)-Malate + NAD+ <=> Oxaloacetate + NADH + H+", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113544", "species_113526" ], "products": [ "species_113529", "species_29362", "species_113587" ], "modifiers": [ [ "species_10503586", "catalyst" ] ], "additional_components": [ "O02640", "WBGene00003162" ] }, "reaction_10504295": { "compartment": "compartment_5460", "id": "reaction_10504295", "reactome": "R-CEL-71775", "name": "GDP + Orthophosphate + Succinyl-CoA <=> GTP + Succinate + CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70958", "species_113548", "species_113525" ], "products": [ "species_29374", "species_113573", "species_113536" ], "modifiers": [ [ "species_10504292", "catalyst" ] ], "additional_components": [ "P53596", "WBGene00007350", "P53589", "WBGene00016844" ] }, "reaction_10503561": { "compartment": "compartment_5460", "id": "reaction_10503561", "reactome": "R-CEL-70967", "name": "isocitrate + NAD+ => alpha-ketoglutarate + CO2 + NADH + H+ [IDH3]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113526", "species_29938" ], "products": [ "species_113594", "species_113529", "species_29362", "species_29376" ], "modifiers": [ [ "species_10503558", "catalyst" ], [ "species_113581", "catalyst" ] ], "additional_components": [ "Q20049", "WBGene00009440", "species_266099", "Q93714", "WBGene00009664", "Q93353", "WBGene00007993" ] }, "reaction_10525994": { "compartment": "compartment_5462", "id": "reaction_10525994", "reactome": "R-CEL-450971", "name": "NADPH + NAD+ + H+ [cytosol] => NADP+ + NADH + H+ [mitochondrial matrix]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_113526", "species_113600" ], "products": [ "species_113563", "species_113529", "species_29362" ], "modifiers": [ [ "species_10525991", "catalyst" ] ], "additional_components": [ "Q18031", "WBGene00003778" ] }, "reaction_10570923": { "compartment": "compartment_5460", "id": "reaction_10570923", "reactome": "R-CEL-9012349", "name": "ME3:Mg2+ tetramer oxidatively decarboxylates MAL to PYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113563", "species_113544" ], "products": [ "species_113529", "species_113557", "species_113600", "species_29376" ], "modifiers": [ [ "species_10570920", "catalyst" ] ], "additional_components": [ "Q9U296", "WBGene00012983", "species_114632" ] }, "reaction_10525996": { "compartment": "compartment_5460", "id": "reaction_10525996", "reactome": "R-CEL-450975", "name": "isocitrate <=> citrate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29938" ], "products": [ "species_29654" ], "modifiers": [ [ "species_10503566", "catalyst" ] ], "additional_components": [ "WBGene00000041" ] }, "reaction_10503628": { "compartment": "compartment_5460", "id": "reaction_10503628", "reactome": "R-CEL-70994", "name": "Succinate <=> Fumarate (with FAD redox reaction on enzyme)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113536" ], "products": [ "species_113588" ], "modifiers": [ [ "species_10503625", "catalyst" ] ], "additional_components": [ "P41956", "WBGene00003225", "Q09508", "WBGene00015391", "species_113596", "O62215", "WBGene00009353", "Q09545", "WBGene00006433" ] }, "reaction_10503599": { "compartment": "compartment_5460", "id": "reaction_10503599", "reactome": "R-CEL-70982", "name": "Fumarate + H2O <=> (S)-Malate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113588", "species_113521" ], "products": [ "species_113544" ], "modifiers": [ [ "species_10503596", "catalyst" ] ], "additional_components": [ "O17214", "WBGene00001503" ] }, "reaction_10570899": { "compartment": "compartment_5460", "id": "reaction_10570899", "reactome": "R-CEL-9012268", "name": "ME2:Mg2+ tetramer oxidatively decarboxylates MAL to PYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113544", "species_113526" ], "products": [ "species_113529", "species_113557", "species_29362", "species_29376" ], "modifiers": [ [ "species_10570896", "catalyst" ], [ "species_113588", "catalyst" ], [ "species_113593", "inhibitor" ] ], "additional_components": [ "species_114632", "Q9U296", "WBGene00012983" ] }, "reaction_10503988": { "compartment": "compartment_5460", "id": "reaction_10503988", "reactome": "R-CEL-71401", "name": "alpha-ketoglutarate + CoASH + NAD+ => succinyl-CoA + CO2 + NADH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_113594", "species_113526" ], "products": [ "species_70958", "species_29362", "species_29376" ], "modifiers": [ [ "species_10503711", "catalyst" ] ], "additional_components": [ "O61199", "WBGene00020679", "species_8878387", "CHEBI:17460", "O45148", "WBGene00020950", "O17953", "WBGene00010794", "species_113596" ] }, "reaction_10526006": { "compartment": "compartment_5460", "id": "reaction_10526006", "reactome": "R-CEL-450984", "name": "isocitrate + NADP+ => alpha-ketoglutarate + CO2 + NADPH + H+ [IDH2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113563", "species_29938" ], "products": [ "species_113594", "species_113529", "species_113600", "species_29376" ], "modifiers": [ [ "species_10526003", "catalyst" ] ], "additional_components": [ "O17643", "WBGene00007942", "species_266099" ] }, "reaction_10503579": { "compartment": "compartment_5460", "id": "reaction_10503579", "reactome": "R-CEL-70975", "name": "Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113559", "species_113587", "species_113521" ], "products": [ "species_29374", "species_29654" ], "modifiers": [ [ "species_10503576", "catalyst" ] ], "additional_components": [ "P34575", "WBGene00000833" ] }, "reaction_10503643": { "compartment": "compartment_5460", "id": "reaction_10503643", "reactome": "R-CEL-70997", "name": "ADP + Orthophosphate + Succinyl-CoA <=> ATP + Succinate + CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70958", "species_113548", "species_113581" ], "products": [ "species_29374", "species_113593", "species_113536" ], "modifiers": [ [ "species_10503640", "catalyst" ] ], "additional_components": [ "P53596", "WBGene00007350", "P53588", "WBGene00009812" ] }, "reaction_10570874": { "compartment": "compartment_5460", "id": "reaction_10570874", "reactome": "R-CEL-9012016", "name": "FAHD1:Zn2+ dimer hydrolyses OA to PYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113587" ], "products": [ "species_113557", "species_29376" ], "modifiers": [ [ "species_10570871", "catalyst" ] ], "additional_components": [ "P34673", "WBGene00022798", "species_114632" ] }, "reaction_10528274": { "compartment": "compartment_5460", "id": "reaction_10528274", "reactome": "R-CEL-880002", "name": "(R)-2-hydroxyglutarate + succinate semialdehyde <=> 2-oxoglutarate + 4-hydroxybutyrate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_880046", "species_879997" ], "products": [ "species_113594", "species_880041" ], "modifiers": [ [ "species_10528271", "catalyst" ] ], "additional_components": [ "WBGene00012608" ] }, "reaction_10528292": { "compartment": "compartment_70616", "id": "reaction_10528292", "reactome": "R-CEL-880050", "name": "(S)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113596", "species_880013" ], "products": [ "species_113594", "species_31649" ], "modifiers": [ [ "species_10528289", "catalyst" ] ], "additional_components": [ "WBGene00021564" ] }, "reaction_10528282": { "compartment": "compartment_5460", "id": "reaction_10528282", "reactome": "R-CEL-880007", "name": "(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113596", "species_879997" ], "products": [ "species_113594", "species_31649" ], "modifiers": [ [ "species_10528279", "catalyst" ], [ "species_880069", "catalyst" ], [ "species_880067", "catalyst" ], [ "species_113527", "catalyst" ] ], "additional_components": [ "WBGene00010055" ] }, "reaction_10563171": { "compartment": "compartment_5460", "id": "reaction_10563171", "reactome": "R-CEL-6807826", "name": "LDHAL6B reduces PYR to LACT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113529", "species_113557", "species_29362" ], "products": [ "species_113526", "species_6807616" ], "modifiers": [ [ "species_10563168", "catalyst" ] ], "additional_components": [ "WBGene00002262" ] }, "reaction_10503986": { "compartment": "compartment_5460", "id": "reaction_10503986", "reactome": "R-CEL-71397", "name": "lipo-PDH decarboxylates PYR to Ac-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_113526", "species_113557" ], "products": [ "species_113559", "species_29362", "species_29376" ], "modifiers": [ [ "species_10503983", "catalyst" ] ], "additional_components": [ "P52899", "WBGene00011510", "O44451", "WBGene00015413", "species_8878387", "Q19749", "WBGene00009082", "O17953", "WBGene00010794", "species_113596" ] }, "reaction_10557975": { "compartment": "compartment_70101", "id": "reaction_10557975", "reactome": "R-CEL-6783221", "name": "HAGH hydrolyses (R)-S-LGSH to GSH and LACT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5694130" ], "products": [ "species_29708", "species_29450" ], "modifiers": [ [ "species_10557972", "catalyst" ] ], "additional_components": [ "species_216785", "Q9XXJ1", "WBGene00012459" ] }, "reaction_10503144": { "compartment": "compartment_70101", "id": "reaction_10503144", "reactome": "R-CEL-70510", "name": "LDH tetramer oxidises LACT to PYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29708", "species_29360" ], "products": [ "species_70106", "species_29398", "species_73473" ], "modifiers": [ [ "species_10503141", "catalyst" ] ], "additional_components": [ "Q27888", "WBGene00002262" ] }, "reaction_10570888": { "compartment": "compartment_70101", "id": "reaction_10570888", "reactome": "R-CEL-9012036", "name": "ME1:Mg2+ tetramer oxidatively decarboxylates MAL to PYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29366", "species_198498" ], "products": [ "species_70106", "species_113528", "species_29398", "species_29364" ], "modifiers": [ [ "species_10570885", "catalyst" ] ], "additional_components": [ "species_114632", "Q9U296", "WBGene00012983" ] }, "reaction_10570839": { "compartment": "compartment_5460", "id": "reaction_10570839", "reactome": "R-CEL-9011543", "name": "DCA binds PDK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9010792", "species_10515600" ], "products": [ "species_10515607" ], "modifiers": [], "additional_components": [ "WBGene00022719", "Q02332", "WBGene00022719" ] }, "reaction_10515609": { "compartment": "compartment_5460", "id": "reaction_10515609", "reactome": "R-CEL-203946", "name": "PDK isoforms phosphorylate lipo-PDH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10503983", "species_113593" ], "products": [ "species_113581", "species_10515593" ], "modifiers": [ [ "species_10515598", "catalyst" ], [ "species_29362", "catalyst" ], [ "species_113559", "catalyst" ], [ "species_10514503", "catalyst" ], [ "species_113557", "inhibitor" ], [ "species_10515607", "inhibitor" ] ], "additional_components": [ "P52899", "WBGene00011510", "O44451", "WBGene00015413", "species_8878387", "Q19749", "WBGene00009082", "O17953", "WBGene00010794", "species_113596", "P52899", "WBGene00011510", "O44451", "WBGene00015413", "species_8878387", "Q19749", "WBGene00009082", "O17953", "WBGene00010794", "species_113596", "WBGene00022719", "Q9XUK7", "WBGene00003675", "P41830", "WBGene00004786", "Q10902", "WBGene00003601", "Q20765", "WBGene00003606", "Q9U2R6", "WBGene00003681", "species_5334816", "Q02332", "WBGene00022719" ] }, "reaction_10570846": { "compartment": "compartment_5460", "id": "reaction_10570846", "reactome": "R-CEL-9011595", "name": "GSTZ1 dimer dehalogenates DCA to glyoxylate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9010792", "species_113521" ], "products": [ "species_904849", "species_3301973" ], "modifiers": [ [ "species_10570843", "catalyst" ], [ "species_1655887", "catalyst" ], [ "species_9010792", "inhibitor" ] ], "additional_components": [ "species_1655887", "Q18938", "WBGene00001790" ] }, "reaction_10515983": { "compartment": "compartment_5460", "id": "reaction_10515983", "reactome": "R-CEL-204169", "name": "PDP dephosphorylates p-lipo-PDH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10515593", "species_113521" ], "products": [ "species_10503983", "species_113548" ], "modifiers": [ [ "species_10515980", "catalyst" ], [ "species_109496", "catalyst" ] ], "additional_components": [ "P52899", "WBGene00011510", "O44451", "WBGene00015413", "species_8878387", "Q19749", "WBGene00009082", "O17953", "WBGene00010794", "species_113596", "P52899", "WBGene00011510", "O44451", "WBGene00015413", "species_8878387", "Q19749", "WBGene00009082", "O17953", "WBGene00010794", "species_113596", "Q9U300", "WBGene00013718", "species_113596", "Q9N4M0", "WBGene00022832" ] }, "reaction_10504332": { "compartment": "compartment_70101", "id": "reaction_10504332", "reactome": "R-CEL-71849", "name": "LDH tetramer reduces PYR to LACT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29398", "species_73473" ], "products": [ "species_29708", "species_29360" ], "modifiers": [ [ "species_10503141", "catalyst" ] ], "additional_components": [ "Q27888", "WBGene00002262" ] }, "reaction_10570926": { "compartment": "compartment_70101", "id": "reaction_10570926", "reactome": "R-CEL-9012374", "name": "VDAC1 transports PYR from cytosol to mitochondrial intermembrane space", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29398" ], "products": [ "species_9012375" ], "modifiers": [ [ "species_10550419", "catalyst" ] ], "additional_components": [ "WBGene00019900" ] }, "reaction_10532289": { "compartment": "compartment_70101", "id": "reaction_10532289", "reactome": "R-CEL-1237096", "name": "Methylthio-ribose-P = Methylthio-ribulose-P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1237165" ], "products": [ "species_1237107" ], "modifiers": [ [ "species_10532286", "catalyst" ] ], "additional_components": [ "WBGene00007236" ] }, "reaction_10532309": { "compartment": "compartment_70101", "id": "reaction_10532309", "reactome": "R-CEL-1237129", "name": "Acireductone is created", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1237176" ], "products": [ "species_29372", "species_70106", "species_1237155" ], "modifiers": [ [ "species_10532306", "catalyst" ] ], "additional_components": [ "Q21012", "WBGene00010286", "species_114632" ] }, "reaction_10532299": { "compartment": "compartment_70101", "id": "reaction_10532299", "reactome": "R-CEL-1237119", "name": "Acireductone is oxidized to MOB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_1237155" ], "products": [ "species_29460", "species_1237122" ], "modifiers": [ [ "species_10532296", "catalyst" ] ], "additional_components": [ "Q20340", "WBGene00009636", "species_113531" ] }, "reaction_10532319": { "compartment": "compartment_70101", "id": "reaction_10532319", "reactome": "R-CEL-1237160", "name": "MTA is cleaved and phosphorylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29372", "species_353106" ], "products": [ "species_1237165", "species_83951" ], "modifiers": [ [ "species_10532316", "catalyst" ] ], "additional_components": [ "Q09438", "WBGene00015064" ] }, "reaction_10510738": { "compartment": "compartment_70616", "id": "reaction_10510738", "reactome": "R-CEL-166214", "name": "FA anion flip-flops to the opposite surface", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10510733" ], "products": [ "species_10510735" ], "modifiers": [ [ "species_10510733", "catalyst" ] ], "additional_components": [ "species_166216", "O01883", "WBGene00006729", "species_166216", "O01883", "WBGene00006729", "species_166216", "O01883", "WBGene00006729" ] }, "reaction_10510740": { "compartment": "compartment_70616", "id": "reaction_10510740", "reactome": "R-CEL-166220", "name": "FA anion diffuses laterally to UCP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10510731", "species_166213" ], "products": [ "species_10510733" ], "modifiers": [], "additional_components": [ "O01883", "WBGene00006729", "species_166216", "O01883", "WBGene00006729" ] }, "reaction_10510742": { "compartment": "compartment_70616", "id": "reaction_10510742", "reactome": "R-CEL-166387", "name": "The FA anion diffuses away laterally from UCP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10510735" ], "products": [ "species_10510731", "species_166216" ], "modifiers": [], "additional_components": [ "species_166216", "O01883", "WBGene00006729", "O01883", "WBGene00006729" ] }, "reaction_10511077": { "compartment": "compartment_70616", "id": "reaction_10511077", "reactome": "R-CEL-170026", "name": "Protons are translocated from the intermembrane space to the matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_163953" ], "products": [ "species_113529" ], "modifiers": [ [ "species_10510731", "catalyst" ], [ "species_30495", "catalyst" ], [ "species_170037", "inhibitor" ] ], "additional_components": [ "O01883", "WBGene00006729", "species_29358", "species_113582", "species_29420", "species_29438" ] }, "reaction_10567812": { "compartment": "compartment_7660", "id": "reaction_10567812", "reactome": "R-CEL-8878143", "name": "RUNX3 binds SMAD3 and SMAD4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10566205", "species_10567808" ], "products": [ "species_10567810" ], "modifiers": [], "additional_components": [ "WBGene00004393", "P45897", "WBGene00004858", "Q21733", "WBGene00000904", "P45897", "WBGene00004858", "Q21733", "WBGene00000904", "G5EFQ5", "WBGene00004393" ] }, "reaction_10567805": { "compartment": "compartment_7660", "id": "reaction_10567805", "reactome": "R-CEL-8878117", "name": "RUNX3 binds ZFHX3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10566205", "species_10567801" ], "products": [ "species_10567803" ], "modifiers": [ [ "species_10511431", "catalyst" ] ], "additional_components": [ "WBGene00004393", "WBGene00022518", "V6CLN5", "WBGene00022518", "G5EFQ5", "WBGene00004393", "G5EBY8", "WBGene00006852", "G5EEL5", "WBGene00000936" ] }, "reaction_10520769": { "compartment": "compartment_17951", "id": "reaction_10520769", "reactome": "R-CEL-390256", "name": "hexacosanoyl-CoA + O2 => trans-2,3-dehydrohexacosanoyl-CoA + H2O2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113535", "species_390260" ], "products": [ "species_390249", "species_113575" ], "modifiers": [ [ "species_10520766", "catalyst" ] ], "additional_components": [ "species_113596", "O62138", "WBGene00008566" ] }, "reaction_10520758": { "compartment": "compartment_17951", "id": "reaction_10520758", "reactome": "R-CEL-390251", "name": "HSD17B4 dehydrogenates 3-hydroxyhexacosanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_390248", "species_192307" ], "products": [ "species_193465", "species_390241", "species_192305" ], "modifiers": [ [ "species_10513270", "catalyst" ] ], "additional_components": [ "Q19058", "WBGene00017123" ] }, "reaction_10520808": { "compartment": "compartment_17947", "id": "reaction_10520808", "reactome": "R-CEL-390393", "name": "Peroxisomal uptake of very long-chain fatty acyl CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_390394" ], "products": [ "species_390260" ], "modifiers": [ [ "species_10520381", "catalyst" ] ], "additional_components": [ "O45730", "WBGene00004061" ] }, "reaction_10520760": { "compartment": "compartment_17951", "id": "reaction_10520760", "reactome": "R-CEL-390252", "name": "HSD17B4 hydrates trans-2,3-dehydrohexacosanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_141343", "species_390249" ], "products": [ "species_390248" ], "modifiers": [ [ "species_10513270", "catalyst" ] ], "additional_components": [ "Q19058", "WBGene00017123" ] }, "reaction_10563641": { "compartment": "compartment_17951", "id": "reaction_10563641", "reactome": "R-CEL-6809263", "name": "EHHADH hydrates trans-2,3-dehydrohexacosanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_141343", "species_390249" ], "products": [ "species_390248" ], "modifiers": [ [ "species_10563638", "catalyst" ] ], "additional_components": [ "WBGene00001157" ] }, "reaction_10556490": { "compartment": "compartment_17951", "id": "reaction_10556490", "reactome": "R-CEL-5690042", "name": "Peroxisomal ACOT4,6,8 hydrolyse MCFA-CoA, LCFA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5690520", "species_141343" ], "products": [ "species_5690539", "species_193514" ], "modifiers": [ [ "species_10556487", "catalyst" ] ], "additional_components": [ "species_164991", "species_5690542", "species_5690531", "species_174602", "O45003", "WBGene00020989", "Q9GYN3", "WBGene00020989", "B3WFZ3", "WBGene00020989", "O01862", "WBGene00020989", "Q9BIA9", "WBGene00015887" ] }, "reaction_10530620": { "compartment": "compartment_17951", "id": "reaction_10530620", "reactome": "R-CEL-977317", "name": "malonyl-CoA is decarboxylated to acetyl-CoA in peroxisome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_977323" ], "products": [ "species_353123", "species_389536" ], "modifiers": [ [ "species_10530617", "catalyst" ] ], "additional_components": [ "WBGene00009439" ] }, "reaction_10563644": { "compartment": "compartment_17951", "id": "reaction_10563644", "reactome": "R-CEL-6809264", "name": "EHHADH dehydrogenates 3-hydroxyhexacosanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_390248", "species_192307" ], "products": [ "species_193465", "species_390241", "species_192305" ], "modifiers": [ [ "species_10563638", "catalyst" ] ], "additional_components": [ "WBGene00001157" ] }, "reaction_10520641": { "compartment": "compartment_17951", "id": "reaction_10520641", "reactome": "R-CEL-389632", "name": "pristanate + CoA-SH + ATP => pristanoyl-CoA + AMP + pyrophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6811612", "species_193514", "species_389573" ], "products": [ "species_389593", "species_389569", "species_389620" ], "modifiers": [ [ "species_10520635", "catalyst" ] ], "additional_components": [ "Q18916", "WBGene00017012", "Q19878", "WBGene00009218" ] }, "reaction_10520629": { "compartment": "compartment_17951", "id": "reaction_10520629", "reactome": "R-CEL-389611", "name": "2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_389594" ], "products": [ "species_389578", "species_389636" ], "modifiers": [ [ "species_10520626", "catalyst" ] ], "additional_components": [ "species_8878387", "species_114632", "Q17474", "WBGene00007143" ] }, "reaction_10520617": { "compartment": "compartment_17951", "id": "reaction_10520617", "reactome": "R-CEL-389609", "name": "ALDH3A2-2 oxidizes pristanal to pristanate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_389636", "species_192307" ], "products": [ "species_193465", "species_6811612", "species_192305" ], "modifiers": [ [ "species_10520614", "catalyst" ] ], "additional_components": [ "O44555", "WBGene00000111", "A0A486WWU7", "WBGene00000110" ] }, "reaction_10520651": { "compartment": "compartment_17951", "id": "reaction_10520651", "reactome": "R-CEL-389639", "name": "phytanoyl-CoA + 2-oxoglutarate + O2 => 2-hydroxyphytanoyl-CoA + succinate + CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113535", "species_389615", "species_389537" ], "products": [ "species_389594", "species_389583", "species_389536" ], "modifiers": [ [ "species_10520648", "catalyst" ] ], "additional_components": [ "O62515", "WBGene00014000", "species_113531" ] }, "reaction_10520638": { "compartment": "compartment_17951", "id": "reaction_10520638", "reactome": "R-CEL-389622", "name": "phytanate + CoA-SH + ATP => phytanoyl-CoA + AMP + pyrophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_389596", "species_193514", "species_389573" ], "products": [ "species_389593", "species_389615", "species_389620" ], "modifiers": [ [ "species_10520635", "catalyst" ] ], "additional_components": [ "Q18916", "WBGene00017012", "Q19878", "WBGene00009218" ] }, "reaction_10564665": { "compartment": "compartment_17947", "id": "reaction_10564665", "reactome": "R-CEL-8848247", "name": "ACBD4,5 bind MCFA-CoA and LCFA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5690520", "species_10564661" ], "products": [ "species_10564663" ], "modifiers": [], "additional_components": [ "species_164991", "species_5690542", "A0A1D3PCN1", "WBGene00270319", "Q9XTZ5", "WBGene00007680", "A0A1D3PCN1", "WBGene00270319", "Q9XTZ5", "WBGene00007680", "species_164991", "species_5690542" ] }, "reaction_10558271": { "compartment": "compartment_17951", "id": "reaction_10558271", "reactome": "R-CEL-6787811", "name": "HAO2 tetramer oxidises 2OH-PALM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113535", "species_6787810" ], "products": [ "species_113575", "species_6787814" ], "modifiers": [ [ "species_10558268", "catalyst" ] ], "additional_components": [ "B1GRK5", "WBGene00018286" ] }, "reaction_10563806": { "compartment": "compartment_17951", "id": "reaction_10563806", "reactome": "R-CEL-6810474", "name": "NUDT19 hydrolyses acyl-CoA to 3',5'-ADP and acyl-PPANT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_141343", "species_6810523" ], "products": [ "species_6809360", "species_6810530" ], "modifiers": [ [ "species_10563803", "catalyst" ] ], "additional_components": [ "WBGene00003584" ] }, "reaction_10516209": { "compartment": "compartment_70101", "id": "reaction_10516209", "reactome": "R-CEL-205136", "name": "GTP-bound RAC contributes to JNK activation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10510931" ], "products": [ "species_29370", "species_10510951" ], "modifiers": [ [ "species_10516065", "catalyst" ] ], "additional_components": [ "WBGene00002178", "WBGene00002178", "Q03206", "ced-10", "species_29438" ] }, "reaction_10516179": { "compartment": "compartment_70101", "id": "reaction_10516179", "reactome": "R-CEL-205039", "name": "p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10516063", "species_29438" ], "products": [ "species_29420", "species_10516065" ], "modifiers": [ [ "species_10516176", "catalyst" ] ], "additional_components": [ "species_29420", "Q03206", "ced-10", "Q03206", "ced-10", "species_29438", "G5EFE1", "WBGene00006468", "H2L0P5", "WBGene00022391", "G5EF62", "WBGene00009337", "Q9U3P2", "WBGene00007750", "X5LV34", "WBGene00001366", "S6EZU2", "WBGene00006476", "Q45FX5", "WBGene00006887", "Q21653", "WBGene00019832", "A0A0K3AQN0", "WBGene00013682", "O01847", "WBGene00015704", "Q965J0", "WBGene00019487", "Q21430", "WBGene00010776", "H2KYI7", "WBGene00006496", "Q9N5D3", "WBGene00004947", "Q9U364", "WBGene00002297", "A0A0K3AS36", "Y116A8C.36d", "Q19572", "WBGene00001674", "species_29438" ] }, "reaction_10513418": { "compartment": "compartment_13231", "id": "reaction_10513418", "reactome": "R-CEL-193666", "name": "Active JNK moves to the nucleus and phosphorylates different transcription factors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10510951" ], "products": [ "species_10510872" ], "modifiers": [], "additional_components": [ "WBGene00002178", "WBGene00002178" ] }, "reaction_10523262": { "compartment": "compartment_70101", "id": "reaction_10523262", "reactome": "R-CEL-428750", "name": "Gq activation by TP receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10523257" ], "products": [ "species_29420", "species_10523259" ], "modifiers": [ [ "species_10523257", "catalyst" ] ], "additional_components": [ "CHEBI:15627", "species_29420", "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "CHEBI:15627", "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196", "species_29438", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "CHEBI:15627", "species_29420", "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196", "P17343", "WBGene00001679", "P54406", "WBGene00001681" ] }, "reaction_10523342": { "compartment": "compartment_70101", "id": "reaction_10523342", "reactome": "R-CEL-428917", "name": "G13 activation by TP receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10523337" ], "products": [ "species_29420", "species_10523339" ], "modifiers": [ [ "species_10523337", "catalyst" ] ], "additional_components": [ "species_29420", "Q19572", "WBGene00001674", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "CHEBI:15627", "CHEBI:15627", "Q19572", "WBGene00001674", "species_29438", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "species_29420", "Q19572", "WBGene00001674", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "CHEBI:15627" ] }, "reaction_10546012": { "compartment": "compartment_7660", "id": "reaction_10546012", "reactome": "R-CEL-2990833", "name": "Conjugation of SUMO1 to UBA2:SAE1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10545999", "species_29358", "species_10528096" ], "products": [ "species_164121", "species_10546009", "species_113541" ], "modifiers": [ [ "species_10545999", "catalyst" ] ], "additional_components": [ "Q17820", "WBGene00000142", "Q9NAN1", "WBGene00006700", "WBGene00004888", "Q9NAN1", "WBGene00006700", "P55853", "WBGene00004888", "Q17820", "WBGene00000142", "Q17820", "WBGene00000142", "Q9NAN1", "WBGene00006700" ] }, "reaction_10546368": { "compartment": "compartment_7660", "id": "reaction_10546368", "reactome": "R-CEL-3108212", "name": "SMC5-SMC6 Complex SUMOylates Cohesin with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10544476", "species_10546081" ], "products": [ "species_10546332", "species_10546073" ], "modifiers": [ [ "species_10546365", "catalyst" ] ], "additional_components": [ "B2FDA8", "WBGene00004873", "Q19325", "WBGene00004737", "Q9XUB3", "WBGene00004333", "Q19555", "WBGene00004738", "O01789", "WBGene00001860", "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "B2FDA8", "WBGene00004873", "Q19325", "WBGene00004737", "Q9XUB3", "WBGene00004333", "P55853", "WBGene00004888", "Q19555", "WBGene00004738", "O01789", "WBGene00001860", "WBGene00006706", "G5EG17", "WBGene00010056", "P91501", "WBGene00020843", "Q23420", "WBGene00022881", "Q9XTV3", "WBGene00010409", "Q18237", "WBGene00016151" ] }, "reaction_10549336": { "compartment": "compartment_7660", "id": "reaction_10549336", "reactome": "R-CEL-4570554", "name": "SUMOylation of MDC1 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10549326", "species_10546081" ], "products": [ "species_10546073", "species_10549334" ], "modifiers": [ [ "species_10546081", "catalyst" ] ], "additional_components": [ "WBGene00004031", "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "WBGene00006706", "P55853", "WBGene00004888", "Q9U370", "WBGene00004031", "Q95017", "WBGene00006706", "P55853", "WBGene00004888" ] }, "reaction_10549321": { "compartment": "compartment_7660", "id": "reaction_10549321", "reactome": "R-CEL-4570528", "name": "SUMOylation of XPC with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10549311", "species_10546081" ], "products": [ "species_10546073", "species_10549319" ], "modifiers": [ [ "species_10546081", "catalyst" ] ], "additional_components": [ "WBGene00022296", "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "WBGene00006706", "Q9N4C3", "WBGene00022296", "P55853", "WBGene00004888", "Q95017", "WBGene00006706", "P55853", "WBGene00004888" ] }, "reaction_10546235": { "compartment": "compartment_7660", "id": "reaction_10546235", "reactome": "R-CEL-3000383", "name": "UBE2I, HDAC7 SUMOylate PML with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546215", "species_10546081" ], "products": [ "species_10546073", "species_10546225" ], "modifiers": [ [ "species_10546232", "catalyst" ] ], "additional_components": [ "WBGene00006523", "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "WBGene00006706", "G5ED20", "WBGene00006523", "P55853", "WBGene00004888", "O17323", "WBGene00001837", "Q95017", "WBGene00006706" ] }, "reaction_10549243": { "compartment": "compartment_7660", "id": "reaction_10549243", "reactome": "R-CEL-4551661", "name": "PIAS4 SUMOylates RNF168 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546081", "species_10549233" ], "products": [ "species_10546073", "species_10549241" ], "modifiers": [ [ "species_10546168", "catalyst" ] ], "additional_components": [ "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "WBGene00011366", "WBGene00006706", "P55853", "WBGene00004888", "Q7YWU1", "WBGene00011366", "Q21970", "WBGene00011259", "Q94361", "WBGene00001574" ] }, "reaction_10546173": { "compartment": "compartment_7660", "id": "reaction_10546173", "reactome": "R-CEL-2997709", "name": "PIAS1,4 SUMOylates BRCA1 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546154", "species_10546081" ], "products": [ "species_10546073", "species_10546162" ], "modifiers": [ [ "species_10546170", "catalyst" ] ], "additional_components": [ "WBGene00000264", "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "WBGene00006706", "P55853", "WBGene00004888", "B6VQ60", "WBGene00000264", "Q21970", "WBGene00011259", "Q94361", "WBGene00001574" ] }, "reaction_10549255": { "compartment": "compartment_7660", "id": "reaction_10549255", "reactome": "R-CEL-4551721", "name": "PIAS4 SUMOylates VHL with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10532238", "species_10546081" ], "products": [ "species_10546073", "species_10549253" ], "modifiers": [ [ "species_10546168", "catalyst" ] ], "additional_components": [ "WBGene00006922", "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "WBGene00006706", "Q19213", "WBGene00006922", "P55853", "WBGene00004888", "Q21970", "WBGene00011259", "Q94361", "WBGene00001574" ] }, "reaction_10546769": { "compartment": "compartment_7660", "id": "reaction_10546769", "reactome": "R-CEL-3247493", "name": "PIAS1 SUMOylates SP3 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546758", "species_10546081" ], "products": [ "species_10546766", "species_10546073" ], "modifiers": [ [ "species_10528091", "catalyst" ] ], "additional_components": [ "WBGene00012735", "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "Q9XW26", "WBGene00012735", "P55853", "WBGene00004888", "WBGene00006706", "Q21970", "WBGene00011259", "Q94361", "WBGene00001574" ] }, "reaction_10546189": { "compartment": "compartment_7660", "id": "reaction_10546189", "reactome": "R-CEL-2997723", "name": "PIAS4 SUMOylates TP53BP1 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546178", "species_10546081" ], "products": [ "species_10546186", "species_10546073" ], "modifiers": [ [ "species_10546168", "catalyst" ] ], "additional_components": [ "WBGene00002027", "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "Q7JKP6", "WBGene00002027", "P55853", "WBGene00004888", "WBGene00006706", "Q21970", "WBGene00011259", "Q94361", "WBGene00001574" ] }, "reaction_10546734": { "compartment": "compartment_7660", "id": "reaction_10546734", "reactome": "R-CEL-3232162", "name": "PIAS3 SUMOylates MITF with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546716", "species_10546081" ], "products": [ "species_10546073", "species_10546725" ], "modifiers": [ [ "species_10546731", "catalyst" ] ], "additional_components": [ "WBGene00020930", "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "WBGene00006706", "H2KZZ2", "WBGene00020930", "P55853", "WBGene00004888", "Q21970", "WBGene00011259", "Q94361", "WBGene00001574" ] }, "reaction_10549296": { "compartment": "compartment_7660", "id": "reaction_10549296", "reactome": "R-CEL-4570467", "name": "SUMOylation of NOP58 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10549285", "species_10546081" ], "products": [ "species_10549294", "species_10546073" ], "modifiers": [ [ "species_10546081", "catalyst" ] ], "additional_components": [ "WBGene00020915", "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "P55853", "WBGene00004888", "O45012", "WBGene00020915", "WBGene00006706", "Q95017", "WBGene00006706", "P55853", "WBGene00004888" ] }, "reaction_10548368": { "compartment": "compartment_7660", "id": "reaction_10548368", "reactome": "R-CEL-3900177", "name": "SUMOylation of DDX5 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10504695", "species_10546081" ], "products": [ "species_10548366", "species_10546073" ], "modifiers": [ [ "species_10546081", "catalyst" ] ], "additional_components": [ "WBGene00010260", "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "P55853", "WBGene00004888", "Q9XUW5", "WBGene00010260", "WBGene00006706", "Q95017", "WBGene00006706", "P55853", "WBGene00004888" ] }, "reaction_10548945": { "compartment": "compartment_7660", "id": "reaction_10548945", "reactome": "R-CEL-4085331", "name": "PIAS2-1 SUMOylates PARK7 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10548932", "species_10546081" ], "products": [ "species_10548940", "species_10546073" ], "modifiers": [ [ "species_10548942", "catalyst" ] ], "additional_components": [ "WBGene00015184", "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "P55853", "WBGene00004888", "P90994", "WBGene00015184", "WBGene00006706", "WBGene00001574" ] }, "reaction_10548961": { "compartment": "compartment_7660", "id": "reaction_10548961", "reactome": "R-CEL-4085347", "name": "PIAS1 SUMOylates SAFB with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10548950", "species_10546081" ], "products": [ "species_10548959", "species_10546073" ], "modifiers": [ [ "species_10528091", "catalyst" ] ], "additional_components": [ "WBGene00009314", "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "P55853", "WBGene00004888", "O62203", "WBGene00009314", "WBGene00006706", "Q21970", "WBGene00011259", "Q94361", "WBGene00001574" ] }, "reaction_10549026": { "compartment": "compartment_7660", "id": "reaction_10549026", "reactome": "R-CEL-4090284", "name": "SUMOylation of HIPK2 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10549016", "species_10546081" ], "products": [ "species_10546073", "species_10549024" ], "modifiers": [ [ "species_10546081", "catalyst" ] ], "additional_components": [ "WBGene00001994", "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "WBGene00006706", "P55853", "WBGene00004888", "Q8MQ70", "WBGene00001994", "Q95017", "WBGene00006706", "P55853", "WBGene00004888" ] }, "reaction_10548179": { "compartment": "compartment_7660", "id": "reaction_10548179", "reactome": "R-CEL-3782535", "name": "TRIM28 SUMOylates TRIM28:ZNF350 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10548151", "species_10546081" ], "products": [ "species_10546073", "species_10548176" ], "modifiers": [ [ "species_10529660", "catalyst" ] ], "additional_components": [ "Q9N5S3", "WBGene00003087", "O46016", "WBGene00013970", "B7WNA2", "WBGene00010264", "Q19418", "WBGene00008762", "H2L008", "WBGene00019960", "Q9BLC4", "WBGene00017406", "O02050", "WBGene00022592", "H2L0K3", "WBGene00003599", "Q19818", "WBGene00003598", "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "WBGene00006706", "Q9N5S3", "WBGene00003087", "O46016", "WBGene00013970", "B7WNA2", "WBGene00010264", "Q19418", "WBGene00008762", "H2L008", "WBGene00019960", "Q9BLC4", "WBGene00017406", "O02050", "WBGene00022592", "Q19818", "WBGene00003598", "H2L0K3", "WBGene00003599", "P55853", "WBGene00004888", "H2L0K3", "WBGene00003599", "Q19818", "WBGene00003598" ] }, "reaction_10548358": { "compartment": "compartment_7660", "id": "reaction_10548358", "reactome": "R-CEL-3900047", "name": "SUMOylation of DDX17 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10548348", "species_10546081" ], "products": [ "species_10546073", "species_10548356" ], "modifiers": [ [ "species_10546081", "catalyst" ] ], "additional_components": [ "WBGene00010260", "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "WBGene00006706", "Q9XUW5", "WBGene00010260", "P55853", "WBGene00004888", "Q95017", "WBGene00006706", "P55853", "WBGene00004888" ] }, "reaction_10548346": { "compartment": "compartment_7660", "id": "reaction_10548346", "reactome": "R-CEL-3899291", "name": "SUMOylation of EP300 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10532228", "species_10546081" ], "products": [ "species_10546073", "species_10548344" ], "modifiers": [ [ "species_10546081", "catalyst" ] ], "additional_components": [ "WBGene00000366", "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "WBGene00006706", "P55853", "WBGene00004888", "P34545", "WBGene00000366", "Q95017", "WBGene00006706", "P55853", "WBGene00004888" ] }, "reaction_10549506": { "compartment": "compartment_7660", "id": "reaction_10549506", "reactome": "R-CEL-4641362", "name": "SUMOylation of TOP1 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10549496", "species_10546081" ], "products": [ "species_10546073", "species_10549504" ], "modifiers": [ [ "species_10546081", "catalyst" ] ], "additional_components": [ "WBGene00006595", "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "WBGene00006706", "O17966", "WBGene00006595", "P55853", "WBGene00004888", "Q95017", "WBGene00006706", "P55853", "WBGene00004888" ] }, "reaction_10549491": { "compartment": "compartment_7660", "id": "reaction_10549491", "reactome": "R-CEL-4641345", "name": "SUMOylation of TOP2B with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10549474", "species_10546081" ], "products": [ "species_10546073", "species_10549489" ], "modifiers": [ [ "species_10546081", "catalyst" ] ], "additional_components": [ "Q23670", "WBGene00010785", "G5ECQ8", "WBGene00022854", "P34534", "WBGene00019884", "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "WBGene00006706", "G5ECQ8", "WBGene00022854", "P34534", "WBGene00019884", "Q23670", "WBGene00010785", "P55853", "WBGene00004888", "Q95017", "WBGene00006706", "P55853", "WBGene00004888" ] }, "reaction_10549460": { "compartment": "compartment_7660", "id": "reaction_10549460", "reactome": "R-CEL-4641342", "name": "SUMOylation of TOP2A with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10549450", "species_10546081" ], "products": [ "species_10546073", "species_10549458" ], "modifiers": [ [ "species_10546081", "catalyst" ] ], "additional_components": [ "WBGene00019884", "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "WBGene00006706", "P55853", "WBGene00004888", "P34534", "WBGene00019884", "Q95017", "WBGene00006706", "P55853", "WBGene00004888" ] }, "reaction_10549415": { "compartment": "compartment_7660", "id": "reaction_10549415", "reactome": "R-CEL-4615910", "name": "SUMOylation of PCNA with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502651", "species_10546081" ], "products": [ "species_10546073", "species_10549413" ], "modifiers": [ [ "species_10546081", "catalyst" ] ], "additional_components": [ "WBGene00003955", "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "WBGene00006706", "O02115", "WBGene00003955", "P55853", "WBGene00004888", "Q95017", "WBGene00006706", "P55853", "WBGene00004888" ] }, "reaction_10548917": { "compartment": "compartment_7660", "id": "reaction_10548917", "reactome": "R-CEL-3968362", "name": "SUMOylation of PIAS4 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546168", "species_10546081" ], "products": [ "species_10546073", "species_10548915" ], "modifiers": [ [ "species_10546081", "catalyst" ] ], "additional_components": [ "Q21970", "WBGene00011259", "Q94361", "WBGene00001574", "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "WBGene00006706", "Q21970", "WBGene00011259", "Q94361", "WBGene00001574", "P55853", "WBGene00004888", "Q95017", "WBGene00006706", "P55853", "WBGene00004888" ] }, "reaction_10548971": { "compartment": "compartment_7660", "id": "reaction_10548971", "reactome": "R-CEL-4085350", "name": "SUMOylation of UBE2I with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546073", "species_10546081" ], "products": [ "species_10546073", "species_10548969" ], "modifiers": [ [ "species_10546081", "catalyst" ] ], "additional_components": [ "WBGene00006706", "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "WBGene00006706", "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "Q95017", "WBGene00006706", "P55853", "WBGene00004888" ] }, "reaction_10546255": { "compartment": "compartment_13231", "id": "reaction_10546255", "reactome": "R-CEL-3000449", "name": "UBC9 (UBE2I) SUMOylates RANGAP1 with SUMO, which targets RANGAP1 to RANBP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546242", "species_10546081" ], "products": [ "species_10546252", "species_10546073" ], "modifiers": [ [ "species_10546081", "catalyst" ] ], "additional_components": [ "P34342", "WBGene00004303", "Q95017", "WBGene00006706", "P55853", "WBGene00004888", "P34342", "WBGene00004303", "P55853", "WBGene00004888", "WBGene00006706", "Q95017", "WBGene00006706", "P55853", "WBGene00004888" ] }, "reaction_10509888": { "compartment": "compartment_70101", "id": "reaction_10509888", "reactome": "R-CEL-156808", "name": "Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a 'closed-loop' conformation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10505614", "species_10509884", "species_10509879", "species_10505637" ], "products": [ "species_10505614", "species_10509886" ], "modifiers": [], "additional_components": [ "WBGene00019162", "WBGene00003902", "A0A486WX07", "WBGene00002066", "Q20935", "WBGene00018997", "P27639", "WBGene00002083", "O61955", "WBGene00002061", "H2L0A8", "WBGene00019157", "species_29438", "Q9BKU3", "WBGene00021351", "Q21230", "WBGene00010560", "Q95XR0", "WBGene00021466", "P51403", "WBGene00004471", "Q9NEN6", "WBGene00004475", "Q8WQA8", "WBGene00004489", "Q23312", "WBGene00004476", "O01869", "WBGene00004479", "P49197", "WBGene00004490", "P48156", "WBGene00004477", "Q20206", "WBGene00004480", "Q19877", "WBGene00004492", "Q20228", "WBGene00004478", "P49196", "WBGene00004481", "Q1XFY9", "WBGene00004493", "P46769", "WBGene00004469", "P51404", "WBGene00004482", "P52821", "WBGene00004494", "Q9TXP0", "WBGene00004496", "P48150", "WBGene00004483", "O45499", "WBGene00004495", "Q9N3X2", "WBGene00004473", "Q9XVP0", "WBGene00004484", "Q95Y04", "WBGene00004497", "Q22054", "WBGene00004485", "P90983", "WBGene00004498", "O01692", "WBGene00004486", "P48152", "WBGene00004472", "O18240", "WBGene00004487", "O18650", "WBGene00004488", "P48154", "WBGene00004470", "O17218", "WBGene00004491", "P49041", "WBGene00004474", "Q95QW0", "WBGene00015920", "O01974", "WBGene00001231", "Q94261", "WBGene00019543", "P34339", "WBGene00001209", "Q9XWP7", "WBGene00012738", "P30642", "WBGene00001227", "Q965S8", "WBGene00001232", "O02328", "WBGene00001226", "Q19706", "WBGene00001230", "O61820", "WBGene00001228", "Q18967", "WBGene00001229", "Q9XUP3", "WBGene00001233", "Q9XWI6", "WBGene00001225", "Q9TXU7", "WBGene00019162", "WBGene00019162", "A0A486WX07", "WBGene00002066", "Q20935", "WBGene00018997", "P27639", "WBGene00002083", "O61955", "WBGene00002061", "species_29438", "Q9BKU3", "WBGene00021351", "Q21230", "WBGene00010560", "Q95XR0", "WBGene00021466", "P51403", "WBGene00004471", "Q9NEN6", "WBGene00004475", "Q8WQA8", "WBGene00004489", "Q23312", "WBGene00004476", "O01869", "WBGene00004479", "P49197", "WBGene00004490", "P48156", "WBGene00004477", "Q20206", "WBGene00004480", "Q19877", "WBGene00004492", "Q20228", "WBGene00004478", "P49196", "WBGene00004481", "Q1XFY9", "WBGene00004493", "P46769", "WBGene00004469", "P51404", "WBGene00004482", "P52821", "WBGene00004494", "Q9TXP0", "WBGene00004496", "P48150", "WBGene00004483", "O45499", "WBGene00004495", "Q9N3X2", "WBGene00004473", "Q9XVP0", "WBGene00004484", "Q95Y04", "WBGene00004497", "Q22054", "WBGene00004485", "P90983", "WBGene00004498", "O01692", "WBGene00004486", "P48152", "WBGene00004472", "O18240", "WBGene00004487", "O18650", "WBGene00004488", "P48154", "WBGene00004470", "O17218", "WBGene00004491", "P49041", "WBGene00004474", "Q95QW0", "WBGene00015920", "O01974", "WBGene00001231", "Q94261", "WBGene00019543", "P34339", "WBGene00001209", "Q9XWP7", "WBGene00012738", "P30642", "WBGene00001227", "Q965S8", "WBGene00001232", "O02328", "WBGene00001226", "Q19706", "WBGene00001230", "O61820", "WBGene00001228", "Q18967", "WBGene00001229", "Q9XUP3", "WBGene00001233", "Q9XWI6", "WBGene00001225", "Q9TXU7", "WBGene00019162", "H2L0A8", "WBGene00019157", "Q9U302", "WBGene00003902" ] }, "reaction_10509927": { "compartment": "compartment_70101", "id": "reaction_10509927", "reactome": "R-CEL-157849", "name": "Formation of translation initiation complexes containing mRNA that does not circularize", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10505614", "species_10509925", "species_10505637" ], "products": [ "species_10505614", "species_10505676" ], "modifiers": [], "additional_components": [ "WBGene00019162", "A0A486WX07", "WBGene00002066", "Q20935", "WBGene00018997", "P27639", "WBGene00002083", "O61955", "WBGene00002061", "H2L0A8", "WBGene00019157", "species_29438", "Q9BKU3", "WBGene00021351", "Q21230", "WBGene00010560", "Q95XR0", "WBGene00021466", "P51403", "WBGene00004471", "Q9NEN6", "WBGene00004475", "Q8WQA8", "WBGene00004489", "Q23312", "WBGene00004476", "O01869", "WBGene00004479", "P49197", "WBGene00004490", "P48156", "WBGene00004477", "Q20206", "WBGene00004480", "Q19877", "WBGene00004492", "Q20228", "WBGene00004478", "P49196", "WBGene00004481", "Q1XFY9", "WBGene00004493", "P46769", "WBGene00004469", "P51404", "WBGene00004482", "P52821", "WBGene00004494", "Q9TXP0", "WBGene00004496", "P48150", "WBGene00004483", "O45499", "WBGene00004495", "Q9N3X2", "WBGene00004473", "Q9XVP0", "WBGene00004484", "Q95Y04", "WBGene00004497", "Q22054", "WBGene00004485", "P90983", "WBGene00004498", "O01692", "WBGene00004486", "P48152", "WBGene00004472", "O18240", "WBGene00004487", "O18650", "WBGene00004488", "P48154", "WBGene00004470", "O17218", "WBGene00004491", "P49041", "WBGene00004474", "Q95QW0", "WBGene00015920", "O01974", "WBGene00001231", "Q94261", "WBGene00019543", "P34339", "WBGene00001209", "Q9XWP7", "WBGene00012738", "P30642", "WBGene00001227", "Q965S8", "WBGene00001232", "O02328", "WBGene00001226", "Q19706", "WBGene00001230", "O61820", "WBGene00001228", "Q18967", "WBGene00001229", "Q9XUP3", "WBGene00001233", "Q9XWI6", "WBGene00001225", "Q9TXU7", "WBGene00019162", "WBGene00019162", "A0A486WX07", "WBGene00002066", "Q20935", "WBGene00018997", "P27639", "WBGene00002083", "O61955", "WBGene00002061", "species_29438", "Q9BKU3", "WBGene00021351", "Q21230", "WBGene00010560", "Q95XR0", "WBGene00021466", "P51403", "WBGene00004471", "Q9NEN6", "WBGene00004475", "Q8WQA8", "WBGene00004489", "Q23312", "WBGene00004476", "O01869", "WBGene00004479", "P49197", "WBGene00004490", "P48156", "WBGene00004477", "Q20206", "WBGene00004480", "Q19877", "WBGene00004492", "Q20228", "WBGene00004478", "P49196", "WBGene00004481", "Q1XFY9", "WBGene00004493", "P46769", "WBGene00004469", "P51404", "WBGene00004482", "P52821", "WBGene00004494", "Q9TXP0", "WBGene00004496", "P48150", "WBGene00004483", "O45499", "WBGene00004495", "Q9N3X2", "WBGene00004473", "Q9XVP0", "WBGene00004484", "Q95Y04", "WBGene00004497", "Q22054", "WBGene00004485", "P90983", "WBGene00004498", "O01692", "WBGene00004486", "P48152", "WBGene00004472", "O18240", "WBGene00004487", "O18650", "WBGene00004488", "P48154", "WBGene00004470", "O17218", "WBGene00004491", "P49041", "WBGene00004474", "Q95QW0", "WBGene00015920", "O01974", "WBGene00001231", "Q94261", "WBGene00019543", "P34339", "WBGene00001209", "Q9XWP7", "WBGene00012738", "P30642", "WBGene00001227", "Q965S8", "WBGene00001232", "O02328", "WBGene00001226", "Q19706", "WBGene00001230", "O61820", "WBGene00001228", "Q18967", "WBGene00001229", "Q9XUP3", "WBGene00001233", "Q9XWI6", "WBGene00001225", "Q9TXU7", "WBGene00019162", "H2L0A8", "WBGene00019157" ] }, "reaction_10549921": { "compartment": "compartment_876", "id": "reaction_10549921", "reactome": "R-CEL-5138441", "name": "WNT5A-FZD4 recruits DVL2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10549898", "species_10515048" ], "products": [ "species_10549902" ], "modifiers": [], "additional_components": [ "Q9N532", "WBGene00003238", "G5EDV1", "WBGene00003006", "P34889", "WBGene00000858", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "Q9N532", "WBGene00003238", "G5EDV1", "WBGene00003006", "P34889", "WBGene00000858" ] }, "reaction_10549909": { "compartment": "compartment_876", "id": "reaction_10549909", "reactome": "R-CEL-5138432", "name": "DVL2 is phosphorylated by PKC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10549902", "species_113592" ], "products": [ "species_29370", "species_10549904" ], "modifiers": [ [ "species_10549906", "catalyst" ] ], "additional_components": [ "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "Q9N532", "WBGene00003238", "G5EDV1", "WBGene00003006", "P34889", "WBGene00000858", "Q9N532", "WBGene00003238", "G5EDV1", "WBGene00003006", "P34889", "WBGene00000858", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241" ] }, "reaction_10549900": { "compartment": "compartment_876", "id": "reaction_10549900", "reactome": "R-CEL-5099899", "name": "WNT5A binds FZD4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546954", "species_10548869" ], "products": [ "species_10549898" ], "modifiers": [], "additional_components": [ "WBGene00000858", "Q9N532", "WBGene00003238", "G5EDV1", "WBGene00003006", "Q9N532", "WBGene00003238", "G5EDV1", "WBGene00003006", "P34889", "WBGene00000858" ] }, "reaction_10549919": { "compartment": "compartment_876", "id": "reaction_10549919", "reactome": "R-CEL-5138433", "name": "p-DVL2 recruits AP-2 and beta-arrestin 2 to promote clathrin-mediated endocytosis", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10521727", "species_10549913", "species_10549904" ], "products": [ "species_10549917" ], "modifiers": [], "additional_components": [ "WBGene00000195", "P34574", "WBGene00011867", "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q9N532", "WBGene00003238", "G5EDV1", "WBGene00003006", "P34889", "WBGene00000858", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "P34574", "WBGene00011867", "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q9N532", "WBGene00003238", "G5EDV1", "WBGene00003006", "P34889", "WBGene00000858", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "P51485", "WBGene00000195" ] }, "reaction_10549967": { "compartment": "compartment_20592", "id": "reaction_10549967", "reactome": "R-CEL-5138459", "name": "WNT5A:FZD4 is endocytosed", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10549917" ], "products": [ "species_10521727", "species_10549965" ], "modifiers": [], "additional_components": [ "P34574", "WBGene00011867", "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q9N532", "WBGene00003238", "G5EDV1", "WBGene00003006", "P34889", "WBGene00000858", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "P51485", "WBGene00000195", "WBGene00000195", "Q9N4F3", "WBGene00000160", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q22601", "WBGene00000161", "P34574", "WBGene00011867", "P34889", "WBGene00000858", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "G5EDV1", "WBGene00003006", "Q9N532", "WBGene00003238" ] }, "reaction_10548310": { "compartment": "compartment_876", "id": "reaction_10548310", "reactome": "R-CEL-3858482", "name": "DVL is recruited to the receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10548306", "species_10548304" ], "products": [ "species_10548308" ], "modifiers": [], "additional_components": [ "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "A0A0K3AWM6", "T23D8.1b", "Q27886", "WBGene00003029", "Q10459", "WBGene00003395", "A0A0K3AWM6", "T23D8.1b", "Q27886", "WBGene00003029", "Q10459", "WBGene00003395", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241" ] }, "reaction_10548294": { "compartment": "compartment_70101", "id": "reaction_10548294", "reactome": "R-CEL-3858475", "name": "ppDVL recruits RAC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10548290", "species_10548288" ], "products": [ "species_10548292" ], "modifiers": [], "additional_components": [ "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "Q03206", "ced-10", "species_29438", "Q03206", "ced-10", "species_29438", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241" ] }, "reaction_10549994": { "compartment": "compartment_20592", "id": "reaction_10549994", "reactome": "R-CEL-5140747", "name": "FZD2, FZD5 and ROR2 are internalized in a WNT5A and clathrin-dependent manner", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10549978" ], "products": [ "species_10549992" ], "modifiers": [ [ "species_10549913", "catalyst" ] ], "additional_components": [ "G5EGK5", "WBGene00000289", "A0A0K3AWM6", "T23D8.1b", "G5ECQ2", "WBGene00000478", "P34889", "WBGene00000858", "P34889", "WBGene00000858", "G5ECQ2", "WBGene00000478", "G5EGK5", "WBGene00000289", "A0A0K3AWM6", "T23D8.1b", "P34574", "WBGene00011867", "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "P35603", "WBGene00001082", "Q19123", "WBGene00000157" ] }, "reaction_10549980": { "compartment": "compartment_876", "id": "reaction_10549980", "reactome": "R-CEL-5140741", "name": "WNT5A binds FZD and ROR receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546954", "species_10549976" ], "products": [ "species_10549978" ], "modifiers": [], "additional_components": [ "WBGene00000858", "G5EGK5", "WBGene00000289", "A0A0K3AWM6", "T23D8.1b", "G5ECQ2", "WBGene00000478", "G5EGK5", "WBGene00000289", "A0A0K3AWM6", "T23D8.1b", "G5ECQ2", "WBGene00000478", "P34889", "WBGene00000858" ] }, "reaction_10549896": { "compartment": "compartment_876", "id": "reaction_10549896", "reactome": "R-CEL-5099886", "name": "WNT5A binding to FZD promotes PRICKLE1 degradation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546954", "species_10549892" ], "products": [ "species_10549894" ], "modifiers": [], "additional_components": [ "WBGene00000858", "G5ECQ2", "WBGene00000478", "G5ECQ2", "WBGene00000478", "P34889", "WBGene00000858" ] }, "reaction_10549370": { "compartment": "compartment_70101", "id": "reaction_10549370", "reactome": "R-CEL-4608855", "name": "PRICKLE1 is degraded by the proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10549368" ], "products": [], "modifiers": [ [ "species_10502572", "catalyst" ] ], "additional_components": [ "H2KYA1", "WBGene00022727", "H2KZA3", "WBGene00004112", "Q17525", "WBGene00015217", "P91477", "WBGene00003950", "Q95PZ7", "WBGene00013435", "Q18115", "WBGene00004459", "O62102", "WBGene00003948", "O17071", "WBGene00004504", "Q10920", "WBGene00016623", "P34286", "WBGene00003952", "Q9XTT9", "WBGene00004506", "Q23449", "WBGene00004468", "Q95005", "WBGene00003925", "P46502", "WBGene00004503", "O61792", "WBGene00004464", "O17586", "WBGene00003922", "O76371", "WBGene00004505", "Q20585", "WBGene00004463", "Q95008", "WBGene00003926", "Q18787", "WBGene00004501", "Q20058", "WBGene00009445", "Q9N599", "WBGene00003924", "O16368", "WBGene00004502", "O61742", "WBGene00004466", "Q09583", "WBGene00003928", "Q966I8", "WBGene00003947", "Q04908", "WBGene00004460", "Q9XUV0", "WBGene00003951", "Q27488", "WBGene00003923", "Q9GZH5", "WBGene00004458", "O44156", "WBGene00003927", "Q22253", "WBGene00004465", "O76577", "WBGene00004467", "P90868", "WBGene00003953", "Q19324", "WBGene00004461", "Q17971", "WBGene00007588", "Q23237", "WBGene00003949", "Q20938", "WBGene00004462" ] }, "reaction_10567373": { "compartment": "compartment_876", "id": "reaction_10567373", "reactome": "R-CEL-8875661", "name": "GGA3 associates with activated MET receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10565510", "species_10565557", "species_10567330" ], "products": [ "species_10567371" ], "modifiers": [], "additional_components": [ "WBGene00000166", "Q9U2S4", "WBGene00000184", "species_29438", "G5EDJ4", "WBGene00004928", "Q9XVQ7", "WBGene00008711", "P29355", "WBGene00004774", "Q9NHC3", "WBGene00000416", "Q95XA9", "WBGene00021238", "G5EDJ4", "WBGene00004928", "Q9XVQ7", "WBGene00008711", "P29355", "WBGene00004774", "Q9NHC3", "WBGene00000416", "Q95XA9", "WBGene00021238", "Q9U2S4", "WBGene00000184", "species_29438", "Q23165", "WBGene00000166" ] }, "reaction_10515028": { "compartment": "compartment_876", "id": "reaction_10515028", "reactome": "R-CEL-201677", "name": "Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10515006", "species_113592" ], "products": [ "species_29370", "species_10515025" ], "modifiers": [ [ "species_10515006", "catalyst" ] ], "additional_components": [ "A0A0K3AWM6", "T23D8.1b", "G5EBV9", "WBGene00020481", "Q22179", "WBGene00003075", "Q7JP80", "WBGene00020481", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "Q9U2Q9", "WBGene00001746", "Q09595", "WBGene00010991", "Q93372", "WBGene00010991", "O62090", "WBGene00004202", "A0A0K3AWM6", "T23D8.1b", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "Q9U2Q9", "WBGene00001746", "Q09595", "WBGene00010991", "Q93372", "WBGene00010991", "O62090", "WBGene00004202", "G5EBV9", "WBGene00020481", "Q22179", "WBGene00003075", "Q7JP80", "WBGene00020481", "A0A0K3AWM6", "T23D8.1b", "G5EBV9", "WBGene00020481", "Q22179", "WBGene00003075", "Q7JP80", "WBGene00020481", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "Q9U2Q9", "WBGene00001746", "Q09595", "WBGene00010991", "Q93372", "WBGene00010991", "O62090", "WBGene00004202" ] }, "reaction_10535159": { "compartment": "compartment_70101", "id": "reaction_10535159", "reactome": "R-CEL-1504186", "name": "DVL recruits GSK3beta:AXIN1 to the receptor complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10514942", "species_10515004" ], "products": [ "species_10515006" ], "modifiers": [], "additional_components": [ "Q9U2Q9", "WBGene00001746", "Q09595", "WBGene00010991", "Q93372", "WBGene00010991", "O62090", "WBGene00004202", "A0A0K3AWM6", "T23D8.1b", "G5EBV9", "WBGene00020481", "Q22179", "WBGene00003075", "Q7JP80", "WBGene00020481", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "A0A0K3AWM6", "T23D8.1b", "G5EBV9", "WBGene00020481", "Q22179", "WBGene00003075", "Q7JP80", "WBGene00020481", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "Q9U2Q9", "WBGene00001746", "Q09595", "WBGene00010991", "Q93372", "WBGene00010991", "O62090", "WBGene00004202" ] }, "reaction_10551830": { "compartment": "compartment_876", "id": "reaction_10551830", "reactome": "R-CEL-5368596", "name": "WNT3A stimulates the caveolin-dependent internalization of FZD5:p-LRP6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10551808" ], "products": [ "species_10551828" ], "modifiers": [], "additional_components": [ "G5ECQ2", "WBGene00000478", "Q18879", "WBGene00000302", "Q94051", "WBGene00000301", "Q9U2Q9", "WBGene00001746", "Q09595", "WBGene00010991", "Q93372", "WBGene00010991", "O62090", "WBGene00004202", "G5EBV9", "WBGene00020481", "Q22179", "WBGene00003075", "Q7JP80", "WBGene00020481", "Q7JP80", "WBGene00020481", "G5EBV9", "WBGene00020481", "Q22179", "WBGene00003075", "Q18879", "WBGene00000302", "Q94051", "WBGene00000301", "G5ECQ2", "WBGene00000478", "Q9U2Q9", "WBGene00001746", "Q09595", "WBGene00010991", "Q93372", "WBGene00010991", "O62090", "WBGene00004202" ] }, "reaction_10507606": { "compartment": "compartment_7660", "id": "reaction_10507606", "reactome": "R-CEL-75949", "name": "RNA Polymerase II Promoter Opening: First Transition", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10507432" ], "products": [ "species_113550", "species_113582", "species_10507424" ], "modifiers": [ [ "species_10506316", "catalyst" ] ], "additional_components": [ "G5EG49", "WBGene00013998", "G5EG47", "WBGene00010054", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q95ZS0", "WBGene00006392", "Q9GZI6", "WBGene00006387", "G5EF68", "WBGene00006386", "O45784", "WBGene00006391", "P32085", "WBGene00006542", "O61707", "WBGene00006385", "Q9NEW8", "WBGene00006389", "Q9TYN3", "WBGene00006383", "Q18265", "WBGene00016173", "Q17957", "WBGene00006397", "E9P861", "WBGene00006384", "Q20361", "WBGene00006395", "G5EGM3", "WBGene00006382", "O44625", "WBGene00004136", "Q9NEX2", "WBGene00013736", "O16991", "WBGene00006648", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "G5EG49", "WBGene00013998", "G5EG47", "WBGene00010054", "O44625", "WBGene00004136", "Q9NEX2", "WBGene00013736", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q95ZS0", "WBGene00006392", "Q9GZI6", "WBGene00006387", "G5EF68", "WBGene00006386", "O45784", "WBGene00006391", "P32085", "WBGene00006542", "O61707", "WBGene00006385", "Q9NEW8", "WBGene00006389", "Q9TYN3", "WBGene00006383", "Q18265", "WBGene00016173", "Q17957", "WBGene00006397", "E9P861", "WBGene00006384", "Q20361", "WBGene00006395", "G5EGM3", "WBGene00006382", "O16991", "WBGene00006648", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529" ] }, "reaction_10507459": { "compartment": "compartment_7660", "id": "reaction_10507459", "reactome": "R-CEL-75873", "name": "Addition of Nucleotides 5 through 9 on the growing Transcript", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30595", "species_10507442" ], "products": [ "species_113541", "species_10506516", "species_10506433", "species_10507457", "species_10506528" ], "modifiers": [ [ "species_10504433", "catalyst" ] ], "additional_components": [ "species_110614", "species_29358", "species_29494", "species_29438", "G5EG49", "WBGene00013998", "G5EG47", "WBGene00010054", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "O44625", "WBGene00004136", "Q9NEX2", "WBGene00013736", "Q95ZS0", "WBGene00006392", "Q9GZI6", "WBGene00006387", "G5EF68", "WBGene00006386", "O45784", "WBGene00006391", "P32085", "WBGene00006542", "O61707", "WBGene00006385", "Q9NEW8", "WBGene00006389", "Q9TYN3", "WBGene00006383", "Q18265", "WBGene00016173", "Q17957", "WBGene00006397", "E9P861", "WBGene00006384", "Q20361", "WBGene00006395", "G5EGM3", "WBGene00006382", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q95ZS0", "WBGene00006392", "Q9GZI6", "WBGene00006387", "G5EF68", "WBGene00006386", "O45784", "WBGene00006391", "P32085", "WBGene00006542", "O61707", "WBGene00006385", "Q9NEW8", "WBGene00006389", "Q9TYN3", "WBGene00006383", "Q18265", "WBGene00016173", "Q17957", "WBGene00006397", "E9P861", "WBGene00006384", "Q20361", "WBGene00006395", "G5EGM3", "WBGene00006382", "O44625", "WBGene00004136", "Q9NEX2", "WBGene00013736", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "G5EG49", "WBGene00013998", "G5EG47", "WBGene00010054", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140" ] }, "reaction_10507444": { "compartment": "compartment_7660", "id": "reaction_10507444", "reactome": "R-CEL-75869", "name": "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30595", "species_10507394" ], "products": [ "species_10506438", "species_113541", "species_10507442" ], "modifiers": [ [ "species_10504433", "catalyst" ] ], "additional_components": [ "species_110614", "species_29358", "species_29494", "species_29438", "G5EG49", "WBGene00013998", "G5EG47", "WBGene00010054", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "O44625", "WBGene00004136", "Q9NEX2", "WBGene00013736", "Q95ZS0", "WBGene00006392", "Q9GZI6", "WBGene00006387", "G5EF68", "WBGene00006386", "O45784", "WBGene00006391", "P32085", "WBGene00006542", "O61707", "WBGene00006385", "Q9NEW8", "WBGene00006389", "Q9TYN3", "WBGene00006383", "Q18265", "WBGene00016173", "Q17957", "WBGene00006397", "E9P861", "WBGene00006384", "Q20361", "WBGene00006395", "G5EGM3", "WBGene00006382", "O16991", "WBGene00006648", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "WBGene00006648", "G5EG49", "WBGene00013998", "G5EG47", "WBGene00010054", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "O44625", "WBGene00004136", "Q9NEX2", "WBGene00013736", "Q95ZS0", "WBGene00006392", "Q9GZI6", "WBGene00006387", "G5EF68", "WBGene00006386", "O45784", "WBGene00006391", "P32085", "WBGene00006542", "O61707", "WBGene00006385", "Q9NEW8", "WBGene00006389", "Q9TYN3", "WBGene00006383", "Q18265", "WBGene00016173", "Q17957", "WBGene00006397", "E9P861", "WBGene00006384", "Q20361", "WBGene00006395", "G5EGM3", "WBGene00006382", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140" ] }, "reaction_10508100": { "compartment": "compartment_7660", "id": "reaction_10508100", "reactome": "R-CEL-76576", "name": "Addition of nucleotides 10 and 11 on the growing transcript: Third Transition", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30595", "species_10507457" ], "products": [ "species_113541", "species_10508098" ], "modifiers": [ [ "species_10504433", "catalyst" ] ], "additional_components": [ "species_110614", "species_29358", "species_29494", "species_29438", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140" ] }, "reaction_10507397": { "compartment": "compartment_7660", "id": "reaction_10507397", "reactome": "R-CEL-75850", "name": "Addition of the third nucleotide on the nascent transcript", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30595", "species_10506530" ], "products": [ "species_113541", "species_10507394" ], "modifiers": [ [ "species_10504433", "catalyst" ] ], "additional_components": [ "species_110614", "species_29358", "species_29494", "species_29438", "G5EG49", "WBGene00013998", "G5EG47", "WBGene00010054", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "O44625", "WBGene00004136", "Q9NEX2", "WBGene00013736", "Q95ZS0", "WBGene00006392", "Q9GZI6", "WBGene00006387", "G5EF68", "WBGene00006386", "O45784", "WBGene00006391", "P32085", "WBGene00006542", "O61707", "WBGene00006385", "Q9NEW8", "WBGene00006389", "Q9TYN3", "WBGene00006383", "Q18265", "WBGene00016173", "Q17957", "WBGene00006397", "E9P861", "WBGene00006384", "Q20361", "WBGene00006395", "G5EGM3", "WBGene00006382", "O16991", "WBGene00006648", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "G5EG49", "WBGene00013998", "G5EG47", "WBGene00010054", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "O44625", "WBGene00004136", "Q9NEX2", "WBGene00013736", "Q95ZS0", "WBGene00006392", "Q9GZI6", "WBGene00006387", "G5EF68", "WBGene00006386", "O45784", "WBGene00006391", "P32085", "WBGene00006542", "O61707", "WBGene00006385", "Q9NEW8", "WBGene00006389", "Q9TYN3", "WBGene00006383", "Q18265", "WBGene00016173", "Q17957", "WBGene00006397", "E9P861", "WBGene00006384", "Q20361", "WBGene00006395", "G5EGM3", "WBGene00006382", "O16991", "WBGene00006648", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140" ] }, "reaction_10572134": { "compartment": "compartment_7660", "id": "reaction_10572134", "reactome": "R-CEL-9613494", "name": "Unwinding of DNA for the Nascent Transcript: Second Transition", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10507394" ], "products": [ "species_164121", "species_113541", "species_10507394" ], "modifiers": [ [ "species_10506316", "catalyst" ] ], "additional_components": [ "G5EG49", "WBGene00013998", "G5EG47", "WBGene00010054", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "O44625", "WBGene00004136", "Q9NEX2", "WBGene00013736", "Q95ZS0", "WBGene00006392", "Q9GZI6", "WBGene00006387", "G5EF68", "WBGene00006386", "O45784", "WBGene00006391", "P32085", "WBGene00006542", "O61707", "WBGene00006385", "Q9NEW8", "WBGene00006389", "Q9TYN3", "WBGene00006383", "Q18265", "WBGene00016173", "Q17957", "WBGene00006397", "E9P861", "WBGene00006384", "Q20361", "WBGene00006395", "G5EGM3", "WBGene00006382", "O16991", "WBGene00006648", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "G5EG49", "WBGene00013998", "G5EG47", "WBGene00010054", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "O44625", "WBGene00004136", "Q9NEX2", "WBGene00013736", "Q95ZS0", "WBGene00006392", "Q9GZI6", "WBGene00006387", "G5EF68", "WBGene00006386", "O45784", "WBGene00006391", "P32085", "WBGene00006542", "O61707", "WBGene00006385", "Q9NEW8", "WBGene00006389", "Q9TYN3", "WBGene00006383", "Q18265", "WBGene00016173", "Q17957", "WBGene00006397", "E9P861", "WBGene00006384", "Q20361", "WBGene00006395", "G5EGM3", "WBGene00006382", "O16991", "WBGene00006648", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529" ] }, "reaction_10572136": { "compartment": "compartment_7660", "id": "reaction_10572136", "reactome": "R-CEL-9613497", "name": "Unwinding DNA for the nascent transcript", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30595", "species_10506530" ], "products": [ "species_113541", "species_10506530" ], "modifiers": [ [ "species_10506316", "catalyst" ] ], "additional_components": [ "species_110614", "species_29358", "species_29494", "species_29438", "G5EG49", "WBGene00013998", "G5EG47", "WBGene00010054", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "O44625", "WBGene00004136", "Q9NEX2", "WBGene00013736", "Q95ZS0", "WBGene00006392", "Q9GZI6", "WBGene00006387", "G5EF68", "WBGene00006386", "O45784", "WBGene00006391", "P32085", "WBGene00006542", "O61707", "WBGene00006385", "Q9NEW8", "WBGene00006389", "Q9TYN3", "WBGene00006383", "Q18265", "WBGene00016173", "Q17957", "WBGene00006397", "E9P861", "WBGene00006384", "Q20361", "WBGene00006395", "G5EGM3", "WBGene00006382", "O16991", "WBGene00006648", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "G5EG49", "WBGene00013998", "G5EG47", "WBGene00010054", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "O44625", "WBGene00004136", "Q9NEX2", "WBGene00013736", "Q95ZS0", "WBGene00006392", "Q9GZI6", "WBGene00006387", "G5EF68", "WBGene00006386", "O45784", "WBGene00006391", "P32085", "WBGene00006542", "O61707", "WBGene00006385", "Q9NEW8", "WBGene00006389", "Q9TYN3", "WBGene00006383", "Q18265", "WBGene00016173", "Q17957", "WBGene00006397", "E9P861", "WBGene00006384", "Q20361", "WBGene00006395", "G5EGM3", "WBGene00006382", "O16991", "WBGene00006648", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529" ] }, "reaction_10508830": { "compartment": "compartment_7660", "id": "reaction_10508830", "reactome": "R-CEL-111264", "name": "Addition of nucleotides between position +11 and +30", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30595", "species_10508098" ], "products": [ "species_10508135", "species_113541" ], "modifiers": [ [ "species_10504433", "catalyst" ] ], "additional_components": [ "species_110614", "species_29358", "species_29494", "species_29438", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140" ] }, "reaction_10547360": { "compartment": "compartment_70101", "id": "reaction_10547360", "reactome": "R-CEL-3322016", "name": "GBE1 catalyzes branch formation in polyGlc-GYG2 complexed with GYS2-a", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10547348" ], "products": [ "species_10547358" ], "modifiers": [ [ "species_10547328", "catalyst" ] ], "additional_components": [ "Q9U2D9", "WBGene00001793", "species_114632", "G5ECZ5", "WBGene00011684", "H2KYQ5", "WBGene00006863", "O45819", "WBGene00012020", "Q9U2D9", "WBGene00001793", "species_114632", "H2KYQ5", "WBGene00006863", "O45819", "WBGene00012020", "G5ECZ5", "WBGene00011684", "WBGene00011409" ] }, "reaction_10547331": { "compartment": "compartment_70101", "id": "reaction_10547331", "reactome": "R-CEL-3322005", "name": "GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-a", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10547303" ], "products": [ "species_10547323" ], "modifiers": [ [ "species_10547328", "catalyst" ] ], "additional_components": [ "Q9U2D9", "WBGene00001793", "species_114632", "H2KYQ5", "WBGene00006863", "Q9U2D9", "WBGene00001793", "species_114632", "H2KYQ5", "WBGene00006863", "WBGene00011409" ] }, "reaction_10547369": { "compartment": "compartment_70101", "id": "reaction_10547369", "reactome": "R-CEL-3322019", "name": "Autoglucosylation of GYG2 complexed with GYS2-b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10547364", "species_29410" ], "products": [ "species_10547366", "species_110096" ], "modifiers": [ [ "species_10547364", "catalyst" ] ], "additional_components": [ "Q9U2D9", "WBGene00001793", "species_114632", "G5ECZ5", "WBGene00011684", "H2KYQ5", "WBGene00006863", "O45819", "WBGene00012020", "G5ECZ5", "WBGene00011684", "H2KYQ5", "WBGene00006863", "O45819", "WBGene00012020", "Q9U2D9", "WBGene00001793", "species_114632", "Q9U2D9", "WBGene00001793", "species_114632", "G5ECZ5", "WBGene00011684", "H2KYQ5", "WBGene00006863", "O45819", "WBGene00012020" ] }, "reaction_10502858": { "compartment": "compartment_70101", "id": "reaction_10502858", "reactome": "R-CEL-70272", "name": "PGM:Mg2+ isomerise G6P to G1P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30537" ], "products": [ "species_29548" ], "modifiers": [ [ "species_10502855", "catalyst" ] ], "additional_components": [ "species_114632", "O45934", "WBGene00012803" ] }, "reaction_10547306": { "compartment": "compartment_70101", "id": "reaction_10547306", "reactome": "R-CEL-3322001", "name": "GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10547301", "species_29410" ], "products": [ "species_10547303", "species_110096" ], "modifiers": [ [ "species_10547301", "catalyst" ] ], "additional_components": [ "Q9U2D9", "WBGene00001793", "H2KYQ5", "WBGene00006863", "species_114632", "Q9U2D9", "WBGene00001793", "species_114632", "H2KYQ5", "WBGene00006863", "Q9U2D9", "WBGene00001793", "H2KYQ5", "WBGene00006863", "species_114632" ] }, "reaction_10547374": { "compartment": "compartment_70101", "id": "reaction_10547374", "reactome": "R-CEL-3322025", "name": "Autoglucosylation of GYG1 complexed with GYS1-a", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10547371", "species_29410" ], "products": [ "species_10547301", "species_110096" ], "modifiers": [ [ "species_10547371", "catalyst" ] ], "additional_components": [ "Q9U2D9", "WBGene00001793", "species_114632", "H2KYQ5", "WBGene00006863", "Q9U2D9", "WBGene00001793", "H2KYQ5", "WBGene00006863", "species_114632", "Q9U2D9", "WBGene00001793", "species_114632", "H2KYQ5", "WBGene00006863" ] }, "reaction_10547379": { "compartment": "compartment_70101", "id": "reaction_10547379", "reactome": "R-CEL-3322041", "name": "Phosphorylated GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10547315", "species_29410" ], "products": [ "species_110096", "species_10547376" ], "modifiers": [ [ "species_10547315", "catalyst" ], [ "species_30537", "catalyst" ] ], "additional_components": [ "H2KYQ5", "WBGene00006863", "species_114632", "Q9U2D9", "WBGene00001793", "species_114632", "H2KYQ5", "WBGene00006863", "Q9U2D9", "WBGene00001793", "H2KYQ5", "WBGene00006863", "species_114632", "Q9U2D9", "WBGene00001793" ] }, "reaction_10547318": { "compartment": "compartment_70101", "id": "reaction_10547318", "reactome": "R-CEL-3322003", "name": "Autoglucosylation of GYG1 complexed with GYS1-b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29410", "species_10547313" ], "products": [ "species_10547315", "species_110096" ], "modifiers": [ [ "species_10547313", "catalyst" ] ], "additional_components": [ "species_114632", "H2KYQ5", "WBGene00006863", "Q9U2D9", "WBGene00001793", "H2KYQ5", "WBGene00006863", "species_114632", "Q9U2D9", "WBGene00001793", "species_114632", "H2KYQ5", "WBGene00006863", "Q9U2D9", "WBGene00001793" ] }, "reaction_10547351": { "compartment": "compartment_70101", "id": "reaction_10547351", "reactome": "R-CEL-3322009", "name": "GYS2 catalyzes the polyglucosylation of oligoGlc-GYG2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10547346", "species_29410" ], "products": [ "species_10547348", "species_110096" ], "modifiers": [ [ "species_10547346", "catalyst" ] ], "additional_components": [ "G5ECZ5", "WBGene00011684", "H2KYQ5", "WBGene00006863", "O45819", "WBGene00012020", "Q9U2D9", "WBGene00001793", "species_114632", "Q9U2D9", "WBGene00001793", "species_114632", "G5ECZ5", "WBGene00011684", "H2KYQ5", "WBGene00006863", "O45819", "WBGene00012020", "G5ECZ5", "WBGene00011684", "H2KYQ5", "WBGene00006863", "O45819", "WBGene00012020", "Q9U2D9", "WBGene00001793", "species_114632" ] }, "reaction_10547383": { "compartment": "compartment_70101", "id": "reaction_10547383", "reactome": "R-CEL-3322057", "name": "GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10547376" ], "products": [ "species_10547381" ], "modifiers": [ [ "species_10547328", "catalyst" ] ], "additional_components": [ "species_114632", "H2KYQ5", "WBGene00006863", "Q9U2D9", "WBGene00001793", "species_114632", "H2KYQ5", "WBGene00006863", "Q9U2D9", "WBGene00001793", "WBGene00011409" ] }, "reaction_10572378": { "compartment": "compartment_70101", "id": "reaction_10572378", "reactome": "R-CEL-9638125", "name": "PGM1:Mg2+ isomerises G1P to G6P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29548" ], "products": [ "species_30537" ], "modifiers": [ [ "species_10572375", "catalyst" ] ], "additional_components": [ "Q21742", "WBGene00019890", "species_114632" ] }, "reaction_10547356": { "compartment": "compartment_70101", "id": "reaction_10547356", "reactome": "R-CEL-3322014", "name": "Autoglucosylation of GYG2 complexed with GYS2-a", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10547353", "species_29410" ], "products": [ "species_10547346", "species_110096" ], "modifiers": [ [ "species_10547353", "catalyst" ] ], "additional_components": [ "Q9U2D9", "WBGene00001793", "species_114632", "G5ECZ5", "WBGene00011684", "H2KYQ5", "WBGene00006863", "O45819", "WBGene00012020", "G5ECZ5", "WBGene00011684", "H2KYQ5", "WBGene00006863", "O45819", "WBGene00012020", "Q9U2D9", "WBGene00001793", "species_114632", "Q9U2D9", "WBGene00001793", "species_114632", "G5ECZ5", "WBGene00011684", "H2KYQ5", "WBGene00006863", "O45819", "WBGene00012020" ] }, "reaction_10569064": { "compartment": "compartment_70101", "id": "reaction_10569064", "reactome": "R-CEL-8951850", "name": "TSPO:BZRAP1 transports CHOL from outer mitochondrial membrane to inner mitochondrial membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8951853" ], "products": [ "species_193156" ], "modifiers": [ [ "species_10569061", "catalyst" ] ], "additional_components": [ "C7FZU5", "WBGene00077771", "Q9N415", "WBGene00006513" ] }, "reaction_10513657": { "compartment": "compartment_70101", "id": "reaction_10513657", "reactome": "R-CEL-196060", "name": "Reduction of isocaproaldehyde to 4-methylpentan-1-ol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_196095", "species_70106", "species_29364" ], "products": [ "species_29366", "species_196066" ], "modifiers": [ [ "species_10513654", "catalyst" ] ], "additional_components": [ "WBGene00016985" ] }, "reaction_10556977": { "compartment": "compartment_70101", "id": "reaction_10556977", "reactome": "R-CEL-5693390", "name": "HSD17B11 dehydrogenates EST17b to E1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193132", "species_29366" ], "products": [ "species_70106", "species_193066", "species_29364" ], "modifiers": [ [ "species_10556974", "catalyst" ] ], "additional_components": [ "A5JYX5", "WBGene00000967", "O18030", "WBGene00000968", "Q19843", "WBGene00000992", "Q22392", "WBGene00000982" ] }, "reaction_10557699": { "compartment": "compartment_5460", "id": "reaction_10557699", "reactome": "R-CEL-5696822", "name": "AKR1B15 reduces EST17b to E1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113563", "species_5696835" ], "products": [ "species_113529", "species_5696848", "species_113600" ], "modifiers": [ [ "species_10557696", "catalyst" ] ], "additional_components": [ "P91020", "WBGene00016985", "Q18903", "WBGene00016985", "Q23320", "WBGene00016985" ] }, "reaction_10513367": { "compartment": "compartment_70101", "id": "reaction_10513367", "reactome": "R-CEL-193143", "name": "CYP19A1 hydroxylates TEST to EST17b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29368", "species_29364", "species_193057" ], "products": [ "species_193132", "species_29356", "species_29366", "species_29460" ], "modifiers": [ [ "species_10513352", "catalyst" ] ], "additional_components": [ "Q09660", "WBGene00000375", "Q9N525", "WBGene00021412", "Q9N574", "WBGene00021200", "Q9XVA6", "WBGene00008499", "G5EC97", "WBGene00011830", "G5EGT6", "WBGene00010354", "O17851", "WBGene00009226", "O45219", "WBGene00007140" ] }, "reaction_10565899": { "compartment": "compartment_70101", "id": "reaction_10565899", "reactome": "R-CEL-8862137", "name": "HSD17B2 oxidises estradiol (E2) to estrone (E1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_176619", "species_29366" ], "products": [ "species_70106", "species_193066", "species_29364" ], "modifiers": [ [ "species_10565896", "catalyst" ] ], "additional_components": [ "O01758", "WBGene00000966", "O16881", "WBGene00000979", "Q20012", "WBGene00000983", "Q20840", "WBGene00018885" ] }, "reaction_10533200": { "compartment": "compartment_984", "id": "reaction_10533200", "reactome": "R-CEL-1449687", "name": "Corticosteroids bind to CBG in blood", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1449707", "species_10533196" ], "products": [ "species_10533198" ], "modifiers": [], "additional_components": [ "CHEBI:27584", "CHEBI:17026", "species_193977", "CHEBI:16973", "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "A9Z1L1", "WBGene00005648", "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "A9Z1L1", "WBGene00005648", "CHEBI:27584", "CHEBI:17026", "species_193977", "CHEBI:16973" ] }, "reaction_10513471": { "compartment": "compartment_17957", "id": "reaction_10513471", "reactome": "R-CEL-194023", "name": "HSD11B2,HSD11B1 dimer oxidise CORT to COR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193977", "species_29366" ], "products": [ "species_70106", "species_29364", "species_194035" ], "modifiers": [ [ "species_10513468", "catalyst" ] ], "additional_components": [ "O16881", "WBGene00000979", "Q20012", "WBGene00000983", "Q20840", "WBGene00018885", "O01758", "WBGene00000966" ] }, "reaction_10573281": { "compartment": "compartment_70101", "id": "reaction_10573281", "reactome": "R-CEL-9705713", "name": "SRD5A2 dehydrogenates TEST to DHTEST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_193057" ], "products": [ "species_469662", "species_29366" ], "modifiers": [ [ "species_10573278", "catalyst" ] ], "additional_components": [ "Q19605", "WBGene00014241", "Q20344", "WBGene00009635", "Q23431", "WBGene00014241" ] }, "reaction_10513365": { "compartment": "compartment_70101", "id": "reaction_10513365", "reactome": "R-CEL-193064", "name": "HSD17B3-like proteins reducde ANDST to TEST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_193079", "species_29364" ], "products": [ "species_29366", "species_193057" ], "modifiers": [ [ "species_10513360", "catalyst" ] ], "additional_components": [ "WBGene00000969" ] }, "reaction_10573284": { "compartment": "compartment_70101", "id": "reaction_10573284", "reactome": "R-CEL-9705714", "name": "SRD5A3 dehydrogenates TEST to DHTEST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_193057" ], "products": [ "species_469662", "species_29366" ], "modifiers": [ [ "species_10549201", "catalyst" ] ], "additional_components": [ "WBGene00007102" ] }, "reaction_10526217": { "compartment": "compartment_70101", "id": "reaction_10526217", "reactome": "R-CEL-469659", "name": "SRD5A1 dehydrogenates TEST to DHTEST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_193057" ], "products": [ "species_469662", "species_29366" ], "modifiers": [ [ "species_10526214", "catalyst" ] ], "additional_components": [ "WBGene00009635" ] }, "reaction_10567315": { "compartment": "compartment_70101", "id": "reaction_10567315", "reactome": "R-CEL-8875451", "name": "MET phosphorylates CBL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10567312" ], "products": [ "species_29370", "species_10567233" ], "modifiers": [ [ "species_10567312", "catalyst" ] ], "additional_components": [ "Q9XVQ7", "WBGene00008711", "P29355", "WBGene00004774", "Q19019", "WBGene00004829", "Q9XVQ7", "WBGene00008711", "P29355", "WBGene00004774", "Q19019", "WBGene00004829", "Q9XVQ7", "WBGene00008711", "P29355", "WBGene00004774", "Q19019", "WBGene00004829" ] }, "reaction_10567305": { "compartment": "compartment_876", "id": "reaction_10567305", "reactome": "R-CEL-8875374", "name": "MET binds LRIG1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10521542", "species_10567301" ], "products": [ "species_10567303" ], "modifiers": [], "additional_components": [ "WBGene00008711", "WBGene00020649", "Q965M2", "WBGene00020649", "Q9XVQ7", "WBGene00008711" ] }, "reaction_10567321": { "compartment": "compartment_70101", "id": "reaction_10567321", "reactome": "R-CEL-8875490", "name": "EPS15 and HGS bind ubiquitinated MET", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10512223", "species_10567317" ], "products": [ "species_10567319" ], "modifiers": [], "additional_components": [ "Q9BIF4", "WBGene00001224", "Q17796", "WBGene00004101", "O01498", "WBGene00004109", "Q9BIF4", "WBGene00001224", "Q17796", "WBGene00004101", "O01498", "WBGene00004109" ] }, "reaction_10567245": { "compartment": "compartment_70101", "id": "reaction_10567245", "reactome": "R-CEL-8875183", "name": "CBL monoubiquitinates activated MET", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502375", "species_10567233" ], "products": [ "species_10567242" ], "modifiers": [ [ "species_10567233", "catalyst" ] ], "additional_components": [ "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "Q9XVQ7", "WBGene00008711", "P29355", "WBGene00004774", "Q19019", "WBGene00004829", "Q9XVQ7", "WBGene00008711", "P29355", "WBGene00004774", "Q19019", "WBGene00004829", "Q9XVQ7", "WBGene00008711", "P29355", "WBGene00004774", "Q19019", "WBGene00004829" ] }, "reaction_10508741": { "compartment": "compartment_7660", "id": "reaction_10508741", "reactome": "R-CEL-110308", "name": "REV1 inserts dCMP opposite to AP sites in DNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508730", "species_30185" ], "products": [ "species_10508738" ], "modifiers": [ [ "species_10508730", "catalyst" ] ], "additional_components": [ "Q95Y97", "WBGene00019767", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "O02115", "WBGene00003955", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "Q09615", "WBGene00014066", "Q95Y97", "WBGene00019767", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "O02115", "WBGene00003955", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "Q09615", "WBGene00014066", "Q95Y97", "WBGene00019767", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "O02115", "WBGene00003955", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "Q09615", "WBGene00014066" ] }, "reaction_10508732": { "compartment": "compartment_7660", "id": "reaction_10508732", "reactome": "R-CEL-110307", "name": "REV1 binds AP-dsDNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508715", "species_10508728" ], "products": [ "species_10508730" ], "modifiers": [], "additional_components": [ "WBGene00014066", "Q95Y97", "WBGene00019767", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "O02115", "WBGene00003955", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "Q95Y97", "WBGene00019767", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "O02115", "WBGene00003955", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "Q09615", "WBGene00014066" ] }, "reaction_10567136": { "compartment": "compartment_70101", "id": "reaction_10567136", "reactome": "R-CEL-8873850", "name": "STARD5 binds DCA, LCA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_176655", "species_10567132", "species_5357505" ], "products": [ "species_10567134" ], "modifiers": [], "additional_components": [ "WBGene00010505", "species_5357505", "Q21130", "WBGene00010505", "species_176655" ] }, "reaction_10510001": { "compartment": "compartment_70101", "id": "reaction_10510001", "reactome": "R-CEL-159425", "name": "Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_76194", "species_194096" ], "products": [ "species_111294", "species_29356", "species_194073", "species_76577" ], "modifiers": [ [ "species_10509998", "catalyst" ] ], "additional_components": [ "species_193451", "CHEBI:16755", "species_192356", "species_193472", "Q18916", "WBGene00017012", "Q19878", "WBGene00009218" ] }, "reaction_10513491": { "compartment": "compartment_876", "id": "reaction_10513491", "reactome": "R-CEL-194187", "name": "SLC10A2 transports bile salts and acids and Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10513481", "species_192483", "species_74113" ], "products": [ "species_10513483", "species_83910" ], "modifiers": [ [ "species_10513488", "catalyst" ] ], "additional_components": [ "O01812", "WBGene00002258", "O01814", "WBGene00002257", "O02323", "WBGene00002259", "O02324", "WBGene00002260", "CHEBI:17687", "CHEBI:28865", "CHEBI:16755", "CHEBI:36274", "species_193451", "CHEBI:9407", "O01812", "WBGene00002258", "O01814", "WBGene00002257", "O02323", "WBGene00002259", "O02324", "WBGene00002260", "species_193451", "CHEBI:17687", "CHEBI:36274", "CHEBI:16525", "CHEBI:16755", "CHEBI:28865", "WBGene00044650" ] }, "reaction_10551492": { "compartment": "compartment_7660", "id": "reaction_10551492", "reactome": "R-CEL-5340195", "name": "NR1H4 binds DCA, CDCA, LCHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5340249", "species_10519476" ], "products": [ "species_10551490" ], "modifiers": [], "additional_components": [ "species_176655", "CHEBI:16755", "species_5357505", "WBGene00006790", "G5ECR9", "WBGene00006790", "species_176655", "CHEBI:16755", "species_5357505" ] }, "reaction_10513382": { "compartment": "compartment_876", "id": "reaction_10513382", "reactome": "R-CEL-193362", "name": "ABCB11 transports bile salts from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_193416", "species_113592" ], "products": [ "species_29372", "species_29370", "species_193479" ], "modifiers": [ [ "species_10513379", "catalyst" ] ], "additional_components": [ "CHEBI:17687", "CHEBI:36274", "CHEBI:16525", "CHEBI:28865", "CHEBI:17687", "CHEBI:28865", "CHEBI:36274", "CHEBI:9407", "P34712", "WBGene00003995", "G5EG58", "WBGene00004003" ] }, "reaction_10510026": { "compartment": "compartment_70101", "id": "reaction_10510026", "reactome": "R-CEL-159431", "name": "Cytosolic chenodeoxycholoyl-CoA or choloyl-CoA are conjugated with glycine or taurine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_194073", "species_194069" ], "products": [ "species_193416", "species_76194" ], "modifiers": [ [ "species_10510023", "catalyst" ] ], "additional_components": [ "species_192356", "species_193472", "species_159549", "CHEBI:15891", "CHEBI:17687", "CHEBI:36274", "CHEBI:16525", "CHEBI:28865", "O45003", "WBGene00020989", "Q9GYN3", "WBGene00020989", "B3WFZ3", "WBGene00020989", "O01862", "WBGene00020989" ] }, "reaction_10513424": { "compartment": "compartment_17951", "id": "reaction_10513424", "reactome": "R-CEL-193736", "name": "Isomerization of 3,7,24THCA-CoA to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193732" ], "products": [ "species_193732" ], "modifiers": [ [ "species_10513241", "catalyst" ] ], "additional_components": [ "WBGene00016034" ] }, "reaction_10513426": { "compartment": "compartment_70101", "id": "reaction_10513426", "reactome": "R-CEL-193743", "name": "3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_76194", "species_193778" ], "products": [ "species_111294", "species_29356", "species_193739", "species_76577" ], "modifiers": [ [ "species_10513398", "catalyst" ] ], "additional_components": [ "Q18916", "WBGene00017012", "Q19878", "WBGene00009218" ] }, "reaction_10513428": { "compartment": "compartment_70101", "id": "reaction_10513428", "reactome": "R-CEL-193746", "name": "4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193724", "species_70106", "species_29364" ], "products": [ "species_29366", "species_193760" ], "modifiers": [ [ "species_10513222", "catalyst" ] ], "additional_components": [ "Q23320", "WBGene00016985", "P91020", "WBGene00016985", "Q18903", "WBGene00016985" ] }, "reaction_10513430": { "compartment": "compartment_70101", "id": "reaction_10513430", "reactome": "R-CEL-193755", "name": "4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_193745" ], "products": [ "species_193707", "species_29366" ], "modifiers": [ [ "species_10513222", "catalyst" ] ], "additional_components": [ "Q23320", "WBGene00016985", "P91020", "WBGene00016985", "Q18903", "WBGene00016985" ] }, "reaction_10513432": { "compartment": "compartment_70101", "id": "reaction_10513432", "reactome": "R-CEL-193758", "name": "5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_193760" ], "products": [ "species_29366", "species_213285" ], "modifiers": [ [ "species_10513233", "catalyst" ] ], "additional_components": [ "P91020", "WBGene00016985", "Q18903", "WBGene00016985", "Q23320", "WBGene00016985" ] }, "reaction_10513434": { "compartment": "compartment_17951", "id": "reaction_10513434", "reactome": "R-CEL-193763", "name": "Isomerization of 25(R) TetraHCA-CoA to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193793" ], "products": [ "species_193422" ], "modifiers": [ [ "species_10513241", "catalyst" ] ], "additional_components": [ "WBGene00016034" ] }, "reaction_10513436": { "compartment": "compartment_70101", "id": "reaction_10513436", "reactome": "R-CEL-193766", "name": "TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_76194", "species_193762" ], "products": [ "species_111294", "species_193741", "species_29356", "species_76577" ], "modifiers": [ [ "species_10509998", "catalyst" ] ], "additional_components": [ "Q18916", "WBGene00017012", "Q19878", "WBGene00009218" ] }, "reaction_10513420": { "compartment": "compartment_70101", "id": "reaction_10513420", "reactome": "R-CEL-193711", "name": "3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_76194", "species_193778" ], "products": [ "species_111294", "species_29356", "species_193739", "species_76577" ], "modifiers": [ [ "species_10509998", "catalyst" ] ], "additional_components": [ "Q18916", "WBGene00017012", "Q19878", "WBGene00009218" ] }, "reaction_10513438": { "compartment": "compartment_70101", "id": "reaction_10513438", "reactome": "R-CEL-193781", "name": "5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_193707", "species_29364" ], "products": [ "species_29366", "species_193728" ], "modifiers": [ [ "species_10513233", "catalyst" ] ], "additional_components": [ "P91020", "WBGene00016985", "Q18903", "WBGene00016985", "Q23320", "WBGene00016985" ] }, "reaction_10513422": { "compartment": "compartment_70101", "id": "reaction_10513422", "reactome": "R-CEL-193727", "name": "TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_76194", "species_193762" ], "products": [ "species_111294", "species_193741", "species_29356", "species_76577" ], "modifiers": [ [ "species_10513398", "catalyst" ] ], "additional_components": [ "Q18916", "WBGene00017012", "Q19878", "WBGene00009218" ] }, "reaction_10513440": { "compartment": "compartment_70101", "id": "reaction_10513440", "reactome": "R-CEL-193800", "name": "5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_193829", "species_29364" ], "products": [ "species_29366", "species_193843" ], "modifiers": [ [ "species_10513233", "catalyst" ] ], "additional_components": [ "P91020", "WBGene00016985", "Q18903", "WBGene00016985", "Q23320", "WBGene00016985" ] }, "reaction_10513442": { "compartment": "compartment_70101", "id": "reaction_10513442", "reactome": "R-CEL-193821", "name": "4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_9617026" ], "products": [ "species_193829", "species_29366" ], "modifiers": [ [ "species_10513222", "catalyst" ] ], "additional_components": [ "Q23320", "WBGene00016985", "P91020", "WBGene00016985", "Q18903", "WBGene00016985" ] }, "reaction_10513444": { "compartment": "compartment_70101", "id": "reaction_10513444", "reactome": "R-CEL-193824", "name": "4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_193835", "species_29364" ], "products": [ "species_29366", "species_193830" ], "modifiers": [ [ "species_10513222", "catalyst" ] ], "additional_components": [ "Q23320", "WBGene00016985", "P91020", "WBGene00016985", "Q18903", "WBGene00016985" ] }, "reaction_10513446": { "compartment": "compartment_70101", "id": "reaction_10513446", "reactome": "R-CEL-193841", "name": "5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_193830" ], "products": [ "species_29366", "species_193842" ], "modifiers": [ [ "species_10513233", "catalyst" ] ], "additional_components": [ "P91020", "WBGene00016985", "Q18903", "WBGene00016985", "Q23320", "WBGene00016985" ] }, "reaction_10513205": { "compartment": "compartment_70101", "id": "reaction_10513205", "reactome": "R-CEL-191983", "name": "Cholesterol is hydroxylated to 25-hydroxycholesterol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_176478", "species_70106", "species_29368", "species_29364" ], "products": [ "species_29356", "species_192148", "species_29366" ], "modifiers": [ [ "species_10513202", "catalyst" ] ], "additional_components": [ "Q20027", "WBGene00018036", "species_113531" ] }, "reaction_10566516": { "compartment": "compartment_70101", "id": "reaction_10566516", "reactome": "R-CEL-8868402", "name": "OSBP exchanges 25OH-CHOL with PI4P from ER membrane to Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8868399", "species_1806217" ], "products": [ "species_8868393", "species_1806234" ], "modifiers": [ [ "species_10566513", "catalyst" ] ], "additional_components": [ "WBGene00012930" ] }, "reaction_10566397": { "compartment": "compartment_70101", "id": "reaction_10566397", "reactome": "R-CEL-8867667", "name": "OSBPs transport 25OH-CHOL from ER membrane to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8868399" ], "products": [ "species_8868400" ], "modifiers": [ [ "species_10566394", "catalyst" ] ], "additional_components": [ "Q93485", "WBGene00008832", "O01686", "WBGene00016331" ] }, "reaction_10513248": { "compartment": "compartment_70101", "id": "reaction_10513248", "reactome": "R-CEL-192137", "name": "THCA is conjugated with Coenzyme A (SLC27A5 BACS)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_192013", "species_113592", "species_76194" ], "products": [ "species_111294", "species_192096", "species_76577" ], "modifiers": [ [ "species_10509998", "catalyst" ] ], "additional_components": [ "Q18916", "WBGene00017012", "Q19878", "WBGene00009218" ] }, "reaction_10513250": { "compartment": "compartment_70101", "id": "reaction_10513250", "reactome": "R-CEL-192160", "name": "5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191980", "species_70106", "species_29364" ], "products": [ "species_192030", "species_29366" ], "modifiers": [ [ "species_10513233", "catalyst" ] ], "additional_components": [ "P91020", "WBGene00016985", "Q18903", "WBGene00016985", "Q23320", "WBGene00016985" ] }, "reaction_10513410": { "compartment": "compartment_17951", "id": "reaction_10513410", "reactome": "R-CEL-193455", "name": "(24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193422", "species_192307" ], "products": [ "species_193465", "species_192305", "species_192339" ], "modifiers": [ [ "species_10513270", "catalyst" ] ], "additional_components": [ "Q19058", "WBGene00017123" ] }, "reaction_10513412": { "compartment": "compartment_17951", "id": "reaction_10513412", "reactome": "R-CEL-193491", "name": "Chenodeoxycholoyl CoA reacts with glycine or taurine to form glycochenodeoxycholate or taurochenodeoxycholate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193463", "species_193472" ], "products": [ "species_193453", "species_193514" ], "modifiers": [ [ "species_10513260", "catalyst" ] ], "additional_components": [ "species_159549", "CHEBI:15891", "CHEBI:36274", "CHEBI:16525", "B3WFZ3", "WBGene00020989", "O01862", "WBGene00020989", "O45003", "WBGene00020989", "Q9GYN3", "WBGene00020989" ] }, "reaction_10513414": { "compartment": "compartment_17951", "id": "reaction_10513414", "reactome": "R-CEL-193508", "name": "(24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193732", "species_192307" ], "products": [ "species_193465", "species_193403", "species_192305" ], "modifiers": [ [ "species_10513270", "catalyst" ] ], "additional_components": [ "Q19058", "WBGene00017123" ] }, "reaction_10513384": { "compartment": "compartment_17951", "id": "reaction_10513384", "reactome": "R-CEL-193369", "name": "25(S) DHCA-CoA is dehydrogenated to 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113535", "species_193442" ], "products": [ "species_113575", "species_193459" ], "modifiers": [ [ "species_10513307", "catalyst" ] ], "additional_components": [ "species_113596", "P34355", "WBGene00008167", "O62138", "WBGene00008566", "Q93839", "WBGene00010336", "O62139", "WBGene00008567", "O62140", "WBGene00008564", "O62137", "WBGene00008565" ] }, "reaction_10513416": { "compartment": "compartment_17951", "id": "reaction_10513416", "reactome": "R-CEL-193535", "name": "25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA is hydrated to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_141343", "species_193459" ], "products": [ "species_193732" ], "modifiers": [ [ "species_10513270", "catalyst" ] ], "additional_components": [ "Q19058", "WBGene00017123" ] }, "reaction_10513225": { "compartment": "compartment_70101", "id": "reaction_10513225", "reactome": "R-CEL-192033", "name": "4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_192136", "species_29364" ], "products": [ "species_191980", "species_29366" ], "modifiers": [ [ "species_10513222", "catalyst" ] ], "additional_components": [ "Q23320", "WBGene00016985", "P91020", "WBGene00016985", "Q18903", "WBGene00016985" ] }, "reaction_10513263": { "compartment": "compartment_17951", "id": "reaction_10513263", "reactome": "R-CEL-192312", "name": "Choloyl CoA reacts with glycine or taurine to form glycocholate or taurocholate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_192356", "species_193463" ], "products": [ "species_193404", "species_193514" ], "modifiers": [ [ "species_10513260", "catalyst" ] ], "additional_components": [ "species_159549", "CHEBI:15891", "CHEBI:17687", "CHEBI:28865", "B3WFZ3", "WBGene00020989", "O01862", "WBGene00020989", "O45003", "WBGene00020989", "Q9GYN3", "WBGene00020989" ] }, "reaction_10513392": { "compartment": "compartment_17951", "id": "reaction_10513392", "reactome": "R-CEL-193385", "name": "Hydrolysis of choloyl-CoA to cholate and CoASH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_141343", "species_192356" ], "products": [ "species_193451", "species_193514" ], "modifiers": [ [ "species_10513389", "catalyst" ] ], "additional_components": [ "WBGene00015887" ] }, "reaction_10513236": { "compartment": "compartment_70101", "id": "reaction_10513236", "reactome": "R-CEL-192036", "name": "5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_192064" ], "products": [ "species_29366", "species_192087" ], "modifiers": [ [ "species_10513233", "catalyst" ] ], "additional_components": [ "P91020", "WBGene00016985", "Q18903", "WBGene00016985", "Q23320", "WBGene00016985" ] }, "reaction_10513401": { "compartment": "compartment_70101", "id": "reaction_10513401", "reactome": "R-CEL-193401", "name": "THCA is conjugated with Coenzyme A (SLC27A2 VLCS)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_192013", "species_113592", "species_76194" ], "products": [ "species_111294", "species_192096", "species_76577" ], "modifiers": [ [ "species_10513398", "catalyst" ] ], "additional_components": [ "Q18916", "WBGene00017012", "Q19878", "WBGene00009218" ] }, "reaction_10513273": { "compartment": "compartment_17951", "id": "reaction_10513273", "reactome": "R-CEL-192331", "name": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) is hydrated to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_141343", "species_192342" ], "products": [ "species_193422" ], "modifiers": [ [ "species_10513270", "catalyst" ] ], "additional_components": [ "Q19058", "WBGene00017123" ] }, "reaction_10513403": { "compartment": "compartment_70101", "id": "reaction_10513403", "reactome": "R-CEL-193407", "name": "DHCA is conjugated with Coenzyme A (SLC27A5 BACS)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_193505", "species_76194" ], "products": [ "species_111294", "species_193457", "species_76577" ], "modifiers": [ [ "species_10509998", "catalyst" ] ], "additional_components": [ "Q18916", "WBGene00017012", "Q19878", "WBGene00009218" ] }, "reaction_10513244": { "compartment": "compartment_17951", "id": "reaction_10513244", "reactome": "R-CEL-192056", "name": "Isomerization of 25(R) THCA-CoA to 25(S) THCA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_192308" ], "products": [ "species_192316" ], "modifiers": [ [ "species_10513241", "catalyst" ] ], "additional_components": [ "WBGene00016034" ] }, "reaction_10513405": { "compartment": "compartment_70101", "id": "reaction_10513405", "reactome": "R-CEL-193424", "name": "DHCA is conjugated with Coenzyme A (SLC27A2 VLCS)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_76194", "species_193505" ], "products": [ "species_111294", "species_193457", "species_76577" ], "modifiers": [ [ "species_10513398", "catalyst" ] ], "additional_components": [ "Q18916", "WBGene00017012", "Q19878", "WBGene00009218" ] }, "reaction_10513246": { "compartment": "compartment_70101", "id": "reaction_10513246", "reactome": "R-CEL-192067", "name": "4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_192195" ], "products": [ "species_29366", "species_192064" ], "modifiers": [ [ "species_10513222", "catalyst" ] ], "additional_components": [ "Q23320", "WBGene00016985", "P91020", "WBGene00016985", "Q18903", "WBGene00016985" ] }, "reaction_10513310": { "compartment": "compartment_17951", "id": "reaction_10513310", "reactome": "R-CEL-192335", "name": "25(S) THCA-CoA is dehydrogenated to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113535", "species_192316" ], "products": [ "species_113575", "species_192342" ], "modifiers": [ [ "species_10513307", "catalyst" ] ], "additional_components": [ "species_113596", "P34355", "WBGene00008167", "O62138", "WBGene00008566", "Q93839", "WBGene00010336", "O62139", "WBGene00008567", "O62140", "WBGene00008564", "O62137", "WBGene00008565" ] }, "reaction_10513407": { "compartment": "compartment_17951", "id": "reaction_10513407", "reactome": "R-CEL-193452", "name": "Isomerization of 25(R) DHCA-CoA to 25(S) DHCA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193429" ], "products": [ "species_193442" ], "modifiers": [ [ "species_10513241", "catalyst" ] ], "additional_components": [ "WBGene00016034" ] }, "reaction_10516904": { "compartment": "compartment_13231", "id": "reaction_10516904", "reactome": "R-CEL-211219", "name": "Translocation of caspase-3 to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509422" ], "products": [ "species_10516902" ], "modifiers": [], "additional_components": [ "P42573", "WBGene00000417", "P42573", "WBGene00000417" ] }, "reaction_10517886": { "compartment": "compartment_7660", "id": "reaction_10517886", "reactome": "R-CEL-266204", "name": "Association of HMGB1/HMGB2 with chromatin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10517882", "species_29428" ], "products": [ "species_10517884" ], "modifiers": [], "additional_components": [ "Q09390", "WBGene00001972", "G5EFV4", "WBGene00001971", "Q09390", "WBGene00001972", "G5EFV4", "WBGene00001971" ] }, "reaction_10551440": { "compartment": "compartment_7660", "id": "reaction_10551440", "reactome": "R-CEL-5334854", "name": "RAR:RXR binds SUMO-CRABP2:atRA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10551436", "species_10551432" ], "products": [ "species_10551438" ], "modifiers": [], "additional_components": [ "species_5334816", "O01812", "WBGene00002258", "Q9U2R6", "WBGene00003681", "Q20765", "WBGene00003606", "P41830", "WBGene00004786", "Q9XUK7", "WBGene00003675", "Q10902", "WBGene00003601", "Q9U2R6", "WBGene00003681", "Q20765", "WBGene00003606", "P41830", "WBGene00004786", "Q9XUK7", "WBGene00003675", "Q10902", "WBGene00003601", "species_5334816", "O01812", "WBGene00002258" ] }, "reaction_10553123": { "compartment": "compartment_70101", "id": "reaction_10553123", "reactome": "R-CEL-5622129", "name": "FABP5 binds atRA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10551364", "species_5334816" ], "products": [ "species_10553121" ], "modifiers": [], "additional_components": [ "WBGene00021486", "species_5334816", "Q965W1", "WBGene00021486" ] }, "reaction_10552339": { "compartment": "compartment_7660", "id": "reaction_10552339", "reactome": "R-CEL-5422942", "name": "RXRA:PPARD binds FABP5:atRA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10552335", "species_10514501" ], "products": [ "species_10552337" ], "modifiers": [], "additional_components": [ "species_5334816", "Q965W1", "WBGene00021486", "Q9XUK7", "WBGene00003675", "P41830", "WBGene00004786", "Q10902", "WBGene00003601", "Q20765", "WBGene00003606", "Q9U2R6", "WBGene00003681", "Q9XUK7", "WBGene00003675", "P41830", "WBGene00004786", "Q10902", "WBGene00003601", "Q20765", "WBGene00003606", "Q9U2R6", "WBGene00003681", "species_5334816", "Q965W1", "WBGene00021486" ] }, "reaction_10552705": { "compartment": "compartment_70101", "id": "reaction_10552705", "reactome": "R-CEL-5615668", "name": "AKR1C3 reduces atRAL to atROL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_975622", "species_29364" ], "products": [ "species_29366", "species_975599" ], "modifiers": [ [ "species_10513233", "catalyst" ] ], "additional_components": [ "P91020", "WBGene00016985", "Q18903", "WBGene00016985", "Q23320", "WBGene00016985" ] }, "reaction_10551747": { "compartment": "compartment_70101", "id": "reaction_10551747", "reactome": "R-CEL-5362518", "name": "RDH10,16,DHRS9,RDHE2 oxidise atROL to atRAL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_975599", "species_29360" ], "products": [ "species_70106", "species_975622", "species_73473" ], "modifiers": [ [ "species_10551744", "catalyst" ] ], "additional_components": [ "A5JYX5", "WBGene00000967", "O18030", "WBGene00000968", "Q19843", "WBGene00000992", "Q22392", "WBGene00000982", "O16881", "WBGene00000979", "O01758", "WBGene00000966", "Q20012", "WBGene00000983", "Q20840", "WBGene00018885" ] }, "reaction_10553251": { "compartment": "compartment_70616", "id": "reaction_10553251", "reactome": "R-CEL-5623643", "name": "RDH13 reduces atRAL to atROL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5623644", "species_5623648", "species_163953" ], "products": [ "species_5623650", "species_5623649" ], "modifiers": [ [ "species_10553248", "catalyst" ] ], "additional_components": [ "WBGene00000985" ] }, "reaction_10551781": { "compartment": "compartment_70101", "id": "reaction_10551781", "reactome": "R-CEL-5362721", "name": "RDH5,RDH11 oxidise 11cROL to 11cRAL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30927", "species_29360" ], "products": [ "species_70106", "species_32737", "species_73473" ], "modifiers": [ [ "species_10551778", "catalyst" ] ], "additional_components": [ "Q20840", "WBGene00018885", "O01758", "WBGene00000966", "O16881", "WBGene00000979", "Q20012", "WBGene00000983" ] }, "reaction_10553125": { "compartment": "compartment_70101", "id": "reaction_10553125", "reactome": "R-CEL-5622134", "name": "CRABP1 binds atRA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5334816", "species_10551761" ], "products": [ "species_10551763" ], "modifiers": [], "additional_components": [ "O01812", "WBGene00002258", "O01814", "WBGene00002257", "O02323", "WBGene00002259", "O02324", "WBGene00002260", "O01812", "WBGene00002258", "O01814", "WBGene00002257", "O02323", "WBGene00002259", "O02324", "WBGene00002260", "species_5334816" ] }, "reaction_10551862": { "compartment": "compartment_70101", "id": "reaction_10551862", "reactome": "R-CEL-5419165", "name": "RDH11,14,DHRS3,DRHS4 reduce atRAL to atROL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_975622", "species_29364" ], "products": [ "species_29366", "species_975599" ], "modifiers": [ [ "species_10551859", "catalyst" ] ], "additional_components": [ "P91013", "WBGene00000965", "Q1XFZ3", "WBGene00000980", "A5JYX5", "WBGene00000967", "O18030", "WBGene00000968", "Q19843", "WBGene00000992", "Q22392", "WBGene00000982", "G5EGA6", "WBGene00010063" ] }, "reaction_10551768": { "compartment": "compartment_70101", "id": "reaction_10551768", "reactome": "R-CEL-5362564", "name": "ADH1A,1C,4 oxidise atROL to atRAL in vitro", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_975599", "species_29360" ], "products": [ "species_70106", "species_975622", "species_73473" ], "modifiers": [ [ "species_10551765", "catalyst" ] ], "additional_components": [ "species_216785", "Q17335", "WBGene00019240" ] }, "reaction_10557581": { "compartment": "compartment_70101", "id": "reaction_10557581", "reactome": "R-CEL-5696101", "name": "ALDH8A1 oxidises 9cRAL to 9cRA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_5362565", "species_29360" ], "products": [ "species_70106", "species_5362520", "species_73473" ], "modifiers": [ [ "species_10557578", "catalyst" ] ], "additional_components": [ "WBGene00000116" ] }, "reaction_10554022": { "compartment": "compartment_70101", "id": "reaction_10554022", "reactome": "R-CEL-5633256", "name": "FABP5:atRA translocates from cytosol to nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10553121" ], "products": [ "species_10552335" ], "modifiers": [], "additional_components": [ "species_5334816", "Q965W1", "WBGene00021486", "species_5334816", "Q965W1", "WBGene00021486" ] }, "reaction_10554024": { "compartment": "compartment_7660", "id": "reaction_10554024", "reactome": "R-CEL-5634100", "name": "FABP5 dissociates from RXRA:PPARD:atRA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10552337" ], "products": [ "species_10552333", "species_10514503" ], "modifiers": [], "additional_components": [ "Q9XUK7", "WBGene00003675", "P41830", "WBGene00004786", "Q10902", "WBGene00003601", "Q20765", "WBGene00003606", "Q9U2R6", "WBGene00003681", "species_5334816", "Q965W1", "WBGene00021486", "WBGene00021486", "Q9XUK7", "WBGene00003675", "P41830", "WBGene00004786", "Q10902", "WBGene00003601", "Q20765", "WBGene00003606", "Q9U2R6", "WBGene00003681", "species_5334816" ] }, "reaction_10514505": { "compartment": "compartment_70101", "id": "reaction_10514505", "reactome": "R-CEL-200406", "name": "CPT1A,B transfers PALM to CAR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_549207", "species_200993" ], "products": [ "species_201034", "species_76194" ], "modifiers": [ [ "species_10514471", "catalyst" ], [ "species_10514503", "catalyst" ], [ "species_29508", "inhibitor" ] ], "additional_components": [ "Q9N3N3", "WBGene00021703", "O16992", "WBGene00021002", "Q9U2F2", "WBGene00012907", "O44619", "WBGene00019644", "Q23066", "WBGene00020911", "G5EG54", "WBGene00008629", "Q9XUK7", "WBGene00003675", "P41830", "WBGene00004786", "Q10902", "WBGene00003601", "Q20765", "WBGene00003606", "Q9U2R6", "WBGene00003681", "species_5334816" ] }, "reaction_10554028": { "compartment": "compartment_7660", "id": "reaction_10554028", "reactome": "R-CEL-5634103", "name": "SUMO-CRABP2 dissociates from atRA:RAR:RXR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10551438" ], "products": [ "species_10551434", "species_10554026" ], "modifiers": [], "additional_components": [ "Q9U2R6", "WBGene00003681", "Q20765", "WBGene00003606", "P41830", "WBGene00004786", "Q9XUK7", "WBGene00003675", "Q10902", "WBGene00003601", "species_5334816", "O01812", "WBGene00002258", "WBGene00002258", "species_5334816", "Q9U2R6", "WBGene00003681", "Q20765", "WBGene00003606", "P41830", "WBGene00004786", "Q9XUK7", "WBGene00003675", "Q10902", "WBGene00003601" ] }, "reaction_10551391": { "compartment": "compartment_70101", "id": "reaction_10551391", "reactome": "R-CEL-5334827", "name": "SUMO-CRABP2 binds atRA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10551387", "species_5334816" ], "products": [ "species_10551389" ], "modifiers": [], "additional_components": [ "WBGene00002258", "species_5334816", "O01812", "WBGene00002258" ] }, "reaction_10554030": { "compartment": "compartment_70101", "id": "reaction_10554030", "reactome": "R-CEL-5634104", "name": "SUMO-CRABP2:atRA translocates from cytosol to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10551389" ], "products": [ "species_10551436" ], "modifiers": [], "additional_components": [ "species_5334816", "O01812", "WBGene00002258", "species_5334816", "O01812", "WBGene00002258" ] }, "reaction_10570912": { "compartment": "compartment_7660", "id": "reaction_10570912", "reactome": "R-CEL-9012319", "name": "p-TEFb phosphorylates serine 2 in RNA polymerase II CTD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10570907" ], "products": [ "species_113582", "species_10570909" ], "modifiers": [ [ "species_10570907", "catalyst" ] ], "additional_components": [ "Q9TVL3", "WBGene00000410", "P34424", "WBGene00000508", "P34425", "WBGene00000507", "species_1254400", "P16356", "WBGene00000123", "Q19826", "WBGene00017830", "Q9XVH6", "WBGene00012187", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q9U3I0", "WBGene00009078", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q10578", "WBGene00016140", "Q17684", "WBGene00007355", "O02092", "WBGene00018391", "Q9GR61", "WBGene00021347", "Q9N3C9", "WBGene00021845", "Q93338", "WBGene00007971", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q9TVL3", "WBGene00000410", "P34424", "WBGene00000508", "P34425", "WBGene00000507", "species_1254400", "Q9TVL3", "WBGene00000410", "P34424", "WBGene00000508", "P34425", "WBGene00000507", "species_1254400", "P16356", "WBGene00000123", "Q19826", "WBGene00017830", "Q9XVH6", "WBGene00012187", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q9U3I0", "WBGene00009078", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q10578", "WBGene00016140", "Q17684", "WBGene00007355", "O02092", "WBGene00018391", "Q9GR61", "WBGene00021347", "Q9N3C9", "WBGene00021845", "Q93338", "WBGene00007971" ] }, "reaction_10570805": { "compartment": "compartment_7660", "id": "reaction_10570805", "reactome": "R-CEL-9009533", "name": "TBP and TFIIA bind TATA box on ESR1:estrogen bound TFF1 gene promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10506254", "species_10506433", "species_10570801" ], "products": [ "species_10570803" ], "modifiers": [], "additional_components": [ "WBGene00006542", "O44625", "WBGene00004136", "Q9NEX2", "WBGene00013736", "Q9XUW5", "WBGene00010260", "CHEBI:142773", "species_5696848", "species_176619", "CHEBI:27974", "G5EGN3", "WBGene00001253", "P28515", "WBGene00001249", "Q9XUW7", "WBGene00001311", "G5EF25", "WBGene00003181", "G5EF71", "WBGene00003180", "U4PMB4", "WBGene00001186", "Q21187", "WBGene00001441", "Q17381", "WBGene00004013", "Q9XUW5", "WBGene00010260", "CHEBI:142773", "species_5696848", "species_176619", "CHEBI:27974", "G5EGN3", "WBGene00001253", "P28515", "WBGene00001249", "Q9XUW7", "WBGene00001311", "G5EF25", "WBGene00003181", "G5EF71", "WBGene00003180", "U4PMB4", "WBGene00001186", "Q21187", "WBGene00001441", "Q17381", "WBGene00004013", "O44625", "WBGene00004136", "Q9NEX2", "WBGene00013736", "P32085", "WBGene00006542" ] }, "reaction_10570772": { "compartment": "compartment_7660", "id": "reaction_10570772", "reactome": "R-CEL-9009065", "name": "FOXA1 and GATA3 bind to CCND1 promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10570727", "species_10570739", "species_10570768" ], "products": [ "species_10532119", "species_10570725", "species_10570770" ], "modifiers": [], "additional_components": [ "P45972", "WBGene00011639", "G5ECH0", "WBGene00001836", "P62784", "WBGene00001875", "Q10453", "WBGene00001945", "K7ZUH9", "WBGene00001914", "Q21187", "WBGene00001441", "Q17381", "WBGene00004013", "G5EGN3", "WBGene00001253", "P28515", "WBGene00001249", "Q9XUW7", "WBGene00001311", "G5EF25", "WBGene00003181", "G5EF71", "WBGene00003180", "U4PMB4", "WBGene00001186", "WBGene00001836", "WBGene00011639", "G5EGN3", "WBGene00001253", "P28515", "WBGene00001249", "Q9XUW7", "WBGene00001311", "G5EF25", "WBGene00003181", "G5EF71", "WBGene00003180", "U4PMB4", "WBGene00001186", "Q21187", "WBGene00001441", "Q17381", "WBGene00004013", "P62784", "WBGene00001875", "Q10453", "WBGene00001945", "K7ZUH9", "WBGene00001914" ] }, "reaction_10571524": { "compartment": "compartment_7660", "id": "reaction_10571524", "reactome": "R-CEL-9023860", "name": "Histone acetyltransferases are recruited to the TFF1 gene", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10571512", "species_10571520" ], "products": [ "species_10571522" ], "modifiers": [], "additional_components": [ "Q9TYU5", "WBGene00007029", "P34545", "WBGene00000366", "Q9N3S7", "WBGene00021636", "Q9XUW5", "WBGene00010260", "CHEBI:142773", "species_5696848", "species_176619", "CHEBI:27974", "G5EGN3", "WBGene00001253", "P28515", "WBGene00001249", "Q9XUW7", "WBGene00001311", "G5EF25", "WBGene00003181", "G5EF71", "WBGene00003180", "U4PMB4", "WBGene00001186", "Q21187", "WBGene00001441", "Q17381", "WBGene00004013", "O44625", "WBGene00004136", "Q9NEX2", "WBGene00013736", "P32085", "WBGene00006542", "Q9U2X0", "WBGene00013766", "Q9XUW5", "WBGene00010260", "CHEBI:142773", "species_5696848", "species_176619", "CHEBI:27974", "G5EGN3", "WBGene00001253", "P28515", "WBGene00001249", "Q9XUW7", "WBGene00001311", "G5EF25", "WBGene00003181", "G5EF71", "WBGene00003180", "U4PMB4", "WBGene00001186", "Q21187", "WBGene00001441", "Q17381", "WBGene00004013", "O44625", "WBGene00004136", "Q9NEX2", "WBGene00013736", "P32085", "WBGene00006542", "Q9U2X0", "WBGene00013766", "Q9TYU5", "WBGene00007029", "P34545", "WBGene00000366", "Q9N3S7", "WBGene00021636" ] }, "reaction_10571526": { "compartment": "compartment_7660", "id": "reaction_10571526", "reactome": "R-CEL-9023861", "name": "PRMT1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546564", "species_10570803" ], "products": [ "species_10571518" ], "modifiers": [], "additional_components": [ "WBGene00013766", "Q9XUW5", "WBGene00010260", "CHEBI:142773", "species_5696848", "species_176619", "CHEBI:27974", "G5EGN3", "WBGene00001253", "P28515", "WBGene00001249", "Q9XUW7", "WBGene00001311", "G5EF25", "WBGene00003181", "G5EF71", "WBGene00003180", "U4PMB4", "WBGene00001186", "Q21187", "WBGene00001441", "Q17381", "WBGene00004013", "O44625", "WBGene00004136", "Q9NEX2", "WBGene00013736", "P32085", "WBGene00006542", "Q9XUW5", "WBGene00010260", "CHEBI:142773", "species_5696848", "species_176619", "CHEBI:27974", "G5EGN3", "WBGene00001253", "P28515", "WBGene00001249", "Q9XUW7", "WBGene00001311", "G5EF25", "WBGene00003181", "G5EF71", "WBGene00003180", "U4PMB4", "WBGene00001186", "Q21187", "WBGene00001441", "Q17381", "WBGene00004013", "O44625", "WBGene00004136", "Q9NEX2", "WBGene00013736", "P32085", "WBGene00006542", "Q9U2X0", "WBGene00013766" ] }, "reaction_10568500": { "compartment": "compartment_7660", "id": "reaction_10568500", "reactome": "R-CEL-8939204", "name": "ESTG binds ESR1:chaperone complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10568488", "species_1254400" ], "products": [ "species_10568490" ], "modifiers": [], "additional_components": [ "Q09637", "WBGene00000885", "Q18688", "WBGene00000915", "species_29358", "Q23280", "WBGene00022599", "species_1254400", "Q09637", "WBGene00000885", "Q18688", "WBGene00000915", "species_29358", "Q23280", "WBGene00022599" ] }, "reaction_10573334": { "compartment": "compartment_7660", "id": "reaction_10573334", "reactome": "R-CEL-9709547", "name": "ESTG binds ESR2:chaperone complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10568494", "species_1254400" ], "products": [ "species_10568496" ], "modifiers": [], "additional_components": [ "Q09637", "WBGene00000885", "Q18688", "WBGene00000915", "species_29358", "Q23280", "WBGene00022599", "species_1254400", "Q09637", "WBGene00000885", "Q18688", "WBGene00000915", "species_29358", "Q23280", "WBGene00022599" ] }, "reaction_10515169": { "compartment": "compartment_70101", "id": "reaction_10515169", "reactome": "R-CEL-202127", "name": "eNOS synthesizes NO", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29468", "species_29368", "species_29364" ], "products": [ "species_202124", "species_29366", "species_29968" ], "modifiers": [ [ "species_10515166", "catalyst" ], [ "species_5693375", "inhibitor" ] ], "additional_components": [ "Q9XTG7", "WBGene00000103", "G4S4W1", "WBGene00016980", "Q17941", "WBGene00000102", "species_74016", "Q11083", "WBGene00020378", "P04630", "WBGene00000285", "G5EF37", "WBGene00003934", "A0A2C9C3L3", "WBGene00020378", "Q18136", "WBGene00006861", "Q09665", "WBGene00006583", "O02159", "WBGene00020378", "G5EDZ8", "WBGene00000288", "Q94288", "WBGene00000287", "Q09980", "WBGene00017394", "O16305", "WBGene00000552", "G5EEG0", "WBGene00000286", "Q18688", "WBGene00000915", "species_71185", "species_216785", "species_73524", "species_113596", "species_29870" ] }, "reaction_10572255": { "compartment": "compartment_7660", "id": "reaction_10572255", "reactome": "R-CEL-9624526", "name": "AKT phosphorylates FOXO3 downstream of ESR1 and EGFR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10514276" ], "products": [ "species_113582", "species_10514290" ], "modifiers": [ [ "species_10514266", "catalyst" ] ], "additional_components": [ "WBGene00000912", "WBGene00000912", "G4S4W1", "WBGene00016980", "Q17941", "WBGene00000102", "Q9XTG7", "WBGene00000103" ] }, "reaction_10572334": { "compartment": "compartment_7660", "id": "reaction_10572334", "reactome": "R-CEL-9632873", "name": "p-S10 CDKN1B translocates to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10572330" ], "products": [ "species_10572332" ], "modifiers": [ [ "species_10514056", "catalyst" ], [ "species_10511186", "catalyst" ] ], "additional_components": [ "WBGene00000517", "WBGene00000517", "P39745", "WBGene00003401", "WBGene00002078" ] }, "reaction_10572317": { "compartment": "compartment_70101", "id": "reaction_10572317", "reactome": "R-CEL-9632412", "name": "PTK2 is recruited to methylated ESR1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10572313", "species_10572310" ], "products": [ "species_10572315" ], "modifiers": [], "additional_components": [ "WBGene00002213", "A0A486WY88", "WBGene00010631", "species_1254400", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "G5EDP9", "WBGene00000001", "Q94125", "WBGene00000090", "A0A486WY88", "WBGene00010631", "species_1254400", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "G5EDP9", "WBGene00000001", "Q94125", "WBGene00000090", "Q95YD4", "WBGene00002213" ] }, "reaction_10572284": { "compartment": "compartment_876", "id": "reaction_10572284", "reactome": "R-CEL-9625814", "name": "SPHK1 phosphorylates sphingosine in response to E2 stimulation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1606609" ], "products": [ "species_5218688" ], "modifiers": [ [ "species_10520872", "catalyst" ] ], "additional_components": [ "WBGene00007918" ] }, "reaction_10572339": { "compartment": "compartment_876", "id": "reaction_10572339", "reactome": "R-CEL-9632906", "name": "PRKCZ recruits RAS in response to estrogen stimulation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10512175", "species_10572324" ], "products": [ "species_10572337" ], "modifiers": [], "additional_components": [ "species_29420", "P22981", "WBGene00002335", "Q9UA62", "WBGene00021022", "species_179838", "Q19266", "WBGene00004034", "Q9UA62", "WBGene00021022", "species_179838", "Q19266", "WBGene00004034", "species_29420", "P22981", "WBGene00002335" ] }, "reaction_10572327": { "compartment": "compartment_876", "id": "reaction_10572327", "reactome": "R-CEL-9632858", "name": "PRKCZ autophosphorylates downstream of estrogen stimulation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10572319", "species_113592" ], "products": [ "species_29370", "species_10572324" ], "modifiers": [ [ "species_10572319", "catalyst" ] ], "additional_components": [ "Q9UA62", "WBGene00021022", "species_179838", "Q19266", "WBGene00004034", "Q9UA62", "WBGene00021022", "species_179838", "Q19266", "WBGene00004034", "Q9UA62", "WBGene00021022", "species_179838", "Q19266", "WBGene00004034" ] }, "reaction_10572343": { "compartment": "compartment_7660", "id": "reaction_10572343", "reactome": "R-CEL-9632910", "name": "ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10542080" ], "products": [ "species_10514056" ], "modifiers": [ [ "species_10572341", "catalyst" ] ], "additional_components": [ "P39745", "WBGene00003401", "P39745", "WBGene00003401", "Q9UA62", "WBGene00021022", "species_179838", "Q19266", "WBGene00004034", "species_29438", "P22981", "WBGene00002335" ] }, "reaction_10572346": { "compartment": "compartment_876", "id": "reaction_10572346", "reactome": "R-CEL-9632918", "name": "PRKCZ stimulates RAS nucleotide exchange in response to estrogen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10572337" ], "products": [ "species_10572341" ], "modifiers": [], "additional_components": [ "Q9UA62", "WBGene00021022", "species_179838", "Q19266", "WBGene00004034", "species_29420", "P22981", "WBGene00002335", "Q9UA62", "WBGene00021022", "species_179838", "Q19266", "WBGene00004034", "species_29438", "P22981", "WBGene00002335" ] }, "reaction_10571584": { "compartment": "compartment_7660", "id": "reaction_10571584", "reactome": "R-CEL-9029566", "name": "Co-repressor complex dissociates from the transcription unit of the UGT1A3 gene ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10571574" ], "products": [ "species_10571582", "species_10517933" ], "modifiers": [], "additional_components": [ "G5ECR9", "WBGene00006790", "Q9U2R6", "WBGene00003681", "CHEBI:34310", "CHEBI:67237", "CHEBI:76591", "CHEBI:41633", "P34333", "WBGene00001565", "G5ECR9", "WBGene00006790", "Q9U2R6", "WBGene00003681", "CHEBI:34310", "CHEBI:67237", "CHEBI:76591", "CHEBI:41633", "WBGene00001565" ] }, "reaction_10571576": { "compartment": "compartment_7660", "id": "reaction_10571576", "reactome": "R-CEL-9029517", "name": "Oxysterol binds to the UGT1A3 gene:NR1H2,3:RXR:NCOR complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9024383", "species_10571572" ], "products": [ "species_10571574" ], "modifiers": [], "additional_components": [ "CHEBI:34310", "CHEBI:67237", "CHEBI:76591", "CHEBI:41633", "G5ECR9", "WBGene00006790", "Q9U2R6", "WBGene00003681", "P34333", "WBGene00001565", "G5ECR9", "WBGene00006790", "Q9U2R6", "WBGene00003681", "CHEBI:34310", "CHEBI:67237", "CHEBI:76591", "CHEBI:41633", "P34333", "WBGene00001565" ] }, "reaction_10537280": { "compartment": "compartment_20699", "id": "reaction_10537280", "reactome": "R-CEL-1676133", "name": "PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806217" ], "products": [ "species_29372", "species_1524146" ], "modifiers": [ [ "species_10537269", "catalyst" ] ], "additional_components": [ "WBGene00009264" ] }, "reaction_10537217": { "compartment": "compartment_20699", "id": "reaction_10537217", "reactome": "R-CEL-1675961", "name": "PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1524146" ], "products": [ "species_29370", "species_1806159" ], "modifiers": [ [ "species_10537193", "catalyst" ] ], "additional_components": [ "Q9TXI7", "WBGene00006932", "species_266099", "Q23669", "WBGene00014151", "G5EDY0", "WBGene00009552", "species_74016", "species_114632" ] }, "reaction_10537185": { "compartment": "compartment_20699", "id": "reaction_10537185", "reactome": "R-CEL-1675928", "name": "PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A/G at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1806217" ], "products": [ "species_1806230", "species_29370" ], "modifiers": [ [ "species_10537182", "catalyst" ] ], "additional_components": [ "G5EDY0", "WBGene00009552", "species_74016", "species_114632" ] }, "reaction_10537298": { "compartment": "compartment_20699", "id": "reaction_10537298", "reactome": "R-CEL-1676152", "name": "PI4KB binds to ARF1/3:GTP at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10537169", "species_10537296" ], "products": [ "species_10537171" ], "modifiers": [], "additional_components": [ "G5EFK4", "WBGene00000183", "species_29438", "Q10943", "WBGene00000182", "WBGene00018076", "G5EFK4", "WBGene00000183", "species_29438", "Q10943", "WBGene00000182", "Q20077", "WBGene00018076" ] }, "reaction_10537141": { "compartment": "compartment_20699", "id": "reaction_10537141", "reactome": "R-CEL-1675824", "name": "PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806165", "species_29356" ], "products": [ "species_29372", "species_1806217" ], "modifiers": [ [ "species_10537138", "catalyst" ] ], "additional_components": [ "WBGene00007620" ] }, "reaction_10537174": { "compartment": "compartment_20699", "id": "reaction_10537174", "reactome": "R-CEL-1675883", "name": "PI is phosphorylated to PI4P by PI4KB at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1524146" ], "products": [ "species_29370", "species_1806217" ], "modifiers": [ [ "species_10537171", "catalyst" ] ], "additional_components": [ "G5EFK4", "WBGene00000183", "species_29438", "Q10943", "WBGene00000182", "Q20077", "WBGene00018076" ] }, "reaction_10537272": { "compartment": "compartment_20699", "id": "reaction_10537272", "reactome": "R-CEL-1676114", "name": "PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1806159" ], "products": [ "species_29372", "species_1524146" ], "modifiers": [ [ "species_10537269", "catalyst" ] ], "additional_components": [ "WBGene00009264" ] }, "reaction_10537322": { "compartment": "compartment_20699", "id": "reaction_10537322", "reactome": "R-CEL-1676185", "name": "PI is phosphorylated to PI4P by PI4KA/2A/2B at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1524146" ], "products": [ "species_29370", "species_1806217" ], "modifiers": [ [ "species_10537319", "catalyst" ] ], "additional_components": [ "O45318", "WBGene00022501", "Q23083", "WBGene00022501", "Q9XW63", "WBGene00013557" ] }, "reaction_10502079": { "compartment": "compartment_7660", "id": "reaction_10502079", "reactome": "R-CEL-68611", "name": "Orc1 associates with Orc4:Orc5:Orc3:Orc2:origin complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502075", "species_10502070" ], "products": [ "species_10502077" ], "modifiers": [], "additional_components": [ "WBGene00012650", "Q9XX16", "WBGene00012651", "Q21037", "WBGene00003882", "Q23249", "WBGene00013857", "Q9XX16", "WBGene00012651", "Q21037", "WBGene00003882", "Q23249", "WBGene00013857", "Q9XX17", "WBGene00012650" ] }, "reaction_10548052": { "compartment": "compartment_70101", "id": "reaction_10548052", "reactome": "R-CEL-3772435", "name": "WNT signaling stimulates CSNK1-dependent phosphorylation of DVL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10515075" ], "products": [ "species_29370", "species_10515002" ], "modifiers": [ [ "species_10548049", "catalyst" ] ], "additional_components": [ "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "WBGene00002203" ] }, "reaction_10548055": { "compartment": "compartment_70101", "id": "reaction_10548055", "reactome": "R-CEL-3772436", "name": "DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_392417" ], "products": [ "species_29370", "species_179856" ], "modifiers": [ [ "species_10548042", "catalyst" ] ], "additional_components": [ "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "O01759", "WBGene00004087" ] }, "reaction_10515100": { "compartment": "compartment_70101", "id": "reaction_10515100", "reactome": "R-CEL-201717", "name": "CSNK2-mediated phosphorylation of DVL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10515052", "species_113592" ], "products": [ "species_29370", "species_10515075" ], "modifiers": [ [ "species_10515097", "catalyst" ] ], "additional_components": [ "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "P18334", "WBGene00002191", "P28548", "WBGene00002196" ] }, "reaction_10548044": { "compartment": "compartment_70101", "id": "reaction_10548044", "reactome": "R-CEL-3772434", "name": "Phosphorylated DVL recruits PIP5K1B to the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10537053", "species_10515002" ], "products": [ "species_10548042" ], "modifiers": [], "additional_components": [ "WBGene00004087", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "O01759", "WBGene00004087" ] }, "reaction_10573013": { "compartment": "compartment_70101", "id": "reaction_10573013", "reactome": "R-CEL-9667965", "name": "ANKLE2 binds PP2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546138", "species_10529273" ], "products": [ "species_10573011" ], "modifiers": [], "additional_components": [ "WBGene00021945", "Q09543", "WBGene00003901", "G5EDR3", "WBGene00006352", "G5EGK8", "WBGene00002363", "Q09543", "WBGene00003901", "G5EDR3", "WBGene00006352", "G5EGK8", "WBGene00002363", "H2KZB2", "WBGene00021945" ] }, "reaction_10546149": { "compartment": "compartment_70101", "id": "reaction_10546149", "reactome": "R-CEL-2995389", "name": "ANKLE2 binds VRK1,(VRK2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546143", "species_10546138" ], "products": [ "species_10546147" ], "modifiers": [], "additional_components": [ "WBGene00017895", "WBGene00021945", "H2KZB2", "WBGene00021945", "Q19848", "WBGene00017895" ] }, "reaction_10572275": { "compartment": "compartment_1598585", "id": "reaction_10572275", "reactome": "R-CEL-9624845", "name": "RCC1 stimulates GDP to GTP exchange on RAN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10558002" ], "products": [ "species_29420", "species_10572267" ], "modifiers": [ [ "species_10572272", "catalyst" ] ], "additional_components": [ "O17915", "WBGene00004302", "species_29420", "O17915", "WBGene00004302", "species_29438", "WBGene00004304" ] }, "reaction_10572213": { "compartment": "compartment_70101", "id": "reaction_10572213", "reactome": "R-CEL-9618378", "name": "POM121 binds the Nup107-Nup160 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10507233", "species_10572209" ], "products": [ "species_10572211" ], "modifiers": [], "additional_components": [ "WBGene00003800", "P34343", "WBGene00003801", "Q17872", "WBGene00007493", "Q8T8M4", "WBGene00003792", "Q9N4A7", "WBGene00003806", "Q22078", "WBGene00003788", "O45933", "WBGene00003804", "Q19131", "WBGene00003791", "G5EEH9", "WBGene00003796", "P34343", "WBGene00003801", "Q17872", "WBGene00007493", "Q8T8M4", "WBGene00003792", "Q9N4A7", "WBGene00003806", "Q22078", "WBGene00003788", "O45933", "WBGene00003804", "Q19131", "WBGene00003791", "G5EEH9", "WBGene00003796", "Q17602", "WBGene00003800" ] }, "reaction_10572279": { "compartment": "compartment_70101", "id": "reaction_10572279", "reactome": "R-CEL-9624876", "name": "RAN:GTP recruits nuclear envelope (NE) membranes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9624879", "species_10572267" ], "products": [ "species_10572277" ], "modifiers": [], "additional_components": [ "O17915", "WBGene00004302", "species_29438", "O17915", "WBGene00004302", "species_29438" ] }, "reaction_10572282": { "compartment": "compartment_70101", "id": "reaction_10572282", "reactome": "R-CEL-9624893", "name": "RAN stimulates fusion of nuclear envelope (NE) membranes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10572277" ], "products": [ "species_29372", "species_9624890", "species_10558002" ], "modifiers": [ [ "species_10546252", "catalyst" ] ], "additional_components": [ "O17915", "WBGene00004302", "species_29438", "O17915", "WBGene00004302", "species_29420", "P34342", "WBGene00004303", "P55853", "WBGene00004888" ] }, "reaction_10573042": { "compartment": "compartment_70101", "id": "reaction_10573042", "reactome": "R-CEL-9668389", "name": "VPS4 binds ESCRT-III assemblies at nuclear envelope (NE) fenestrations", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10573038", "species_10573033" ], "products": [ "species_10573040" ], "modifiers": [], "additional_components": [ "WBGene00021334", "Q9U2M8", "WBGene00012578", "G5ECX8", "WBGene00010736", "Q9XTB5", "WBGene00002275", "Q9GYK4", "WBGene00020866", "Q9BL60", "WBGene00022027", "Q9U2F6", "WBGene00012903", "O02208", "WBGene00007216", "Q22718", "WBGene00011976", "Q18886", "WBGene00016961", "Q21959", "WBGene00020025", "Q8MNV0", "WBGene00016045", "Q9U2M8", "WBGene00012578", "G5ECX8", "WBGene00010736", "Q9XTB5", "WBGene00002275", "Q9GYK4", "WBGene00020866", "Q9BL60", "WBGene00022027", "Q9U2F6", "WBGene00012903", "O02208", "WBGene00007216", "Q22718", "WBGene00011976", "Q18886", "WBGene00016961", "Q21959", "WBGene00020025", "Q8MNV0", "WBGene00016045", "Q9BL83", "WBGene00021334" ] }, "reaction_10573044": { "compartment": "compartment_13231", "id": "reaction_10573044", "reactome": "R-CEL-9668395", "name": "CHMP7 binds CC2D1B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10573029", "species_10573025" ], "products": [ "species_10573031" ], "modifiers": [], "additional_components": [ "G5ECX8", "WBGene00010736", "Q9XTB5", "WBGene00002275", "Q9GYK4", "WBGene00020866", "Q9BL60", "WBGene00022027", "Q9U2F6", "WBGene00012903", "O02208", "WBGene00007216", "Q22718", "WBGene00011976", "Q18886", "WBGene00016961", "Q21959", "WBGene00020025", "WBGene00012578", "Q9U2M8", "WBGene00012578", "G5ECX8", "WBGene00010736", "Q9XTB5", "WBGene00002275", "Q9GYK4", "WBGene00020866", "Q9BL60", "WBGene00022027", "Q9U2F6", "WBGene00012903", "O02208", "WBGene00007216", "Q22718", "WBGene00011976", "Q18886", "WBGene00016961", "Q21959", "WBGene00020025" ] }, "reaction_10573046": { "compartment": "compartment_70101", "id": "reaction_10573046", "reactome": "R-CEL-9668405", "name": "SPAST (spastin) binds the IST1 subunit of ESCRT-III at the sites of microtubule attachment to chromatin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10573020", "species_10573031" ], "products": [ "species_10573033" ], "modifiers": [], "additional_components": [ "WBGene00016045", "Q9U2M8", "WBGene00012578", "G5ECX8", "WBGene00010736", "Q9XTB5", "WBGene00002275", "Q9GYK4", "WBGene00020866", "Q9BL60", "WBGene00022027", "Q9U2F6", "WBGene00012903", "O02208", "WBGene00007216", "Q22718", "WBGene00011976", "Q18886", "WBGene00016961", "Q21959", "WBGene00020025", "Q9U2M8", "WBGene00012578", "G5ECX8", "WBGene00010736", "Q9XTB5", "WBGene00002275", "Q9GYK4", "WBGene00020866", "Q9BL60", "WBGene00022027", "Q9U2F6", "WBGene00012903", "O02208", "WBGene00007216", "Q22718", "WBGene00011976", "Q18886", "WBGene00016961", "Q21959", "WBGene00020025", "Q8MNV0", "WBGene00016045" ] }, "reaction_10544436": { "compartment": "compartment_70101", "id": "reaction_10544436", "reactome": "R-CEL-2467775", "name": "Autocleavage of ESPL1 (Separase)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10544425" ], "products": [ "species_10544433" ], "modifiers": [ [ "species_10544425", "catalyst" ] ], "additional_components": [ "WBGene00004775", "G5ED39", "WBGene00004775", "WBGene00004775" ] }, "reaction_10509875": { "compartment": "compartment_7660", "id": "reaction_10509875", "reactome": "R-CEL-156682", "name": "PLK1 phosphorylates NUDC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509869", "species_113592" ], "products": [ "species_29370", "species_10509873" ], "modifiers": [ [ "species_10509861", "catalyst" ] ], "additional_components": [ "WBGene00003829", "WBGene00003829", "WBGene00004043" ] }, "reaction_10572564": { "compartment": "compartment_70101", "id": "reaction_10572564", "reactome": "R-CEL-9647746", "name": "EML4 trimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10572560" ], "products": [ "species_10572562" ], "modifiers": [], "additional_components": [ "WBGene00001248", "O45487", "WBGene00001248" ] }, "reaction_10544760": { "compartment": "compartment_70101", "id": "reaction_10544760", "reactome": "R-CEL-2529015", "name": "Dephosphorylation of CK2-modified condensin I", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10544748" ], "products": [ "species_29372", "species_10544758" ], "modifiers": [ [ "species_2529006", "catalyst" ] ], "additional_components": [ "G5EFJ4", "WBGene00009254", "Q20060", "WBGene00004874", "Q09591", "WBGene00003367", "Q9U2M1", "WBGene00001087", "G5EFJ4", "WBGene00009254", "Q20060", "WBGene00004874", "Q09591", "WBGene00003367", "Q9U2M1", "WBGene00001087" ] }, "reaction_10544762": { "compartment": "compartment_70101", "id": "reaction_10544762", "reactome": "R-CEL-2529020", "name": "CK2 phosphorylates condensin I subunits", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10544758" ], "products": [ "species_10544748", "species_29370" ], "modifiers": [ [ "species_10515097", "catalyst" ] ], "additional_components": [ "G5EFJ4", "WBGene00009254", "Q20060", "WBGene00004874", "Q09591", "WBGene00003367", "Q9U2M1", "WBGene00001087", "G5EFJ4", "WBGene00009254", "Q20060", "WBGene00004874", "Q09591", "WBGene00003367", "Q9U2M1", "WBGene00001087", "P18334", "WBGene00002191", "P28548", "WBGene00002196" ] }, "reaction_10544517": { "compartment": "compartment_1598585", "id": "reaction_10544517", "reactome": "R-CEL-2468293", "name": "CDK1 phosphorylates CDCA5 (Sororin) at chromosomal arms", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10544514" ], "products": [ "species_29370", "species_10544390" ], "modifiers": [ [ "species_10511266", "catalyst" ] ], "additional_components": [ "H2L0H5", "WBGene00019953", "B2FDA8", "WBGene00004873", "Q19555", "WBGene00004738", "O01789", "WBGene00001860", "Q19325", "WBGene00004737", "Q9XUB3", "WBGene00004333", "G5EC05", "WBGene00001352", "H2L0H5", "WBGene00019953", "B2FDA8", "WBGene00004873", "Q19555", "WBGene00004738", "O01789", "WBGene00001860", "Q19325", "WBGene00004737", "Q9XUB3", "WBGene00004333", "G5EC05", "WBGene00001352", "Q10653", "WBGene00000865", "P34556", "WBGene00000405", "Q9BLB5", "WBGene00000867", "O45926", "WBGene00000866" ] }, "reaction_10544410": { "compartment": "compartment_1598585", "id": "reaction_10544410", "reactome": "R-CEL-2466068", "name": "Phosphorylation of cohesin by PLK1 at chromosomal arms", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10544390" ], "products": [ "species_29370", "species_10544407" ], "modifiers": [ [ "species_10511228", "catalyst" ] ], "additional_components": [ "H2L0H5", "WBGene00019953", "B2FDA8", "WBGene00004873", "Q19555", "WBGene00004738", "O01789", "WBGene00001860", "Q19325", "WBGene00004737", "Q9XUB3", "WBGene00004333", "G5EC05", "WBGene00001352", "H2L0H5", "WBGene00019953", "Q19325", "WBGene00004737", "Q9XUB3", "WBGene00004333", "B2FDA8", "WBGene00004873", "Q19555", "WBGene00004738", "O01789", "WBGene00001860", "G5EC05", "WBGene00001352", "WBGene00004043" ] }, "reaction_10544537": { "compartment": "compartment_1598585", "id": "reaction_10544537", "reactome": "R-CEL-2470935", "name": "Cohesin binding to decondensed chromatin is facilitated by NIPBL:MAU2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2537690", "species_10544484", "species_10544529" ], "products": [ "species_10544535" ], "modifiers": [], "additional_components": [ "H2L0H5", "WBGene00019953", "B2FDA8", "WBGene00004873", "Q19325", "WBGene00004737", "Q9XUB3", "WBGene00004333", "Q19555", "WBGene00004738", "O01789", "WBGene00001860", "G5EC05", "WBGene00001352", "O17581", "WBGene00003136", "Q95XZ5", "WBGene00004166", "O17581", "WBGene00003136", "Q95XZ5", "WBGene00004166", "H2L0H5", "WBGene00019953", "B2FDA8", "WBGene00004873", "Q19325", "WBGene00004737", "Q9XUB3", "WBGene00004333", "Q19555", "WBGene00004738", "O01789", "WBGene00001860", "G5EC05", "WBGene00001352" ] }, "reaction_10544508": { "compartment": "compartment_7660", "id": "reaction_10544508", "reactome": "R-CEL-2468040", "name": "Cohesin binds PDS5 and WAPAL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10544478", "species_10544476", "species_10544482" ], "products": [ "species_10544484" ], "modifiers": [], "additional_components": [ "WBGene00001352", "B2FDA8", "WBGene00004873", "Q19325", "WBGene00004737", "Q9XUB3", "WBGene00004333", "Q19555", "WBGene00004738", "O01789", "WBGene00001860", "WBGene00019953", "H2L0H5", "WBGene00019953", "B2FDA8", "WBGene00004873", "Q19325", "WBGene00004737", "Q9XUB3", "WBGene00004333", "Q19555", "WBGene00004738", "O01789", "WBGene00001860", "G5EC05", "WBGene00001352" ] }, "reaction_10509854": { "compartment": "compartment_7660", "id": "reaction_10509854", "reactome": "R-CEL-156673", "name": "Regulation of KIF23 (MKLP1) by phosphorylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10509841" ], "products": [ "species_113582", "species_10509845" ], "modifiers": [ [ "species_10509851", "catalyst" ] ], "additional_components": [ "WBGene00006974", "WBGene00006974", "WBGene00004043" ] }, "reaction_10569693": { "compartment": "compartment_17957", "id": "reaction_10569693", "reactome": "R-CEL-8952289", "name": "FAM20C phosphorylates FAM20C substrates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8931885", "species_10569440" ], "products": [ "species_10569686", "species_8931884" ], "modifiers": [ [ "species_10569440", "catalyst" ], [ "species_10569691", "catalyst" ] ], "additional_components": [ "Q9XTW2", "WBGene00010356", "P49713", "WBGene00012225", "Q22235", "WBGene00011480", "G5EFD9", "WBGene00006324", "H2L2L3", "WBGene00013326", "Q10651", "WBGene00000149", "G5EFX3", "WBGene00013416", "Q9XWD6", "WBGene00000415", "O44565", "WBGene00002247", "Q18823", "WBGene00016913", "Q17770", "WBGene00003963", "A9Z1L1", "WBGene00005648", "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "Q8WQF8", "WBGene00017220", "Q8WQF7", "WBGene00017220", "Q9GZD8", "WBGene00235368", "O01330", "WBGene00235368", "Q9GZD9", "WBGene00235368", "O01331", "WBGene00235368", "Q9GZE0", "WBGene00235368", "P36573", "WBGene00002264", "Q9N384", "WBGene00002269", "C4RVF6", "WBGene00235368", "Q09581", "WBGene00002266", "U4PM93", "WBGene00235368", "G5EFI4", "WBGene00002268", "Q18625", "WBGene00002267", "K8ERT0", "WBGene00235368", "Q20684", "WBGene00002265", "O01329", "WBGene00235368", "G5EBY8", "WBGene00006852", "G5EEL5", "WBGene00000936", "Q8MQ51", "WBGene00009674", "K8F7Z5", "WBGene00008735", "Q7YTU0", "WBGene00013969", "Q11067", "WBGene00015168", "Q11186", "WBGene00015484", "G5EC87", "WBGene00014249", "H2KZY5", "WBGene00018533", "G5EBH7", "WBGene00019760", "Q19687", "WBGene00009008", "P50605", "WBGene00004749", "G5ECM9", "WBGene00000534", "P34714", "WBGene00003893", "Q9N3E0", "WBGene00001046", "Q09EE8", "WBGene00044988", "Q5ZR75", "WBGene00020516", "Q9BL47", "WBGene00022175", "Q18096", "WBGene00007687", "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769", "Q9XTW2", "WBGene00010356", "G5EFD9", "WBGene00006324", "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "H2L2L3", "WBGene00013326", "P49713", "WBGene00012225", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "A9Z1L1", "WBGene00005648", "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "Q10651", "WBGene00000149", "Q9GZE0", "WBGene00235368", "Q9N384", "WBGene00002269", "K8ERT0", "WBGene00235368", "O01329", "WBGene00235368", "U4PM93", "WBGene00235368", "O01330", "WBGene00235368", "O01331", "WBGene00235368", "P36573", "WBGene00002264", "Q09581", "WBGene00002266", "Q18625", "WBGene00002267", "Q20684", "WBGene00002265", "Q9GZD8", "WBGene00235368", "Q9GZD9", "WBGene00235368", "C4RVF6", "WBGene00235368", "G5EFI4", "WBGene00002268", "Q8MQ51", "WBGene00009674", "G5EFX3", "WBGene00013416", "Q9XWD6", "WBGene00000415", "Q17770", "WBGene00003963", "Q8WQF7", "WBGene00017220", "Q8WQF8", "WBGene00017220", "Q22235", "WBGene00011480", "Q11067", "WBGene00015168", "O44565", "WBGene00002247", "Q11186", "WBGene00015484", "G5EC87", "WBGene00014249", "Q18823", "WBGene00016913", "G5EBY8", "WBGene00006852", "G5EEL5", "WBGene00000936", "H2KZY5", "WBGene00018533", "P50605", "WBGene00004749", "Q7YTU0", "WBGene00013969", "K8F7Z5", "WBGene00008735", "P34714", "WBGene00003893", "G5EBH7", "WBGene00019760", "Q09EE8", "WBGene00044988", "Q19687", "WBGene00009008", "Q9BL47", "WBGene00022175", "G5ECM9", "WBGene00000534", "Q18096", "WBGene00007687", "Q9N3E0", "WBGene00001046", "Q5ZR75", "WBGene00020516", "Q9XTW2", "WBGene00010356", "P49713", "WBGene00012225", "Q22235", "WBGene00011480", "G5EFD9", "WBGene00006324", "H2L2L3", "WBGene00013326", "Q10651", "WBGene00000149", "G5EFX3", "WBGene00013416", "Q9XWD6", "WBGene00000415", "O44565", "WBGene00002247", "Q18823", "WBGene00016913", "Q17770", "WBGene00003963", "A9Z1L1", "WBGene00005648", "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "Q8WQF8", "WBGene00017220", "Q8WQF7", "WBGene00017220", "Q9GZD8", "WBGene00235368", "O01330", "WBGene00235368", "Q9GZD9", "WBGene00235368", "O01331", "WBGene00235368", "Q9GZE0", "WBGene00235368", "P36573", "WBGene00002264", "Q9N384", "WBGene00002269", "C4RVF6", "WBGene00235368", "Q09581", "WBGene00002266", "U4PM93", "WBGene00235368", "G5EFI4", "WBGene00002268", "Q18625", "WBGene00002267", "K8ERT0", "WBGene00235368", "Q20684", "WBGene00002265", "O01329", "WBGene00235368", "G5EBY8", "WBGene00006852", "G5EEL5", "WBGene00000936", "Q8MQ51", "WBGene00009674", "K8F7Z5", "WBGene00008735", "Q7YTU0", "WBGene00013969", "Q11067", "WBGene00015168", "Q11186", "WBGene00015484", "G5EC87", "WBGene00014249", "H2KZY5", "WBGene00018533", "G5EBH7", "WBGene00019760", "Q19687", "WBGene00009008", "P50605", "WBGene00004749", "G5ECM9", "WBGene00000534", "P34714", "WBGene00003893", "Q9N3E0", "WBGene00001046", "Q09EE8", "WBGene00044988", "Q5ZR75", "WBGene00020516", "Q9BL47", "WBGene00022175", "Q18096", "WBGene00007687", "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769", "Q9XTW2", "WBGene00010356" ] }, "reaction_10554323": { "compartment": "compartment_70101", "id": "reaction_10554323", "reactome": "R-CEL-5653957", "name": "Rag dimer formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10510565", "species_10510578" ], "products": [ "species_10510580" ], "modifiers": [], "additional_components": [ "Q22743", "WBGene00006414", "species_29438", "species_29420", "G5EGB3", "WBGene00012497", "species_29420", "G5EGB3", "WBGene00012497", "Q22743", "WBGene00006414", "species_29438" ] }, "reaction_10554325": { "compartment": "compartment_17938", "id": "reaction_10554325", "reactome": "R-CEL-5653968", "name": "Ragulator:Rag dimers:SLC38A9 bind mTORC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10510526", "species_10510584" ], "products": [ "species_10510586" ], "modifiers": [], "additional_components": [ "P91040", "WBGene00015697", "Q95Q95", "WBGene00002583", "Q68TI8", "WBGene00000911", "Q19425", "WBGene00008774", "species_29420", "G5EGB3", "WBGene00012497", "Q22743", "WBGene00006414", "species_29438", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "Q19425", "WBGene00008774", "species_29420", "G5EGB3", "WBGene00012497", "Q22743", "WBGene00006414", "species_29438", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "P91040", "WBGene00015697", "Q95Q95", "WBGene00002583", "Q68TI8", "WBGene00000911" ] }, "reaction_10554902": { "compartment": "compartment_17938", "id": "reaction_10554902", "reactome": "R-CEL-5672828", "name": "mTORC1 phosphorylates AKT1S1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10510629" ], "products": [ "species_29370", "species_10554899" ], "modifiers": [ [ "species_10510629", "catalyst" ] ], "additional_components": [ "Q19425", "WBGene00008774", "species_29420", "G5EGB3", "WBGene00012497", "Q22743", "WBGene00006414", "species_29438", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "P91040", "WBGene00015697", "Q95Q95", "WBGene00002583", "Q68TI8", "WBGene00000911", "P34443", "WBGene00010038", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "Q19425", "WBGene00008774", "species_29420", "G5EGB3", "WBGene00012497", "Q22743", "WBGene00006414", "species_29438", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "P91040", "WBGene00015697", "Q95Q95", "WBGene00002583", "Q68TI8", "WBGene00000911", "P34443", "WBGene00010038", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "Q19425", "WBGene00008774", "species_29420", "G5EGB3", "WBGene00012497", "Q22743", "WBGene00006414", "species_29438", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "P91040", "WBGene00015697", "Q95Q95", "WBGene00002583", "Q68TI8", "WBGene00000911", "P34443", "WBGene00010038", "P41932", "WBGene00003920", "Q20655", "WBGene00001502" ] }, "reaction_10569771": { "compartment": "compartment_70101", "id": "reaction_10569771", "reactome": "R-CEL-8952726", "name": "SLC38A9 transports L-Arg from lysosomal lumen to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428011" ], "products": [ "species_29468" ], "modifiers": [ [ "species_10510584", "catalyst" ] ], "additional_components": [ "Q19425", "WBGene00008774", "species_29420", "G5EGB3", "WBGene00012497", "Q22743", "WBGene00006414", "species_29438", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390" ] }, "reaction_10554893": { "compartment": "compartment_17938", "id": "reaction_10554893", "reactome": "R-CEL-5672824", "name": "Phosphorylated AKT1S1:mTORC1 binds YWHAB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10507065", "species_10510627" ], "products": [ "species_10510629" ], "modifiers": [], "additional_components": [ "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "Q19425", "WBGene00008774", "species_29420", "G5EGB3", "WBGene00012497", "Q22743", "WBGene00006414", "species_29438", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "P91040", "WBGene00015697", "Q95Q95", "WBGene00002583", "Q68TI8", "WBGene00000911", "P34443", "WBGene00010038", "Q19425", "WBGene00008774", "species_29420", "G5EGB3", "WBGene00012497", "Q22743", "WBGene00006414", "species_29438", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "P91040", "WBGene00015697", "Q95Q95", "WBGene00002583", "Q68TI8", "WBGene00000911", "P34443", "WBGene00010038", "P41932", "WBGene00003920", "Q20655", "WBGene00001502" ] }, "reaction_10510643": { "compartment": "compartment_70101", "id": "reaction_10510643", "reactome": "R-CEL-165726", "name": "Phosphorylation of Ribosomal protein S6 by activated S6K1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10505506" ], "products": [ "species_29370", "species_10510640" ], "modifiers": [ [ "species_10510612", "catalyst" ] ], "additional_components": [ "WBGene00004475", "WBGene00004475", "Q9NAH6", "WBGene00012929", "Q21694", "WBGene00044281" ] }, "reaction_10510660": { "compartment": "compartment_70101", "id": "reaction_10510660", "reactome": "R-CEL-165766", "name": "Phosphorylation and activation of eIF4G by activated S6K1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10505665" ], "products": [ "species_29370", "species_10510658" ], "modifiers": [ [ "species_10510612", "catalyst" ] ], "additional_components": [ "WBGene00002066", "WBGene00002066", "Q9NAH6", "WBGene00012929", "Q21694", "WBGene00044281" ] }, "reaction_10510631": { "compartment": "compartment_17938", "id": "reaction_10510631", "reactome": "R-CEL-165718", "name": "mTORC1 phosphorylation of RPS6KB1 (S6K)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10510602", "species_113592" ], "products": [ "species_29370", "species_10510612" ], "modifiers": [ [ "species_10510588", "catalyst" ], [ "species_10510629", "catalyst" ], [ "species_10510623", "inhibitor" ] ], "additional_components": [ "Q21694", "WBGene00044281", "Q9NAH6", "WBGene00012929", "Q9NAH6", "WBGene00012929", "Q21694", "WBGene00044281", "Q19425", "WBGene00008774", "species_29420", "G5EGB3", "WBGene00012497", "Q22743", "WBGene00006414", "species_29438", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "P91040", "WBGene00015697", "Q95Q95", "WBGene00002583", "Q68TI8", "WBGene00000911", "P34443", "WBGene00010038", "Q19425", "WBGene00008774", "species_29420", "G5EGB3", "WBGene00012497", "Q22743", "WBGene00006414", "species_29438", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "P91040", "WBGene00015697", "Q95Q95", "WBGene00002583", "Q68TI8", "WBGene00000911", "P34443", "WBGene00010038", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "P34443", "WBGene00010038", "species_29438", "Q19425", "WBGene00008774", "species_29420", "G5EGB3", "WBGene00012497", "Q22743", "WBGene00006414", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "P91040", "WBGene00015697", "Q95Q95", "WBGene00002583", "Q68TI8", "WBGene00000911" ] }, "reaction_10510665": { "compartment": "compartment_70101", "id": "reaction_10510665", "reactome": "R-CEL-165777", "name": "Phosphorylation and activation of eIF4B by activated S6K1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10505672" ], "products": [ "species_29370", "species_10510663" ], "modifiers": [ [ "species_10510612", "catalyst" ] ], "additional_components": [ "WBGene00019157", "WBGene00019157", "Q9NAH6", "WBGene00012929", "Q21694", "WBGene00044281" ] }, "reaction_10510653": { "compartment": "compartment_70101", "id": "reaction_10510653", "reactome": "R-CEL-165758", "name": "Phosphorylation and inactivation of eEF2K by activated S6K1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10510648" ], "products": [ "species_10510651", "species_29370" ], "modifiers": [ [ "species_10510612", "catalyst" ] ], "additional_components": [ "WBGene00001160", "WBGene00001160", "Q9NAH6", "WBGene00012929", "Q21694", "WBGene00044281" ] }, "reaction_10519956": { "compartment": "compartment_70101", "id": "reaction_10519956", "reactome": "R-CEL-380930", "name": "Phosphorylated AMPK binds AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10514570", "species_76577" ], "products": [ "species_10519954" ], "modifiers": [], "additional_components": [ "Q9XUY2", "WBGene00010115", "P45894", "WBGene00019801", "Q95ZQ4", "WBGene00020142", "A0A1T5HUK9", "WBGene00013732", "H2L0K0", "WBGene00020135", "O02168", "WBGene00020633", "Q9N501", "WBGene00021527", "species_76577", "Q9XUY2", "WBGene00010115", "P45894", "WBGene00019801", "Q95ZQ4", "WBGene00020142", "A0A1T5HUK9", "WBGene00013732", "H2L0K0", "WBGene00020135", "O02168", "WBGene00020633", "Q9N501", "WBGene00021527" ] }, "reaction_10525223": { "compartment": "compartment_876", "id": "reaction_10525223", "reactome": "R-CEL-447074", "name": "AMPK phosphorylates Raptor in the mTORC1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10510588", "species_113592" ], "products": [ "species_10510623", "species_29370" ], "modifiers": [ [ "species_10519954", "catalyst" ] ], "additional_components": [ "Q19425", "WBGene00008774", "species_29420", "G5EGB3", "WBGene00012497", "Q22743", "WBGene00006414", "species_29438", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "P91040", "WBGene00015697", "Q95Q95", "WBGene00002583", "Q68TI8", "WBGene00000911", "P34443", "WBGene00010038", "P34443", "WBGene00010038", "species_29438", "Q19425", "WBGene00008774", "species_29420", "G5EGB3", "WBGene00012497", "Q22743", "WBGene00006414", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "P91040", "WBGene00015697", "Q95Q95", "WBGene00002583", "Q68TI8", "WBGene00000911", "species_76577", "Q9XUY2", "WBGene00010115", "P45894", "WBGene00019801", "Q95ZQ4", "WBGene00020142", "A0A1T5HUK9", "WBGene00013732", "H2L0K0", "WBGene00020135", "O02168", "WBGene00020633", "Q9N501", "WBGene00021527" ] }, "reaction_10519961": { "compartment": "compartment_70101", "id": "reaction_10519961", "reactome": "R-CEL-380949", "name": "AMPK is dephosphorylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10514570" ], "products": [ "species_29372", "species_10514555" ], "modifiers": [ [ "species_10519958", "catalyst" ] ], "additional_components": [ "Q9XUY2", "WBGene00010115", "P45894", "WBGene00019801", "Q95ZQ4", "WBGene00020142", "A0A1T5HUK9", "WBGene00013732", "H2L0K0", "WBGene00020135", "O02168", "WBGene00020633", "Q9N501", "WBGene00021527", "Q9XUY2", "WBGene00010115", "A0A1T5HUK9", "WBGene00013732", "H2L0K0", "WBGene00020135", "O02168", "WBGene00020633", "Q9N501", "WBGene00021527", "P45894", "WBGene00019801", "Q95ZQ4", "WBGene00020142", "WBGene00006460" ] }, "reaction_10510509": { "compartment": "compartment_17938", "id": "reaction_10510509", "reactome": "R-CEL-165195", "name": "GTP loading by Rheb", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10510505" ], "products": [ "species_29420", "species_10510507" ], "modifiers": [], "additional_components": [ "P34443", "WBGene00010038", "species_29420", "P34443", "WBGene00010038", "species_29438" ] }, "reaction_10510590": { "compartment": "compartment_70101", "id": "reaction_10510590", "reactome": "R-CEL-165680", "name": "Formation of active mTORC1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10510507", "species_10510586" ], "products": [ "species_10510588" ], "modifiers": [], "additional_components": [ "P34443", "WBGene00010038", "species_29438", "Q19425", "WBGene00008774", "species_29420", "G5EGB3", "WBGene00012497", "Q22743", "WBGene00006414", "species_29438", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "P91040", "WBGene00015697", "Q95Q95", "WBGene00002583", "Q68TI8", "WBGene00000911", "Q19425", "WBGene00008774", "species_29420", "G5EGB3", "WBGene00012497", "Q22743", "WBGene00006414", "species_29438", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "P91040", "WBGene00015697", "Q95Q95", "WBGene00002583", "Q68TI8", "WBGene00000911", "P34443", "WBGene00010038" ] }, "reaction_10519535": { "compartment": "compartment_17938", "id": "reaction_10519535", "reactome": "R-CEL-377186", "name": "Activated Akt1 phosphorylates AKT1S1 (PRAS40)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10519532", "species_113592" ], "products": [ "species_29370", "species_10510627" ], "modifiers": [ [ "species_10515152", "catalyst" ] ], "additional_components": [ "Q19425", "WBGene00008774", "species_29420", "G5EGB3", "WBGene00012497", "Q22743", "WBGene00006414", "species_29438", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "P91040", "WBGene00015697", "Q95Q95", "WBGene00002583", "Q68TI8", "WBGene00000911", "P34443", "WBGene00010038", "Q19425", "WBGene00008774", "species_29420", "G5EGB3", "WBGene00012497", "Q22743", "WBGene00006414", "species_29438", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "P91040", "WBGene00015697", "Q95Q95", "WBGene00002583", "Q68TI8", "WBGene00000911", "P34443", "WBGene00010038", "G4S4W1", "WBGene00016980", "Q17941", "WBGene00000102", "Q9XTG7", "WBGene00000103" ] }, "reaction_10509895": { "compartment": "compartment_70101", "id": "reaction_10509895", "reactome": "R-CEL-156823", "name": "Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509886", "species_10509891" ], "products": [ "species_10509893" ], "modifiers": [], "additional_components": [ "A0A486WX07", "WBGene00002066", "Q20935", "WBGene00018997", "P27639", "WBGene00002083", "O61955", "WBGene00002061", "species_29438", "Q9BKU3", "WBGene00021351", "Q21230", "WBGene00010560", "Q95XR0", "WBGene00021466", "P51403", "WBGene00004471", "Q9NEN6", "WBGene00004475", "Q8WQA8", "WBGene00004489", "Q23312", "WBGene00004476", "O01869", "WBGene00004479", "P49197", "WBGene00004490", "P48156", "WBGene00004477", "Q20206", "WBGene00004480", "Q19877", "WBGene00004492", "Q20228", "WBGene00004478", "P49196", "WBGene00004481", "Q1XFY9", "WBGene00004493", "P46769", "WBGene00004469", "P51404", "WBGene00004482", "P52821", "WBGene00004494", "Q9TXP0", "WBGene00004496", "P48150", "WBGene00004483", "O45499", "WBGene00004495", "Q9N3X2", "WBGene00004473", "Q9XVP0", "WBGene00004484", "Q95Y04", "WBGene00004497", "Q22054", "WBGene00004485", "P90983", "WBGene00004498", "O01692", "WBGene00004486", "P48152", "WBGene00004472", "O18240", "WBGene00004487", "O18650", "WBGene00004488", "P48154", "WBGene00004470", "O17218", "WBGene00004491", "P49041", "WBGene00004474", "Q95QW0", "WBGene00015920", "O01974", "WBGene00001231", "Q94261", "WBGene00019543", "P34339", "WBGene00001209", "Q9XWP7", "WBGene00012738", "P30642", "WBGene00001227", "Q965S8", "WBGene00001232", "O02328", "WBGene00001226", "Q19706", "WBGene00001230", "O61820", "WBGene00001228", "Q18967", "WBGene00001229", "Q9XUP3", "WBGene00001233", "Q9XWI6", "WBGene00001225", "Q9TXU7", "WBGene00019162", "H2L0A8", "WBGene00019157", "Q9U302", "WBGene00003902", "WBGene00004428", "Q27389", "WBGene00004428", "A0A486WX07", "WBGene00002066", "Q20935", "WBGene00018997", "P27639", "WBGene00002083", "O61955", "WBGene00002061", "species_29438", "Q9BKU3", "WBGene00021351", "Q21230", "WBGene00010560", "Q95XR0", "WBGene00021466", "P51403", "WBGene00004471", "Q9NEN6", "WBGene00004475", "Q8WQA8", "WBGene00004489", "Q23312", "WBGene00004476", "O01869", "WBGene00004479", "P49197", "WBGene00004490", "P48156", "WBGene00004477", "Q20206", "WBGene00004480", "Q19877", "WBGene00004492", "Q20228", "WBGene00004478", "P49196", "WBGene00004481", "Q1XFY9", "WBGene00004493", "P46769", "WBGene00004469", "P51404", "WBGene00004482", "P52821", "WBGene00004494", "Q9TXP0", "WBGene00004496", "P48150", "WBGene00004483", "O45499", "WBGene00004495", "Q9N3X2", "WBGene00004473", "Q9XVP0", "WBGene00004484", "Q95Y04", "WBGene00004497", "Q22054", "WBGene00004485", "P90983", "WBGene00004498", "O01692", "WBGene00004486", "P48152", "WBGene00004472", "O18240", "WBGene00004487", "O18650", "WBGene00004488", "P48154", "WBGene00004470", "O17218", "WBGene00004491", "P49041", "WBGene00004474", "Q95QW0", "WBGene00015920", "O01974", "WBGene00001231", "Q94261", "WBGene00019543", "P34339", "WBGene00001209", "Q9XWP7", "WBGene00012738", "P30642", "WBGene00001227", "Q965S8", "WBGene00001232", "O02328", "WBGene00001226", "Q19706", "WBGene00001230", "O61820", "WBGene00001228", "Q18967", "WBGene00001229", "Q9XUP3", "WBGene00001233", "Q9XWI6", "WBGene00001225", "Q9TXU7", "WBGene00019162", "H2L0A8", "WBGene00019157", "Q9U302", "WBGene00003902" ] }, "reaction_10509899": { "compartment": "compartment_70101", "id": "reaction_10509899", "reactome": "R-CEL-156826", "name": "Dissociation of L13a from the 60s ribosomal subunit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10505970" ], "products": [ "species_10509897", "species_10505768" ], "modifiers": [], "additional_components": [ "P91914", "WBGene00004441", "Q19869", "WBGene00004440", "O01868", "WBGene00004436", "P48162", "WBGene00004438", "P52819", "WBGene00004434", "P48158", "WBGene00004435", "Q09533", "WBGene00004421", "P34334", "WBGene00004433", "O02639", "WBGene00004431", "Q95Y90", "WBGene00004420", "O44480", "WBGene00004432", "Q22716", "WBGene00004446", "Q9U332", "WBGene00004445", "Q9XWS4", "WBGene00004444", "P52814", "WBGene00004453", "O45226", "WBGene00004443", "Q21930", "WBGene00004442", "P48166", "WBGene00004454", "Q9BKU5", "WBGene00021350", "P50880", "WBGene00004414", "P61866", "WBGene00004424", "O17570", "WBGene00004452", "Q19162", "WBGene00004423", "Q9U2A8", "WBGene00004456", "Q9N4I4", "WBGene00004412", "O62388", "WBGene00012179", "O01504", "WBGene00016493", "P49181", "WBGene00004450", "P91913", "WBGene00004409", "P49180", "WBGene00004447", "Q93572", "WBGene00004408", "P34662", "WBGene00004449", "Q9XVF7", "WBGene00004413", "O45946", "WBGene00004430", "Q966C6", "WBGene00004419", "Q9BL19", "WBGene00004429", "O01802", "WBGene00004418", "P91374", "WBGene00004427", "P47991", "WBGene00004417", "Q9XVE9", "WBGene00004426", "P49405", "WBGene00004416", "Q27389", "WBGene00004428", "P37165", "WBGene00006725", "P91128", "WBGene00004425", "O02056", "WBGene00004415", "P91914", "WBGene00004441", "Q19869", "WBGene00004440", "O01868", "WBGene00004436", "P48162", "WBGene00004438", "P52819", "WBGene00004434", "P48158", "WBGene00004435", "Q09533", "WBGene00004421", "P34334", "WBGene00004433", "O02639", "WBGene00004431", "Q95Y90", "WBGene00004420", "O44480", "WBGene00004432", "Q22716", "WBGene00004446", "Q9U332", "WBGene00004445", "Q9XWS4", "WBGene00004444", "P52814", "WBGene00004453", "O45226", "WBGene00004443", "Q21930", "WBGene00004442", "P48166", "WBGene00004454", "Q9BKU5", "WBGene00021350", "P50880", "WBGene00004414", "P61866", "WBGene00004424", "O17570", "WBGene00004452", "Q19162", "WBGene00004423", "Q9U2A8", "WBGene00004456", "Q9N4I4", "WBGene00004412", "O62388", "WBGene00012179", "O01504", "WBGene00016493", "P49181", "WBGene00004450", "P91913", "WBGene00004409", "P49180", "WBGene00004447", "Q93572", "WBGene00004408", "P34662", "WBGene00004449", "Q9XVF7", "WBGene00004413", "O45946", "WBGene00004430", "Q966C6", "WBGene00004419", "Q9BL19", "WBGene00004429", "O01802", "WBGene00004418", "P91374", "WBGene00004427", "P47991", "WBGene00004417", "Q9XVE9", "WBGene00004426", "P49405", "WBGene00004416", "P37165", "WBGene00006725", "P91128", "WBGene00004425", "O02056", "WBGene00004415", "WBGene00004428" ] }, "reaction_10550786": { "compartment": "compartment_70101", "id": "reaction_10550786", "reactome": "R-CEL-5228992", "name": "ROCK1,ROCK2 are activated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10521951" ], "products": [ "species_10550784" ], "modifiers": [], "additional_components": [ "Q22038", "WBGene00004357", "species_29438", "P92199", "WBGene00002694", "Q21025", "WBGene00019087", "Q9XVH4", "WBGene00019087", "species_114632", "Q22038", "WBGene00004357", "species_29438", "P92199", "WBGene00002694", "Q21025", "WBGene00019087", "Q9XVH4", "WBGene00019087" ] }, "reaction_10550628": { "compartment": "compartment_876", "id": "reaction_10550628", "reactome": "R-CEL-5218812", "name": "FYN phosphorylates PAK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10550625" ], "products": [ "species_29370", "species_10550576" ], "modifiers": [ [ "species_10550625", "catalyst" ] ], "additional_components": [ "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "G5EGT9", "WBGene00003007", "A0A1I6CMA1", "WBGene00020678", "Q95PX0", "WBGene00006410", "Q05062", "WBGene00000390", "species_29438", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "G5EGT9", "WBGene00003007", "A0A1I6CMA1", "WBGene00020678", "Q95PX0", "WBGene00006410", "Q05062", "WBGene00000390", "species_29438", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "G5EGT9", "WBGene00003007", "A0A1I6CMA1", "WBGene00020678", "Q95PX0", "WBGene00006410", "Q05062", "WBGene00000390", "species_29438", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911" ] }, "reaction_10550693": { "compartment": "compartment_70101", "id": "reaction_10550693", "reactome": "R-CEL-5218916", "name": "p-MAPK2/3 phosphorylates HSP27", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10550685", "species_113592" ], "products": [ "species_10523755", "species_29370", "species_10550690" ], "modifiers": [ [ "species_10512646", "catalyst" ] ], "additional_components": [ "P0DM41", "WBGene00000063", "P0DM42", "WBGene00000065", "P10984", "WBGene00000064", "P10986", "WBGene00000066", "species_29358", "Q17849", "WBGene00002023", "P0DM41", "WBGene00000063", "P0DM42", "WBGene00000065", "P10984", "WBGene00000064", "P10986", "WBGene00000066", "species_29358", "WBGene00002023", "Q21360", "WBGene00010681", "Q965G5", "WBGene00007007" ] }, "reaction_10550665": { "compartment": "compartment_876", "id": "reaction_10550665", "reactome": "R-CEL-5218832", "name": "CDC42:GTP binds PAK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10550663", "species_10512279" ], "products": [ "species_10550636" ], "modifiers": [], "additional_components": [ "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "G5EGT9", "WBGene00003007", "A0A1I6CMA1", "WBGene00020678", "Q95PX0", "WBGene00006410", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "Q05062", "WBGene00000390", "species_29438", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "G5EGT9", "WBGene00003007", "A0A1I6CMA1", "WBGene00020678", "Q95PX0", "WBGene00006410", "Q05062", "WBGene00000390", "species_29438", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911" ] }, "reaction_10550667": { "compartment": "compartment_876", "id": "reaction_10550667", "reactome": "R-CEL-5218847", "name": "PAK2 binds NCK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10520680", "species_10550562" ], "products": [ "species_10550663" ], "modifiers": [], "additional_components": [ "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "G5EGT9", "WBGene00003007", "A0A1I6CMA1", "WBGene00020678", "Q95PX0", "WBGene00006410", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "G5EGT9", "WBGene00003007", "A0A1I6CMA1", "WBGene00020678", "Q95PX0", "WBGene00006410", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911" ] }, "reaction_10550639": { "compartment": "compartment_876", "id": "reaction_10550639", "reactome": "R-CEL-5218814", "name": "PAK2 autophorylates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10550636", "species_113592" ], "products": [ "species_29370", "species_10550625" ], "modifiers": [ [ "species_10550636", "catalyst" ] ], "additional_components": [ "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "G5EGT9", "WBGene00003007", "A0A1I6CMA1", "WBGene00020678", "Q95PX0", "WBGene00006410", "Q05062", "WBGene00000390", "species_29438", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "G5EGT9", "WBGene00003007", "A0A1I6CMA1", "WBGene00020678", "Q95PX0", "WBGene00006410", "Q05062", "WBGene00000390", "species_29438", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "G5EGT9", "WBGene00003007", "A0A1I6CMA1", "WBGene00020678", "Q95PX0", "WBGene00006410", "Q05062", "WBGene00000390", "species_29438", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911" ] }, "reaction_10550610": { "compartment": "compartment_70101", "id": "reaction_10550610", "reactome": "R-CEL-5218805", "name": "PKC autophosphorylates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10550592" ], "products": [ "species_10550607", "species_29370" ], "modifiers": [ [ "species_10550592", "catalyst" ] ], "additional_components": [ "Q19266", "WBGene00004034", "P90980", "WBGene00004033", "P34722", "WBGene00006599", "Q19266", "WBGene00004034", "P90980", "WBGene00004033", "P34722", "WBGene00006599", "Q19266", "WBGene00004034", "P90980", "WBGene00004033", "P34722", "WBGene00006599" ] }, "reaction_10550659": { "compartment": "compartment_876", "id": "reaction_10550659", "reactome": "R-CEL-5218823", "name": "PKC phosphorylates sphingosine kinase 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10520872" ], "products": [ "species_29370", "species_10550656" ], "modifiers": [ [ "species_10550630", "catalyst" ] ], "additional_components": [ "WBGene00007918", "WBGene00007918", "species_74016", "species_112275", "Q19266", "WBGene00004034", "P90980", "WBGene00004033", "P34722", "WBGene00006599" ] }, "reaction_10550653": { "compartment": "compartment_876", "id": "reaction_10550653", "reactome": "R-CEL-5218821", "name": "PDK1 phosphorylates PKC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10550650", "species_113592" ], "products": [ "species_29370", "species_10550592" ], "modifiers": [ [ "species_10508528", "catalyst" ] ], "additional_components": [ "P90980", "WBGene00004033", "Q19266", "WBGene00004034", "P34722", "WBGene00006599", "Q19266", "WBGene00004034", "P90980", "WBGene00004033", "P34722", "WBGene00006599", "WBGene00021022" ] }, "reaction_10550579": { "compartment": "compartment_70101", "id": "reaction_10550579", "reactome": "R-CEL-5218804", "name": "p38 MAPK activation by VEGFR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10526151" ], "products": [ "species_29370", "species_10512658" ], "modifiers": [ [ "species_10550576", "catalyst" ] ], "additional_components": [ "Q17446", "WBGene00004055", "Q8MXI4", "WBGene00004056", "species_114632", "Q17446", "WBGene00004055", "Q8MXI4", "WBGene00004056", "species_114632", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "G5EGT9", "WBGene00003007", "A0A1I6CMA1", "WBGene00020678", "Q95PX0", "WBGene00006410", "Q05062", "WBGene00000390", "species_29438", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911" ] }, "reaction_10548788": { "compartment": "compartment_876", "id": "reaction_10548788", "reactome": "R-CEL-3928647", "name": "RHOA:GTP:Mg2+ binds ROCK1,ROCK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10521949", "species_10509488" ], "products": [ "species_10521951" ], "modifiers": [], "additional_components": [ "P92199", "WBGene00002694", "Q21025", "WBGene00019087", "Q9XVH4", "WBGene00019087", "Q22038", "WBGene00004357", "species_29438", "Q22038", "WBGene00004357", "species_29438", "P92199", "WBGene00002694", "Q21025", "WBGene00019087", "Q9XVH4", "WBGene00019087" ] }, "reaction_10550644": { "compartment": "compartment_876", "id": "reaction_10550644", "reactome": "R-CEL-5218819", "name": "VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10550641", "catalyst" ] ], "additional_components": [ "G5EGT9", "WBGene00003007", "A0A1I6CMA1", "WBGene00020678", "G5EDP9", "WBGene00000001", "Q94125", "WBGene00000090" ] }, "reaction_10569044": { "compartment": "compartment_876", "id": "reaction_10569044", "reactome": "R-CEL-8951586", "name": "p-VAV family:PIP3 binds RAC1:GDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10541992", "species_10550646" ], "products": [ "species_10550669" ], "modifiers": [], "additional_components": [ "species_29420", "Q03206", "ced-10", "Q45FX5", "WBGene00006887", "species_179838", "Q45FX5", "WBGene00006887", "species_179838", "species_29420", "Q03206", "ced-10" ] }, "reaction_10551522": { "compartment": "compartment_876", "id": "reaction_10551522", "reactome": "R-CEL-5357445", "name": "PAK1-3 dimer disassociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10551518" ], "products": [ "species_10551520" ], "modifiers": [], "additional_components": [ "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "species_29438", "Q03206", "ced-10", "Q45FX5", "WBGene00006887", "species_179838", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "species_29438", "Q03206", "ced-10", "Q45FX5", "WBGene00006887", "species_179838" ] }, "reaction_10551525": { "compartment": "compartment_876", "id": "reaction_10551525", "reactome": "R-CEL-5357472", "name": "PAK1-3 autophosphorylates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10551520" ], "products": [ "species_10550671", "species_29370", "species_10521284" ], "modifiers": [ [ "species_10520686", "catalyst" ] ], "additional_components": [ "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "species_29438", "Q03206", "ced-10", "Q45FX5", "WBGene00006887", "species_179838", "species_29438", "Q03206", "ced-10", "Q45FX5", "WBGene00006887", "species_179838", "Q17850", "WBGene00003911", "G5EGQ3", "WBGene00003144", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911" ] }, "reaction_10551558": { "compartment": "compartment_876", "id": "reaction_10551558", "reactome": "R-CEL-5357477", "name": "PAK1-3 phosphorylates VE-cadherin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10551551", "species_113592" ], "products": [ "species_29370", "species_10551555" ], "modifiers": [ [ "species_10521284", "catalyst" ] ], "additional_components": [ "Q9U308", "WBGene00002175", "P90947", "WBGene00001978", "Q10953", "WBGene00006943", "Q18825", "WBGene00000238", "O44326", "WBGene00001979", "Q9U308", "WBGene00002175", "P90947", "WBGene00001978", "Q10953", "WBGene00006943", "Q18825", "WBGene00000238", "O44326", "WBGene00001979", "Q17850", "WBGene00003911", "G5EGQ3", "WBGene00003144" ] }, "reaction_10551560": { "compartment": "compartment_876", "id": "reaction_10551560", "reactome": "R-CEL-5357483", "name": "RAC1 binds PAK1-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10550671", "species_10520686" ], "products": [ "species_10551518" ], "modifiers": [], "additional_components": [ "species_29438", "Q03206", "ced-10", "Q45FX5", "WBGene00006887", "species_179838", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "species_29438", "Q03206", "ced-10", "Q45FX5", "WBGene00006887", "species_179838" ] }, "reaction_10515164": { "compartment": "compartment_70101", "id": "reaction_10515164", "reactome": "R-CEL-202111", "name": "AKT1 phosphorylates eNOS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10515154" ], "products": [ "species_29370", "species_10515162" ], "modifiers": [], "additional_components": [ "G4S4W1", "WBGene00016980", "Q17941", "WBGene00000102", "Q9XTG7", "WBGene00000103", "species_74016", "O16305", "WBGene00000552", "P04630", "WBGene00000285", "Q09665", "WBGene00006583", "A0A2C9C3L3", "WBGene00020378", "Q09980", "WBGene00017394", "G5EDZ8", "WBGene00000288", "Q11083", "WBGene00020378", "G5EEG0", "WBGene00000286", "Q18136", "WBGene00006861", "G5EF37", "WBGene00003934", "Q94288", "WBGene00000287", "O02159", "WBGene00020378", "species_71185", "species_216785", "species_73524", "species_113596", "Q18688", "WBGene00000915", "Q9XTG7", "WBGene00000103", "G4S4W1", "WBGene00016980", "Q17941", "WBGene00000102", "species_74016", "Q11083", "WBGene00020378", "P04630", "WBGene00000285", "G5EF37", "WBGene00003934", "A0A2C9C3L3", "WBGene00020378", "Q18136", "WBGene00006861", "Q09665", "WBGene00006583", "O02159", "WBGene00020378", "G5EDZ8", "WBGene00000288", "Q94288", "WBGene00000287", "Q09980", "WBGene00017394", "O16305", "WBGene00000552", "G5EEG0", "WBGene00000286", "Q18688", "WBGene00000915", "species_71185", "species_216785", "species_73524", "species_113596", "species_29870" ] }, "reaction_10535150": { "compartment": "compartment_70101", "id": "reaction_10535150", "reactome": "R-CEL-1497784", "name": "The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29870", "species_10515162" ], "products": [ "species_10515166" ], "modifiers": [], "additional_components": [ "Q9XTG7", "WBGene00000103", "G4S4W1", "WBGene00016980", "Q17941", "WBGene00000102", "species_74016", "Q11083", "WBGene00020378", "P04630", "WBGene00000285", "G5EF37", "WBGene00003934", "A0A2C9C3L3", "WBGene00020378", "Q18136", "WBGene00006861", "Q09665", "WBGene00006583", "O02159", "WBGene00020378", "G5EDZ8", "WBGene00000288", "Q94288", "WBGene00000287", "Q09980", "WBGene00017394", "O16305", "WBGene00000552", "G5EEG0", "WBGene00000286", "Q18688", "WBGene00000915", "species_71185", "species_216785", "species_73524", "species_113596", "species_29870", "Q9XTG7", "WBGene00000103", "G4S4W1", "WBGene00016980", "Q17941", "WBGene00000102", "species_74016", "Q11083", "WBGene00020378", "P04630", "WBGene00000285", "G5EF37", "WBGene00003934", "A0A2C9C3L3", "WBGene00020378", "Q18136", "WBGene00006861", "Q09665", "WBGene00006583", "O02159", "WBGene00020378", "G5EDZ8", "WBGene00000288", "Q94288", "WBGene00000287", "Q09980", "WBGene00017394", "O16305", "WBGene00000552", "G5EEG0", "WBGene00000286", "Q18688", "WBGene00000915", "species_71185", "species_216785", "species_73524", "species_113596", "species_29870" ] }, "reaction_10550679": { "compartment": "compartment_70101", "id": "reaction_10550679", "reactome": "R-CEL-5218854", "name": "p-Y420-FYN is phosphorylated on S21", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10550614" ], "products": [ "species_29370", "species_10550562" ], "modifiers": [ [ "species_10550676", "catalyst" ] ], "additional_components": [ "G5EGT9", "WBGene00003007", "A0A1I6CMA1", "WBGene00020678", "Q95PX0", "WBGene00006410", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "G5EGT9", "WBGene00003007", "A0A1I6CMA1", "WBGene00020678", "Q95PX0", "WBGene00006410" ] }, "reaction_10550617": { "compartment": "compartment_876", "id": "reaction_10550617", "reactome": "R-CEL-5218806", "name": "FYN autophosphorylates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10550612" ], "products": [ "species_29370", "species_10550614" ], "modifiers": [ [ "species_10550612", "catalyst" ] ], "additional_components": [ "G5EGT9", "WBGene00003007", "A0A1I6CMA1", "WBGene00020678", "Q95PX0", "WBGene00006410", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "G5EGT9", "WBGene00003007", "A0A1I6CMA1", "WBGene00020678", "Q95PX0", "WBGene00006410", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "G5EGT9", "WBGene00003007", "A0A1I6CMA1", "WBGene00020678", "Q95PX0", "WBGene00006410", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635" ] }, "reaction_10565172": { "compartment": "compartment_70101", "id": "reaction_10565172", "reactome": "R-CEL-8851933", "name": "MET phosphorylates GAB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10565169" ], "products": [ "species_29370", "species_10543879" ], "modifiers": [ [ "species_10565169", "catalyst" ] ], "additional_components": [ "Q9XVQ7", "WBGene00008711", "G5EDJ4", "WBGene00004928", "P29355", "WBGene00004774", "G5EDJ4", "WBGene00004928", "Q9XVQ7", "WBGene00008711", "P29355", "WBGene00004774", "Q9XVQ7", "WBGene00008711", "G5EDJ4", "WBGene00004928", "P29355", "WBGene00004774" ] }, "reaction_10565174": { "compartment": "compartment_70101", "id": "reaction_10565174", "reactome": "R-CEL-8851954", "name": "Phosphorylated GAB1 recruits PI3K to MET", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10506892", "species_10543879" ], "products": [ "species_10543881" ], "modifiers": [], "additional_components": [ "G5EDP9", "WBGene00000001", "Q94125", "WBGene00000090", "G5EDJ4", "WBGene00004928", "Q9XVQ7", "WBGene00008711", "P29355", "WBGene00004774", "G5EDJ4", "WBGene00004928", "Q9XVQ7", "WBGene00008711", "P29355", "WBGene00004774", "G5EDP9", "WBGene00000001", "Q94125", "WBGene00000090" ] }, "reaction_10565177": { "compartment": "compartment_70101", "id": "reaction_10565177", "reactome": "R-CEL-8852019", "name": "MET bound PI3K generates PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10543881", "catalyst" ] ], "additional_components": [ "G5EDJ4", "WBGene00004928", "Q9XVQ7", "WBGene00008711", "P29355", "WBGene00004774", "G5EDP9", "WBGene00000001", "Q94125", "WBGene00000090" ] }, "reaction_10532954": { "compartment": "compartment_876", "id": "reaction_10532954", "reactome": "R-CEL-1306972", "name": "RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10512175", "species_29438" ], "products": [ "species_29420", "species_10511481" ], "modifiers": [ [ "species_10532951", "catalyst" ] ], "additional_components": [ "species_29420", "P22981", "WBGene00002335", "species_29438", "P22981", "WBGene00002335", "P29355", "WBGene00004774", "Q9N5D3", "WBGene00004947" ] }, "reaction_10532961": { "compartment": "compartment_876", "id": "reaction_10532961", "reactome": "R-CEL-1306979", "name": "PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10532958", "catalyst" ] ], "additional_components": [ "G5EDP9", "WBGene00000001", "Q94125", "WBGene00000090" ] }, "reaction_10532945": { "compartment": "compartment_876", "id": "reaction_10532945", "reactome": "R-CEL-1306957", "name": "PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10532942", "catalyst" ] ], "additional_components": [ "Q94125", "WBGene00000090", "G5EDP9", "WBGene00000001", "P29355", "WBGene00004774", "G5EDJ4", "WBGene00004928" ] }, "reaction_10532947": { "compartment": "compartment_70101", "id": "reaction_10532947", "reactome": "R-CEL-1306965", "name": "Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR.", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10506892", "species_10532938" ], "products": [ "species_10532942" ], "modifiers": [], "additional_components": [ "G5EDP9", "WBGene00000001", "Q94125", "WBGene00000090", "P29355", "WBGene00004774", "G5EDJ4", "WBGene00004928", "Q94125", "WBGene00000090", "G5EDP9", "WBGene00000001", "P29355", "WBGene00004774", "G5EDJ4", "WBGene00004928" ] }, "reaction_10532507": { "compartment": "compartment_876", "id": "reaction_10532507", "reactome": "R-CEL-1250462", "name": "PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10532504", "catalyst" ] ], "additional_components": [ "G5EDP9", "WBGene00000001", "Q94125", "WBGene00000090" ] }, "reaction_10572739": { "compartment": "compartment_70101", "id": "reaction_10572739", "reactome": "R-CEL-9652264", "name": "ERBB2 binds TKIs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9652360", "species_10538183" ], "products": [ "species_10572737" ], "modifiers": [], "additional_components": [ "P24348", "WBGene00002299", "O02108", "WBGene00021097", "Q18688", "WBGene00000915", "O02108", "WBGene00021097", "Q18688", "WBGene00000915", "P24348", "WBGene00002299" ] }, "reaction_10538193": { "compartment": "compartment_70101", "id": "reaction_10538193", "reactome": "R-CEL-1918095", "name": "CUL5 mediates ubiquitination of ERBB2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502375", "species_10538183" ], "products": [ "species_10538190" ], "modifiers": [ [ "species_10530998", "catalyst" ] ], "additional_components": [ "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "P24348", "WBGene00002299", "O02108", "WBGene00021097", "Q18688", "WBGene00000915", "P24348", "WBGene00002299", "O02108", "WBGene00021097", "Q18688", "WBGene00000915", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "WBGene00000840" ] }, "reaction_10538188": { "compartment": "compartment_70101", "id": "reaction_10538188", "reactome": "R-CEL-1918092", "name": "CHIP (STUB1) mediates ubiquitination of ERBB2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502375", "species_10538183" ], "products": [ "species_10538185" ], "modifiers": [ [ "species_10530864", "catalyst" ] ], "additional_components": [ "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "P24348", "WBGene00002299", "O02108", "WBGene00021097", "Q18688", "WBGene00000915", "P24348", "WBGene00002299", "O02108", "WBGene00021097", "Q18688", "WBGene00000915", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "WBGene00000500" ] }, "reaction_10512456": { "compartment": "compartment_984", "id": "reaction_10512456", "reactome": "R-CEL-186785", "name": "PDGF-AA clevage by Furin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10512452" ], "products": [ "species_10512392", "species_10512454" ], "modifiers": [ [ "species_10510315", "catalyst" ] ], "additional_components": [ "Q9N413", "WBGene00004249", "Q9N413", "WBGene00004249", "WBGene00004249", "WBGene00002232" ] }, "reaction_10520337": { "compartment": "compartment_70101", "id": "reaction_10520337", "reactome": "R-CEL-382058", "name": "Nck binds to the active PDGF receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10518510", "species_10512404" ], "products": [ "species_10520335" ], "modifiers": [], "additional_components": [ "WBGene00006410", "Q9N413", "WBGene00004249", "G5EGT9", "WBGene00003007", "A0A1I6CMA1", "WBGene00020678", "Q9N413", "WBGene00004249", "G5EGT9", "WBGene00003007", "A0A1I6CMA1", "WBGene00020678", "Q95PX0", "WBGene00006410" ] }, "reaction_10512466": { "compartment": "compartment_70101", "id": "reaction_10512466", "reactome": "R-CEL-186800", "name": "PI3K catalyses the phosphorylation of PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10512444", "catalyst" ] ], "additional_components": [ "Q9N413", "WBGene00004249", "G5EGT9", "WBGene00003007", "A0A1I6CMA1", "WBGene00020678", "G5EDP9", "WBGene00000001", "Q94125", "WBGene00000090" ] }, "reaction_10535202": { "compartment": "compartment_876", "id": "reaction_10535202", "reactome": "R-CEL-1524186", "name": "Phosphorylation of PLCgamma by PDGFR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10512408" ], "products": [ "species_10535197", "species_29370" ], "modifiers": [ [ "species_10512408", "catalyst" ] ], "additional_components": [ "Q9N413", "WBGene00004249", "G5EGT9", "WBGene00003007", "A0A1I6CMA1", "WBGene00020678", "Q22070", "WBGene00004038", "Q22070", "WBGene00004038", "Q9N413", "WBGene00004249", "G5EGT9", "WBGene00003007", "A0A1I6CMA1", "WBGene00020678", "Q9N413", "WBGene00004249", "G5EGT9", "WBGene00003007", "A0A1I6CMA1", "WBGene00020678", "Q22070", "WBGene00004038" ] }, "reaction_10519939": { "compartment": "compartment_70101", "id": "reaction_10519939", "reactome": "R-CEL-380782", "name": "STAT binds to the active receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10519935", "species_10512404" ], "products": [ "species_10519937" ], "modifiers": [], "additional_components": [ "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251", "Q9N413", "WBGene00004249", "G5EGT9", "WBGene00003007", "A0A1I6CMA1", "WBGene00020678", "Q9N413", "WBGene00004249", "G5EGT9", "WBGene00003007", "A0A1I6CMA1", "WBGene00020678", "Q9NAD6", "WBGene00013111", "Q20977", "WBGene00010251" ] }, "reaction_10512484": { "compartment": "compartment_876", "id": "reaction_10512484", "reactome": "R-CEL-186819", "name": "SH2 domain of Src binds to the active receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10512404", "species_10512480" ], "products": [ "species_10512482" ], "modifiers": [], "additional_components": [ "Q9N413", "WBGene00004249", "G5EGT9", "WBGene00003007", "A0A1I6CMA1", "WBGene00020678", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q9N413", "WBGene00004249", "G5EGT9", "WBGene00003007", "A0A1I6CMA1", "WBGene00020678" ] }, "reaction_10512488": { "compartment": "compartment_70101", "id": "reaction_10512488", "reactome": "R-CEL-186826", "name": "GRB2:SOS1 complex binds to the active receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10506878", "species_10512404" ], "products": [ "species_10512486" ], "modifiers": [], "additional_components": [ "P29355", "WBGene00004774", "Q9N5D3", "WBGene00004947", "Q9N413", "WBGene00004249", "G5EGT9", "WBGene00003007", "A0A1I6CMA1", "WBGene00020678", "Q9N413", "WBGene00004249", "G5EGT9", "WBGene00003007", "A0A1I6CMA1", "WBGene00020678", "P29355", "WBGene00004774", "Q9N5D3", "WBGene00004947" ] }, "reaction_10512410": { "compartment": "compartment_876", "id": "reaction_10512410", "reactome": "R-CEL-186765", "name": "PLC-gamma binds to the active receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10512406", "species_10512404" ], "products": [ "species_10512408" ], "modifiers": [], "additional_components": [ "WBGene00004038", "Q9N413", "WBGene00004249", "G5EGT9", "WBGene00003007", "A0A1I6CMA1", "WBGene00020678", "Q9N413", "WBGene00004249", "G5EGT9", "WBGene00003007", "A0A1I6CMA1", "WBGene00020678", "Q22070", "WBGene00004038" ] }, "reaction_10512491": { "compartment": "compartment_70101", "id": "reaction_10512491", "reactome": "R-CEL-186834", "name": "SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10512175", "species_29438" ], "products": [ "species_29420", "species_10511481" ], "modifiers": [ [ "species_10512486", "catalyst" ] ], "additional_components": [ "species_29420", "P22981", "WBGene00002335", "species_29438", "P22981", "WBGene00002335", "Q9N413", "WBGene00004249", "G5EGT9", "WBGene00003007", "A0A1I6CMA1", "WBGene00020678", "P29355", "WBGene00004774", "Q9N5D3", "WBGene00004947" ] }, "reaction_10519901": { "compartment": "compartment_70101", "id": "reaction_10519901", "reactome": "R-CEL-380780", "name": "Activation of Src", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10512482" ], "products": [ "species_10519898", "species_29370" ], "modifiers": [ [ "species_10512482", "catalyst" ] ], "additional_components": [ "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q9N413", "WBGene00004249", "G5EGT9", "WBGene00003007", "A0A1I6CMA1", "WBGene00020678", "Q9N413", "WBGene00004249", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "G5EGT9", "WBGene00003007", "A0A1I6CMA1", "WBGene00020678", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q9N413", "WBGene00004249", "G5EGT9", "WBGene00003007", "A0A1I6CMA1", "WBGene00020678" ] }, "reaction_10512446": { "compartment": "compartment_70101", "id": "reaction_10512446", "reactome": "R-CEL-186780", "name": "PI3-kinase binds to the active receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10506892", "species_10512404" ], "products": [ "species_10512444" ], "modifiers": [], "additional_components": [ "G5EDP9", "WBGene00000001", "Q94125", "WBGene00000090", "Q9N413", "WBGene00004249", "G5EGT9", "WBGene00003007", "A0A1I6CMA1", "WBGene00020678", "Q9N413", "WBGene00004249", "G5EGT9", "WBGene00003007", "A0A1I6CMA1", "WBGene00020678", "G5EDP9", "WBGene00000001", "Q94125", "WBGene00000090" ] }, "reaction_10535199": { "compartment": "compartment_876", "id": "reaction_10535199", "reactome": "R-CEL-1524182", "name": "Activated PLC gamma dissociates from the PDGF receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10535197" ], "products": [ "species_10512404", "species_10515233" ], "modifiers": [], "additional_components": [ "Q22070", "WBGene00004038", "Q9N413", "WBGene00004249", "G5EGT9", "WBGene00003007", "A0A1I6CMA1", "WBGene00020678", "Q9N413", "WBGene00004249", "G5EGT9", "WBGene00003007", "A0A1I6CMA1", "WBGene00020678", "WBGene00004038" ] }, "reaction_10520319": { "compartment": "compartment_70101", "id": "reaction_10520319", "reactome": "R-CEL-382056", "name": "Crk binds to the active PDGF receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10520269", "species_10512404" ], "products": [ "species_10520271" ], "modifiers": [], "additional_components": [ "Q9NHC3", "WBGene00000416", "Q95XA9", "WBGene00021238", "Q9N413", "WBGene00004249", "G5EGT9", "WBGene00003007", "A0A1I6CMA1", "WBGene00020678", "Q9N413", "WBGene00004249", "G5EGT9", "WBGene00003007", "A0A1I6CMA1", "WBGene00020678", "Q9NHC3", "WBGene00000416", "Q95XA9", "WBGene00021238" ] }, "reaction_10573065": { "compartment": "compartment_876", "id": "reaction_10573065", "reactome": "R-CEL-9674093", "name": "PDGFRs bind type I TKI", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10520554", "species_9674075" ], "products": [ "species_10520559" ], "modifiers": [], "additional_components": [ "Q9N413", "WBGene00004249", "A0A1I6CMA1", "WBGene00020678", "G5EGT9", "WBGene00003007", "Q9N413", "WBGene00004249", "A0A1I6CMA1", "WBGene00020678", "G5EGT9", "WBGene00003007" ] }, "reaction_10573067": { "compartment": "compartment_876", "id": "reaction_10573067", "reactome": "R-CEL-9674095", "name": "PDGFRs bind type II TKI", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9674079", "species_10512424" ], "products": [ "species_10512436" ], "modifiers": [], "additional_components": [ "A0A1I6CMA1", "WBGene00020678", "G5EGT9", "WBGene00003007", "A0A1I6CMA1", "WBGene00020678", "G5EGT9", "WBGene00003007" ] }, "reaction_10520333": { "compartment": "compartment_984", "id": "reaction_10520333", "reactome": "R-CEL-382057", "name": "Release of novel PDGFs as latent factors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10520321" ], "products": [ "species_10520331" ], "modifiers": [], "additional_components": [ "Q9N413", "WBGene00004249", "Q9N413", "WBGene00004249" ] }, "reaction_10566190": { "compartment": "compartment_984", "id": "reaction_10566190", "reactome": "R-CEL-8865275", "name": "PDGF-BB clevage by Furin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10520297" ], "products": [ "species_10512398", "species_10566186" ], "modifiers": [ [ "species_10510315", "catalyst" ] ], "additional_components": [ "Q9N413", "WBGene00004249", "Q9N413", "WBGene00004249", "WBGene00004249", "WBGene00002232" ] }, "reaction_10512463": { "compartment": "compartment_70101", "id": "reaction_10512463", "reactome": "R-CEL-186786", "name": "Autophosphorylation of PDGF beta receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10512458", "species_113592" ], "products": [ "species_10512460", "species_29370" ], "modifiers": [ [ "species_10512458", "catalyst" ] ], "additional_components": [ "A0A1I6CMA1", "WBGene00020678", "G5EGT9", "WBGene00003007", "Q9N413", "WBGene00004249", "G5EGT9", "WBGene00003007", "A0A1I6CMA1", "WBGene00020678", "Q9N413", "WBGene00004249", "A0A1I6CMA1", "WBGene00020678", "G5EGT9", "WBGene00003007", "Q9N413", "WBGene00004249" ] }, "reaction_10566192": { "compartment": "compartment_984", "id": "reaction_10566192", "reactome": "R-CEL-8865276", "name": "PDGF-AB clevage by Furin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10520299" ], "products": [ "species_10566186", "species_10512454", "species_10512400" ], "modifiers": [ [ "species_10510315", "catalyst" ] ], "additional_components": [ "Q9N413", "WBGene00004249", "WBGene00004249", "WBGene00004249", "Q9N413", "WBGene00004249", "WBGene00002232" ] }, "reaction_10520561": { "compartment": "compartment_70101", "id": "reaction_10520561", "reactome": "R-CEL-389083", "name": "Autophosphorylation of PDGF alpha receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10520554", "species_113592" ], "products": [ "species_10520556", "species_29370" ], "modifiers": [ [ "species_10520554", "catalyst" ], [ "species_10520559", "inhibitor" ] ], "additional_components": [ "Q9N413", "WBGene00004249", "A0A1I6CMA1", "WBGene00020678", "G5EGT9", "WBGene00003007", "Q9N413", "WBGene00004249", "G5EGT9", "WBGene00003007", "A0A1I6CMA1", "WBGene00020678", "Q9N413", "WBGene00004249", "A0A1I6CMA1", "WBGene00020678", "G5EGT9", "WBGene00003007", "Q9N413", "WBGene00004249", "A0A1I6CMA1", "WBGene00020678", "G5EGT9", "WBGene00003007" ] }, "reaction_10520311": { "compartment": "compartment_20699", "id": "reaction_10520311", "reactome": "R-CEL-382053", "name": "Translocation of PDGF from ER to Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10520293" ], "products": [ "species_10520309" ], "modifiers": [], "additional_components": [ "Q9N413", "WBGene00004249", "Q9N413", "WBGene00004249" ] }, "reaction_10512440": { "compartment": "compartment_876", "id": "reaction_10512440", "reactome": "R-CEL-186773", "name": "PDGF dimer binds two receptors simultaneously", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10512424", "species_10512402" ], "products": [ "species_10512434" ], "modifiers": [ [ "species_10512438", "inhibitor" ], [ "species_10512436", "inhibitor" ] ], "additional_components": [ "A0A1I6CMA1", "WBGene00020678", "G5EGT9", "WBGene00003007", "Q9N413", "WBGene00004249", "A0A1I6CMA1", "WBGene00020678", "G5EGT9", "WBGene00003007", "Q9N413", "WBGene00004249", "A0A1I6CMA1", "WBGene00020678", "G5EGT9", "WBGene00003007", "A0A1I6CMA1", "WBGene00020678", "G5EGT9", "WBGene00003007" ] }, "reaction_10520571": { "compartment": "compartment_70101", "id": "reaction_10520571", "reactome": "R-CEL-389086", "name": "Autophosphorylation of PDGF alpha/beta receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10520566" ], "products": [ "species_29370", "species_10520568" ], "modifiers": [ [ "species_10520566", "catalyst" ] ], "additional_components": [ "Q9N413", "WBGene00004249", "A0A1I6CMA1", "WBGene00020678", "G5EGT9", "WBGene00003007", "Q9N413", "WBGene00004249", "G5EGT9", "WBGene00003007", "A0A1I6CMA1", "WBGene00020678", "Q9N413", "WBGene00004249", "A0A1I6CMA1", "WBGene00020678", "G5EGT9", "WBGene00003007" ] }, "reaction_10520317": { "compartment": "compartment_984", "id": "reaction_10520317", "reactome": "R-CEL-382054", "name": "PDGF binds to extracellular matrix proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10512396", "species_10520313" ], "products": [ "species_10520315" ], "modifiers": [], "additional_components": [ "WBGene00004249", "Q9N4U2", "WBGene00000647", "O76368", "WBGene00000674", "Q09457", "WBGene00000251", "P17140", "WBGene00002280", "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689", "CHEBI:18137", "CHEBI:17421", "Q9N4U2", "WBGene00000647", "O76368", "WBGene00000674", "Q09457", "WBGene00000251", "P17140", "WBGene00002280", "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689", "CHEBI:18137", "CHEBI:17421", "Q9N413", "WBGene00004249" ] }, "reaction_10533137": { "compartment": "compartment_876", "id": "reaction_10533137", "reactome": "R-CEL-1433423", "name": "PTP-RO interacts with p-c-Kit complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10533133", "species_10516216" ], "products": [ "species_10533135" ], "modifiers": [], "additional_components": [ "G5EC69", "WBGene00011755", "Q20019", "WBGene00011755", "Q21522", "WBGene00011755", "A0A1I6CMA1", "WBGene00020678", "G5EGT9", "WBGene00003007", "A0A1I6CMA1", "WBGene00020678", "G5EGT9", "WBGene00003007", "G5EC69", "WBGene00011755", "Q20019", "WBGene00011755", "Q21522", "WBGene00011755" ] }, "reaction_10573104": { "compartment": "compartment_876", "id": "reaction_10573104", "reactome": "R-CEL-9681375", "name": "KIT binds ripretinib", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10516216", "species_9674322" ], "products": [ "species_10573102" ], "modifiers": [], "additional_components": [ "A0A1I6CMA1", "WBGene00020678", "G5EGT9", "WBGene00003007", "A0A1I6CMA1", "WBGene00020678", "G5EGT9", "WBGene00003007" ] }, "reaction_10533140": { "compartment": "compartment_876", "id": "reaction_10533140", "reactome": "R-CEL-1433471", "name": "Activation of RAS by p-KIT bound SOS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10512175", "species_29438" ], "products": [ "species_29420", "species_10511481" ], "modifiers": [ [ "species_10516244", "catalyst" ] ], "additional_components": [ "species_29420", "P22981", "WBGene00002335", "species_29438", "P22981", "WBGene00002335", "A0A1I6CMA1", "WBGene00020678", "G5EGT9", "WBGene00003007", "P29355", "WBGene00004774", "Q9N5D3", "WBGene00004947" ] }, "reaction_10533155": { "compartment": "compartment_876", "id": "reaction_10533155", "reactome": "R-CEL-1433508", "name": "PKC alpha interacts with and phosphorylates KIT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10516216", "species_10509044" ], "products": [ "species_29370", "species_10533152" ], "modifiers": [ [ "species_10509044", "catalyst" ] ], "additional_components": [ "A0A1I6CMA1", "WBGene00020678", "G5EGT9", "WBGene00003007", "WBGene00004033", "P90980", "WBGene00004033", "A0A1I6CMA1", "WBGene00020678", "G5EGT9", "WBGene00003007", "WBGene00004033" ] }, "reaction_10516248": { "compartment": "compartment_876", "id": "reaction_10516248", "reactome": "R-CEL-205244", "name": "Recruitment of CBL to KIT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10512267", "species_10516244" ], "products": [ "species_10516246" ], "modifiers": [], "additional_components": [ "WBGene00004829", "A0A1I6CMA1", "WBGene00020678", "G5EGT9", "WBGene00003007", "P29355", "WBGene00004774", "Q9N5D3", "WBGene00004947", "A0A1I6CMA1", "WBGene00020678", "G5EGT9", "WBGene00003007", "P29355", "WBGene00004774", "Q9N5D3", "WBGene00004947", "Q19019", "WBGene00004829" ] }, "reaction_10533180": { "compartment": "compartment_876", "id": "reaction_10533180", "reactome": "R-CEL-1433514", "name": "Synthesis of PIP3 from PIP2 by PI3K", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10533177", "catalyst" ] ], "additional_components": [ "A0A1I6CMA1", "WBGene00020678", "G5EGT9", "WBGene00003007", "Q9N3S5", "WBGene00021635", "G5EE56", "WBGene00005077", "P29355", "WBGene00004774", "G5EDJ4", "WBGene00004928", "G5EDP9", "WBGene00000001", "Q94125", "WBGene00000090" ] }, "reaction_10533119": { "compartment": "compartment_70101", "id": "reaction_10533119", "reactome": "R-CEL-1433415", "name": "Activation of RAC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10520575", "species_29438" ], "products": [ "species_29420", "species_10509457" ], "modifiers": [ [ "species_10533116", "catalyst" ] ], "additional_components": [ "species_29420", "Q03206", "ced-10", "species_29438", "Q03206", "ced-10", "Q45FX5", "WBGene00006887", "species_179838" ] }, "reaction_10573054": { "compartment": "compartment_876", "id": "reaction_10573054", "reactome": "R-CEL-9669854", "name": "KIT binds type II TKIs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9669722", "species_10516216" ], "products": [ "species_10573052" ], "modifiers": [], "additional_components": [ "A0A1I6CMA1", "WBGene00020678", "G5EGT9", "WBGene00003007", "A0A1I6CMA1", "WBGene00020678", "G5EGT9", "WBGene00003007" ] }, "reaction_10506848": { "compartment": "compartment_17940", "id": "reaction_10506848", "reactome": "R-CEL-74723", "name": "Endosome acidification", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106" ], "products": [ "species_74722" ], "modifiers": [ [ "species_10506845", "catalyst" ] ], "additional_components": [ "G5EGP4", "WBGene00006915", "P30628", "WBGene00006768", "B2MZD0", "WBGene00006916", "G5EEK9", "WBGene00006914", "C0HLB3", "WBGene00006911", "C0HLB4", "WBGene00006912", "G5EDB8", "WBGene00006913", "Q95YD5", "WBGene00016258", "Q20591", "WBGene00009882", "Q9XXU9", "WBGene00006920", "Q22494", "WBGene00020507", "Q23680", "WBGene00006918", "P34462", "WBGene00010130", "Q9XW92", "WBGene00013025", "Q19626", "WBGene00006921", "Q9N5A0", "WBGene00004959", "Q95X44", "WBGene00006917", "P91303", "WBGene00006919", "Q9TYW1", "WBGene00021952" ] }, "reaction_10506866": { "compartment": "compartment_876", "id": "reaction_10506866", "reactome": "R-CEL-74734", "name": "Re-integration of insulin receptor into plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10506864" ], "products": [ "species_10506690" ], "modifiers": [], "additional_components": [ "Q968Y9", "WBGene00000898", "Q968Y9", "WBGene00000898" ] }, "reaction_10551244": { "compartment": "compartment_171062", "id": "reaction_10551244", "reactome": "R-CEL-5252133", "name": "ATP6AP1 binds V-ATPase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10506843", "species_10506838" ], "products": [ "species_10506845" ], "modifiers": [], "additional_components": [ "WBGene00021952", "G5EGP4", "WBGene00006915", "P30628", "WBGene00006768", "B2MZD0", "WBGene00006916", "G5EEK9", "WBGene00006914", "C0HLB3", "WBGene00006911", "C0HLB4", "WBGene00006912", "G5EDB8", "WBGene00006913", "Q95YD5", "WBGene00016258", "Q20591", "WBGene00009882", "Q9XXU9", "WBGene00006920", "Q22494", "WBGene00020507", "Q23680", "WBGene00006918", "P34462", "WBGene00010130", "Q9XW92", "WBGene00013025", "Q19626", "WBGene00006921", "Q9N5A0", "WBGene00004959", "Q95X44", "WBGene00006917", "P91303", "WBGene00006919", "G5EGP4", "WBGene00006915", "P30628", "WBGene00006768", "B2MZD0", "WBGene00006916", "G5EEK9", "WBGene00006914", "C0HLB3", "WBGene00006911", "C0HLB4", "WBGene00006912", "G5EDB8", "WBGene00006913", "Q95YD5", "WBGene00016258", "Q20591", "WBGene00009882", "Q9XXU9", "WBGene00006920", "Q22494", "WBGene00020507", "Q23680", "WBGene00006918", "P34462", "WBGene00010130", "Q9XW92", "WBGene00013025", "Q19626", "WBGene00006921", "Q9N5A0", "WBGene00004959", "Q95X44", "WBGene00006917", "P91303", "WBGene00006919", "Q9TYW1", "WBGene00021952" ] }, "reaction_10555984": { "compartment": "compartment_70101", "id": "reaction_10555984", "reactome": "R-CEL-5687107", "name": "MAPK4,6 translocate to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10555976" ], "products": [ "species_10555982" ], "modifiers": [], "additional_components": [ "P39745", "WBGene00003401", "P39745", "WBGene00003401" ] }, "reaction_10555986": { "compartment": "compartment_7660", "id": "reaction_10555986", "reactome": "R-CEL-5687109", "name": "MAPK4,6 translocate to the cytoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10555982" ], "products": [ "species_10555976" ], "modifiers": [ [ "species_10511186", "catalyst" ] ], "additional_components": [ "P39745", "WBGene00003401", "P39745", "WBGene00003401", "WBGene00002078" ] }, "reaction_10520692": { "compartment": "compartment_70101", "id": "reaction_10520692", "reactome": "R-CEL-389788", "name": "Activation of PAKs by RAC1 and CDC42", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10520686", "species_10520664" ], "products": [ "species_10520690", "species_10520688" ], "modifiers": [], "additional_components": [ "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "species_29438", "Q03206", "ced-10", "Q05062", "WBGene00000390", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "species_29438", "Q03206", "ced-10", "Q05062", "WBGene00000390", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911" ] }, "reaction_10555989": { "compartment": "compartment_70101", "id": "reaction_10555989", "reactome": "R-CEL-5687112", "name": "MAPK6 is degraded by the 26S proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10555953" ], "products": [ "species_10502375" ], "modifiers": [ [ "species_10502572", "catalyst" ] ], "additional_components": [ "WBGene00003401", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "P91477", "WBGene00003950", "Q95PZ7", "WBGene00013435", "Q18115", "WBGene00004459", "O62102", "WBGene00003948", "O17071", "WBGene00004504", "Q10920", "WBGene00016623", "P34286", "WBGene00003952", "Q9XTT9", "WBGene00004506", "Q23449", "WBGene00004468", "Q95005", "WBGene00003925", "P46502", "WBGene00004503", "O61792", "WBGene00004464", "O17586", "WBGene00003922", "O76371", "WBGene00004505", "Q20585", "WBGene00004463", "Q95008", "WBGene00003926", "Q18787", "WBGene00004501", "Q20058", "WBGene00009445", "Q9N599", "WBGene00003924", "O16368", "WBGene00004502", "O61742", "WBGene00004466", "Q09583", "WBGene00003928", "Q966I8", "WBGene00003947", "Q04908", "WBGene00004460", "Q9XUV0", "WBGene00003951", "Q27488", "WBGene00003923", "Q9GZH5", "WBGene00004458", "O44156", "WBGene00003927", "Q22253", "WBGene00004465", "O76577", "WBGene00004467", "P90868", "WBGene00003953", "Q19324", "WBGene00004461", "Q17971", "WBGene00007588", "Q23237", "WBGene00003949", "Q20938", "WBGene00004462" ] }, "reaction_10556932": { "compartment": "compartment_7660", "id": "reaction_10556932", "reactome": "R-CEL-5692749", "name": "CDC14A,B bind MAPK6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10556926", "species_10556924" ], "products": [ "species_10556930" ], "modifiers": [], "additional_components": [ "WBGene00000383", "WBGene00003401", "P39745", "WBGene00003401", "P81299", "WBGene00000383" ] }, "reaction_10556937": { "compartment": "compartment_7660", "id": "reaction_10556937", "reactome": "R-CEL-5692754", "name": "CDC14A,B dephosphorylate p-3S,T MAPK6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10556930" ], "products": [ "species_113550", "species_10556934" ], "modifiers": [ [ "species_10556930", "catalyst" ] ], "additional_components": [ "P39745", "WBGene00003401", "P81299", "WBGene00000383", "P39745", "WBGene00003401", "P81299", "WBGene00000383", "P39745", "WBGene00003401", "P81299", "WBGene00000383" ] }, "reaction_10555993": { "compartment": "compartment_70101", "id": "reaction_10555993", "reactome": "R-CEL-5687126", "name": "p-S215 FOXO3 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10555974" ], "products": [ "species_10555970" ], "modifiers": [], "additional_components": [ "WBGene00000912", "WBGene00000912" ] }, "reaction_10555963": { "compartment": "compartment_70101", "id": "reaction_10555963", "reactome": "R-CEL-5687086", "name": "PAK1,2,3 phosphorylates MAPK6,4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10555955" ], "products": [ "species_29370", "species_10555958" ], "modifiers": [ [ "species_10521284", "catalyst" ] ], "additional_components": [ "WBGene00003401", "WBGene00003401", "Q17850", "WBGene00003911", "G5EGQ3", "WBGene00003144" ] }, "reaction_10556940": { "compartment": "compartment_7660", "id": "reaction_10556940", "reactome": "R-CEL-5692755", "name": "CDK1 phosphorylates MAPK6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10555980" ], "products": [ "species_113582", "species_10556924" ], "modifiers": [ [ "species_10511154", "catalyst" ] ], "additional_components": [ "WBGene00003401", "WBGene00003401", "WBGene00000405" ] }, "reaction_10555185": { "compartment": "compartment_876", "id": "reaction_10555185", "reactome": "R-CEL-5675194", "name": "Activated MAPK phosphorylates RAF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10554998" ], "products": [ "species_10555183", "species_29370" ], "modifiers": [ [ "species_10555165", "catalyst" ] ], "additional_components": [ "WBGene00003030", "WBGene00003030", "P39745", "WBGene00003401" ] }, "reaction_10555193": { "compartment": "compartment_876", "id": "reaction_10555193", "reactome": "R-CEL-5675198", "name": "Activated MAPKs phosphorylate BRAF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10555000" ], "products": [ "species_29370", "species_10555191" ], "modifiers": [ [ "species_10555165", "catalyst" ] ], "additional_components": [ "WBGene00003030", "WBGene00003030", "P39745", "WBGene00003401" ] }, "reaction_10555176": { "compartment": "compartment_70101", "id": "reaction_10555176", "reactome": "R-CEL-5674496", "name": "Activated MAPKs phosphorylate MAP2K1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10555059" ], "products": [ "species_29370", "species_10555173" ], "modifiers": [ [ "species_10555165", "catalyst" ] ], "additional_components": [ "Q10664", "WBGene00003186", "Q10664", "WBGene00003186", "P39745", "WBGene00003401" ] }, "reaction_10555140": { "compartment": "compartment_20699", "id": "reaction_10555140", "reactome": "R-CEL-5674140", "name": "PAQR3 binds inactive RAFs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10554946", "species_10555136" ], "products": [ "species_10555138" ], "modifiers": [], "additional_components": [ "WBGene00003030", "WBGene00013457", "Q9U1V1", "WBGene00013457", "Q07292", "WBGene00003030" ] }, "reaction_10555236": { "compartment": "compartment_876", "id": "reaction_10555236", "reactome": "R-CEL-5675431", "name": "PP2A dephosphorylates RAF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10555230", "species_29356" ], "products": [ "species_29372", "species_10555234" ], "modifiers": [ [ "species_10513555", "catalyst" ], [ "species_10555183", "catalyst" ] ], "additional_components": [ "Q07292", "WBGene00003030", "species_29438", "P22981", "WBGene00002335", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "Q07292", "WBGene00003030", "species_29438", "P22981", "WBGene00002335", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "WBGene00003030" ] }, "reaction_10555110": { "compartment": "compartment_876", "id": "reaction_10555110", "reactome": "R-CEL-5674022", "name": "BRAP autoubiquitinates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10555100", "species_10502375" ], "products": [ "species_10555107" ], "modifiers": [ [ "species_10555100", "catalyst" ] ], "additional_components": [ "species_29438", "P22981", "WBGene00002335", "Q95QN6", "WBGene00017144", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "Q95QN6", "WBGene00017144", "species_29438", "P22981", "WBGene00002335", "species_29438", "P22981", "WBGene00002335", "Q95QN6", "WBGene00017144" ] }, "reaction_10566377": { "compartment": "compartment_70101", "id": "reaction_10566377", "reactome": "R-CEL-8867654", "name": "PTPN3 binds p-T183,Y185 MAPK12", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10525306", "species_10566373" ], "products": [ "species_10566375" ], "modifiers": [], "additional_components": [ "Q17446", "WBGene00004055", "Q8MXI4", "WBGene00004056", "WBGene00004213", "P28191", "WBGene00004213", "Q17446", "WBGene00004055", "Q8MXI4", "WBGene00004056" ] }, "reaction_10566488": { "compartment": "compartment_70101", "id": "reaction_10566488", "reactome": "R-CEL-8868118", "name": "MAPK12 phosphorylates PTPN3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10566375" ], "products": [ "species_29370", "species_10566485" ], "modifiers": [ [ "species_10566375", "catalyst" ] ], "additional_components": [ "P28191", "WBGene00004213", "Q17446", "WBGene00004055", "Q8MXI4", "WBGene00004056", "P28191", "WBGene00004213", "Q17446", "WBGene00004055", "Q8MXI4", "WBGene00004056", "P28191", "WBGene00004213", "Q17446", "WBGene00004055", "Q8MXI4", "WBGene00004056" ] }, "reaction_10555226": { "compartment": "compartment_876", "id": "reaction_10555226", "reactome": "R-CEL-5675417", "name": "PEBP1 binds activated RAF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10555049", "species_10555044" ], "products": [ "species_10555051" ], "modifiers": [], "additional_components": [ "WBGene00018218", "Q07292", "WBGene00003030", "species_29438", "P22981", "WBGene00002335", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "Q07292", "WBGene00003030", "species_29438", "P22981", "WBGene00002335", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "O16264", "WBGene00018218" ] }, "reaction_10555245": { "compartment": "compartment_876", "id": "reaction_10555245", "reactome": "R-CEL-5675433", "name": "PP5 dephosphorylates RAF1 S338", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10555044" ], "products": [ "species_10555230", "species_29372" ], "modifiers": [ [ "species_10555242", "catalyst" ] ], "additional_components": [ "Q07292", "WBGene00003030", "species_29438", "P22981", "WBGene00002335", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "Q07292", "WBGene00003030", "species_29438", "P22981", "WBGene00002335", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "WBGene00012665" ] }, "reaction_10566380": { "compartment": "compartment_70101", "id": "reaction_10566380", "reactome": "R-CEL-8867658", "name": "PTPN3 dephosphorylates MAPK12", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10566375" ], "products": [ "species_29372", "species_10566373", "species_10526147" ], "modifiers": [ [ "species_10566375", "catalyst" ] ], "additional_components": [ "P28191", "WBGene00004213", "Q17446", "WBGene00004055", "Q8MXI4", "WBGene00004056", "WBGene00004213", "Q8MXI4", "WBGene00004056", "Q17446", "WBGene00004055", "P28191", "WBGene00004213", "Q17446", "WBGene00004055", "Q8MXI4", "WBGene00004056" ] }, "reaction_10555102": { "compartment": "compartment_876", "id": "reaction_10555102", "reactome": "R-CEL-5674018", "name": "BRAP binds RAS:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10555098", "species_10511481" ], "products": [ "species_10555100" ], "modifiers": [], "additional_components": [ "WBGene00017144", "species_29438", "P22981", "WBGene00002335", "species_29438", "P22981", "WBGene00002335", "Q95QN6", "WBGene00017144" ] }, "reaction_10572703": { "compartment": "compartment_876", "id": "reaction_10572703", "reactome": "R-CEL-9649736", "name": "RAS intrinsic GTPase activity hydrolyzes GTP to GDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10511481" ], "products": [ "species_10512175" ], "modifiers": [ [ "species_10511481", "catalyst" ] ], "additional_components": [ "species_29438", "P22981", "WBGene00002335", "species_29420", "P22981", "WBGene00002335", "species_29438", "P22981", "WBGene00002335" ] }, "reaction_10572700": { "compartment": "compartment_876", "id": "reaction_10572700", "reactome": "R-CEL-9649735", "name": "Intrinsic nucleotide exchange on RAS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10512175", "species_29438" ], "products": [ "species_29420", "species_10511481" ], "modifiers": [], "additional_components": [ "species_29420", "P22981", "WBGene00002335", "species_29438", "P22981", "WBGene00002335" ] }, "reaction_10572741": { "compartment": "compartment_876", "id": "reaction_10572741", "reactome": "R-CEL-9653108", "name": "Raf dimer inhibitors bind RAF heterodimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9657579", "species_10554994" ], "products": [ "species_10555084" ], "modifiers": [], "additional_components": [ "Q07292", "WBGene00003030", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "species_29438", "P22981", "WBGene00002335", "Q07292", "WBGene00003030", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "species_29438", "P22981", "WBGene00002335" ] }, "reaction_10554964": { "compartment": "compartment_70101", "id": "reaction_10554964", "reactome": "R-CEL-5672960", "name": "YWHAB dimer dissociates from dephosphorylated RAF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10554962" ], "products": [ "species_10507067", "species_10554906" ], "modifiers": [], "additional_components": [ "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "Q07292", "WBGene00003030", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "WBGene00003030" ] }, "reaction_10554996": { "compartment": "compartment_876", "id": "reaction_10554996", "reactome": "R-CEL-5672966", "name": "RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10554906", "species_10554935" ], "products": [ "species_10554994" ], "modifiers": [], "additional_components": [ "WBGene00003030", "Q07292", "WBGene00003030", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "species_29438", "P22981", "WBGene00002335", "Q07292", "WBGene00003030", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "species_29438", "P22981", "WBGene00002335" ] }, "reaction_10554967": { "compartment": "compartment_70101", "id": "reaction_10554967", "reactome": "R-CEL-5672961", "name": "PP2A dephosphorylates inactive RAFs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10554954" ], "products": [ "species_29372", "species_10554962" ], "modifiers": [ [ "species_10513555", "catalyst" ] ], "additional_components": [ "Q07292", "WBGene00003030", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "Q07292", "WBGene00003030" ] }, "reaction_10572954": { "compartment": "compartment_876", "id": "reaction_10572954", "reactome": "R-CEL-9658445", "name": "MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10554954" ], "products": [ "species_29372", "species_10554962" ], "modifiers": [ [ "species_10572951", "catalyst" ] ], "additional_components": [ "Q07292", "WBGene00003030", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "Q07292", "WBGene00003030", "Q27497", "WBGene00001747", "P48727", "WBGene00001748", "Q22875", "WBGene00004929", "G5EGA7", "WBGene00004311", "species_29438" ] }, "reaction_10554956": { "compartment": "compartment_70101", "id": "reaction_10554956", "reactome": "R-CEL-5672951", "name": "Inactive RAFs bind YWHAB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10507067", "species_10554946" ], "products": [ "species_10554954" ], "modifiers": [], "additional_components": [ "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "WBGene00003030", "Q07292", "WBGene00003030", "P41932", "WBGene00003920", "Q20655", "WBGene00001502" ] }, "reaction_10554942": { "compartment": "compartment_876", "id": "reaction_10554942", "reactome": "R-CEL-5672950", "name": "\"Activator\" RAF:YWHAB dimer binds RAS:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10511481", "species_10554933" ], "products": [ "species_10554935" ], "modifiers": [ [ "species_10554940", "catalyst" ] ], "additional_components": [ "species_29438", "P22981", "WBGene00002335", "Q07292", "WBGene00003030", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "Q07292", "WBGene00003030", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "species_29438", "P22981", "WBGene00002335", "WBGene00004014" ] }, "reaction_10572966": { "compartment": "compartment_876", "id": "reaction_10572966", "reactome": "R-CEL-9660557", "name": "RAS:GTP binds RAL GDS proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10511486", "species_10572962" ], "products": [ "species_10572964" ], "modifiers": [], "additional_components": [ "WBGene00017891", "P22981", "WBGene00002335", "species_29438", "P22981", "WBGene00002335", "species_29438", "Q19852", "WBGene00017891" ] }, "reaction_10572576": { "compartment": "compartment_12045", "id": "reaction_10572576", "reactome": "R-CEL-9647977", "name": "ICMT methylates S-Farn RAS proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10572567", "species_71284" ], "products": [ "species_10572572", "species_71285" ], "modifiers": [ [ "species_10558332", "catalyst" ], [ "species_10572574", "inhibitor" ] ], "additional_components": [ "WBGene00002335", "WBGene00002335", "species_216785", "P91402", "WBGene00019710", "species_216785", "P91402", "WBGene00019710" ] }, "reaction_10572896": { "compartment": "compartment_876", "id": "reaction_10572896", "reactome": "R-CEL-9654521", "name": "Calmodulin dissociates KRAS4B from the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10549080" ], "products": [ "species_10572894" ], "modifiers": [], "additional_components": [ "species_74016", "Q11083", "WBGene00020378", "P04630", "WBGene00000285", "G5EF37", "WBGene00003934", "A0A2C9C3L3", "WBGene00020378", "Q18136", "WBGene00006861", "Q09665", "WBGene00006583", "O02159", "WBGene00020378", "G5EDZ8", "WBGene00000288", "Q94288", "WBGene00000287", "Q09980", "WBGene00017394", "O16305", "WBGene00000552", "G5EEG0", "WBGene00000286", "P22981", "WBGene00002335", "species_74016", "Q11083", "WBGene00020378", "P04630", "WBGene00000285", "G5EF37", "WBGene00003934", "A0A2C9C3L3", "WBGene00020378", "Q18136", "WBGene00006861", "Q09665", "WBGene00006583", "O02159", "WBGene00020378", "G5EDZ8", "WBGene00000288", "Q94288", "WBGene00000287", "Q09980", "WBGene00017394", "O16305", "WBGene00000552", "G5EEG0", "WBGene00000286", "P22981", "WBGene00002335" ] }, "reaction_10572610": { "compartment": "compartment_20699", "id": "reaction_10572610", "reactome": "R-CEL-9647982", "name": "S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10572572", "species_200993" ], "products": [ "species_76194", "species_10572592" ], "modifiers": [ [ "species_10572607", "catalyst" ] ], "additional_components": [ "WBGene00002335", "WBGene00002335", "Q9U204", "WBGene00013323", "Q9XWD7", "WBGene00012948" ] }, "reaction_10572612": { "compartment": "compartment_70101", "id": "reaction_10572612", "reactome": "R-CEL-9647987", "name": "FNTB inhibitors bind FNTA:FNTB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9653479", "species_10544771" ], "products": [ "species_10572587" ], "modifiers": [], "additional_components": [ "Q19752", "WBGene00006465", "O44501", "WBGene00019823", "Q19752", "WBGene00006465", "O44501", "WBGene00019823" ] }, "reaction_10572679": { "compartment": "compartment_12045", "id": "reaction_10572679", "reactome": "R-CEL-9647999", "name": "RCE1 cleaves S-Farn proRAS proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10572583" ], "products": [ "species_10572567" ], "modifiers": [ [ "species_10572676", "catalyst" ] ], "additional_components": [ "WBGene00002335", "WBGene00002335", "WBGene00001406" ] }, "reaction_10572902": { "compartment": "compartment_70101", "id": "reaction_10572902", "reactome": "R-CEL-9654523", "name": "ARL2:GTP bind PDE6D on KRAS4B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10572898", "species_10550993" ], "products": [ "species_10572900" ], "modifiers": [], "additional_components": [ "Q18268", "WBGene00003966", "species_74016", "Q11083", "WBGene00020378", "P04630", "WBGene00000285", "G5EF37", "WBGene00003934", "A0A2C9C3L3", "WBGene00020378", "Q18136", "WBGene00006861", "Q09665", "WBGene00006583", "O02159", "WBGene00020378", "G5EDZ8", "WBGene00000288", "Q94288", "WBGene00000287", "Q09980", "WBGene00017394", "O16305", "WBGene00000552", "G5EEG0", "WBGene00000286", "P22981", "WBGene00002335", "species_29438", "Q19705", "WBGene00001358", "species_29438", "Q19705", "WBGene00001358", "Q18268", "WBGene00003966", "species_74016", "Q11083", "WBGene00020378", "P04630", "WBGene00000285", "G5EF37", "WBGene00003934", "A0A2C9C3L3", "WBGene00020378", "Q18136", "WBGene00006861", "Q09665", "WBGene00006583", "O02159", "WBGene00020378", "G5EDZ8", "WBGene00000288", "Q94288", "WBGene00000287", "Q09980", "WBGene00017394", "O16305", "WBGene00000552", "G5EEG0", "WBGene00000286", "P22981", "WBGene00002335" ] }, "reaction_10572906": { "compartment": "compartment_70101", "id": "reaction_10572906", "reactome": "R-CEL-9654525", "name": "PDE6D binds S-Farn-Me KRAS4B:CALM:4 Ca2+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10572894", "species_10553585" ], "products": [ "species_10572898" ], "modifiers": [ [ "species_10572904", "inhibitor" ] ], "additional_components": [ "species_74016", "Q11083", "WBGene00020378", "P04630", "WBGene00000285", "G5EF37", "WBGene00003934", "A0A2C9C3L3", "WBGene00020378", "Q18136", "WBGene00006861", "Q09665", "WBGene00006583", "O02159", "WBGene00020378", "G5EDZ8", "WBGene00000288", "Q94288", "WBGene00000287", "Q09980", "WBGene00017394", "O16305", "WBGene00000552", "G5EEG0", "WBGene00000286", "P22981", "WBGene00002335", "WBGene00003966", "Q18268", "WBGene00003966", "species_74016", "Q11083", "WBGene00020378", "P04630", "WBGene00000285", "G5EF37", "WBGene00003934", "A0A2C9C3L3", "WBGene00020378", "Q18136", "WBGene00006861", "Q09665", "WBGene00006583", "O02159", "WBGene00020378", "G5EDZ8", "WBGene00000288", "Q94288", "WBGene00000287", "Q09980", "WBGene00017394", "O16305", "WBGene00000552", "G5EEG0", "WBGene00000286", "P22981", "WBGene00002335", "Q18268", "WBGene00003966" ] }, "reaction_10572589": { "compartment": "compartment_70101", "id": "reaction_10572589", "reactome": "R-CEL-9647978", "name": "pro-RAS proteins are farnesylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10572579", "species_2530486" ], "products": [ "species_111294", "species_10572583" ], "modifiers": [ [ "species_10544771", "catalyst" ], [ "species_10572587", "inhibitor" ] ], "additional_components": [ "WBGene00002335", "WBGene00002335", "Q19752", "WBGene00006465", "O44501", "WBGene00019823", "Q19752", "WBGene00006465", "O44501", "WBGene00019823" ] }, "reaction_10572909": { "compartment": "compartment_876", "id": "reaction_10572909", "reactome": "R-CEL-9654533", "name": "KRAS4B recycles to the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10572900" ], "products": [ "species_10511479", "species_10508995", "species_10550993", "species_10553585" ], "modifiers": [], "additional_components": [ "species_29438", "Q19705", "WBGene00001358", "Q18268", "WBGene00003966", "species_74016", "Q11083", "WBGene00020378", "P04630", "WBGene00000285", "G5EF37", "WBGene00003934", "A0A2C9C3L3", "WBGene00020378", "Q18136", "WBGene00006861", "Q09665", "WBGene00006583", "O02159", "WBGene00020378", "G5EDZ8", "WBGene00000288", "Q94288", "WBGene00000287", "Q09980", "WBGene00017394", "O16305", "WBGene00000552", "G5EEG0", "WBGene00000286", "P22981", "WBGene00002335", "WBGene00002335", "species_74016", "Q11083", "WBGene00020378", "P04630", "WBGene00000285", "G5EF37", "WBGene00003934", "A0A2C9C3L3", "WBGene00020378", "Q18136", "WBGene00006861", "Q09665", "WBGene00006583", "O02159", "WBGene00020378", "G5EDZ8", "WBGene00000288", "Q94288", "WBGene00000287", "Q09980", "WBGene00017394", "O16305", "WBGene00000552", "G5EEG0", "WBGene00000286", "species_29438", "Q19705", "WBGene00001358", "WBGene00003966" ] }, "reaction_10572753": { "compartment": "compartment_70101", "id": "reaction_10572753", "reactome": "R-CEL-9653503", "name": "KRAS4B is phosphorylated on serine 181", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10511479" ], "products": [ "species_29370", "species_10572744" ], "modifiers": [ [ "species_10572750", "catalyst" ] ], "additional_components": [ "WBGene00002335", "WBGene00002335", "species_112275", "P34722", "WBGene00006599", "H2KYN2", "WBGene00015650", "O76360", "WBGene00001173", "species_30991" ] }, "reaction_10572881": { "compartment": "compartment_876", "id": "reaction_10572881", "reactome": "R-CEL-9653585", "name": "S-Farn-Me KRAS4B binds calmodulin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10511479", "species_10508995" ], "products": [ "species_10549080" ], "modifiers": [ [ "species_10572744", "inhibitor" ] ], "additional_components": [ "WBGene00002335", "species_74016", "Q11083", "WBGene00020378", "P04630", "WBGene00000285", "G5EF37", "WBGene00003934", "A0A2C9C3L3", "WBGene00020378", "Q18136", "WBGene00006861", "Q09665", "WBGene00006583", "O02159", "WBGene00020378", "G5EDZ8", "WBGene00000288", "Q94288", "WBGene00000287", "Q09980", "WBGene00017394", "O16305", "WBGene00000552", "G5EEG0", "WBGene00000286", "species_74016", "Q11083", "WBGene00020378", "P04630", "WBGene00000285", "G5EF37", "WBGene00003934", "A0A2C9C3L3", "WBGene00020378", "Q18136", "WBGene00006861", "Q09665", "WBGene00006583", "O02159", "WBGene00020378", "G5EDZ8", "WBGene00000288", "Q94288", "WBGene00000287", "Q09980", "WBGene00017394", "O16305", "WBGene00000552", "G5EEG0", "WBGene00000286", "P22981", "WBGene00002335", "WBGene00002335" ] }, "reaction_10572598": { "compartment": "compartment_876", "id": "reaction_10572598", "reactome": "R-CEL-9647980", "name": "mature RAS proteins translocate to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10572592" ], "products": [ "species_10511477" ], "modifiers": [], "additional_components": [ "WBGene00002335", "WBGene00002335" ] }, "reaction_10572886": { "compartment": "compartment_17906", "id": "reaction_10572886", "reactome": "R-CEL-9653592", "name": "pS181-S-Farn-Me KRAS4B translocates to the outer mitochondrial membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10572744" ], "products": [ "species_10572884" ], "modifiers": [], "additional_components": [ "WBGene00002335", "WBGene00002335" ] }, "reaction_10572696": { "compartment": "compartment_12045", "id": "reaction_10572696", "reactome": "R-CEL-9649732", "name": "Mature S-Farn-Me KRAS4B translocates to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10572572" ], "products": [ "species_10511479" ], "modifiers": [], "additional_components": [ "WBGene00002335", "WBGene00002335" ] }, "reaction_10572666": { "compartment": "compartment_876", "id": "reaction_10572666", "reactome": "R-CEL-9647991", "name": "Palmostatin B binds RAS depalmitoylases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9647934", "species_10572662" ], "products": [ "species_10572664" ], "modifiers": [], "additional_components": [ "Q9XVA7", "WBGene00044003", "Q21221", "WBGene00045192", "Q5FC17", "WBGene00044003", "Q7JKU8", "WBGene00044003", "Q9BL52", "WBGene00044003", "A0A061ACY0", "WBGene00010564", "Q9XVA7", "WBGene00044003", "Q21221", "WBGene00045192", "Q5FC17", "WBGene00044003", "Q7JKU8", "WBGene00044003", "Q9BL52", "WBGene00044003", "A0A061ACY0", "WBGene00010564" ] }, "reaction_10572698": { "compartment": "compartment_876", "id": "reaction_10572698", "reactome": "R-CEL-9649733", "name": "mature p21 RAS binds GDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10511471", "species_29420" ], "products": [ "species_10512175" ], "modifiers": [], "additional_components": [ "WBGene00002335", "species_29420", "P22981", "WBGene00002335" ] }, "reaction_10572890": { "compartment": "compartment_17906", "id": "reaction_10572890", "reactome": "R-CEL-9653595", "name": "pS181-S-Farn-Me KRAS4B binds BCL2L1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10572884", "species_10528114" ], "products": [ "species_10572888" ], "modifiers": [], "additional_components": [ "WBGene00002335", "WBGene00000423", "P41958", "WBGene00000423", "P22981", "WBGene00002335" ] }, "reaction_10572669": { "compartment": "compartment_876", "id": "reaction_10572669", "reactome": "R-CEL-9647994", "name": "RAS proteins are depalmitoylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10511477" ], "products": [ "species_10511479", "species_8848337" ], "modifiers": [ [ "species_10572662", "catalyst" ], [ "species_10572664", "inhibitor" ] ], "additional_components": [ "WBGene00002335", "WBGene00002335", "Q9XVA7", "WBGene00044003", "Q21221", "WBGene00045192", "Q5FC17", "WBGene00044003", "Q7JKU8", "WBGene00044003", "Q9BL52", "WBGene00044003", "A0A061ACY0", "WBGene00010564", "Q9XVA7", "WBGene00044003", "Q21221", "WBGene00045192", "Q5FC17", "WBGene00044003", "Q7JKU8", "WBGene00044003", "Q9BL52", "WBGene00044003", "A0A061ACY0", "WBGene00010564" ] }, "reaction_10554992": { "compartment": "compartment_876", "id": "reaction_10554992", "reactome": "R-CEL-5672965", "name": "RAS GEFs promote RAS nucleotide exchange", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10512175", "species_29438" ], "products": [ "species_29420", "species_10511481" ], "modifiers": [ [ "species_10554989", "catalyst" ] ], "additional_components": [ "species_29420", "P22981", "WBGene00002335", "species_29438", "P22981", "WBGene00002335", "P29355", "WBGene00004774", "Q9N5D3", "WBGene00004947", "P24348", "WBGene00002299", "species_114519", "Q19770", "WBGene00009100", "W6RS10", "WBGene00019902", "Q9N413", "WBGene00004249", "G5EGT9", "WBGene00003007", "A0A1I6CMA1", "WBGene00020678", "Q9XWK4", "WBGene00013202", "Q9XVQ7", "WBGene00008711", "E0AHA7", "WBGene00006803", "G5EFW3", "WBGene00004855", "Q21408", "WBGene00004951", "Q7YZG5", "WBGene00021702", "C6KRM7", "WBGene00004372", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q95YD4", "WBGene00002213", "G5EDB9", "WBGene00004254" ] }, "reaction_10572929": { "compartment": "compartment_876", "id": "reaction_10572929", "reactome": "R-CEL-9658253", "name": "RAS:GTP binds PI3K", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10506892", "species_10511481" ], "products": [ "species_10572927" ], "modifiers": [], "additional_components": [ "G5EDP9", "WBGene00000001", "Q94125", "WBGene00000090", "species_29438", "P22981", "WBGene00002335", "species_29438", "P22981", "WBGene00002335", "G5EDP9", "WBGene00000001", "Q94125", "WBGene00000090" ] }, "reaction_10542176": { "compartment": "compartment_70101", "id": "reaction_10542176", "reactome": "R-CEL-2032768", "name": "Translocation of WWTR1 (TAZ) to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10541983" ], "products": [ "species_10542174" ], "modifiers": [], "additional_components": [ "WBGene00008748", "WBGene00008748" ] }, "reaction_10542432": { "compartment": "compartment_70101", "id": "reaction_10542432", "reactome": "R-CEL-2066299", "name": "DVL2 binds phosphorylated WWTR1 (TAZ)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10515048", "species_10541986" ], "products": [ "species_10542430" ], "modifiers": [], "additional_components": [ "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "WBGene00008748", "Q19404", "WBGene00008748", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241" ] }, "reaction_10542178": { "compartment": "compartment_70101", "id": "reaction_10542178", "reactome": "R-CEL-2032770", "name": "Translocation of YAP1 to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10532629" ], "products": [ "species_10532633" ], "modifiers": [], "additional_components": [ "WBGene00008748", "WBGene00008748" ] }, "reaction_10542339": { "compartment": "compartment_70101", "id": "reaction_10542339", "reactome": "R-CEL-2064406", "name": "Translocation of YAP1:ZO-2 (TJP2) to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10542333" ], "products": [ "species_10542337" ], "modifiers": [], "additional_components": [ "Q19404", "WBGene00008748", "Q8I103", "WBGene00013683", "Q19404", "WBGene00008748", "Q8I103", "WBGene00013683" ] }, "reaction_10541988": { "compartment": "compartment_70101", "id": "reaction_10541988", "reactome": "R-CEL-2028661", "name": "Phosphorylation of WWTR1 (TAZ) by LATS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10541983", "species_113592" ], "products": [ "species_29370", "species_10541986" ], "modifiers": [ [ "species_10541961", "catalyst" ] ], "additional_components": [ "WBGene00008748", "WBGene00008748", "O45797", "WBGene00007047", "Q20186", "WBGene00009551" ] }, "reaction_10542345": { "compartment": "compartment_70101", "id": "reaction_10542345", "reactome": "R-CEL-2064417", "name": "WWTR1 (TAZ) binds ZO-1 (TJP1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10541983", "species_10542341" ], "products": [ "species_10542343" ], "modifiers": [], "additional_components": [ "WBGene00008748", "WBGene00013683", "Q8I103", "WBGene00013683", "Q19404", "WBGene00008748" ] }, "reaction_10541964": { "compartment": "compartment_70101", "id": "reaction_10541964", "reactome": "R-CEL-2028583", "name": "Phosphorylation of YAP by LATS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10532629" ], "products": [ "species_29370", "species_10541959" ], "modifiers": [ [ "species_10541961", "catalyst" ] ], "additional_components": [ "WBGene00008748", "WBGene00008748", "O45797", "WBGene00007047", "Q20186", "WBGene00009551" ] }, "reaction_10542349": { "compartment": "compartment_70101", "id": "reaction_10542349", "reactome": "R-CEL-2064418", "name": "WWTR1 (TAZ) binds ZO-2 (TJP2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10541983", "species_10542331" ], "products": [ "species_10542347" ], "modifiers": [], "additional_components": [ "WBGene00008748", "WBGene00013683", "Q8I103", "WBGene00013683", "Q19404", "WBGene00008748" ] }, "reaction_10542351": { "compartment": "compartment_70101", "id": "reaction_10542351", "reactome": "R-CEL-2064421", "name": "YAP1 binds ZO-2 (TJP2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10542331", "species_10532629" ], "products": [ "species_10542333" ], "modifiers": [], "additional_components": [ "WBGene00013683", "WBGene00008748", "Q19404", "WBGene00008748", "Q8I103", "WBGene00013683" ] }, "reaction_10541973": { "compartment": "compartment_70101", "id": "reaction_10541973", "reactome": "R-CEL-2028598", "name": "Phosphorylation of YAP by LATS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10532629" ], "products": [ "species_29370", "species_10541970" ], "modifiers": [ [ "species_10541956", "catalyst" ] ], "additional_components": [ "WBGene00008748", "WBGene00008748", "Q20186", "WBGene00009551", "O45797", "WBGene00007047" ] }, "reaction_10542327": { "compartment": "compartment_70101", "id": "reaction_10542327", "reactome": "R-CEL-2059926", "name": "NPHP4 protein binds LATS proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10541935", "species_10542323" ], "products": [ "species_10542325" ], "modifiers": [], "additional_components": [ "WBGene00007047", "WBGene00011261", "G5ECP0", "WBGene00011261", "O45797", "WBGene00007047" ] }, "reaction_10541975": { "compartment": "compartment_70101", "id": "reaction_10541975", "reactome": "R-CEL-2028626", "name": "Phosphorylated MOB1A proteins associate with LATS proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10541935", "species_10541944" ], "products": [ "species_10541946" ], "modifiers": [], "additional_components": [ "WBGene00007047", "WBGene00009551", "Q20186", "WBGene00009551", "O45797", "WBGene00007047" ] }, "reaction_10542329": { "compartment": "compartment_70101", "id": "reaction_10542329", "reactome": "R-CEL-2060328", "name": "Phosphorylation of WWTR1 (TAZ) by LATS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10541983", "species_113592" ], "products": [ "species_29370", "species_10541986" ], "modifiers": [ [ "species_10541956", "catalyst" ] ], "additional_components": [ "WBGene00008748", "WBGene00008748", "Q20186", "WBGene00009551", "O45797", "WBGene00007047" ] }, "reaction_10541981": { "compartment": "compartment_70101", "id": "reaction_10541981", "reactome": "R-CEL-2028644", "name": "YWHAB (14-3-3 beta/alpha) dimer binds phosphorylated YAP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10507067", "species_10541959" ], "products": [ "species_10541979" ], "modifiers": [], "additional_components": [ "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "WBGene00008748", "Q19404", "WBGene00008748", "P41932", "WBGene00003920", "Q20655", "WBGene00001502" ] }, "reaction_10573312": { "compartment": "compartment_263163", "id": "reaction_10573312", "reactome": "R-CEL-9706390", "name": "RHOBTB3 binds interacting proteins at trans-Golgi network", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10573308", "species_10573304" ], "products": [ "species_10573310" ], "modifiers": [], "additional_components": [ "O01501", "WBGene00000871", "Q19213", "WBGene00006922", "Q17796", "WBGene00004101", "Q22895", "WBGene00004780", "Q17391", "WBGene00000838", "Q03206", "ced-10", "Q94124", "WBGene00004287", "Q9BL44", "WBGene00022177", "species_29358", "Q03206", "ced-10", "Q94124", "WBGene00004287", "Q9BL44", "WBGene00022177", "species_29358", "O01501", "WBGene00000871", "Q19213", "WBGene00006922", "Q17796", "WBGene00004101", "Q22895", "WBGene00004780", "Q17391", "WBGene00000838" ] }, "reaction_10573314": { "compartment": "compartment_263163", "id": "reaction_10573314", "reactome": "R-CEL-9706393", "name": "RHOBTB3 binds ATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10573302" ], "products": [ "species_10573304" ], "modifiers": [], "additional_components": [ "Q03206", "ced-10", "Q94124", "WBGene00004287", "Q9BL44", "WBGene00022177", "Q03206", "ced-10", "Q94124", "WBGene00004287", "Q9BL44", "WBGene00022177", "species_29358" ] }, "reaction_10573319": { "compartment": "compartment_263163", "id": "reaction_10573319", "reactome": "R-CEL-9706399", "name": "RHOBTB3 hydrolyzes ATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10573304" ], "products": [ "species_29372", "species_10573316" ], "modifiers": [ [ "species_10573304", "catalyst" ] ], "additional_components": [ "Q03206", "ced-10", "Q94124", "WBGene00004287", "Q9BL44", "WBGene00022177", "species_29358", "Q03206", "ced-10", "Q94124", "WBGene00004287", "Q9BL44", "WBGene00022177", "species_113582", "Q03206", "ced-10", "Q94124", "WBGene00004287", "Q9BL44", "WBGene00022177", "species_29358" ] }, "reaction_10571460": { "compartment": "compartment_17906", "id": "reaction_10571460", "reactome": "R-CEL-9018815", "name": "RHOT1 binds effectors at the mitochondrial outer membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10571454", "species_10571444" ], "products": [ "species_10571458" ], "modifiers": [], "additional_components": [ "WBGene00020838", "Q94263", "WBGene00019544", "species_29438", "Q94263", "WBGene00019544", "species_29438", "P91503", "WBGene00020838" ] }, "reaction_10571449": { "compartment": "compartment_70101", "id": "reaction_10571449", "reactome": "R-CEL-9018814", "name": "RHOT1 hydrolyzes GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10571444" ], "products": [ "species_29372", "species_10571446" ], "modifiers": [ [ "species_10571444", "catalyst" ] ], "additional_components": [ "Q94263", "WBGene00019544", "species_29438", "Q94263", "WBGene00019544", "species_29420", "Q94263", "WBGene00019544", "species_29438" ] }, "reaction_10571466": { "compartment": "compartment_70101", "id": "reaction_10571466", "reactome": "R-CEL-9018824", "name": "RHOT2 binds effectors at the mitochondrial outer membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10571462", "species_10571444" ], "products": [ "species_10571464" ], "modifiers": [], "additional_components": [ "Q23424", "WBGene00001509", "P91503", "WBGene00020838", "Q94263", "WBGene00019544", "species_29438", "Q94263", "WBGene00019544", "species_29438", "Q23424", "WBGene00001509", "P91503", "WBGene00020838" ] }, "reaction_10571468": { "compartment": "compartment_70101", "id": "reaction_10571468", "reactome": "R-CEL-9018826", "name": "RHOT2 hydrolyzes GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10571444" ], "products": [ "species_29372", "species_10571446" ], "modifiers": [ [ "species_10571444", "catalyst" ] ], "additional_components": [ "Q94263", "WBGene00019544", "species_29438", "Q94263", "WBGene00019544", "species_29420", "Q94263", "WBGene00019544", "species_29438" ] }, "reaction_10564802": { "compartment": "compartment_70101", "id": "reaction_10564802", "reactome": "R-CEL-8849055", "name": "PTK6 binds ARHGAP35", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10564606", "species_10521590" ], "products": [ "species_10564800" ], "modifiers": [], "additional_components": [ "A0A0K3ARA3", "WBGene00020106", "Q10925", "WBGene00002207", "WBGene00010374", "O45611", "WBGene00010374", "A0A0K3ARA3", "WBGene00020106", "Q10925", "WBGene00002207" ] }, "reaction_10564808": { "compartment": "compartment_70101", "id": "reaction_10564808", "reactome": "R-CEL-8849068", "name": "PTK6 phosphorylates ARHGAP35", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10564800" ], "products": [ "species_10564606", "species_29370", "species_10564805" ], "modifiers": [ [ "species_10564800", "catalyst" ] ], "additional_components": [ "O45611", "WBGene00010374", "A0A0K3ARA3", "WBGene00020106", "Q10925", "WBGene00002207", "A0A0K3ARA3", "WBGene00020106", "Q10925", "WBGene00002207", "WBGene00010374", "O45611", "WBGene00010374", "A0A0K3ARA3", "WBGene00020106", "Q10925", "WBGene00002207" ] }, "reaction_10564731": { "compartment": "compartment_876", "id": "reaction_10564731", "reactome": "R-CEL-8848618", "name": "Activation of RAC1 by the PXN:CRK complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10541992" ], "products": [ "species_29420", "species_10509457" ], "modifiers": [ [ "species_10564728", "catalyst" ] ], "additional_components": [ "species_29420", "Q03206", "ced-10", "species_29438", "Q03206", "ced-10", "Q8STE5", "WBGene00000426", "Q95XA9", "WBGene00021238", "Q9NHC3", "WBGene00000416", "G5EEN3", "WBGene00000419" ] }, "reaction_10564813": { "compartment": "compartment_70101", "id": "reaction_10564813", "reactome": "R-CEL-8849082", "name": "ARHGAP35 stimulates RHOA GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10564810" ], "products": [ "species_10509486", "species_29372", "species_10564805" ], "modifiers": [ [ "species_10564810", "catalyst" ] ], "additional_components": [ "Q22038", "WBGene00004357", "species_29438", "O45611", "WBGene00010374", "Q22038", "WBGene00004357", "species_29420", "WBGene00010374", "Q22038", "WBGene00004357", "species_29438", "O45611", "WBGene00010374" ] }, "reaction_10564815": { "compartment": "compartment_70101", "id": "reaction_10564815", "reactome": "R-CEL-8849085", "name": "ARHGAP35 binds RHOA:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10564805", "species_10509488" ], "products": [ "species_10564810" ], "modifiers": [], "additional_components": [ "WBGene00010374", "Q22038", "WBGene00004357", "species_29438", "Q22038", "WBGene00004357", "species_29438", "O45611", "WBGene00010374" ] }, "reaction_10564769": { "compartment": "compartment_70101", "id": "reaction_10564769", "reactome": "R-CEL-8848818", "name": "PTK6 phosphorylates CBL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10512267", "species_113592" ], "products": [ "species_10528460", "species_29370" ], "modifiers": [ [ "species_10564606", "catalyst" ] ], "additional_components": [ "WBGene00004829", "WBGene00004829", "A0A0K3ARA3", "WBGene00020106", "Q10925", "WBGene00002207" ] }, "reaction_10564784": { "compartment": "compartment_70101", "id": "reaction_10564784", "reactome": "R-CEL-8848864", "name": "PTK6 binds ARAP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10564606", "species_10564780" ], "products": [ "species_10564782" ], "modifiers": [], "additional_components": [ "A0A0K3ARA3", "WBGene00020106", "Q10925", "WBGene00002207", "WBGene00017760", "H2KZV4", "WBGene00017760", "A0A0K3ARA3", "WBGene00020106", "Q10925", "WBGene00002207" ] }, "reaction_10564754": { "compartment": "compartment_70101", "id": "reaction_10564754", "reactome": "R-CEL-8848758", "name": "PTK6 phosphorylates AKT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10564733", "species_113592" ], "products": [ "species_10564751", "species_29370" ], "modifiers": [ [ "species_10564733", "catalyst" ] ], "additional_components": [ "G4S4W1", "WBGene00016980", "Q17941", "WBGene00000102", "Q9XTG7", "WBGene00000103", "A0A0K3ARA3", "WBGene00020106", "Q10925", "WBGene00002207", "G4S4W1", "WBGene00016980", "Q17941", "WBGene00000102", "Q9XTG7", "WBGene00000103", "A0A0K3ARA3", "WBGene00020106", "Q10925", "WBGene00002207", "G4S4W1", "WBGene00016980", "Q17941", "WBGene00000102", "Q9XTG7", "WBGene00000103", "A0A0K3ARA3", "WBGene00020106", "Q10925", "WBGene00002207" ] }, "reaction_10564775": { "compartment": "compartment_70101", "id": "reaction_10564775", "reactome": "R-CEL-8848829", "name": "CBL autoubiquitinates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10528460", "species_10502375" ], "products": [ "species_10564772" ], "modifiers": [ [ "species_10528460", "catalyst" ] ], "additional_components": [ "WBGene00004829", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "WBGene00004829", "WBGene00004829" ] }, "reaction_10564790": { "compartment": "compartment_70101", "id": "reaction_10564790", "reactome": "R-CEL-8848873", "name": "PTK6 phosphorylates ARAP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10564782", "species_113592" ], "products": [ "species_10564606", "species_29370", "species_10564787" ], "modifiers": [ [ "species_10564782", "catalyst" ] ], "additional_components": [ "H2KZV4", "WBGene00017760", "A0A0K3ARA3", "WBGene00020106", "Q10925", "WBGene00002207", "A0A0K3ARA3", "WBGene00020106", "Q10925", "WBGene00002207", "WBGene00017760", "H2KZV4", "WBGene00017760", "A0A0K3ARA3", "WBGene00020106", "Q10925", "WBGene00002207" ] }, "reaction_10564760": { "compartment": "compartment_70101", "id": "reaction_10564760", "reactome": "R-CEL-8848774", "name": "PTK6 binds DOK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10564606", "species_10564756" ], "products": [ "species_10564758" ], "modifiers": [], "additional_components": [ "A0A0K3ARA3", "WBGene00020106", "Q10925", "WBGene00002207", "WBGene00018819", "E6N0V1", "WBGene00018819", "A0A0K3ARA3", "WBGene00020106", "Q10925", "WBGene00002207" ] }, "reaction_10564735": { "compartment": "compartment_70101", "id": "reaction_10564735", "reactome": "R-CEL-8848751", "name": "PTK6 binds AKT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10564606", "species_10520798" ], "products": [ "species_10564733" ], "modifiers": [], "additional_components": [ "A0A0K3ARA3", "WBGene00020106", "Q10925", "WBGene00002207", "G4S4W1", "WBGene00016980", "Q17941", "WBGene00000102", "Q9XTG7", "WBGene00000103", "G4S4W1", "WBGene00016980", "Q17941", "WBGene00000102", "Q9XTG7", "WBGene00000103", "A0A0K3ARA3", "WBGene00020106", "Q10925", "WBGene00002207" ] }, "reaction_10564766": { "compartment": "compartment_70101", "id": "reaction_10564766", "reactome": "R-CEL-8848776", "name": "PTK6 phosphorylates DOK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10564758" ], "products": [ "species_10564606", "species_10564763", "species_29370" ], "modifiers": [ [ "species_10564758", "catalyst" ] ], "additional_components": [ "E6N0V1", "WBGene00018819", "A0A0K3ARA3", "WBGene00020106", "Q10925", "WBGene00002207", "A0A0K3ARA3", "WBGene00020106", "Q10925", "WBGene00002207", "WBGene00018819", "E6N0V1", "WBGene00018819", "A0A0K3ARA3", "WBGene00020106", "Q10925", "WBGene00002207" ] }, "reaction_10564930": { "compartment": "compartment_7660", "id": "reaction_10564930", "reactome": "R-CEL-8849463", "name": "PTK6 phosphorylates SFPQ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10564924" ], "products": [ "species_113582", "species_10564927" ], "modifiers": [ [ "species_10564796", "catalyst" ] ], "additional_components": [ "WBGene00017778", "WBGene00017778", "A0A0K3ARA3", "WBGene00020106", "Q10925", "WBGene00002207" ] }, "reaction_10564798": { "compartment": "compartment_70101", "id": "reaction_10564798", "reactome": "R-CEL-8848930", "name": "PTK6 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10564606" ], "products": [ "species_10564796" ], "modifiers": [], "additional_components": [ "A0A0K3ARA3", "WBGene00020106", "Q10925", "WBGene00002207", "A0A0K3ARA3", "WBGene00020106", "Q10925", "WBGene00002207" ] }, "reaction_10564828": { "compartment": "compartment_70101", "id": "reaction_10564828", "reactome": "R-CEL-8849102", "name": "SRMS phosphorylates PTK6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10564606", "species_113592" ], "products": [ "species_29370", "species_10564823" ], "modifiers": [ [ "species_10564825", "catalyst" ] ], "additional_components": [ "A0A0K3ARA3", "WBGene00020106", "Q10925", "WBGene00002207", "A0A0K3ARA3", "WBGene00020106", "Q10925", "WBGene00002207", "WBGene00020106" ] }, "reaction_10564610": { "compartment": "compartment_70101", "id": "reaction_10564610", "reactome": "R-CEL-8848110", "name": "SOCS3 binds activated PTK6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10564606", "species_10531061" ], "products": [ "species_10564608" ], "modifiers": [], "additional_components": [ "A0A0K3ARA3", "WBGene00020106", "Q10925", "WBGene00002207", "WBGene00009556", "O45498", "WBGene00009556", "A0A0K3ARA3", "WBGene00020106", "Q10925", "WBGene00002207" ] }, "reaction_10515265": { "compartment": "compartment_947587", "id": "reaction_10515265", "reactome": "R-CEL-202626", "name": "I-Smad competes with Co-Smad for R-Smad1/5/8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10515259", "species_10514789" ], "products": [ "species_10515263" ], "modifiers": [], "additional_components": [ "WBGene00006445", "Q02330", "WBGene00004856", "F5GUE5", "WBGene00000910", "P45896", "WBGene00004857", "Q02330", "WBGene00004856", "F5GUE5", "WBGene00000910", "P45896", "WBGene00004857", "G5EDS9", "WBGene00006445" ] }, "reaction_10514817": { "compartment": "compartment_7660", "id": "reaction_10514817", "reactome": "R-CEL-201425", "name": "Ubiquitin-dependent degradation of the Smad complex terminates BMP2 signalling", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10514815" ], "products": [], "modifiers": [ [ "species_10511544", "catalyst" ] ], "additional_components": [ "P45897", "WBGene00004858", "F5GUE5", "WBGene00000910", "P45896", "WBGene00004857", "Q02330", "WBGene00004856", "P35129", "WBGene00002344", "P91853", "WBGene00006732", "Q17720", "WBGene00006717", "Q20617", "WBGene00006719" ] }, "reaction_10514839": { "compartment": "compartment_13231", "id": "reaction_10514839", "reactome": "R-CEL-201472", "name": "The phospho-R-Smad1/5/8:Co-Smad transfers to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10514791" ], "products": [ "species_10514815" ], "modifiers": [], "additional_components": [ "Q02330", "WBGene00004856", "F5GUE5", "WBGene00000910", "P45896", "WBGene00004857", "P45897", "WBGene00004858", "P45897", "WBGene00004858", "F5GUE5", "WBGene00000910", "P45896", "WBGene00004857", "Q02330", "WBGene00004856" ] }, "reaction_10514793": { "compartment": "compartment_70101", "id": "reaction_10514793", "reactome": "R-CEL-201422", "name": "Phospho-R-Smad1/5/8 forms a complex with Co-Smad", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10511404", "species_10514789" ], "products": [ "species_10514791" ], "modifiers": [], "additional_components": [ "WBGene00004858", "Q02330", "WBGene00004856", "F5GUE5", "WBGene00000910", "P45896", "WBGene00004857", "Q02330", "WBGene00004856", "F5GUE5", "WBGene00000910", "P45896", "WBGene00004857", "P45897", "WBGene00004858" ] }, "reaction_10571958": { "compartment": "compartment_13231", "id": "reaction_10571958", "reactome": "R-CEL-9604308", "name": "NICD4 traffics to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10571948" ], "products": [ "species_10517150" ], "modifiers": [ [ "species_10571956", "inhibitor" ] ], "additional_components": [ "WBGene00019957", "WBGene00019957", "Q21850", "WBGene00019957", "Q20655", "WBGene00001502", "P41932", "WBGene00003920" ] }, "reaction_10571961": { "compartment": "compartment_70101", "id": "reaction_10571961", "reactome": "R-CEL-9604328", "name": "AKT1 phosphorylates NOTCH4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10571948", "species_113592" ], "products": [ "species_29370", "species_10571954" ], "modifiers": [ [ "species_10513843", "catalyst" ] ], "additional_components": [ "WBGene00019957", "WBGene00019957", "Q9XTG7", "WBGene00000103", "G4S4W1", "WBGene00016980", "Q17941", "WBGene00000102" ] }, "reaction_10546960": { "compartment": "compartment_20699", "id": "reaction_10546960", "reactome": "R-CEL-3247844", "name": "WNT ligands traffic to the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546918" ], "products": [ "species_10546940" ], "modifiers": [], "additional_components": [ "P34888", "WBGene00000857", "P34889", "WBGene00000858", "Q7YWX7", "WBGene00003246", "Q7YWX7", "WBGene00003246", "P34888", "WBGene00000857", "P34889", "WBGene00000858" ] }, "reaction_10548112": { "compartment": "compartment_876", "id": "reaction_10548112", "reactome": "R-CEL-3781943", "name": "WLS:WNT complex is internalized for maturation into exosomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546940" ], "products": [ "species_10548088" ], "modifiers": [], "additional_components": [ "Q7YWX7", "WBGene00003246", "P34888", "WBGene00000857", "P34889", "WBGene00000858", "Q7YWX7", "WBGene00003246", "P34888", "WBGene00000857", "P34889", "WBGene00000858" ] }, "reaction_10546848": { "compartment": "compartment_20699", "id": "reaction_10546848", "reactome": "R-CEL-3247836", "name": "Retromer recycles WLS to the Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546842" ], "products": [ "species_10546846" ], "modifiers": [], "additional_components": [ "Q7YWX7", "WBGene00003246", "Q9XW41", "WBGene00006503", "O01258", "WBGene00006931", "Q86D99", "WBGene00014234", "Q21053", "WBGene00006933", "Q9XW41", "WBGene00006503", "Q7YWX7", "WBGene00003246", "O01258", "WBGene00006931", "Q86D99", "WBGene00014234", "Q21053", "WBGene00006933" ] }, "reaction_10546913": { "compartment": "compartment_17963", "id": "reaction_10546913", "reactome": "R-CEL-3247837", "name": "WNT ligands traffic to the Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546890" ], "products": [ "species_10546906" ], "modifiers": [ [ "species_10546911", "catalyst" ] ], "additional_components": [ "P34888", "WBGene00000857", "P34889", "WBGene00000858", "P34888", "WBGene00000857", "P34889", "WBGene00000858", "WBGene00010670" ] }, "reaction_10546962": { "compartment": "compartment_171062", "id": "reaction_10546962", "reactome": "R-CEL-3247847", "name": "WLS is endocytosed to the early endosome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546922" ], "products": [ "species_10546835" ], "modifiers": [], "additional_components": [ "WBGene00003246", "WBGene00003246" ] }, "reaction_10546916": { "compartment": "compartment_171062", "id": "reaction_10546916", "reactome": "R-CEL-3247839", "name": "Retromer associates with WLS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546830", "species_10546840", "species_10546835" ], "products": [ "species_10546842" ], "modifiers": [], "additional_components": [ "O01258", "WBGene00006931", "Q86D99", "WBGene00014234", "Q21053", "WBGene00006933", "WBGene00006503", "WBGene00003246", "Q7YWX7", "WBGene00003246", "Q9XW41", "WBGene00006503", "O01258", "WBGene00006931", "Q86D99", "WBGene00014234", "Q21053", "WBGene00006933" ] }, "reaction_10546964": { "compartment": "compartment_20699", "id": "reaction_10546964", "reactome": "R-CEL-3247849", "name": "WLS dissociates from retromer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546846" ], "products": [ "species_10546830", "species_10546844", "species_10546840" ], "modifiers": [], "additional_components": [ "Q9XW41", "WBGene00006503", "Q7YWX7", "WBGene00003246", "O01258", "WBGene00006931", "Q86D99", "WBGene00014234", "Q21053", "WBGene00006933", "O01258", "WBGene00006931", "Q86D99", "WBGene00014234", "Q21053", "WBGene00006933", "WBGene00003246", "WBGene00006503" ] }, "reaction_10546920": { "compartment": "compartment_20699", "id": "reaction_10546920", "reactome": "R-CEL-3247840", "name": "WLS binds WNT ligands in the Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546844", "species_10546906" ], "products": [ "species_10546918" ], "modifiers": [], "additional_components": [ "WBGene00003246", "P34888", "WBGene00000857", "P34889", "WBGene00000858", "P34888", "WBGene00000857", "P34889", "WBGene00000858", "Q7YWX7", "WBGene00003246" ] }, "reaction_10548110": { "compartment": "compartment_383505", "id": "reaction_10548110", "reactome": "R-CEL-3781941", "name": "WNTs are secreted in exosomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10548088" ], "products": [ "species_10548108" ], "modifiers": [], "additional_components": [ "Q7YWX7", "WBGene00003246", "P34888", "WBGene00000857", "P34889", "WBGene00000858", "Q7YWX7", "WBGene00003246", "P34888", "WBGene00000857", "P34889", "WBGene00000858" ] }, "reaction_10546958": { "compartment": "compartment_984", "id": "reaction_10546958", "reactome": "R-CEL-3247843", "name": "secretion of WNT ligands", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546940" ], "products": [ "species_10546956", "species_10546922" ], "modifiers": [], "additional_components": [ "Q7YWX7", "WBGene00003246", "P34888", "WBGene00000857", "P34889", "WBGene00000858", "Q27886", "WBGene00003029", "Q10459", "WBGene00003395", "G5EG05", "WBGene00001188", "P34888", "WBGene00000857", "P34889", "WBGene00000858", "WBGene00003246" ] }, "reaction_10549441": { "compartment": "compartment_70101", "id": "reaction_10549441", "reactome": "R-CEL-4641159", "name": "DVL1 is ubiquitinated by HECW1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10549434", "species_10502375" ], "products": [ "species_10549438" ], "modifiers": [ [ "species_10549434", "catalyst" ] ], "additional_components": [ "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "Q09291", "WBGene00009738", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "A0A0K3AUI8", "C34F11.9e", "Q09291", "WBGene00009738", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "Q09291", "WBGene00009738" ] }, "reaction_10549445": { "compartment": "compartment_70101", "id": "reaction_10549445", "reactome": "R-CEL-4641260", "name": "Ubiquitinated DVL1 is degraded by the proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10549438" ], "products": [ "species_10549432", "species_10502375" ], "modifiers": [ [ "species_10502572", "catalyst" ] ], "additional_components": [ "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "A0A0K3AUI8", "C34F11.9e", "Q09291", "WBGene00009738", "WBGene00009738", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "P91477", "WBGene00003950", "Q95PZ7", "WBGene00013435", "Q18115", "WBGene00004459", "O62102", "WBGene00003948", "O17071", "WBGene00004504", "Q10920", "WBGene00016623", "P34286", "WBGene00003952", "Q9XTT9", "WBGene00004506", "Q23449", "WBGene00004468", "Q95005", "WBGene00003925", "P46502", "WBGene00004503", "O61792", "WBGene00004464", "O17586", "WBGene00003922", "O76371", "WBGene00004505", "Q20585", "WBGene00004463", "Q95008", "WBGene00003926", "Q18787", "WBGene00004501", "Q20058", "WBGene00009445", "Q9N599", "WBGene00003924", "O16368", "WBGene00004502", "O61742", "WBGene00004466", "Q09583", "WBGene00003928", "Q966I8", "WBGene00003947", "Q04908", "WBGene00004460", "Q9XUV0", "WBGene00003951", "Q27488", "WBGene00003923", "Q9GZH5", "WBGene00004458", "O44156", "WBGene00003927", "Q22253", "WBGene00004465", "O76577", "WBGene00004467", "P90868", "WBGene00003953", "Q19324", "WBGene00004461", "Q17971", "WBGene00007588", "Q23237", "WBGene00003949", "Q20938", "WBGene00004462" ] }, "reaction_10535195": { "compartment": "compartment_70101", "id": "reaction_10535195", "reactome": "R-CEL-1504190", "name": "DVL is ubiquitinated by CUL3:KLHL12:RBX1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10535167", "species_10502375" ], "products": [ "species_10535192" ], "modifiers": [ [ "species_10535167", "catalyst" ] ], "additional_components": [ "Q23457", "WBGene00004320", "Q17391", "WBGene00000838", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "Q23457", "WBGene00004320", "Q17391", "WBGene00000838", "Q23457", "WBGene00004320", "Q17391", "WBGene00000838", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241" ] }, "reaction_10549436": { "compartment": "compartment_70101", "id": "reaction_10549436", "reactome": "R-CEL-4641155", "name": "DVL1 is bound by the HECT ubiquitin ligase HECW1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10549432", "species_10515040" ], "products": [ "species_10549434" ], "modifiers": [], "additional_components": [ "WBGene00009738", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "Q09291", "WBGene00009738" ] }, "reaction_10547556": { "compartment": "compartment_7660", "id": "reaction_10547556", "reactome": "R-CEL-3364026", "name": "SET1 complex trimethylates H3K4 at the MYC gene", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10547529" ], "products": [ "species_77502", "species_10547533" ], "modifiers": [ [ "species_10547553", "catalyst" ] ], "additional_components": [ "P62784", "WBGene00001875", "P62784", "WBGene00001875", "G5EFZ3", "WBGene00012458", "Q10666", "WBGene00004077", "Q09309", "WBGene00017683", "O44326", "WBGene00001979", "G5EGI1", "WBGene00011729", "O44447", "WBGene00015330" ] }, "reaction_10547174": { "compartment": "compartment_7660", "id": "reaction_10547174", "reactome": "R-CEL-3299569", "name": "Beta-catenin displaces TLE:HDAC1 from TCF/LEF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10514938", "species_10547170" ], "products": [ "species_10547166", "species_10532119", "species_10547172" ], "modifiers": [], "additional_components": [ "WBGene00001979", "G5ECH0", "WBGene00001836", "O02482", "WBGene00006773", "Q10666", "WBGene00004077", "O02482", "WBGene00006773", "WBGene00001836", "Q10666", "WBGene00004077", "O44326", "WBGene00001979" ] }, "reaction_10547387": { "compartment": "compartment_7660", "id": "reaction_10547387", "reactome": "R-CEL-3322424", "name": "Beta-catenin recruits CDC73 and LEO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509311", "species_10509321", "species_10547172" ], "products": [ "species_10547385" ], "modifiers": [], "additional_components": [ "WBGene00018064", "WBGene00007110", "Q10666", "WBGene00004077", "O44326", "WBGene00001979", "Q10666", "WBGene00004077", "O44326", "WBGene00001979", "Q17431", "WBGene00007110", "Q9N5U5", "WBGene00018064" ] }, "reaction_10547391": { "compartment": "compartment_7660", "id": "reaction_10547391", "reactome": "R-CEL-3322427", "name": "Beta-catenin recruits CBP/p300", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10547172", "species_10532226" ], "products": [ "species_10547389" ], "modifiers": [], "additional_components": [ "Q10666", "WBGene00004077", "O44326", "WBGene00001979", "WBGene00000366", "P34545", "WBGene00000366", "Q10666", "WBGene00004077", "O44326", "WBGene00001979" ] }, "reaction_10514940": { "compartment": "compartment_70101", "id": "reaction_10514940", "reactome": "R-CEL-201669", "name": "Beta-catenin translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10513633" ], "products": [ "species_10514938" ], "modifiers": [], "additional_components": [ "WBGene00001979", "WBGene00001979" ] }, "reaction_10553858": { "compartment": "compartment_7660", "id": "reaction_10553858", "reactome": "R-CEL-5626938", "name": "Beta-catenin binds SOX proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10553854", "species_10514938" ], "products": [ "species_10553856" ], "modifiers": [], "additional_components": [ "Q8T3B9", "WBGene00004771", "A0A1N7SZG1", "WBGene00015716", "Q20201", "WBGene00004950", "Q21305", "WBGene00004949", "Q23045", "WBGene00001182", "WBGene00001979", "O44326", "WBGene00001979", "Q8T3B9", "WBGene00004771", "A0A1N7SZG1", "WBGene00015716", "Q20201", "WBGene00004950", "Q21305", "WBGene00004949", "Q23045", "WBGene00001182" ] }, "reaction_10554594": { "compartment": "compartment_7660", "id": "reaction_10554594", "reactome": "R-CEL-5665608", "name": "TCF:Beta-catenin binds SOX proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10554590", "species_10547172" ], "products": [ "species_10554592" ], "modifiers": [], "additional_components": [ "Q8T3B9", "WBGene00004771", "A0A1N7SZG1", "WBGene00015716", "Q20201", "WBGene00004950", "Q21305", "WBGene00004949", "Q23045", "WBGene00001182", "Q10666", "WBGene00004077", "O44326", "WBGene00001979", "Q10666", "WBGene00004077", "O44326", "WBGene00001979", "Q8T3B9", "WBGene00004771", "A0A1N7SZG1", "WBGene00015716", "Q20201", "WBGene00004950", "Q21305", "WBGene00004949", "Q23045", "WBGene00001182" ] }, "reaction_10547479": { "compartment": "compartment_7660", "id": "reaction_10547479", "reactome": "R-CEL-3361751", "name": "beta-catenin is replaced by repression complexes at the promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10547475", "species_10547473" ], "products": [ "species_10547477", "species_10547170" ], "modifiers": [], "additional_components": [ "O02482", "WBGene00006773", "G5ECH0", "WBGene00001836", "Q10666", "WBGene00004077", "O44326", "WBGene00001979", "Q21227", "WBGene00000156", "Q20595", "WBGene00006424", "O44326", "WBGene00001979", "Q21227", "WBGene00000156", "Q20595", "WBGene00006424", "G5ECH0", "WBGene00001836", "O02482", "WBGene00006773", "Q10666", "WBGene00004077" ] }, "reaction_10547948": { "compartment": "compartment_70101", "id": "reaction_10547948", "reactome": "R-CEL-3769392", "name": "YWHAZ and XPO1 mediate the nuclear export of beta-catenin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10547940" ], "products": [ "species_10547946" ], "modifiers": [], "additional_components": [ "Q23089", "WBGene00002078", "O44326", "WBGene00001979", "Q20655", "WBGene00001502", "P41932", "WBGene00003920", "O44326", "WBGene00001979", "Q20655", "WBGene00001502", "P41932", "WBGene00003920", "Q23089", "WBGene00002078" ] }, "reaction_10551790": { "compartment": "compartment_7660", "id": "reaction_10551790", "reactome": "R-CEL-5368580", "name": "CHD8 binds beta-catenin to negatively regulate WNT-dependent gene expression", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10551786", "species_10514938" ], "products": [ "species_10551788" ], "modifiers": [], "additional_components": [ "WBGene00007053", "WBGene00001979", "O44326", "WBGene00001979", "O61845", "WBGene00007053" ] }, "reaction_10524625": { "compartment": "compartment_876", "id": "reaction_10524625", "reactome": "R-CEL-444393", "name": "RhCG mediates ammonium influx into kidney collecting duct cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_140912" ], "products": [ "species_351626", "species_31633" ], "modifiers": [ [ "species_10524622", "catalyst" ] ], "additional_components": [ "Q17463", "WBGene00004359", "Q22947", "WBGene00004358" ] }, "reaction_10525188": { "compartment": "compartment_876", "id": "reaction_10525188", "reactome": "R-CEL-446277", "name": "RhCG mediates ammonium efflux out of kidney collecting duct cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_31633" ], "products": [ "species_70106", "species_140912" ], "modifiers": [ [ "species_10524622", "catalyst" ] ], "additional_components": [ "Q17463", "WBGene00004359", "Q22947", "WBGene00004358" ] }, "reaction_10525190": { "compartment": "compartment_876", "id": "reaction_10525190", "reactome": "R-CEL-446278", "name": "RhBG mediates ammonium influx into kidney collecting duct cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_140912" ], "products": [ "species_351626", "species_31633" ], "modifiers": [ [ "species_10524636", "catalyst" ] ], "additional_components": [ "WBGene00004358" ] }, "reaction_10524634": { "compartment": "compartment_876", "id": "reaction_10524634", "reactome": "R-CEL-444416", "name": "RHAG transports NH4+ from cytosol to extracellular region (red blood cells)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_31633" ], "products": [ "species_140912" ], "modifiers": [ [ "species_10524631", "catalyst" ] ], "additional_components": [ "Q17463", "WBGene00004359", "Q22947", "WBGene00004358" ] }, "reaction_10524639": { "compartment": "compartment_876", "id": "reaction_10524639", "reactome": "R-CEL-444419", "name": "RhBG mediates ammonium effflux out of kidney collecting duct cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_31633" ], "products": [ "species_70106", "species_140912" ], "modifiers": [ [ "species_10524636", "catalyst" ] ], "additional_components": [ "WBGene00004358" ] }, "reaction_10524112": { "compartment": "compartment_876", "id": "reaction_10524112", "reactome": "R-CEL-433101", "name": "NaDC3 co-transports the dicarboxylic acid succinate and three sodium ion", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_433123", "species_74113" ], "products": [ "species_29434", "species_83910" ], "modifiers": [ [ "species_10524109", "catalyst" ] ], "additional_components": [ "P32739", "WBGene00003518", "P46556", "WBGene00007138", "Q21339", "WBGene00003519", "Q93655", "WBGene00003517" ] }, "reaction_10524130": { "compartment": "compartment_876", "id": "reaction_10524130", "reactome": "R-CEL-433114", "name": "NaS1 co-transports sulphate and a sodium ion", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_427648", "species_74113" ], "products": [ "species_83910", "species_174375" ], "modifiers": [ [ "species_10524127", "catalyst" ] ], "additional_components": [ "P32739", "WBGene00003518", "P46556", "WBGene00007138", "Q21339", "WBGene00003519", "Q93655", "WBGene00003517" ] }, "reaction_10524099": { "compartment": "compartment_876", "id": "reaction_10524099", "reactome": "R-CEL-433099", "name": "NaS2 co-transports sulphate and two sodium ions", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_427648", "species_74113" ], "products": [ "species_83910", "species_174375" ], "modifiers": [ [ "species_10524096", "catalyst" ] ], "additional_components": [ "P46556", "WBGene00007138", "Q21339", "WBGene00003519", "Q93655", "WBGene00003517", "P32739", "WBGene00003518" ] }, "reaction_10524117": { "compartment": "compartment_876", "id": "reaction_10524117", "reactome": "R-CEL-433104", "name": "NACT co-transports trivalent citrate and a sodium ion", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_433138", "species_74113" ], "products": [ "species_76190", "species_83910" ], "modifiers": [ [ "species_10524114", "catalyst" ] ], "additional_components": [ "WBGene00003517" ] }, "reaction_10524143": { "compartment": "compartment_876", "id": "reaction_10524143", "reactome": "R-CEL-433131", "name": "NaDC1 co-transports dicarboxylic acids and a sodium ion", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_433111", "species_74113" ], "products": [ "species_83910", "species_433124" ], "modifiers": [ [ "species_10524140", "catalyst" ] ], "additional_components": [ "species_76190", "species_1650769", "species_1650769", "species_76190", "P32739", "WBGene00003518", "P46556", "WBGene00007138", "Q21339", "WBGene00003519", "Q93655", "WBGene00003517" ] }, "reaction_10523391": { "compartment": "compartment_876", "id": "reaction_10523391", "reactome": "R-CEL-429101", "name": "HMIT co-transports myo-inositol with a proton", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_429130" ], "products": [ "species_70106", "species_426910" ], "modifiers": [ [ "species_10523388", "catalyst" ] ], "additional_components": [ "WBGene00010811" ] }, "reaction_10524074": { "compartment": "compartment_876", "id": "reaction_10524074", "reactome": "R-CEL-433089", "name": "SOAT can transport taurolithocholate-3-sulphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_433120", "species_74113" ], "products": [ "species_83910", "species_176483" ], "modifiers": [ [ "species_10524071", "catalyst" ] ], "additional_components": [ "WBGene00044650" ] }, "reaction_10524593": { "compartment": "compartment_876", "id": "reaction_10524593", "reactome": "R-CEL-444160", "name": "VMAT1/2 can mediate the transport of biogenic amines", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_444154" ], "products": [ "species_444152" ], "modifiers": [ [ "species_10524590", "catalyst" ] ], "additional_components": [ "species_351601", "species_209794", "species_380585", "species_390899", "species_209789", "species_209789", "species_209794", "species_390899", "species_351601", "species_380585", "WBGene00000295" ] }, "reaction_10524580": { "compartment": "compartment_876", "id": "reaction_10524580", "reactome": "R-CEL-443997", "name": "SLC6A2 cotransports NAd, Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_374935", "species_74113" ], "products": [ "species_209789", "species_83910" ], "modifiers": [ [ "species_10524577", "catalyst" ] ], "additional_components": [ "WBGene00000934" ] }, "reaction_10518791": { "compartment": "compartment_876", "id": "reaction_10518791", "reactome": "R-CEL-374896", "name": "Uptake of Noradrenaline", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_374935" ], "products": [ "species_209789" ], "modifiers": [ [ "species_10518786", "catalyst" ] ], "additional_components": [ "WBGene00003987" ] }, "reaction_10524651": { "compartment": "compartment_984", "id": "reaction_10524651", "reactome": "R-CEL-444433", "name": "Cho transports from the extracellular space to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_264638" ], "products": [ "species_264618" ], "modifiers": [ [ "species_10524644", "catalyst" ] ], "additional_components": [ "WBGene00018037" ] }, "reaction_10527456": { "compartment": "compartment_876", "id": "reaction_10527456", "reactome": "R-CEL-549304", "name": "OCT3 mediates renal clearance of organic cations", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_549326" ], "products": [ "species_549255" ], "modifiers": [ [ "species_10527453", "catalyst" ] ], "additional_components": [ "CHEBI:8428", "CHEBI:46020", "CHEBI:42820", "CHEBI:47499", "CHEBI:47781", "CHEBI:641", "CHEBI:46631", "CHEBI:47781", "CHEBI:8428", "CHEBI:42820", "CHEBI:47499", "CHEBI:641", "CHEBI:46020", "CHEBI:46631", "WBGene00003987" ] }, "reaction_10527408": { "compartment": "compartment_876", "id": "reaction_10527408", "reactome": "R-CEL-549241", "name": "SLC22A4 cotransports ERGT, Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_549261", "species_74113" ], "products": [ "species_83910", "species_549260" ], "modifiers": [ [ "species_10527400", "catalyst" ], [ "species_10527406", "inhibitor" ] ], "additional_components": [ "Q4PIX1", "WBGene00044455", "Q9BKR9", "WBGene00044455", "Q9U539", "WBGene00003842", "Q9UAW9", "WBGene00044455", "A0A0K3AWD3", "WBGene00044455", "A0A238UKL7", "WBGene00044455", "G5EEI9", "WBGene00044455", "G5EGL6", "WBGene00044455", "O18247", "WBGene00044455", "P46499", "WBGene00044455", "Q09617", "WBGene00044455", "Q18613", "WBGene00044455", "Q18655", "WBGene00044455", "Q18795", "WBGene00008271", "Q23501", "WBGene00003843", "WBGene00004393" ] }, "reaction_10527537": { "compartment": "compartment_876", "id": "reaction_10527537", "reactome": "R-CEL-597628", "name": "SLC22A18 exchanges extracellular organic cations for cytosolic H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_597604", "species_70106" ], "products": [ "species_351626", "species_597623" ], "modifiers": [ [ "species_10527534", "catalyst" ] ], "additional_components": [ "WBGene00008273" ] }, "reaction_10527458": { "compartment": "compartment_876", "id": "reaction_10527458", "reactome": "R-CEL-549322", "name": "OCT1 transports organic cations out of hepatic cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_549250" ], "products": [ "species_549264" ], "modifiers": [ [ "species_10518788", "catalyst" ] ], "additional_components": [ "species_351601", "species_209794", "CHEBI:46020", "CHEBI:42820", "CHEBI:6801", "species_549282", "species_6798162", "CHEBI:65133", "CHEBI:15854", "species_141324", "CHEBI:641", "species_390899", "species_353560", "species_209789", "CHEBI:42820", "CHEBI:641", "CHEBI:46020", "species_351601", "CHEBI:6801", "species_209794", "species_141324", "CHEBI:15854", "species_209789", "CHEBI:65133", "species_390899", "species_353560", "species_6798162", "species_549282", "WBGene00003987" ] }, "reaction_10527507": { "compartment": "compartment_876", "id": "reaction_10527507", "reactome": "R-CEL-561072", "name": "OCT3 mediates renal uptake of organic cations", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_549255" ], "products": [ "species_549326" ], "modifiers": [ [ "species_10527453", "catalyst" ] ], "additional_components": [ "CHEBI:47781", "CHEBI:8428", "CHEBI:42820", "CHEBI:47499", "CHEBI:641", "CHEBI:46020", "CHEBI:46631", "CHEBI:8428", "CHEBI:46020", "CHEBI:42820", "CHEBI:47499", "CHEBI:47781", "CHEBI:641", "CHEBI:46631", "WBGene00003987" ] }, "reaction_10527412": { "compartment": "compartment_876", "id": "reaction_10527412", "reactome": "R-CEL-549279", "name": "OCT2 mediates tubular uptake of organic cations in the kidney", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_549237" ], "products": [ "species_549266" ], "modifiers": [ [ "species_10518786", "catalyst" ] ], "additional_components": [ "CHEBI:31941", "CHEBI:16737", "CHEBI:641", "CHEBI:46020", "species_351601", "CHEBI:6801", "species_209794", "species_209789", "CHEBI:65133", "species_351164", "species_390899", "species_6798162", "species_549282", "species_380585", "species_351601", "species_209794", "CHEBI:46020", "CHEBI:6801", "species_549282", "CHEBI:16737", "species_6798162", "CHEBI:65133", "CHEBI:641", "species_380585", "species_351164", "species_390899", "CHEBI:31941", "species_209789", "WBGene00003987" ] }, "reaction_10527494": { "compartment": "compartment_876", "id": "reaction_10527494", "reactome": "R-CEL-561054", "name": "OCT2 mediates tubular secretion of organic cations in the kidney", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_549266" ], "products": [ "species_549237" ], "modifiers": [ [ "species_10518786", "catalyst" ] ], "additional_components": [ "species_351601", "species_209794", "CHEBI:46020", "CHEBI:6801", "species_549282", "CHEBI:16737", "species_6798162", "CHEBI:65133", "CHEBI:641", "species_380585", "species_351164", "species_390899", "CHEBI:31941", "species_209789", "CHEBI:31941", "CHEBI:16737", "CHEBI:641", "CHEBI:46020", "species_351601", "CHEBI:6801", "species_209794", "species_209789", "CHEBI:65133", "species_351164", "species_390899", "species_6798162", "species_549282", "species_380585", "WBGene00003987" ] }, "reaction_10527451": { "compartment": "compartment_876", "id": "reaction_10527451", "reactome": "R-CEL-549297", "name": "SLC22A4, 5,15,16 cotransport CAR, Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_164988", "species_74113" ], "products": [ "species_30235", "species_83910" ], "modifiers": [ [ "species_10527448", "catalyst" ] ], "additional_components": [ "P46499", "WBGene00044455", "Q09617", "WBGene00044455", "Q18613", "WBGene00044455", "Q18655", "WBGene00044455", "Q18795", "WBGene00008271", "Q23501", "WBGene00003843", "Q4PIX1", "WBGene00044455", "Q9BKR9", "WBGene00044455", "Q9U539", "WBGene00003842", "Q9UAW9", "WBGene00044455", "A0A0K3AWD3", "WBGene00044455", "A0A238UKL7", "WBGene00044455", "G5EEI9", "WBGene00044455", "G5EGL6", "WBGene00044455", "O18247", "WBGene00044455" ] }, "reaction_10527343": { "compartment": "compartment_876", "id": "reaction_10527343", "reactome": "R-CEL-549129", "name": "OCT1 transports organic cations into hepatic cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_549264" ], "products": [ "species_549250" ], "modifiers": [ [ "species_10518788", "catalyst" ] ], "additional_components": [ "CHEBI:42820", "CHEBI:641", "CHEBI:46020", "species_351601", "CHEBI:6801", "species_209794", "species_141324", "CHEBI:15854", "species_209789", "CHEBI:65133", "species_390899", "species_353560", "species_6798162", "species_549282", "species_351601", "species_209794", "CHEBI:46020", "CHEBI:42820", "CHEBI:6801", "species_549282", "species_6798162", "CHEBI:65133", "CHEBI:15854", "species_141324", "CHEBI:641", "species_390899", "species_353560", "species_209789", "WBGene00003987" ] }, "reaction_10527505": { "compartment": "compartment_876", "id": "reaction_10527505", "reactome": "R-CEL-561059", "name": "OAT2 and OAT4 mediate transport of sulphate conjugates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29406", "species_561071" ], "products": [ "species_561062", "species_561075" ], "modifiers": [ [ "species_10527502", "catalyst" ] ], "additional_components": [ "species_176496", "species_176501", "species_176501", "species_176496", "Q10917", "WBGene00020701", "Q22686", "WBGene00020701" ] }, "reaction_10527492": { "compartment": "compartment_876", "id": "reaction_10527492", "reactome": "R-CEL-561041", "name": "OAT1-3 transport organic anions with antiport of dicarboxylic acids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29406", "species_561049" ], "products": [ "species_561078", "species_561075" ], "modifiers": [ [ "species_10527489", "catalyst" ] ], "additional_components": [ "CHEBI:104011", "species_561052", "species_561052", "CHEBI:104011", "Q22686", "WBGene00020701", "Q10917", "WBGene00020701" ] }, "reaction_10527516": { "compartment": "compartment_876", "id": "reaction_10527516", "reactome": "R-CEL-561253", "name": "SLC22A12 exchanges extracellular urate for cytosolic LACT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29708", "species_429056" ], "products": [ "species_373863", "species_30034" ], "modifiers": [ [ "species_10527513", "catalyst" ] ], "additional_components": [ "Q10917", "WBGene00020701", "Q22686", "WBGene00020701" ] }, "reaction_10523423": { "compartment": "compartment_876", "id": "reaction_10523423", "reactome": "R-CEL-429594", "name": "SLC5A7 cotransports Cho, Cl-, Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_188972", "species_264638", "species_74113" ], "products": [ "species_264618", "species_83910", "species_352022" ], "modifiers": [ [ "species_10523420", "catalyst" ] ], "additional_components": [ "WBGene00000501" ] }, "reaction_10515237": { "compartment": "compartment_70101", "id": "reaction_10515237", "reactome": "R-CEL-202354", "name": "Translocation of PLC-gamma1 to PIP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10515230", "species_179856" ], "products": [ "species_10515235" ], "modifiers": [], "additional_components": [ "WBGene00004038", "Q22070", "WBGene00004038", "species_179856" ] }, "reaction_10515245": { "compartment": "compartment_70101", "id": "reaction_10515245", "reactome": "R-CEL-202407", "name": "PLC-gamma1 hydrolyses PIP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_179856" ], "products": [ "species_114520", "species_112275" ], "modifiers": [ [ "species_10515242", "catalyst" ] ], "additional_components": [ "WBGene00004038" ] }, "reaction_10529204": { "compartment": "compartment_74700", "id": "reaction_10529204", "reactome": "R-CEL-917841", "name": "Acidification of Tf:TfR1 containing endosome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_70106", "species_113592" ], "products": [ "species_29372", "species_29370", "species_74722" ], "modifiers": [ [ "species_10506845", "catalyst" ] ], "additional_components": [ "G5EGP4", "WBGene00006915", "P30628", "WBGene00006768", "B2MZD0", "WBGene00006916", "G5EEK9", "WBGene00006914", "C0HLB3", "WBGene00006911", "C0HLB4", "WBGene00006912", "G5EDB8", "WBGene00006913", "Q95YD5", "WBGene00016258", "Q20591", "WBGene00009882", "Q9XXU9", "WBGene00006920", "Q22494", "WBGene00020507", "Q23680", "WBGene00006918", "P34462", "WBGene00010130", "Q9XW92", "WBGene00013025", "Q19626", "WBGene00006921", "Q9N5A0", "WBGene00004959", "Q95X44", "WBGene00006917", "P91303", "WBGene00006919", "Q9TYW1", "WBGene00021952" ] }, "reaction_10529221": { "compartment": "compartment_74700", "id": "reaction_10529221", "reactome": "R-CEL-917936", "name": "MCOLN1 transports Fe2+ from endosome lumen to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_917810" ], "products": [ "species_71067" ], "modifiers": [ [ "species_10529218", "catalyst" ] ], "additional_components": [ "WBGene00000846" ] }, "reaction_10543223": { "compartment": "compartment_984", "id": "reaction_10543223", "reactome": "R-CEL-2168886", "name": "Hemopexin binds Hemes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9707310", "species_10543219" ], "products": [ "species_10543221" ], "modifiers": [], "additional_components": [ "species_71185", "Q21182", "WBGene00194737", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "Q21182", "WBGene00194737", "A0A0K3ARD1", "WBGene00194737", "G5EBU3", "WBGene00016283", "G5ECC4", "WBGene00020646", "G5EGM1", "WBGene00006987", "O62390", "WBGene00194737", "species_71185" ] }, "reaction_10503456": { "compartment": "compartment_5460", "id": "reaction_10503456", "reactome": "R-CEL-70859", "name": "isobutyryl-CoA + FAD => methacrylyl-CoA + FADH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113596", "species_70851" ], "products": [ "species_70858", "species_31649" ], "modifiers": [ [ "species_10503453", "catalyst" ] ], "additional_components": [ "Q95YB2", "WBGene00017874", "species_113596" ] }, "reaction_10527201": { "compartment": "compartment_70101", "id": "reaction_10527201", "reactome": "R-CEL-508189", "name": "a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29404", "species_508187" ], "products": [ "species_29406", "species_508182" ], "modifiers": [ [ "species_10503361", "catalyst" ] ], "additional_components": [ "CHEBI:28654", "CHEBI:17865", "CHEBI:16530", "CHEBI:57427", "CHEBI:58045", "species_29702", "P54688", "WBGene00001149" ] }, "reaction_10503426": { "compartment": "compartment_5460", "id": "reaction_10503426", "reactome": "R-CEL-70800", "name": "alpha-methylbutyryl-CoA + FAD => tiglyl-CoA + FADH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70718", "species_113596" ], "products": [ "species_70799", "species_31649" ], "modifiers": [ [ "species_10503423", "catalyst" ] ], "additional_components": [ "O44549", "WBGene00019433", "species_113596" ] }, "reaction_10527203": { "compartment": "compartment_5460", "id": "reaction_10527203", "reactome": "R-CEL-508308", "name": "beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O <=> beta-methylcrotonyl-CoA + ATP + CO2 [MCCA]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113548", "species_113581", "species_70772", "species_113521" ], "products": [ "species_70744", "species_29896", "species_113593" ], "modifiers": [ [ "species_10503403", "catalyst" ] ], "additional_components": [ "P34385", "WBGene00303021", "O45430", "WBGene00009319" ] }, "reaction_10503492": { "compartment": "compartment_5460", "id": "reaction_10503492", "reactome": "R-CEL-70893", "name": "methylmalonate semialdehyde + NAD+ + CoA => propionyl-CoA + CO2 + NADH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_113526", "species_30004" ], "products": [ "species_70843", "species_113529", "species_29362", "species_29376" ], "modifiers": [ [ "species_10503489", "catalyst" ] ], "additional_components": [ "WBGene00000114" ] }, "reaction_10556964": { "compartment": "compartment_5460", "id": "reaction_10556964", "reactome": "R-CEL-5693153", "name": "PPM1K dephosphorylates p-BCKDH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10556954", "species_113521" ], "products": [ "species_113548", "species_10503350" ], "modifiers": [ [ "species_10556961", "catalyst" ] ], "additional_components": [ "Q23571", "WBGene00014054", "Q93619", "WBGene00006518", "species_8878387", "O45924", "WBGene00012713", "O17953", "WBGene00010794", "species_113596", "Q23571", "WBGene00014054", "Q93619", "WBGene00006518", "species_8878387", "O45924", "WBGene00012713", "O17953", "WBGene00010794", "species_113596", "species_266099", "G5EEM6", "WBGene00006524" ] }, "reaction_10527205": { "compartment": "compartment_5460", "id": "reaction_10527205", "reactome": "R-CEL-508369", "name": "alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113529", "species_70836", "species_29362" ], "products": [ "species_70829", "species_113526" ], "modifiers": [ [ "species_10503433", "catalyst" ] ], "additional_components": [ "Q19102", "WBGene00000181" ] }, "reaction_10527207": { "compartment": "compartment_5460", "id": "reaction_10527207", "reactome": "R-CEL-508473", "name": "methylmalonyl semialdehyde + NADH + H+ <=> beta-hydroxyisobutyrate + NAD+", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113529", "species_30004", "species_29362" ], "products": [ "species_113526", "species_573404" ], "modifiers": [ [ "species_10503481", "catalyst" ] ], "additional_components": [ "Q9XTI0", "WBGene00007122" ] }, "reaction_10503466": { "compartment": "compartment_5460", "id": "reaction_10503466", "reactome": "R-CEL-70870", "name": "ECHS1 hydrates methacrylyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70858", "species_113521" ], "products": [ "species_71847" ], "modifiers": [ [ "species_10503463", "catalyst" ] ], "additional_components": [ "P34559", "WBGene00001155" ] }, "reaction_10503474": { "compartment": "compartment_5460", "id": "reaction_10503474", "reactome": "R-CEL-70881", "name": "beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71847", "species_113521" ], "products": [ "species_29374", "species_573404" ], "modifiers": [ [ "species_10503471", "catalyst" ] ], "additional_components": [ "WBGene00017301" ] }, "reaction_10503380": { "compartment": "compartment_5460", "id": "reaction_10503380", "reactome": "R-CEL-70724", "name": "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113594", "species_508190" ], "products": [ "species_508181", "species_113552" ], "modifiers": [ [ "species_10503377", "catalyst" ] ], "additional_components": [ "CHEBI:58045", "species_29702", "CHEBI:57427", "CHEBI:16530", "CHEBI:28654", "CHEBI:17865", "P54688", "WBGene00001149", "Q9XXD8", "WBGene00012855" ] }, "reaction_10503446": { "compartment": "compartment_5460", "id": "reaction_10503446", "reactome": "R-CEL-70844", "name": "alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_70836" ], "products": [ "species_70843", "species_113559" ], "modifiers": [ [ "species_10503443", "catalyst" ] ], "additional_components": [ "Q22100", "WBGene00002183" ] }, "reaction_10503416": { "compartment": "compartment_5460", "id": "reaction_10503416", "reactome": "R-CEL-70785", "name": "beta-methylglutaconyl-CoA + H2O <=> beta-hydroxy-beta-methylglutaryl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70772", "species_113521" ], "products": [ "species_70784" ], "modifiers": [ [ "species_10503413", "catalyst" ] ], "additional_components": [ "O45106", "WBGene00001154" ] }, "reaction_10503353": { "compartment": "compartment_5460", "id": "reaction_10503353", "reactome": "R-CEL-70713", "name": "BCKDH transfers CoA group from CoA-SH to BCAAs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_113526", "species_508181" ], "products": [ "species_29362", "species_508261", "species_29376" ], "modifiers": [ [ "species_10503350", "catalyst" ] ], "additional_components": [ "CHEBI:16530", "CHEBI:28654", "CHEBI:17865", "species_70851", "species_70715", "species_70718", "Q23571", "WBGene00014054", "Q93619", "WBGene00006518", "species_8878387", "O45924", "WBGene00012713", "O17953", "WBGene00010794", "species_113596" ] }, "reaction_10503390": { "compartment": "compartment_5460", "id": "reaction_10503390", "reactome": "R-CEL-70745", "name": "isovaleryl-CoA + FAD => beta-methylcrotonyl-CoA + FADH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113596", "species_70715" ], "products": [ "species_70744", "species_31649" ], "modifiers": [ [ "species_10503387", "catalyst" ] ], "additional_components": [ "G5EEH6", "WBGene00015326", "species_113596" ] }, "reaction_10557989": { "compartment": "compartment_7660", "id": "reaction_10557989", "reactome": "R-CEL-6783238", "name": "OTUB1,(OTUB2) binds TP53, UBE2D1, ESR1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10511537", "species_10557985" ], "products": [ "species_10557987" ], "modifiers": [], "additional_components": [ "P35129", "WBGene00002344", "P91853", "WBGene00006732", "Q17720", "WBGene00006717", "Q9XVR6", "WBGene00007718", "Q9XVR6", "WBGene00007718", "P35129", "WBGene00002344", "P91853", "WBGene00006732", "Q17720", "WBGene00006717" ] }, "reaction_10556681": { "compartment": "compartment_70101", "id": "reaction_10556681", "reactome": "R-CEL-5690843", "name": "OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10556669", "species_10556677" ], "products": [ "species_10556679" ], "modifiers": [], "additional_components": [ "Q9XVR6", "WBGene00007718", "Q9XX98", "WBGene00019185", "O76671", "WBGene00019185", "Q22038", "WBGene00004357", "Q9XX98", "WBGene00019185", "O76671", "WBGene00019185", "Q22038", "WBGene00004357", "Q9XVR6", "WBGene00007718" ] }, "reaction_10566184": { "compartment": "compartment_70101", "id": "reaction_10566184", "reactome": "R-CEL-8865182", "name": "OTUD7A hydrolyses K11diUb", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10566176" ], "products": [ "species_10502375" ], "modifiers": [ [ "species_10566181", "catalyst" ] ], "additional_components": [ "P37165", "WBGene00006725", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "WBGene00021733" ] }, "reaction_10554672": { "compartment": "compartment_70101", "id": "reaction_10554672", "reactome": "R-CEL-5665871", "name": "ADRM1 binds 26S proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502572", "species_10554643" ], "products": [ "species_10554645" ], "modifiers": [], "additional_components": [ "P91477", "WBGene00003950", "Q95PZ7", "WBGene00013435", "Q18115", "WBGene00004459", "O62102", "WBGene00003948", "O17071", "WBGene00004504", "Q10920", "WBGene00016623", "P34286", "WBGene00003952", "Q9XTT9", "WBGene00004506", "Q23449", "WBGene00004468", "Q95005", "WBGene00003925", "P46502", "WBGene00004503", "O61792", "WBGene00004464", "O17586", "WBGene00003922", "O76371", "WBGene00004505", "Q20585", "WBGene00004463", "Q95008", "WBGene00003926", "Q18787", "WBGene00004501", "Q20058", "WBGene00009445", "Q9N599", "WBGene00003924", "O16368", "WBGene00004502", "O61742", "WBGene00004466", "Q09583", "WBGene00003928", "Q966I8", "WBGene00003947", "Q04908", "WBGene00004460", "Q9XUV0", "WBGene00003951", "Q27488", "WBGene00003923", "Q9GZH5", "WBGene00004458", "O44156", "WBGene00003927", "Q22253", "WBGene00004465", "O76577", "WBGene00004467", "P90868", "WBGene00003953", "Q19324", "WBGene00004461", "Q17971", "WBGene00007588", "Q23237", "WBGene00003949", "Q20938", "WBGene00004462", "WBGene00016981", "Q09289", "WBGene00016981", "P91477", "WBGene00003950", "Q95PZ7", "WBGene00013435", "Q18115", "WBGene00004459", "O62102", "WBGene00003948", "O17071", "WBGene00004504", "Q10920", "WBGene00016623", "P34286", "WBGene00003952", "Q9XTT9", "WBGene00004506", "Q23449", "WBGene00004468", "Q95005", "WBGene00003925", "P46502", "WBGene00004503", "O61792", "WBGene00004464", "O17586", "WBGene00003922", "O76371", "WBGene00004505", "Q20585", "WBGene00004463", "Q95008", "WBGene00003926", "Q18787", "WBGene00004501", "Q20058", "WBGene00009445", "Q9N599", "WBGene00003924", "O16368", "WBGene00004502", "O61742", "WBGene00004466", "Q09583", "WBGene00003928", "Q966I8", "WBGene00003947", "Q04908", "WBGene00004460", "Q9XUV0", "WBGene00003951", "Q27488", "WBGene00003923", "Q9GZH5", "WBGene00004458", "O44156", "WBGene00003927", "Q22253", "WBGene00004465", "O76577", "WBGene00004467", "P90868", "WBGene00003953", "Q19324", "WBGene00004461", "Q17971", "WBGene00007588", "Q23237", "WBGene00003949", "Q20938", "WBGene00004462" ] }, "reaction_10554649": { "compartment": "compartment_70101", "id": "reaction_10554649", "reactome": "R-CEL-5665854", "name": "ADRM1:26S proteaseome binds UCHL5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10554638", "species_10554645" ], "products": [ "species_10554647" ], "modifiers": [], "additional_components": [ "WBGene00006724", "Q09289", "WBGene00016981", "P91477", "WBGene00003950", "Q95PZ7", "WBGene00013435", "Q18115", "WBGene00004459", "O62102", "WBGene00003948", "O17071", "WBGene00004504", "Q10920", "WBGene00016623", "P34286", "WBGene00003952", "Q9XTT9", "WBGene00004506", "Q23449", "WBGene00004468", "Q95005", "WBGene00003925", "P46502", "WBGene00004503", "O61792", "WBGene00004464", "O17586", "WBGene00003922", "O76371", "WBGene00004505", "Q20585", "WBGene00004463", "Q95008", "WBGene00003926", "Q18787", "WBGene00004501", "Q20058", "WBGene00009445", "Q9N599", "WBGene00003924", "O16368", "WBGene00004502", "O61742", "WBGene00004466", "Q09583", "WBGene00003928", "Q966I8", "WBGene00003947", "Q04908", "WBGene00004460", "Q9XUV0", "WBGene00003951", "Q27488", "WBGene00003923", "Q9GZH5", "WBGene00004458", "O44156", "WBGene00003927", "Q22253", "WBGene00004465", "O76577", "WBGene00004467", "P90868", "WBGene00003953", "Q19324", "WBGene00004461", "Q17971", "WBGene00007588", "Q23237", "WBGene00003949", "Q20938", "WBGene00004462", "Q09289", "WBGene00016981", "P91477", "WBGene00003950", "Q95PZ7", "WBGene00013435", "Q18115", "WBGene00004459", "O62102", "WBGene00003948", "O17071", "WBGene00004504", "Q10920", "WBGene00016623", "P34286", "WBGene00003952", "Q9XTT9", "WBGene00004506", "Q23449", "WBGene00004468", "Q95005", "WBGene00003925", "P46502", "WBGene00004503", "O61792", "WBGene00004464", "O17586", "WBGene00003922", "O76371", "WBGene00004505", "Q20585", "WBGene00004463", "Q95008", "WBGene00003926", "Q18787", "WBGene00004501", "Q20058", "WBGene00009445", "Q9N599", "WBGene00003924", "O16368", "WBGene00004502", "O61742", "WBGene00004466", "Q09583", "WBGene00003928", "Q966I8", "WBGene00003947", "Q04908", "WBGene00004460", "Q9XUV0", "WBGene00003951", "Q27488", "WBGene00003923", "Q9GZH5", "WBGene00004458", "O44156", "WBGene00003927", "Q22253", "WBGene00004465", "O76577", "WBGene00004467", "P90868", "WBGene00003953", "Q19324", "WBGene00004461", "Q17971", "WBGene00007588", "Q23237", "WBGene00003949", "Q20938", "WBGene00004462", "Q09444", "WBGene00006724" ] }, "reaction_10556601": { "compartment": "compartment_70101", "id": "reaction_10556601", "reactome": "R-CEL-5690319", "name": "UCHL1, UCHL3 cleave ubiquitin adducts", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10556596" ], "products": [ "species_1131871", "species_10556598" ], "modifiers": [ [ "species_10556596", "catalyst" ] ], "additional_components": [ "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "P49632", "WBGene00006728", "Q9UAV3", "WBGene00006721", "Q8MNY0", "WBGene00006722", "Q965V9", "WBGene00006723", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "Q9UAV3", "WBGene00006721", "Q8MNY0", "WBGene00006722", "Q965V9", "WBGene00006723", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "P49632", "WBGene00006728", "Q9UAV3", "WBGene00006721", "Q8MNY0", "WBGene00006722", "Q965V9", "WBGene00006723" ] }, "reaction_10556653": { "compartment": "compartment_70101", "id": "reaction_10556653", "reactome": "R-CEL-5690808", "name": "UCHL3, SENP8 cleave NEDD8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10556644" ], "products": [ "species_10556650", "species_10556648" ], "modifiers": [ [ "species_10556644", "catalyst" ] ], "additional_components": [ "Q93725", "WBGene00003587", "Q9UAV3", "WBGene00006721", "Q86FN3", "WBGene00006738", "WBGene00003587", "Q93725", "WBGene00003587", "Q9UAV3", "WBGene00006721", "Q86FN3", "WBGene00006738", "Q93725", "WBGene00003587", "Q9UAV3", "WBGene00006721", "Q86FN3", "WBGene00006738" ] }, "reaction_10556465": { "compartment": "compartment_7660", "id": "reaction_10556465", "reactome": "R-CEL-5689950", "name": "USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10556179" ], "products": [ "species_10556462", "species_10556185" ], "modifiers": [ [ "species_10556179", "catalyst" ] ], "additional_components": [ "O16850", "WBGene00000912", "G5EE01", "WBGene00000913", "Q7JKC3", "WBGene00010406", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "P49632", "WBGene00006728", "G5EE01", "WBGene00000913", "O16850", "WBGene00000912", "Q7JKC3", "WBGene00010406", "O16850", "WBGene00000912", "G5EE01", "WBGene00000913", "Q7JKC3", "WBGene00010406" ] }, "reaction_10557760": { "compartment": "compartment_7660", "id": "reaction_10557760", "reactome": "R-CEL-5696960", "name": "USP49 deubiquitinates H2B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10557755" ], "products": [ "species_10502318", "species_10557757" ], "modifiers": [ [ "species_10557755", "catalyst" ] ], "additional_components": [ "Q9GRV2", "WBGene00013506", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "Q9GRV2", "WBGene00013506", "Q9GRV2", "WBGene00013506" ] }, "reaction_10557827": { "compartment": "compartment_70101", "id": "reaction_10557827", "reactome": "R-CEL-6781764", "name": "USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10557820", "species_29356" ], "products": [ "species_10502375", "species_10557824" ], "modifiers": [ [ "species_10557820", "catalyst" ] ], "additional_components": [ "Q8WT44", "WBGene00000874", "V6CJY2", "WBGene00019259", "Q02330", "WBGene00004856", "F5GUE5", "WBGene00000910", "P45896", "WBGene00004857", "Q21733", "WBGene00000904", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "Q8WT44", "WBGene00000874", "V6CJY2", "WBGene00019259", "Q21733", "WBGene00000904", "F5GUE5", "WBGene00000910", "P45896", "WBGene00004857", "Q02330", "WBGene00004856", "Q8WT44", "WBGene00000874", "V6CJY2", "WBGene00019259", "Q02330", "WBGene00004856", "F5GUE5", "WBGene00000910", "P45896", "WBGene00004857", "Q21733", "WBGene00000904" ] }, "reaction_10556130": { "compartment": "compartment_70101", "id": "reaction_10556130", "reactome": "R-CEL-5689539", "name": "ADRM1:26S proteaseome binds USP14", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10556126", "species_10554645" ], "products": [ "species_10556128" ], "modifiers": [], "additional_components": [ "WBGene00006856", "Q09289", "WBGene00016981", "P91477", "WBGene00003950", "Q95PZ7", "WBGene00013435", "Q18115", "WBGene00004459", "O62102", "WBGene00003948", "O17071", "WBGene00004504", "Q10920", "WBGene00016623", "P34286", "WBGene00003952", "Q9XTT9", "WBGene00004506", "Q23449", "WBGene00004468", "Q95005", "WBGene00003925", "P46502", "WBGene00004503", "O61792", "WBGene00004464", "O17586", "WBGene00003922", "O76371", "WBGene00004505", "Q20585", "WBGene00004463", "Q95008", "WBGene00003926", "Q18787", "WBGene00004501", "Q20058", "WBGene00009445", "Q9N599", "WBGene00003924", "O16368", "WBGene00004502", "O61742", "WBGene00004466", "Q09583", "WBGene00003928", "Q966I8", "WBGene00003947", "Q04908", "WBGene00004460", "Q9XUV0", "WBGene00003951", "Q27488", "WBGene00003923", "Q9GZH5", "WBGene00004458", "O44156", "WBGene00003927", "Q22253", "WBGene00004465", "O76577", "WBGene00004467", "P90868", "WBGene00003953", "Q19324", "WBGene00004461", "Q17971", "WBGene00007588", "Q23237", "WBGene00003949", "Q20938", "WBGene00004462", "Q09289", "WBGene00016981", "P91477", "WBGene00003950", "Q95PZ7", "WBGene00013435", "Q18115", "WBGene00004459", "O62102", "WBGene00003948", "O17071", "WBGene00004504", "Q10920", "WBGene00016623", "P34286", "WBGene00003952", "Q9XTT9", "WBGene00004506", "Q23449", "WBGene00004468", "Q95005", "WBGene00003925", "P46502", "WBGene00004503", "O61792", "WBGene00004464", "O17586", "WBGene00003922", "O76371", "WBGene00004505", "Q20585", "WBGene00004463", "Q95008", "WBGene00003926", "Q18787", "WBGene00004501", "Q20058", "WBGene00009445", "Q9N599", "WBGene00003924", "O16368", "WBGene00004502", "O61742", "WBGene00004466", "Q09583", "WBGene00003928", "Q966I8", "WBGene00003947", "Q04908", "WBGene00004460", "Q9XUV0", "WBGene00003951", "Q27488", "WBGene00003923", "Q9GZH5", "WBGene00004458", "O44156", "WBGene00003927", "Q22253", "WBGene00004465", "O76577", "WBGene00004467", "P90868", "WBGene00003953", "Q19324", "WBGene00004461", "Q17971", "WBGene00007588", "Q23237", "WBGene00003949", "Q20938", "WBGene00004462", "Q17361", "WBGene00006856" ] }, "reaction_10557670": { "compartment": "compartment_7660", "id": "reaction_10557670", "reactome": "R-CEL-5696605", "name": "USP12, USP26 deubiquitinate AR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10557665" ], "products": [ "species_10556462", "species_10557667" ], "modifiers": [ [ "species_10557665", "catalyst" ] ], "additional_components": [ "P34547", "WBGene00011216", "D9N129", "WBGene00007428", "Q20059", "WBGene00009441", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "P49632", "WBGene00006728", "P34547", "WBGene00011216", "D9N129", "WBGene00007428", "Q20059", "WBGene00009441", "P34547", "WBGene00011216", "D9N129", "WBGene00007428", "Q20059", "WBGene00009441" ] }, "reaction_10557721": { "compartment": "compartment_7660", "id": "reaction_10557721", "reactome": "R-CEL-5696958", "name": "USP44 deubiquitinates CDC20", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10557716" ], "products": [ "species_10556462", "species_10557718" ], "modifiers": [ [ "species_10557716", "catalyst" ] ], "additional_components": [ "Q9GRV2", "WBGene00013506", "Q09373", "WBGene00001511", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "P49632", "WBGene00006728", "Q9GRV2", "WBGene00013506", "Q09373", "WBGene00001511", "Q9GRV2", "WBGene00013506", "Q09373", "WBGene00001511" ] }, "reaction_10557836": { "compartment": "compartment_70101", "id": "reaction_10557836", "reactome": "R-CEL-6781797", "name": "USP19 binds HIF1A,BIRC2,BIRC3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10532174", "species_10557832" ], "products": [ "species_10557834" ], "modifiers": [], "additional_components": [ "WBGene00001851", "WBGene00008441", "G5EBW2", "WBGene00008441", "G5EGD2", "WBGene00001851" ] }, "reaction_10557788": { "compartment": "compartment_7660", "id": "reaction_10557788", "reactome": "R-CEL-5697009", "name": "USP37:RUVLB1:PSMC5 deubiquitinates CCNA1,CCNA2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10557781" ], "products": [ "species_10556462", "species_10557785" ], "modifiers": [ [ "species_10557781", "catalyst" ] ], "additional_components": [ "Q9XTT9", "WBGene00004506", "O17607", "WBGene00007784", "P34638", "WBGene00000863", "Q22319", "WBGene00011591", "Q9U2M5", "WBGene00000870", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "P49632", "WBGene00006728", "Q9XTT9", "WBGene00004506", "O17607", "WBGene00007784", "P34638", "WBGene00000863", "Q22319", "WBGene00011591", "Q9U2M5", "WBGene00000870", "Q9XTT9", "WBGene00004506", "O17607", "WBGene00007784", "P34638", "WBGene00000863", "Q22319", "WBGene00011591", "Q9U2M5", "WBGene00000870" ] }, "reaction_10557678": { "compartment": "compartment_70101", "id": "reaction_10557678", "reactome": "R-CEL-5696627", "name": "CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10557675" ], "products": [ "species_10511035", "species_10511040" ], "modifiers": [ [ "species_10557675", "catalyst" ] ], "additional_components": [ "Q7JMS4", "WBGene00009594", "Q9NAC7", "WBGene00013149", "P37165", "WBGene00006725", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "WBGene00013149", "Q7JMS4", "WBGene00009594", "Q9NAC7", "WBGene00013149" ] }, "reaction_10556096": { "compartment": "compartment_7660", "id": "reaction_10556096", "reactome": "R-CEL-5688834", "name": "ATXN3 binds VCP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10554396", "species_10556072" ], "products": [ "species_10556094" ], "modifiers": [], "additional_components": [ "P54812", "WBGene00008053", "WBGene00006446", "O17850", "WBGene00006446", "P54812", "WBGene00008053" ] }, "reaction_10556092": { "compartment": "compartment_70101", "id": "reaction_10556092", "reactome": "R-CEL-5688797", "name": "ATXN3 family cleave Ub chains", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10511035" ], "products": [ "species_10511035", "species_10511033" ], "modifiers": [ [ "species_10556089", "catalyst" ] ], "additional_components": [ "P37165", "WBGene00006725", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "Q8IAA2", "WBGene00022190", "O17850", "WBGene00006446" ] }, "reaction_10556076": { "compartment": "compartment_7660", "id": "reaction_10556076", "reactome": "R-CEL-5688786", "name": "ATXN3 binds RAD23", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10556072", "species_10556065" ], "products": [ "species_10556074" ], "modifiers": [], "additional_components": [ "WBGene00006446", "WBGene00013924", "Q23451", "WBGene00013924", "O17850", "WBGene00006446" ] }, "reaction_10520355": { "compartment": "compartment_7660", "id": "reaction_10520355", "reactome": "R-CEL-382096", "name": "Formation of NR-NCOR Corepressor Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10517933", "species_10519526" ], "products": [ "species_10520353" ], "modifiers": [], "additional_components": [ "WBGene00001565", "P41830", "WBGene00004786", "Q10902", "WBGene00003601", "Q20765", "WBGene00003606", "Q9XUK7", "WBGene00003675", "G5EDJ0", "WBGene00001400", "Q9XVV3", "WBGene00003657", "Q94407", "WBGene00003638", "Q9XYB7", "WBGene00003607", "G5EFF5", "WBGene00000908", "P41829", "WBGene00003605", "Q9U2R6", "WBGene00003681", "Q3V5L2", "WBGene00022423", "Q19345", "WBGene00003623", "G5ED17", "WBGene00010427", "G5ECR9", "WBGene00006790", "Q17771", "WBGene00003628", "Q9N2W3", "WBGene00022374", "Q18190", "WBGene00016126", "Q9XTJ4", "WBGene00003602", "Q21104", "WBGene00003629", "P41828", "WBGene00003622", "P41830", "WBGene00004786", "Q10902", "WBGene00003601", "Q20765", "WBGene00003606", "Q9XUK7", "WBGene00003675", "G5EDJ0", "WBGene00001400", "Q9XVV3", "WBGene00003657", "Q94407", "WBGene00003638", "Q9XYB7", "WBGene00003607", "G5EFF5", "WBGene00000908", "P41829", "WBGene00003605", "Q9U2R6", "WBGene00003681", "Q3V5L2", "WBGene00022423", "Q19345", "WBGene00003623", "G5ED17", "WBGene00010427", "G5ECR9", "WBGene00006790", "Q17771", "WBGene00003628", "Q9N2W3", "WBGene00022374", "Q18190", "WBGene00016126", "Q9XTJ4", "WBGene00003602", "Q21104", "WBGene00003629", "P41828", "WBGene00003622", "P34333", "WBGene00001565" ] }, "reaction_10564209": { "compartment": "compartment_70101", "id": "reaction_10564209", "reactome": "R-CEL-6814096", "name": "ARL1:GTP binds SCOC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10564205", "species_10564157" ], "products": [ "species_10564207" ], "modifiers": [], "additional_components": [ "WBGene00006802", "Q20758", "WBGene00000187", "species_29438", "Q20758", "WBGene00000187", "species_29438", "A7LPF8", "WBGene00006802" ] }, "reaction_10564165": { "compartment": "compartment_263163", "id": "reaction_10564165", "reactome": "R-CEL-6814086", "name": "ARFRP1 recruits ARL1 to the TGN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10564157", "species_10564149" ], "products": [ "species_10564163" ], "modifiers": [], "additional_components": [ "Q20758", "WBGene00000187", "species_29438", "Q9N3C8", "WBGene00021841", "species_29438", "Q8I7G0", "WBGene00020193", "species_29438", "Q20758", "WBGene00000187", "Q9N3C8", "WBGene00021841", "Q8I7G0", "WBGene00020193" ] }, "reaction_10564037": { "compartment": "compartment_263163", "id": "reaction_10564037", "reactome": "R-CEL-6811429", "name": "RIC1:RGP1 stimulates nucleotide RAB6 nucleotide exchange", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10564028" ], "products": [ "species_29420", "species_10564034" ], "modifiers": [ [ "species_10564028", "catalyst" ] ], "additional_components": [ "P34213", "WBGene00004269", "Q22782", "WBGene00004270", "species_29420", "Q7YWW8", "WBGene00010815", "Q09417", "WBGene00011071", "P34213", "WBGene00004269", "Q22782", "WBGene00004270", "species_29438", "Q7YWW8", "WBGene00010815", "Q09417", "WBGene00011071", "P34213", "WBGene00004269", "Q22782", "WBGene00004270", "species_29420", "Q7YWW8", "WBGene00010815", "Q09417", "WBGene00011071" ] }, "reaction_10564519": { "compartment": "compartment_263163", "id": "reaction_10564519", "reactome": "R-CEL-8847534", "name": "RAB43 hydrolyses GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10564512" ], "products": [ "species_10564516" ], "modifiers": [ [ "species_10564512", "catalyst" ] ], "additional_components": [ "Q9U2D8", "WBGene00012894", "Q9U1W9", "WBGene00004278", "species_29438", "species_29420", "Q9U1W9", "WBGene00004278", "Q9U2D8", "WBGene00012894", "Q9U2D8", "WBGene00012894", "Q9U1W9", "WBGene00004278", "species_29438" ] }, "reaction_10564422": { "compartment": "compartment_263163", "id": "reaction_10564422", "reactome": "R-CEL-6814676", "name": "SNAPs and NSF hexamer bind cis-SNARE at the TGN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10564418", "species_10557345", "species_10557329" ], "products": [ "species_10564420" ], "modifiers": [], "additional_components": [ "O02495", "WBGene00004897", "Q9TY08", "WBGene00022534", "O18230", "WBGene00013302", "Q18921", "WBGene00017016", "Q94392", "WBGene00003818", "Q94392", "WBGene00003818", "Q18921", "WBGene00017016", "O02495", "WBGene00004897", "Q9TY08", "WBGene00022534", "O18230", "WBGene00013302" ] }, "reaction_10564200": { "compartment": "compartment_70101", "id": "reaction_10564200", "reactome": "R-CEL-6814094", "name": "ARL1:GTP binds ARFIP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10564157", "species_10564196" ], "products": [ "species_10564198" ], "modifiers": [], "additional_components": [ "Q20758", "WBGene00000187", "species_29438", "WBGene00010040", "P34445", "WBGene00010040", "Q20758", "WBGene00000187", "species_29438" ] }, "reaction_10564171": { "compartment": "compartment_263163", "id": "reaction_10564171", "reactome": "R-CEL-6814088", "name": "SYS1 binds AcM-ARFRP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10564139", "species_10564169" ], "products": [ "species_10564149" ], "modifiers": [], "additional_components": [ "WBGene00020193", "Q9N3C8", "WBGene00021841", "species_29438", "Q9N3C8", "WBGene00021841", "species_29438", "Q8I7G0", "WBGene00020193" ] }, "reaction_10564523": { "compartment": "compartment_263163", "id": "reaction_10564523", "reactome": "R-CEL-8847537", "name": "RAB43:GTP binds USP8NL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10564510", "species_10564521" ], "products": [ "species_10564512" ], "modifiers": [], "additional_components": [ "Q9U1W9", "WBGene00004278", "species_29438", "WBGene00012894", "Q9U2D8", "WBGene00012894", "Q9U1W9", "WBGene00004278", "species_29438" ] }, "reaction_10564191": { "compartment": "compartment_263163", "id": "reaction_10564191", "reactome": "R-CEL-6814091", "name": "ARL1 recruits TGN Golgin homodimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10564187", "species_10564163" ], "products": [ "species_10564189" ], "modifiers": [], "additional_components": [ "A0A3P6PCP8", "WBGene00010306", "Q18013", "WBGene00002220", "species_29438", "Q20758", "WBGene00000187", "Q9N3C8", "WBGene00021841", "Q8I7G0", "WBGene00020193", "species_29438", "Q20758", "WBGene00000187", "Q9N3C8", "WBGene00021841", "Q8I7G0", "WBGene00020193", "A0A3P6PCP8", "WBGene00010306", "Q18013", "WBGene00002220" ] }, "reaction_10564030": { "compartment": "compartment_263163", "id": "reaction_10564030", "reactome": "R-CEL-6811428", "name": "RIC1:RGP1 recruits RAB6:GDP to the TGN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10563998", "species_10564010" ], "products": [ "species_10564028" ], "modifiers": [], "additional_components": [ "species_29420", "P34213", "WBGene00004269", "Q22782", "WBGene00004270", "Q7YWW8", "WBGene00010815", "Q09417", "WBGene00011071", "P34213", "WBGene00004269", "Q22782", "WBGene00004270", "species_29420", "Q7YWW8", "WBGene00010815", "Q09417", "WBGene00011071" ] }, "reaction_10546544": { "compartment": "compartment_7660", "id": "reaction_10546544", "reactome": "R-CEL-3209159", "name": "Phosphorylated ERF translocates to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546532" ], "products": [ "species_10546542" ], "modifiers": [], "additional_components": [ "A0A4V0IJZ6", "WBGene00304788", "O44138", "WBGene00016798", "A0A4V0IK77", "WBGene00016865", "G5EDL0", "WBGene00002990", "A0A4V0IJZ6", "WBGene00304788", "A0A4V0IK77", "WBGene00016865", "G5EDL0", "WBGene00002990", "O44138", "WBGene00016798" ] }, "reaction_10508244": { "compartment": "compartment_5460", "id": "reaction_10508244", "reactome": "R-CEL-77321", "name": "3-Oxohexanoyl-CoA+CoA-SH<=>Butanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_77320" ], "products": [ "species_77318", "species_113559" ], "modifiers": [ [ "species_10508211", "catalyst" ] ], "additional_components": [ "P34255", "WBGene00015125", "Q9GYT0", "WBGene00020347" ] }, "reaction_10508246": { "compartment": "compartment_5460", "id": "reaction_10508246", "reactome": "R-CEL-77323", "name": "(S)-Hydroxyhexanoyl-CoA+NAD<=>3-Oxohexanoyl-CoA+NADH+H", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77322", "species_113526" ], "products": [ "species_77320", "species_113529", "species_29362" ], "modifiers": [ [ "species_10508194", "catalyst" ] ], "additional_components": [ "P41938", "WBGene00007129" ] }, "reaction_10508248": { "compartment": "compartment_5460", "id": "reaction_10508248", "reactome": "R-CEL-77325", "name": "trans-Hex-2-enoyl-CoA+H2O<=>(S)-Hydroxyhexanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77324", "species_113521" ], "products": [ "species_77322" ], "modifiers": [ [ "species_10503463", "catalyst" ] ], "additional_components": [ "P34559", "WBGene00001155" ] }, "reaction_10557962": { "compartment": "compartment_7660", "id": "reaction_10557962", "reactome": "R-CEL-6782227", "name": "Ligation of newly synthesized repair patch to incised DNA in TC-NER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10557947" ], "products": [ "species_10557960", "species_10556705" ], "modifiers": [ [ "species_10502732", "catalyst" ] ], "additional_components": [ "Q95Y97", "WBGene00019767", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "P90829", "WBGene00008645", "Q19366", "WBGene00008722", "Q21730", "WBGene00011016", "O02115", "WBGene00003955", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "P34409", "WBGene00017696", "Q19826", "WBGene00017830", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "O02092", "WBGene00018391", "Q9GR61", "WBGene00021347", "Q9N3C9", "WBGene00021845", "Q93338", "WBGene00007971", "Q18963", "WBGene00008403", "Q21554", "WBGene00010890", "Q23457", "WBGene00004320", "Q17392", "WBGene00000839", "P34545", "WBGene00000366", "Q23088", "WBGene00022812", "Q7JKC3", "WBGene00010406", "H2KYV0", "WBGene00016115", "P52652", "WBGene00012000", "Q86D18", "WBGene00010011", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q10051", "WBGene00020423", "Q20716", "WBGene00009966", "Q9U1Q7", "WBGene00001258", "Q9U2S6", "WBGene00000889", "P52009", "WBGene00000877", "P52016", "WBGene00000884", "P91175", "WBGene00016837", "Q22139", "WBGene00011411", "Q19826", "WBGene00017830", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "O02092", "WBGene00018391", "Q9GR61", "WBGene00021347", "Q9N3C9", "WBGene00021845", "Q93338", "WBGene00007971", "Q18963", "WBGene00008403", "Q21554", "WBGene00010890", "Q23457", "WBGene00004320", "Q17392", "WBGene00000839", "P34545", "WBGene00000366", "Q23088", "WBGene00022812", "Q7JKC3", "WBGene00010406", "H2KYV0", "WBGene00016115", "P52652", "WBGene00012000", "Q86D18", "WBGene00010011", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q10051", "WBGene00020423", "Q20716", "WBGene00009966", "Q9U1Q7", "WBGene00001258", "Q9U2S6", "WBGene00000889", "P52009", "WBGene00000877", "P52016", "WBGene00000884", "P91175", "WBGene00016837", "Q22139", "WBGene00011411", "Q95Y97", "WBGene00019767", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "P90829", "WBGene00008645", "Q19366", "WBGene00008722", "Q21730", "WBGene00011016", "O02115", "WBGene00003955", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "P34409", "WBGene00017696", "WBGene00002985" ] }, "reaction_10557950": { "compartment": "compartment_7660", "id": "reaction_10557950", "reactome": "R-CEL-6782208", "name": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30555", "species_10557945" ], "products": [ "species_10557947", "species_113541" ], "modifiers": [ [ "species_10557945", "catalyst" ] ], "additional_components": [ "Q95Y97", "WBGene00019767", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "P90829", "WBGene00008645", "Q19366", "WBGene00008722", "Q21730", "WBGene00011016", "O02115", "WBGene00003955", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "P34409", "WBGene00017696", "Q19826", "WBGene00017830", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "O02092", "WBGene00018391", "Q9GR61", "WBGene00021347", "Q9N3C9", "WBGene00021845", "Q93338", "WBGene00007971", "Q18963", "WBGene00008403", "Q21554", "WBGene00010890", "Q23457", "WBGene00004320", "Q17392", "WBGene00000839", "P34545", "WBGene00000366", "Q23088", "WBGene00022812", "Q7JKC3", "WBGene00010406", "H2KYV0", "WBGene00016115", "P52652", "WBGene00012000", "Q86D18", "WBGene00010011", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q10051", "WBGene00020423", "Q20716", "WBGene00009966", "Q9U1Q7", "WBGene00001258", "Q9U2S6", "WBGene00000889", "P52009", "WBGene00000877", "P52016", "WBGene00000884", "P91175", "WBGene00016837", "Q22139", "WBGene00011411", "Q95Y97", "WBGene00019767", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "P90829", "WBGene00008645", "Q19366", "WBGene00008722", "Q21730", "WBGene00011016", "O02115", "WBGene00003955", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "P34409", "WBGene00017696", "Q19826", "WBGene00017830", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "O02092", "WBGene00018391", "Q9GR61", "WBGene00021347", "Q9N3C9", "WBGene00021845", "Q93338", "WBGene00007971", "Q18963", "WBGene00008403", "Q21554", "WBGene00010890", "Q23457", "WBGene00004320", "Q17392", "WBGene00000839", "P34545", "WBGene00000366", "Q23088", "WBGene00022812", "Q7JKC3", "WBGene00010406", "H2KYV0", "WBGene00016115", "P52652", "WBGene00012000", "Q86D18", "WBGene00010011", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q10051", "WBGene00020423", "Q20716", "WBGene00009966", "Q9U1Q7", "WBGene00001258", "Q9U2S6", "WBGene00000889", "P52009", "WBGene00000877", "P52016", "WBGene00000884", "P91175", "WBGene00016837", "Q22139", "WBGene00011411", "Q95Y97", "WBGene00019767", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "P90829", "WBGene00008645", "Q19366", "WBGene00008722", "Q21730", "WBGene00011016", "O02115", "WBGene00003955", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "P34409", "WBGene00017696", "Q19826", "WBGene00017830", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "O02092", "WBGene00018391", "Q9GR61", "WBGene00021347", "Q9N3C9", "WBGene00021845", "Q93338", "WBGene00007971", "Q18963", "WBGene00008403", "Q21554", "WBGene00010890", "Q23457", "WBGene00004320", "Q17392", "WBGene00000839", "P34545", "WBGene00000366", "Q23088", "WBGene00022812", "Q7JKC3", "WBGene00010406", "H2KYV0", "WBGene00016115", "P52652", "WBGene00012000", "Q86D18", "WBGene00010011", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q10051", "WBGene00020423", "Q20716", "WBGene00009966", "Q9U1Q7", "WBGene00001258", "Q9U2S6", "WBGene00000889", "P52009", "WBGene00000877", "P52016", "WBGene00000884", "P91175", "WBGene00016837", "Q22139", "WBGene00011411" ] }, "reaction_10517125": { "compartment": "compartment_7660", "id": "reaction_10517125", "reactome": "R-CEL-212269", "name": "DNMT1,3A,3B:PRC2 methylates cytosine and histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10517106" ], "products": [ "species_77502", "species_10517122" ], "modifiers": [ [ "species_10517106", "catalyst" ] ], "additional_components": [ "P62784", "WBGene00001875", "K7ZUH9", "WBGene00001914", "Q10453", "WBGene00001945", "Q9GYS1", "WBGene00003224", "O17514", "WBGene00003220", "P90916", "WBGene00003036", "P90917", "WBGene00004312", "Q9GYS1", "WBGene00003224", "O17514", "WBGene00003220", "P90916", "WBGene00003036", "P90917", "WBGene00004312", "P62784", "WBGene00001875", "Q10453", "WBGene00001945", "K7ZUH9", "WBGene00001914", "P62784", "WBGene00001875", "K7ZUH9", "WBGene00001914", "Q10453", "WBGene00001945", "Q9GYS1", "WBGene00003224", "O17514", "WBGene00003220", "P90916", "WBGene00003036", "P90917", "WBGene00004312" ] }, "reaction_10568425": { "compartment": "compartment_7660", "id": "reaction_10568425", "reactome": "R-CEL-8938853", "name": "CDK6 binds RUNX1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10568421", "species_10568419" ], "products": [ "species_10568423" ], "modifiers": [], "additional_components": [ "G5EFQ5", "WBGene00004393", "Q95ZL9", "WBGene00000272", "WBGene00000406", "Q9XTR1", "WBGene00000406", "G5EFQ5", "WBGene00004393", "Q95ZL9", "WBGene00000272" ] }, "reaction_10566203": { "compartment": "compartment_7660", "id": "reaction_10566203", "reactome": "R-CEL-8865320", "name": "CBFB binds RUNX1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10566199", "species_10566197" ], "products": [ "species_10566201" ], "modifiers": [], "additional_components": [ "WBGene00004393", "WBGene00000272", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393" ] }, "reaction_10568429": { "compartment": "compartment_7660", "id": "reaction_10568429", "reactome": "R-CEL-8938887", "name": "PML binds RUNX1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546215", "species_10566199" ], "products": [ "species_10568427" ], "modifiers": [], "additional_components": [ "WBGene00006523", "WBGene00004393", "G5EFQ5", "WBGene00004393", "G5ED20", "WBGene00006523" ] }, "reaction_10567459": { "compartment": "compartment_70101", "id": "reaction_10567459", "reactome": "R-CEL-8876312", "name": "SLC5A12 cotransports Na+ with LACT, PYR, NCA from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8876310", "species_74113" ], "products": [ "species_83910", "species_8876304" ], "modifiers": [ [ "species_10567456", "catalyst" ] ], "additional_components": [ "species_113557", "species_29708", "species_8869604", "species_113557", "species_29708", "species_197230", "WBGene00018716" ] }, "reaction_10553973": { "compartment": "compartment_70101", "id": "reaction_10553973", "reactome": "R-CEL-5627802", "name": "SLC26A4 transports I- from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_209785" ], "products": [ "species_209818" ], "modifiers": [ [ "species_10553970", "catalyst" ] ], "additional_components": [ "Q94225", "WBGene00018283", "G5EC30", "WBGene00012259", "G5EEA7", "WBGene00010788", "G5EED0", "WBGene00016945", "G5EFB2", "WBGene00013963", "O17951", "WBGene00010789", "O45016", "WBGene00020914" ] }, "reaction_10522983": { "compartment": "compartment_876", "id": "reaction_10522983", "reactome": "R-CEL-427666", "name": "SLC26A3,6 exchange Cl- for HCO3-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_188972", "species_111627" ], "products": [ "species_425425", "species_352022" ], "modifiers": [ [ "species_10522980", "catalyst" ] ], "additional_components": [ "Q94225", "WBGene00018283", "G5EC30", "WBGene00012259", "G5EEA7", "WBGene00010788", "G5EED0", "WBGene00016945", "G5EFB2", "WBGene00013963", "O17951", "WBGene00010789", "O45016", "WBGene00020914" ] }, "reaction_10522894": { "compartment": "compartment_876", "id": "reaction_10522894", "reactome": "R-CEL-427570", "name": "Group 3 - Selective Cl- transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_188972" ], "products": [ "species_352022" ], "modifiers": [ [ "species_10522891", "catalyst" ] ], "additional_components": [ "G5EDS5", "WBGene00017464", "G5EFB2", "WBGene00013963", "O17951", "WBGene00010789", "O45016", "WBGene00020914", "Q94225", "WBGene00018283", "G5EC30", "WBGene00012259", "G5EEA7", "WBGene00010788", "G5EED0", "WBGene00016945" ] }, "reaction_10521777": { "compartment": "compartment_876", "id": "reaction_10521777", "reactome": "R-CEL-418309", "name": "ATP2B1-4 transport cytosolic Ca2+ to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74016" ], "products": [ "species_74112" ], "modifiers": [ [ "species_10521774", "catalyst" ] ], "additional_components": [ "Q95XP5", "WBGene00003153", "Q9TYP9", "WBGene00019875", "G5EFR6", "WBGene00003151" ] }, "reaction_10522476": { "compartment": "compartment_876", "id": "reaction_10522476", "reactome": "R-CEL-425661", "name": "SLC8A1,2,3 exchange 3Na+ for Ca2+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74016", "species_74113" ], "products": [ "species_83910", "species_74112" ], "modifiers": [ [ "species_10522473", "catalyst" ], [ "species_10504094", "inhibitor" ] ], "additional_components": [ "G5EF08", "WBGene00003566", "H2KYP2", "WBGene00003567", "Q11083", "WBGene00020378", "P04630", "WBGene00000285", "G5EF37", "WBGene00003934", "A0A2C9C3L3", "WBGene00020378", "Q18136", "WBGene00006861", "Q09665", "WBGene00006583", "O02159", "WBGene00020378", "G5EDZ8", "WBGene00000288", "Q94288", "WBGene00000287", "Q09980", "WBGene00017394", "O16305", "WBGene00000552", "G5EEG0", "WBGene00000286" ] }, "reaction_10521789": { "compartment": "compartment_114521", "id": "reaction_10521789", "reactome": "R-CEL-418365", "name": "ATP2A1-3 transport cytosolic Ca2+ to dense tubular network lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_427899", "species_74016" ], "products": [ "species_70106", "species_139827" ], "modifiers": [ [ "species_10521782", "catalyst" ] ], "additional_components": [ "WBGene00004736" ] }, "reaction_10521026": { "compartment": "compartment_70101", "id": "reaction_10521026", "reactome": "R-CEL-392195", "name": "Gi activation by P2Y purinoceptor 12", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10521021" ], "products": [ "species_10521023", "species_29420" ], "modifiers": [ [ "species_10521021", "catalyst" ] ], "additional_components": [ "species_29420", "O76584", "WBGene00001673", "Q9BIG5", "WBGene00001666", "Q21917", "WBGene00001669", "P91907", "WBGene00001677", "Q93743", "WBGene00001668", "Q20907", "WBGene00001670", "Q9BIG2", "WBGene00001676", "Q20910", "WBGene00001671", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "species_113582", "species_113582", "species_29438", "O76584", "WBGene00001673", "Q9BIG5", "WBGene00001666", "Q21917", "WBGene00001669", "P91907", "WBGene00001677", "Q93743", "WBGene00001668", "Q20907", "WBGene00001670", "Q9BIG2", "WBGene00001676", "Q20910", "WBGene00001671", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "species_29420", "O76584", "WBGene00001673", "Q9BIG5", "WBGene00001666", "Q21917", "WBGene00001669", "P91907", "WBGene00001677", "Q93743", "WBGene00001668", "Q20907", "WBGene00001670", "Q9BIG2", "WBGene00001676", "Q20910", "WBGene00001671", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "species_113582" ] }, "reaction_10516882": { "compartment": "compartment_7660", "id": "reaction_10516882", "reactome": "R-CEL-211178", "name": "Phosphorylated FOXO1A is excluded from the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10514285" ], "products": [ "species_10516880" ], "modifiers": [], "additional_components": [ "WBGene00000912", "WBGene00000912" ] }, "reaction_10516878": { "compartment": "compartment_7660", "id": "reaction_10516878", "reactome": "R-CEL-211164", "name": "AKT phosphorylates FOXO1A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10514274" ], "products": [ "species_113582", "species_10514285" ], "modifiers": [ [ "species_10514266", "catalyst" ] ], "additional_components": [ "WBGene00000912", "WBGene00000912", "G4S4W1", "WBGene00016980", "Q17941", "WBGene00000102", "Q9XTG7", "WBGene00000103" ] }, "reaction_10544176": { "compartment": "compartment_70101", "id": "reaction_10544176", "reactome": "R-CEL-2408524", "name": "Sec is reduced to H2Se by PXLP-K259-SCLY dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5359016", "species_5357697" ], "products": [ "species_5357660", "species_29432", "species_5359011" ], "modifiers": [ [ "species_10544173", "catalyst" ] ], "additional_components": [ "Q19434", "WBGene00017442" ] }, "reaction_10557618": { "compartment": "compartment_5460", "id": "reaction_10557618", "reactome": "R-CEL-5696415", "name": "PXLP-K278-ETNPPL tetramer hydrolyses PETA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5696414", "species_113521" ], "products": [ "species_113548", "species_113532", "species_5693978" ], "modifiers": [ [ "species_10557615", "catalyst" ] ], "additional_components": [ "P91408", "WBGene00020139" ] }, "reaction_10535129": { "compartment": "compartment_12045", "id": "reaction_10535129", "reactome": "R-CEL-1483203", "name": "PA is dephosphorylated to DAG by LPIN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_426755" ], "products": [ "species_29372", "species_1500596" ], "modifiers": [ [ "species_10535126", "catalyst" ] ], "additional_components": [ "species_114632", "Q9XXT5", "WBGene00010425" ] }, "reaction_10535146": { "compartment": "compartment_70101", "id": "reaction_10535146", "reactome": "R-CEL-1483222", "name": "ETA is phosphorylated to PETA by CHK/ETNK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1498751" ], "products": [ "species_29370", "species_428686" ], "modifiers": [ [ "species_10535028", "catalyst" ] ], "additional_components": [ "P46560", "WBGene00000513", "O17610", "WBGene00000509", "Q22820", "WBGene00000515", "P46558", "WBGene00000511", "Q22942", "WBGene00000510", "P46559", "WBGene00000512", "Q9GZF3", "WBGene00000514" ] }, "reaction_10535118": { "compartment": "compartment_12045", "id": "reaction_10535118", "reactome": "R-CEL-1483190", "name": "PETA and CTP are condensed to CDP-ETA by PCY2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428686", "species_110614" ], "products": [ "species_111294", "species_1500603" ], "modifiers": [ [ "species_10535115", "catalyst" ] ], "additional_components": [ "X5LPX5", "WBGene00021352" ] }, "reaction_10534959": { "compartment": "compartment_12045", "id": "reaction_10534959", "reactome": "R-CEL-1482962", "name": "CDP-ETA and DAG are converted to PE by CEPT1/EPT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500603", "species_1500596" ], "products": [ "species_1500581", "species_109395" ], "modifiers": [ [ "species_10534956", "catalyst" ] ], "additional_components": [ "species_114632", "species_266099", "G5EC09", "WBGene00009057", "G5EC25", "WBGene00013024", "O44732", "WBGene00018797" ] }, "reaction_10557283": { "compartment": "compartment_12045", "id": "reaction_10557283", "reactome": "R-CEL-5694413", "name": "SEC4C,D bind GOSR2 and STX5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10515692", "species_10515690", "species_10515696" ], "products": [ "species_10515698" ], "modifiers": [], "additional_components": [ "WBGene00004755", "P41941", "WBGene00007128", "Q20797", "WBGene00006373", "WBGene00004754", "Q9U2Z1", "WBGene00004754", "P41941", "WBGene00007128", "Q20797", "WBGene00006373", "Q19371", "WBGene00004755" ] }, "reaction_10557378": { "compartment": "compartment_12045", "id": "reaction_10557378", "reactome": "R-CEL-5694428", "name": "LMAN family proteins bind glycosylated cargo", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10515814", "species_10515745" ], "products": [ "species_10515816" ], "modifiers": [], "additional_components": [ "A9Z1L1", "WBGene00005648", "Q19651", "WBGene00005649", "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q21810", "WBGene00011102", "P92005", "WBGene00000789", "Q9XWA4", "WBGene00013764", "Q18740", "WBGene00008231", "Q9XXQ7", "WBGene00013764", "G5EGP8", "WBGene00000788", "Q9U2X1", "WBGene00013764", "G5EDE8", "WBGene00002070", "G5EDE8", "WBGene00002070", "A9Z1L1", "WBGene00005648", "Q19651", "WBGene00005649", "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q21810", "WBGene00011102", "P92005", "WBGene00000789", "Q9XWA4", "WBGene00013764", "Q18740", "WBGene00008231", "Q9XXQ7", "WBGene00013764", "G5EGP8", "WBGene00000788", "Q9U2X1", "WBGene00013764" ] }, "reaction_10557287": { "compartment": "compartment_12045", "id": "reaction_10557287", "reactome": "R-CEL-5694415", "name": "SEC24A,B:SEC23A bind SEC22B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10515950", "species_10515624", "species_10515696" ], "products": [ "species_10557285" ], "modifiers": [], "additional_components": [ "WBGene00004756", "WBGene00018853", "WBGene00004754", "Q9U2Z1", "WBGene00004754", "Q94241", "WBGene00018853", "Q23368", "WBGene00004756" ] }, "reaction_10557501": { "compartment": "compartment_12045", "id": "reaction_10557501", "reactome": "R-CEL-5694522", "name": "Inner coat assembly and cargo binding", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10515678", "species_10515818", "species_10515956" ], "products": [ "species_10515820" ], "modifiers": [], "additional_components": [ "Q23445", "WBGene00022678", "species_29438", "Q9U2Z1", "WBGene00004754", "P41941", "WBGene00007128", "Q20797", "WBGene00006373", "Q19371", "WBGene00004755", "G5EDE8", "WBGene00002070", "A9Z1L1", "WBGene00005648", "Q19651", "WBGene00005649", "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q21810", "WBGene00011102", "P92005", "WBGene00000789", "Q9XWA4", "WBGene00013764", "Q18740", "WBGene00008231", "Q9XXQ7", "WBGene00013764", "G5EGP8", "WBGene00000788", "Q9U2X1", "WBGene00013764", "Q22361", "WBGene00011648", "Q10914", "WBGene00001613", "Q21415", "WBGene00001614", "Q8MXV8", "WBGene00001617", "P34299", "WBGene00001612", "Q9U2Z1", "WBGene00004754", "Q19371", "WBGene00004755", "Q23368", "WBGene00004756", "Q23368", "WBGene00004756", "Q19371", "WBGene00004755", "Q9U2Z1", "WBGene00004754", "P41941", "WBGene00007128", "Q20797", "WBGene00006373", "G5EDE8", "WBGene00002070", "A9Z1L1", "WBGene00005648", "Q19651", "WBGene00005649", "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q21810", "WBGene00011102", "P92005", "WBGene00000789", "Q9XWA4", "WBGene00013764", "Q18740", "WBGene00008231", "Q9XXQ7", "WBGene00013764", "G5EGP8", "WBGene00000788", "Q9U2X1", "WBGene00013764", "Q22361", "WBGene00011648", "Q10914", "WBGene00001613", "Q21415", "WBGene00001614", "Q8MXV8", "WBGene00001617", "P34299", "WBGene00001612", "Q23445", "WBGene00022678", "species_29438" ] }, "reaction_10557388": { "compartment": "compartment_12045", "id": "reaction_10557388", "reactome": "R-CEL-5694442", "name": "CNIH2,3 bind GRIA1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10515725", "species_10515703" ], "products": [ "species_10515727" ], "modifiers": [], "additional_components": [ "Q10914", "WBGene00001613", "Q21415", "WBGene00001614", "Q8MXV8", "WBGene00001617", "P34299", "WBGene00001612", "WBGene00011648", "Q22361", "WBGene00011648", "Q10914", "WBGene00001613", "Q21415", "WBGene00001614", "Q8MXV8", "WBGene00001617", "P34299", "WBGene00001612" ] }, "reaction_10557504": { "compartment": "compartment_70101", "id": "reaction_10557504", "reactome": "R-CEL-5694527", "name": "Loss of SAR1B GTPase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10515820" ], "products": [ "species_29372", "species_10515818", "species_10515956", "species_10515940" ], "modifiers": [ [ "species_10515820", "catalyst" ] ], "additional_components": [ "Q23368", "WBGene00004756", "Q19371", "WBGene00004755", "Q9U2Z1", "WBGene00004754", "P41941", "WBGene00007128", "Q20797", "WBGene00006373", "G5EDE8", "WBGene00002070", "A9Z1L1", "WBGene00005648", "Q19651", "WBGene00005649", "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q21810", "WBGene00011102", "P92005", "WBGene00000789", "Q9XWA4", "WBGene00013764", "Q18740", "WBGene00008231", "Q9XXQ7", "WBGene00013764", "G5EGP8", "WBGene00000788", "Q9U2X1", "WBGene00013764", "Q22361", "WBGene00011648", "Q10914", "WBGene00001613", "Q21415", "WBGene00001614", "Q8MXV8", "WBGene00001617", "P34299", "WBGene00001612", "Q23445", "WBGene00022678", "species_29438", "Q9U2Z1", "WBGene00004754", "P41941", "WBGene00007128", "Q20797", "WBGene00006373", "Q19371", "WBGene00004755", "G5EDE8", "WBGene00002070", "A9Z1L1", "WBGene00005648", "Q19651", "WBGene00005649", "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q21810", "WBGene00011102", "P92005", "WBGene00000789", "Q9XWA4", "WBGene00013764", "Q18740", "WBGene00008231", "Q9XXQ7", "WBGene00013764", "G5EGP8", "WBGene00000788", "Q9U2X1", "WBGene00013764", "Q22361", "WBGene00011648", "Q10914", "WBGene00001613", "Q21415", "WBGene00001614", "Q8MXV8", "WBGene00001617", "P34299", "WBGene00001612", "Q9U2Z1", "WBGene00004754", "Q19371", "WBGene00004755", "Q23368", "WBGene00004756", "species_29420", "Q23445", "WBGene00022678", "Q23368", "WBGene00004756", "Q19371", "WBGene00004755", "Q9U2Z1", "WBGene00004754", "P41941", "WBGene00007128", "Q20797", "WBGene00006373", "G5EDE8", "WBGene00002070", "A9Z1L1", "WBGene00005648", "Q19651", "WBGene00005649", "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q21810", "WBGene00011102", "P92005", "WBGene00000789", "Q9XWA4", "WBGene00013764", "Q18740", "WBGene00008231", "Q9XXQ7", "WBGene00013764", "G5EGP8", "WBGene00000788", "Q9U2X1", "WBGene00013764", "Q22361", "WBGene00011648", "Q10914", "WBGene00001613", "Q21415", "WBGene00001614", "Q8MXV8", "WBGene00001617", "P34299", "WBGene00001612", "Q23445", "WBGene00022678", "species_29438" ] }, "reaction_10557376": { "compartment": "compartment_6791047", "id": "reaction_10557376", "reactome": "R-CEL-5694425", "name": "NSF ATPase activity dissociates cis-SNARE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10557371", "species_113592" ], "products": [ "species_10557359", "species_10557357", "species_29372", "species_10557352", "species_10557350", "species_10557367", "species_10557329", "species_10557345" ], "modifiers": [ [ "species_10557371", "catalyst" ] ], "additional_components": [ "Q94392", "WBGene00003818", "Q18921", "WBGene00017016", "G5EEU1", "WBGene00043064", "P41941", "WBGene00007128", "Q20364", "WBGene00009654", "Q20797", "WBGene00006373", "Q94241", "WBGene00018853", "WBGene00006373", "WBGene00009654", "WBGene00007128", "WBGene00043064", "Q94241", "WBGene00018853", "Q94392", "WBGene00003818", "Q18921", "WBGene00017016", "Q94392", "WBGene00003818", "Q18921", "WBGene00017016", "G5EEU1", "WBGene00043064", "P41941", "WBGene00007128", "Q20364", "WBGene00009654", "Q20797", "WBGene00006373", "Q94241", "WBGene00018853" ] }, "reaction_10515938": { "compartment": "compartment_13959", "id": "reaction_10515938", "reactome": "R-CEL-203973", "name": "Vesicle budding", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10515831" ], "products": [ "species_10515935", "species_10515933", "species_29372", "species_10515827", "species_10515648" ], "modifiers": [ [ "species_10515831", "catalyst" ] ], "additional_components": [ "Q94241", "WBGene00018853", "G5EFY6", "WBGene00011338", "Q9N4A7", "WBGene00003806", "H2KZQ8", "WBGene00017419", "P34643", "WBGene00013985", "Q9U1W1", "WBGene00006565", "Q23368", "WBGene00004756", "Q19371", "WBGene00004755", "Q9U2Z1", "WBGene00004754", "P41941", "WBGene00007128", "Q20797", "WBGene00006373", "G5EDE8", "WBGene00002070", "A9Z1L1", "WBGene00005648", "Q19651", "WBGene00005649", "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q21810", "WBGene00011102", "P92005", "WBGene00000789", "Q9XWA4", "WBGene00013764", "Q18740", "WBGene00008231", "Q9XXQ7", "WBGene00013764", "G5EGP8", "WBGene00000788", "Q9U2X1", "WBGene00013764", "Q22361", "WBGene00011648", "Q10914", "WBGene00001613", "Q21415", "WBGene00001614", "Q8MXV8", "WBGene00001617", "P34299", "WBGene00001612", "Q23445", "WBGene00022678", "species_29438", "WBGene00022678", "Q94241", "WBGene00018853", "Q23368", "WBGene00004756", "Q19371", "WBGene00004755", "Q9U2Z1", "WBGene00004754", "Q10914", "WBGene00001613", "Q21415", "WBGene00001614", "Q8MXV8", "WBGene00001617", "P34299", "WBGene00001612", "Q22361", "WBGene00011648", "P41941", "WBGene00007128", "Q20797", "WBGene00006373", "G5EDE8", "WBGene00002070", "Q9U2X1", "WBGene00013764", "Q9XWA4", "WBGene00013764", "Q9XXQ7", "WBGene00013764", "G5EGP8", "WBGene00000788", "P92005", "WBGene00000789", "Q18740", "WBGene00008231", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "A9Z1L1", "WBGene00005648", "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "Q21810", "WBGene00011102", "G5EFY6", "WBGene00011338", "Q9N4A7", "WBGene00003806", "Q9U1W1", "WBGene00006565", "H2KZQ8", "WBGene00017419", "P34643", "WBGene00013985", "Q94241", "WBGene00018853", "G5EFY6", "WBGene00011338", "Q9N4A7", "WBGene00003806", "H2KZQ8", "WBGene00017419", "P34643", "WBGene00013985", "Q9U1W1", "WBGene00006565", "Q23368", "WBGene00004756", "Q19371", "WBGene00004755", "Q9U2Z1", "WBGene00004754", "P41941", "WBGene00007128", "Q20797", "WBGene00006373", "G5EDE8", "WBGene00002070", "A9Z1L1", "WBGene00005648", "Q19651", "WBGene00005649", "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q21810", "WBGene00011102", "P92005", "WBGene00000789", "Q9XWA4", "WBGene00013764", "Q18740", "WBGene00008231", "Q9XXQ7", "WBGene00013764", "G5EGP8", "WBGene00000788", "Q9U2X1", "WBGene00013764", "Q22361", "WBGene00011648", "Q10914", "WBGene00001613", "Q21415", "WBGene00001614", "Q8MXV8", "WBGene00001617", "P34299", "WBGene00001612", "Q23445", "WBGene00022678", "species_29438" ] }, "reaction_10557380": { "compartment": "compartment_13959", "id": "reaction_10557380", "reactome": "R-CEL-5694439", "name": "COPII coat binds TRAPPCII and RAB1:GDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10557214", "species_10557263", "species_10515933" ], "products": [ "species_10557265" ], "modifiers": [], "additional_components": [ "Q9UAQ6", "WBGene00004266", "species_29420", "Q9NA81", "WBGene00013259", "B1GRL5", "WBGene00077643", "G4SNB8", "WBGene00044604", "P34605", "WBGene00014222", "Q93330", "WBGene00007956", "B1V899", "WBGene00022138", "Q9XU81", "WBGene00010699", "O02173", "WBGene00021046", "Q20100", "WBGene00018088", "Q94241", "WBGene00018853", "Q23368", "WBGene00004756", "Q19371", "WBGene00004755", "Q9U2Z1", "WBGene00004754", "Q10914", "WBGene00001613", "Q21415", "WBGene00001614", "Q8MXV8", "WBGene00001617", "P34299", "WBGene00001612", "Q22361", "WBGene00011648", "P41941", "WBGene00007128", "Q20797", "WBGene00006373", "G5EDE8", "WBGene00002070", "Q9U2X1", "WBGene00013764", "Q9XWA4", "WBGene00013764", "Q9XXQ7", "WBGene00013764", "G5EGP8", "WBGene00000788", "P92005", "WBGene00000789", "Q18740", "WBGene00008231", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "A9Z1L1", "WBGene00005648", "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "Q21810", "WBGene00011102", "G5EFY6", "WBGene00011338", "Q9N4A7", "WBGene00003806", "Q94241", "WBGene00018853", "Q23368", "WBGene00004756", "Q19371", "WBGene00004755", "Q9U2Z1", "WBGene00004754", "Q10914", "WBGene00001613", "Q21415", "WBGene00001614", "Q8MXV8", "WBGene00001617", "P34299", "WBGene00001612", "Q22361", "WBGene00011648", "P41941", "WBGene00007128", "Q20797", "WBGene00006373", "G5EDE8", "WBGene00002070", "Q9U2X1", "WBGene00013764", "Q9XWA4", "WBGene00013764", "Q9XXQ7", "WBGene00013764", "G5EGP8", "WBGene00000788", "P92005", "WBGene00000789", "Q18740", "WBGene00008231", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "A9Z1L1", "WBGene00005648", "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "Q21810", "WBGene00011102", "G5EFY6", "WBGene00011338", "Q9N4A7", "WBGene00003806", "Q9NA81", "WBGene00013259", "B1GRL5", "WBGene00077643", "G4SNB8", "WBGene00044604", "P34605", "WBGene00014222", "Q93330", "WBGene00007956", "B1V899", "WBGene00022138", "Q9XU81", "WBGene00010699", "O02173", "WBGene00021046", "Q20100", "WBGene00018088", "Q9UAQ6", "WBGene00004266", "species_29420" ] }, "reaction_10557289": { "compartment": "compartment_12045", "id": "reaction_10557289", "reactome": "R-CEL-5694417", "name": "SEC16 complex binds SAR1B:GTP:SEC23:SEC24", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10515820", "species_10515827", "species_10515648" ], "products": [ "species_10515829" ], "modifiers": [], "additional_components": [ "Q23368", "WBGene00004756", "Q19371", "WBGene00004755", "Q9U2Z1", "WBGene00004754", "P41941", "WBGene00007128", "Q20797", "WBGene00006373", "G5EDE8", "WBGene00002070", "A9Z1L1", "WBGene00005648", "Q19651", "WBGene00005649", "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q21810", "WBGene00011102", "P92005", "WBGene00000789", "Q9XWA4", "WBGene00013764", "Q18740", "WBGene00008231", "Q9XXQ7", "WBGene00013764", "G5EGP8", "WBGene00000788", "Q9U2X1", "WBGene00013764", "Q22361", "WBGene00011648", "Q10914", "WBGene00001613", "Q21415", "WBGene00001614", "Q8MXV8", "WBGene00001617", "P34299", "WBGene00001612", "Q23445", "WBGene00022678", "species_29438", "Q9U1W1", "WBGene00006565", "H2KZQ8", "WBGene00017419", "P34643", "WBGene00013985", "H2KZQ8", "WBGene00017419", "P34643", "WBGene00013985", "Q9U1W1", "WBGene00006565", "Q23368", "WBGene00004756", "Q19371", "WBGene00004755", "Q9U2Z1", "WBGene00004754", "P41941", "WBGene00007128", "Q20797", "WBGene00006373", "G5EDE8", "WBGene00002070", "A9Z1L1", "WBGene00005648", "Q19651", "WBGene00005649", "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q21810", "WBGene00011102", "P92005", "WBGene00000789", "Q9XWA4", "WBGene00013764", "Q18740", "WBGene00008231", "Q9XXQ7", "WBGene00013764", "G5EGP8", "WBGene00000788", "Q9U2X1", "WBGene00013764", "Q22361", "WBGene00011648", "Q10914", "WBGene00001613", "Q21415", "WBGene00001614", "Q8MXV8", "WBGene00001617", "P34299", "WBGene00001612", "Q23445", "WBGene00022678", "species_29438" ] }, "reaction_10515948": { "compartment": "compartment_70101", "id": "reaction_10515948", "reactome": "R-CEL-203977", "name": "SAR1 Activation And Membrane Binding", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10515940" ], "products": [ "species_10515678", "species_29420" ], "modifiers": [ [ "species_10515945", "catalyst" ] ], "additional_components": [ "species_29420", "Q23445", "WBGene00022678", "Q23445", "WBGene00022678", "species_29438", "WBGene00010496" ] }, "reaction_10564493": { "compartment": "compartment_6791047", "id": "reaction_10564493", "reactome": "R-CEL-6814831", "name": "TBC1D20 binds RAB1:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10564489", "species_10563177" ], "products": [ "species_10564491" ], "modifiers": [], "additional_components": [ "WBGene00013196", "Q9UAQ6", "WBGene00004266", "species_29438", "Q9UAQ6", "WBGene00004266", "species_29438", "Q9XWI2", "WBGene00013196" ] }, "reaction_10564496": { "compartment": "compartment_6791047", "id": "reaction_10564496", "reactome": "R-CEL-6814833", "name": "TBC1D20 stimulates GTPase activity of RAB1, resulting in hydrolysis of GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10564491" ], "products": [ "species_10557214", "species_10564489" ], "modifiers": [ [ "species_10564491", "catalyst" ] ], "additional_components": [ "Q9UAQ6", "WBGene00004266", "species_29438", "Q9XWI2", "WBGene00013196", "Q9UAQ6", "WBGene00004266", "species_29420", "WBGene00013196", "Q9UAQ6", "WBGene00004266", "species_29438", "Q9XWI2", "WBGene00013196" ] }, "reaction_10557460": { "compartment": "compartment_6791047", "id": "reaction_10557460", "reactome": "R-CEL-5694446", "name": "BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10557386", "species_10557361" ], "products": [ "species_10557295", "species_10557369", "species_10557302", "species_10557458" ], "modifiers": [], "additional_components": [ "Q94241", "WBGene00018853", "G5EGG0", "WBGene00010713", "Q10914", "WBGene00001613", "Q21415", "WBGene00001614", "Q8MXV8", "WBGene00001617", "P34299", "WBGene00001612", "Q22361", "WBGene00011648", "Q9U2Z1", "WBGene00004754", "P41941", "WBGene00007128", "Q20797", "WBGene00006373", "Q19371", "WBGene00004755", "G5EDE8", "WBGene00002070", "Q9U2X1", "WBGene00013764", "Q9XWA4", "WBGene00013764", "Q9XXQ7", "WBGene00013764", "G5EGP8", "WBGene00000788", "P92005", "WBGene00000789", "Q18740", "WBGene00008231", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "A9Z1L1", "WBGene00005648", "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "Q21810", "WBGene00011102", "Q19989", "WBGene00018017", "Q9N3Y1", "WBGene00021536", "G5EEU1", "WBGene00043064", "P41941", "WBGene00007128", "Q20364", "WBGene00009654", "Q20797", "WBGene00006373", "Q19989", "WBGene00018017", "Q9N3Y1", "WBGene00021536", "G5EEU1", "WBGene00043064", "P41941", "WBGene00007128", "Q20364", "WBGene00009654", "Q20797", "WBGene00006373", "Q94241", "WBGene00018853", "G5EGG0", "WBGene00010713", "Q22361", "WBGene00011648", "P34299", "WBGene00001612", "Q10914", "WBGene00001613", "Q21415", "WBGene00001614", "Q8MXV8", "WBGene00001617", "Q9U2Z1", "WBGene00004754", "P41941", "WBGene00007128", "Q20797", "WBGene00006373", "Q19371", "WBGene00004755", "Q21810", "WBGene00011102", "G5EGP8", "WBGene00000788", "P92005", "WBGene00000789", "Q18740", "WBGene00008231", "Q9U2X1", "WBGene00013764", "Q9XWA4", "WBGene00013764", "Q9XXQ7", "WBGene00013764", "A9Z1L1", "WBGene00005648", "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "G5EDE8", "WBGene00002070" ] }, "reaction_10557272": { "compartment": "compartment_13959", "id": "reaction_10557272", "reactome": "R-CEL-5694409", "name": "Nucleotide exchange on RAB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10557265" ], "products": [ "species_29420", "species_10557269" ], "modifiers": [ [ "species_10557265", "catalyst" ] ], "additional_components": [ "Q94241", "WBGene00018853", "Q23368", "WBGene00004756", "Q19371", "WBGene00004755", "Q9U2Z1", "WBGene00004754", "Q10914", "WBGene00001613", "Q21415", "WBGene00001614", "Q8MXV8", "WBGene00001617", "P34299", "WBGene00001612", "Q22361", "WBGene00011648", "P41941", "WBGene00007128", "Q20797", "WBGene00006373", "G5EDE8", "WBGene00002070", "Q9U2X1", "WBGene00013764", "Q9XWA4", "WBGene00013764", "Q9XXQ7", "WBGene00013764", "G5EGP8", "WBGene00000788", "P92005", "WBGene00000789", "Q18740", "WBGene00008231", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "A9Z1L1", "WBGene00005648", "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "Q21810", "WBGene00011102", "G5EFY6", "WBGene00011338", "Q9N4A7", "WBGene00003806", "Q9NA81", "WBGene00013259", "B1GRL5", "WBGene00077643", "G4SNB8", "WBGene00044604", "P34605", "WBGene00014222", "Q93330", "WBGene00007956", "B1V899", "WBGene00022138", "Q9XU81", "WBGene00010699", "O02173", "WBGene00021046", "Q20100", "WBGene00018088", "Q9UAQ6", "WBGene00004266", "species_29420", "Q9UAQ6", "WBGene00004266", "species_29438", "Q94241", "WBGene00018853", "Q23368", "WBGene00004756", "Q19371", "WBGene00004755", "Q9U2Z1", "WBGene00004754", "Q10914", "WBGene00001613", "Q21415", "WBGene00001614", "Q8MXV8", "WBGene00001617", "P34299", "WBGene00001612", "Q22361", "WBGene00011648", "P41941", "WBGene00007128", "Q20797", "WBGene00006373", "G5EDE8", "WBGene00002070", "Q9U2X1", "WBGene00013764", "Q9XWA4", "WBGene00013764", "Q9XXQ7", "WBGene00013764", "G5EGP8", "WBGene00000788", "P92005", "WBGene00000789", "Q18740", "WBGene00008231", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "A9Z1L1", "WBGene00005648", "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "Q21810", "WBGene00011102", "G5EFY6", "WBGene00011338", "Q9N4A7", "WBGene00003806", "Q9NA81", "WBGene00013259", "B1GRL5", "WBGene00077643", "G4SNB8", "WBGene00044604", "P34605", "WBGene00014222", "Q93330", "WBGene00007956", "B1V899", "WBGene00022138", "Q9XU81", "WBGene00010699", "O02173", "WBGene00021046", "Q20100", "WBGene00018088", "Q94241", "WBGene00018853", "Q23368", "WBGene00004756", "Q19371", "WBGene00004755", "Q9U2Z1", "WBGene00004754", "Q10914", "WBGene00001613", "Q21415", "WBGene00001614", "Q8MXV8", "WBGene00001617", "P34299", "WBGene00001612", "Q22361", "WBGene00011648", "P41941", "WBGene00007128", "Q20797", "WBGene00006373", "G5EDE8", "WBGene00002070", "Q9U2X1", "WBGene00013764", "Q9XWA4", "WBGene00013764", "Q9XXQ7", "WBGene00013764", "G5EGP8", "WBGene00000788", "P92005", "WBGene00000789", "Q18740", "WBGene00008231", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "A9Z1L1", "WBGene00005648", "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "Q21810", "WBGene00011102", "G5EFY6", "WBGene00011338", "Q9N4A7", "WBGene00003806", "Q9NA81", "WBGene00013259", "B1GRL5", "WBGene00077643", "G4SNB8", "WBGene00044604", "P34605", "WBGene00014222", "Q93330", "WBGene00007956", "B1V899", "WBGene00022138", "Q9XU81", "WBGene00010699", "O02173", "WBGene00021046", "Q20100", "WBGene00018088", "Q9UAQ6", "WBGene00004266", "species_29420" ] }, "reaction_10557373": { "compartment": "compartment_6791047", "id": "reaction_10557373", "reactome": "R-CEL-5694423", "name": "NSF and SNAPs bind cis-SNARE complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10557369", "species_10557345", "species_10557329" ], "products": [ "species_10557371" ], "modifiers": [], "additional_components": [ "G5EEU1", "WBGene00043064", "P41941", "WBGene00007128", "Q20364", "WBGene00009654", "Q20797", "WBGene00006373", "Q94241", "WBGene00018853", "Q18921", "WBGene00017016", "Q94392", "WBGene00003818", "Q94392", "WBGene00003818", "Q18921", "WBGene00017016", "G5EEU1", "WBGene00043064", "P41941", "WBGene00007128", "Q20364", "WBGene00009654", "Q20797", "WBGene00006373", "Q94241", "WBGene00018853" ] }, "reaction_10557310": { "compartment": "compartment_20699", "id": "reaction_10557310", "reactome": "R-CEL-5694418", "name": "RAB1:GTP binds USO1 and GORASP1:GOLGA2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10557295", "species_10557302", "species_10557269" ], "products": [ "species_10557308" ], "modifiers": [], "additional_components": [ "Q19989", "WBGene00018017", "Q9N3Y1", "WBGene00021536", "G5EGG0", "WBGene00010713", "Q9UAQ6", "WBGene00004266", "species_29438", "Q94241", "WBGene00018853", "Q23368", "WBGene00004756", "Q19371", "WBGene00004755", "Q9U2Z1", "WBGene00004754", "Q10914", "WBGene00001613", "Q21415", "WBGene00001614", "Q8MXV8", "WBGene00001617", "P34299", "WBGene00001612", "Q22361", "WBGene00011648", "P41941", "WBGene00007128", "Q20797", "WBGene00006373", "G5EDE8", "WBGene00002070", "Q9U2X1", "WBGene00013764", "Q9XWA4", "WBGene00013764", "Q9XXQ7", "WBGene00013764", "G5EGP8", "WBGene00000788", "P92005", "WBGene00000789", "Q18740", "WBGene00008231", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "A9Z1L1", "WBGene00005648", "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "Q21810", "WBGene00011102", "G5EFY6", "WBGene00011338", "Q9N4A7", "WBGene00003806", "Q9NA81", "WBGene00013259", "B1GRL5", "WBGene00077643", "G4SNB8", "WBGene00044604", "P34605", "WBGene00014222", "Q93330", "WBGene00007956", "B1V899", "WBGene00022138", "Q9XU81", "WBGene00010699", "O02173", "WBGene00021046", "Q20100", "WBGene00018088", "Q9UAQ6", "WBGene00004266", "species_29438", "Q94241", "WBGene00018853", "Q23368", "WBGene00004756", "Q19371", "WBGene00004755", "Q9U2Z1", "WBGene00004754", "Q10914", "WBGene00001613", "Q21415", "WBGene00001614", "Q8MXV8", "WBGene00001617", "P34299", "WBGene00001612", "Q22361", "WBGene00011648", "P41941", "WBGene00007128", "Q20797", "WBGene00006373", "G5EDE8", "WBGene00002070", "Q9U2X1", "WBGene00013764", "Q9XWA4", "WBGene00013764", "Q9XXQ7", "WBGene00013764", "G5EGP8", "WBGene00000788", "P92005", "WBGene00000789", "Q18740", "WBGene00008231", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "A9Z1L1", "WBGene00005648", "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "Q21810", "WBGene00011102", "G5EFY6", "WBGene00011338", "Q9N4A7", "WBGene00003806", "Q9NA81", "WBGene00013259", "B1GRL5", "WBGene00077643", "G4SNB8", "WBGene00044604", "P34605", "WBGene00014222", "Q93330", "WBGene00007956", "B1V899", "WBGene00022138", "Q9XU81", "WBGene00010699", "O02173", "WBGene00021046", "Q20100", "WBGene00018088", "G5EGG0", "WBGene00010713", "Q19989", "WBGene00018017", "Q9N3Y1", "WBGene00021536" ] }, "reaction_10521505": { "compartment": "compartment_876", "id": "reaction_10521505", "reactome": "R-CEL-400071", "name": "Alpha-2A,alpha-2C Adrenergic Receptors bind adrenaline or noradrenaline", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_390627", "species_10519747" ], "products": [ "species_10519749" ], "modifiers": [], "additional_components": [ "species_209794", "species_209789", "O02213", "WBGene00004777", "Q19084", "WBGene00017157", "O02213", "WBGene00004777", "Q19084", "WBGene00017157", "species_209794", "species_209789" ] }, "reaction_10521511": { "compartment": "compartment_876", "id": "reaction_10521511", "reactome": "R-CEL-400092", "name": "Alpha-2A,alpha-2C Adrenergic Receptors activate Gi.Go heterotrimeric G proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10521509" ], "products": [ "species_10521501", "species_29420" ], "modifiers": [ [ "species_10519749", "catalyst" ] ], "additional_components": [ "species_29420", "species_29438", "O02213", "WBGene00004777", "Q19084", "WBGene00017157", "species_209794", "species_209789" ] }, "reaction_10521518": { "compartment": "compartment_876", "id": "reaction_10521518", "reactome": "R-CEL-400097", "name": "G-beta:G-gamma inhibits Adenylate cyclase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10521499", "species_10521514" ], "products": [ "species_10521516" ], "modifiers": [], "additional_components": [] }, "reaction_10521503": { "compartment": "compartment_876", "id": "reaction_10521503", "reactome": "R-CEL-400037", "name": "Gi,Go Heterotrimeric G-protein complex dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10521501" ], "products": [ "species_10521499", "species_10521493" ], "modifiers": [], "additional_components": [ "species_29438", "species_29438" ] }, "reaction_10571830": { "compartment": "compartment_17963", "id": "reaction_10571830", "reactome": "R-CEL-9036987", "name": "FUT2 transfers Fuc to Type 1 chains to form H antigen-sec", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9036984", "species_205683" ], "products": [ "species_205689", "species_9037036" ], "modifiers": [ [ "species_10571827", "catalyst" ] ], "additional_components": [ "WBGene00015019" ] }, "reaction_10571804": { "compartment": "compartment_17963", "id": "reaction_10571804", "reactome": "R-CEL-9033949", "name": "FUT1 transfers Fuc to Type 2 chains to form H antigen-RBC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9033790", "species_205683" ], "products": [ "species_205689", "species_9033793" ], "modifiers": [ [ "species_10571801", "catalyst" ] ], "additional_components": [ "WBGene00015019" ] }, "reaction_10563778": { "compartment": "compartment_7660", "id": "reaction_10563778", "reactome": "R-CEL-6810238", "name": "RNA polymerase II binds initiation factors at promoter of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10504431", "species_10563743" ], "products": [ "species_10563741" ], "modifiers": [], "additional_components": [ "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "G5EG49", "WBGene00013998", "G5EG47", "WBGene00010054", "O44625", "WBGene00004136", "Q9NEX2", "WBGene00013736", "Q9TVL3", "WBGene00000410", "P34424", "WBGene00000508", "P34425", "WBGene00000507", "O17869", "WBGene00009650", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "O16991", "WBGene00006648", "Q9XW26", "WBGene00012735", "P91868", "WBGene00001568", "Q17694", "WBGene00015513", "G5EFV5", "WBGene00000408", "Q17957", "WBGene00006397", "Q9GZI6", "WBGene00006387", "Q7YTH5", "WBGene00006390", "G5EF68", "WBGene00006386", "O45784", "WBGene00006391", "Q20361", "WBGene00006395", "P32085", "WBGene00006542", "Q9XW26", "WBGene00012735", "P91868", "WBGene00001568", "Q17694", "WBGene00015513", "G5EG49", "WBGene00013998", "G5EG47", "WBGene00010054", "Q9TVL3", "WBGene00000410", "P34424", "WBGene00000508", "P34425", "WBGene00000507", "O17869", "WBGene00009650", "O44625", "WBGene00004136", "Q9NEX2", "WBGene00013736", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "O16991", "WBGene00006648", "G5EFV5", "WBGene00000408", "Q17957", "WBGene00006397", "Q9GZI6", "WBGene00006387", "Q7YTH5", "WBGene00006390", "G5EF68", "WBGene00006386", "O45784", "WBGene00006391", "Q20361", "WBGene00006395", "P32085", "WBGene00006542", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140" ] }, "reaction_10564498": { "compartment": "compartment_7660", "id": "reaction_10564498", "reactome": "R-CEL-6814885", "name": "CBCAP complex binds 7-methylguanosine cap of snRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10504700", "species_10504346", "species_10564404", "species_10513169" ], "products": [ "species_10564380" ], "modifiers": [], "additional_components": [ "WBGene00017085", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "A5Z2V1", "WBGene00009451", "P34281", "WBGene00015347", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q9N554", "WBGene00021281", "Q22805", "WBGene00020827", "Q9U3K2", "WBGene00008642", "B7WN63", "WBGene00000994", "O01483", "WBGene00015499", "G5EDW9", "WBGene00008361", "H2KML7", "WBGene00013021", "E5QCH1", "WBGene00013877", "Q95ZM2", "WBGene00017608", "W6RQY9", "WBGene00022360", "O18167", "WBGene00012234", "Q17749", "WBGene00015554", "O44500", "WBGene00019822", "Q9U267", "WBGene00013075", "P30641", "WBGene00011143", "species_430042", "G5EG49", "WBGene00013998", "G5EG47", "WBGene00010054", "O44625", "WBGene00004136", "Q9NEX2", "WBGene00013736", "Q9TVL3", "WBGene00000410", "P34424", "WBGene00000508", "P34425", "WBGene00000507", "O17869", "WBGene00009650", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "O16991", "WBGene00006648", "Q9XW26", "WBGene00012735", "P91868", "WBGene00001568", "Q17694", "WBGene00015513", "G5EFV5", "WBGene00000408", "Q17957", "WBGene00006397", "Q9GZI6", "WBGene00006387", "Q7YTH5", "WBGene00006390", "G5EF68", "WBGene00006386", "O45784", "WBGene00006391", "Q20361", "WBGene00006395", "P32085", "WBGene00006542", "WBGene00022192", "A5Z2V1", "WBGene00009451", "P34281", "WBGene00015347", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q9N554", "WBGene00021281", "Q22805", "WBGene00020827", "Q9U3K2", "WBGene00008642", "B7WN63", "WBGene00000994", "O01483", "WBGene00015499", "G5EDW9", "WBGene00008361", "H2KML7", "WBGene00013021", "E5QCH1", "WBGene00013877", "Q95ZM2", "WBGene00017608", "W6RQY9", "WBGene00022360", "O18167", "WBGene00012234", "Q17749", "WBGene00015554", "O44500", "WBGene00019822", "Q9U267", "WBGene00013075", "P30641", "WBGene00011143", "Q9N4E8", "WBGene00022192", "species_430042", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "Q966L5", "WBGene00017085", "G5EG49", "WBGene00013998", "G5EG47", "WBGene00010054", "O44625", "WBGene00004136", "Q9NEX2", "WBGene00013736", "Q9TVL3", "WBGene00000410", "P34424", "WBGene00000508", "P34425", "WBGene00000507", "O17869", "WBGene00009650", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "O16991", "WBGene00006648", "Q9XW26", "WBGene00012735", "P91868", "WBGene00001568", "Q17694", "WBGene00015513", "G5EFV5", "WBGene00000408", "Q17957", "WBGene00006397", "Q9GZI6", "WBGene00006387", "Q7YTH5", "WBGene00006390", "G5EF68", "WBGene00006386", "O45784", "WBGene00006391", "Q20361", "WBGene00006395", "P32085", "WBGene00006542" ] }, "reaction_10564407": { "compartment": "compartment_7660", "id": "reaction_10564407", "reactome": "R-CEL-6814559", "name": "Pre-snRNA is elongated and capped with 7-methylguanosine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29470", "species_29358", "species_113562", "species_10564402", "species_113571" ], "products": [ "species_10564404" ], "modifiers": [ [ "species_10564402", "catalyst" ], [ "species_10564402", "catalyst" ] ], "additional_components": [ "A5Z2V1", "WBGene00009451", "P34281", "WBGene00015347", "Q9N554", "WBGene00021281", "Q22805", "WBGene00020827", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "P16356", "WBGene00000123", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q9U3K2", "WBGene00008642", "B7WN63", "WBGene00000994", "O01483", "WBGene00015499", "G5EDW9", "WBGene00008361", "H2KML7", "WBGene00013021", "E5QCH1", "WBGene00013877", "Q95ZM2", "WBGene00017608", "W6RQY9", "WBGene00022360", 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"WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q9U3K2", "WBGene00008642", "B7WN63", "WBGene00000994", "O01483", "WBGene00015499", "G5EDW9", "WBGene00008361", "H2KML7", "WBGene00013021", "E5QCH1", "WBGene00013877", "Q95ZM2", "WBGene00017608", "W6RQY9", "WBGene00022360", "O18167", "WBGene00012234", "Q17749", "WBGene00015554", "O44500", "WBGene00019822", "Q9U267", "WBGene00013075", "P30641", "WBGene00011143", "G5EG49", "WBGene00013998", "G5EG47", "WBGene00010054", "O44625", "WBGene00004136", "Q9NEX2", "WBGene00013736", "Q9TVL3", "WBGene00000410", "P34424", "WBGene00000508", "P34425", "WBGene00000507", "O17869", "WBGene00009650", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "O16991", "WBGene00006648", "Q9XW26", "WBGene00012735", "P91868", "WBGene00001568", "Q17694", "WBGene00015513", "G5EFV5", "WBGene00000408", "Q17957", "WBGene00006397", "Q9GZI6", "WBGene00006387", "Q7YTH5", "WBGene00006390", "G5EF68", "WBGene00006386", "O45784", "WBGene00006391", "Q20361", "WBGene00006395", "P32085", "WBGene00006542" ] }, "reaction_10563753": { "compartment": "compartment_7660", "id": "reaction_10563753", "reactome": "R-CEL-6810233", "name": "CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10563741" ], "products": [ "species_113582", "species_10563750" ], "modifiers": [ [ "species_10563741", "catalyst" ] ], "additional_components": [ "Q9XW26", "WBGene00012735", "P91868", "WBGene00001568", "Q17694", "WBGene00015513", "G5EG49", "WBGene00013998", "G5EG47", "WBGene00010054", "Q9TVL3", "WBGene00000410", "P34424", "WBGene00000508", "P34425", "WBGene00000507", "O17869", "WBGene00009650", "O44625", "WBGene00004136", "Q9NEX2", "WBGene00013736", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "O16991", "WBGene00006648", "G5EFV5", "WBGene00000408", "Q17957", "WBGene00006397", "Q9GZI6", "WBGene00006387", "Q7YTH5", "WBGene00006390", "G5EF68", "WBGene00006386", "O45784", "WBGene00006391", "Q20361", "WBGene00006395", "P32085", "WBGene00006542", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "P16356", "WBGene00000123", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "G5EG49", "WBGene00013998", "G5EG47", "WBGene00010054", "O44625", "WBGene00004136", "Q9NEX2", "WBGene00013736", "Q9TVL3", "WBGene00000410", "P34424", "WBGene00000508", "P34425", "WBGene00000507", "O17869", "WBGene00009650", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "O16991", "WBGene00006648", "Q9XW26", "WBGene00012735", "P91868", "WBGene00001568", "Q17694", "WBGene00015513", "G5EFV5", "WBGene00000408", "Q17957", "WBGene00006397", "Q9GZI6", "WBGene00006387", "Q7YTH5", "WBGene00006390", "G5EF68", "WBGene00006386", "O45784", "WBGene00006391", "Q20361", "WBGene00006395", "P32085", "WBGene00006542", "Q9XW26", "WBGene00012735", "P91868", "WBGene00001568", "Q17694", "WBGene00015513", "G5EG49", "WBGene00013998", "G5EG47", "WBGene00010054", "Q9TVL3", "WBGene00000410", "P34424", "WBGene00000508", "P34425", "WBGene00000507", "O17869", "WBGene00009650", "O44625", "WBGene00004136", "Q9NEX2", "WBGene00013736", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "O16991", "WBGene00006648", "G5EFV5", "WBGene00000408", "Q17957", "WBGene00006397", "Q9GZI6", "WBGene00006387", "Q7YTH5", "WBGene00006390", "G5EF68", "WBGene00006386", "O45784", "WBGene00006391", "Q20361", "WBGene00006395", "P32085", "WBGene00006542", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140" ] }, "reaction_10564396": { "compartment": "compartment_7660", "id": "reaction_10564396", "reactome": "R-CEL-6814555", "name": "Integrator complex processes the 3' end of snRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10564380" ], "products": [ "species_10564382", "species_10564388" ], "modifiers": [ [ "species_10564380", "catalyst" ], [ "species_10505223", "catalyst" ], [ "species_10564394", "catalyst" ] ], "additional_components": [ "A5Z2V1", "WBGene00009451", "P34281", "WBGene00015347", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q9N554", "WBGene00021281", "Q22805", "WBGene00020827", "Q9U3K2", "WBGene00008642", "B7WN63", "WBGene00000994", "O01483", "WBGene00015499", "G5EDW9", "WBGene00008361", "H2KML7", "WBGene00013021", "E5QCH1", "WBGene00013877", "Q95ZM2", "WBGene00017608", "W6RQY9", "WBGene00022360", "O18167", "WBGene00012234", "Q17749", "WBGene00015554", "O44500", "WBGene00019822", "Q9U267", "WBGene00013075", "P30641", "WBGene00011143", "Q9N4E8", "WBGene00022192", "species_430042", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "Q966L5", "WBGene00017085", "G5EG49", "WBGene00013998", "G5EG47", "WBGene00010054", "O44625", "WBGene00004136", "Q9NEX2", "WBGene00013736", "Q9TVL3", "WBGene00000410", "P34424", "WBGene00000508", "P34425", "WBGene00000507", "O17869", "WBGene00009650", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "O16991", "WBGene00006648", "Q9XW26", "WBGene00012735", "P91868", "WBGene00001568", "Q17694", "WBGene00015513", "G5EFV5", "WBGene00000408", "Q17957", "WBGene00006397", "Q9GZI6", "WBGene00006387", "Q7YTH5", "WBGene00006390", "G5EF68", "WBGene00006386", "O45784", "WBGene00006391", "Q20361", "WBGene00006395", "P32085", "WBGene00006542", "A5Z2V1", "WBGene00009451", "P34281", "WBGene00015347", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", 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"H2KML7", "WBGene00013021", "E5QCH1", "WBGene00013877", "Q95ZM2", "WBGene00017608", "W6RQY9", "WBGene00022360", "O18167", "WBGene00012234", "Q17749", "WBGene00015554", "O44500", "WBGene00019822", "Q9U267", "WBGene00013075", "P30641", "WBGene00011143", "Q9N4E8", "WBGene00022192", "species_430042", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "Q966L5", "WBGene00017085", "G5EG49", "WBGene00013998", "G5EG47", "WBGene00010054", "O44625", "WBGene00004136", "Q9NEX2", "WBGene00013736", "Q9TVL3", "WBGene00000410", "P34424", "WBGene00000508", "P34425", "WBGene00000507", "O17869", "WBGene00009650", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "O16991", "WBGene00006648", "Q9XW26", "WBGene00012735", "P91868", "WBGene00001568", "Q17694", "WBGene00015513", "G5EFV5", "WBGene00000408", "Q17957", "WBGene00006397", "Q9GZI6", "WBGene00006387", "Q7YTH5", "WBGene00006390", "G5EF68", "WBGene00006386", "O45784", "WBGene00006391", "Q20361", "WBGene00006395", "P32085", "WBGene00006542", "WBGene00020092", "WBGene00020480" ] }, "reaction_10548576": { "compartment": "compartment_876", "id": "reaction_10548576", "reactome": "R-CEL-3928591", "name": "EPH:EFN tetramers oligomerise", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10548574", "species_10548572" ], "products": [ "species_10548507" ], "modifiers": [], "additional_components": [ "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "O61460", "WBGene00006868", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "O61460", "WBGene00006868", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "O61460", "WBGene00006868" ] }, "reaction_10548786": { "compartment": "compartment_876", "id": "reaction_10548786", "reactome": "R-CEL-3928646", "name": "EPHAs bind EFNAs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10548447", "species_10548442" ], "products": [ "species_10548465" ], "modifiers": [], "additional_components": [ "WBGene00006868", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "O61460", "WBGene00006868" ] }, "reaction_10549059": { "compartment": "compartment_876", "id": "reaction_10549059", "reactome": "R-CEL-4093342", "name": "SDC2 multimerises", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10549032" ], "products": [ "species_10549057" ], "modifiers": [], "additional_components": [ "WBGene00004749", "P50605", "WBGene00004749" ] }, "reaction_10548585": { "compartment": "compartment_70101", "id": "reaction_10548585", "reactome": "R-CEL-3928592", "name": "p190RhoGEF exchanges GTP for GDP on RHOA, activating it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509486", "species_29438" ], "products": [ "species_29420", "species_10509488" ], "modifiers": [ [ "species_10548582", "catalyst" ] ], "additional_components": [ "Q22038", "WBGene00004357", "species_29420", "Q22038", "WBGene00004357", "species_29438", "A0A0K3AQN0", "WBGene00013682", "O61460", "WBGene00006868", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "Q95YD4", "WBGene00002213" ] }, "reaction_10548714": { "compartment": "compartment_70101", "id": "reaction_10548714", "reactome": "R-CEL-3928620", "name": "PAK1 autophosphorylates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10548701", "species_113592" ], "products": [ "species_29370", "species_10548711" ], "modifiers": [ [ "species_10548701", "catalyst" ] ], "additional_components": [ "Q03206", "ced-10", "species_29438", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "Q03206", "ced-10", "species_29438", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "Q03206", "ced-10", "species_29438", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911" ] }, "reaction_10549035": { "compartment": "compartment_876", "id": "reaction_10549035", "reactome": "R-CEL-4093332", "name": "p-EPHB phosphorylates SDC2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10537380" ], "products": [ "species_29370", "species_10549032" ], "modifiers": [ [ "species_10548561", "catalyst" ] ], "additional_components": [ "WBGene00004749", "WBGene00004749", "O61460", "WBGene00006868", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869" ] }, "reaction_10549038": { "compartment": "compartment_876", "id": "reaction_10549038", "reactome": "R-CEL-4093336", "name": "p-TIAM1 exchanges GTP for GDP on RAC1, activating it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10520575", "species_29438" ], "products": [ "species_29420", "species_10509457" ], "modifiers": [ [ "species_10548757", "catalyst" ] ], "additional_components": [ "species_29420", "Q03206", "ced-10", "species_29438", "Q03206", "ced-10", "O01847", "WBGene00015704", "O61460", "WBGene00006868", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "Q9N3S5", "WBGene00021635", "G5EE56", "WBGene00005077", "G5EGQ9", "WBGene00003774", "species_159549", "G5EEH3", "WBGene00003775", "species_113552" ] }, "reaction_10548784": { "compartment": "compartment_70101", "id": "reaction_10548784", "reactome": "R-CEL-3928645", "name": "EPHB:NMDAR binds TIAM1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10548750", "species_10516084" ], "products": [ "species_10548752" ], "modifiers": [], "additional_components": [ "O61460", "WBGene00006868", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "Q9N3S5", "WBGene00021635", "G5EE56", "WBGene00005077", "G5EGQ9", "WBGene00003774", "species_159549", "G5EEH3", "WBGene00003775", "species_113552", "WBGene00015704", "O01847", "WBGene00015704", "O61460", "WBGene00006868", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "Q9N3S5", "WBGene00021635", "G5EE56", "WBGene00005077", "G5EGQ9", "WBGene00003774", "species_159549", "G5EEH3", "WBGene00003775", "species_113552" ] }, "reaction_10548599": { "compartment": "compartment_876", "id": "reaction_10548599", "reactome": "R-CEL-3928595", "name": "N-WASP binds ARP2/3 and G-actin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10537823", "species_10515381", "species_10548595" ], "products": [ "species_10548597" ], "modifiers": [], "additional_components": [ "P58798", "WBGene00000204", "A0A3P6PCS5", "WBGene00000201", "Q9N4I0", "WBGene00000199", "species_29358", "Q8WTM6", "WBGene00021170", "P53489", "WBGene00000200", "Q9XWV3", "WBGene00000203", "O61861", "WBGene00000205", "P91167", "WBGene00016729", "P0DM41", "WBGene00000063", "P0DM42", "WBGene00000065", "P10984", "WBGene00000064", "P10986", "WBGene00000066", "species_29358", "Q05062", "WBGene00000390", "species_29438", "O61460", "WBGene00006868", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "A0A0K3AS36", "Y116A8C.36d", "species_179856", "Q05062", "WBGene00000390", "species_29438", "O61460", "WBGene00006868", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "A0A0K3AS36", "Y116A8C.36d", "species_179856", "P0DM41", "WBGene00000063", "P0DM42", "WBGene00000065", "P10984", "WBGene00000064", "P10986", "WBGene00000066", "species_29358", "P58798", "WBGene00000204", "A0A3P6PCS5", "WBGene00000201", "Q9N4I0", "WBGene00000199", "Q8WTM6", "WBGene00021170", "P53489", "WBGene00000200", "Q9XWV3", "WBGene00000203", "O61861", "WBGene00000205", "P91167", "WBGene00016729" ] }, "reaction_10548760": { "compartment": "compartment_70101", "id": "reaction_10548760", "reactome": "R-CEL-3928627", "name": "EPHB phosphorylates TIAM1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10548752" ], "products": [ "species_29370", "species_10548757" ], "modifiers": [ [ "species_10548752", "catalyst" ] ], "additional_components": [ "O01847", "WBGene00015704", "O61460", "WBGene00006868", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "Q9N3S5", "WBGene00021635", "G5EE56", "WBGene00005077", "G5EGQ9", "WBGene00003774", "species_159549", "G5EEH3", "WBGene00003775", "species_113552", "O01847", "WBGene00015704", "O61460", "WBGene00006868", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "Q9N3S5", "WBGene00021635", "G5EE56", "WBGene00005077", "G5EGQ9", "WBGene00003774", "species_159549", "G5EEH3", "WBGene00003775", "species_113552", "O01847", "WBGene00015704", "O61460", "WBGene00006868", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "Q9N3S5", "WBGene00021635", "G5EE56", "WBGene00005077", "G5EGQ9", "WBGene00003774", "species_159549", "G5EEH3", "WBGene00003775", "species_113552" ] }, "reaction_10548378": { "compartment": "compartment_876", "id": "reaction_10548378", "reactome": "R-CEL-3928576", "name": "RHOA:GTP binds ROCK, activating it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10521949", "species_10509488" ], "products": [ "species_10521951" ], "modifiers": [], "additional_components": [ "P92199", "WBGene00002694", "Q21025", "WBGene00019087", "Q9XVH4", "WBGene00019087", "Q22038", "WBGene00004357", "species_29438", "Q22038", "WBGene00004357", "species_29438", "P92199", "WBGene00002694", "Q21025", "WBGene00019087", "Q9XVH4", "WBGene00019087" ] }, "reaction_10548603": { "compartment": "compartment_70101", "id": "reaction_10548603", "reactome": "R-CEL-3928598", "name": "Recruitment of p190RhoGEF to p-FAK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10548580", "species_10548578" ], "products": [ "species_10548582" ], "modifiers": [], "additional_components": [ "O61460", "WBGene00006868", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "Q95YD4", "WBGene00002213", "WBGene00013682", "A0A0K3AQN0", "WBGene00013682", "O61460", "WBGene00006868", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "Q95YD4", "WBGene00002213" ] }, "reaction_10548605": { "compartment": "compartment_876", "id": "reaction_10548605", "reactome": "R-CEL-3928601", "name": "CDC42 and PIP2 bind WASL, activating it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179856", "species_10548593" ], "products": [ "species_10548595" ], "modifiers": [], "additional_components": [ "Q05062", "WBGene00000390", "species_29438", "O61460", "WBGene00006868", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "A0A0K3AS36", "Y116A8C.36d", "Q05062", "WBGene00000390", "species_29438", "O61460", "WBGene00006868", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "A0A0K3AS36", "Y116A8C.36d", "species_179856" ] }, "reaction_10548703": { "compartment": "compartment_876", "id": "reaction_10548703", "reactome": "R-CEL-3928619", "name": "PAK1 binds RAC1:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10516065", "species_10520672" ], "products": [ "species_10548701" ], "modifiers": [], "additional_components": [ "Q03206", "ced-10", "species_29438", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "Q03206", "ced-10", "species_29438", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911" ] }, "reaction_10549055": { "compartment": "compartment_876", "id": "reaction_10549055", "reactome": "R-CEL-4093339", "name": "p120-RasGAP activates GTP hydrolysis on RAS, inactivating it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10549048" ], "products": [ "species_29372", "species_10549052" ], "modifiers": [ [ "species_10549048", "catalyst" ] ], "additional_components": [ "O61460", "WBGene00006868", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "P22981", "WBGene00002335", "species_29438", "O61460", "WBGene00006868", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "P22981", "WBGene00002335", "species_29420", "O61460", "WBGene00006868", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "P22981", "WBGene00002335", "species_29438" ] }, "reaction_10548566": { "compartment": "compartment_70101", "id": "reaction_10548566", "reactome": "R-CEL-3928578", "name": "EPH receptors autophosphorylate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10548507", "species_113592" ], "products": [ "species_29370", "species_10548563" ], "modifiers": [ [ "species_10548507", "catalyst" ] ], "additional_components": [ "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "O61460", "WBGene00006868", "O61460", "WBGene00006868", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "O61460", "WBGene00006868" ] }, "reaction_10548601": { "compartment": "compartment_876", "id": "reaction_10548601", "reactome": "R-CEL-3928597", "name": "EPH:EFN dimers tetramerise", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10548574" ], "products": [ "species_10548572" ], "modifiers": [], "additional_components": [ "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "O61460", "WBGene00006868", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "O61460", "WBGene00006868" ] }, "reaction_10548768": { "compartment": "compartment_876", "id": "reaction_10548768", "reactome": "R-CEL-3928633", "name": "bPIX exchanges GTP for GDP on RAC, activating it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10516063", "species_29438", "species_10548718" ], "products": [ "species_114549", "species_10548720" ], "modifiers": [ [ "species_10548718", "catalyst" ] ], "additional_components": [ "species_29420", "Q03206", "ced-10", "Q21430", "WBGene00010776", "O61460", "WBGene00006868", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q95PX0", "WBGene00006410", "Q19467", "WBGene00008805", "Q03206", "ced-10", "species_29438", "Q21430", "WBGene00010776", "O61460", "WBGene00006868", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q95PX0", "WBGene00006410", "Q19467", "WBGene00008805", "Q21430", "WBGene00010776", "O61460", "WBGene00006868", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q95PX0", "WBGene00006410", "Q19467", "WBGene00008805" ] }, "reaction_10548770": { "compartment": "compartment_70101", "id": "reaction_10548770", "reactome": "R-CEL-3928639", "name": "p-EFNB binds GRB4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10518535", "species_10548675" ], "products": [ "species_10548677" ], "modifiers": [], "additional_components": [ "WBGene00006410", "O61460", "WBGene00006868", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "O61460", "WBGene00006868", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q95PX0", "WBGene00006410" ] }, "reaction_10548691": { "compartment": "compartment_70101", "id": "reaction_10548691", "reactome": "R-CEL-3928615", "name": "EFNBs bind SFKs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10548620", "species_10548503" ], "products": [ "species_10548689" ], "modifiers": [], "additional_components": [ "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "O61460", "WBGene00006868", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "O61460", "WBGene00006868", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635" ] }, "reaction_10548739": { "compartment": "compartment_70101", "id": "reaction_10548739", "reactome": "R-CEL-3928625", "name": "PAKs autophosphorylate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10548724" ], "products": [ "species_29370", "species_10548736" ], "modifiers": [ [ "species_10548724", "catalyst" ] ], "additional_components": [ "Q03206", "ced-10", "species_29438", "Q21430", "WBGene00010776", "O61460", "WBGene00006868", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q95PX0", "WBGene00006410", "Q19467", "WBGene00008805", "Q17850", "WBGene00003911", "G5EGQ3", "WBGene00003144", "Q03206", "ced-10", "species_29438", "Q21430", "WBGene00010776", "O61460", "WBGene00006868", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q95PX0", "WBGene00006410", "Q19467", "WBGene00008805", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "Q03206", "ced-10", "species_29438", "Q21430", "WBGene00010776", "O61460", "WBGene00006868", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q95PX0", "WBGene00006410", "Q19467", "WBGene00008805", "Q17850", "WBGene00003911", "G5EGQ3", "WBGene00003144" ] }, "reaction_10548773": { "compartment": "compartment_70101", "id": "reaction_10548773", "reactome": "R-CEL-3928640", "name": "PAKs phosphorylate MLC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10525019", "species_113592" ], "products": [ "species_29370", "species_10524835" ], "modifiers": [ [ "species_10548736", "catalyst" ] ], "additional_components": [ "WBGene00003372", "WBGene00003372", "Q03206", "ced-10", "species_29438", "Q21430", "WBGene00010776", "O61460", "WBGene00006868", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q95PX0", "WBGene00006410", "Q19467", "WBGene00008805", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911" ] }, "reaction_10548775": { "compartment": "compartment_70101", "id": "reaction_10548775", "reactome": "R-CEL-3928641", "name": "PAK binds RAC and bPIX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10548722", "species_10548720" ], "products": [ "species_10548724" ], "modifiers": [], "additional_components": [ "Q17850", "WBGene00003911", "G5EGQ3", "WBGene00003144", "Q03206", "ced-10", "species_29438", "Q21430", "WBGene00010776", "O61460", "WBGene00006868", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q95PX0", "WBGene00006410", "Q19467", "WBGene00008805", "Q03206", "ced-10", "species_29438", "Q21430", "WBGene00010776", "O61460", "WBGene00006868", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q95PX0", "WBGene00006410", "Q19467", "WBGene00008805", "Q17850", "WBGene00003911", "G5EGQ3", "WBGene00003144" ] }, "reaction_10548765": { "compartment": "compartment_70101", "id": "reaction_10548765", "reactome": "R-CEL-3928631", "name": "GIT1 binds bPIX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10548685", "species_10512284" ], "products": [ "species_10548718" ], "modifiers": [], "additional_components": [ "O61460", "WBGene00006868", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q95PX0", "WBGene00006410", "Q19467", "WBGene00008805", "WBGene00010776", "Q21430", "WBGene00010776", "O61460", "WBGene00006868", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q95PX0", "WBGene00006410", "Q19467", "WBGene00008805" ] }, "reaction_10548687": { "compartment": "compartment_70101", "id": "reaction_10548687", "reactome": "R-CEL-3928614", "name": "EFNB:GRB4 binds GIT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10548683", "species_10548677" ], "products": [ "species_10548685" ], "modifiers": [], "additional_components": [ "WBGene00008805", "O61460", "WBGene00006868", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q95PX0", "WBGene00006410", "O61460", "WBGene00006868", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q95PX0", "WBGene00006410", "Q19467", "WBGene00008805" ] }, "reaction_10548716": { "compartment": "compartment_876", "id": "reaction_10548716", "reactome": "R-CEL-3928624", "name": "EPHBs bind EFNBs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10548493", "species_10548491" ], "products": [ "species_10548503" ], "modifiers": [], "additional_components": [ "WBGene00006868", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "O61460", "WBGene00006868" ] }, "reaction_10548796": { "compartment": "compartment_876", "id": "reaction_10548796", "reactome": "R-CEL-3928651", "name": "NGEF exchanges GTP for GDP on RHOA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10509486" ], "products": [ "species_29420", "species_10509488" ], "modifiers": [ [ "species_10548793", "catalyst" ] ], "additional_components": [ "Q22038", "WBGene00004357", "species_29420", "Q22038", "WBGene00004357", "species_29438", "Q965J0", "WBGene00019487", "O44516", "WBGene00001165", "Q19475", "WBGene00001164", "Q9U3M2", "WBGene00001163", "G5EEE7", "WBGene00006869", "O61460", "WBGene00006868", "Q9N3S5", "WBGene00021635", "G5EE56", "WBGene00005077" ] }, "reaction_10573063": { "compartment": "compartment_7660", "id": "reaction_10573063", "reactome": "R-CEL-9671145", "name": "DKC1 binds SHQ1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10510127", "species_10573059" ], "products": [ "species_10573061" ], "modifiers": [], "additional_components": [ "WBGene00010478", "WBGene00021655", "Q9TYM6", "WBGene00021655", "O17919", "WBGene00010478" ] }, "reaction_10528993": { "compartment": "compartment_17963", "id": "reaction_10528993", "reactome": "R-CEL-914012", "name": "GCNTs transfer GlcNAc from UDP-GlcNAc to Core 1 mucins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_914003", "species_10528918" ], "products": [ "species_10528926", "species_205687" ], "modifiers": [ [ "species_10528990", "catalyst" ] ], "additional_components": [ "Q9U2D6", "WBGene00012901", "P34501", "WBGene00010540", "Q9U2D6", "WBGene00012901", "P34501", "WBGene00010540", "G5EEZ8", "WBGene00001640", "G5EBK7", "WBGene00001644", "O02315", "WBGene00001642", "G5ECK8", "WBGene00001626", "Q19730", "WBGene00001643", "G5EDP7", "WBGene00001641" ] }, "reaction_10528675": { "compartment": "compartment_17963", "id": "reaction_10528675", "reactome": "R-CEL-914006", "name": "Addition of galactose to the Tn antigen via an alpha-1,3 linkage forms a Core 8 glycoprotein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10528570", "species_735682" ], "products": [ "species_205687", "species_10528673" ], "modifiers": [], "additional_components": [ "Q9U2D6", "WBGene00012901", "P34501", "WBGene00010540", "Q9U2D6", "WBGene00012901", "P34501", "WBGene00010540" ] }, "reaction_10529014": { "compartment": "compartment_20699", "id": "reaction_10529014", "reactome": "R-CEL-914018", "name": "Addition of GlcNAc to Core 3 forms a Core 4 glycoprotein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_914003", "species_10528693" ], "products": [ "species_205687", "species_10529011" ], "modifiers": [ [ "species_10528960", "catalyst" ] ], "additional_components": [ "Q9U2D6", "WBGene00012901", "P34501", "WBGene00010540", "P34501", "WBGene00010540", "Q9U2D6", "WBGene00012901", "WBGene00001640" ] }, "reaction_10538297": { "compartment": "compartment_20699", "id": "reaction_10538297", "reactome": "R-CEL-1964505", "name": "C1GALT1 transfers Galactose to the Tn antigen forming Core 1 glycoproteins (T antigens)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10528570", "species_735682" ], "products": [ "species_10528918", "species_205687" ], "modifiers": [ [ "species_10538294", "catalyst" ] ], "additional_components": [ "Q9U2D6", "WBGene00012901", "P34501", "WBGene00010540", "Q9U2D6", "WBGene00012901", "P34501", "WBGene00010540", "Q18515", "WBGene00021403", "O44563", "WBGene00044620", "O17053", "WBGene00021403", "Q22900", "WBGene00021403", "O45579", "WBGene00021403", "O17747", "WBGene00021403", "G5ECT3", "WBGene00021403", "P41881", "WBGene00021403", "O18184", "WBGene00021403", "O16535", "WBGene00021403" ] }, "reaction_10528665": { "compartment": "compartment_17963", "id": "reaction_10528665", "reactome": "R-CEL-914005", "name": "Addition of GlcNAc to the Tn antigen via an alpha-1,3 linkage forms a Core 5 glycoprotein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_914003", "species_10528570" ], "products": [ "species_10528663", "species_205687" ], "modifiers": [], "additional_components": [ "Q9U2D6", "WBGene00012901", "P34501", "WBGene00010540", "Q9U2D6", "WBGene00012901", "P34501", "WBGene00010540" ] }, "reaction_10529003": { "compartment": "compartment_17963", "id": "reaction_10529003", "reactome": "R-CEL-914017", "name": "Addition of GalNAc to the Tn antigen via an alpha-1,6 linkage forms a Core 7 glycoprotein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_735700", "species_10528570" ], "products": [ "species_10529001", "species_205687" ], "modifiers": [], "additional_components": [ "Q9U2D6", "WBGene00012901", "P34501", "WBGene00010540", "Q9U2D6", "WBGene00012901", "P34501", "WBGene00010540" ] }, "reaction_10528685": { "compartment": "compartment_17963", "id": "reaction_10528685", "reactome": "R-CEL-914008", "name": "Addition of GlcNAc to the Tn antigen via a beta-1,6 linkage forms a Core 6 glycoprotein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_914003", "species_10528570" ], "products": [ "species_10528683", "species_205687" ], "modifiers": [], "additional_components": [ "Q9U2D6", "WBGene00012901", "P34501", "WBGene00010540", "Q9U2D6", "WBGene00012901", "P34501", "WBGene00010540" ] }, "reaction_10528910": { "compartment": "compartment_20699", "id": "reaction_10528910", "reactome": "R-CEL-914010", "name": "Addition of GlcNAc to the Tn antigen forms a Core 3 glycoprotein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_914003", "species_10528570" ], "products": [ "species_10528693", "species_205687" ], "modifiers": [ [ "species_10528907", "catalyst" ] ], "additional_components": [ "Q9U2D6", "WBGene00012901", "P34501", "WBGene00010540", "Q9U2D6", "WBGene00012901", "P34501", "WBGene00010540", "Q9XU74", "WBGene00011780", "O62163", "WBGene00011780", "H2L0F4", "WBGene00044618", "O62165", "WBGene00011780", "O02231", "WBGene00011780", "O62375", "WBGene00011780", "O02310", "WBGene00011780", "Q20575", "WBGene00011780", "O17750", "WBGene00011780", "Q6QMT2", "WBGene00000267", "O62114", "WBGene00011780", "G5ECA6", "WBGene00011780", "Q8MQG4", "WBGene00011780", "O62115", "WBGene00011780", "G5EDB3", "WBGene00044630" ] }, "reaction_10528639": { "compartment": "compartment_20699", "id": "reaction_10528639", "reactome": "R-CEL-913675", "name": "GALNTs transfer GalNAc from UDP-GalNAc to mucins to form Tn antigens", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_735700", "species_10528562" ], "products": [ "species_10528570", "species_205687" ], "modifiers": [ [ "species_10528636", "catalyst" ] ], "additional_components": [ "P34501", "WBGene00010540", "Q9U2D6", "WBGene00012901", "Q9U2D6", "WBGene00012901", "P34501", "WBGene00010540", "O61397", "WBGene00001632", "Q95ZJ1", "WBGene00001630", "O61394", "WBGene00001631", "P34678", "WBGene00001628", "Q7K755", "WBGene00001636", "Q8I136", "WBGene00001629", "Q9U2C4", "WBGene00012934" ] }, "reaction_10550347": { "compartment": "compartment_12045", "id": "reaction_10550347", "reactome": "R-CEL-5173192", "name": "POFUT2 transfers fucose to TSR domain-containing proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10550339" ], "products": [ "species_10550147" ], "modifiers": [ [ "species_10550344", "catalyst" ] ], "additional_components": [ "Q19305", "WBGene00006893", "Q966Q0", "WBGene00017376", "Q19349", "WBGene00017376", "G5ECS8", "WBGene00000082", "Q19791", "WBGene00001650", "O76840", "WBGene00003242", "G5ECS8", "WBGene00000082", "Q19791", "WBGene00001650", "Q19349", "WBGene00017376", "Q966Q0", "WBGene00017376", "Q19305", "WBGene00006893", "O76840", "WBGene00003242", "WBGene00010757" ] }, "reaction_10550251": { "compartment": "compartment_12045", "id": "reaction_10550251", "reactome": "R-CEL-5173005", "name": "B3GALTL transfers glucose to O-fucosyl-proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_173594", "species_10550147" ], "products": [ "species_158602", "species_10550243" ], "modifiers": [ [ "species_10550248", "catalyst" ] ], "additional_components": [ "G5ECS8", "WBGene00000082", "Q19791", "WBGene00001650", "Q19349", "WBGene00017376", "Q966Q0", "WBGene00017376", "Q19305", "WBGene00006893", "O76840", "WBGene00003242", "Q19349", "WBGene00017376", "Q966Q0", "WBGene00017376", "G5ECS8", "WBGene00000082", "Q19791", "WBGene00001650", "Q19305", "WBGene00006893", "O76840", "WBGene00003242", "WBGene00022576" ] }, "reaction_10532278": { "compartment": "compartment_70101", "id": "reaction_10532278", "reactome": "R-CEL-1236970", "name": "Proteasomal clevage of exogenous antigen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1236719" ], "products": [ "species_8942986", "species_983036" ], "modifiers": [ [ "species_10502572", "catalyst" ] ], "additional_components": [ "P91477", "WBGene00003950", "Q95PZ7", "WBGene00013435", "Q18115", "WBGene00004459", "O62102", "WBGene00003948", "O17071", "WBGene00004504", "Q10920", "WBGene00016623", "P34286", "WBGene00003952", "Q9XTT9", "WBGene00004506", "Q23449", "WBGene00004468", "Q95005", "WBGene00003925", "P46502", "WBGene00004503", "O61792", "WBGene00004464", "O17586", "WBGene00003922", "O76371", "WBGene00004505", "Q20585", "WBGene00004463", "Q95008", "WBGene00003926", "Q18787", "WBGene00004501", "Q20058", "WBGene00009445", "Q9N599", "WBGene00003924", "O16368", "WBGene00004502", "O61742", "WBGene00004466", "Q09583", "WBGene00003928", "Q966I8", "WBGene00003947", "Q04908", "WBGene00004460", "Q9XUV0", "WBGene00003951", "Q27488", "WBGene00003923", "Q9GZH5", "WBGene00004458", "O44156", "WBGene00003927", "Q22253", "WBGene00004465", "O76577", "WBGene00004467", "P90868", "WBGene00003953", "Q19324", "WBGene00004461", "Q17971", "WBGene00007588", "Q23237", "WBGene00003949", "Q20938", "WBGene00004462" ] }, "reaction_10534835": { "compartment": "compartment_12045", "id": "reaction_10534835", "reactome": "R-CEL-1482647", "name": "2-MAG and DAG are transacylated to TAG by PNPLA2/3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1498728", "species_1500596" ], "products": [ "species_76116", "species_1500594" ], "modifiers": [ [ "species_10534832", "catalyst" ] ], "additional_components": [ "Q11186", "WBGene00015484", "Q18948", "WBGene00015241", "Q9N5Z7", "WBGene00015241" ] }, "reaction_10534837": { "compartment": "compartment_12045", "id": "reaction_10534837", "reactome": "R-CEL-1482654", "name": "2-MAG is transacylated to DAG by PNPLA2/3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1498728" ], "products": [ "species_76116", "species_1500596" ], "modifiers": [ [ "species_10534832", "catalyst" ] ], "additional_components": [ "Q11186", "WBGene00015484", "Q18948", "WBGene00015241", "Q9N5Z7", "WBGene00015241" ] }, "reaction_10534887": { "compartment": "compartment_12045", "id": "reaction_10534887", "reactome": "R-CEL-1482811", "name": "DAG is hydrolyzed to 2-MAG by PNPLA2/3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1500596" ], "products": [ "species_1498728", "species_1524021" ], "modifiers": [ [ "species_10534832", "catalyst" ] ], "additional_components": [ "Q11186", "WBGene00015484", "Q18948", "WBGene00015241", "Q9N5Z7", "WBGene00015241" ] }, "reaction_10534873": { "compartment": "compartment_12045", "id": "reaction_10534873", "reactome": "R-CEL-1482777", "name": "TAG is hydrolyzed to DAG by PNPLA2/3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1500594" ], "products": [ "species_1524021", "species_1500596" ], "modifiers": [ [ "species_10534832", "catalyst" ] ], "additional_components": [ "Q11186", "WBGene00015484", "Q18948", "WBGene00015241", "Q9N5Z7", "WBGene00015241" ] }, "reaction_10534923": { "compartment": "compartment_12045", "id": "reaction_10534923", "reactome": "R-CEL-1482889", "name": "DAG is acylated to TAG by DGAT1/2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500578", "species_1500596" ], "products": [ "species_1500594", "species_76194" ], "modifiers": [ [ "species_10534920", "catalyst" ] ], "additional_components": [ "Q9NCE1", "WBGene00010408", "Q9XUW0", "WBGene00010296", "O01881", "WBGene00021818", "Q23067", "WBGene00020910", "Q9N4S3", "WBGene00021818" ] }, "reaction_10557644": { "compartment": "compartment_12045", "id": "reaction_10557644", "reactome": "R-CEL-5696448", "name": "AWAT2 transfers acyl group from acyl-CoA to MAG, forming DAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5696449", "species_6782195" ], "products": [ "species_76194", "species_1500596" ], "modifiers": [ [ "species_10557641", "catalyst" ] ], "additional_components": [ "O01881", "WBGene00021818", "Q23067", "WBGene00020910", "Q9N4S3", "WBGene00021818", "Q9XUW0", "WBGene00010296" ] }, "reaction_10564718": { "compartment": "compartment_12045", "id": "reaction_10564718", "reactome": "R-CEL-8848580", "name": "DGAT2L6,L7P transfer acyl group from acyl-CoA to DAG, forming TAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500578", "species_1500596" ], "products": [ "species_1500594", "species_76194" ], "modifiers": [ [ "species_10564715", "catalyst" ] ], "additional_components": [ "O01881", "WBGene00021818", "Q23067", "WBGene00020910", "Q9N4S3", "WBGene00021818", "Q9XUW0", "WBGene00010296" ] }, "reaction_10517713": { "compartment": "compartment_70101", "id": "reaction_10517713", "reactome": "R-CEL-265295", "name": "Prostaglandin E synthase isomerizes PGH2 to PGE2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_265283" ], "products": [ "species_265287" ], "modifiers": [ [ "species_10517710", "catalyst" ] ], "additional_components": [ "Q21925", "WBGene00011239", "Q23280", "WBGene00022599" ] }, "reaction_10542977": { "compartment": "compartment_70101", "id": "reaction_10542977", "reactome": "R-CEL-2161614", "name": "PGD2 is reduced to 11-epi-PGF2a by AKRIC3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_879629" ], "products": [ "species_29366", "species_2142710" ], "modifiers": [ [ "species_10513233", "catalyst" ] ], "additional_components": [ "P91020", "WBGene00016985", "Q18903", "WBGene00016985", "Q23320", "WBGene00016985" ] }, "reaction_10542982": { "compartment": "compartment_70101", "id": "reaction_10542982", "reactome": "R-CEL-2161701", "name": "PGH2 is isomerised to PGD2 by HPGDS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_265283" ], "products": [ "species_879629" ], "modifiers": [ [ "species_10542979", "catalyst" ] ], "additional_components": [ "Q09607", "WBGene00001784", "species_1655887" ] }, "reaction_10542974": { "compartment": "compartment_70101", "id": "reaction_10542974", "reactome": "R-CEL-2161549", "name": "PGH2 is reduced to PGF2a by AKR1C3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_265283", "species_29364" ], "products": [ "species_29366", "species_879535" ], "modifiers": [ [ "species_10513233", "catalyst" ] ], "additional_components": [ "P91020", "WBGene00016985", "Q18903", "WBGene00016985", "Q23320", "WBGene00016985" ] }, "reaction_10569857": { "compartment": "compartment_70616", "id": "reaction_10569857", "reactome": "R-CEL-8953461", "name": "SMDT1 assists in assembling MCU, MCUB, MICU1, MICU2 (or MICU3) yielding the MCU complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10568878", "species_10568873", "species_10568887", "species_10568868", "species_10568866" ], "products": [ "species_10568889" ], "modifiers": [], "additional_components": [ "WBGene00008980", "WBGene00013462", "Q18874", "WBGene00008345", "WBGene00019296", "WBGene00019296", "Q21121", "WBGene00019296", "Q18874", "WBGene00008345", "Q95PZ2", "WBGene00013462", "Q9U3I4", "WBGene00008980" ] }, "reaction_10568954": { "compartment": "compartment_70616", "id": "reaction_10568954", "reactome": "R-CEL-8949649", "name": "PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10568937" ], "products": [ "species_10568878", "species_10568939", "species_10568933" ], "modifiers": [ [ "species_10568951", "catalyst" ] ], "additional_components": [ "P54813", "WBGene00010842", "Q9N3T5", "WBGene00004978", "species_216785", "Q9BKU4", "WBGene00004014", "P50093", "WBGene00004015", "Q2HQK3", "WBGene00044745", "G5EDB6", "WBGene00021425", "Q9U3I4", "WBGene00008980", "WBGene00008980", "WBGene00008980", "P54813", "WBGene00010842", "Q9N3T5", "WBGene00004978", "species_216785", "Q9BKU4", "WBGene00004014", "P50093", "WBGene00004015", "Q2HQK3", "WBGene00044745", "G5EDB6", "WBGene00021425", "Q95XN2", "WBGene00022159", "Q23295", "WBGene00013880" ] }, "reaction_10568957": { "compartment": "compartment_70616", "id": "reaction_10568957", "reactome": "R-CEL-8949659", "name": "AFG3L2 (m-AAA protease) degrades SMDT1 that is not assembled in MCU", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10568878" ], "products": [], "modifiers": [ [ "species_10568933", "catalyst" ] ], "additional_components": [ "WBGene00008980", "P54813", "WBGene00010842", "Q9N3T5", "WBGene00004978", "species_216785", "Q9BKU4", "WBGene00004014", "P50093", "WBGene00004015", "Q2HQK3", "WBGene00044745", "G5EDB6", "WBGene00021425" ] }, "reaction_10568959": { "compartment": "compartment_70616", "id": "reaction_10568959", "reactome": "R-CEL-8949661", "name": "C2orf47:AFG3L2 binds the transit peptide of SMDT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10568935", "species_10568933" ], "products": [ "species_10568937" ], "modifiers": [], "additional_components": [ "WBGene00008980", "P54813", "WBGene00010842", "Q9N3T5", "WBGene00004978", "species_216785", "Q9BKU4", "WBGene00004014", "P50093", "WBGene00004015", "Q2HQK3", "WBGene00044745", "G5EDB6", "WBGene00021425", "P54813", "WBGene00010842", "Q9N3T5", "WBGene00004978", "species_216785", "Q9BKU4", "WBGene00004014", "P50093", "WBGene00004015", "Q2HQK3", "WBGene00044745", "G5EDB6", "WBGene00021425", "Q9U3I4", "WBGene00008980" ] }, "reaction_10568964": { "compartment": "compartment_70616", "id": "reaction_10568964", "reactome": "R-CEL-8949688", "name": "SLC8B1 (NCLX) exchanges sodium (mitochondrial intermembrane space) for calcium (mitochondrial matrix)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2889072", "species_8949220" ], "products": [ "species_8949232", "species_2889083" ], "modifiers": [ [ "species_10568961", "catalyst" ] ], "additional_components": [ "WBGene00003572" ] }, "reaction_10568892": { "compartment": "compartment_70616", "id": "reaction_10568892", "reactome": "R-CEL-8949178", "name": "MCU translocates calcium from the mitochondrial intermembrane space to the mitochondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8949232" ], "products": [ "species_8949220" ], "modifiers": [ [ "species_10568889", "catalyst" ] ], "additional_components": [ "Q21121", "WBGene00019296", "Q18874", "WBGene00008345", "Q95PZ2", "WBGene00013462", "Q9U3I4", "WBGene00008980" ] }, "reaction_10505728": { "compartment": "compartment_70101", "id": "reaction_10505728", "reactome": "R-CEL-72670", "name": "Formation of eIF2:GDP:eIF2B intermediate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10505724", "species_10505685" ], "products": [ "species_10505726" ], "modifiers": [], "additional_components": [ "G5EFF9", "WBGene00008670", "Q18994", "WBGene00008428", "P34604", "WBGene00014221", "P80361", "WBGene00004090", "Q9XWD5", "WBGene00012950", "species_29420", "Q9BKU3", "WBGene00021351", "Q21230", "WBGene00010560", "Q95XR0", "WBGene00021466", "species_29420", "G5EFF9", "WBGene00008670", "Q18994", "WBGene00008428", "P34604", "WBGene00014221", "P80361", "WBGene00004090", "Q9XWD5", "WBGene00012950", "Q9BKU3", "WBGene00021351", "Q21230", "WBGene00010560", "Q95XR0", "WBGene00021466" ] }, "reaction_10506002": { "compartment": "compartment_70101", "id": "reaction_10506002", "reactome": "R-CEL-72722", "name": "eIF2 activation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10505726" ], "products": [ "species_10505724", "species_29420", "species_10505633" ], "modifiers": [ [ "species_10505724", "catalyst" ] ], "additional_components": [ "species_29420", "G5EFF9", "WBGene00008670", "Q18994", "WBGene00008428", "P34604", "WBGene00014221", "P80361", "WBGene00004090", "Q9XWD5", "WBGene00012950", "Q9BKU3", "WBGene00021351", "Q21230", "WBGene00010560", "Q95XR0", "WBGene00021466", "G5EFF9", "WBGene00008670", "Q18994", "WBGene00008428", "P34604", "WBGene00014221", "P80361", "WBGene00004090", "Q9XWD5", "WBGene00012950", "species_29438", "Q9BKU3", "WBGene00021351", "Q21230", "WBGene00010560", "Q95XR0", "WBGene00021466", "G5EFF9", "WBGene00008670", "Q18994", "WBGene00008428", "P34604", "WBGene00014221", "P80361", "WBGene00004090", "Q9XWD5", "WBGene00012950" ] }, "reaction_10508240": { "compartment": "compartment_5460", "id": "reaction_10508240", "reactome": "R-CEL-77312", "name": "(S)-Hydroxybutanoyl-CoA+NAD<=>Acetoacetyl-CoA+NADH+H", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113526", "species_77251" ], "products": [ "species_73871", "species_113529", "species_29362" ], "modifiers": [ [ "species_10508194", "catalyst" ] ], "additional_components": [ "P41938", "WBGene00007129" ] }, "reaction_10508242": { "compartment": "compartment_5460", "id": "reaction_10508242", "reactome": "R-CEL-77314", "name": "Crotonoyl-CoA+H2O<=>(S)-3-Hydroxybutanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77313", "species_113521" ], "products": [ "species_77251" ], "modifiers": [ [ "species_10503463", "catalyst" ] ], "additional_components": [ "P34559", "WBGene00001155" ] }, "reaction_10552459": { "compartment": "compartment_876", "id": "reaction_10552459", "reactome": "R-CEL-5577234", "name": "KCND tetramer:KCNIP tetramer transport K+ from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10552456", "catalyst" ] ], "additional_components": [ "Q95XD1", "WBGene00022240", "O45313", "WBGene00008307", "A0A4V0IK35", "WBGene00015867", "G5EGM2", "WBGene00008998", "O16638", "WBGene00021116" ] }, "reaction_10571473": { "compartment": "compartment_70101", "id": "reaction_10571473", "reactome": "R-CEL-9018862", "name": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_9022655" ], "products": [ "species_9022660" ], "modifiers": [ [ "species_10517863", "catalyst" ] ], "additional_components": [ "species_216785", "G5EFT4", "WBGene00016589" ] }, "reaction_10571478": { "compartment": "compartment_70101", "id": "reaction_10571478", "reactome": "R-CEL-9018868", "name": "GPX4-2 reduces 18(S)-HpEPE to 18(S)-HEPE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9020583", "species_29450" ], "products": [ "species_29356", "species_9020474", "species_111745" ], "modifiers": [ [ "species_10571475", "catalyst" ] ], "additional_components": [ "WBGene00019846" ] }, "reaction_10521687": { "compartment": "compartment_876", "id": "reaction_10521687", "reactome": "R-CEL-416690", "name": "SEMA4A binds to PLXND1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10521671", "species_10521683" ], "products": [ "species_10521685" ], "modifiers": [], "additional_components": [ "O45657", "WBGene00004048", "U4PRY7", "WBGene00004047", "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "Q95XP4", "WBGene00003111", "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "Q95XP4", "WBGene00003111", "O45657", "WBGene00004048", "U4PRY7", "WBGene00004047" ] }, "reaction_10521675": { "compartment": "compartment_984", "id": "reaction_10521675", "reactome": "R-CEL-416683", "name": "SEMA3E binds to PLXND1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10521671", "species_10521665" ], "products": [ "species_10521673" ], "modifiers": [], "additional_components": [ "O45657", "WBGene00004048", "U4PRY7", "WBGene00004047", "Q17330", "WBGene00004889", "Q95XP4", "WBGene00003111", "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "Q95XP4", "WBGene00003111", "Q9TYS4", "WBGene00004890", "O45657", "WBGene00004048", "U4PRY7", "WBGene00004047" ] }, "reaction_10524174": { "compartment": "compartment_876", "id": "reaction_10524174", "reactome": "R-CEL-434989", "name": "SEMA7A binds to PLXNC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10524170", "species_10524162" ], "products": [ "species_10524172" ], "modifiers": [], "additional_components": [ "Q17330", "WBGene00004889", "Q95XP4", "WBGene00003111", "Q9TYS4", "WBGene00004890", "U4PRY7", "WBGene00004047", "O45657", "WBGene00004048", "U4PRY7", "WBGene00004047", "O45657", "WBGene00004048", "Q17330", "WBGene00004889", "Q95XP4", "WBGene00003111", "Q9TYS4", "WBGene00004890" ] }, "reaction_10508448": { "compartment": "compartment_7660", "id": "reaction_10508448", "reactome": "R-CEL-109638", "name": "Recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10507139", "species_10504433" ], "products": [ "species_10507141" ], "modifiers": [], "additional_components": [ "Q95ZS0", "WBGene00006392", "Q9GZI6", "WBGene00006387", "G5EF68", "WBGene00006386", "O45784", "WBGene00006391", "P32085", "WBGene00006542", "O61707", "WBGene00006385", "Q9NEW8", "WBGene00006389", "Q9TYN3", "WBGene00006383", "Q18265", "WBGene00016173", "Q17957", "WBGene00006397", "E9P861", "WBGene00006384", "Q20361", "WBGene00006395", "G5EGM3", "WBGene00006382", "O44625", "WBGene00004136", "Q9NEX2", "WBGene00013736", "O16991", "WBGene00006648", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q95ZS0", "WBGene00006392", "Q9GZI6", "WBGene00006387", "G5EF68", "WBGene00006386", "O45784", "WBGene00006391", "P32085", "WBGene00006542", "O61707", "WBGene00006385", "Q9NEW8", "WBGene00006389", "Q9TYN3", "WBGene00006383", "Q18265", "WBGene00016173", "Q17957", "WBGene00006397", "E9P861", "WBGene00006384", "Q20361", "WBGene00006395", "G5EGM3", "WBGene00006382", "O44625", "WBGene00004136", "Q9NEX2", "WBGene00013736", "O16991", "WBGene00006648" ] }, "reaction_10508450": { "compartment": "compartment_7660", "id": "reaction_10508450", "reactome": "R-CEL-109639", "name": "Formation of the closed pre-initiation complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10506316", "species_10507143" ], "products": [ "species_10507432" ], "modifiers": [], "additional_components": [ "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "G5EG49", "WBGene00013998", "G5EG47", "WBGene00010054", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q95ZS0", "WBGene00006392", "Q9GZI6", "WBGene00006387", "G5EF68", "WBGene00006386", "O45784", "WBGene00006391", "P32085", "WBGene00006542", "O61707", "WBGene00006385", "Q9NEW8", "WBGene00006389", "Q9TYN3", "WBGene00006383", "Q18265", "WBGene00016173", "Q17957", "WBGene00006397", "E9P861", "WBGene00006384", "Q20361", "WBGene00006395", "G5EGM3", "WBGene00006382", "O44625", "WBGene00004136", "Q9NEX2", "WBGene00013736", "O16991", "WBGene00006648", "G5EG49", "WBGene00013998", "G5EG47", "WBGene00010054", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q95ZS0", "WBGene00006392", "Q9GZI6", "WBGene00006387", "G5EF68", "WBGene00006386", "O45784", "WBGene00006391", "P32085", "WBGene00006542", "O61707", "WBGene00006385", "Q9NEW8", "WBGene00006389", "Q9TYN3", "WBGene00006383", "Q18265", "WBGene00016173", "Q17957", "WBGene00006397", "E9P861", "WBGene00006384", "Q20361", "WBGene00006395", "G5EGM3", "WBGene00006382", "O44625", "WBGene00004136", "Q9NEX2", "WBGene00013736", "O16991", "WBGene00006648", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529" ] }, "reaction_10507145": { "compartment": "compartment_7660", "id": "reaction_10507145", "reactome": "R-CEL-75095", "name": "Binding of TFIIE to the growing preinitiation complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10507141", "species_10506528" ], "products": [ "species_10507143" ], "modifiers": [], "additional_components": [ "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q95ZS0", "WBGene00006392", "Q9GZI6", "WBGene00006387", "G5EF68", "WBGene00006386", "O45784", "WBGene00006391", "P32085", "WBGene00006542", "O61707", "WBGene00006385", "Q9NEW8", "WBGene00006389", "Q9TYN3", "WBGene00006383", "Q18265", "WBGene00016173", "Q17957", "WBGene00006397", "E9P861", "WBGene00006384", "Q20361", "WBGene00006395", "G5EGM3", "WBGene00006382", "O44625", "WBGene00004136", "Q9NEX2", "WBGene00013736", "O16991", "WBGene00006648", "G5EG49", "WBGene00013998", "G5EG47", "WBGene00010054", "G5EG49", "WBGene00013998", "G5EG47", "WBGene00010054", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q95ZS0", "WBGene00006392", "Q9GZI6", "WBGene00006387", "G5EF68", "WBGene00006386", "O45784", "WBGene00006391", "P32085", "WBGene00006542", "O61707", "WBGene00006385", "Q9NEW8", "WBGene00006389", "Q9TYN3", "WBGene00006383", "Q18265", "WBGene00016173", "Q17957", "WBGene00006397", "E9P861", "WBGene00006384", "Q20361", "WBGene00006395", "G5EGM3", "WBGene00006382", "O44625", "WBGene00004136", "Q9NEX2", "WBGene00013736", "O16991", "WBGene00006648" ] }, "reaction_10508444": { "compartment": "compartment_7660", "id": "reaction_10508444", "reactome": "R-CEL-109636", "name": "Recognition and Binding of Core Promoter Elements by TFIID", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109627", "species_10506516" ], "products": [ "species_10507137" ], "modifiers": [], "additional_components": [ "Q95ZS0", "WBGene00006392", "Q9GZI6", "WBGene00006387", "G5EF68", "WBGene00006386", "O45784", "WBGene00006391", "P32085", "WBGene00006542", "O61707", "WBGene00006385", "Q9NEW8", "WBGene00006389", "Q9TYN3", "WBGene00006383", "Q18265", "WBGene00016173", "Q17957", "WBGene00006397", "E9P861", "WBGene00006384", "Q20361", "WBGene00006395", "G5EGM3", "WBGene00006382", "Q95ZS0", "WBGene00006392", "Q9GZI6", "WBGene00006387", "G5EF68", "WBGene00006386", "O45784", "WBGene00006391", "P32085", "WBGene00006542", "O61707", "WBGene00006385", "Q9NEW8", "WBGene00006389", "Q9TYN3", "WBGene00006383", "Q18265", "WBGene00016173", "Q17957", "WBGene00006397", "E9P861", "WBGene00006384", "Q20361", "WBGene00006395", "G5EGM3", "WBGene00006382" ] }, "reaction_10508446": { "compartment": "compartment_7660", "id": "reaction_10508446", "reactome": "R-CEL-109637", "name": "Binding of TFIIA and TFIIB to the pol II promoter:TFIID complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10506438", "species_10506433", "species_10507137" ], "products": [ "species_10507139" ], "modifiers": [], "additional_components": [ "WBGene00006648", "O44625", "WBGene00004136", "Q9NEX2", "WBGene00013736", "Q95ZS0", "WBGene00006392", "Q9GZI6", "WBGene00006387", "G5EF68", "WBGene00006386", "O45784", "WBGene00006391", "P32085", "WBGene00006542", "O61707", "WBGene00006385", "Q9NEW8", "WBGene00006389", "Q9TYN3", "WBGene00006383", "Q18265", "WBGene00016173", "Q17957", "WBGene00006397", "E9P861", "WBGene00006384", "Q20361", "WBGene00006395", "G5EGM3", "WBGene00006382", "Q95ZS0", "WBGene00006392", "Q9GZI6", "WBGene00006387", "G5EF68", "WBGene00006386", "O45784", "WBGene00006391", "P32085", "WBGene00006542", "O61707", "WBGene00006385", "Q9NEW8", "WBGene00006389", "Q9TYN3", "WBGene00006383", "Q18265", "WBGene00016173", "Q17957", "WBGene00006397", "E9P861", "WBGene00006384", "Q20361", "WBGene00006395", "G5EGM3", "WBGene00006382", "O44625", "WBGene00004136", "Q9NEX2", "WBGene00013736", "O16991", "WBGene00006648" ] }, "reaction_10532932": { "compartment": "compartment_876", "id": "reaction_10532932", "reactome": "R-CEL-1299359", "name": "Activation of TALK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10532929", "catalyst" ] ], "additional_components": [ "O45891", "WBGene00006692", "G5ED42", "WBGene00006670", "Q65XY3", "WBGene00019904", "Q18261", "WBGene00016168", "G5EEH1", "WBGene00006693", "Q6BES3", "WBGene00006677", "Q19525", "WBGene00006661", "I2HAD3", "WBGene00006676", "Q93732", "WBGene00006681", "C0Z3L1", "WBGene00001190", "Q23435", "WBGene00006664" ] }, "reaction_10532792": { "compartment": "compartment_876", "id": "reaction_10532792", "reactome": "R-CEL-1296348", "name": "Activation of TWIK-related K+ channel (TREK)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10532789", "catalyst" ] ], "additional_components": [ "G5ECW6", "WBGene00006673", "O17185", "WBGene00006318" ] }, "reaction_10532802": { "compartment": "compartment_876", "id": "reaction_10532802", "reactome": "R-CEL-1299297", "name": "Activation of THIK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10532799", "catalyst" ] ], "additional_components": [ "F5GUD1", "WBGene00006669" ] }, "reaction_10532833": { "compartment": "compartment_876", "id": "reaction_10532833", "reactome": "R-CEL-1299304", "name": "Activation of tandem pore domain in a weak inwardly rectifying K+ channels", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10532830", "catalyst" ] ], "additional_components": [ "Q10937", "WBGene00015137", "Q9NEV3", "WBGene00006696" ] }, "reaction_10532854": { "compartment": "compartment_876", "id": "reaction_10532854", "reactome": "R-CEL-1299318", "name": "Activation of TASK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10532851", "catalyst" ] ], "additional_components": [ "G5ECW6", "WBGene00006673", "O17185", "WBGene00006318" ] }, "reaction_10532864": { "compartment": "compartment_876", "id": "reaction_10532864", "reactome": "R-CEL-1299338", "name": "Activation of TRESK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10532861", "catalyst" ] ], "additional_components": [ "Q22043", "WBGene00006675" ] }, "reaction_10532761": { "compartment": "compartment_876", "id": "reaction_10532761", "reactome": "R-CEL-1296046", "name": "KCNJs transport K+ from the extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74126" ], "products": [ "species_29804" ], "modifiers": [ [ "species_10532758", "catalyst" ] ], "additional_components": [ "P52192", "WBGene00002149", "A0A1C3NSK2", "WBGene00002151", "A0A1C3NSN6", "WBGene00002150" ] }, "reaction_10532746": { "compartment": "compartment_876", "id": "reaction_10532746", "reactome": "R-CEL-1296045", "name": "Activation of Potassium transport channels", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10532743", "catalyst" ] ], "additional_components": [ "P52192", "WBGene00002149", "A0A1C3NSK2", "WBGene00002151", "A0A1C3NSN6", "WBGene00002150" ] }, "reaction_10566209": { "compartment": "compartment_7660", "id": "reaction_10566209", "reactome": "R-CEL-8865454", "name": "CBFB binds RUNX3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10566205", "species_10566197" ], "products": [ "species_10566207" ], "modifiers": [], "additional_components": [ "WBGene00004393", "WBGene00000272", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393" ] }, "reaction_10568338": { "compartment": "compartment_70101", "id": "reaction_10568338", "reactome": "R-CEL-8937792", "name": "RUNX3 binds SRC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10568334", "species_10518187" ], "products": [ "species_10568336" ], "modifiers": [], "additional_components": [ "WBGene00004393", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "G5EFQ5", "WBGene00004393" ] }, "reaction_10569702": { "compartment": "compartment_7660", "id": "reaction_10569702", "reactome": "R-CEL-8952399", "name": "Polyubiquitinated RUNX3 translocates to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10569698" ], "products": [ "species_10569700" ], "modifiers": [], "additional_components": [ "WBGene00004393", "WBGene00004393" ] }, "reaction_10568344": { "compartment": "compartment_70101", "id": "reaction_10568344", "reactome": "R-CEL-8937807", "name": "SRC phosphorylates RUNX3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10568336" ], "products": [ "species_10518187", "species_29370", "species_10568341" ], "modifiers": [ [ "species_10568336", "catalyst" ] ], "additional_components": [ "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "G5EFQ5", "WBGene00004393", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "WBGene00004393", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "G5EFQ5", "WBGene00004393" ] }, "reaction_10569704": { "compartment": "compartment_70101", "id": "reaction_10569704", "reactome": "R-CEL-8952408", "name": "Polyubiquitinated RUNX3 is degraded by the proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10569700" ], "products": [ "species_10502375" ], "modifiers": [ [ "species_10512606", "catalyst" ] ], "additional_components": [ "WBGene00004393", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "Q23237", "WBGene00003949", "P90868", "WBGene00003953", "Q9XUV0", "WBGene00003951", "Q966I8", "WBGene00003947", "O62102", "WBGene00003948", "O16368", "WBGene00004502", "Q18787", "WBGene00004501", "O76371", "WBGene00004505", "P46502", "WBGene00004503", "Q9XTT9", "WBGene00004506", "O17071", "WBGene00004504", "Q18115", "WBGene00004459", "Q20938", "WBGene00004462", "Q19324", "WBGene00004461", "Q22253", "WBGene00004465", "Q9GZH5", "WBGene00004458", "Q04908", "WBGene00004460", "O61742", "WBGene00004466", "O76577", "WBGene00004467", "Q20058", "WBGene00009445", "O44156", "WBGene00003927", "Q20585", "WBGene00004463", "Q27488", "WBGene00003923", "O61792", "WBGene00004464", "Q09583", "WBGene00003928", "Q23449", "WBGene00004468", "Q9N599", "WBGene00003924", "Q10920", "WBGene00016623", "Q95008", "WBGene00003926", "Q95PZ7", "WBGene00013435", "O17586", "WBGene00003922", "Q95005", "WBGene00003925", "P34286", "WBGene00003952", "P91477", "WBGene00003950" ] }, "reaction_10568346": { "compartment": "compartment_70101", "id": "reaction_10568346", "reactome": "R-CEL-8937814", "name": "RUNX3 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10568334" ], "products": [ "species_10566205" ], "modifiers": [ [ "species_10511431", "catalyst" ], [ "species_10518187", "inhibitor" ] ], "additional_components": [ "WBGene00004393", "WBGene00004393", "G5EBY8", "WBGene00006852", "G5EEL5", "WBGene00000936", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635" ] }, "reaction_10518768": { "compartment": "compartment_876", "id": "reaction_10518768", "reactome": "R-CEL-374686", "name": "L1 interaction with Integrins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10518718", "species_10518764" ], "products": [ "species_10518766" ], "modifiers": [], "additional_components": [ "Q21465", "WBGene00019727", "Q5WRR1", "WBGene00006942", "P34446", "WBGene00003929", "Q27874", "WBGene00003930", "P34446", "WBGene00003929", "Q27874", "WBGene00003930", "Q21465", "WBGene00019727", "Q5WRR1", "WBGene00006942" ] }, "reaction_10524706": { "compartment": "compartment_70101", "id": "reaction_10524706", "reactome": "R-CEL-445064", "name": "Activation of Rac1 by VAV2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10520575", "species_29438" ], "products": [ "species_29420", "species_10509457" ], "modifiers": [ [ "species_10524306", "catalyst" ] ], "additional_components": [ "species_29420", "Q03206", "ced-10", "species_29438", "Q03206", "ced-10", "WBGene00006887" ] }, "reaction_10524710": { "compartment": "compartment_876", "id": "reaction_10524710", "reactome": "R-CEL-445069", "name": "L1-EGFR trans-heterodimerization", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10518718", "species_10512185" ], "products": [ "species_10524708" ], "modifiers": [], "additional_components": [ "Q21465", "WBGene00019727", "Q5WRR1", "WBGene00006942", "WBGene00002299", "P24348", "WBGene00002299", "Q21465", "WBGene00019727", "Q5WRR1", "WBGene00006942" ] }, "reaction_10521079": { "compartment": "compartment_70101", "id": "reaction_10521079", "reactome": "R-CEL-392752", "name": "Phosphorylation of L1 by CK-II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10518718", "species_10515097", "species_113592" ], "products": [ "species_29370", "species_10521077" ], "modifiers": [ [ "species_10515097", "catalyst" ] ], "additional_components": [ "Q21465", "WBGene00019727", "Q5WRR1", "WBGene00006942", "P18334", "WBGene00002191", "P28548", "WBGene00002196", "Q5WRR1", "WBGene00006942", "Q21465", "WBGene00019727", "P18334", "WBGene00002191", "P28548", "WBGene00002196", "P18334", "WBGene00002191", "P28548", "WBGene00002196" ] }, "reaction_10518762": { "compartment": "compartment_876", "id": "reaction_10518762", "reactome": "R-CEL-374681", "name": "L1 and NCAM1 engaged in cis-interaction", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10518718", "species_10518758" ], "products": [ "species_10518760" ], "modifiers": [], "additional_components": [ "Q21465", "WBGene00019727", "Q5WRR1", "WBGene00006942", "WBGene00004372", "C6KRM7", "WBGene00004372", "Q21465", "WBGene00019727", "Q5WRR1", "WBGene00006942" ] }, "reaction_10524715": { "compartment": "compartment_70101", "id": "reaction_10524715", "reactome": "R-CEL-445072", "name": "Interaction of PAK1 with Rac1-GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10509457", "species_10520672" ], "products": [ "species_10520670", "species_29370", "species_10524712" ], "modifiers": [ [ "species_10520670", "catalyst" ] ], "additional_components": [ "species_29438", "Q03206", "ced-10", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "species_29438", "Q03206", "ced-10", "Q17850", "WBGene00003911", "G5EGQ3", "WBGene00003144", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911" ] }, "reaction_10516546": { "compartment": "compartment_984", "id": "reaction_10516546", "reactome": "R-CEL-210404", "name": "SLC1A1-3,6,7 exchange L-Glu, H+ and 3Na+ for K+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_210382", "species_29804", "species_74113" ], "products": [ "species_74126", "species_29404", "species_70106", "species_83910" ], "modifiers": [ [ "species_10516538", "catalyst" ], [ "species_10516544", "inhibitor" ] ], "additional_components": [ "Q21353", "WBGene00001621", "Q21751", "WBGene00001624", "Q22682", "WBGene00001622", "Q9UAY8", "WBGene00001625", "O18210", "WBGene00001623", "Q10901", "WBGene00001620", "WBGene00017070" ] }, "reaction_10516838": { "compartment": "compartment_70101", "id": "reaction_10516838", "reactome": "R-CEL-210444", "name": "L-Glutamate loading of synaptic vesicle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29404", "species_10516835" ], "products": [ "species_10516719" ], "modifiers": [ [ "species_10516835", "catalyst" ] ], "additional_components": [ "P34644", "WBGene00001135", "Q10046", "WBGene00011556", "G5EEK1", "WBGene00010755", "Q94986", "WBGene00004267", "Q19136", "WBGene00006306", "K8FE10", "WBGene00004922", "Q23056", "WBGene00020861", "O16700", "WBGene00004925", "Q965S5", "WBGene00004923", "P34693", "WBGene00004921", "Q19767", "WBGene00004898", "G5EBK2", "WBGene00014084", "Q94057", "WBGene00044062", "O02495", "WBGene00004897", "Q95XH1", "WBGene00022077", "P34351", "WBGene00004899", "P34644", "WBGene00001135", "Q10046", "WBGene00011556", "G5EEK1", "WBGene00010755", "Q94986", "WBGene00004267", "Q19136", "WBGene00006306", "K8FE10", "WBGene00004922", "Q23056", "WBGene00020861", "O16700", "WBGene00004925", "Q965S5", "WBGene00004923", "P34693", "WBGene00004921", "Q19767", "WBGene00004898", "G5EBK2", "WBGene00014084", "Q94057", "WBGene00044062", "O02495", "WBGene00004897", "Q95XH1", "WBGene00022077", "P34351", "WBGene00004899", "species_113552", "P34644", "WBGene00001135", "Q10046", "WBGene00011556", "G5EEK1", "WBGene00010755", "Q94986", "WBGene00004267", "Q19136", "WBGene00006306", "K8FE10", "WBGene00004922", "Q23056", "WBGene00020861", "O16700", "WBGene00004925", "Q965S5", "WBGene00004923", "P34693", "WBGene00004921", "Q19767", "WBGene00004898", "G5EBK2", "WBGene00014084", "Q94057", "WBGene00044062", "O02495", "WBGene00004897", "Q95XH1", "WBGene00022077", "P34351", "WBGene00004899" ] }, "reaction_10516828": { "compartment": "compartment_984", "id": "reaction_10516828", "reactome": "R-CEL-210430", "name": "Release of L-Glutamate at the synapse", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10516779", "species_74016" ], "products": [ "species_210382", "species_10516825", "species_10516777", "species_10516809", "species_10516744", "species_10516823", "species_10516631", "species_10516791" ], "modifiers": [ [ "species_10516779", "catalyst" ], [ "species_74016", "catalyst" ] ], "additional_components": [ "G5EEN8", "WBGene00006454", "A5PEW5", "WBGene00004364", "P34815", "WBGene00006757", "Q9GUM7", "WBGene00022271", "Q21049", "WBGene00006364", "Q22366", "WBGene00006750", "P27715", "WBGene00006752", "Q9N415", "WBGene00006513", "O16000", "WBGene00006798", "P34644", "WBGene00001135", "Q10046", "WBGene00011556", "G5EEK1", "WBGene00010755", "Q94986", "WBGene00004267", "Q19136", "WBGene00006306", "K8FE10", "WBGene00004922", "Q23056", "WBGene00020861", "O16700", "WBGene00004925", "Q965S5", "WBGene00004923", "P34693", "WBGene00004921", "Q19767", "WBGene00004898", "G5EBK2", "WBGene00014084", "Q94057", "WBGene00044062", "O02495", "WBGene00004897", "Q95XH1", "WBGene00022077", "P34351", "WBGene00004899", "species_113552", "WBGene00004267", "Q21049", "WBGene00006364", "Q22366", "WBGene00006750", "P27715", "WBGene00006752", "Q9N415", "WBGene00006513", "species_74016", "G5EEN8", "WBGene00006454", "A5PEW5", "WBGene00004364", "Q94057", "WBGene00044062", "Q95XH1", "WBGene00022077", "G5EBK2", "WBGene00014084", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q19767", "WBGene00004898", "O16000", "WBGene00006798", "WBGene00022271", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "WBGene00006757", "G5EEK1", "WBGene00010755", "P34644", "WBGene00001135", "Q10046", "WBGene00011556", "G5EEN8", "WBGene00006454", "A5PEW5", "WBGene00004364", "P34815", "WBGene00006757", "Q9GUM7", "WBGene00022271", "Q21049", "WBGene00006364", "Q22366", "WBGene00006750", "P27715", "WBGene00006752", "Q9N415", "WBGene00006513", "O16000", "WBGene00006798", "P34644", "WBGene00001135", "Q10046", "WBGene00011556", "G5EEK1", "WBGene00010755", "Q94986", "WBGene00004267", "Q19136", "WBGene00006306", "K8FE10", "WBGene00004922", "Q23056", "WBGene00020861", "O16700", "WBGene00004925", "Q965S5", "WBGene00004923", "P34693", "WBGene00004921", "Q19767", "WBGene00004898", "G5EBK2", "WBGene00014084", "Q94057", "WBGene00044062", "O02495", "WBGene00004897", "Q95XH1", "WBGene00022077", "P34351", "WBGene00004899", "species_113552" ] }, "reaction_10516782": { "compartment": "compartment_70101", "id": "reaction_10516782", "reactome": "R-CEL-210426", "name": "Glutamate synaptic vesicle docking and priming", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10516719", "species_10516749", "species_10516777", "species_10516744", "species_10516631", "species_10516739" ], "products": [ "species_10516779" ], "modifiers": [ [ "species_10516719", "catalyst" ], [ "species_10516759", "catalyst" ] ], "additional_components": [ "P34644", "WBGene00001135", "Q10046", "WBGene00011556", "G5EEK1", "WBGene00010755", "Q94986", "WBGene00004267", "Q19136", "WBGene00006306", "K8FE10", "WBGene00004922", "Q23056", "WBGene00020861", "O16700", "WBGene00004925", "Q965S5", "WBGene00004923", "P34693", "WBGene00004921", "Q19767", "WBGene00004898", "G5EBK2", "WBGene00014084", "Q94057", "WBGene00044062", "O02495", "WBGene00004897", "Q95XH1", "WBGene00022077", "P34351", "WBGene00004899", "species_113552", "WBGene00006798", "Q21049", "WBGene00006364", "Q22366", "WBGene00006750", "P27715", "WBGene00006752", "Q9N415", "WBGene00006513", "WBGene00022271", "WBGene00006757", "G5EEN8", "WBGene00006454", "A5PEW5", "WBGene00004364", "G5EEN8", "WBGene00006454", "A5PEW5", "WBGene00004364", "P34815", "WBGene00006757", "Q9GUM7", "WBGene00022271", "Q21049", "WBGene00006364", "Q22366", "WBGene00006750", "P27715", "WBGene00006752", "Q9N415", "WBGene00006513", "O16000", "WBGene00006798", "P34644", "WBGene00001135", "Q10046", "WBGene00011556", "G5EEK1", "WBGene00010755", "Q94986", "WBGene00004267", "Q19136", "WBGene00006306", "K8FE10", "WBGene00004922", "Q23056", "WBGene00020861", "O16700", "WBGene00004925", "Q965S5", "WBGene00004923", "P34693", "WBGene00004921", "Q19767", "WBGene00004898", "G5EBK2", "WBGene00014084", "Q94057", "WBGene00044062", "O02495", "WBGene00004897", "Q95XH1", "WBGene00022077", "P34351", "WBGene00004899", "species_113552", "P34644", "WBGene00001135", "Q10046", "WBGene00011556", "G5EEK1", "WBGene00010755", "Q94986", "WBGene00004267", "Q19136", "WBGene00006306", "K8FE10", "WBGene00004922", "Q23056", "WBGene00020861", "O16700", "WBGene00004925", "Q965S5", "WBGene00004923", "P34693", "WBGene00004921", "Q19767", "WBGene00004898", "G5EBK2", "WBGene00014084", "Q94057", "WBGene00044062", "O02495", "WBGene00004897", "Q95XH1", "WBGene00022077", "P34351", "WBGene00004899", "species_113552", "WBGene00006752" ] }, "reaction_10543028": { "compartment": "compartment_5460", "id": "reaction_10543028", "reactome": "R-CEL-2162186", "name": "DeMQ10H2 is methylated to Q10H2 by COQ3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2162265", "species_2162212" ], "products": [ "species_2162252", "species_113529", "species_2162198" ], "modifiers": [ [ "species_10543025", "catalyst" ] ], "additional_components": [ "WBGene00000763" ] }, "reaction_10543036": { "compartment": "compartment_70616", "id": "reaction_10543036", "reactome": "R-CEL-2162192", "name": "PHB and all-E-10PrP2 are combined into DHB by COQ2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2162214", "species_2162213" ], "products": [ "species_2162207", "species_159450" ], "modifiers": [ [ "species_10543033", "catalyst" ] ], "additional_components": [ "WBGene00000762" ] }, "reaction_10543039": { "compartment": "compartment_5460", "id": "reaction_10543039", "reactome": "R-CEL-2162193", "name": "DHDB is methylated to MHDB by COQ3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2162265", "species_2162209" ], "products": [ "species_2162252", "species_113529", "species_2162215" ], "modifiers": [ [ "species_10543025", "catalyst" ] ], "additional_components": [ "WBGene00000763" ] }, "reaction_10518304": { "compartment": "compartment_70101", "id": "reaction_10518304", "reactome": "R-CEL-372505", "name": "Acetylcholine synaptic vesicle docking and priming", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10517503", "species_10516749", "species_10516777", "species_10516744", "species_10516631", "species_10516739" ], "products": [ "species_10518301" ], "modifiers": [ [ "species_10517503", "catalyst" ] ], "additional_components": [ "species_372533", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "P34711", "WBGene00006756", "Q19767", "WBGene00004898", "G5EBK2", "WBGene00014084", "Q94057", "WBGene00044062", "O02495", "WBGene00004897", "Q95XH1", "WBGene00022077", "P34351", "WBGene00004899", "Q94986", "WBGene00004267", "WBGene00006798", "Q21049", "WBGene00006364", "Q22366", "WBGene00006750", "P27715", "WBGene00006752", "Q9N415", "WBGene00006513", "WBGene00022271", "WBGene00006757", "G5EEN8", "WBGene00006454", "A5PEW5", "WBGene00004364", "G5EEN8", "WBGene00006454", "A5PEW5", "WBGene00004364", "P34815", "WBGene00006757", "Q9GUM7", "WBGene00022271", "Q21049", "WBGene00006364", "Q22366", "WBGene00006750", "P27715", "WBGene00006752", "Q9N415", "WBGene00006513", "O16000", "WBGene00006798", "species_372533", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "P34711", "WBGene00006756", "Q19767", "WBGene00004898", "G5EBK2", "WBGene00014084", "Q94057", "WBGene00044062", "O02495", "WBGene00004897", "Q95XH1", "WBGene00022077", "P34351", "WBGene00004899", "Q94986", "WBGene00004267", "species_372533", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "P34711", "WBGene00006756", "Q19767", "WBGene00004898", "G5EBK2", "WBGene00014084", "Q94057", "WBGene00044062", "O02495", "WBGene00004897", "Q95XH1", "WBGene00022077", "P34351", "WBGene00004899", "Q94986", "WBGene00004267" ] }, "reaction_10518401": { "compartment": "compartment_876", "id": "reaction_10518401", "reactome": "R-CEL-372529", "name": "Release of acetylcholine at the synapse", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10518301" ], "products": [ "species_10518398", "species_10516825", "species_10516777", "species_10516744", "species_10516823", "species_10516631", "species_10516807", "species_372533" ], "modifiers": [ [ "species_10518301", "catalyst" ] ], "additional_components": [ "G5EEN8", "WBGene00006454", "A5PEW5", "WBGene00004364", "P34815", "WBGene00006757", "Q9GUM7", "WBGene00022271", "Q21049", "WBGene00006364", "Q22366", "WBGene00006750", "P27715", "WBGene00006752", "Q9N415", "WBGene00006513", "O16000", "WBGene00006798", "species_372533", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "P34711", "WBGene00006756", "Q19767", "WBGene00004898", "G5EBK2", "WBGene00014084", "Q94057", "WBGene00044062", "O02495", "WBGene00004897", "Q95XH1", "WBGene00022077", "P34351", "WBGene00004899", "Q94986", "WBGene00004267", "WBGene00006756", "WBGene00004267", "Q21049", "WBGene00006364", "Q22366", "WBGene00006750", "P27715", "WBGene00006752", "Q9N415", "WBGene00006513", "WBGene00022271", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "WBGene00006757", "G5EEN8", "WBGene00006454", "A5PEW5", "WBGene00004364", "Q94057", "WBGene00044062", "Q95XH1", "WBGene00022077", "G5EBK2", "WBGene00014084", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q19767", "WBGene00004898", "O16000", "WBGene00006798", "G5EEN8", "WBGene00006454", "A5PEW5", "WBGene00004364", "P34815", "WBGene00006757", "Q9GUM7", "WBGene00022271", "Q21049", "WBGene00006364", "Q22366", "WBGene00006750", "P27715", "WBGene00006752", "Q9N415", "WBGene00006513", "O16000", "WBGene00006798", "species_372533", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "P34711", "WBGene00006756", "Q19767", "WBGene00004898", "G5EBK2", "WBGene00014084", "Q94057", "WBGene00044062", "O02495", "WBGene00004897", "Q95XH1", "WBGene00022077", "P34351", "WBGene00004899", "Q94986", "WBGene00004267" ] }, "reaction_10517506": { "compartment": "compartment_70101", "id": "reaction_10517506", "reactome": "R-CEL-264615", "name": "Loading of acetylcholine in synaptic vesicles", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10517501", "species_372511", "species_264643" ], "products": [ "species_10517503", "species_70106" ], "modifiers": [ [ "species_10517483", "catalyst" ] ], "additional_components": [ "P34711", "WBGene00006756", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "Q19767", "WBGene00004898", "G5EBK2", "WBGene00014084", "Q94057", "WBGene00044062", "O02495", "WBGene00004897", "Q95XH1", "WBGene00022077", "P34351", "WBGene00004899", "Q94986", "WBGene00004267", "species_372533", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "P34711", "WBGene00006756", "Q19767", "WBGene00004898", "G5EBK2", "WBGene00014084", "Q94057", "WBGene00044062", "O02495", "WBGene00004897", "Q95XH1", "WBGene00022077", "P34351", "WBGene00004899", "Q94986", "WBGene00004267", "WBGene00006756" ] }, "reaction_10517514": { "compartment": "compartment_70101", "id": "reaction_10517514", "reactome": "R-CEL-264622", "name": "Cho is acetylated to AcCho by CHAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_264618", "species_76183" ], "products": [ "species_264643", "species_76194" ], "modifiers": [ [ "species_10517511", "catalyst" ] ], "additional_components": [ "WBGene00000481" ] }, "reaction_10554130": { "compartment": "compartment_18730", "id": "reaction_10554130", "reactome": "R-CEL-5638004", "name": "RP2 binds ARL3:GTP:UNC119B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10554126", "species_10554121" ], "products": [ "species_10554128" ], "modifiers": [], "additional_components": [ "WBGene00019536", "species_29438", "O45379", "WBGene00000188", "Q10658", "WBGene00006843", "species_29438", "O45379", "WBGene00000188", "Q10658", "WBGene00006843", "Q966I6", "WBGene00019536" ] }, "reaction_10554148": { "compartment": "compartment_18730", "id": "reaction_10554148", "reactome": "R-CEL-5638016", "name": "RP2:ARL3:GDP:UNC119B dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10554134" ], "products": [ "species_10554126", "species_10554119", "species_10554132" ], "modifiers": [], "additional_components": [ "O45379", "WBGene00000188", "species_29420", "Q10658", "WBGene00006843", "Q966I6", "WBGene00019536", "WBGene00019536", "WBGene00006843", "O45379", "WBGene00000188", "species_29420" ] }, "reaction_10554137": { "compartment": "compartment_18730", "id": "reaction_10554137", "reactome": "R-CEL-5638006", "name": "ARL3 hydrolyzes GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10554128" ], "products": [ "species_10554134" ], "modifiers": [ [ "species_10554128", "catalyst" ] ], "additional_components": [ "species_29438", "O45379", "WBGene00000188", "Q10658", "WBGene00006843", "Q966I6", "WBGene00019536", "O45379", "WBGene00000188", "species_29420", "Q10658", "WBGene00006843", "Q966I6", "WBGene00019536", "species_29438", "O45379", "WBGene00000188", "Q10658", "WBGene00006843", "Q966I6", "WBGene00019536" ] }, "reaction_10554140": { "compartment": "compartment_18730", "id": "reaction_10554140", "reactome": "R-CEL-5638007", "name": "RP2 activates the GTPase activity of ARL3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10554128" ], "products": [ "species_10554128" ], "modifiers": [ [ "species_10554126", "catalyst" ] ], "additional_components": [ "species_29438", "O45379", "WBGene00000188", "Q10658", "WBGene00006843", "Q966I6", "WBGene00019536", "species_29438", "O45379", "WBGene00000188", "Q10658", "WBGene00006843", "Q966I6", "WBGene00019536", "WBGene00019536" ] }, "reaction_10553222": { "compartment": "compartment_261122", "id": "reaction_10553222", "reactome": "R-CEL-5623527", "name": "VxPx-containing ciliary membrane proteins are delivered to the ciliary membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10553196" ], "products": [ "species_10553220" ], "modifiers": [], "additional_components": [ "Q03611", "WBGene00006526", "Q7Z205", "WBGene00000563", "Q9N4C1", "WBGene00022295", "A8WI01", "WBGene00000562", "O61827", "WBGene00000487", "G5EEE2", "WBGene00006525", "O01803", "WBGene00004274", "species_29438", "Q95ZS6", "WBGene00018869", "Q20759", "WBGene00010045", "G5EFC1", "WBGene00004272", "Q21137", "WBGene00019317", "Q9XWS2", "WBGene00004753", "Q18406", "WBGene00016376", "Q18286", "WBGene00016188", "P91149", "WBGene00016606", "Q95Q35", "WBGene00013687", "Q20678", "WBGene00018703", "Q22706", "WBGene00004752", "Q19262", "WBGene00017284", "Q03611", "WBGene00006526", "A8WI01", "WBGene00000562", "O61827", "WBGene00000487", "Q7Z205", "WBGene00000563", "Q9N4C1", "WBGene00022295", "G5EEE2", "WBGene00006525" ] }, "reaction_10553129": { "compartment": "compartment_70101", "id": "reaction_10553129", "reactome": "R-CEL-5623508", "name": "GBF1 stimulates nucleotide exchange on ARF4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10553127" ], "products": [ "species_10553068", "species_29420" ], "modifiers": [ [ "species_10517992", "catalyst" ] ], "additional_components": [ "Q94231", "WBGene00000190", "species_29420", "Q94231", "WBGene00000190", "species_29438", "WBGene00007703" ] }, "reaction_10553198": { "compartment": "compartment_13949", "id": "reaction_10553198", "reactome": "R-CEL-5623524", "name": "The exocyst complex binds to RAB3IP in the ciliary targeting complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10553194", "species_10553176" ], "products": [ "species_10553196" ], "modifiers": [], "additional_components": [ "Q9XWS2", "WBGene00004753", "Q18406", "WBGene00016376", "Q18286", "WBGene00016188", "P91149", "WBGene00016606", "Q95Q35", "WBGene00013687", "Q20678", "WBGene00018703", "Q22706", "WBGene00004752", "Q19262", "WBGene00017284", "Q03611", "WBGene00006526", "Q7Z205", "WBGene00000563", "Q9N4C1", "WBGene00022295", "A8WI01", "WBGene00000562", "O61827", "WBGene00000487", "G5EEE2", "WBGene00006525", "O01803", "WBGene00004274", "species_29438", "Q95ZS6", "WBGene00018869", "Q20759", "WBGene00010045", "G5EFC1", "WBGene00004272", "Q21137", "WBGene00019317", "Q03611", "WBGene00006526", "Q7Z205", "WBGene00000563", "Q9N4C1", "WBGene00022295", "A8WI01", "WBGene00000562", "O61827", "WBGene00000487", "G5EEE2", "WBGene00006525", "O01803", "WBGene00004274", "species_29438", "Q95ZS6", "WBGene00018869", "Q20759", "WBGene00010045", "G5EFC1", "WBGene00004272", "Q21137", "WBGene00019317", "Q9XWS2", "WBGene00004753", "Q18406", "WBGene00016376", "Q18286", "WBGene00016188", "P91149", "WBGene00016606", "Q95Q35", "WBGene00013687", "Q20678", "WBGene00018703", "Q22706", "WBGene00004752", "Q19262", "WBGene00017284" ] }, "reaction_10553265": { "compartment": "compartment_70101", "id": "reaction_10553265", "reactome": "R-CEL-5624125", "name": "Formation of the BBSome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10552766", "species_10552796", "species_10552781", "species_10552776", "species_10552791", "species_10552786", "species_10552771", "species_10552801" ], "products": [ "species_10552803" ], "modifiers": [], "additional_components": [ "WBGene00000241", "WBGene00000244", "WBGene00010974", "WBGene00043992", "WBGene00016744", "WBGene00003892", "WBGene00000242", "WBGene00019482", "Q21273", "WBGene00019482", "Q19640", "WBGene00000242", "Q9XW70", "WBGene00003892", "O01514", "WBGene00016744", "Q5CZ52", "WBGene00043992", "Q21626", "WBGene00010974", "Q23049", "WBGene00000244", "Q9NEZ7", "WBGene00000241" ] }, "reaction_10553298": { "compartment": "compartment_876", "id": "reaction_10553298", "reactome": "R-CEL-5624126", "name": "ARL6:GTP and the BBSome bind ciliary cargo", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10553294", "species_10553272", "species_10552803" ], "products": [ "species_10553296" ], "modifiers": [], "additional_components": [ "H9G358", "WBGene00018089", "P34311", "WBGene00018089", "Q09502", "WBGene00008065", "Q20841", "WBGene00018886", "Q23033", "WBGene00020086", "A0A0K3AXD3", "WBGene00011372", "Q9XVQ0", "WBGene00018089", "A0A2C9C3A4", "WBGene00018089", "A0A3B1DQQ4", "WBGene00006864", "Q18510", "WBGene00000193", "species_29438", "Q21273", "WBGene00019482", "Q19640", "WBGene00000242", "Q9XW70", "WBGene00003892", "O01514", "WBGene00016744", "Q5CZ52", "WBGene00043992", "Q21626", "WBGene00010974", "Q23049", "WBGene00000244", "Q9NEZ7", "WBGene00000241", "Q21273", "WBGene00019482", "Q19640", "WBGene00000242", "Q9XW70", "WBGene00003892", "O01514", "WBGene00016744", "Q5CZ52", "WBGene00043992", "Q21626", "WBGene00010974", "Q23049", "WBGene00000244", "Q9NEZ7", "WBGene00000241", "Q18510", "WBGene00000193", "species_29438", "H9G358", "WBGene00018089", "P34311", "WBGene00018089", "Q09502", "WBGene00008065", "Q20841", "WBGene00018886", "Q23033", "WBGene00020086", "A0A0K3AXD3", "WBGene00011372", "Q9XVQ0", "WBGene00018089", "A0A2C9C3A4", "WBGene00018089", "A0A3B1DQQ4", "WBGene00006864" ] }, "reaction_10553354": { "compartment": "compartment_261122", "id": "reaction_10553354", "reactome": "R-CEL-5624127", "name": "ARL6:GTP and the BBSome target cargo to the primary cilium", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10553296" ], "products": [ "species_10553346" ], "modifiers": [ [ "species_10553352", "inhibitor" ] ], "additional_components": [ "Q21273", "WBGene00019482", "Q19640", "WBGene00000242", "Q9XW70", "WBGene00003892", "O01514", "WBGene00016744", "Q5CZ52", "WBGene00043992", "Q21626", "WBGene00010974", "Q23049", "WBGene00000244", "Q9NEZ7", "WBGene00000241", "Q18510", "WBGene00000193", "species_29438", "H9G358", "WBGene00018089", "P34311", "WBGene00018089", "Q09502", "WBGene00008065", "Q20841", "WBGene00018886", "Q23033", "WBGene00020086", "A0A0K3AXD3", "WBGene00011372", "Q9XVQ0", "WBGene00018089", "A0A2C9C3A4", "WBGene00018089", "A0A3B1DQQ4", "WBGene00006864", "species_29438", "Q18510", "WBGene00000193", "Q21273", "WBGene00019482", "Q19640", "WBGene00000242", "Q9XW70", "WBGene00003892", "O01514", "WBGene00016744", "Q5CZ52", "WBGene00043992", "Q21626", "WBGene00010974", "Q23049", "WBGene00000244", "Q9NEZ7", "WBGene00000241", "Q20841", "WBGene00018886", "Q23033", "WBGene00020086", "A0A0K3AXD3", "WBGene00011372", "Q9XVQ0", "WBGene00018089", "A0A2C9C3A4", "WBGene00018089", "A0A3B1DQQ4", "WBGene00006864", "H9G358", "WBGene00018089", "P34311", "WBGene00018089", "Q09502", "WBGene00008065", "Q21273", "WBGene00019482", "Q19640", "WBGene00000242", "Q9XW70", "WBGene00003892", "O01514", "WBGene00016744", "Q5CZ52", "WBGene00043992", "Q21626", "WBGene00010974", "Q23049", "WBGene00000244", "Q9NEZ7", "WBGene00000241" ] }, "reaction_10552812": { "compartment": "compartment_2132649", "id": "reaction_10552812", "reactome": "R-CEL-5617815", "name": "BBSome binds RAB3IP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10552808", "species_10552803" ], "products": [ "species_10552810" ], "modifiers": [], "additional_components": [ "WBGene00010045", "Q21273", "WBGene00019482", "Q19640", "WBGene00000242", "Q9XW70", "WBGene00003892", "O01514", "WBGene00016744", "Q5CZ52", "WBGene00043992", "Q21626", "WBGene00010974", "Q23049", "WBGene00000244", "Q9NEZ7", "WBGene00000241", "Q21273", "WBGene00019482", "Q19640", "WBGene00000242", "Q9XW70", "WBGene00003892", "O01514", "WBGene00016744", "Q5CZ52", "WBGene00043992", "Q21626", "WBGene00010974", "Q23049", "WBGene00000244", "Q9NEZ7", "WBGene00000241", "Q20759", "WBGene00010045" ] }, "reaction_10521804": { "compartment": "compartment_70101", "id": "reaction_10521804", "reactome": "R-CEL-418456", "name": "cGMP is degraded by PDEs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30991" ], "products": [ "species_113578" ], "modifiers": [ [ "species_10521801", "catalyst" ] ], "additional_components": [ "P30645", "WBGene00011146", "P91119", "WBGene00016328", "O18696", "WBGene00011433" ] }, "reaction_10514144": { "compartment": "compartment_70101", "id": "reaction_10514144", "reactome": "R-CEL-198845", "name": "CYB5A:heme reduces Asc.- to AscH-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1497805", "species_10514130" ], "products": [ "species_198816", "species_10514128" ], "modifiers": [ [ "species_10514130", "catalyst" ] ], "additional_components": [ "species_71185", "O01816", "WBGene00020931", "Q93315", "WBGene00007848", "CHEBI:36144", "O01816", "WBGene00020931", "Q93315", "WBGene00007848", "species_71185", "O01816", "WBGene00020931", "Q93315", "WBGene00007848" ] }, "reaction_10514114": { "compartment": "compartment_876", "id": "reaction_10514114", "reactome": "R-CEL-198818", "name": "SLC2A1,3 transports DeHA from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_198852" ], "products": [ "species_198827" ], "modifiers": [ [ "species_10514111", "catalyst" ] ], "additional_components": [ "Q21381", "WBGene00043980", "Q9GYQ1", "WBGene00043980", "Q21382", "WBGene00043980", "Q9NEI8", "WBGene00043980", "Q21385", "WBGene00043980", "Q5WRR9", "WBGene00043980" ] }, "reaction_10514195": { "compartment": "compartment_876", "id": "reaction_10514195", "reactome": "R-CEL-198870", "name": "SLC23A1,2 cotransports AscH-, 2Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_198836", "species_74113" ], "products": [ "species_83910", "species_198816" ], "modifiers": [ [ "species_10514192", "catalyst" ] ], "additional_components": [ "O18061", "WBGene00021994", "D6RYE3", "WBGene00021994", "Q18771", "WBGene00021994", "G8JZM6", "WBGene00021994", "Q9TYX7", "WBGene00021994", "O18057", "WBGene00021994" ] }, "reaction_10514075": { "compartment": "compartment_70101", "id": "reaction_10514075", "reactome": "R-CEL-198813", "name": "GSTO dimers reduce DeHA to AscH-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29450", "species_198827" ], "products": [ "species_198816", "species_111745" ], "modifiers": [ [ "species_10514072", "catalyst" ] ], "additional_components": [ "P34277", "WBGene00015337", "D7SFI3", "WBGene00043097", "P34345", "WBGene00016204", "O17234", "WBGene00019636", "O45352", "WBGene00001792" ] }, "reaction_10514141": { "compartment": "compartment_70101", "id": "reaction_10514141", "reactome": "R-CEL-198824", "name": "CYB5R3:FAD reduces CYB5A:ferriheme to CYB5A:heme", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_73473", "species_10514128" ], "products": [ "species_10514130", "species_29360" ], "modifiers": [ [ "species_10514138", "catalyst" ] ], "additional_components": [ "CHEBI:36144", "O01816", "WBGene00020931", "Q93315", "WBGene00007848", "species_71185", "O01816", "WBGene00020931", "Q93315", "WBGene00007848", "O16521", "WBGene00020268", "species_113596" ] }, "reaction_10529632": { "compartment": "compartment_70101", "id": "reaction_10529632", "reactome": "R-CEL-964958", "name": "2xPDXK:2xZn2+ phosphorylates PXA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_964945", "species_113592" ], "products": [ "species_29370", "species_965146" ], "modifiers": [ [ "species_10529629", "catalyst" ] ], "additional_components": [ "species_216785", "O01824", "WBGene00019008" ] }, "reaction_10529648": { "compartment": "compartment_70101", "id": "reaction_10529648", "reactome": "R-CEL-965079", "name": "2xPNPO:2xFMN oxidizes PXAP to PXLP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_29368", "species_965146" ], "products": [ "species_29390", "species_31633", "species_29408" ], "modifiers": [ [ "species_10529643", "catalyst" ] ], "additional_components": [ "species_73524", "Q20939", "WBGene00018996" ] }, "reaction_10529634": { "compartment": "compartment_70101", "id": "reaction_10529634", "reactome": "R-CEL-964962", "name": "2xPDKX:2xZn2+ phosphorylates PDX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_965053" ], "products": [ "species_29370", "species_964952" ], "modifiers": [ [ "species_10529629", "catalyst" ] ], "additional_components": [ "species_216785", "O01824", "WBGene00019008" ] }, "reaction_10529636": { "compartment": "compartment_70101", "id": "reaction_10529636", "reactome": "R-CEL-964970", "name": "2xPDXK:2xZn2+ phosphorylates PXL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_965131" ], "products": [ "species_29390", "species_29370" ], "modifiers": [ [ "species_10529629", "catalyst" ] ], "additional_components": [ "species_216785", "O01824", "WBGene00019008" ] }, "reaction_10546502": { "compartment": "compartment_70101", "id": "reaction_10546502", "reactome": "R-CEL-3204311", "name": "AOX1 oxidises PXL to PDXate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_29368", "species_965131" ], "products": [ "species_3204324", "species_29408" ], "modifiers": [ [ "species_10546499", "catalyst" ] ], "additional_components": [ "CHEBI:33722", "CHEBI:44074", "species_113596", "O17892", "WBGene00010083", "O61198", "WBGene00017487", "Q960A1", "WBGene00015057" ] }, "reaction_10529646": { "compartment": "compartment_70101", "id": "reaction_10529646", "reactome": "R-CEL-965019", "name": "2xPNPO:2xFMN oxidizes PDXP to PXLP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_964952" ], "products": [ "species_29390", "species_29408" ], "modifiers": [ [ "species_10529643", "catalyst" ] ], "additional_components": [ "species_73524", "Q20939", "WBGene00018996" ] }, "reaction_10513776": { "compartment": "compartment_70101", "id": "reaction_10513776", "reactome": "R-CEL-197235", "name": "NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_197220" ], "products": [ "species_197256", "species_1132084" ], "modifiers": [ [ "species_10513773", "catalyst" ] ], "additional_components": [ "species_114632", "P91851", "WBGene00009176", "Q9XXM2", "WBGene00012295" ] }, "reaction_10514608": { "compartment": "compartment_5460", "id": "reaction_10514608", "reactome": "R-CEL-200474", "name": "NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8938083", "species_113593" ], "products": [ "species_8938078", "species_8938090" ], "modifiers": [ [ "species_10514605", "catalyst" ] ], "additional_components": [ "species_114632", "P91851", "WBGene00009176", "Q9XXM2", "WBGene00012295" ] }, "reaction_10523473": { "compartment": "compartment_876", "id": "reaction_10523473", "reactome": "R-CEL-429749", "name": "SLC5A8 transports monocarboxylates from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_429739", "species_74113" ], "products": [ "species_83910", "species_429748" ], "modifiers": [ [ "species_10523470", "catalyst" ] ], "additional_components": [ "species_113557", "species_29708", "species_8869604", "CHEBI:30772", "species_427486", "CHEBI:30768", "CHEBI:30772", "species_113557", "species_427486", "species_29708", "CHEBI:30768", "species_197230", "WBGene00018716" ] }, "reaction_10563652": { "compartment": "compartment_17951", "id": "reaction_10563652", "reactome": "R-CEL-6809287", "name": "NUDT12 hydrolyses NADH to NMNH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_141343", "species_192305", "species_389620" ], "products": [ "species_6809289", "species_193465" ], "modifiers": [ [ "species_10563649", "catalyst" ] ], "additional_components": [ "WBGene00003586" ] }, "reaction_10563127": { "compartment": "compartment_5460", "id": "reaction_10563127", "reactome": "R-CEL-6806967", "name": "CARKD dehydrates S-NAD(P)HX to NADPH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113593", "species_6807477" ], "products": [ "species_113548", "species_113581", "species_113529", "species_113600" ], "modifiers": [ [ "species_10563124", "catalyst" ] ], "additional_components": [ "WBGene00011298" ] }, "reaction_10566729": { "compartment": "compartment_876", "id": "reaction_10566729", "reactome": "R-CEL-8869603", "name": "SLC22A13 transports NCA from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8869604" ], "products": [ "species_197230" ], "modifiers": [ [ "species_10566726", "catalyst" ] ], "additional_components": [ "WBGene00020701" ] }, "reaction_10551672": { "compartment": "compartment_70101", "id": "reaction_10551672", "reactome": "R-CEL-5359451", "name": "NNMT transfers CH3 from SAM to NAM to form MNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_197277", "species_71284" ], "products": [ "species_549282", "species_71285" ], "modifiers": [ [ "species_10511828", "catalyst" ] ], "additional_components": [ "WBGene00015124" ] }, "reaction_10563119": { "compartment": "compartment_5460", "id": "reaction_10563119", "reactome": "R-CEL-6806966", "name": "APOA1BP dimer epimerises R-NAD(P)HX to S-NAD(P)HX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6807473" ], "products": [ "species_6807477" ], "modifiers": [ [ "species_10563116", "catalyst" ] ], "additional_components": [ "Q9XW15", "WBGene00012476" ] }, "reaction_10513759": { "compartment": "compartment_70101", "id": "reaction_10513759", "reactome": "R-CEL-197186", "name": "NAPRT1 dimer transfers PRIB to NCA to form NAMN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73566", "species_197230", "species_70106" ], "products": [ "species_111294", "species_197220" ], "modifiers": [ [ "species_10513756", "catalyst" ], [ "species_29926", "catalyst" ] ], "additional_components": [ "Q95XX1", "WBGene00021882" ] }, "reaction_10568517": { "compartment": "compartment_70101", "id": "reaction_10568517", "reactome": "R-CEL-8939959", "name": "NMNAT2 transfers an adenylyl group from ATP to NMN to yield NAD+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8869353", "species_113592" ], "products": [ "species_1132084", "species_29360" ], "modifiers": [ [ "species_10513773", "catalyst" ] ], "additional_components": [ "species_114632", "P91851", "WBGene00009176", "Q9XXM2", "WBGene00012295" ] }, "reaction_10514615": { "compartment": "compartment_7660", "id": "reaction_10514615", "reactome": "R-CEL-200512", "name": "NMNAT1 transfers an adenylyl group from ATP to NAMN to yield NAAD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200492", "species_29358" ], "products": [ "species_8878981", "species_200499" ], "modifiers": [ [ "species_10514612", "catalyst" ] ], "additional_components": [ "P91851", "WBGene00009176", "species_216785" ] }, "reaction_10569958": { "compartment": "compartment_5460", "id": "reaction_10569958", "reactome": "R-CEL-8955030", "name": "NADK2 dimer phosphorylates NAD+ to NADP+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113593", "species_113526" ], "products": [ "species_113581", "species_113563", "species_113529" ], "modifiers": [ [ "species_10569955", "catalyst" ] ], "additional_components": [ "Q9XXI5", "WBGene00012463" ] }, "reaction_10513786": { "compartment": "compartment_70101", "id": "reaction_10513786", "reactome": "R-CEL-197271", "name": "NADSYN1 hexamer amidates NAAD to NAD+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_197256", "species_113592", "species_29472" ], "products": [ "species_111294", "species_29404", "species_76577", "species_29360" ], "modifiers": [ [ "species_10513783", "catalyst" ] ], "additional_components": [ "Q9XXK6", "WBGene00007698" ] }, "reaction_10513714": { "compartment": "compartment_70101", "id": "reaction_10513714", "reactome": "R-CEL-196840", "name": "3xPPCDC:3FMN decarboxylates PPC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_196834" ], "products": [ "species_196767", "species_113528" ], "modifiers": [ [ "species_10513711", "catalyst" ] ], "additional_components": [ "species_73524", "P91988", "WBGene00009138" ] }, "reaction_10513683": { "compartment": "compartment_70101", "id": "reaction_10513683", "reactome": "R-CEL-196753", "name": "2xPPCS ligates PPanK with Cys", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111707", "species_113592", "species_196786" ], "products": [ "species_111294", "species_196834", "species_76577" ], "modifiers": [ [ "species_10513680", "catalyst" ] ], "additional_components": [ "Q9BL36", "WBGene00022171" ] }, "reaction_10513704": { "compartment": "compartment_70101", "id": "reaction_10513704", "reactome": "R-CEL-196773", "name": "COASY phosphorylates DP-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_196778" ], "products": [ "species_29370", "species_76194" ], "modifiers": [ [ "species_10513688", "catalyst" ] ], "additional_components": [ "WBGene00022031" ] }, "reaction_10513691": { "compartment": "compartment_70101", "id": "reaction_10513691", "reactome": "R-CEL-196754", "name": "COASY transfers an adenylyl group from ATP to PPANT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_196767", "species_113592" ], "products": [ "species_111294", "species_196778" ], "modifiers": [ [ "species_10513688", "catalyst" ] ], "additional_components": [ "WBGene00022031" ] }, "reaction_10514238": { "compartment": "compartment_70101", "id": "reaction_10514238", "reactome": "R-CEL-199202", "name": "Phosphopantetheine conjugation of the ACP domain of FAS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10514230", "species_76194" ], "products": [ "species_10507450", "species_158466" ], "modifiers": [ [ "species_10514235", "catalyst" ] ], "additional_components": [ "WBGene00009342", "WBGene00009342", "WBGene00012142" ] }, "reaction_10567381": { "compartment": "compartment_17927", "id": "reaction_10567381", "reactome": "R-CEL-8875838", "name": "SLC25A19 transports ThDP from cytosol to mitochondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29480" ], "products": [ "species_8878387" ], "modifiers": [ [ "species_10567378", "catalyst" ] ], "additional_components": [ "WBGene00016588" ] }, "reaction_10513701": { "compartment": "compartment_70101", "id": "reaction_10513701", "reactome": "R-CEL-196761", "name": "2xTPK1:Mg2+ phosphorylates THMN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_196934" ], "products": [ "species_29480", "species_76577" ], "modifiers": [ [ "species_10513698", "catalyst" ] ], "additional_components": [ "P30636", "WBGene00014027", "species_114632" ] }, "reaction_10514362": { "compartment": "compartment_876", "id": "reaction_10514362", "reactome": "R-CEL-199626", "name": "SLC19A2/3 transport extracellular THMN to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_199622" ], "products": [ "species_196934" ], "modifiers": [ [ "species_10514359", "catalyst" ] ], "additional_components": [ "Q22931", "WBGene00044738", "O45166", "WBGene00018138", "Q17766", "WBGene00007388" ] }, "reaction_10546096": { "compartment": "compartment_70101", "id": "reaction_10546096", "reactome": "R-CEL-2993799", "name": "HLCS biotinylates 6xMCCC1:6xMCCC2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546090", "species_113592", "species_199207" ], "products": [ "species_111294", "species_10546094", "species_76577" ], "modifiers": [ [ "species_10546065", "catalyst" ] ], "additional_components": [ "O45430", "WBGene00009319", "P34385", "WBGene00303021", "P34385", "WBGene00303021", "O45430", "WBGene00009319", "WBGene00000259" ] }, "reaction_10546068": { "compartment": "compartment_70101", "id": "reaction_10546068", "reactome": "R-CEL-2993447", "name": "HLCS biotinylates 6x(PCCA:PCCB)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10546054", "species_199207" ], "products": [ "species_111294", "species_10546060", "species_76577" ], "modifiers": [ [ "species_10546065", "catalyst" ] ], "additional_components": [ "Q20676", "WBGene00018701", "Q19842", "WBGene00017864", "Q20676", "WBGene00018701", "Q19842", "WBGene00017864", "WBGene00000259" ] }, "reaction_10546117": { "compartment": "compartment_70101", "id": "reaction_10546117", "reactome": "R-CEL-2993814", "name": "HLCS biotinylates ACACA:Mn2+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_199207", "species_10546115" ], "products": [ "species_111294", "species_10507413", "species_76577" ], "modifiers": [ [ "species_10546065", "catalyst" ] ], "additional_components": [ "H2L0M0", "WBGene00004076", "Q9XUC3", "WBGene00012131", "species_266099", "Q9XUC3", "WBGene00012131", "H2L0M0", "WBGene00004076", "species_266099", "WBGene00000259" ] }, "reaction_10549065": { "compartment": "compartment_70101", "id": "reaction_10549065", "reactome": "R-CEL-4167511", "name": "HLCS biotinylates ACACB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10549063", "species_199207" ], "products": [ "species_111294", "species_10514575", "species_76577" ], "modifiers": [ [ "species_10546065", "catalyst" ] ], "additional_components": [ "H2L0M0", "WBGene00004076", "species_266099", "species_266099", "H2L0M0", "WBGene00004076", "WBGene00000259" ] }, "reaction_10546107": { "compartment": "compartment_70101", "id": "reaction_10546107", "reactome": "R-CEL-2993802", "name": "HLCS biotinylates PC:Mn2+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_199207", "species_10546100" ], "products": [ "species_111294", "species_10546105", "species_76577" ], "modifiers": [ [ "species_10546065", "catalyst" ] ], "additional_components": [ "O17732", "WBGene00004258", "species_266099", "O17732", "WBGene00004258", "species_266099", "WBGene00000259" ] }, "reaction_10547436": { "compartment": "compartment_70101", "id": "reaction_10547436", "reactome": "R-CEL-3323111", "name": "Cytoslic carboxylases translocate to mitochondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10547434" ], "products": [ "species_10546283" ], "modifiers": [], "additional_components": [ "O17732", "WBGene00004258", "species_266099", "Q20676", "WBGene00018701", "Q19842", "WBGene00017864", "P34385", "WBGene00303021", "O45430", "WBGene00009319", "species_266099", "O17732", "WBGene00004258", "Q19842", "WBGene00017864", "Q20676", "WBGene00018701", "P34385", "WBGene00303021", "O45430", "WBGene00009319" ] }, "reaction_10529569": { "compartment": "compartment_70101", "id": "reaction_10529569", "reactome": "R-CEL-947535", "name": "Cyclisation of GTP to precursor Z", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_29356", "species_71284" ], "products": [ "species_111294", "species_947537", "species_947703", "species_174390" ], "modifiers": [ [ "species_10529566", "catalyst" ] ], "additional_components": [ "CHEBI:33722", "Q20624", "WBGene00009885" ] }, "reaction_10529522": { "compartment": "compartment_70101", "id": "reaction_10529522", "reactome": "R-CEL-947499", "name": "Exchange of oxygen with sulfur in MoCo", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_947539", "species_111707" ], "products": [ "species_947575", "species_29432" ], "modifiers": [ [ "species_10529519", "catalyst" ] ], "additional_components": [ "WBGene00010983" ] }, "reaction_10529557": { "compartment": "compartment_70101", "id": "reaction_10529557", "reactome": "R-CEL-947531", "name": "Molybdenum ion transfer onto molybdopterin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_947561", "species_947496" ], "products": [ "species_111294", "species_947539", "species_76577" ], "modifiers": [ [ "species_10529554", "catalyst" ] ], "additional_components": [ "species_114632", "G5EGH2", "WBGene00003384" ] }, "reaction_10529545": { "compartment": "compartment_70101", "id": "reaction_10529545", "reactome": "R-CEL-947514", "name": "PXLP-K258-NFS1 transfers sulfur from cysteine onto MOCS3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111707", "species_10529529" ], "products": [ "species_10529534", "species_29432" ], "modifiers": [ [ "species_10529542", "catalyst" ] ], "additional_components": [ "species_216785", "O44510", "WBGene00018357", "species_216785", "O44510", "WBGene00018357", "O61741", "WBGene00015021" ] }, "reaction_10513732": { "compartment": "compartment_70101", "id": "reaction_10513732", "reactome": "R-CEL-196950", "name": "2xTRAP hydrolyzes FMN to RIB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_73524" ], "products": [ "species_29372", "species_196931" ], "modifiers": [ [ "species_10513729", "catalyst" ] ], "additional_components": [ "O01320", "WBGene00008531" ] }, "reaction_10513749": { "compartment": "compartment_70101", "id": "reaction_10513749", "reactome": "R-CEL-196955", "name": "2xENPP1 hydrolyzes FAD to FMN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_29386" ], "products": [ "species_73524", "species_76577" ], "modifiers": [ [ "species_10513746", "catalyst" ] ], "additional_components": [ "P90754", "WBGene00007755", "P90755", "WBGene00007755" ] }, "reaction_10513722": { "compartment": "compartment_70101", "id": "reaction_10513722", "reactome": "R-CEL-196929", "name": "FLAD1 phosphorylates FMN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_73524" ], "products": [ "species_111294", "species_29386" ], "modifiers": [ [ "species_10513719", "catalyst" ] ], "additional_components": [ "WBGene00011271" ] }, "reaction_10546475": { "compartment": "compartment_70101", "id": "reaction_10546475", "reactome": "R-CEL-3165230", "name": "SLC52A1,2,3 transport RIB from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_3165253" ], "products": [ "species_196931" ], "modifiers": [ [ "species_10546472", "catalyst" ], [ "species_73524", "inhibitor" ], [ "species_29386", "inhibitor" ] ], "additional_components": [ "G4SDH4", "WBGene00021626", "Q3LFN0", "WBGene00044637" ] }, "reaction_10546433": { "compartment": "compartment_70101", "id": "reaction_10546433", "reactome": "R-CEL-3149519", "name": "MMACHC decyanates CNCbl", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_3149505", "species_10546288" ], "products": [ "species_29366", "species_1130611", "species_10546290" ], "modifiers": [ [ "species_10546288", "catalyst" ] ], "additional_components": [ "WBGene00022766", "Q7Z144", "WBGene00022766", "species_3149479", "WBGene00022766" ] }, "reaction_10546436": { "compartment": "compartment_70101", "id": "reaction_10546436", "reactome": "R-CEL-3149539", "name": "MTR transfers CH3 group from MTHF to cob(I)alamin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200665", "species_10511764" ], "products": [ "species_111355", "species_10511760" ], "modifiers": [ [ "species_10511764", "catalyst" ] ], "additional_components": [ "species_216785", "species_3159260", "Q09582", "WBGene00010988", "species_73524", "Q17574", "WBGene00006510", "species_113596", "species_73524", "Q17574", "WBGene00006510", "species_113596", "species_216785", "CHEBI:28115", "Q09582", "WBGene00010988", "species_216785", "species_3159260", "Q09582", "WBGene00010988", "species_73524", "Q17574", "WBGene00006510", "species_113596" ] }, "reaction_10550725": { "compartment": "compartment_70101", "id": "reaction_10550725", "reactome": "R-CEL-5223313", "name": "ABCD4 may transport Cbl from lysosomal lumen to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_3000239" ], "products": [ "species_29372", "species_3000241", "species_29370" ], "modifiers": [ [ "species_10550722", "catalyst" ] ], "additional_components": [ "WBGene00004060" ] }, "reaction_10546438": { "compartment": "compartment_70101", "id": "reaction_10546438", "reactome": "R-CEL-3149563", "name": "MMADHC targets transport of cytosolic cob(II)alamin to mitochondria", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546415" ], "products": [ "species_3149564", "species_10546417" ], "modifiers": [], "additional_components": [ "Q7Z144", "WBGene00022766", "species_3149479", "Q9XWC9", "WBGene00013577", "Q7Z144", "WBGene00022766", "Q9XWC9", "WBGene00013577" ] }, "reaction_10546504": { "compartment": "compartment_70101", "id": "reaction_10546504", "reactome": "R-CEL-3204318", "name": "cob(II)alamin binds to MTRR:MTR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546425", "species_3149479" ], "products": [ "species_10546427" ], "modifiers": [], "additional_components": [ "species_73524", "Q17574", "WBGene00006510", "species_113596", "species_216785", "Q09582", "WBGene00010988", "species_3149479", "species_73524", "Q17574", "WBGene00006510", "species_113596", "species_216785", "Q09582", "WBGene00010988" ] }, "reaction_10546448": { "compartment": "compartment_5460", "id": "reaction_10546448", "reactome": "R-CEL-3159253", "name": "MMAB transfers adenosyl group from ATP to cob(I)alamin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_3159260", "species_113593" ], "products": [ "species_3159274", "species_3159297" ], "modifiers": [ [ "species_10546445", "catalyst" ] ], "additional_components": [ "Q18218", "WBGene00016144" ] }, "reaction_10546450": { "compartment": "compartment_5460", "id": "reaction_10546450", "reactome": "R-CEL-3159259", "name": "MMAA:MUT binds AdoCbl", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10503659", "species_3159297" ], "products": [ "species_10503661" ], "modifiers": [], "additional_components": [ "Q22111", "WBGene00020169", "Q23381", "WBGene00014202", "species_3159297", "Q22111", "WBGene00020169", "Q23381", "WBGene00014202" ] }, "reaction_10503666": { "compartment": "compartment_5460", "id": "reaction_10503666", "reactome": "R-CEL-71010", "name": "MUT isomerises L-MM-CoA to SUCC-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71009" ], "products": [ "species_70958" ], "modifiers": [ [ "species_10503661", "catalyst" ] ], "additional_components": [ "species_3159297", "Q22111", "WBGene00020169", "Q23381", "WBGene00014202" ] }, "reaction_10546419": { "compartment": "compartment_70101", "id": "reaction_10546419", "reactome": "R-CEL-3149492", "name": "cob(II)alamin dissociates from MMACHC:MMADHC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546415" ], "products": [ "species_3149479", "species_10546417" ], "modifiers": [], "additional_components": [ "Q7Z144", "WBGene00022766", "species_3149479", "Q9XWC9", "WBGene00013577", "Q7Z144", "WBGene00022766", "Q9XWC9", "WBGene00013577" ] }, "reaction_10546293": { "compartment": "compartment_70101", "id": "reaction_10546293", "reactome": "R-CEL-3095889", "name": "MMACHC reduces Cbl", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_3000241", "species_70106", "species_29364", "species_10546288" ], "products": [ "species_29366", "species_10546290" ], "modifiers": [ [ "species_10546288", "catalyst" ] ], "additional_components": [ "WBGene00022766", "Q7Z144", "WBGene00022766", "species_3149479", "WBGene00022766" ] }, "reaction_10546421": { "compartment": "compartment_70101", "id": "reaction_10546421", "reactome": "R-CEL-3149494", "name": "MMACHC:cob(II)alamin binds MMADHC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546413", "species_10546290" ], "products": [ "species_10546415" ], "modifiers": [], "additional_components": [ "WBGene00013577", "Q7Z144", "WBGene00022766", "species_3149479", "Q7Z144", "WBGene00022766", "species_3149479", "Q9XWC9", "WBGene00013577" ] }, "reaction_10546296": { "compartment": "compartment_70101", "id": "reaction_10546296", "reactome": "R-CEL-3095901", "name": "ABCC1 transports cytosolic Cbl to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_3000241", "species_113592" ], "products": [ "species_29372", "species_29370", "species_3000125" ], "modifiers": [ [ "species_10517853", "catalyst" ] ], "additional_components": [ "WBGene00003407" ] }, "reaction_10546430": { "compartment": "compartment_70101", "id": "reaction_10546430", "reactome": "R-CEL-3149518", "name": "MTRR reduces cob(II)alamin to meCbl", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_10546427", "species_71284", "species_29364" ], "products": [ "species_29366", "species_71285", "species_10511760" ], "modifiers": [ [ "species_10546427", "catalyst" ] ], "additional_components": [ "species_3149479", "species_73524", "Q17574", "WBGene00006510", "species_113596", "species_216785", "Q09582", "WBGene00010988", "species_73524", "Q17574", "WBGene00006510", "species_113596", "species_216785", "CHEBI:28115", "Q09582", "WBGene00010988", "species_3149479", "species_73524", "Q17574", "WBGene00006510", "species_113596", "species_216785", "Q09582", "WBGene00010988" ] }, "reaction_10535154": { "compartment": "compartment_70101", "id": "reaction_10535154", "reactome": "R-CEL-1497796", "name": "BH2 binding can lead to eNOS uncoupling", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10515166", "species_1497857" ], "products": [ "species_29870", "species_10535152" ], "modifiers": [], "additional_components": [ "Q9XTG7", "WBGene00000103", "G4S4W1", "WBGene00016980", "Q17941", "WBGene00000102", "species_74016", "Q11083", "WBGene00020378", "P04630", "WBGene00000285", "G5EF37", "WBGene00003934", "A0A2C9C3L3", "WBGene00020378", "Q18136", "WBGene00006861", "Q09665", "WBGene00006583", "O02159", "WBGene00020378", "G5EDZ8", "WBGene00000288", "Q94288", "WBGene00000287", "Q09980", "WBGene00017394", "O16305", "WBGene00000552", "G5EEG0", "WBGene00000286", "Q18688", "WBGene00000915", "species_71185", "species_216785", "species_73524", "species_113596", "species_29870", "Q9XTG7", "WBGene00000103", "G4S4W1", "WBGene00016980", "Q17941", "WBGene00000102", "species_74016", "Q11083", "WBGene00020378", "P04630", "WBGene00000285", "G5EF37", "WBGene00003934", "A0A2C9C3L3", "WBGene00020378", "Q18136", "WBGene00006861", "Q09665", "WBGene00006583", "O02159", "WBGene00020378", "G5EDZ8", "WBGene00000288", "Q94288", "WBGene00000287", "Q09980", "WBGene00017394", "O16305", "WBGene00000552", "G5EEG0", "WBGene00000286", "Q18688", "WBGene00000915", "species_1497857", "species_71185", "species_216785", "species_73524", "species_113596", "species_29870" ] }, "reaction_10534357": { "compartment": "compartment_70101", "id": "reaction_10534357", "reactome": "R-CEL-1474184", "name": "DHNTP is dephosphorylated by PTPS to PTHP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1474124" ], "products": [ "species_1475054", "species_1474179" ], "modifiers": [ [ "species_10534354", "catalyst" ] ], "additional_components": [ "O02058", "WBGene00015010", "species_216785" ] }, "reaction_10534343": { "compartment": "compartment_70101", "id": "reaction_10534343", "reactome": "R-CEL-1474146", "name": "GCH1 reduces GTP to dihydroneopterin triphosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_29356" ], "products": [ "species_1474124", "species_29460" ], "modifiers": [ [ "species_10534331", "catalyst" ], [ "species_29502", "catalyst" ], [ "species_29870", "inhibitor" ], [ "species_10534341", "inhibitor" ] ], "additional_components": [ "Q19980", "WBGene00000298", "D6RYD9", "WBGene00044736", "Q19980", "WBGene00000298" ] }, "reaction_10534712": { "compartment": "compartment_70101", "id": "reaction_10534712", "reactome": "R-CEL-1475422", "name": "PTPS is phosphorylated by cGMP-dependant protein kinase II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10534700", "species_113592" ], "products": [ "species_29370", "species_10534354" ], "modifiers": [ [ "species_10534709", "catalyst" ] ], "additional_components": [ "O02058", "WBGene00015010", "O02058", "WBGene00015010", "species_216785", "H2KYN2", "WBGene00015650", "O76360", "WBGene00001173" ] }, "reaction_10534346": { "compartment": "compartment_70101", "id": "reaction_10534346", "reactome": "R-CEL-1474158", "name": "GCHFR binds to GCH1 and negatively regulates its activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10534331", "species_10534339" ], "products": [ "species_10534341" ], "modifiers": [], "additional_components": [ "Q19980", "WBGene00000298", "D6RYD9", "WBGene00044736", "D6RYD9", "WBGene00044736", "Q19980", "WBGene00000298" ] }, "reaction_10520593": { "compartment": "compartment_70101", "id": "reaction_10520593", "reactome": "R-CEL-389540", "name": "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_389545", "species_29366" ], "products": [ "species_29406", "species_70106", "species_113528", "species_29364" ], "modifiers": [ [ "species_10520590", "catalyst" ] ], "additional_components": [ "H9G2T4", "WBGene00010317" ] }, "reaction_10552560": { "compartment": "compartment_70101", "id": "reaction_10552560", "reactome": "R-CEL-5578910", "name": "KCNK dimers transport K+ from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10552557", "catalyst" ] ], "additional_components": [ "O17185", "WBGene00006318", "Q10937", "WBGene00015137", "Q9NEV3", "WBGene00006696", "G5ECW6", "WBGene00006673" ] }, "reaction_10572199": { "compartment": "compartment_7660", "id": "reaction_10572199", "reactome": "R-CEL-9617927", "name": "FOXO4 binds ATXN3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10556072", "species_10514278" ], "products": [ "species_10572197" ], "modifiers": [], "additional_components": [ "WBGene00006446", "WBGene00000912", "O16850", "WBGene00000912", "O17850", "WBGene00006446" ] }, "reaction_10572203": { "compartment": "compartment_7660", "id": "reaction_10572203", "reactome": "R-CEL-9617996", "name": "FOXO1,FOXO3,FOXO4 bind p-2S-SMAD2/3:SMAD4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10511518", "species_10514274" ], "products": [ "species_10572201" ], "modifiers": [], "additional_components": [ "P45897", "WBGene00004858", "Q21733", "WBGene00000904", "WBGene00000912", "O16850", "WBGene00000912", "P45897", "WBGene00004858", "Q21733", "WBGene00000904" ] }, "reaction_10572288": { "compartment": "compartment_7660", "id": "reaction_10572288", "reactome": "R-CEL-9626928", "name": "CREBBP binds FOXO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10532226", "species_10514274" ], "products": [ "species_10572286" ], "modifiers": [], "additional_components": [ "WBGene00000366", "WBGene00000912", "O16850", "WBGene00000912", "P34545", "WBGene00000366" ] }, "reaction_10572248": { "compartment": "compartment_7660", "id": "reaction_10572248", "reactome": "R-CEL-9620515", "name": "KAT2B,EP300 acetylate FOXO3 under oxidative stress", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113560", "species_10514276" ], "products": [ "species_2485002", "species_10572243" ], "modifiers": [ [ "species_10572245", "catalyst" ], [ "species_3785707", "catalyst" ] ], "additional_components": [ "WBGene00000912", "WBGene00000912", "Q9N3S7", "WBGene00021636" ] }, "reaction_10572251": { "compartment": "compartment_7660", "id": "reaction_10572251", "reactome": "R-CEL-9620532", "name": "SIRT1,SIRT3 deacetylate FOXO3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_427523", "species_10572243" ], "products": [ "species_427497", "species_427498", "species_10514276" ], "modifiers": [ [ "species_10522802", "catalyst" ] ], "additional_components": [ "WBGene00000912", "WBGene00000912", "WBGene00004800" ] }, "reaction_10572161": { "compartment": "compartment_70101", "id": "reaction_10572161", "reactome": "R-CEL-9614423", "name": "14-3-3 proteins bind AKT-phosphorylated FOXO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10572157", "species_10516880" ], "products": [ "species_10572159" ], "modifiers": [], "additional_components": [ "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "WBGene00000912", "O16850", "WBGene00000912", "P41932", "WBGene00003920", "Q20655", "WBGene00001502" ] }, "reaction_10572167": { "compartment": "compartment_70101", "id": "reaction_10572167", "reactome": "R-CEL-9614562", "name": "14-3-3 proteins bind AKT-phosphorylated FOXO3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10572151", "species_10572163" ], "products": [ "species_10572165" ], "modifiers": [], "additional_components": [ "WBGene00000912", "Q20655", "WBGene00001502", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "P41932", "WBGene00003920", "O16850", "WBGene00000912" ] }, "reaction_10572155": { "compartment": "compartment_7660", "id": "reaction_10572155", "reactome": "R-CEL-9614414", "name": "AKT-phosphorylated FOXO1,FOXO3,FOXO4 translocate to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10514285" ], "products": [ "species_10516880" ], "modifiers": [], "additional_components": [ "WBGene00000912", "WBGene00000912" ] }, "reaction_10572171": { "compartment": "compartment_70101", "id": "reaction_10572171", "reactome": "R-CEL-9614564", "name": "14-3-3 proteins bind AKT-phosphorylated FOXO4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10572153", "species_10507059" ], "products": [ "species_10572169" ], "modifiers": [], "additional_components": [ "WBGene00000912", "Q20655", "WBGene00001502", "P41932", "WBGene00003920", "Q20655", "WBGene00001502", "P41932", "WBGene00003920", "O16850", "WBGene00000912" ] }, "reaction_10569079": { "compartment": "compartment_7660", "id": "reaction_10569079", "reactome": "R-CEL-8951966", "name": "EP300 acetylates RUNX3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10569066", "species_113560" ], "products": [ "species_2485002", "species_10569076" ], "modifiers": [ [ "species_10569066", "catalyst" ], [ "species_10511431", "catalyst" ] ], "additional_components": [ "P34545", "WBGene00000366", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "G5EFQ5", "WBGene00004393", "Q95ZL9", "WBGene00000272", "P34545", "WBGene00000366", "P34545", "WBGene00000366", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "G5EBY8", "WBGene00006852", "G5EEL5", "WBGene00000936" ] }, "reaction_10569160": { "compartment": "compartment_7660", "id": "reaction_10569160", "reactome": "R-CEL-8952062", "name": "CCND1 recruits HDAC4 to RUNX3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10549372", "species_10569156" ], "products": [ "species_10569158" ], "modifiers": [], "additional_components": [ "WBGene00001837", "G5EFQ5", "WBGene00004393", "Q95ZL9", "WBGene00000272", "O76561", "WBGene00017423", "Q95Y80", "WBGene00022473", "A0A0K3AWB8", "F57C7.1d", "G5EFQ5", "WBGene00004393", "Q95ZL9", "WBGene00000272", "O76561", "WBGene00017423", "Q95Y80", "WBGene00022473", "A0A0K3AWB8", "F57C7.1d", "O17323", "WBGene00001837" ] }, "reaction_10569165": { "compartment": "compartment_7660", "id": "reaction_10569165", "reactome": "R-CEL-8952069", "name": "HDAC4 deacetylates RUNX3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10569158" ], "products": [ "species_10569098", "species_10569162", "species_427486" ], "modifiers": [ [ "species_10569158", "catalyst" ] ], "additional_components": [ "G5EFQ5", "WBGene00004393", "Q95ZL9", "WBGene00000272", "O76561", "WBGene00017423", "Q95Y80", "WBGene00022473", "A0A0K3AWB8", "F57C7.1d", "O17323", "WBGene00001837", "O76561", "WBGene00017423", "Q95Y80", "WBGene00022473", "A0A0K3AWB8", "F57C7.1d", "O17323", "WBGene00001837", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "G5EFQ5", "WBGene00004393", "Q95ZL9", "WBGene00000272", "O76561", "WBGene00017423", "Q95Y80", "WBGene00022473", "A0A0K3AWB8", "F57C7.1d", "O17323", "WBGene00001837" ] }, "reaction_10569068": { "compartment": "compartment_7660", "id": "reaction_10569068", "reactome": "R-CEL-8951951", "name": "RUNX3 binds EP300", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10566207", "species_10532228" ], "products": [ "species_10569066" ], "modifiers": [], "additional_components": [ "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "WBGene00000366", "P34545", "WBGene00000366", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393" ] }, "reaction_10569102": { "compartment": "compartment_7660", "id": "reaction_10569102", "reactome": "R-CEL-8951977", "name": "Acetylated RUNX3 binds to BRD2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10569098", "species_10569076" ], "products": [ "species_10569100" ], "modifiers": [ [ "species_10549046", "catalyst" ] ], "additional_components": [ "O76561", "WBGene00017423", "Q95Y80", "WBGene00022473", "A0A0K3AWB8", "F57C7.1d", "G5EFQ5", "WBGene00004393", "Q95ZL9", "WBGene00000272", "P34545", "WBGene00000366", "G5EFQ5", "WBGene00004393", "Q95ZL9", "WBGene00000272", "P34545", "WBGene00000366", "O76561", "WBGene00017423", "Q95Y80", "WBGene00022473", "A0A0K3AWB8", "F57C7.1d", "P22981", "WBGene00002335", "species_29438" ] }, "reaction_10570708": { "compartment": "compartment_7660", "id": "reaction_10570708", "reactome": "R-CEL-9008822", "name": "PPM1D dephosphorylates RUNX2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10570700" ], "products": [ "species_10567753", "species_113541" ], "modifiers": [ [ "species_10570705", "catalyst" ] ], "additional_components": [ "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "G5EFQ5", "WBGene00004393", "Q95ZL9", "WBGene00000272", "WBGene00021856" ] }, "reaction_10568512": { "compartment": "compartment_7660", "id": "reaction_10568512", "reactome": "R-CEL-8939706", "name": "SCF(SKP2) polyubiquitinates RUNX2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502318", "species_10568502" ], "products": [ "species_10568507", "species_10502340" ], "modifiers": [ [ "species_10568502", "catalyst" ] ], "additional_components": [ "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "G5EFQ5", "WBGene00004393", "Q23457", "WBGene00004320", "G5ECU1", "WBGene00004807", "Q17389", "WBGene00000836", "WBGene00004393", "Q23457", "WBGene00004320", "G5ECU1", "WBGene00004807", "Q17389", "WBGene00000836", "G5EFQ5", "WBGene00004393", "Q23457", "WBGene00004320", "G5ECU1", "WBGene00004807", "Q17389", "WBGene00000836" ] }, "reaction_10568514": { "compartment": "compartment_7660", "id": "reaction_10568514", "reactome": "R-CEL-8939801", "name": "26S proteasome degrades PolyUb-RUNX2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10568507" ], "products": [ "species_10502318" ], "modifiers": [ [ "species_10512606", "catalyst" ] ], "additional_components": [ "WBGene00004393", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "Q23237", "WBGene00003949", "P90868", "WBGene00003953", "Q9XUV0", "WBGene00003951", "Q966I8", "WBGene00003947", "O62102", "WBGene00003948", "O16368", "WBGene00004502", "Q18787", "WBGene00004501", "O76371", "WBGene00004505", "P46502", "WBGene00004503", "Q9XTT9", "WBGene00004506", "O17071", "WBGene00004504", "Q18115", "WBGene00004459", "Q20938", "WBGene00004462", "Q19324", "WBGene00004461", "Q22253", "WBGene00004465", "Q9GZH5", "WBGene00004458", "Q04908", "WBGene00004460", "O61742", "WBGene00004466", "O76577", "WBGene00004467", "Q20058", "WBGene00009445", "O44156", "WBGene00003927", "Q20585", "WBGene00004463", "Q27488", "WBGene00003923", "O61792", "WBGene00004464", "Q09583", "WBGene00003928", "Q23449", "WBGene00004468", "Q9N599", "WBGene00003924", "Q10920", "WBGene00016623", "Q95008", "WBGene00003926", "Q95PZ7", "WBGene00013435", "O17586", "WBGene00003922", "Q95005", "WBGene00003925", "P34286", "WBGene00003952", "P91477", "WBGene00003950" ] }, "reaction_10570789": { "compartment": "compartment_70101", "id": "reaction_10570789", "reactome": "R-CEL-9009308", "name": "STUB1 polyubiquitinates RUNX2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10570782", "species_10502375" ], "products": [ "species_10570784", "species_10530864" ], "modifiers": [ [ "species_10570782", "catalyst" ] ], "additional_components": [ "G5ECY6", "WBGene00000500", "G5EFQ5", "WBGene00004393", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "WBGene00004393", "WBGene00000500", "G5ECY6", "WBGene00000500", "G5EFQ5", "WBGene00004393" ] }, "reaction_10570791": { "compartment": "compartment_70101", "id": "reaction_10570791", "reactome": "R-CEL-9009309", "name": "RUNX2 binds STUB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10570778", "species_10530864" ], "products": [ "species_10570782" ], "modifiers": [], "additional_components": [ "WBGene00004393", "WBGene00000500", "G5ECY6", "WBGene00000500", "G5EFQ5", "WBGene00004393" ] }, "reaction_10568504": { "compartment": "compartment_7660", "id": "reaction_10568504", "reactome": "R-CEL-8939688", "name": "SCF(SKP2) complex binds RUNX2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502340", "species_10567747" ], "products": [ "species_10568502" ], "modifiers": [], "additional_components": [ "Q23457", "WBGene00004320", "G5ECU1", "WBGene00004807", "Q17389", "WBGene00000836", "WBGene00004393", "G5EFQ5", "WBGene00004393", "Q23457", "WBGene00004320", "G5ECU1", "WBGene00004807", "Q17389", "WBGene00000836" ] }, "reaction_10568390": { "compartment": "compartment_7660", "id": "reaction_10568390", "reactome": "R-CEL-8938356", "name": "RMB14 binds RUNX2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10568386", "species_10567747" ], "products": [ "species_10568388" ], "modifiers": [], "additional_components": [ "WBGene00004384", "WBGene00004393", "G5EFQ5", "WBGene00004393", "Q10667", "WBGene00004384" ] }, "reaction_10567757": { "compartment": "compartment_7660", "id": "reaction_10567757", "reactome": "R-CEL-8877941", "name": "RUNX2 binds SMAD1 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10567753", "species_10567751" ], "products": [ "species_10567755" ], "modifiers": [], "additional_components": [ "G5EFQ5", "WBGene00004393", "Q95ZL9", "WBGene00000272", "F5GUE5", "WBGene00000910", "P45896", "WBGene00004857", "Q02330", "WBGene00004856", "P45897", "WBGene00004858", "F5GUE5", "WBGene00000910", "P45896", "WBGene00004857", "Q02330", "WBGene00004856", "P45897", "WBGene00004858", "G5EFQ5", "WBGene00004393", "Q95ZL9", "WBGene00000272" ] }, "reaction_10570776": { "compartment": "compartment_7660", "id": "reaction_10570776", "reactome": "R-CEL-9009282", "name": "CDK1 phosphorylates RUNX2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10567753" ], "products": [ "species_113582", "species_10570692" ], "modifiers": [ [ "species_10511241", "catalyst" ] ], "additional_components": [ "G5EFQ5", "WBGene00004393", "Q95ZL9", "WBGene00000272", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "O45926", "WBGene00000866", "Q10653", "WBGene00000865", "Q9BLB5", "WBGene00000867", "P34556", "WBGene00000405" ] }, "reaction_10569938": { "compartment": "compartment_7660", "id": "reaction_10569938", "reactome": "R-CEL-8954110", "name": "E2F6:TFDP1:EPC1 binds the PRC2 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10569934", "species_10517100" ], "products": [ "species_10569936" ], "modifiers": [], "additional_components": [ "A5HWA8", "WBGene00001162", "Q22703", "WBGene00001061", "G5EC14", "WBGene00007030", "Q9GYS1", "WBGene00003224", "O17514", "WBGene00003220", "P90916", "WBGene00003036", "P90917", "WBGene00004312", "Q9GYS1", "WBGene00003224", "O17514", "WBGene00003220", "P90916", "WBGene00003036", "P90917", "WBGene00004312", "A5HWA8", "WBGene00001162", "Q22703", "WBGene00001061", "G5EC14", "WBGene00007030" ] }, "reaction_10569925": { "compartment": "compartment_7660", "id": "reaction_10569925", "reactome": "R-CEL-8954056", "name": "E2F6 binds TFDP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10532095", "species_10569808" ], "products": [ "species_10569923" ], "modifiers": [], "additional_components": [ "WBGene00001061", "WBGene00001162", "A5HWA8", "WBGene00001162", "Q22703", "WBGene00001061" ] }, "reaction_10569812": { "compartment": "compartment_7660", "id": "reaction_10569812", "reactome": "R-CEL-8953111", "name": "E2F6 binds TFDP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10532093", "species_10569808" ], "products": [ "species_10569810" ], "modifiers": [], "additional_components": [ "WBGene00001061", "WBGene00001162", "A5HWA8", "WBGene00001162", "Q22703", "WBGene00001061" ] }, "reaction_10569940": { "compartment": "compartment_7660", "id": "reaction_10569940", "reactome": "R-CEL-8954117", "name": "E2F6:TFDP1 binds EPC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10569932", "species_10569810" ], "products": [ "species_10569934" ], "modifiers": [], "additional_components": [ "WBGene00007030", "A5HWA8", "WBGene00001162", "Q22703", "WBGene00001061", "A5HWA8", "WBGene00001162", "Q22703", "WBGene00001061", "G5EC14", "WBGene00007030" ] }, "reaction_10570682": { "compartment": "compartment_7660", "id": "reaction_10570682", "reactome": "R-CEL-9007539", "name": "CHEK1 phosphorylates E2F6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10569808" ], "products": [ "species_113582", "species_10570680" ], "modifiers": [ [ "species_10502788", "catalyst" ] ], "additional_components": [ "WBGene00001162", "WBGene00001162", "WBGene00000498" ] }, "reaction_10569855": { "compartment": "compartment_7660", "id": "reaction_10569855", "reactome": "R-CEL-8953115", "name": "E2F6:TFDP1 binds to MGA:MAX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10569851", "species_10569810" ], "products": [ "species_10569853" ], "modifiers": [], "additional_components": [ "Q23622", "WBGene00006555", "Q8TA81", "WBGene00022695", "Q95PX3", "WBGene00006544", "Q9N2K7", "WBGene00006549", "Q9NA55", "WBGene00006559", "Q9NA56", "WBGene00006558", "Q9NAH2", "WBGene00006553", "Q9TZL0", "WBGene00006550", "Q9U2C9", "WBGene00006556", "Q9XVD5", "WBGene00006557", "O45291", "WBGene00006552", "O61764", "WBGene00006551", "Q20257", "WBGene00006547", "Q22289", "WBGene00006546", "Q22292", "WBGene00006545", "Q18711", "WBGene00003511", "A5HWA8", "WBGene00001162", "Q22703", "WBGene00001061", "A5HWA8", "WBGene00001162", "Q22703", "WBGene00001061", "Q23622", "WBGene00006555", "Q8TA81", "WBGene00022695", "Q95PX3", "WBGene00006544", "Q9N2K7", "WBGene00006549", "Q9NA55", "WBGene00006559", "Q9NA56", "WBGene00006558", "Q9NAH2", "WBGene00006553", "Q9TZL0", "WBGene00006550", "Q9U2C9", "WBGene00006556", "Q9XVD5", "WBGene00006557", "O45291", "WBGene00006552", "O61764", "WBGene00006551", "Q20257", "WBGene00006547", "Q22289", "WBGene00006546", "Q22292", "WBGene00006545", "Q18711", "WBGene00003511" ] }, "reaction_10565458": { "compartment": "compartment_7660", "id": "reaction_10565458", "reactome": "R-CEL-8853965", "name": "VENTX disrupts binding of CTNNB1 (beta-catenin) to TCF4 or LEF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10565454", "species_10565450" ], "products": [ "species_10514938", "species_10565456" ], "modifiers": [], "additional_components": [ "Q10666", "WBGene00004077", "O44326", "WBGene00001979", "WBGene00006380", "WBGene00001979", "Q10666", "WBGene00004077", "Q19937", "WBGene00006380" ] }, "reaction_10567123": { "compartment": "compartment_7660", "id": "reaction_10567123", "reactome": "R-CEL-8871265", "name": "YAP1 binds TEAD4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10532633", "species_10542193" ], "products": [ "species_10567121" ], "modifiers": [], "additional_components": [ "WBGene00008748", "WBGene00001208", "Q19849", "WBGene00001208", "Q19404", "WBGene00008748" ] }, "reaction_10542197": { "compartment": "compartment_7660", "id": "reaction_10542197", "reactome": "R-CEL-2032781", "name": "WWTR1 (TAZ) binds TEAD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10542174", "species_10542183" ], "products": [ "species_10542195" ], "modifiers": [], "additional_components": [ "WBGene00008748", "WBGene00001208", "Q19849", "WBGene00001208", "Q19404", "WBGene00008748" ] }, "reaction_10567127": { "compartment": "compartment_7660", "id": "reaction_10567127", "reactome": "R-CEL-8871266", "name": "YAP1 binds TEAD3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10542191", "species_10532633" ], "products": [ "species_10567125" ], "modifiers": [], "additional_components": [ "WBGene00001208", "WBGene00008748", "Q19404", "WBGene00008748", "Q19849", "WBGene00001208" ] }, "reaction_10542187": { "compartment": "compartment_7660", "id": "reaction_10542187", "reactome": "R-CEL-2032775", "name": "YAP1 binds TEAD1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10532633", "species_10542183" ], "products": [ "species_10542185" ], "modifiers": [], "additional_components": [ "WBGene00008748", "WBGene00001208", "Q19849", "WBGene00001208", "Q19404", "WBGene00008748" ] }, "reaction_10542283": { "compartment": "compartment_7660", "id": "reaction_10542283", "reactome": "R-CEL-2032794", "name": "WWTR1 (TAZ), TBX5, and PCAF form a complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10542174", "species_10542202", "species_10542279" ], "products": [ "species_10542281" ], "modifiers": [], "additional_components": [ "WBGene00008748", "WBGene00021636", "Q9U2C9", "WBGene00006556", "Q95PX3", "WBGene00006544", "O61764", "WBGene00006551", "Q9XVD5", "WBGene00006557", "Q9N2K7", "WBGene00006549", "Q20257", "WBGene00006547", "Q9NA55", "WBGene00006559", "Q22289", "WBGene00006546", "Q9NA56", "WBGene00006558", "Q22292", "WBGene00006545", "Q9NAH2", "WBGene00006553", "Q23622", "WBGene00006555", "Q9TZL0", "WBGene00006550", "Q8TA81", "WBGene00022695", "O45291", "WBGene00006552", "Q9U2C9", "WBGene00006556", "Q95PX3", "WBGene00006544", "O61764", "WBGene00006551", "Q9XVD5", "WBGene00006557", "Q9N2K7", "WBGene00006549", "Q20257", "WBGene00006547", "Q9NA55", "WBGene00006559", "Q22289", "WBGene00006546", "Q9NA56", "WBGene00006558", "Q22292", "WBGene00006545", "Q9NAH2", "WBGene00006553", "Q23622", "WBGene00006555", "Q9TZL0", "WBGene00006550", "Q8TA81", "WBGene00022695", "O45291", "WBGene00006552", "Q9N3S7", "WBGene00021636", "Q19404", "WBGene00008748" ] }, "reaction_10567119": { "compartment": "compartment_7660", "id": "reaction_10567119", "reactome": "R-CEL-8871260", "name": "YAP1 binds TEAD2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10542189", "species_10532633" ], "products": [ "species_10567117" ], "modifiers": [], "additional_components": [ "WBGene00001208", "WBGene00008748", "Q19404", "WBGene00008748", "Q19849", "WBGene00001208" ] }, "reaction_10567590": { "compartment": "compartment_7660", "id": "reaction_10567590", "reactome": "R-CEL-8877192", "name": "RUNX1 binds FOXP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10566201", "species_10567586" ], "products": [ "species_10567588" ], "modifiers": [], "additional_components": [ "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "WBGene00001439", "Q86MF0", "WBGene00001439", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393" ] }, "reaction_10568465": { "compartment": "compartment_7660", "id": "reaction_10568465", "reactome": "R-CEL-8938951", "name": "RUNX1 binds PAX5 (BSAP)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10568461", "species_10566201" ], "products": [ "species_10568463" ], "modifiers": [], "additional_components": [ "G5ED14", "WBGene00001204", "G5EDS1", "WBGene00006870", "Q21263", "WBGene00003938", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "G5ED14", "WBGene00001204", "G5EDS1", "WBGene00006870", "Q21263", "WBGene00003938" ] }, "reaction_10568444": { "compartment": "compartment_7660", "id": "reaction_10568444", "reactome": "R-CEL-8938930", "name": "RUNX1 binds ELF2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10568440", "species_10566201" ], "products": [ "species_10568442" ], "modifiers": [], "additional_components": [ "WBGene00016029", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "H2KYY1", "WBGene00016029" ] }, "reaction_10568259": { "compartment": "compartment_7660", "id": "reaction_10568259", "reactome": "R-CEL-8937022", "name": "PRMT6 arginine methylates H3K4me2-Nucleosome at the THBS1 gene promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10568254", "species_77087" ], "products": [ "species_77502", "species_10568256" ], "modifiers": [ [ "species_10568254", "catalyst" ] ], "additional_components": [ "A5JYW9", "WBGene00004117", "G5ECH0", "WBGene00001836", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "P62784", "WBGene00001875", "Q10453", "WBGene00001945", "K7ZUH9", "WBGene00001914", "A5JYW9", "WBGene00004117", "G5ECH0", "WBGene00001836", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "P62784", "WBGene00001875", "Q10453", "WBGene00001945", "K7ZUH9", "WBGene00001914", "A5JYW9", "WBGene00004117", "G5ECH0", "WBGene00001836", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "P62784", "WBGene00001875", "Q10453", "WBGene00001945", "K7ZUH9", "WBGene00001914" ] }, "reaction_10568275": { "compartment": "compartment_7660", "id": "reaction_10568275", "reactome": "R-CEL-8937113", "name": "PRMT6 arginine methylates H3K4me2-Nucleosome at the MIR27A gene promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10568270", "species_77087" ], "products": [ "species_77502", "species_10568272" ], "modifiers": [ [ "species_10568270", "catalyst" ] ], "additional_components": [ "A5JYW9", "WBGene00004117", "G5ECH0", "WBGene00001836", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "P62784", "WBGene00001875", "Q10453", "WBGene00001945", "K7ZUH9", "WBGene00001914", "A5JYW9", "WBGene00004117", "G5ECH0", "WBGene00001836", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "P62784", "WBGene00001875", "Q10453", "WBGene00001945", "K7ZUH9", "WBGene00001914", "A5JYW9", "WBGene00004117", "G5ECH0", "WBGene00001836", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "P62784", "WBGene00001875", "Q10453", "WBGene00001945", "K7ZUH9", "WBGene00001914" ] }, "reaction_10568130": { "compartment": "compartment_7660", "id": "reaction_10568130", "reactome": "R-CEL-8934735", "name": "PRMT1 arginine-methylates RUNX1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10568121" ], "products": [ "species_77502", "species_10568127" ], "modifiers": [ [ "species_10568121", "catalyst" ] ], "additional_components": [ "Q9U2X0", "WBGene00013766", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "Q95ZL9", "WBGene00000272", "Q9U2X0", "WBGene00013766", "G5EFQ5", "WBGene00004393", "Q9U2X0", "WBGene00013766", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393" ] }, "reaction_10568132": { "compartment": "compartment_7660", "id": "reaction_10568132", "reactome": "R-CEL-8934742", "name": "RUNX1 binds PRMT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10566201", "species_10546564" ], "products": [ "species_10568121" ], "modifiers": [], "additional_components": [ "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "WBGene00013766", "Q9U2X0", "WBGene00013766", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393" ] }, "reaction_10568196": { "compartment": "compartment_7660", "id": "reaction_10568196", "reactome": "R-CEL-8936481", "name": "Core MLL complex methylates H3K4Me2-Nucleosome at the ITGA2B gene promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10568187" ], "products": [ "species_77502", "species_10568193" ], "modifiers": [ [ "species_10568187", "catalyst" ] ], "additional_components": [ "Q10661", "WBGene00001088", "G5EFZ3", "WBGene00012458", "Q09309", "WBGene00017683", "Q18221", "WBGene00004782", "G5EGI1", "WBGene00011729", "Q17963", "WBGene00006474", "P34545", "WBGene00000366", "P28515", "WBGene00001249", "Q9N3S7", "WBGene00021636", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "Q9U2X0", "WBGene00013766", "P62784", "WBGene00001875", "Q10453", "WBGene00001945", "K7ZUH9", "WBGene00001914", "Q10661", "WBGene00001088", "G5EFZ3", "WBGene00012458", "Q09309", "WBGene00017683", "Q18221", "WBGene00004782", "G5EGI1", "WBGene00011729", "Q17963", "WBGene00006474", "P34545", "WBGene00000366", "P28515", "WBGene00001249", "Q9N3S7", "WBGene00021636", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "Q9U2X0", "WBGene00013766", "P62784", "WBGene00001875", "K7ZUH9", "WBGene00001914", "Q10453", "WBGene00001945", "Q10661", "WBGene00001088", "G5EFZ3", "WBGene00012458", "Q09309", "WBGene00017683", "Q18221", "WBGene00004782", "G5EGI1", "WBGene00011729", "Q17963", "WBGene00006474", "P34545", "WBGene00000366", "P28515", "WBGene00001249", "Q9N3S7", "WBGene00021636", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "Q9U2X0", "WBGene00013766", "P62784", "WBGene00001875", "Q10453", "WBGene00001945", "K7ZUH9", "WBGene00001914" ] }, "reaction_10568212": { "compartment": "compartment_7660", "id": "reaction_10568212", "reactome": "R-CEL-8936584", "name": "PRMT6 arginine methylates H3K4me2-Nucleosome at the ITGA2B gene promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10568198" ], "products": [ "species_77502", "species_10568209" ], "modifiers": [ [ "species_10568198", "catalyst" ] ], "additional_components": [ "A5JYW9", "WBGene00004117", "G5ECH0", "WBGene00001836", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "P62784", "WBGene00001875", "Q10453", "WBGene00001945", "K7ZUH9", "WBGene00001914", "A5JYW9", "WBGene00004117", "G5ECH0", "WBGene00001836", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "P62784", "WBGene00001875", "Q10453", "WBGene00001945", "K7ZUH9", "WBGene00001914", "A5JYW9", "WBGene00004117", "G5ECH0", "WBGene00001836", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "P62784", "WBGene00001875", "Q10453", "WBGene00001945", "K7ZUH9", "WBGene00001914" ] }, "reaction_10568228": { "compartment": "compartment_7660", "id": "reaction_10568228", "reactome": "R-CEL-8936621", "name": "Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10568223" ], "products": [ "species_77502", "species_10568225" ], "modifiers": [ [ "species_10568223", "catalyst" ] ], "additional_components": [ "Q10661", "WBGene00001088", "G5EFZ3", "WBGene00012458", "Q09309", "WBGene00017683", "Q18221", "WBGene00004782", "G5EGI1", "WBGene00011729", "Q17963", "WBGene00006474", "P34545", "WBGene00000366", "P28515", "WBGene00001249", "Q9N3S7", "WBGene00021636", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "Q9U2X0", "WBGene00013766", "P62784", "WBGene00001875", "Q10453", "WBGene00001945", "K7ZUH9", "WBGene00001914", "Q10661", "WBGene00001088", "G5EFZ3", "WBGene00012458", "Q09309", "WBGene00017683", "Q18221", "WBGene00004782", "G5EGI1", "WBGene00011729", "Q17963", "WBGene00006474", "P34545", "WBGene00000366", "P28515", "WBGene00001249", "Q9N3S7", "WBGene00021636", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "Q9U2X0", "WBGene00013766", "P62784", "WBGene00001875", "K7ZUH9", "WBGene00001914", "Q10453", "WBGene00001945", "Q10661", "WBGene00001088", "G5EFZ3", "WBGene00012458", "Q09309", "WBGene00017683", "Q18221", "WBGene00004782", "G5EGI1", "WBGene00011729", "Q17963", "WBGene00006474", "P34545", "WBGene00000366", "P28515", "WBGene00001249", "Q9N3S7", "WBGene00021636", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "Q9U2X0", "WBGene00013766", "P62784", "WBGene00001875", "Q10453", "WBGene00001945", "K7ZUH9", "WBGene00001914" ] }, "reaction_10568221": { "compartment": "compartment_7660", "id": "reaction_10568221", "reactome": "R-CEL-8936608", "name": "PRMT6 arginine methylates H3K4me2-Nucleosome at the GP1BA gene promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10568216" ], "products": [ "species_77502", "species_10568218" ], "modifiers": [ [ "species_10568216", "catalyst" ] ], "additional_components": [ "A5JYW9", "WBGene00004117", "G5ECH0", "WBGene00001836", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "P62784", "WBGene00001875", "Q10453", "WBGene00001945", "K7ZUH9", "WBGene00001914", "A5JYW9", "WBGene00004117", "G5ECH0", "WBGene00001836", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "P62784", "WBGene00001875", "Q10453", "WBGene00001945", "K7ZUH9", "WBGene00001914", "A5JYW9", "WBGene00004117", "G5ECH0", "WBGene00001836", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "P62784", "WBGene00001875", "Q10453", "WBGene00001945", "K7ZUH9", "WBGene00001914" ] }, "reaction_10568252": { "compartment": "compartment_7660", "id": "reaction_10568252", "reactome": "R-CEL-8937016", "name": "Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10568247" ], "products": [ "species_77502", "species_10568249" ], "modifiers": [ [ "species_10568247", "catalyst" ] ], "additional_components": [ "Q10661", "WBGene00001088", "G5EFZ3", "WBGene00012458", "Q09309", "WBGene00017683", "Q18221", "WBGene00004782", "G5EGI1", "WBGene00011729", "Q17963", "WBGene00006474", "P34545", "WBGene00000366", "P28515", "WBGene00001249", "Q9N3S7", "WBGene00021636", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "Q9U2X0", "WBGene00013766", "P62784", "WBGene00001875", "Q10453", "WBGene00001945", "K7ZUH9", "WBGene00001914", "Q10661", "WBGene00001088", "G5EFZ3", "WBGene00012458", "Q09309", "WBGene00017683", "Q18221", "WBGene00004782", "G5EGI1", "WBGene00011729", "Q17963", "WBGene00006474", "P34545", "WBGene00000366", "P28515", "WBGene00001249", "Q9N3S7", "WBGene00021636", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "Q9U2X0", "WBGene00013766", "P62784", "WBGene00001875", "K7ZUH9", "WBGene00001914", "Q10453", "WBGene00001945", "Q10661", "WBGene00001088", "G5EFZ3", "WBGene00012458", "Q09309", "WBGene00017683", "Q18221", "WBGene00004782", "G5EGI1", "WBGene00011729", "Q17963", "WBGene00006474", "P34545", "WBGene00000366", "P28515", "WBGene00001249", "Q9N3S7", "WBGene00021636", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "Q9U2X0", "WBGene00013766", "P62784", "WBGene00001875", "Q10453", "WBGene00001945", "K7ZUH9", "WBGene00001914" ] }, "reaction_10568268": { "compartment": "compartment_7660", "id": "reaction_10568268", "reactome": "R-CEL-8937050", "name": "Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10568263" ], "products": [ "species_77502", "species_10568265" ], "modifiers": [ [ "species_10568263", "catalyst" ] ], "additional_components": [ "Q10661", "WBGene00001088", "G5EFZ3", "WBGene00012458", "Q09309", "WBGene00017683", "Q18221", "WBGene00004782", "G5EGI1", "WBGene00011729", "Q17963", "WBGene00006474", "P34545", "WBGene00000366", "P28515", "WBGene00001249", "Q9N3S7", "WBGene00021636", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "Q9U2X0", "WBGene00013766", "P62784", "WBGene00001875", "Q10453", "WBGene00001945", "K7ZUH9", "WBGene00001914", "Q10661", "WBGene00001088", "G5EFZ3", "WBGene00012458", "Q09309", "WBGene00017683", "Q18221", "WBGene00004782", "G5EGI1", "WBGene00011729", "Q17963", "WBGene00006474", "P34545", "WBGene00000366", "P28515", "WBGene00001249", "Q9N3S7", "WBGene00021636", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "Q9U2X0", "WBGene00013766", "P62784", "WBGene00001875", "K7ZUH9", "WBGene00001914", "Q10453", "WBGene00001945", "Q10661", "WBGene00001088", "G5EFZ3", "WBGene00012458", "Q09309", "WBGene00017683", "Q18221", "WBGene00004782", "G5EGI1", "WBGene00011729", "Q17963", "WBGene00006474", "P34545", "WBGene00000366", "P28515", "WBGene00001249", "Q9N3S7", "WBGene00021636", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "Q9U2X0", "WBGene00013766", "P62784", "WBGene00001875", "Q10453", "WBGene00001945", "K7ZUH9", "WBGene00001914" ] }, "reaction_10567792": { "compartment": "compartment_7660", "id": "reaction_10567792", "reactome": "R-CEL-8878050", "name": "HIPK2 phosphorylates RUNX1 and EP300", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10567776" ], "products": [ "species_113582", "species_10567789" ], "modifiers": [ [ "species_10549016", "catalyst" ] ], "additional_components": [ "P34545", "WBGene00000366", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "P34545", "WBGene00000366", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "WBGene00001994" ] }, "reaction_10567794": { "compartment": "compartment_7660", "id": "reaction_10567794", "reactome": "R-CEL-8878054", "name": "HIPK2 phosphorylates RUNX1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10566201" ], "products": [ "species_113582", "species_10567787" ], "modifiers": [ [ "species_10549016", "catalyst" ] ], "additional_components": [ "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "WBGene00001994" ] }, "reaction_10567796": { "compartment": "compartment_7660", "id": "reaction_10567796", "reactome": "R-CEL-8878056", "name": "RUNX1:CBFB binds EP300", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10566201", "species_10532228" ], "products": [ "species_10567776" ], "modifiers": [], "additional_components": [ "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "WBGene00000366", "P34545", "WBGene00000366", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393" ] }, "reaction_10568377": { "compartment": "compartment_7660", "id": "reaction_10568377", "reactome": "R-CEL-8938217", "name": "RUNX1 binds the SWI/SNF complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10546652", "species_10566201" ], "products": [ "species_10568375" ], "modifiers": [], "additional_components": [ "H8ESF3", "WBGene00004203", "Q21831", "WBGene00011111", "G5EF53", "WBGene00004204", "P91094", "WBGene00004106", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "H8ESF3", "WBGene00004203", "Q21831", "WBGene00011111", "G5EF53", "WBGene00004204", "P91094", "WBGene00004106" ] }, "reaction_10570134": { "compartment": "compartment_7660", "id": "reaction_10570134", "reactome": "R-CEL-8956639", "name": "RUNX1 binds YAP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10532633", "species_10566201" ], "products": [ "species_10570132" ], "modifiers": [ [ "species_10555896", "inhibitor" ] ], "additional_components": [ "WBGene00008748", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "Q19404", "WBGene00008748", "WBGene00000018" ] }, "reaction_10570141": { "compartment": "compartment_7660", "id": "reaction_10570141", "reactome": "R-CEL-8956659", "name": "ABL1 phosphorylates YAP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10532633" ], "products": [ "species_113582", "species_10570138" ], "modifiers": [ [ "species_10555896", "catalyst" ] ], "additional_components": [ "WBGene00008748", "WBGene00008748", "WBGene00000018" ] }, "reaction_10568381": { "compartment": "compartment_7660", "id": "reaction_10568381", "reactome": "R-CEL-8938231", "name": "RUNX1:CBFB binds CREBBP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10566201", "species_10532226" ], "products": [ "species_10568379" ], "modifiers": [], "additional_components": [ "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393", "WBGene00000366", "P34545", "WBGene00000366", "Q95ZL9", "WBGene00000272", "G5EFQ5", "WBGene00004393" ] }, "reaction_10552368": { "compartment": "compartment_7660", "id": "reaction_10552368", "reactome": "R-CEL-5444523", "name": "Formation of MSH1:PMS2 Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10551625", "species_10551620" ], "products": [ "species_10551627" ], "modifiers": [], "additional_components": [ "WBGene00004064", "WBGene00003373", "Q9XU10", "WBGene00003373", "G5EFG5", "WBGene00004064" ] }, "reaction_10551667": { "compartment": "compartment_7660", "id": "reaction_10551667", "reactome": "R-CEL-5358597", "name": "EXO1 interacts with MSH2:MSH6 (MutSalpha) and MLH1:PMS2 (MutLalpha)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10551663", "species_10551647" ], "products": [ "species_10551665" ], "modifiers": [], "additional_components": [ "WBGene00009731", "Q9TXR4", "WBGene00003418", "Q9N3T8", "WBGene00003422", "species_29358", "Q9XU10", "WBGene00003373", "G5EFG5", "WBGene00004064", "O02115", "WBGene00003955", "Q9TXR4", "WBGene00003418", "Q9N3T8", "WBGene00003422", "species_29358", "Q9XU10", "WBGene00003373", "G5EFG5", "WBGene00004064", "O02115", "WBGene00003955", "O62245", "WBGene00009731" ] }, "reaction_10551650": { "compartment": "compartment_7660", "id": "reaction_10551650", "reactome": "R-CEL-5358518", "name": "MLH1:PMS2 makes single strand incision near 1-2 base mismatch", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10551643" ], "products": [ "species_10551647" ], "modifiers": [ [ "species_10551643", "catalyst" ] ], "additional_components": [ "Q9TXR4", "WBGene00003418", "Q9N3T8", "WBGene00003422", "species_29358", "Q9XU10", "WBGene00003373", "G5EFG5", "WBGene00004064", "O02115", "WBGene00003955", "Q9TXR4", "WBGene00003418", "Q9N3T8", "WBGene00003422", "species_29358", "Q9XU10", "WBGene00003373", "G5EFG5", "WBGene00004064", "O02115", "WBGene00003955", "Q9TXR4", "WBGene00003418", "Q9N3T8", "WBGene00003422", "species_29358", "Q9XU10", "WBGene00003373", "G5EFG5", "WBGene00004064", "O02115", "WBGene00003955" ] }, "reaction_10551669": { "compartment": "compartment_7660", "id": "reaction_10551669", "reactome": "R-CEL-5358912", "name": "MSH2:MSH6 exchanges ADP for ATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10551654" ], "products": [ "species_113582", "species_10551641" ], "modifiers": [], "additional_components": [ "Q9TXR4", "WBGene00003418", "Q9N3T8", "WBGene00003422", "species_113582", "Q9TXR4", "WBGene00003418", "Q9N3T8", "WBGene00003422", "species_29358" ] }, "reaction_10551656": { "compartment": "compartment_7660", "id": "reaction_10551656", "reactome": "R-CEL-5358525", "name": "MSH2:MSH6 binds 1 base mismatch or 1-2 base insertion/deletion loop", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10551652", "species_5358514" ], "products": [ "species_10551654" ], "modifiers": [], "additional_components": [ "Q9TXR4", "WBGene00003418", "Q9N3T8", "WBGene00003422", "species_113582", "Q9TXR4", "WBGene00003418", "Q9N3T8", "WBGene00003422", "species_113582" ] }, "reaction_10551645": { "compartment": "compartment_7660", "id": "reaction_10551645", "reactome": "R-CEL-5358510", "name": "MSH2:MSH6 recruits MLH1:PMS2 to mismatch and interacts with PCNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502653", "species_10551627", "species_10551641" ], "products": [ "species_10551643" ], "modifiers": [], "additional_components": [ "O02115", "WBGene00003955", "Q9XU10", "WBGene00003373", "G5EFG5", "WBGene00004064", "Q9TXR4", "WBGene00003418", "Q9N3T8", "WBGene00003422", "species_29358", "Q9TXR4", "WBGene00003418", "Q9N3T8", "WBGene00003422", "species_29358", "Q9XU10", "WBGene00003373", "G5EFG5", "WBGene00004064", "O02115", "WBGene00003955" ] }, "reaction_10552366": { "compartment": "compartment_7660", "id": "reaction_10552366", "reactome": "R-CEL-5444516", "name": "Formation of MSH2:MSH6 Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113582", "species_10551637", "species_10551632" ], "products": [ "species_10551652" ], "modifiers": [], "additional_components": [ "WBGene00003422", "WBGene00003418", "Q9TXR4", "WBGene00003418", "Q9N3T8", "WBGene00003422", "species_113582" ] }, "reaction_10521473": { "compartment": "compartment_70101", "id": "reaction_10521473", "reactome": "R-CEL-399951", "name": "Phosphorylation of CRMPs by GSK3beta", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10521396" ], "products": [ "species_10521470", "species_29370" ], "modifiers": [ [ "species_10513574", "catalyst" ] ], "additional_components": [ "O45657", "WBGene00004048", "U4PRY7", "WBGene00004047", "G5ECH7", "WBGene00000407", "Q22695", "WBGene00011955", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q18677", "WBGene00000964", "Q21773", "WBGene00000963", "Q01630", "WBGene00006769", "Q95XP4", "WBGene00003111", "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "Q95XP4", "WBGene00003111", "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "O45657", "WBGene00004048", "U4PRY7", "WBGene00004047", "Q18677", "WBGene00000964", "Q21773", "WBGene00000963", "Q01630", "WBGene00006769", "G5ECH7", "WBGene00000407", "Q22695", "WBGene00011955", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q9U2Q9", "WBGene00001746", "Q09595", "WBGene00010991", "Q93372", "WBGene00010991" ] }, "reaction_10521399": { "compartment": "compartment_70101", "id": "reaction_10521399", "reactome": "R-CEL-399944", "name": "Phosphorylation of CRMPs by Cdk5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10521323", "species_113592", "species_10521345" ], "products": [ "species_29370", "species_10521396" ], "modifiers": [ [ "species_10521345", "catalyst" ] ], "additional_components": [ "Q18677", "WBGene00000964", "Q21773", "WBGene00000963", "Q01630", "WBGene00006769", "Q95XP4", "WBGene00003111", "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "O45657", "WBGene00004048", "U4PRY7", "WBGene00004047", "G5ECH7", "WBGene00000407", "Q22695", "WBGene00011955", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "O45657", "WBGene00004048", "U4PRY7", "WBGene00004047", "G5ECH7", "WBGene00000407", "Q22695", "WBGene00011955", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q18677", "WBGene00000964", "Q21773", "WBGene00000963", "Q01630", "WBGene00006769", "Q95XP4", "WBGene00003111", "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "Q95XP4", "WBGene00003111", "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "O45657", "WBGene00004048", "U4PRY7", "WBGene00004047", "G5ECH7", "WBGene00000407", "Q22695", "WBGene00011955", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635" ] }, "reaction_10521435": { "compartment": "compartment_70101", "id": "reaction_10521435", "reactome": "R-CEL-399947", "name": "Tyrosine phosphorylation of CRMPs by Fes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10521323", "species_113592", "species_10521204" ], "products": [ "species_29370", "species_10521432" ], "modifiers": [ [ "species_10516270", "catalyst" ] ], "additional_components": [ "Q18677", "WBGene00000964", "Q21773", "WBGene00000963", "Q01630", "WBGene00006769", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "U4PRY7", "WBGene00004047", "O45657", "WBGene00004048", "Q95XP4", "WBGene00003111", "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "O01325", "WBGene00009160", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "U4PRY7", "WBGene00004047", "O45657", "WBGene00004048", "Q95XP4", "WBGene00003111", "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "O01325", "WBGene00009160", "Q21773", "WBGene00000963", "Q01630", "WBGene00006769", "Q18677", "WBGene00000964", "WBGene00009160" ] }, "reaction_10503744": { "compartment": "compartment_70101", "id": "reaction_10503744", "reactome": "R-CEL-71130", "name": "q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_71129", "species_73473" ], "products": [ "species_29870", "species_29360" ], "modifiers": [ [ "species_10503741", "catalyst" ] ], "additional_components": [ "Q9XVJ3", "WBGene00011398" ] }, "reaction_10503734": { "compartment": "compartment_70101", "id": "reaction_10503734", "reactome": "R-CEL-71118", "name": "PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29870", "species_29502", "species_29368" ], "products": [ "species_71112", "species_29506" ], "modifiers": [ [ "species_10503731", "catalyst" ] ], "additional_components": [ "P90925", "WBGene00000240", "species_113531" ] }, "reaction_10528409": { "compartment": "compartment_70101", "id": "reaction_10528409", "reactome": "R-CEL-893593", "name": "phenylalanine + pyruvate => 3-(indol-3-yl)pyruvate + alanine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29502", "species_29398" ], "products": [ "species_29432", "species_893599" ], "modifiers": [ [ "species_10528406", "catalyst" ] ], "additional_components": [ "Q9XX97", "WBGene00009232", "Q8MP09", "WBGene00010984" ] }, "reaction_10503754": { "compartment": "compartment_70101", "id": "reaction_10503754", "reactome": "R-CEL-71146", "name": "4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71112" ], "products": [ "species_29356", "species_71129" ], "modifiers": [ [ "species_10503751", "catalyst" ] ], "additional_components": [ "Q9TZH6", "WBGene00020397" ] }, "reaction_10507618": { "compartment": "compartment_17951", "id": "reaction_10507618", "reactome": "R-CEL-76031", "name": "2 H2O2 => O2 + 2 H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113575" ], "products": [ "species_113535", "species_141343" ], "modifiers": [ [ "species_10507615", "catalyst" ] ], "additional_components": [ "species_71185", "species_29364", "Q8MYL7", "WBGene00013220" ] }, "reaction_10548068": { "compartment": "compartment_17927", "id": "reaction_10548068", "reactome": "R-CEL-3777112", "name": "SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_3341308", "species_163953" ], "products": [ "species_189481", "species_189461" ], "modifiers": [ [ "species_10548065", "catalyst" ] ], "additional_components": [ "species_209799", "species_216785", "P34697", "WBGene00004930", "Q27538", "WBGene00007036" ] }, "reaction_10547432": { "compartment": "compartment_5460", "id": "reaction_10547432", "reactome": "R-CEL-3323079", "name": "GSR catalyzes glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113529", "species_1655882", "species_113600" ], "products": [ "species_113563", "species_1655887" ], "modifiers": [ [ "species_10547429", "catalyst" ] ], "additional_components": [ "Q93379", "WBGene00008117", "species_113596" ] }, "reaction_10549770": { "compartment": "compartment_17963", "id": "reaction_10549770", "reactome": "R-CEL-4837364", "name": "Secretion of SOD3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10549768" ], "products": [ "species_10547194" ], "modifiers": [], "additional_components": [ "P34697", "WBGene00004930", "species_216785", "species_209799", "species_216785", "P34697", "WBGene00004930", "species_209799" ] }, "reaction_10547467": { "compartment": "compartment_70101", "id": "reaction_10547467", "reactome": "R-CEL-3343700", "name": "PRDX6:GSTP1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29450", "species_29408" ], "products": [ "species_29356", "species_111745" ], "modifiers": [ [ "species_10547464", "catalyst" ] ], "additional_components": [ "Q8MXT1", "WBGene00021401", "P10299", "WBGene00001749" ] }, "reaction_10547212": { "compartment": "compartment_70101", "id": "reaction_10547212", "reactome": "R-CEL-3299691", "name": "SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_1222424" ], "products": [ "species_29368", "species_29408" ], "modifiers": [ [ "species_10547209", "catalyst" ] ], "additional_components": [ "species_216785", "species_209799", "P34697", "WBGene00004930", "Q27538", "WBGene00007036" ] }, "reaction_10547438": { "compartment": "compartment_70616", "id": "reaction_10547438", "reactome": "R-CEL-3341294", "name": "Superoxide reduces cytochrome c", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10510159", "species_3341308" ], "products": [ "species_10510157", "species_189461" ], "modifiers": [], "additional_components": [ "CHEBI:38574", "P19974", "WBGene00017121", "Q23240", "WBGene00013854", "CHEBI:38573", "P19974", "WBGene00017121", "Q23240", "WBGene00013854" ] }, "reaction_10547186": { "compartment": "compartment_5460", "id": "reaction_10547186", "reactome": "R-CEL-3299680", "name": "SOD2 catalyzes 2H+ + 2O2.- => O2 + H2O2 (mitochondrial matrix)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113529", "species_3299683" ], "products": [ "species_113533", "species_1614617" ], "modifiers": [ [ "species_10547183", "catalyst" ] ], "additional_components": [ "species_266099", "P31161", "WBGene00004931" ] }, "reaction_10547411": { "compartment": "compartment_5460", "id": "reaction_10547411", "reactome": "R-CEL-3322995", "name": "PRDX3,5 catalyze TXN2 reduced + H2O2 => TXN2 oxidized + 2H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10547396", "species_1614617" ], "products": [ "species_10547399", "species_113521" ], "modifiers": [ [ "species_10547408", "catalyst" ] ], "additional_components": [ "WBGene00007099", "WBGene00007099", "Q21824", "WBGene00011110" ] }, "reaction_10557597": { "compartment": "compartment_5460", "id": "reaction_10557597", "reactome": "R-CEL-5696197", "name": "NUDT2 hydrolyses GP4G to GTP, GMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5696199", "species_113521" ], "products": [ "species_5696194", "species_113573" ], "modifiers": [ [ "species_10557594", "catalyst" ] ], "additional_components": [ "WBGene00003581" ] }, "reaction_10547197": { "compartment": "compartment_984", "id": "reaction_10547197", "reactome": "R-CEL-3299682", "name": "SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_3299686" ], "products": [ "species_351629", "species_352327" ], "modifiers": [ [ "species_10547194", "catalyst" ] ], "additional_components": [ "species_216785", "P34697", "WBGene00004930", "species_209799" ] }, "reaction_10547423": { "compartment": "compartment_5460", "id": "reaction_10547423", "reactome": "R-CEL-3323050", "name": "TXNRD2 catalyzes the reduction of TXN2 by NADPH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113529", "species_10547399", "species_113600" ], "products": [ "species_113563", "species_10547396" ], "modifiers": [ [ "species_10547420", "catalyst" ] ], "additional_components": [ "WBGene00007099", "WBGene00007099", "P30635", "WBGene00014028", "species_113596" ] }, "reaction_10502803": { "compartment": "compartment_7660", "id": "reaction_10502803", "reactome": "R-CEL-69608", "name": "Phosphorylation of Cdc25A at Ser-123 by Chk2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10502759" ], "products": [ "species_113582", "species_10502781" ], "modifiers": [ [ "species_10502800", "catalyst" ] ], "additional_components": [ "WBGene00000389", "WBGene00000389", "WBGene00000499" ] }, "reaction_10502779": { "compartment": "compartment_70101", "id": "reaction_10502779", "reactome": "R-CEL-69600", "name": "Proteolytic degradation of ubiquitinated-Cdc25A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502777" ], "products": [ "species_10502375" ], "modifiers": [ [ "species_10502572", "catalyst" ] ], "additional_components": [ "Q21762", "WBGene00000389", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "P91477", "WBGene00003950", "Q95PZ7", "WBGene00013435", "Q18115", "WBGene00004459", "O62102", "WBGene00003948", "O17071", "WBGene00004504", "Q10920", "WBGene00016623", "P34286", "WBGene00003952", "Q9XTT9", "WBGene00004506", "Q23449", "WBGene00004468", "Q95005", "WBGene00003925", "P46502", "WBGene00004503", "O61792", "WBGene00004464", "O17586", "WBGene00003922", "O76371", "WBGene00004505", "Q20585", "WBGene00004463", "Q95008", "WBGene00003926", "Q18787", "WBGene00004501", "Q20058", "WBGene00009445", "Q9N599", "WBGene00003924", "O16368", "WBGene00004502", "O61742", "WBGene00004466", "Q09583", "WBGene00003928", "Q966I8", "WBGene00003947", "Q04908", "WBGene00004460", "Q9XUV0", "WBGene00003951", "Q27488", "WBGene00003923", "Q9GZH5", "WBGene00004458", "O44156", "WBGene00003927", "Q22253", "WBGene00004465", "O76577", "WBGene00004467", "P90868", "WBGene00003953", "Q19324", "WBGene00004461", "Q17971", "WBGene00007588", "Q23237", "WBGene00003949", "Q20938", "WBGene00004462" ] }, "reaction_10557688": { "compartment": "compartment_7660", "id": "reaction_10557688", "reactome": "R-CEL-5696655", "name": "PARP1 or PARP2 PARylates DDB2 and autoPARylates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10557686", "species_427523" ], "products": [ "species_427497", "species_10556156" ], "modifiers": [], "additional_components": [ "Q21554", "WBGene00010890", "Q23457", "WBGene00004320", "Q17392", "WBGene00000839", "P30644", "WBGene00011145", "Q23451", "WBGene00013924", "Q9N4C3", "WBGene00022296", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "Q23457", "WBGene00004320", "Q17392", "WBGene00000839", "Q21554", "WBGene00010890", "P30644", "WBGene00011145", "Q23451", "WBGene00013924", "Q9N4C3", "WBGene00022296", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725" ] }, "reaction_10556733": { "compartment": "compartment_7660", "id": "reaction_10556733", "reactome": "R-CEL-5691004", "name": "XPC binds RAD23 and CETN2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10549311", "species_10556067", "species_10549280" ], "products": [ "species_10556731" ], "modifiers": [], "additional_components": [ "WBGene00022296", "WBGene00013924", "WBGene00011145", "P30644", "WBGene00011145", "Q23451", "WBGene00013924", "Q9N4C3", "WBGene00022296" ] }, "reaction_10556781": { "compartment": "compartment_7660", "id": "reaction_10556781", "reactome": "R-CEL-5691006", "name": "XPC:RAD23:CETN2 and UV-DDB bind distorted dsDNA site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10556731", "species_10556777", "species_5688114" ], "products": [ "species_10556779", "species_10556775" ], "modifiers": [], "additional_components": [ "P30644", "WBGene00011145", "Q23451", "WBGene00013924", "Q9N4C3", "WBGene00022296", "Q21554", "WBGene00010890", "Q23457", "WBGene00004320", "Q17392", "WBGene00000839", "Q9GS00", "WBGene00000813", "Q9N359", "WBGene00000816", "P91001", "WBGene00000817", "O01422", "WBGene00000814", "Q9N425", "WBGene00000815", "Q95PZ0", "WBGene00000818", "Q21554", "WBGene00010890", "Q23457", "WBGene00004320", "Q17392", "WBGene00000839", "P30644", "WBGene00011145", "Q23451", "WBGene00013924", "Q9N4C3", "WBGene00022296", "Q9GS00", "WBGene00000813", "Q9N359", "WBGene00000816", "P91001", "WBGene00000817", "O01422", "WBGene00000814", "Q9N425", "WBGene00000815", "Q95PZ0", "WBGene00000818" ] }, "reaction_10557965": { "compartment": "compartment_7660", "id": "reaction_10557965", "reactome": "R-CEL-6782943", "name": "UV-DDB ubiquitinates XPC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502318", "species_10556779" ], "products": [ "species_10557684" ], "modifiers": [ [ "species_10556779", "catalyst" ] ], "additional_components": [ "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "Q21554", "WBGene00010890", "Q23457", "WBGene00004320", "Q17392", "WBGene00000839", "P30644", "WBGene00011145", "Q23451", "WBGene00013924", "Q9N4C3", "WBGene00022296", "Q21554", "WBGene00010890", "Q23457", "WBGene00004320", "Q17392", "WBGene00000839", "P30644", "WBGene00011145", "Q23451", "WBGene00013924", "Q9N4C3", "WBGene00022296", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "Q21554", "WBGene00010890", "Q23457", "WBGene00004320", "Q17392", "WBGene00000839", "P30644", "WBGene00011145", "Q23451", "WBGene00013924", "Q9N4C3", "WBGene00022296" ] }, "reaction_10537696": { "compartment": "compartment_876", "id": "reaction_10537696", "reactome": "R-CEL-1855213", "name": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_994170" ], "products": [ "species_29372", "species_994123" ], "modifiers": [ [ "species_10537691", "catalyst" ] ], "additional_components": [ "WBGene00007620" ] }, "reaction_10537745": { "compartment": "compartment_876", "id": "reaction_10537745", "reactome": "R-CEL-1855221", "name": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_179856" ], "products": [ "species_114520", "species_114519" ], "modifiers": [ [ "species_10537742", "catalyst" ] ], "additional_components": [ "G5EFI8", "WBGene00004036", "species_74016", "Q22070", "WBGene00004038" ] }, "reaction_10537729": { "compartment": "compartment_70101", "id": "reaction_10537729", "reactome": "R-CEL-1855218", "name": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_994170" ], "products": [ "species_29372", "species_994123" ], "modifiers": [ [ "species_10537603", "catalyst" ] ], "additional_components": [ "O17590", "WBGene00007620", "P34370", "WBGene00086546", "G5ECL2", "WBGene00006763" ] }, "reaction_10537619": { "compartment": "compartment_70101", "id": "reaction_10537619", "reactome": "R-CEL-1855177", "name": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_179856" ], "products": [ "species_114520", "species_114519" ], "modifiers": [ [ "species_10537616", "catalyst" ] ], "additional_components": [ "species_74016", "G5EBH0", "WBGene00001177" ] }, "reaction_10537513": { "compartment": "compartment_70101", "id": "reaction_10537513", "reactome": "R-CEL-1855153", "name": "I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by ITPKA/B/C in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_114520" ], "products": [ "species_29370", "species_994170" ], "modifiers": [ [ "species_10537510", "catalyst" ] ], "additional_components": [ "species_74016", "Q95Q62", "WBGene00002979", "Q11083", "WBGene00020378", "P04630", "WBGene00000285", "G5EF37", "WBGene00003934", "A0A2C9C3L3", "WBGene00020378", "Q18136", "WBGene00006861", "Q09665", "WBGene00006583", "O02159", "WBGene00020378", "G5EDZ8", "WBGene00000288", "Q94288", "WBGene00000287", "Q09980", "WBGene00017394", "O16305", "WBGene00000552", "G5EEG0", "WBGene00000286" ] }, "reaction_10537723": { "compartment": "compartment_12045", "id": "reaction_10537723", "reactome": "R-CEL-1855214", "name": "PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2023856", "species_29356" ], "products": [ "species_114520", "species_1500596" ], "modifiers": [ [ "species_10537720", "catalyst" ] ], "additional_components": [ "Q8I4C7", "WBGene00020256", "H2KZ05", "WBGene00020256", "O17405", "WBGene00017316", "Q19056", "WBGene00020256", "species_74016" ] }, "reaction_10537677": { "compartment": "compartment_70101", "id": "reaction_10537677", "reactome": "R-CEL-1855205", "name": "I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_994170" ], "products": [ "species_29372", "species_114520" ], "modifiers": [ [ "species_10537674", "catalyst" ] ], "additional_components": [ "species_114632", "G5EE01", "WBGene00000913" ] }, "reaction_10572147": { "compartment": "compartment_12045", "id": "reaction_10572147", "reactome": "R-CEL-9614271", "name": "Autocleavage of ADGRG6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10572138" ], "products": [ "species_10572144" ], "modifiers": [ [ "species_10572138", "catalyst" ] ], "additional_components": [ "WBGene00017947", "Q19930", "WBGene00017947", "WBGene00017947" ] }, "reaction_10572149": { "compartment": "compartment_876", "id": "reaction_10572149", "reactome": "R-CEL-9614273", "name": "ADGRG heterodimer translocates to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10572144" ], "products": [ "species_10572144" ], "modifiers": [], "additional_components": [ "Q19930", "WBGene00017947", "Q19930", "WBGene00017947" ] }, "reaction_10519185": { "compartment": "compartment_984", "id": "reaction_10519185", "reactome": "R-CEL-375160", "name": "NCAM1 binds to ATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_114570", "species_10518758" ], "products": [ "species_10519183" ], "modifiers": [], "additional_components": [ "WBGene00004372", "C6KRM7", "WBGene00004372", "species_29358" ] }, "reaction_10519181": { "compartment": "compartment_984", "id": "reaction_10519181", "reactome": "R-CEL-375151", "name": "Interaction of NCAM1 with collagens", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10519177", "species_10518758" ], "products": [ "species_10519179" ], "modifiers": [], "additional_components": [ "Q9N4U2", "WBGene00000647", "O76368", "WBGene00000674", "Q09457", "WBGene00000251", "P17140", "WBGene00002280", "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689", "WBGene00004372", "C6KRM7", "WBGene00004372", "Q9N4U2", "WBGene00000647", "O76368", "WBGene00000674", "Q09457", "WBGene00000251", "P17140", "WBGene00002280", "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689" ] }, "reaction_10520993": { "compartment": "compartment_70101", "id": "reaction_10520993", "reactome": "R-CEL-392054", "name": "NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10512175", "species_29438" ], "products": [ "species_29420", "species_10511481" ], "modifiers": [ [ "species_10520988", "catalyst" ] ], "additional_components": [ "species_29420", "P22981", "WBGene00002335", "species_29438", "P22981", "WBGene00002335", "E0AHA7", "WBGene00006803", "G5EFW3", "WBGene00004855", "Q21408", "WBGene00004951", "Q7YZG5", "WBGene00021702", "C6KRM7", "WBGene00004372", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "P29355", "WBGene00004774", "Q9N5D3", "WBGene00004947", "Q95YD4", "WBGene00002213" ] }, "reaction_10520984": { "compartment": "compartment_70101", "id": "reaction_10520984", "reactome": "R-CEL-392051", "name": "Recruitment of Grb2 to pFAK:NCAM1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10506871", "species_10520978" ], "products": [ "species_10520982" ], "modifiers": [], "additional_components": [ "WBGene00004774", "E0AHA7", "WBGene00006803", "G5EFW3", "WBGene00004855", "Q21408", "WBGene00004951", "Q7YZG5", "WBGene00021702", "C6KRM7", "WBGene00004372", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q95YD4", "WBGene00002213", "E0AHA7", "WBGene00006803", "G5EFW3", "WBGene00004855", "Q21408", "WBGene00004951", "Q7YZG5", "WBGene00021702", "C6KRM7", "WBGene00004372", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "P29355", "WBGene00004774", "Q95YD4", "WBGene00002213" ] }, "reaction_10520990": { "compartment": "compartment_70101", "id": "reaction_10520990", "reactome": "R-CEL-392053", "name": "SOS binds Grb2 bound to pFAK:NCAM1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10506876", "species_10520982" ], "products": [ "species_10520988" ], "modifiers": [], "additional_components": [ "WBGene00004947", "E0AHA7", "WBGene00006803", "G5EFW3", "WBGene00004855", "Q21408", "WBGene00004951", "Q7YZG5", "WBGene00021702", "C6KRM7", "WBGene00004372", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "P29355", "WBGene00004774", "Q95YD4", "WBGene00002213", "E0AHA7", "WBGene00006803", "G5EFW3", "WBGene00004855", "Q21408", "WBGene00004951", "Q7YZG5", "WBGene00021702", "C6KRM7", "WBGene00004372", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "P29355", "WBGene00004774", "Q9N5D3", "WBGene00004947", "Q95YD4", "WBGene00002213" ] }, "reaction_10570819": { "compartment": "compartment_984", "id": "reaction_10570819", "reactome": "R-CEL-9010815", "name": "SLITs bind keratan sulfate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10519315", "species_2299699" ], "products": [ "species_10570817" ], "modifiers": [], "additional_components": [ "WBGene00004854", "species_2299699", "G5EFX6", "WBGene00004854" ] }, "reaction_10523182": { "compartment": "compartment_876", "id": "reaction_10523182", "reactome": "R-CEL-428518", "name": "Glypican-1 (GPC1) binds SLIT2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10523178", "species_10519315" ], "products": [ "species_10523180" ], "modifiers": [], "additional_components": [ "G5EGU4", "WBGene00001687", "Q18530", "WBGene00003056", "CHEBI:17421", "WBGene00004854", "G5EFX6", "WBGene00004854", "G5EGU4", "WBGene00001687", "Q18530", "WBGene00003056", "CHEBI:17421" ] }, "reaction_10571295": { "compartment": "compartment_984", "id": "reaction_10571295", "reactome": "R-CEL-9014812", "name": "ROBOs bind keratan sulfate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10523160", "species_2299699" ], "products": [ "species_10571293" ], "modifiers": [], "additional_components": [ "WBGene00004732", "species_2299699", "Q53U87", "WBGene00004732" ] }, "reaction_10521289": { "compartment": "compartment_70101", "id": "reaction_10521289", "reactome": "R-CEL-399939", "name": "Autophosphorylation of PAK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10521208" ], "products": [ "species_29370", "species_10521286" ], "modifiers": [ [ "species_10521208", "catalyst" ] ], "additional_components": [ "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "species_29438", "Q03206", "ced-10", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "U4PRY7", "WBGene00004047", "O45657", "WBGene00004048", "Q95XP4", "WBGene00003111", "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "O01325", "WBGene00009160", "Q17850", "WBGene00003911", "G5EGQ3", "WBGene00003144", "species_29438", "Q03206", "ced-10", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "U4PRY7", "WBGene00004047", "O45657", "WBGene00004048", "Q95XP4", "WBGene00003111", "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "O01325", "WBGene00009160", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "species_29438", "Q03206", "ced-10", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "U4PRY7", "WBGene00004047", "O45657", "WBGene00004048", "Q95XP4", "WBGene00003111", "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "O01325", "WBGene00009160" ] }, "reaction_10521210": { "compartment": "compartment_70101", "id": "reaction_10521210", "reactome": "R-CEL-399930", "name": "Activation of PAK by Rac1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10520686", "species_10521206" ], "products": [ "species_10521208", "species_10520688" ], "modifiers": [], "additional_components": [ "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "species_29438", "Q03206", "ced-10", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "U4PRY7", "WBGene00004047", "O45657", "WBGene00004048", "Q95XP4", "WBGene00003111", "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "O01325", "WBGene00009160", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "species_29438", "Q03206", "ced-10", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "U4PRY7", "WBGene00004047", "O45657", "WBGene00004048", "Q95XP4", "WBGene00003111", "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "O01325", "WBGene00009160", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911" ] }, "reaction_10521249": { "compartment": "compartment_876", "id": "reaction_10521249", "reactome": "R-CEL-399933", "name": "Sema3A binds Nrp-1 bound to PlexinA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10521243", "species_10521174" ], "products": [ "species_10521247", "species_10521239" ], "modifiers": [], "additional_components": [ "O45657", "WBGene00004048", "U4PRY7", "WBGene00004047", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "O17905", "WBGene00001490", "Q95XP4", "WBGene00003111", "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "Q95XP4", "WBGene00003111", "Q9TYS4", "WBGene00004890", "Q17330", "WBGene00004889", "O45657", "WBGene00004048", "U4PRY7", "WBGene00004047", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "WBGene00001490" ] }, "reaction_10521260": { "compartment": "compartment_70101", "id": "reaction_10521260", "reactome": "R-CEL-399936", "name": "Inhibition of integrin activation by sequestering PIP5KIgamma", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10521256", "species_10521239" ], "products": [ "species_10521258", "species_10518194" ], "modifiers": [], "additional_components": [ "G5EGK1", "WBGene00006771", "O01759", "WBGene00004087", "WBGene00001490", "O01759", "WBGene00004087", "O17905", "WBGene00001490", "WBGene00006771" ] }, "reaction_10521608": { "compartment": "compartment_70101", "id": "reaction_10521608", "reactome": "R-CEL-416588", "name": "Activation of Rho by LARG and PDZ-RhoGEF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10521599", "species_29438" ], "products": [ "species_29420", "species_10509488" ], "modifiers": [ [ "species_10521605", "catalyst" ] ], "additional_components": [ "species_29420", "Q22038", "WBGene00004357", "Q22038", "WBGene00004357", "species_29438", "P24348", "WBGene00002299", "O45657", "WBGene00004048", "U4PRY7", "WBGene00004047", "Q17330", "WBGene00004889", "Q95XP4", "WBGene00003111", "Q9TYS4", "WBGene00004890", "G5EFE1", "WBGene00006468", "H2L0P5", "WBGene00022391" ] }, "reaction_10521610": { "compartment": "compartment_70101", "id": "reaction_10521610", "reactome": "R-CEL-416594", "name": "LARG and PDZ-RhoGEF binds to Plexin-B1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10521603", "species_10521601" ], "products": [ "species_10521605" ], "modifiers": [], "additional_components": [ "G5EFE1", "WBGene00006468", "H2L0P5", "WBGene00022391", "P24348", "WBGene00002299", "O45657", "WBGene00004048", "U4PRY7", "WBGene00004047", "Q17330", "WBGene00004889", "Q95XP4", "WBGene00003111", "Q9TYS4", "WBGene00004890", "P24348", "WBGene00002299", "O45657", "WBGene00004048", "U4PRY7", "WBGene00004047", "Q17330", "WBGene00004889", "Q95XP4", "WBGene00003111", "Q9TYS4", "WBGene00004890", "G5EFE1", "WBGene00006468", "H2L0P5", "WBGene00022391" ] }, "reaction_10518622": { "compartment": "compartment_70101", "id": "reaction_10518622", "reactome": "R-CEL-373750", "name": "SEMA4D interacts with Plexin-B1:ErbB2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10518607", "species_10518591", "species_113592" ], "products": [ "species_10518619", "species_29370" ], "modifiers": [ [ "species_10518607", "catalyst" ] ], "additional_components": [ "P24348", "WBGene00002299", "O45657", "WBGene00004048", "U4PRY7", "WBGene00004047", "Q17330", "WBGene00004889", "Q95XP4", "WBGene00003111", "Q9TYS4", "WBGene00004890", "P24348", "WBGene00002299", "O45657", "WBGene00004048", "U4PRY7", "WBGene00004047", "Q17330", "WBGene00004889", "Q95XP4", "WBGene00003111", "Q9TYS4", "WBGene00004890", "P24348", "WBGene00002299", "O45657", "WBGene00004048", "U4PRY7", "WBGene00004047" ] }, "reaction_10521585": { "compartment": "compartment_70101", "id": "reaction_10521585", "reactome": "R-CEL-416546", "name": "Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10521574" ], "products": [ "species_29372", "species_10521576" ], "modifiers": [ [ "species_10521582", "catalyst" ] ], "additional_components": [ "G5EBK8", "WBGene00004310", "species_29438", "species_29420", "G5EBK8", "WBGene00004310", "Q9XVQ7", "WBGene00008711", "O45657", "WBGene00004048", "U4PRY7", "WBGene00004047", "Q17330", "WBGene00004889", "Q95XP4", "WBGene00003111", "Q9TYS4", "WBGene00004890", "species_29438" ] }, "reaction_10521963": { "compartment": "compartment_70101", "id": "reaction_10521963", "reactome": "R-CEL-419646", "name": "SEMA4D interacts with Plexin-B1:Met", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10518591", "species_113592", "species_10521960" ], "products": [ "species_29370", "species_10521546" ], "modifiers": [ [ "species_10521960", "catalyst" ] ], "additional_components": [ "Q17330", "WBGene00004889", "Q95XP4", "WBGene00003111", "Q9TYS4", "WBGene00004890", "Q9XVQ7", "WBGene00008711", "O45657", "WBGene00004048", "U4PRY7", "WBGene00004047", "Q9XVQ7", "WBGene00008711", "O45657", "WBGene00004048", "U4PRY7", "WBGene00004047", "Q17330", "WBGene00004889", "Q95XP4", "WBGene00003111", "Q9TYS4", "WBGene00004890", "Q9XVQ7", "WBGene00008711", "O45657", "WBGene00004048", "U4PRY7", "WBGene00004047" ] }, "reaction_10521595": { "compartment": "compartment_70101", "id": "reaction_10521595", "reactome": "R-CEL-416559", "name": "Inactivation of Rho-GTP by p190RhoGAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10509488" ], "products": [ "species_10509486", "species_29372" ], "modifiers": [ [ "species_10521592", "catalyst" ] ], "additional_components": [ "Q22038", "WBGene00004357", "species_29438", "Q22038", "WBGene00004357", "species_29420", "O45611", "WBGene00010374", "Q9XVQ7", "WBGene00008711", "O45657", "WBGene00004048", "U4PRY7", "WBGene00004047", "Q17330", "WBGene00004889", "Q95XP4", "WBGene00003111", "Q9TYS4", "WBGene00004890", "species_29438" ] }, "reaction_10521597": { "compartment": "compartment_70101", "id": "reaction_10521597", "reactome": "R-CEL-416562", "name": "p190RhoGAP binds Plexin-B1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10521582", "species_10521590" ], "products": [ "species_10521592" ], "modifiers": [], "additional_components": [ "Q9XVQ7", "WBGene00008711", "O45657", "WBGene00004048", "U4PRY7", "WBGene00004047", "Q17330", "WBGene00004889", "Q95XP4", "WBGene00003111", "Q9TYS4", "WBGene00004890", "species_29438", "WBGene00010374", "O45611", "WBGene00010374", "Q9XVQ7", "WBGene00008711", "O45657", "WBGene00004048", "U4PRY7", "WBGene00004047", "Q17330", "WBGene00004889", "Q95XP4", "WBGene00003111", "Q9TYS4", "WBGene00004890", "species_29438" ] }, "reaction_10521550": { "compartment": "compartment_70101", "id": "reaction_10521550", "reactome": "R-CEL-400682", "name": "Active Rac1 interacts with Plexin-B1:Sema4D", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10521546", "species_10509457" ], "products": [ "species_10521548" ], "modifiers": [], "additional_components": [ "Q9XVQ7", "WBGene00008711", "O45657", "WBGene00004048", "U4PRY7", "WBGene00004047", "Q17330", "WBGene00004889", "Q95XP4", "WBGene00003111", "Q9TYS4", "WBGene00004890", "species_29438", "Q03206", "ced-10", "species_29438", "Q03206", "ced-10", "Q9XVQ7", "WBGene00008711", "O45657", "WBGene00004048", "U4PRY7", "WBGene00004047", "Q17330", "WBGene00004889", "Q95XP4", "WBGene00003111", "Q9TYS4", "WBGene00004890" ] }, "reaction_10518688": { "compartment": "compartment_876", "id": "reaction_10518688", "reactome": "R-CEL-374663", "name": "DCC interaction with Ezrin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10518684", "species_10518486" ], "products": [ "species_10518686" ], "modifiers": [], "additional_components": [ "species_179856", "G5EBK3", "WBGene00001333", "G5EF96", "phospho-unc-40", "species_179856", "G5EBK3", "WBGene00001333" ] }, "reaction_10518706": { "compartment": "compartment_70101", "id": "reaction_10518706", "reactome": "R-CEL-374667", "name": "DCC interaction with SIAH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10518702", "species_10518499" ], "products": [ "species_10518704" ], "modifiers": [], "additional_components": [ "WBGene00021369", "P34710", "unc-6", "G5EF96", "phospho-unc-40", "P34710", "unc-6", "G5EF96", "phospho-unc-40", "Q965X6", "WBGene00021369" ] }, "reaction_10518691": { "compartment": "compartment_70101", "id": "reaction_10518691", "reactome": "R-CEL-374664", "name": "Phosphorylation and activation of Ezrin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10518677" ], "products": [ "species_10518684", "species_29370" ], "modifiers": [ [ "species_10515209", "catalyst" ] ], "additional_components": [ "species_179856", "G5EBK3", "WBGene00001333", "species_179856", "G5EBK3", "WBGene00001333", "WBGene00006599" ] }, "reaction_10518533": { "compartment": "compartment_70101", "id": "reaction_10518533", "reactome": "R-CEL-373716", "name": "DCC interacting NCK-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10518510", "species_10518529" ], "products": [ "species_10518531" ], "modifiers": [], "additional_components": [ "WBGene00006410", "P34710", "unc-6", "G5EF96", "phospho-unc-40", "Q95YD4", "WBGene00002213", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "P34710", "unc-6", "G5EF96", "phospho-unc-40", "Q95YD4", "WBGene00002213", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q95PX0", "WBGene00006410" ] }, "reaction_10521893": { "compartment": "compartment_70101", "id": "reaction_10521893", "reactome": "R-CEL-418850", "name": "Activation of Cdc42", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10520579", "species_10521888" ], "products": [ "species_29420", "species_10521890" ], "modifiers": [ [ "species_10521888", "catalyst" ] ], "additional_components": [ "Q05062", "WBGene00000390", "species_29420", "P34710", "unc-6", "G5EF96", "phospho-unc-40", "Q95YD4", "WBGene00002213", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q95PX0", "WBGene00006410", "G5EEN3", "WBGene00000419", "P34710", "unc-6", "G5EF96", "phospho-unc-40", "Q95YD4", "WBGene00002213", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q95PX0", "WBGene00006410", "G5EEN3", "WBGene00000419", "Q05062", "WBGene00000390", "species_29438", "P34710", "unc-6", "G5EF96", "phospho-unc-40", "Q95YD4", "WBGene00002213", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q95PX0", "WBGene00006410", "G5EEN3", "WBGene00000419" ] }, "reaction_10518503": { "compartment": "compartment_876", "id": "reaction_10518503", "reactome": "R-CEL-373707", "name": "Netrin-1 induced DCC clustering", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10518486", "species_10518499" ], "products": [ "species_10518501" ], "modifiers": [], "additional_components": [ "P34710", "unc-6", "G5EF96", "phospho-unc-40", "P34710", "unc-6", "G5EF96", "phospho-unc-40" ] }, "reaction_10518505": { "compartment": "compartment_984", "id": "reaction_10518505", "reactome": "R-CEL-373711", "name": "DCC interaction with Netrin-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10518486", "species_10518497" ], "products": [ "species_10518499" ], "modifiers": [], "additional_components": [ "P34710", "unc-6", "G5EF96", "phospho-unc-40" ] }, "reaction_10521899": { "compartment": "compartment_70101", "id": "reaction_10521899", "reactome": "R-CEL-418858", "name": "RhoGTPase GEF's recruited to DCC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10521886", "species_10518531" ], "products": [ "species_10521888" ], "modifiers": [], "additional_components": [ "WBGene00000419", "P34710", "unc-6", "G5EF96", "phospho-unc-40", "Q95YD4", "WBGene00002213", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q95PX0", "WBGene00006410", "P34710", "unc-6", "G5EF96", "phospho-unc-40", "Q95YD4", "WBGene00002213", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "Q95PX0", "WBGene00006410", "G5EEN3", "WBGene00000419" ] }, "reaction_10521901": { "compartment": "compartment_70101", "id": "reaction_10521901", "reactome": "R-CEL-418868", "name": "Recruitment of Src and Fyn to DCC:FADK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10518527", "species_10518770" ], "products": [ "species_10518772" ], "modifiers": [], "additional_components": [ "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "P34710", "unc-6", "G5EF96", "phospho-unc-40", "Q95YD4", "WBGene00002213", "P34710", "unc-6", "G5EF96", "phospho-unc-40", "Q95YD4", "WBGene00002213", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635" ] }, "reaction_10518781": { "compartment": "compartment_70101", "id": "reaction_10518781", "reactome": "R-CEL-374701", "name": "Phosphorylation of DCC by Fyn", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10518772" ], "products": [ "species_29370", "species_10518529" ], "modifiers": [ [ "species_10518772", "catalyst" ] ], "additional_components": [ "P34710", "unc-6", "G5EF96", "phospho-unc-40", "Q95YD4", "WBGene00002213", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "P34710", "unc-6", "G5EF96", "phospho-unc-40", "Q95YD4", "WBGene00002213", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "P34710", "unc-6", "G5EF96", "phospho-unc-40", "Q95YD4", "WBGene00002213", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635" ] }, "reaction_10519264": { "compartment": "compartment_876", "id": "reaction_10519264", "reactome": "R-CEL-376122", "name": "DSCAM/DSCAML1 homodimerization", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10519260" ], "products": [ "species_10519262" ], "modifiers": [], "additional_components": [ "Q18806", "WBGene00004370", "H2KZ60", "WBGene00016354", "Q18806", "WBGene00004370", "H2KZ60", "WBGene00016354" ] }, "reaction_10526129": { "compartment": "compartment_70101", "id": "reaction_10526129", "reactome": "R-CEL-451347", "name": "Activation of JNK by DSCAM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10510931" ], "products": [ "species_29370", "species_10510951" ], "modifiers": [ [ "species_10519282", "catalyst" ] ], "additional_components": [ "WBGene00002178", "WBGene00002178", "species_29438", "Q03206", "ced-10", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "Q18806", "WBGene00004370", "H2KZ60", "WBGene00016354" ] }, "reaction_10519284": { "compartment": "compartment_70101", "id": "reaction_10519284", "reactome": "R-CEL-376123", "name": "DSCAM associates with Rac1-GTP:pPAK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10519252", "species_10519280" ], "products": [ "species_10519282" ], "modifiers": [], "additional_components": [ "Q18806", "WBGene00004370", "H2KZ60", "WBGene00016354", "species_29438", "Q03206", "ced-10", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "species_29438", "Q03206", "ced-10", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "Q18806", "WBGene00004370", "H2KZ60", "WBGene00016354" ] }, "reaction_10526154": { "compartment": "compartment_70101", "id": "reaction_10526154", "reactome": "R-CEL-451366", "name": "Activation of p38MAPK by DSCAM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10526151" ], "products": [ "species_29370", "species_10512658" ], "modifiers": [ [ "species_10519282", "catalyst" ] ], "additional_components": [ "Q17446", "WBGene00004055", "Q8MXI4", "WBGene00004056", "species_114632", "Q17446", "WBGene00004055", "Q8MXI4", "WBGene00004056", "species_114632", "species_29438", "Q03206", "ced-10", "G5EGQ3", "WBGene00003144", "Q17850", "WBGene00003911", "Q18806", "WBGene00004370", "H2KZ60", "WBGene00016354" ] }, "reaction_10518679": { "compartment": "compartment_70101", "id": "reaction_10518679", "reactome": "R-CEL-374662", "name": "Translocation of Ezrin to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10518675", "species_179856" ], "products": [ "species_10518677" ], "modifiers": [], "additional_components": [ "WBGene00001333", "species_179856", "G5EBK3", "WBGene00001333" ] }, "reaction_10527529": { "compartment": "compartment_876", "id": "reaction_10527529", "reactome": "R-CEL-593685", "name": "Netrin-4 binds DCC/UNC5A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10527518", "species_10527525" ], "products": [ "species_10527527" ], "modifiers": [], "additional_components": [ "WBGene00002247", "Q26261", "WBGene00006745", "G5EF96", "phospho-unc-40", "Q26261", "WBGene00006745", "G5EF96", "phospho-unc-40", "O44565", "WBGene00002247" ] }, "reaction_10518700": { "compartment": "compartment_70101", "id": "reaction_10518700", "reactome": "R-CEL-374665", "name": "DCC interaction with SIAH1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10518696", "species_10518499" ], "products": [ "species_10518698" ], "modifiers": [], "additional_components": [ "WBGene00021369", "P34710", "unc-6", "G5EF96", "phospho-unc-40", "P34710", "unc-6", "G5EF96", "phospho-unc-40", "Q965X6", "WBGene00021369" ] }, "reaction_10518727": { "compartment": "compartment_70101", "id": "reaction_10518727", "reactome": "R-CEL-374673", "name": "L1 binds RanBPM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10518718", "species_10518723" ], "products": [ "species_10518725" ], "modifiers": [], "additional_components": [ "Q21465", "WBGene00019727", "Q5WRR1", "WBGene00006942", "WBGene00013202", "Q9XWK4", "WBGene00013202", "Q21465", "WBGene00019727", "Q5WRR1", "WBGene00006942" ] }, "reaction_10518546": { "compartment": "compartment_876", "id": "reaction_10518546", "reactome": "R-CEL-373730", "name": "Neurofascin and NrCAM heterodimerization", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10518542", "species_10518540" ], "products": [ "species_10518544" ], "modifiers": [], "additional_components": [ "WBGene00004732", "WBGene00004732", "Q53U87", "WBGene00004732" ] }, "reaction_10515214": { "compartment": "compartment_876", "id": "reaction_10515214", "reactome": "R-CEL-202222", "name": "Phosphorylation of PKC theta", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10515204" ], "products": [ "species_10515211", "species_29370" ], "modifiers": [ [ "species_10515195", "catalyst" ] ], "additional_components": [ "P34722", "WBGene00006599", "species_112275", "species_112275", "P34722", "WBGene00006599", "Q9UA62", "WBGene00021022", "species_202247", "species_179838" ] }, "reaction_10508214": { "compartment": "compartment_5460", "id": "reaction_10508214", "reactome": "R-CEL-77271", "name": "3-Oxotetradecanoyl-CoA+CoA-SH<=>Lauroyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_77269" ], "products": [ "species_77261", "species_113559" ], "modifiers": [ [ "species_10508211", "catalyst" ] ], "additional_components": [ "P34255", "WBGene00015125", "Q9GYT0", "WBGene00020347" ] }, "reaction_10508217": { "compartment": "compartment_5460", "id": "reaction_10508217", "reactome": "R-CEL-77277", "name": "trans-Tetradec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxytetradecanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77273", "species_113521" ], "products": [ "species_77276" ], "modifiers": [ [ "species_10508211", "catalyst" ] ], "additional_components": [ "P34255", "WBGene00015125", "Q9GYT0", "WBGene00020347" ] }, "reaction_10508220": { "compartment": "compartment_5460", "id": "reaction_10508220", "reactome": "R-CEL-77283", "name": "(S)-3-Hydroxytetradecanoyl-CoA+NAD<=>3-Oxotetradecanoyl-CoA+NADH+H", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77276", "species_113526" ], "products": [ "species_113529", "species_77269", "species_29362" ], "modifiers": [ [ "species_10508211", "catalyst" ] ], "additional_components": [ "P34255", "WBGene00015125", "Q9GYT0", "WBGene00020347" ] }, "reaction_10510256": { "compartment": "compartment_70101", "id": "reaction_10510256", "reactome": "R-CEL-163764", "name": "D-fructose 6-phosphate + D-erythrose 4-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29512", "species_29878" ], "products": [ "species_29578", "species_29882" ], "modifiers": [ [ "species_10503949", "catalyst" ] ], "additional_components": [ "Q966C7", "WBGene00021286" ] }, "reaction_10510242": { "compartment": "compartment_70101", "id": "reaction_10510242", "reactome": "R-CEL-163741", "name": "D-glyceraldehyde 3-phosphate + sedoheptulose 7-phosphate<=> xylulose 5-phosphate+ribose 5-phosphate ", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29882", "species_29578" ], "products": [ "species_29790", "species_73578" ], "modifiers": [ [ "species_10503939", "catalyst" ] ], "additional_components": [ "O17759", "WBGene00008506", "species_114632", "species_8878387" ] }, "reaction_10510252": { "compartment": "compartment_70101", "id": "reaction_10510252", "reactome": "R-CEL-163751", "name": "D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate <=> xylulose 5-phosphate + D-erythrose 4-phosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29578", "species_29512" ], "products": [ "species_29790", "species_29878" ], "modifiers": [ [ "species_10503939", "catalyst" ] ], "additional_components": [ "O17759", "WBGene00008506", "species_114632", "species_8878387" ] }, "reaction_10513329": { "compartment": "compartment_984", "id": "reaction_10513329", "reactome": "R-CEL-192417", "name": "Digestion of cholesterol esters by extracellular CEL (bile salt-dependent lipase)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_171076" ], "products": [ "species_171149", "species_174602" ], "modifiers": [ [ "species_10513326", "catalyst" ] ], "additional_components": [ "CHEBI:17687", "CHEBI:28865", "CHEBI:16755", "CHEBI:36274", "species_193451", "CHEBI:9407", "Q20826", "WBGene00018878", "Q9XTG1", "WBGene00006412" ] }, "reaction_10513332": { "compartment": "compartment_984", "id": "reaction_10513332", "reactome": "R-CEL-192425", "name": "Digestion of monoacylglycerols by extracellular CEL (bile salt-dependent lipase)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_6814795" ], "products": [ "species_174602", "species_192438" ], "modifiers": [ [ "species_10513326", "catalyst" ] ], "additional_components": [ "CHEBI:17687", "CHEBI:28865", "CHEBI:16755", "CHEBI:36274", "species_193451", "CHEBI:9407", "Q20826", "WBGene00018878", "Q9XTG1", "WBGene00006412" ] }, "reaction_10513334": { "compartment": "compartment_984", "id": "reaction_10513334", "reactome": "R-CEL-192430", "name": "Digestion of triacylglycerols by extracellular CEL (bile salt-dependent lipase)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_171126" ], "products": [ "species_174602", "species_174675" ], "modifiers": [ [ "species_10513326", "catalyst" ] ], "additional_components": [ "CHEBI:17687", "CHEBI:28865", "CHEBI:16755", "CHEBI:36274", "species_193451", "CHEBI:9407", "Q20826", "WBGene00018878", "Q9XTG1", "WBGene00006412" ] }, "reaction_10570265": { "compartment": "compartment_984", "id": "reaction_10570265", "reactome": "R-CEL-8979996", "name": "LIPs hydrolyze TG to DAG and LCFA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_171126" ], "products": [ "species_174602", "species_174675" ], "modifiers": [ [ "species_10570262", "catalyst" ] ], "additional_components": [] }, "reaction_10554517": { "compartment": "compartment_70101", "id": "reaction_10554517", "reactome": "R-CEL-5661256", "name": "AKR1A1 reduces D-glucuronate to L-gulonate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_5661264", "species_29364" ], "products": [ "species_29366", "species_5661268" ], "modifiers": [ [ "species_10554514", "catalyst" ] ], "additional_components": [ "WBGene00012722" ] }, "reaction_10554535": { "compartment": "compartment_70101", "id": "reaction_10554535", "reactome": "R-CEL-5662466", "name": "XYLB phosphorylates D-xylulose", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_5661281" ], "products": [ "species_29790", "species_29370" ], "modifiers": [ [ "species_10554532", "catalyst" ] ], "additional_components": [ "WBGene00011147" ] }, "reaction_10554538": { "compartment": "compartment_70101", "id": "reaction_10554538", "reactome": "R-CEL-5662471", "name": "SORD tetramer oxidizes xylitol to D-xylulose", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5660033", "species_29360" ], "products": [ "species_70106", "species_5661281", "species_73473" ], "modifiers": [ [ "species_10554251", "catalyst" ] ], "additional_components": [ "species_216785", "Q21702", "WBGene00011003" ] }, "reaction_10554509": { "compartment": "compartment_70101", "id": "reaction_10554509", "reactome": "R-CEL-5661240", "name": "DCXR tetramer reduces L-xylulose to xylitol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_5660036" ], "products": [ "species_5660033", "species_29366" ], "modifiers": [ [ "species_10554506", "catalyst" ] ], "additional_components": [ "Q21929", "WBGene00000984" ] }, "reaction_10554527": { "compartment": "compartment_70101", "id": "reaction_10554527", "reactome": "R-CEL-5661290", "name": "CRYL1 dimer dehydrogenates L-gulonate to 3-dehydro-L-gulonate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5661268", "species_29360" ], "products": [ "species_70106", "species_5661262", "species_73473" ], "modifiers": [ [ "species_10554524", "catalyst" ] ], "additional_components": [ "C0VXV5", "WBGene00022130" ] }, "reaction_10543520": { "compartment": "compartment_984", "id": "reaction_10543520", "reactome": "R-CEL-2213201", "name": "Formation of collagen fibres", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10534604" ], "products": [ "species_10543518" ], "modifiers": [], "additional_components": [ "Q9N4U2", "WBGene00000647", "O76368", "WBGene00000674", "Q09457", "WBGene00000251", "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689", "P17140", "WBGene00002280", "Q21437", "WBGene00000659", "Q9N4U2", "WBGene00000647", "O76368", "WBGene00000674", "Q09457", "WBGene00000251", "P17140", "WBGene00002280", "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689", "Q21437", "WBGene00000659" ] }, "reaction_10543796": { "compartment": "compartment_984", "id": "reaction_10543796", "reactome": "R-CEL-2299620", "name": "Collagen XI cross-links with collagen II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10517286", "species_10534598" ], "products": [ "species_10543794" ], "modifiers": [], "additional_components": [ "O76368", "WBGene00000674", "Q09457", "WBGene00000251", "Q9N4U2", "WBGene00000647", "O76368", "WBGene00000674", "Q09457", "WBGene00000251", "Q9N4U2", "WBGene00000647", "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689", "O76368", "WBGene00000674", "Q09457", "WBGene00000251", "Q9N4U2", "WBGene00000647", "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689" ] }, "reaction_10543528": { "compartment": "compartment_984", "id": "reaction_10543528", "reactome": "R-CEL-2213207", "name": "Formation of collagen networks", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10543522" ], "products": [ "species_10543526" ], "modifiers": [], "additional_components": [ "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689", "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689" ] }, "reaction_10544002": { "compartment": "compartment_984", "id": "reaction_10544002", "reactome": "R-CEL-2395223", "name": "Formation of hydroxylysyl-pyridinoline cross-links", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10543979" ], "products": [ "species_10544000" ], "modifiers": [], "additional_components": [ "Q9N4U2", "WBGene00000647", "Q9N4U2", "WBGene00000647" ] }, "reaction_10544004": { "compartment": "compartment_984", "id": "reaction_10544004", "reactome": "R-CEL-2395257", "name": "Formation of dehydro-hydroxylysino-norleucine cross-links", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10540843", "species_10509625" ], "products": [ "species_10543638" ], "modifiers": [], "additional_components": [ "Q9N4U2", "WBGene00000647", "Q9N4U2", "WBGene00000647", "Q9N4U2", "WBGene00000647" ] }, "reaction_10543701": { "compartment": "compartment_984", "id": "reaction_10543701", "reactome": "R-CEL-2243931", "name": "Formation of dehydro-lysinonorleucine cross-links", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10540843", "species_10509625" ], "products": [ "species_10543699" ], "modifiers": [], "additional_components": [ "Q9N4U2", "WBGene00000647", "Q9N4U2", "WBGene00000647", "Q9N4U2", "WBGene00000647" ] }, "reaction_10544086": { "compartment": "compartment_984", "id": "reaction_10544086", "reactome": "R-CEL-2395324", "name": "Formation of hydroxylysyl-pyrrole cross-links", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10543979", "species_10543638" ], "products": [ "species_10544084" ], "modifiers": [], "additional_components": [ "Q9N4U2", "WBGene00000647", "Q9N4U2", "WBGene00000647", "Q9N4U2", "WBGene00000647" ] }, "reaction_10544024": { "compartment": "compartment_984", "id": "reaction_10544024", "reactome": "R-CEL-2395302", "name": "Formation of hydroxylysino-5-ketonorleucine cross-links", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509625", "species_10544022" ], "products": [ "species_10543979" ], "modifiers": [], "additional_components": [ "Q9N4U2", "WBGene00000647", "Q9N4U2", "WBGene00000647", "Q9N4U2", "WBGene00000647" ] }, "reaction_10544026": { "compartment": "compartment_984", "id": "reaction_10544026", "reactome": "R-CEL-2395314", "name": "Formation of lysino-5-ketonorleucine cross-links", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509625", "species_10544022" ], "products": [ "species_10543730" ], "modifiers": [], "additional_components": [ "Q9N4U2", "WBGene00000647", "Q9N4U2", "WBGene00000647", "Q9N4U2", "WBGene00000647" ] }, "reaction_10543754": { "compartment": "compartment_984", "id": "reaction_10543754", "reactome": "R-CEL-2250301", "name": "Formation of lysyl-pyrrole cross-links", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10543638", "species_10543730" ], "products": [ "species_10543752" ], "modifiers": [], "additional_components": [ "Q9N4U2", "WBGene00000647", "Q9N4U2", "WBGene00000647", "Q9N4U2", "WBGene00000647" ] }, "reaction_10543642": { "compartment": "compartment_984", "id": "reaction_10543642", "reactome": "R-CEL-2243926", "name": "Formation of histidino-hydroxylysinonorleucine cross-links", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509625", "species_10543638" ], "products": [ "species_10543640" ], "modifiers": [], "additional_components": [ "Q9N4U2", "WBGene00000647", "Q9N4U2", "WBGene00000647", "Q9N4U2", "WBGene00000647" ] }, "reaction_10544063": { "compartment": "compartment_984", "id": "reaction_10544063", "reactome": "R-CEL-2395322", "name": "Formation of lysyl-pyridinoline cross-links", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10543979", "species_10543730" ], "products": [ "species_10544061" ], "modifiers": [], "additional_components": [ "Q9N4U2", "WBGene00000647", "Q9N4U2", "WBGene00000647", "Q9N4U2", "WBGene00000647" ] }, "reaction_10543532": { "compartment": "compartment_984", "id": "reaction_10543532", "reactome": "R-CEL-2213208", "name": "Type X collagen associates with collagen type II fibrils", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10517286", "species_10543524" ], "products": [ "species_10543530" ], "modifiers": [], "additional_components": [ "O76368", "WBGene00000674", "Q09457", "WBGene00000251", "Q9N4U2", "WBGene00000647", "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689", "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689", "O76368", "WBGene00000674", "Q09457", "WBGene00000251", "Q9N4U2", "WBGene00000647" ] }, "reaction_10534606": { "compartment": "compartment_984", "id": "reaction_10534606", "reactome": "R-CEL-1474266", "name": "Formation of collagen fibrils", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10534596" ], "products": [ "species_10534604" ], "modifiers": [], "additional_components": [ "P17140", "WBGene00002280", "O76368", "WBGene00000674", "Q09457", "WBGene00000251", "Q9N4U2", "WBGene00000647", "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689", "Q21437", "WBGene00000659", "Q9N4U2", "WBGene00000647", "O76368", "WBGene00000674", "Q09457", "WBGene00000251", "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689", "P17140", "WBGene00002280", "Q21437", "WBGene00000659" ] }, "reaction_10556034": { "compartment": "compartment_5460", "id": "reaction_10556034", "reactome": "R-CEL-5688276", "name": "SIRT4 transfers ADPRib to GLUD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10503183", "species_113526" ], "products": [ "species_10556024", "species_5688274" ], "modifiers": [ [ "species_10556031", "catalyst" ] ], "additional_components": [ "WBGene00014095", "WBGene00014095", "Q20480", "WBGene00004801", "species_216785" ] }, "reaction_10573249": { "compartment": "compartment_70101", "id": "reaction_10573249", "reactome": "R-CEL-9698844", "name": "MLKL binds HSP90:CDC37", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10550681", "species_10538179", "species_10538177" ], "products": [ "species_10573247" ], "modifiers": [], "additional_components": [ "WBGene00003030", "Q18688", "WBGene00000915", "O02108", "WBGene00021097", "O02108", "WBGene00021097", "Q18688", "WBGene00000915", "Q07292", "WBGene00003030" ] }, "reaction_10505687": { "compartment": "compartment_70101", "id": "reaction_10505687", "reactome": "R-CEL-72621", "name": "Ribosomal scanning ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10505676", "species_113592" ], "products": [ "species_29372", "species_10505676", "species_29370" ], "modifiers": [ [ "species_72617", "catalyst" ], [ "species_113592", "catalyst" ] ], "additional_components": [ "A0A486WX07", "WBGene00002066", "Q20935", "WBGene00018997", "P27639", "WBGene00002083", "O61955", "WBGene00002061", "species_29438", "Q9BKU3", "WBGene00021351", "Q21230", "WBGene00010560", "Q95XR0", "WBGene00021466", "P51403", "WBGene00004471", "Q9NEN6", "WBGene00004475", "Q8WQA8", "WBGene00004489", "Q23312", "WBGene00004476", "O01869", "WBGene00004479", "P49197", "WBGene00004490", "P48156", "WBGene00004477", "Q20206", "WBGene00004480", "Q19877", "WBGene00004492", "Q20228", "WBGene00004478", "P49196", "WBGene00004481", "Q1XFY9", "WBGene00004493", "P46769", "WBGene00004469", "P51404", "WBGene00004482", "P52821", "WBGene00004494", "Q9TXP0", "WBGene00004496", "P48150", "WBGene00004483", "O45499", "WBGene00004495", "Q9N3X2", "WBGene00004473", "Q9XVP0", "WBGene00004484", "Q95Y04", "WBGene00004497", "Q22054", "WBGene00004485", "P90983", "WBGene00004498", "O01692", "WBGene00004486", "P48152", "WBGene00004472", "O18240", "WBGene00004487", "O18650", "WBGene00004488", "P48154", "WBGene00004470", "O17218", "WBGene00004491", "P49041", "WBGene00004474", "Q95QW0", "WBGene00015920", "O01974", "WBGene00001231", "Q94261", "WBGene00019543", "P34339", "WBGene00001209", "Q9XWP7", "WBGene00012738", "P30642", "WBGene00001227", "Q965S8", "WBGene00001232", "O02328", "WBGene00001226", "Q19706", "WBGene00001230", "O61820", "WBGene00001228", "Q18967", "WBGene00001229", "Q9XUP3", "WBGene00001233", "Q9XWI6", "WBGene00001225", "Q9TXU7", "WBGene00019162", "H2L0A8", "WBGene00019157", "A0A486WX07", "WBGene00002066", "Q20935", "WBGene00018997", "P27639", "WBGene00002083", "O61955", "WBGene00002061", "species_29438", "Q9BKU3", "WBGene00021351", "Q21230", "WBGene00010560", "Q95XR0", "WBGene00021466", "P51403", "WBGene00004471", "Q9NEN6", "WBGene00004475", "Q8WQA8", "WBGene00004489", "Q23312", "WBGene00004476", "O01869", "WBGene00004479", "P49197", "WBGene00004490", "P48156", "WBGene00004477", "Q20206", "WBGene00004480", "Q19877", "WBGene00004492", "Q20228", "WBGene00004478", "P49196", "WBGene00004481", "Q1XFY9", "WBGene00004493", "P46769", "WBGene00004469", "P51404", "WBGene00004482", "P52821", "WBGene00004494", "Q9TXP0", "WBGene00004496", "P48150", "WBGene00004483", "O45499", "WBGene00004495", "Q9N3X2", "WBGene00004473", "Q9XVP0", "WBGene00004484", "Q95Y04", "WBGene00004497", "Q22054", "WBGene00004485", "P90983", "WBGene00004498", "O01692", "WBGene00004486", "P48152", "WBGene00004472", "O18240", "WBGene00004487", "O18650", "WBGene00004488", "P48154", "WBGene00004470", "O17218", "WBGene00004491", "P49041", "WBGene00004474", "Q95QW0", "WBGene00015920", "O01974", "WBGene00001231", "Q94261", "WBGene00019543", "P34339", "WBGene00001209", "Q9XWP7", "WBGene00012738", "P30642", "WBGene00001227", "Q965S8", "WBGene00001232", "O02328", "WBGene00001226", "Q19706", "WBGene00001230", "O61820", "WBGene00001228", "Q18967", "WBGene00001229", "Q9XUP3", "WBGene00001233", "Q9XWI6", "WBGene00001225", "Q9TXU7", "WBGene00019162", "H2L0A8", "WBGene00019157" ] }, "reaction_10505999": { "compartment": "compartment_70101", "id": "reaction_10505999", "reactome": "R-CEL-72697", "name": "Start codon recognition", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10505631", "species_10505614", "species_10505676", "species_72617", "species_10505681" ], "products": [ "species_10505631", "species_10505614", "species_10505676", "species_72617", "species_10505681" ], "modifiers": [ [ "species_72617", "catalyst" ] ], "additional_components": [ "Q9BKU3", "WBGene00021351", "Q21230", "WBGene00010560", "Q95XR0", "WBGene00021466", "WBGene00019162", "A0A486WX07", "WBGene00002066", "Q20935", "WBGene00018997", "P27639", "WBGene00002083", "O61955", "WBGene00002061", "species_29438", "Q9BKU3", "WBGene00021351", "Q21230", "WBGene00010560", "Q95XR0", "WBGene00021466", "P51403", "WBGene00004471", "Q9NEN6", "WBGene00004475", "Q8WQA8", "WBGene00004489", "Q23312", "WBGene00004476", "O01869", "WBGene00004479", "P49197", "WBGene00004490", "P48156", "WBGene00004477", "Q20206", "WBGene00004480", "Q19877", "WBGene00004492", "Q20228", "WBGene00004478", "P49196", "WBGene00004481", "Q1XFY9", "WBGene00004493", "P46769", "WBGene00004469", "P51404", "WBGene00004482", "P52821", "WBGene00004494", "Q9TXP0", "WBGene00004496", "P48150", "WBGene00004483", "O45499", "WBGene00004495", "Q9N3X2", "WBGene00004473", "Q9XVP0", "WBGene00004484", "Q95Y04", "WBGene00004497", "Q22054", "WBGene00004485", "P90983", "WBGene00004498", "O01692", "WBGene00004486", "P48152", "WBGene00004472", "O18240", "WBGene00004487", "O18650", "WBGene00004488", "P48154", "WBGene00004470", "O17218", "WBGene00004491", "P49041", "WBGene00004474", "Q95QW0", "WBGene00015920", "O01974", "WBGene00001231", "Q94261", "WBGene00019543", "P34339", "WBGene00001209", "Q9XWP7", "WBGene00012738", "P30642", "WBGene00001227", "Q965S8", "WBGene00001232", "O02328", "WBGene00001226", "Q19706", "WBGene00001230", "O61820", "WBGene00001228", "Q18967", "WBGene00001229", "Q9XUP3", "WBGene00001233", "Q9XWI6", "WBGene00001225", "Q9TXU7", "WBGene00019162", "H2L0A8", "WBGene00019157", "WBGene00016496", "Q9BKU3", "WBGene00021351", "Q21230", "WBGene00010560", "Q95XR0", "WBGene00021466", "WBGene00019162", "A0A486WX07", "WBGene00002066", "Q20935", "WBGene00018997", "P27639", "WBGene00002083", "O61955", "WBGene00002061", "species_29438", "Q9BKU3", "WBGene00021351", "Q21230", "WBGene00010560", "Q95XR0", "WBGene00021466", "P51403", "WBGene00004471", "Q9NEN6", "WBGene00004475", "Q8WQA8", "WBGene00004489", "Q23312", "WBGene00004476", "O01869", "WBGene00004479", "P49197", "WBGene00004490", "P48156", "WBGene00004477", "Q20206", "WBGene00004480", "Q19877", "WBGene00004492", "Q20228", "WBGene00004478", "P49196", "WBGene00004481", "Q1XFY9", "WBGene00004493", "P46769", "WBGene00004469", "P51404", "WBGene00004482", "P52821", "WBGene00004494", "Q9TXP0", "WBGene00004496", "P48150", "WBGene00004483", "O45499", "WBGene00004495", "Q9N3X2", "WBGene00004473", "Q9XVP0", "WBGene00004484", "Q95Y04", "WBGene00004497", "Q22054", "WBGene00004485", "P90983", "WBGene00004498", "O01692", "WBGene00004486", "P48152", "WBGene00004472", "O18240", "WBGene00004487", "O18650", "WBGene00004488", "P48154", "WBGene00004470", "O17218", "WBGene00004491", "P49041", "WBGene00004474", "Q95QW0", "WBGene00015920", "O01974", "WBGene00001231", "Q94261", "WBGene00019543", "P34339", "WBGene00001209", "Q9XWP7", "WBGene00012738", "P30642", "WBGene00001227", "Q965S8", "WBGene00001232", "O02328", "WBGene00001226", "Q19706", "WBGene00001230", "O61820", "WBGene00001228", "Q18967", "WBGene00001229", "Q9XUP3", "WBGene00001233", "Q9XWI6", "WBGene00001225", "Q9TXU7", "WBGene00019162", "H2L0A8", "WBGene00019157", "WBGene00016496" ] }, "reaction_10567089": { "compartment": "compartment_70101", "id": "reaction_10567089", "reactome": "R-CEL-8870469", "name": "RGGT geranylgeranylates RAB proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1131164", "species_10566884" ], "products": [ "species_10567086", "species_10567084", "species_1132084" ], "modifiers": [ [ "species_10566884", "catalyst" ] ], "additional_components": [ "A0A2C9C2Y0", "WBGene00006833", "G5EBF0", "WBGene00011083", "Q94986", "WBGene00004267", "O01803", "WBGene00004274", "P91857", "WBGene00004268", "G5EFC1", "WBGene00004272", "Q21137", "WBGene00019317", "Q9UAQ6", "WBGene00004266", "species_29420", "Q9TYY0", "WBGene00019778", "P41992", "WBGene00015099", "Q9BKQ5", "WBGene00022051", "species_1131164", "Q9TYY0", "WBGene00019778", "P41992", "WBGene00015099", "species_1131164", "Q9BKQ5", "WBGene00022051", "G5EFC1", "WBGene00004272", "Q21137", "WBGene00019317", "A0A2C9C2Y0", "WBGene00006833", "O01803", "WBGene00004274", "Q94986", "WBGene00004267", "P91857", "WBGene00004268", "Q9UAQ6", "WBGene00004266", "G5EBF0", "WBGene00011083", "species_29420", "A0A2C9C2Y0", "WBGene00006833", "G5EBF0", "WBGene00011083", "Q94986", "WBGene00004267", "O01803", "WBGene00004274", "P91857", "WBGene00004268", "G5EFC1", "WBGene00004272", "Q21137", "WBGene00019317", "Q9UAQ6", "WBGene00004266", "species_29420", "Q9TYY0", "WBGene00019778", "P41992", "WBGene00015099", "Q9BKQ5", "WBGene00022051", "species_1131164" ] }, "reaction_10566886": { "compartment": "compartment_70101", "id": "reaction_10566886", "reactome": "R-CEL-8870466", "name": "RGGT:CHM binds RABs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10566765", "species_10566882" ], "products": [ "species_10566884" ], "modifiers": [], "additional_components": [ "Q9TYY0", "WBGene00019778", "P41992", "WBGene00015099", "Q9BKQ5", "WBGene00022051", "species_1131164", "A0A2C9C2Y0", "WBGene00006833", "G5EBF0", "WBGene00011083", "Q94986", "WBGene00004267", "O01803", "WBGene00004274", "P91857", "WBGene00004268", "G5EFC1", "WBGene00004272", "Q21137", "WBGene00019317", "Q9UAQ6", "WBGene00004266", "species_29420", "A0A2C9C2Y0", "WBGene00006833", "G5EBF0", "WBGene00011083", "Q94986", "WBGene00004267", "O01803", "WBGene00004274", "P91857", "WBGene00004268", "G5EFC1", "WBGene00004272", "Q21137", "WBGene00019317", "Q9UAQ6", "WBGene00004266", "species_29420", "Q9TYY0", "WBGene00019778", "P41992", "WBGene00015099", "Q9BKQ5", "WBGene00022051", "species_1131164" ] }, "reaction_10566761": { "compartment": "compartment_70101", "id": "reaction_10566761", "reactome": "R-CEL-8870461", "name": "RABGGTA and RABGGTB bind", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10566757", "species_10566755" ], "products": [ "species_10566759" ], "modifiers": [], "additional_components": [ "WBGene00015099", "WBGene00019778", "Q9TYY0", "WBGene00019778", "P41992", "WBGene00015099" ] }, "reaction_10566767": { "compartment": "compartment_70101", "id": "reaction_10566767", "reactome": "R-CEL-8870465", "name": "RGGT binds the RAB-binding subunit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1131164", "species_10562902", "species_10566759" ], "products": [ "species_10566765" ], "modifiers": [], "additional_components": [ "WBGene00022051", "Q9TYY0", "WBGene00019778", "P41992", "WBGene00015099", "Q9TYY0", "WBGene00019778", "P41992", "WBGene00015099", "Q9BKQ5", "WBGene00022051", "species_1131164" ] }, "reaction_10565410": { "compartment": "compartment_70101", "id": "reaction_10565410", "reactome": "R-CEL-8853379", "name": "ENGASE hydrolyses unfolded protein:(GlcNAc)2 (Man(9-5)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10531865" ], "products": [ "species_8853371", "species_8853381" ], "modifiers": [ [ "species_10565407", "catalyst" ] ], "additional_components": [ "CHEBI:60627", "CHEBI:60628", "species_915149", "CHEBI:60629", "species_964740", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "species_8853396", "CHEBI:91284", "CHEBI:91283", "CHEBI:91282", "CHEBI:91281", "WBGene00017164" ] }, "reaction_10565052": { "compartment": "compartment_70101", "id": "reaction_10565052", "reactome": "R-CEL-8850594", "name": "Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10531865" ], "products": [ "species_1022114", "species_8852852" ], "modifiers": [ [ "species_10565049", "catalyst" ] ], "additional_components": [ "CHEBI:60627", "CHEBI:60628", "species_915149", "CHEBI:60629", "species_964740", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "CHEBI:60628", "CHEBI:60629", "species_964740", "species_915149", "CHEBI:60627", "Q9TW67", "WBGene00010160", "Q9TXH9", "WBGene00017733", "Q23451", "WBGene00013924", "P90859", "WBGene00009164", "Q93561", "WBGene00000843", "P54812", "WBGene00008053", "O16368", "WBGene00004502" ] }, "reaction_10531867": { "compartment": "compartment_70101", "id": "reaction_10531867", "reactome": "R-CEL-1022127", "name": "Ub-unfolded protein:(GlcNAc)2 (Man)9-5 translocates from ERQC to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10531863" ], "products": [ "species_10531865" ], "modifiers": [], "additional_components": [ "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "CHEBI:60627", "CHEBI:60628", "species_915149", "CHEBI:60629", "species_964740", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727" ] }, "reaction_10528423": { "compartment": "compartment_17957", "id": "reaction_10528423", "reactome": "R-CEL-901047", "name": "Binding of ERp57", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10527333", "species_10528419" ], "products": [ "species_10528421" ], "modifiers": [], "additional_components": [ "WBGene00003964", "CHEBI:59080", "P34652", "WBGene00000567", "P27798", "WBGene00000802", "CHEBI:59080", "P34652", "WBGene00000567", "P27798", "WBGene00000802", "G5ED07", "WBGene00003964" ] }, "reaction_10529604": { "compartment": "compartment_20699", "id": "reaction_10529604", "reactome": "R-CEL-964768", "name": "Addition of GlcNAc to the glycan on the A arm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_914003", "species_964740" ], "products": [ "species_964837", "species_205687" ], "modifiers": [ [ "species_10529601", "catalyst" ] ], "additional_components": [ "WBGene00001638" ] }, "reaction_10530596": { "compartment": "compartment_20699", "id": "reaction_10530596", "reactome": "R-CEL-975916", "name": "Addition of GlcNAc to position 5 by MGAT5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_914003", "species_975910" ], "products": [ "species_981617" ], "modifiers": [ [ "species_10530593", "catalyst" ] ], "additional_components": [ "WBGene00001627" ] }, "reaction_10525152": { "compartment": "compartment_12045", "id": "reaction_10525152", "reactome": "R-CEL-446207", "name": "ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_162756", "species_449222" ], "products": [ "species_449293", "species_110096" ], "modifiers": [ [ "species_10525149", "catalyst" ] ], "additional_components": [ "P92012", "WBGene00011193", "U4PE03", "WBGene00019725" ] }, "reaction_10525186": { "compartment": "compartment_12045", "id": "reaction_10525186", "reactome": "R-CEL-446218", "name": "Addition of the first mannose to the N-glycan precursor by ALG1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_162860", "species_449293" ], "products": [ "species_29420", "species_449283" ], "modifiers": [ [ "species_10525183", "catalyst" ] ], "additional_components": [ "WBGene00020820" ] }, "reaction_10525074": { "compartment": "compartment_17957", "id": "reaction_10525074", "reactome": "R-CEL-446188", "name": "ALG3 transfers Man to N-glycan precursor (GlcNAc)2 (Man)5 (PP-Dol)1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449229", "species_449298" ], "products": [ "species_449311", "species_449315" ], "modifiers": [ [ "species_10525066", "catalyst" ], [ "species_10525072", "catalyst" ] ], "additional_components": [ "WBGene00010720", "WBGene00018181" ] }, "reaction_10525091": { "compartment": "compartment_12045", "id": "reaction_10525091", "reactome": "R-CEL-446191", "name": "Addition of N-acetyl-D-glucosamine to Dolichyl phosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_162756", "species_449299" ], "products": [ "species_109402", "species_449222" ], "modifiers": [ [ "species_10525088", "catalyst" ] ], "additional_components": [ "WBGene00013362" ] }, "reaction_10525107": { "compartment": "compartment_17957", "id": "reaction_10525107", "reactome": "R-CEL-446198", "name": "ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449229", "species_449312" ], "products": [ "species_449311", "species_449365" ], "modifiers": [ [ "species_10525104", "catalyst" ], [ "species_10525072", "catalyst" ] ], "additional_components": [ "WBGene00022629", "WBGene00018181" ] }, "reaction_10525127": { "compartment": "compartment_17957", "id": "reaction_10525127", "reactome": "R-CEL-446202", "name": "Addition of the first glucose to the N-glycan precursor by ALG6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449371", "species_532542" ], "products": [ "species_449311", "species_449649" ], "modifiers": [ [ "species_10525124", "catalyst" ] ], "additional_components": [ "WBGene00007435" ] }, "reaction_10525160": { "compartment": "compartment_12045", "id": "reaction_10525160", "reactome": "R-CEL-446208", "name": "Addition of a second mannose to the N-glycan precursor by ALG2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_162860", "species_449283" ], "products": [ "species_449737", "species_29420" ], "modifiers": [ [ "species_10525157", "catalyst" ] ], "additional_components": [ "WBGene00017282" ] }, "reaction_10525176": { "compartment": "compartment_17957", "id": "reaction_10525176", "reactome": "R-CEL-446215", "name": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)6 (PP-Dol)1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449229", "species_449315" ], "products": [ "species_449311", "species_449312" ], "modifiers": [ [ "species_10525173", "catalyst" ], [ "species_10525072", "catalyst" ] ], "additional_components": [ "WBGene00007556", "WBGene00018181" ] }, "reaction_10525178": { "compartment": "compartment_17957", "id": "reaction_10525178", "reactome": "R-CEL-446216", "name": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)8 (PP-Dol)1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449229", "species_449365" ], "products": [ "species_449371", "species_449311" ], "modifiers": [ [ "species_10525173", "catalyst" ], [ "species_10525072", "catalyst" ] ], "additional_components": [ "WBGene00007556", "WBGene00018181" ] }, "reaction_10525083": { "compartment": "compartment_17957", "id": "reaction_10525083", "reactome": "R-CEL-446189", "name": "Addition of a second glucose to the N-glycan precursor by ALG8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449649", "species_532542" ], "products": [ "species_449311", "species_449638" ], "modifiers": [ [ "species_10525080", "catalyst" ] ], "additional_components": [ "WBGene00007464" ] }, "reaction_10565708": { "compartment": "compartment_984", "id": "reaction_10565708", "reactome": "R-CEL-8855711", "name": "PALM-C36-ASGR1:PALM-C54,58-ASGR2 binds desialated glycoproteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8855720", "species_10565704" ], "products": [ "species_10565706" ], "modifiers": [], "additional_components": [ "O18076", "WBGene00011668", "Q9N4W4", "WBGene00021602", "O44871", "WBGene00019914", "Q9N4W5", "WBGene00021603", "P91214", "WBGene00017199", "Q21146", "WBGene00019328", "O18076", "WBGene00011668", "Q9N4W4", "WBGene00021602", "O44871", "WBGene00019914", "Q9N4W5", "WBGene00021603", "P91214", "WBGene00017199", "Q21146", "WBGene00019328", "species_8855720" ] }, "reaction_10510086": { "compartment": "compartment_17957", "id": "reaction_10510086", "reactome": "R-CEL-162683", "name": "glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_75967", "species_8855661" ], "products": [ "species_8855666", "species_76194" ], "modifiers": [ [ "species_10510083", "catalyst" ] ], "additional_components": [ "WBGene00022447" ] }, "reaction_10510118": { "compartment": "compartment_12045", "id": "reaction_10510118", "reactome": "R-CEL-162873", "name": "(ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449229", "species_8855663" ], "products": [ "species_162872", "species_8855667" ], "modifiers": [ [ "species_10510115", "catalyst" ] ], "additional_components": [ "WBGene00020375" ] }, "reaction_10510102": { "compartment": "compartment_12045", "id": "reaction_10510102", "reactome": "R-CEL-162821", "name": "mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449229", "species_8855667" ], "products": [ "species_8855656", "species_162872" ], "modifiers": [ [ "species_10510099", "catalyst" ] ], "additional_components": [ "WBGene00194986" ] }, "reaction_10510110": { "compartment": "compartment_70101", "id": "reaction_10510110", "reactome": "R-CEL-162857", "name": "N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8855657", "species_29356" ], "products": [ "species_8855661", "species_29416" ], "modifiers": [ [ "species_10510107", "catalyst" ] ], "additional_components": [ "WBGene00013131" ] }, "reaction_10510094": { "compartment": "compartment_12045", "id": "reaction_10510094", "reactome": "R-CEL-162798", "name": "mannose(a1-4)glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose(al1-4)glucosaminyl-acyl-PI + diacylglycerol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8855659", "species_1500581" ], "products": [ "species_8855663", "species_1500596" ], "modifiers": [ [ "species_10510091", "catalyst" ] ], "additional_components": [ "WBGene00021840" ] }, "reaction_10569975": { "compartment": "compartment_70101", "id": "reaction_10569975", "reactome": "R-CEL-8955241", "name": "CAND1 binds cytosolic CRL E3 ubiquitin ligases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10556809", "species_10569971" ], "products": [ "species_10569973" ], "modifiers": [], "additional_components": [ "WBGene00013606", "G5ECR7", "WBGene00001235", "Q23457", "WBGene00004320", "Q17390", "WBGene00000837", "Q19213", "WBGene00006922", "P17221", "WBGene00001411", "Q9BKS1", "WBGene00001236", "O61795", "WBGene00020030", "Q20183", "WBGene00006415", "A0PD34", "WBGene00014848", "O62200", "WBGene00014848", "Q03607", "WBGene00014848", "G5ED84", "WBGene00020952", "Q21854", "WBGene00006493", "G5EGS4", "WBGene00002184", "Q17391", "WBGene00000838", "Q94251", "WBGene00001089", "Q17531", "WBGene00007206", "Q17962", "WBGene00007574", "O17324", "WBGene00015673", "Q20367", "WBGene00005013", "Q9GYI0", "WBGene00017920", "O45323", "WBGene00008439", "P34284", "WBGene00015350", "Q6A590", "WBGene00020884", "G5EES6", "WBGene00007333", "Q9N3G1", "WBGene00021815", "Q22071", "WBGene00003177", "G5ECU1", "WBGene00004807", "Q17389", "WBGene00000836", "Q93349", "WBGene00007985", "O45498", "WBGene00009556", "Q965N7", "WBGene00021596", "Q965N6", "WBGene00021597", "G5EFS1", "WBGene00002069", "Q9BL53", "WBGene00022139", "Q9GRV5", "WBGene00006616", "Q23595", "WBGene00014077", "A0A0K3AV89", "Y32G9A.6d", "G5EBJ4", "WBGene00013835", "O18152", "WBGene00012124", "Q9GYM5", "WBGene00019782", "Q23639", "WBGene00000840", "P91404", "WBGene00019993", "G5ECR7", "WBGene00001235", "Q23457", "WBGene00004320", "Q17390", "WBGene00000837", "Q19213", "WBGene00006922", "P17221", "WBGene00001411", "Q9BKS1", "WBGene00001236", "O61795", "WBGene00020030", "Q20183", "WBGene00006415", "A0PD34", "WBGene00014848", "O62200", "WBGene00014848", "Q03607", "WBGene00014848", "G5ED84", "WBGene00020952", "Q21854", "WBGene00006493", "G5EGS4", "WBGene00002184", "Q17391", "WBGene00000838", "Q94251", "WBGene00001089", "Q17531", "WBGene00007206", "Q17962", "WBGene00007574", "O17324", "WBGene00015673", "Q20367", "WBGene00005013", "Q9GYI0", "WBGene00017920", "O45323", "WBGene00008439", "P34284", "WBGene00015350", "Q6A590", "WBGene00020884", "G5EES6", "WBGene00007333", "Q9N3G1", "WBGene00021815", "Q22071", "WBGene00003177", "G5ECU1", "WBGene00004807", "Q17389", "WBGene00000836", "Q93349", "WBGene00007985", "O45498", "WBGene00009556", "Q965N7", "WBGene00021596", "Q965N6", "WBGene00021597", "G5EFS1", "WBGene00002069", "Q9BL53", "WBGene00022139", "Q9GRV5", "WBGene00006616", "Q23595", "WBGene00014077", "A0A0K3AV89", "Y32G9A.6d", "G5EBJ4", "WBGene00013835", "O18152", "WBGene00012124", "Q9GYM5", "WBGene00019782", "Q23639", "WBGene00000840", "P91404", "WBGene00019993", "G5ED41", "WBGene00013606" ] }, "reaction_10569046": { "compartment": "compartment_70101", "id": "reaction_10569046", "reactome": "R-CEL-8951644", "name": "Release of mature NEDD8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10556648" ], "products": [ "species_10556637", "species_10556646" ], "modifiers": [], "additional_components": [ "Q93725", "WBGene00003587", "Q9UAV3", "WBGene00006721", "Q86FN3", "WBGene00006738", "Q9UAV3", "WBGene00006721", "Q86FN3", "WBGene00006738", "WBGene00003587" ] }, "reaction_10570089": { "compartment": "compartment_7660", "id": "reaction_10570089", "reactome": "R-CEL-8956045", "name": "COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10570082" ], "products": [ "species_10570086", "species_10570084" ], "modifiers": [ [ "species_10556775", "catalyst" ] ], "additional_components": [ "Q21554", "WBGene00010890", "Q23457", "WBGene00004320", "Q965F9", "WBGene00003917", "Q18963", "WBGene00008403", "Q93759", "WBGene00009976", "Q22059", "WBGene00011318", "Q4W5Q8", "WBGene00044440", "Q09309", "WBGene00017683", "Q21934", "WBGene00011242", "Q23494", "WBGene00022742", "P90916", "WBGene00003036", "P90917", "WBGene00004312", "P90794", "WBGene00008419", "Q17963", "WBGene00006474", "Q09392", "WBGene00018564", "Q93725", "WBGene00003587", "Q17392", "WBGene00000839", "Q7JP60", "WBGene00019959", "Q7JP60", "WBGene00019959", "Q21554", "WBGene00010890", "Q23457", "WBGene00004320", "Q965F9", "WBGene00003917", "Q18963", "WBGene00008403", "Q93759", "WBGene00009976", "Q22059", "WBGene00011318", "Q4W5Q8", "WBGene00044440", "Q09309", "WBGene00017683", "Q21934", "WBGene00011242", "Q23494", "WBGene00022742", "P90916", "WBGene00003036", "P90917", "WBGene00004312", "P90794", "WBGene00008419", "Q17963", "WBGene00006474", "Q09392", "WBGene00018564", "Q17392", "WBGene00000839", "WBGene00003587", "Q9GS00", "WBGene00000813", "Q9N359", "WBGene00000816", "P91001", "WBGene00000817", "O01422", "WBGene00000814", "Q9N425", "WBGene00000815", "Q95PZ0", "WBGene00000818" ] }, "reaction_10570104": { "compartment": "compartment_70101", "id": "reaction_10570104", "reactome": "R-CEL-8956106", "name": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10532188", "species_10570093" ], "products": [ "species_10532186", "species_10570097" ], "modifiers": [ [ "species_10570093", "catalyst" ], [ "species_10570102", "inhibitor" ] ], "additional_components": [ "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "P35129", "WBGene00002344", "P91853", "WBGene00006732", "Q17720", "WBGene00006717", "Q20617", "WBGene00006719", "G5EGD2", "WBGene00001851", "Q17390", "WBGene00000837", "Q93725", "WBGene00003587", "Q7JP60", "WBGene00019959", "G5ECR7", "WBGene00001235", "Q19213", "WBGene00006922", "Q9BKS1", "WBGene00001236", "Q23457", "WBGene00004320", "P35129", "WBGene00002344", "P91853", "WBGene00006732", "Q17720", "WBGene00006717", "Q20617", "WBGene00006719", "Q17390", "WBGene00000837", "Q93725", "WBGene00003587", "Q7JP60", "WBGene00019959", "G5ECR7", "WBGene00001235", "Q19213", "WBGene00006922", "Q9BKS1", "WBGene00001236", "Q23457", "WBGene00004320", "G5EGD2", "WBGene00001851", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "G5EGD2", "WBGene00001851", "Q17390", "WBGene00000837", "Q93725", "WBGene00003587", "Q7JP60", "WBGene00019959", "G5ECR7", "WBGene00001235", "Q19213", "WBGene00006922", "Q9BKS1", "WBGene00001236", "Q23457", "WBGene00004320", "Q17390", "WBGene00000837", "Q93725", "WBGene00003587", "Q7JP60", "WBGene00019959", "G5ECR7", "WBGene00001235", "Q19213", "WBGene00006922", "Q9BKS1", "WBGene00001236", "Q23457", "WBGene00004320" ] }, "reaction_10569981": { "compartment": "compartment_7660", "id": "reaction_10569981", "reactome": "R-CEL-8955245", "name": "CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10569752", "species_10569977" ], "products": [ "species_10569979" ], "modifiers": [], "additional_components": [ "Q21554", "WBGene00010890", "Q23457", "WBGene00004320", "Q965F9", "WBGene00003917", "Q18963", "WBGene00008403", "Q93759", "WBGene00009976", "Q22059", "WBGene00011318", "Q4W5Q8", "WBGene00044440", "Q09309", "WBGene00017683", "Q21934", "WBGene00011242", "Q23494", "WBGene00022742", "P90916", "WBGene00003036", "P90917", "WBGene00004312", "P90794", "WBGene00008419", "Q17963", "WBGene00006474", "Q09392", "WBGene00018564", "Q17392", "WBGene00000839", "WBGene00013606", "G5ED41", "WBGene00013606", "Q21554", "WBGene00010890", "Q23457", "WBGene00004320", "Q965F9", "WBGene00003917", "Q18963", "WBGene00008403", "Q93759", "WBGene00009976", "Q22059", "WBGene00011318", "Q4W5Q8", "WBGene00044440", "Q09309", "WBGene00017683", "Q21934", "WBGene00011242", "Q23494", "WBGene00022742", "P90916", "WBGene00003036", "P90917", "WBGene00004312", "P90794", "WBGene00008419", "Q17963", "WBGene00006474", "Q09392", "WBGene00018564", "Q17392", "WBGene00000839" ] }, "reaction_10570060": { "compartment": "compartment_70101", "id": "reaction_10570060", "reactome": "R-CEL-8956040", "name": "COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10570047" ], "products": [ "species_10570057", "species_10556646" ], "modifiers": [ [ "species_10566026", "catalyst" ] ], "additional_components": [ "Q7JP60", "WBGene00019959", "O61795", "WBGene00020030", "Q20183", "WBGene00006415", "A0PD34", "WBGene00014848", "O62200", "WBGene00014848", "Q03607", "WBGene00014848", "G5ED84", "WBGene00020952", "Q21854", "WBGene00006493", "G5EGS4", "WBGene00002184", "Q23457", "WBGene00004320", "Q17391", "WBGene00000838", "Q93725", "WBGene00003587", "G5ECR7", "WBGene00001235", "Q17390", "WBGene00000837", "Q9BKS1", "WBGene00001236", "Q19213", "WBGene00006922", "P17221", "WBGene00001411", "Q94251", "WBGene00001089", "Q17531", "WBGene00007206", "Q17962", "WBGene00007574", "O17324", "WBGene00015673", "Q20367", "WBGene00005013", "Q9GYI0", "WBGene00017920", "O45323", "WBGene00008439", "P34284", "WBGene00015350", "Q6A590", "WBGene00020884", "G5EES6", "WBGene00007333", "Q9N3G1", "WBGene00021815", "Q22071", "WBGene00003177", "Q17389", "WBGene00000836", "G5ECU1", "WBGene00004807", "Q9U3C8", "WBGene00010428", "Q93349", "WBGene00007985", "O45498", "WBGene00009556", "Q965N7", "WBGene00021596", "Q965N6", "WBGene00021597", "G5EFS1", "WBGene00002069", "Q9BL53", "WBGene00022139", "Q9GRV5", "WBGene00006616", "Q23595", "WBGene00014077", "A0A0K3AV89", "Y32G9A.6d", "G5EBJ4", "WBGene00013835", "O18152", "WBGene00012124", "Q9GYM5", "WBGene00019782", "Q23639", "WBGene00000840", "P91404", "WBGene00019993", "Q94251", "WBGene00001089", "Q17531", "WBGene00007206", "Q17962", "WBGene00007574", "O17324", "WBGene00015673", "Q20367", "WBGene00005013", "Q9GYI0", "WBGene00017920", "O45323", "WBGene00008439", "P34284", "WBGene00015350", "Q6A590", "WBGene00020884", "G5EES6", "WBGene00007333", "Q9N3G1", "WBGene00021815", "Q22071", "WBGene00003177", "G5ECU1", "WBGene00004807", "Q17389", "WBGene00000836", "Q23457", "WBGene00004320", "Q7JP60", "WBGene00019959", "Q9U3C8", "WBGene00010428", "G5ECR7", "WBGene00001235", "Q17390", "WBGene00000837", "Q19213", "WBGene00006922", "P17221", "WBGene00001411", "Q9BKS1", "WBGene00001236", "O61795", "WBGene00020030", "Q20183", "WBGene00006415", "A0PD34", "WBGene00014848", "O62200", "WBGene00014848", "Q03607", "WBGene00014848", "G5ED84", "WBGene00020952", "Q21854", "WBGene00006493", "G5EGS4", "WBGene00002184", "Q17391", "WBGene00000838", "Q93349", "WBGene00007985", "O45498", "WBGene00009556", "Q965N7", "WBGene00021596", "Q965N6", "WBGene00021597", "G5EFS1", "WBGene00002069", "Q9BL53", "WBGene00022139", "Q9GRV5", "WBGene00006616", "Q23595", "WBGene00014077", "A0A0K3AV89", "Y32G9A.6d", "G5EBJ4", "WBGene00013835", "O18152", "WBGene00012124", "Q9GYM5", "WBGene00019782", "Q23639", "WBGene00000840", "P91404", "WBGene00019993", "WBGene00003587", "Q9N359", "WBGene00000816", "P91001", "WBGene00000817", "Q95PZ0", "WBGene00000818", "Q9GS00", "WBGene00000813", "O01422", "WBGene00000814", "Q9N425", "WBGene00000815" ] }, "reaction_10570095": { "compartment": "compartment_70101", "id": "reaction_10570095", "reactome": "R-CEL-8956103", "name": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds hydroxyprolyl-HIF-alpha", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10570091", "species_10532134" ], "products": [ "species_10570093" ], "modifiers": [], "additional_components": [ "Q17390", "WBGene00000837", "Q93725", "WBGene00003587", "Q7JP60", "WBGene00019959", "G5ECR7", "WBGene00001235", "Q19213", "WBGene00006922", "Q9BKS1", "WBGene00001236", "Q23457", "WBGene00004320", "WBGene00001851", "G5EGD2", "WBGene00001851", "Q17390", "WBGene00000837", "Q93725", "WBGene00003587", "Q7JP60", "WBGene00019959", "G5ECR7", "WBGene00001235", "Q19213", "WBGene00006922", "Q9BKS1", "WBGene00001236", "Q23457", "WBGene00004320" ] }, "reaction_10520016": { "compartment": "compartment_70101", "id": "reaction_10520016", "reactome": "R-CEL-381111", "name": "EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10505631", "species_113592" ], "products": [ "species_10520013", "species_29370" ], "modifiers": [ [ "species_10519989", "catalyst" ] ], "additional_components": [ "Q9BKU3", "WBGene00021351", "Q21230", "WBGene00010560", "Q95XR0", "WBGene00021466", "Q21230", "WBGene00010560", "Q9BKU3", "WBGene00021351", "Q95XR0", "WBGene00021466", "Q19192", "WBGene00003970" ] }, "reaction_10519991": { "compartment": "compartment_12045", "id": "reaction_10519991", "reactome": "R-CEL-381087", "name": "Dimerization of PERK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10519980" ], "products": [ "species_10519989" ], "modifiers": [], "additional_components": [ "WBGene00003970", "Q19192", "WBGene00003970" ] }, "reaction_10520006": { "compartment": "compartment_12045", "id": "reaction_10520006", "reactome": "R-CEL-381091", "name": "IRE1 dimer autophosphorylates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10519998", "species_113592" ], "products": [ "species_29370", "species_10520003" ], "modifiers": [ [ "species_10519998", "catalyst" ] ], "additional_components": [ "Q09499", "WBGene00002147", "Q09499", "WBGene00002147", "Q09499", "WBGene00002147" ] }, "reaction_10520008": { "compartment": "compartment_12045", "id": "reaction_10520008", "reactome": "R-CEL-381109", "name": "IRE1 binds IRE1 forming dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10519996" ], "products": [ "species_10519998" ], "modifiers": [], "additional_components": [ "WBGene00002147", "Q09499", "WBGene00002147" ] }, "reaction_10567201": { "compartment": "compartment_20699", "id": "reaction_10567201", "reactome": "R-CEL-8874208", "name": "CREB3L3 translocates from the endoplasmic reticulum membrane to the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10567199" ], "products": [ "species_10567195" ], "modifiers": [], "additional_components": [ "WBGene00002783", "WBGene00002783" ] }, "reaction_10567187": { "compartment": "compartment_7660", "id": "reaction_10567187", "reactome": "R-CEL-8874202", "name": "CREB3L3 translocates from the cytosol to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10567179" ], "products": [ "species_10567185" ], "modifiers": [], "additional_components": [ "WBGene00002783", "WBGene00002783" ] }, "reaction_10567183": { "compartment": "compartment_20699", "id": "reaction_10567183", "reactome": "R-CEL-8874201", "name": "MBTPS2 (S2P) cleaves CREB3L3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10567177" ], "products": [ "species_10567181", "species_10567179" ], "modifiers": [ [ "species_10522008", "catalyst" ] ], "additional_components": [ "WBGene00002783", "WBGene00002783", "WBGene00002783", "WBGene00013225" ] }, "reaction_10519975": { "compartment": "compartment_70101", "id": "reaction_10519975", "reactome": "R-CEL-381026", "name": "ATF6 (ATF6-alpha) translocates from the cytosol to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10519971" ], "products": [ "species_10519973" ], "modifiers": [], "additional_components": [ "WBGene00000222", "WBGene00000222" ] }, "reaction_10522011": { "compartment": "compartment_20699", "id": "reaction_10522011", "reactome": "R-CEL-420818", "name": "MBTPS2 (S2P) cleaves ATF6 (ATF6-alpha)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10520023" ], "products": [ "species_10522003", "species_10519971" ], "modifiers": [ [ "species_10522008", "catalyst" ] ], "additional_components": [ "WBGene00000222", "WBGene00000222", "WBGene00000222", "WBGene00013225" ] }, "reaction_10520031": { "compartment": "compartment_12045", "id": "reaction_10520031", "reactome": "R-CEL-381186", "name": "ATF6 (ATF6-alpha) translocates from the endoplasmic reticulum to the Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10520027" ], "products": [ "species_10520021" ], "modifiers": [], "additional_components": [ "WBGene00000222", "WBGene00000222" ] }, "reaction_10517698": { "compartment": "compartment_876", "id": "reaction_10517698", "reactome": "R-CEL-265177", "name": "Exocyst complex formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10517679", "species_10517694", "species_10517659", "species_10517674", "species_10517689", "species_10517669", "species_10517684", "species_10517664" ], "products": [ "species_10517696" ], "modifiers": [], "additional_components": [ "WBGene00013687", "WBGene00016606", "WBGene00004753", "WBGene00016188", "WBGene00017284", "WBGene00016376", "WBGene00018703", "WBGene00004752", "Q22706", "WBGene00004752", "Q20678", "WBGene00018703", "Q18406", "WBGene00016376", "Q19262", "WBGene00017284", "Q18286", "WBGene00016188", "Q9XWS2", "WBGene00004753", "P91149", "WBGene00016606", "Q95Q35", "WBGene00013687" ] }, "reaction_10555315": { "compartment": "compartment_70101", "id": "reaction_10555315", "reactome": "R-CEL-5676917", "name": "MRSBs reduce L-methyl-(R)-S-oxide to L-methionine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5676932", "species_10506160" ], "products": [ "species_10506158", "species_174390" ], "modifiers": [ [ "species_10555312", "catalyst" ] ], "additional_components": [ "WBGene00015062", "WBGene00015062", "P34436", "WBGene00018419" ] }, "reaction_10555323": { "compartment": "compartment_70101", "id": "reaction_10555323", "reactome": "R-CEL-5676966", "name": "PCMT1 transfers CH3 from AdoMet to isoAsp to form MetAsp", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5687536", "species_71284" ], "products": [ "species_5687529", "species_71285" ], "modifiers": [ [ "species_10555320", "catalyst" ] ], "additional_components": [ "WBGene00003954" ] }, "reaction_10522946": { "compartment": "compartment_876", "id": "reaction_10522946", "reactome": "R-CEL-427656", "name": "SLC34A1,2 cotransports Pi, 3Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109277", "species_74113" ], "products": [ "species_29372", "species_83910" ], "modifiers": [ [ "species_10522943", "catalyst" ] ], "additional_components": [ "WBGene00022767" ] }, "reaction_10555765": { "compartment": "compartment_3828046", "id": "reaction_10555765", "reactome": "R-CEL-5684864", "name": "NAPSA, CTSH, PGA3-5 cleave pro-SFTPB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10555678", "species_5685882" ], "products": [ "species_10555690", "species_10555684", "species_10555696" ], "modifiers": [ [ "species_10555762", "catalyst" ] ], "additional_components": [ "Q18276", "WBGene00004995", "Q18279", "WBGene00004993", "Q18276", "WBGene00004995", "Q18279", "WBGene00004993", "Q18276", "WBGene00004995", "Q18279", "WBGene00004993", "Q18276", "WBGene00004995", "Q18279", "WBGene00004993", "Q18020", "WBGene00007605", "Q21966", "WBGene00000217", "Q22972", "WBGene00017881", "Q7JKL9", "WBGene00013973", "Q86NE0", "WBGene00000215", "Q8MYN5", "WBGene00012683", "Q8MYN6", "WBGene00012682", "Q8MYN7", "WBGene00012681", "G5EC01", "WBGene00077655", "G5EEI4", "WBGene00000214", "O01530", "WBGene00000219", "O01531", "WBGene00017678", "O01532", "WBGene00000218", "O45072", "WBGene00015700", "P55956", "WBGene00000216" ] }, "reaction_10555575": { "compartment": "compartment_2133233", "id": "reaction_10555575", "reactome": "R-CEL-5683714", "name": "ABCA3 transports PC, PG from ER membrane to lamellar body", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_5684863" ], "products": [ "species_29372", "species_29370", "species_5684869" ], "modifiers": [ [ "species_10555572", "catalyst" ] ], "additional_components": [ "species_194276", "species_1524042", "species_194276", "species_1524042", "WBGene00000022" ] }, "reaction_10558534": { "compartment": "compartment_3828046", "id": "reaction_10558534", "reactome": "R-CEL-6791016", "name": "SFTPB binds itself", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10555684" ], "products": [ "species_10555767" ], "modifiers": [], "additional_components": [ "Q18276", "WBGene00004995", "Q18279", "WBGene00004993", "Q18276", "WBGene00004995", "Q18279", "WBGene00004993" ] }, "reaction_10572265": { "compartment": "compartment_12045", "id": "reaction_10572265", "reactome": "R-CEL-9624789", "name": "pro-SFTPB translocates from ER membrane to multivesicle body", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10572263" ], "products": [ "species_10555678" ], "modifiers": [], "additional_components": [ "Q18276", "WBGene00004995", "Q18279", "WBGene00004993", "Q18276", "WBGene00004995", "Q18279", "WBGene00004993" ] }, "reaction_10509923": { "compartment": "compartment_70101", "id": "reaction_10509923", "reactome": "R-CEL-156930", "name": "GTP-binding activates eEF2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509919", "species_29438" ], "products": [ "species_10509921" ], "modifiers": [], "additional_components": [ "WBGene00001167", "species_29438", "P29691", "WBGene00001167" ] }, "reaction_10505689": { "compartment": "compartment_70101", "id": "reaction_10505689", "reactome": "R-CEL-72631", "name": "Formation of the cap-binding eIF4F complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10505660", "species_10505655", "species_10505665" ], "products": [ "species_10505667" ], "modifiers": [], "additional_components": [ "WBGene00002061", "Q20935", "WBGene00018997", "P27639", "WBGene00002083", "WBGene00002066", "A0A486WX07", "WBGene00002066", "Q20935", "WBGene00018997", "P27639", "WBGene00002083", "O61955", "WBGene00002061" ] }, "reaction_10505697": { "compartment": "compartment_70101", "id": "reaction_10505697", "reactome": "R-CEL-72669", "name": "Met-tRNAi binds to eIF2:GTP to form the ternary complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_72393", "species_10505633" ], "products": [ "species_10505635" ], "modifiers": [ [ "species_29438", "catalyst" ] ], "additional_components": [ "species_29438", "Q9BKU3", "WBGene00021351", "Q21230", "WBGene00010560", "Q95XR0", "WBGene00021466", "species_29438", "Q9BKU3", "WBGene00021351", "Q21230", "WBGene00010560", "Q95XR0", "WBGene00021466" ] }, "reaction_10505997": { "compartment": "compartment_70101", "id": "reaction_10505997", "reactome": "R-CEL-72691", "name": "Formation of the 43S pre-initiation complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10505993", "species_10505635" ], "products": [ "species_10505637" ], "modifiers": [], "additional_components": [ "P51403", "WBGene00004471", "Q9NEN6", "WBGene00004475", "Q8WQA8", "WBGene00004489", "Q23312", "WBGene00004476", "O01869", "WBGene00004479", "P49197", "WBGene00004490", "P48156", "WBGene00004477", "Q20206", "WBGene00004480", "Q19877", "WBGene00004492", "Q20228", "WBGene00004478", "P49196", "WBGene00004481", "Q1XFY9", "WBGene00004493", "P46769", "WBGene00004469", "P51404", "WBGene00004482", "P52821", "WBGene00004494", "Q9TXP0", "WBGene00004496", "P48150", "WBGene00004483", "O45499", "WBGene00004495", "Q9N3X2", "WBGene00004473", "Q9XVP0", "WBGene00004484", "Q95Y04", "WBGene00004497", "Q22054", "WBGene00004485", "P90983", "WBGene00004498", "O01692", "WBGene00004486", "P48152", "WBGene00004472", "O18240", "WBGene00004487", "O18650", "WBGene00004488", "P48154", "WBGene00004470", "O17218", "WBGene00004491", "P49041", "WBGene00004474", "Q95QW0", "WBGene00015920", "O01974", "WBGene00001231", "Q94261", "WBGene00019543", "P34339", "WBGene00001209", "Q9XWP7", "WBGene00012738", "P30642", "WBGene00001227", "Q965S8", "WBGene00001232", "O02328", "WBGene00001226", "Q19706", "WBGene00001230", "O61820", "WBGene00001228", "Q18967", "WBGene00001229", "Q9XUP3", "WBGene00001233", "Q9XWI6", "WBGene00001225", "Q9TXU7", "WBGene00019162", "species_29438", "Q9BKU3", "WBGene00021351", "Q21230", "WBGene00010560", "Q95XR0", "WBGene00021466", "species_29438", "Q9BKU3", "WBGene00021351", "Q21230", "WBGene00010560", "Q95XR0", "WBGene00021466", "P51403", "WBGene00004471", "Q9NEN6", "WBGene00004475", "Q8WQA8", "WBGene00004489", "Q23312", "WBGene00004476", "O01869", "WBGene00004479", "P49197", "WBGene00004490", "P48156", "WBGene00004477", "Q20206", "WBGene00004480", "Q19877", "WBGene00004492", "Q20228", "WBGene00004478", "P49196", "WBGene00004481", "Q1XFY9", "WBGene00004493", "P46769", "WBGene00004469", "P51404", "WBGene00004482", "P52821", "WBGene00004494", "Q9TXP0", "WBGene00004496", "P48150", "WBGene00004483", "O45499", "WBGene00004495", "Q9N3X2", "WBGene00004473", "Q9XVP0", "WBGene00004484", "Q95Y04", "WBGene00004497", "Q22054", "WBGene00004485", "P90983", "WBGene00004498", "O01692", "WBGene00004486", "P48152", "WBGene00004472", "O18240", "WBGene00004487", "O18650", "WBGene00004488", "P48154", "WBGene00004470", "O17218", "WBGene00004491", "P49041", "WBGene00004474", "Q95QW0", "WBGene00015920", "O01974", "WBGene00001231", "Q94261", "WBGene00019543", "P34339", "WBGene00001209", "Q9XWP7", "WBGene00012738", "P30642", "WBGene00001227", "Q965S8", "WBGene00001232", "O02328", "WBGene00001226", "Q19706", "WBGene00001230", "O61820", "WBGene00001228", "Q18967", "WBGene00001229", "Q9XUP3", "WBGene00001233", "Q9XWI6", "WBGene00001225", "Q9TXU7", "WBGene00019162" ] }, "reaction_10505695": { "compartment": "compartment_70101", "id": "reaction_10505695", "reactome": "R-CEL-72663", "name": "De novo formation of eIF2:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10505631", "species_29438" ], "products": [ "species_10505633" ], "modifiers": [], "additional_components": [ "Q9BKU3", "WBGene00021351", "Q21230", "WBGene00010560", "Q95XR0", "WBGene00021466", "species_29438", "Q9BKU3", "WBGene00021351", "Q21230", "WBGene00010560", "Q95XR0", "WBGene00021466" ] }, "reaction_10505987": { "compartment": "compartment_70101", "id": "reaction_10505987", "reactome": "R-CEL-72671", "name": "eIF5B:GTP is hydrolyzed and released", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10505981" ], "products": [ "species_10505983", "species_29372", "species_10505985" ], "modifiers": [], "additional_components": [ "P91914", "WBGene00004441", "Q19869", "WBGene00004440", "O01868", "WBGene00004436", "P48162", "WBGene00004438", "P52819", "WBGene00004434", "P48158", "WBGene00004435", "Q09533", "WBGene00004421", "P34334", "WBGene00004433", "O02639", "WBGene00004431", "Q95Y90", "WBGene00004420", "O44480", "WBGene00004432", "Q22716", "WBGene00004446", "Q9U332", "WBGene00004445", "Q9XWS4", "WBGene00004444", "P52814", "WBGene00004453", "O45226", "WBGene00004443", "Q21930", "WBGene00004442", "P48166", "WBGene00004454", "Q9BKU5", "WBGene00021350", "P50880", "WBGene00004414", "P61866", "WBGene00004424", "O17570", "WBGene00004452", "Q19162", "WBGene00004423", "Q9U2A8", "WBGene00004456", "Q9N4I4", "WBGene00004412", "O62388", "WBGene00012179", "O01504", "WBGene00016493", "P49181", "WBGene00004450", "P91913", "WBGene00004409", "P49180", "WBGene00004447", "Q93572", "WBGene00004408", "P34662", "WBGene00004449", "Q9XVF7", "WBGene00004413", "O45946", "WBGene00004430", "Q966C6", "WBGene00004419", "Q9BL19", "WBGene00004429", "O01802", "WBGene00004418", "P91374", "WBGene00004427", "P47991", "WBGene00004417", "Q9XVE9", "WBGene00004426", "P49405", "WBGene00004416", "Q27389", "WBGene00004428", "P37165", "WBGene00006725", "P91128", "WBGene00004425", "O02056", "WBGene00004415", "P51403", "WBGene00004471", "Q9NEN6", "WBGene00004475", "Q8WQA8", "WBGene00004489", "Q23312", "WBGene00004476", "O01869", "WBGene00004479", "P49197", "WBGene00004490", "P48156", "WBGene00004477", "Q20206", "WBGene00004480", "Q19877", "WBGene00004492", "Q20228", "WBGene00004478", "P49196", "WBGene00004481", "Q1XFY9", "WBGene00004493", "P46769", "WBGene00004469", "P51404", "WBGene00004482", "P52821", "WBGene00004494", "Q9TXP0", "WBGene00004496", "P48150", "WBGene00004483", "O45499", "WBGene00004495", "Q9N3X2", "WBGene00004473", "Q9XVP0", "WBGene00004484", "Q95Y04", "WBGene00004497", "Q22054", "WBGene00004485", "P90983", "WBGene00004498", "O01692", "WBGene00004486", "P48152", "WBGene00004472", "O18240", "WBGene00004487", "O18650", "WBGene00004488", "P48154", "WBGene00004470", "O17218", "WBGene00004491", "P49041", "WBGene00004474", "G5EGT7", "WBGene00021857", "species_29438", "G5EGT7", "WBGene00021857", "species_29420", "P91914", "WBGene00004441", "Q19869", "WBGene00004440", "O01868", "WBGene00004436", "P48162", "WBGene00004438", "P52819", "WBGene00004434", "P48158", "WBGene00004435", "Q09533", "WBGene00004421", "P34334", "WBGene00004433", "O02639", "WBGene00004431", "Q95Y90", "WBGene00004420", "O44480", "WBGene00004432", "Q22716", "WBGene00004446", "Q9U332", "WBGene00004445", "Q9XWS4", "WBGene00004444", "P52814", "WBGene00004453", "O45226", "WBGene00004443", "Q21930", "WBGene00004442", "P48166", "WBGene00004454", "Q9BKU5", "WBGene00021350", "P50880", "WBGene00004414", "P61866", "WBGene00004424", "O17570", "WBGene00004452", "Q19162", "WBGene00004423", "Q9U2A8", "WBGene00004456", "Q9N4I4", "WBGene00004412", "O62388", "WBGene00012179", "O01504", "WBGene00016493", "P49181", "WBGene00004450", "P91913", "WBGene00004409", "P49180", "WBGene00004447", "Q93572", "WBGene00004408", "P34662", "WBGene00004449", "Q9XVF7", "WBGene00004413", "O45946", "WBGene00004430", "Q966C6", "WBGene00004419", "Q9BL19", "WBGene00004429", "O01802", "WBGene00004418", "P91374", "WBGene00004427", "P47991", "WBGene00004417", "Q9XVE9", "WBGene00004426", "P49405", "WBGene00004416", "Q27389", "WBGene00004428", "P37165", "WBGene00006725", "P91128", "WBGene00004425", "O02056", "WBGene00004415", "P51403", "WBGene00004471", "Q9NEN6", "WBGene00004475", "Q8WQA8", "WBGene00004489", "Q23312", "WBGene00004476", "O01869", "WBGene00004479", "P49197", "WBGene00004490", "P48156", "WBGene00004477", "Q20206", "WBGene00004480", "Q19877", "WBGene00004492", "Q20228", "WBGene00004478", "P49196", "WBGene00004481", "Q1XFY9", "WBGene00004493", "P46769", "WBGene00004469", "P51404", "WBGene00004482", "P52821", "WBGene00004494", "Q9TXP0", "WBGene00004496", "P48150", "WBGene00004483", "O45499", "WBGene00004495", "Q9N3X2", "WBGene00004473", "Q9XVP0", "WBGene00004484", "Q95Y04", "WBGene00004497", "Q22054", "WBGene00004485", "P90983", "WBGene00004498", "O01692", "WBGene00004486", "P48152", "WBGene00004472", "O18240", "WBGene00004487", "O18650", "WBGene00004488", "P48154", "WBGene00004470", "O17218", "WBGene00004491", "P49041", "WBGene00004474" ] }, "reaction_10505989": { "compartment": "compartment_70101", "id": "reaction_10505989", "reactome": "R-CEL-72672", "name": "The 60S subunit joins the translation initiation complex ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10505979", "species_10505683", "species_10505970" ], "products": [ "species_10505981" ], "modifiers": [], "additional_components": [ "G5EGT7", "WBGene00021857", "species_29438", "P51403", "WBGene00004471", "Q9NEN6", "WBGene00004475", "Q8WQA8", "WBGene00004489", "Q23312", "WBGene00004476", "O01869", "WBGene00004479", "P49197", "WBGene00004490", "P48156", "WBGene00004477", "Q20206", "WBGene00004480", "Q19877", "WBGene00004492", "Q20228", "WBGene00004478", "P49196", "WBGene00004481", "Q1XFY9", "WBGene00004493", "P46769", "WBGene00004469", "P51404", "WBGene00004482", "P52821", "WBGene00004494", "Q9TXP0", "WBGene00004496", "P48150", "WBGene00004483", "O45499", "WBGene00004495", "Q9N3X2", "WBGene00004473", "Q9XVP0", "WBGene00004484", "Q95Y04", "WBGene00004497", "Q22054", "WBGene00004485", "P90983", "WBGene00004498", "O01692", "WBGene00004486", "P48152", "WBGene00004472", "O18240", "WBGene00004487", "O18650", "WBGene00004488", "P48154", "WBGene00004470", "O17218", "WBGene00004491", "P49041", "WBGene00004474", "P91914", "WBGene00004441", "Q19869", "WBGene00004440", "O01868", "WBGene00004436", "P48162", "WBGene00004438", "P52819", "WBGene00004434", "P48158", "WBGene00004435", "Q09533", "WBGene00004421", "P34334", "WBGene00004433", "O02639", "WBGene00004431", "Q95Y90", "WBGene00004420", "O44480", "WBGene00004432", "Q22716", "WBGene00004446", "Q9U332", "WBGene00004445", "Q9XWS4", "WBGene00004444", "P52814", "WBGene00004453", "O45226", "WBGene00004443", "Q21930", "WBGene00004442", "P48166", "WBGene00004454", "Q9BKU5", "WBGene00021350", "P50880", "WBGene00004414", "P61866", "WBGene00004424", "O17570", "WBGene00004452", "Q19162", "WBGene00004423", "Q9U2A8", "WBGene00004456", "Q9N4I4", "WBGene00004412", "O62388", "WBGene00012179", "O01504", "WBGene00016493", "P49181", "WBGene00004450", "P91913", "WBGene00004409", "P49180", "WBGene00004447", "Q93572", "WBGene00004408", "P34662", "WBGene00004449", "Q9XVF7", "WBGene00004413", "O45946", "WBGene00004430", "Q966C6", "WBGene00004419", "Q9BL19", "WBGene00004429", "O01802", "WBGene00004418", "P91374", "WBGene00004427", "P47991", "WBGene00004417", "Q9XVE9", "WBGene00004426", "P49405", "WBGene00004416", "Q27389", "WBGene00004428", "P37165", "WBGene00006725", "P91128", "WBGene00004425", "O02056", "WBGene00004415", "P91914", "WBGene00004441", "Q19869", "WBGene00004440", "O01868", "WBGene00004436", "P48162", "WBGene00004438", "P52819", "WBGene00004434", "P48158", "WBGene00004435", "Q09533", "WBGene00004421", "P34334", "WBGene00004433", "O02639", "WBGene00004431", "Q95Y90", "WBGene00004420", "O44480", "WBGene00004432", "Q22716", "WBGene00004446", "Q9U332", "WBGene00004445", "Q9XWS4", "WBGene00004444", "P52814", "WBGene00004453", "O45226", "WBGene00004443", "Q21930", "WBGene00004442", "P48166", "WBGene00004454", "Q9BKU5", "WBGene00021350", "P50880", "WBGene00004414", "P61866", "WBGene00004424", "O17570", "WBGene00004452", "Q19162", "WBGene00004423", "Q9U2A8", "WBGene00004456", "Q9N4I4", "WBGene00004412", "O62388", "WBGene00012179", "O01504", "WBGene00016493", "P49181", "WBGene00004450", "P91913", "WBGene00004409", "P49180", "WBGene00004447", "Q93572", "WBGene00004408", "P34662", "WBGene00004449", "Q9XVF7", "WBGene00004413", "O45946", "WBGene00004430", "Q966C6", "WBGene00004419", "Q9BL19", "WBGene00004429", "O01802", "WBGene00004418", "P91374", "WBGene00004427", "P47991", "WBGene00004417", "Q9XVE9", "WBGene00004426", "P49405", "WBGene00004416", "Q27389", "WBGene00004428", "P37165", "WBGene00006725", "P91128", "WBGene00004425", "O02056", "WBGene00004415", "P51403", "WBGene00004471", "Q9NEN6", "WBGene00004475", "Q8WQA8", "WBGene00004489", "Q23312", "WBGene00004476", "O01869", "WBGene00004479", "P49197", "WBGene00004490", "P48156", "WBGene00004477", "Q20206", "WBGene00004480", "Q19877", "WBGene00004492", "Q20228", "WBGene00004478", "P49196", "WBGene00004481", "Q1XFY9", "WBGene00004493", "P46769", "WBGene00004469", "P51404", "WBGene00004482", "P52821", "WBGene00004494", "Q9TXP0", "WBGene00004496", "P48150", "WBGene00004483", "O45499", "WBGene00004495", "Q9N3X2", "WBGene00004473", "Q9XVP0", "WBGene00004484", "Q95Y04", "WBGene00004497", "Q22054", "WBGene00004485", "P90983", "WBGene00004498", "O01692", "WBGene00004486", "P48152", "WBGene00004472", "O18240", "WBGene00004487", "O18650", "WBGene00004488", "P48154", "WBGene00004470", "O17218", "WBGene00004491", "P49041", "WBGene00004474", "G5EGT7", "WBGene00021857", "species_29438" ] }, "reaction_10505991": { "compartment": "compartment_70101", "id": "reaction_10505991", "reactome": "R-CEL-72673", "name": "Release of 40S and 60S subunits from the 80S ribosome ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10505614", "species_10505972" ], "products": [ "species_10505614", "species_10505542", "species_10505970" ], "modifiers": [], "additional_components": [ "WBGene00019162", "P91914", "WBGene00004441", "Q19869", "WBGene00004440", "O01868", "WBGene00004436", "P48162", "WBGene00004438", "P52819", "WBGene00004434", "P48158", "WBGene00004435", "Q09533", "WBGene00004421", "P34334", "WBGene00004433", "O02639", "WBGene00004431", "Q95Y90", "WBGene00004420", "O44480", "WBGene00004432", "Q22716", "WBGene00004446", "Q9U332", "WBGene00004445", "Q9XWS4", "WBGene00004444", "P52814", "WBGene00004453", "O45226", "WBGene00004443", "Q21930", "WBGene00004442", "P48166", "WBGene00004454", "Q9BKU5", "WBGene00021350", "P50880", "WBGene00004414", "P61866", "WBGene00004424", "O17570", "WBGene00004452", "Q19162", "WBGene00004423", "Q9U2A8", "WBGene00004456", "Q9N4I4", "WBGene00004412", "O62388", "WBGene00012179", "O01504", "WBGene00016493", "P49181", "WBGene00004450", "P91913", "WBGene00004409", "P49180", "WBGene00004447", "Q93572", "WBGene00004408", "P34662", "WBGene00004449", "Q9XVF7", "WBGene00004413", "O45946", "WBGene00004430", "Q966C6", "WBGene00004419", "Q9BL19", "WBGene00004429", "O01802", "WBGene00004418", "P91374", "WBGene00004427", "P47991", "WBGene00004417", "Q9XVE9", "WBGene00004426", "P49405", "WBGene00004416", "Q27389", "WBGene00004428", "P37165", "WBGene00006725", "P91128", "WBGene00004425", "O02056", "WBGene00004415", "P51403", "WBGene00004471", "Q9NEN6", "WBGene00004475", "Q8WQA8", "WBGene00004489", "Q23312", "WBGene00004476", "O01869", "WBGene00004479", "P49197", "WBGene00004490", "P48156", "WBGene00004477", "Q20206", "WBGene00004480", "Q19877", "WBGene00004492", "Q20228", "WBGene00004478", "P49196", "WBGene00004481", "Q1XFY9", "WBGene00004493", "P46769", "WBGene00004469", "P51404", "WBGene00004482", "P52821", "WBGene00004494", "Q9TXP0", "WBGene00004496", "P48150", "WBGene00004483", "O45499", "WBGene00004495", "Q9N3X2", "WBGene00004473", "Q9XVP0", "WBGene00004484", "Q95Y04", "WBGene00004497", "Q22054", "WBGene00004485", "P90983", "WBGene00004498", "O01692", "WBGene00004486", "P48152", "WBGene00004472", "O18240", "WBGene00004487", "O18650", "WBGene00004488", "P48154", "WBGene00004470", "O17218", "WBGene00004491", "P49041", "WBGene00004474", "WBGene00019162", "P51403", "WBGene00004471", "Q9NEN6", "WBGene00004475", "Q8WQA8", "WBGene00004489", "Q23312", "WBGene00004476", "O01869", "WBGene00004479", "P49197", "WBGene00004490", "P48156", "WBGene00004477", "Q20206", "WBGene00004480", "Q19877", "WBGene00004492", "Q20228", "WBGene00004478", "P49196", "WBGene00004481", "Q1XFY9", "WBGene00004493", "P46769", "WBGene00004469", "P51404", "WBGene00004482", "P52821", "WBGene00004494", "Q9TXP0", "WBGene00004496", "P48150", "WBGene00004483", "O45499", "WBGene00004495", "Q9N3X2", "WBGene00004473", "Q9XVP0", "WBGene00004484", "Q95Y04", "WBGene00004497", "Q22054", "WBGene00004485", "P90983", "WBGene00004498", "O01692", "WBGene00004486", "P48152", "WBGene00004472", "O18240", "WBGene00004487", "O18650", "WBGene00004488", "P48154", "WBGene00004470", "O17218", "WBGene00004491", "P49041", "WBGene00004474", "P91914", "WBGene00004441", "Q19869", "WBGene00004440", "O01868", "WBGene00004436", "P48162", "WBGene00004438", "P52819", "WBGene00004434", "P48158", "WBGene00004435", "Q09533", "WBGene00004421", "P34334", "WBGene00004433", "O02639", "WBGene00004431", "Q95Y90", "WBGene00004420", "O44480", "WBGene00004432", "Q22716", "WBGene00004446", "Q9U332", "WBGene00004445", "Q9XWS4", "WBGene00004444", "P52814", "WBGene00004453", "O45226", "WBGene00004443", "Q21930", "WBGene00004442", "P48166", "WBGene00004454", "Q9BKU5", "WBGene00021350", "P50880", "WBGene00004414", "P61866", "WBGene00004424", "O17570", "WBGene00004452", "Q19162", "WBGene00004423", "Q9U2A8", "WBGene00004456", "Q9N4I4", "WBGene00004412", "O62388", "WBGene00012179", "O01504", "WBGene00016493", "P49181", "WBGene00004450", "P91913", "WBGene00004409", "P49180", "WBGene00004447", "Q93572", "WBGene00004408", "P34662", "WBGene00004449", "Q9XVF7", "WBGene00004413", "O45946", "WBGene00004430", "Q966C6", "WBGene00004419", "Q9BL19", "WBGene00004429", "O01802", "WBGene00004418", "P91374", "WBGene00004427", "P47991", "WBGene00004417", "Q9XVE9", "WBGene00004426", "P49405", "WBGene00004416", "Q27389", "WBGene00004428", "P37165", "WBGene00006725", "P91128", "WBGene00004425", "O02056", "WBGene00004415" ] }, "reaction_10505995": { "compartment": "compartment_70101", "id": "reaction_10505995", "reactome": "R-CEL-72676", "name": "eIF3 and eIF1A bind to the 40S subunit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10505614", "species_10505609", "species_10505542" ], "products": [ "species_10505993" ], "modifiers": [], "additional_components": [ "WBGene00019162", "Q95QW0", "WBGene00015920", "O01974", "WBGene00001231", "Q94261", "WBGene00019543", "P34339", "WBGene00001209", "Q9XWP7", "WBGene00012738", "P30642", "WBGene00001227", "Q965S8", "WBGene00001232", "O02328", "WBGene00001226", "Q19706", "WBGene00001230", "O61820", "WBGene00001228", "Q18967", "WBGene00001229", "Q9XUP3", "WBGene00001233", "Q9XWI6", "WBGene00001225", "P51403", "WBGene00004471", "Q9NEN6", "WBGene00004475", "Q8WQA8", "WBGene00004489", "Q23312", "WBGene00004476", "O01869", "WBGene00004479", "P49197", "WBGene00004490", "P48156", "WBGene00004477", "Q20206", "WBGene00004480", "Q19877", "WBGene00004492", "Q20228", "WBGene00004478", "P49196", "WBGene00004481", "Q1XFY9", "WBGene00004493", "P46769", "WBGene00004469", "P51404", "WBGene00004482", "P52821", "WBGene00004494", "Q9TXP0", "WBGene00004496", "P48150", "WBGene00004483", "O45499", "WBGene00004495", "Q9N3X2", "WBGene00004473", "Q9XVP0", "WBGene00004484", "Q95Y04", "WBGene00004497", "Q22054", "WBGene00004485", "P90983", "WBGene00004498", "O01692", "WBGene00004486", "P48152", "WBGene00004472", "O18240", "WBGene00004487", "O18650", "WBGene00004488", "P48154", "WBGene00004470", "O17218", "WBGene00004491", "P49041", "WBGene00004474", "P51403", "WBGene00004471", "Q9NEN6", "WBGene00004475", "Q8WQA8", "WBGene00004489", "Q23312", "WBGene00004476", "O01869", "WBGene00004479", "P49197", "WBGene00004490", "P48156", "WBGene00004477", "Q20206", "WBGene00004480", "Q19877", "WBGene00004492", "Q20228", "WBGene00004478", "P49196", "WBGene00004481", "Q1XFY9", "WBGene00004493", "P46769", "WBGene00004469", "P51404", "WBGene00004482", "P52821", "WBGene00004494", "Q9TXP0", "WBGene00004496", "P48150", "WBGene00004483", "O45499", "WBGene00004495", "Q9N3X2", "WBGene00004473", "Q9XVP0", "WBGene00004484", "Q95Y04", "WBGene00004497", "Q22054", "WBGene00004485", "P90983", "WBGene00004498", "O01692", "WBGene00004486", "P48152", "WBGene00004472", "O18240", "WBGene00004487", "O18650", "WBGene00004488", "P48154", "WBGene00004470", "O17218", "WBGene00004491", "P49041", "WBGene00004474", "Q95QW0", "WBGene00015920", "O01974", "WBGene00001231", "Q94261", "WBGene00019543", "P34339", "WBGene00001209", "Q9XWP7", "WBGene00012738", "P30642", "WBGene00001227", "Q965S8", "WBGene00001232", "O02328", "WBGene00001226", "Q19706", "WBGene00001230", "O61820", "WBGene00001228", "Q18967", "WBGene00001229", "Q9XUP3", "WBGene00001233", "Q9XWI6", "WBGene00001225", "Q9TXU7", "WBGene00019162" ] }, "reaction_10537497": { "compartment": "compartment_70101", "id": "reaction_10537497", "reactome": "R-CEL-1799332", "name": "Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10537493", "species_10537491" ], "products": [ "species_10537495" ], "modifiers": [], "additional_components": [ "P91914", "WBGene00004441", "Q19869", "WBGene00004440", "O01868", "WBGene00004436", "P48162", "WBGene00004438", "P52819", "WBGene00004434", "P48158", "WBGene00004435", "Q09533", "WBGene00004421", "P34334", "WBGene00004433", "O02639", "WBGene00004431", "Q95Y90", "WBGene00004420", "O44480", "WBGene00004432", "Q22716", "WBGene00004446", "Q9U332", "WBGene00004445", "Q9XWS4", "WBGene00004444", "P52814", "WBGene00004453", "O45226", "WBGene00004443", "Q21930", "WBGene00004442", "P48166", "WBGene00004454", "Q9BKU5", "WBGene00021350", "P50880", "WBGene00004414", "P61866", "WBGene00004424", "O17570", "WBGene00004452", "Q19162", "WBGene00004423", "Q9U2A8", "WBGene00004456", "Q9N4I4", "WBGene00004412", "O62388", "WBGene00012179", "O01504", "WBGene00016493", "P49181", "WBGene00004450", "P91913", "WBGene00004409", "P49180", "WBGene00004447", "Q93572", "WBGene00004408", "P34662", "WBGene00004449", "Q9XVF7", "WBGene00004413", "O45946", "WBGene00004430", "Q966C6", "WBGene00004419", "Q9BL19", "WBGene00004429", "O01802", "WBGene00004418", "P91374", "WBGene00004427", "P47991", "WBGene00004417", "Q9XVE9", "WBGene00004426", "P49405", "WBGene00004416", "Q27389", "WBGene00004428", "P37165", "WBGene00006725", "P91128", "WBGene00004425", "O02056", "WBGene00004415", "P51403", "WBGene00004471", "Q9NEN6", "WBGene00004475", "Q8WQA8", "WBGene00004489", "Q23312", "WBGene00004476", "O01869", "WBGene00004479", "P49197", "WBGene00004490", "P48156", "WBGene00004477", "Q20206", "WBGene00004480", "Q19877", "WBGene00004492", "Q20228", "WBGene00004478", "P49196", "WBGene00004481", "Q1XFY9", "WBGene00004493", "P46769", "WBGene00004469", "P51404", "WBGene00004482", "P52821", "WBGene00004494", "Q9TXP0", "WBGene00004496", "P48150", "WBGene00004483", "O45499", "WBGene00004495", "Q9N3X2", "WBGene00004473", "Q9XVP0", "WBGene00004484", "Q95Y04", "WBGene00004497", "Q22054", "WBGene00004485", "P90983", "WBGene00004498", "O01692", "WBGene00004486", "P48152", "WBGene00004472", "O18240", "WBGene00004487", "O18650", "WBGene00004488", "P48154", "WBGene00004470", "O17218", "WBGene00004491", "P49041", "WBGene00004474", "G5EE80", "WBGene00009012", "P91240", "WBGene00017245", "O16927", "WBGene00017799", "P34642", "WBGene00013984", "O61749", "WBGene00018159", "Q20822", "WBGene00010097", "G5EE80", "WBGene00009012", "P91240", "WBGene00017245", "O16927", "WBGene00017799", "P34642", "WBGene00013984", "O61749", "WBGene00018159", "Q20822", "WBGene00010097", "P91914", "WBGene00004441", "Q19869", "WBGene00004440", "O01868", "WBGene00004436", "P48162", "WBGene00004438", "P52819", "WBGene00004434", "P48158", "WBGene00004435", "Q09533", "WBGene00004421", "P34334", "WBGene00004433", "O02639", "WBGene00004431", "Q95Y90", "WBGene00004420", "O44480", "WBGene00004432", "Q22716", "WBGene00004446", "Q9U332", "WBGene00004445", "Q9XWS4", "WBGene00004444", "P52814", "WBGene00004453", "O45226", "WBGene00004443", "Q21930", "WBGene00004442", "P48166", "WBGene00004454", "Q9BKU5", "WBGene00021350", "P50880", "WBGene00004414", "P61866", "WBGene00004424", "O17570", "WBGene00004452", "Q19162", "WBGene00004423", "Q9U2A8", "WBGene00004456", "Q9N4I4", "WBGene00004412", "O62388", "WBGene00012179", "O01504", "WBGene00016493", "P49181", "WBGene00004450", "P91913", "WBGene00004409", "P49180", "WBGene00004447", "Q93572", "WBGene00004408", "P34662", "WBGene00004449", "Q9XVF7", "WBGene00004413", "O45946", "WBGene00004430", "Q966C6", "WBGene00004419", "Q9BL19", "WBGene00004429", "O01802", "WBGene00004418", "P91374", "WBGene00004427", "P47991", "WBGene00004417", "Q9XVE9", "WBGene00004426", "P49405", "WBGene00004416", "Q27389", "WBGene00004428", "P37165", "WBGene00006725", "P91128", "WBGene00004425", "O02056", "WBGene00004415", "P51403", "WBGene00004471", "Q9NEN6", "WBGene00004475", "Q8WQA8", "WBGene00004489", "Q23312", "WBGene00004476", "O01869", "WBGene00004479", "P49197", "WBGene00004490", "P48156", "WBGene00004477", "Q20206", "WBGene00004480", "Q19877", "WBGene00004492", "Q20228", "WBGene00004478", "P49196", "WBGene00004481", "Q1XFY9", "WBGene00004493", "P46769", "WBGene00004469", "P51404", "WBGene00004482", "P52821", "WBGene00004494", "Q9TXP0", "WBGene00004496", "P48150", "WBGene00004483", "O45499", "WBGene00004495", "Q9N3X2", "WBGene00004473", "Q9XVP0", "WBGene00004484", "Q95Y04", "WBGene00004497", "Q22054", "WBGene00004485", "P90983", "WBGene00004498", "O01692", "WBGene00004486", "P48152", "WBGene00004472", "O18240", "WBGene00004487", "O18650", "WBGene00004488", "P48154", "WBGene00004470", "O17218", "WBGene00004491", "P49041", "WBGene00004474" ] }, "reaction_10556841": { "compartment": "compartment_70101", "id": "reaction_10556841", "reactome": "R-CEL-5691512", "name": "APEH hydrolyses NAc-Ser-protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5691496", "species_29356" ], "products": [ "species_6785226", "species_5691517" ], "modifiers": [ [ "species_10556838", "catalyst" ] ], "additional_components": [ "species_5691517", "species_6785219", "WBGene00001058" ] }, "reaction_10562140": { "compartment": "compartment_70101", "id": "reaction_10562140", "reactome": "R-CEL-6800138", "name": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to ETF1 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10562118", "species_71284" ], "products": [ "species_10562125", "species_71285" ], "modifiers": [ [ "species_10562137", "catalyst" ] ], "additional_components": [ "O45622", "WBGene00010405", "species_29438", "O16520", "WBGene00020269", "O45622", "WBGene00010405", "species_29438", "O16520", "WBGene00020269", "O16582", "WBGene00016341", "O45241", "WBGene00007312" ] }, "reaction_10535108": { "compartment": "compartment_12045", "id": "reaction_10535108", "reactome": "R-CEL-1483186", "name": "PC is converted to PS by PTDSS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426925", "species_200736" ], "products": [ "species_264618", "species_1500646" ], "modifiers": [ [ "species_10535105", "catalyst" ] ], "additional_components": [ "WBGene00013920" ] }, "reaction_10534897": { "compartment": "compartment_12045", "id": "reaction_10534897", "reactome": "R-CEL-1482816", "name": "PC is hydrolyzed to 1-acyl LPC by PLA2[6]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_426925" ], "products": [ "species_1524028", "species_1524021" ], "modifiers": [ [ "species_10534894", "catalyst" ] ], "additional_components": [ "Q3V5J7", "WBGene00044468", "O16654", "WBGene00044468", "Q17790", "WBGene00044468", "species_74016", "Q8MXR3", "WBGene00022233" ] }, "reaction_10534753": { "compartment": "compartment_12045", "id": "reaction_10534753", "reactome": "R-CEL-1482547", "name": "1-acyl LPC is acylated to PC by LPCAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524028", "species_1500578" ], "products": [ "species_426925", "species_76194" ], "modifiers": [ [ "species_10534731", "catalyst" ] ], "additional_components": [ "O01925", "WBGene00020115", "G5EC53", "WBGene00016934" ] }, "reaction_10567209": { "compartment": "compartment_12045", "id": "reaction_10567209", "reactome": "R-CEL-8874435", "name": "THEM86B hydrolyses PMCHO, PMETAM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_8874447" ], "products": [ "species_8874450", "species_5696116" ], "modifiers": [ [ "species_10567206", "catalyst" ] ], "additional_components": [ "CHEBI:17810", "CHEBI:17476", "CHEBI:36313", "CHEBI:36314", "WBGene00010943" ] }, "reaction_10534907": { "compartment": "compartment_12045", "id": "reaction_10534907", "reactome": "R-CEL-1482856", "name": "PC is hydrolyzed to 1-acyl LPC by PLA2[5]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_426925" ], "products": [ "species_1524028", "species_1524021" ], "modifiers": [ [ "species_10534904", "catalyst" ] ], "additional_components": [ "WBGene00016661" ] }, "reaction_10535867": { "compartment": "compartment_984", "id": "reaction_10535867", "reactome": "R-CEL-1602399", "name": "PC is hydrolyzed to 1-acyl LPC by PLB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_429802" ], "products": [ "species_1602390", "species_1602366" ], "modifiers": [ [ "species_10530529", "catalyst" ] ], "additional_components": [ "Q8MXQ8", "WBGene00022256", "Q9N2Z4", "WBGene00022256" ] }, "reaction_10535869": { "compartment": "compartment_984", "id": "reaction_10535869", "reactome": "R-CEL-1602417", "name": "PC is hydrolyzed to 1-acyl LPC by PLA2[16]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_429802" ], "products": [ "species_1602390", "species_1602366" ], "modifiers": [ [ "species_10535837", "catalyst" ], [ "species_10535855", "inhibitor" ] ], "additional_components": [ "species_74016", "Q17790", "WBGene00044468", "O16654", "WBGene00044468", "Q3V5J7", "WBGene00044468", "Q18339", "WBGene00016288", "G4RY15", "WBGene00015631", "P34472", "WBGene00010228", "Q22591", "WBGene00020585" ] }, "reaction_10534734": { "compartment": "compartment_12045", "id": "reaction_10534734", "reactome": "R-CEL-1482533", "name": "2-acyl LPC is acylated to PC by LPCAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500578", "species_975614" ], "products": [ "species_426925", "species_76194" ], "modifiers": [ [ "species_10534731", "catalyst" ] ], "additional_components": [ "O01925", "WBGene00020115", "G5EC53", "WBGene00016934" ] }, "reaction_10534914": { "compartment": "compartment_12045", "id": "reaction_10534914", "reactome": "R-CEL-1482868", "name": "PI is hydrolyzed to 1-acyl LPI by PLA2[12]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_426639" ], "products": [ "species_1498733", "species_1524021" ], "modifiers": [ [ "species_10534852", "catalyst" ] ], "additional_components": [ "Q3V5J7", "WBGene00044468", "O16654", "WBGene00044468", "Q17790", "WBGene00044468", "species_74016" ] }, "reaction_10534789": { "compartment": "compartment_12045", "id": "reaction_10534789", "reactome": "R-CEL-1482626", "name": "2-acyl LPI is acylated to PI by MBOAT7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1498737", "species_1500578" ], "products": [ "species_426639", "species_76194" ], "modifiers": [ [ "species_10534763", "catalyst" ] ], "additional_components": [ "WBGene00008806" ] }, "reaction_10535862": { "compartment": "compartment_984", "id": "reaction_10535862", "reactome": "R-CEL-1602377", "name": "PI is hydrolyzed to 1-acyl LPI by PLA2[15]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_426658" ], "products": [ "species_1602420", "species_1602366" ], "modifiers": [ [ "species_10535837", "catalyst" ], [ "species_10535855", "inhibitor" ] ], "additional_components": [ "species_74016", "Q17790", "WBGene00044468", "O16654", "WBGene00044468", "Q3V5J7", "WBGene00044468", "Q18339", "WBGene00016288", "G4RY15", "WBGene00015631", "P34472", "WBGene00010228", "Q22591", "WBGene00020585" ] }, "reaction_10534766": { "compartment": "compartment_12045", "id": "reaction_10534766", "reactome": "R-CEL-1482598", "name": "1-acyl LPI is acylated to PI by MBOAT7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1498733", "species_1500578" ], "products": [ "species_426639", "species_76194" ], "modifiers": [ [ "species_10534763", "catalyst" ] ], "additional_components": [ "WBGene00008806" ] }, "reaction_10557548": { "compartment": "compartment_17906", "id": "reaction_10557548", "reactome": "R-CEL-5696074", "name": "AGK:Mg2+ phosphorylates MAG, DAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5696066", "species_5696069" ], "products": [ "species_5696026", "species_5696037" ], "modifiers": [ [ "species_10557545", "catalyst" ] ], "additional_components": [ "species_6814795", "species_114519", "species_1524101", "species_417891", "Q10123", "WBGene00018674", "species_114632" ] }, "reaction_10534916": { "compartment": "compartment_12045", "id": "reaction_10534916", "reactome": "R-CEL-1482884", "name": "PE is hydrolyzed to 1-acyl LPE by PLA2[2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1500581" ], "products": [ "species_1498738", "species_1524021" ], "modifiers": [ [ "species_10534904", "catalyst" ] ], "additional_components": [ "WBGene00016661" ] }, "reaction_10534918": { "compartment": "compartment_12045", "id": "reaction_10534918", "reactome": "R-CEL-1482887", "name": "PE is hydrolyzed to 1-acyl LPE by PLA2[3]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1500581" ], "products": [ "species_1498738", "species_1524021" ], "modifiers": [ [ "species_10534894", "catalyst" ] ], "additional_components": [ "Q3V5J7", "WBGene00044468", "O16654", "WBGene00044468", "Q17790", "WBGene00044468", "species_74016", "Q8MXR3", "WBGene00022233" ] }, "reaction_10535864": { "compartment": "compartment_984", "id": "reaction_10535864", "reactome": "R-CEL-1602398", "name": "PE is hydrolyzed to 1-acyl LPE by PLA2[16]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1602375", "species_109276" ], "products": [ "species_1602372", "species_1602366" ], "modifiers": [ [ "species_10535837", "catalyst" ], [ "species_10535855", "inhibitor" ] ], "additional_components": [ "species_74016", "Q17790", "WBGene00044468", "O16654", "WBGene00044468", "Q3V5J7", "WBGene00044468", "Q18339", "WBGene00016288", "G4RY15", "WBGene00015631", "P34472", "WBGene00010228", "Q22591", "WBGene00020585" ] }, "reaction_10557512": { "compartment": "compartment_70101", "id": "reaction_10557512", "reactome": "R-CEL-5694583", "name": "ABHD4 hydrolyses NAPE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5694568", "species_29356" ], "products": [ "species_5694580", "species_5694567" ], "modifiers": [ [ "species_10557509", "catalyst" ] ], "additional_components": [ "WBGene00007711" ] }, "reaction_10534842": { "compartment": "compartment_12045", "id": "reaction_10534842", "reactome": "R-CEL-1482667", "name": "1-acyl LPE is acylated to PE by LPEAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500578", "species_1498738" ], "products": [ "species_76194", "species_1500581" ], "modifiers": [ [ "species_10534808", "catalyst" ] ], "additional_components": [ "G5EC53", "WBGene00016934", "H9G2W5", "WBGene00007446", "O01925", "WBGene00020115" ] }, "reaction_10534811": { "compartment": "compartment_12045", "id": "reaction_10534811", "reactome": "R-CEL-1482646", "name": "2-acyl LPE is acylated to PE by LPEAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1498729", "species_1500578" ], "products": [ "species_76194", "species_1500581" ], "modifiers": [ [ "species_10534808", "catalyst" ] ], "additional_components": [ "G5EC53", "WBGene00016934", "H9G2W5", "WBGene00007446", "O01925", "WBGene00020115" ] }, "reaction_10534786": { "compartment": "compartment_17906", "id": "reaction_10534786", "reactome": "R-CEL-1482604", "name": "PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1500590" ], "products": [ "species_1500580", "species_1524103" ], "modifiers": [ [ "species_10534783", "catalyst" ] ], "additional_components": [ "O16654", "WBGene00044468", "Q17790", "WBGene00044468", "Q3V5J7", "WBGene00044468" ] }, "reaction_10534981": { "compartment": "compartment_70101", "id": "reaction_10534981", "reactome": "R-CEL-1483002", "name": "DHAP is converted to 1-acyl GO3P by GNPAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500578", "species_75970" ], "products": [ "species_75973", "species_76194" ], "modifiers": [ [ "species_10534978", "catalyst" ] ], "additional_components": [ "WBGene00012911" ] }, "reaction_10512710": { "compartment": "compartment_5460", "id": "reaction_10512710", "reactome": "R-CEL-188467", "name": "Gly-3-P+FAD->DHAP+FADH2 (catalyzed by mitochondrial Gly-Phos dehydrogenase)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113596", "species_188458" ], "products": [ "species_31649", "species_188451" ], "modifiers": [ [ "species_10512707", "catalyst" ] ], "additional_components": [ "WBGene00012031" ] }, "reaction_10534758": { "compartment": "compartment_17906", "id": "reaction_10534758", "reactome": "R-CEL-1482548", "name": "1-acyl LPA is acylated to PA by AGPAT5 (OM)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500578", "species_1500580" ], "products": [ "species_1500590", "species_76194" ], "modifiers": [ [ "species_10534755", "catalyst" ] ], "additional_components": [ "WBGene00017888" ] }, "reaction_10534839": { "compartment": "compartment_70101", "id": "reaction_10534839", "reactome": "R-CEL-1482656", "name": "PA is hydrolysed to 1-acyl LPA by PLA2[1]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_426755" ], "products": [ "species_1500604", "species_1524021" ], "modifiers": [ [ "species_10534783", "catalyst" ] ], "additional_components": [ "O16654", "WBGene00044468", "Q17790", "WBGene00044468", "Q3V5J7", "WBGene00044468" ] }, "reaction_10534855": { "compartment": "compartment_12045", "id": "reaction_10534855", "reactome": "R-CEL-1482679", "name": "PA is hydrolysed to 1-acyl LPA by PLA2G2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_426755" ], "products": [ "species_1500604", "species_1524021" ], "modifiers": [ [ "species_10534852", "catalyst" ] ], "additional_components": [ "Q3V5J7", "WBGene00044468", "O16654", "WBGene00044468", "Q17790", "WBGene00044468", "species_74016" ] }, "reaction_10507577": { "compartment": "compartment_70101", "id": "reaction_10507577", "reactome": "R-CEL-75889", "name": "DHAP is converted to G3P by GPD1/GPD1L", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_75970", "species_73473" ], "products": [ "species_76114", "species_29360" ], "modifiers": [ [ "species_10507574", "catalyst" ] ], "additional_components": [ "Q9XTS4", "WBGene00009824", "P34517", "WBGene00010778" ] }, "reaction_10527340": { "compartment": "compartment_12045", "id": "reaction_10527340", "reactome": "R-CEL-549112", "name": "G3P is acylated to 1-acyl LPA by AGPAT6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500578", "species_76114" ], "products": [ "species_1500604", "species_76194" ], "modifiers": [ [ "species_10507520", "catalyst" ] ], "additional_components": [ "G5EE59", "WBGene00010902", "Q21812", "WBGene00011106", "Q9N5S8", "WBGene00018657" ] }, "reaction_10507532": { "compartment": "compartment_12045", "id": "reaction_10507532", "reactome": "R-CEL-75885", "name": "1-acyl LPA is acylated to PA by AGPAT (LPAAT)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500604", "species_1500578" ], "products": [ "species_426755", "species_76194" ], "modifiers": [ [ "species_10507529", "catalyst" ] ], "additional_components": [ "G5EE59", "WBGene00010902", "Q21812", "WBGene00011106", "Q9N5S8", "WBGene00018657", "O16526", "WBGene00020264", "Q22267", "WBGene00011543", "Q93841", "WBGene00010339", "Q95R12", "WBGene00017888" ] }, "reaction_10535100": { "compartment": "compartment_12045", "id": "reaction_10535100", "reactome": "R-CEL-1483182", "name": "PC is hydrolyzed to PA and choline by PLD1/2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_426925" ], "products": [ "species_264618", "species_426755" ], "modifiers": [ [ "species_10535095", "catalyst" ] ], "additional_components": [ "WBGene00004040" ] }, "reaction_10534863": { "compartment": "compartment_17906", "id": "reaction_10534863", "reactome": "R-CEL-1482695", "name": "G3P is acylated to 1-acyl LPA by GPAM/GPAT2 (OM)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500578", "species_76114" ], "products": [ "species_76194", "species_1500580" ], "modifiers": [ [ "species_10507537", "catalyst" ] ], "additional_components": [ "WBGene00017261" ] }, "reaction_10535871": { "compartment": "compartment_984", "id": "reaction_10535871", "reactome": "R-CEL-1602446", "name": "PA is hydrolyzed to 1-acyl LPA by PLA2[15]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_1602448" ], "products": [ "species_1602447", "species_1602366" ], "modifiers": [ [ "species_10535837", "catalyst" ], [ "species_10535855", "inhibitor" ] ], "additional_components": [ "species_74016", "Q17790", "WBGene00044468", "O16654", "WBGene00044468", "Q3V5J7", "WBGene00044468", "Q18339", "WBGene00016288", "G4RY15", "WBGene00015631", "P34472", "WBGene00010228", "Q22591", "WBGene00020585" ] }, "reaction_10569180": { "compartment": "compartment_984", "id": "reaction_10569180", "reactome": "R-CEL-8952251", "name": "PLA2G15 hydrolyses LPC to GPCho and LCFA(-)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_2173763" ], "products": [ "species_8954142", "species_8952253" ], "modifiers": [ [ "species_10569177", "catalyst" ] ], "additional_components": [ "WBGene00010872" ] }, "reaction_10534976": { "compartment": "compartment_12045", "id": "reaction_10534976", "reactome": "R-CEL-1482976", "name": "CDP-DAG is converted to PI by CDIPT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426955", "species_426910" ], "products": [ "species_426639", "species_109395" ], "modifiers": [ [ "species_10534973", "catalyst" ] ], "additional_components": [ "species_114632", "species_266099", "Q9U2G1", "WBGene00012897" ] }, "reaction_10535085": { "compartment": "compartment_12045", "id": "reaction_10535085", "reactome": "R-CEL-1483121", "name": "PA is converted to CDP-DAG by CDS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_110614", "species_426755" ], "products": [ "species_111294", "species_426955" ], "modifiers": [ [ "species_10535082", "catalyst" ] ], "additional_components": [ "species_114632", "P53439", "WBGene00016384" ] }, "reaction_10566702": { "compartment": "compartment_70101", "id": "reaction_10566702", "reactome": "R-CEL-8869241", "name": "PITPNM1,2,3 exchange PI for PA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426639", "species_1602448" ], "products": [ "species_426755", "species_426658" ], "modifiers": [ [ "species_10566697", "catalyst" ] ], "additional_components": [ "WBGene00010813" ] }, "reaction_10535034": { "compartment": "compartment_70616", "id": "reaction_10535034", "reactome": "R-CEL-1483063", "name": "PG and CDP-DAG are converted to CL by CRLS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524042", "species_1524064" ], "products": [ "species_1524072", "species_1524067" ], "modifiers": [ [ "species_10534747", "catalyst" ] ], "additional_components": [ "WBGene00017763" ] }, "reaction_10535057": { "compartment": "compartment_12045", "id": "reaction_10535057", "reactome": "R-CEL-1483081", "name": "PCho and CTP are condensed to CDP-Cho by PCYT1 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_110614", "species_1524071" ], "products": [ "species_111294", "species_1524060" ], "modifiers": [ [ "species_10535054", "catalyst" ] ], "additional_components": [ "Q8IU09", "WBGene00021215", "P49583", "WBGene00017241" ] }, "reaction_10534947": { "compartment": "compartment_12045", "id": "reaction_10534947", "reactome": "R-CEL-1482961", "name": "CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524060", "species_1500596" ], "products": [ "species_426925", "species_109395" ], "modifiers": [ [ "species_10534944", "catalyst" ] ], "additional_components": [ "species_114632", "species_266099", "G5EC09", "WBGene00009057", "G5EC25", "WBGene00013024" ] }, "reaction_10534966": { "compartment": "compartment_20699", "id": "reaction_10534966", "reactome": "R-CEL-1482973", "name": "CDP-Cho and DAG are converted to PC by CHPT1 at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524057", "species_1524060" ], "products": [ "species_429785", "species_109395" ], "modifiers": [ [ "species_10534963", "catalyst" ] ], "additional_components": [ "species_114632", "species_266099", "G5EC25", "WBGene00013024" ] }, "reaction_10535031": { "compartment": "compartment_70101", "id": "reaction_10535031", "reactome": "R-CEL-1483004", "name": "Cho is phosphorylated to PCho by CHK dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_264618", "species_113592" ], "products": [ "species_29370", "species_1524071" ], "modifiers": [ [ "species_10535028", "catalyst" ] ], "additional_components": [ "P46560", "WBGene00000513", "O17610", "WBGene00000509", "Q22820", "WBGene00000515", "P46558", "WBGene00000511", "Q22942", "WBGene00000510", "P46559", "WBGene00000512", "Q9GZF3", "WBGene00000514" ] }, "reaction_10557483": { "compartment": "compartment_876", "id": "reaction_10557483", "reactome": "R-CEL-5694485", "name": "ABHD3 hydrolyses LPC(14:0) to 1AGPC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_5694502" ], "products": [ "species_5694457", "species_1861754" ], "modifiers": [ [ "species_10557480", "catalyst" ] ], "additional_components": [ "Q18610", "WBGene00016644", "Q9U1Z6", "WBGene00013358" ] }, "reaction_10567146": { "compartment": "compartment_70101", "id": "reaction_10567146", "reactome": "R-CEL-8873929", "name": "Casein kinase II phosphorylates STARD10", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10567141" ], "products": [ "species_29370", "species_10567144" ], "modifiers": [ [ "species_10515097", "catalyst" ] ], "additional_components": [ "WBGene00012127", "WBGene00012127", "P18334", "WBGene00002191", "P28548", "WBGene00002196" ] }, "reaction_10518395": { "compartment": "compartment_984", "id": "reaction_10518395", "reactome": "R-CEL-372519", "name": "AcCho is hydrolyzed to Cho and acetate by ACHE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_372533" ], "products": [ "species_1524044", "species_264638" ], "modifiers": [ [ "species_10518390", "catalyst" ], [ "species_10518393", "inhibitor" ] ], "additional_components": [ "Q23268", "WBGene00013873", "Q04457", "WBGene00001578", "H9G2Y9", "WBGene00013874", "A0A1C3NSL8", "WBGene00017478", "Q4LDP0", "WBGene00020891", "Q21266", "WBGene00019477", "O01302", "WBGene00011362", "G5EDJ7", "WBGene00013875", "Q9XW75", "WBGene00013540", "Q22008", "WBGene00020125", "P92016", "WBGene00011364", "H2L0K7", "WBGene00020330", "Q23268", "WBGene00013873", "Q04457", "WBGene00001578", "H9G2Y9", "WBGene00013874", "A0A1C3NSL8", "WBGene00017478", "Q4LDP0", "WBGene00020891", "Q21266", "WBGene00019477", "O01302", "WBGene00011362", "G5EDJ7", "WBGene00013875", "Q9XW75", "WBGene00013540", "Q22008", "WBGene00020125", "P92016", "WBGene00011364", "H2L0K7", "WBGene00020330" ] }, "reaction_10567581": { "compartment": "compartment_12045", "id": "reaction_10567581", "reactome": "R-CEL-8877153", "name": "STARD7 binds PC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426925", "species_10567577" ], "products": [ "species_10567579" ], "modifiers": [], "additional_components": [ "WBGene00007386", "Q17764", "WBGene00007386", "species_194276" ] }, "reaction_10535075": { "compartment": "compartment_20699", "id": "reaction_10535075", "reactome": "R-CEL-1483087", "name": "PI is exchanged with PC by PITPNB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_429785", "species_10535071" ], "products": [ "species_1524146", "species_10535073" ], "modifiers": [], "additional_components": [ "species_426639", "Q95XP0", "WBGene00022155", "Q965T2", "WBGene00022155", "Q95XP0", "WBGene00022155", "Q965T2", "WBGene00022155", "species_194276" ] }, "reaction_10535139": { "compartment": "compartment_20699", "id": "reaction_10535139", "reactome": "R-CEL-1483211", "name": "PC:PITPNB is transported from the Golgi membrane to the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10535073" ], "products": [ "species_10535137" ], "modifiers": [], "additional_components": [ "Q95XP0", "WBGene00022155", "Q965T2", "WBGene00022155", "species_194276", "species_194276", "Q95XP0", "WBGene00022155", "Q965T2", "WBGene00022155" ] }, "reaction_10535148": { "compartment": "compartment_12045", "id": "reaction_10535148", "reactome": "R-CEL-1483229", "name": "PI:PITPNB is transported from the ER membrane to the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10535141" ], "products": [ "species_10535071" ], "modifiers": [], "additional_components": [ "species_426639", "Q95XP0", "WBGene00022155", "Q965T2", "WBGene00022155", "species_426639", "Q95XP0", "WBGene00022155", "Q965T2", "WBGene00022155" ] }, "reaction_10507366": { "compartment": "compartment_7660", "id": "reaction_10507366", "reactome": "R-CEL-75172", "name": "Formation of RAD50:MRE11 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10507357", "species_10507362" ], "products": [ "species_10507364" ], "modifiers": [], "additional_components": [ "WBGene00004296", "WBGene00003405", "Q23255", "WBGene00003405", "O44199", "WBGene00004296" ] }, "reaction_10571888": { "compartment": "compartment_70101", "id": "reaction_10571888", "reactome": "R-CEL-9603804", "name": "PEX19 binds class I peroxisomal membrane proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10571868", "species_10520426" ], "products": [ "species_10571870" ], "modifiers": [], "additional_components": [ "A0A486WWU7", "WBGene00000110", "O44555", "WBGene00000111", "Q93930", "WBGene00004199", "P54815", "WBGene00010557", "Q7YWV6", "WBGene00011826", "O45730", "WBGene00004061", "Q6AHP8", "WBGene00001425", "P91262", "WBGene00017574", "Q19189", "WBGene00004197", "Q18598", "WBGene00004059", "A0A1D3PCN1", "WBGene00270319", "Q9XTZ5", "WBGene00007680", "Q19951", "WBGene00004198", "WBGene00004201", "P34453", "WBGene00004201", "A0A486WWU7", "WBGene00000110", "O44555", "WBGene00000111", "Q93930", "WBGene00004199", "P54815", "WBGene00010557", "Q7YWV6", "WBGene00011826", "O45730", "WBGene00004061", "Q6AHP8", "WBGene00001425", "P91262", "WBGene00017574", "Q19189", "WBGene00004197", "Q18598", "WBGene00004059", "A0A1D3PCN1", "WBGene00270319", "Q9XTZ5", "WBGene00007680", "Q19951", "WBGene00004198" ] }, "reaction_10571884": { "compartment": "compartment_17947", "id": "reaction_10571884", "reactome": "R-CEL-9603775", "name": "PEX3:PEX19:class I PMP dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10571872" ], "products": [ "species_10571882", "species_10520426", "species_10520404" ], "modifiers": [], "additional_components": [ "Q18028", "WBGene00004193", "P34453", "WBGene00004201", "A0A486WWU7", "WBGene00000110", "O44555", "WBGene00000111", "Q93930", "WBGene00004199", "P54815", "WBGene00010557", "Q7YWV6", "WBGene00011826", "O45730", "WBGene00004061", "Q6AHP8", "WBGene00001425", "P91262", "WBGene00017574", "Q19189", "WBGene00004197", "Q18598", "WBGene00004059", "A0A1D3PCN1", "WBGene00270319", "Q9XTZ5", "WBGene00007680", "Q19951", "WBGene00004198", "A0A1D3PCN1", "WBGene00270319", "Q9XTZ5", "WBGene00007680", "Q19951", "WBGene00004198", "P54815", "WBGene00010557", "O44555", "WBGene00000111", "A0A486WWU7", "WBGene00000110", "Q93930", "WBGene00004199", "Q6AHP8", "WBGene00001425", "Q18598", "WBGene00004059", "Q19189", "WBGene00004197", "Q7YWV6", "WBGene00011826", "P91262", "WBGene00017574", "O45730", "WBGene00004061", "WBGene00004201", "WBGene00004193" ] }, "reaction_10571886": { "compartment": "compartment_17947", "id": "reaction_10571886", "reactome": "R-CEL-9603784", "name": "PEX19:class I PMP binds PEX3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10571870", "species_10520404" ], "products": [ "species_10571872" ], "modifiers": [], "additional_components": [ "P34453", "WBGene00004201", "A0A486WWU7", "WBGene00000110", "O44555", "WBGene00000111", "Q93930", "WBGene00004199", "P54815", "WBGene00010557", "Q7YWV6", "WBGene00011826", "O45730", "WBGene00004061", "Q6AHP8", "WBGene00001425", "P91262", "WBGene00017574", "Q19189", "WBGene00004197", "Q18598", "WBGene00004059", "A0A1D3PCN1", "WBGene00270319", "Q9XTZ5", "WBGene00007680", "Q19951", "WBGene00004198", "WBGene00004193", "Q18028", "WBGene00004193", "P34453", "WBGene00004201", "A0A486WWU7", "WBGene00000110", "O44555", "WBGene00000111", "Q93930", "WBGene00004199", "P54815", "WBGene00010557", "Q7YWV6", "WBGene00011826", "O45730", "WBGene00004061", "Q6AHP8", "WBGene00001425", "P91262", "WBGene00017574", "Q19189", "WBGene00004197", "Q18598", "WBGene00004059", "A0A1D3PCN1", "WBGene00270319", "Q9XTZ5", "WBGene00007680", "Q19951", "WBGene00004198" ] }, "reaction_10551384": { "compartment": "compartment_70101", "id": "reaction_10551384", "reactome": "R-CEL-5334794", "name": "FABPs bind LCFAs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8876730", "species_10551380" ], "products": [ "species_10551382" ], "modifiers": [], "additional_components": [ "O02324", "WBGene00002260", "O01812", "WBGene00002258", "O01814", "WBGene00002257", "O02323", "WBGene00002259", "Q965W1", "WBGene00021486", "O02324", "WBGene00002260", "O01812", "WBGene00002258", "O01814", "WBGene00002257", "O02323", "WBGene00002259", "Q965W1", "WBGene00021486", "species_8876730" ] }, "reaction_10564685": { "compartment": "compartment_70101", "id": "reaction_10564685", "reactome": "R-CEL-8848339", "name": "PNPLA5 hydrolyzes TAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_549167" ], "products": [ "species_8876730", "species_76103" ], "modifiers": [ [ "species_10564682", "catalyst" ] ], "additional_components": [ "Q11186", "WBGene00015484", "Q18948", "WBGene00015241", "Q9N5Z7", "WBGene00015241" ] }, "reaction_10571751": { "compartment": "compartment_17947", "id": "reaction_10571751", "reactome": "R-CEL-9033485", "name": "PEX2:PEX10:PEX12 monoubiquitinates PEX5L at cysteine-11", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10571746" ], "products": [ "species_10532186", "species_10571748" ], "modifiers": [ [ "species_10571746", "catalyst" ] ], "additional_components": [ "Q19951", "WBGene00004198", "Q93930", "WBGene00004199", "Q18355", "WBGene00016318", "Q19189", "WBGene00004197", "Q18426", "WBGene00004194", "P35129", "WBGene00002344", "P91853", "WBGene00006732", "Q17720", "WBGene00006717", "Q20617", "WBGene00006719", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "P35129", "WBGene00002344", "P91853", "WBGene00006732", "Q17720", "WBGene00006717", "Q20617", "WBGene00006719", "Q19951", "WBGene00004198", "Q93930", "WBGene00004199", "Q18355", "WBGene00016318", "Q19189", "WBGene00004197", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "Q18426", "WBGene00004194", "Q19951", "WBGene00004198", "Q93930", "WBGene00004199", "Q18355", "WBGene00016318", "Q19189", "WBGene00004197", "Q18426", "WBGene00004194", "P35129", "WBGene00002344", "P91853", "WBGene00006732", "Q17720", "WBGene00006717", "Q20617", "WBGene00006719", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727" ] }, "reaction_10571738": { "compartment": "compartment_17947", "id": "reaction_10571738", "reactome": "R-CEL-9033235", "name": "Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10571710" ], "products": [ "species_10569900", "species_10571736" ], "modifiers": [], "additional_components": [ "Q18122", "WBGene00016034", "O16249", "WBGene00018426", "Q17499", "WBGene00007175", "A0A486WVT5", "WBGene00011850", "Q9BIA9", "WBGene00015887", "Q9XW87", "WBGene00013541", "P91148", "WBGene00003584", "G5EGA6", "WBGene00010063", "B3WFZ3", "WBGene00020989", "O01862", "WBGene00020989", "O45003", "WBGene00020989", "Q9GYN3", "WBGene00020989", "Q8MYL7", "WBGene00013220", "O01739", "WBGene00017648", "O45307", "WBGene00008127", "Q19564", "WBGene00017565", "Q95XG9", "WBGene00022076", "B1GRK5", "WBGene00018286", "O62138", "WBGene00008566", "Q18916", "WBGene00017012", "Q19878", "WBGene00009218", "G5EFP8", "WBGene00012911", "H9G2T4", "WBGene00010317", "Q94055", "WBGene00011767", "Q18006", "WBGene00015783", "Q18973", "WBGene00017054", "O76383", "WBGene00016061", "Q93839", "WBGene00010336", "O62137", "WBGene00008565", "O62139", "WBGene00008567", "O62140", "WBGene00008564", "P34355", "WBGene00008167", "Q20048", "WBGene00009439", "Q20992", "WBGene00019060", "Q95XN1", "WBGene00022150", "O17761", "WBGene00001157", "Q19058", "WBGene00017123", "Q20959", "WBGene00019022", "Q9NA25", "WBGene00003585", "Q17474", "WBGene00007143", "Q18426", "WBGene00004194", "Q19951", "WBGene00004198", "Q93930", "WBGene00004199", "Q18355", "WBGene00016318", "Q19189", "WBGene00004197", "Q19951", "WBGene00004198", "Q93930", "WBGene00004199", "Q18355", "WBGene00016318", "Q19189", "WBGene00004197", "Q18426", "WBGene00004194", "O76383", "WBGene00016061", "Q20992", "WBGene00019060", "B3WFZ3", "WBGene00020989", "O01862", "WBGene00020989", "O45003", "WBGene00020989", "Q9GYN3", "WBGene00020989", "Q9BIA9", "WBGene00015887", "Q17474", "WBGene00007143", "Q95XG9", "WBGene00022076", "Q19058", "WBGene00017123", "O17761", "WBGene00001157", "Q20048", "WBGene00009439", "O62138", "WBGene00008566", "Q18006", "WBGene00015783", "B1GRK5", "WBGene00018286", "Q18916", "WBGene00017012", "Q19878", "WBGene00009218", "Q20959", "WBGene00019022", "G5EFP8", "WBGene00012911", "A0A486WVT5", "WBGene00011850", "Q19564", "WBGene00017565", "O01739", "WBGene00017648", "O45307", "WBGene00008127", "Q18973", "WBGene00017054", "Q17499", "WBGene00007175", "Q95XN1", "WBGene00022150", "Q94055", "WBGene00011767", "Q9NA25", "WBGene00003585", "H9G2T4", "WBGene00010317", "O16249", "WBGene00018426", "Q9XW87", "WBGene00013541", "G5EGA6", "WBGene00010063", "P34355", "WBGene00008167", "Q93839", "WBGene00010336", "O62139", "WBGene00008567", "O62140", "WBGene00008564", "O62137", "WBGene00008565", "Q18122", "WBGene00016034", "P91148", "WBGene00003584", "Q8MYL7", "WBGene00013220" ] }, "reaction_10571740": { "compartment": "compartment_17947", "id": "reaction_10571740", "reactome": "R-CEL-9033236", "name": "PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10571708", "species_10571706" ], "products": [ "species_10571710" ], "modifiers": [], "additional_components": [ "Q19951", "WBGene00004198", "Q93930", "WBGene00004199", "Q18355", "WBGene00016318", "Q19189", "WBGene00004197", "Q18122", "WBGene00016034", "O16249", "WBGene00018426", "Q17499", "WBGene00007175", "A0A486WVT5", "WBGene00011850", "Q9BIA9", "WBGene00015887", "Q9XW87", "WBGene00013541", "P91148", "WBGene00003584", "G5EGA6", "WBGene00010063", "B3WFZ3", "WBGene00020989", "O01862", "WBGene00020989", "O45003", "WBGene00020989", "Q9GYN3", "WBGene00020989", "Q8MYL7", "WBGene00013220", "O01739", "WBGene00017648", "O45307", "WBGene00008127", "Q19564", "WBGene00017565", "Q95XG9", "WBGene00022076", "B1GRK5", "WBGene00018286", "O62138", "WBGene00008566", "Q18916", "WBGene00017012", "Q19878", "WBGene00009218", "G5EFP8", "WBGene00012911", "H9G2T4", "WBGene00010317", "Q94055", "WBGene00011767", "Q18006", "WBGene00015783", "Q18973", "WBGene00017054", "O76383", "WBGene00016061", "Q93839", "WBGene00010336", "O62137", "WBGene00008565", "O62139", "WBGene00008567", "O62140", "WBGene00008564", "P34355", "WBGene00008167", "Q20048", "WBGene00009439", "Q20992", "WBGene00019060", "Q95XN1", "WBGene00022150", "O17761", "WBGene00001157", "Q19058", "WBGene00017123", "Q20959", "WBGene00019022", "Q9NA25", "WBGene00003585", "Q17474", "WBGene00007143", "Q18426", "WBGene00004194", "Q18122", "WBGene00016034", "O16249", "WBGene00018426", "Q17499", "WBGene00007175", "A0A486WVT5", "WBGene00011850", "Q9BIA9", "WBGene00015887", "Q9XW87", "WBGene00013541", "P91148", "WBGene00003584", "G5EGA6", "WBGene00010063", "B3WFZ3", "WBGene00020989", "O01862", "WBGene00020989", "O45003", "WBGene00020989", "Q9GYN3", "WBGene00020989", "Q8MYL7", "WBGene00013220", "O01739", "WBGene00017648", "O45307", "WBGene00008127", "Q19564", "WBGene00017565", "Q95XG9", "WBGene00022076", "B1GRK5", "WBGene00018286", "O62138", "WBGene00008566", "Q18916", "WBGene00017012", "Q19878", "WBGene00009218", "G5EFP8", "WBGene00012911", "H9G2T4", "WBGene00010317", "Q94055", "WBGene00011767", "Q18006", "WBGene00015783", "Q18973", "WBGene00017054", "O76383", "WBGene00016061", "Q93839", "WBGene00010336", "O62137", "WBGene00008565", "O62139", "WBGene00008567", "O62140", "WBGene00008564", "P34355", "WBGene00008167", "Q20048", "WBGene00009439", "Q20992", "WBGene00019060", "Q95XN1", "WBGene00022150", "O17761", "WBGene00001157", "Q19058", "WBGene00017123", "Q20959", "WBGene00019022", "Q9NA25", "WBGene00003585", "Q17474", "WBGene00007143", "Q18426", "WBGene00004194", "Q19951", "WBGene00004198", "Q93930", "WBGene00004199", "Q18355", "WBGene00016318", "Q19189", "WBGene00004197" ] }, "reaction_10572195": { "compartment": "compartment_70101", "id": "reaction_10572195", "reactome": "R-CEL-9617595", "name": "SGTA binds mislocalized membrane protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10572191", "species_10571993" ], "products": [ "species_10572193" ], "modifiers": [], "additional_components": [ "Q19767", "WBGene00004898", "Q94057", "WBGene00044062", "Q95XH1", "WBGene00022077", "G5EBK2", "WBGene00014084", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q10651", "WBGene00000149", "Q21746", "WBGene00019893", "Q21746", "WBGene00019893", "Q19767", "WBGene00004898", "Q94057", "WBGene00044062", "Q95XH1", "WBGene00022077", "G5EBK2", "WBGene00014084", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q10651", "WBGene00000149" ] }, "reaction_10572045": { "compartment": "compartment_70101", "id": "reaction_10572045", "reactome": "R-CEL-9609921", "name": "SGTA binds Tail-anchored protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10572041", "species_10571993" ], "products": [ "species_10572043" ], "modifiers": [], "additional_components": [ "A0A486WWU7", "WBGene00000110", "O44555", "WBGene00000111", "Q93838", "WBGene00010337", "Q8MXH3", "WBGene00020374", "Q95XS2", "WBGene00021427", "O16000", "WBGene00006798", "Q19767", "WBGene00004898", "Q94057", "WBGene00044062", "Q95XH1", "WBGene00022077", "G5EBK2", "WBGene00014084", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q19967", "WBGene00001303", "Q20797", "WBGene00006373", "O01816", "WBGene00020931", "Q93315", "WBGene00007848", "A0A2K5ATR7", "WBGene00022450", "Q21746", "WBGene00019893", "Q21746", "WBGene00019893", "A0A486WWU7", "WBGene00000110", "O44555", "WBGene00000111", "Q93838", "WBGene00010337", "Q8MXH3", "WBGene00020374", "Q95XS2", "WBGene00021427", "O16000", "WBGene00006798", "Q19767", "WBGene00004898", "Q94057", "WBGene00044062", "Q95XH1", "WBGene00022077", "G5EBK2", "WBGene00014084", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q19967", "WBGene00001303", "Q20797", "WBGene00006373", "O01816", "WBGene00020931", "Q93315", "WBGene00007848", "A0A2K5ATR7", "WBGene00022450" ] }, "reaction_10528387": { "compartment": "compartment_876", "id": "reaction_10528387", "reactome": "R-CEL-888589", "name": "Release of GABA at the synapse", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74016", "species_10528368" ], "products": [ "species_10516825", "species_10516809", "species_10516744", "species_10516631", "species_10516823", "species_10528374", "species_352003", "species_10528372", "species_10516754", "species_10528370", "species_10528384" ], "modifiers": [ [ "species_10528368", "catalyst" ] ], "additional_components": [ "Q22366", "WBGene00006750", "G5EEN8", "WBGene00006454", "A5PEW5", "WBGene00004364", "P34815", "WBGene00006757", "Q9GUM7", "WBGene00022271", "O16000", "WBGene00006798", "G5EDB7", "WBGene00006762", "E5QCE7", "WBGene00001032", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q19767", "WBGene00004898", "Q94057", "WBGene00044062", "Q95XH1", "WBGene00022077", "G5EBK2", "WBGene00014084", "P09446", "WBGene00002005", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "Q94986", "WBGene00004267", "species_352003", "P34579", "WBGene00006783", "WBGene00004267", "species_74016", "G5EEN8", "WBGene00006454", "A5PEW5", "WBGene00004364", "Q94057", "WBGene00044062", "Q95XH1", "WBGene00022077", "G5EBK2", "WBGene00014084", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q19767", "WBGene00004898", "O16000", "WBGene00006798", "WBGene00022271", "WBGene00006757", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "WBGene00002005", "WBGene00001032", "WBGene00006750", "WBGene00006783", "G5EDB7", "WBGene00006762", "Q22366", "WBGene00006750", "G5EEN8", "WBGene00006454", "A5PEW5", "WBGene00004364", "P34815", "WBGene00006757", "Q9GUM7", "WBGene00022271", "O16000", "WBGene00006798", "G5EDB7", "WBGene00006762", "E5QCE7", "WBGene00001032", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q19767", "WBGene00004898", "Q94057", "WBGene00044062", "Q95XH1", "WBGene00022077", "G5EBK2", "WBGene00014084", "P09446", "WBGene00002005", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "Q94986", "WBGene00004267", "species_352003", "P34579", "WBGene00006783" ] }, "reaction_10528390": { "compartment": "compartment_70101", "id": "reaction_10528390", "reactome": "R-CEL-888592", "name": "Loading of GABA into clathrin sculpted GABA transport vesicle lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352011" ], "products": [ "species_428571" ], "modifiers": [ [ "species_10528334", "catalyst" ] ], "additional_components": [ "WBGene00006783" ] }, "reaction_10529192": { "compartment": "compartment_917758", "id": "reaction_10529192", "reactome": "R-CEL-917744", "name": "GABA loaded synaptic vesicle Docking and Priming", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10528366", "species_10516749", "species_10516744", "species_10516631", "species_10516739", "species_10516754" ], "products": [ "species_10528368" ], "modifiers": [ [ "species_10528366", "catalyst" ] ], "additional_components": [ "G5EDB7", "WBGene00006762", "E5QCE7", "WBGene00001032", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q19767", "WBGene00004898", "Q94057", "WBGene00044062", "Q95XH1", "WBGene00022077", "G5EBK2", "WBGene00014084", "P09446", "WBGene00002005", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "Q94986", "WBGene00004267", "species_352003", "P34579", "WBGene00006783", "WBGene00006798", "WBGene00022271", "WBGene00006757", "G5EEN8", "WBGene00006454", "A5PEW5", "WBGene00004364", "WBGene00006750", "Q22366", "WBGene00006750", "G5EEN8", "WBGene00006454", "A5PEW5", "WBGene00004364", "P34815", "WBGene00006757", "Q9GUM7", "WBGene00022271", "O16000", "WBGene00006798", "G5EDB7", "WBGene00006762", "E5QCE7", "WBGene00001032", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q19767", "WBGene00004898", "Q94057", "WBGene00044062", "Q95XH1", "WBGene00022077", "G5EBK2", "WBGene00014084", "P09446", "WBGene00002005", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "Q94986", "WBGene00004267", "species_352003", "P34579", "WBGene00006783", "G5EDB7", "WBGene00006762", "E5QCE7", "WBGene00001032", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q19767", "WBGene00004898", "Q94057", "WBGene00044062", "Q95XH1", "WBGene00022077", "G5EBK2", "WBGene00014084", "P09446", "WBGene00002005", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "Q94986", "WBGene00004267", "species_352003", "P34579", "WBGene00006783" ] }, "reaction_10528325": { "compartment": "compartment_917757", "id": "reaction_10528325", "reactome": "R-CEL-888577", "name": "Synthesis of GABA by GAD2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29404", "species_70106" ], "products": [ "species_352011", "species_113528" ], "modifiers": [ [ "species_10528322", "catalyst" ] ], "additional_components": [ "G5EDB7", "WBGene00006762" ] }, "reaction_10528313": { "compartment": "compartment_70101", "id": "reaction_10528313", "reactome": "R-CEL-888572", "name": "PXLP-K405-GAD1 decarboxylates L-Glu to form GABA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29404", "species_70106" ], "products": [ "species_352011", "species_113528" ], "modifiers": [ [ "species_10528310", "catalyst" ] ], "additional_components": [ "G5EDB7", "WBGene00006762" ] }, "reaction_10511628": { "compartment": "compartment_70101", "id": "reaction_10511628", "reactome": "R-CEL-174124", "name": "Dephosphorylation of phospho-Cdh1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10511618" ], "products": [ "species_111294", "species_10511606" ], "modifiers": [ [ "species_10511625", "catalyst" ] ], "additional_components": [ "WBGene00001510", "WBGene00001510" ] }, "reaction_10563824": { "compartment": "compartment_70101", "id": "reaction_10563824", "reactome": "R-CEL-6810843", "name": "Envoplakin binds periplakin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10563820", "species_10563818" ], "products": [ "species_10563822" ], "modifiers": [], "additional_components": [ "WBGene00006876", "WBGene00006876", "A0A1N7SYP3", "WBGene00006876" ] }, "reaction_10564246": { "compartment": "compartment_876", "id": "reaction_10564246", "reactome": "R-CEL-6814187", "name": "EVL:PPL heterodimer binds the inner surface of the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10563822", "species_983438" ], "products": [ "species_10563826" ], "modifiers": [], "additional_components": [ "A0A1N7SYP3", "WBGene00006876", "A0A1N7SYP3", "WBGene00006876" ] }, "reaction_10564473": { "compartment": "compartment_876", "id": "reaction_10564473", "reactome": "R-CEL-6814695", "name": "PERP binds desmosomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10564455", "species_10564469" ], "products": [ "species_10564471" ], "modifiers": [], "additional_components": [ "WBGene00006875", "Q19319", "WBGene00000396", "A0A1N7SYP3", "WBGene00006876", "Q10953", "WBGene00006943", "Q18825", "WBGene00000238", "O44326", "WBGene00001979", "Q9U308", "WBGene00002175", "Q19319", "WBGene00000396", "A0A1N7SYP3", "WBGene00006876", "Q10953", "WBGene00006943", "Q18825", "WBGene00000238", "O44326", "WBGene00001979", "Q9U308", "WBGene00002175", "G5ED30", "WBGene00006875" ] }, "reaction_10558492": { "compartment": "compartment_984", "id": "reaction_10558492", "reactome": "R-CEL-6789310", "name": "LIPs hydrolyse TG to DAG and RCOOH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_171126" ], "products": [ "species_174675", "species_6789319" ], "modifiers": [ [ "species_10558489", "catalyst" ] ], "additional_components": [ "O16956", "WBGene00020016", "Q20449", "WBGene00009773", "Q93789", "WBGene00010062", "O17766", "WBGene00008510", "O61866", "WBGene00022642", "Q94252", "WBGene00019376", "E2S7J2", "WBGene00021963", "Q9U276", "WBGene00013050" ] }, "reaction_10571492": { "compartment": "compartment_70101", "id": "reaction_10571492", "reactome": "R-CEL-9020270", "name": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_9024577" ], "products": [ "species_9024570" ], "modifiers": [ [ "species_10517863", "catalyst" ] ], "additional_components": [ "CHEBI:138615", "CHEBI:138616", "species_216785", "G5EFT4", "WBGene00016589" ] }, "reaction_10571494": { "compartment": "compartment_70101", "id": "reaction_10571494", "reactome": "R-CEL-9020271", "name": "GPX4-2 reduces 17(R)-Hp-DHA to 17(R)-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29450", "species_9024522" ], "products": [ "species_29356", "species_9024463", "species_111745" ], "modifiers": [ [ "species_10571475", "catalyst" ] ], "additional_components": [ "WBGene00019846" ] }, "reaction_10571484": { "compartment": "compartment_70101", "id": "reaction_10571484", "reactome": "R-CEL-9020252", "name": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_9024602" ], "products": [ "species_9024574" ], "modifiers": [ [ "species_10517863", "catalyst" ] ], "additional_components": [ "CHEBI:138179", "CHEBI:138614", "species_216785", "G5EFT4", "WBGene00016589" ] }, "reaction_10571490": { "compartment": "compartment_70101", "id": "reaction_10571490", "reactome": "R-CEL-9020258", "name": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_9024768" ], "products": [ "species_9024759" ], "modifiers": [ [ "species_10517863", "catalyst" ] ], "additional_components": [ "CHEBI:81565", "CHEBI:81564", "species_216785", "G5EFT4", "WBGene00016589" ] }, "reaction_10571496": { "compartment": "compartment_70101", "id": "reaction_10571496", "reactome": "R-CEL-9020273", "name": "GPX4-2 reduces 17(S)-Hp-DHA to 17(S)-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29450", "species_9024012" ], "products": [ "species_29356", "species_9024815", "species_111745" ], "modifiers": [ [ "species_10571475", "catalyst" ] ], "additional_components": [ "WBGene00019846" ] }, "reaction_10571486": { "compartment": "compartment_70101", "id": "reaction_10571486", "reactome": "R-CEL-9020253", "name": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(S)-HDHA to RvD3 or RvD4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_9024781" ], "products": [ "species_9024809" ], "modifiers": [ [ "species_10517863", "catalyst" ] ], "additional_components": [ "CHEBI:138649", "CHEBI:138648", "species_216785", "G5EFT4", "WBGene00016589" ] }, "reaction_10571488": { "compartment": "compartment_70101", "id": "reaction_10571488", "reactome": "R-CEL-9020257", "name": "LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_9024893" ], "products": [ "species_9024879" ], "modifiers": [ [ "species_10517863", "catalyst" ] ], "additional_components": [ "species_216785", "G5EFT4", "WBGene00016589" ] }, "reaction_10571541": { "compartment": "compartment_70101", "id": "reaction_10571541", "reactome": "R-CEL-9024890", "name": "LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_9024873" ], "products": [ "species_9024886" ], "modifiers": [ [ "species_10517863", "catalyst" ] ], "additional_components": [ "species_216785", "G5EFT4", "WBGene00016589" ] }, "reaction_10555584": { "compartment": "compartment_7660", "id": "reaction_10555584", "reactome": "R-CEL-5683792", "name": "p-T68-CHEK2 autophosphorylates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10555579" ], "products": [ "species_113582", "species_10502800" ], "modifiers": [ [ "species_10555579", "catalyst" ] ], "additional_components": [ "Q9U1Y5", "WBGene00000499", "WBGene00000499", "Q9U1Y5", "WBGene00000499" ] }, "reaction_10555635": { "compartment": "compartment_7660", "id": "reaction_10555635", "reactome": "R-CEL-5683964", "name": "ATM phosphorylates EYA1-4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10555610" ], "products": [ "species_113582", "species_10555619" ], "modifiers": [ [ "species_10555632", "catalyst" ] ], "additional_components": [ "WBGene00001377", "WBGene00001377", "Q9TYU5", "WBGene00007029", "Q23255", "WBGene00003405", "O44199", "WBGene00004296", "P62784", "WBGene00001875", "Q19649", "WBGene00017638", "Q23429", "WBGene00014240" ] }, "reaction_10555638": { "compartment": "compartment_7660", "id": "reaction_10555638", "reactome": "R-CEL-5683967", "name": "EYA1-4 dephosphorylates tyrosine Y142 of H2AFX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10555632" ], "products": [ "species_113550", "species_10555554" ], "modifiers": [ [ "species_10555619", "catalyst" ] ], "additional_components": [ "Q9TYU5", "WBGene00007029", "Q23255", "WBGene00003405", "O44199", "WBGene00004296", "P62784", "WBGene00001875", "Q19649", "WBGene00017638", "Q23429", "WBGene00014240", "P62784", "WBGene00001875", "Q19649", "WBGene00017638", "Q23429", "WBGene00014240", "Q9TYU5", "WBGene00007029", "Q23255", "WBGene00003405", "O44199", "WBGene00004296", "WBGene00001377" ] }, "reaction_10556984": { "compartment": "compartment_7660", "id": "reaction_10556984", "reactome": "R-CEL-5693536", "name": "ATM phosphorylates MDC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10556981" ], "products": [ "species_113582", "species_10555565" ], "modifiers": [ [ "species_10556981", "catalyst" ] ], "additional_components": [ "Q9U370", "WBGene00004031", "P62784", "WBGene00001875", "Q19649", "WBGene00017638", "Q23429", "WBGene00014240", "Q9TYU5", "WBGene00007029", "Q23255", "WBGene00003405", "O44199", "WBGene00004296", "P62784", "WBGene00001875", "Q19649", "WBGene00017638", "Q23429", "WBGene00014240", "Q9TYU5", "WBGene00007029", "Q23255", "WBGene00003405", "O44199", "WBGene00004296", "Q9U370", "WBGene00004031", "Q9U370", "WBGene00004031", "P62784", "WBGene00001875", "Q19649", "WBGene00017638", "Q23429", "WBGene00014240", "Q9TYU5", "WBGene00007029", "Q23255", "WBGene00003405", "O44199", "WBGene00004296" ] }, "reaction_10556989": { "compartment": "compartment_7660", "id": "reaction_10556989", "reactome": "R-CEL-5693549", "name": "ATM phosphorylates histone H2AFX on S139 at DNA DSBs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10556986" ], "products": [ "species_113582", "species_10555632" ], "modifiers": [ [ "species_10556986", "catalyst" ] ], "additional_components": [ "P62784", "WBGene00001875", "Q23429", "WBGene00014240", "Q19649", "WBGene00017638", "Q9TYU5", "WBGene00007029", "Q23255", "WBGene00003405", "O44199", "WBGene00004296", "Q9TYU5", "WBGene00007029", "Q23255", "WBGene00003405", "O44199", "WBGene00004296", "P62784", "WBGene00001875", "Q19649", "WBGene00017638", "Q23429", "WBGene00014240", "P62784", "WBGene00001875", "Q23429", "WBGene00014240", "Q19649", "WBGene00017638", "Q9TYU5", "WBGene00007029", "Q23255", "WBGene00003405", "O44199", "WBGene00004296" ] }, "reaction_10555581": { "compartment": "compartment_7660", "id": "reaction_10555581", "reactome": "R-CEL-5683774", "name": "p-T68-CHEK2 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10555577" ], "products": [ "species_10555579" ], "modifiers": [], "additional_components": [ "WBGene00000499", "Q9U1Y5", "WBGene00000499" ] }, "reaction_10555647": { "compartment": "compartment_7660", "id": "reaction_10555647", "reactome": "R-CEL-5683986", "name": "APBB1 and MAPK8 bind diphosphorylated H2AFX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10555643", "species_10510872", "species_10555632" ], "products": [ "species_10555645" ], "modifiers": [], "additional_components": [ "WBGene00001410", "WBGene00002178", "Q9TYU5", "WBGene00007029", "Q23255", "WBGene00003405", "O44199", "WBGene00004296", "P62784", "WBGene00001875", "Q19649", "WBGene00017638", "Q23429", "WBGene00014240", "Q9TYU5", "WBGene00007029", "Q23255", "WBGene00003405", "O44199", "WBGene00004296", "P62784", "WBGene00001875", "Q19649", "WBGene00017638", "Q23429", "WBGene00014240", "Q8WQG9", "WBGene00002178", "Q9BKZ9", "WBGene00001410" ] }, "reaction_10556991": { "compartment": "compartment_7660", "id": "reaction_10556991", "reactome": "R-CEL-5693583", "name": "MDC1 associates with gamma-H2AFX at nuclear foci", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10555554", "species_10556979" ], "products": [ "species_10556981" ], "modifiers": [], "additional_components": [ "P62784", "WBGene00001875", "Q19649", "WBGene00017638", "Q23429", "WBGene00014240", "Q9TYU5", "WBGene00007029", "Q23255", "WBGene00003405", "O44199", "WBGene00004296", "Q9U370", "WBGene00004031", "Q9U370", "WBGene00004031", "P62784", "WBGene00001875", "Q19649", "WBGene00017638", "Q23429", "WBGene00014240", "Q9TYU5", "WBGene00007029", "Q23255", "WBGene00003405", "O44199", "WBGene00004296" ] }, "reaction_10566033": { "compartment": "compartment_70101", "id": "reaction_10566033", "reactome": "R-CEL-8863723", "name": "COP9 and TOR1 deneddylate STON2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10566028" ], "products": [ "species_10566026", "species_10566008", "species_10565943", "species_10556642" ], "modifiers": [ [ "species_10566028", "catalyst" ] ], "additional_components": [ "P90761", "WBGene00006777", "Q95NU5", "WBGene00003870", "Q9N359", "WBGene00000816", "P91001", "WBGene00000817", "Q95PZ0", "WBGene00000818", "Q9GS00", "WBGene00000813", "O01422", "WBGene00000814", "Q9N425", "WBGene00000815", "Q9N359", "WBGene00000816", "P91001", "WBGene00000817", "Q95PZ0", "WBGene00000818", "Q9GS00", "WBGene00000813", "O01422", "WBGene00000814", "Q9N425", "WBGene00000815", "Q95NU5", "WBGene00003870", "WBGene00006777", "WBGene00003587", "P90761", "WBGene00006777", "Q95NU5", "WBGene00003870", "Q9N359", "WBGene00000816", "P91001", "WBGene00000817", "Q95PZ0", "WBGene00000818", "Q9GS00", "WBGene00000813", "O01422", "WBGene00000814", "Q9N425", "WBGene00000815" ] }, "reaction_10566256": { "compartment": "compartment_876", "id": "reaction_10566256", "reactome": "R-CEL-8866277", "name": "AP-2 directly binds some endocytic cargo", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10548814", "species_10566250" ], "products": [ "species_10566252" ], "modifiers": [ [ "species_10566254", "inhibitor" ] ], "additional_components": [ "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q95QV2", "WBGene00000477", "Q19625", "WBGene00003412", "P34711", "WBGene00006756", "Q9XTT3", "WBGene00013039", "Q95QV2", "WBGene00000477", "Q19625", "WBGene00003412", "P34711", "WBGene00006756", "Q9XTT3", "WBGene00013039", "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "P35603", "WBGene00001082", "Q19123", "WBGene00000157" ] }, "reaction_10566272": { "compartment": "compartment_876", "id": "reaction_10566272", "reactome": "R-CEL-8866283", "name": "ARBB recruits GPCRs into clathrin-coated pits", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10566213", "species_10565777" ], "products": [ "species_10566270" ], "modifiers": [ [ "species_10566234", "inhibitor" ] ], "additional_components": [ "Q9N532", "WBGene00003238", "G5EDV1", "WBGene00003006", "P34889", "WBGene00000858", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "Q9U7D5", "WBGene00001519", "P51485", "WBGene00000195", "G5ECQ3", "WBGene00004762", "Q20483", "WBGene00018516", "Q9BIF4", "WBGene00001224", "species_179856", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "Q9TXS0", "WBGene00018974", "Q9N489", "WBGene00022453", "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "Q19123", "WBGene00000157", "P35603", "WBGene00001082", "A0A0K3AS36", "Y116A8C.36d", "G5ECQ3", "WBGene00004762", "Q20483", "WBGene00018516", "Q9BIF4", "WBGene00001224", "species_179856", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "Q9TXS0", "WBGene00018974", "Q9N489", "WBGene00022453", "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "Q19123", "WBGene00000157", "P35603", "WBGene00001082", "A0A0K3AS36", "Y116A8C.36d", "Q9N532", "WBGene00003238", "G5EDV1", "WBGene00003006", "P34889", "WBGene00000858", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "Q9U7D5", "WBGene00001519", "P51485", "WBGene00000195", "Q9BIF4", "WBGene00001224", "Q18453", "WBGene00004682", "Q9BI71", "WBGene00001329", "G5EFF7", "WBGene00008852" ] }, "reaction_10566035": { "compartment": "compartment_70101", "id": "reaction_10566035", "reactome": "R-CEL-8863727", "name": "STON2 is neddylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10565943", "species_10556642" ], "products": [ "species_10565990" ], "modifiers": [], "additional_components": [ "WBGene00006777", "WBGene00003587", "WBGene00006777" ] }, "reaction_10566371": { "compartment": "compartment_876", "id": "reaction_10566371", "reactome": "R-CEL-8867613", "name": "PICALM binds R-SNAREs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10566365", "species_10566363" ], "products": [ "species_10566369" ], "modifiers": [], "additional_components": [ "WBGene00006751", "Q95XH1", "WBGene00022077", "G5EBK2", "WBGene00014084", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q19767", "WBGene00004898", "Q94057", "WBGene00044062", "Q95XH1", "WBGene00022077", "G5EBK2", "WBGene00014084", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q19767", "WBGene00004898", "Q94057", "WBGene00044062", "Q9XZI6", "WBGene00006751" ] }, "reaction_10573106": { "compartment": "compartment_70101", "id": "reaction_10573106", "reactome": "R-CEL-9681616", "name": "AP2 binds chlorpromazine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9648300", "species_10548814" ], "products": [ "species_10566254" ], "modifiers": [], "additional_components": [ "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "P35603", "WBGene00001082", "Q19123", "WBGene00000157" ] }, "reaction_10566215": { "compartment": "compartment_876", "id": "reaction_10566215", "reactome": "R-CEL-8866269", "name": "ARRB bind GPCRs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10521710", "species_10566211" ], "products": [ "species_10566213" ], "modifiers": [], "additional_components": [ "WBGene00000195", "Q9N532", "WBGene00003238", "G5EDV1", "WBGene00003006", "P34889", "WBGene00000858", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "Q9U7D5", "WBGene00001519", "Q9N532", "WBGene00003238", "G5EDV1", "WBGene00003006", "P34889", "WBGene00000858", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "Q9U7D5", "WBGene00001519", "P51485", "WBGene00000195" ] }, "reaction_10565949": { "compartment": "compartment_876", "id": "reaction_10565949", "reactome": "R-CEL-8863463", "name": "STON2 binds SYT proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10565943", "species_10565938" ], "products": [ "species_10565947" ], "modifiers": [], "additional_components": [ "WBGene00006777", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "P90761", "WBGene00006777" ] }, "reaction_10566268": { "compartment": "compartment_876", "id": "reaction_10566268", "reactome": "R-CEL-8866279", "name": "Epsin family proteins bind ubiquitinated cargo", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10566232", "species_10566264" ], "products": [ "species_10566266" ], "modifiers": [], "additional_components": [ "Q9BIF4", "WBGene00001224", "Q18453", "WBGene00004682", "Q9BI71", "WBGene00001329", "Q19019", "WBGene00004829", "Q9BIF4", "WBGene00001224", "P24348", "WBGene00002299", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "B1V8A0", "WBGene00006791", "P29355", "WBGene00004774", "Q17796", "WBGene00004101", "O01498", "WBGene00004109", "Q18453", "WBGene00004682", "Q9BI71", "WBGene00001329", "Q9BIF4", "WBGene00001224", "Q18453", "WBGene00004682", "Q9BI71", "WBGene00001329", "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "B1V8A0", "WBGene00006791", "P29355", "WBGene00004774", "Q17796", "WBGene00004101", "O01498", "WBGene00004109" ] }, "reaction_10566236": { "compartment": "compartment_70101", "id": "reaction_10566236", "reactome": "R-CEL-8866275", "name": "UBQLNs bind UIM-containing adaptor proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10566220", "species_10566232" ], "products": [ "species_10566234" ], "modifiers": [], "additional_components": [ "WBGene00008852", "Q9BIF4", "WBGene00001224", "Q18453", "WBGene00004682", "Q9BI71", "WBGene00001329", "Q9BIF4", "WBGene00001224", "Q18453", "WBGene00004682", "Q9BI71", "WBGene00001329", "G5EFF7", "WBGene00008852" ] }, "reaction_10565967": { "compartment": "compartment_876", "id": "reaction_10565967", "reactome": "R-CEL-8863472", "name": "DAB2 binds LRP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10565951", "species_10565963" ], "products": [ "species_10565965" ], "modifiers": [], "additional_components": [ "WBGene00000894", "Q21496", "WBGene00020010", "Q21948", "WBGene00020010", "Q21496", "WBGene00020010", "Q21948", "WBGene00020010", "A0A486WXX8", "WBGene00000894" ] }, "reaction_10566030": { "compartment": "compartment_70101", "id": "reaction_10566030", "reactome": "R-CEL-8863721", "name": "NEDD8-STON binds TOR1 hexamer and COP9 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10566026", "species_10566008", "species_10565990" ], "products": [ "species_10566028" ], "modifiers": [], "additional_components": [ "Q9N359", "WBGene00000816", "P91001", "WBGene00000817", "Q95PZ0", "WBGene00000818", "Q9GS00", "WBGene00000813", "O01422", "WBGene00000814", "Q9N425", "WBGene00000815", "Q95NU5", "WBGene00003870", "WBGene00006777", "P90761", "WBGene00006777", "Q95NU5", "WBGene00003870", "Q9N359", "WBGene00000816", "P91001", "WBGene00000817", "Q95PZ0", "WBGene00000818", "Q9GS00", "WBGene00000813", "O01422", "WBGene00000814", "Q9N425", "WBGene00000815" ] }, "reaction_10506050": { "compartment": "compartment_70101", "id": "reaction_10506050", "reactome": "R-CEL-73571", "name": "CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111628", "species_70106" ], "products": [ "species_29356", "species_76630" ], "modifiers": [ [ "species_10506047", "catalyst" ] ], "additional_components": [ "Q18990", "WBGene00004259" ] }, "reaction_10506053": { "compartment": "compartment_70101", "id": "reaction_10506053", "reactome": "R-CEL-73573", "name": "CAD hexamer transforms CAP to N-carb-L-Asp", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111647", "species_29448" ], "products": [ "species_111628", "species_29372" ], "modifiers": [ [ "species_10506047", "catalyst" ] ], "additional_components": [ "Q18990", "WBGene00004259" ] }, "reaction_10506056": { "compartment": "compartment_70101", "id": "reaction_10506056", "reactome": "R-CEL-73577", "name": "CAD hexamer transforms L-Gln to CAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_111627", "species_113592", "species_29472" ], "products": [ "species_111647", "species_29372", "species_29404", "species_29370" ], "modifiers": [ [ "species_10506047", "catalyst" ] ], "additional_components": [ "Q18990", "WBGene00004259" ] }, "reaction_10506040": { "compartment": "compartment_70101", "id": "reaction_10506040", "reactome": "R-CEL-73569", "name": "DHODH:FMN oxidises (S)-DHO to orotate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73663", "species_76630" ], "products": [ "species_76632", "species_76633" ], "modifiers": [ [ "species_10506037", "catalyst" ] ], "additional_components": [ "O01815", "WBGene00020932", "species_73524" ] }, "reaction_10506027": { "compartment": "compartment_70101", "id": "reaction_10506027", "reactome": "R-CEL-73564", "name": "UMPS dimer decarboxylates OMP to UMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111629" ], "products": [ "species_109402", "species_113528" ], "modifiers": [ [ "species_10506024", "catalyst" ] ], "additional_components": [ "G5EDZ2", "WBGene00011559" ] }, "reaction_10506030": { "compartment": "compartment_70101", "id": "reaction_10506030", "reactome": "R-CEL-73567", "name": "UMPS dimer transfers phoshoribosyl group to ORO to form OMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73566", "species_76632" ], "products": [ "species_111294", "species_111629" ], "modifiers": [ [ "species_10506024", "catalyst" ] ], "additional_components": [ "G5EDZ2", "WBGene00011559" ] }, "reaction_10508834": { "compartment": "compartment_70101", "id": "reaction_10508834", "reactome": "R-CEL-111285", "name": "Formation of phosphoribosyl pyrophosphate amidotransferase tetramer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10506404" ], "products": [ "species_10508832" ], "modifiers": [ [ "species_113578", "catalyst" ], [ "species_29602", "catalyst" ], [ "species_76577", "catalyst" ] ], "additional_components": [ "Q22134", "WBGene00011407", "CHEBI:17909", "species_113531", "Q22134", "WBGene00011407", "CHEBI:17909", "species_113531" ] }, "reaction_10508866": { "compartment": "compartment_70101", "id": "reaction_10508866", "reactome": "R-CEL-111524", "name": "IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_29448", "species_29602" ], "products": [ "species_29372", "species_29420", "species_35141" ], "modifiers": [ [ "species_10508863", "catalyst" ], [ "species_29420", "inhibitor" ], [ "species_30014", "inhibitor" ], [ "species_113578", "inhibitor" ], [ "species_35141", "inhibitor" ] ], "additional_components": [ "P91134", "WBGene00016509", "species_114632" ] }, "reaction_10508836": { "compartment": "compartment_70101", "id": "reaction_10508836", "reactome": "R-CEL-111289", "name": "Dissociation of phosphoribosyl pyrophosphate amidotransferase tetramer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508832" ], "products": [ "species_10506404" ], "modifiers": [ [ "species_73566", "catalyst" ] ], "additional_components": [ "Q22134", "WBGene00011407", "CHEBI:17909", "species_113531", "Q22134", "WBGene00011407", "CHEBI:17909", "species_113531" ] }, "reaction_10506340": { "compartment": "compartment_70101", "id": "reaction_10506340", "reactome": "R-CEL-73792", "name": "XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_111584", "species_29472" ], "products": [ "species_111294", "species_29404", "species_113578", "species_76577" ], "modifiers": [ [ "species_10506337", "catalyst" ] ], "additional_components": [ "WBGene00010912" ] }, "reaction_10506407": { "compartment": "compartment_70101", "id": "reaction_10506407", "reactome": "R-CEL-73815", "name": "5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73566", "species_29356", "species_29472" ], "products": [ "species_111294", "species_111292", "species_29404" ], "modifiers": [ [ "species_10506404", "catalyst" ] ], "additional_components": [ "Q22134", "WBGene00011407", "CHEBI:17909", "species_113531" ] }, "reaction_10506376": { "compartment": "compartment_70101", "id": "reaction_10506376", "reactome": "R-CEL-73800", "name": "SAICAR => AICAR + Fumarate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111399" ], "products": [ "species_29586", "species_111409" ], "modifiers": [ [ "species_10506373", "catalyst" ] ], "additional_components": [ "Q21774", "WBGene00011064" ] }, "reaction_10506409": { "compartment": "compartment_70101", "id": "reaction_10506409", "reactome": "R-CEL-73828", "name": "adenylosuccinate => adenosine 5'-monophosphate + fumarate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_35141" ], "products": [ "species_29586", "species_76577" ], "modifiers": [ [ "species_10506373", "catalyst" ] ], "additional_components": [ "Q21774", "WBGene00011064" ] }, "reaction_10506352": { "compartment": "compartment_70101", "id": "reaction_10506352", "reactome": "R-CEL-73794", "name": "IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_29602", "species_29360" ], "products": [ "species_70106", "species_111584", "species_73473" ], "modifiers": [ [ "species_10506347", "catalyst" ], [ "species_111584", "inhibitor" ], [ "species_10506350", "inhibitor" ] ], "additional_components": [ "Q9GZH3", "WBGene00020682", "Q9GZH3", "WBGene00020682" ] }, "reaction_10506386": { "compartment": "compartment_70101", "id": "reaction_10506386", "reactome": "R-CEL-73805", "name": "CAIR + Aspartate + ATP => SAICAR + ADP + Pi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_29448", "species_111395" ], "products": [ "species_29372", "species_29370", "species_111399" ], "modifiers": [ [ "species_10506383", "catalyst" ] ], "additional_components": [ "Q10457", "WBGene00015116" ] }, "reaction_10506389": { "compartment": "compartment_70101", "id": "reaction_10506389", "reactome": "R-CEL-73806", "name": "AIR + CO2 => CAIR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111370", "species_113528" ], "products": [ "species_111395" ], "modifiers": [ [ "species_10506383", "catalyst" ] ], "additional_components": [ "Q10457", "WBGene00015116" ] }, "reaction_10506363": { "compartment": "compartment_70101", "id": "reaction_10506363", "reactome": "R-CEL-73797", "name": "FAICAR => IMP + H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111427" ], "products": [ "species_29356", "species_29602" ], "modifiers": [ [ "species_10506360", "catalyst" ] ], "additional_components": [ "Q95QQ4", "WBGene00016957" ] }, "reaction_10558365": { "compartment": "compartment_70101", "id": "reaction_10558365", "reactome": "R-CEL-6788912", "name": "LHPP:Mg2+ dimer hydrolyses PPi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111294", "species_29356" ], "products": [ "species_29372" ], "modifiers": [ [ "species_10558362", "catalyst" ] ], "additional_components": [ "species_114632", "O01926", "WBGene00007548" ] }, "reaction_10506397": { "compartment": "compartment_70101", "id": "reaction_10506397", "reactome": "R-CEL-73812", "name": "FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_111354", "species_113592", "species_29472" ], "products": [ "species_29372", "species_29404", "species_29370", "species_111369" ], "modifiers": [ [ "species_10506394", "catalyst" ] ], "additional_components": [ "WBGene00008654" ] }, "reaction_10573084": { "compartment": "compartment_70101", "id": "reaction_10573084", "reactome": "R-CEL-9678749", "name": "IMPDH tetramers binds IMPDH inhibitors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9678719", "species_10506347" ], "products": [ "species_10506350" ], "modifiers": [], "additional_components": [ "Q9GZH3", "WBGene00020682", "Q9GZH3", "WBGene00020682" ] }, "reaction_10506366": { "compartment": "compartment_70101", "id": "reaction_10506366", "reactome": "R-CEL-73798", "name": "AICAR + 10-Formyl-THF => FAICAR + THF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_419151", "species_111409" ], "products": [ "species_111355", "species_111427" ], "modifiers": [ [ "species_10506360", "catalyst" ] ], "additional_components": [ "Q95QQ4", "WBGene00016957" ] }, "reaction_10573092": { "compartment": "compartment_876", "id": "reaction_10573092", "reactome": "R-CEL-9679740", "name": "ITGA4:ITGB1 binds natalizumab", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10514207", "species_9679737" ], "products": [ "species_10573090" ], "modifiers": [], "additional_components": [ "Q27874", "WBGene00003930", "P34446", "WBGene00003929", "Q27874", "WBGene00003930", "P34446", "WBGene00003929" ] }, "reaction_10515321": { "compartment": "compartment_876", "id": "reaction_10515321", "reactome": "R-CEL-202723", "name": "Integrin alpha5beta1 binds FN1 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_266099", "species_10515317", "species_10515313" ], "products": [ "species_10515319" ], "modifiers": [], "additional_components": [ "P34446", "WBGene00003929", "Q27874", "WBGene00003930", "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769", "P34446", "WBGene00003929", "Q27874", "WBGene00003930", "species_266099" ] }, "reaction_10515290": { "compartment": "compartment_876", "id": "reaction_10515290", "reactome": "R-CEL-202710", "name": "MERTK receptor binds ligands (Gas6 or Protein S)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10515286", "species_10515280" ], "products": [ "species_10515288" ], "modifiers": [], "additional_components": [ "G5EFX3", "WBGene00013416", "Q9XWD6", "WBGene00000415", "WBGene00008711", "Q9XVQ7", "WBGene00008711", "G5EFX3", "WBGene00013416", "Q9XWD6", "WBGene00000415" ] }, "reaction_10545950": { "compartment": "compartment_876", "id": "reaction_10545950", "reactome": "R-CEL-2870221", "name": "E-selectin binds E-selectin ligand", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10545946", "species_10545941" ], "products": [ "species_10545948" ], "modifiers": [], "additional_components": [ "WBGene00008800", "Q18849", "WBGene00009500", "Q22328", "WBGene00002976", "A0A1N7SYP5", "WBGene00009500", "Q18849", "WBGene00009500", "Q22328", "WBGene00002976", "A0A1N7SYP5", "WBGene00009500", "Q19459", "WBGene00008800" ] }, "reaction_10572733": { "compartment": "compartment_17957", "id": "reaction_10572733", "reactome": "R-CEL-9650473", "name": "SERPING1 is secreted", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10572731" ], "products": [ "species_10526610" ], "modifiers": [], "additional_components": [ "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "A9Z1L1", "WBGene00005648", "G5ECY2", "WBGene00005644", "Q19651", "WBGene00005649", "A9Z1L1", "WBGene00005648", "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q18287", "WBGene00016187" ] }, "reaction_10509775": { "compartment": "compartment_984", "id": "reaction_10509775", "reactome": "R-CEL-140806", "name": "SERPINC1 binds SERPINC1 activators", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509755", "species_9693058" ], "products": [ "species_10509773" ], "modifiers": [], "additional_components": [ "G5ECY2", "WBGene00005644", "Q18287", "WBGene00016187", "G5EE40", "WBGene00005642", "Q19651", "WBGene00005649", "G5EFH4", "WBGene00005647", "A9Z1L1", "WBGene00005648", "O17365", "WBGene00005643", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "A9Z1L1", "WBGene00005648", "G5ECY2", "WBGene00005644" ] }, "reaction_10566692": { "compartment": "compartment_12045", "id": "reaction_10566692", "reactome": "R-CEL-8869206", "name": "PAFAH2 hydrolyses PAF to lyso-PAF and acetate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_8869214" ], "products": [ "species_29416", "species_8869207" ], "modifiers": [ [ "species_10566689", "catalyst" ] ], "additional_components": [ "G5EGT1", "WBGene00003906", "Q22943", "WBGene00003907" ] }, "reaction_10523812": { "compartment": "compartment_70101", "id": "reaction_10523812", "reactome": "R-CEL-432148", "name": "Fgr may phosphorylate p38 MAPK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10523344" ], "products": [ "species_10512654", "species_29370" ], "modifiers": [ [ "species_10523809", "catalyst" ] ], "additional_components": [ "WBGene00004055", "WBGene00004055", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635" ] }, "reaction_10509648": { "compartment": "compartment_70101", "id": "reaction_10509648", "reactome": "R-CEL-114683", "name": "Phosphorylation of Platelet Sec-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10509637" ], "products": [ "species_10509645", "species_29370" ], "modifiers": [ [ "species_10509553", "catalyst" ] ], "additional_components": [ "P34815", "WBGene00006757", "O44412", "WBGene00020298", "O44412", "WBGene00020298", "P34815", "WBGene00006757", "species_114519", "P90980", "WBGene00004033", "species_33625", "species_74016" ] }, "reaction_10509555": { "compartment": "compartment_70101", "id": "reaction_10509555", "reactome": "R-CEL-114553", "name": "Activation of conventional Protein Kinase C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_33625", "species_114519", "species_10509044", "species_74016" ], "products": [ "species_10509553" ], "modifiers": [ [ "species_114519", "catalyst" ] ], "additional_components": [ "WBGene00004033", "species_114519", "P90980", "WBGene00004033", "species_33625", "species_74016" ] }, "reaction_10526786": { "compartment": "compartment_876", "id": "reaction_10526786", "reactome": "R-CEL-481010", "name": "Surface deployment of platelet dense granule membrane components", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10526770" ], "products": [ "species_10526784" ], "modifiers": [], "additional_components": [ "G5EBS5", "WBGene00000089", "Q9GYK0", "WBGene00015471", "Q11117", "WBGene00003053", "Q17441", "WBGene00006646", "Q22328", "WBGene00002976", "Q11117", "WBGene00003053", "Q9GYK0", "WBGene00015471", "Q17441", "WBGene00006646", "Q22328", "WBGene00002976", "G5EBS5", "WBGene00000089" ] }, "reaction_10526658": { "compartment": "compartment_876", "id": "reaction_10526658", "reactome": "R-CEL-481007", "name": "Exocytosis of platelet alpha granule contents", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10526516" ], "products": [ "species_10526656" ], "modifiers": [], "additional_components": [ "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769", "A9Z1L1", "WBGene00005648", "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "Q09387", "WBGene00019944", "Q9N413", "WBGene00004249", "K8F7Z5", "WBGene00008735", "Q7YTU0", "WBGene00013969", "G5EFX3", "WBGene00013416", "Q9XWD6", "WBGene00000415", "P34714", "WBGene00003893", "H2KZY5", "WBGene00018533", "G5EEL5", "WBGene00000936", "G5EBY8", "WBGene00006852", "Q21154", "WBGene00019333", "Q18685", "WBGene00006836", "Q10651", "WBGene00000149", "Q18245", "WBGene00007764", "Q23580", "WBGene00022789", "Q9GZE9", "WBGene00017719", "Q9XXG5", "WBGene00006598", "O45271", "WBGene00006597", "Q95NU5", "WBGene00003870", "Q23158", "WBGene00000228", "Q22174", "WBGene00011449", "P91917", "WBGene00012344", "P46563", "WBGene00017166", "P54216", "WBGene00011474", "Q9XWD6", "WBGene00000415", "G5EFX3", "WBGene00013416", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "A9Z1L1", "WBGene00005648", "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "H2KZY5", "WBGene00018533", "K8F7Z5", "WBGene00008735", "Q7YTU0", "WBGene00013969", "Q21154", "WBGene00019333", "Q22174", "WBGene00011449", "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769", "Q9N413", "WBGene00004249", "P91917", "WBGene00012344", "Q23158", "WBGene00000228", "Q09387", "WBGene00019944", "G5EEL5", "WBGene00000936", "G5EBY8", "WBGene00006852", "P34714", "WBGene00003893", "Q10651", "WBGene00000149", "Q18245", "WBGene00007764", "Q23580", "WBGene00022789", "O45271", "WBGene00006597", "Q95NU5", "WBGene00003870", "Q9XXG5", "WBGene00006598", "P46563", "WBGene00017166", "P54216", "WBGene00011474", "Q18685", "WBGene00006836", "Q9GZE9", "WBGene00017719" ] }, "reaction_10523396": { "compartment": "compartment_114584", "id": "reaction_10523396", "reactome": "R-CEL-429157", "name": "ABCC4 accumulation of dense granule contents", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29370" ], "products": [ "species_114565" ], "modifiers": [ [ "species_10523393", "catalyst" ] ], "additional_components": [ "WBGene00003412" ] }, "reaction_10526744": { "compartment": "compartment_876", "id": "reaction_10526744", "reactome": "R-CEL-481009", "name": "Exocytosis of platelet dense granule content", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10526706" ], "products": [ "species_10526742" ], "modifiers": [], "additional_components": [ "species_29438", "species_113582", "species_114632", "O02108", "WBGene00021097", "H2L0F2", "WBGene00019497", "species_29358", "O16454", "WBGene00007055", "Q688B0", "WBGene00019786", "species_29372", "Q19651", "WBGene00005649", "A9Z1L1", "WBGene00005648", "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "species_74016", "A0A1N7SYP5", "WBGene00009500", "Q18849", "WBGene00009500", "Q22328", "WBGene00002976", "species_380585", "species_29420", "species_113541", "species_74016", "Q19651", "WBGene00005649", "A9Z1L1", "WBGene00005648", "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "species_29438", "species_113582", "species_113541", "species_114632", "A0A1N7SYP5", "WBGene00009500", "Q18849", "WBGene00009500", "Q22328", "WBGene00002976", "species_29358", "H2L0F2", "WBGene00019497", "O02108", "WBGene00021097", "O16454", "WBGene00007055", "Q688B0", "WBGene00019786", "species_380585", "species_29372", "species_29420" ] }, "reaction_10526856": { "compartment": "compartment_876", "id": "reaction_10526856", "reactome": "R-CEL-481044", "name": "Surface deployment of platelet alpha granule membrane components", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10526830" ], "products": [ "species_10526854" ], "modifiers": [], "additional_components": [ "Q9N4L6", "WBGene00022836", "Q9XVI4", "WBGene00006633", "P34616", "WBGene00000395", "U4PMB9", "WBGene00021362", "Q22328", "WBGene00002976", "O16521", "WBGene00020268", "O16522", "WBGene00020267", "Q10651", "WBGene00000149", "P91855", "WBGene00009174", "Q7YTU0", "WBGene00013969", "Q9XVI4", "WBGene00006633", "Q10651", "WBGene00000149", "O16522", "WBGene00020267", "O16521", "WBGene00020268", "Q7YTU0", "WBGene00013969", "P34616", "WBGene00000395", "U4PMB9", "WBGene00021362", "P91855", "WBGene00009174", "Q22328", "WBGene00002976", "Q9N4L6", "WBGene00022836" ] }, "reaction_10518043": { "compartment": "compartment_161320", "id": "reaction_10518043", "reactome": "R-CEL-351341", "name": "Exocytosis of Proactivator polypeptide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10518035" ], "products": [ "species_10518041" ], "modifiers": [], "additional_components": [ "Q18607", "WBGene00016642", "Q18276", "WBGene00004995", "Q18607", "WBGene00016642", "Q18276", "WBGene00004995" ] }, "reaction_10527071": { "compartment": "compartment_70101", "id": "reaction_10527071", "reactome": "R-CEL-482772", "name": "Release of platelet cytosolic components", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10526977" ], "products": [ "species_10527069" ], "modifiers": [], "additional_components": [ "P19826", "WBGene00000942", "H2KYR1", "WBGene00006924", "O44412", "WBGene00020298", "P34815", "WBGene00006757", "P52274", "WBGene00006534", "H2L2E8", "WBGene00006528", "P91910", "WBGene00003175", "O18154", "WBGene00006533", "P34690", "WBGene00006529", "G5EDD4", "WBGene00006530", "O17939", "WBGene00010685", "P0DM41", "WBGene00000063", "P0DM42", "WBGene00000065", "P10984", "WBGene00000064", "P10986", "WBGene00000066", "G5EGK1", "WBGene00006771", "P34697", "WBGene00004930", "Q27538", "WBGene00007036", "Q09936", "WBGene00016898", "Q23050", "WBGene00020808", "G5EFB5", "WBGene00000777", "O44788", "WBGene00000778", "D0VWL6", "WBGene00016006", "U4PBJ9", "WBGene00022048", "Q11083", "WBGene00020378", "P04630", "WBGene00000285", "G5EF37", "WBGene00003934", "A0A2C9C3L3", "WBGene00020378", "Q18136", "WBGene00006861", "Q09665", "WBGene00006583", "O02159", "WBGene00020378", "G5EDZ8", "WBGene00000288", "Q94288", "WBGene00000287", "Q09980", "WBGene00017394", "O16305", "WBGene00000552", "G5EEG0", "WBGene00000286", "Q20318", "WBGene00003034", "Q9N3B0", "WBGene00021888", "H2KYR1", "WBGene00006924", "D0VWL6", "WBGene00016006", "U4PBJ9", "WBGene00022048", "A0A2C9C3L3", "WBGene00020378", "Q09980", "WBGene00017394", "G5EDZ8", "WBGene00000288", "Q11083", "WBGene00020378", "G5EEG0", "WBGene00000286", "Q18136", "WBGene00006861", "G5EF37", "WBGene00003934", "Q94288", "WBGene00000287", "O02159", "WBGene00020378", "O16305", "WBGene00000552", "P04630", "WBGene00000285", "Q09665", "WBGene00006583", "G5EGK1", "WBGene00006771", "P19826", "WBGene00000942", "O17939", "WBGene00010685", "G5EDD4", "WBGene00006530", "H2L2E8", "WBGene00006528", "O18154", "WBGene00006533", "P34690", "WBGene00006529", "P52274", "WBGene00006534", "P91910", "WBGene00003175", "O44412", "WBGene00020298", "P34815", "WBGene00006757", "Q27538", "WBGene00007036", "P34697", "WBGene00004930", "Q20318", "WBGene00003034", "G5EFB5", "WBGene00000777", "O44788", "WBGene00000778", "Q09936", "WBGene00016898", "Q23050", "WBGene00020808", "Q9N3B0", "WBGene00021888", "P0DM41", "WBGene00000063", "P0DM42", "WBGene00000065", "P10984", "WBGene00000064", "P10986", "WBGene00000066" ] }, "reaction_10509664": { "compartment": "compartment_70101", "id": "reaction_10509664", "reactome": "R-CEL-114689", "name": "PLC gamma 2-mediated PIP2 hydrolysis", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179856" ], "products": [ "species_114520", "species_114519" ], "modifiers": [ [ "species_10509661", "catalyst" ] ], "additional_components": [ "WBGene00004038" ] }, "reaction_10524321": { "compartment": "compartment_70101", "id": "reaction_10524321", "reactome": "R-CEL-442314", "name": "VAV3 is a GEF for Rho/Rac family kinases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10524313" ], "products": [ "species_29420", "species_10524315" ], "modifiers": [ [ "species_10524318", "catalyst" ] ], "additional_components": [ "Q22038", "WBGene00004357", "Q03206", "ced-10", "species_29420", "Q22038", "WBGene00004357", "Q03206", "ced-10", "species_29438", "WBGene00006887" ] }, "reaction_10523412": { "compartment": "compartment_876", "id": "reaction_10523412", "reactome": "R-CEL-429497", "name": "SLP-76 stimulates PLC gamma 2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10523410" ], "products": [ "species_10509661" ], "modifiers": [], "additional_components": [ "WBGene00004038", "WBGene00004038" ] }, "reaction_10524309": { "compartment": "compartment_70101", "id": "reaction_10524309", "reactome": "R-CEL-442291", "name": "VAV2 is a GEF for Rho/Rac family kinases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10524301" ], "products": [ "species_10524303", "species_29420" ], "modifiers": [ [ "species_10524306", "catalyst" ] ], "additional_components": [ "Q22038", "WBGene00004357", "species_29420", "Q22038", "WBGene00004357", "species_29438", "WBGene00006887" ] }, "reaction_10524295": { "compartment": "compartment_70101", "id": "reaction_10524295", "reactome": "R-CEL-442273", "name": "VAV1 is a GEF for Rho/Rac family GTPases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10524283" ], "products": [ "species_10524285", "species_29420" ], "modifiers": [ [ "species_10524288", "catalyst" ], [ "species_10524293", "catalyst" ], [ "species_10524291", "inhibitor" ] ], "additional_components": [ "Q94124", "WBGene00004287", "Q9BL44", "WBGene00022177", "Q03206", "ced-10", "species_29420", "Q94124", "WBGene00004287", "Q9BL44", "WBGene00022177", "Q03206", "ced-10", "species_29438", "WBGene00006887", "Q45FX5", "WBGene00006887", "species_179838", "species_179856", "Q45FX5", "WBGene00006887" ] }, "reaction_10524234": { "compartment": "compartment_70101", "id": "reaction_10524234", "reactome": "R-CEL-437162", "name": "PI3K alpha, beta, gamma convert PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10506892", "catalyst" ] ], "additional_components": [ "G5EDP9", "WBGene00000001", "Q94125", "WBGene00000090" ] }, "reaction_10521714": { "compartment": "compartment_70101", "id": "reaction_10521714", "reactome": "R-CEL-418091", "name": "F2R binds ARRB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10521710", "species_10521705" ], "products": [ "species_10521712" ], "modifiers": [], "additional_components": [ "WBGene00000195", "WBGene00016570", "H2KZ99", "WBGene00016570", "P51485", "WBGene00000195" ] }, "reaction_10509539": { "compartment": "compartment_70101", "id": "reaction_10509539", "reactome": "R-CEL-114552", "name": "Thrombin-activated PARs activate G12/13", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10509526" ], "products": [ "species_29420", "species_10509536" ], "modifiers": [ [ "species_10509512", "catalyst" ] ], "additional_components": [ "species_29420", "Q19572", "WBGene00001674", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "H2KZ99", "WBGene00016570", "H2KZ99", "WBGene00016570", "Q19572", "WBGene00001674", "species_29438", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "WBGene00016570" ] }, "reaction_10521731": { "compartment": "compartment_70101", "id": "reaction_10521731", "reactome": "R-CEL-418172", "name": "F2R binds ARRB2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10521727", "species_10521705" ], "products": [ "species_10521729" ], "modifiers": [], "additional_components": [ "WBGene00000195", "WBGene00016570", "H2KZ99", "WBGene00016570", "P51485", "WBGene00000195" ] }, "reaction_10521092": { "compartment": "compartment_876", "id": "reaction_10521092", "reactome": "R-CEL-396996", "name": "Thrombin-activated PARs binds G-protein Gq", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509512", "species_10509559" ], "products": [ "species_10509561" ], "modifiers": [], "additional_components": [ "WBGene00016570", "species_29420", "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "species_29420", "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "H2KZ99", "WBGene00016570" ] }, "reaction_10521094": { "compartment": "compartment_876", "id": "reaction_10521094", "reactome": "R-CEL-397835", "name": "Thrombin-activated PARs:Gq (active) dissociate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509563" ], "products": [ "species_10509165", "species_10508937", "species_10509512" ], "modifiers": [], "additional_components": [ "H2KZ99", "WBGene00016570", "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196", "species_29438", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196", "species_29438", "WBGene00016570" ] }, "reaction_10521718": { "compartment": "compartment_70101", "id": "reaction_10521718", "reactome": "R-CEL-418158", "name": "SRC-1 is activated (in F2R:ARRB1:MAPKs:SRC-1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10521716" ], "products": [ "species_10521716" ], "modifiers": [], "additional_components": [ "H2KZ99", "WBGene00016570", "P51485", "WBGene00000195", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "P39745", "WBGene00003401", "H2KZ99", "WBGene00016570", "P51485", "WBGene00000195", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "P39745", "WBGene00003401" ] }, "reaction_10521735": { "compartment": "compartment_70101", "id": "reaction_10521735", "reactome": "R-CEL-418176", "name": "F2R:ARRB2 binds MAPKs, SRC-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508575", "species_10513079", "species_10521729" ], "products": [ "species_10521733" ], "modifiers": [], "additional_components": [ "WBGene00003401", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "H2KZ99", "WBGene00016570", "P51485", "WBGene00000195", "H2KZ99", "WBGene00016570", "P51485", "WBGene00000195", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "P39745", "WBGene00003401" ] }, "reaction_10521737": { "compartment": "compartment_70101", "id": "reaction_10521737", "reactome": "R-CEL-418200", "name": "SRC-1 bound to ARRB2 is not activated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10521733" ], "products": [ "species_10521733" ], "modifiers": [], "additional_components": [ "H2KZ99", "WBGene00016570", "P51485", "WBGene00000195", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "P39745", "WBGene00003401", "H2KZ99", "WBGene00016570", "P51485", "WBGene00000195", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "P39745", "WBGene00003401" ] }, "reaction_10521098": { "compartment": "compartment_876", "id": "reaction_10521098", "reactome": "R-CEL-397891", "name": "Thrombin-activated PARs:G12/13 (active) dissociate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509536" ], "products": [ "species_10509165", "species_10509512", "species_10521096" ], "modifiers": [], "additional_components": [ "H2KZ99", "WBGene00016570", "Q19572", "WBGene00001674", "species_29438", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "WBGene00016570", "Q19572", "WBGene00001674", "species_29438" ] }, "reaction_10521723": { "compartment": "compartment_70101", "id": "reaction_10521723", "reactome": "R-CEL-418163", "name": "Activated SRC-1 activates MAPKs (in F2R:ARRB1:MAPKs:active SRC-1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10521716" ], "products": [ "species_10521720" ], "modifiers": [ [ "species_10521716", "catalyst" ] ], "additional_components": [ "H2KZ99", "WBGene00016570", "P51485", "WBGene00000195", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "P39745", "WBGene00003401", "H2KZ99", "WBGene00016570", "P51485", "WBGene00000195", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "P39745", "WBGene00003401", "H2KZ99", "WBGene00016570", "P51485", "WBGene00000195", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "P39745", "WBGene00003401" ] }, "reaction_10509565": { "compartment": "compartment_70101", "id": "reaction_10509565", "reactome": "R-CEL-114558", "name": "Thrombin-activated PARs activate Gq", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10509561" ], "products": [ "species_29420", "species_10509563" ], "modifiers": [ [ "species_10509512", "catalyst" ] ], "additional_components": [ "species_29420", "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "H2KZ99", "WBGene00016570", "H2KZ99", "WBGene00016570", "G5EGU1", "WBGene00001196", "Q9N4F4", "WBGene00022196", "species_29438", "P17343", "WBGene00001679", "P54406", "WBGene00001681", "WBGene00016570" ] }, "reaction_10521725": { "compartment": "compartment_70101", "id": "reaction_10521725", "reactome": "R-CEL-418170", "name": "F2R:ARRB1 binds MAPKs, SRC-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508575", "species_10513079", "species_10521712" ], "products": [ "species_10521716" ], "modifiers": [], "additional_components": [ "WBGene00003401", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "H2KZ99", "WBGene00016570", "P51485", "WBGene00000195", "H2KZ99", "WBGene00016570", "P51485", "WBGene00000195", "G5EE56", "WBGene00005077", "Q9N3S5", "WBGene00021635", "P39745", "WBGene00003401" ] }, "reaction_10528130": { "compartment": "compartment_70101", "id": "reaction_10528130", "reactome": "R-CEL-879459", "name": "F-actin capping protein is a heterodimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10528126", "species_10528121" ], "products": [ "species_10528128" ], "modifiers": [], "additional_components": [ "WBGene00000293", "WBGene00000292", "P34685", "WBGene00000292", "P34686", "WBGene00000293" ] }, "reaction_10531587": { "compartment": "compartment_70101", "id": "reaction_10531587", "reactome": "R-CEL-984606", "name": "Kinesin-5 is a homotetramer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10531494" ], "products": [ "species_10531496" ], "modifiers": [], "additional_components": [ "WBGene00000257", "G5ECF4", "WBGene00000257" ] }, "reaction_10531589": { "compartment": "compartment_70101", "id": "reaction_10531589", "reactome": "R-CEL-984648", "name": "Kinesin-6 and RACGAP1 form the heterotetrameric complex centralspindlin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10531503", "species_10531498" ], "products": [ "species_10531505" ], "modifiers": [], "additional_components": [ "WBGene00000875", "WBGene00006974", "Q8MQ03", "WBGene00006974", "Q9XUS9", "WBGene00000875" ] }, "reaction_10531464": { "compartment": "compartment_70101", "id": "reaction_10531464", "reactome": "R-CEL-983194", "name": "Kinesin-1 is a heterotetramer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10531453", "species_10531458" ], "products": [ "species_10531462" ], "modifiers": [], "additional_components": [ "P46822", "WBGene00002215", "H9G2T2", "WBGene00002214", "WBGene00006840", "P34540", "WBGene00006840", "P46822", "WBGene00002215", "H9G2T2", "WBGene00002214" ] }, "reaction_10531593": { "compartment": "compartment_70101", "id": "reaction_10531593", "reactome": "R-CEL-984733", "name": "Kinesin-3 is a dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10531591" ], "products": [ "species_10531489" ], "modifiers": [], "additional_components": [ "Q965T6", "WBGene00002230", "Q965T6", "WBGene00002230" ] }, "reaction_10531595": { "compartment": "compartment_70101", "id": "reaction_10531595", "reactome": "R-CEL-990489", "name": "Kinesin-13 is a dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10531521" ], "products": [ "species_10531529" ], "modifiers": [], "additional_components": [ "WBGene00002219", "Q9XU12", "WBGene00002219" ] }, "reaction_10531636": { "compartment": "compartment_7660", "id": "reaction_10531636", "reactome": "R-CEL-994106", "name": "HP1 alpha binds Histone H3K9(me)3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10531624", "species_10531632" ], "products": [ "species_10531634" ], "modifiers": [], "additional_components": [ "WBGene00000414", "K7ZUH9", "WBGene00001914", "Q10453", "WBGene00001945", "K7ZUH9", "WBGene00001914", "Q10453", "WBGene00001945", "P34618", "WBGene00000414" ] }, "reaction_10566148": { "compartment": "compartment_70101", "id": "reaction_10566148", "reactome": "R-CEL-8865107", "name": "MICAL1 produces NADP+, H2O2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_29364" ], "products": [ "species_29366", "species_29408" ], "modifiers": [ [ "species_10566145", "catalyst" ] ], "additional_components": [ "species_113596", "A0A061AD47", "WBGene00013289" ] }, "reaction_10531622": { "compartment": "compartment_70101", "id": "reaction_10531622", "reactome": "R-CEL-992708", "name": "Dual-specific AKAPs bind type I and II PKA regulatory subunits", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508956", "species_10531618" ], "products": [ "species_10531620" ], "modifiers": [], "additional_components": [ "P30625", "WBGene00002190", "P21137", "WBGene00002189", "Q10955", "WBGene00004348", "Q09285", "WBGene00016977", "Q10955", "WBGene00004348", "Q09285", "WBGene00016977", "P30625", "WBGene00002190", "P21137", "WBGene00002189" ] }, "reaction_10531606": { "compartment": "compartment_17906", "id": "reaction_10531606", "reactome": "R-CEL-992703", "name": "Mitofusins trans-interact linking mitochondria prior to fusion", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10531600" ], "products": [ "species_10531604" ], "modifiers": [], "additional_components": [ "WBGene00001509", "Q23424", "WBGene00001509" ] }, "reaction_10531750": { "compartment": "compartment_74700", "id": "reaction_10531750", "reactome": "R-CEL-1011600", "name": "Rabenosyn-5 connects Rab5 to VPS-45", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10531741", "species_10531705", "species_10531746" ], "products": [ "species_10531748" ], "modifiers": [], "additional_components": [ "WBGene00004268", "WBGene00021538", "WBGene00016643", "H2KYN0", "WBGene00016643", "W6SBE5", "WBGene00021538", "P91857", "WBGene00004268" ] }, "reaction_10531739": { "compartment": "compartment_70101", "id": "reaction_10531739", "reactome": "R-CEL-1011598", "name": "DOCKs bind to RhoGEFs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10531735", "species_10531733" ], "products": [ "species_10531737" ], "modifiers": [], "additional_components": [ "Q05062", "WBGene00000390", "Q03206", "ced-10", "A0A0K3AR51", "F22G12.5c", "Q20487", "WBGene00018520", "G5EEN3", "WBGene00000419", "A0A0K3AR51", "F22G12.5c", "Q20487", "WBGene00018520", "G5EEN3", "WBGene00000419", "Q05062", "WBGene00000390", "Q03206", "ced-10" ] }, "reaction_10531645": { "compartment": "compartment_70101", "id": "reaction_10531645", "reactome": "R-CEL-994148", "name": "LRRC16A binds F-actin capping protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10531641", "species_10528128" ], "products": [ "species_10531643" ], "modifiers": [], "additional_components": [ "WBGene00010641", "P34685", "WBGene00000292", "P34686", "WBGene00000293", "P34685", "WBGene00000292", "P34686", "WBGene00000293", "Q21301", "WBGene00010641" ] }, "reaction_10531709": { "compartment": "compartment_74700", "id": "reaction_10531709", "reactome": "R-CEL-1011576", "name": "EHD proteins interact with Rabenosyn-5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10531705", "species_10531696" ], "products": [ "species_10531707" ], "modifiers": [], "additional_components": [ "WBGene00021538", "WBGene00004373", "G5ECC3", "WBGene00004373", "W6SBE5", "WBGene00021538" ] }, "reaction_10532193": { "compartment": "compartment_70101", "id": "reaction_10532193", "reactome": "R-CEL-1234163", "name": "Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10532190", "species_10532188" ], "products": [ "species_10532186", "species_10532164" ], "modifiers": [ [ "species_10532190", "catalyst" ] ], "additional_components": [ "species_198836", "G5EBV0", "WBGene00001178", "species_113531", "G5ECR7", "WBGene00001235", "Q19213", "WBGene00006922", "Q9BKS1", "WBGene00001236", "Q23457", "WBGene00004320", "Q17390", "WBGene00000837", "G5EGD2", "WBGene00001851", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "P35129", "WBGene00002344", "P91853", "WBGene00006732", "Q17720", "WBGene00006717", "Q20617", "WBGene00006719", "P35129", "WBGene00002344", "P91853", "WBGene00006732", "Q17720", "WBGene00006717", "Q20617", "WBGene00006719", "species_198836", "G5EBV0", "WBGene00001178", "species_113531", "G5ECR7", "WBGene00001235", "Q19213", "WBGene00006922", "Q9BKS1", "WBGene00001236", "Q23457", "WBGene00004320", "Q17390", "WBGene00000837", "G5EGD2", "WBGene00001851", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "species_198836", "G5EBV0", "WBGene00001178", "species_113531", "G5ECR7", "WBGene00001235", "Q19213", "WBGene00006922", "Q9BKS1", "WBGene00001236", "Q23457", "WBGene00004320", "Q17390", "WBGene00000837", "G5EGD2", "WBGene00001851" ] }, "reaction_10532259": { "compartment": "compartment_7660", "id": "reaction_10532259", "reactome": "R-CEL-1234172", "name": "Nuclear VBC complex ubiquitinylates HIF-alpha", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10532252", "species_10532246" ], "products": [ "species_10511544", "species_10532256" ], "modifiers": [ [ "species_10532246", "catalyst" ] ], "additional_components": [ "P35129", "WBGene00002344", "P91853", "WBGene00006732", "Q17720", "WBGene00006717", "Q20617", "WBGene00006719", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "Q9BKS1", "WBGene00001236", "G5ECR7", "WBGene00001235", "Q19213", "WBGene00006922", "Q23457", "WBGene00004320", "Q17390", "WBGene00000837", "G5EGD2", "WBGene00001851", "P35129", "WBGene00002344", "P91853", "WBGene00006732", "Q17720", "WBGene00006717", "Q20617", "WBGene00006719", "Q9BKS1", "WBGene00001236", "G5ECR7", "WBGene00001235", "Q19213", "WBGene00006922", "Q23457", "WBGene00004320", "Q17390", "WBGene00000837", "G5EGD2", "WBGene00001851", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "Q9BKS1", "WBGene00001236", "G5ECR7", "WBGene00001235", "Q19213", "WBGene00006922", "Q23457", "WBGene00004320", "Q17390", "WBGene00000837", "G5EGD2", "WBGene00001851" ] }, "reaction_10532262": { "compartment": "compartment_70101", "id": "reaction_10532262", "reactome": "R-CEL-1234173", "name": "Cytosolic PHD2,3 hydroxylates proline residues on HIF3A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29406", "species_29368", "species_10532176" ], "products": [ "species_10532141", "species_29434", "species_113528" ], "modifiers": [ [ "species_10532162", "catalyst" ] ], "additional_components": [ "WBGene00001851", "WBGene00001851", "species_198836", "G5EBV0", "WBGene00001178", "species_113531", "G5ECR7", "WBGene00001235", "Q19213", "WBGene00006922", "Q9BKS1", "WBGene00001236", "Q23457", "WBGene00004320", "Q17390", "WBGene00000837" ] }, "reaction_10532214": { "compartment": "compartment_7660", "id": "reaction_10532214", "reactome": "R-CEL-1234165", "name": "Nuclear PHD1,3 hydroxylates proline residues on HIF3A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10532182", "species_113671", "species_113685" ], "products": [ "species_10532201", "species_159942", "species_159939" ], "modifiers": [ [ "species_10532211", "catalyst" ] ], "additional_components": [ "WBGene00001851", "WBGene00001851", "species_113531", "species_198836", "G5EBV0", "WBGene00001178" ] }, "reaction_10532248": { "compartment": "compartment_7660", "id": "reaction_10532248", "reactome": "R-CEL-1234169", "name": "Nuclear VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10532234", "species_10532244" ], "products": [ "species_10532246" ], "modifiers": [], "additional_components": [ "WBGene00001851", "Q9BKS1", "WBGene00001236", "G5ECR7", "WBGene00001235", "Q19213", "WBGene00006922", "Q23457", "WBGene00004320", "Q17390", "WBGene00000837", "Q9BKS1", "WBGene00001236", "G5ECR7", "WBGene00001235", "Q19213", "WBGene00006922", "Q23457", "WBGene00004320", "Q17390", "WBGene00000837", "G5EGD2", "WBGene00001851" ] }, "reaction_10532264": { "compartment": "compartment_70101", "id": "reaction_10532264", "reactome": "R-CEL-1234175", "name": "ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10532256" ], "products": [ "species_10532145" ], "modifiers": [], "additional_components": [ "Q9BKS1", "WBGene00001236", "G5ECR7", "WBGene00001235", "Q19213", "WBGene00006922", "Q23457", "WBGene00004320", "Q17390", "WBGene00000837", "G5EGD2", "WBGene00001851", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "G5ECR7", "WBGene00001235", "Q19213", "WBGene00006922", "Q9BKS1", "WBGene00001236", "Q23457", "WBGene00004320", "Q17390", "WBGene00000837", "G5EGD2", "WBGene00001851", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727" ] }, "reaction_10532266": { "compartment": "compartment_70101", "id": "reaction_10532266", "reactome": "R-CEL-1234177", "name": "Cytosolic PHD2,3 hydroxylates proline residues on HIF1A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29406", "species_10532174", "species_29368" ], "products": [ "species_29434", "species_10532138", "species_113528" ], "modifiers": [ [ "species_10532162", "catalyst" ] ], "additional_components": [ "WBGene00001851", "WBGene00001851", "species_198836", "G5EBV0", "WBGene00001178", "species_113531", "G5ECR7", "WBGene00001235", "Q19213", "WBGene00006922", "Q9BKS1", "WBGene00001236", "Q23457", "WBGene00004320", "Q17390", "WBGene00000837" ] }, "reaction_10532170": { "compartment": "compartment_70101", "id": "reaction_10532170", "reactome": "R-CEL-1234159", "name": "Proteasome proteolyzes ub-HIF-alpha", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10532166" ], "products": [ "species_10532168", "species_10502375" ], "modifiers": [ [ "species_10502572", "catalyst" ] ], "additional_components": [ "G5ECR7", "WBGene00001235", "Q19213", "WBGene00006922", "Q9BKS1", "WBGene00001236", "Q23457", "WBGene00004320", "Q17390", "WBGene00000837", "G5EGD2", "WBGene00001851", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "species_198836", "G5EBV0", "WBGene00001178", "species_113531", "species_198836", "G5EBV0", "WBGene00001178", "species_113531", "G5ECR7", "WBGene00001235", "Q19213", "WBGene00006922", "Q9BKS1", "WBGene00001236", "Q23457", "WBGene00004320", "Q17390", "WBGene00000837", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "P91477", "WBGene00003950", "Q95PZ7", "WBGene00013435", "Q18115", "WBGene00004459", "O62102", "WBGene00003948", "O17071", "WBGene00004504", "Q10920", "WBGene00016623", "P34286", "WBGene00003952", "Q9XTT9", "WBGene00004506", "Q23449", "WBGene00004468", "Q95005", "WBGene00003925", "P46502", "WBGene00004503", "O61792", "WBGene00004464", "O17586", "WBGene00003922", "O76371", "WBGene00004505", "Q20585", "WBGene00004463", "Q95008", "WBGene00003926", "Q18787", "WBGene00004501", "Q20058", "WBGene00009445", "Q9N599", "WBGene00003924", "O16368", "WBGene00004502", "O61742", "WBGene00004466", "Q09583", "WBGene00003928", "Q966I8", "WBGene00003947", "Q04908", "WBGene00004460", "Q9XUV0", "WBGene00003951", "Q27488", "WBGene00003923", "Q9GZH5", "WBGene00004458", "O44156", "WBGene00003927", "Q22253", "WBGene00004465", "O76577", "WBGene00004467", "P90868", "WBGene00003953", "Q19324", "WBGene00004461", "Q17971", "WBGene00007588", "Q23237", "WBGene00003949", "Q20938", "WBGene00004462" ] }, "reaction_10532268": { "compartment": "compartment_7660", "id": "reaction_10532268", "reactome": "R-CEL-1234181", "name": "Nuclear PHD1,3 hydroxylates proline residues on HIF1A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113671", "species_113685", "species_10532180" ], "products": [ "species_10532236", "species_159942", "species_159939" ], "modifiers": [ [ "species_10532211", "catalyst" ] ], "additional_components": [ "WBGene00001851", "WBGene00001851", "species_113531", "species_198836", "G5EBV0", "WBGene00001178" ] }, "reaction_10532270": { "compartment": "compartment_70101", "id": "reaction_10532270", "reactome": "R-CEL-1234183", "name": "Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10532134", "species_10532162" ], "products": [ "species_10532190" ], "modifiers": [], "additional_components": [ "WBGene00001851", "species_198836", "G5EBV0", "WBGene00001178", "species_113531", "G5ECR7", "WBGene00001235", "Q19213", "WBGene00006922", "Q9BKS1", "WBGene00001236", "Q23457", "WBGene00004320", "Q17390", "WBGene00000837", "species_198836", "G5EBV0", "WBGene00001178", "species_113531", "G5ECR7", "WBGene00001235", "Q19213", "WBGene00006922", "Q9BKS1", "WBGene00001236", "Q23457", "WBGene00004320", "Q17390", "WBGene00000837", "G5EGD2", "WBGene00001851" ] }, "reaction_10521058": { "compartment": "compartment_70101", "id": "reaction_10521058", "reactome": "R-CEL-392513", "name": "Rap1 signal termination by Rap1GAPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10518164" ], "products": [ "species_111294", "species_10518265" ], "modifiers": [ [ "species_10521051", "catalyst" ], [ "species_10521056", "inhibitor" ] ], "additional_components": [ "Q18246", "WBGene00004307", "species_29438", "Q18246", "WBGene00004307", "species_29420", "H2L2C2", "WBGene00012100", "H2L055", "WBGene00018734", "H2L055", "WBGene00018734", "Q20655", "WBGene00001502", "P41932", "WBGene00003920" ] }, "reaction_10521090": { "compartment": "compartment_70101", "id": "reaction_10521090", "reactome": "R-CEL-392835", "name": "Rap1 sequesters Raf1 to inhibit ERK cascade", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10521086", "species_10518164" ], "products": [ "species_10521088" ], "modifiers": [], "additional_components": [ "WBGene00003030", "Q18246", "WBGene00004307", "species_29438", "Q18246", "WBGene00004307", "species_29438", "Q07292", "WBGene00003030" ] }, "reaction_10528644": { "compartment": "compartment_70101", "id": "reaction_10528644", "reactome": "R-CEL-913993", "name": "14-3-3 proteins beta and zeta bind and inhibit Rap1Gap2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10521054", "species_10521049" ], "products": [ "species_10521056" ], "modifiers": [ [ "species_10528642", "inhibitor" ] ], "additional_components": [ "Q20655", "WBGene00001502", "P41932", "WBGene00003920", "WBGene00018734", "H2L055", "WBGene00018734", "Q20655", "WBGene00001502", "P41932", "WBGene00003920", "WBGene00018734" ] }, "reaction_10521081": { "compartment": "compartment_70101", "id": "reaction_10521081", "reactome": "R-CEL-392834", "name": "Activation of EPACs by cAMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10520078", "species_30389" ], "products": [ "species_10520080" ], "modifiers": [], "additional_components": [ "WBGene00004255", "species_30389", "P34578", "WBGene00004255" ] }, "reaction_10528655": { "compartment": "compartment_70101", "id": "reaction_10528655", "reactome": "R-CEL-913996", "name": "PKA/PKG phosphorylate Rap1GAP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10521049" ], "products": [ "species_29370", "species_10528642" ], "modifiers": [ [ "species_10528652", "catalyst" ] ], "additional_components": [ "WBGene00018734", "WBGene00018734", "O76360", "WBGene00001173", "P21137", "WBGene00002189" ] }, "reaction_10531425": { "compartment": "compartment_70101", "id": "reaction_10531425", "reactome": "R-CEL-983162", "name": "Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_983036" ], "products": [ "species_983032", "species_8942986" ], "modifiers": [ [ "species_10531422", "catalyst" ] ], "additional_components": [ "Q4TT88", "WBGene00003914", "Q9NAA0", "WBGene00022073", "A5A631", "WBGene00022073", "G5EGH4", "WBGene00022073", "H2L0M5", "WBGene00022073", "Q22317", "WBGene00011587", "Q09541", "WBGene00017686" ] }, "reaction_10531346": { "compartment": "compartment_70101", "id": "reaction_10531346", "reactome": "R-CEL-983156", "name": "Polyubiquitination of substrate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10531247", "species_113592", "species_10531253" ], "products": [ "species_111294", "species_10531245", "species_76577", "species_10531312" ], "modifiers": [ [ "species_10531253", "catalyst" ] ], "additional_components": [ "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "P52478", "WBGene00006701", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "O62235", "WBGene00009477", "Q965X6", "WBGene00021369", "Q9N3T6", "WBGene00021640", "Q9N4I6", "WBGene00022115", "Q94251", "WBGene00001089", "Q17531", "WBGene00007206", "Q17962", "WBGene00007574", "O17324", "WBGene00015673", "Q20367", "WBGene00005013", "Q9GYI0", "WBGene00017920", "O45323", "WBGene00008439", "P34284", "WBGene00015350", "Q6A590", "WBGene00020884", "G5EES6", "WBGene00007333", "Q9N3G1", "WBGene00021815", "Q22071", "WBGene00003177", "G5ECU1", "WBGene00004807", "Q17389", "WBGene00000836", "Q23457", "WBGene00004320", "Q965N7", "WBGene00021596", "Q965N6", "WBGene00021597", "L8E6Y3", "WBGene00016407", "P91133", "WBGene00016326", "Q9BL11", "WBGene00021685", "U4PBY0", "WBGene00022069", "B1Q249", "WBGene00015926", "Q9UAQ3", "WBGene00016539", "A0A061ACQ8", "WBGene00022358", "Q20871", "WBGene00021721", "Q20874", "WBGene00021721", "A8DJA6", "WBGene00021721", "P52478", "WBGene00006701", "O62235", "WBGene00009477", "Q965X6", "WBGene00021369", "Q9N3T6", "WBGene00021640", "Q9N4I6", "WBGene00022115", "Q94251", "WBGene00001089", "Q17531", "WBGene00007206", "Q17962", "WBGene00007574", "O17324", "WBGene00015673", "Q20367", "WBGene00005013", "Q9GYI0", "WBGene00017920", "O45323", "WBGene00008439", "P34284", "WBGene00015350", "Q6A590", "WBGene00020884", "G5EES6", "WBGene00007333", "Q9N3G1", "WBGene00021815", "Q22071", "WBGene00003177", "G5ECU1", "WBGene00004807", "Q17389", "WBGene00000836", "Q23457", "WBGene00004320", "Q965N7", "WBGene00021596", "Q965N6", "WBGene00021597", "L8E6Y3", "WBGene00016407", "P91133", "WBGene00016326", "Q9BL11", "WBGene00021685", "U4PBY0", "WBGene00022069", "B1Q249", "WBGene00015926", "Q9UAQ3", "WBGene00016539", "A0A061ACQ8", "WBGene00022358", "Q20871", "WBGene00021721", "Q20874", "WBGene00021721", "A8DJA6", "WBGene00021721", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "O62235", "WBGene00009477", "Q965X6", "WBGene00021369", "Q9N3T6", "WBGene00021640", "Q9N4I6", "WBGene00022115", "Q94251", "WBGene00001089", "Q17531", "WBGene00007206", "Q17962", "WBGene00007574", "O17324", "WBGene00015673", "Q20367", "WBGene00005013", "Q9GYI0", "WBGene00017920", "O45323", "WBGene00008439", "P34284", "WBGene00015350", "Q6A590", "WBGene00020884", "G5EES6", "WBGene00007333", "Q9N3G1", "WBGene00021815", "Q22071", "WBGene00003177", "G5ECU1", "WBGene00004807", "Q17389", "WBGene00000836", "Q23457", "WBGene00004320", "Q965N7", "WBGene00021596", "Q965N6", "WBGene00021597", "L8E6Y3", "WBGene00016407", "P91133", "WBGene00016326", "Q9BL11", "WBGene00021685", "U4PBY0", "WBGene00022069", "B1Q249", "WBGene00015926", "Q9UAQ3", "WBGene00016539", "A0A061ACQ8", "WBGene00022358", "Q20871", "WBGene00021721", "Q20874", "WBGene00021721", "A8DJA6", "WBGene00021721" ] }, "reaction_10531314": { "compartment": "compartment_70101", "id": "reaction_10531314", "reactome": "R-CEL-983147", "name": "Release of E3 from polyubiquitinated substrate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10531312" ], "products": [ "species_983123", "species_10531179" ], "modifiers": [], "additional_components": [ "O62235", "WBGene00009477", "Q965X6", "WBGene00021369", "Q9N3T6", "WBGene00021640", "Q9N4I6", "WBGene00022115", "Q94251", "WBGene00001089", "Q17531", "WBGene00007206", "Q17962", "WBGene00007574", "O17324", "WBGene00015673", "Q20367", "WBGene00005013", "Q9GYI0", "WBGene00017920", "O45323", "WBGene00008439", "P34284", "WBGene00015350", "Q6A590", "WBGene00020884", "G5EES6", "WBGene00007333", "Q9N3G1", "WBGene00021815", "Q22071", "WBGene00003177", "G5ECU1", "WBGene00004807", "Q17389", "WBGene00000836", "Q23457", "WBGene00004320", "Q965N7", "WBGene00021596", "Q965N6", "WBGene00021597", "L8E6Y3", "WBGene00016407", "P91133", "WBGene00016326", "Q9BL11", "WBGene00021685", "U4PBY0", "WBGene00022069", "B1Q249", "WBGene00015926", "Q9UAQ3", "WBGene00016539", "A0A061ACQ8", "WBGene00022358", "Q20871", "WBGene00021721", "Q20874", "WBGene00021721", "A8DJA6", "WBGene00021721", "O62235", "WBGene00009477", "Q965X6", "WBGene00021369", "Q9N3T6", "WBGene00021640", "Q9N4I6", "WBGene00022115", "Q94251", "WBGene00001089", "Q17531", "WBGene00007206", "Q17962", "WBGene00007574", "O17324", "WBGene00015673", "Q20367", "WBGene00005013", "Q9GYI0", "WBGene00017920", "O45323", "WBGene00008439", "P34284", "WBGene00015350", "Q6A590", "WBGene00020884", "G5EES6", "WBGene00007333", "Q9N3G1", "WBGene00021815", "Q22071", "WBGene00003177", "G5ECU1", "WBGene00004807", "Q17389", "WBGene00000836", "Q23457", "WBGene00004320", "Q965N7", "WBGene00021596", "Q965N6", "WBGene00021597", "L8E6Y3", "WBGene00016407", "P91133", "WBGene00016326", "Q9BL11", "WBGene00021685", "U4PBY0", "WBGene00022069", "B1Q249", "WBGene00015926", "Q9UAQ3", "WBGene00016539", "A0A061ACQ8", "WBGene00022358", "Q20871", "WBGene00021721", "Q20874", "WBGene00021721", "A8DJA6", "WBGene00021721" ] }, "reaction_10531348": { "compartment": "compartment_70101", "id": "reaction_10531348", "reactome": "R-CEL-983157", "name": "Interaction of E3 with substrate and E2-Ub complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10531247", "species_10531179", "species_983035" ], "products": [ "species_10531249" ], "modifiers": [], "additional_components": [ "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "P52478", "WBGene00006701", "O62235", "WBGene00009477", "Q965X6", "WBGene00021369", "Q9N3T6", "WBGene00021640", "Q9N4I6", "WBGene00022115", "Q94251", "WBGene00001089", "Q17531", "WBGene00007206", "Q17962", "WBGene00007574", "O17324", "WBGene00015673", "Q20367", "WBGene00005013", "Q9GYI0", "WBGene00017920", "O45323", "WBGene00008439", "P34284", "WBGene00015350", "Q6A590", "WBGene00020884", "G5EES6", "WBGene00007333", "Q9N3G1", "WBGene00021815", "Q22071", "WBGene00003177", "G5ECU1", "WBGene00004807", "Q17389", "WBGene00000836", "Q23457", "WBGene00004320", "Q965N7", "WBGene00021596", "Q965N6", "WBGene00021597", "L8E6Y3", "WBGene00016407", "P91133", "WBGene00016326", "Q9BL11", "WBGene00021685", "U4PBY0", "WBGene00022069", "B1Q249", "WBGene00015926", "Q9UAQ3", "WBGene00016539", "A0A061ACQ8", "WBGene00022358", "Q20871", "WBGene00021721", "Q20874", "WBGene00021721", "A8DJA6", "WBGene00021721", "O62235", "WBGene00009477", "Q965X6", "WBGene00021369", "Q9N3T6", "WBGene00021640", "Q9N4I6", "WBGene00022115", "Q94251", "WBGene00001089", "Q17531", "WBGene00007206", "Q17962", "WBGene00007574", "O17324", "WBGene00015673", "Q20367", "WBGene00005013", "Q9GYI0", "WBGene00017920", "O45323", "WBGene00008439", "P34284", "WBGene00015350", "Q6A590", "WBGene00020884", "G5EES6", "WBGene00007333", "Q9N3G1", "WBGene00021815", "Q22071", "WBGene00003177", "G5ECU1", "WBGene00004807", "Q17389", "WBGene00000836", "Q23457", "WBGene00004320", "Q965N7", "WBGene00021596", "Q965N6", "WBGene00021597", "L8E6Y3", "WBGene00016407", "P91133", "WBGene00016326", "Q9BL11", "WBGene00021685", "U4PBY0", "WBGene00022069", "B1Q249", "WBGene00015926", "Q9UAQ3", "WBGene00016539", "A0A061ACQ8", "WBGene00022358", "Q20871", "WBGene00021721", "Q20874", "WBGene00021721", "A8DJA6", "WBGene00021721", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "P52478", "WBGene00006701" ] }, "reaction_10531316": { "compartment": "compartment_70101", "id": "reaction_10531316", "reactome": "R-CEL-983150", "name": "Proteasomal cleavage of substrate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_983123" ], "products": [ "species_10502375", "species_983032", "species_8942986", "species_983036" ], "modifiers": [ [ "species_10502572", "catalyst" ] ], "additional_components": [ "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "P91477", "WBGene00003950", "Q95PZ7", "WBGene00013435", "Q18115", "WBGene00004459", "O62102", "WBGene00003948", "O17071", "WBGene00004504", "Q10920", "WBGene00016623", "P34286", "WBGene00003952", "Q9XTT9", "WBGene00004506", "Q23449", "WBGene00004468", "Q95005", "WBGene00003925", "P46502", "WBGene00004503", "O61792", "WBGene00004464", "O17586", "WBGene00003922", "O76371", "WBGene00004505", "Q20585", "WBGene00004463", "Q95008", "WBGene00003926", "Q18787", "WBGene00004501", "Q20058", "WBGene00009445", "Q9N599", "WBGene00003924", "O16368", "WBGene00004502", "O61742", "WBGene00004466", "Q09583", "WBGene00003928", "Q966I8", "WBGene00003947", "Q04908", "WBGene00004460", "Q9XUV0", "WBGene00003951", "Q27488", "WBGene00003923", "Q9GZH5", "WBGene00004458", "O44156", "WBGene00003927", "Q22253", "WBGene00004465", "O76577", "WBGene00004467", "P90868", "WBGene00003953", "Q19324", "WBGene00004461", "Q17971", "WBGene00007588", "Q23237", "WBGene00003949", "Q20938", "WBGene00004462" ] }, "reaction_10531256": { "compartment": "compartment_70101", "id": "reaction_10531256", "reactome": "R-CEL-983140", "name": "Transfer of Ub from E2 to substrate and release of E2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10531249" ], "products": [ "species_111294", "species_10531245", "species_10531253", "species_76577" ], "modifiers": [ [ "species_10531179", "catalyst" ] ], "additional_components": [ "O62235", "WBGene00009477", "Q965X6", "WBGene00021369", "Q9N3T6", "WBGene00021640", "Q9N4I6", "WBGene00022115", "Q94251", "WBGene00001089", "Q17531", "WBGene00007206", "Q17962", "WBGene00007574", "O17324", "WBGene00015673", "Q20367", "WBGene00005013", "Q9GYI0", "WBGene00017920", "O45323", "WBGene00008439", "P34284", "WBGene00015350", "Q6A590", "WBGene00020884", "G5EES6", "WBGene00007333", "Q9N3G1", "WBGene00021815", "Q22071", "WBGene00003177", "G5ECU1", "WBGene00004807", "Q17389", "WBGene00000836", "Q23457", "WBGene00004320", "Q965N7", "WBGene00021596", "Q965N6", "WBGene00021597", "L8E6Y3", "WBGene00016407", "P91133", "WBGene00016326", "Q9BL11", "WBGene00021685", "U4PBY0", "WBGene00022069", "B1Q249", "WBGene00015926", "Q9UAQ3", "WBGene00016539", "A0A061ACQ8", "WBGene00022358", "Q20871", "WBGene00021721", "Q20874", "WBGene00021721", "A8DJA6", "WBGene00021721", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "P52478", "WBGene00006701", "P52478", "WBGene00006701", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "O62235", "WBGene00009477", "Q965X6", "WBGene00021369", "Q9N3T6", "WBGene00021640", "Q9N4I6", "WBGene00022115", "Q94251", "WBGene00001089", "Q17531", "WBGene00007206", "Q17962", "WBGene00007574", "O17324", "WBGene00015673", "Q20367", "WBGene00005013", "Q9GYI0", "WBGene00017920", "O45323", "WBGene00008439", "P34284", "WBGene00015350", "Q6A590", "WBGene00020884", "G5EES6", "WBGene00007333", "Q9N3G1", "WBGene00021815", "Q22071", "WBGene00003177", "G5ECU1", "WBGene00004807", "Q17389", "WBGene00000836", "Q23457", "WBGene00004320", "Q965N7", "WBGene00021596", "Q965N6", "WBGene00021597", "L8E6Y3", "WBGene00016407", "P91133", "WBGene00016326", "Q9BL11", "WBGene00021685", "U4PBY0", "WBGene00022069", "B1Q249", "WBGene00015926", "Q9UAQ3", "WBGene00016539", "A0A061ACQ8", "WBGene00022358", "Q20871", "WBGene00021721", "Q20874", "WBGene00021721", "A8DJA6", "WBGene00021721", "O62235", "WBGene00009477", "Q965X6", "WBGene00021369", "Q9N3T6", "WBGene00021640", "Q9N4I6", "WBGene00022115", "Q94251", "WBGene00001089", "Q17531", "WBGene00007206", "Q17962", "WBGene00007574", "O17324", "WBGene00015673", "Q20367", "WBGene00005013", "Q9GYI0", "WBGene00017920", "O45323", "WBGene00008439", "P34284", "WBGene00015350", "Q6A590", "WBGene00020884", "G5EES6", "WBGene00007333", "Q9N3G1", "WBGene00021815", "Q22071", "WBGene00003177", "G5ECU1", "WBGene00004807", "Q17389", "WBGene00000836", "Q23457", "WBGene00004320", "Q965N7", "WBGene00021596", "Q965N6", "WBGene00021597", "L8E6Y3", "WBGene00016407", "P91133", "WBGene00016326", "Q9BL11", "WBGene00021685", "U4PBY0", "WBGene00022069", "B1Q249", "WBGene00015926", "Q9UAQ3", "WBGene00016539", "A0A061ACQ8", "WBGene00022358", "Q20871", "WBGene00021721", "Q20874", "WBGene00021721", "A8DJA6", "WBGene00021721" ] }, "reaction_10531340": { "compartment": "compartment_70101", "id": "reaction_10531340", "reactome": "R-CEL-983152", "name": "Transfer of ubiquitin from E1 to E2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10531245", "species_10531337" ], "products": [ "species_10531247", "species_10531335" ], "modifiers": [ [ "species_10531245", "catalyst" ] ], "additional_components": [ "P52478", "WBGene00006701", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "P52478", "WBGene00006701", "P52478", "WBGene00006701" ] }, "reaction_10531343": { "compartment": "compartment_70101", "id": "reaction_10531343", "reactome": "R-CEL-983153", "name": "E1 mediated ubiquitin activation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10531335", "species_10502375", "species_29926" ], "products": [ "species_111294", "species_10531337", "species_29926", "species_76577" ], "modifiers": [ [ "species_10531335", "catalyst" ] ], "additional_components": [ "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727" ] }, "reaction_10531399": { "compartment": "compartment_17957", "id": "reaction_10531399", "reactome": "R-CEL-983158", "name": "Trimming of peptides in ER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_983034" ], "products": [ "species_8943716", "species_983033" ], "modifiers": [ [ "species_10531396", "catalyst" ] ], "additional_components": [ "Q9NAA0", "WBGene00022073", "A5A631", "WBGene00022073", "G5EGH4", "WBGene00022073", "H2L0M5", "WBGene00022073", "Q22317", "WBGene00011587", "Q4TT88", "WBGene00003914" ] }, "reaction_10531304": { "compartment": "compartment_17957", "id": "reaction_10531304", "reactome": "R-CEL-983144", "name": "Transport of Antigen peptide in to ER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_983032" ], "products": [ "species_29372", "species_29370", "species_983034" ], "modifiers": [ [ "species_10531301", "catalyst" ] ], "additional_components": [ "Q9U275", "WBGene00001817", "O02086", "WBGene00001812", "O18227", "WBGene00001818", "O44897", "WBGene00001819", "Q9TZD9", "WBGene00001814" ] }, "reaction_10515960": { "compartment": "compartment_12045", "id": "reaction_10515960", "reactome": "R-CEL-203979", "name": "Coat Assembly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10515678", "species_10515956" ], "products": [ "species_10515958" ], "modifiers": [], "additional_components": [ "Q23445", "WBGene00022678", "species_29438", "Q9U2Z1", "WBGene00004754", "Q19371", "WBGene00004755", "Q23368", "WBGene00004756", "Q23368", "WBGene00004756", "Q19371", "WBGene00004755", "Q9U2Z1", "WBGene00004754", "Q23445", "WBGene00022678", "species_29438" ] }, "reaction_10543540": { "compartment": "compartment_161320", "id": "reaction_10543540", "reactome": "R-CEL-2213240", "name": "Reduction of disulphide bonds in MHC II antigens", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2213221" ], "products": [ "species_2213225" ], "modifiers": [ [ "species_10543537", "catalyst" ] ], "additional_components": [ "WBGene00015336" ] }, "reaction_10542853": { "compartment": "compartment_161320", "id": "reaction_10542853", "reactome": "R-CEL-2130706", "name": "MHC class II antigen processing", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2213225" ], "products": [ "species_2213226" ], "modifiers": [ [ "species_10542850", "catalyst" ] ], "additional_components": [ "Q21966", "WBGene00000217", "Q93512", "WBGene00019986", "O45734", "WBGene00000776", "Q23030", "WBGene00019986", "O16454", "WBGene00007055" ] }, "reaction_10531914": { "compartment": "compartment_70101", "id": "reaction_10531914", "reactome": "R-CEL-1168373", "name": "PRKCB (Protein kinase C beta, PKC-beta) binds diacylglycerol and phosphatidylserine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_33625", "species_114519", "species_10509541", "species_74016" ], "products": [ "species_10509549" ], "modifiers": [], "additional_components": [ "WBGene00004033", "species_114519", "species_33625", "species_74016", "P90980", "WBGene00004033" ] }, "reaction_10531939": { "compartment": "compartment_876", "id": "reaction_10531939", "reactome": "R-CEL-1168636", "name": "p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10512175", "species_29438" ], "products": [ "species_29420", "species_10511481" ], "modifiers": [ [ "species_10531936", "catalyst" ] ], "additional_components": [ "species_29420", "P22981", "WBGene00002335", "species_29438", "P22981", "WBGene00002335", "species_114519", "Q19770", "WBGene00009100" ] }, "reaction_10520805": { "compartment": "compartment_70101", "id": "reaction_10520805", "reactome": "R-CEL-390329", "name": "Dephosphorylation of AKT by PP2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10513848" ], "products": [ "species_29372", "species_10520802" ], "modifiers": [ [ "species_10513555", "catalyst" ] ], "additional_components": [ "Q9XTG7", "WBGene00000103", "G4S4W1", "WBGene00016980", "Q17941", "WBGene00000102", "G4S4W1", "WBGene00016980", "Q17941", "WBGene00000102", "Q9XTG7", "WBGene00000103" ] }, "reaction_10537056": { "compartment": "compartment_876", "id": "reaction_10537056", "reactome": "R-CEL-1675773", "name": "PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_202247" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10537051", "catalyst" ] ], "additional_components": [ "WBGene00004087" ] }, "reaction_10537312": { "compartment": "compartment_876", "id": "reaction_10537312", "reactome": "R-CEL-1676164", "name": "PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_202247" ], "products": [ "species_1806276", "species_29372" ], "modifiers": [ [ "species_10537307", "catalyst" ] ], "additional_components": [ "Q21623", "WBGene00010975" ] }, "reaction_10537153": { "compartment": "compartment_876", "id": "reaction_10537153", "reactome": "R-CEL-1675836", "name": "PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1806224" ], "products": [ "species_1806276", "species_29372" ], "modifiers": [ [ "species_10537150", "catalyst" ] ], "additional_components": [ "O17590", "WBGene00007620", "G5ECL2", "WBGene00006763" ] }, "reaction_10537283": { "compartment": "compartment_876", "id": "reaction_10537283", "reactome": "R-CEL-1676134", "name": "PI3P is phosphorylated to PI(3,5)P2 by PIP5K1A/B at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806276", "species_113592" ], "products": [ "species_1806224", "species_29370" ], "modifiers": [ [ "species_10537051", "catalyst" ] ], "additional_components": [ "WBGene00004087" ] }, "reaction_10537317": { "compartment": "compartment_876", "id": "reaction_10537317", "reactome": "R-CEL-1676177", "name": "PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_179856" ], "products": [ "species_29372", "species_392417" ], "modifiers": [ [ "species_10537314", "catalyst" ] ], "additional_components": [ "G5ECL2", "WBGene00006763", "G5EGN9", "WBGene00012016", "P34370", "WBGene00086546" ] }, "reaction_10537126": { "compartment": "compartment_876", "id": "reaction_10537126", "reactome": "R-CEL-1675810", "name": "PI is phosphorylated to PI5P by PIP5K1A/B at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_426658" ], "products": [ "species_1806240", "species_29370" ], "modifiers": [ [ "species_10537051", "catalyst" ] ], "additional_components": [ "WBGene00004087" ] }, "reaction_10537222": { "compartment": "compartment_876", "id": "reaction_10537222", "reactome": "R-CEL-1675988", "name": "PI4P is dephosphorylated to PI by SYNJ at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_392417" ], "products": [ "species_29372", "species_426658" ], "modifiers": [ [ "species_10537150", "catalyst" ] ], "additional_components": [ "O17590", "WBGene00007620", "G5ECL2", "WBGene00006763" ] }, "reaction_10563656": { "compartment": "compartment_70101", "id": "reaction_10563656", "reactome": "R-CEL-6809309", "name": "MTMR6 binds MTMR9", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10563629", "species_10537228" ], "products": [ "species_10563654" ], "modifiers": [], "additional_components": [ "WBGene00003479", "F53A2.8a", "G5ED68", "F53A2.8a", "Q965W9", "WBGene00003479" ] }, "reaction_10537291": { "compartment": "compartment_876", "id": "reaction_10537291", "reactome": "R-CEL-1676145", "name": "PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806276", "species_113592" ], "products": [ "species_29370", "species_202247" ], "modifiers": [ [ "species_10537288", "catalyst" ] ], "additional_components": [ "Q9BL73", "WBGene00004088", "O01759", "WBGene00004087" ] }, "reaction_10563661": { "compartment": "compartment_876", "id": "reaction_10563661", "reactome": "R-CEL-6809320", "name": "PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1806224" ], "products": [ "species_29372", "species_1806240" ], "modifiers": [ [ "species_10563658", "catalyst" ] ], "additional_components": [ "G5ED68", "F53A2.8a", "Q965W9", "WBGene00003479" ] }, "reaction_10537325": { "compartment": "compartment_876", "id": "reaction_10537325", "reactome": "R-CEL-1676203", "name": "PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1806224" ], "products": [ "species_29372", "species_1806240" ], "modifiers": [ [ "species_10537230", "catalyst" ] ], "additional_components": [ "Q9N589", "WBGene00003475", "Q22712", "WBGene00003476", "G5ECL2", "WBGene00006763", "G5ED68", "F53A2.8a" ] }, "reaction_10537101": { "compartment": "compartment_876", "id": "reaction_10537101", "reactome": "R-CEL-1675780", "name": "PI is phosphorylated to PI4P by PI4K2A/B at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_426658" ], "products": [ "species_29370", "species_392417" ], "modifiers": [ [ "species_10537098", "catalyst" ] ], "additional_components": [ "O45318", "WBGene00022501", "Q23083", "WBGene00022501" ] }, "reaction_10537294": { "compartment": "compartment_876", "id": "reaction_10537294", "reactome": "R-CEL-1676149", "name": "PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_202247" ], "products": [ "species_29372", "species_392417" ], "modifiers": [ [ "species_10514327", "catalyst" ] ], "additional_components": [ "WBGene00000913" ] }, "reaction_10537264": { "compartment": "compartment_876", "id": "reaction_10537264", "reactome": "R-CEL-1676109", "name": "PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_392417" ], "products": [ "species_29370", "species_202247" ], "modifiers": [ [ "species_10537261", "catalyst" ] ], "additional_components": [ "G5EDP9", "WBGene00000001", "Q94125", "WBGene00000090", "G5EDY0", "WBGene00009552", "species_74016", "species_114632", "species_266099" ] }, "reaction_10563633": { "compartment": "compartment_70101", "id": "reaction_10563633", "reactome": "R-CEL-6809254", "name": "MTMR8 binds MTMR9", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10563629", "species_10563624" ], "products": [ "species_10563631" ], "modifiers": [], "additional_components": [ "WBGene00003479", "F53A2.8a", "G5ED68", "F53A2.8a", "Q965W9", "WBGene00003479" ] }, "reaction_10537233": { "compartment": "compartment_876", "id": "reaction_10537233", "reactome": "R-CEL-1675994", "name": "PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806276", "species_29356" ], "products": [ "species_29372", "species_426658" ], "modifiers": [ [ "species_10537230", "catalyst" ] ], "additional_components": [ "Q9N589", "WBGene00003475", "Q22712", "WBGene00003476", "G5ECL2", "WBGene00006763", "G5ED68", "F53A2.8a" ] }, "reaction_10563664": { "compartment": "compartment_876", "id": "reaction_10563664", "reactome": "R-CEL-6809325", "name": "PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806276", "species_29356" ], "products": [ "species_29372", "species_426658" ], "modifiers": [ [ "species_10563658", "catalyst" ] ], "additional_components": [ "G5ED68", "F53A2.8a", "Q965W9", "WBGene00003479" ] }, "reaction_10567095": { "compartment": "compartment_20699", "id": "reaction_10567095", "reactome": "R-CEL-8870499", "name": "PLEKHA3,8 bind PI4P, ARF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806217", "species_10567091", "species_10517985" ], "products": [ "species_10567093" ], "modifiers": [], "additional_components": [ "WBGene00022347", "WBGene00000183", "G5EFK4", "WBGene00000183", "Q9BKS2", "WBGene00022347", "species_1806234" ] }, "reaction_10537244": { "compartment": "compartment_876", "id": "reaction_10537244", "reactome": "R-CEL-1676048", "name": "PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10537241", "catalyst" ] ], "additional_components": [ "G5EDP9", "WBGene00000001", "Q94125", "WBGene00000090" ] }, "reaction_10537215": { "compartment": "compartment_876", "id": "reaction_10537215", "reactome": "R-CEL-1675949", "name": "PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_179838" ], "products": [ "species_29372", "species_202247" ], "modifiers": [ [ "species_10537212", "catalyst" ] ], "additional_components": [ "G5EGN9", "WBGene00012016", "P34370", "WBGene00086546" ] }, "reaction_10509393": { "compartment": "compartment_7660", "id": "reaction_10509393", "reactome": "R-CEL-113407", "name": "DSIF complex binds to RNA Pol II (hypophosphorylated)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509356", "species_10509234" ], "products": [ "species_10509358" ], "modifiers": [], "additional_components": [ "Q9XUM4", "WBGene00012236", "P16356", "WBGene00000123", "Q19826", "WBGene00017830", "Q9XVH6", "WBGene00012187", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q9U3I0", "WBGene00009078", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q10578", "WBGene00016140", "Q17684", "WBGene00007355", "O02092", "WBGene00018391", "Q9GR61", "WBGene00021347", "Q9N3C9", "WBGene00021845", "Q93338", "WBGene00007971", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "Q9TZ93", "WBGene00005014", "Q21338", "WBGene00005015", "Q9TZ93", "WBGene00005014", "Q21338", "WBGene00005015", "Q9XUM4", "WBGene00012236", "P16356", "WBGene00000123", "Q19826", "WBGene00017830", "Q9XVH6", "WBGene00012187", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q9U3I0", "WBGene00009078", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q10578", "WBGene00016140", "Q17684", "WBGene00007355", "O02092", "WBGene00018391", "Q9GR61", "WBGene00021347", "Q9N3C9", "WBGene00021845", "Q93338", "WBGene00007971", "Q93594", "WBGene00009141", "O01763", "WBGene00018156" ] }, "reaction_10509363": { "compartment": "compartment_7660", "id": "reaction_10509363", "reactome": "R-CEL-112383", "name": "Hypophosphorylation of RNA Pol II CTD by FCP1P protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10506316", "species_10504427", "species_10509239" ], "products": [ "species_10506316", "species_10509356" ], "modifiers": [ [ "species_10509239", "catalyst" ] ], "additional_components": [ "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "WBGene00012236", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q9XUM4", "WBGene00012236", "P16356", "WBGene00000123", "Q19826", "WBGene00017830", "Q9XVH6", "WBGene00012187", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q9U3I0", "WBGene00009078", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q10578", "WBGene00016140", "Q17684", "WBGene00007355", "O02092", "WBGene00018391", "Q9GR61", "WBGene00021347", "Q9N3C9", "WBGene00021845", "Q93338", "WBGene00007971", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "WBGene00012236" ] }, "reaction_10509381": { "compartment": "compartment_7660", "id": "reaction_10509381", "reactome": "R-CEL-112396", "name": "Separation of elongating transcript from template", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509377" ], "products": [ "species_10509379" ], "modifiers": [], "additional_components": [ "Q9TXQ9", "WBGene00017011", "Q9TVL3", "WBGene00000410", "P34424", "WBGene00000508", "P34425", "WBGene00000507", "O17869", "WBGene00009650", "Q9N5R9", "WBGene00018849", "P41848", "WBGene00001974", "species_110614", "species_29358", "species_29494", "species_29438", "P34703", "WBGene00001259", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q9N554", "WBGene00021281", "Q9TZ93", "WBGene00005014", "Q21338", "WBGene00005015", "H2KYV0", "WBGene00016115", "P52652", "WBGene00012000", "Q9XUM4", "WBGene00012236", "Q09413", "WBGene00010990", "Q9BKS1", "WBGene00001236", "G5ECR7", "WBGene00001235", "G5EBY0", "WBGene00009103", "Q03560", "WBGene00007184", "A5Z2V7", "WBGene00008533", "Q17431", "WBGene00007110", "P90783", "WBGene00008338", "Q9N5U5", "WBGene00018064", "Q19375", "WBGene00008729", "Q9TXQ9", "WBGene00017011", "Q9TVL3", "WBGene00000410", "P34424", "WBGene00000508", "P34425", "WBGene00000507", "O17869", "WBGene00009650", "Q9N5R9", "WBGene00018849", "P41848", "WBGene00001974", "species_110614", "species_29358", "species_29494", "species_29438", "P34703", "WBGene00001259", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q9N554", "WBGene00021281", "Q9TZ93", "WBGene00005014", "Q21338", "WBGene00005015", "H2KYV0", "WBGene00016115", "P52652", "WBGene00012000", "Q9XUM4", "WBGene00012236", "Q09413", "WBGene00010990", "Q9BKS1", "WBGene00001236", "G5ECR7", "WBGene00001235", "G5EBY0", "WBGene00009103", "Q03560", "WBGene00007184", "A5Z2V7", "WBGene00008533", "Q17431", "WBGene00007110", "P90783", "WBGene00008338", "Q9N5U5", "WBGene00018064", "Q19375", "WBGene00008729" ] }, "reaction_10509367": { "compartment": "compartment_7660", "id": "reaction_10509367", "reactome": "R-CEL-112385", "name": "Addition of nucleotides leads to transcript elongation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509350", "species_30595" ], "products": [ "species_10506316", "species_10509365" ], "modifiers": [], "additional_components": [ "Q9N5R9", "WBGene00018849", "P41848", "WBGene00001974", "P34703", "WBGene00001259", "H2KYV0", "WBGene00016115", "P52652", "WBGene00012000", "Q09413", "WBGene00010990", "Q9BKS1", "WBGene00001236", "G5ECR7", "WBGene00001235", "G5EBY0", "WBGene00009103", "Q03560", "WBGene00007184", "A5Z2V7", "WBGene00008533", "Q17431", "WBGene00007110", "P90783", "WBGene00008338", "Q9N5U5", "WBGene00018064", "Q9TXQ9", "WBGene00017011", "Q9TVL3", "WBGene00000410", "P34424", "WBGene00000508", "P34425", "WBGene00000507", "O17869", "WBGene00009650", "Q9TZ93", "WBGene00005014", "Q21338", "WBGene00005015", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q9XUM4", "WBGene00012236", "Q9N554", "WBGene00021281", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q19375", "WBGene00008729", "species_110614", "species_29358", "species_29494", "species_29438", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q9TXQ9", "WBGene00017011", "Q9TVL3", "WBGene00000410", "P34424", "WBGene00000508", "P34425", "WBGene00000507", "O17869", "WBGene00009650", "Q9N5R9", "WBGene00018849", "P41848", "WBGene00001974", "species_110614", "species_29358", "species_29494", "species_29438", "P34703", "WBGene00001259", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q9N554", "WBGene00021281", "Q9TZ93", "WBGene00005014", "Q21338", "WBGene00005015", "H2KYV0", "WBGene00016115", "P52652", "WBGene00012000", "Q9XUM4", "WBGene00012236", "Q09413", "WBGene00010990", "Q9BKS1", "WBGene00001236", "G5ECR7", "WBGene00001235", "G5EBY0", "WBGene00009103", "Q03560", "WBGene00007184", "A5Z2V7", "WBGene00008533", "Q17431", "WBGene00007110", "P90783", "WBGene00008338", "Q9N5U5", "WBGene00018064", "Q19375", "WBGene00008729" ] }, "reaction_10509399": { "compartment": "compartment_7660", "id": "reaction_10509399", "reactome": "R-CEL-113412", "name": "Pol II elongation complex moves on the template as transcript elongates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509365", "species_30595" ], "products": [ "species_30595", "species_10509377" ], "modifiers": [], "additional_components": [ "Q9TXQ9", "WBGene00017011", "Q9TVL3", "WBGene00000410", "P34424", "WBGene00000508", "P34425", "WBGene00000507", "O17869", "WBGene00009650", "Q9N5R9", "WBGene00018849", "P41848", "WBGene00001974", "species_110614", "species_29358", "species_29494", "species_29438", "P34703", "WBGene00001259", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q9N554", "WBGene00021281", "Q9TZ93", "WBGene00005014", "Q21338", "WBGene00005015", "H2KYV0", "WBGene00016115", "P52652", "WBGene00012000", "Q9XUM4", "WBGene00012236", "Q09413", "WBGene00010990", "Q9BKS1", "WBGene00001236", "G5ECR7", "WBGene00001235", "G5EBY0", "WBGene00009103", "Q03560", "WBGene00007184", "A5Z2V7", "WBGene00008533", "Q17431", "WBGene00007110", "P90783", "WBGene00008338", "Q9N5U5", "WBGene00018064", "Q19375", "WBGene00008729", "species_110614", "species_29358", "species_29494", "species_29438", "species_110614", "species_29358", "species_29494", "species_29438", "Q9TXQ9", "WBGene00017011", "Q9TVL3", "WBGene00000410", "P34424", "WBGene00000508", "P34425", "WBGene00000507", "O17869", "WBGene00009650", "Q9N5R9", "WBGene00018849", "P41848", "WBGene00001974", "species_110614", "species_29358", "species_29494", "species_29438", "P34703", "WBGene00001259", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q9N554", "WBGene00021281", "Q9TZ93", "WBGene00005014", "Q21338", "WBGene00005015", "H2KYV0", "WBGene00016115", "P52652", "WBGene00012000", "Q9XUM4", "WBGene00012236", "Q09413", "WBGene00010990", "Q9BKS1", "WBGene00001236", "G5ECR7", "WBGene00001235", "G5EBY0", "WBGene00009103", "Q03560", "WBGene00007184", "A5Z2V7", "WBGene00008533", "Q17431", "WBGene00007110", "P90783", "WBGene00008338", "Q9N5U5", "WBGene00018064", "Q19375", "WBGene00008729" ] }, "reaction_10509352": { "compartment": "compartment_7660", "id": "reaction_10509352", "reactome": "R-CEL-112379", "name": "Recruitment of elongation factors to form elongation complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509343", "species_10506316", "species_10509259", "species_10509338", "species_10509306", "species_10509271", "species_10509348", "species_10509283" ], "products": [ "species_10509350" ], "modifiers": [], "additional_components": [ "WBGene00008729", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q9TXQ9", "WBGene00017011", "Q9TVL3", "WBGene00000410", "P34424", "WBGene00000508", "P34425", "WBGene00000507", "O17869", "WBGene00009650", "Q9TZ93", "WBGene00005014", "Q21338", "WBGene00005015", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q9XUM4", "WBGene00012236", "Q9N554", "WBGene00021281", "G5EBY0", "WBGene00009103", "Q03560", "WBGene00007184", "A5Z2V7", "WBGene00008533", "Q17431", "WBGene00007110", "P90783", "WBGene00008338", "Q9N5U5", "WBGene00018064", "Q09413", "WBGene00010990", "Q9BKS1", "WBGene00001236", "G5ECR7", "WBGene00001235", "H2KYV0", "WBGene00016115", "P52652", "WBGene00012000", "WBGene00001259", "Q9N5R9", "WBGene00018849", "P41848", "WBGene00001974", "Q9N5R9", "WBGene00018849", "P41848", "WBGene00001974", "P34703", "WBGene00001259", "H2KYV0", "WBGene00016115", "P52652", "WBGene00012000", "Q09413", "WBGene00010990", "Q9BKS1", "WBGene00001236", "G5ECR7", "WBGene00001235", "G5EBY0", "WBGene00009103", "Q03560", "WBGene00007184", "A5Z2V7", "WBGene00008533", "Q17431", "WBGene00007110", "P90783", "WBGene00008338", "Q9N5U5", "WBGene00018064", "Q9TXQ9", "WBGene00017011", "Q9TVL3", "WBGene00000410", "P34424", "WBGene00000508", "P34425", "WBGene00000507", "O17869", "WBGene00009650", "Q9TZ93", "WBGene00005014", "Q21338", "WBGene00005015", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q9XUM4", "WBGene00012236", "Q9N554", "WBGene00021281", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q19375", "WBGene00008729" ] }, "reaction_10510498": { "compartment": "compartment_876", "id": "reaction_10510498", "reactome": "R-CEL-165026", "name": "OCTN2 / SLC22A5 transports CAR from extracellular space to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_164988", "species_74113" ], "products": [ "species_30235", "species_83910" ], "modifiers": [ [ "species_10510495", "catalyst" ] ], "additional_components": [ "G5EEI9", "WBGene00044455", "Q18795", "WBGene00008271", "G5EGL6", "WBGene00044455", "Q23501", "WBGene00003843", "O18247", "WBGene00044455", "Q4PIX1", "WBGene00044455", "P46499", "WBGene00044455", "Q9BKR9", "WBGene00044455", "Q09617", "WBGene00044455", "A0A0K3AWD3", "WBGene00044455", "Q9U539", "WBGene00003842", "Q18613", "WBGene00044455", "A0A238UKL7", "WBGene00044455", "Q9UAW9", "WBGene00044455", "Q18655", "WBGene00044455" ] }, "reaction_10514514": { "compartment": "compartment_70616", "id": "reaction_10514514", "reactome": "R-CEL-200410", "name": "palmitoylcarnitine + CoASH => palmitoyl-CoA + carnitine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_201050" ], "products": [ "species_201023", "species_77281" ], "modifiers": [ [ "species_10514511", "catalyst" ] ], "additional_components": [ "WBGene00011122" ] }, "reaction_10514597": { "compartment": "compartment_17927", "id": "reaction_10514597", "reactome": "R-CEL-200424", "name": "Exchange of palmitoylcarnitine and carnitine across the inner mitochondrial membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_201023", "species_201034" ], "products": [ "species_549207", "species_201050" ], "modifiers": [ [ "species_10514594", "catalyst" ] ], "additional_components": [ "WBGene00000996" ] }, "reaction_10567572": { "compartment": "compartment_70101", "id": "reaction_10567572", "reactome": "R-CEL-8876889", "name": "Btn-ACACB:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111627", "species_113592", "species_76183" ], "products": [ "species_29372", "species_29370", "species_29508" ], "modifiers": [ [ "species_10514577", "catalyst" ], [ "species_76190", "catalyst" ] ], "additional_components": [ "species_266099", "H2L0M0", "WBGene00004076" ] }, "reaction_10507418": { "compartment": "compartment_70101", "id": "reaction_10507418", "reactome": "R-CEL-75851", "name": "Btn-ACACA:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111627", "species_113592", "species_76183" ], "products": [ "species_29372", "species_29370", "species_29508" ], "modifiers": [ [ "species_10507415", "catalyst" ], [ "species_76190", "catalyst" ] ], "additional_components": [ "Q9XUC3", "WBGene00012131", "H2L0M0", "WBGene00004076", "species_266099" ] }, "reaction_10514589": { "compartment": "compartment_70101", "id": "reaction_10514589", "reactome": "R-CEL-200423", "name": "pAMPK inactivates ACACB, inhibiting malonyl-CoA synthesis", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10514577" ], "products": [ "species_29370", "species_10514584" ], "modifiers": [ [ "species_10514586", "catalyst" ] ], "additional_components": [ "species_266099", "H2L0M0", "WBGene00004076", "H2L0M0", "WBGene00004076", "species_266099", "Q9XUY2", "WBGene00010115", "A0A1T5HUK9", "WBGene00013732", "H2L0K0", "WBGene00020135", "O02168", "WBGene00020633", "Q9N501", "WBGene00021527", "Q95ZQ4", "WBGene00020142" ] }, "reaction_10554146": { "compartment": "compartment_13949", "id": "reaction_10554146", "reactome": "R-CEL-5638014", "name": "RAB11A:GTP-containing Golgi vesicles recruit RAB3IP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10554142", "species_10552808" ], "products": [ "species_10554144" ], "modifiers": [], "additional_components": [ "O01803", "WBGene00004274", "species_29438", "WBGene00010045", "Q20759", "WBGene00010045", "O01803", "WBGene00004274", "species_29438" ] }, "reaction_10517298": { "compartment": "compartment_984", "id": "reaction_10517298", "reactome": "R-CEL-216045", "name": "Collagen type I binds integrin alpha11beta1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10517294", "species_10509625", "species_114632" ], "products": [ "species_10517296" ], "modifiers": [], "additional_components": [ "Q27874", "WBGene00003930", "P34446", "WBGene00003929", "Q9N4U2", "WBGene00000647", "species_114632", "Q9N4U2", "WBGene00000647", "Q27874", "WBGene00003930", "P34446", "WBGene00003929" ] }, "reaction_10549011": { "compartment": "compartment_984", "id": "reaction_10549011", "reactome": "R-CEL-4088264", "name": "Endostatin binds integrin alphaVbeta3, alphaVbeta5, alpha3beta1, alpha5beta1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10549007", "species_10543255" ], "products": [ "species_10549009" ], "modifiers": [], "additional_components": [ "P34446", "WBGene00003929", "Q27874", "WBGene00003930", "Q03600", "WBGene00002081", "WBGene00000702", "Q19368", "WBGene00000702", "P34446", "WBGene00003929", "Q27874", "WBGene00003930", "Q03600", "WBGene00002081" ] }, "reaction_10517427": { "compartment": "compartment_984", "id": "reaction_10517427", "reactome": "R-CEL-216068", "name": "Interaction of integrin alpha9beta1 with Tenascin-C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10517423", "species_10517415" ], "products": [ "species_10517425" ], "modifiers": [], "additional_components": [ "Q27874", "WBGene00003930", "P34446", "WBGene00003929", "Q18096", "WBGene00007687", "Q18096", "WBGene00007687", "Q27874", "WBGene00003930", "P34446", "WBGene00003929" ] }, "reaction_10517398": { "compartment": "compartment_984", "id": "reaction_10517398", "reactome": "R-CEL-216050", "name": "Integrins alpha4beta1, alpha8beta1, alphaVbeta1, alphaVbeta3, alphaVbeta6 bind Fibronectin matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10517394", "species_10517392" ], "products": [ "species_10517396" ], "modifiers": [], "additional_components": [ "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769", "Q27874", "WBGene00003930", "P34446", "WBGene00003929", "Q27874", "WBGene00003930", "P34446", "WBGene00003929", "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769" ] }, "reaction_10544599": { "compartment": "compartment_876", "id": "reaction_10544599", "reactome": "R-CEL-2484965", "name": "Collagen type XIII binds Integrin alpha1beta1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10542932", "species_10543907" ], "products": [ "species_10544597" ], "modifiers": [], "additional_components": [ "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689", "Q27874", "WBGene00003930", "P34446", "WBGene00003929", "Q27874", "WBGene00003930", "P34446", "WBGene00003929", "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689" ] }, "reaction_10517290": { "compartment": "compartment_984", "id": "reaction_10517290", "reactome": "R-CEL-216043", "name": "Collagen type II binds integrin alpha10beta1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_114632", "species_10517286", "species_10517168" ], "products": [ "species_10517288" ], "modifiers": [], "additional_components": [ "O76368", "WBGene00000674", "Q09457", "WBGene00000251", "Q9N4U2", "WBGene00000647", "Q27874", "WBGene00003930", "P34446", "WBGene00003929", "Q27874", "WBGene00003930", "P34446", "WBGene00003929", "O76368", "WBGene00000674", "Q09457", "WBGene00000251", "Q9N4U2", "WBGene00000647", "species_114632" ] }, "reaction_10543915": { "compartment": "compartment_876", "id": "reaction_10543915", "reactome": "R-CEL-2327695", "name": "Collagen types III, IV, V, VI, VIII, IX, XVI bind integrins alpha1beta1 and alpha2beta1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10543911", "species_10543909" ], "products": [ "species_10543913" ], "modifiers": [], "additional_components": [ "Q9N4U2", "WBGene00000647", "O76368", "WBGene00000674", "Q09457", "WBGene00000251", "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689", "P17140", "WBGene00002280", "Q27874", "WBGene00003930", "P34446", "WBGene00003929", "Q27874", "WBGene00003930", "P34446", "WBGene00003929", "Q9N4U2", "WBGene00000647", "O76368", "WBGene00000674", "Q09457", "WBGene00000251", "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689", "P17140", "WBGene00002280" ] }, "reaction_10517419": { "compartment": "compartment_984", "id": "reaction_10517419", "reactome": "R-CEL-216064", "name": "Interaction of integrin alpha8beta1 with Tenascin-C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10517386", "species_10517415" ], "products": [ "species_10517417" ], "modifiers": [], "additional_components": [ "Q27874", "WBGene00003930", "P34446", "WBGene00003929", "Q18096", "WBGene00007687", "Q18096", "WBGene00007687", "Q27874", "WBGene00003930", "P34446", "WBGene00003929" ] }, "reaction_10503155": { "compartment": "compartment_70101", "id": "reaction_10503155", "reactome": "R-CEL-70523", "name": "PXLP-K314-GPT transaminates L-Ala to form PYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29406", "species_29432" ], "products": [ "species_29404", "species_29398" ], "modifiers": [ [ "species_10503152", "catalyst" ] ], "additional_components": [ "O01685", "WBGene00016333" ] }, "reaction_10527117": { "compartment": "compartment_5460", "id": "reaction_10527117", "reactome": "R-CEL-507749", "name": "PXLP-K341-GPT2 transaminates PYR to form L-Ala", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113557", "species_113552" ], "products": [ "species_113594", "species_379697" ], "modifiers": [ [ "species_10527114", "catalyst" ] ], "additional_components": [ "O01685", "WBGene00016333" ] }, "reaction_10522765": { "compartment": "compartment_70101", "id": "reaction_10522765", "reactome": "R-CEL-426520", "name": "Endonucleolytic RISC hydrolyzes target RNAs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426523" ], "products": [ "species_426511" ], "modifiers": [ [ "species_10522752", "catalyst" ] ], "additional_components": [ "G5EES3", "WBGene00000105" ] }, "reaction_10571586": { "compartment": "compartment_70101", "id": "reaction_10571586", "reactome": "R-CEL-9029987", "name": "p-S216-CDC25C translocates to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10507015" ], "products": [ "species_10507019" ], "modifiers": [], "additional_components": [ "WBGene00000389", "WBGene00000389" ] }, "reaction_10507368": { "compartment": "compartment_7660", "id": "reaction_10507368", "reactome": "R-CEL-75809", "name": "Phosphorylation of Cdc25C at Ser216 by CHEK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10507012" ], "products": [ "species_113582", "species_10507015" ], "modifiers": [ [ "species_10502800", "catalyst" ] ], "additional_components": [ "WBGene00000389", "WBGene00000389", "WBGene00000499" ] }, "reaction_10572187": { "compartment": "compartment_7660", "id": "reaction_10572187", "reactome": "R-CEL-9617067", "name": "All-trans retinoic acid binds RARA:RXRA at the promoter of the CEBPE gene", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5334804", "species_10572179" ], "products": [ "species_10572185" ], "modifiers": [], "additional_components": [ "Q9XUK7", "WBGene00003675", "P41830", "WBGene00004786", "Q10902", "WBGene00003601", "Q20765", "WBGene00003606", "Q9U2R6", "WBGene00003681", "Q9XUK7", "WBGene00003675", "P41830", "WBGene00004786", "Q10902", "WBGene00003601", "Q20765", "WBGene00003606", "species_5334816", "Q9U2R6", "WBGene00003681" ] }, "reaction_10520037": { "compartment": "compartment_7660", "id": "reaction_10520037", "reactome": "R-CEL-381262", "name": "Formation of PPARG:RXRA heterodimer (ARF6 complex)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10514477", "species_10519413" ], "products": [ "species_10520035" ], "modifiers": [], "additional_components": [ "WBGene00003681", "Q20765", "WBGene00003606", "Q9XUK7", "WBGene00003675", "P41830", "WBGene00004786", "Q10902", "WBGene00003601", "Q20765", "WBGene00003606", "Q9XUK7", "WBGene00003675", "P41830", "WBGene00004786", "Q10902", "WBGene00003601", "Q9U2R6", "WBGene00003681" ] }, "reaction_10535206": { "compartment": "compartment_7660", "id": "reaction_10535206", "reactome": "R-CEL-1535903", "name": "Phospho R-SMAD(SMAD2/3):CO-SMAD(SMAD4):FOXO3 binds FoxO3a-binding elements", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10511518", "species_1535904", "species_10514276" ], "products": [ "species_10535204" ], "modifiers": [], "additional_components": [ "P45897", "WBGene00004858", "Q21733", "WBGene00000904", "WBGene00000912", "O16850", "WBGene00000912", "P45897", "WBGene00004858", "Q21733", "WBGene00000904" ] }, "reaction_10525296": { "compartment": "compartment_7660", "id": "reaction_10525296", "reactome": "R-CEL-448955", "name": "Phosphorylation of MEF2 proteins by p38", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10525266", "species_10525280" ], "products": [ "species_113582", "species_10525293" ], "modifiers": [ [ "species_10525280", "catalyst" ] ], "additional_components": [ "WBGene00003182", "Q17446", "WBGene00004055", "Q8MXI4", "WBGene00004056", "Q17446", "WBGene00004055", "Q8MXI4", "WBGene00004056", "Q9U325", "WBGene00003182", "Q17446", "WBGene00004055", "Q8MXI4", "WBGene00004056" ] }, "reaction_10525370": { "compartment": "compartment_7660", "id": "reaction_10525370", "reactome": "R-CEL-448963", "name": "Interaction of MyoD:E protein with MEF2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10525291", "species_10525366" ], "products": [ "species_10525368" ], "modifiers": [], "additional_components": [ "Q9U325", "WBGene00003182", "P22980", "WBGene00001948", "G5EEG9", "WBGene00001949", "P22980", "WBGene00001948", "G5EEG9", "WBGene00001949", "Q9U325", "WBGene00003182" ] }, "reaction_10518843": { "compartment": "compartment_876", "id": "reaction_10518843", "reactome": "R-CEL-375138", "name": "CDO binds BOC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10518839", "species_10518837" ], "products": [ "species_10518841" ], "modifiers": [], "additional_components": [ "WBGene00004732", "WBGene00004732", "Q53U87", "WBGene00004732" ] }, "reaction_10525341": { "compartment": "compartment_876", "id": "reaction_10525341", "reactome": "R-CEL-448958", "name": "Nuclear translocation of p38 MAPK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10525339" ], "products": [ "species_10525337", "species_10525280" ], "modifiers": [], "additional_components": [ "P34609", "WBGene00006755", "Q53U87", "WBGene00004732", "O44326", "WBGene00001979", "P90947", "WBGene00001978", "Q05062", "WBGene00000390", "species_29438", "P03949", "WBGene00000018", "Q17446", "WBGene00004055", "Q8MXI4", "WBGene00004056", "P34609", "WBGene00006755", "Q53U87", "WBGene00004732", "O44326", "WBGene00001979", "P90947", "WBGene00001978", "Q05062", "WBGene00000390", "species_29438", "P03949", "WBGene00000018", "Q17446", "WBGene00004055", "Q8MXI4", "WBGene00004056" ] }, "reaction_10544128": { "compartment": "compartment_876", "id": "reaction_10544128", "reactome": "R-CEL-2396029", "name": "Latent TGF-beta-3 binds integrins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10517390", "species_10544124" ], "products": [ "species_10544126" ], "modifiers": [], "additional_components": [ "Q27874", "WBGene00003930", "P34446", "WBGene00003929", "G5EEL5", "WBGene00000936", "G5EBY8", "WBGene00006852", "G5EEL5", "WBGene00000936", "G5EBY8", "WBGene00006852", "Q27874", "WBGene00003930", "P34446", "WBGene00003929" ] }, "reaction_10544040": { "compartment": "compartment_876", "id": "reaction_10544040", "reactome": "R-CEL-2395320", "name": "Latent TGF-beta-1 binds integrins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10544036", "species_10544034" ], "products": [ "species_10544038" ], "modifiers": [], "additional_components": [ "Q27874", "WBGene00003930", "P34446", "WBGene00003929", "G5EBY8", "WBGene00006852", "G5EEL5", "WBGene00000936", "G5EBY8", "WBGene00006852", "G5EEL5", "WBGene00000936", "Q27874", "WBGene00003930", "P34446", "WBGene00003929" ] }, "reaction_10544857": { "compartment": "compartment_984", "id": "reaction_10544857", "reactome": "R-CEL-2537665", "name": "Fibulin-1 and -2 bind fibronectin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10517394", "species_10535682" ], "products": [ "species_10544855" ], "modifiers": [], "additional_components": [ "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769", "WBGene00007170", "Q17494", "WBGene00007170", "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769" ] }, "reaction_10530641": { "compartment": "compartment_70101", "id": "reaction_10530641", "reactome": "R-CEL-977333", "name": "PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_977329", "species_29404" ], "products": [ "species_29406", "species_936706" ], "modifiers": [ [ "species_10530638", "catalyst" ] ], "additional_components": [ "P91856", "WBGene00009177" ] }, "reaction_10530630": { "compartment": "compartment_70101", "id": "reaction_10530630", "reactome": "R-CEL-977324", "name": "PSPH:Mg2+ dimer dephosphorylates O-P-Ser", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_936706" ], "products": [ "species_29372", "species_200736" ], "modifiers": [ [ "species_10530627", "catalyst" ] ], "additional_components": [ "A0A061ACK7", "WBGene00013379", "species_114632" ] }, "reaction_10568102": { "compartment": "compartment_70101", "id": "reaction_10568102", "reactome": "R-CEL-8932980", "name": "SERINC3,5,(1,2,4) transport L-Ser from cytosol to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200736" ], "products": [ "species_8932979" ], "modifiers": [ [ "species_10568099", "catalyst" ] ], "additional_components": [ "Q95XV3", "WBGene00021956", "O45719", "WBGene00021956" ] }, "reaction_10571288": { "compartment": "compartment_70101", "id": "reaction_10571288", "reactome": "R-CEL-9014741", "name": "PXLP-K56-SRR dimer deaminates D-Ser", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_376186" ], "products": [ "species_29356", "species_29382", "species_29398" ], "modifiers": [ [ "species_10571285", "catalyst" ], [ "species_29926", "catalyst" ], [ "species_113592", "catalyst" ] ], "additional_components": [ "Q93968", "WBGene00011353" ] }, "reaction_10571291": { "compartment": "compartment_70101", "id": "reaction_10571291", "reactome": "R-CEL-9014766", "name": "PXLP-K56-SRR dimer isomerises L-Ser to D-Ser", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200736" ], "products": [ "species_376186" ], "modifiers": [ [ "species_10571285", "catalyst" ], [ "species_29926", "catalyst" ], [ "species_113592", "catalyst" ] ], "additional_components": [ "Q93968", "WBGene00011353" ] }, "reaction_10530651": { "compartment": "compartment_70101", "id": "reaction_10530651", "reactome": "R-CEL-977348", "name": "PHGHD tetramer dehydrogenates 3PG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29360", "species_29728" ], "products": [ "species_977329", "species_70106", "species_73473" ], "modifiers": [ [ "species_10530648", "catalyst" ] ], "additional_components": [ "O17626", "WBGene00007836" ] }, "reaction_10571806": { "compartment": "compartment_70101", "id": "reaction_10571806", "reactome": "R-CEL-9034539", "name": "PXLP-K56-SRR dimer deaminates L-Ser", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200736" ], "products": [ "species_29356", "species_29382", "species_29398" ], "modifiers": [ [ "species_10571285", "catalyst" ] ], "additional_components": [ "Q93968", "WBGene00011353" ] }, "reaction_10542969": { "compartment": "compartment_70101", "id": "reaction_10542969", "reactome": "R-CEL-2161195", "name": "abacavir monophosphate + H2O => carbovir monophosphate + cyclopropylamine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_2161194" ], "products": [ "species_2161176", "species_2161175" ], "modifiers": [ [ "species_10542964", "catalyst" ] ], "additional_components": [ "Q8IG39", "WBGene00016632", "species_216785" ] }, "reaction_10543017": { "compartment": "compartment_70101", "id": "reaction_10543017", "reactome": "R-CEL-2162066", "name": "carbovir + IMP => carbovir monophosphate + inosine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2161514", "species_29602" ], "products": [ "species_2161176", "species_83927" ], "modifiers": [ [ "species_10506658", "catalyst" ] ], "additional_components": [ "Q95X21", "WBGene00022201", "species_114632" ] }, "reaction_10543020": { "compartment": "compartment_70101", "id": "reaction_10543020", "reactome": "R-CEL-2162078", "name": "abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2161185", "species_29360" ], "products": [ "species_70106", "species_2162081", "species_73473" ], "modifiers": [ [ "species_10504238", "catalyst" ] ], "additional_components": [ "species_216785", "Q17335", "WBGene00019240" ] }, "reaction_10552511": { "compartment": "compartment_7660", "id": "reaction_10552511", "reactome": "R-CEL-5578742", "name": "AGO1,2:small RNA complexes interact with chromatin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10504431", "species_10552507", "species_10517072" ], "products": [ "species_10552509" ], "modifiers": [], "additional_components": [ "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "G5EES3", "WBGene00000105", "O16720", "WBGene00000106", "O61931", "WBGene00019971", "O62275", "WBGene00010263", "P34681", "WBGene00006449", "Q09249", "WBGene00007624", "Q21691", "WBGene00019862", "Q21770", "WBGene00011061", "Q86NJ8", "WBGene00004093", "Q9N585", "WBGene00004094", "A0A0T7CIX3", "WBGene00019666", "Q9TXN7", "WBGene00020707", "A0A0U1RML5", "WBGene00018921", "Q9XVI3", "WBGene00011945", "D9N120", "WBGene00022877", "G5ED77", "WBGene00011910", "G5EEH0", "WBGene00004323", "H2KZD5", "WBGene00017641", "P62784", "WBGene00001875", "K7ZUH9", "WBGene00001914", "Q10453", "WBGene00001945", "P62784", "WBGene00001875", "K7ZUH9", "WBGene00001914", "Q10453", "WBGene00001945", "G5EES3", "WBGene00000105", "O16720", "WBGene00000106", "O61931", "WBGene00019971", "O62275", "WBGene00010263", "P34681", "WBGene00006449", "Q09249", "WBGene00007624", "Q21691", "WBGene00019862", "Q21770", "WBGene00011061", "Q86NJ8", "WBGene00004093", "Q9N585", "WBGene00004094", "A0A0T7CIX3", "WBGene00019666", "Q9TXN7", "WBGene00020707", "A0A0U1RML5", "WBGene00018921", "Q9XVI3", "WBGene00011945", "D9N120", "WBGene00022877", "G5ED77", "WBGene00011910", "G5EEH0", "WBGene00004323", "H2KZD5", "WBGene00017641", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140" ] }, "reaction_10571531": { "compartment": "compartment_70101", "id": "reaction_10571531", "reactome": "R-CEL-9023912", "name": "AGO2 cleaves passenger strand of duplex siRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10542709" ], "products": [ "species_10571528" ], "modifiers": [ [ "species_10542709", "catalyst" ] ], "additional_components": [ "G5EES3", "WBGene00000105", "G5EES3", "WBGene00000105", "G5EES3", "WBGene00000105" ] }, "reaction_10522748": { "compartment": "compartment_70101", "id": "reaction_10522748", "reactome": "R-CEL-426464", "name": "Dicer cleaves double-stranded RNA to yield double-stranded siRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426463", "species_10515589" ], "products": [ "species_10522745" ], "modifiers": [ [ "species_10515589", "catalyst" ] ], "additional_components": [ "G5EBF5", "WBGene00004326", "P34529", "WBGene00000939", "G5EES3", "WBGene00000105", "P34529", "WBGene00000939", "G5EBF5", "WBGene00004326", "G5EES3", "WBGene00000105", "G5EBF5", "WBGene00004326", "P34529", "WBGene00000939", "G5EES3", "WBGene00000105" ] }, "reaction_10542733": { "compartment": "compartment_70101", "id": "reaction_10542733", "reactome": "R-CEL-2106615", "name": "Removal of siRNA passenger strand", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10542723" ], "products": [ "species_10542731" ], "modifiers": [], "additional_components": [ "G5EBF5", "WBGene00004326", "P34529", "WBGene00000939", "G5EES3", "WBGene00000105", "P34529", "WBGene00000939", "G5EES3", "WBGene00000105", "G5EBF5", "WBGene00004326" ] }, "reaction_10542735": { "compartment": "compartment_70101", "id": "reaction_10542735", "reactome": "R-CEL-2106625", "name": "Duplex siRNA is loaded into Argonaute", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10522745" ], "products": [ "species_10542723" ], "modifiers": [], "additional_components": [ "P34529", "WBGene00000939", "G5EBF5", "WBGene00004326", "G5EES3", "WBGene00000105", "G5EBF5", "WBGene00004326", "P34529", "WBGene00000939", "G5EES3", "WBGene00000105" ] }, "reaction_10536517": { "compartment": "compartment_70101", "id": "reaction_10536517", "reactome": "R-CEL-1614583", "name": "PXLP-K212-CTH cleaves L-Cystathionine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1614518", "species_29356" ], "products": [ "species_111707", "species_29382", "species_936714" ], "modifiers": [ [ "species_10536511", "catalyst" ] ], "additional_components": [ "P55216", "WBGene00022856" ] }, "reaction_10536491": { "compartment": "compartment_70101", "id": "reaction_10536491", "reactome": "R-CEL-1614524", "name": "PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200736", "species_174369" ], "products": [ "species_1614518", "species_29356" ], "modifiers": [ [ "species_10536488", "catalyst" ] ], "additional_components": [ "G5EFH8", "WBGene00013866", "species_71185" ] }, "reaction_10537680": { "compartment": "compartment_7660", "id": "reaction_10537680", "reactome": "R-CEL-1855206", "name": "I(1,3,4,5)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_2023891" ], "products": [ "species_113582", "species_2023901" ], "modifiers": [ [ "species_10537657", "catalyst" ] ], "additional_components": [ "WBGene00014081" ] }, "reaction_10537761": { "compartment": "compartment_7660", "id": "reaction_10537761", "reactome": "R-CEL-1855224", "name": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/2 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_2023940" ], "products": [ "species_113582", "species_2023941" ], "modifiers": [ [ "species_10537560", "catalyst" ] ], "additional_components": [ "O02167", "WBGene00021260", "Q93644", "WBGene00021260", "Q9BKX8", "WBGene00021260" ] }, "reaction_10537683": { "compartment": "compartment_7660", "id": "reaction_10537683", "reactome": "R-CEL-1855207", "name": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/2 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_2023929" ], "products": [ "species_113582", "species_2023940" ], "modifiers": [ [ "species_10537560", "catalyst" ] ], "additional_components": [ "O02167", "WBGene00021260", "Q93644", "WBGene00021260", "Q9BKX8", "WBGene00021260" ] }, "reaction_10537767": { "compartment": "compartment_7660", "id": "reaction_10537767", "reactome": "R-CEL-1855228", "name": "I(1,3,4,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_2023892" ], "products": [ "species_113582", "species_2023901" ], "modifiers": [ [ "species_10537657", "catalyst" ] ], "additional_components": [ "WBGene00014081" ] }, "reaction_10537640": { "compartment": "compartment_7660", "id": "reaction_10537640", "reactome": "R-CEL-1855181", "name": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_2023901" ], "products": [ "species_113582", "species_2023922" ], "modifiers": [ [ "species_10537560", "catalyst" ] ], "additional_components": [ "O02167", "WBGene00021260", "Q93644", "WBGene00021260", "Q9BKX8", "WBGene00021260" ] }, "reaction_10537770": { "compartment": "compartment_7660", "id": "reaction_10537770", "reactome": "R-CEL-1855230", "name": "5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_2023922" ], "products": [ "species_113582", "species_2023948" ], "modifiers": [ [ "species_10537560", "catalyst" ] ], "additional_components": [ "O02167", "WBGene00021260", "Q93644", "WBGene00021260", "Q9BKX8", "WBGene00021260" ] }, "reaction_10537563": { "compartment": "compartment_7660", "id": "reaction_10537563", "reactome": "R-CEL-1855157", "name": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_2023932" ], "products": [ "species_113582", "species_2023931" ], "modifiers": [ [ "species_10537560", "catalyst" ] ], "additional_components": [ "O02167", "WBGene00021260", "Q93644", "WBGene00021260", "Q9BKX8", "WBGene00021260" ] }, "reaction_10537660": { "compartment": "compartment_7660", "id": "reaction_10537660", "reactome": "R-CEL-1855185", "name": "I(1,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_2023935" ], "products": [ "species_113582", "species_2023901" ], "modifiers": [ [ "species_10537657", "catalyst" ] ], "additional_components": [ "WBGene00014081" ] }, "reaction_10537773": { "compartment": "compartment_7660", "id": "reaction_10537773", "reactome": "R-CEL-1855233", "name": "I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by IPMK in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_2023907" ], "products": [ "species_113582", "species_2023891" ], "modifiers": [ [ "species_10537657", "catalyst" ] ], "additional_components": [ "WBGene00014081" ] }, "reaction_10537614": { "compartment": "compartment_7660", "id": "reaction_10537614", "reactome": "R-CEL-1855176", "name": "I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK (IP5-2K) in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_2023901" ], "products": [ "species_113582", "species_2023929" ], "modifiers": [ [ "species_10537611", "catalyst" ] ], "additional_components": [ "WBGene00012466" ] }, "reaction_10509797": { "compartment": "compartment_17951", "id": "reaction_10509797", "reactome": "R-CEL-141348", "name": "PAO:FAD oxidises NASPM to PTCN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113535", "species_141343", "species_141349" ], "products": [ "species_141327", "species_113575", "species_141350" ], "modifiers": [ [ "species_10509794", "catalyst" ] ], "additional_components": [ "O76383", "WBGene00016061", "species_113596" ] }, "reaction_10518005": { "compartment": "compartment_70101", "id": "reaction_10518005", "reactome": "R-CEL-351207", "name": "Spermine => N-acetylated spermine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_353560", "species_76183" ], "products": [ "species_76194", "species_353575" ], "modifiers": [ [ "species_10518002", "catalyst" ] ], "additional_components": [ "WBGene00008408" ] }, "reaction_10518007": { "compartment": "compartment_70101", "id": "reaction_10518007", "reactome": "R-CEL-351208", "name": "Spermidine => N-acetylated spermidine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_204635", "species_76183" ], "products": [ "species_353555", "species_76194" ], "modifiers": [ [ "species_10518002", "catalyst" ] ], "additional_components": [ "WBGene00008408" ] }, "reaction_10509799": { "compartment": "compartment_17951", "id": "reaction_10509799", "reactome": "R-CEL-141351", "name": "PAOX:FAD oxidises NASPN to SPM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113535", "species_141343", "species_141323" ], "products": [ "species_141324", "species_141327", "species_113575" ], "modifiers": [ [ "species_10509794", "catalyst" ] ], "additional_components": [ "O76383", "WBGene00016061", "species_113596" ] }, "reaction_10518160": { "compartment": "compartment_70101", "id": "reaction_10518160", "reactome": "R-CEL-353125", "name": "26S proteosome degrades ODC holoenzyme complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10517946" ], "products": [ "species_10517940" ], "modifiers": [ [ "species_10502572", "catalyst" ] ], "additional_components": [ "Q9NHZ6", "WBGene00022748", "P41931", "WBGene00003844", "O01579", "WBGene00018764", "WBGene00022748", "P91477", "WBGene00003950", "Q95PZ7", "WBGene00013435", "Q18115", "WBGene00004459", "O62102", "WBGene00003948", "O17071", "WBGene00004504", "Q10920", "WBGene00016623", "P34286", "WBGene00003952", "Q9XTT9", "WBGene00004506", "Q23449", "WBGene00004468", "Q95005", "WBGene00003925", "P46502", "WBGene00004503", "O61792", "WBGene00004464", "O17586", "WBGene00003922", "O76371", "WBGene00004505", "Q20585", "WBGene00004463", "Q95008", "WBGene00003926", "Q18787", "WBGene00004501", "Q20058", "WBGene00009445", "Q9N599", "WBGene00003924", "O16368", "WBGene00004502", "O61742", "WBGene00004466", "Q09583", "WBGene00003928", "Q966I8", "WBGene00003947", "Q04908", "WBGene00004460", "Q9XUV0", "WBGene00003951", "Q27488", "WBGene00003923", "Q9GZH5", "WBGene00004458", "O44156", "WBGene00003927", "Q22253", "WBGene00004465", "O76577", "WBGene00004467", "P90868", "WBGene00003953", "Q19324", "WBGene00004461", "Q17971", "WBGene00007588", "Q23237", "WBGene00003949", "Q20938", "WBGene00004462" ] }, "reaction_10517948": { "compartment": "compartment_70101", "id": "reaction_10517948", "reactome": "R-CEL-350567", "name": "Antizyme OAZ binds to Ornithine decarboxylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10503318", "species_10517940" ], "products": [ "species_10517946" ], "modifiers": [], "additional_components": [ "P41931", "WBGene00003844", "O01579", "WBGene00018764", "WBGene00022748", "Q9NHZ6", "WBGene00022748", "P41931", "WBGene00003844", "O01579", "WBGene00018764" ] }, "reaction_10517965": { "compartment": "compartment_70101", "id": "reaction_10517965", "reactome": "R-CEL-350600", "name": "Antizyme inhibitor binds to OAZ and stablizes ODC complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10517946", "species_10517959" ], "products": [ "species_10517963" ], "modifiers": [], "additional_components": [ "Q9NHZ6", "WBGene00022748", "P41931", "WBGene00003844", "O01579", "WBGene00018764", "O01579", "WBGene00018764", "P41931", "WBGene00003844", "P41931", "WBGene00003844", "O01579", "WBGene00018764", "Q9NHZ6", "WBGene00022748" ] }, "reaction_10517953": { "compartment": "compartment_70101", "id": "reaction_10517953", "reactome": "R-CEL-350598", "name": "Arginine<=>Agmatine+CO2", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29468" ], "products": [ "species_113528", "species_351164" ], "modifiers": [ [ "species_10517950", "catalyst" ] ], "additional_components": [ "WBGene00003844" ] }, "reaction_10518023": { "compartment": "compartment_70101", "id": "reaction_10518023", "reactome": "R-CEL-351222", "name": "S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71284" ], "products": [ "species_353113", "species_113528" ], "modifiers": [ [ "species_10518020", "catalyst" ] ], "additional_components": [ "WBGene00004875" ] }, "reaction_10503321": { "compartment": "compartment_70101", "id": "reaction_10503321", "reactome": "R-CEL-70692", "name": "ornithine => putrescine + CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29498" ], "products": [ "species_29610", "species_113528" ], "modifiers": [ [ "species_10503318", "catalyst" ] ], "additional_components": [ "P41931", "WBGene00003844", "O01579", "WBGene00018764" ] }, "reaction_10518015": { "compartment": "compartment_70101", "id": "reaction_10518015", "reactome": "R-CEL-351215", "name": "Putrescine + dc-Adenosyl methionine => Spermidine + 5'-methylthioadenosine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_353113", "species_29610" ], "products": [ "species_204635", "species_353106" ], "modifiers": [ [ "species_10518012", "catalyst" ] ], "additional_components": [ "WBGene00012909" ] }, "reaction_10537235": { "compartment": "compartment_172574", "id": "reaction_10537235", "reactome": "R-CEL-1676024", "name": "PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1806195" ], "products": [ "species_1806198", "species_29370" ], "modifiers": [ [ "species_10537193", "catalyst" ] ], "additional_components": [ "Q9TXI7", "WBGene00006932", "species_266099", "Q23669", "WBGene00014151", "G5EDY0", "WBGene00009552", "species_74016", "species_114632" ] }, "reaction_10537123": { "compartment": "compartment_172574", "id": "reaction_10537123", "reactome": "R-CEL-1675795", "name": "PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806198", "species_29356" ], "products": [ "species_29372", "species_1806195" ], "modifiers": [ [ "species_10537120", "catalyst" ] ], "additional_components": [ "Q9N589", "WBGene00003475", "Q22712", "WBGene00003476", "G5ED68", "F53A2.8a" ] }, "reaction_10537247": { "compartment": "compartment_172574", "id": "reaction_10537247", "reactome": "R-CEL-1676065", "name": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1806289" ], "products": [ "species_1806212", "species_29372" ], "modifiers": [ [ "species_10537120", "catalyst" ] ], "additional_components": [ "Q9N589", "WBGene00003475", "Q22712", "WBGene00003476", "G5ED68", "F53A2.8a" ] }, "reaction_10573048": { "compartment": "compartment_7660", "id": "reaction_10573048", "reactome": "R-CEL-9668902", "name": "Formation of the CTF18-RFC(7s) complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502620", "species_10502635", "species_10511819", "species_10502630", "species_10502625" ], "products": [ "species_10511821" ], "modifiers": [], "additional_components": [ "WBGene00018409", "WBGene00004338", "Q22664", "WBGene00011915", "O44992", "WBGene00019595", "Q21350", "WBGene00010676", "WBGene00004339", "WBGene00004340", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "Q22664", "WBGene00011915", "O44992", "WBGene00019595", "Q21350", "WBGene00010676", "O44175", "WBGene00004338", "P34429", "WBGene00018409" ] }, "reaction_10573050": { "compartment": "compartment_7660", "id": "reaction_10573050", "reactome": "R-CEL-9668904", "name": "Formation of the CTF18 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10511807", "species_10511817", "species_10511812" ], "products": [ "species_10511819" ], "modifiers": [], "additional_components": [ "WBGene00010676", "WBGene00019595", "WBGene00011915", "Q22664", "WBGene00011915", "O44992", "WBGene00019595", "Q21350", "WBGene00010676" ] }, "reaction_10555879": { "compartment": "compartment_7660", "id": "reaction_10555879", "reactome": "R-CEL-5685953", "name": "SIRT6 deacetylates RBBP8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10555871", "species_427523" ], "products": [ "species_427497", "species_427498", "species_10555659" ], "modifiers": [ [ "species_10555876", "catalyst" ] ], "additional_components": [ "Q18606", "WBGene00008082", "Q18606", "WBGene00008082", "WBGene00004803" ] }, "reaction_10506532": { "compartment": "compartment_7660", "id": "reaction_10506532", "reactome": "R-CEL-73946", "name": "Abortive initiation after formation of the first phosphodiester bond", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10506530" ], "products": [ "species_10506316", "species_10506438", "species_10506516", "species_109877", "species_10506433", "species_10504433", "species_10506528" ], "modifiers": [], "additional_components": [ "G5EG49", "WBGene00013998", "G5EG47", "WBGene00010054", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "O44625", "WBGene00004136", "Q9NEX2", "WBGene00013736", "Q95ZS0", "WBGene00006392", "Q9GZI6", "WBGene00006387", "G5EF68", "WBGene00006386", "O45784", "WBGene00006391", "P32085", "WBGene00006542", "O61707", "WBGene00006385", "Q9NEW8", "WBGene00006389", "Q9TYN3", "WBGene00006383", "Q18265", "WBGene00016173", "Q17957", "WBGene00006397", "E9P861", "WBGene00006384", "Q20361", "WBGene00006395", "G5EGM3", "WBGene00006382", "O16991", "WBGene00006648", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "WBGene00006648", "Q95ZS0", "WBGene00006392", "Q9GZI6", "WBGene00006387", "G5EF68", "WBGene00006386", "O45784", "WBGene00006391", "P32085", "WBGene00006542", "O61707", "WBGene00006385", "Q9NEW8", "WBGene00006389", "Q9TYN3", "WBGene00006383", "Q18265", "WBGene00016173", "Q17957", "WBGene00006397", "E9P861", "WBGene00006384", "Q20361", "WBGene00006395", "G5EGM3", "WBGene00006382", "O44625", "WBGene00004136", "Q9NEX2", "WBGene00013736", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "G5EG49", "WBGene00013998", "G5EG47", "WBGene00010054" ] }, "reaction_10509383": { "compartment": "compartment_7660", "id": "reaction_10509383", "reactome": "R-CEL-112429", "name": "Formation of FACT complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509276", "species_10509281" ], "products": [ "species_10509283" ], "modifiers": [], "additional_components": [ "WBGene00001974", "WBGene00018849", "Q9N5R9", "WBGene00018849", "P41848", "WBGene00001974" ] }, "reaction_10509385": { "compartment": "compartment_7660", "id": "reaction_10509385", "reactome": "R-CEL-112430", "name": "Formation of P-TEFb complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509215", "species_10509194" ], "products": [ "species_10509217" ], "modifiers": [], "additional_components": [ "P34424", "WBGene00000508", "P34425", "WBGene00000507", "O17869", "WBGene00009650", "WBGene00000410", "Q9TVL3", "WBGene00000410", "P34424", "WBGene00000508", "P34425", "WBGene00000507", "O17869", "WBGene00009650" ] }, "reaction_10507434": { "compartment": "compartment_7660", "id": "reaction_10507434", "reactome": "R-CEL-75862", "name": "Fall Back to Closed Pre-initiation Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10507424" ], "products": [ "species_10507432" ], "modifiers": [], "additional_components": [ "G5EG49", "WBGene00013998", "G5EG47", "WBGene00010054", "O44625", "WBGene00004136", "Q9NEX2", "WBGene00013736", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q95ZS0", "WBGene00006392", "Q9GZI6", "WBGene00006387", "G5EF68", "WBGene00006386", "O45784", "WBGene00006391", "P32085", "WBGene00006542", "O61707", "WBGene00006385", "Q9NEW8", "WBGene00006389", "Q9TYN3", "WBGene00006383", "Q18265", "WBGene00016173", "Q17957", "WBGene00006397", "E9P861", "WBGene00006384", "Q20361", "WBGene00006395", "G5EGM3", "WBGene00006382", "O16991", "WBGene00006648", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "G5EG49", "WBGene00013998", "G5EG47", "WBGene00010054", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q95ZS0", "WBGene00006392", "Q9GZI6", "WBGene00006387", "G5EF68", "WBGene00006386", "O45784", "WBGene00006391", "P32085", "WBGene00006542", "O61707", "WBGene00006385", "Q9NEW8", "WBGene00006389", "Q9TYN3", "WBGene00006383", "Q18265", "WBGene00016173", "Q17957", "WBGene00006397", "E9P861", "WBGene00006384", "Q20361", "WBGene00006395", "G5EGM3", "WBGene00006382", "O44625", "WBGene00004136", "Q9NEX2", "WBGene00013736", "O16991", "WBGene00006648", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529" ] }, "reaction_10509387": { "compartment": "compartment_7660", "id": "reaction_10509387", "reactome": "R-CEL-112434", "name": "Formation of DSIF complex ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508149", "species_10509232" ], "products": [ "species_10509234" ], "modifiers": [], "additional_components": [ "WBGene00005015", "WBGene00005014", "Q9TZ93", "WBGene00005014", "Q21338", "WBGene00005015" ] }, "reaction_10509389": { "compartment": "compartment_7660", "id": "reaction_10509389", "reactome": "R-CEL-112435", "name": "Formation of Elongin BC complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509293", "species_10509288" ], "products": [ "species_10509295" ], "modifiers": [], "additional_components": [ "WBGene00001235", "WBGene00001236", "Q9BKS1", "WBGene00001236", "G5ECR7", "WBGene00001235" ] }, "reaction_10509391": { "compartment": "compartment_7660", "id": "reaction_10509391", "reactome": "R-CEL-112436", "name": "Formation of Elongin complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509295", "species_10509300" ], "products": [ "species_10509306" ], "modifiers": [], "additional_components": [ "Q9BKS1", "WBGene00001236", "G5ECR7", "WBGene00001235", "WBGene00010990", "Q09413", "WBGene00010990", "Q9BKS1", "WBGene00001236", "G5ECR7", "WBGene00001235" ] }, "reaction_10509395": { "compartment": "compartment_7660", "id": "reaction_10509395", "reactome": "R-CEL-113409", "name": "Abortive termination of early transcription elongation by DSIF:NELF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509360" ], "products": [ "species_10509360" ], "modifiers": [], "additional_components": [ "Q9TZ93", "WBGene00005014", "Q21338", "WBGene00005015", "Q9XUM4", "WBGene00012236", "P16356", "WBGene00000123", "Q19826", "WBGene00017830", "Q9XVH6", "WBGene00012187", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q9U3I0", "WBGene00009078", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q10578", "WBGene00016140", "Q17684", "WBGene00007355", "O02092", "WBGene00018391", "Q9GR61", "WBGene00021347", "Q9N3C9", "WBGene00021845", "Q93338", "WBGene00007971", "Q93594", "WBGene00009141", "O01763", "WBGene00018156", "Q9TZ93", "WBGene00005014", "Q21338", "WBGene00005015", "Q9XUM4", "WBGene00012236", "P16356", "WBGene00000123", "Q19826", "WBGene00017830", "Q9XVH6", "WBGene00012187", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q9U3I0", "WBGene00009078", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q10578", "WBGene00016140", "Q17684", "WBGene00007355", "O02092", "WBGene00018391", "Q9GR61", "WBGene00021347", "Q9N3C9", "WBGene00021845", "Q93338", "WBGene00007971", "Q93594", "WBGene00009141", "O01763", "WBGene00018156" ] }, "reaction_10509397": { "compartment": "compartment_7660", "id": "reaction_10509397", "reactome": "R-CEL-113411", "name": "2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509365" ], "products": [ "species_10509369" ], "modifiers": [], "additional_components": [ "Q9TXQ9", "WBGene00017011", "Q9TVL3", "WBGene00000410", "P34424", "WBGene00000508", "P34425", "WBGene00000507", "O17869", "WBGene00009650", "Q9N5R9", "WBGene00018849", "P41848", "WBGene00001974", "species_110614", "species_29358", "species_29494", "species_29438", "P34703", "WBGene00001259", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q9N554", "WBGene00021281", "Q9TZ93", "WBGene00005014", "Q21338", "WBGene00005015", "H2KYV0", "WBGene00016115", "P52652", "WBGene00012000", "Q9XUM4", "WBGene00012236", "Q09413", "WBGene00010990", "Q9BKS1", "WBGene00001236", "G5ECR7", "WBGene00001235", "G5EBY0", "WBGene00009103", "Q03560", "WBGene00007184", "A5Z2V7", "WBGene00008533", "Q17431", "WBGene00007110", "P90783", "WBGene00008338", "Q9N5U5", "WBGene00018064", "Q19375", "WBGene00008729", "Q9TXQ9", "WBGene00017011", "Q9TVL3", "WBGene00000410", "P34424", "WBGene00000508", "P34425", "WBGene00000507", "O17869", "WBGene00009650", "Q9N5R9", "WBGene00018849", "P41848", "WBGene00001974", "P34703", "WBGene00001259", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q9N554", "WBGene00021281", "Q9TZ93", "WBGene00005014", "Q21338", "WBGene00005015", "H2KYV0", "WBGene00016115", "P52652", "WBGene00012000", "Q9XUM4", "WBGene00012236", "Q09413", "WBGene00010990", "Q9BKS1", "WBGene00001236", "G5ECR7", "WBGene00001235", "G5EBY0", "WBGene00009103", "Q03560", "WBGene00007184", "A5Z2V7", "WBGene00008533", "Q17431", "WBGene00007110", "P90783", "WBGene00008338", "Q9N5U5", "WBGene00018064", "Q19375", "WBGene00008729" ] }, "reaction_10509401": { "compartment": "compartment_7660", "id": "reaction_10509401", "reactome": "R-CEL-113413", "name": "TFIIS-mediated recovery of elongation from arrest", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509365" ], "products": [ "species_10509365" ], "modifiers": [], "additional_components": [ "Q9TXQ9", "WBGene00017011", "Q9TVL3", "WBGene00000410", "P34424", "WBGene00000508", "P34425", "WBGene00000507", "O17869", "WBGene00009650", "Q9N5R9", "WBGene00018849", "P41848", "WBGene00001974", "species_110614", "species_29358", "species_29494", "species_29438", "P34703", "WBGene00001259", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q9N554", "WBGene00021281", "Q9TZ93", "WBGene00005014", "Q21338", "WBGene00005015", "H2KYV0", "WBGene00016115", "P52652", "WBGene00012000", "Q9XUM4", "WBGene00012236", "Q09413", "WBGene00010990", "Q9BKS1", "WBGene00001236", "G5ECR7", "WBGene00001235", "G5EBY0", "WBGene00009103", "Q03560", "WBGene00007184", "A5Z2V7", "WBGene00008533", "Q17431", "WBGene00007110", "P90783", "WBGene00008338", "Q9N5U5", "WBGene00018064", "Q19375", "WBGene00008729", "Q9TXQ9", "WBGene00017011", "Q9TVL3", "WBGene00000410", "P34424", "WBGene00000508", "P34425", "WBGene00000507", "O17869", "WBGene00009650", "Q9N5R9", "WBGene00018849", "P41848", "WBGene00001974", "species_110614", "species_29358", "species_29494", "species_29438", "P34703", "WBGene00001259", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q9N554", "WBGene00021281", "Q9TZ93", "WBGene00005014", "Q21338", "WBGene00005015", "H2KYV0", "WBGene00016115", "P52652", "WBGene00012000", "Q9XUM4", "WBGene00012236", "Q09413", "WBGene00010990", "Q9BKS1", "WBGene00001236", "G5ECR7", "WBGene00001235", "G5EBY0", "WBGene00009103", "Q03560", "WBGene00007184", "A5Z2V7", "WBGene00008533", "Q17431", "WBGene00007110", "P90783", "WBGene00008338", "Q9N5U5", "WBGene00018064", "Q19375", "WBGene00008729" ] }, "reaction_10509371": { "compartment": "compartment_7660", "id": "reaction_10509371", "reactome": "R-CEL-112392", "name": "Resumption of elongation after recovery from pausing", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509369" ], "products": [ "species_10509365" ], "modifiers": [], "additional_components": [ "Q9TXQ9", "WBGene00017011", "Q9TVL3", "WBGene00000410", "P34424", "WBGene00000508", "P34425", "WBGene00000507", "O17869", "WBGene00009650", "Q9N5R9", "WBGene00018849", "P41848", "WBGene00001974", "P34703", "WBGene00001259", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q9N554", "WBGene00021281", "Q9TZ93", "WBGene00005014", "Q21338", "WBGene00005015", "H2KYV0", "WBGene00016115", "P52652", "WBGene00012000", "Q9XUM4", "WBGene00012236", "Q09413", "WBGene00010990", "Q9BKS1", "WBGene00001236", "G5ECR7", "WBGene00001235", "G5EBY0", "WBGene00009103", "Q03560", "WBGene00007184", "A5Z2V7", "WBGene00008533", "Q17431", "WBGene00007110", "P90783", "WBGene00008338", "Q9N5U5", "WBGene00018064", "Q19375", "WBGene00008729", "Q9TXQ9", "WBGene00017011", "Q9TVL3", "WBGene00000410", "P34424", "WBGene00000508", "P34425", "WBGene00000507", "O17869", "WBGene00009650", "Q9N5R9", "WBGene00018849", "P41848", "WBGene00001974", "species_110614", "species_29358", "species_29494", "species_29438", "P34703", "WBGene00001259", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q9N554", "WBGene00021281", "Q9TZ93", "WBGene00005014", "Q21338", "WBGene00005015", "H2KYV0", "WBGene00016115", "P52652", "WBGene00012000", "Q9XUM4", "WBGene00012236", "Q09413", "WBGene00010990", "Q9BKS1", "WBGene00001236", "G5ECR7", "WBGene00001235", "G5EBY0", "WBGene00009103", "Q03560", "WBGene00007184", "A5Z2V7", "WBGene00008533", "Q17431", "WBGene00007110", "P90783", "WBGene00008338", "Q9N5U5", "WBGene00018064", "Q19375", "WBGene00008729" ] }, "reaction_10509403": { "compartment": "compartment_7660", "id": "reaction_10509403", "reactome": "R-CEL-113414", "name": "7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509365" ], "products": [ "species_10509365" ], "modifiers": [], "additional_components": [ "Q9TXQ9", "WBGene00017011", "Q9TVL3", "WBGene00000410", "P34424", "WBGene00000508", "P34425", "WBGene00000507", "O17869", "WBGene00009650", "Q9N5R9", "WBGene00018849", "P41848", "WBGene00001974", "species_110614", "species_29358", "species_29494", "species_29438", "P34703", "WBGene00001259", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q9N554", "WBGene00021281", "Q9TZ93", "WBGene00005014", "Q21338", "WBGene00005015", "H2KYV0", "WBGene00016115", "P52652", "WBGene00012000", "Q9XUM4", "WBGene00012236", "Q09413", "WBGene00010990", "Q9BKS1", "WBGene00001236", "G5ECR7", "WBGene00001235", "G5EBY0", "WBGene00009103", "Q03560", "WBGene00007184", "A5Z2V7", "WBGene00008533", "Q17431", "WBGene00007110", "P90783", "WBGene00008338", "Q9N5U5", "WBGene00018064", "Q19375", "WBGene00008729", "Q9TXQ9", "WBGene00017011", "Q9TVL3", "WBGene00000410", "P34424", "WBGene00000508", "P34425", "WBGene00000507", "O17869", "WBGene00009650", "Q9N5R9", "WBGene00018849", "P41848", "WBGene00001974", "species_110614", "species_29358", "species_29494", "species_29438", "P34703", "WBGene00001259", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q9N554", "WBGene00021281", "Q9TZ93", "WBGene00005014", "Q21338", "WBGene00005015", "H2KYV0", "WBGene00016115", "P52652", "WBGene00012000", "Q9XUM4", "WBGene00012236", "Q09413", "WBGene00010990", "Q9BKS1", "WBGene00001236", "G5ECR7", "WBGene00001235", "G5EBY0", "WBGene00009103", "Q03560", "WBGene00007184", "A5Z2V7", "WBGene00008533", "Q17431", "WBGene00007110", "P90783", "WBGene00008338", "Q9N5U5", "WBGene00018064", "Q19375", "WBGene00008729" ] }, "reaction_10507581": { "compartment": "compartment_7660", "id": "reaction_10507581", "reactome": "R-CEL-75891", "name": "Abortive Initiation After Second Transition", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10507579" ], "products": [ "species_10506316", "species_75897", "species_10504433", "species_10506528" ], "modifiers": [], "additional_components": [ "G5EG49", "WBGene00013998", "G5EG47", "WBGene00010054", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "G5EG49", "WBGene00013998", "G5EG47", "WBGene00010054" ] }, "reaction_10507422": { "compartment": "compartment_7660", "id": "reaction_10507422", "reactome": "R-CEL-75856", "name": "Abortive Initiation Before Second Transition", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10507420" ], "products": [ "species_10506316", "species_10506438", "species_110068", "species_10506516", "species_10506433", "species_10504433", "species_10506528" ], "modifiers": [], "additional_components": [ "G5EG49", "WBGene00013998", "G5EG47", "WBGene00010054", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "O44625", "WBGene00004136", "Q9NEX2", "WBGene00013736", "Q95ZS0", "WBGene00006392", "Q9GZI6", "WBGene00006387", "G5EF68", "WBGene00006386", "O45784", "WBGene00006391", "P32085", "WBGene00006542", "O61707", "WBGene00006385", "Q9NEW8", "WBGene00006389", "Q9TYN3", "WBGene00006383", "Q18265", "WBGene00016173", "Q17957", "WBGene00006397", "E9P861", "WBGene00006384", "Q20361", "WBGene00006395", "G5EGM3", "WBGene00006382", "O16991", "WBGene00006648", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "WBGene00006648", "Q95ZS0", "WBGene00006392", "Q9GZI6", "WBGene00006387", "G5EF68", "WBGene00006386", "O45784", "WBGene00006391", "P32085", "WBGene00006542", "O61707", "WBGene00006385", "Q9NEW8", "WBGene00006389", "Q9TYN3", "WBGene00006383", "Q18265", "WBGene00016173", "Q17957", "WBGene00006397", "E9P861", "WBGene00006384", "Q20361", "WBGene00006395", "G5EGM3", "WBGene00006382", "O44625", "WBGene00004136", "Q9NEX2", "WBGene00013736", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "G5EG49", "WBGene00013998", "G5EG47", "WBGene00010054" ] }, "reaction_10509375": { "compartment": "compartment_7660", "id": "reaction_10509375", "reactome": "R-CEL-112395", "name": "Abortive termination of elongation after arrest", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509365" ], "products": [ "species_10509373" ], "modifiers": [], "additional_components": [ "Q9TXQ9", "WBGene00017011", "Q9TVL3", "WBGene00000410", "P34424", "WBGene00000508", "P34425", "WBGene00000507", "O17869", "WBGene00009650", "Q9N5R9", "WBGene00018849", "P41848", "WBGene00001974", "species_110614", "species_29358", "species_29494", "species_29438", "P34703", "WBGene00001259", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q9N554", "WBGene00021281", "Q9TZ93", "WBGene00005014", "Q21338", "WBGene00005015", "H2KYV0", "WBGene00016115", "P52652", "WBGene00012000", "Q9XUM4", "WBGene00012236", "Q09413", "WBGene00010990", "Q9BKS1", "WBGene00001236", "G5ECR7", "WBGene00001235", "G5EBY0", "WBGene00009103", "Q03560", "WBGene00007184", "A5Z2V7", "WBGene00008533", "Q17431", "WBGene00007110", "P90783", "WBGene00008338", "Q9N5U5", "WBGene00018064", "Q19375", "WBGene00008729", "Q9TXQ9", "WBGene00017011", "Q9TVL3", "WBGene00000410", "P34424", "WBGene00000508", "P34425", "WBGene00000507", "O17869", "WBGene00009650", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q9N5R9", "WBGene00018849", "P41848", "WBGene00001974", "P34703", "WBGene00001259", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q9N554", "WBGene00021281", "Q9TZ93", "WBGene00005014", "Q21338", "WBGene00005015", "H2KYV0", "WBGene00016115", "P52652", "WBGene00012000", "Q9XUM4", "WBGene00012236", "Q09413", "WBGene00010990", "Q9BKS1", "WBGene00001236", "G5ECR7", "WBGene00001235", "G5EBY0", "WBGene00009103", "Q03560", "WBGene00007184", "A5Z2V7", "WBGene00008533", "Q17431", "WBGene00007110", "P90783", "WBGene00008338", "Q9N5U5", "WBGene00018064", "Q19375", "WBGene00008729" ] }, "reaction_10517522": { "compartment": "compartment_984", "id": "reaction_10517522", "reactome": "R-CEL-264695", "name": "cholesterol + phosphatidylcholine (lecithin) => cholesterol ester + 2-lysophosphatidylcholine (lysolecithin)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_171149", "species_194276" ], "products": [ "species_194236", "species_171076" ], "modifiers": [ [ "species_10517519", "catalyst" ] ], "additional_components": [ "WBGene00010872" ] }, "reaction_10516629": { "compartment": "compartment_984", "id": "reaction_10516629", "reactome": "R-CEL-210420", "name": "Ca2+ influx through voltage gated Ca2+ channels", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74112" ], "products": [ "species_74016" ], "modifiers": [ [ "species_10516626", "catalyst" ], [ "species_74126", "inhibitor" ] ], "additional_components": [ "A0A3B1E663", "WBGene00006742", "G5EBI8", "WBGene00017400", "G5EDT2", "WBGene00007670", "O01661", "WBGene00000368", "A0A078BQJ0", "WBGene00021125" ] }, "reaction_10565831": { "compartment": "compartment_12045", "id": "reaction_10565831", "reactome": "R-CEL-8857686", "name": "FITM1, FITM2 bind TAGs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_549167", "species_10565825" ], "products": [ "species_10565829" ], "modifiers": [], "additional_components": [ "WBGene00044094", "Q5CZ37", "WBGene00044094", "species_171126" ] }, "reaction_10565903": { "compartment": "compartment_70101", "id": "reaction_10565903", "reactome": "R-CEL-8862380", "name": "HSD17B13 binds lipid droplets", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10556974", "species_8866926" ], "products": [ "species_10565901" ], "modifiers": [], "additional_components": [ "A5JYX5", "WBGene00000967", "O18030", "WBGene00000968", "Q19843", "WBGene00000992", "Q22392", "WBGene00000982", "species_171126", "species_8876704", "CHEBI:16247", "species_171126", "species_8876704", "CHEBI:16247", "A5JYX5", "WBGene00000967", "O18030", "WBGene00000968", "Q19843", "WBGene00000992", "Q22392", "WBGene00000982" ] }, "reaction_10542689": { "compartment": "compartment_17957", "id": "reaction_10542689", "reactome": "R-CEL-2089971", "name": "Secretion of collagens", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10542497" ], "products": [ "species_10542687", "species_10540972" ], "modifiers": [], "additional_components": [ "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "A9Z1L1", "WBGene00005648", "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689", "Q19368", "WBGene00000702", "Q21437", "WBGene00000659", "Q9N4U2", "WBGene00000647", "O76368", "WBGene00000674", "Q09457", "WBGene00000251", "P17140", "WBGene00002280", "Q09457", "WBGene00000251", "Q9N4U2", "WBGene00000647", "O76368", "WBGene00000674", "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689", "P17140", "WBGene00002280", "Q21437", "WBGene00000659", "Q19368", "WBGene00000702", "G5ECY2", "WBGene00005644", "G5EE40", "WBGene00005642", "G5EFH4", "WBGene00005647", "O17365", "WBGene00005643", "Q18287", "WBGene00016187", "Q19651", "WBGene00005649", "A9Z1L1", "WBGene00005648" ] }, "reaction_10536930": { "compartment": "compartment_17957", "id": "reaction_10536930", "reactome": "R-CEL-1650808", "name": "Prolyl 4-hydroxylase converts collagen prolines to 4-hydroxyprolines", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_10536805", "species_1650779" ], "products": [ "species_1650769", "species_10536918", "species_159751" ], "modifiers": [ [ "species_10536927", "catalyst" ] ], "additional_components": [ "O76368", "WBGene00000674", "Q09457", "WBGene00000251", "Q9N4U2", "WBGene00000647", "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689", "Q17770", "WBGene00003963", "Q17770", "WBGene00003963", "CHEBI:29073", "B1V8J4", "WBGene00012815", "Q17770", "WBGene00003963", "species_113531" ] }, "reaction_10539491": { "compartment": "compartment_12045", "id": "reaction_10539491", "reactome": "R-CEL-1981157", "name": "Glucosylation of collagen propeptide hydroxylysines", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_173594", "species_10539158" ], "products": [ "species_158602", "species_10539488" ], "modifiers": [ [ "species_10538479", "catalyst" ] ], "additional_components": [ "species_113531", "Q20679", "WBGene00002497", "species_113531", "Q20679", "WBGene00002497", "species_113531", "Q20679", "WBGene00002497" ] }, "reaction_10568836": { "compartment": "compartment_17957", "id": "reaction_10568836", "reactome": "R-CEL-8948219", "name": "PLOD3 binds Lysyl hydroxylated collagen propeptides", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10538479", "species_10538808" ], "products": [ "species_10539156" ], "modifiers": [], "additional_components": [ "species_113531", "Q20679", "WBGene00002497", "species_113531", "Q20679", "WBGene00002497" ] }, "reaction_10568838": { "compartment": "compartment_17957", "id": "reaction_10568838", "reactome": "R-CEL-8948222", "name": "PLOD3:Fe2+ dimer:Galactosyl-hydroxylysyl collagen propeptides dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10539158" ], "products": [ "species_10538479", "species_10539149" ], "modifiers": [], "additional_components": [ "species_113531", "Q20679", "WBGene00002497", "species_113531", "Q20679", "WBGene00002497" ] }, "reaction_10568840": { "compartment": "compartment_17957", "id": "reaction_10568840", "reactome": "R-CEL-8948224", "name": "PLOD3:Fe2+ dimer:Glucosyl-galactosyl-hydroxylysyl collagen propeptides dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10539488" ], "products": [ "species_10538479", "species_10539486" ], "modifiers": [], "additional_components": [ "species_113531", "Q20679", "WBGene00002497", "species_113531", "Q20679", "WBGene00002497" ] }, "reaction_10568842": { "compartment": "compartment_17957", "id": "reaction_10568842", "reactome": "R-CEL-8948228", "name": "COLGALT1,COLGALT2 bind Lysyl hydroxylated collagen propeptides", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10538808", "species_10538822" ], "products": [ "species_10538824" ], "modifiers": [], "additional_components": [ "Q18989", "WBGene00008426", "Q18989", "WBGene00008426" ] }, "reaction_10540780": { "compartment": "compartment_984", "id": "reaction_10540780", "reactome": "R-CEL-2002428", "name": "Removal of fibrillar collagen N-propeptides", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10540153" ], "products": [ "species_10540761" ], "modifiers": [ [ "species_10540777", "catalyst" ] ], "additional_components": [ "Q09457", "WBGene00000251", "Q9N4U2", "WBGene00000647", "O76368", "WBGene00000674", "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689", "P17140", "WBGene00002280", "Q21437", "WBGene00000659", "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689", "O76368", "WBGene00000674", "Q09457", "WBGene00000251", "Q9N4U2", "WBGene00000647", "P17140", "WBGene00002280", "Q21437", "WBGene00000659", "Q20176", "WBGene00003555", "O76840", "WBGene00003242" ] }, "reaction_10568844": { "compartment": "compartment_17957", "id": "reaction_10568844", "reactome": "R-CEL-8948231", "name": "COLGALT1,COLGALT2:Galactosyl-hydroxylysyl collagen propeptides dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10539151" ], "products": [ "species_10539149", "species_10538822" ], "modifiers": [], "additional_components": [ "Q18989", "WBGene00008426", "Q18989", "WBGene00008426" ] }, "reaction_10568846": { "compartment": "compartment_17957", "id": "reaction_10568846", "reactome": "R-CEL-8948232", "name": "Lysyl hydroxylated collagen propeptides dissociate from Lysyl hydroxylases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10538810" ], "products": [ "species_10538808", "species_10538481" ], "modifiers": [], "additional_components": [ "Q20679", "WBGene00002497", "species_113531", "Q20679", "WBGene00002497", "species_113531" ] }, "reaction_10568848": { "compartment": "compartment_17957", "id": "reaction_10568848", "reactome": "R-CEL-8948234", "name": "P4HB:4-Hyp collagen propeptides dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10536918" ], "products": [ "species_10536685", "species_10536916" ], "modifiers": [], "additional_components": [ "Q17770", "WBGene00003963", "WBGene00003963" ] }, "reaction_10540785": { "compartment": "compartment_984", "id": "reaction_10540785", "reactome": "R-CEL-2002440", "name": "Removal of fibrillar collagen C-propeptides", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10540761" ], "products": [ "species_10534596" ], "modifiers": [ [ "species_10540775", "catalyst" ] ], "additional_components": [ "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689", "O76368", "WBGene00000674", "Q09457", "WBGene00000251", "Q9N4U2", "WBGene00000647", "P17140", "WBGene00002280", "Q21437", "WBGene00000659", "P17140", "WBGene00002280", "O76368", "WBGene00000674", "Q09457", "WBGene00000251", "Q9N4U2", "WBGene00000647", "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689", "Q21437", "WBGene00000659", "WBGene00003555" ] }, "reaction_10539154": { "compartment": "compartment_17957", "id": "reaction_10539154", "reactome": "R-CEL-1981120", "name": "Galactosylation of collagen propeptide hydroxylysines by procollagen galactosyltransferases 1, 2.", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1981137", "species_10538824" ], "products": [ "species_10539151", "species_158602" ], "modifiers": [ [ "species_10538824", "catalyst" ] ], "additional_components": [ "Q18989", "WBGene00008426", "Q18989", "WBGene00008426", "Q18989", "WBGene00008426" ] }, "reaction_10540787": { "compartment": "compartment_17957", "id": "reaction_10540787", "reactome": "R-CEL-2002460", "name": "P4HB binds Collagen chains", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10536685", "species_10536803" ], "products": [ "species_10536805" ], "modifiers": [], "additional_components": [ "WBGene00003963", "O76368", "WBGene00000674", "Q09457", "WBGene00000251", "Q9N4U2", "WBGene00000647", "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689", "O76368", "WBGene00000674", "Q09457", "WBGene00000251", "Q9N4U2", "WBGene00000647", "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689", "Q17770", "WBGene00003963" ] }, "reaction_10542934": { "compartment": "compartment_17957", "id": "reaction_10542934", "reactome": "R-CEL-2152276", "name": "Secretion of transmembrane collagens", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10540944" ], "products": [ "species_10542932" ], "modifiers": [], "additional_components": [ "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689", "O17641", "WBGene00000751", "Q9N3X9", "WBGene00000689" ] }, "reaction_10539161": { "compartment": "compartment_12045", "id": "reaction_10539161", "reactome": "R-CEL-1981128", "name": "Galactosylation of collagen propeptide hydroxylysines by PLOD3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1981137", "species_10539156" ], "products": [ "species_158602", "species_10539158" ], "modifiers": [ [ "species_10538479", "catalyst" ] ], "additional_components": [ "species_113531", "Q20679", "WBGene00002497", "species_113531", "Q20679", "WBGene00002497", "species_113531", "Q20679", "WBGene00002497" ] }, "reaction_10538460": { "compartment": "compartment_17957", "id": "reaction_10538460", "reactome": "R-CEL-1980233", "name": "Collagen prolyl 3-hydroxylase converts 4-Hyp collagen to 3,4-Hyp collagen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_10538344", "species_1650779" ], "products": [ "species_10538457", "species_1650769", "species_159751" ], "modifiers": [ [ "species_10538344", "catalyst" ] ], "additional_components": [ "CHEBI:29073", "species_113531", "CHEBI:29073", "species_113531", "CHEBI:29073", "species_113531" ] }, "reaction_10538813": { "compartment": "compartment_12045", "id": "reaction_10538813", "reactome": "R-CEL-1981104", "name": "Procollagen lysyl hydroxylases convert collagen lysines to 5-hydroxylysines", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_10538483", "species_1650779" ], "products": [ "species_10538810", "species_1650769", "species_159751" ], "modifiers": [ [ "species_10538481", "catalyst" ] ], "additional_components": [ "Q20679", "WBGene00002497", "species_113531", "Q20679", "WBGene00002497", "species_113531", "Q20679", "WBGene00002497", "species_113531" ] }, "reaction_10510320": { "compartment": "compartment_70101", "id": "reaction_10510320", "reactome": "R-CEL-164423", "name": "PhosphoChREBP (Thr 666) is exported to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10510226" ], "products": [ "species_10510224" ], "modifiers": [], "additional_components": [ "WBGene00003378", "WBGene00003378" ] }, "reaction_10510228": { "compartment": "compartment_7660", "id": "reaction_10510228", "reactome": "R-CEL-163670", "name": "Nuclear transport of pChREBP (Thr 666) protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10510224" ], "products": [ "species_10510226" ], "modifiers": [], "additional_components": [ "WBGene00003378", "WBGene00003378" ] }, "reaction_10572971": { "compartment": "compartment_70101", "id": "reaction_10572971", "reactome": "R-CEL-9661405", "name": "ABCC1 transports BIL from cytosol to extracellular region (blood)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189386" ], "products": [ "species_9661418" ], "modifiers": [ [ "species_10517853", "catalyst" ] ], "additional_components": [ "WBGene00003407" ] }, "reaction_10516833": { "compartment": "compartment_984", "id": "reaction_10516833", "reactome": "R-CEL-210439", "name": "glutamate uptake by astrocytes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_210382" ], "products": [ "species_29404" ], "modifiers": [ [ "species_10516830", "catalyst" ] ], "additional_components": [] }, "reaction_10503235": { "compartment": "compartment_70101", "id": "reaction_10503235", "reactome": "R-CEL-70606", "name": "glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29404", "species_113592", "species_31633" ], "products": [ "species_29372", "species_29370", "species_29472" ], "modifiers": [ [ "species_10503232", "catalyst" ] ], "additional_components": [ "Q95YD1", "WBGene00001602", "Q9U307", "WBGene00001604", "O02225", "WBGene00001607", "Q9XVU2", "WBGene00001606", "P34497", "WBGene00001603" ] }, "reaction_10544113": { "compartment": "compartment_70101", "id": "reaction_10544113", "reactome": "R-CEL-2395879", "name": "NUDT18 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2395883", "species_29356" ], "products": [ "species_2395817", "species_29372" ], "modifiers": [ [ "species_10544108", "catalyst" ] ], "additional_components": [ "WBGene00003578" ] }, "reaction_10544116": { "compartment": "compartment_70101", "id": "reaction_10544116", "reactome": "R-CEL-2395965", "name": "NUDT18 hydrolyses 8-OH-dADP to 8-OH-dAMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2395963", "species_29356" ], "products": [ "species_29372", "species_2395964" ], "modifiers": [ [ "species_10544108", "catalyst" ] ], "additional_components": [ "WBGene00003578" ] }, "reaction_10543958": { "compartment": "compartment_5460", "id": "reaction_10543958", "reactome": "R-CEL-2393954", "name": "Mitochondrial NUDT9 hydrolyses ADP-ribose to R5P and AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2393945", "species_113521" ], "products": [ "species_2393950", "species_159448" ], "modifiers": [ [ "species_10543955", "catalyst" ] ], "additional_components": [ "Q09297", "WBGene00003583", "species_114632" ] }, "reaction_10543948": { "compartment": "compartment_70101", "id": "reaction_10543948", "reactome": "R-CEL-2393939", "name": "Cytosolic NUDT5 hydrolyses ADP-ribose to R5P and AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1131972" ], "products": [ "species_73578", "species_76577" ], "modifiers": [ [ "species_10543945", "catalyst" ] ], "additional_components": [ "species_114632", "O61902", "WBGene00003579" ] }, "reaction_10544111": { "compartment": "compartment_70101", "id": "reaction_10544111", "reactome": "R-CEL-2395873", "name": "NUDT18 hydrolyses 8-oxo-GDP to 8-oxo-GMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_2395880" ], "products": [ "species_29372", "species_2395877" ], "modifiers": [ [ "species_10544108", "catalyst" ] ], "additional_components": [ "WBGene00003578" ] }, "reaction_10529189": { "compartment": "compartment_876", "id": "reaction_10529189", "reactome": "R-CEL-917730", "name": "Cargo Recognition And Sorting", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10529158", "species_10529187" ], "products": [ "species_10529160", "species_10529185" ], "modifiers": [], "additional_components": [ "O76258", "WBGene00015658", "Q8WTK0", "WBGene00021771", "Q17687", "WBGene00015508", "O44158", "WBGene00016990", "Q4R133", "WBGene00044542", "Q9NA26", "WBGene00013598", "Q17796", "WBGene00004101", "O01498", "WBGene00004109", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "P49632", "WBGene00006728", "species_179838", "O76258", "WBGene00015658", "Q8WTK0", "WBGene00021771", "Q17687", "WBGene00015508", "O44158", "WBGene00016990", "Q4R133", "WBGene00044542", "Q9NA26", "WBGene00013598", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "P49632", "WBGene00006728", "species_179838", "Q17796", "WBGene00004101", "O01498", "WBGene00004109" ] }, "reaction_10529181": { "compartment": "compartment_70101", "id": "reaction_10529181", "reactome": "R-CEL-917696", "name": "Cargo Sequestration", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10529177", "species_10529160" ], "products": [ "species_10529179", "species_10529158" ], "modifiers": [], "additional_components": [ "Q9U354", "WBGene00012193", "Q19519", "WBGene00008919", "Q18258", "WBGene00016167", "O76258", "WBGene00015658", "Q8WTK0", "WBGene00021771", "Q17687", "WBGene00015508", "O44158", "WBGene00016990", "Q4R133", "WBGene00044542", "Q9NA26", "WBGene00013598", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "P49632", "WBGene00006728", "species_179838", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "P49632", "WBGene00006728", "species_179838", "Q9U354", "WBGene00012193", "Q19519", "WBGene00008919", "Q18258", "WBGene00016167", "O76258", "WBGene00015658", "Q8WTK0", "WBGene00021771", "Q17687", "WBGene00015508", "O44158", "WBGene00016990", "Q4R133", "WBGene00044542", "Q9NA26", "WBGene00013598" ] }, "reaction_10529183": { "compartment": "compartment_70101", "id": "reaction_10529183", "reactome": "R-CEL-917700", "name": "MVB Vesicle Formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10529179", "species_10529080" ], "products": [ "species_10529177", "species_10529112" ], "modifiers": [], "additional_components": [ "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "P49632", "WBGene00006728", "species_179838", "Q9U354", "WBGene00012193", "Q19519", "WBGene00008919", "Q18258", "WBGene00016167", "Q9GYK4", "WBGene00020866", "Q9BL60", "WBGene00022027", "Q9U2F6", "WBGene00012903", "O02208", "WBGene00007216", "Q22718", "WBGene00011976", "Q18886", "WBGene00016961", "Q21959", "WBGene00020025", "Q9U354", "WBGene00012193", "Q19519", "WBGene00008919", "Q18258", "WBGene00016167", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "P49632", "WBGene00006728", "species_179838", "Q9GYK4", "WBGene00020866", "Q9BL60", "WBGene00022027", "Q9U2F6", "WBGene00012903", "O02208", "WBGene00007216", "Q22718", "WBGene00011976", "Q18886", "WBGene00016961", "Q21959", "WBGene00020025" ] }, "reaction_10518835": { "compartment": "compartment_876", "id": "reaction_10518835", "reactome": "R-CEL-374922", "name": "Noradrenalin synaptic vesicle docking and priming", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10516749", "species_10516777", "species_10516744", "species_10518823", "species_10516631", "species_10516739" ], "products": [ "species_10518825" ], "modifiers": [ [ "species_10518823", "catalyst" ] ], "additional_components": [ "WBGene00006798", "Q21049", "WBGene00006364", "Q22366", "WBGene00006750", "P27715", "WBGene00006752", "Q9N415", "WBGene00006513", "WBGene00022271", "Q94057", "WBGene00044062", "Q95XH1", "WBGene00022077", "G5EBK2", "WBGene00014084", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q19767", "WBGene00004898", "Q9GNP0", "WBGene00000295", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "species_209789", "Q94986", "WBGene00004267", "WBGene00006757", "G5EEN8", "WBGene00006454", "A5PEW5", "WBGene00004364", "G5EEN8", "WBGene00006454", "A5PEW5", "WBGene00004364", "Q94057", "WBGene00044062", "Q95XH1", "WBGene00022077", "G5EBK2", "WBGene00014084", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q19767", "WBGene00004898", "Q9GNP0", "WBGene00000295", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "species_209789", "Q94986", "WBGene00004267", "P34815", "WBGene00006757", "Q9GUM7", "WBGene00022271", "Q21049", "WBGene00006364", "Q22366", "WBGene00006750", "P27715", "WBGene00006752", "Q9N415", "WBGene00006513", "O16000", "WBGene00006798", "Q94057", "WBGene00044062", "Q95XH1", "WBGene00022077", "G5EBK2", "WBGene00014084", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q19767", "WBGene00004898", "Q9GNP0", "WBGene00000295", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "species_209789", "Q94986", "WBGene00004267" ] }, "reaction_10518409": { "compartment": "compartment_374932", "id": "reaction_10518409", "reactome": "R-CEL-372542", "name": "Loading of dopamine into synaptic veiscles", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_159362" ], "products": [ "species_351601" ], "modifiers": [ [ "species_10518406", "catalyst" ] ], "additional_components": [ "WBGene00000295" ] }, "reaction_10518830": { "compartment": "compartment_984", "id": "reaction_10518830", "reactome": "R-CEL-374899", "name": "Release of noradrenaline at the synapse", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10518825" ], "products": [ "species_10518827", "species_10516825", "species_10516777", "species_10516744", "species_10516631", "species_10516823", "species_10516807", "species_374935" ], "modifiers": [ [ "species_10518825", "catalyst" ] ], "additional_components": [ "G5EEN8", "WBGene00006454", "A5PEW5", "WBGene00004364", "Q94057", "WBGene00044062", "Q95XH1", "WBGene00022077", "G5EBK2", "WBGene00014084", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q19767", "WBGene00004898", "Q9GNP0", "WBGene00000295", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "species_209789", "Q94986", "WBGene00004267", "P34815", "WBGene00006757", "Q9GUM7", "WBGene00022271", "Q21049", "WBGene00006364", "Q22366", "WBGene00006750", "P27715", "WBGene00006752", "Q9N415", "WBGene00006513", "O16000", "WBGene00006798", "WBGene00000295", "WBGene00004267", "Q21049", "WBGene00006364", "Q22366", "WBGene00006750", "P27715", "WBGene00006752", "Q9N415", "WBGene00006513", "WBGene00022271", "WBGene00006757", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "G5EEN8", "WBGene00006454", "A5PEW5", "WBGene00004364", "Q94057", "WBGene00044062", "Q95XH1", "WBGene00022077", "G5EBK2", "WBGene00014084", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q19767", "WBGene00004898", "O16000", "WBGene00006798", "G5EEN8", "WBGene00006454", "A5PEW5", "WBGene00004364", "Q94057", "WBGene00044062", "Q95XH1", "WBGene00022077", "G5EBK2", "WBGene00014084", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q19767", "WBGene00004898", "Q9GNP0", "WBGene00000295", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "species_209789", "Q94986", "WBGene00004267", "P34815", "WBGene00006757", "Q9GUM7", "WBGene00022271", "Q21049", "WBGene00006364", "Q22366", "WBGene00006750", "P27715", "WBGene00006752", "Q9N415", "WBGene00006513", "O16000", "WBGene00006798" ] }, "reaction_10551442": { "compartment": "compartment_70101", "id": "reaction_10551442", "reactome": "R-CEL-5336443", "name": "LIN7, CASK and APBA1 bind", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10519883", "species_10519878", "species_10519873" ], "products": [ "species_10519889" ], "modifiers": [], "additional_components": [ "WBGene00002996", "WBGene00002991", "WBGene00002999", "O17583", "WBGene00002999", "P54936", "WBGene00002991", "A5PEX5", "WBGene00002996" ] }, "reaction_10519891": { "compartment": "compartment_70101", "id": "reaction_10519891", "reactome": "R-CEL-380574", "name": "Dopamine synaptic vesicle docking and priming", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10519854", "species_10516749", "species_10519865", "species_10516777", "species_10516744", "species_10516631", "species_10516739" ], "products": [ "species_10519867" ], "modifiers": [ [ "species_10519854", "catalyst" ], [ "species_10519889", "catalyst" ] ], "additional_components": [ "species_351601", "Q94057", "WBGene00044062", "Q95XH1", "WBGene00022077", "G5EBK2", "WBGene00014084", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q19767", "WBGene00004898", "Q9GNP0", "WBGene00000295", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "Q94986", "WBGene00004267", "WBGene00006798", "Q21049", "WBGene00006364", "Q22366", "WBGene00006750", "P27715", "WBGene00006752", "Q9N415", "WBGene00006513", "WBGene00022271", "WBGene00006757", "G5EEN8", "WBGene00006454", "A5PEW5", "WBGene00004364", "G5EEN8", "WBGene00006454", "A5PEW5", "WBGene00004364", "P34815", "WBGene00006757", "Q9GUM7", "WBGene00022271", "Q21049", "WBGene00006364", "Q22366", "WBGene00006750", "P27715", "WBGene00006752", "Q9N415", "WBGene00006513", "O16000", "WBGene00006798", "species_351601", "Q94057", "WBGene00044062", "Q95XH1", "WBGene00022077", "G5EBK2", "WBGene00014084", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q19767", "WBGene00004898", "Q9GNP0", "WBGene00000295", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "Q94986", "WBGene00004267", "species_351601", "Q94057", "WBGene00044062", "Q95XH1", "WBGene00022077", "G5EBK2", "WBGene00014084", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q19767", "WBGene00004898", "Q9GNP0", "WBGene00000295", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "Q94986", "WBGene00004267", "O17583", "WBGene00002999", "P54936", "WBGene00002991", "A5PEX5", "WBGene00002996" ] }, "reaction_10519942": { "compartment": "compartment_984", "id": "reaction_10519942", "reactome": "R-CEL-380869", "name": "Release of docked dopamine loaded synaptic vesicle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10519867" ], "products": [ "species_380873", "species_10518827", "species_10516777", "species_10516825", "species_10519865", "species_10516744", "species_10516823", "species_10516631", "species_10516807" ], "modifiers": [ [ "species_10519867", "catalyst" ] ], "additional_components": [ "G5EEN8", "WBGene00006454", "A5PEW5", "WBGene00004364", "P34815", "WBGene00006757", "Q9GUM7", "WBGene00022271", "Q21049", "WBGene00006364", "Q22366", "WBGene00006750", "P27715", "WBGene00006752", "Q9N415", "WBGene00006513", "O16000", "WBGene00006798", "species_351601", "Q94057", "WBGene00044062", "Q95XH1", "WBGene00022077", "G5EBK2", "WBGene00014084", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q19767", "WBGene00004898", "Q9GNP0", "WBGene00000295", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "Q94986", "WBGene00004267", "WBGene00000295", "Q21049", "WBGene00006364", "Q22366", "WBGene00006750", "P27715", "WBGene00006752", "Q9N415", "WBGene00006513", "WBGene00004267", "WBGene00022271", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "WBGene00006757", "G5EEN8", "WBGene00006454", "A5PEW5", "WBGene00004364", "Q94057", "WBGene00044062", "Q95XH1", "WBGene00022077", "G5EBK2", "WBGene00014084", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q19767", "WBGene00004898", "O16000", "WBGene00006798", "G5EEN8", "WBGene00006454", "A5PEW5", "WBGene00004364", "P34815", "WBGene00006757", "Q9GUM7", "WBGene00022271", "Q21049", "WBGene00006364", "Q22366", "WBGene00006750", "P27715", "WBGene00006752", "Q9N415", "WBGene00006513", "O16000", "WBGene00006798", "species_351601", "Q94057", "WBGene00044062", "Q95XH1", "WBGene00022077", "G5EBK2", "WBGene00014084", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q19767", "WBGene00004898", "Q9GNP0", "WBGene00000295", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "Q94986", "WBGene00004267" ] }, "reaction_10563003": { "compartment": "compartment_161320", "id": "reaction_10563003", "reactome": "R-CEL-6803753", "name": "NAAA hydrolyses NAEs to FAs and ethanolamine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_6803725" ], "products": [ "species_6803745", "species_6803778" ], "modifiers": [ [ "species_10563000", "catalyst" ] ], "additional_components": [ "CHEBI:71466", "species_5693752", "CHEBI:85299", "CHEBI:85263", "CHEBI:71464", "CHEBI:85262", "species_390435", "species_33549", "species_8934421", "CHEBI:28875", "CHEBI:16196", "species_422506", "Q9GUI1", "WBGene00021917" ] }, "reaction_10565443": { "compartment": "compartment_161320", "id": "reaction_10565443", "reactome": "R-CEL-8853686", "name": "MAN2B1 hydrolyses GlcNAc (Man)5 to GlcNAc (Man)3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_8853396" ], "products": [ "species_6799577", "species_6799594" ], "modifiers": [ [ "species_10565440", "catalyst" ] ], "additional_components": [ "Q20829", "WBGene00018877", "species_216785" ] }, "reaction_10565448": { "compartment": "compartment_161320", "id": "reaction_10565448", "reactome": "R-CEL-8853710", "name": "MANBA hydrolyses GlcNAc:Man", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8853719" ], "products": [ "species_1678743", "species_6799594" ], "modifiers": [ [ "species_10565445", "catalyst" ] ], "additional_components": [ "WBGene00007904" ] }, "reaction_10562091": { "compartment": "compartment_161320", "id": "reaction_10562091", "reactome": "R-CEL-6799581", "name": "MAN2B2 hydrolyses GlcNAc (Man)3 to GlcNAc:Man", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6799577", "species_1605715" ], "products": [ "species_6799594", "species_8853719" ], "modifiers": [ [ "species_10562088", "catalyst" ] ], "additional_components": [ "Q20829", "WBGene00018877", "species_216785" ] }, "reaction_10554447": { "compartment": "compartment_7660", "id": "reaction_10554447", "reactome": "R-CEL-5655892", "name": "POLK incorporates dNMP opposite to damaged DNA base", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30555", "species_10554438" ], "products": [ "species_10554444", "species_113541" ], "modifiers": [ [ "species_10554438", "catalyst" ] ], "additional_components": [ "species_266099", "species_114632", "P34409", "WBGene00017696", "Q95Y97", "WBGene00019767", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "O02115", "WBGene00003955", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "Q09615", "WBGene00014066", "A0A0K3AUS7", "WBGene00021344", "species_266099", "species_114632", "P34409", "WBGene00017696", "Q09615", "WBGene00014066", "Q95Y97", "WBGene00019767", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "O02115", "WBGene00003955", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "A0A0K3AUS7", "WBGene00021344", "species_266099", "species_114632", "P34409", "WBGene00017696", "Q95Y97", "WBGene00019767", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "O02115", "WBGene00003955", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "Q09615", "WBGene00014066", "A0A0K3AUS7", "WBGene00021344" ] }, "reaction_10506096": { "compartment": "compartment_70101", "id": "reaction_10506096", "reactome": "R-CEL-73591", "name": "beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_73588" ], "products": [ "species_113528", "species_73590", "species_31633" ], "modifiers": [ [ "species_10506093", "catalyst" ] ], "additional_components": [ "species_216785", "Q19437", "WBGene00017440" ] }, "reaction_10506128": { "compartment": "compartment_70101", "id": "reaction_10506128", "reactome": "R-CEL-73616", "name": "thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_83960", "species_29364" ], "products": [ "species_29366", "species_73541" ], "modifiers": [ [ "species_10506073", "catalyst" ] ], "additional_components": [ "species_73524", "Q18164", "WBGene00016103", "species_113596" ] }, "reaction_10506130": { "compartment": "compartment_70101", "id": "reaction_10506130", "reactome": "R-CEL-73618", "name": "5,6-dihydrothymine + H2O => beta-ureidoisobutyrate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_73541" ], "products": [ "species_73617" ], "modifiers": [ [ "species_10506083", "catalyst" ] ], "additional_components": [ "Q18677", "WBGene00000964", "species_216785" ] }, "reaction_10506132": { "compartment": "compartment_70101", "id": "reaction_10506132", "reactome": "R-CEL-73620", "name": "beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_73617" ], "products": [ "species_113528", "species_73619", "species_31633" ], "modifiers": [ [ "species_10506093", "catalyst" ] ], "additional_components": [ "species_216785", "Q19437", "WBGene00017440" ] }, "reaction_10506086": { "compartment": "compartment_70101", "id": "reaction_10506086", "reactome": "R-CEL-73589", "name": "5,6-dihydrouracil + H2O => beta-ureidopropionate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_73584" ], "products": [ "species_73588" ], "modifiers": [ [ "species_10506083", "catalyst" ] ], "additional_components": [ "Q18677", "WBGene00000964", "species_216785" ] }, "reaction_10506681": { "compartment": "compartment_70101", "id": "reaction_10506681", "reactome": "R-CEL-74376", "name": "(deoxy)uridine + orthophosphate <=> uracil + (deoxy)ribose 1-phosphate (UPP)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29372", "species_500430" ], "products": [ "species_83962", "species_500244" ], "modifiers": [ [ "species_10506676", "catalyst" ] ], "additional_components": [ "CHEBI:16450", "CHEBI:16704", "CHEBI:28542", "species_112016", "Q23588", "WBGene00022817" ] }, "reaction_10506076": { "compartment": "compartment_70101", "id": "reaction_10506076", "reactome": "R-CEL-73585", "name": "uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_83962", "species_29364" ], "products": [ "species_29366", "species_73584" ], "modifiers": [ [ "species_10506073", "catalyst" ] ], "additional_components": [ "species_73524", "Q18164", "WBGene00016103", "species_113596" ] }, "reaction_10508397": { "compartment": "compartment_70101", "id": "reaction_10508397", "reactome": "R-CEL-109449", "name": "(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C3)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_500347" ], "products": [ "species_500346", "species_29372" ], "modifiers": [ [ "species_10508394", "catalyst" ] ], "additional_components": [ "species_109395", "CHEBI:15918", "species_109366", "species_500742", "species_109402", "CHEBI:15698", "CHEBI:16450", "CHEBI:16704", "species_83928", "CHEBI:17562", "species_114632", "Q09315", "WBGene00017775", "Q95ZJ9", "WBGene00017775" ] }, "reaction_10506641": { "compartment": "compartment_70101", "id": "reaction_10506641", "reactome": "R-CEL-74242", "name": "(deoxy)inosine + orthophosphate <=> hypoxanthine + (deoxy)ribose 1-phosphate (NP)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29372", "species_500172" ], "products": [ "species_113599", "species_500244" ], "modifiers": [ [ "species_10506638", "catalyst" ] ], "additional_components": [ "CHEBI:28997", "species_83927", "CHEBI:28542", "species_112016", "U4PSA1", "WBGene00019298" ] }, "reaction_10544722": { "compartment": "compartment_70101", "id": "reaction_10544722", "reactome": "R-CEL-2509838", "name": "ITPA hydrolyses dITP to dIMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2509835", "species_29356" ], "products": [ "species_111294", "species_109330" ], "modifiers": [ [ "species_10544713", "catalyst" ], [ "species_29926", "catalyst" ] ], "additional_components": [ "Q9GYG4", "WBGene00001823" ] }, "reaction_10506661": { "compartment": "compartment_70101", "id": "reaction_10506661", "reactome": "R-CEL-74248", "name": "(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_500120", "species_29356" ], "products": [ "species_29372", "species_500118" ], "modifiers": [ [ "species_10506658", "catalyst" ] ], "additional_components": [ "species_29602", "species_109330", "species_113578", "CHEBI:16192", "CHEBI:17172", "CHEBI:28997", "species_83927", "CHEBI:16750", "Q95X21", "WBGene00022201", "species_114632" ] }, "reaction_10506663": { "compartment": "compartment_70101", "id": "reaction_10506663", "reactome": "R-CEL-74249", "name": "(deoxy)guanosine + orthophosphate <=> guanine + (deoxy)ribose 1-phosphate (NP)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29372", "species_500245" ], "products": [ "species_83956", "species_500244" ], "modifiers": [ [ "species_10506638", "catalyst" ] ], "additional_components": [ "CHEBI:17172", "CHEBI:16750", "CHEBI:28542", "species_112016", "U4PSA1", "WBGene00019298" ] }, "reaction_10506665": { "compartment": "compartment_70101", "id": "reaction_10506665", "reactome": "R-CEL-74258", "name": "Xanthine + H2O + O2 => Urate + H2O2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_29368", "species_30064" ], "products": [ "species_30034", "species_29408" ], "modifiers": [ [ "species_10506648", "catalyst" ] ], "additional_components": [ "O17892", "WBGene00010083", "CHEBI:44074", "species_113596" ] }, "reaction_10506651": { "compartment": "compartment_70101", "id": "reaction_10506651", "reactome": "R-CEL-74247", "name": "Hypoxanthine + H2O + O2 => Xanthine + H2O2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113599", "species_29356", "species_29368" ], "products": [ "species_29408", "species_30064" ], "modifiers": [ [ "species_10506648", "catalyst" ] ], "additional_components": [ "O17892", "WBGene00010083", "CHEBI:44074", "species_113596" ] }, "reaction_10544716": { "compartment": "compartment_70101", "id": "reaction_10544716", "reactome": "R-CEL-2509827", "name": "ITPA hydrolyses ITP to IMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_2509836" ], "products": [ "species_111294", "species_29602" ], "modifiers": [ [ "species_10544713", "catalyst" ], [ "species_29926", "catalyst" ] ], "additional_components": [ "Q9GYG4", "WBGene00001823" ] }, "reaction_10544719": { "compartment": "compartment_70101", "id": "reaction_10544719", "reactome": "R-CEL-2509831", "name": "ITPA hydrolyses XTP to XMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2509848", "species_29356" ], "products": [ "species_111294", "species_111584" ], "modifiers": [ [ "species_10544713", "catalyst" ], [ "species_29926", "catalyst" ] ], "additional_components": [ "Q9GYG4", "WBGene00001823" ] }, "reaction_10566331": { "compartment": "compartment_7660", "id": "reaction_10566331", "reactome": "R-CEL-8866601", "name": "SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_8866574" ], "products": [ "species_8866608", "species_8866567" ], "modifiers": [ [ "species_10566328", "catalyst" ], [ "species_29892", "catalyst" ] ], "additional_components": [ "Q09374", "WBGene00022673", "species_216785" ] }, "reaction_10565105": { "compartment": "compartment_17963", "id": "reaction_10565105", "reactome": "R-CEL-8851234", "name": "NTPDase4 hydrolyzes nucleoside triphosphates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2022884", "species_8851233" ], "products": [ "species_8851224", "species_8851226" ], "modifiers": [ [ "species_10565099", "catalyst" ] ], "additional_components": [ "species_110614", "species_29494", "species_29438", "species_30187", "species_110094", "species_158602", "species_29420", "CHEBI:18075", "species_74016", "Q18411", "WBGene00016380", "Q21815", "WBGene00003254" ] }, "reaction_10565122": { "compartment": "compartment_984", "id": "reaction_10565122", "reactome": "R-CEL-8851396", "name": "NTPDase6 hydrolyzes nucleoside diphosphates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_8851462" ], "products": [ "species_109277", "species_8851461" ], "modifiers": [ [ "species_10565119", "catalyst" ] ], "additional_components": [ "CHEBI:17808", "species_158602", "species_29420", "species_110094", "species_109402", "species_29602", "species_109395", "species_113578", "species_114632", "species_74016", "Q9XU84", "WBGene00010697" ] }, "reaction_10565129": { "compartment": "compartment_528865", "id": "reaction_10565129", "reactome": "R-CEL-8851494", "name": "NTPDase7 hydrolyzes nucleoside triphosphates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8851517", "species_8851509" ], "products": [ "species_8851513", "species_8851518" ], "modifiers": [ [ "species_10565126", "catalyst" ] ], "additional_components": [ "species_29494", "species_29438", "species_110614", "species_110094", "species_158602", "species_29420", "Q21815", "WBGene00003254", "species_74016" ] }, "reaction_10565115": { "compartment": "compartment_984", "id": "reaction_10565115", "reactome": "R-CEL-8851356", "name": "NTPDase5 hydrolyzes nucleoside diphosphates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_8936165" ], "products": [ "species_8851369", "species_109277" ], "modifiers": [ [ "species_10565112", "catalyst" ] ], "additional_components": [ "species_113582", "species_158602", "species_29420", "species_110094", "species_109402", "species_109395", "species_113578", "species_76577", "species_114632", "species_74016", "Q9XU84", "WBGene00010697" ] }, "reaction_10565102": { "compartment": "compartment_17963", "id": "reaction_10565102", "reactome": "R-CEL-8851225", "name": "NTPDase4 hydrolyzes nucleoside diphosphates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8851224", "species_2022884" ], "products": [ "species_8851226", "species_8851227" ], "modifiers": [ [ "species_10565099", "catalyst" ] ], "additional_components": [ "species_110094", "species_158602", "species_29420", "CHEBI:18075", "species_113578", "species_109366", "species_109402", "species_109395", "species_74016", "Q18411", "WBGene00016380", "Q21815", "WBGene00003254" ] }, "reaction_10506608": { "compartment": "compartment_70101", "id": "reaction_10506608", "reactome": "R-CEL-74213", "name": "Adenine + PRPP => AMP + PPi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73566", "species_83951" ], "products": [ "species_111294", "species_76577" ], "modifiers": [ [ "species_10506605", "catalyst" ] ], "additional_components": [ "P91455", "WBGene00020557" ] }, "reaction_10542967": { "compartment": "compartment_70101", "id": "reaction_10542967", "reactome": "R-CEL-2161187", "name": "N6-methyl-AMP + H2O => IMP + methylamine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_2161190" ], "products": [ "species_2161177", "species_29602" ], "modifiers": [ [ "species_10542964", "catalyst" ] ], "additional_components": [ "Q8IG39", "WBGene00016632", "species_216785" ] }, "reaction_10506631": { "compartment": "compartment_70101", "id": "reaction_10506631", "reactome": "R-CEL-74241", "name": "(2'-deoxy)adenosine + H2O => (2'-deoxy)inosine + NH4+ (ADA)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_500173" ], "products": [ "species_500172", "species_31633" ], "modifiers": [ [ "species_10506628", "catalyst" ] ], "additional_components": [ "species_83909", "CHEBI:17256", "CHEBI:28997", "species_83927", "WBGene00015551" ] }, "reaction_10527223": { "compartment": "compartment_70101", "id": "reaction_10527223", "reactome": "R-CEL-514604", "name": "GMP + NADPH + H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_113578", "species_29364" ], "products": [ "species_29366", "species_29602", "species_31633" ], "modifiers": [ [ "species_10527220", "catalyst" ] ], "additional_components": [ "O16294", "WBGene00017984" ] }, "reaction_10508120": { "compartment": "compartment_70101", "id": "reaction_10508120", "reactome": "R-CEL-76590", "name": "AMP + H2O => IMP + NH4+ (AMPD)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_76577" ], "products": [ "species_29602", "species_31633" ], "modifiers": [ [ "species_10508117", "catalyst" ] ], "additional_components": [ "A0A2C9C377", "WBGene00016415" ] }, "reaction_10506618": { "compartment": "compartment_70101", "id": "reaction_10506618", "reactome": "R-CEL-74215", "name": "guanine or hypoxanthine + PRPP => GMP or IMP + PPi (HPRT1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73566", "species_500259" ], "products": [ "species_111294", "species_500260" ], "modifiers": [ [ "species_10506615", "catalyst" ] ], "additional_components": [ "species_83956", "species_113599", "species_29602", "species_113578", "Q9NF11", "WBGene00013690", "species_114632" ] }, "reaction_10508442": { "compartment": "compartment_70101", "id": "reaction_10508442", "reactome": "R-CEL-109624", "name": "(2'-deoxy)adenosine + ATP => (d)AMP + ADP (ADK)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_500173", "species_113592" ], "products": [ "species_500088", "species_29370" ], "modifiers": [ [ "species_10508439", "catalyst" ] ], "additional_components": [ "species_83909", "CHEBI:17256", "species_76577", "species_109386", "Q93934", "WBGene00011128", "species_114632" ] }, "reaction_10508640": { "compartment": "compartment_70101", "id": "reaction_10508640", "reactome": "R-CEL-110138", "name": "AK5,7,8,9 phosphorylates (d)NMPs to (d)NDPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6788778", "species_113592" ], "products": [ "species_29370", "species_6788782" ], "modifiers": [ [ "species_10508635", "catalyst" ] ], "additional_components": [ "species_76577", "species_109395", "CHEBI:15918", "species_109386", "species_113582", "CHEBI:28846", "CHEBI:16174", "species_110094", "Q20140", "WBGene00009531" ] }, "reaction_10508896": { "compartment": "compartment_70101", "id": "reaction_10508896", "reactome": "R-CEL-111746", "name": "glutaredoxin (oxidized) + glutathione (reduced) => glutaredoxin (reduced) + glutathione (oxidized)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29450", "species_10508874" ], "products": [ "species_10508871", "species_111745" ], "modifiers": [ [ "species_10508874", "catalyst" ] ], "additional_components": [ "WBGene00021331", "WBGene00021331", "WBGene00021331" ] }, "reaction_10506017": { "compartment": "compartment_70101", "id": "reaction_10506017", "reactome": "R-CEL-73548", "name": "(d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP (CMPK1)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_500009", "species_113592" ], "products": [ "species_29370", "species_500006" ], "modifiers": [ [ "species_10506014", "catalyst" ] ], "additional_components": [ "species_109395", "CHEBI:15918", "species_109402", "species_158602", "CHEBI:28846", "species_110094", "Q20230", "WBGene00009575" ] }, "reaction_10508642": { "compartment": "compartment_70101", "id": "reaction_10508642", "reactome": "R-CEL-110141", "name": "(d)ADP + ADP <=> (d)AMP + ATP (AK1)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29370", "species_500087" ], "products": [ "species_500088", "species_113592" ], "modifiers": [ [ "species_10506620", "catalyst" ] ], "additional_components": [ "species_113582", "CHEBI:16174", "species_76577", "species_109386", "Q20140", "WBGene00009531" ] }, "reaction_10508899": { "compartment": "compartment_70101", "id": "reaction_10508899", "reactome": "R-CEL-111751", "name": "RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8866401", "species_10506160" ], "products": [ "species_10506158", "species_29356", "species_8866399" ], "modifiers": [ [ "species_10508890", "catalyst" ], [ "species_113592", "catalyst" ], [ "species_110644", "inhibitor" ] ], "additional_components": [ "WBGene00015062", "WBGene00015062", "Q03604", "WBGene00004391", "P42170", "WBGene00004392", "species_912516" ] }, "reaction_10563109": { "compartment": "compartment_70101", "id": "reaction_10563109", "reactome": "R-CEL-6806877", "name": "NME1:NME3 heterohexamer, NME2P1 phosphorylate NDPs to NTPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_6806885" ], "products": [ "species_29370", "species_6806881" ], "modifiers": [ [ "species_10563106", "catalyst" ] ], "additional_components": [ "Q93576", "WBGene00009119", "Q7KX00", "WBGene00021692" ] }, "reaction_10526887": { "compartment": "compartment_70101", "id": "reaction_10526887", "reactome": "R-CEL-482619", "name": "(d)NDP + ATP <=> (d)NTP + ADP (NME1,2,3)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_482627" ], "products": [ "species_29370", "species_482625" ], "modifiers": [ [ "species_10526884", "catalyst" ] ], "additional_components": [ "species_158602", "CHEBI:28846", "CHEBI:16174", "species_29420", "CHEBI:28850", "CHEBI:28862", "CHEBI:18075", "species_110094", "species_29892", "species_110644", "species_30185", "species_29494", "species_30187", "species_110614", "species_500739", "species_29438", "Q93576", "WBGene00009119", "Q7KX00", "WBGene00021692" ] }, "reaction_10506152": { "compartment": "compartment_70101", "id": "reaction_10506152", "reactome": "R-CEL-73635", "name": "dUMP or TMP + ATP <=> dUDP or TDP + ADP [DTYMK]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_499997", "species_113592" ], "products": [ "species_29370", "species_499999" ], "modifiers": [ [ "species_10506149", "catalyst" ] ], "additional_components": [ "species_500742", "species_109366", "CHEBI:28850", "CHEBI:18075", "Q22018", "WBGene00011272" ] }, "reaction_10508650": { "compartment": "compartment_70101", "id": "reaction_10508650", "reactome": "R-CEL-110144", "name": "ADP + ADP <=> AMP + ATP [AK2]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29370" ], "products": [ "species_113592", "species_76577" ], "modifiers": [ [ "species_10508647", "catalyst" ] ], "additional_components": [ "WBGene00002879" ] }, "reaction_10508908": { "compartment": "compartment_70101", "id": "reaction_10508908", "reactome": "R-CEL-111804", "name": "RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8866401", "species_10506160" ], "products": [ "species_10506158", "species_29356", "species_8866399" ], "modifiers": [ [ "species_10508905", "catalyst" ], [ "species_113592", "catalyst" ], [ "species_110644", "inhibitor" ] ], "additional_components": [ "WBGene00015062", "WBGene00015062", "Q03604", "WBGene00004391", "P42170", "WBGene00004392", "species_912516" ] }, "reaction_10527086": { "compartment": "compartment_5460", "id": "reaction_10527086", "reactome": "R-CEL-482804", "name": "(d)NDP + ATP <=> (d)NTP + ADP (NME4)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113593", "species_482803" ], "products": [ "species_113581", "species_482807" ], "modifiers": [ [ "species_10527083", "catalyst" ] ], "additional_components": [ "CHEBI:18075", "species_29420", "CHEBI:28850", "CHEBI:28862", "species_158602", "CHEBI:16174", "CHEBI:28846", "species_110094", "species_110614", "species_29438", "species_500739", "species_29892", "species_29494", "species_110644", "species_30185", "species_30187", "Q7KX00", "WBGene00021692", "Q93576", "WBGene00009119" ] }, "reaction_10506180": { "compartment": "compartment_70101", "id": "reaction_10506180", "reactome": "R-CEL-73647", "name": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_29494", "species_29472" ], "products": [ "species_29372", "species_29404", "species_29370", "species_110614" ], "modifiers": [ [ "species_10506177", "catalyst" ] ], "additional_components": [ "G5EC98", "WBGene00012316" ] }, "reaction_10506116": { "compartment": "compartment_70101", "id": "reaction_10506116", "reactome": "R-CEL-73605", "name": "dUMP + N5,N10-methylene tetrahydrofolate => TMP + dihydrofolate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111355", "species_109382" ], "products": [ "species_109366", "species_73604" ], "modifiers": [ [ "species_10506113", "catalyst" ] ], "additional_components": [ "species_114632", "Q9N588", "WBGene00022455" ] }, "reaction_10527109": { "compartment": "compartment_70101", "id": "reaction_10527109", "reactome": "R-CEL-504054", "name": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_29494", "species_29472" ], "products": [ "species_29372", "species_29404", "species_29370", "species_110614" ], "modifiers": [ [ "species_10527106", "catalyst" ] ], "additional_components": [ "G5EC98", "WBGene00012316" ] }, "reaction_10566276": { "compartment": "compartment_70101", "id": "reaction_10566276", "reactome": "R-CEL-8866405", "name": "RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508871", "species_8866401" ], "products": [ "species_29356", "species_10508874", "species_8866399" ], "modifiers": [ [ "species_10508905", "catalyst" ], [ "species_113592", "catalyst" ], [ "species_110644", "inhibitor" ] ], "additional_components": [ "WBGene00021331", "WBGene00021331", "Q03604", "WBGene00004391", "P42170", "WBGene00004392", "species_912516" ] }, "reaction_10558343": { "compartment": "compartment_7660", "id": "reaction_10558343", "reactome": "R-CEL-6788810", "name": "AK6 phosphorylates (d)NMPs to (d)NDPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_6788813" ], "products": [ "species_113582", "species_6788807" ], "modifiers": [ [ "species_10558340", "catalyst" ] ], "additional_components": [ "CHEBI:15918", "species_109395", "species_76577", "species_109386", "species_110094", "CHEBI:16174", "CHEBI:28846", "species_113582", "WBGene00008458" ] }, "reaction_10506190": { "compartment": "compartment_7660", "id": "reaction_10506190", "reactome": "R-CEL-73666", "name": "dUTP + H2O => dUMP + pyrophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_500739" ], "products": [ "species_113541", "species_500742" ], "modifiers": [ [ "species_10506187", "catalyst" ] ], "additional_components": [ "G5EET2", "WBGene00010609" ] }, "reaction_10508631": { "compartment": "compartment_70101", "id": "reaction_10508631", "reactome": "R-CEL-110133", "name": "(d)GDP + ADP <=> (d)GMP + ATP (GUK1)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29370", "species_500077" ], "products": [ "species_113592", "species_500071" ], "modifiers": [ [ "species_10506329", "catalyst" ] ], "additional_components": [ "species_29420", "CHEBI:28862", "species_113578", "CHEBI:16192", "WBGene00020190" ] }, "reaction_10508893": { "compartment": "compartment_70101", "id": "reaction_10508893", "reactome": "R-CEL-111742", "name": "RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508871", "species_8866401" ], "products": [ "species_29356", "species_10508874", "species_8866399" ], "modifiers": [ [ "species_10508890", "catalyst" ], [ "species_113592", "catalyst" ], [ "species_110644", "inhibitor" ] ], "additional_components": [ "WBGene00021331", "WBGene00021331", "Q03604", "WBGene00004391", "P42170", "WBGene00004392", "species_912516" ] }, "reaction_10508638": { "compartment": "compartment_70101", "id": "reaction_10508638", "reactome": "R-CEL-110137", "name": "(d)ADP or (d)CDP + ADP <=> (d)AMP or (d)CMP + ATP", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29370", "species_6788782" ], "products": [ "species_6788778", "species_113592" ], "modifiers": [ [ "species_10508635", "catalyst" ] ], "additional_components": [ "species_113582", "CHEBI:28846", "CHEBI:16174", "species_110094", "species_76577", "species_109395", "CHEBI:15918", "species_109386", "Q20140", "WBGene00009531" ] }, "reaction_10542971": { "compartment": "compartment_70101", "id": "reaction_10542971", "reactome": "R-CEL-2161500", "name": "abacavir [extracellular] => abacavir [cytosol]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2161525" ], "products": [ "species_2161185" ], "modifiers": [ [ "species_10518788", "catalyst" ] ], "additional_components": [ "WBGene00003987" ] }, "reaction_10510416": { "compartment": "compartment_5460", "id": "reaction_10510416", "reactome": "R-CEL-164834", "name": "Enzyme-bound ATP is released", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10510410", "species_163953" ], "products": [ "species_113529", "species_113593", "species_10510406" ], "modifiers": [ [ "species_10510410", "catalyst" ] ], "additional_components": [ "O16314", "WBGene00015460", "Q18803", "WBGene00000210", "Q17763", "WBGene00007385", "Q19126", "WBGene00000207", "Q9BKS0", "WBGene00022336", "Q21732", "WBGene00011015", "O16517", "WBGene00020275", "Q22021", "WBGene00011273", "Q09544", "WBGene00019061", "Q9XXK1", "WBGene00010419", "O16298", "WBGene00017982", "P46561", "WBGene00000229", "Q95XJ0", "WBGene00022089", "Q7JNG1", "WBGene00000230", "species_29358", "O16314", "WBGene00015460", "Q18803", "WBGene00000210", "Q17763", "WBGene00007385", "Q19126", "WBGene00000207", "Q9BKS0", "WBGene00022336", "Q21732", "WBGene00011015", "O16517", "WBGene00020275", "Q22021", "WBGene00011273", "Q09544", "WBGene00019061", "Q9XXK1", "WBGene00010419", "O16298", "WBGene00017982", "P46561", "WBGene00000229", "Q95XJ0", "WBGene00022089", "Q7JNG1", "WBGene00000230", "O16314", "WBGene00015460", "Q18803", "WBGene00000210", "Q17763", "WBGene00007385", "Q19126", "WBGene00000207", "Q9BKS0", "WBGene00022336", "Q21732", "WBGene00011015", "O16517", "WBGene00020275", "Q22021", "WBGene00011273", "Q09544", "WBGene00019061", "Q9XXK1", "WBGene00010419", "O16298", "WBGene00017982", "P46561", "WBGene00000229", "Q95XJ0", "WBGene00022089", "Q7JNG1", "WBGene00000230", "species_29358" ] }, "reaction_10510418": { "compartment": "compartment_5460", "id": "reaction_10510418", "reactome": "R-CEL-164840", "name": "ADP and Pi bind to ATPase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113548", "species_113581", "species_10510406" ], "products": [ "species_10510408" ], "modifiers": [], "additional_components": [ "O16314", "WBGene00015460", "Q18803", "WBGene00000210", "Q17763", "WBGene00007385", "Q19126", "WBGene00000207", "Q9BKS0", "WBGene00022336", "Q21732", "WBGene00011015", "O16517", "WBGene00020275", "Q22021", "WBGene00011273", "Q09544", "WBGene00019061", "Q9XXK1", "WBGene00010419", "O16298", "WBGene00017982", "P46561", "WBGene00000229", "Q95XJ0", "WBGene00022089", "Q7JNG1", "WBGene00000230", "O16314", "WBGene00015460", "Q18803", "WBGene00000210", "Q17763", "WBGene00007385", "Q19126", "WBGene00000207", "Q9BKS0", "WBGene00022336", "Q21732", "WBGene00011015", "O16517", "WBGene00020275", "Q22021", "WBGene00011273", "Q09544", "WBGene00019061", "Q9XXK1", "WBGene00010419", "O16298", "WBGene00017982", "P46561", "WBGene00000229", "Q95XJ0", "WBGene00022089", "Q7JNG1", "WBGene00000230", "species_113582", "species_29372" ] }, "reaction_10510413": { "compartment": "compartment_5460", "id": "reaction_10510413", "reactome": "R-CEL-164832", "name": "ATPase synthesizes ATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10510408" ], "products": [ "species_10510410", "species_113521" ], "modifiers": [ [ "species_10510408", "catalyst" ] ], "additional_components": [ "O16314", "WBGene00015460", "Q18803", "WBGene00000210", "Q17763", "WBGene00007385", "Q19126", "WBGene00000207", "Q9BKS0", "WBGene00022336", "Q21732", "WBGene00011015", "O16517", "WBGene00020275", "Q22021", "WBGene00011273", "Q09544", "WBGene00019061", "Q9XXK1", "WBGene00010419", "O16298", "WBGene00017982", "P46561", "WBGene00000229", "Q95XJ0", "WBGene00022089", "Q7JNG1", "WBGene00000230", "species_113582", "species_29372", "O16314", "WBGene00015460", "Q18803", "WBGene00000210", "Q17763", "WBGene00007385", "Q19126", "WBGene00000207", "Q9BKS0", "WBGene00022336", "Q21732", "WBGene00011015", "O16517", "WBGene00020275", "Q22021", "WBGene00011273", "Q09544", "WBGene00019061", "Q9XXK1", "WBGene00010419", "O16298", "WBGene00017982", "P46561", "WBGene00000229", "Q95XJ0", "WBGene00022089", "Q7JNG1", "WBGene00000230", "species_29358", "O16314", "WBGene00015460", "Q18803", "WBGene00000210", "Q17763", "WBGene00007385", "Q19126", "WBGene00000207", "Q9BKS0", "WBGene00022336", "Q21732", "WBGene00011015", "O16517", "WBGene00020275", "Q22021", "WBGene00011273", "Q09544", "WBGene00019061", "Q9XXK1", "WBGene00010419", "O16298", "WBGene00017982", "P46561", "WBGene00000229", "Q95XJ0", "WBGene00022089", "Q7JNG1", "WBGene00000230", "species_113582", "species_29372" ] }, "reaction_10546133": { "compartment": "compartment_5460", "id": "reaction_10546133", "reactome": "R-CEL-2995334", "name": "COX15 transforms heme O to heme A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2995328" ], "products": [ "species_2995348" ], "modifiers": [ [ "species_10546130", "catalyst" ] ], "additional_components": [ "WBGene00011526" ] }, "reaction_10529229": { "compartment": "compartment_876", "id": "reaction_10529229", "reactome": "R-CEL-917979", "name": "ABCG2 tetramer transports heme from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_71185" ], "products": [ "species_29372", "species_917877", "species_29370" ], "modifiers": [ [ "species_10529226", "catalyst" ] ], "additional_components": [ "D7SFK1", "WBGene00006522" ] }, "reaction_10546125": { "compartment": "compartment_5460", "id": "reaction_10546125", "reactome": "R-CEL-2995330", "name": "COX10 transforms heme to heme O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189444", "species_2162257", "species_113521" ], "products": [ "species_2995328", "species_159450" ], "modifiers": [ [ "species_10546122", "catalyst" ] ], "additional_components": [ "WBGene00012895" ] }, "reaction_10512862": { "compartment": "compartment_5460", "id": "reaction_10512862", "reactome": "R-CEL-189465", "name": "FECH binds Fe2+ to PRIN9 to form heme", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189487", "species_113531" ], "products": [ "species_113529", "species_189444" ], "modifiers": [ [ "species_10512859", "catalyst" ], [ "species_391232", "inhibitor" ] ], "additional_components": [ "G5EBW5", "WBGene00010645" ] }, "reaction_10572969": { "compartment": "compartment_70101", "id": "reaction_10572969", "reactome": "R-CEL-9661397", "name": "SLCO1B1 transports BIL from extracellular region (blood) to cytosol (hepatocyte)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9661418" ], "products": [ "species_189386" ], "modifiers": [ [ "species_10528178", "catalyst" ] ], "additional_components": [ "Q95ZT3", "WBGene00018568", "O62421", "WBGene00018568", "Q20538", "WBGene00018568", "Q93550", "WBGene00018568" ] }, "reaction_10573000": { "compartment": "compartment_70101", "id": "reaction_10573000", "reactome": "R-CEL-9661799", "name": "SLCO1B3 transports BIL from extracellular region (blood) to cytosol (hepatocyte)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9661418" ], "products": [ "species_189386" ], "modifiers": [ [ "species_10572997", "catalyst" ] ], "additional_components": [ "Q93550", "WBGene00018568", "Q95ZT3", "WBGene00018568", "O62421", "WBGene00018568", "Q20538", "WBGene00018568" ] }, "reaction_10572987": { "compartment": "compartment_876", "id": "reaction_10572987", "reactome": "R-CEL-9661723", "name": "SLCO2B1-3 transports BIL from extracellular region (blood) to cytosol (hepatocyte)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9661418" ], "products": [ "species_189386" ], "modifiers": [ [ "species_10572984", "catalyst" ] ], "additional_components": [ "O62421", "WBGene00018568", "Q20538", "WBGene00018568", "Q93550", "WBGene00018568", "Q95ZT3", "WBGene00018568" ] }, "reaction_10573004": { "compartment": "compartment_70101", "id": "reaction_10573004", "reactome": "R-CEL-9663492", "name": "BIL dissociates from GSTA1, FABP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10573002" ], "products": [ "species_189386", "species_10551347" ], "modifiers": [], "additional_components": [ "O02324", "WBGene00002260", "O01812", "WBGene00002258", "O01814", "WBGene00002257", "O02323", "WBGene00002259", "species_189386", "O02324", "WBGene00002260", "O01812", "WBGene00002258", "O01814", "WBGene00002257", "O02323", "WBGene00002259" ] }, "reaction_10573006": { "compartment": "compartment_70101", "id": "reaction_10573006", "reactome": "R-CEL-9663511", "name": "BIL binds GSTA1, FABP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189386", "species_10551347" ], "products": [ "species_10573002" ], "modifiers": [], "additional_components": [ "O02324", "WBGene00002260", "O01812", "WBGene00002258", "O01814", "WBGene00002257", "O02323", "WBGene00002259", "O02324", "WBGene00002260", "O01812", "WBGene00002258", "O01814", "WBGene00002257", "O02323", "WBGene00002259", "species_189386" ] }, "reaction_10572974": { "compartment": "compartment_70101", "id": "reaction_10572974", "reactome": "R-CEL-9661417", "name": "ABCG2 tetramer transports BMG,BDG from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_5679042" ], "products": [ "species_29372", "species_5679034", "species_29370" ], "modifiers": [ [ "species_10529226", "catalyst" ] ], "additional_components": [ "CHEBI:18392", "CHEBI:16427", "CHEBI:16427", "CHEBI:18392", "D7SFK1", "WBGene00006522" ] }, "reaction_10535157": { "compartment": "compartment_70101", "id": "reaction_10535157", "reactome": "R-CEL-1497810", "name": "Uncoupled eNOS favours the formation of superoxide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_29364" ], "products": [ "species_1222424", "species_29366" ], "modifiers": [ [ "species_10535152", "catalyst" ] ], "additional_components": [ "Q9XTG7", "WBGene00000103", "G4S4W1", "WBGene00016980", "Q17941", "WBGene00000102", "species_74016", "Q11083", "WBGene00020378", "P04630", "WBGene00000285", "G5EF37", "WBGene00003934", "A0A2C9C3L3", "WBGene00020378", "Q18136", "WBGene00006861", "Q09665", "WBGene00006583", "O02159", "WBGene00020378", "G5EDZ8", "WBGene00000288", "Q94288", "WBGene00000287", "Q09980", "WBGene00017394", "O16305", "WBGene00000552", "G5EEG0", "WBGene00000286", "Q18688", "WBGene00000915", "species_1497857", "species_71185", "species_216785", "species_73524", "species_113596", "species_29870" ] }, "reaction_10551508": { "compartment": "compartment_70101", "id": "reaction_10551508", "reactome": "R-CEL-5340226", "name": "CYGB dioxygenates NO", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_202124", "species_10551503", "species_70106", "species_29364" ], "products": [ "species_10551501", "species_432031", "species_29366" ], "modifiers": [ [ "species_10551503", "catalyst" ] ], "additional_components": [ "species_113534", "species_71185", "O17824", "WBGene00008996", "species_71185", "O17824", "WBGene00008996", "species_113534", "species_71185", "O17824", "WBGene00008996" ] }, "reaction_10567554": { "compartment": "compartment_70101", "id": "reaction_10567554", "reactome": "R-CEL-8876789", "name": "CARNMT1 methylates CARN to Anserine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6786250", "species_71284" ], "products": [ "species_71285", "species_8876775" ], "modifiers": [ [ "species_10567551", "catalyst" ] ], "additional_components": [ "WBGene00013015" ] }, "reaction_10503510": { "compartment": "compartment_70101", "id": "reaction_10503510", "reactome": "R-CEL-70903", "name": "urocanate + H2O => 4-imidazolone-5-propionate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_30721" ], "products": [ "species_34979" ], "modifiers": [ [ "species_10503507", "catalyst" ] ], "additional_components": [ "species_29360", "Q9NAE2", "WBGene00013103" ] }, "reaction_10503500": { "compartment": "compartment_70101", "id": "reaction_10503500", "reactome": "R-CEL-70899", "name": "histidine => urocanate + NH4+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29612" ], "products": [ "species_31633", "species_30721" ], "modifiers": [ [ "species_10503497", "catalyst" ] ], "additional_components": [ "WBGene00009813" ] }, "reaction_10503518": { "compartment": "compartment_70101", "id": "reaction_10503518", "reactome": "R-CEL-70906", "name": "4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_34979" ], "products": [ "species_30158", "species_70106" ], "modifiers": [ [ "species_10503515", "catalyst" ] ], "additional_components": [ "WBGene00020436" ] }, "reaction_10571277": { "compartment": "compartment_70101", "id": "reaction_10571277", "reactome": "R-CEL-9014641", "name": "HRSP12 deaminates 2AA to 2OBUTA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9014643" ], "products": [ "species_29382", "species_936714" ], "modifiers": [ [ "species_10571274", "catalyst" ] ], "additional_components": [ "WBGene00016011" ] }, "reaction_10503714": { "compartment": "compartment_5460", "id": "reaction_10503714", "reactome": "R-CEL-71037", "name": "alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_113526", "species_70951" ], "products": [ "species_70955", "species_29362", "species_29376" ], "modifiers": [ [ "species_10503711", "catalyst" ] ], "additional_components": [ "O61199", "WBGene00020679", "species_8878387", "CHEBI:17460", "O45148", "WBGene00020950", "O17953", "WBGene00010794", "species_113596" ] }, "reaction_10503541": { "compartment": "compartment_5460", "id": "reaction_10503541", "reactome": "R-CEL-70941", "name": "alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113526", "species_113556", "species_113521" ], "products": [ "species_113529", "species_508531", "species_29362" ], "modifiers": [ [ "species_10503538", "catalyst" ] ], "additional_components": [ "P46562", "WBGene00000115" ] }, "reaction_10503528": { "compartment": "compartment_5460", "id": "reaction_10503528", "reactome": "R-CEL-70938", "name": "lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113594", "species_113529", "species_29444", "species_113600" ], "products": [ "species_113563", "species_113521", "species_30176" ], "modifiers": [ [ "species_10503525", "catalyst" ] ], "additional_components": [ "U4PFH6", "WBGene00019819" ] }, "reaction_10503531": { "compartment": "compartment_5460", "id": "reaction_10503531", "reactome": "R-CEL-70940", "name": "saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113526", "species_113521", "species_30176" ], "products": [ "species_113529", "species_113556", "species_29362", "species_113552" ], "modifiers": [ [ "species_10503525", "catalyst" ] ], "additional_components": [ "U4PFH6", "WBGene00019819" ] }, "reaction_10518299": { "compartment": "compartment_5460", "id": "reaction_10518299", "reactome": "R-CEL-372480", "name": "2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113594", "species_113577" ], "products": [ "species_29406", "species_70951" ], "modifiers": [ [ "species_10518296", "catalyst" ] ], "additional_components": [ "WBGene00011226" ] }, "reaction_10503724": { "compartment": "compartment_5460", "id": "reaction_10503724", "reactome": "R-CEL-71046", "name": "glutaryl-CoA + FAD => crotonyl-CoA + FADH2 + CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113596", "species_70955" ], "products": [ "species_71045", "species_31649", "species_29376" ], "modifiers": [ [ "species_10503721", "catalyst" ] ], "additional_components": [ "Q20772", "WBGene00010052", "species_113596" ] }, "reaction_10558014": { "compartment": "compartment_17951", "id": "reaction_10558014", "reactome": "R-CEL-6783880", "name": "PIPOX oxidises PPCA to P6C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113535", "species_5693325" ], "products": [ "species_113575", "species_6783877" ], "modifiers": [ [ "species_10558011", "catalyst" ] ], "additional_components": [ "WBGene00015783" ] }, "reaction_10570157": { "compartment": "compartment_70101", "id": "reaction_10570157", "reactome": "R-CEL-8959510", "name": "SEPHS2 phosphorylates H2Se to form SELP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5357660", "species_29356", "species_113592" ], "products": [ "species_29372", "species_70106", "species_8959518", "species_76577" ], "modifiers": [ [ "species_10570154", "catalyst" ] ], "additional_components": [ "WBGene00012867" ] }, "reaction_10551250": { "compartment": "compartment_70101", "id": "reaction_10551250", "reactome": "R-CEL-5263616", "name": "MeSeO2H is reduced to MeSeOH by TXNRD1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5357694", "species_70106", "species_29364" ], "products": [ "species_5357663", "species_29356", "species_29366" ], "modifiers": [ [ "species_10506167", "catalyst" ] ], "additional_components": [ "Q17745", "WBGene00015553", "species_113596" ] }, "reaction_10551247": { "compartment": "compartment_70101", "id": "reaction_10551247", "reactome": "R-CEL-5263614", "name": "MeSeOH is reduced to MeSeH by TXNRD1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5357663", "species_70106", "species_29364" ], "products": [ "species_29356", "species_29366", "species_5357669" ], "modifiers": [ [ "species_10506167", "catalyst" ] ], "additional_components": [ "Q17745", "WBGene00015553", "species_113596" ] }, "reaction_10518289": { "compartment": "compartment_70101", "id": "reaction_10518289", "reactome": "R-CEL-372448", "name": "SLC25A12,13 exchange cytosolic L-Glu for mitochondrial matrix L-Asp", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29404", "species_113553" ], "products": [ "species_29448", "species_113552" ], "modifiers": [ [ "species_10518286", "catalyst" ] ], "additional_components": [ "Q21153", "WBGene00019326" ] }, "reaction_10503201": { "compartment": "compartment_5460", "id": "reaction_10503201", "reactome": "R-CEL-70596", "name": "GOT2 dimer deaminates L-Asp", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113594", "species_113553" ], "products": [ "species_113587", "species_113552" ], "modifiers": [ [ "species_10503198", "catalyst" ] ], "additional_components": [ "Q17994", "WBGene00015778" ] }, "reaction_10557141": { "compartment": "compartment_876", "id": "reaction_10557141", "reactome": "R-CEL-5693783", "name": "NAALADases hydrolyse NAAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5693762" ], "products": [ "species_29404", "species_5693772" ], "modifiers": [ [ "species_10557138", "catalyst" ] ], "additional_components": [ "P91406", "WBGene00020082", "Q93332", "WBGene00007954" ] }, "reaction_10503190": { "compartment": "compartment_70101", "id": "reaction_10503190", "reactome": "R-CEL-70592", "name": "PXLP-K259-GOT1 dimer deaminates L-Asp", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29406", "species_29448" ], "products": [ "species_29404", "species_76213" ], "modifiers": [ [ "species_10503175", "catalyst" ] ], "additional_components": [ "Q22067", "WBGene00020146" ] }, "reaction_10559320": { "compartment": "compartment_70101", "id": "reaction_10559320", "reactome": "R-CEL-6797627", "name": "ASPG hydrolyses L-Asn to L-Asp", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_29642" ], "products": [ "species_29448", "species_29382" ], "modifiers": [ [ "species_10559317", "catalyst" ] ], "additional_components": [ "WBGene00007756" ] }, "reaction_10503178": { "compartment": "compartment_70101", "id": "reaction_10503178", "reactome": "R-CEL-70581", "name": "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29404", "species_76213" ], "products": [ "species_29406", "species_29448" ], "modifiers": [ [ "species_10503175", "catalyst" ] ], "additional_components": [ "Q22067", "WBGene00020146" ] }, "reaction_10503296": { "compartment": "compartment_5460", "id": "reaction_10503296", "reactome": "R-CEL-70666", "name": "glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_31339", "species_113552" ], "products": [ "species_113594", "species_113585" ], "modifiers": [ [ "species_10503281", "catalyst" ] ], "additional_components": [ "Q18040", "WBGene00015814" ] }, "reaction_10503265": { "compartment": "compartment_5460", "id": "reaction_10503265", "reactome": "R-CEL-70613", "name": "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT2]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113587", "species_113552" ], "products": [ "species_113594", "species_113553" ], "modifiers": [ [ "species_10503198", "catalyst" ] ], "additional_components": [ "Q17994", "WBGene00015778" ] }, "reaction_10503203": { "compartment": "compartment_5460", "id": "reaction_10503203", "reactome": "R-CEL-70600", "name": "glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ [GLUD1]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113552", "species_113521", "species_517495" ], "products": [ "species_517496", "species_113594", "species_113529", "species_113561" ], "modifiers": [ [ "species_10503185", "catalyst" ], [ "species_113581", "catalyst" ], [ "species_113573", "inhibitor" ] ], "additional_components": [ "species_29360", "species_29366", "species_29364", "species_73473", "Q23621", "WBGene00014095" ] }, "reaction_10503188": { "compartment": "compartment_5460", "id": "reaction_10503188", "reactome": "R-CEL-70589", "name": "alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ [GLUD1]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_517496", "species_113594", "species_113529", "species_113561" ], "products": [ "species_113552", "species_113521", "species_517495" ], "modifiers": [ [ "species_10503185", "catalyst" ], [ "species_113581", "catalyst" ], [ "species_113573", "inhibitor" ] ], "additional_components": [ "species_29364", "species_73473", "species_29360", "species_29366", "Q23621", "WBGene00014095" ] }, "reaction_10558039": { "compartment": "compartment_70101", "id": "reaction_10558039", "reactome": "R-CEL-6783955", "name": "PYCRL decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_35305", "species_29364" ], "products": [ "species_29366", "species_113538" ], "modifiers": [ [ "species_10558036", "catalyst" ] ], "additional_components": [ "Q21544", "WBGene00010924", "Q20848", "WBGene00018904" ] }, "reaction_10527197": { "compartment": "compartment_5460", "id": "reaction_10527197", "reactome": "R-CEL-508040", "name": "glutamate + ATP + NADPH + H+ => L-glutamate gamma-semialdehyde + NADP+ + ADP + orthophosphate [P5CS]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113529", "species_113593", "species_113600", "species_113552" ], "products": [ "species_113548", "species_113581", "species_31339", "species_113563" ], "modifiers": [ [ "species_10527194", "catalyst" ] ], "additional_components": [ "P54889", "WBGene00011938" ] }, "reaction_10558028": { "compartment": "compartment_5460", "id": "reaction_10558028", "reactome": "R-CEL-6783939", "name": "PYCR2 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113529", "species_113590", "species_29362" ], "products": [ "species_113526", "species_379717" ], "modifiers": [ [ "species_10558025", "catalyst" ] ], "additional_components": [ "Q20848", "WBGene00018904", "Q21544", "WBGene00010924" ] }, "reaction_10503294": { "compartment": "compartment_5460", "id": "reaction_10503294", "reactome": "R-CEL-70664", "name": "PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113529", "species_113590", "species_29362" ], "products": [ "species_113526", "species_379717" ], "modifiers": [ [ "species_10503291", "catalyst" ] ], "additional_components": [ "Q21544", "WBGene00010924" ] }, "reaction_10528415": { "compartment": "compartment_70101", "id": "reaction_10528415", "reactome": "R-CEL-893616", "name": "glutamine + pyruvate => 2-oxoglutaramate + alanine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29398", "species_29472" ], "products": [ "species_29432", "species_893598" ], "modifiers": [ [ "species_10528406", "catalyst" ] ], "additional_components": [ "Q9XX97", "WBGene00009232", "Q8MP09", "WBGene00010984" ] }, "reaction_10516466": { "compartment": "compartment_70101", "id": "reaction_10516466", "reactome": "R-CEL-209924", "name": "Dopa is decarboxylated to dopamine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_209849" ], "products": [ "species_113528", "species_159362" ], "modifiers": [ [ "species_10516426", "catalyst" ] ], "additional_components": [ "O45137", "WBGene00000239" ] }, "reaction_10516446": { "compartment": "compartment_70101", "id": "reaction_10516446", "reactome": "R-CEL-209903", "name": "Noradrenaline is converted to adrenaline", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_209789", "species_71284" ], "products": [ "species_70106", "species_71285", "species_209794" ], "modifiers": [ [ "species_10516443", "catalyst" ] ], "additional_components": [ "Q20308", "WBGene00018340", "Q22279", "WBGene00011573", "P34254", "WBGene00015124" ] }, "reaction_10516399": { "compartment": "compartment_70101", "id": "reaction_10516399", "reactome": "R-CEL-209823", "name": "Tyrosine is hydroxylated to dopa", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29870", "species_29368", "species_29506" ], "products": [ "species_209849", "species_71112" ], "modifiers": [ [ "species_10516396", "catalyst" ] ], "additional_components": [ "species_113531", "P90986", "WBGene00000296" ] }, "reaction_10516464": { "compartment": "compartment_984", "id": "reaction_10516464", "reactome": "R-CEL-209921", "name": "Monoiodinated tyrosine can be deiodinated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351627", "species_351639" ], "products": [ "species_352030", "species_351628", "species_209818" ], "modifiers": [ [ "species_10516461", "catalyst" ] ], "additional_components": [ "species_73524", "P34273", "WBGene00015334" ] }, "reaction_10516468": { "compartment": "compartment_984", "id": "reaction_10516468", "reactome": "R-CEL-209925", "name": "DIT and MIT combine to form triiodothyronine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352329", "species_351639" ], "products": [ "species_352331", "species_352036" ], "modifiers": [ [ "species_10516386", "catalyst" ] ], "additional_components": [ "Q23490", "WBGene00022743", "P91060", "WBGene00015841", "Q1ENI8", "WBGene00004256", "G5EG78", "WBGene00004257", "Q20616", "WBGene00009897", "H2KZ53", "WBGene00017968" ] }, "reaction_10557028": { "compartment": "compartment_876", "id": "reaction_10557028", "reactome": "R-CEL-5693681", "name": "DUOX1,2 reduce O2 to H2O2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_351627", "species_352327" ], "products": [ "species_351628", "species_351629" ], "modifiers": [ [ "species_10557025", "catalyst" ] ], "additional_components": [ "O01795", "WBGene00018771", "O61213", "WBGene00000253" ] }, "reaction_10516389": { "compartment": "compartment_984", "id": "reaction_10516389", "reactome": "R-CEL-209815", "name": "Tyrosine is monoiodinated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351630", "species_352030" ], "products": [ "species_622410", "species_351639" ], "modifiers": [ [ "species_10516386", "catalyst" ] ], "additional_components": [ "Q23490", "WBGene00022743", "P91060", "WBGene00015841", "Q1ENI8", "WBGene00004256", "G5EG78", "WBGene00004257", "Q20616", "WBGene00009897", "H2KZ53", "WBGene00017968" ] }, "reaction_10516454": { "compartment": "compartment_876", "id": "reaction_10516454", "reactome": "R-CEL-209910", "name": "Iodide is taken up by thyroid epithelial cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_209818", "species_74113" ], "products": [ "species_209785", "species_83910" ], "modifiers": [ [ "species_10516451", "catalyst" ] ], "additional_components": [ "WBGene00018716" ] }, "reaction_10516470": { "compartment": "compartment_984", "id": "reaction_10516470", "reactome": "R-CEL-209960", "name": "Diiodinated tyrosine can be deiodinated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351627", "species_352329" ], "products": [ "species_352030", "species_351628", "species_209818" ], "modifiers": [ [ "species_10516461", "catalyst" ] ], "additional_components": [ "species_73524", "P34273", "WBGene00015334" ] }, "reaction_10516472": { "compartment": "compartment_984", "id": "reaction_10516472", "reactome": "R-CEL-209973", "name": "Tyrosine is diiodinated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_351627", "species_352030", "species_209818", "species_351629" ], "products": [ "species_109276", "species_352329", "species_351628" ], "modifiers": [ [ "species_10516386", "catalyst" ] ], "additional_components": [ "Q23490", "WBGene00022743", "P91060", "WBGene00015841", "Q1ENI8", "WBGene00004256", "G5EG78", "WBGene00004257", "Q20616", "WBGene00009897", "H2KZ53", "WBGene00017968" ] }, "reaction_10517997": { "compartment": "compartment_984", "id": "reaction_10517997", "reactome": "R-CEL-350901", "name": "Iodide is organified", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_351627", "species_209818", "species_351629" ], "products": [ "species_109276", "species_351630", "species_351628" ], "modifiers": [ [ "species_10516386", "catalyst" ] ], "additional_components": [ "Q23490", "WBGene00022743", "P91060", "WBGene00015841", "Q1ENI8", "WBGene00004256", "G5EG78", "WBGene00004257", "Q20616", "WBGene00009897", "H2KZ53", "WBGene00017968" ] }, "reaction_10516413": { "compartment": "compartment_984", "id": "reaction_10516413", "reactome": "R-CEL-209840", "name": "Two DITs combine to form thyroxine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352329" ], "products": [ "species_352326", "species_352036" ], "modifiers": [ [ "species_10516386", "catalyst" ] ], "additional_components": [ "Q23490", "WBGene00022743", "P91060", "WBGene00015841", "Q1ENI8", "WBGene00004256", "G5EG78", "WBGene00004257", "Q20616", "WBGene00009897", "H2KZ53", "WBGene00017968" ] }, "reaction_10567841": { "compartment": "compartment_5668575", "id": "reaction_10567841", "reactome": "R-CEL-8878581", "name": "TYRP1 oxidises DHICA to IQCA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5662670", "species_5668566" ], "products": [ "species_8878586", "species_5668574" ], "modifiers": [ [ "species_10567838", "catalyst" ] ], "additional_components": [ "O01497", "WBGene00016419", "O76708", "WBGene00021553", "P34269", "WBGene00015332", "Q19673", "WBGene00009001", "Q95XC6", "WBGene00022231", "Q9XUS8", "WBGene00010661" ] }, "reaction_10554582": { "compartment": "compartment_5668575", "id": "reaction_10554582", "reactome": "R-CEL-5662662", "name": "Tyrosinase oxidises tyrosine to dopaquinone", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5668573", "species_5668567" ], "products": [ "species_5668577", "species_5662695" ], "modifiers": [ [ "species_10554579", "catalyst" ] ], "additional_components": [ "P34269", "WBGene00015332", "species_209799" ] }, "reaction_10554584": { "compartment": "compartment_5668572", "id": "reaction_10554584", "reactome": "R-CEL-5662692", "name": "Dopa is oxidized to dopaquinone by TYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5668568", "species_5668566" ], "products": [ "species_5668574", "species_5662695" ], "modifiers": [ [ "species_10554579", "catalyst" ] ], "additional_components": [ "P34269", "WBGene00015332", "species_209799" ] }, "reaction_10554586": { "compartment": "compartment_5668572", "id": "reaction_10554586", "reactome": "R-CEL-5663050", "name": "DHI and DHICA polymerise forming eumelanin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5662708", "species_5662695" ], "products": [ "species_5668568", "species_5662678" ], "modifiers": [ [ "species_10554579", "catalyst" ] ], "additional_components": [ "species_5662670", "CHEBI:27404", "species_5662670", "CHEBI:27404", "P34269", "WBGene00015332", "species_209799" ] }, "reaction_10554575": { "compartment": "compartment_5668572", "id": "reaction_10554575", "reactome": "R-CEL-5662660", "name": "Dopachrome is transformed to DHICA by DCT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5662665" ], "products": [ "species_5662670" ], "modifiers": [ [ "species_10554572", "catalyst" ] ], "additional_components": [ "Q95XC6", "WBGene00022231", "O76708", "WBGene00021553", "P34269", "WBGene00015332", "Q9XUS8", "WBGene00010661", "O01497", "WBGene00016419", "Q19673", "WBGene00009001", "species_216785" ] }, "reaction_10559330": { "compartment": "compartment_5460", "id": "reaction_10559330", "reactome": "R-CEL-6797653", "name": "DMGDH:FAD oxidatively demethylates DMGLY to SARC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6797923", "species_113521" ], "products": [ "species_6797917", "species_6797920" ], "modifiers": [ [ "species_10559327", "catalyst" ] ], "additional_components": [ "A0A486WWC6", "WBGene00021355", "species_113596" ] }, "reaction_10559333": { "compartment": "compartment_5460", "id": "reaction_10559333", "reactome": "R-CEL-6797955", "name": "ALDH7A1 oxidises BETALD to BET", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113526", "species_6798194", "species_113521" ], "products": [ "species_6798202", "species_29362" ], "modifiers": [ [ "species_10503536", "catalyst" ] ], "additional_components": [ "WBGene00000115" ] }, "reaction_10559341": { "compartment": "compartment_5460", "id": "reaction_10559341", "reactome": "R-CEL-6797961", "name": "CHDH oxidises Cho to BETALD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113596", "species_6798162" ], "products": [ "species_6798194", "species_31649" ], "modifiers": [ [ "species_10559338", "catalyst" ] ], "additional_components": [ "WBGene00007917" ] }, "reaction_10569987": { "compartment": "compartment_5460", "id": "reaction_10569987", "reactome": "R-CEL-8955817", "name": "PRODH2 oxidises HPRO to 1PYR-5COOH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113597", "species_6784215" ], "products": [ "species_113590", "species_164934", "species_113521" ], "modifiers": [ [ "species_10558041", "catalyst" ] ], "additional_components": [ "WBGene00007197" ] }, "reaction_10503304": { "compartment": "compartment_5460", "id": "reaction_10503304", "reactome": "R-CEL-70670", "name": "PRODH oxidises L-Pro to 1PYR-5COOH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113597", "species_379717" ], "products": [ "species_113529", "species_113590", "species_164934" ], "modifiers": [ [ "species_10503301", "catalyst" ] ], "additional_components": [ "WBGene00007197" ] }, "reaction_10520736": { "compartment": "compartment_17951", "id": "reaction_10520736", "reactome": "R-CEL-389862", "name": "Conversion of glyoxylate to oxalate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113535", "species_141343", "species_389678" ], "products": [ "species_389819", "species_113575" ], "modifiers": [ [ "species_10520730", "catalyst" ] ], "additional_components": [ "B1GRK5", "WBGene00018286", "species_73524" ] }, "reaction_10559137": { "compartment": "compartment_5460", "id": "reaction_10559137", "reactome": "R-CEL-6793591", "name": "LIAS:2(4Fe-4S) transforms octanoyl-K107-GCSH to lipoyl-K107-GCSH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6793610", "species_2162265", "species_10559127" ], "products": [ "species_379705", "species_10557165", "species_6793613" ], "modifiers": [ [ "species_10559134", "catalyst" ] ], "additional_components": [ "WBGene00009918", "WBGene00009918", "CHEBI:49883", "Q21452", "WBGene00010809" ] }, "reaction_10558048": { "compartment": "compartment_5460", "id": "reaction_10558048", "reactome": "R-CEL-6784224", "name": "PRODH2:FAD dimer dehydrogenates HPRO to 1-pyrroline-3-hydroxy-5-carboxylate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6784215" ], "products": [ "species_6784241" ], "modifiers": [ [ "species_10558045", "catalyst" ] ], "additional_components": [ "O45228", "WBGene00007197", "species_113596" ] }, "reaction_10520721": { "compartment": "compartment_17951", "id": "reaction_10520721", "reactome": "R-CEL-389821", "name": "glycine + O2 => glyoxylate + H2O2 + NH4+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113535", "species_141343", "species_193446" ], "products": [ "species_389678", "species_389843", "species_113575" ], "modifiers": [ [ "species_10520718", "catalyst" ] ], "additional_components": [ "species_113596", "Q19564", "WBGene00017565", "Q95XG9", "WBGene00022076", "O01739", "WBGene00017648", "O45307", "WBGene00008127" ] }, "reaction_10559104": { "compartment": "compartment_5460", "id": "reaction_10559104", "reactome": "R-CEL-6792572", "name": "LIPT1 transfers lipoyl group from lipoyl-GCSH to DHs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10557165", "species_10559088" ], "products": [ "species_10557167", "species_10559096" ], "modifiers": [ [ "species_10559101", "catalyst" ] ], "additional_components": [ "WBGene00009918", "CHEBI:17460", "O45148", "WBGene00020950", "O61199", "WBGene00020679", "species_8878387", "O17953", "WBGene00010794", "species_113596", "Q93619", "WBGene00006518", "O45924", "WBGene00012713", "Q23571", "WBGene00014054", "P52899", "WBGene00011510", "O44451", "WBGene00015413", "Q19749", "WBGene00009082", "Q23629", "WBGene00014098", "WBGene00009918", "Q23571", "WBGene00014054", "Q93619", "WBGene00006518", "species_8878387", "O45924", "WBGene00012713", "O17953", "WBGene00010794", "species_113596", "Q23629", "WBGene00014098", "O61199", "WBGene00020679", "CHEBI:17460", "O45148", "WBGene00020950", "P52899", "WBGene00011510", "O44451", "WBGene00015413", "Q19749", "WBGene00009082", "WBGene00001590" ] }, "reaction_10558051": { "compartment": "compartment_5460", "id": "reaction_10558051", "reactome": "R-CEL-6784393", "name": "PXLP-K279-GOT2 dimer transaminates 4-OH-L-glutamate to 4-hydroxy-2-oxoglutarate (HOG)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6784236", "species_113587" ], "products": [ "species_6784229", "species_113553" ], "modifiers": [ [ "species_10503198", "catalyst" ] ], "additional_components": [ "Q17994", "WBGene00015778" ] }, "reaction_10520662": { "compartment": "compartment_17951", "id": "reaction_10520662", "reactome": "R-CEL-389684", "name": "glyoxylate + alanine => glycine + pyruvate [peroxisome]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_389678", "species_389664" ], "products": [ "species_389680", "species_193446" ], "modifiers": [ [ "species_10520659", "catalyst" ] ], "additional_components": [ "Q94055", "WBGene00011767" ] }, "reaction_10563702": { "compartment": "compartment_17951", "id": "reaction_10563702", "reactome": "R-CEL-6810076", "name": "DDO oxidizes D-Asp to OA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113535", "species_141343", "species_6810061" ], "products": [ "species_113575", "species_389843", "species_6810070" ], "modifiers": [ [ "species_10563699", "catalyst" ] ], "additional_components": [ "Q95XG9", "WBGene00022076", "species_113596" ] }, "reaction_10528441": { "compartment": "compartment_5460", "id": "reaction_10528441", "reactome": "R-CEL-904864", "name": "Mitochondrial AGXT2 tetramer transaminates glyoxylate and alanine to glycine and pyruvate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_904849", "species_379697" ], "products": [ "species_159549", "species_113557" ], "modifiers": [ [ "species_10528438", "catalyst" ] ], "additional_components": [ "O02158", "WBGene00020382" ] }, "reaction_10557190": { "compartment": "compartment_5460", "id": "reaction_10557190", "reactome": "R-CEL-5693977", "name": "AMT transfers NH2CH2 from GCSH:SAMDLL to THF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200671", "species_10557169" ], "products": [ "species_10557182", "species_5693978", "species_5693984" ], "modifiers": [ [ "species_10557187", "catalyst" ] ], "additional_components": [ "CHEBI:14949", "Q20634", "WBGene00009918", "CHEBI:50746", "Q20634", "WBGene00009918", "WBGene00017765" ] }, "reaction_10557195": { "compartment": "compartment_5460", "id": "reaction_10557195", "reactome": "R-CEL-5694018", "name": "DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10557182", "species_113526" ], "products": [ "species_10557165", "species_113529", "species_29362" ], "modifiers": [ [ "species_10557192", "catalyst" ] ], "additional_components": [ "CHEBI:50746", "Q20634", "WBGene00009918", "WBGene00009918", "O17953", "WBGene00010794", "species_113596" ] }, "reaction_10557180": { "compartment": "compartment_5460", "id": "reaction_10557180", "reactome": "R-CEL-5693967", "name": "PXLP-K754-GLDC dimer decarboxylates Gly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_159549", "species_10557165" ], "products": [ "species_10557169", "species_29376" ], "modifiers": [ [ "species_10557177", "catalyst" ] ], "additional_components": [ "WBGene00009918", "CHEBI:14949", "Q20634", "WBGene00009918", "Q21962", "WBGene00020022" ] }, "reaction_10520733": { "compartment": "compartment_17951", "id": "reaction_10520733", "reactome": "R-CEL-389842", "name": "HAO1 tetramer oxidizes glycolate to glyoxylate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113535", "species_389822" ], "products": [ "species_389678", "species_113575" ], "modifiers": [ [ "species_10520730", "catalyst" ] ], "additional_components": [ "B1GRK5", "WBGene00018286", "species_73524" ] }, "reaction_10503876": { "compartment": "compartment_70101", "id": "reaction_10503876", "reactome": "R-CEL-71249", "name": "SHMT1 tetramer cleaves HTMLYS to yield TEABL and Gly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_31503" ], "products": [ "species_31311", "species_29424" ], "modifiers": [ [ "species_10503873", "catalyst" ] ], "additional_components": [ "P50432", "WBGene00003214" ] }, "reaction_10503865": { "compartment": "compartment_5460", "id": "reaction_10503865", "reactome": "R-CEL-71241", "name": "TMLHE dimer dioxygenates TMLYS and 2OG to form HTMLYS and SUCCA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113533", "species_113594", "species_35139" ], "products": [ "species_113546", "species_113536", "species_29376" ], "modifiers": [ [ "species_10503862", "catalyst" ] ], "additional_components": [ "Q21526", "WBGene00001523", "species_198836", "species_113531" ] }, "reaction_10503886": { "compartment": "compartment_70101", "id": "reaction_10503886", "reactome": "R-CEL-71260", "name": "ALDH9A1 tetramer dehydrogenates TEABL to form TEABT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_31311", "species_29356", "species_29360" ], "products": [ "species_70106", "species_31369", "species_73473" ], "modifiers": [ [ "species_10503883", "catalyst" ] ], "additional_components": [ "Q20352", "WBGene00000117" ] }, "reaction_10534694": { "compartment": "compartment_5460", "id": "reaction_10534694", "reactome": "R-CEL-1475028", "name": "Carbonic anhydrase dehydrates bicarbonate (mitochondria)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29896", "species_113529" ], "products": [ "species_113521", "species_29376" ], "modifiers": [ [ "species_10534691", "catalyst" ] ], "additional_components": [ "species_216785", "O02637", "WBGene00000284", "Q10462", "WBGene00000283", "Q21614", "WBGene00000282", "Q27504", "WBGene00000281" ] }, "reaction_10534663": { "compartment": "compartment_70101", "id": "reaction_10534663", "reactome": "R-CEL-1475022", "name": "Carbonic anhydrase dehydrates bicarbonate (cytosol)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_111627" ], "products": [ "species_29356", "species_113528" ], "modifiers": [ [ "species_10534660", "catalyst" ] ], "additional_components": [ "O02637", "WBGene00000284", "Q10462", "WBGene00000283", "Q21614", "WBGene00000282", "Q27504", "WBGene00000281", "species_216785" ] }, "reaction_10534696": { "compartment": "compartment_5460", "id": "reaction_10534696", "reactome": "R-CEL-1475032", "name": "Carbonic anhydrase hydrates carbon dioxide (mitochondria)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113521", "species_29376" ], "products": [ "species_29896", "species_113529" ], "modifiers": [ [ "species_10534691", "catalyst" ] ], "additional_components": [ "species_216785", "O02637", "WBGene00000284", "Q10462", "WBGene00000283", "Q21614", "WBGene00000282", "Q27504", "WBGene00000281" ] }, "reaction_10534665": { "compartment": "compartment_70101", "id": "reaction_10534665", "reactome": "R-CEL-1475026", "name": "Carbonic anhydrase hydrates carbon dioxide (cytosol)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113528" ], "products": [ "species_70106", "species_111627" ], "modifiers": [ [ "species_10534660", "catalyst" ] ], "additional_components": [ "O02637", "WBGene00000284", "Q10462", "WBGene00000283", "Q21614", "WBGene00000282", "Q27504", "WBGene00000281", "species_216785" ] }, "reaction_10537601": { "compartment": "compartment_70101", "id": "reaction_10537601", "reactome": "R-CEL-1855166", "name": "PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_2023943" ], "products": [ "species_29372", "species_994141" ], "modifiers": [ [ "species_10537589", "catalyst" ] ], "additional_components": [ "species_1629736", "species_1629755", "CHEBI:62927", "Q95XC4", "WBGene00022366", "species_114632", "species_266099" ] }, "reaction_10537634": { "compartment": "compartment_70101", "id": "reaction_10537634", "reactome": "R-CEL-1855179", "name": "I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_994141" ], "products": [ "species_29370", "species_1629770" ], "modifiers": [ [ "species_10537631", "catalyst" ] ], "additional_components": [ "WBGene00012466" ] }, "reaction_10537666": { "compartment": "compartment_70101", "id": "reaction_10537666", "reactome": "R-CEL-1855194", "name": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/3 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1629740" ], "products": [ "species_1629732", "species_29370" ], "modifiers": [ [ "species_10537575", "catalyst" ] ], "additional_components": [ "Q9BKX8", "WBGene00021260", "O02167", "WBGene00021260", "Q93644", "WBGene00021260" ] }, "reaction_10537764": { "compartment": "compartment_70101", "id": "reaction_10537764", "reactome": "R-CEL-1855227", "name": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1629770" ], "products": [ "species_1629765", "species_29370" ], "modifiers": [ [ "species_10537575", "catalyst" ] ], "additional_components": [ "Q9BKX8", "WBGene00021260", "O02167", "WBGene00021260", "Q93644", "WBGene00021260" ] }, "reaction_10541476": { "compartment": "compartment_70101", "id": "reaction_10541476", "reactome": "R-CEL-2023971", "name": "1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_2023974" ], "products": [ "species_29372", "species_1629770" ], "modifiers": [ [ "species_10537595", "catalyst" ] ], "additional_components": [ "species_1629740", "CHEBI:62922", "species_114632", "Q95XC4", "WBGene00022366", "species_266099" ] }, "reaction_10537669": { "compartment": "compartment_70101", "id": "reaction_10537669", "reactome": "R-CEL-1855198", "name": "5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1629765", "species_29356" ], "products": [ "species_29372", "species_1629770" ], "modifiers": [ [ "species_10537595", "catalyst" ] ], "additional_components": [ "species_114632", "Q95XC4", "WBGene00022366", "species_266099" ] }, "reaction_10541478": { "compartment": "compartment_70101", "id": "reaction_10541478", "reactome": "R-CEL-2023973", "name": "(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2023968", "species_29356" ], "products": [ "species_29372", "species_2023974" ], "modifiers": [ [ "species_10537595", "catalyst" ] ], "additional_components": [ "species_1629732", "CHEBI:62924", "species_1629740", "CHEBI:62922", "species_114632", "Q95XC4", "WBGene00022366", "species_266099" ] }, "reaction_10537578": { "compartment": "compartment_70101", "id": "reaction_10537578", "reactome": "R-CEL-1855158", "name": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1629765", "species_113592" ], "products": [ "species_29370", "species_1629759" ], "modifiers": [ [ "species_10537575", "catalyst" ] ], "additional_components": [ "Q9BKX8", "WBGene00021260", "O02167", "WBGene00021260", "Q93644", "WBGene00021260" ] }, "reaction_10537652": { "compartment": "compartment_70101", "id": "reaction_10537652", "reactome": "R-CEL-1855182", "name": "5-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by PPIP5K1/2 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1629765", "species_113592" ], "products": [ "species_1629732", "species_29370" ], "modifiers": [ [ "species_10537649", "catalyst" ] ], "additional_components": [ "P91309", "WBGene00018508" ] }, "reaction_10537758": { "compartment": "compartment_70101", "id": "reaction_10537758", "reactome": "R-CEL-1855223", "name": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/3 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_994141" ], "products": [ "species_29370", "species_1629755" ], "modifiers": [ [ "species_10537575", "catalyst" ] ], "additional_components": [ "Q9BKX8", "WBGene00021260", "O02167", "WBGene00021260", "Q93644", "WBGene00021260" ] }, "reaction_10537726": { "compartment": "compartment_70101", "id": "reaction_10537726", "reactome": "R-CEL-1855216", "name": "IP6 is phosphorylated to 1-PP-IP5 by PPIP5K1/2 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1629770" ], "products": [ "species_29370", "species_1629740" ], "modifiers": [ [ "species_10537649", "catalyst" ] ], "additional_components": [ "P91309", "WBGene00018508" ] }, "reaction_10537598": { "compartment": "compartment_70101", "id": "reaction_10537598", "reactome": "R-CEL-1855165", "name": "(PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2023968", "species_29356" ], "products": [ "species_1629765", "species_29372" ], "modifiers": [ [ "species_10537595", "catalyst" ] ], "additional_components": [ "species_1629732", "CHEBI:62924", "species_114632", "Q95XC4", "WBGene00022366", "species_266099" ] }, "reaction_10537663": { "compartment": "compartment_70101", "id": "reaction_10537663", "reactome": "R-CEL-1855193", "name": "1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1629736" ], "products": [ "species_29370", "species_1629738" ], "modifiers": [ [ "species_10537575", "catalyst" ] ], "additional_components": [ "Q9BKX8", "WBGene00021260", "O02167", "WBGene00021260", "Q93644", "WBGene00021260" ] }, "reaction_10555333": { "compartment": "compartment_70101", "id": "reaction_10555333", "reactome": "R-CEL-5678327", "name": "MIOX oxidises Ins to GlcA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_426910" ], "products": [ "species_29356", "species_70106", "species_2162232" ], "modifiers": [ [ "species_10555330", "catalyst" ] ], "additional_components": [ "Q65CM5", "WBGene00016920", "species_113531" ] }, "reaction_10537637": { "compartment": "compartment_70101", "id": "reaction_10537637", "reactome": "R-CEL-1855180", "name": "I(1,3,4)P3 is dephosphorylated to I(1,3)P2 by INPP4A/B in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_994123" ], "products": [ "species_29372", "species_1629769" ], "modifiers": [ [ "species_10537307", "catalyst" ] ], "additional_components": [ "Q21623", "WBGene00010975" ] }, "reaction_10537606": { "compartment": "compartment_70101", "id": "reaction_10537606", "reactome": "R-CEL-1855174", "name": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_114520" ], "products": [ "species_29372", "species_1629739" ], "modifiers": [ [ "species_10537603", "catalyst" ] ], "additional_components": [ "O17590", "WBGene00007620", "P34370", "WBGene00086546", "G5ECL2", "WBGene00006763" ] }, "reaction_10537686": { "compartment": "compartment_70101", "id": "reaction_10537686", "reactome": "R-CEL-1855210", "name": "I3P is dephosphorylated to Ins by IMPA1/2 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1629731" ], "products": [ "species_29372", "species_426910" ], "modifiers": [ [ "species_10537530", "catalyst" ] ], "additional_components": [ "species_114632", "Q19420", "WBGene00008765" ] }, "reaction_10537672": { "compartment": "compartment_70101", "id": "reaction_10537672", "reactome": "R-CEL-1855202", "name": "I(3,4)P2 is dephosphorylated to I3P by INPP4A/B in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1629746" ], "products": [ "species_29372", "species_1629731" ], "modifiers": [ [ "species_10537307", "catalyst" ] ], "additional_components": [ "Q21623", "WBGene00010975" ] }, "reaction_10537689": { "compartment": "compartment_70101", "id": "reaction_10537689", "reactome": "R-CEL-1855211", "name": "I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1629753" ], "products": [ "species_29372", "species_426910" ], "modifiers": [ [ "species_10537530", "catalyst" ] ], "additional_components": [ "species_114632", "Q19420", "WBGene00008765" ] }, "reaction_10537755": { "compartment": "compartment_876", "id": "reaction_10537755", "reactome": "R-CEL-1855222", "name": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_114520" ], "products": [ "species_29372", "species_1629739" ], "modifiers": [ [ "species_10537752", "catalyst" ] ], "additional_components": [ "Q17848", "WBGene00002146", "O17590", "WBGene00007620" ] }, "reaction_10537533": { "compartment": "compartment_70101", "id": "reaction_10537533", "reactome": "R-CEL-1855154", "name": "I1P is dephosphorylated to Ins by IMPA1/2 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_870330" ], "products": [ "species_29372", "species_426910" ], "modifiers": [ [ "species_10537530", "catalyst" ] ], "additional_components": [ "species_114632", "Q19420", "WBGene00008765" ] }, "reaction_10537629": { "compartment": "compartment_70101", "id": "reaction_10537629", "reactome": "R-CEL-1855178", "name": "Glc6P is isomerised to I3P by ISYNA1 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1629756" ], "products": [ "species_1629731" ], "modifiers": [ [ "species_10537626", "catalyst" ] ], "additional_components": [ "species_29360", "G5ED01", "WBGene00012148" ] }, "reaction_10520816": { "compartment": "compartment_17951", "id": "reaction_10520816", "reactome": "R-CEL-390425", "name": "FAR1 reduces PalmCoA to HXOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_200993" ], "products": [ "species_29366", "species_8848577", "species_76194" ], "modifiers": [ [ "species_10520813", "catalyst" ] ], "additional_components": [ "WBGene00022200" ] }, "reaction_10564721": { "compartment": "compartment_12045", "id": "reaction_10564721", "reactome": "R-CEL-8848582", "name": "AWAT2 transfers PALM from PALM-CoA to HXOL, forming palmityl palmitate ester", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8848577", "species_200993" ], "products": [ "species_8848499", "species_76194" ], "modifiers": [ [ "species_10557641", "catalyst" ] ], "additional_components": [ "O01881", "WBGene00021818", "Q23067", "WBGene00020910", "Q9N4S3", "WBGene00021818", "Q9XUW0", "WBGene00010296" ] }, "reaction_10564724": { "compartment": "compartment_12045", "id": "reaction_10564724", "reactome": "R-CEL-8848585", "name": "AWAT2 transfers PALM from PALM-CoA to atROL, forming atR-PALM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200993", "species_30209" ], "products": [ "species_76194", "species_2534407" ], "modifiers": [ [ "species_10557641", "catalyst" ] ], "additional_components": [ "O01881", "WBGene00021818", "Q23067", "WBGene00020910", "Q9N4S3", "WBGene00021818", "Q9XUW0", "WBGene00010296" ] }, "reaction_10557631": { "compartment": "compartment_12045", "id": "reaction_10557631", "reactome": "R-CEL-5696424", "name": "AWAT1 transfers acyl group from acyl-CoA to ARACOH, forming wax esters", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_192172", "species_5696426" ], "products": [ "species_5696412", "species_162743" ], "modifiers": [ [ "species_10557628", "catalyst" ] ], "additional_components": [ "O01881", "WBGene00021818", "Q23067", "WBGene00020910", "Q9N4S3", "WBGene00021818", "Q9XUW0", "WBGene00010296" ] }, "reaction_10520819": { "compartment": "compartment_17951", "id": "reaction_10520819", "reactome": "R-CEL-390427", "name": "1-palmitoylglycerone phosphate + hexadecanol => O-hexadecylglycerone phosphate + palmitate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_390440", "species_390419" ], "products": [ "species_390409", "species_390435" ], "modifiers": [ [ "species_10507473", "catalyst" ] ], "additional_components": [ "G5EFP8", "WBGene00012911", "species_113596", "O45218", "WBGene00000081" ] }, "reaction_10507476": { "compartment": "compartment_17951", "id": "reaction_10507476", "reactome": "R-CEL-75879", "name": "palmitoyl-CoA + DHAP => 1-palmitoylglycerone phosphate + CoASH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_390426", "species_390404" ], "products": [ "species_193514", "species_390419" ], "modifiers": [ [ "species_10507473", "catalyst" ] ], "additional_components": [ "G5EFP8", "WBGene00012911", "species_113596", "O45218", "WBGene00000081" ] }, "reaction_10507484": { "compartment": "compartment_70101", "id": "reaction_10507484", "reactome": "R-CEL-75883", "name": "DHRS7B reduces GO3P to HXDG3P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_75973", "species_29364" ], "products": [ "species_29366", "species_390422" ], "modifiers": [ [ "species_10507481", "catalyst" ] ], "additional_components": [ "WBGene00000993" ] }, "reaction_10537136": { "compartment": "compartment_12045", "id": "reaction_10537136", "reactome": "R-CEL-1675813", "name": "PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_426639" ], "products": [ "species_29370", "species_1806234" ], "modifiers": [ [ "species_10537133", "catalyst" ] ], "additional_components": [ "O45318", "WBGene00022501", "Q23083", "WBGene00022501", "Q9XW63", "WBGene00013557" ] }, "reaction_10563689": { "compartment": "compartment_70101", "id": "reaction_10563689", "reactome": "R-CEL-6809764", "name": "SBF1 binds MTMR2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10563685", "species_10537108" ], "products": [ "species_10563687" ], "modifiers": [], "additional_components": [ "WBGene00003477", "WBGene00003475", "Q9N589", "WBGene00003475", "Q9TXP3", "WBGene00003477" ] }, "reaction_10537277": { "compartment": "compartment_12045", "id": "reaction_10537277", "reactome": "R-CEL-1676124", "name": "PI4P is dephosphorylated to PI by SACM1L at the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1806234" ], "products": [ "species_29372", "species_426639" ], "modifiers": [ [ "species_10537274", "catalyst" ] ], "additional_components": [ "WBGene00009264" ] }, "reaction_10563692": { "compartment": "compartment_70101", "id": "reaction_10563692", "reactome": "R-CEL-6809777", "name": "PI3P is dephosphorylated to PI by MTMR2:SBF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_5676030" ], "products": [ "species_29372", "species_426639" ], "modifiers": [ [ "species_10563687", "catalyst" ] ], "additional_components": [ "Q9N589", "WBGene00003475", "Q9TXP3", "WBGene00003477" ] }, "reaction_10563695": { "compartment": "compartment_70101", "id": "reaction_10563695", "reactome": "R-CEL-6809778", "name": "PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_6809774" ], "products": [ "species_29372", "species_422529" ], "modifiers": [ [ "species_10563687", "catalyst" ] ], "additional_components": [ "Q9N589", "WBGene00003475", "Q9TXP3", "WBGene00003477" ] }, "reaction_10537328": { "compartment": "compartment_171062", "id": "reaction_10537328", "reactome": "R-CEL-1676206", "name": "PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A at the early endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806180", "species_113592" ], "products": [ "species_29370", "species_1806238" ], "modifiers": [ [ "species_10537178", "catalyst" ] ], "additional_components": [ "G5EDY0", "WBGene00009552", "species_74016", "species_114632" ] }, "reaction_10563680": { "compartment": "compartment_171062", "id": "reaction_10563680", "reactome": "R-CEL-6809720", "name": "PI3P is dephosphorylated to PI by MTM1:MTMR12", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1806200" ], "products": [ "species_29372", "species_1806199" ], "modifiers": [ [ "species_10563671", "catalyst" ] ], "additional_components": [ "Q9N589", "WBGene00003475", "V6CJW9", "WBGene00021683" ] }, "reaction_10537219": { "compartment": "compartment_171062", "id": "reaction_10537219", "reactome": "R-CEL-1675974", "name": "PI is phosphorylated to PI4P by PI4K2A/B at the early endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806199", "species_113592" ], "products": [ "species_1806180", "species_29370" ], "modifiers": [ [ "species_10537098", "catalyst" ] ], "additional_components": [ "O45318", "WBGene00022501", "Q23083", "WBGene00022501" ] }, "reaction_10537286": { "compartment": "compartment_171062", "id": "reaction_10537286", "reactome": "R-CEL-1676141", "name": "PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1806200" ], "products": [ "species_29372", "species_1806199" ], "modifiers": [ [ "species_10537252", "catalyst" ] ], "additional_components": [ "Q9N589", "WBGene00003475", "Q22712", "WBGene00003476" ] }, "reaction_10537255": { "compartment": "compartment_171062", "id": "reaction_10537255", "reactome": "R-CEL-1676105", "name": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1806205" ], "products": [ "species_29372", "species_1806259" ], "modifiers": [ [ "species_10537252", "catalyst" ] ], "additional_components": [ "Q9N589", "WBGene00003475", "Q22712", "WBGene00003476" ] }, "reaction_10563673": { "compartment": "compartment_70101", "id": "reaction_10563673", "reactome": "R-CEL-6809680", "name": "MTMR12 binds MTM1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10563669", "species_10537106" ], "products": [ "species_10563671" ], "modifiers": [], "additional_components": [ "WBGene00021683", "WBGene00003475", "Q9N589", "WBGene00003475", "V6CJW9", "WBGene00021683" ] }, "reaction_10537196": { "compartment": "compartment_171062", "id": "reaction_10537196", "reactome": "R-CEL-1675939", "name": "PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806199", "species_113592" ], "products": [ "species_29370", "species_1806200" ], "modifiers": [ [ "species_10537193", "catalyst" ] ], "additional_components": [ "Q9TXI7", "WBGene00006932", "species_266099", "Q23669", "WBGene00014151", "G5EDY0", "WBGene00009552", "species_74016", "species_114632" ] }, "reaction_10563677": { "compartment": "compartment_70101", "id": "reaction_10563677", "reactome": "R-CEL-6809707", "name": "MTMR12 binds MTMR2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10563669", "species_10537108" ], "products": [ "species_10563675" ], "modifiers": [], "additional_components": [ "WBGene00021683", "WBGene00003475", "Q9N589", "WBGene00003475", "V6CJW9", "WBGene00021683" ] }, "reaction_10537310": { "compartment": "compartment_171062", "id": "reaction_10537310", "reactome": "R-CEL-1676162", "name": "PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1806238" ], "products": [ "species_29372", "species_1806200" ], "modifiers": [ [ "species_10537307", "catalyst" ] ], "additional_components": [ "Q21623", "WBGene00010975" ] }, "reaction_10564974": { "compartment": "compartment_70101", "id": "reaction_10564974", "reactome": "R-CEL-8849969", "name": "PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_8849959" ], "products": [ "species_29372", "species_8849958" ], "modifiers": [ [ "species_10564971", "catalyst" ] ], "additional_components": [ "species_179838", "species_202247", "species_179856", "species_1806200", "species_5334668", "species_6810408", "WBGene00012353" ] }, "reaction_10564261": { "compartment": "compartment_12045", "id": "reaction_10564261", "reactome": "R-CEL-6814254", "name": "PNPLA6 hydrolyzes LysoPtdCho", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_6814253" ], "products": [ "species_1498750", "species_1524021" ], "modifiers": [ [ "species_10564258", "catalyst" ] ], "additional_components": [ "Q21534", "WBGene00022718", "Q02331", "WBGene00022718" ] }, "reaction_10564484": { "compartment": "compartment_876", "id": "reaction_10564484", "reactome": "R-CEL-6814797", "name": "ENPP6 hydrolyzes lysophosphatidylcholine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_2239407" ], "products": [ "species_6814794", "species_6814795" ], "modifiers": [ [ "species_10564481", "catalyst" ] ], "additional_components": [ "O45359", "WBGene00020195", "Q17540", "WBGene00020195", "Q22129", "WBGene00020195" ] }, "reaction_10564134": { "compartment": "compartment_876", "id": "reaction_10564134", "reactome": "R-CEL-6813740", "name": "GDE1 hydrolyzes GroPIns", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_6813734" ], "products": [ "species_426910", "species_76114" ], "modifiers": [ [ "species_10564131", "catalyst" ] ], "additional_components": [ "WBGene00020446" ] }, "reaction_10542310": { "compartment": "compartment_17957", "id": "reaction_10542310", "reactome": "R-CEL-2046092", "name": "Desaturation of dihomo-gamma-lenolenoyl-CoA to arachidonoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_194697", "species_2046045" ], "products": [ "species_194653", "species_113519", "species_2046053" ], "modifiers": [ [ "species_10542305", "catalyst" ] ], "additional_components": [ "G5EG11", "WBGene00001396", "Q23221", "WBGene00001395" ] }, "reaction_10542312": { "compartment": "compartment_12045", "id": "reaction_10542312", "reactome": "R-CEL-2046093", "name": "Translocation of tetracosapentaenoyl-CoA to peroxisomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2046050", "species_211579" ], "products": [ "species_5228339", "species_2046055", "species_211606" ], "modifiers": [ [ "species_10520379", "catalyst" ] ], "additional_components": [ "WBGene00004061" ] }, "reaction_10542314": { "compartment": "compartment_17957", "id": "reaction_10542314", "reactome": "R-CEL-2046094", "name": "Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2046066", "species_2046042", "species_113601" ], "products": [ "species_113519", "species_113564", "species_162743", "species_159751", "species_2046045" ], "modifiers": [ [ "species_10527261", "catalyst" ] ], "additional_components": [ "WBGene00001241" ] }, "reaction_10542316": { "compartment": "compartment_12045", "id": "reaction_10542316", "reactome": "R-CEL-2046096", "name": "Desaturation of Linoleoyl-CoA to gamma-linolenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_194697", "species_2046063" ], "products": [ "species_194653", "species_113519", "species_2046042" ], "modifiers": [ [ "species_10542288", "catalyst" ] ], "additional_components": [ "WBGene00001395" ] }, "reaction_10542318": { "compartment": "compartment_17957", "id": "reaction_10542318", "reactome": "R-CEL-2046097", "name": "Desaturation of tetracosatetraenoyl-CoA to tetracosapentaenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_2046048", "species_194697" ], "products": [ "species_194653", "species_113519", "species_2046050" ], "modifiers": [ [ "species_10542288", "catalyst" ] ], "additional_components": [ "WBGene00001395" ] }, "reaction_10557520": { "compartment": "compartment_5460", "id": "reaction_10557520", "reactome": "R-CEL-5695989", "name": "ACAD11 dehydrogenates BH-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113596", "species_5695963" ], "products": [ "species_5695976", "species_31649" ], "modifiers": [ [ "species_10557517", "catalyst" ] ], "additional_components": [ "WBGene00019599" ] }, "reaction_10556512": { "compartment": "compartment_70101", "id": "reaction_10556512", "reactome": "R-CEL-5690043", "name": "Cytosolic ACOTs hydrolyse MCFA-CoA, LCFA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_5690044" ], "products": [ "species_5690064", "species_76194" ], "modifiers": [ [ "species_10556509", "catalyst" ] ], "additional_components": [ "species_5690542", "species_164991", "species_5690531", "species_174602", "O45003", "WBGene00020989", "Q9GYN3", "WBGene00020989", "B3WFZ3", "WBGene00020989", "O01862", "WBGene00020989", "P34419", "WBGene00018370" ] }, "reaction_10567219": { "compartment": "compartment_5460", "id": "reaction_10567219", "reactome": "R-CEL-8874745", "name": "ACAA2 tetramer transfers acyl group from Ac-CoA to acyl-CoA forming 3OA-CoA and CoA-SH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113559", "species_1524038" ], "products": [ "species_29374", "species_8874749" ], "modifiers": [ [ "species_10567216", "catalyst" ] ], "additional_components": [ "O45552", "WBGene00009952" ] }, "reaction_10564674": { "compartment": "compartment_70101", "id": "reaction_10564674", "reactome": "R-CEL-8848250", "name": "ACBD6 binds LCFA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10564670", "species_164991" ], "products": [ "species_10564672" ], "modifiers": [], "additional_components": [ "WBGene00011731", "species_164991", "Q9XVJ0", "WBGene00011731" ] }, "reaction_10564645": { "compartment": "compartment_17957", "id": "reaction_10564645", "reactome": "R-CEL-8848246", "name": "DBI, ACBD7 bind MCFA-CoA and LCFA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8848288", "species_10564641" ], "products": [ "species_10564643" ], "modifiers": [], "additional_components": [ "species_164991", "species_5690542", "Q09603", "WBGene00001153", "Q09603", "WBGene00001153", "species_164991", "species_5690542" ] }, "reaction_10556532": { "compartment": "compartment_5460", "id": "reaction_10556532", "reactome": "R-CEL-5690066", "name": "ACOT2,9,THEM4,5 hydrolyse MCFA-CoA, LCFA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5690540", "species_113521" ], "products": [ "species_29374", "species_5690519" ], "modifiers": [ [ "species_10556529", "catalyst" ] ], "additional_components": [ "species_164991", "species_5690542", "species_174602", "species_5690531", "B3WFZ3", "WBGene00020989", "O01862", "WBGene00020989", "O45003", "WBGene00020989", "Q9GYN3", "WBGene00020989", "Q94245", "WBGene00019015" ] }, "reaction_10503674": { "compartment": "compartment_5460", "id": "reaction_10503674", "reactome": "R-CEL-71020", "name": "D-methylmalonyl-CoA <=> L-methylmalonyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71019" ], "products": [ "species_71009" ], "modifiers": [ [ "species_10503671", "catalyst" ] ], "additional_components": [ "WBGene00008415" ] }, "reaction_10503692": { "compartment": "compartment_5460", "id": "reaction_10503692", "reactome": "R-CEL-71031", "name": "propionyl-CoA + CO2 + ATP <=> D-methylmalonyl-CoA + ADP + orthophosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70843", "species_113593", "species_29376" ], "products": [ "species_113548", "species_113581", "species_71019" ], "modifiers": [ [ "species_10503689", "catalyst" ] ], "additional_components": [ "Q19842", "WBGene00017864", "Q20676", "WBGene00018701" ] }, "reaction_10508264": { "compartment": "compartment_5460", "id": "reaction_10508264", "reactome": "R-CEL-77338", "name": "Octanoyl-CoA+FAD<=>trans-Oct-2-enoyl-CoA+FADH2", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113596", "species_77337" ], "products": [ "species_77332", "species_31649" ], "modifiers": [ [ "species_10508261", "catalyst" ] ], "additional_components": [ "Q22347", "WBGene00020366" ] }, "reaction_10508250": { "compartment": "compartment_5460", "id": "reaction_10508250", "reactome": "R-CEL-77329", "name": "3-Oxooctanoyl-CoA+CoA-SH<=>Hexanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_77328" ], "products": [ "species_77326", "species_113559" ], "modifiers": [ [ "species_10508211", "catalyst" ] ], "additional_components": [ "P34255", "WBGene00015125", "Q9GYT0", "WBGene00020347" ] }, "reaction_10508252": { "compartment": "compartment_5460", "id": "reaction_10508252", "reactome": "R-CEL-77331", "name": "(S)-Hydroxyoctanoyl-CoA+NAD<=>3-Oxooctanoyl-CoA+NADH+H", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113526", "species_77330" ], "products": [ "species_113529", "species_29362", "species_77328" ], "modifiers": [ [ "species_10508194", "catalyst" ] ], "additional_components": [ "P41938", "WBGene00007129" ] }, "reaction_10508254": { "compartment": "compartment_5460", "id": "reaction_10508254", "reactome": "R-CEL-77333", "name": "trans-Oct-2-enoyl-CoA+H2O<=>(S)-Hydroxyoctanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77332", "species_113521" ], "products": [ "species_77330" ], "modifiers": [ [ "species_10503463", "catalyst" ] ], "additional_components": [ "P34559", "WBGene00001155" ] }, "reaction_10508272": { "compartment": "compartment_5460", "id": "reaction_10508272", "reactome": "R-CEL-77345", "name": "Decanoyl-CoA+FAD<=>trans-Dec-2-enoyl-CoA+FADH2", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77308", "species_113596" ], "products": [ "species_77343", "species_31649" ], "modifiers": [ [ "species_10508261", "catalyst" ] ], "additional_components": [ "Q22347", "WBGene00020366" ] }, "reaction_10569787": { "compartment": "compartment_5460", "id": "reaction_10569787", "reactome": "R-CEL-8952873", "name": "MECR dimer reduces tdec2-CoA to DEC-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77343", "species_113529", "species_113600" ], "products": [ "species_77308", "species_113563" ], "modifiers": [ [ "species_10569784", "catalyst" ] ], "additional_components": [ "O45903", "WBGene00012375" ] }, "reaction_10508266": { "compartment": "compartment_5460", "id": "reaction_10508266", "reactome": "R-CEL-77340", "name": "3-Oxodecanoyl-CoA+CoA-SH<=>Octanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_77339" ], "products": [ "species_77337", "species_113559" ], "modifiers": [ [ "species_10508211", "catalyst" ] ], "additional_components": [ "P34255", "WBGene00015125", "Q9GYT0", "WBGene00020347" ] }, "reaction_10508268": { "compartment": "compartment_5460", "id": "reaction_10508268", "reactome": "R-CEL-77342", "name": "(S)-Hydroxydecanoyl-CoA+NAD<=>3-Oxodecanoyl-CoA+NADH+H", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77341", "species_113526" ], "products": [ "species_77339", "species_113529", "species_29362" ], "modifiers": [ [ "species_10508194", "catalyst" ] ], "additional_components": [ "P41938", "WBGene00007129" ] }, "reaction_10508270": { "compartment": "compartment_5460", "id": "reaction_10508270", "reactome": "R-CEL-77344", "name": "trans-Dec-2-enoyl-CoA+H2O<=>(S)-Hydroxydecanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77343", "species_113521" ], "products": [ "species_77341" ], "modifiers": [ [ "species_10503463", "catalyst" ] ], "additional_components": [ "P34559", "WBGene00001155" ] }, "reaction_10508230": { "compartment": "compartment_5460", "id": "reaction_10508230", "reactome": "R-CEL-77299", "name": "palmitoyl-CoA+FAD<=>trans-Hexadec-2-enoyl-CoA+FADH2", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113596", "species_77281" ], "products": [ "species_77284", "species_31649" ], "modifiers": [ [ "species_10508227", "catalyst" ] ], "additional_components": [ "Q19057", "WBGene00017125" ] }, "reaction_10508232": { "compartment": "compartment_5460", "id": "reaction_10508232", "reactome": "R-CEL-77301", "name": "trans-Hexadec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxyhexadecanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77284", "species_113521" ], "products": [ "species_77300" ], "modifiers": [ [ "species_10508211", "catalyst" ] ], "additional_components": [ "P34255", "WBGene00015125", "Q9GYT0", "WBGene00020347" ] }, "reaction_10508234": { "compartment": "compartment_5460", "id": "reaction_10508234", "reactome": "R-CEL-77303", "name": "(S)-3-Hydroxyhexadecanoyl-CoA+NAD<=>3-Oxopalmitoyl-CoA+NADH+H", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113526", "species_77300" ], "products": [ "species_113529", "species_77302", "species_29362" ], "modifiers": [ [ "species_10508211", "catalyst" ] ], "additional_components": [ "P34255", "WBGene00015125", "Q9GYT0", "WBGene00020347" ] }, "reaction_10508236": { "compartment": "compartment_5460", "id": "reaction_10508236", "reactome": "R-CEL-77304", "name": "3-Oxopalmitoyl-CoA+CoA-SH<=>myristoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_77302" ], "products": [ "species_77272", "species_113559" ], "modifiers": [ [ "species_10508211", "catalyst" ] ], "additional_components": [ "P34255", "WBGene00015125", "Q9GYT0", "WBGene00020347" ] }, "reaction_10557528": { "compartment": "compartment_5460", "id": "reaction_10557528", "reactome": "R-CEL-5696004", "name": "ACSF2 ligates CoA-SH to MCFA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_113593", "species_5690531" ], "products": [ "species_159448", "species_159450", "species_5690542" ], "modifiers": [ [ "species_10557525", "catalyst" ] ], "additional_components": [ "WBGene00018488" ] }, "reaction_10508370": { "compartment": "compartment_5460", "id": "reaction_10508370", "reactome": "R-CEL-109341", "name": "dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113596", "species_109986" ], "products": [ "species_109990", "species_31649" ], "modifiers": [ [ "species_10508261", "catalyst" ] ], "additional_components": [ "Q22347", "WBGene00020366" ] }, "reaction_10508380": { "compartment": "compartment_5460", "id": "reaction_10508380", "reactome": "R-CEL-109343", "name": "Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113529", "species_109990", "species_29362" ], "products": [ "species_109994", "species_113526" ], "modifiers": [ [ "species_10508377", "catalyst" ] ], "additional_components": [ "Q23116", "WBGene00012177" ] }, "reaction_10542993": { "compartment": "compartment_12045", "id": "reaction_10542993", "reactome": "R-CEL-2161814", "name": "Arachidonic acid is hydroxylated to 19-HETE by CYP(2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_140356", "species_113601" ], "products": [ "species_113519", "species_113564", "species_2142836" ], "modifiers": [ [ "species_10542990", "catalyst" ] ], "additional_components": [ "A0A0M7RF98", "WBGene00018264", "Q27465", "WBGene00015135", "G5ECD0", "WBGene00007362", "Q27470", "WBGene00015709", "G5EE22", "WBGene00012448", "Q27471", "WBGene00016092", "H2KY69", "WBGene00015044", "Q27482", "WBGene00016768", "H2KYS3", "WBGene00000905", "Q27499", "WBGene00018334", "O02627", "WBGene00015399", "Q965T7", "WBGene00021710", "O02628", "WBGene00015400", "Q9N4Q4", "WBGene00021168", "O02641", "WBGene00019967", "Q9N5I1", "WBGene00019565", "O16220", "WBGene00016786", "O16362", "WBGene00018413", "O16482", "WBGene00016860", "O16670", "WBGene00018262", "O16671", "WBGene00018261", "O16673", "WBGene00018260", "O44649", "WBGene00019473", "O44650", "WBGene00019472", "O44651", "WBGene00019471", "O44652", "WBGene00019470", "O44655", "WBGene00015040", "O44656", "WBGene00015041", "O44657", "WBGene00015042", "O44658", "WBGene00015043", "O44704", "WBGene00016686", "O44706", "WBGene00016697", "O45364", "WBGene00008829", "O45659", "WBGene00010589", "O61204", "WBGene00015045", "O61935", "WBGene00020386", "O62377", "WBGene00011699", "O62378", "WBGene00011698", "P90771", "WBGene00007913", "Q20315", "WBGene00018333", "Q9N525", "WBGene00021412", "O17851", "WBGene00009226", "Q9N574", "WBGene00021200", "O45219", "WBGene00007140", "G5EC97", "WBGene00011830", "Q9XVA6", "WBGene00008499", "Q09660", "WBGene00000375", "G5EGT6", "WBGene00010354" ] }, "reaction_10543003": { "compartment": "compartment_12045", "id": "reaction_10543003", "reactome": "R-CEL-2161940", "name": "Arachidonic acid is hydroxylated to 20-HETE by CYP(3)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_140356", "species_113601" ], "products": [ "species_113519", "species_113564", "species_2142780" ], "modifiers": [ [ "species_10543000", "catalyst" ] ], "additional_components": [ "A0A0M7RF98", "WBGene00018264", "Q27465", "WBGene00015135", "G5ECD0", "WBGene00007362", "Q27470", "WBGene00015709", "G5EE22", "WBGene00012448", "Q27471", "WBGene00016092", "H2KY69", "WBGene00015044", "Q27482", "WBGene00016768", "H2KYS3", "WBGene00000905", "Q27499", "WBGene00018334", "O02627", "WBGene00015399", "Q965T7", "WBGene00021710", "O02628", "WBGene00015400", "Q9N4Q4", "WBGene00021168", "O02641", "WBGene00019967", "Q9N5I1", "WBGene00019565", "O16220", "WBGene00016786", "O16362", "WBGene00018413", "O16482", "WBGene00016860", "O16670", "WBGene00018262", "O16671", "WBGene00018261", "O16673", "WBGene00018260", "O44649", "WBGene00019473", "O44650", "WBGene00019472", "O44651", "WBGene00019471", "O44652", "WBGene00019470", "O44655", "WBGene00015040", "O44656", "WBGene00015041", "O44657", "WBGene00015042", "O44658", "WBGene00015043", "O44704", "WBGene00016686", "O44706", "WBGene00016697", "O45364", "WBGene00008829", "O45659", "WBGene00010589", "O61204", "WBGene00015045", "O61935", "WBGene00020386", "O62377", "WBGene00011699", "O62378", "WBGene00011698", "P90771", "WBGene00007913", "Q20315", "WBGene00018333", "Q9XVA6", "WBGene00008499", "G5EC97", "WBGene00011830", "G5EGT6", "WBGene00010354", "O17851", "WBGene00009226", "O45219", "WBGene00007140", "Q09660", "WBGene00000375", "Q9N525", "WBGene00021412", "Q9N574", "WBGene00021200" ] }, "reaction_10557108": { "compartment": "compartment_12045", "id": "reaction_10557108", "reactome": "R-CEL-5693742", "name": "FAAH hydrolyses AEA to AA and ETA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_5693754" ], "products": [ "species_1498751", "species_29768" ], "modifiers": [ [ "species_10557105", "catalyst" ] ], "additional_components": [ "Q17449", "WBGene00015047", "Q9U217", "WBGene00013232", "O45089", "WBGene00019068", "Q17447", "WBGene00015048", "Q9U243", "WBGene00013226", "Q9U2I8", "WBGene00012750" ] }, "reaction_10568057": { "compartment": "compartment_984", "id": "reaction_10568057", "reactome": "R-CEL-8932633", "name": "PON1,2,3:Ca2+ dimers hydrolyse 5-HETEL to 5-HETE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_8932801" ], "products": [ "species_8932804" ], "modifiers": [ [ "species_10568054", "catalyst" ] ], "additional_components": [ "species_74016", "B1V898", "WBGene00077701", "O01811", "WBGene00003170", "Q21427", "WBGene00010775", "Q2V071", "WBGene00044697", "Q966L1", "WBGene00017089" ] }, "reaction_10517856": { "compartment": "compartment_876", "id": "reaction_10517856", "reactome": "R-CEL-266070", "name": "LTC4 is exported from the cytosol by ABCC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_266066" ], "products": [ "species_266013" ], "modifiers": [ [ "species_10517853", "catalyst" ] ], "additional_components": [ "WBGene00003407" ] }, "reaction_10517848": { "compartment": "compartment_876", "id": "reaction_10517848", "reactome": "R-CEL-266046", "name": "GGT1, 5 dimers hydrolyse LTC4 to LTD4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_266013" ], "products": [ "species_266074", "species_210382" ], "modifiers": [ [ "species_10517845", "catalyst" ] ], "additional_components": [ "A0A486WVP7", "WBGene00020590", "B5BM47", "WBGene00020590", "H2L0B7", "WBGene00020590", "O18256", "WBGene00020590", "Q9N5V4", "WBGene00020590" ] }, "reaction_10542985": { "compartment": "compartment_12045", "id": "reaction_10542985", "reactome": "R-CEL-2161745", "name": "20oh-LTB4 is oxidised to 20cho-LTB4 by CYP4F2/4F3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29368", "species_29364", "species_2161636" ], "products": [ "species_29356", "species_29366", "species_2142740" ], "modifiers": [ [ "species_10516925", "catalyst" ] ], "additional_components": [ "Q9XVA6", "WBGene00008499", "G5EC97", "WBGene00011830", "G5EGT6", "WBGene00010354", "O17851", "WBGene00009226", "O45219", "WBGene00007140", "Q09660", "WBGene00000375", "Q9N525", "WBGene00021412", "Q9N574", "WBGene00021200" ] }, "reaction_10517866": { "compartment": "compartment_70101", "id": "reaction_10517866", "reactome": "R-CEL-266072", "name": "LTA4 is hydolysed to LTB4 by LTA4H", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_265281" ], "products": [ "species_266056" ], "modifiers": [ [ "species_10517863", "catalyst" ] ], "additional_components": [ "species_216785", "G5EFT4", "WBGene00016589" ] }, "reaction_10542988": { "compartment": "compartment_12045", "id": "reaction_10542988", "reactome": "R-CEL-2161792", "name": "20cho-LTB4 is oxidised to 20cooh-LTB4 by CYP4F2/4F3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29368", "species_29364", "species_2142740" ], "products": [ "species_2161582", "species_29356", "species_29366" ], "modifiers": [ [ "species_10516925", "catalyst" ] ], "additional_components": [ "Q9XVA6", "WBGene00008499", "G5EC97", "WBGene00011830", "G5EGT6", "WBGene00010354", "O17851", "WBGene00009226", "O45219", "WBGene00007140", "Q09660", "WBGene00000375", "Q9N525", "WBGene00021412", "Q9N574", "WBGene00021200" ] }, "reaction_10543012": { "compartment": "compartment_70101", "id": "reaction_10543012", "reactome": "R-CEL-2161959", "name": "12R-HpETE is reduced to 12R-HETE by GPX1/2/4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29450", "species_2142790" ], "products": [ "species_29356", "species_2142716", "species_111745" ], "modifiers": [ [ "species_10543009", "catalyst" ] ], "additional_components": [ "WBGene00019846" ] }, "reaction_10543014": { "compartment": "compartment_70101", "id": "reaction_10543014", "reactome": "R-CEL-2161999", "name": "12S-HpETE is reduced to 12S-HETE by GPX1/2/4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2142811", "species_29450" ], "products": [ "species_29356", "species_2142678", "species_111745" ], "modifiers": [ [ "species_10543009", "catalyst" ] ], "additional_components": [ "WBGene00019846" ] }, "reaction_10557116": { "compartment": "compartment_13977", "id": "reaction_10557116", "reactome": "R-CEL-5693751", "name": "FAAH2 hydrolyses AEA to AA and ETA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5693752", "species_5693747" ], "products": [ "species_5693736", "species_5693733" ], "modifiers": [ [ "species_10557113", "catalyst" ] ], "additional_components": [ "WBGene00013164" ] }, "reaction_10506598": { "compartment": "compartment_5460", "id": "reaction_10506598", "reactome": "R-CEL-74181", "name": "acetoacetyl-CoA + CoA <=> 2 acetyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_73871" ], "products": [ "species_113559" ], "modifiers": [ [ "species_10503443", "catalyst" ] ], "additional_components": [ "Q22100", "WBGene00002183" ] }, "reaction_10506586": { "compartment": "compartment_5460", "id": "reaction_10506586", "reactome": "R-CEL-74177", "name": "OXCT dimers transfer CoA from SUCC-CoA to ACA, forming ACA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70958", "species_73909" ], "products": [ "species_73871", "species_113536" ], "modifiers": [ [ "species_10506583", "catalyst" ] ], "additional_components": [ "Q09450", "WBGene00007330" ] }, "reaction_10506419": { "compartment": "compartment_5460", "id": "reaction_10506419", "reactome": "R-CEL-73918", "name": "acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73871", "species_113559" ], "products": [ "species_29374", "species_73917" ], "modifiers": [ [ "species_10506416", "catalyst" ] ], "additional_components": [ "WBGene00017769" ] }, "reaction_10506596": { "compartment": "compartment_5460", "id": "reaction_10506596", "reactome": "R-CEL-74180", "name": "HMG CoA => acetoacetic acid + acetyl CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73917" ], "products": [ "species_113559", "species_73909" ], "modifiers": [ [ "species_10506593", "catalyst" ] ], "additional_components": [ "Q95XN1", "WBGene00022150" ] }, "reaction_10557499": { "compartment": "compartment_70101", "id": "reaction_10557499", "reactome": "R-CEL-5694494", "name": "AACS ligates CoA-SH to ACA, forming ACA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_76194", "species_29666" ], "products": [ "species_111294", "species_191293", "species_76577" ], "modifiers": [ [ "species_10557496", "catalyst" ] ], "additional_components": [ "WBGene00006351" ] }, "reaction_10558315": { "compartment": "compartment_70101", "id": "reaction_10558315", "reactome": "R-CEL-6788597", "name": "HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191374" ], "products": [ "species_76183", "species_29666" ], "modifiers": [ [ "species_10558312", "catalyst" ] ], "additional_components": [ "species_114632", "Q95XN1", "WBGene00022150" ] }, "reaction_10536353": { "compartment": "compartment_161320", "id": "reaction_10536353", "reactome": "R-CEL-1605624", "name": "Beta-galactosidase hydrolyses GM1 to GM2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_1605677" ], "products": [ "species_1605637", "species_1605610" ], "modifiers": [ [ "species_10536350", "catalyst" ] ], "additional_components": [ "WBGene00011832" ] }, "reaction_10536324": { "compartment": "compartment_17938", "id": "reaction_10536324", "reactome": "R-CEL-1605591", "name": "Glucosylceramidase cleaves the glucosidic bond of glucocerebroside to form ceramide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_1605592" ], "products": [ "species_1605745", "species_1605673" ], "modifiers": [ [ "species_10536321", "catalyst" ] ], "additional_components": [ "G5ECR8", "WBGene00008706", "Q18276", "WBGene00004995" ] }, "reaction_10536360": { "compartment": "compartment_161320", "id": "reaction_10536360", "reactome": "R-CEL-1605632", "name": "Both hexosaminidase A and B can cleave GalNAc from globoside", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_1605608" ], "products": [ "species_1605716", "species_1605658" ], "modifiers": [ [ "species_10536357", "catalyst" ] ], "additional_components": [ "Q22492", "WBGene00020509" ] }, "reaction_10536680": { "compartment": "compartment_876", "id": "reaction_10536680", "reactome": "R-CEL-1640164", "name": "Ectonucleotide pyrophosphatase/phosphodiesterase 7 (ENPP7) hydrolyses sphingomyelin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_429776" ], "products": [ "species_429807", "species_1610735" ], "modifiers": [ [ "species_10536677", "catalyst" ] ], "additional_components": [ "Q22129", "WBGene00020195", "O45359", "WBGene00020195", "Q17540", "WBGene00020195" ] }, "reaction_10537833": { "compartment": "compartment_876", "id": "reaction_10537833", "reactome": "R-CEL-1861788", "name": "Glucosylceramidase 2 cleaves the glucosidic bond of glucocerebroside to form ceramide (plasma membrane)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1861782" ], "products": [ "species_429807", "species_70113" ], "modifiers": [ [ "species_10537830", "catalyst" ] ], "additional_components": [ "WBGene00019965" ] }, "reaction_10536363": { "compartment": "compartment_161320", "id": "reaction_10536363", "reactome": "R-CEL-1605717", "name": "Ganglioside GM2 activator presents GM2 to hexosaminidase for cleavage", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10536329", "species_1605610" ], "products": [ "species_10536331" ], "modifiers": [ [ "species_10536329", "catalyst" ] ], "additional_components": [ "WBGene00021095", "species_1605610", "O02106", "WBGene00021095", "WBGene00021095" ] }, "reaction_10536427": { "compartment": "compartment_876", "id": "reaction_10536427", "reactome": "R-CEL-1606273", "name": "Sphingomyelin phosphodiesterase 2 and 3 (SMPD2 and 3) hydrolyse sphingomyelin to ceramide (plasma membrane)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_429776" ], "products": [ "species_429807", "species_1610735" ], "modifiers": [ [ "species_10536424", "catalyst" ] ], "additional_components": [ "O45870", "WBGene00012105", "species_114632" ] }, "reaction_10536459": { "compartment": "compartment_161320", "id": "reaction_10536459", "reactome": "R-CEL-1606602", "name": "Acid ceramidase hydrolyses ceramide into sphingosine and free fatty acid (lysosome)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_1605673" ], "products": [ "species_1861779", "species_1606588" ], "modifiers": [ [ "species_10536456", "catalyst" ] ], "additional_components": [ "O45686", "WBGene00010769" ] }, "reaction_10536652": { "compartment": "compartment_20699", "id": "reaction_10536652", "reactome": "R-CEL-1638104", "name": "Ceramide glucosyltransferase (UGCG) catalyses the transfer of glucose to ceramide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_744227", "species_428270" ], "products": [ "species_1660674", "species_205687" ], "modifiers": [ [ "species_10536649", "catalyst" ] ], "additional_components": [ "WBGene00017625" ] }, "reaction_10567887": { "compartment": "compartment_17963", "id": "reaction_10567887", "reactome": "R-CEL-8878914", "name": "B3GALNT1 transfer GalNAc to Gb3Cer to form Gb4Cer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_735700", "species_8879102" ], "products": [ "species_8879101", "species_205687" ], "modifiers": [ [ "species_10567884", "catalyst" ] ], "additional_components": [ "WBGene00000270" ] }, "reaction_10558126": { "compartment": "compartment_70101", "id": "reaction_10558126", "reactome": "R-CEL-6785933", "name": "UGT8 transfers Gal from UDP-Gal to CERA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29452", "species_429807" ], "products": [ "species_6785915", "species_110096" ], "modifiers": [ [ "species_10558123", "catalyst" ] ], "additional_components": [ "WBGene00012013" ] }, "reaction_10537842": { "compartment": "compartment_70101", "id": "reaction_10537842", "reactome": "R-CEL-1861789", "name": "Glucosylceramidase 3 cleaves the glucosidic bond of glucocerebroside to form ceramide (cytosol)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1861764" ], "products": [ "species_194377", "species_70113" ], "modifiers": [ [ "species_10537839", "catalyst" ] ], "additional_components": [ "Q18758", "WBGene00016848", "Q9TZA0", "WBGene00017103" ] }, "reaction_10551475": { "compartment": "compartment_70101", "id": "reaction_10551475", "reactome": "R-CEL-5339535", "name": "GLTPD1 transports C1P from plasma membrane to Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1638840" ], "products": [ "species_5339515" ], "modifiers": [ [ "species_10551472", "catalyst" ] ], "additional_components": [ "WBGene00018632" ] }, "reaction_10536660": { "compartment": "compartment_876", "id": "reaction_10536660", "reactome": "R-CEL-1638845", "name": "CERK phosphorylates CERA to form C1P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_429807", "species_113592" ], "products": [ "species_29370", "species_1638840" ], "modifiers": [ [ "species_10536657", "catalyst" ] ], "additional_components": [ "WBGene00020398" ] }, "reaction_10536373": { "compartment": "compartment_161320", "id": "reaction_10536373", "reactome": "R-CEL-1605736", "name": "Alpha-galactosidase A removes a terminal galactose from alpha-D-galactoside oligomers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605716", "species_1605715" ], "products": [ "species_1605637", "species_1605601" ], "modifiers": [ [ "species_10536370", "catalyst" ] ], "additional_components": [ "Q21801", "WBGene00011095" ] }, "reaction_10536437": { "compartment": "compartment_17957", "id": "reaction_10536437", "reactome": "R-CEL-1606288", "name": "Sphingomyelin phosphodiesterase 4 (SMPD4) hydrolyses sphingomyelin to ceramide (ER membrane)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113519", "species_1606283" ], "products": [ "species_428256", "species_1606280" ], "modifiers": [ [ "species_10536434", "catalyst" ] ], "additional_components": [ "Q95ZR2", "WBGene00011037", "species_114632" ] }, "reaction_10536439": { "compartment": "compartment_161320", "id": "reaction_10536439", "reactome": "R-CEL-1606312", "name": "Beta-galactosidase can also hydrolyse globosides to form cerebrosides", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_1605601" ], "products": [ "species_1605637", "species_1605592" ], "modifiers": [ [ "species_10536350", "catalyst" ] ], "additional_components": [ "WBGene00011832" ] }, "reaction_10536345": { "compartment": "compartment_161320", "id": "reaction_10536345", "reactome": "R-CEL-1605595", "name": "Hexosaminidase A cleaves GalNAc from GM2 to form GM3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_10536331" ], "products": [ "species_10536329", "species_1605658", "species_1605641" ], "modifiers": [ [ "species_10536342", "catalyst" ] ], "additional_components": [ "species_1605610", "O02106", "WBGene00021095", "WBGene00021095", "Q22492", "WBGene00020509" ] }, "reaction_10536381": { "compartment": "compartment_161320", "id": "reaction_10536381", "reactome": "R-CEL-1605797", "name": "Sphingomyelin phosphodiesterase (SMPD1) hydrolyses sphingomyelin to ceramide (lysosome)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_1605713" ], "products": [ "species_1605750", "species_1605673" ], "modifiers": [ [ "species_10536378", "catalyst" ] ], "additional_components": [ "WBGene00000212" ] }, "reaction_10551516": { "compartment": "compartment_876", "id": "reaction_10551516", "reactome": "R-CEL-5340320", "name": "GLTP transports GSL from plasma membrane to ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5340315" ], "products": [ "species_5340299" ], "modifiers": [ [ "species_10551513", "catalyst" ] ], "additional_components": [ "WBGene00022347" ] }, "reaction_10565820": { "compartment": "compartment_12045", "id": "reaction_10565820", "reactome": "R-CEL-8857662", "name": "ESYT1:ESYT2:ESYT3 transport GPL from plasma membrane to ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8857646" ], "products": [ "species_8857684" ], "modifiers": [ [ "species_10565817", "catalyst" ], [ "species_74016", "catalyst" ] ], "additional_components": [ "A0A679L8R0", "WBGene00020443" ] }, "reaction_10536447": { "compartment": "compartment_161320", "id": "reaction_10536447", "reactome": "R-CEL-1606564", "name": "Galactocerebrosidase cleaves the galactosyl bond of galactocerebroside to form ceramide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_1606573" ], "products": [ "species_1605745", "species_1605673" ], "modifiers": [ [ "species_10536444", "catalyst" ] ], "additional_components": [ "WBGene00016207" ] }, "reaction_10523456": { "compartment": "compartment_70101", "id": "reaction_10523456", "reactome": "R-CEL-429698", "name": "PRKD1,2,3 phosphorylates COL4A3BP-2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10523428" ], "products": [ "species_29370", "species_10523431" ], "modifiers": [ [ "species_10523453", "catalyst" ] ], "additional_components": [ "WBGene00009120", "WBGene00009120", "Q9XUJ7", "WBGene00012352", "O45818", "WBGene00012019" ] }, "reaction_10556864": { "compartment": "compartment_12045", "id": "reaction_10556864", "reactome": "R-CEL-5692261", "name": "ALDH3A2-1 oxidises HD2NAL to PALM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_428671", "species_29360" ], "products": [ "species_70106", "species_3632881", "species_73473" ], "modifiers": [ [ "species_10556861", "catalyst" ] ], "additional_components": [ "A0A486WWU7", "WBGene00000110", "O44555", "WBGene00000111" ] }, "reaction_10523106": { "compartment": "compartment_70101", "id": "reaction_10523106", "reactome": "R-CEL-428214", "name": "sphinganine (dihydrosphingosine) +ATP => sphinganine 1-phosphate + ADP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_428163" ], "products": [ "species_29370", "species_428275" ], "modifiers": [ [ "species_10520872", "catalyst" ] ], "additional_components": [ "WBGene00007918" ] }, "reaction_10570149": { "compartment": "compartment_12045", "id": "reaction_10570149", "reactome": "R-CEL-8959462", "name": "SAMD8 transforms PE and CERA to CPE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8959490", "species_8959486" ], "products": [ "species_8959463" ], "modifiers": [ [ "species_10570146", "catalyst" ] ], "additional_components": [ "WBGene00018735" ] }, "reaction_10557124": { "compartment": "compartment_12045", "id": "reaction_10557124", "reactome": "R-CEL-5693761", "name": "FA2H hydroxylates CERA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_428256" ], "products": [ "species_5693768", "species_29356" ], "modifiers": [ [ "species_10557121", "catalyst" ] ], "additional_components": [ "WBGene00007707" ] }, "reaction_10523111": { "compartment": "compartment_70101", "id": "reaction_10523111", "reactome": "R-CEL-428231", "name": "ceramide + H2O <=> stearate + sphingosine [endoplasmic reticulum]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_428256" ], "products": [ "species_428193", "species_428198" ], "modifiers": [ [ "species_10523108", "catalyst" ] ], "additional_components": [ "WBGene00020947" ] }, "reaction_10523207": { "compartment": "compartment_70101", "id": "reaction_10523207", "reactome": "R-CEL-428676", "name": "sphingosine 1-phosphate => phosphoethanolamine + hexadec-2-enal", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428203" ], "products": [ "species_428671", "species_428686" ], "modifiers": [ [ "species_10523204", "catalyst" ] ], "additional_components": [ "WBGene00004981" ] }, "reaction_10563430": { "compartment": "compartment_13977", "id": "reaction_10563430", "reactome": "R-CEL-6808464", "name": "ALDH3B2 oxidises HXAL to PALM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_6808468", "species_29360" ], "products": [ "species_2453691", "species_70106", "species_73473" ], "modifiers": [ [ "species_10563427", "catalyst" ] ], "additional_components": [ "O44555", "WBGene00000111", "A0A486WWU7", "WBGene00000110" ] }, "reaction_10523209": { "compartment": "compartment_70101", "id": "reaction_10523209", "reactome": "R-CEL-428681", "name": "sphinganine 1-phosphate => phosphoethanolamine + hexadecanal", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428275" ], "products": [ "species_428686", "species_428663" ], "modifiers": [ [ "species_10523204", "catalyst" ] ], "additional_components": [ "WBGene00004981" ] }, "reaction_10523051": { "compartment": "compartment_70101", "id": "reaction_10523051", "reactome": "R-CEL-428123", "name": "3-ketosphinganine + NADPH + H+ => sphinganine + NADP+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_428182" ], "products": [ "species_29366", "species_428163" ], "modifiers": [ [ "species_10523048", "catalyst" ] ], "additional_components": [ "WBGene00021367" ] }, "reaction_10523468": { "compartment": "compartment_70101", "id": "reaction_10523468", "reactome": "R-CEL-429714", "name": "monophospho-CERT + 2 ATP => multiphospho-CERT + 2 ADP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10523431" ], "products": [ "species_29370", "species_10523460" ], "modifiers": [ [ "species_10523465", "catalyst" ] ], "additional_components": [ "WBGene00009120", "WBGene00009120", "WBGene00013709" ] }, "reaction_10523217": { "compartment": "compartment_984", "id": "reaction_10523217", "reactome": "R-CEL-428690", "name": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [extracellular]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_419305", "species_109276" ], "products": [ "species_109277", "species_428662" ], "modifiers": [ [ "species_10523214", "catalyst" ] ], "additional_components": [ "WBGene00018756" ] }, "reaction_10523251": { "compartment": "compartment_70101", "id": "reaction_10523251", "reactome": "R-CEL-428696", "name": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - PPAP]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428203", "species_29356" ], "products": [ "species_428682", "species_29372" ], "modifiers": [ [ "species_10523248", "catalyst" ] ], "additional_components": [ "Q22250", "WBGene00011524", "H2KZD1", "WBGene00018756", "Q10022", "WBGene00020895", "Q19403", "WBGene00008749" ] }, "reaction_10573237": { "compartment": "compartment_70101", "id": "reaction_10573237", "reactome": "R-CEL-9695890", "name": "SPNS2 transports S1P from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428203" ], "products": [ "species_419305" ], "modifiers": [ [ "species_10573234", "catalyst" ] ], "additional_components": [ "A0A3B1DV80", "WBGene00013739", "Q19235", "WBGene00008598", "O01927", "WBGene00007549", "Q18545", "WBGene00008033" ] }, "reaction_10523509": { "compartment": "compartment_876", "id": "reaction_10523509", "reactome": "R-CEL-429786", "name": "phosphatidylcholine + ceramide <=> sphingomyelin + diacylglycerol [SGMS2]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_429802", "species_429807" ], "products": [ "species_429776", "species_112275" ], "modifiers": [ [ "species_10523506", "catalyst" ] ], "additional_components": [ "Q9U3D4", "WBGene00004892", "Q965Q4", "WBGene00004894", "Q9TYV2", "WBGene00021075", "Q20735", "WBGene00004893" ] }, "reaction_10523093": { "compartment": "compartment_70101", "id": "reaction_10523093", "reactome": "R-CEL-428185", "name": "sphinganine + stearyl-CoA => dihydroceramide + CoASH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428139", "species_428163" ], "products": [ "species_428126", "species_76194" ], "modifiers": [ [ "species_10523090", "catalyst" ] ], "additional_components": [ "Q9XWE9", "WBGene00006505", "G5ED45", "WBGene00002043", "Q7Z139", "WBGene00002044" ] }, "reaction_10523126": { "compartment": "compartment_70101", "id": "reaction_10523126", "reactome": "R-CEL-428259", "name": "dihydroceramide + NAD(P)H + H+ + O2 => ceramide + NAD(P)+ + H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_428206", "species_428126", "species_29368" ], "products": [ "species_428218", "species_29356", "species_428256" ], "modifiers": [ [ "species_10523123", "catalyst" ] ], "additional_components": [ "species_73473", "species_29364", "species_29360", "species_29366", "O44186", "WBGene00017996", "G5EC63", "WBGene00013197" ] }, "reaction_10557561": { "compartment": "compartment_876", "id": "reaction_10557561", "reactome": "R-CEL-5696080", "name": "ALDH3B1 oxidises HXAL to PALM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_428663", "species_29360" ], "products": [ "species_70106", "species_3632881", "species_73473" ], "modifiers": [ [ "species_10557558", "catalyst" ] ], "additional_components": [ "A0A486WWU7", "WBGene00000110", "O44555", "WBGene00000111" ] }, "reaction_10523129": { "compartment": "compartment_70101", "id": "reaction_10523129", "reactome": "R-CEL-428260", "name": "dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_428126", "species_29368", "species_29364" ], "products": [ "species_29356", "species_29366", "species_9025544" ], "modifiers": [ [ "species_10523123", "catalyst" ] ], "additional_components": [ "O44186", "WBGene00017996", "G5EC63", "WBGene00013197" ] }, "reaction_10523514": { "compartment": "compartment_20699", "id": "reaction_10523514", "reactome": "R-CEL-429798", "name": "phosphatidylcholine + ceramide <=> sphingomyelin + diacylglycerol [SGMS1]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_429785", "species_428270" ], "products": [ "species_429773", "species_429789" ], "modifiers": [ [ "species_10523511", "catalyst" ] ], "additional_components": [ "WBGene00004892" ] }, "reaction_10573242": { "compartment": "compartment_70101", "id": "reaction_10573242", "reactome": "R-CEL-9695949", "name": "SPHK2 phosphorylates SPG to S1P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_428193" ], "products": [ "species_428203", "species_29370" ], "modifiers": [ [ "species_10523103", "catalyst" ], [ "species_10573240", "inhibitor" ] ], "additional_components": [ "WBGene00007918", "Q18425", "WBGene00007918" ] }, "reaction_10523132": { "compartment": "compartment_70101", "id": "reaction_10523132", "reactome": "R-CEL-428273", "name": "SPHK1 phosphorylates SPG to S1P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_428193" ], "products": [ "species_428203", "species_29370" ], "modifiers": [ [ "species_10520872", "catalyst" ] ], "additional_components": [ "WBGene00007918" ] }, "reaction_10523101": { "compartment": "compartment_20699", "id": "reaction_10523101", "reactome": "R-CEL-428205", "name": "ceramide + H2O => stearate + sphingosine [Golgi]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_428270" ], "products": [ "species_428248", "species_8934421" ], "modifiers": [ [ "species_10523098", "catalyst" ] ], "additional_components": [ "WBGene00020947" ] }, "reaction_10536978": { "compartment": "compartment_20699", "id": "reaction_10536978", "reactome": "R-CEL-1655851", "name": "S2P hydrolyzes SREBP1A,1C,2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10536972" ], "products": [ "species_10536935" ], "modifiers": [ [ "species_10522008", "catalyst" ] ], "additional_components": [ "WBGene00004735", "WBGene00004735", "WBGene00013225" ] }, "reaction_10542407": { "compartment": "compartment_7660", "id": "reaction_10542407", "reactome": "R-CEL-2065539", "name": "SREBP1A,1C,2:Importin beta-1 dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10536955", "species_10542403" ], "products": [ "species_10536951", "species_10542405" ], "modifiers": [], "additional_components": [ "Q9XX00", "WBGene00004735", "Q9BIB8", "WBGene00002075", "O17915", "WBGene00004302", "species_29438", "Q9XX00", "WBGene00004735", "O17915", "WBGene00004302", "species_29438", "Q9BIB8", "WBGene00002075" ] }, "reaction_10542409": { "compartment": "compartment_70101", "id": "reaction_10542409", "reactome": "R-CEL-2065549", "name": "SREBP1A,1C,2 binds SREBP1A,1C,2 forming dimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10536935" ], "products": [ "species_10536941" ], "modifiers": [], "additional_components": [ "WBGene00004735", "Q9XX00", "WBGene00004735" ] }, "reaction_10542411": { "compartment": "compartment_70101", "id": "reaction_10542411", "reactome": "R-CEL-2065550", "name": "SREBP1A,1C,2 binds Importin beta-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10536941", "species_10516892" ], "products": [ "species_10536943" ], "modifiers": [], "additional_components": [ "Q9XX00", "WBGene00004735", "WBGene00002075", "Q9BIB8", "WBGene00002075", "Q9XX00", "WBGene00004735" ] }, "reaction_10536957": { "compartment": "compartment_70101", "id": "reaction_10536957", "reactome": "R-CEL-1655831", "name": "SREBP1A,1C,2 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10536943" ], "products": [ "species_10536955" ], "modifiers": [], "additional_components": [ "Q9BIB8", "WBGene00002075", "Q9XX00", "WBGene00004735", "Q9XX00", "WBGene00004735", "Q9BIB8", "WBGene00002075" ] }, "reaction_10557203": { "compartment": "compartment_12045", "id": "reaction_10557203", "reactome": "R-CEL-5694077", "name": "EPHX1 hydrates BaP4,5O to BaP4,5-DHD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_5694080" ], "products": [ "species_5694091" ], "modifiers": [ [ "species_10557200", "catalyst" ] ], "additional_components": [ "WBGene00020909" ] }, "reaction_10568323": { "compartment": "compartment_70101", "id": "reaction_10568323", "reactome": "R-CEL-8937442", "name": "CES3 hydrolyses CHEST to CHOL and LCFA(-)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_163579" ], "products": [ "species_8876730", "species_216762" ], "modifiers": [ [ "species_10568320", "catalyst" ] ], "additional_components": [ "O01302", "WBGene00011362", "P92016", "WBGene00011364", "Q04457", "WBGene00001578", "Q21266", "WBGene00019477", "A0A1C3NSL8", "WBGene00017478", "Q22008", "WBGene00020125", "G5EDJ7", "WBGene00013875", "Q23268", "WBGene00013873", "H2L0K7", "WBGene00020330", "Q4LDP0", "WBGene00020891", "H9G2Y9", "WBGene00013874", "Q9XW75", "WBGene00013540" ] }, "reaction_10517444": { "compartment": "compartment_17960", "id": "reaction_10517444", "reactome": "R-CEL-217255", "name": "FMO1:FAD N-oxidises TAM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_113601", "species_159154" ], "products": [ "species_113519", "species_113564", "species_217269" ], "modifiers": [ [ "species_10517441", "catalyst" ] ], "additional_components": [ "species_113596", "G5EBJ9", "WBGene00001477", "G5ECJ8", "WBGene00001478", "G5ED43", "WBGene00001480", "G5EDG8", "WBGene00001479", "G5EDP6", "WBGene00001476" ] }, "reaction_10517461": { "compartment": "compartment_17960", "id": "reaction_10517461", "reactome": "R-CEL-217258", "name": "FMO2:FAD:Mg2+ S-oxidises MTZ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_113601", "species_217315" ], "products": [ "species_113519", "species_113564", "species_217320" ], "modifiers": [ [ "species_10517458", "catalyst" ] ], "additional_components": [ "G5EBJ9", "WBGene00001477", "G5ECJ8", "WBGene00001478", "G5ED43", "WBGene00001480", "G5EDG8", "WBGene00001479", "G5EDP6", "WBGene00001476", "species_114632", "species_113596" ] }, "reaction_10509718": { "compartment": "compartment_17957", "id": "reaction_10509718", "reactome": "R-CEL-139970", "name": "FMO3:FAD N-oxidises TMA to TMAO", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_30373", "species_113601" ], "products": [ "species_113519", "species_113564", "species_140963" ], "modifiers": [ [ "species_10509715", "catalyst" ] ], "additional_components": [ "G5ECJ8", "WBGene00001478", "G5ED43", "WBGene00001480", "G5EDG8", "WBGene00001479", "G5EBJ9", "WBGene00001477", "G5EDP6", "WBGene00001476", "species_113596" ] }, "reaction_10504257": { "compartment": "compartment_70101", "id": "reaction_10504257", "reactome": "R-CEL-71707", "name": "ethanol + NAD+ => acetaldehyde + NADH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30203", "species_29360" ], "products": [ "species_70106", "species_29510", "species_73473" ], "modifiers": [ [ "species_10504254", "catalyst" ] ], "additional_components": [ "species_216785", "Q17335", "WBGene00019240" ] }, "reaction_10557573": { "compartment": "compartment_5460", "id": "reaction_10557573", "reactome": "R-CEL-5696091", "name": "ALDH1B1 tetramer oxidises CH3CHO to CH3COOH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113532", "species_113526", "species_113521" ], "products": [ "species_113529", "species_29362", "species_113539" ], "modifiers": [ [ "species_10557570", "catalyst" ] ], "additional_components": [ "Q20780", "WBGene00000107", "Q9TXM0", "WBGene00000108" ] }, "reaction_10556853": { "compartment": "compartment_70101", "id": "reaction_10556853", "reactome": "R-CEL-5692237", "name": "ADH5 oxidises S-HMGSH to S-FGSH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5692221", "species_29360" ], "products": [ "species_5692249", "species_70106", "species_73473" ], "modifiers": [ [ "species_10556850", "catalyst" ] ], "additional_components": [ "species_216785", "Q17335", "WBGene00019240" ] }, "reaction_10504267": { "compartment": "compartment_5460", "id": "reaction_10504267", "reactome": "R-CEL-71723", "name": "acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113532", "species_113526", "species_113521" ], "products": [ "species_113529", "species_29362", "species_113539" ], "modifiers": [ [ "species_10504264", "catalyst" ] ], "additional_components": [ "Q20780", "WBGene00000107" ] }, "reaction_10504285": { "compartment": "compartment_70101", "id": "reaction_10504285", "reactome": "R-CEL-71735", "name": "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_29416", "species_76194" ], "products": [ "species_111294", "species_76183", "species_76577" ], "modifiers": [ [ "species_10504282", "catalyst" ] ], "additional_components": [ "WBGene00007969" ] }, "reaction_10557063": { "compartment": "compartment_17957", "id": "reaction_10557063", "reactome": "R-CEL-5693691", "name": "CES1 trimer.CES2 hydrolyse COCN to BEG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113519", "species_5693702" ], "products": [ "species_156540", "species_5693711", "species_5693712" ], "modifiers": [ [ "species_10557060", "catalyst" ] ], "additional_components": [ "H9G2Y9", "WBGene00013874", "Q9XW75", "WBGene00013540", "O01302", "WBGene00011362", "P92016", "WBGene00011364", "Q04457", "WBGene00001578", "Q21266", "WBGene00019477", "A0A1C3NSL8", "WBGene00017478", "Q22008", "WBGene00020125", "G5EDJ7", "WBGene00013875", "Q23268", "WBGene00013873", "H2L0K7", "WBGene00020330", "Q4LDP0", "WBGene00020891" ] }, "reaction_10556121": { "compartment": "compartment_12045", "id": "reaction_10556121", "reactome": "R-CEL-5689000", "name": "AADAC deacetylates PHEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_5689006" ], "products": [ "species_5689001", "species_5688995" ], "modifiers": [ [ "species_10556118", "catalyst" ] ], "additional_components": [ "Q19839", "WBGene00009186", "Q9XWL5", "WBGene00012810", "Q7JMM5", "WBGene00017515", "Q94187", "WBGene00017515" ] }, "reaction_10558105": { "compartment": "compartment_70101", "id": "reaction_10558105", "reactome": "R-CEL-6784959", "name": "BPHL hydrolyses VACV to ACV", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_6784964" ], "products": [ "species_29702", "species_561052" ], "modifiers": [ [ "species_10558102", "catalyst" ] ], "additional_components": [ "WBGene00019280" ] }, "reaction_10556888": { "compartment": "compartment_70101", "id": "reaction_10556888", "reactome": "R-CEL-5692283", "name": "ALD3A1 oxidises 4HPCP to CXPA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5692409", "species_29356", "species_29366" ], "products": [ "species_70106", "species_5692433", "species_29364" ], "modifiers": [ [ "species_10556870", "catalyst" ], [ "species_10556882", "catalyst" ], [ "species_10556886", "inhibitor" ] ], "additional_components": [ "A0A486WWU7", "WBGene00000110", "O44555", "WBGene00000111", "O02219", "WBGene00000095", "species_8936852", "O44712", "WBGene00000096", "O44712", "WBGene00000096", "O02219", "WBGene00000095" ] }, "reaction_10568168": { "compartment": "compartment_70101", "id": "reaction_10568168", "reactome": "R-CEL-8936442", "name": "MARC1,MARC2 reduce N-hydroxylated compounds", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_8936443", "species_73473" ], "products": [ "species_29356", "species_29468", "species_29360" ], "modifiers": [ [ "species_10568165", "catalyst" ] ], "additional_components": [ "CHEBI:21437", "U4PC34", "WBGene00018925", "Q93315", "WBGene00007848", "O16521", "WBGene00020268", "P91321", "WBGene00018925", "O45394", "WBGene00018925" ] }, "reaction_10544101": { "compartment": "compartment_5460", "id": "reaction_10544101", "reactome": "R-CEL-2395512", "name": "FDXR transfers electrons to FDX1,2 (FDX1L)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10533041", "species_10544097" ], "products": [ "species_10533037", "species_113529", "species_10544099" ], "modifiers": [], "additional_components": [ "CHEBI:33737", "Q9NA32", "WBGene00013532", "species_31649", "Q9U1X0", "WBGene00013376", "CHEBI:33738", "Q9NA32", "WBGene00013532", "species_113596", "Q9U1X0", "WBGene00013376" ] }, "reaction_10544103": { "compartment": "compartment_5460", "id": "reaction_10544103", "reactome": "R-CEL-2395517", "name": "NADPH transfers electrons to FDXR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113529", "species_10544099", "species_113600" ], "products": [ "species_113563", "species_10544097" ], "modifiers": [], "additional_components": [ "species_113596", "Q9U1X0", "WBGene00013376", "species_31649", "Q9U1X0", "WBGene00013376" ] }, "reaction_10533044": { "compartment": "compartment_5460", "id": "reaction_10533044", "reactome": "R-CEL-1362408", "name": "FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10533037", "species_379721", "species_10533030" ], "products": [ "species_10533039", "species_379697", "species_10533041" ], "modifiers": [ [ "species_10533030", "catalyst" ], [ "species_10533037", "catalyst" ] ], "additional_components": [ "CHEBI:33738", "Q9NA32", "WBGene00013532", "Q9TY03", "WBGene00001486", "species_113531", "O61741", "WBGene00015021", "O45948", "WBGene00012885", "A0A2R8F5A8", "WBGene00302998", "Q9TY03", "WBGene00001486", "O61741", "WBGene00015021", "O45948", "WBGene00012885", "A0A2R8F5A8", "WBGene00302998", "CHEBI:33739", "CHEBI:33737", "Q9NA32", "WBGene00013532", "Q9TY03", "WBGene00001486", "species_113531", "O61741", "WBGene00015021", "O45948", "WBGene00012885", "A0A2R8F5A8", "WBGene00302998", "CHEBI:33738", "Q9NA32", "WBGene00013532" ] }, "reaction_10567878": { "compartment": "compartment_5460", "id": "reaction_10567878", "reactome": "R-CEL-8878815", "name": "Formation of 4Fe-4S cluster on ISCA1:ISCA2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10567869", "species_10567857" ], "products": [ "species_10567855", "species_10567871" ], "modifiers": [ [ "species_10567876", "catalyst" ] ], "additional_components": [ "A5HWB2", "WBGene00012666", "Q9XVZ9", "WBGene00013218", "CHEBI:33739", "Q9XTU9", "WBGene00013029", "WBGene00013029", "CHEBI:49883", "A5HWB2", "WBGene00012666", "Q9XVZ9", "WBGene00013218", "WBGene00001033" ] }, "reaction_10533049": { "compartment": "compartment_5460", "id": "reaction_10533049", "reactome": "R-CEL-1362416", "name": "Frataxin binds iron", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113531", "species_10533047" ], "products": [ "species_10533030" ], "modifiers": [], "additional_components": [ "Q9TY03", "WBGene00001486", "O61741", "WBGene00015021", "O45948", "WBGene00012885", "A0A2R8F5A8", "WBGene00302998", "Q9TY03", "WBGene00001486", "species_113531", "O61741", "WBGene00015021", "O45948", "WBGene00012885", "A0A2R8F5A8", "WBGene00302998" ] }, "reaction_10554321": { "compartment": "compartment_17963", "id": "reaction_10554321", "reactome": "R-CEL-5653873", "name": "SLC2A1 tetramer transports Glc from cytosol to Golgi lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70113" ], "products": [ "species_964746" ], "modifiers": [ [ "species_10554318", "catalyst" ] ], "additional_components": [ "Q21381", "WBGene00043980", "Q21382", "WBGene00043980", "Q21385", "WBGene00043980", "Q5WRR9", "WBGene00043980", "Q9GYQ1", "WBGene00043980", "Q9NEI8", "WBGene00043980" ] }, "reaction_10562084": { "compartment": "compartment_70101", "id": "reaction_10562084", "reactome": "R-CEL-6799495", "name": "GLYCTK phosphorylates DGA to 3PDGA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6799497", "species_113592" ], "products": [ "species_70106", "species_29370", "species_6799493" ], "modifiers": [ [ "species_10562081", "catalyst" ] ], "additional_components": [ "WBGene00015733" ] }, "reaction_10502888": { "compartment": "compartment_70101", "id": "reaction_10502888", "reactome": "R-CEL-70349", "name": "DAK dimer phosphorylates D-glyceraldehyde to form D-glyceraldehyde 3-phosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30393", "species_113592" ], "products": [ "species_29578", "species_29370" ], "modifiers": [ [ "species_10502885", "catalyst" ] ], "additional_components": [ "Q9N5C4", "WBGene00020962", "species_114632" ] }, "reaction_10502878": { "compartment": "compartment_70101", "id": "reaction_10502878", "reactome": "R-CEL-70342", "name": "ALDOB tetramer cleaves Fru-1-P to GA and DHAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_31221" ], "products": [ "species_30393", "species_75970" ], "modifiers": [ [ "species_10502875", "catalyst" ] ], "additional_components": [ "P54216", "WBGene00011474" ] }, "reaction_10554242": { "compartment": "compartment_70101", "id": "reaction_10554242", "reactome": "R-CEL-5652172", "name": "AKR1B1 reduces Glc to D-sorbitol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_70113" ], "products": [ "species_29366", "species_5652213" ], "modifiers": [ [ "species_10513654", "catalyst" ] ], "additional_components": [ "WBGene00016985" ] }, "reaction_10554254": { "compartment": "compartment_70101", "id": "reaction_10554254", "reactome": "R-CEL-5652195", "name": "SORD oxidizes D-sorbitol to Fru", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5652213", "species_29360" ], "products": [ "species_29532", "species_70106", "species_73473" ], "modifiers": [ [ "species_10554251", "catalyst" ] ], "additional_components": [ "species_216785", "Q21702", "WBGene00011003" ] }, "reaction_10502896": { "compartment": "compartment_70101", "id": "reaction_10502896", "reactome": "R-CEL-70361", "name": "GALT transfers UMP from UDP-Glc to Gal1P to form UDP-Gal", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30170", "species_29410" ], "products": [ "species_29452", "species_29548" ], "modifiers": [ [ "species_10502893", "catalyst" ] ], "additional_components": [ "WBGene00014203" ] }, "reaction_10502906": { "compartment": "compartment_70101", "id": "reaction_10502906", "reactome": "R-CEL-70369", "name": "GALE:NAD+ dimer reversibly epimerises UDP-Gal to UDP-Glc", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29452" ], "products": [ "species_29410" ], "modifiers": [ [ "species_10502903", "catalyst" ] ], "additional_components": [ "species_29360", "Q564Q1", "WBGene00008132" ] }, "reaction_10504192": { "compartment": "compartment_70101", "id": "reaction_10504192", "reactome": "R-CEL-71593", "name": "((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)glycogenin => poly{(1,4)-alpha-glucosyl} glycogenin + alpha-D-glucose", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10504148" ], "products": [ "species_10504189", "species_70113" ], "modifiers": [ [ "species_10504153", "catalyst" ] ], "additional_components": [ "G5ECZ5", "WBGene00011684", "H2KYQ5", "WBGene00006863", "O45819", "WBGene00012020", "species_266099", "G5ECZ5", "WBGene00011684", "H2KYQ5", "WBGene00006863", "O45819", "WBGene00012020", "species_266099", "WBGene00011050" ] }, "reaction_10526209": { "compartment": "compartment_70101", "id": "reaction_10526209", "reactome": "R-CEL-453342", "name": "PGYM dimer, b form + 2 AMP <=> PGYM b dimer:AMP complex", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10504012", "species_76577" ], "products": [ "species_10526195" ], "modifiers": [ [ "species_113592", "inhibitor" ], [ "species_30537", "inhibitor" ] ], "additional_components": [ "Q9N5U1", "WBGene00020696", "species_76577", "Q9N5U1", "WBGene00020696" ] }, "reaction_10504099": { "compartment": "compartment_70101", "id": "reaction_10504099", "reactome": "R-CEL-71541", "name": "glycogen phosphorylase (PYGM) dimer b + 2 ATP => glycogen phosphorylase (PYGM) dimer a + 2 ADP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10504012", "species_113592" ], "products": [ "species_29370", "species_10504017" ], "modifiers": [ [ "species_10504096", "catalyst" ], [ "species_74016", "catalyst" ] ], "additional_components": [ "Q9N5U1", "WBGene00020696", "Q9N5U1", "WBGene00020696", "Q9N3L4", "WBGene00021753", "P34335", "WBGene00015754", "H2L0I6", "WBGene00022059", "Q11083", "WBGene00020378", "P04630", "WBGene00000285", "G5EF37", "WBGene00003934", "A0A2C9C3L3", "WBGene00020378", "Q18136", "WBGene00006861", "Q09665", "WBGene00006583", "O02159", "WBGene00020378", "G5EDZ8", "WBGene00000288", "Q94288", "WBGene00000287", "Q09980", "WBGene00017394", "O16305", "WBGene00000552", "G5EEG0", "WBGene00000286" ] }, "reaction_10504156": { "compartment": "compartment_70101", "id": "reaction_10504156", "reactome": "R-CEL-71552", "name": "limit dextrin-glycogenin => ((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl) glycogenin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10504128" ], "products": [ "species_10504148" ], "modifiers": [ [ "species_10504153", "catalyst" ] ], "additional_components": [ "H2KYQ5", "WBGene00006863", "species_266099", "G5ECZ5", "WBGene00011684", "O45819", "WBGene00012020", "G5ECZ5", "WBGene00011684", "H2KYQ5", "WBGene00006863", "O45819", "WBGene00012020", "species_266099", "WBGene00011050" ] }, "reaction_10503904": { "compartment": "compartment_70101", "id": "reaction_10503904", "reactome": "R-CEL-71299", "name": "6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29996", "species_29366" ], "products": [ "species_70106", "species_113528", "species_29364", "species_29732" ], "modifiers": [ [ "species_10503901", "catalyst" ] ], "additional_components": [ "Q17761", "WBGene00012015" ] }, "reaction_10570503": { "compartment": "compartment_70101", "id": "reaction_10570503", "reactome": "R-CEL-8982667", "name": "PGM2:Mg2+ isomerises dR1P to dR5P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6787326" ], "products": [ "species_6787328" ], "modifiers": [ [ "species_10502849", "catalyst" ] ], "additional_components": [ "species_114632", "O45934", "WBGene00012803" ] }, "reaction_10569995": { "compartment": "compartment_70101", "id": "reaction_10569995", "reactome": "R-CEL-8955844", "name": "RBKS phosphorylates ribose to R5P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_8955853" ], "products": [ "species_73578", "species_29370" ], "modifiers": [ [ "species_10569992", "catalyst" ] ], "additional_components": [ "WBGene00008548" ] }, "reaction_10558222": { "compartment": "compartment_70101", "id": "reaction_10558222", "reactome": "R-CEL-6787321", "name": "DERA cleaves dR5P to GA3P and CH3CHO", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6787328" ], "products": [ "species_29578", "species_29510" ], "modifiers": [ [ "species_10558219", "catalyst" ] ], "additional_components": [ "WBGene00017283" ] }, "reaction_10558225": { "compartment": "compartment_70101", "id": "reaction_10558225", "reactome": "R-CEL-6787329", "name": "PGM2:Mg2+ isomerises R1P to R5P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_112016" ], "products": [ "species_73578" ], "modifiers": [ [ "species_10502849", "catalyst" ] ], "additional_components": [ "species_114632", "O45934", "WBGene00012803" ] }, "reaction_10503924": { "compartment": "compartment_70101", "id": "reaction_10503924", "reactome": "R-CEL-71303", "name": "RPE dimers isomerise RU5P to XY5P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29732" ], "products": [ "species_29790" ], "modifiers": [ [ "species_10503921", "catalyst" ] ], "additional_components": [ "Q95ZW2", "WBGene00017272", "species_113531" ] }, "reaction_10506066": { "compartment": "compartment_70101", "id": "reaction_10506066", "reactome": "R-CEL-73580", "name": "D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73578", "species_113592" ], "products": [ "species_73566", "species_76577" ], "modifiers": [ [ "species_10506063", "catalyst" ] ], "additional_components": [ "Q6AHR3", "WBGene00020107" ] }, "reaction_10508824": { "compartment": "compartment_70101", "id": "reaction_10508824", "reactome": "R-CEL-111215", "name": "D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73578", "species_110644" ], "products": [ "species_73566", "species_109386" ], "modifiers": [ [ "species_10506063", "catalyst" ], [ "species_29926", "catalyst" ], [ "species_29372", "catalyst" ] ], "additional_components": [ "Q6AHR3", "WBGene00020107" ] }, "reaction_10512117": { "compartment": "compartment_70101", "id": "reaction_10512117", "reactome": "R-CEL-177784", "name": "ribose 5-phosphate <=> D-ribulose 5-phosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73578" ], "products": [ "species_29732" ], "modifiers": [ [ "species_10503929", "catalyst" ] ], "additional_components": [ "WBGene00015101" ] }, "reaction_10503894": { "compartment": "compartment_70101", "id": "reaction_10503894", "reactome": "R-CEL-71296", "name": "D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_31467" ], "products": [ "species_29996" ], "modifiers": [ [ "species_10503891", "catalyst" ] ], "additional_components": [ "WBGene00013301" ] }, "reaction_10514364": { "compartment": "compartment_70101", "id": "reaction_10514364", "reactome": "R-CEL-199803", "name": "xylulose 5-phosphate <=> D-ribulose 5-phosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29790" ], "products": [ "species_29732" ], "modifiers": [ [ "species_10503921", "catalyst" ] ], "additional_components": [ "Q95ZW2", "WBGene00017272", "species_113531" ] }, "reaction_10570173": { "compartment": "compartment_70101", "id": "reaction_10570173", "reactome": "R-CEL-8959719", "name": "SHPK phosphorylates Sedo to Sedo7P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_8959707" ], "products": [ "species_70106", "species_29370", "species_29882" ], "modifiers": [ [ "species_10570170", "catalyst" ] ], "additional_components": [ "WBGene00012017" ] }, "reaction_10503076": { "compartment": "compartment_70101", "id": "reaction_10503076", "reactome": "R-CEL-70479", "name": "D-fructose 1,6-bisphosphate + H2O => D-fructose 6-phosphate + orthophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30014", "species_29356" ], "products": [ "species_29372", "species_29512" ], "modifiers": [ [ "species_10503073", "catalyst" ], [ "species_76577", "inhibitor" ] ], "additional_components": [ "species_114632", "G5EBJ7", "WBGene00001404" ] }, "reaction_10513893": { "compartment": "compartment_70101", "id": "reaction_10513893", "reactome": "R-CEL-198508", "name": "malate + NAD+ <=> oxaloacetate + NADH + H+", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_198498", "species_29360" ], "products": [ "species_70106", "species_76213", "species_73473" ], "modifiers": [ [ "species_10513890", "catalyst" ] ], "additional_components": [ "Q9UAV5", "WBGene00018491" ] }, "reaction_10502823": { "compartment": "compartment_70101", "id": "reaction_10502823", "reactome": "R-CEL-70241", "name": "oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [cytosol]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_76213" ], "products": [ "species_29420", "species_113528", "species_29492" ], "modifiers": [ [ "species_10502820", "catalyst" ] ], "additional_components": [ "Q9TYQ8", "WBGene00019151", "O02286", "WBGene00011232", "O44906", "WBGene00021043" ] }, "reaction_10519528": { "compartment": "compartment_70101", "id": "reaction_10519528", "reactome": "R-CEL-376851", "name": "Exchange of alpha-ketoglutarate (2-oxoglutarate) and malate across the inner mitochondrial membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113594", "species_198498" ], "products": [ "species_29406", "species_113544" ], "modifiers": [ [ "species_10513880", "catalyst" ] ], "additional_components": [ "P90992", "WBGene00015186" ] }, "reaction_10513901": { "compartment": "compartment_70101", "id": "reaction_10513901", "reactome": "R-CEL-198513", "name": "Cytosolic glucose 6-phosphate is exchanged for orthophosphate from the endoplasmic reticulum lumen by SLC37A4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113551", "species_30537" ], "products": [ "species_29372", "species_113782" ], "modifiers": [ [ "species_10513898", "catalyst" ] ], "additional_components": [ "WBGene00302978" ] }, "reaction_10518414": { "compartment": "compartment_5460", "id": "reaction_10518414", "reactome": "R-CEL-372819", "name": "oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [mitochondrial matrix]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113573", "species_113587" ], "products": [ "species_372364", "species_113525", "species_29376" ], "modifiers": [ [ "species_10518411", "catalyst" ] ], "additional_components": [ "WBGene00011232" ] }, "reaction_10503122": { "compartment": "compartment_5460", "id": "reaction_10503122", "reactome": "R-CEL-70501", "name": "Pyruvate + CO2 + ATP => ADP + Orthophosphate + Oxaloacetate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113593", "species_113557", "species_29376" ], "products": [ "species_113548", "species_113581", "species_113587" ], "modifiers": [ [ "species_10503119", "catalyst" ], [ "species_113559", "catalyst" ] ], "additional_components": [ "species_266099", "O17732", "WBGene00004258", "species_199207" ] }, "reaction_10518291": { "compartment": "compartment_70101", "id": "reaction_10518291", "reactome": "R-CEL-372449", "name": "phosphoenolpyruvate [mitochondrial matrix] + citrate [cytosol] => phosphoenolpyruvate [cytosol] + citrate [mitochondrial matrix]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76190", "species_372364" ], "products": [ "species_29654", "species_29492" ], "modifiers": [ [ "species_10507389", "catalyst" ] ], "additional_components": [ "WBGene00010780" ] }, "reaction_10518422": { "compartment": "compartment_70101", "id": "reaction_10518422", "reactome": "R-CEL-372843", "name": "malate [mitochondrial matrix] + orthophosphate [cytosol] <=> malate [cytosol] + orthophosphate [mitochondrial matrix]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29372", "species_113544" ], "products": [ "species_113548", "species_198498" ], "modifiers": [ [ "species_10518419", "catalyst" ] ], "additional_components": [ "WBGene00019656" ] }, "reaction_10513883": { "compartment": "compartment_70101", "id": "reaction_10513883", "reactome": "R-CEL-198440", "name": "malate [mitochondrial matrix] + alpha-ketoglutarate [cytosol] <=> malate [cytosol] + alpha-ketoglutarate [mitochondrial matrix]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29406", "species_113544" ], "products": [ "species_113594", "species_198498" ], "modifiers": [ [ "species_10513880", "catalyst" ] ], "additional_components": [ "P90992", "WBGene00015186" ] }, "reaction_10571905": { "compartment": "compartment_17963", "id": "reaction_10571905", "reactome": "R-CEL-9603986", "name": "FUT3 transfers Fuc to Type 1 chains to form LeA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9036984", "species_205683" ], "products": [ "species_205689", "species_9605607" ], "modifiers": [ [ "species_10557156", "catalyst" ] ], "additional_components": [ "WBGene00016163" ] }, "reaction_10571890": { "compartment": "compartment_17963", "id": "reaction_10571890", "reactome": "R-CEL-9603982", "name": "FUT2 transfers Fuc to LeA to form LeB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9605607", "species_205683" ], "products": [ "species_205689", "species_9605394" ], "modifiers": [ [ "species_10571827", "catalyst" ] ], "additional_components": [ "WBGene00015019" ] }, "reaction_10571973": { "compartment": "compartment_17963", "id": "reaction_10571973", "reactome": "R-CEL-9605682", "name": "FUT3,5,6,7 transfers Fuc to Type 2 MSGG to form sLeX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9605685", "species_205683" ], "products": [ "species_9605661", "species_205689" ], "modifiers": [ [ "species_10571970", "catalyst" ] ], "additional_components": [ "Q18255", "WBGene00016163" ] }, "reaction_10571892": { "compartment": "compartment_17963", "id": "reaction_10571892", "reactome": "R-CEL-9603983", "name": "FUT2 transfers Fuc to LeX to form LeY", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9605593", "species_205683" ], "products": [ "species_205689", "species_9605586" ], "modifiers": [ [ "species_10571827", "catalyst" ] ], "additional_components": [ "WBGene00015019" ] }, "reaction_10571946": { "compartment": "compartment_17963", "id": "reaction_10571946", "reactome": "R-CEL-9603989", "name": "B3GALTs transfer Gal to GlcNAc-1,3-Gal-R to form Type 1 chain", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9604808", "species_735682" ], "products": [ "species_205687", "species_9036984" ], "modifiers": [ [ "species_10571943", "catalyst" ] ], "additional_components": [ "Q95US5", "WBGene00000270", "Q9XU74", "WBGene00011780", "G5EDB3", "WBGene00044630", "G5ECA6", "WBGene00011780", "H2L0F4", "WBGene00044618", "O02231", "WBGene00011780", "O02310", "WBGene00011780", "O17750", "WBGene00011780", "O62114", "WBGene00011780", "O62115", "WBGene00011780", "O62163", "WBGene00011780", "O62165", "WBGene00011780", "O62375", "WBGene00011780", "Q20575", "WBGene00011780", "Q6QMT2", "WBGene00000267", "Q8MQG4", "WBGene00011780" ] }, "reaction_10571964": { "compartment": "compartment_17963", "id": "reaction_10571964", "reactome": "R-CEL-9605609", "name": "FUT3 transfers Fuc to Type 1 MSGG to form sLeA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9605595", "species_205683" ], "products": [ "species_9605615", "species_205689" ], "modifiers": [ [ "species_10557156", "catalyst" ] ], "additional_components": [ "WBGene00016163" ] }, "reaction_10571903": { "compartment": "compartment_17963", "id": "reaction_10571903", "reactome": "R-CEL-9603984", "name": "FUT4,5,9,(10,11) transfer Fuc to Type 2 chains to form LeX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9033790", "species_205683" ], "products": [ "species_9605593", "species_205689" ], "modifiers": [ [ "species_10571900", "catalyst" ] ], "additional_components": [ "Q18255", "WBGene00016163" ] }, "reaction_10571966": { "compartment": "compartment_17963", "id": "reaction_10571966", "reactome": "R-CEL-9605644", "name": "FUT3 transfers Fuc to Type 1 DSGG to form dsLeA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9605649", "species_205683" ], "products": [ "species_205689", "species_9605651" ], "modifiers": [ [ "species_10557156", "catalyst" ] ], "additional_components": [ "WBGene00016163" ] }, "reaction_10510218": { "compartment": "compartment_7660", "id": "reaction_10510218", "reactome": "R-CEL-163664", "name": "AMP binds to gamma subunit of AMP kinase heterotrimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_164121", "species_10510212" ], "products": [ "species_10510216" ], "modifiers": [], "additional_components": [ "Q9N501", "WBGene00021527", "A0A1T5HUK9", "WBGene00013732", "H2L0K0", "WBGene00020135", "O02168", "WBGene00020633", "Q95ZQ4", "WBGene00020142", "Q9XUY2", "WBGene00010115", "Q9N501", "WBGene00021527", "A0A1T5HUK9", "WBGene00013732", "H2L0K0", "WBGene00020135", "O02168", "WBGene00020633", "species_76577", "Q95ZQ4", "WBGene00020142", "Q9XUY2", "WBGene00010115" ] }, "reaction_10517761": { "compartment": "compartment_876", "id": "reaction_10517761", "reactome": "R-CEL-265645", "name": "Calcium Influx through Voltage-gated Calcium Channels", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74112" ], "products": [ "species_74016" ], "modifiers": [ [ "species_10517758", "catalyst" ] ], "additional_components": [ "G5EG74", "WBGene00007041", "P34374", "WBGene00006772", "Q8MQA1", "WBGene00001187", "A0A3B1E663", "WBGene00006742" ] }, "reaction_10527093": { "compartment": "compartment_876", "id": "reaction_10527093", "reactome": "R-CEL-499981", "name": "Transport of Extracellular Glucose to the Cytosol by GLUT1 and GLUT2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70115" ], "products": [ "species_70113" ], "modifiers": [ [ "species_10527090", "catalyst" ] ], "additional_components": [ "Q23626", "WBGene00022014", "Q95QY6", "WBGene00022014", "Q9GPA2", "WBGene00022014", "Q9N309", "WBGene00022014", "Q9U2K5", "WBGene00022014", "Q9XU83", "WBGene00022014", "Q9XVL3", "WBGene00022014", "G5EC93", "WBGene00022014", "O16547", "WBGene00022014", "O44616", "WBGene00022014", "O44827", "WBGene00019207", "O45920", "WBGene00022014", "Q11114", "WBGene00022014", "Q19376", "WBGene00022014", "Q20734", "WBGene00022014", "Q23535", "WBGene00006865", "Q21381", "WBGene00043980", "Q9GYQ1", "WBGene00043980", "Q21382", "WBGene00043980", "Q9NEI8", "WBGene00043980", "Q21385", "WBGene00043980", "Q5WRR9", "WBGene00043980" ] }, "reaction_10510248": { "compartment": "compartment_7660", "id": "reaction_10510248", "reactome": "R-CEL-163743", "name": "Transcriptional activation of Acetyl-CoA carboxylase by ChREBP:MLX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [], "products": [ "species_10510246" ], "modifiers": [ [ "species_10510237", "catalyst" ] ], "additional_components": [ "Q9XUC3", "WBGene00012131", "H2L0M0", "WBGene00004076", "P41846", "WBGene00003378", "Q9TZ70", "WBGene00003510" ] }, "reaction_10510250": { "compartment": "compartment_7660", "id": "reaction_10510250", "reactome": "R-CEL-163748", "name": "Transcriptional activation of GP-acyl transferase gene by ChREBP:MLX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [], "products": [ "species_10507496" ], "modifiers": [ [ "species_10510237", "catalyst" ] ], "additional_components": [ "Q22267", "WBGene00011543", "Q93841", "WBGene00010339", "P41846", "WBGene00003378", "Q9TZ70", "WBGene00003510" ] }, "reaction_10510239": { "compartment": "compartment_7660", "id": "reaction_10510239", "reactome": "R-CEL-163733", "name": "Transcriptional activation of FAS monomer gene by ChREBP:MLX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [], "products": [ "species_10507450" ], "modifiers": [ [ "species_10510237", "catalyst" ] ], "additional_components": [ "WBGene00009342", "P41846", "WBGene00003378", "Q9TZ70", "WBGene00003510" ] }, "reaction_10568065": { "compartment": "compartment_70101", "id": "reaction_10568065", "reactome": "R-CEL-8932851", "name": "PQLC2 transports L-Arg,L-His,L-Lys from lysosomal lumen to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8932838" ], "products": [ "species_8932842" ], "modifiers": [ [ "species_10568062", "catalyst" ] ], "additional_components": [ "species_29612", "species_29444", "species_29468", "species_29468", "species_29612", "species_29444", "WBGene00021546" ] }, "reaction_10551456": { "compartment": "compartment_70101", "id": "reaction_10551456", "reactome": "R-CEL-5336453", "name": "NIPAs transport Mg2+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_114632" ], "products": [ "species_29926" ], "modifiers": [ [ "species_10551447", "catalyst" ] ], "additional_components": [ "WBGene00021820" ] }, "reaction_10551488": { "compartment": "compartment_70101", "id": "reaction_10551488", "reactome": "R-CEL-5340130", "name": "CTNS cotransports CySS-, H+ from lysosomal lumen to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428040", "species_5673778" ], "products": [ "species_70106", "species_379444" ], "modifiers": [ [ "species_10551485", "catalyst" ] ], "additional_components": [ "WBGene00008052" ] }, "reaction_10550773": { "compartment": "compartment_70101", "id": "reaction_10550773", "reactome": "R-CEL-5226999", "name": "ADD1:ADD3 binds DMTN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10550757", "species_10550769" ], "products": [ "species_10550771" ], "modifiers": [], "additional_components": [ "WBGene00006839", "Q20952", "WBGene00000073", "Q9U9K0", "WBGene00000072", "Q20952", "WBGene00000073", "Q9U9K0", "WBGene00000072", "Q95QM5", "WBGene00006839" ] }, "reaction_10550761": { "compartment": "compartment_70101", "id": "reaction_10550761", "reactome": "R-CEL-5226979", "name": "ADD1:ADD2 binds DMTN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10550757", "species_10550752" ], "products": [ "species_10550759" ], "modifiers": [], "additional_components": [ "WBGene00006839", "Q20952", "WBGene00000073", "Q9U9K0", "WBGene00000072", "Q20952", "WBGene00000073", "Q9U9K0", "WBGene00000072", "Q95QM5", "WBGene00006839" ] }, "reaction_10551480": { "compartment": "compartment_70101", "id": "reaction_10551480", "reactome": "R-CEL-5339538", "name": "MAGT1 transports Mg2+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_114632" ], "products": [ "species_29926" ], "modifiers": [ [ "species_10551477", "catalyst" ] ], "additional_components": [ "WBGene00022793" ] }, "reaction_10551467": { "compartment": "compartment_70101", "id": "reaction_10551467", "reactome": "R-CEL-5339528", "name": "TUSC3 transports Mg2+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_114632" ], "products": [ "species_29926" ], "modifiers": [ [ "species_10551464", "catalyst" ] ], "additional_components": [ "WBGene00022793" ] }, "reaction_10509864": { "compartment": "compartment_7660", "id": "reaction_10509864", "reactome": "R-CEL-156678", "name": "Activation of Cdc25C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10509856" ], "products": [ "species_29370", "species_10509859" ], "modifiers": [ [ "species_10509861", "catalyst" ] ], "additional_components": [ "WBGene00000389", "WBGene00000389", "WBGene00004043" ] }, "reaction_10510078": { "compartment": "compartment_7660", "id": "reaction_10510078", "reactome": "R-CEL-162657", "name": "Inactivation of Myt1 kinase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10510073" ], "products": [ "species_113582", "species_10510076" ], "modifiers": [ [ "species_10509851", "catalyst" ] ], "additional_components": [ "WBGene00006940", "WBGene00006940", "WBGene00004043" ] }, "reaction_10555392": { "compartment": "compartment_70101", "id": "reaction_10555392", "reactome": "R-CEL-5678863", "name": "CFTR transports Cl- from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_352022" ], "products": [ "species_188972", "species_29372", "species_29370" ], "modifiers": [ [ "species_10520442", "catalyst" ] ], "additional_components": [ "Q19625", "WBGene00003412", "Q95QV2", "WBGene00000477" ] }, "reaction_10534309": { "compartment": "compartment_70101", "id": "reaction_10534309", "reactome": "R-CEL-1454916", "name": "The ABCC family mediates organic anion transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_1454930" ], "products": [ "species_29372", "species_29370", "species_1454919" ], "modifiers": [ [ "species_10534306", "catalyst" ] ], "additional_components": [ "G5EE72", "WBGene00003411", "Q19625", "WBGene00003412", "Q95QV2", "WBGene00000477", "Q3S1M2", "WBGene00003407", "Q20943", "WBGene00003408", "G5EFP3", "WBGene00003410", "Q9U2G5", "WBGene00003413", "Q19048", "WBGene00003409", "Q9XW61", "WBGene00003414" ] }, "reaction_10566312": { "compartment": "compartment_12045", "id": "reaction_10566312", "reactome": "R-CEL-8866542", "name": "VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_10566310" ], "products": [ "species_10566284", "species_29372", "species_29370", "species_10566308" ], "modifiers": [], "additional_components": [ "Q93561", "WBGene00000843", "A3QMC6", "WBGene00016592", "G5EFG0", "WBGene00004759", "Q09396", "WBGene00018611", "Q9NF22", "WBGene00013667", "Q09463", "WBGene00004381", "P54812", "WBGene00008053", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "Q19625", "WBGene00003412", "Q95QV2", "WBGene00000477", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "Q19625", "WBGene00003412", "Q95QV2", "WBGene00000477", "Q93561", "WBGene00000843", "A3QMC6", "WBGene00016592", "G5EFG0", "WBGene00004759", "Q09396", "WBGene00018611", "Q9NF22", "WBGene00013667", "Q09463", "WBGene00004381", "P54812", "WBGene00008053" ] }, "reaction_10517776": { "compartment": "compartment_876", "id": "reaction_10517776", "reactome": "R-CEL-265783", "name": "ABCG5:ABCG8 transports sterols from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_265784", "species_113592" ], "products": [ "species_29372", "species_29370", "species_265781" ], "modifiers": [ [ "species_10517773", "catalyst" ] ], "additional_components": [ "CHEBI:26125", "species_193384", "CHEBI:26125", "species_193384", "Q18900", "WBGene00016973", "D7SFK1", "WBGene00006522" ] }, "reaction_10520430": { "compartment": "compartment_17947", "id": "reaction_10520430", "reactome": "R-CEL-382613", "name": "PEX-19 docks ABCD1/D2/D3 to peroximal membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10520428", "species_10520404" ], "products": [ "species_10520396", "species_10520426", "species_10520404" ], "modifiers": [], "additional_components": [ "O45730", "WBGene00004061", "Q18598", "WBGene00004059", "P34453", "WBGene00004201", "WBGene00004193", "O45730", "WBGene00004061", "Q18598", "WBGene00004059", "WBGene00004201", "WBGene00004193" ] }, "reaction_10520399": { "compartment": "compartment_17947", "id": "reaction_10520399", "reactome": "R-CEL-382575", "name": "ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_382577" ], "products": [ "species_382571", "species_29372", "species_29370" ], "modifiers": [ [ "species_10520396", "catalyst" ] ], "additional_components": [ "O45730", "WBGene00004061", "Q18598", "WBGene00004059" ] }, "reaction_10550732": { "compartment": "compartment_70101", "id": "reaction_10550732", "reactome": "R-CEL-5223317", "name": "ABCB9 transports peptides from cytosol to lysosomal lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_5223341" ], "products": [ "species_5223344", "species_29372", "species_29370" ], "modifiers": [ [ "species_10550729", "catalyst" ] ], "additional_components": [ "O02086", "WBGene00001812" ] }, "reaction_10566317": { "compartment": "compartment_12045", "id": "reaction_10566317", "reactome": "R-CEL-8866546", "name": "RNF5 and RNF185 ubiquitinate misfolded CFTR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10566314", "species_10502375" ], "products": [ "species_10566310" ], "modifiers": [ [ "species_10566314", "catalyst" ] ], "additional_components": [ "Q93561", "WBGene00000843", "A3QMC6", "WBGene00016592", "G5EFG0", "WBGene00004759", "Q09396", "WBGene00018611", "Q9NF22", "WBGene00013667", "Q09463", "WBGene00004381", "P54812", "WBGene00008053", "Q19625", "WBGene00003412", "Q95QV2", "WBGene00000477", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "Q93561", "WBGene00000843", "A3QMC6", "WBGene00016592", "G5EFG0", "WBGene00004759", "Q09396", "WBGene00018611", "Q9NF22", "WBGene00013667", "Q09463", "WBGene00004381", "P54812", "WBGene00008053", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "Q19625", "WBGene00003412", "Q95QV2", "WBGene00000477", "Q93561", "WBGene00000843", "A3QMC6", "WBGene00016592", "G5EFG0", "WBGene00004759", "Q09396", "WBGene00018611", "Q9NF22", "WBGene00013667", "Q09463", "WBGene00004381", "P54812", "WBGene00008053", "Q19625", "WBGene00003412", "Q95QV2", "WBGene00000477" ] }, "reaction_10520374": { "compartment": "compartment_70616", "id": "reaction_10520374", "reactome": "R-CEL-382560", "name": "ABC7, mABC1 and mABC2 mediate heme transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113593", "species_189444", "species_113521" ], "products": [ "species_113548", "species_113581", "species_71185" ], "modifiers": [ [ "species_10520371", "catalyst" ] ], "additional_components": [ "G4SRS5", "WBGene00022281" ] }, "reaction_10533110": { "compartment": "compartment_17906", "id": "reaction_10533110", "reactome": "R-CEL-1369065", "name": "ABCB6 transports porphyrin from cytosol to mitchondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1369066", "species_29356", "species_113592" ], "products": [ "species_29372", "species_29370", "species_1369027" ], "modifiers": [ [ "species_10533107", "catalyst" ] ], "additional_components": [ "G5EFD4", "WBGene00001815" ] }, "reaction_10566319": { "compartment": "compartment_12045", "id": "reaction_10566319", "reactome": "R-CEL-8866551", "name": "CFTR binds components of the ERAD machinery for ubiquitination and degradation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10566282", "species_10566308" ], "products": [ "species_10566314" ], "modifiers": [], "additional_components": [ "Q19625", "WBGene00003412", "Q95QV2", "WBGene00000477", "Q93561", "WBGene00000843", "A3QMC6", "WBGene00016592", "G5EFG0", "WBGene00004759", "Q09396", "WBGene00018611", "Q9NF22", "WBGene00013667", "Q09463", "WBGene00004381", "P54812", "WBGene00008053", "Q93561", "WBGene00000843", "A3QMC6", "WBGene00016592", "G5EFG0", "WBGene00004759", "Q09396", "WBGene00018611", "Q9NF22", "WBGene00013667", "Q09463", "WBGene00004381", "P54812", "WBGene00008053", "Q19625", "WBGene00003412", "Q95QV2", "WBGene00000477" ] }, "reaction_10566321": { "compartment": "compartment_70101", "id": "reaction_10566321", "reactome": "R-CEL-8866553", "name": "misfolded CFTR is degraded by the 26S proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10566284" ], "products": [ "species_10502375" ], "modifiers": [ [ "species_10502572", "catalyst" ] ], "additional_components": [ "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "Q19625", "WBGene00003412", "Q95QV2", "WBGene00000477", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "P91477", "WBGene00003950", "Q95PZ7", "WBGene00013435", "Q18115", "WBGene00004459", "O62102", "WBGene00003948", "O17071", "WBGene00004504", "Q10920", "WBGene00016623", "P34286", "WBGene00003952", "Q9XTT9", "WBGene00004506", "Q23449", "WBGene00004468", "Q95005", "WBGene00003925", "P46502", "WBGene00004503", "O61792", "WBGene00004464", "O17586", "WBGene00003922", "O76371", "WBGene00004505", "Q20585", "WBGene00004463", "Q95008", "WBGene00003926", "Q18787", "WBGene00004501", "Q20058", "WBGene00009445", "Q9N599", "WBGene00003924", "O16368", "WBGene00004502", "O61742", "WBGene00004466", "Q09583", "WBGene00003928", "Q966I8", "WBGene00003947", "Q04908", "WBGene00004460", "Q9XUV0", "WBGene00003951", "Q27488", "WBGene00003923", "Q9GZH5", "WBGene00004458", "O44156", "WBGene00003927", "Q22253", "WBGene00004465", "O76577", "WBGene00004467", "P90868", "WBGene00003953", "Q19324", "WBGene00004461", "Q17971", "WBGene00007588", "Q23237", "WBGene00003949", "Q20938", "WBGene00004462" ] }, "reaction_10534322": { "compartment": "compartment_876", "id": "reaction_10534322", "reactome": "R-CEL-1467457", "name": "ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_1131652" ], "products": [ "species_29372", "species_29370", "species_1467459" ], "modifiers": [ [ "species_10534319", "catalyst" ] ], "additional_components": [ "P34712", "WBGene00003995", "G5EG58", "WBGene00004003" ] }, "reaction_10555389": { "compartment": "compartment_984", "id": "reaction_10555389", "reactome": "R-CEL-5678706", "name": "ABCB4 transports PC from plasma membrane to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_429802", "species_113592" ], "products": [ "species_382539", "species_29372", "species_29370" ], "modifiers": [ [ "species_10555386", "catalyst" ] ], "additional_components": [ "G5EG58", "WBGene00004003", "P34712", "WBGene00003995" ] }, "reaction_10566333": { "compartment": "compartment_876", "id": "reaction_10566333", "reactome": "R-CEL-8866851", "name": "CFTR transits to the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10566282" ], "products": [ "species_10520442" ], "modifiers": [], "additional_components": [ "Q19625", "WBGene00003412", "Q95QV2", "WBGene00000477", "Q19625", "WBGene00003412", "Q95QV2", "WBGene00000477" ] }, "reaction_10520445": { "compartment": "compartment_876", "id": "reaction_10520445", "reactome": "R-CEL-383190", "name": "HCO3- transport through ion channel", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_111627", "species_113592" ], "products": [ "species_29372", "species_29370", "species_425425" ], "modifiers": [ [ "species_10520442", "catalyst" ] ], "additional_components": [ "Q19625", "WBGene00003412", "Q95QV2", "WBGene00000477" ] }, "reaction_10550782": { "compartment": "compartment_70101", "id": "reaction_10550782", "reactome": "R-CEL-5227009", "name": "ABCF1 binds EIF2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10505631", "species_10550778" ], "products": [ "species_10550780" ], "modifiers": [], "additional_components": [ "Q9BKU3", "WBGene00021351", "Q21230", "WBGene00010560", "Q95XR0", "WBGene00021466", "WBGene00006512", "Q19554", "WBGene00006512", "Q9BKU3", "WBGene00021351", "Q21230", "WBGene00010560", "Q95XR0", "WBGene00021466" ] }, "reaction_10518493": { "compartment": "compartment_70101", "id": "reaction_10518493", "reactome": "R-CEL-373705", "name": "Caspase cleavage of DCC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10518486" ], "products": [ "species_10518490", "species_10518488" ], "modifiers": [ [ "species_10509422", "catalyst" ] ], "additional_components": [ "P42573", "WBGene00000417" ] }, "reaction_10556804": { "compartment": "compartment_70101", "id": "reaction_10556804", "reactome": "R-CEL-5691108", "name": "SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502375", "species_10556692" ], "products": [ "species_10556795" ], "modifiers": [ [ "species_10556801", "catalyst" ] ], "additional_components": [ "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "WBGene00000040", "WBGene00000040", "Q93725", "WBGene00003587", "G5ECU1", "WBGene00004807", "Q17389", "WBGene00000836" ] }, "reaction_10535239": { "compartment": "compartment_70101", "id": "reaction_10535239", "reactome": "R-CEL-1562626", "name": "Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_71067", "species_29368" ], "products": [ "species_5691103" ], "modifiers": [ [ "species_10535236", "catalyst" ] ], "additional_components": [ "O16453", "WBGene00001500", "Q9TYS3", "WBGene00001501" ] }, "reaction_10556813": { "compartment": "compartment_70101", "id": "reaction_10556813", "reactome": "R-CEL-5691131", "name": "CANDI binds CUL1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10516329", "species_10556809" ], "products": [ "species_10556811" ], "modifiers": [], "additional_components": [ "WBGene00000836", "WBGene00013606", "G5ED41", "WBGene00013606", "Q17389", "WBGene00000836" ] }, "reaction_10529202": { "compartment": "compartment_984", "id": "reaction_10529202", "reactome": "R-CEL-917805", "name": "CYBRD1:Heme reduces Fe3+ to Fe2+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_917828", "species_912516" ], "products": [ "species_435347" ], "modifiers": [ [ "species_10529199", "catalyst" ] ], "additional_components": [ "species_71185", "O16271", "WBGene00018210" ] }, "reaction_10556690": { "compartment": "compartment_70101", "id": "reaction_10556690", "reactome": "R-CEL-5690873", "name": "ACO1 binds 4Fe-4S", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10556686", "species_5690881" ], "products": [ "species_10556688" ], "modifiers": [], "additional_components": [ "WBGene00000040", "Q23500", "WBGene00000040" ] }, "reaction_10556695": { "compartment": "compartment_70101", "id": "reaction_10556695", "reactome": "R-CEL-5690911", "name": "ACO1:4Fe-4S isomerises CIT to ISCIT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76190" ], "products": [ "species_389545" ], "modifiers": [ [ "species_10556688", "catalyst" ] ], "additional_components": [ "Q23500", "WBGene00000040" ] }, "reaction_10556792": { "compartment": "compartment_5460", "id": "reaction_10556792", "reactome": "R-CEL-5691107", "name": "FTMT 24mer oxidises 4Fe2+ to 4Fe(3+)O(OH)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113533", "species_113531", "species_113529" ], "products": [ "species_5691135" ], "modifiers": [ [ "species_10556789", "catalyst" ] ], "additional_components": [ "Q9TYS3", "WBGene00001501", "O16453", "WBGene00001500" ] }, "reaction_10529210": { "compartment": "compartment_947586", "id": "reaction_10529210", "reactome": "R-CEL-917891", "name": "SLC40A1:CP:6Cu2+ oxidises Fe2+ to Fe3+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_435347", "species_352327" ], "products": [ "species_109276", "species_912516" ], "modifiers": [ [ "species_10528427", "catalyst" ] ], "additional_components": [ "Q19687", "WBGene00009008", "species_209799", "O44607", "WBGene00019977", "Q8IA95", "WBGene00021354" ] }, "reaction_10529213": { "compartment": "compartment_947586", "id": "reaction_10529213", "reactome": "R-CEL-917933", "name": "SLC40A1:HEPH:6Cu2+ oxidises 4Fe2+ to 4Fe3+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_435347", "species_352327" ], "products": [ "species_109276", "species_912516" ], "modifiers": [ [ "species_10524363", "catalyst" ] ], "additional_components": [ "O44607", "WBGene00019977", "Q8IA95", "WBGene00021354", "CHEBI:28694", "Q19687", "WBGene00009008" ] }, "reaction_10534717": { "compartment": "compartment_70101", "id": "reaction_10534717", "reactome": "R-CEL-1475435", "name": "CA1:Zn2+,CA2:Zn2+ hydrate CO2 to HCO3-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113528" ], "products": [ "species_70106", "species_111627" ], "modifiers": [ [ "species_10534714", "catalyst" ] ], "additional_components": [ "O02637", "WBGene00000284", "Q10462", "WBGene00000283", "Q21614", "WBGene00000282", "Q27504", "WBGene00000281", "species_216785" ] }, "reaction_10570305": { "compartment": "compartment_70101", "id": "reaction_10570305", "reactome": "R-CEL-8981570", "name": "GLUT4 (SLC2A4) tetramer transports Glc from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70115" ], "products": [ "species_70113" ], "modifiers": [ [ "species_10570302", "catalyst" ] ], "additional_components": [ "O44827", "WBGene00019207" ] }, "reaction_10551459": { "compartment": "compartment_70101", "id": "reaction_10551459", "reactome": "R-CEL-5339524", "name": "GLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70115" ], "products": [ "species_70113" ], "modifiers": [ [ "species_10525428", "catalyst" ], [ "species_113592", "inhibitor" ] ], "additional_components": [ "Q21381", "WBGene00043980", "Q9GYQ1", "WBGene00043980", "Q21382", "WBGene00043980", "Q9NEI8", "WBGene00043980", "Q21385", "WBGene00043980", "Q5WRR9", "WBGene00043980" ] }, "reaction_10570307": { "compartment": "compartment_70101", "id": "reaction_10570307", "reactome": "R-CEL-8981574", "name": "GLUT2 (SLC2A2) tetramer transports Glc from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70115" ], "products": [ "species_70113" ], "modifiers": [ [ "species_10512849", "catalyst" ] ], "additional_components": [ "Q23626", "WBGene00022014", "Q95QY6", "WBGene00022014", "Q9GPA2", "WBGene00022014", "Q9N309", "WBGene00022014", "Q9U2K5", "WBGene00022014", "Q9XU83", "WBGene00022014", "Q9XVL3", "WBGene00022014", "G5EC93", "WBGene00022014", "O16547", "WBGene00022014", "O44616", "WBGene00022014", "O44827", "WBGene00019207", "O45920", "WBGene00022014", "Q11114", "WBGene00022014", "Q19376", "WBGene00022014", "Q20734", "WBGene00022014", "Q23535", "WBGene00006865" ] }, "reaction_10570293": { "compartment": "compartment_70101", "id": "reaction_10570293", "reactome": "R-CEL-8981553", "name": "GLUT14 (SLC2A14) tetramer transports Glc from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70115" ], "products": [ "species_70113" ], "modifiers": [ [ "species_10570290", "catalyst" ] ], "additional_components": [ "Q21381", "WBGene00043980", "Q21382", "WBGene00043980", "Q21385", "WBGene00043980", "Q5WRR9", "WBGene00043980", "Q9GYQ1", "WBGene00043980", "Q9NEI8", "WBGene00043980" ] }, "reaction_10523383": { "compartment": "compartment_876", "id": "reaction_10523383", "reactome": "R-CEL-429036", "name": "SLC2A9 transports Fru, Glc, urate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_429078" ], "products": [ "species_429148" ], "modifiers": [ [ "species_10523380", "catalyst" ] ], "additional_components": [ "species_70113", "species_30034", "species_29532", "species_70113", "species_30034", "species_29532", "Q19376", "WBGene00022014", "Q20734", "WBGene00022014", "Q23535", "WBGene00006865", "Q23626", "WBGene00022014", "Q95QY6", "WBGene00022014", "Q9GPA2", "WBGene00022014", "Q9N309", "WBGene00022014", "Q9U2K5", "WBGene00022014", "Q9XU83", "WBGene00022014", "Q9XVL3", "WBGene00022014", "G5EC93", "WBGene00022014", "O16547", "WBGene00022014", "O44616", "WBGene00022014", "O44827", "WBGene00019207", "O45920", "WBGene00022014", "Q11114", "WBGene00022014" ] }, "reaction_10523335": { "compartment": "compartment_876", "id": "reaction_10523335", "reactome": "R-CEL-428779", "name": "GLUT7 and GLUT11 transport glucose and fructose", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428819" ], "products": [ "species_428802" ], "modifiers": [ [ "species_10523332", "catalyst" ] ], "additional_components": [ "species_70113", "species_29532", "species_70113", "species_29532", "G5EC93", "WBGene00022014", "O16547", "WBGene00022014", "O44616", "WBGene00022014", "O44827", "WBGene00019207", "O45920", "WBGene00022014", "Q11114", "WBGene00022014", "Q19376", "WBGene00022014", "Q20734", "WBGene00022014", "Q23535", "WBGene00006865", "Q23626", "WBGene00022014", "Q95QY6", "WBGene00022014", "Q9GPA2", "WBGene00022014", "Q9N309", "WBGene00022014", "Q9U2K5", "WBGene00022014", "Q9XU83", "WBGene00022014", "Q9XVL3", "WBGene00022014" ] }, "reaction_10525432": { "compartment": "compartment_70101", "id": "reaction_10525432", "reactome": "R-CEL-450088", "name": "GLUT1 tetramer binds 4xATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10525428" ], "products": [ "species_10525430" ], "modifiers": [], "additional_components": [ "Q21381", "WBGene00043980", "Q9GYQ1", "WBGene00043980", "Q21382", "WBGene00043980", "Q9NEI8", "WBGene00043980", "Q21385", "WBGene00043980", "Q5WRR9", "WBGene00043980", "Q21381", "WBGene00043980", "Q9GYQ1", "WBGene00043980", "Q21382", "WBGene00043980", "Q9NEI8", "WBGene00043980", "Q21385", "WBGene00043980", "Q5WRR9", "WBGene00043980", "species_29358" ] }, "reaction_10525434": { "compartment": "compartment_70101", "id": "reaction_10525434", "reactome": "R-CEL-450092", "name": "GLUT1:ATP tetramer dissociates to GLUT1 tetramer and 4xATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10525430" ], "products": [ "species_113592", "species_10525428" ], "modifiers": [], "additional_components": [ "Q21381", "WBGene00043980", "Q9GYQ1", "WBGene00043980", "Q21382", "WBGene00043980", "Q9NEI8", "WBGene00043980", "Q21385", "WBGene00043980", "Q5WRR9", "WBGene00043980", "species_29358", "Q21381", "WBGene00043980", "Q9GYQ1", "WBGene00043980", "Q21382", "WBGene00043980", "Q9NEI8", "WBGene00043980", "Q21385", "WBGene00043980", "Q5WRR9", "WBGene00043980" ] }, "reaction_10570298": { "compartment": "compartment_70101", "id": "reaction_10570298", "reactome": "R-CEL-8981564", "name": "GLUT3 (SLC2A3) tetramer transports Glc from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70115" ], "products": [ "species_70113" ], "modifiers": [ [ "species_10570295", "catalyst" ] ], "additional_components": [ "Q9NEI8", "WBGene00043980" ] }, "reaction_10525437": { "compartment": "compartment_70101", "id": "reaction_10525437", "reactome": "R-CEL-450095", "name": "GLUT2 (SLC2A2) transports Glc from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70113" ], "products": [ "species_70115" ], "modifiers": [ [ "species_10512849", "catalyst" ] ], "additional_components": [ "Q23626", "WBGene00022014", "Q95QY6", "WBGene00022014", "Q9GPA2", "WBGene00022014", "Q9N309", "WBGene00022014", "Q9U2K5", "WBGene00022014", "Q9XU83", "WBGene00022014", "Q9XVL3", "WBGene00022014", "G5EC93", "WBGene00022014", "O16547", "WBGene00022014", "O44616", "WBGene00022014", "O44827", "WBGene00019207", "O45920", "WBGene00022014", "Q11114", "WBGene00022014", "Q19376", "WBGene00022014", "Q20734", "WBGene00022014", "Q23535", "WBGene00006865" ] }, "reaction_10522496": { "compartment": "compartment_876", "id": "reaction_10522496", "reactome": "R-CEL-425678", "name": "SLC24A1-4 exchange extracellular 4Na+ for cytosolic Ca2+, K+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804", "species_74016", "species_74113" ], "products": [ "species_74126", "species_83910", "species_74112" ], "modifiers": [ [ "species_10522493", "catalyst" ] ], "additional_components": [ "G5EC02", "WBGene00003570", "P90858", "WBGene00003569" ] }, "reaction_10522504": { "compartment": "compartment_876", "id": "reaction_10522504", "reactome": "R-CEL-425822", "name": "K+-independent Li+/Ca2+ exchanger transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_425815", "species_74016" ], "products": [ "species_425810", "species_74112" ], "modifiers": [ [ "species_10522501", "catalyst" ] ], "additional_components": [ "WBGene00003572" ] }, "reaction_10522595": { "compartment": "compartment_876", "id": "reaction_10522595", "reactome": "R-CEL-425994", "name": "Na+/H+ exchanger transport (at cell membrane)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_74113" ], "products": [ "species_351626", "species_83910" ], "modifiers": [ [ "species_10522592", "catalyst" ] ], "additional_components": [ "Q8T5S1", "WBGene00003730", "G5EDU2", "WBGene00003732", "H2L039", "WBGene00003734", "O16452", "WBGene00003731", "P35449", "WBGene00003736" ] }, "reaction_10522518": { "compartment": "compartment_172574", "id": "reaction_10522518", "reactome": "R-CEL-425965", "name": "SLC9A9 exchanges Na+ for H+ across the late endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_425999", "species_83910" ], "products": [ "species_425977", "species_70106" ], "modifiers": [ [ "species_10522515", "catalyst" ] ], "additional_components": [ "WBGene00003733" ] }, "reaction_10522525": { "compartment": "compartment_171062", "id": "reaction_10522525", "reactome": "R-CEL-425983", "name": "SLC9A6,7 exchange Na+ for H+ across the early endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_425978", "species_83910" ], "products": [ "species_70106", "species_425971" ], "modifiers": [ [ "species_10522520", "catalyst" ] ], "additional_components": [ "WBGene00003733" ] }, "reaction_10522607": { "compartment": "compartment_20699", "id": "reaction_10522607", "reactome": "R-CEL-426015", "name": "Na+/H+ exchanger transport (at trans-golgi membrane)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_425969", "species_83910" ], "products": [ "species_70106", "species_425958" ], "modifiers": [ [ "species_10522604", "catalyst" ] ], "additional_components": [ "G5ED88", "WBGene00003733", "G5EBN7", "WBGene00003735" ] }, "reaction_10522643": { "compartment": "compartment_876", "id": "reaction_10522643", "reactome": "R-CEL-426130", "name": "SLC12A3 cotransports Cl-, Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_188972", "species_74113" ], "products": [ "species_83910", "species_352022" ], "modifiers": [ [ "species_10522640", "catalyst" ] ], "additional_components": [ "H8ESD5", "WBGene00012543", "P34261", "WBGene00015131" ] }, "reaction_10522634": { "compartment": "compartment_876", "id": "reaction_10522634", "reactome": "R-CEL-426086", "name": "SLC12A1,2 cotransports Na+, K+, 2Cl- from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74126", "species_188972", "species_74113" ], "products": [ "species_29804", "species_83910", "species_352022" ], "modifiers": [ [ "species_10522631", "catalyst" ] ], "additional_components": [ "P34261", "WBGene00015131", "H8ESD5", "WBGene00012543" ] }, "reaction_10522683": { "compartment": "compartment_876", "id": "reaction_10522683", "reactome": "R-CEL-426155", "name": "SLC12A4,5,6,7 cotransport K+, Cl- from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804", "species_352022" ], "products": [ "species_74126", "species_188972" ], "modifiers": [ [ "species_10522680", "catalyst" ] ], "additional_components": [ "S6FWN4", "WBGene00006504", "H2KZC3", "WBGene00019205", "Q09573", "WBGene00019289" ] }, "reaction_10523043": { "compartment": "compartment_201753", "id": "reaction_10523043", "reactome": "R-CEL-428052", "name": "SLC17A6,7,8 exchange cytosolic L-Glu for synaptic vesicle H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29404", "species_428548" ], "products": [ "species_70106", "species_428614" ], "modifiers": [ [ "species_10523040", "catalyst" ] ], "additional_components": [ "P34644", "WBGene00001135", "Q10046", "WBGene00011556", "G5EEK1", "WBGene00010755" ] }, "reaction_10523476": { "compartment": "compartment_876", "id": "reaction_10523476", "reactome": "R-CEL-429767", "name": "Passive I- efflux mediated by SMCT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_209785" ], "products": [ "species_209818" ], "modifiers": [ [ "species_10523470", "catalyst" ] ], "additional_components": [ "WBGene00018716" ] }, "reaction_10567367": { "compartment": "compartment_70101", "id": "reaction_10567367", "reactome": "R-CEL-8875623", "name": "SLC25A18,A22 cotransport Glu, H+ from cytosol to mitochondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29404", "species_70106" ], "products": [ "species_113529", "species_113552" ], "modifiers": [ [ "species_10567364", "catalyst" ] ], "additional_components": [ "Q20847", "WBGene00018901", "Q93540", "WBGene00008979" ] }, "reaction_10523415": { "compartment": "compartment_876", "id": "reaction_10523415", "reactome": "R-CEL-429591", "name": "SLC5A5 cotransports Na+ with I- from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_209818", "species_74113" ], "products": [ "species_209785", "species_83910" ], "modifiers": [ [ "species_10516451", "catalyst" ] ], "additional_components": [ "WBGene00018716" ] }, "reaction_10523020": { "compartment": "compartment_876", "id": "reaction_10523020", "reactome": "R-CEL-428015", "name": "SLC1A1,2,3,6,7 cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_428027", "species_29804", "species_74113" ], "products": [ "species_74126", "species_427997", "species_70106", "species_83910" ], "modifiers": [ [ "species_10516538", "catalyst" ] ], "additional_components": [ "species_427963", "species_6810061", "species_113552", "species_427963", "species_6810061", "species_113552", "Q21353", "WBGene00001621", "Q21751", "WBGene00001624", "Q22682", "WBGene00001622", "Q9UAY8", "WBGene00001625", "O18210", "WBGene00001623", "Q10901", "WBGene00001620" ] }, "reaction_10519220": { "compartment": "compartment_876", "id": "reaction_10519220", "reactome": "R-CEL-375405", "name": "SLC36A2 cotransports Gly, L-Pro with H+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_375409" ], "products": [ "species_70106", "species_375414" ], "modifiers": [ [ "species_10519217", "catalyst" ] ], "additional_components": [ "species_113538", "species_159549", "species_159549", "species_113538", "O62286", "WBGene00010421", "P34479", "WBGene00010307", "G4SQY7", "WBGene00020837", "Q18595", "WBGene00016628", "O45936", "WBGene00012804", "Q9XX44", "WBGene00012629" ] }, "reaction_10519225": { "compartment": "compartment_876", "id": "reaction_10519225", "reactome": "R-CEL-375417", "name": "SLC36A1-mediated uptake of glycine, proline, and alanine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_375400" ], "products": [ "species_70106", "species_375411" ], "modifiers": [ [ "species_10519222", "catalyst" ] ], "additional_components": [ "species_29432", "species_113538", "species_159549", "species_159549", "species_113538", "species_29432", "WBGene00012804" ] }, "reaction_10522933": { "compartment": "compartment_876", "id": "reaction_10522933", "reactome": "R-CEL-427605", "name": "SLC20A1,2 cotransport Pi, Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109277", "species_74113" ], "products": [ "species_29372", "species_83910" ], "modifiers": [ [ "species_10522930", "catalyst" ] ], "additional_components": [ "P91840", "WBGene00012285", "Q17454", "WBGene00015054", "O17404", "WBGene00017312", "Q17455", "WBGene00015055", "O45220", "WBGene00007141", "Q18697", "WBGene00016739" ] }, "reaction_10522941": { "compartment": "compartment_876", "id": "reaction_10522941", "reactome": "R-CEL-427645", "name": "SLC34A3 cotransports Pi, 2Na+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109277", "species_74113" ], "products": [ "species_29372", "species_83910" ], "modifiers": [ [ "species_10522938", "catalyst" ] ], "additional_components": [ "WBGene00022767" ] }, "reaction_10565621": { "compartment": "compartment_70101", "id": "reaction_10565621", "reactome": "R-CEL-8855062", "name": "SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2162252", "species_71284" ], "products": [ "species_2162265", "species_71285" ], "modifiers": [ [ "species_10565618", "catalyst" ] ], "additional_components": [ "WBGene00008364" ] }, "reaction_10566753": { "compartment": "compartment_876", "id": "reaction_10566753", "reactome": "R-CEL-8870354", "name": "SLC36A4 transports extracellular L-Pro to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352033" ], "products": [ "species_113538" ], "modifiers": [ [ "species_10566747", "catalyst" ] ], "additional_components": [ "O45936", "WBGene00012804", "O62286", "WBGene00010421", "P34479", "WBGene00010307", "Q18595", "WBGene00016628", "Q9XX44", "WBGene00012629", "G4SQY7", "WBGene00020837" ] }, "reaction_10519233": { "compartment": "compartment_876", "id": "reaction_10519233", "reactome": "R-CEL-375768", "name": "SLC7A2, isoform B (CAT-2B)-mediated uptake of cationic amino acids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_375765" ], "products": [ "species_375781" ], "modifiers": [ [ "species_10519230", "catalyst" ] ], "additional_components": [ "species_29444", "species_29468", "species_29468", "species_29444", "WBGene00013159" ] }, "reaction_10570181": { "compartment": "compartment_70101", "id": "reaction_10570181", "reactome": "R-CEL-8959781", "name": "SLC25A29 transports basic amino acids from cytosol to mitochondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8959777" ], "products": [ "species_8959775" ], "modifiers": [ [ "species_10570178", "catalyst" ] ], "additional_components": [ "CHEBI:28229", "species_29498", "species_29468", "species_29612", "species_29444", "CHEBI:27747", "species_29498", "species_29444", "species_29468", "species_29612", "CHEBI:28229", "CHEBI:27747", "WBGene00008320" ] }, "reaction_10519238": { "compartment": "compartment_876", "id": "reaction_10519238", "reactome": "R-CEL-375776", "name": "SLC7A1 (CAT-1)-mediated uptake of cationic amino acids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_375765" ], "products": [ "species_375781" ], "modifiers": [ [ "species_10519235", "catalyst" ] ], "additional_components": [ "species_29444", "species_29468", "species_29468", "species_29444", "WBGene00013159" ] }, "reaction_10519240": { "compartment": "compartment_876", "id": "reaction_10519240", "reactome": "R-CEL-375790", "name": "SLC7A2, isoform A (CAT-2A)-mediated uptake of cationic amino acids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_375765" ], "products": [ "species_375781" ], "modifiers": [ [ "species_10519230", "catalyst" ] ], "additional_components": [ "species_29444", "species_29468", "species_29468", "species_29444", "WBGene00013159" ] }, "reaction_10518156": { "compartment": "compartment_876", "id": "reaction_10518156", "reactome": "R-CEL-352379", "name": "SLC1A5-mediated exchange of alanine and glutamine across the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_83910", "species_352036", "species_29472", "species_74113" ], "products": [ "species_29432", "species_83910", "species_212615", "species_74113" ], "modifiers": [ [ "species_10518153", "catalyst" ] ], "additional_components": [ "Q21353", "WBGene00001621", "Q21751", "WBGene00001624", "Q22682", "WBGene00001622", "Q9UAY8", "WBGene00001625", "O18210", "WBGene00001623", "Q10901", "WBGene00001620" ] }, "reaction_10518133": { "compartment": "compartment_876", "id": "reaction_10518133", "reactome": "R-CEL-352347", "name": "SLC1A4-mediated exchange of extracellular serine for cytosolic alanine, threonine, or cysteine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352002", "species_83910", "species_352355", "species_74113" ], "products": [ "species_83910", "species_200736", "species_352359", "species_74113" ], "modifiers": [ [ "species_10518130", "catalyst" ] ], "additional_components": [ "species_200736", "species_351990", "species_29432", "species_111707", "species_29432", "species_351990", "species_111707", "species_200736", "Q9UAY8", "WBGene00001625", "O18210", "WBGene00001623", "Q10901", "WBGene00001620", "Q21353", "WBGene00001621", "Q21751", "WBGene00001624", "Q22682", "WBGene00001622" ] }, "reaction_10523018": { "compartment": "compartment_876", "id": "reaction_10523018", "reactome": "R-CEL-427998", "name": "Proton-coupled di- and tri-peptide cotransport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_428037" ], "products": [ "species_428026", "species_70106" ], "modifiers": [ [ "species_10523015", "catalyst" ] ], "additional_components": [ "CHEBI:90799", "CHEBI:47923", "CHEBI:47923", "CHEBI:90799", "WBGene00003876" ] }, "reaction_10523198": { "compartment": "compartment_201753", "id": "reaction_10523198", "reactome": "R-CEL-428625", "name": "Vesicular inhibitory amino acid transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428592", "species_428548" ], "products": [ "species_428632", "species_70106" ], "modifiers": [ [ "species_10523195", "catalyst" ] ], "additional_components": [ "species_159549", "species_352003", "species_352003", "species_159549", "WBGene00006783" ] }, "reaction_10565987": { "compartment": "compartment_876", "id": "reaction_10565987", "reactome": "R-CEL-8863494", "name": "ASICs bind STOML3, (STOM)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10565983", "species_10544954" ], "products": [ "species_10565985" ], "modifiers": [], "additional_components": [ "Q19958", "WBGene00006064", "Q20657", "WBGene00006065", "Q7YZV6", "WBGene00006067", "G3MU02", "WBGene00007775", "G5EGI5", "WBGene00001465", "species_70106", "G3MU02", "WBGene00007775", "G5EGI5", "WBGene00001465", "species_70106", "Q19958", "WBGene00006064", "Q20657", "WBGene00006065", "Q7YZV6", "WBGene00006067" ] }, "reaction_10544963": { "compartment": "compartment_70101", "id": "reaction_10544963", "reactome": "R-CEL-2671885", "name": "ASIC trimers:H+ transport extracellular Na+ to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74113" ], "products": [ "species_83910" ], "modifiers": [ [ "species_10544954", "catalyst" ], [ "species_2672379", "inhibitor" ], [ "species_2672383", "inhibitor" ], [ "species_10544961", "inhibitor" ] ], "additional_components": [ "G3MU02", "WBGene00007775", "G5EGI5", "WBGene00001465", "species_70106", "G3MU02", "WBGene00007775", "G5EGI5", "WBGene00001465" ] }, "reaction_10545603": { "compartment": "compartment_70101", "id": "reaction_10545603", "reactome": "R-CEL-2744242", "name": "TTYH2/3 transport cytosolic Cl- to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352022" ], "products": [ "species_188972" ], "modifiers": [ [ "species_10545598", "catalyst" ], [ "species_74016", "catalyst" ] ], "additional_components": [ "WBGene00009632" ] }, "reaction_10545477": { "compartment": "compartment_70101", "id": "reaction_10545477", "reactome": "R-CEL-2730692", "name": "CLCN4/5/6 exchange Cl- for H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_2731008" ], "products": [ "species_74722", "species_352022" ], "modifiers": [ [ "species_10545472", "catalyst" ] ], "additional_components": [ "WBGene00000532" ] }, "reaction_10545608": { "compartment": "compartment_70101", "id": "reaction_10545608", "reactome": "R-CEL-2744349", "name": "TTYH1 transports cytosolic Cl- to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352022" ], "products": [ "species_188972" ], "modifiers": [ [ "species_10545605", "catalyst" ] ], "additional_components": [ "WBGene00009632" ] }, "reaction_10573259": { "compartment": "compartment_70101", "id": "reaction_10573259", "reactome": "R-CEL-9701141", "name": "TRPV1 transports Ca2+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74112" ], "products": [ "species_74016" ], "modifiers": [ [ "species_10547087", "catalyst" ] ], "additional_components": [ "WBGene00003889" ] }, "reaction_10547102": { "compartment": "compartment_70101", "id": "reaction_10547102", "reactome": "R-CEL-3295579", "name": "TRPs transport extracellular Ca2+ to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74112" ], "products": [ "species_74016" ], "modifiers": [ [ "species_10547099", "catalyst" ] ], "additional_components": [ "G5ECM4", "WBGene00001795", "P34641", "WBGene00000425", "Q20766", "WBGene00001796", "Q93971", "WBGene00001651", "Q8T666", "WBGene00000846", "Q8I6Y9", "WBGene00006615", "Q19377", "WBGene00008731", "Q23141", "WBGene00020972", "G5EE29", "WBGene00021404", "P91448", "WBGene00004149", "G5EBV8", "WBGene00003889" ] }, "reaction_10547119": { "compartment": "compartment_70101", "id": "reaction_10547119", "reactome": "R-CEL-3295580", "name": "TRPM4,5 transport extracellular Na+ to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74113" ], "products": [ "species_83910" ], "modifiers": [ [ "species_10547116", "catalyst" ] ], "additional_components": [ "Q19377", "WBGene00008731", "G5EE29", "WBGene00021404", "P91448", "WBGene00004149", "Q23141", "WBGene00020972" ] }, "reaction_10572715": { "compartment": "compartment_876", "id": "reaction_10572715", "reactome": "R-CEL-9650165", "name": "ASIC trimers bind H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_10572713" ], "products": [ "species_10544954" ], "modifiers": [], "additional_components": [ "G3MU02", "WBGene00007775", "G5EGI5", "WBGene00001465", "G3MU02", "WBGene00007775", "G5EGI5", "WBGene00001465", "species_70106" ] }, "reaction_10545454": { "compartment": "compartment_70101", "id": "reaction_10545454", "reactome": "R-CEL-2682349", "name": "RAF1:SGK:TSC22D3:WPP ubiquitinates SCNN channels", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10545262", "species_113592", "species_10502375" ], "products": [ "species_29370", "species_947590", "species_10545415" ], "modifiers": [ [ "species_10545440", "catalyst" ], [ "species_10545446", "catalyst" ] ], "additional_components": [ "P24612", "WBGene00003168", "Q21974", "WBGene00006748", "P34886", "WBGene00003174", "Q22851", "WBGene00012137", "P91100", "WBGene00016066", "Q22970", "WBGene00017879", "P91102", "WBGene00016064", "Q8MPW0", "WBGene00011891", "P91103", "WBGene00016063", "Q93205", "WBGene00007518", "P91835", "WBGene00012116", "Q9U1T8", "WBGene00013487", "Q09274", "WBGene00006832", "Q9U1T9", "WBGene00013486", "Q10025", "WBGene00020897", "Q9XTS9", "WBGene00013480", "G5EFH3", "WBGene00010334", "Q18077", "WBGene00015957", "O01635", "WBGene00022815", "Q18651", "WBGene00016699", "O01664", "WBGene00020903", "Q19038", "WBGene00000952", "O45402", "WBGene00009073", "Q19777", "WBGene00009109", "P24585", "WBGene00000950", "Q20852", "WBGene00018906", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "P91103", "WBGene00016063", "P91835", "WBGene00012116", "Q09274", "WBGene00006832", "Q10025", "WBGene00020897", "Q18077", "WBGene00015957", "Q18651", "WBGene00016699", "Q19038", "WBGene00000952", "Q19777", "WBGene00009109", "Q20852", "WBGene00018906", "Q21974", "WBGene00006748", "Q22851", "WBGene00012137", "Q22970", "WBGene00017879", "Q8MPW0", "WBGene00011891", "Q93205", "WBGene00007518", "Q9U1T8", "WBGene00013487", "Q9U1T9", "WBGene00013486", "Q9XTS9", "WBGene00013480", "G5EFH3", "WBGene00010334", "O01635", "WBGene00022815", "O01664", "WBGene00020903", "O45402", "WBGene00009073", "P24585", "WBGene00000950", "P24612", "WBGene00003168", "P34886", "WBGene00003174", "P91100", "WBGene00016066", "P91102", "WBGene00016064", "A0A061ACQ8", "WBGene00022358", "Q9N2Z7", "WBGene00007009", "Q2PJ68", "WBGene00004789", "H2KYK3", "WBGene00016269", "Q9U290", "WBGene00016269", "Q07292", "WBGene00003030", "WBGene00006941" ] }, "reaction_10545550": { "compartment": "compartment_70101", "id": "reaction_10545550", "reactome": "R-CEL-2730959", "name": "CLCN7:OSTM1 exchanges Cl- for H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2730999", "species_70106" ], "products": [ "species_428040", "species_352022" ], "modifiers": [ [ "species_10545547", "catalyst" ] ], "additional_components": [ "G5EC75", "WBGene00000533", "Q09322", "WBGene00009627" ] }, "reaction_10545265": { "compartment": "compartment_984", "id": "reaction_10545265", "reactome": "R-CEL-2672334", "name": "SCNN channels transport extracellular Na+ to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74113" ], "products": [ "species_83910" ], "modifiers": [ [ "species_10545262", "catalyst" ], [ "species_2672379", "inhibitor" ] ], "additional_components": [ "P24612", "WBGene00003168", "Q21974", "WBGene00006748", "P34886", "WBGene00003174", "Q22851", "WBGene00012137", "P91100", "WBGene00016066", "Q22970", "WBGene00017879", "P91102", "WBGene00016064", "Q8MPW0", "WBGene00011891", "P91103", "WBGene00016063", "Q93205", "WBGene00007518", "P91835", "WBGene00012116", "Q9U1T8", "WBGene00013487", "Q09274", "WBGene00006832", "Q9U1T9", "WBGene00013486", "Q10025", "WBGene00020897", "Q9XTS9", "WBGene00013480", "G5EFH3", "WBGene00010334", "Q18077", "WBGene00015957", "O01635", "WBGene00022815", "Q18651", "WBGene00016699", "O01664", "WBGene00020903", "Q19038", "WBGene00000952", "O45402", "WBGene00009073", "Q19777", "WBGene00009109", "P24585", "WBGene00000950", "Q20852", "WBGene00018906" ] }, "reaction_10545970": { "compartment": "compartment_984", "id": "reaction_10545970", "reactome": "R-CEL-2872444", "name": "SLC9B1/C2 exchange Na+ for H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_74113" ], "products": [ "species_351626", "species_83910" ], "modifiers": [ [ "species_10545967", "catalyst" ] ], "additional_components": [ "G5EFS0", "WBGene00009618", "Q20273", "WBGene00009617", "Q9XU88", "WBGene00010214" ] }, "reaction_10545907": { "compartment": "compartment_70101", "id": "reaction_10545907", "reactome": "R-CEL-2744361", "name": "BESTs transport cytosolic Cl- to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352022" ], "products": [ "species_188972" ], "modifiers": [ [ "species_10545904", "catalyst" ], [ "species_74016", "catalyst" ] ], "additional_components": [ "O17206", "WBGene00015286", "Q18303", "WBGene00007808", "O17671", "WBGene00008186", "Q19978", "WBGene00009340", "O18303", "WBGene00014102", "Q21973", "WBGene00011258", "O18304", "WBGene00014103", "Q22566", "WBGene00020559", "O45363", "WBGene00008821", "Q23369", "WBGene00013921", "O45435", "WBGene00009323", "Q7YXH3", "WBGene00020046", "O62095", "WBGene00007988", "Q94175", "WBGene00016613", "P34319", "WBGene00007404", "Q965X4", "WBGene00021368", "P34577", "WBGene00011868", "Q9NA59", "WBGene00013520", "A5JYR2", "WBGene00014989", "P34672", "WBGene00022797", "J7RNL4", "WBGene00220250", "Q17528", "WBGene00007203", "O16779", "WBGene00206487", "Q17529", "WBGene00007204", "O17205", "WBGene00015288", "Q17851", "WBGene00015628" ] }, "reaction_10545975": { "compartment": "compartment_17927", "id": "reaction_10545975", "reactome": "R-CEL-2889070", "name": "SLC9B2 exchanges Na+, Li+ for H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113529", "species_2889081" ], "products": [ "species_2889062", "species_163953" ], "modifiers": [ [ "species_10545972", "catalyst" ] ], "additional_components": [ "species_83910", "species_425810", "species_425810", "species_83910", "WBGene00009617" ] }, "reaction_10545593": { "compartment": "compartment_70101", "id": "reaction_10545593", "reactome": "R-CEL-2744228", "name": "CLCN1/2/KA/KB transport cytosolic Cl- to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352022" ], "products": [ "species_188972" ], "modifiers": [ [ "species_10545590", "catalyst" ] ], "additional_components": [ "Q9BMK9", "WBGene00000530", "G5EG93", "WBGene00000529", "H2L0J1", "WBGene00000531", "Q22833", "WBGene00000528" ] }, "reaction_10545467": { "compartment": "compartment_70101", "id": "reaction_10545467", "reactome": "R-CEL-2684901", "name": "ANOs transport cytosolic Cl- to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352022" ], "products": [ "species_188972" ], "modifiers": [ [ "species_10545464", "catalyst" ], [ "species_74016", "catalyst" ] ], "additional_components": [ "WBGene00013326" ] }, "reaction_10545916": { "compartment": "compartment_70101", "id": "reaction_10545916", "reactome": "R-CEL-2752067", "name": "BESTs transport cytosolic HCO3- to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111627" ], "products": [ "species_425425" ], "modifiers": [ [ "species_10545904", "catalyst" ] ], "additional_components": [ "O17206", "WBGene00015286", "Q18303", "WBGene00007808", "O17671", "WBGene00008186", "Q19978", "WBGene00009340", "O18303", "WBGene00014102", "Q21973", "WBGene00011258", "O18304", "WBGene00014103", "Q22566", "WBGene00020559", "O45363", "WBGene00008821", "Q23369", "WBGene00013921", "O45435", "WBGene00009323", "Q7YXH3", "WBGene00020046", "O62095", "WBGene00007988", "Q94175", "WBGene00016613", "P34319", "WBGene00007404", "Q965X4", "WBGene00021368", "P34577", "WBGene00011868", "Q9NA59", "WBGene00013520", "A5JYR2", "WBGene00014989", "P34672", "WBGene00022797", "J7RNL4", "WBGene00220250", "Q17528", "WBGene00007203", "O16779", "WBGene00206487", "Q17529", "WBGene00007204", "O17205", "WBGene00015288", "Q17851", "WBGene00015628" ] }, "reaction_10529392": { "compartment": "compartment_20699", "id": "reaction_10529392", "reactome": "R-CEL-936883", "name": "ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_74016" ], "products": [ "species_29372", "species_29370", "species_167012" ], "modifiers": [ [ "species_10529389", "catalyst" ] ], "additional_components": [ "species_114632", "G5EDU1", "WBGene00004063" ] }, "reaction_10523009": { "compartment": "compartment_12045", "id": "reaction_10523009", "reactome": "R-CEL-427910", "name": "ATP2A1-3 transport Ca2+ from cytosol to ER lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_156540", "species_74016" ], "products": [ "species_70106", "species_111875" ], "modifiers": [ [ "species_10522985", "catalyst" ], [ "species_10523007", "catalyst" ] ], "additional_components": [ "WBGene00004736", "species_74016", "Q11083", "WBGene00020378", "P04630", "WBGene00000285", "G5EF37", "WBGene00003934", "A0A2C9C3L3", "WBGene00020378", "Q18136", "WBGene00006861", "Q09665", "WBGene00006583", "O02159", "WBGene00020378", "G5EDZ8", "WBGene00000288", "Q94288", "WBGene00000287", "Q09980", "WBGene00017394", "O16305", "WBGene00000552", "G5EEG0", "WBGene00000286", "O62305", "WBGene00006779" ] }, "reaction_10529571": { "compartment": "compartment_70101", "id": "reaction_10529571", "reactome": "R-CEL-947591", "name": "P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_947588", "species_113592" ], "products": [ "species_29372", "species_29370", "species_947594" ], "modifiers": [ [ "species_10529510", "catalyst" ] ], "additional_components": [ "species_33625", "species_8959490", "species_8959490", "species_33625", "O18182", "WBGene00012360", "Q7JPE3", "WBGene00020784", "Q9U280", "WBGene00013034", "U4PBV8", "WBGene00019166" ] }, "reaction_10556898": { "compartment": "compartment_70101", "id": "reaction_10556898", "reactome": "R-CEL-5692462", "name": "ATP13A1 transports Mn2+ from cytosol to ER lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_29418", "species_113592" ], "products": [ "species_29372", "species_29370", "species_1981162" ], "modifiers": [ [ "species_10556895", "catalyst" ] ], "additional_components": [ "WBGene00007514" ] }, "reaction_10556918": { "compartment": "compartment_70101", "id": "reaction_10556918", "reactome": "R-CEL-5692480", "name": "ATP13A2 transports cations from cytosol to lysosomal lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_5692450" ], "products": [ "species_29372", "species_29370", "species_5692484" ], "modifiers": [ [ "species_10556915", "catalyst" ] ], "additional_components": [ "Q9N323", "WBGene00022010", "Q21286", "WBGene00019493", "Q27533", "WBGene00012341" ] }, "reaction_10529455": { "compartment": "compartment_876", "id": "reaction_10529455", "reactome": "R-CEL-937311", "name": "ATP4A/12A:ATP4B exchanges K+ for H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74126", "species_29356", "species_70106", "species_113592" ], "products": [ "species_351626", "species_29804", "species_29372", "species_29370" ], "modifiers": [ [ "species_10529452", "catalyst" ] ], "additional_components": [ "O16331", "WBGene00015660", "O16436", "WBGene00015338", "P90735", "WBGene00001137", "G5EBE7", "WBGene00013672", "G5EFV6", "WBGene00007248", "Q9XUG9", "WBGene00008074", "Q9XUY5", "WBGene00010117", "Q93235", "WBGene00007646" ] }, "reaction_10565635": { "compartment": "compartment_876", "id": "reaction_10565635", "reactome": "R-CEL-8855130", "name": "VLDLR:PCSK9:Clathrin-coated vesicle translocates from the plasma membrane to lysosomal membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10565625" ], "products": [ "species_10565633" ], "modifiers": [], "additional_components": [ "P34574", "WBGene00011867", "P90961", "WBGene00020246", "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q04833", "WBGene00003071", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "Q9N4F3", "WBGene00000160", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q22601", "WBGene00000161", "Q04833", "WBGene00003071" ] }, "reaction_10567491": { "compartment": "compartment_161320", "id": "reaction_10567491", "reactome": "R-CEL-8876472", "name": "NPC2 binds CHOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10567487", "species_8848047" ], "products": [ "species_10567489" ], "modifiers": [], "additional_components": [ "WBGene00006452", "species_193384", "O17271", "WBGene00006452" ] }, "reaction_10511510": { "compartment": "compartment_74700", "id": "reaction_10511510", "reactome": "R-CEL-171087", "name": "LDLR [endosome membrane] => LDLR [plasma membrane]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10511502" ], "products": [ "species_10511508" ], "modifiers": [], "additional_components": [ "O01768", "WBGene00003072", "Q04833", "WBGene00003071", "O01768", "WBGene00003072", "Q04833", "WBGene00003071" ] }, "reaction_10567497": { "compartment": "compartment_161320", "id": "reaction_10567497", "reactome": "R-CEL-8876484", "name": "NPC2 transfers CHOL to NPC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10567493", "species_10567489" ], "products": [ "species_10567487", "species_10567495" ], "modifiers": [], "additional_components": [ "WBGene00003562", "species_193384", "O17271", "WBGene00006452", "WBGene00006452", "P34389", "WBGene00003562", "species_193384" ] }, "reaction_10567499": { "compartment": "compartment_12045", "id": "reaction_10567499", "reactome": "R-CEL-8876485", "name": "CHOL translocates from lysosome membrane to ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10567495" ], "products": [ "species_193384", "species_10567493" ], "modifiers": [], "additional_components": [ "P34389", "WBGene00003562", "species_193384", "WBGene00003562" ] }, "reaction_10558091": { "compartment": "compartment_1660541", "id": "reaction_10558091", "reactome": "R-CEL-6784729", "name": "PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10558057" ], "products": [ "species_10558089" ], "modifiers": [], "additional_components": [ "P34574", "WBGene00011867", "P90961", "WBGene00020246", "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "O01768", "WBGene00003072", "Q04833", "WBGene00003071", "O01768", "WBGene00003072", "Q04833", "WBGene00003071", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "Q9N4F3", "WBGene00000160", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q22601", "WBGene00000161" ] }, "reaction_10567546": { "compartment": "compartment_12045", "id": "reaction_10567546", "reactome": "R-CEL-8876696", "name": "SOAT1,2 transfer acyl group to CHOL forming CHEST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193384", "species_1500578" ], "products": [ "species_8876704", "species_76194" ], "modifiers": [ [ "species_10567541", "catalyst" ] ], "additional_components": [ "WBGene00007174" ] }, "reaction_10558093": { "compartment": "compartment_1660541", "id": "reaction_10558093", "reactome": "R-CEL-6784738", "name": "Degradation of PCSK9:LDLR:Clathrin-coated vesicle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10558089" ], "products": [ "species_10558087" ], "modifiers": [], "additional_components": [ "O01768", "WBGene00003072", "Q04833", "WBGene00003071", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "Q9N4F3", "WBGene00000160", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q22601", "WBGene00000161", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "Q9N4F3", "WBGene00000160", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q22601", "WBGene00000161" ] }, "reaction_10564126": { "compartment": "compartment_70101", "id": "reaction_10564126", "reactome": "R-CEL-6813720", "name": "NCEH1 hydrolyzes cholesterol esters", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_163579" ], "products": [ "species_8876730", "species_216762" ], "modifiers": [ [ "species_10564123", "catalyst" ] ], "additional_components": [ "Q19839", "WBGene00009186", "Q7JMM5", "WBGene00017515", "Q94187", "WBGene00017515", "Q9XWL5", "WBGene00012810" ] }, "reaction_10511233": { "compartment": "compartment_70101", "id": "reaction_10511233", "reactome": "R-CEL-170126", "name": "Phosphorylation of Cyclin B1 in the CRS domain", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10511226", "species_113592" ], "products": [ "species_29370", "species_10511126" ], "modifiers": [ [ "species_10511230", "catalyst" ] ], "additional_components": [ "Q10653", "WBGene00000865", "Q9BLB5", "WBGene00000867", "O45926", "WBGene00000866", "P34556", "WBGene00000405", "Q9BLB5", "WBGene00000867", "O45926", "WBGene00000866", "Q10653", "WBGene00000865", "P34556", "WBGene00000405" ] }, "reaction_10565795": { "compartment": "compartment_7660", "id": "reaction_10565795", "reactome": "R-CEL-8856945", "name": "PP2A methylation by LCMT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10533066" ], "products": [ "species_77502", "species_10565787" ], "modifiers": [ [ "species_10565792", "catalyst" ] ], "additional_components": [ "WBGene00007137" ] }, "reaction_10511235": { "compartment": "compartment_13231", "id": "reaction_10511235", "reactome": "R-CEL-170131", "name": "Translocation of CRS phosphorylated Cyclin B1:Cdc2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10511126" ], "products": [ "species_10511156" ], "modifiers": [], "additional_components": [ "Q9BLB5", "WBGene00000867", "O45926", "WBGene00000866", "Q10653", "WBGene00000865", "P34556", "WBGene00000405", "O45926", "WBGene00000866", "Q10653", "WBGene00000865", "Q9BLB5", "WBGene00000867", "P34556", "WBGene00000405" ] }, "reaction_10511269": { "compartment": "compartment_70101", "id": "reaction_10511269", "reactome": "R-CEL-170161", "name": "Dephosphorylation of cytoplasmic Cyclin B1/B2:phospho-Cdc2 (Thr 14, Tyr 15) complexes by CDC25B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10511262", "species_29356" ], "products": [ "species_29372", "species_10511266" ], "modifiers": [ [ "species_10511222", "catalyst" ] ], "additional_components": [ "Q10653", "WBGene00000865", "Q9BLB5", "WBGene00000867", "O45926", "WBGene00000866", "P34556", "WBGene00000405", "Q10653", "WBGene00000865", "P34556", "WBGene00000405", "Q9BLB5", "WBGene00000867", "O45926", "WBGene00000866", "WBGene00000389" ] }, "reaction_10511239": { "compartment": "compartment_13231", "id": "reaction_10511239", "reactome": "R-CEL-170149", "name": "Translocation of active Cdc25C to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509859" ], "products": [ "species_10511237" ], "modifiers": [], "additional_components": [ "WBGene00000389", "WBGene00000389" ] }, "reaction_10511175": { "compartment": "compartment_70101", "id": "reaction_10511175", "reactome": "R-CEL-170055", "name": "Myt-1 mediated phosphorylation of Cyclin B:Cdc2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10511168" ], "products": [ "species_29370", "species_10511170" ], "modifiers": [ [ "species_10511172", "catalyst" ] ], "additional_components": [ "Q10653", "WBGene00000865", "Q9BLB5", "WBGene00000867", "O45926", "WBGene00000866", "P34556", "WBGene00000405", "P34556", "WBGene00000405", "Q10653", "WBGene00000865", "Q9BLB5", "WBGene00000867", "O45926", "WBGene00000866", "WBGene00006940" ] }, "reaction_10511208": { "compartment": "compartment_70101", "id": "reaction_10511208", "reactome": "R-CEL-170084", "name": "Formation of Cyclin A:Cdc2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10511166", "species_10511204" ], "products": [ "species_10511206" ], "modifiers": [], "additional_components": [ "WBGene00000405", "P34556", "WBGene00000405" ] }, "reaction_10511177": { "compartment": "compartment_70101", "id": "reaction_10511177", "reactome": "R-CEL-170057", "name": "Formation of Cyclin B:Cdc2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10511166", "species_10511164" ], "products": [ "species_10511168" ], "modifiers": [], "additional_components": [ "WBGene00000405", "Q10653", "WBGene00000865", "Q9BLB5", "WBGene00000867", "O45926", "WBGene00000866", "Q10653", "WBGene00000865", "Q9BLB5", "WBGene00000867", "O45926", "WBGene00000866", "P34556", "WBGene00000405" ] }, "reaction_10565803": { "compartment": "compartment_7660", "id": "reaction_10565803", "reactome": "R-CEL-8856951", "name": "PP2A demethylation by PPME1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10565787" ], "products": [ "species_10533066", "species_8857797" ], "modifiers": [ [ "species_10565800", "catalyst" ] ], "additional_components": [ "WBGene00007188" ] }, "reaction_10511214": { "compartment": "compartment_7660", "id": "reaction_10511214", "reactome": "R-CEL-170087", "name": "CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10511210" ], "products": [ "species_113582", "species_10511212" ], "modifiers": [ [ "species_10506279", "catalyst" ] ], "additional_components": [ "P34556", "WBGene00000405", "P34556", "WBGene00000405", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408" ] }, "reaction_10511246": { "compartment": "compartment_7660", "id": "reaction_10511246", "reactome": "R-CEL-170153", "name": "Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10511144" ], "products": [ "species_113550", "species_10511241" ], "modifiers": [ [ "species_10511243", "catalyst" ] ], "additional_components": [ "O45926", "WBGene00000866", "Q10653", "WBGene00000865", "Q9BLB5", "WBGene00000867", "P34556", "WBGene00000405", "O45926", "WBGene00000866", "Q10653", "WBGene00000865", "Q9BLB5", "WBGene00000867", "P34556", "WBGene00000405", "Q21762", "WBGene00000389" ] }, "reaction_10511218": { "compartment": "compartment_13231", "id": "reaction_10511218", "reactome": "R-CEL-170088", "name": "Translocation of Cyclin A:phospho-Cdc2 (Thr 14) to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10511216" ], "products": [ "species_10511210" ], "modifiers": [], "additional_components": [ "P34556", "WBGene00000405", "P34556", "WBGene00000405" ] }, "reaction_10511252": { "compartment": "compartment_7660", "id": "reaction_10511252", "reactome": "R-CEL-170158", "name": "Dephosphorylation of nuclear Cyclin A:phospho-Cdc2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10511248" ], "products": [ "species_113550", "species_10511250" ], "modifiers": [ [ "species_10502759", "catalyst" ] ], "additional_components": [ "P34556", "WBGene00000405", "P34556", "WBGene00000405", "WBGene00000389" ] }, "reaction_10511188": { "compartment": "compartment_13231", "id": "reaction_10511188", "reactome": "R-CEL-170072", "name": "Translocation of Cyclin B1:phospho-Cdc2 to the cytoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10511144" ], "products": [ "species_10511104" ], "modifiers": [ [ "species_10511186", "catalyst" ] ], "additional_components": [ "O45926", "WBGene00000866", "Q10653", "WBGene00000865", "Q9BLB5", "WBGene00000867", "P34556", "WBGene00000405", "Q10653", "WBGene00000865", "Q9BLB5", "WBGene00000867", "O45926", "WBGene00000866", "P34556", "WBGene00000405", "WBGene00002078" ] }, "reaction_10511160": { "compartment": "compartment_13231", "id": "reaction_10511160", "reactome": "R-CEL-170044", "name": "Translocation of Cyclin B1:phospho-Cdc2 complexes to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10511128" ], "products": [ "species_10511158" ], "modifiers": [], "additional_components": [ "Q10653", "WBGene00000865", "Q9BLB5", "WBGene00000867", "O45926", "WBGene00000866", "P34556", "WBGene00000405", "O45926", "WBGene00000866", "Q10653", "WBGene00000865", "Q9BLB5", "WBGene00000867", "P34556", "WBGene00000405" ] }, "reaction_10511192": { "compartment": "compartment_7660", "id": "reaction_10511192", "reactome": "R-CEL-170076", "name": "CAK-mediated phosphorylation of Cyclin B1:Cdc2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10511140" ], "products": [ "species_113582", "species_10511181" ], "modifiers": [ [ "species_10506279", "catalyst" ] ], "additional_components": [ "O45926", "WBGene00000866", "Q10653", "WBGene00000865", "Q9BLB5", "WBGene00000867", "P34556", "WBGene00000405", "O45926", "WBGene00000866", "Q10653", "WBGene00000865", "Q9BLB5", "WBGene00000867", "P34556", "WBGene00000405", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408" ] }, "reaction_10511224": { "compartment": "compartment_13231", "id": "reaction_10511224", "reactome": "R-CEL-170120", "name": "Translocation of Cdc25B to the cytoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10511220" ], "products": [ "species_10511222" ], "modifiers": [], "additional_components": [ "WBGene00000389", "WBGene00000389" ] }, "reaction_10511258": { "compartment": "compartment_13231", "id": "reaction_10511258", "reactome": "R-CEL-170159", "name": "Translocation of Cdc25 to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10511256" ], "products": [ "species_10511243" ], "modifiers": [], "additional_components": [ "Q21762", "WBGene00000389", "Q21762", "WBGene00000389" ] }, "reaction_10546257": { "compartment": "compartment_70101", "id": "reaction_10546257", "reactome": "R-CEL-3002798", "name": "Cytosolic PLK1 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509861" ], "products": [ "species_10509851" ], "modifiers": [], "additional_components": [ "WBGene00004043", "WBGene00004043" ] }, "reaction_10546277": { "compartment": "compartment_7660", "id": "reaction_10546277", "reactome": "R-CEL-3002811", "name": "Myosin phosphatase dephosphorylates PLK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10509851" ], "products": [ "species_113550", "species_10546259" ], "modifiers": [ [ "species_10546274", "catalyst" ] ], "additional_components": [ "WBGene00004043", "WBGene00004043", "Q27497", "WBGene00001747", "G5ECD7", "WBGene00003196" ] }, "reaction_10548983": { "compartment": "compartment_70101", "id": "reaction_10548983", "reactome": "R-CEL-4086410", "name": "CDK1 phosphorylates BORA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10548981" ], "products": [ "species_29370", "species_10546195" ], "modifiers": [ [ "species_10511266", "catalyst" ] ], "additional_components": [ "WBGene00010198", "WBGene00010198", "Q10653", "WBGene00000865", "P34556", "WBGene00000405", "Q9BLB5", "WBGene00000867", "O45926", "WBGene00000866" ] }, "reaction_10546204": { "compartment": "compartment_70101", "id": "reaction_10546204", "reactome": "R-CEL-3000327", "name": "PLK1 phosphorylates BORA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10546197" ], "products": [ "species_29370", "species_10546201", "species_10509861" ], "modifiers": [ [ "species_10546197", "catalyst" ] ], "additional_components": [ "H2FLK2", "WBGene00010198", "Q9N2L7", "WBGene00004043", "WBGene00010198", "WBGene00004043", "H2FLK2", "WBGene00010198", "Q9N2L7", "WBGene00004043" ] }, "reaction_10565466": { "compartment": "compartment_70101", "id": "reaction_10565466", "reactome": "R-CEL-8854041", "name": "SCF-FBXL7 ubiquitinates AURKA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10565421", "species_10502375" ], "products": [ "species_10565463" ], "modifiers": [ [ "species_10565421", "catalyst" ] ], "additional_components": [ "G5ECU1", "WBGene00004807", "Q17389", "WBGene00000836", "Q23457", "WBGene00004320", "O01427", "WBGene00000099", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "O01427", "WBGene00000099", "G5ECU1", "WBGene00004807", "Q17389", "WBGene00000836", "Q23457", "WBGene00004320", "G5ECU1", "WBGene00004807", "Q17389", "WBGene00000836", "Q23457", "WBGene00004320", "O01427", "WBGene00000099" ] }, "reaction_10565468": { "compartment": "compartment_70101", "id": "reaction_10565468", "reactome": "R-CEL-8854044", "name": "Proteasome degrades AURKA ubiquitinated by SCF-FBXL7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10565463" ], "products": [ "species_10502375", "species_10565414" ], "modifiers": [ [ "species_10502572", "catalyst" ] ], "additional_components": [ "O01427", "WBGene00000099", "G5ECU1", "WBGene00004807", "Q17389", "WBGene00000836", "Q23457", "WBGene00004320", "P49632", "WBGene00006728", "P37165", "WBGene00006725", "P0CG71", "WBGene00006727", "G5ECU1", "WBGene00004807", "Q17389", "WBGene00000836", "Q23457", "WBGene00004320", "P91477", "WBGene00003950", "Q95PZ7", "WBGene00013435", "Q18115", "WBGene00004459", "O62102", "WBGene00003948", "O17071", "WBGene00004504", "Q10920", "WBGene00016623", "P34286", "WBGene00003952", "Q9XTT9", "WBGene00004506", "Q23449", "WBGene00004468", "Q95005", "WBGene00003925", "P46502", "WBGene00004503", "O61792", "WBGene00004464", "O17586", "WBGene00003922", "O76371", "WBGene00004505", "Q20585", "WBGene00004463", "Q95008", "WBGene00003926", "Q18787", "WBGene00004501", "Q20058", "WBGene00009445", "Q9N599", "WBGene00003924", "O16368", "WBGene00004502", "O61742", "WBGene00004466", "Q09583", "WBGene00003928", "Q966I8", "WBGene00003947", "Q04908", "WBGene00004460", "Q9XUV0", "WBGene00003951", "Q27488", "WBGene00003923", "Q9GZH5", "WBGene00004458", "O44156", "WBGene00003927", "Q22253", "WBGene00004465", "O76577", "WBGene00004467", "P90868", "WBGene00003953", "Q19324", "WBGene00004461", "Q17971", "WBGene00007588", "Q23237", "WBGene00003949", "Q20938", "WBGene00004462" ] }, "reaction_10565423": { "compartment": "compartment_70101", "id": "reaction_10565423", "reactome": "R-CEL-8853496", "name": "SCF:FBXL7 binds AURKA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10565419", "species_10565414" ], "products": [ "species_10565421" ], "modifiers": [], "additional_components": [ "WBGene00000099", "G5ECU1", "WBGene00004807", "Q17389", "WBGene00000836", "Q23457", "WBGene00004320", "G5ECU1", "WBGene00004807", "Q17389", "WBGene00000836", "Q23457", "WBGene00004320", "O01427", "WBGene00000099" ] }, "reaction_10565570": { "compartment": "compartment_20699", "id": "reaction_10565570", "reactome": "R-CEL-8854303", "name": "TBC1D11 binds RAB6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10565566", "species_10564844" ], "products": [ "species_10565568" ], "modifiers": [], "additional_components": [ "WBGene00018075", "Q22782", "WBGene00004270", "P34213", "WBGene00004269", "species_29438", "Q22782", "WBGene00004270", "P34213", "WBGene00004269", "species_29438", "H2KZZ6", "WBGene00018075" ] }, "reaction_10565591": { "compartment": "compartment_5683628", "id": "reaction_10565591", "reactome": "R-CEL-8854612", "name": "TBC1D25 accelerates GTP hydrolysis by RAB33B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10565586" ], "products": [ "species_29372", "species_10565588" ], "modifiers": [ [ "species_10565586", "catalyst" ] ], "additional_components": [ "species_29438", "Q20365", "WBGene00004283", "species_29420", "Q20365", "WBGene00004283", "species_29438", "Q20365", "WBGene00004283" ] }, "reaction_10565561": { "compartment": "compartment_262783", "id": "reaction_10565561", "reactome": "R-CEL-8854293", "name": "TBC1D10A (EPI64) binds ARF6:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10565550", "species_10565557" ], "products": [ "species_10565559" ], "modifiers": [], "additional_components": [ "WBGene00019915", "Q9U2S4", "WBGene00000184", "species_29438", "Q9U2S4", "WBGene00000184", "species_29438", "O44873", "WBGene00019915" ] }, "reaction_10565576": { "compartment": "compartment_17938", "id": "reaction_10565576", "reactome": "R-CEL-8854329", "name": "TBC1D15 accelerates GTP hydrolysis by RAB7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10565537" ], "products": [ "species_29372", "species_10565574" ], "modifiers": [ [ "species_10565537", "catalyst" ] ], "additional_components": [ "species_29438", "Q23146", "WBGene00004271", "species_29420", "Q23146", "WBGene00004271", "species_29438", "Q23146", "WBGene00004271" ] }, "reaction_10565547": { "compartment": "compartment_17938", "id": "reaction_10565547", "reactome": "R-CEL-8854255", "name": "TBC1D2A accelerates GTP hydrolysis by RAB7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10565537" ], "products": [ "species_29372", "species_10565539" ], "modifiers": [ [ "species_10565537", "catalyst" ], [ "species_10565545", "catalyst" ] ], "additional_components": [ "species_29438", "Q23146", "WBGene00004271", "species_29420", "Q23146", "WBGene00004271", "species_29438", "Q23146", "WBGene00004271", "WBGene00007849" ] }, "reaction_10565498": { "compartment": "compartment_24339", "id": "reaction_10565498", "reactome": "R-CEL-8854173", "name": "TBC RabGAPs accelerate GTP hydrolysis by RAB35", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10565475" ], "products": [ "species_29372", "species_10565477" ], "modifiers": [ [ "species_10565475", "catalyst" ], [ "species_10565496", "catalyst" ] ], "additional_components": [ "Q9U2C3", "WBGene00004284", "species_29438", "Q9U2C3", "WBGene00004284", "species_29420", "Q9U2C3", "WBGene00004284", "species_29438", "Q20436", "WBGene00009726", "H2KZ54", "WBGene00016292", "O44873", "WBGene00019915" ] }, "reaction_10565533": { "compartment": "compartment_171062", "id": "reaction_10565533", "reactome": "R-CEL-8854222", "name": "TBC1D3 associates with RAB5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10565501", "species_10565529" ], "products": [ "species_10565531" ], "modifiers": [], "additional_components": [ "WBGene00012894", "P91857", "WBGene00004268", "species_29438", "Q23165", "WBGene00000166", "A0A486WY48", "WBGene00012644", "P91857", "WBGene00004268", "species_29438", "Q23165", "WBGene00000166", "A0A486WY48", "WBGene00012644", "Q9U2D8", "WBGene00012894" ] }, "reaction_10565613": { "compartment": "compartment_262783", "id": "reaction_10565613", "reactome": "R-CEL-8854759", "name": "TBC1D14 binds RAB11 and ULK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10565609", "species_10565604", "species_10565602" ], "products": [ "species_10565611" ], "modifiers": [], "additional_components": [ "WBGene00044061", "WBGene00006786", "WBGene00004274", "O01803", "WBGene00004274", "Q23023", "WBGene00006786", "Q21928", "WBGene00044061" ] }, "reaction_10554302": { "compartment": "compartment_7660", "id": "reaction_10554302", "reactome": "R-CEL-5653838", "name": "POLD,POLE binds deISGylated PCNA after TLS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10554298", "species_10508801" ], "products": [ "species_10554300" ], "modifiers": [], "additional_components": [ "Q95Y97", "WBGene00019767", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "O02115", "WBGene00003955", "P90829", "WBGene00008645", "Q19366", "WBGene00008722", "Q21730", "WBGene00011016", "P90829", "WBGene00008645", "Q19366", "WBGene00008722", "Q21730", "WBGene00011016", "Q95Y97", "WBGene00019767", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "O02115", "WBGene00003955" ] }, "reaction_10551331": { "compartment": "compartment_263163", "id": "reaction_10551331", "reactome": "R-CEL-5333658", "name": "CLAT:AP1:CLVS bind PI(3,5)P2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10551327", "species_5334668" ], "products": [ "species_10551329" ], "modifiers": [], "additional_components": [ "P35602", "WBGene00006829", "O01755", "WBGene00000150", "O16369", "WBGene00000159", "Q9N4F3", "WBGene00000160", "Q8WQB3", "WBGene00000158", "P34574", "WBGene00011867", "species_5334668", "P35602", "WBGene00006829", "O01755", "WBGene00000150", "O16369", "WBGene00000159", "Q9N4F3", "WBGene00000160", "Q8WQB3", "WBGene00000158", "P34574", "WBGene00011867" ] }, "reaction_10524037": { "compartment": "compartment_70101", "id": "reaction_10524037", "reactome": "R-CEL-432706", "name": "trans-Golgi Network Lysosome Vesicle Destined Membrane Coat Assembly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10524031", "species_10522248", "species_10512231", "species_10522246" ], "products": [ "species_10517983", "species_29372", "species_10524035" ], "modifiers": [], "additional_components": [ "Q8WQB3", "WBGene00000158", "O01755", "WBGene00000150", "P35602", "WBGene00006829", "O16369", "WBGene00000159", "Q9N4F3", "WBGene00000160", "P51485", "WBGene00000195", "G5EFK4", "WBGene00000183", "species_29438", "WBGene00001130", "WBGene00006791", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "species_29420", "G5EFK4", "WBGene00000183", "Q8WQB3", "WBGene00000158", "O01755", "WBGene00000150", "P35602", "WBGene00006829", "O16369", "WBGene00000159", "Q9N4F3", "WBGene00000160", "P51485", "WBGene00000195", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "B1V8A0", "WBGene00006791", "P39055", "WBGene00001130" ] }, "reaction_10524040": { "compartment": "compartment_70101", "id": "reaction_10524040", "reactome": "R-CEL-432707", "name": "trans-Golgi Network Lysosomal Vesicle Scission", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10524035" ], "products": [ "species_29372", "species_29420", "species_10522248", "species_10512231", "species_10524001" ], "modifiers": [ [ "species_10524035", "catalyst" ] ], "additional_components": [ "Q8WQB3", "WBGene00000158", "O01755", "WBGene00000150", "P35602", "WBGene00006829", "O16369", "WBGene00000159", "Q9N4F3", "WBGene00000160", "P51485", "WBGene00000195", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "B1V8A0", "WBGene00006791", "P39055", "WBGene00001130", "WBGene00001130", "WBGene00006791", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "O01755", "WBGene00000150", "P35602", "WBGene00006829", "O16369", "WBGene00000159", "Q8WQB3", "WBGene00000158", "Q9N4F3", "WBGene00000160", "P51485", "WBGene00000195", "Q8WQB3", "WBGene00000158", "O01755", "WBGene00000150", "P35602", "WBGene00006829", "O16369", "WBGene00000159", "Q9N4F3", "WBGene00000160", "P51485", "WBGene00000195", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "B1V8A0", "WBGene00006791", "P39055", "WBGene00001130" ] }, "reaction_10554828": { "compartment": "compartment_20699", "id": "reaction_10554828", "reactome": "R-CEL-5671702", "name": "AP1G2 binds HGS and CHMP2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10554824", "species_10529030", "species_10512214" ], "products": [ "species_10554826" ], "modifiers": [], "additional_components": [ "WBGene00000158", "WBGene00012903", "WBGene00004101", "Q9U2F6", "WBGene00012903", "Q17796", "WBGene00004101", "Q8WQB3", "WBGene00000158" ] }, "reaction_10518097": { "compartment": "compartment_13231", "id": "reaction_10518097", "reactome": "R-CEL-351947", "name": "Nuclear translocation of catalytic domain of Mst3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10518081" ], "products": [ "species_10518095" ], "modifiers": [], "additional_components": [ "WBGene00001526", "WBGene00001526" ] }, "reaction_10518085": { "compartment": "compartment_70101", "id": "reaction_10518085", "reactome": "R-CEL-351901", "name": "Caspase-mediated cleavage of MST3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10518079" ], "products": [ "species_10518083", "species_10518081" ], "modifiers": [ [ "species_10509422", "catalyst" ] ], "additional_components": [ "WBGene00001526", "WBGene00001526", "WBGene00001526", "P42573", "WBGene00000417" ] }, "reaction_10515329": { "compartment": "compartment_70101", "id": "reaction_10515329", "reactome": "R-CEL-202917", "name": "Caspase-mediated cleavage of Desmoglein 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10515323" ], "products": [ "species_10515327", "species_10515325" ], "modifiers": [ [ "species_10509422", "catalyst" ] ], "additional_components": [ "WBGene00000396", "WBGene00000396", "WBGene00000396", "P42573", "WBGene00000417" ] }, "reaction_10514849": { "compartment": "compartment_876", "id": "reaction_10514849", "reactome": "R-CEL-201595", "name": "Caspase-mediated cleavage of plakophilin-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10514844" ], "products": [ "species_10514846" ], "modifiers": [ [ "species_10509422", "catalyst" ] ], "additional_components": [ "WBGene00002175", "WBGene00002175", "P42573", "WBGene00000417" ] }, "reaction_10518066": { "compartment": "compartment_876", "id": "reaction_10518066", "reactome": "R-CEL-351877", "name": "Caspase-mediated cleavage of Desmoglein 2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10518062" ], "products": [ "species_10518064" ], "modifiers": [ [ "species_10509422", "catalyst" ] ], "additional_components": [ "WBGene00000396", "WBGene00000396", "P42573", "WBGene00000417" ] }, "reaction_10518052": { "compartment": "compartment_876", "id": "reaction_10518052", "reactome": "R-CEL-351871", "name": "Caspase-mediated cleavage of Z0-2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10518048" ], "products": [ "species_10518050" ], "modifiers": [ [ "species_10509422", "catalyst" ] ], "additional_components": [ "WBGene00013683", "WBGene00013683", "P42573", "WBGene00000417" ] }, "reaction_10514901": { "compartment": "compartment_70101", "id": "reaction_10514901", "reactome": "R-CEL-201631", "name": "Caspase-mediated cleavage of Desmoglein 3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10514895" ], "products": [ "species_10514899", "species_10514897" ], "modifiers": [ [ "species_10509422", "catalyst" ] ], "additional_components": [ "WBGene00000396", "WBGene00000396", "WBGene00000396", "P42573", "WBGene00000417" ] }, "reaction_10515367": { "compartment": "compartment_70101", "id": "reaction_10515367", "reactome": "R-CEL-202969", "name": "Caspase mediated cleavage of beta-catenin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10515361" ], "products": [ "species_10515365", "species_10515363" ], "modifiers": [ [ "species_10509422", "catalyst" ] ], "additional_components": [ "WBGene00001979", "WBGene00001979", "P42573", "WBGene00000417" ] }, "reaction_10514919": { "compartment": "compartment_70101", "id": "reaction_10514919", "reactome": "R-CEL-201636", "name": "Caspase-mediated cleavage of Desmoplakin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10514915" ], "products": [ "species_10514917" ], "modifiers": [ [ "species_10509422", "catalyst" ] ], "additional_components": [ "WBGene00006876", "WBGene00006876", "P42573", "WBGene00000417" ] }, "reaction_10518089": { "compartment": "compartment_876", "id": "reaction_10518089", "reactome": "R-CEL-351913", "name": "Caspase-mediated cleavage of TJP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10518087" ], "products": [ "species_10518050" ], "modifiers": [ [ "species_10509422", "catalyst" ] ], "additional_components": [ "WBGene00013683", "WBGene00013683", "P42573", "WBGene00000417" ] }, "reaction_10518060": { "compartment": "compartment_70101", "id": "reaction_10518060", "reactome": "R-CEL-351876", "name": "Caspase-mediated cleavage of occludin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10518054" ], "products": [ "species_10518058", "species_10518056" ], "modifiers": [ [ "species_10509422", "catalyst" ] ], "additional_components": [ "WBGene00021281", "WBGene00021281", "WBGene00021281", "P42573", "WBGene00000417" ] }, "reaction_10514936": { "compartment": "compartment_70101", "id": "reaction_10514936", "reactome": "R-CEL-201640", "name": "Caspase-mediated cleavage of farnesyltransferase/geranyl- geranyltransferase subunit alpha ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10514930" ], "products": [ "species_10514934", "species_10514932" ], "modifiers": [ [ "species_10509422", "catalyst" ] ], "additional_components": [ "WBGene00019823", "WBGene00019823", "WBGene00019823", "P42573", "WBGene00000417" ] }, "reaction_10517976": { "compartment": "compartment_70101", "id": "reaction_10517976", "reactome": "R-CEL-350651", "name": "Caspase-mediated cleavage of MASK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10517970" ], "products": [ "species_10517974", "species_10517972" ], "modifiers": [ [ "species_10509422", "catalyst" ] ], "additional_components": [ "WBGene00001526", "WBGene00001526", "WBGene00001526", "P42573", "WBGene00000417" ] }, "reaction_10515337": { "compartment": "compartment_70101", "id": "reaction_10515337", "reactome": "R-CEL-202947", "name": "Caspase mediated cleavage of APC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10515331" ], "products": [ "species_10515335", "species_10515333" ], "modifiers": [ [ "species_10509422", "catalyst" ] ], "additional_components": [ "WBGene00000156", "WBGene00000156", "WBGene00000156", "P42573", "WBGene00000417" ] }, "reaction_10517161": { "compartment": "compartment_70101", "id": "reaction_10517161", "reactome": "R-CEL-212552", "name": "Caspase 3-mediated cleavage of PKC delta", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10509049" ], "products": [ "species_10517159", "species_10517157" ], "modifiers": [ [ "species_10509422", "catalyst" ] ], "additional_components": [ "WBGene00006599", "WBGene00006599", "WBGene00006599", "P42573", "WBGene00000417" ] }, "reaction_10514857": { "compartment": "compartment_70101", "id": "reaction_10514857", "reactome": "R-CEL-201603", "name": "Caspase-mediated cleavage of PKC theta", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10514851" ], "products": [ "species_10514855", "species_10514853" ], "modifiers": [ [ "species_10509422", "catalyst" ] ], "additional_components": [ "WBGene00006599", "WBGene00006599", "WBGene00006599", "P42573", "WBGene00000417" ] }, "reaction_10514890": { "compartment": "compartment_70101", "id": "reaction_10514890", "reactome": "R-CEL-201630", "name": "Caspase-mediated cleavage of Acinus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10514884" ], "products": [ "species_10514888", "species_10514886" ], "modifiers": [ [ "species_10509422", "catalyst" ] ], "additional_components": [ "WBGene00016601", "WBGene00016601", "WBGene00016601", "P42573", "WBGene00000417" ] }, "reaction_10514879": { "compartment": "compartment_70101", "id": "reaction_10514879", "reactome": "R-CEL-201611", "name": "Caspase-mediated cleavage of Rock-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10514873" ], "products": [ "species_10514877", "species_10514875" ], "modifiers": [ [ "species_10509422", "catalyst" ] ], "additional_components": [ "WBGene00002694", "WBGene00002694", "WBGene00002694", "P42573", "WBGene00000417" ] }, "reaction_10518106": { "compartment": "compartment_70101", "id": "reaction_10518106", "reactome": "R-CEL-351948", "name": "Mitochondrial recruitment of Drp1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10518102" ], "products": [ "species_10518104" ], "modifiers": [ [ "species_10518073", "catalyst" ] ], "additional_components": [ "WBGene00001093", "WBGene00001093", "WBGene00021883" ] }, "reaction_10512852": { "compartment": "compartment_876", "id": "reaction_10512852", "reactome": "R-CEL-189242", "name": "SLC2A2 tetramer transports Fru, Gal, Glc from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189246" ], "products": [ "species_189219" ], "modifiers": [ [ "species_10512849", "catalyst" ] ], "additional_components": [ "species_70113", "species_188995", "species_29532", "species_188995", "species_70113", "species_29532", "Q23626", "WBGene00022014", "Q95QY6", "WBGene00022014", "Q9GPA2", "WBGene00022014", "Q9N309", "WBGene00022014", "Q9U2K5", "WBGene00022014", "Q9XU83", "WBGene00022014", "Q9XVL3", "WBGene00022014", "G5EC93", "WBGene00022014", "O16547", "WBGene00022014", "O44616", "WBGene00022014", "O44827", "WBGene00019207", "O45920", "WBGene00022014", "Q11114", "WBGene00022014", "Q19376", "WBGene00022014", "Q20734", "WBGene00022014", "Q23535", "WBGene00006865" ] }, "reaction_10512813": { "compartment": "compartment_876", "id": "reaction_10512813", "reactome": "R-CEL-189222", "name": "SLC2A5 transports fructose from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189049" ], "products": [ "species_29532" ], "modifiers": [ [ "species_10512810", "catalyst" ] ], "additional_components": [ "Q20734", "WBGene00022014", "O16547", "WBGene00022014", "Q9XU83", "WBGene00022014", "Q23535", "WBGene00006865", "O44616", "WBGene00022014", "Q9XVL3", "WBGene00022014", "Q23626", "WBGene00022014", "O44827", "WBGene00019207", "Q95QY6", "WBGene00022014", "O45920", "WBGene00022014", "Q9GPA2", "WBGene00022014", "Q11114", "WBGene00022014", "Q9N309", "WBGene00022014", "Q19376", "WBGene00022014", "G5EC93", "WBGene00022014", "Q9U2K5", "WBGene00022014" ] }, "reaction_10554240": { "compartment": "compartment_7660", "id": "reaction_10554240", "reactome": "R-CEL-5652009", "name": "RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502318", "species_10554233" ], "products": [ "species_10554237", "species_10554231", "species_10508801" ], "modifiers": [ [ "species_10554233", "catalyst" ] ], "additional_components": [ "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "Q95Y97", "WBGene00019767", "P90829", "WBGene00008645", "Q19366", "WBGene00008722", "Q21730", "WBGene00011016", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "O02115", "WBGene00003955", "Q21554", "WBGene00010890", "Q23457", "WBGene00004320", "Q22059", "WBGene00011318", "Q17392", "WBGene00000839", "Q95Y97", "WBGene00019767", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "O02115", "WBGene00003955", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "Q21554", "WBGene00010890", "Q23457", "WBGene00004320", "Q22059", "WBGene00011318", "Q17392", "WBGene00000839", "P90829", "WBGene00008645", "Q19366", "WBGene00008722", "Q21730", "WBGene00011016", "Q95Y97", "WBGene00019767", "P90829", "WBGene00008645", "Q19366", "WBGene00008722", "Q21730", "WBGene00011016", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "O02115", "WBGene00003955", "Q21554", "WBGene00010890", "Q23457", "WBGene00004320", "Q22059", "WBGene00011318", "Q17392", "WBGene00000839" ] }, "reaction_10554235": { "compartment": "compartment_7660", "id": "reaction_10554235", "reactome": "R-CEL-5652005", "name": "RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10554231", "species_10554212" ], "products": [ "species_10554233" ], "modifiers": [], "additional_components": [ "Q21554", "WBGene00010890", "Q23457", "WBGene00004320", "Q22059", "WBGene00011318", "Q17392", "WBGene00000839", "Q95Y97", "WBGene00019767", "P90829", "WBGene00008645", "Q19366", "WBGene00008722", "Q21730", "WBGene00011016", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "O02115", "WBGene00003955", "Q95Y97", "WBGene00019767", "P90829", "WBGene00008645", "Q19366", "WBGene00008722", "Q21730", "WBGene00011016", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "O02115", "WBGene00003955", "Q21554", "WBGene00010890", "Q23457", "WBGene00004320", "Q22059", "WBGene00011318", "Q17392", "WBGene00000839" ] }, "reaction_10554419": { "compartment": "compartment_7660", "id": "reaction_10554419", "reactome": "R-CEL-5654989", "name": "SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10554410" ], "products": [ "species_113582", "species_10508757", "species_10554416" ], "modifiers": [ [ "species_10554410", "catalyst" ] ], "additional_components": [ "Q22557", "WBGene00011834", "Q95Y97", "WBGene00019767", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "O02115", "WBGene00003955", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "G5EFY1", "WBGene00018721", "Q95QZ9", "WBGene00019121", "Q19584", "WBGene00006733", "P54812", "WBGene00008053", "WBGene00018721", "Q95Y97", "WBGene00019767", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "O02115", "WBGene00003955", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "Q22557", "WBGene00011834", "Q95QZ9", "WBGene00019121", "Q19584", "WBGene00006733", "P54812", "WBGene00008053", "Q22557", "WBGene00011834", "Q95Y97", "WBGene00019767", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "O02115", "WBGene00003955", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "G5EFY1", "WBGene00018721", "Q95QZ9", "WBGene00019121", "Q19584", "WBGene00006733", "P54812", "WBGene00008053" ] }, "reaction_10508774": { "compartment": "compartment_7660", "id": "reaction_10508774", "reactome": "R-CEL-110317", "name": "Insertion of correct bases opposite the lesion by POLH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508763", "species_29604" ], "products": [ "species_113541", "species_10508771" ], "modifiers": [ [ "species_10508763", "catalyst" ] ], "additional_components": [ "G5EFY1", "WBGene00018721", "Q95Y97", "WBGene00019767", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "O02115", "WBGene00003955", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "Q95Y97", "WBGene00019767", "O02115", "WBGene00003955", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "G5EFY1", "WBGene00018721", "G5EFY1", "WBGene00018721", "Q95Y97", "WBGene00019767", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "O02115", "WBGene00003955", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725" ] }, "reaction_10508765": { "compartment": "compartment_7660", "id": "reaction_10508765", "reactome": "R-CEL-110316", "name": "POLH binds monoUb:K164-PCNA at damaged TT-CPD-DNA template", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508761", "species_10508757" ], "products": [ "species_10508763" ], "modifiers": [], "additional_components": [ "Q95Y97", "WBGene00019767", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "O02115", "WBGene00003955", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "WBGene00018721", "G5EFY1", "WBGene00018721", "Q95Y97", "WBGene00019767", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "O02115", "WBGene00003955", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725" ] }, "reaction_10508781": { "compartment": "compartment_7660", "id": "reaction_10508781", "reactome": "R-CEL-110319", "name": "Elongation by POLH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30555", "species_10508771" ], "products": [ "species_10508778", "species_113541" ], "modifiers": [ [ "species_10508771", "catalyst" ] ], "additional_components": [ "Q95Y97", "WBGene00019767", "O02115", "WBGene00003955", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "G5EFY1", "WBGene00018721", "Q95Y97", "WBGene00019767", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "O02115", "WBGene00003955", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "G5EFY1", "WBGene00018721", "Q95Y97", "WBGene00019767", "O02115", "WBGene00003955", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "G5EFY1", "WBGene00018721" ] }, "reaction_10554412": { "compartment": "compartment_7660", "id": "reaction_10554412", "reactome": "R-CEL-5654985", "name": "SPRTN recruits VCP to monoUb:K164-PCNA associated with POLH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10554408", "species_10554392" ], "products": [ "species_10554410" ], "modifiers": [], "additional_components": [ "Q95QZ9", "WBGene00019121", "Q19584", "WBGene00006733", "P54812", "WBGene00008053", "Q22557", "WBGene00011834", "Q95Y97", "WBGene00019767", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "O02115", "WBGene00003955", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "G5EFY1", "WBGene00018721", "Q22557", "WBGene00011834", "Q95Y97", "WBGene00019767", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "O02115", "WBGene00003955", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "G5EFY1", "WBGene00018721", "Q95QZ9", "WBGene00019121", "Q19584", "WBGene00006733", "P54812", "WBGene00008053" ] }, "reaction_10554414": { "compartment": "compartment_7660", "id": "reaction_10554414", "reactome": "R-CEL-5654986", "name": "SPRTN binds monoUb:K164-PCNA associated with POLH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508778", "species_10554390" ], "products": [ "species_10554392" ], "modifiers": [], "additional_components": [ "Q95Y97", "WBGene00019767", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "O02115", "WBGene00003955", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "G5EFY1", "WBGene00018721", "WBGene00011834", "Q22557", "WBGene00011834", "Q95Y97", "WBGene00019767", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "O02115", "WBGene00003955", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "G5EFY1", "WBGene00018721" ] }, "reaction_10556021": { "compartment": "compartment_7660", "id": "reaction_10556021", "reactome": "R-CEL-5687664", "name": "FEN1 cleaves displaced ssDNA flaps during MMEJ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10556014" ], "products": [ "species_68454", "species_10502724", "species_10556018" ], "modifiers": [ [ "species_10556014", "catalyst" ] ], "additional_components": [ "Q9N3T2", "WBGene00000794", "Q18606", "WBGene00008082", "Q23255", "WBGene00003405", "O44199", "WBGene00004296", "WBGene00000794", "Q23255", "WBGene00003405", "O44199", "WBGene00004296", "Q18606", "WBGene00008082", "Q9N3T2", "WBGene00000794", "Q18606", "WBGene00008082", "Q23255", "WBGene00003405", "O44199", "WBGene00004296" ] }, "reaction_10556008": { "compartment": "compartment_7660", "id": "reaction_10556008", "reactome": "R-CEL-5687464", "name": "MRN and RBBP8 resect DNA DSBs in MMEJ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10556001" ], "products": [ "species_30555", "species_10556005" ], "modifiers": [ [ "species_10556001", "catalyst" ] ], "additional_components": [ "Q18606", "WBGene00008082", "Q23255", "WBGene00003405", "O44199", "WBGene00004296", "Q23255", "WBGene00003405", "O44199", "WBGene00004296", "Q18606", "WBGene00008082", "Q18606", "WBGene00008082", "Q23255", "WBGene00003405", "O44199", "WBGene00004296" ] }, "reaction_10519896": { "compartment": "compartment_5460", "id": "reaction_10519896", "reactome": "R-CEL-380608", "name": "5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113526", "species_380598" ], "products": [ "species_113529", "species_380593", "species_29362" ], "modifiers": [ [ "species_10504264", "catalyst" ] ], "additional_components": [ "Q20780", "WBGene00000107" ] }, "reaction_10524588": { "compartment": "compartment_876", "id": "reaction_10524588", "reactome": "R-CEL-444008", "name": "SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_188972", "species_114523", "species_74113" ], "products": [ "species_209914", "species_83910", "species_352022" ], "modifiers": [ [ "species_10524585", "catalyst" ] ], "additional_components": [ "WBGene00003387" ] }, "reaction_10517995": { "compartment": "compartment_70101", "id": "reaction_10517995", "reactome": "R-CEL-350769", "name": "trans-Golgi Network Coat Activation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10517983", "species_29438" ], "products": [ "species_29420", "species_10517987" ], "modifiers": [ [ "species_10517992", "catalyst" ] ], "additional_components": [ "species_29420", "G5EFK4", "WBGene00000183", "G5EFK4", "WBGene00000183", "species_29438", "WBGene00007703" ] }, "reaction_10522258": { "compartment": "compartment_20699", "id": "reaction_10522258", "reactome": "R-CEL-421831", "name": "trans-Golgi Network Coat Assembly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10522248", "species_10512231", "species_10522246", "species_10522240" ], "products": [ "species_10517983", "species_29372", "species_10522256" ], "modifiers": [], "additional_components": [ "WBGene00001130", "WBGene00006791", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "Q8WQB3", "WBGene00000158", "O01755", "WBGene00000150", "P35602", "WBGene00006829", "O16369", "WBGene00000159", "Q9N4F3", "WBGene00000160", "P51485", "WBGene00000195", "G5EFK4", "WBGene00000183", "species_29438", "species_29420", "G5EFK4", "WBGene00000183", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "B1V8A0", "WBGene00006791", "Q8WQB3", "WBGene00000158", "O01755", "WBGene00000150", "P35602", "WBGene00006829", "O16369", "WBGene00000159", "Q9N4F3", "WBGene00000160", "P51485", "WBGene00000195", "P39055", "WBGene00001130" ] }, "reaction_10522389": { "compartment": "compartment_70101", "id": "reaction_10522389", "reactome": "R-CEL-421835", "name": "trans-Golgi Network Vesicle Scission", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10522256" ], "products": [ "species_29372", "species_29420", "species_10522248", "species_10512231", "species_10522386" ], "modifiers": [ [ "species_10522256", "catalyst" ] ], "additional_components": [ "P34574", "WBGene00011867", "P90961", "WBGene00020246", "B1V8A0", "WBGene00006791", "Q8WQB3", "WBGene00000158", "O01755", "WBGene00000150", "P35602", "WBGene00006829", "O16369", "WBGene00000159", "Q9N4F3", "WBGene00000160", "P51485", "WBGene00000195", "P39055", "WBGene00001130", "WBGene00001130", "WBGene00006791", "P51485", "WBGene00000195", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "P35602", "WBGene00006829", "O01755", "WBGene00000150", "O16369", "WBGene00000159", "Q8WQB3", "WBGene00000158", "Q9N4F3", "WBGene00000160", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "B1V8A0", "WBGene00006791", "Q8WQB3", "WBGene00000158", "O01755", "WBGene00000150", "P35602", "WBGene00006829", "O16369", "WBGene00000159", "Q9N4F3", "WBGene00000160", "P51485", "WBGene00000195", "P39055", "WBGene00001130" ] }, "reaction_10566464": { "compartment": "compartment_876", "id": "reaction_10566464", "reactome": "R-CEL-8867756", "name": "CLASP proteins and cargo are recruited to the nascent clathrin-coated pit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10566399", "species_10565777" ], "products": [ "species_10566401" ], "modifiers": [], "additional_components": [ "Q95XH1", "WBGene00022077", "G5EBK2", "WBGene00014084", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q19767", "WBGene00004898", "Q94057", "WBGene00044062", "Q9XZI6", "WBGene00006751", "Q9N532", "WBGene00003238", "G5EDV1", "WBGene00003006", "P34889", "WBGene00000858", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "Q9U7D5", "WBGene00001519", "P51485", "WBGene00000195", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "P90761", "WBGene00006777", "Q9BIF4", "WBGene00001224", "Q18453", "WBGene00004682", "Q9BI71", "WBGene00001329", "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "B1V8A0", "WBGene00006791", "P29355", "WBGene00004774", "Q17796", "WBGene00004101", "O01498", "WBGene00004109", "Q21496", "WBGene00020010", "Q21948", "WBGene00020010", "A0A486WXX8", "WBGene00000894", "Q95QV2", "WBGene00000477", "Q19625", "WBGene00003412", "P34711", "WBGene00006756", "Q9XTT3", "WBGene00013039", "G5ECQ3", "WBGene00004762", "Q20483", "WBGene00018516", "Q9BIF4", "WBGene00001224", "species_179856", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "Q9TXS0", "WBGene00018974", "Q9N489", "WBGene00022453", "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "Q19123", "WBGene00000157", "P35603", "WBGene00001082", "A0A0K3AS36", "Y116A8C.36d", "G5ECQ3", "WBGene00004762", "Q20483", "WBGene00018516", "Q9BIF4", "WBGene00001224", "species_179856", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "Q9TXS0", "WBGene00018974", "Q9N489", "WBGene00022453", "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "Q19123", "WBGene00000157", "P35603", "WBGene00001082", "A0A0K3AS36", "Y116A8C.36d", "Q95XH1", "WBGene00022077", "G5EBK2", "WBGene00014084", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q19767", "WBGene00004898", "Q94057", "WBGene00044062", "Q9XZI6", "WBGene00006751", "Q9N532", "WBGene00003238", "G5EDV1", "WBGene00003006", "P34889", "WBGene00000858", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "Q9U7D5", "WBGene00001519", "P51485", "WBGene00000195", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "P90761", "WBGene00006777", "Q18453", "WBGene00004682", "Q9BI71", "WBGene00001329", "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "B1V8A0", "WBGene00006791", "P29355", "WBGene00004774", "Q17796", "WBGene00004101", "O01498", "WBGene00004109", "Q21496", "WBGene00020010", "Q21948", "WBGene00020010", "A0A486WXX8", "WBGene00000894", "Q95QV2", "WBGene00000477", "Q19625", "WBGene00003412", "P34711", "WBGene00006756", "Q9XTT3", "WBGene00013039" ] }, "reaction_10567111": { "compartment": "compartment_24339", "id": "reaction_10567111", "reactome": "R-CEL-8871193", "name": "Dissociation of AAK1 and dephosphorylation of AP-2 mu2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10567109" ], "products": [ "species_10566724", "species_10565728" ], "modifiers": [], "additional_components": [ "P91857", "WBGene00004268", "species_29420", "Q9GYH7", "WBGene00004377", "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q9XTT3", "WBGene00013039", "Q19625", "WBGene00003412", "Q95QV2", "WBGene00000477", "P34711", "WBGene00006756", "Q21496", "WBGene00020010", "Q21948", "WBGene00020010", "A0A486WXX8", "WBGene00000894", "O02495", "WBGene00004897", "G5EBK2", "WBGene00014084", "P34351", "WBGene00004899", "Q19767", "WBGene00004898", "Q94057", "WBGene00044062", "Q95XH1", "WBGene00022077", "Q9XZI6", "WBGene00006751", "Q9BIF4", "WBGene00001224", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "B1V8A0", "WBGene00006791", "Q18453", "WBGene00004682", "Q9BI71", "WBGene00001329", "P29355", "WBGene00004774", "Q17796", "WBGene00004101", "O01498", "WBGene00004109", "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "P34889", "WBGene00000858", "G5EDV1", "WBGene00003006", "Q9N532", "WBGene00003238", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "Q9U7D5", "WBGene00001519", "P51485", "WBGene00000195", "P90761", "WBGene00006777", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "Q02328", "WBGene00022717", "G5ECQ3", "WBGene00004762", "Q20483", "WBGene00018516", "P0DM42", "WBGene00000065", "P10984", "WBGene00000064", "P10986", "WBGene00000066", "P0DM41", "WBGene00000063", "species_29358", "Q19253", "WBGene00017298", "P58798", "WBGene00000204", "A0A3P6PCS5", "WBGene00000201", "Q9N4I0", "WBGene00000199", "Q8WTM6", "WBGene00021170", "P53489", "WBGene00000200", "Q9XWV3", "WBGene00000203", "O61861", "WBGene00000205", "P91167", "WBGene00016729", "species_1806234", "Q21004", "WBGene00010272", "Q9XUS7", "WBGene00010663", "Q9TXS0", "WBGene00018974", "A0A486WXP9", "WBGene00001043", "Q6AHQ8", "WBGene00018467", "Q9N489", "WBGene00022453", "Q8I4E2", "WBGene00003086", "A0A0K3AS36", "Y116A8C.36d", "P39055", "WBGene00001130", "O17590", "WBGene00007620", "G5ECL2", "WBGene00006763", "P91857", "WBGene00004268", "species_29438", "Q9GYH7", "WBGene00004377", "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q9XTT3", "WBGene00013039", "Q19625", "WBGene00003412", "Q95QV2", "WBGene00000477", "P34711", "WBGene00006756", "Q21496", "WBGene00020010", "Q21948", "WBGene00020010", "A0A486WXX8", "WBGene00000894", "O02495", "WBGene00004897", "G5EBK2", "WBGene00014084", "P34351", "WBGene00004899", "Q19767", "WBGene00004898", "Q94057", "WBGene00044062", "Q95XH1", "WBGene00022077", "Q9XZI6", "WBGene00006751", "Q9BIF4", "WBGene00001224", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "B1V8A0", "WBGene00006791", "Q18453", "WBGene00004682", "Q9BI71", "WBGene00001329", "P29355", "WBGene00004774", "Q17796", "WBGene00004101", "O01498", "WBGene00004109", "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "P34889", "WBGene00000858", "G5EDV1", "WBGene00003006", "Q9N532", "WBGene00003238", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "Q9U7D5", "WBGene00001519", "P51485", "WBGene00000195", "P90761", "WBGene00006777", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "Q02328", "WBGene00022717", "P0DM42", "WBGene00000065", "P10984", "WBGene00000064", "P10986", "WBGene00000066", "P0DM41", "WBGene00000063", "species_29358", "Q19253", "WBGene00017298", "P58798", "WBGene00000204", "A0A3P6PCS5", "WBGene00000201", "Q9N4I0", "WBGene00000199", "Q8WTM6", "WBGene00021170", "P53489", "WBGene00000200", "Q9XWV3", "WBGene00000203", "O61861", "WBGene00000205", "P91167", "WBGene00016729", "species_1806234", "Q21004", "WBGene00010272", "Q9XUS7", "WBGene00010663", "Q9TXS0", "WBGene00018974", "A0A486WXP9", "WBGene00001043", "Q6AHQ8", "WBGene00018467", "Q9N489", "WBGene00022453", "Q8I4E2", "WBGene00003086", "A0A0K3AS36", "Y116A8C.36d", "P39055", "WBGene00001130", "species_29420", "O17590", "WBGene00007620", "G5ECL2", "WBGene00006763", "G5ECQ3", "WBGene00004762", "Q20483", "WBGene00018516" ] }, "reaction_10565769": { "compartment": "compartment_876", "id": "reaction_10565769", "reactome": "R-CEL-8856808", "name": "Recruitment of AP-2 complex and clathrin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10548814", "species_10565757", "species_10565755", "species_10522246", "species_10565728" ], "products": [ "species_10565761" ], "modifiers": [ [ "species_10565767", "catalyst" ] ], "additional_components": [ "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "WBGene00022453", "Q9BIF4", "WBGene00001224", "species_179856", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q9TXS0", "WBGene00018974", "A0A0K3AS36", "Y116A8C.36d", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "G5ECQ3", "WBGene00004762", "Q20483", "WBGene00018516", "G5ECQ3", "WBGene00004762", "Q20483", "WBGene00018516", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "Q9BIF4", "WBGene00001224", "species_179856", "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q9TXS0", "WBGene00018974", "A0A0K3AS36", "Y116A8C.36d", "Q9N489", "WBGene00022453", "Q9U2S4", "WBGene00000184", "species_29438", "P90904", "WBGene00010500" ] }, "reaction_10567113": { "compartment": "compartment_24339", "id": "reaction_10567113", "reactome": "R-CEL-8871194", "name": "RAB5 and GAPVD1 bind AP-2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10566661", "species_10567107" ], "products": [ "species_10567109" ], "modifiers": [], "additional_components": [ "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q9XTT3", "WBGene00013039", "Q19625", "WBGene00003412", "Q95QV2", "WBGene00000477", "P34711", "WBGene00006756", "Q21496", "WBGene00020010", "Q21948", "WBGene00020010", "A0A486WXX8", "WBGene00000894", "O02495", "WBGene00004897", "G5EBK2", "WBGene00014084", "P34351", "WBGene00004899", "Q19767", "WBGene00004898", "Q94057", "WBGene00044062", "Q95XH1", "WBGene00022077", "Q9XZI6", "WBGene00006751", "Q9BIF4", "WBGene00001224", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "B1V8A0", "WBGene00006791", "Q18453", "WBGene00004682", "Q9BI71", "WBGene00001329", "P29355", "WBGene00004774", "Q17796", "WBGene00004101", "O01498", "WBGene00004109", "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "P34889", "WBGene00000858", "G5EDV1", "WBGene00003006", "Q9N532", "WBGene00003238", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "Q9U7D5", "WBGene00001519", "P51485", "WBGene00000195", "P90761", "WBGene00006777", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "Q02328", "WBGene00022717", "G5ECQ3", "WBGene00004762", "Q20483", "WBGene00018516", "P0DM42", "WBGene00000065", "P10984", "WBGene00000064", "P10986", "WBGene00000066", "P0DM41", "WBGene00000063", "species_29358", "Q19253", "WBGene00017298", "P58798", "WBGene00000204", "A0A3P6PCS5", "WBGene00000201", "Q9N4I0", "WBGene00000199", "Q8WTM6", "WBGene00021170", "P53489", "WBGene00000200", "Q9XWV3", "WBGene00000203", "O61861", "WBGene00000205", "P91167", "WBGene00016729", "species_1806234", "Q21004", "WBGene00010272", "Q9XUS7", "WBGene00010663", "Q9TXS0", "WBGene00018974", "A0A486WXP9", "WBGene00001043", "Q6AHQ8", "WBGene00018467", "Q9N489", "WBGene00022453", "Q8I4E2", "WBGene00003086", "A0A0K3AS36", "Y116A8C.36d", "P39055", "WBGene00001130", "species_29420", "O17590", "WBGene00007620", "G5ECL2", "WBGene00006763", "P91857", "WBGene00004268", "species_29420", "Q9GYH7", "WBGene00004377", "P91857", "WBGene00004268", "species_29420", "Q9GYH7", "WBGene00004377", "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q9XTT3", "WBGene00013039", "Q19625", "WBGene00003412", "Q95QV2", "WBGene00000477", "P34711", "WBGene00006756", "Q21496", "WBGene00020010", "Q21948", "WBGene00020010", "A0A486WXX8", "WBGene00000894", "O02495", "WBGene00004897", "G5EBK2", "WBGene00014084", "P34351", "WBGene00004899", "Q19767", "WBGene00004898", "Q94057", "WBGene00044062", "Q95XH1", "WBGene00022077", "Q9XZI6", "WBGene00006751", "Q9BIF4", "WBGene00001224", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "B1V8A0", "WBGene00006791", "Q18453", "WBGene00004682", "Q9BI71", "WBGene00001329", "P29355", "WBGene00004774", "Q17796", "WBGene00004101", "O01498", "WBGene00004109", "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "P34889", "WBGene00000858", "G5EDV1", "WBGene00003006", "Q9N532", "WBGene00003238", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "Q9U7D5", "WBGene00001519", "P51485", "WBGene00000195", "P90761", "WBGene00006777", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "Q02328", "WBGene00022717", "G5ECQ3", "WBGene00004762", "Q20483", "WBGene00018516", "P0DM42", "WBGene00000065", "P10984", "WBGene00000064", "P10986", "WBGene00000066", "P0DM41", "WBGene00000063", "species_29358", "Q19253", "WBGene00017298", "P58798", "WBGene00000204", "A0A3P6PCS5", "WBGene00000201", "Q9N4I0", "WBGene00000199", "Q8WTM6", "WBGene00021170", "P53489", "WBGene00000200", "Q9XWV3", "WBGene00000203", "O61861", "WBGene00000205", "P91167", "WBGene00016729", "species_1806234", "Q21004", "WBGene00010272", "Q9XUS7", "WBGene00010663", "Q9TXS0", "WBGene00018974", "A0A486WXP9", "WBGene00001043", "Q6AHQ8", "WBGene00018467", "Q9N489", "WBGene00022453", "Q8I4E2", "WBGene00003086", "A0A0K3AS36", "Y116A8C.36d", "P39055", "WBGene00001130", "O17590", "WBGene00007620", "G5ECL2", "WBGene00006763" ] }, "reaction_10567115": { "compartment": "compartment_876", "id": "reaction_10567115", "reactome": "R-CEL-8871196", "name": "Initial binding of AP-2 and clathrin to PI(4,5)P2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10548814", "species_10522246", "species_179856" ], "products": [ "species_10565751" ], "modifiers": [], "additional_components": [ "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "species_179856", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "P35603", "WBGene00001082", "Q19123", "WBGene00000157" ] }, "reaction_10566475": { "compartment": "compartment_876", "id": "reaction_10566475", "reactome": "R-CEL-8868066", "name": "PIP5K1C phosphorylates PI(4)P to PI(4,5)P2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_392417" ], "products": [ "species_29370", "species_179856" ], "modifiers": [ [ "species_10521254", "catalyst" ] ], "additional_components": [ "WBGene00004087" ] }, "reaction_10566666": { "compartment": "compartment_24339", "id": "reaction_10566666", "reactome": "R-CEL-8868658", "name": "HSPA8-mediated ATP hydrolysis promotes vesicle uncoating", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10566659" ], "products": [ "species_29372", "species_10566663", "species_10566661" ], "modifiers": [ [ "species_10566659", "catalyst" ] ], "additional_components": [ "Q02328", "WBGene00022717", "G5ECQ3", "WBGene00004762", "Q20483", "WBGene00018516", "Q19253", "WBGene00017298", "P58798", "WBGene00000204", "A0A3P6PCS5", "WBGene00000201", "Q9N4I0", "WBGene00000199", "species_29358", "Q8WTM6", "WBGene00021170", "P53489", "WBGene00000200", "Q9XWV3", "WBGene00000203", "O61861", "WBGene00000205", "P91167", "WBGene00016729", "Q9XUS7", "WBGene00010663", "B1V8A0", "WBGene00006791", "Q9TXS0", "WBGene00018974", "Q9N489", "WBGene00022453", "A0A0K3AS36", "Y116A8C.36d", "P39055", "WBGene00001130", "species_29420", "O17590", "WBGene00007620", "G5ECL2", "WBGene00006763", "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q9XTT3", 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"A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "Q9U7D5", "WBGene00001519", "P51485", "WBGene00000195", "P90761", "WBGene00006777", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "P0DM42", "WBGene00000065", "P10984", "WBGene00000064", "P10986", "WBGene00000066", "P0DM41", "WBGene00000063", "species_1806234", "Q21004", "WBGene00010272", "P09446", "WBGene00002005", "A0A486WXP9", "WBGene00001043", "Q6AHQ8", "WBGene00018467", "Q8I4E2", "WBGene00003086" ] }, "reaction_10566477": { "compartment": "compartment_876", "id": "reaction_10566477", "reactome": "R-CEL-8868071", "name": "Clathrin recruits PIK3C2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10537176", "species_10566401" ], "products": [ "species_10566403" ], "modifiers": [], "additional_components": [ "WBGene00009552", "G5ECQ3", "WBGene00004762", "Q20483", "WBGene00018516", "Q9BIF4", "WBGene00001224", "species_179856", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "Q9TXS0", "WBGene00018974", "Q9N489", "WBGene00022453", "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "Q19123", "WBGene00000157", "P35603", "WBGene00001082", "A0A0K3AS36", "Y116A8C.36d", "Q95XH1", "WBGene00022077", "G5EBK2", "WBGene00014084", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q19767", "WBGene00004898", "Q94057", "WBGene00044062", "Q9XZI6", "WBGene00006751", "Q9N532", "WBGene00003238", "G5EDV1", "WBGene00003006", "P34889", "WBGene00000858", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "Q9U7D5", "WBGene00001519", "P51485", "WBGene00000195", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "P90761", "WBGene00006777", "Q18453", "WBGene00004682", "Q9BI71", "WBGene00001329", "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "B1V8A0", "WBGene00006791", "P29355", "WBGene00004774", "Q17796", "WBGene00004101", "O01498", "WBGene00004109", "Q21496", "WBGene00020010", "Q21948", "WBGene00020010", "A0A486WXX8", "WBGene00000894", "Q95QV2", "WBGene00000477", "Q19625", "WBGene00003412", "P34711", "WBGene00006756", "Q9XTT3", "WBGene00013039", "G5ECQ3", "WBGene00004762", "Q20483", "WBGene00018516", "Q9BIF4", "WBGene00001224", "species_179856", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "Q9TXS0", "WBGene00018974", "Q9N489", "WBGene00022453", "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "Q19123", "WBGene00000157", "P35603", "WBGene00001082", "A0A0K3AS36", "Y116A8C.36d", "Q95XH1", "WBGene00022077", "G5EBK2", "WBGene00014084", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q19767", "WBGene00004898", "Q94057", "WBGene00044062", "Q9XZI6", "WBGene00006751", "Q9N532", "WBGene00003238", "G5EDV1", "WBGene00003006", "P34889", "WBGene00000858", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "Q9U7D5", "WBGene00001519", "P51485", "WBGene00000195", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "P90761", "WBGene00006777", "Q18453", "WBGene00004682", "Q9BI71", "WBGene00001329", "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "B1V8A0", "WBGene00006791", "P29355", "WBGene00004774", "Q17796", "WBGene00004101", "O01498", "WBGene00004109", "Q21496", "WBGene00020010", "Q21948", "WBGene00020010", "A0A486WXX8", "WBGene00000894", "Q95QV2", "WBGene00000477", "Q19625", "WBGene00003412", "P34711", "WBGene00006756", "Q9XTT3", "WBGene00013039", "G5EDY0", "WBGene00009552" ] }, "reaction_10566508": { "compartment": "compartment_876", "id": "reaction_10566508", "reactome": "R-CEL-8868236", "name": "BAR domain proteins recruit dynamin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10566504", "species_10566502" ], "products": [ "species_10566506" ], "modifiers": [], "additional_components": [ "P39055", "WBGene00001130", "species_29438", "Q02328", "WBGene00022717", "P0DM42", "WBGene00000065", "P10984", "WBGene00000064", "P10986", "WBGene00000066", "P0DM41", "WBGene00000063", "species_29358", "P58798", "WBGene00000204", "A0A3P6PCS5", "WBGene00000201", "Q9N4I0", "WBGene00000199", "Q8WTM6", "WBGene00021170", "P53489", "WBGene00000200", "Q9XWV3", "WBGene00000203", "O61861", "WBGene00000205", "P91167", "WBGene00016729", "Q19253", "WBGene00017298", "Q9XUS7", "WBGene00010663", "B1V8A0", "WBGene00006791", "Q21004", "WBGene00010272", "Q9BIF4", "WBGene00001224", "G5ECQ3", "WBGene00004762", "Q20483", "WBGene00018516", "species_179856", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "Q9TXS0", "WBGene00018974", "Q9N489", "WBGene00022453", "Q95XH1", "WBGene00022077", "G5EBK2", "WBGene00014084", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q19767", "WBGene00004898", "Q94057", "WBGene00044062", "Q9XZI6", "WBGene00006751", "Q9N532", "WBGene00003238", "G5EDV1", "WBGene00003006", "P34889", "WBGene00000858", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "Q9U7D5", "WBGene00001519", "P51485", "WBGene00000195", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "P90761", "WBGene00006777", "Q18453", "WBGene00004682", "Q9BI71", "WBGene00001329", "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "P29355", "WBGene00004774", "Q17796", "WBGene00004101", "O01498", "WBGene00004109", "Q21496", "WBGene00020010", "Q21948", "WBGene00020010", "A0A486WXX8", "WBGene00000894", "Q95QV2", "WBGene00000477", "Q19625", "WBGene00003412", "P34711", "WBGene00006756", "Q9XTT3", "WBGene00013039", "A0A0K3AS36", "Y116A8C.36d", "Q6AHQ8", "WBGene00018467", "Q8I4E2", "WBGene00003086", "Q02328", "WBGene00022717", "P0DM42", "WBGene00000065", "P10984", "WBGene00000064", "P10986", "WBGene00000066", "P0DM41", "WBGene00000063", "species_29358", "P58798", "WBGene00000204", "A0A3P6PCS5", "WBGene00000201", "Q9N4I0", "WBGene00000199", "Q8WTM6", "WBGene00021170", "P53489", "WBGene00000200", "Q9XWV3", "WBGene00000203", "O61861", "WBGene00000205", "P91167", "WBGene00016729", "Q19253", "WBGene00017298", "Q9XUS7", "WBGene00010663", "B1V8A0", "WBGene00006791", "Q21004", "WBGene00010272", "Q9BIF4", "WBGene00001224", "G5ECQ3", "WBGene00004762", "Q20483", "WBGene00018516", "species_179856", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "Q9TXS0", "WBGene00018974", "Q9N489", "WBGene00022453", "Q95XH1", "WBGene00022077", "G5EBK2", "WBGene00014084", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q19767", "WBGene00004898", "Q94057", "WBGene00044062", "Q9XZI6", "WBGene00006751", "Q9N532", "WBGene00003238", "G5EDV1", "WBGene00003006", "P34889", "WBGene00000858", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "Q9U7D5", "WBGene00001519", "P51485", "WBGene00000195", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "P90761", "WBGene00006777", "Q18453", "WBGene00004682", "Q9BI71", "WBGene00001329", "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "P29355", "WBGene00004774", "Q17796", "WBGene00004101", "O01498", "WBGene00004109", "Q21496", "WBGene00020010", "Q21948", "WBGene00020010", "A0A486WXX8", "WBGene00000894", "Q95QV2", "WBGene00000477", "Q19625", "WBGene00003412", "P34711", "WBGene00006756", "Q9XTT3", "WBGene00013039", "A0A0K3AS36", "Y116A8C.36d", "Q6AHQ8", "WBGene00018467", "Q8I4E2", "WBGene00003086", "P39055", "WBGene00001130", "species_29438" ] }, "reaction_10566480": { "compartment": "compartment_876", "id": "reaction_10566480", "reactome": "R-CEL-8868072", "name": "Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_392417" ], "products": [ "species_29370", "species_202247" ], "modifiers": [ [ "species_10566403", "catalyst" ] ], "additional_components": [ "G5ECQ3", "WBGene00004762", "Q20483", "WBGene00018516", "Q9BIF4", "WBGene00001224", "species_179856", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "Q9TXS0", "WBGene00018974", "Q9N489", "WBGene00022453", "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "Q19123", "WBGene00000157", "P35603", "WBGene00001082", "A0A0K3AS36", "Y116A8C.36d", "Q95XH1", "WBGene00022077", "G5EBK2", "WBGene00014084", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q19767", "WBGene00004898", "Q94057", "WBGene00044062", "Q9XZI6", "WBGene00006751", "Q9N532", "WBGene00003238", "G5EDV1", "WBGene00003006", "P34889", "WBGene00000858", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "Q9U7D5", "WBGene00001519", "P51485", "WBGene00000195", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "P90761", "WBGene00006777", "Q18453", "WBGene00004682", "Q9BI71", "WBGene00001329", "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "B1V8A0", "WBGene00006791", "P29355", "WBGene00004774", "Q17796", "WBGene00004101", "O01498", "WBGene00004109", "Q21496", "WBGene00020010", "Q21948", "WBGene00020010", "A0A486WXX8", "WBGene00000894", "Q95QV2", "WBGene00000477", "Q19625", "WBGene00003412", "P34711", "WBGene00006756", "Q9XTT3", "WBGene00013039", "G5EDY0", "WBGene00009552" ] }, "reaction_10566672": { "compartment": "compartment_24339", "id": "reaction_10566672", "reactome": "R-CEL-8868659", "name": "Clathrin recruits auxilins to the clathrin-coated vesicle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10566668", "species_10522393" ], "products": [ "species_10566670" ], "modifiers": [], "additional_components": [ "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q9XTT3", "WBGene00013039", "Q19625", "WBGene00003412", "Q95QV2", "WBGene00000477", "P34711", "WBGene00006756", "Q21496", "WBGene00020010", "Q21948", "WBGene00020010", "A0A486WXX8", "WBGene00000894", "O02495", "WBGene00004897", "G5EBK2", "WBGene00014084", "P34351", "WBGene00004899", "Q19767", "WBGene00004898", "Q94057", "WBGene00044062", "Q95XH1", "WBGene00022077", "Q9XZI6", "WBGene00006751", "Q9BIF4", "WBGene00001224", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "B1V8A0", "WBGene00006791", "Q18453", "WBGene00004682", "Q9BI71", "WBGene00001329", "P29355", "WBGene00004774", "Q17796", "WBGene00004101", "O01498", "WBGene00004109", "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "P34889", "WBGene00000858", "G5EDV1", "WBGene00003006", "Q9N532", "WBGene00003238", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "Q9U7D5", "WBGene00001519", "P51485", "WBGene00000195", "P90761", "WBGene00006777", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "Q02328", "WBGene00022717", "G5ECQ3", "WBGene00004762", "Q20483", "WBGene00018516", "P0DM42", "WBGene00000065", "P10984", "WBGene00000064", "P10986", "WBGene00000066", "P0DM41", "WBGene00000063", "species_29358", "Q19253", "WBGene00017298", "P58798", "WBGene00000204", "A0A3P6PCS5", "WBGene00000201", "Q9N4I0", "WBGene00000199", "Q8WTM6", "WBGene00021170", "P53489", "WBGene00000200", "Q9XWV3", "WBGene00000203", "O61861", "WBGene00000205", "P91167", "WBGene00016729", "species_1806234", "Q21004", "WBGene00010272", "Q9XUS7", "WBGene00010663", "Q9TXS0", "WBGene00018974", "Q6AHQ8", "WBGene00018467", "Q9N489", "WBGene00022453", "Q8I4E2", "WBGene00003086", "A0A0K3AS36", "Y116A8C.36d", "P39055", "WBGene00001130", "species_29420", "O17590", "WBGene00007620", "G5ECL2", "WBGene00006763", "WBGene00001043", "Q02328", "WBGene00022717", "G5ECQ3", "WBGene00004762", "Q20483", "WBGene00018516", "Q19253", "WBGene00017298", "P58798", "WBGene00000204", "A0A3P6PCS5", "WBGene00000201", "Q9N4I0", "WBGene00000199", "species_29358", "Q8WTM6", "WBGene00021170", "P53489", "WBGene00000200", "Q9XWV3", "WBGene00000203", "O61861", "WBGene00000205", "P91167", "WBGene00016729", "Q9XUS7", "WBGene00010663", "B1V8A0", "WBGene00006791", "Q9TXS0", "WBGene00018974", "Q9N489", "WBGene00022453", "A0A0K3AS36", "Y116A8C.36d", "P39055", "WBGene00001130", "species_29420", "O17590", "WBGene00007620", "G5ECL2", "WBGene00006763", "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q9XTT3", "WBGene00013039", "Q19625", "WBGene00003412", "Q95QV2", "WBGene00000477", "P34711", "WBGene00006756", "Q21496", "WBGene00020010", "Q21948", "WBGene00020010", "A0A486WXX8", "WBGene00000894", "O02495", "WBGene00004897", "G5EBK2", "WBGene00014084", "P34351", "WBGene00004899", "Q19767", "WBGene00004898", "Q94057", "WBGene00044062", "Q95XH1", "WBGene00022077", "Q9XZI6", "WBGene00006751", "Q9BIF4", "WBGene00001224", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "Q18453", "WBGene00004682", "Q9BI71", "WBGene00001329", "P29355", "WBGene00004774", "Q17796", "WBGene00004101", "O01498", "WBGene00004109", "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "P34889", "WBGene00000858", "G5EDV1", "WBGene00003006", "Q9N532", "WBGene00003238", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "Q9U7D5", "WBGene00001519", "P51485", "WBGene00000195", "P90761", "WBGene00006777", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "P0DM42", "WBGene00000065", "P10984", "WBGene00000064", "P10986", "WBGene00000066", "P0DM41", "WBGene00000063", "species_1806234", "Q21004", "WBGene00010272", "A0A486WXP9", "WBGene00001043", "Q6AHQ8", "WBGene00018467", "Q8I4E2", "WBGene00003086" ] }, "reaction_10566674": { "compartment": "compartment_24339", "id": "reaction_10566674", "reactome": "R-CEL-8868660", "name": "Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10565761" ], "products": [ "species_29370", "species_10565777" ], "modifiers": [ [ "species_10565761", "catalyst" ] ], "additional_components": [ "G5ECQ3", "WBGene00004762", "Q20483", "WBGene00018516", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "Q9BIF4", "WBGene00001224", "species_179856", "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q9TXS0", "WBGene00018974", "A0A0K3AS36", "Y116A8C.36d", "Q9N489", "WBGene00022453", "G5ECQ3", "WBGene00004762", "Q20483", "WBGene00018516", "Q9BIF4", "WBGene00001224", "species_179856", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "Q9TXS0", "WBGene00018974", "Q9N489", "WBGene00022453", "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "Q19123", "WBGene00000157", "P35603", "WBGene00001082", "A0A0K3AS36", "Y116A8C.36d", "G5ECQ3", "WBGene00004762", "Q20483", "WBGene00018516", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "Q9BIF4", "WBGene00001224", "species_179856", "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "Q9TXS0", "WBGene00018974", "A0A0K3AS36", "Y116A8C.36d", "Q9N489", "WBGene00022453" ] }, "reaction_10566523": { "compartment": "compartment_876", "id": "reaction_10566523", "reactome": "R-CEL-8868648", "name": "SYNJ hydrolyze PI(4,5)P2 to PI(4)P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10566518" ], "products": [ "species_29372", "species_10566520" ], "modifiers": [ [ "species_10566518", "catalyst" ] ], "additional_components": [ "Q02328", "WBGene00022717", "P0DM42", "WBGene00000065", "P10984", "WBGene00000064", "P10986", "WBGene00000066", "P0DM41", "WBGene00000063", "species_29358", "P58798", "WBGene00000204", "A0A3P6PCS5", "WBGene00000201", "Q9N4I0", "WBGene00000199", "Q8WTM6", "WBGene00021170", "P53489", "WBGene00000200", "Q9XWV3", "WBGene00000203", "O61861", "WBGene00000205", "P91167", "WBGene00016729", "Q19253", "WBGene00017298", "Q9XUS7", "WBGene00010663", "B1V8A0", "WBGene00006791", "Q21004", "WBGene00010272", "Q9BIF4", "WBGene00001224", "G5ECQ3", "WBGene00004762", "Q20483", "WBGene00018516", "species_179856", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "Q9TXS0", "WBGene00018974", "Q9N489", "WBGene00022453", "Q95XH1", "WBGene00022077", 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10537150", "species_10566506" ], "products": [ "species_10566518" ], "modifiers": [], "additional_components": [ "O17590", "WBGene00007620", "G5ECL2", "WBGene00006763", "Q02328", "WBGene00022717", "P0DM42", "WBGene00000065", "P10984", "WBGene00000064", "P10986", "WBGene00000066", "P0DM41", "WBGene00000063", "species_29358", "P58798", "WBGene00000204", "A0A3P6PCS5", "WBGene00000201", "Q9N4I0", "WBGene00000199", "Q8WTM6", "WBGene00021170", "P53489", "WBGene00000200", "Q9XWV3", "WBGene00000203", "O61861", "WBGene00000205", "P91167", "WBGene00016729", "Q19253", "WBGene00017298", "Q9XUS7", "WBGene00010663", "B1V8A0", "WBGene00006791", "Q21004", "WBGene00010272", "Q9BIF4", "WBGene00001224", "G5ECQ3", "WBGene00004762", "Q20483", "WBGene00018516", "species_179856", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "Q9TXS0", "WBGene00018974", "Q9N489", "WBGene00022453", "Q95XH1", "WBGene00022077", "G5EBK2", "WBGene00014084", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q19767", "WBGene00004898", "Q94057", "WBGene00044062", "Q9XZI6", "WBGene00006751", "Q9N532", "WBGene00003238", "G5EDV1", "WBGene00003006", "P34889", "WBGene00000858", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "Q9U7D5", "WBGene00001519", "P51485", "WBGene00000195", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "P90761", "WBGene00006777", "Q18453", "WBGene00004682", "Q9BI71", "WBGene00001329", "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "P29355", "WBGene00004774", "Q17796", "WBGene00004101", "O01498", "WBGene00004109", "Q21496", "WBGene00020010", "Q21948", "WBGene00020010", "A0A486WXX8", "WBGene00000894", "Q95QV2", "WBGene00000477", "Q19625", "WBGene00003412", "P34711", "WBGene00006756", "Q9XTT3", "WBGene00013039", "A0A0K3AS36", "Y116A8C.36d", "Q6AHQ8", "WBGene00018467", "Q8I4E2", "WBGene00003086", "P39055", "WBGene00001130", "species_29438", "Q02328", "WBGene00022717", "P0DM42", "WBGene00000065", "P10984", "WBGene00000064", "P10986", "WBGene00000066", "P0DM41", "WBGene00000063", "species_29358", "P58798", "WBGene00000204", "A0A3P6PCS5", "WBGene00000201", "Q9N4I0", "WBGene00000199", "Q8WTM6", "WBGene00021170", "P53489", "WBGene00000200", "Q9XWV3", "WBGene00000203", "O61861", "WBGene00000205", "P91167", "WBGene00016729", "Q19253", "WBGene00017298", "Q9XUS7", "WBGene00010663", "B1V8A0", "WBGene00006791", "Q21004", "WBGene00010272", "Q9BIF4", "WBGene00001224", "G5ECQ3", "WBGene00004762", "Q20483", "WBGene00018516", "species_179856", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "Q9TXS0", "WBGene00018974", "Q9N489", "WBGene00022453", "Q95XH1", "WBGene00022077", "G5EBK2", "WBGene00014084", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q19767", "WBGene00004898", "Q94057", "WBGene00044062", "Q9XZI6", "WBGene00006751", "Q9N532", "WBGene00003238", "G5EDV1", "WBGene00003006", "P34889", "WBGene00000858", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "Q9U7D5", "WBGene00001519", "P51485", "WBGene00000195", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "P90761", "WBGene00006777", "Q18453", "WBGene00004682", "Q9BI71", "WBGene00001329", "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "P29355", "WBGene00004774", "Q17796", "WBGene00004101", "O01498", "WBGene00004109", "Q21496", "WBGene00020010", "Q21948", "WBGene00020010", "A0A486WXX8", "WBGene00000894", "Q95QV2", "WBGene00000477", "Q19625", "WBGene00003412", "P34711", "WBGene00006756", "Q9XTT3", "WBGene00013039", "A0A0K3AS36", "Y116A8C.36d", "Q6AHQ8", "WBGene00018467", "Q8I4E2", "WBGene00003086", "P39055", "WBGene00001130", "species_29438", "O17590", "WBGene00007620", "G5ECL2", "WBGene00006763" ] }, "reaction_10566462": { "compartment": "compartment_876", "id": "reaction_10566462", "reactome": "R-CEL-8867754", "name": "F- and N- BAR domain proteins bind the clathrin-coated pit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10566428", "species_10566426", "species_10566456", "species_10566409", "species_10566437", "species_10512243", "species_10566403", "species_10566448" ], "products": [ "species_10565743", "species_10566460", "species_10537176" ], "modifiers": [ [ "species_202247", "catalyst" ] ], "additional_components": [ "WBGene00003086", "Q6AHQ8", "WBGene00018467", "Q19253", "WBGene00017298", "Q9XUS7", "WBGene00010663", "Q21004", "WBGene00010272", "Q19253", "WBGene00017298", "B1V8A0", "WBGene00006791", "G5ECQ3", "WBGene00004762", "Q20483", "WBGene00018516", "Q9BIF4", "WBGene00001224", "species_179856", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "Q9TXS0", "WBGene00018974", "Q9N489", "WBGene00022453", "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "Q19123", "WBGene00000157", "P35603", "WBGene00001082", "A0A0K3AS36", "Y116A8C.36d", "Q95XH1", "WBGene00022077", "G5EBK2", "WBGene00014084", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q19767", "WBGene00004898", "Q94057", "WBGene00044062", "Q9XZI6", "WBGene00006751", "Q9N532", "WBGene00003238", "G5EDV1", "WBGene00003006", "P34889", "WBGene00000858", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "Q9U7D5", "WBGene00001519", "P51485", "WBGene00000195", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "P90761", "WBGene00006777", "Q18453", "WBGene00004682", "Q9BI71", "WBGene00001329", "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "B1V8A0", "WBGene00006791", "P29355", "WBGene00004774", "Q17796", "WBGene00004101", "O01498", "WBGene00004109", "Q21496", "WBGene00020010", "Q21948", "WBGene00020010", "A0A486WXX8", "WBGene00000894", "Q95QV2", "WBGene00000477", "Q19625", "WBGene00003412", "P34711", "WBGene00006756", "Q9XTT3", "WBGene00013039", "G5EDY0", "WBGene00009552", "Q19253", "WBGene00017298", "Q9XUS7", "WBGene00010663", "Q9TXS0", "WBGene00018974", "Q19253", "WBGene00017298", "Q9XUS7", "WBGene00010663", "B1V8A0", "WBGene00006791", "Q21004", "WBGene00010272", "Q9BIF4", "WBGene00001224", "G5ECQ3", "WBGene00004762", "Q20483", "WBGene00018516", "species_179856", "P34574", "WBGene00011867", "P90961", "WBGene00020246", "Q9TXS0", "WBGene00018974", "Q9N489", "WBGene00022453", "Q95XH1", "WBGene00022077", "G5EBK2", "WBGene00014084", "O02495", "WBGene00004897", "P34351", "WBGene00004899", "Q19767", "WBGene00004898", "Q94057", "WBGene00044062", "Q9XZI6", "WBGene00006751", "Q9N532", "WBGene00003238", "G5EDV1", "WBGene00003006", "P34889", "WBGene00000858", "A0A0K3AUI8", "C34F11.9e", "Q18239", "WBGene00001102", "Q22227", "WBGene00003241", "Q9U7D5", "WBGene00001519", "P51485", "WBGene00000195", "Q19136", "WBGene00006306", "Q23056", "WBGene00020861", "Q965S5", "WBGene00004923", "K8FE10", "WBGene00004922", "O16700", "WBGene00004925", "P34693", "WBGene00004921", "P90761", "WBGene00006777", "Q18453", "WBGene00004682", "Q9BI71", "WBGene00001329", "Q19019", "WBGene00004829", "P24348", "WBGene00002299", "Q22601", "WBGene00000161", "Q9N4F3", "WBGene00000160", "P35603", "WBGene00001082", "Q19123", "WBGene00000157", "P29355", "WBGene00004774", "Q17796", "WBGene00004101", "O01498", "WBGene00004109", "Q21496", "WBGene00020010", "Q21948", "WBGene00020010", "A0A486WXX8", "WBGene00000894", "Q95QV2", "WBGene00000477", "Q19625", "WBGene00003412", "P34711", "WBGene00006756", "Q9XTT3", "WBGene00013039", "A0A0K3AS36", "Y116A8C.36d", "Q6AHQ8", "WBGene00018467", "Q8I4E2", "WBGene00003086", "WBGene00009552" ] }, "reaction_10552405": { "compartment": "compartment_70101", "id": "reaction_10552405", "reactome": "R-CEL-5577213", "name": "LTCC multimer transports Ca2+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74112" ], "products": [ "species_74016" ], "modifiers": [ [ "species_10552402", "catalyst" ] ], "additional_components": [ "G5EG74", "WBGene00007041", "P34374", "WBGene00006772", "G5EBI8", "WBGene00017400", "G5EDT2", "WBGene00007670", "Q8MQA1", "WBGene00001187", "A0A078BQJ0", "WBGene00021125", "O01661", "WBGene00000368" ] }, "reaction_10552761": { "compartment": "compartment_70101", "id": "reaction_10552761", "reactome": "R-CEL-5617179", "name": "PRKACA phosphorylates TNNI3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10552741" ], "products": [ "species_29370", "species_10552759" ], "modifiers": [ [ "species_10508954", "catalyst" ] ], "additional_components": [ "Q9XUN9", "WBGene00006585", "O44572", "WBGene00006586", "Q20334", "WBGene00006584", "Q9GYF1", "WBGene00006764", "Q9GYF1", "WBGene00006764", "Q9XUN9", "WBGene00006585", "O44572", "WBGene00006586", "Q20334", "WBGene00006584", "WBGene00002189" ] }, "reaction_10524944": { "compartment": "compartment_70101", "id": "reaction_10524944", "reactome": "R-CEL-445700", "name": "Myosin Binds ATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10524942", "species_113592" ], "products": [ "species_10524933" ], "modifiers": [], "additional_components": [ "Q20641", "WBGene00003776", "Q8I7M7", "WBGene00006582", "O01479", "WBGene00006823", "P0DM41", "WBGene00000063", "P0DM42", "WBGene00000065", "P10984", "WBGene00000064", "P10986", "WBGene00000066", "species_74016", "Q22866", "WBGene00002978", "P19625", "WBGene00003369", "P19626", "WBGene00003370", "Q09510", "WBGene00003372", "Q20238", "WBGene00009585", "Q21201", "WBGene00010554", "Q69Z12", "WBGene00023451", "Q9XVI9", "WBGene00011734", "P53014", "WBGene00003371", "G5EGK1", "WBGene00006771", "P19826", "WBGene00000942", "G5EC32", "WBGene00012891", "P34446", "WBGene00003929", "Q20641", "WBGene00003776", "species_29358", "P19625", "WBGene00003369", "P19626", "WBGene00003370", "Q09510", "WBGene00003372", "Q20238", "WBGene00009585", "Q21201", "WBGene00010554", "Q69Z12", "WBGene00023451", "Q9XVI9", "WBGene00011734", "P53014", "WBGene00003371", "Q8I7M7", "WBGene00006582", "O01479", "WBGene00006823", "P0DM41", "WBGene00000063", "P0DM42", "WBGene00000065", "P10984", "WBGene00000064", "P10986", "WBGene00000066", "species_74016", "Q22866", "WBGene00002978", "G5EGK1", "WBGene00006771", "P19826", "WBGene00000942", "G5EC32", "WBGene00012891", "P34446", "WBGene00003929" ] }, "reaction_10524948": { "compartment": "compartment_70101", "id": "reaction_10524948", "reactome": "R-CEL-445704", "name": "Calcium Binds Caldesmon", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10524946", "species_74016" ], "products": [ "species_10524942" ], "modifiers": [], "additional_components": [ "Q20641", "WBGene00003776", "Q8I7M7", "WBGene00006582", "O01479", "WBGene00006823", "P0DM41", "WBGene00000063", "P0DM42", "WBGene00000065", "P10984", "WBGene00000064", "P10986", "WBGene00000066", "Q22866", "WBGene00002978", "P19625", "WBGene00003369", "P19626", "WBGene00003370", "Q09510", "WBGene00003372", "Q20238", "WBGene00009585", "Q21201", "WBGene00010554", "Q69Z12", "WBGene00023451", "Q9XVI9", "WBGene00011734", "P53014", "WBGene00003371", "G5EGK1", "WBGene00006771", "P19826", "WBGene00000942", "G5EC32", "WBGene00012891", "P34446", "WBGene00003929", "Q20641", "WBGene00003776", "Q8I7M7", "WBGene00006582", "O01479", "WBGene00006823", "P0DM41", "WBGene00000063", "P0DM42", "WBGene00000065", "P10984", "WBGene00000064", "P10986", "WBGene00000066", "species_74016", "Q22866", "WBGene00002978", "P19625", "WBGene00003369", "P19626", "WBGene00003370", "Q09510", "WBGene00003372", "Q20238", "WBGene00009585", "Q21201", "WBGene00010554", "Q69Z12", "WBGene00023451", "Q9XVI9", "WBGene00011734", "P53014", "WBGene00003371", "G5EGK1", "WBGene00006771", "P19826", "WBGene00000942", "G5EC32", "WBGene00012891", "P34446", "WBGene00003929" ] }, "reaction_10524950": { "compartment": "compartment_70101", "id": "reaction_10524950", "reactome": "R-CEL-445705", "name": "Release Of ADP From Myosin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10524937" ], "products": [ "species_10524942", "species_29370" ], "modifiers": [], "additional_components": [ "Q8I7M7", "WBGene00006582", "O01479", "WBGene00006823", "P0DM41", "WBGene00000063", "P0DM42", "WBGene00000065", "P10984", "WBGene00000064", "P10986", "WBGene00000066", "species_74016", "Q20641", "WBGene00003776", "species_113582", "P19625", "WBGene00003369", "P19626", "WBGene00003370", "Q09510", "WBGene00003372", "Q20238", "WBGene00009585", "Q21201", "WBGene00010554", "Q69Z12", "WBGene00023451", "Q9XVI9", "WBGene00011734", "P53014", "WBGene00003371", "Q22866", "WBGene00002978", "G5EGK1", "WBGene00006771", "P19826", "WBGene00000942", "G5EC32", "WBGene00012891", "P34446", "WBGene00003929", "Q20641", "WBGene00003776", "Q8I7M7", "WBGene00006582", "O01479", "WBGene00006823", "P0DM41", "WBGene00000063", "P0DM42", "WBGene00000065", "P10984", "WBGene00000064", "P10986", "WBGene00000066", "species_74016", "Q22866", "WBGene00002978", "P19625", "WBGene00003369", "P19626", "WBGene00003370", "Q09510", "WBGene00003372", "Q20238", "WBGene00009585", "Q21201", "WBGene00010554", "Q69Z12", "WBGene00023451", "Q9XVI9", "WBGene00011734", "P53014", "WBGene00003371", "G5EGK1", "WBGene00006771", "P19826", "WBGene00000942", "G5EC32", "WBGene00012891", "P34446", "WBGene00003929" ] }, "reaction_10524940": { "compartment": "compartment_70101", "id": "reaction_10524940", "reactome": "R-CEL-445699", "name": "ATP Hydrolysis By Myosin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10524933" ], "products": [ "species_29372", "species_10524937" ], "modifiers": [ [ "species_10524866", "catalyst" ] ], "additional_components": [ "Q20641", "WBGene00003776", "species_29358", "P19625", "WBGene00003369", "P19626", "WBGene00003370", "Q09510", "WBGene00003372", "Q20238", "WBGene00009585", "Q21201", "WBGene00010554", "Q69Z12", "WBGene00023451", "Q9XVI9", "WBGene00011734", "P53014", "WBGene00003371", "Q8I7M7", "WBGene00006582", "O01479", "WBGene00006823", "P0DM41", "WBGene00000063", "P0DM42", "WBGene00000065", "P10984", "WBGene00000064", "P10986", "WBGene00000066", "species_74016", "Q22866", "WBGene00002978", "G5EGK1", "WBGene00006771", "P19826", "WBGene00000942", "G5EC32", "WBGene00012891", "P34446", "WBGene00003929", "Q8I7M7", "WBGene00006582", "O01479", "WBGene00006823", "P0DM41", "WBGene00000063", "P0DM42", "WBGene00000065", "P10984", "WBGene00000064", "P10986", "WBGene00000066", "species_74016", "Q20641", "WBGene00003776", "species_113582", "P19625", "WBGene00003369", "P19626", "WBGene00003370", "Q09510", "WBGene00003372", "Q20238", "WBGene00009585", "Q21201", "WBGene00010554", "Q69Z12", "WBGene00023451", "Q9XVI9", "WBGene00011734", "P53014", "WBGene00003371", "Q22866", "WBGene00002978", "G5EGK1", "WBGene00006771", "P19826", "WBGene00000942", "G5EC32", "WBGene00012891", "P34446", "WBGene00003929", "Q20641", "WBGene00003776", "species_29358", "P19625", "WBGene00003369", "P19626", "WBGene00003370", "Q09510", "WBGene00003372", "Q20238", "WBGene00009585", "Q21201", "WBGene00010554", "Q69Z12", "WBGene00023451", "Q9XVI9", "WBGene00011734", "P53014", "WBGene00003371" ] }, "reaction_10551263": { "compartment": "compartment_437051", "id": "reaction_10551263", "reactome": "R-CEL-5263633", "name": "DYSF, CAV3 and TRIM72 bind", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10551259", "species_10551257", "species_10551252" ], "products": [ "species_10551261" ], "modifiers": [ [ "species_74016", "catalyst" ] ], "additional_components": [ "WBGene00021640", "WBGene00001414", "WBGene00000302", "Q18879", "WBGene00000302", "Q17388", "WBGene00001414", "Q9N3T6", "WBGene00021640" ] }, "reaction_10517408": { "compartment": "compartment_984", "id": "reaction_10517408", "reactome": "R-CEL-216058", "name": "Integrin alpha7beta1 binds Laminin-211, 221, 411, 512, 521", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10517404", "species_10517402" ], "products": [ "species_10517406" ], "modifiers": [], "additional_components": [ "Q18823", "WBGene00016913", "O44565", "WBGene00002247", "G5ECE3", "WBGene00002248", "Q21313", "WBGene00001328", "Q27874", "WBGene00003930", "Q03600", "WBGene00002081", "Q27874", "WBGene00003930", "Q03600", "WBGene00002081", "Q18823", "WBGene00016913", "O44565", "WBGene00002247", "G5ECE3", "WBGene00002248", "Q21313", "WBGene00001328" ] }, "reaction_10517382": { "compartment": "compartment_984", "id": "reaction_10517382", "reactome": "R-CEL-216048", "name": "Integrins alpha3beta1, alpha6beta4 bind laminin-332, 511, 521, (211, 221)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10517378", "species_10517313" ], "products": [ "species_10517380" ], "modifiers": [], "additional_components": [ "Q18823", "WBGene00016913", "Q21313", "WBGene00001328", "O44565", "WBGene00002247", "Q19981", "WBGene00006432", "G5EG68", "WBGene00018304", "Q06561", "WBGene00006787", "G5ECE3", "WBGene00002248", "Q03600", "WBGene00002081", "Q27874", "WBGene00003930", "Q03600", "WBGene00002081", "Q27874", "WBGene00003930", "Q18823", "WBGene00016913", "Q21313", "WBGene00001328", "O44565", "WBGene00002247", "Q19981", "WBGene00006432", "G5EG68", "WBGene00018304", "Q06561", "WBGene00006787", "G5ECE3", "WBGene00002248" ] }, "reaction_10548376": { "compartment": "compartment_876", "id": "reaction_10548376", "reactome": "R-CEL-3907292", "name": "Integrin alpha6beta1 binds laminin-322, 512, 521, 211, 221, 411", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10548372", "species_10548370" ], "products": [ "species_10548374" ], "modifiers": [], "additional_components": [ "Q18823", "WBGene00016913", "O44565", "WBGene00002247", "G5ECE3", "WBGene00002248", "Q21313", "WBGene00001328", "Q19981", "WBGene00006432", "G5EG68", "WBGene00018304", "Q06561", "WBGene00006787", "Q27874", "WBGene00003930", "Q03600", "WBGene00002081", "Q27874", "WBGene00003930", "Q03600", "WBGene00002081", "Q18823", "WBGene00016913", "O44565", "WBGene00002247", "G5ECE3", "WBGene00002248", "Q21313", "WBGene00001328", "Q19981", "WBGene00006432", "G5EG68", "WBGene00018304", "Q06561", "WBGene00006787" ] }, "reaction_10517896": { "compartment": "compartment_984", "id": "reaction_10517896", "reactome": "R-CEL-349626", "name": "Integrin alpha2beta1 binds laminin-332", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10517354", "species_10517892" ], "products": [ "species_10517894" ], "modifiers": [], "additional_components": [ "O44565", "WBGene00002247", "Q18823", "WBGene00016913", "Q19981", "WBGene00006432", "G5EG68", "WBGene00018304", "Q06561", "WBGene00006787", "G5ECE3", "WBGene00002248", "Q21313", "WBGene00001328", "P34446", "WBGene00003929", "Q27874", "WBGene00003930", "P34446", "WBGene00003929", "Q27874", "WBGene00003930", "O44565", "WBGene00002247", "Q18823", "WBGene00016913", "Q19981", "WBGene00006432", "G5EG68", "WBGene00018304", "Q06561", "WBGene00006787", "G5ECE3", "WBGene00002248", "Q21313", "WBGene00001328" ] }, "reaction_10548927": { "compartment": "compartment_984", "id": "reaction_10548927", "reactome": "R-CEL-4084507", "name": "Laminin-111 binds endostatin dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10548923", "species_10544249" ], "products": [ "species_10548925" ], "modifiers": [], "additional_components": [ "Q19368", "WBGene00000702", "Q18823", "WBGene00016913", "G5ECE3", "WBGene00002248", "Q21313", "WBGene00001328", "O44565", "WBGene00002247", "Q18823", "WBGene00016913", "G5ECE3", "WBGene00002248", "Q21313", "WBGene00001328", "O44565", "WBGene00002247", "Q19368", "WBGene00000702" ] }, "reaction_10572433": { "compartment": "compartment_17938", "id": "reaction_10572433", "reactome": "R-CEL-9639286", "name": "RRAGC,D exchanges GTP for GDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29420", "species_10572426" ], "products": [ "species_10572430", "species_29438" ], "modifiers": [ [ "species_10572426", "catalyst" ] ], "additional_components": [ "species_29420", "Q22743", "WBGene00006414", "G5EGB3", "WBGene00012497", "species_29438", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "Q9XXU9", "WBGene00006920", "Q22494", "WBGene00020507", "Q23680", "WBGene00006918", "P34462", "WBGene00010130", "Q9XW92", "WBGene00013025", "Q19626", "WBGene00006921", "Q9N5A0", "WBGene00004959", "Q95X44", "WBGene00006917", "P91303", "WBGene00006919", "C0HLB3", "WBGene00006911", "C0HLB4", "WBGene00006912", "Q95YD5", "WBGene00016258", "G5EEK9", "WBGene00006914", "G5EGP4", "WBGene00006915", "P30628", "WBGene00006768", "B2MZD0", "WBGene00006916", "Q20591", "WBGene00009882", "G5EDB8", "WBGene00006913", "species_29420", "Q22743", "WBGene00006414", "G5EGB3", "WBGene00012497", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "Q9XXU9", "WBGene00006920", "Q22494", "WBGene00020507", "Q23680", "WBGene00006918", "P34462", "WBGene00010130", "Q9XW92", "WBGene00013025", "Q19626", "WBGene00006921", "Q9N5A0", "WBGene00004959", "Q95X44", "WBGene00006917", "P91303", "WBGene00006919", "C0HLB3", "WBGene00006911", "C0HLB4", "WBGene00006912", "Q95YD5", "WBGene00016258", "G5EEK9", "WBGene00006914", "G5EGP4", "WBGene00006915", "P30628", "WBGene00006768", "B2MZD0", "WBGene00006916", "Q20591", "WBGene00009882", "G5EDB8", "WBGene00006913", "species_29420", "Q22743", "WBGene00006414", "G5EGB3", "WBGene00012497", "species_29438", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "Q9XXU9", "WBGene00006920", "Q22494", "WBGene00020507", "Q23680", "WBGene00006918", "P34462", "WBGene00010130", "Q9XW92", "WBGene00013025", "Q19626", "WBGene00006921", "Q9N5A0", "WBGene00004959", "Q95X44", "WBGene00006917", "P91303", "WBGene00006919", "C0HLB3", "WBGene00006911", "C0HLB4", "WBGene00006912", "Q95YD5", "WBGene00016258", "G5EEK9", "WBGene00006914", "G5EGP4", "WBGene00006915", "P30628", "WBGene00006768", "B2MZD0", "WBGene00006916", "Q20591", "WBGene00009882", "G5EDB8", "WBGene00006913" ] }, "reaction_10572545": { "compartment": "compartment_17938", "id": "reaction_10572545", "reactome": "R-CEL-9645608", "name": "v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10510526", "species_10572439" ], "products": [ "species_10572450" ], "modifiers": [], "additional_components": [ "P91040", "WBGene00015697", "Q95Q95", "WBGene00002583", "Q68TI8", "WBGene00000911", "species_29420", "G5EGB3", "WBGene00012497", "Q22743", "WBGene00006414", "species_29438", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "Q9XXU9", "WBGene00006920", "Q22494", "WBGene00020507", "Q23680", "WBGene00006918", "P34462", "WBGene00010130", "Q9XW92", "WBGene00013025", "Q19626", "WBGene00006921", "Q9N5A0", "WBGene00004959", "Q95X44", "WBGene00006917", "P91303", "WBGene00006919", "C0HLB3", "WBGene00006911", "C0HLB4", "WBGene00006912", "Q95YD5", "WBGene00016258", "G5EEK9", "WBGene00006914", "G5EGP4", "WBGene00006915", "P30628", "WBGene00006768", "B2MZD0", "WBGene00006916", "Q20591", "WBGene00009882", "G5EDB8", "WBGene00006913", "species_29420", "G5EGB3", "WBGene00012497", "Q22743", "WBGene00006414", "species_29438", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "Q9XXU9", "WBGene00006920", "Q22494", "WBGene00020507", "Q23680", "WBGene00006918", "P34462", "WBGene00010130", "Q9XW92", "WBGene00013025", "Q19626", "WBGene00006921", "Q9N5A0", "WBGene00004959", "Q95X44", "WBGene00006917", "P91303", "WBGene00006919", "C0HLB3", "WBGene00006911", "C0HLB4", "WBGene00006912", "Q95YD5", "WBGene00016258", "G5EEK9", "WBGene00006914", "G5EGP4", "WBGene00006915", "P30628", "WBGene00006768", "B2MZD0", "WBGene00006916", "Q20591", "WBGene00009882", "G5EDB8", "WBGene00006913", "P91040", "WBGene00015697", "Q95Q95", "WBGene00002583", "Q68TI8", "WBGene00000911" ] }, "reaction_10572448": { "compartment": "compartment_17938", "id": "reaction_10572448", "reactome": "R-CEL-9640175", "name": "v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10572430", "species_10572435" ], "products": [ "species_10572437" ], "modifiers": [], "additional_components": [ "species_29420", "Q22743", "WBGene00006414", "G5EGB3", "WBGene00012497", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "Q9XXU9", "WBGene00006920", "Q22494", "WBGene00020507", "Q23680", "WBGene00006918", "P34462", "WBGene00010130", "Q9XW92", "WBGene00013025", "Q19626", "WBGene00006921", "Q9N5A0", "WBGene00004959", "Q95X44", "WBGene00006917", "P91303", "WBGene00006919", "C0HLB3", "WBGene00006911", "C0HLB4", "WBGene00006912", "Q95YD5", "WBGene00016258", "G5EEK9", "WBGene00006914", "G5EGP4", "WBGene00006915", "P30628", "WBGene00006768", "B2MZD0", "WBGene00006916", "Q20591", "WBGene00009882", "G5EDB8", "WBGene00006913", "Q19425", "WBGene00008774", "species_29468", "Q19425", "WBGene00008774", "species_29468", "species_29420", "Q22743", "WBGene00006414", "G5EGB3", "WBGene00012497", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "Q9XXU9", "WBGene00006920", "Q22494", "WBGene00020507", "Q23680", "WBGene00006918", "P34462", "WBGene00010130", "Q9XW92", "WBGene00013025", "Q19626", "WBGene00006921", "Q9N5A0", "WBGene00004959", "Q95X44", "WBGene00006917", "P91303", "WBGene00006919", "C0HLB3", "WBGene00006911", "C0HLB4", "WBGene00006912", "Q95YD5", "WBGene00016258", "G5EEK9", "WBGene00006914", "G5EGP4", "WBGene00006915", "P30628", "WBGene00006768", "B2MZD0", "WBGene00006916", "Q20591", "WBGene00009882", "G5EDB8", "WBGene00006913" ] }, "reaction_10572553": { "compartment": "compartment_17938", "id": "reaction_10572553", "reactome": "R-CEL-9646468", "name": "mTORC1 binds RHEB:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10510507", "species_10572450" ], "products": [ "species_10572452" ], "modifiers": [], "additional_components": [ "P34443", "WBGene00010038", "species_29438", "species_29420", "G5EGB3", "WBGene00012497", "Q22743", "WBGene00006414", "species_29438", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "Q9XXU9", "WBGene00006920", "Q22494", "WBGene00020507", "Q23680", "WBGene00006918", "P34462", "WBGene00010130", "Q9XW92", "WBGene00013025", "Q19626", "WBGene00006921", "Q9N5A0", "WBGene00004959", "Q95X44", "WBGene00006917", "P91303", "WBGene00006919", "C0HLB3", "WBGene00006911", "C0HLB4", "WBGene00006912", "Q95YD5", "WBGene00016258", "G5EEK9", "WBGene00006914", "G5EGP4", "WBGene00006915", "P30628", "WBGene00006768", "B2MZD0", "WBGene00006916", "Q20591", "WBGene00009882", "G5EDB8", "WBGene00006913", "P91040", "WBGene00015697", "Q95Q95", "WBGene00002583", "Q68TI8", "WBGene00000911", "species_29420", "G5EGB3", "WBGene00012497", "Q22743", "WBGene00006414", "species_29438", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "Q9XXU9", "WBGene00006920", "Q22494", "WBGene00020507", "Q23680", "WBGene00006918", "P34462", "WBGene00010130", "Q9XW92", "WBGene00013025", "Q19626", "WBGene00006921", "Q9N5A0", "WBGene00004959", "Q95X44", "WBGene00006917", "P91303", "WBGene00006919", "C0HLB3", "WBGene00006911", "C0HLB4", "WBGene00006912", "Q95YD5", "WBGene00016258", "G5EEK9", "WBGene00006914", "G5EGP4", "WBGene00006915", "P30628", "WBGene00006768", "B2MZD0", "WBGene00006916", "Q20591", "WBGene00009882", "G5EDB8", "WBGene00006913", "P91040", "WBGene00015697", "Q95Q95", "WBGene00002583", "Q68TI8", "WBGene00000911", "P34443", "WBGene00010038" ] }, "reaction_10572457": { "compartment": "compartment_17938", "id": "reaction_10572457", "reactome": "R-CEL-9640195", "name": "RRAGA,B hydrolyzes GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10572452" ], "products": [ "species_29372", "species_10572454" ], "modifiers": [ [ "species_10572452", "catalyst" ] ], "additional_components": [ "species_29420", "G5EGB3", "WBGene00012497", "Q22743", "WBGene00006414", "species_29438", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "Q9XXU9", "WBGene00006920", "Q22494", "WBGene00020507", "Q23680", "WBGene00006918", "P34462", "WBGene00010130", "Q9XW92", "WBGene00013025", "Q19626", "WBGene00006921", "Q9N5A0", "WBGene00004959", "Q95X44", "WBGene00006917", "P91303", "WBGene00006919", "C0HLB3", "WBGene00006911", "C0HLB4", "WBGene00006912", "Q95YD5", "WBGene00016258", "G5EEK9", "WBGene00006914", "G5EGP4", "WBGene00006915", "P30628", "WBGene00006768", "B2MZD0", "WBGene00006916", "Q20591", "WBGene00009882", "G5EDB8", "WBGene00006913", "P91040", "WBGene00015697", "Q95Q95", "WBGene00002583", "Q68TI8", "WBGene00000911", "P34443", "WBGene00010038", "P34443", "WBGene00010038", "species_29438", "P91040", "WBGene00015697", "Q95Q95", "WBGene00002583", "Q68TI8", "WBGene00000911", "species_29420", "Q22743", "WBGene00006414", "G5EGB3", "WBGene00012497", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "Q9XXU9", "WBGene00006920", "Q22494", "WBGene00020507", "Q23680", "WBGene00006918", "P34462", "WBGene00010130", "Q9XW92", "WBGene00013025", "Q19626", "WBGene00006921", "Q9N5A0", "WBGene00004959", "Q95X44", "WBGene00006917", "P91303", "WBGene00006919", "C0HLB3", "WBGene00006911", "C0HLB4", "WBGene00006912", "Q95YD5", "WBGene00016258", "G5EEK9", "WBGene00006914", "G5EGP4", "WBGene00006915", "P30628", "WBGene00006768", "B2MZD0", "WBGene00006916", "Q20591", "WBGene00009882", "G5EDB8", "WBGene00006913", "species_29420", "G5EGB3", "WBGene00012497", "Q22743", "WBGene00006414", "species_29438", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "Q9XXU9", "WBGene00006920", "Q22494", "WBGene00020507", "Q23680", "WBGene00006918", "P34462", "WBGene00010130", "Q9XW92", "WBGene00013025", "Q19626", "WBGene00006921", "Q9N5A0", "WBGene00004959", "Q95X44", "WBGene00006917", "P91303", "WBGene00006919", "C0HLB3", "WBGene00006911", "C0HLB4", "WBGene00006912", "Q95YD5", "WBGene00016258", "G5EEK9", "WBGene00006914", "G5EGP4", "WBGene00006915", "P30628", "WBGene00006768", "B2MZD0", "WBGene00006916", "Q20591", "WBGene00009882", "G5EDB8", "WBGene00006913", "P91040", "WBGene00015697", "Q95Q95", "WBGene00002583", "Q68TI8", "WBGene00000911", "P34443", "WBGene00010038" ] }, "reaction_10572444": { "compartment": "compartment_17938", "id": "reaction_10572444", "reactome": "R-CEL-9640167", "name": "RRAGA,B exchanges GDP for GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10572437" ], "products": [ "species_29420", "species_10572441" ], "modifiers": [ [ "species_10572437", "catalyst" ] ], "additional_components": [ "Q19425", "WBGene00008774", "species_29468", "species_29420", "Q22743", "WBGene00006414", "G5EGB3", "WBGene00012497", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "Q9XXU9", "WBGene00006920", "Q22494", "WBGene00020507", "Q23680", "WBGene00006918", "P34462", "WBGene00010130", "Q9XW92", "WBGene00013025", "Q19626", "WBGene00006921", "Q9N5A0", "WBGene00004959", "Q95X44", "WBGene00006917", "P91303", "WBGene00006919", "C0HLB3", "WBGene00006911", "C0HLB4", "WBGene00006912", "Q95YD5", "WBGene00016258", "G5EEK9", "WBGene00006914", "G5EGP4", "WBGene00006915", "P30628", "WBGene00006768", "B2MZD0", "WBGene00006916", "Q20591", "WBGene00009882", "G5EDB8", "WBGene00006913", "Q19425", "WBGene00008774", "species_29468", "species_29420", "G5EGB3", "WBGene00012497", "Q22743", "WBGene00006414", "species_29438", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "Q9XXU9", "WBGene00006920", "Q22494", "WBGene00020507", "Q23680", "WBGene00006918", "P34462", "WBGene00010130", "Q9XW92", "WBGene00013025", "Q19626", "WBGene00006921", "Q9N5A0", "WBGene00004959", "Q95X44", "WBGene00006917", "P91303", "WBGene00006919", "C0HLB3", "WBGene00006911", "C0HLB4", "WBGene00006912", "Q95YD5", "WBGene00016258", "G5EEK9", "WBGene00006914", "G5EGP4", "WBGene00006915", "P30628", "WBGene00006768", "B2MZD0", "WBGene00006916", "Q20591", "WBGene00009882", "G5EDB8", "WBGene00006913", "Q19425", "WBGene00008774", "species_29468", "species_29420", "Q22743", "WBGene00006414", "G5EGB3", "WBGene00012497", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "Q9XXU9", "WBGene00006920", "Q22494", "WBGene00020507", "Q23680", "WBGene00006918", "P34462", "WBGene00010130", "Q9XW92", "WBGene00013025", "Q19626", "WBGene00006921", "Q9N5A0", "WBGene00004959", "Q95X44", "WBGene00006917", "P91303", "WBGene00006919", "C0HLB3", "WBGene00006911", "C0HLB4", "WBGene00006912", "Q95YD5", "WBGene00016258", "G5EEK9", "WBGene00006914", "G5EGP4", "WBGene00006915", "P30628", "WBGene00006768", "B2MZD0", "WBGene00006916", "Q20591", "WBGene00009882", "G5EDB8", "WBGene00006913" ] }, "reaction_10572542": { "compartment": "compartment_17938", "id": "reaction_10572542", "reactome": "R-CEL-9645598", "name": "RRAGC,D hydrolyzes GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10572426" ], "products": [ "species_10572430", "species_29372" ], "modifiers": [ [ "species_10572426", "catalyst" ], [ "species_10572540", "catalyst" ] ], "additional_components": [ "species_29420", "Q22743", "WBGene00006414", "G5EGB3", "WBGene00012497", "species_29438", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "Q9XXU9", "WBGene00006920", "Q22494", "WBGene00020507", "Q23680", "WBGene00006918", "P34462", "WBGene00010130", "Q9XW92", "WBGene00013025", "Q19626", "WBGene00006921", "Q9N5A0", "WBGene00004959", "Q95X44", "WBGene00006917", "P91303", "WBGene00006919", "C0HLB3", "WBGene00006911", "C0HLB4", "WBGene00006912", "Q95YD5", "WBGene00016258", "G5EEK9", "WBGene00006914", "G5EGP4", "WBGene00006915", "P30628", "WBGene00006768", "B2MZD0", "WBGene00006916", "Q20591", "WBGene00009882", "G5EDB8", "WBGene00006913", "species_29420", "Q22743", "WBGene00006414", "G5EGB3", "WBGene00012497", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "Q9XXU9", "WBGene00006920", "Q22494", "WBGene00020507", "Q23680", "WBGene00006918", "P34462", "WBGene00010130", "Q9XW92", "WBGene00013025", "Q19626", "WBGene00006921", "Q9N5A0", "WBGene00004959", "Q95X44", "WBGene00006917", "P91303", "WBGene00006919", "C0HLB3", "WBGene00006911", "C0HLB4", "WBGene00006912", "Q95YD5", "WBGene00016258", "G5EEK9", "WBGene00006914", "G5EGP4", "WBGene00006915", "P30628", "WBGene00006768", "B2MZD0", "WBGene00006916", "Q20591", "WBGene00009882", "G5EDB8", "WBGene00006913", "species_29420", "Q22743", "WBGene00006414", "G5EGB3", "WBGene00012497", "species_29438", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "Q9XXU9", "WBGene00006920", "Q22494", "WBGene00020507", "Q23680", "WBGene00006918", "P34462", "WBGene00010130", "Q9XW92", "WBGene00013025", "Q19626", "WBGene00006921", "Q9N5A0", "WBGene00004959", "Q95X44", "WBGene00006917", "P91303", "WBGene00006919", "C0HLB3", "WBGene00006911", "C0HLB4", "WBGene00006912", "Q95YD5", "WBGene00016258", "G5EEK9", "WBGene00006914", "G5EGP4", "WBGene00006915", "P30628", "WBGene00006768", "B2MZD0", "WBGene00006916", "Q20591", "WBGene00009882", "G5EDB8", "WBGene00006913", "S6FMZ4", "WBGene00017699", "H2L0I8", "WBGene00020208" ] }, "reaction_10572446": { "compartment": "compartment_17938", "id": "reaction_10572446", "reactome": "R-CEL-9640168", "name": "v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10572441" ], "products": [ "species_10572439", "species_10572435" ], "modifiers": [], "additional_components": [ "Q19425", "WBGene00008774", "species_29468", "species_29420", "G5EGB3", "WBGene00012497", "Q22743", "WBGene00006414", "species_29438", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "Q9XXU9", "WBGene00006920", "Q22494", "WBGene00020507", "Q23680", "WBGene00006918", "P34462", "WBGene00010130", "Q9XW92", "WBGene00013025", "Q19626", "WBGene00006921", "Q9N5A0", "WBGene00004959", "Q95X44", "WBGene00006917", "P91303", "WBGene00006919", "C0HLB3", "WBGene00006911", "C0HLB4", "WBGene00006912", "Q95YD5", "WBGene00016258", "G5EEK9", "WBGene00006914", "G5EGP4", "WBGene00006915", "P30628", "WBGene00006768", "B2MZD0", "WBGene00006916", "Q20591", "WBGene00009882", "G5EDB8", "WBGene00006913", "species_29420", "G5EGB3", "WBGene00012497", "Q22743", "WBGene00006414", "species_29438", "O17268", "WBGene00020101", "Q9N2U6", "WBGene00022402", "Q8WQG5", "WBGene00007390", "Q9XXU9", "WBGene00006920", "Q22494", "WBGene00020507", "Q23680", "WBGene00006918", "P34462", "WBGene00010130", "Q9XW92", "WBGene00013025", "Q19626", "WBGene00006921", "Q9N5A0", "WBGene00004959", "Q95X44", "WBGene00006917", "P91303", "WBGene00006919", "C0HLB3", "WBGene00006911", "C0HLB4", "WBGene00006912", "Q95YD5", "WBGene00016258", "G5EEK9", "WBGene00006914", "G5EGP4", "WBGene00006915", "P30628", "WBGene00006768", "B2MZD0", "WBGene00006916", "Q20591", "WBGene00009882", "G5EDB8", "WBGene00006913", "Q19425", "WBGene00008774", "species_29468" ] }, "reaction_10557938": { "compartment": "compartment_7660", "id": "reaction_10557938", "reactome": "R-CEL-6782141", "name": "Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10557934", "species_10508627" ], "products": [ "species_10557936" ], "modifiers": [], "additional_components": [ "Q95Y97", "WBGene00019767", "Q23088", "WBGene00022812", "Q7JKC3", "WBGene00010406", "P34545", "WBGene00000366", "Q21302", "WBGene00006963", "H2KYV0", "WBGene00016115", "P52652", "WBGene00012000", "Q18963", "WBGene00008403", "Q21554", "WBGene00010890", "Q23457", "WBGene00004320", "Q17392", "WBGene00000839", "Q19826", "WBGene00017830", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "O02092", "WBGene00018391", "Q9GR61", "WBGene00021347", "Q9N3C9", "WBGene00021845", "Q93338", "WBGene00007971", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q86D18", "WBGene00010011", "Q10051", "WBGene00020423", "Q20716", "WBGene00009966", "Q9U1Q7", "WBGene00001258", "Q9U2S6", "WBGene00000889", "P52009", "WBGene00000877", "P52016", "WBGene00000884", "P91175", "WBGene00016837", "Q22139", "WBGene00011411", "G5EBZ1", "WBGene00008140", "Q93456", "WBGene00008665", "G5EBZ1", "WBGene00008140", "Q93456", "WBGene00008665", "Q95Y97", "WBGene00019767", "Q23088", "WBGene00022812", "Q7JKC3", "WBGene00010406", "P34545", "WBGene00000366", "Q21302", "WBGene00006963", "H2KYV0", "WBGene00016115", "P52652", "WBGene00012000", "Q18963", "WBGene00008403", "Q21554", "WBGene00010890", "Q23457", "WBGene00004320", "Q17392", "WBGene00000839", "Q19826", "WBGene00017830", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "O02092", "WBGene00018391", "Q9GR61", "WBGene00021347", "Q9N3C9", "WBGene00021845", "Q93338", "WBGene00007971", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q86D18", "WBGene00010011", "Q10051", "WBGene00020423", "Q20716", "WBGene00009966", "Q9U1Q7", "WBGene00001258", "Q9U2S6", "WBGene00000889", "P52009", "WBGene00000877", "P52016", "WBGene00000884", "P91175", "WBGene00016837", "Q22139", "WBGene00011411" ] }, "reaction_10573109": { "compartment": "compartment_7660", "id": "reaction_10573109", "reactome": "R-CEL-9684118", "name": "ERCC3-facilitated RNA Pol II backtracking in TC-NER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10557921" ], "products": [ "species_113550", "species_113582", "species_10557932" ], "modifiers": [ [ "species_10557921", "catalyst" ] ], "additional_components": [ "Q23088", "WBGene00022812", "Q7JKC3", "WBGene00010406", "P34545", "WBGene00000366", "Q21302", "WBGene00006963", "H2KYV0", "WBGene00016115", "P52652", "WBGene00012000", "Q10051", "WBGene00020423", "Q20716", "WBGene00009966", "Q9U1Q7", "WBGene00001258", "Q9U2S6", "WBGene00000889", "P52009", "WBGene00000877", "P52016", "WBGene00000884", "P91175", "WBGene00016837", "Q22139", "WBGene00011411", "Q18963", "WBGene00008403", "Q21554", "WBGene00010890", "Q23457", "WBGene00004320", "Q17392", "WBGene00000839", "Q19826", "WBGene00017830", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "O02092", "WBGene00018391", "Q9GR61", "WBGene00021347", "Q9N3C9", "WBGene00021845", "Q93338", "WBGene00007971", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q86D18", "WBGene00010011", "Q23088", "WBGene00022812", "Q7JKC3", "WBGene00010406", "P34545", "WBGene00000366", "Q21302", "WBGene00006963", "H2KYV0", "WBGene00016115", "P52652", "WBGene00012000", "Q18963", "WBGene00008403", "Q21554", "WBGene00010890", "Q23457", "WBGene00004320", "Q17392", "WBGene00000839", "Q19826", "WBGene00017830", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "O02092", "WBGene00018391", "Q9GR61", "WBGene00021347", "Q9N3C9", "WBGene00021845", "Q93338", "WBGene00007971", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q86D18", "WBGene00010011", "Q10051", "WBGene00020423", "Q20716", "WBGene00009966", "Q9U1Q7", "WBGene00001258", "Q9U2S6", "WBGene00000889", "P52009", "WBGene00000877", "P52016", "WBGene00000884", "P91175", "WBGene00016837", "Q22139", "WBGene00011411", "Q23088", "WBGene00022812", "Q7JKC3", "WBGene00010406", "P34545", "WBGene00000366", "Q21302", "WBGene00006963", "H2KYV0", "WBGene00016115", "P52652", "WBGene00012000", "Q10051", "WBGene00020423", "Q20716", "WBGene00009966", "Q9U1Q7", "WBGene00001258", "Q9U2S6", "WBGene00000889", "P52009", "WBGene00000877", "P52016", "WBGene00000884", "P91175", "WBGene00016837", "Q22139", "WBGene00011411", "Q18963", "WBGene00008403", "Q21554", "WBGene00010890", "Q23457", "WBGene00004320", "Q17392", "WBGene00000839", "Q19826", "WBGene00017830", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "O02092", "WBGene00018391", "Q9GR61", "WBGene00021347", "Q9N3C9", "WBGene00021845", "Q93338", "WBGene00007971", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q86D18", "WBGene00010011" ] }, "reaction_10557924": { "compartment": "compartment_7660", "id": "reaction_10557924", "reactome": "R-CEL-6782131", "name": "ERCC2-facilitated RNA Pol II backtracking in TC-NER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10557910" ], "products": [ "species_113550", "species_113582", "species_10557921" ], "modifiers": [ [ "species_10557910", "catalyst" ] ], "additional_components": [ "Q23088", "WBGene00022812", "Q7JKC3", "WBGene00010406", "P34545", "WBGene00000366", "Q18963", "WBGene00008403", "Q21554", "WBGene00010890", "Q23457", "WBGene00004320", "Q17392", "WBGene00000839", "Q19826", "WBGene00017830", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "O02092", "WBGene00018391", "Q9GR61", "WBGene00021347", "Q9N3C9", "WBGene00021845", "Q93338", "WBGene00007971", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q86D18", "WBGene00010011", "Q21302", "WBGene00006963", "H2KYV0", "WBGene00016115", "P52652", "WBGene00012000", "Q10051", "WBGene00020423", "Q20716", "WBGene00009966", "Q9U1Q7", "WBGene00001258", "Q9U2S6", "WBGene00000889", "P52009", "WBGene00000877", "P52016", "WBGene00000884", "P91175", "WBGene00016837", "Q22139", "WBGene00011411", "Q23088", "WBGene00022812", "Q7JKC3", "WBGene00010406", "P34545", "WBGene00000366", "Q21302", "WBGene00006963", "H2KYV0", "WBGene00016115", "P52652", "WBGene00012000", "Q10051", "WBGene00020423", "Q20716", "WBGene00009966", "Q9U1Q7", "WBGene00001258", "Q9U2S6", "WBGene00000889", "P52009", "WBGene00000877", "P52016", "WBGene00000884", "P91175", "WBGene00016837", "Q22139", "WBGene00011411", "Q18963", "WBGene00008403", "Q21554", "WBGene00010890", "Q23457", "WBGene00004320", "Q17392", "WBGene00000839", "Q19826", "WBGene00017830", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "O02092", "WBGene00018391", "Q9GR61", "WBGene00021347", "Q9N3C9", "WBGene00021845", "Q93338", "WBGene00007971", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q86D18", "WBGene00010011", "Q23088", "WBGene00022812", "Q7JKC3", "WBGene00010406", "P34545", "WBGene00000366", "Q18963", "WBGene00008403", "Q21554", "WBGene00010890", "Q23457", "WBGene00004320", "Q17392", "WBGene00000839", "Q19826", "WBGene00017830", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "O02092", "WBGene00018391", "Q9GR61", "WBGene00021347", "Q9N3C9", "WBGene00021845", "Q93338", "WBGene00007971", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q86D18", "WBGene00010011", "Q21302", "WBGene00006963", "H2KYV0", "WBGene00016115", "P52652", "WBGene00012000", "Q10051", "WBGene00020423", "Q20716", "WBGene00009966", "Q9U1Q7", "WBGene00001258", "Q9U2S6", "WBGene00000889", "P52009", "WBGene00000877", "P52016", "WBGene00000884", "P91175", "WBGene00016837", "Q22139", "WBGene00011411" ] }, "reaction_10557943": { "compartment": "compartment_7660", "id": "reaction_10557943", "reactome": "R-CEL-6782204", "name": "5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10557936" ], "products": [ "species_10557940" ], "modifiers": [ [ "species_10557936", "catalyst" ] ], "additional_components": [ "G5EBZ1", "WBGene00008140", "Q93456", "WBGene00008665", "Q95Y97", "WBGene00019767", "Q23088", "WBGene00022812", "Q7JKC3", "WBGene00010406", "P34545", "WBGene00000366", "Q21302", "WBGene00006963", "H2KYV0", "WBGene00016115", "P52652", "WBGene00012000", "Q18963", "WBGene00008403", "Q21554", "WBGene00010890", "Q23457", "WBGene00004320", "Q17392", "WBGene00000839", "Q19826", "WBGene00017830", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "O02092", "WBGene00018391", "Q9GR61", "WBGene00021347", "Q9N3C9", "WBGene00021845", "Q93338", "WBGene00007971", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q86D18", "WBGene00010011", "Q10051", "WBGene00020423", "Q20716", "WBGene00009966", "Q9U1Q7", "WBGene00001258", "Q9U2S6", "WBGene00000889", "P52009", "WBGene00000877", "P52016", "WBGene00000884", "P91175", "WBGene00016837", "Q22139", "WBGene00011411", "Q18963", "WBGene00008403", "Q21554", "WBGene00010890", "Q23457", "WBGene00004320", "Q17392", "WBGene00000839", "P34545", "WBGene00000366", "Q23088", "WBGene00022812", "Q7JKC3", "WBGene00010406", "Q21302", "WBGene00006963", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q10051", "WBGene00020423", "Q20716", "WBGene00009966", "Q9U1Q7", "WBGene00001258", "Q9U2S6", "WBGene00000889", "P52009", "WBGene00000877", "P52016", "WBGene00000884", "P91175", "WBGene00016837", "Q22139", "WBGene00011411", "Q95Y97", "WBGene00019767", "Q19826", "WBGene00017830", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "O02092", "WBGene00018391", "Q9GR61", "WBGene00021347", "Q9N3C9", "WBGene00021845", "Q93338", "WBGene00007971", "G5EBZ1", "WBGene00008140", "Q93456", "WBGene00008665", "H2KYV0", "WBGene00016115", "P52652", "WBGene00012000", "Q86D18", "WBGene00010011", "G5EBZ1", "WBGene00008140", "Q93456", "WBGene00008665", "Q95Y97", "WBGene00019767", "Q23088", "WBGene00022812", "Q7JKC3", "WBGene00010406", "P34545", "WBGene00000366", "Q21302", "WBGene00006963", "H2KYV0", "WBGene00016115", "P52652", "WBGene00012000", "Q18963", "WBGene00008403", "Q21554", "WBGene00010890", "Q23457", "WBGene00004320", "Q17392", "WBGene00000839", "Q19826", "WBGene00017830", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "O02092", "WBGene00018391", "Q9GR61", "WBGene00021347", "Q9N3C9", "WBGene00021845", "Q93338", "WBGene00007971", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q86D18", "WBGene00010011", "Q10051", "WBGene00020423", "Q20716", "WBGene00009966", "Q9U1Q7", "WBGene00001258", "Q9U2S6", "WBGene00000889", "P52009", "WBGene00000877", "P52016", "WBGene00000884", "P91175", "WBGene00016837", "Q22139", "WBGene00011411" ] }, "reaction_10557958": { "compartment": "compartment_7660", "id": "reaction_10557958", "reactome": "R-CEL-6782211", "name": "DNA polymerases delta, epsilon or kappa bind the TC-NER site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10557940", "species_10557954", "species_10502642", "species_10557952" ], "products": [ "species_10557956" ], "modifiers": [], "additional_components": [ "Q18963", "WBGene00008403", "Q21554", "WBGene00010890", "Q23457", "WBGene00004320", "Q17392", "WBGene00000839", "P34545", "WBGene00000366", "Q23088", "WBGene00022812", "Q7JKC3", "WBGene00010406", "Q21302", "WBGene00006963", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q10051", "WBGene00020423", "Q20716", "WBGene00009966", "Q9U1Q7", "WBGene00001258", "Q9U2S6", "WBGene00000889", "P52009", "WBGene00000877", "P52016", "WBGene00000884", "P91175", "WBGene00016837", "Q22139", "WBGene00011411", "Q95Y97", "WBGene00019767", "Q19826", "WBGene00017830", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "O02092", "WBGene00018391", "Q9GR61", "WBGene00021347", "Q9N3C9", "WBGene00021845", "Q93338", "WBGene00007971", "G5EBZ1", "WBGene00008140", "Q93456", "WBGene00008665", "H2KYV0", "WBGene00016115", "P52652", "WBGene00012000", "Q86D18", "WBGene00010011", "O02115", "WBGene00003955", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "P90829", "WBGene00008645", "Q19366", "WBGene00008722", "Q21730", "WBGene00011016", "P34409", "WBGene00017696", "Q95Y97", "WBGene00019767", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "P90829", "WBGene00008645", "Q19366", "WBGene00008722", "Q21730", "WBGene00011016", "O02115", "WBGene00003955", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "P34409", "WBGene00017696", "Q18963", "WBGene00008403", "Q21554", "WBGene00010890", "Q23457", "WBGene00004320", "Q17392", "WBGene00000839", "P34545", "WBGene00000366", "Q23088", "WBGene00022812", "Q7JKC3", "WBGene00010406", "Q21302", "WBGene00006963", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q10051", "WBGene00020423", "Q20716", "WBGene00009966", "Q9U1Q7", "WBGene00001258", "Q9U2S6", "WBGene00000889", "P52009", "WBGene00000877", "P52016", "WBGene00000884", "P91175", "WBGene00016837", "Q22139", "WBGene00011411", "Q19826", "WBGene00017830", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "O02092", "WBGene00018391", "Q9GR61", "WBGene00021347", "Q9N3C9", "WBGene00021845", "Q93338", "WBGene00007971", "G5EBZ1", "WBGene00008140", "Q93456", "WBGene00008665", "H2KYV0", "WBGene00016115", "P52652", "WBGene00012000", "Q86D18", "WBGene00010011" ] }, "reaction_10553056": { "compartment": "compartment_70101", "id": "reaction_10553056", "reactome": "R-CEL-5618105", "name": "FKBP5 binds HSP90:ATP:STIP1:HSP70:nascent protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10553038", "species_10552844" ], "products": [ "species_10553046" ], "modifiers": [], "additional_components": [ "P09446", "WBGene00002005", "G5ECU5", "WBGene00009691", "O45246", "WBGene00002026", "G5EC99", "WBGene00009691", "species_113582", "O16259", "WBGene00019983", "Q18688", "WBGene00000915", "species_29358", "WBGene00001431", "O45418", "WBGene00001431", "P09446", "WBGene00002005", "G5ECU5", "WBGene00009691", "O45246", "WBGene00002026", "G5EC99", "WBGene00009691", "species_113582", "O16259", "WBGene00019983", "Q18688", "WBGene00000915", "species_29358" ] }, "reaction_10573120": { "compartment": "compartment_70101", "id": "reaction_10573120", "reactome": "R-CEL-9690534", "name": "SH binds NR3C1 (in HSP90:ATP:FKBP4:PTGES3:NR3C1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10552862", "species_5618094" ], "products": [ "species_10552864" ], "modifiers": [ [ "species_10573086", "catalyst" ] ], "additional_components": [ "O45418", "WBGene00001431", "Q18688", "WBGene00000915", "species_29358", "Q23280", "WBGene00022599", "species_193057", "species_469662", "CHEBI:16973", "species_193977", "CHEBI:27584", "CHEBI:17026", "species_193057", "species_469662", "CHEBI:16973", "species_193977", "CHEBI:27584", "CHEBI:17026", "O45418", "WBGene00001431", "Q18688", "WBGene00000915", "species_29358", "Q23280", "WBGene00022599", "O45418", "WBGene00001431", "Q18688", "WBGene00000915", "species_29358", "Q23280", "WBGene00022599" ] }, "reaction_10573088": { "compartment": "compartment_70101", "id": "reaction_10573088", "reactome": "R-CEL-9678925", "name": "NR3C1 binds NR3C1 agonists", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10552862", "species_9678859" ], "products": [ "species_10573086" ], "modifiers": [], "additional_components": [ "O45418", "WBGene00001431", "Q18688", "WBGene00000915", "species_29358", "Q23280", "WBGene00022599", "O45418", "WBGene00001431", "Q18688", "WBGene00000915", "species_29358", "Q23280", "WBGene00022599" ] }, "reaction_10547715": { "compartment": "compartment_70101", "id": "reaction_10547715", "reactome": "R-CEL-3371590", "name": "HSP70 binds to HSP40:nascent protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10547711", "species_10547713" ], "products": [ "species_10547586" ], "modifiers": [], "additional_components": [ "O45502", "WBGene00001030", "O16303", "WBGene00001037", "P09446", "WBGene00002005", "G5ECU5", "WBGene00009691", "O45246", "WBGene00002026", "G5EC99", "WBGene00009691", "species_29358", "P09446", "WBGene00002005", "G5ECU5", "WBGene00009691", "O45246", "WBGene00002026", "G5EC99", "WBGene00009691", "O45502", "WBGene00001030", "O16303", "WBGene00001037", "species_29358" ] }, "reaction_10553058": { "compartment": "compartment_70101", "id": "reaction_10553058", "reactome": "R-CEL-5618107", "name": "ATP binding to HSP90 triggers conformation change", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10547658", "species_113592" ], "products": [ "species_10553038" ], "modifiers": [], "additional_components": [ "Q18688", "WBGene00000915", "P09446", "WBGene00002005", "G5ECU5", "WBGene00009691", "O45246", "WBGene00002026", "G5EC99", "WBGene00009691", "species_113582", "O16259", "WBGene00019983", "P09446", "WBGene00002005", "G5ECU5", "WBGene00009691", "O45246", "WBGene00002026", "G5EC99", "WBGene00009691", "species_113582", "O16259", "WBGene00019983", "Q18688", "WBGene00000915", "species_29358" ] }, "reaction_10553060": { "compartment": "compartment_70101", "id": "reaction_10553060", "reactome": "R-CEL-5618110", "name": "p23 (PTGES3) binds HSP90:ATP:FKBP4:nascent protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10517708", "species_10553040" ], "products": [ "species_10547646", "species_10552852", "species_10547713" ], "modifiers": [], "additional_components": [ "WBGene00022599", "O45418", "WBGene00001431", "P09446", "WBGene00002005", "G5ECU5", "WBGene00009691", "O45246", "WBGene00002026", "G5EC99", "WBGene00009691", "species_113582", "O16259", "WBGene00019983", "Q18688", "WBGene00000915", "species_29358", "WBGene00019983", "O45418", "WBGene00001431", "Q23280", "WBGene00022599", "Q18688", "WBGene00000915", "species_29358", "P09446", "WBGene00002005", "G5ECU5", "WBGene00009691", "O45246", "WBGene00002026", "G5EC99", "WBGene00009691", "species_29358" ] }, "reaction_10547591": { "compartment": "compartment_70101", "id": "reaction_10547591", "reactome": "R-CEL-3371422", "name": "ATP hydrolysis by HSP70", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10547586" ], "products": [ "species_29372", "species_10547588" ], "modifiers": [ [ "species_10547586", "catalyst" ], [ "species_10547584", "catalyst" ] ], "additional_components": [ "P09446", "WBGene00002005", "G5ECU5", "WBGene00009691", "O45246", "WBGene00002026", "G5EC99", "WBGene00009691", "O45502", "WBGene00001030", "O16303", "WBGene00001037", "species_29358", "P09446", "WBGene00002005", "G5ECU5", "WBGene00009691", "O45246", "WBGene00002026", "G5EC99", "WBGene00009691", "O45502", "WBGene00001030", "O16303", "WBGene00001037", "species_113582", "P09446", "WBGene00002005", "G5ECU5", "WBGene00009691", "O45246", "WBGene00002026", "G5EC99", "WBGene00009691", "O45502", "WBGene00001030", "O16303", "WBGene00001037", "species_29358", "O45502", "WBGene00001030", "O16303", "WBGene00001037" ] }, "reaction_10553035": { "compartment": "compartment_70101", "id": "reaction_10553035", "reactome": "R-CEL-5618080", "name": "HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10552858", "species_10552864" ], "products": [ "species_10552874", "species_10552868" ], "modifiers": [ [ "species_10553033", "catalyst" ] ], "additional_components": [ "O45418", "WBGene00001431", "Q18688", "WBGene00000915", "species_29358", "Q23280", "WBGene00022599", "species_193057", "species_469662", "CHEBI:16973", "species_193977", "CHEBI:27584", "CHEBI:17026", "O45418", "WBGene00001431", "Q18688", "WBGene00000915", "species_29358", "Q23280", "WBGene00022599", "species_469662", "species_193977", "CHEBI:17026", "CHEBI:27584", "CHEBI:16973", "species_193057", "O45418", "WBGene00001431", "Q23280", "WBGene00022599", "Q18688", "WBGene00000915", "species_29358", "O45418", "WBGene00001431", "Q23280", "WBGene00022599", "Q18688", "WBGene00000915", "species_29358", "Q19020", "WBGene00000962", "O45087", "WBGene00015927", "Q65XS9", "WBGene00043067", "A0AAC1", "WBGene00012424", "Q7YTJ8", "WBGene00012425", "Q21557", "WBGene00010888", "Q22799", "WBGene00001005", "G5ED34", "WBGene00001007", "species_29420", "species_29438", "Q9NA98", "WBGene00013168", "P34685", "WBGene00000292", "P34686", "WBGene00000293", "Q18194", "WBGene00016124", "Q9N4I1", "WBGene00022118", "Q9N3F1", "WBGene00021827", "Q9GYR2", "WBGene00016793", "Q09248", "WBGene00001018", "E2JKZ0", "WBGene00001017" ] }, "reaction_10547660": { "compartment": "compartment_70101", "id": "reaction_10547660", "reactome": "R-CEL-3371503", "name": "STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10547646", "species_10547588", "species_10547652" ], "products": [ "species_10547658", "species_10547584" ], "modifiers": [], "additional_components": [ "WBGene00019983", "P09446", "WBGene00002005", "G5ECU5", "WBGene00009691", "O45246", "WBGene00002026", "G5EC99", "WBGene00009691", "O45502", "WBGene00001030", "O16303", "WBGene00001037", "species_113582", "Q18688", "WBGene00000915", "Q18688", "WBGene00000915", "P09446", "WBGene00002005", "G5ECU5", "WBGene00009691", "O45246", "WBGene00002026", "G5EC99", "WBGene00009691", "species_113582", "O16259", "WBGene00019983", "O45502", "WBGene00001030", "O16303", "WBGene00001037" ] }, "reaction_10573294": { "compartment": "compartment_70101", "id": "reaction_10573294", "reactome": "R-CEL-9705925", "name": "Androgens binds AR (in the HSP90 chaperone complex)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8979218", "species_10573288" ], "products": [ "species_10573292" ], "modifiers": [], "additional_components": [ "species_193057", "species_193079", "species_469662", "CHEBI:29117", "O45418", "WBGene00001431", "Q18688", "WBGene00000915", "species_29358", "Q23280", "WBGene00022599", "O45418", "WBGene00001431", "Q18688", "WBGene00000915", "species_29358", "species_193057", "species_193079", "species_469662", "CHEBI:29117", "Q23280", "WBGene00022599" ] }, "reaction_10553042": { "compartment": "compartment_70101", "id": "reaction_10553042", "reactome": "R-CEL-5618085", "name": "FKBP4 binds HSP90:ATP:STIP1:HSP70:nascent protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10553038", "species_10552850" ], "products": [ "species_10553040" ], "modifiers": [], "additional_components": [ "P09446", "WBGene00002005", "G5ECU5", "WBGene00009691", "O45246", "WBGene00002026", "G5EC99", "WBGene00009691", "species_113582", "O16259", "WBGene00019983", "Q18688", "WBGene00000915", "species_29358", "WBGene00001431", "O45418", "WBGene00001431", "P09446", "WBGene00002005", "G5ECU5", "WBGene00009691", "O45246", "WBGene00002026", "G5EC99", "WBGene00009691", "species_113582", "O16259", "WBGene00019983", "Q18688", "WBGene00000915", "species_29358" ] }, "reaction_10552854": { "compartment": "compartment_70101", "id": "reaction_10552854", "reactome": "R-CEL-5618073", "name": "FKBP4 replaces FKBP5 within HSP90:ATP:FKBP5:unfolded protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10552850", "species_10552848" ], "products": [ "species_10552844", "species_10552852" ], "modifiers": [ [ "species_5618094", "catalyst" ] ], "additional_components": [ "WBGene00001431", "Q23280", "WBGene00022599", "O45418", "WBGene00001431", "Q18688", "WBGene00000915", "species_29358", "WBGene00001431", "O45418", "WBGene00001431", "Q23280", "WBGene00022599", "Q18688", "WBGene00000915", "species_29358", "species_193057", "species_469662", "CHEBI:16973", "species_193977", "CHEBI:27584", "CHEBI:17026" ] }, "reaction_10553048": { "compartment": "compartment_70101", "id": "reaction_10553048", "reactome": "R-CEL-5618098", "name": "p23 (PTGES3) binds HSP90:ATP:FKBP5:nascent protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10517708", "species_10553046" ], "products": [ "species_10547646", "species_10547713", "species_10552848" ], "modifiers": [], "additional_components": [ "WBGene00022599", "O45418", "WBGene00001431", "P09446", "WBGene00002005", "G5ECU5", "WBGene00009691", "O45246", "WBGene00002026", "G5EC99", "WBGene00009691", "species_113582", "O16259", "WBGene00019983", "Q18688", "WBGene00000915", "species_29358", "WBGene00019983", "P09446", "WBGene00002005", "G5ECU5", "WBGene00009691", "O45246", "WBGene00002026", "G5EC99", "WBGene00009691", "species_29358", "Q23280", "WBGene00022599", "O45418", "WBGene00001431", "Q18688", "WBGene00000915", "species_29358" ] }, "reaction_10553054": { "compartment": "compartment_70101", "id": "reaction_10553054", "reactome": "R-CEL-5618099", "name": "SH binds SHR within the HSP90 chaperone complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10553052", "species_5618094" ], "products": [ "species_10552858" ], "modifiers": [], "additional_components": [ "O45418", "WBGene00001431", "Q18688", "WBGene00000915", "species_29358", "Q23280", "WBGene00022599", "species_193057", "species_469662", "CHEBI:16973", "species_193977", "CHEBI:27584", "CHEBI:17026", "O45418", "WBGene00001431", "Q18688", "WBGene00000915", "species_29358", "Q23280", "WBGene00022599" ] }, "reaction_10532184": { "compartment": "compartment_70101", "id": "reaction_10532184", "reactome": "R-CEL-1234161", "name": "HIF-alpha translocates from cytosol to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10532172" ], "products": [ "species_10532178" ], "modifiers": [], "additional_components": [ "WBGene00001851", "WBGene00001851" ] }, "reaction_10532232": { "compartment": "compartment_7660", "id": "reaction_10532232", "reactome": "R-CEL-1234167", "name": "Formation of HIF:CBP:p300 complex at promoters", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10532221", "species_29428", "species_10532228", "species_10532226" ], "products": [ "species_10532230" ], "modifiers": [], "additional_components": [ "G5EGD2", "WBGene00001851", "O02219", "WBGene00000095", "WBGene00000366", "WBGene00000366", "P34545", "WBGene00000366", "G5EGD2", "WBGene00001851", "O02219", "WBGene00000095" ] }, "reaction_10532250": { "compartment": "compartment_7660", "id": "reaction_10532250", "reactome": "R-CEL-1234171", "name": "HIF-alpha binds ARNT (HIF1-beta) forming HIF-alpha:ARNT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10532219", "species_10532178" ], "products": [ "species_10532221" ], "modifiers": [], "additional_components": [ "WBGene00000095", "WBGene00001851", "G5EGD2", "WBGene00001851", "O02219", "WBGene00000095" ] }, "reaction_10518832": { "compartment": "compartment_984", "id": "reaction_10518832", "reactome": "R-CEL-374919", "name": "Noradrenaline clearance from the synaptic cleft", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_374935" ], "products": [ "species_209789" ], "modifiers": [ [ "species_10518786", "catalyst" ] ], "additional_components": [ "WBGene00003987" ] }, "reaction_10572361": { "compartment": "compartment_876", "id": "reaction_10572361", "reactome": "R-CEL-9634834", "name": "ACHEIs bind ACHE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10518366", "species_9634838" ], "products": [ "species_10518393" ], "modifiers": [], "additional_components": [ "Q23268", "WBGene00013873", "Q04457", "WBGene00001578", "H9G2Y9", "WBGene00013874", "A0A1C3NSL8", "WBGene00017478", "Q4LDP0", "WBGene00020891", "Q21266", "WBGene00019477", "O01302", "WBGene00011362", "G5EDJ7", "WBGene00013875", "Q9XW75", "WBGene00013540", "Q22008", "WBGene00020125", "P92016", "WBGene00011364", "H2L0K7", "WBGene00020330", "Q23268", "WBGene00013873", "Q04457", "WBGene00001578", "H9G2Y9", "WBGene00013874", "A0A1C3NSL8", "WBGene00017478", "Q4LDP0", "WBGene00020891", "Q21266", "WBGene00019477", "O01302", "WBGene00011362", "G5EDJ7", "WBGene00013875", "Q9XW75", "WBGene00013540", "Q22008", "WBGene00020125", "P92016", "WBGene00011364", "H2L0K7", "WBGene00020330" ] }, "reaction_10567745": { "compartment": "compartment_20699", "id": "reaction_10567745", "reactome": "R-CEL-8877813", "name": "DENND5A,B exchange GTP for GDP on RAB39", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10567729" ], "products": [ "species_29420", "species_10567735", "species_10567253" ], "modifiers": [ [ "species_10567740", "catalyst" ] ], "additional_components": [ "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "Q18969", "WBGene00004286", "species_29420", "Q18969", "WBGene00004286", "species_29438", "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "WBGene00016889" ] }, "reaction_10567680": { "compartment": "compartment_13946", "id": "reaction_10567680", "reactome": "R-CEL-8877475", "name": "TRAPPC complexes exchange GTP for GDP on RAB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10567646", "species_29438" ], "products": [ "species_29420", "species_10567656", "species_10567253" ], "modifiers": [ [ "species_10567677", "catalyst" ] ], "additional_components": [ "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "Q9UAQ6", "WBGene00004266", "species_29420", "Q9UAQ6", "WBGene00004266", "species_29438", "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "Q9NA81", "WBGene00013259", "B1GRL5", "WBGene00077643", "Q93330", "WBGene00007956", "B1V899", "WBGene00022138", "Q9XU81", "WBGene00010699", "O02173", "WBGene00021046", "Q5WRR4", "WBGene00016614", "G4SNB8", "WBGene00044604", "Q95QQ2", "WBGene00016964", "P34605", "WBGene00014222", "Q9BI63", "WBGene00018512", "Q20100", "WBGene00018088" ] }, "reaction_10567296": { "compartment": "compartment_171062", "id": "reaction_10567296", "reactome": "R-CEL-8875320", "name": "RAB5 GEFs exchange GTP for GDP on RAB5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10567270" ], "products": [ "species_10567278", "species_29420", "species_10567253" ], "modifiers": [ [ "species_10567293", "catalyst" ] ], "additional_components": [ "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "P91857", "WBGene00004268", "species_29420", "P91857", "WBGene00004268", "species_29438", "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "G5ECF0", "WBGene00008183", "A0A486WY48", "WBGene00012644", "Q9GYH7", "WBGene00004377" ] }, "reaction_10567266": { "compartment": "compartment_216813", "id": "reaction_10567266", "reactome": "R-CEL-8875318", "name": "RAB3 GEFs exchange GTP for GDP on RAB3A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10567255" ], "products": [ "species_29420", "species_10567259", "species_10567253" ], "modifiers": [ [ "species_10567263", "catalyst" ] ], "additional_components": [ "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "Q94986", "WBGene00004267", "species_29420", "Q94986", "WBGene00004267", "species_29438", "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "O02626", "WBGene00000086", "Q20759", "WBGene00010045" ] }, "reaction_10567429": { "compartment": "compartment_263163", "id": "reaction_10567429", "reactome": "R-CEL-8876190", "name": "RAB8 GEFs exchange GTP for GDP on RAB8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10567407", "species_29438" ], "products": [ "species_29420", "species_10567419", "species_10567253" ], "modifiers": [ [ "species_10567426", "catalyst" ] ], "additional_components": [ "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "G5EFC1", "WBGene00004272", "Q21137", "WBGene00019317", "species_29420", "G5EFC1", "WBGene00004272", "Q21137", "WBGene00019317", "species_29438", "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "Q20759", "WBGene00010045" ] }, "reaction_10567401": { "compartment": "compartment_437051", "id": "reaction_10567401", "reactome": "R-CEL-8876188", "name": "DENND4s exchange GTP for GDP on RAB10", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10567385" ], "products": [ "species_10567389", "species_29420", "species_10567253" ], "modifiers": [ [ "species_10567394", "catalyst" ] ], "additional_components": [ "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "Q94148", "WBGene00004273", "species_29420", "Q94148", "WBGene00004273", "species_29438", "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "WBGene00018681" ] }, "reaction_10567468": { "compartment": "compartment_70101", "id": "reaction_10567468", "reactome": "R-CEL-8876446", "name": "p-ULK1 phosphorylates DENND3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10567461" ], "products": [ "species_29370", "species_10567465" ], "modifiers": [ [ "species_10554852", "catalyst" ] ], "additional_components": [ "WBGene00018681", "WBGene00018681", "WBGene00006786" ] }, "reaction_10568111": { "compartment": "compartment_70101", "id": "reaction_10568111", "reactome": "R-CEL-8933446", "name": "Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10567690", "species_113592" ], "products": [ "species_10568106", "species_29370" ], "modifiers": [ [ "species_10513848", "catalyst" ] ], "additional_components": [ "WBGene00004375", "WBGene00004375", "Q9XTG7", "WBGene00000103", "G4S4W1", "WBGene00016980", "Q17941", "WBGene00000102" ] }, "reaction_10567695": { "compartment": "compartment_262783", "id": "reaction_10567695", "reactome": "R-CEL-8877612", "name": "DENND1s exchange GTP for GDP on RAB35", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10567684" ], "products": [ "species_29420", "species_10567688", "species_10567253" ], "modifiers": [ [ "species_10567690", "catalyst" ] ], "additional_components": [ "species_29420", "Q9U2C3", "WBGene00004284", "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "Q9U2C3", "WBGene00004284", "species_29438", "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "WBGene00004375" ] }, "reaction_10567569": { "compartment": "compartment_171062", "id": "reaction_10567569", "reactome": "R-CEL-8876837", "name": "RAB21 GEFs exchange GTP for GDP on RAB21", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10567558" ], "products": [ "species_29420", "species_10567562", "species_10567253" ], "modifiers": [ [ "species_10567564", "catalyst" ] ], "additional_components": [ "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "Q22045", "WBGene00004279", "species_29420", "Q22045", "WBGene00004279", "species_29438", "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "WBGene00003477" ] }, "reaction_10567536": { "compartment": "compartment_70101", "id": "reaction_10567536", "reactome": "R-CEL-8876616", "name": "DENND6A,B exchange GTP for GDP on RAB14", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10567520" ], "products": [ "species_29420", "species_10567524", "species_10567253" ], "modifiers": [ [ "species_10567533", "catalyst" ] ], "additional_components": [ "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "Q93874", "WBGene00004276", "species_29420", "Q93874", "WBGene00004276", "species_29438", "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "O45074", "WBGene00018777" ] }, "reaction_10567638": { "compartment": "compartment_17938", "id": "reaction_10567638", "reactome": "R-CEL-8877451", "name": "MON1:CCZ1 exchanges GTP for GDP on RAB7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10567615", "species_29438" ], "products": [ "species_29420", "species_10567621", "species_10567253" ], "modifiers": [ [ "species_10567635", "catalyst" ] ], "additional_components": [ "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "species_29420", "Q23146", "WBGene00004271", "Q23146", "WBGene00004271", "species_29438", "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "Q9XVL8", "WBGene00010283", "Q9BI89", "WBGene00018321" ] }, "reaction_10567611": { "compartment": "compartment_5668575", "id": "reaction_10567611", "reactome": "R-CEL-8877308", "name": "MADD exchanges GTP for GDP on RAB27", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10567598", "species_29438" ], "products": [ "species_29420", "species_10567608", "species_10567253" ], "modifiers": [ [ "species_10553865", "catalyst" ] ], "additional_components": [ "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "G5EBS5", "WBGene00000089", "species_29420", "G5EBS5", "WBGene00000089", "species_29438", "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "WBGene00000086" ] }, "reaction_10567485": { "compartment": "compartment_262783", "id": "reaction_10567485", "reactome": "R-CEL-8876454", "name": "DENND3 exchanges GTP for GDP on RAB12", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10567472" ], "products": [ "species_29420", "species_10567480", "species_10567253" ], "modifiers": [ [ "species_10567482", "catalyst" ] ], "additional_components": [ "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "Q21137", "WBGene00019317", "G5EFC1", "WBGene00004272", "species_29420", "G5EFC1", "WBGene00004272", "Q21137", "WBGene00019317", "species_29438", "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "U4PBM1", "WBGene00018681" ] }, "reaction_10567516": { "compartment": "compartment_204883", "id": "reaction_10567516", "reactome": "R-CEL-8876615", "name": "RAB13 GEFs exchange GTP for GDP on RAB13", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10567503", "species_29438" ], "products": [ "species_29420", "species_10567511", "species_10567253" ], "modifiers": [ [ "species_10567513", "catalyst" ] ], "additional_components": [ "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "species_29420", "G5EFC1", "WBGene00004272", "Q21137", "WBGene00019317", "G5EFC1", "WBGene00004272", "Q21137", "WBGene00019317", "species_29438", "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051" ] }, "reaction_10567454": { "compartment": "compartment_263163", "id": "reaction_10567454", "reactome": "R-CEL-8876193", "name": "RIC1-RGP1 exchanges GTP for GDP on RAB6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10567435" ], "products": [ "species_29420", "species_10567451", "species_10567253" ], "modifiers": [ [ "species_10564567", "catalyst" ] ], "additional_components": [ "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "Q22782", "WBGene00004270", "P34213", "WBGene00004269", "species_29420", "P34213", "WBGene00004269", "Q22782", "WBGene00004270", "species_29438", "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "Q7YWW8", "WBGene00010815", "Q09417", "WBGene00011071" ] }, "reaction_10567774": { "compartment": "compartment_12045", "id": "reaction_10567774", "reactome": "R-CEL-8877998", "name": "RAB3GAP1:RAB3GAP2 exchanges GTP for GDP on RAB18", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10567761" ], "products": [ "species_29420", "species_10567253", "species_10567765" ], "modifiers": [ [ "species_10567771", "catalyst" ] ], "additional_components": [ "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "species_29420", "Q8MXS1", "WBGene00004277", "Q2V4S2", "WBGene00001558", "Q9BKQ5", "WBGene00022051", "Q8MXS1", "WBGene00004277", "species_29438", "Q93538", "WBGene00004317", "Q22670", "WBGene00004318" ] }, "reaction_10518562": { "compartment": "compartment_876", "id": "reaction_10518562", "reactome": "R-CEL-373741", "name": "SDK2 homophillic interaction", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10518558" ], "products": [ "species_10518560" ], "modifiers": [], "additional_components": [ "Q19663", "WBGene00017657", "Q9N3X8", "WBGene00004371", "Q19663", "WBGene00017657", "Q9N3X8", "WBGene00004371" ] }, "reaction_10518572": { "compartment": "compartment_876", "id": "reaction_10518572", "reactome": "R-CEL-373745", "name": "SDK1 homophillic interaction", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10518568" ], "products": [ "species_10518570" ], "modifiers": [], "additional_components": [ "Q19663", "WBGene00017657", "Q9N3X8", "WBGene00004371", "Q19663", "WBGene00017657", "Q9N3X8", "WBGene00004371" ] }, "reaction_10524053": { "compartment": "compartment_70101", "id": "reaction_10524053", "reactome": "R-CEL-432909", "name": "Interaction of Plectin with Integrin beta 4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10517311", "species_10514921" ], "products": [ "species_10524051" ], "modifiers": [], "additional_components": [ "Q03600", "WBGene00002081", "Q27874", "WBGene00003930", "WBGene00006876", "A0A1N7SYP3", "WBGene00006876", "Q03600", "WBGene00002081", "Q27874", "WBGene00003930" ] }, "reaction_10524069": { "compartment": "compartment_984", "id": "reaction_10524069", "reactome": "R-CEL-432956", "name": "BP230 is recruited to the hemidesmosome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10524061", "species_10524065" ], "products": [ "species_10524067" ], "modifiers": [], "additional_components": [ "A0A1N7SYP3", "WBGene00006876", "Q03600", "WBGene00002081", "Q27874", "WBGene00003930", "O44565", "WBGene00002247", "Q18823", "WBGene00016913", "Q19981", "WBGene00006432", "G5EG68", "WBGene00018304", "Q06561", "WBGene00006787", "G5ECE3", "WBGene00002248", "Q21313", "WBGene00001328", "A0A1N7SYP3", "WBGene00006876", "Q03600", "WBGene00002081", "Q27874", "WBGene00003930", "O44565", "WBGene00002247", "Q18823", "WBGene00016913", "Q19981", "WBGene00006432", "G5EG68", "WBGene00018304", "Q06561", "WBGene00006787", "G5ECE3", "WBGene00002248", "Q21313", "WBGene00001328" ] }, "reaction_10525053": { "compartment": "compartment_984", "id": "reaction_10525053", "reactome": "R-CEL-446089", "name": "BP180 interacts extracellularly with Laminin 332", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10525051", "species_10517354" ], "products": [ "species_10524061" ], "modifiers": [], "additional_components": [ "A0A1N7SYP3", "WBGene00006876", "Q03600", "WBGene00002081", "Q27874", "WBGene00003930", "O44565", "WBGene00002247", "Q18823", "WBGene00016913", "Q19981", "WBGene00006432", "G5EG68", "WBGene00018304", "Q06561", "WBGene00006787", "G5ECE3", "WBGene00002248", "Q21313", "WBGene00001328", "A0A1N7SYP3", "WBGene00006876", "Q03600", "WBGene00002081", "Q27874", "WBGene00003930", "O44565", "WBGene00002247", "Q18823", "WBGene00016913", "Q19981", "WBGene00006432", "G5EG68", "WBGene00018304", "Q06561", "WBGene00006787", "G5ECE3", "WBGene00002248", "Q21313", "WBGene00001328" ] }, "reaction_10525220": { "compartment": "compartment_70101", "id": "reaction_10525220", "reactome": "R-CEL-446391", "name": "Formation of the PINCH-ILK-parvin complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10525214", "species_10524045", "species_10525212" ], "products": [ "species_10525218" ], "modifiers": [], "additional_components": [ "WBGene00003931", "P50464", "WBGene00006826", "Q19157", "WBGene00004030", "Q9TZC4", "WBGene00003931" ] }, "reaction_10523749": { "compartment": "compartment_70101", "id": "reaction_10523749", "reactome": "R-CEL-430341", "name": "Mig-2 recruits Migfilin to the cell-ECM adhesions", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10523740", "species_10523745" ], "products": [ "species_10523747" ], "modifiers": [], "additional_components": [ "WBGene00006999", "WBGene00006836", "Q18685", "WBGene00006836", "Q9U3F4", "WBGene00006999" ] }, "reaction_10524049": { "compartment": "compartment_70101", "id": "reaction_10524049", "reactome": "R-CEL-432897", "name": "ILK interacts with beta-1 integrin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10524045", "species_10514200" ], "products": [ "species_10524047" ], "modifiers": [], "additional_components": [ "WBGene00003931", "WBGene00003930", "Q27874", "WBGene00003930", "Q9TZC4", "WBGene00003931" ] }, "reaction_10523759": { "compartment": "compartment_70101", "id": "reaction_10523759", "reactome": "R-CEL-430347", "name": "MigFilin associates with Filamin and F-actin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10523740", "species_10523755", "species_10523753" ], "products": [ "species_10523757" ], "modifiers": [], "additional_components": [ "WBGene00006999", "P0DM41", "WBGene00000063", "P0DM42", "WBGene00000065", "P10984", "WBGene00000064", "P10986", "WBGene00000066", "species_29358", "U4PBJ9", "WBGene00022048", "D0VWL6", "WBGene00016006", "U4PBJ9", "WBGene00022048", "D0VWL6", "WBGene00016006", "P0DM41", "WBGene00000063", "P0DM42", "WBGene00000065", "P10984", "WBGene00000064", "P10986", "WBGene00000066", "species_29358", "Q9U3F4", "WBGene00006999" ] }, "reaction_10525199": { "compartment": "compartment_70101", "id": "reaction_10525199", "reactome": "R-CEL-446364", "name": "Migfilin interacts with VASP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10523740", "species_10525195" ], "products": [ "species_10525197" ], "modifiers": [], "additional_components": [ "WBGene00006999", "WBGene00006770", "G5EG53", "WBGene00006770", "Q9U3F4", "WBGene00006999" ] }, "reaction_10513001": { "compartment": "compartment_876", "id": "reaction_10513001", "reactome": "R-CEL-190519", "name": "Internalization of gap junction plaques", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10512942", "species_10512947" ], "products": [ "species_10512999" ], "modifiers": [], "additional_components": [ "A0A486WXX8", "WBGene00000894", "P35603", "WBGene00001082", "WBGene00002041", "U4PBY2", "WBGene00002041", "P35603", "WBGene00001082", "A0A486WXX8", "WBGene00000894" ] }, "reaction_10513003": { "compartment": "compartment_70101", "id": "reaction_10513003", "reactome": "R-CEL-190829", "name": "Lysosomal degradation of gap junction plaques", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10512999" ], "products": [], "modifiers": [], "additional_components": [ "U4PBY2", "WBGene00002041", "P35603", "WBGene00001082", "A0A486WXX8", "WBGene00000894" ] }, "reaction_10508138": { "compartment": "compartment_7660", "id": "reaction_10508138", "reactome": "R-CEL-77071", "name": "Phosphorylation (Ser5) of RNA pol II CTD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10508135" ], "products": [ "species_113582", "species_10508131" ], "modifiers": [ [ "species_10508135", "catalyst" ] ], "additional_components": [ "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529" ] }, "reaction_10509405": { "compartment": "compartment_7660", "id": "reaction_10509405", "reactome": "R-CEL-113430", "name": "Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508135" ], "products": [ "species_10508135" ], "modifiers": [], "additional_components": [ "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q8MYM8", "WBGene00012694", "Q17558", "WBGene00015296", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529" ] }, "reaction_10558214": { "compartment": "compartment_984", "id": "reaction_10558214", "reactome": "R-CEL-6786652", "name": "CHIT1 hydrolyses CHIT to 3xADGP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_6786654" ], "products": [ "species_6786660" ], "modifiers": [ [ "species_10558211", "catalyst" ] ], "additional_components": [ "WBGene00000503" ] }, "reaction_10512728": { "compartment": "compartment_984", "id": "reaction_10512728", "reactome": "R-CEL-189062", "name": "lactose + H2O => D-glucose + D-galactose", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_188973", "species_109276" ], "products": [ "species_70115", "species_188995" ], "modifiers": [ [ "species_10512725", "catalyst" ] ], "additional_components": [ "Q18758", "WBGene00016848" ] }, "reaction_10513005": { "compartment": "compartment_984", "id": "reaction_10513005", "reactome": "R-CEL-191114", "name": "Digestion of branched starch (amylopectin) by extracellular amylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_189071" ], "products": [ "species_191103", "species_188986", "species_189108" ], "modifiers": [ [ "species_10512715", "catalyst" ] ], "additional_components": [ "species_70113", "WBGene00008220" ] }, "reaction_10512718": { "compartment": "compartment_984", "id": "reaction_10512718", "reactome": "R-CEL-188979", "name": "Digestion of linear starch (amylose) by extracellular amylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_189075" ], "products": [ "species_191103", "species_188986" ], "modifiers": [ [ "species_10512715", "catalyst" ] ], "additional_components": [ "species_70113", "WBGene00008220" ] }, "reaction_10556729": { "compartment": "compartment_7660", "id": "reaction_10556729", "reactome": "R-CEL-5691001", "name": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30555", "species_10556726" ], "products": [ "species_113541", "species_10556722" ], "modifiers": [ [ "species_10556726", "catalyst" ] ], "additional_components": [ "Q95Y97", "WBGene00019767", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "P90829", "WBGene00008645", "Q19366", "WBGene00008722", "Q21730", "WBGene00011016", "O02115", "WBGene00003955", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "P34409", "WBGene00017696", "Q95Y97", "WBGene00019767", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "P90829", "WBGene00008645", "Q19366", "WBGene00008722", "Q21730", "WBGene00011016", "O02115", "WBGene00003955", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "P34409", "WBGene00017696", "Q95Y97", "WBGene00019767", "Q18841", "WBGene00004337", "P53016", "WBGene00004340", "Q18547", "WBGene00004339", "O44175", "WBGene00004338", "P34429", "WBGene00018409", "P90829", "WBGene00008645", "Q19366", "WBGene00008722", "Q21730", "WBGene00011016", "O02115", "WBGene00003955", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "P34409", "WBGene00017696" ] }, "reaction_10556724": { "compartment": "compartment_7660", "id": "reaction_10556724", "reactome": "R-CEL-5691000", "name": "TFIIH binds GG-NER site to form a verification complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10556156", "species_10506316" ], "products": [ "species_10556158" ], "modifiers": [], "additional_components": [ "Q23457", "WBGene00004320", "Q17392", "WBGene00000839", "Q21554", "WBGene00010890", "P30644", "WBGene00011145", "Q23451", "WBGene00013924", "Q9N4C3", "WBGene00022296", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q23457", "WBGene00004320", "Q17392", "WBGene00000839", "Q21554", "WBGene00010890", "P30644", "WBGene00011145", "Q23451", "WBGene00013924", "Q9N4C3", "WBGene00022296", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725" ] }, "reaction_10556164": { "compartment": "compartment_7660", "id": "reaction_10556164", "reactome": "R-CEL-5689861", "name": "Recruitment of XPA and release of CAK ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10556158", "species_10556135" ], "products": [ "species_10506279", "species_10556162" ], "modifiers": [], "additional_components": [ "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q23457", "WBGene00004320", "Q17392", "WBGene00000839", "Q21554", "WBGene00010890", "P30644", "WBGene00011145", "Q23451", "WBGene00013924", "Q9N4C3", "WBGene00022296", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "WBGene00006963", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "K8F7X5", "WBGene00013529", "Q95PZ4", "WBGene00013441", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "P34567", "WBGene00011814", "Q9N3L2", "WBGene00021752", "Q21302", "WBGene00006963", "Q23457", "WBGene00004320", "Q17392", "WBGene00000839", "Q21554", "WBGene00010890", "P30644", "WBGene00011145", "Q23451", "WBGene00013924", "Q9N4C3", "WBGene00022296", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725" ] }, "reaction_10558516": { "compartment": "compartment_7660", "id": "reaction_10558516", "reactome": "R-CEL-6790454", "name": "SUMOylation of XPC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10556715", "species_10558502" ], "products": [ "species_10558511", "species_10546073" ], "modifiers": [ [ "species_10558513", "catalyst" ] ], "additional_components": [ "K8F7X5", "WBGene00013529", "Q95PZ4", "WBGene00013441", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "P34567", "WBGene00011814", "Q9N3L2", "WBGene00021752", "Q21302", "WBGene00006963", "Q23457", "WBGene00004320", "Q17392", "WBGene00000839", "Q21554", "WBGene00010890", "P30644", "WBGene00011145", "Q23451", "WBGene00013924", "Q9N4C3", "WBGene00022296", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "Q23457", "WBGene00004320", "Q17392", "WBGene00000839", "Q21554", "WBGene00010890", "K8F7X5", "WBGene00013529", "Q95PZ4", "WBGene00013441", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "P34567", "WBGene00011814", "Q9N3L2", "WBGene00021752", "Q21302", "WBGene00006963", "P30644", "WBGene00011145", "Q23451", "WBGene00013924", "P55853", "WBGene00004888", "Q9N4C3", "WBGene00022296", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "WBGene00006706" ] }, "reaction_10508629": { "compartment": "compartment_7660", "id": "reaction_10508629", "reactome": "R-CEL-109955", "name": "Formation of ERCC1:XPF heterodimeric complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10508620", "species_10508625" ], "products": [ "species_10508627" ], "modifiers": [], "additional_components": [ "WBGene00008665", "WBGene00008140", "G5EBZ1", "WBGene00008140", "Q93456", "WBGene00008665" ] }, "reaction_10556718": { "compartment": "compartment_7660", "id": "reaction_10556718", "reactome": "R-CEL-5690996", "name": "ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10556711" ], "products": [ "species_113550", "species_113582", "species_10556715" ], "modifiers": [ [ "species_10556711", "catalyst" ] ], "additional_components": [ "K8F7X5", "WBGene00013529", "Q95PZ4", "WBGene00013441", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "P34567", "WBGene00011814", "Q9N3L2", "WBGene00021752", "Q21302", "WBGene00006963", "Q23457", "WBGene00004320", "Q17392", "WBGene00000839", "Q21554", "WBGene00010890", "P30644", "WBGene00011145", "Q23451", "WBGene00013924", "Q9N4C3", "WBGene00022296", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "K8F7X5", "WBGene00013529", "Q95PZ4", "WBGene00013441", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "P34567", "WBGene00011814", "Q9N3L2", "WBGene00021752", "Q21302", "WBGene00006963", "Q23457", "WBGene00004320", "Q17392", "WBGene00000839", "Q21554", "WBGene00010890", "P30644", "WBGene00011145", "Q23451", "WBGene00013924", "Q9N4C3", "WBGene00022296", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "K8F7X5", "WBGene00013529", "Q95PZ4", "WBGene00013441", "O44499", "WBGene00019821", "Q09645", "WBGene00014230", "Q9N390", "WBGene00021904", "P34567", "WBGene00011814", "Q9N3L2", "WBGene00021752", "Q21302", "WBGene00006963", "Q23457", "WBGene00004320", "Q17392", "WBGene00000839", "Q21554", "WBGene00010890", "P30644", "WBGene00011145", "Q23451", "WBGene00013924", "Q9N4C3", "WBGene00022296", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725" ] }, "reaction_10544211": { "compartment": "compartment_984", "id": "reaction_10544211", "reactome": "R-CEL-2424243", "name": "SPARC binds Collagen type I fibril, hydroxylapatite and Ca2+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2672070", "species_10509625", "species_10526518", "species_74112" ], "products": [ "species_10544209" ], "modifiers": [], "additional_components": [ "Q9N4U2", "WBGene00000647", "WBGene00003893", "species_74016", "P34714", "WBGene00003893", "Q9N4U2", "WBGene00000647", "species_2672070" ] }, "reaction_10544420": { "compartment": "compartment_984", "id": "reaction_10544420", "reactome": "R-CEL-2467665", "name": "AGRN binds Beta amyloid fibril via GAG chains", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10544412", "species_10544416" ], "products": [ "species_10544418" ], "modifiers": [], "additional_components": [ "Q10651", "WBGene00000149", "Q10651", "WBGene00000149", "P34710", "unc-6" ] }, "reaction_10545273": { "compartment": "compartment_876", "id": "reaction_10545273", "reactome": "R-CEL-2681667", "name": "TNC binds Integrin alphaVbeta3, alphaVbeta6, alpha2beta1, alpha7beta1, alpha8beta1, alpha9beta1, alphaXbeta1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10517415", "species_10545269" ], "products": [ "species_10545271" ], "modifiers": [], "additional_components": [ "Q18096", "WBGene00007687", "P34446", "WBGene00003929", "Q27874", "WBGene00003930", "Q03600", "WBGene00002081", "P34446", "WBGene00003929", "Q27874", "WBGene00003930", "Q03600", "WBGene00002081", "Q18096", "WBGene00007687" ] }, "reaction_10545277": { "compartment": "compartment_984", "id": "reaction_10545277", "reactome": "R-CEL-2681681", "name": "Tenascins C, R, (X, N) bind fibronectin matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10544239", "species_10517394" ], "products": [ "species_10545275" ], "modifiers": [], "additional_components": [ "Q18096", "WBGene00007687", "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769", "Q18096", "WBGene00007687" ] }, "reaction_10557840": { "compartment": "compartment_7660", "id": "reaction_10557840", "reactome": "R-CEL-6781818", "name": "RNA Pol II initiates transcription from damaged DNA template", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10504431", "species_10506316", "species_5688114" ], "products": [ "species_10557838" ], "modifiers": [], "additional_components": [ "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "P16356", "WBGene00000123", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529" ] }, "reaction_10557845": { "compartment": "compartment_7660", "id": "reaction_10557845", "reactome": "R-CEL-6781824", "name": "Active RNA Pol II complex transcribes lesion-containing DNA template", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10557838", "species_6781829" ], "products": [ "species_113541", "species_10557842" ], "modifiers": [ [ "species_10557838", "catalyst" ] ], "additional_components": [ "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529" ] }, "reaction_10557865": { "compartment": "compartment_7660", "id": "reaction_10557865", "reactome": "R-CEL-6781833", "name": "ERCC8 (CSA) binds stalled RNA Pol II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10557852", "species_10557861" ], "products": [ "species_10557863", "species_10556775" ], "modifiers": [], "additional_components": [ "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q86D18", "WBGene00010011", "Q18963", "WBGene00008403", "Q21554", "WBGene00010890", "Q23457", "WBGene00004320", "Q17392", "WBGene00000839", "Q9GS00", "WBGene00000813", "Q9N359", "WBGene00000816", "P91001", "WBGene00000817", "O01422", "WBGene00000814", "Q9N425", "WBGene00000815", "Q95PZ0", "WBGene00000818", "Q18963", "WBGene00008403", "Q21554", "WBGene00010890", "Q23457", "WBGene00004320", "Q17392", "WBGene00000839", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q86D18", "WBGene00010011", "Q9GS00", "WBGene00000813", "Q9N359", "WBGene00000816", "P91001", "WBGene00000817", "O01422", "WBGene00000814", "Q9N425", "WBGene00000815", "Q95PZ0", "WBGene00000818" ] }, "reaction_10557913": { "compartment": "compartment_7660", "id": "reaction_10557913", "reactome": "R-CEL-6782069", "name": "UVSSA:USP7 deubiquitinates ERCC6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10557904" ], "products": [ "species_10502318", "species_10557910" ], "modifiers": [ [ "species_10557904", "catalyst" ] ], "additional_components": [ "Q23088", "WBGene00022812", "Q7JKC3", "WBGene00010406", "P34545", "WBGene00000366", "Q21302", "WBGene00006963", "H2KYV0", "WBGene00016115", "P52652", "WBGene00012000", "Q18963", "WBGene00008403", "Q21554", "WBGene00010890", "Q23457", "WBGene00004320", "Q17392", "WBGene00000839", "Q19826", "WBGene00017830", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "O02092", "WBGene00018391", "Q9GR61", "WBGene00021347", "Q9N3C9", "WBGene00021845", "Q93338", "WBGene00007971", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q86D18", "WBGene00010011", "Q10051", "WBGene00020423", "Q20716", "WBGene00009966", "Q9U1Q7", "WBGene00001258", "Q9U2S6", "WBGene00000889", "P52009", "WBGene00000877", "P52016", "WBGene00000884", "P91175", "WBGene00016837", "Q22139", "WBGene00011411", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "Q23088", "WBGene00022812", "Q7JKC3", "WBGene00010406", "P34545", "WBGene00000366", "Q18963", "WBGene00008403", "Q21554", "WBGene00010890", "Q23457", "WBGene00004320", "Q17392", "WBGene00000839", "Q19826", "WBGene00017830", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "O02092", "WBGene00018391", "Q9GR61", "WBGene00021347", "Q9N3C9", "WBGene00021845", "Q93338", "WBGene00007971", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q86D18", "WBGene00010011", "Q21302", "WBGene00006963", "H2KYV0", "WBGene00016115", "P52652", "WBGene00012000", "Q10051", "WBGene00020423", "Q20716", "WBGene00009966", "Q9U1Q7", "WBGene00001258", "Q9U2S6", "WBGene00000889", "P52009", "WBGene00000877", "P52016", "WBGene00000884", "P91175", "WBGene00016837", "Q22139", "WBGene00011411", "Q23088", "WBGene00022812", "Q7JKC3", "WBGene00010406", "P34545", "WBGene00000366", "Q21302", "WBGene00006963", "H2KYV0", "WBGene00016115", "P52652", "WBGene00012000", "Q18963", "WBGene00008403", "Q21554", "WBGene00010890", "Q23457", "WBGene00004320", "Q17392", "WBGene00000839", "Q19826", "WBGene00017830", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "O02092", "WBGene00018391", "Q9GR61", "WBGene00021347", "Q9N3C9", "WBGene00021845", "Q93338", "WBGene00007971", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q86D18", "WBGene00010011", "Q10051", "WBGene00020423", "Q20716", "WBGene00009966", "Q9U1Q7", "WBGene00001258", "Q9U2S6", "WBGene00000889", "P52009", "WBGene00000877", "P52016", "WBGene00000884", "P91175", "WBGene00016837", "Q22139", "WBGene00011411" ] }, "reaction_10557867": { "compartment": "compartment_7660", "id": "reaction_10557867", "reactome": "R-CEL-6781840", "name": "ERCC6 binds stalled RNA Pol II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10557850", "species_10557842" ], "products": [ "species_10557852" ], "modifiers": [], "additional_components": [ "WBGene00010011", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q86D18", "WBGene00010011" ] }, "reaction_10557886": { "compartment": "compartment_7660", "id": "reaction_10557886", "reactome": "R-CEL-6781867", "name": "ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10502318", "species_10557863" ], "products": [ "species_10557883" ], "modifiers": [ [ "species_10557863", "catalyst" ] ], "additional_components": [ "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "Q18963", "WBGene00008403", "Q21554", "WBGene00010890", "Q23457", "WBGene00004320", "Q17392", "WBGene00000839", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q86D18", "WBGene00010011", "Q18963", "WBGene00008403", "Q21554", "WBGene00010890", "Q23457", "WBGene00004320", "Q17392", "WBGene00000839", "Q19826", "WBGene00017830", "Q9XVH6", "WBGene00012187", "Q9U3I0", "WBGene00009078", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "P49632", "WBGene00006728", "P0CG71", "WBGene00006727", "P37165", "WBGene00006725", "Q10578", "WBGene00016140", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "O02092", "WBGene00018391", "Q9GR61", "WBGene00021347", "Q9N3C9", "WBGene00021845", "Q93338", "WBGene00007971", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q86D18", "WBGene00010011", "Q18963", "WBGene00008403", "Q21554", "WBGene00010890", "Q23457", "WBGene00004320", "Q17392", "WBGene00000839", "P16356", "WBGene00000123", "Q17684", "WBGene00007355", "Q19826", "WBGene00017830", "O02092", "WBGene00018391", "Q9XVH6", "WBGene00012187", "Q9GR61", "WBGene00021347", "Q9U3I0", "WBGene00009078", "Q9N3C9", "WBGene00021845", "Q965S0", "WBGene00022400", "Q9N5K2", "WBGene00019246", "Q93338", "WBGene00007971", "Q10578", "WBGene00016140", "Q9N3L2", "WBGene00021752", "P34567", "WBGene00011814", "Q9N390", "WBGene00021904", "Q9N4U0", "WBGene00021714", "O17245", "WBGene00018769", "G5EFV5", "WBGene00000408", "Q09645", "WBGene00014230", "O44499", "WBGene00019821", "Q95PZ4", "WBGene00013441", "K8F7X5", "WBGene00013529", "Q86D18", "WBGene00010011" ] }, "reaction_10543938": { "compartment": "compartment_876", "id": "reaction_10543938", "reactome": "R-CEL-2327746", "name": "FN1 aggregation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10515311", "species_10515319" ], "products": [ "species_10543936" ], "modifiers": [], "additional_components": [ "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769", "P34446", "WBGene00003929", "Q27874", "WBGene00003930", "species_266099", "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769", "P34446", "WBGene00003929", "Q27874", "WBGene00003930" ] }, "reaction_10544859": { "compartment": "compartment_984", "id": "reaction_10544859", "reactome": "R-CEL-2545196", "name": "FN1 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10515311" ], "products": [ "species_10515313" ], "modifiers": [], "additional_components": [ "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769", "Q18705", "WBGene00016769", "Q18914", "WBGene00017013", "Q9XXE9", "WBGene00016769" ] }, "reaction_10564552": { "compartment": "compartment_20699", "id": "reaction_10564552", "reactome": "R-CEL-8847637", "name": "NSF and SNAPs bind the cis-SNARE at the Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10564548", "species_10557329", "species_10557345" ], "products": [ "species_10564550" ], "modifiers": [], "additional_components": [ "Q9TXZ9", "WBGene00015164", "Q20797", "WBGene00006373", "Q95ZW1", "WBGene00017273", "Q94392", "WBGene00003818", "Q18921", "WBGene00017016", "Q94392", "WBGene00003818", "Q18921", "WBGene00017016", "Q9TXZ9", "WBGene00015164", "Q20797", "WBGene00006373", "Q95ZW1", "WBGene00017273" ] }, "reaction_10564571": { "compartment": "compartment_20699", "id": "reaction_10564571", "reactome": "R-CEL-8847887", "name": "RAB33B:GTP binds RIC1:RGP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10564567", "species_10564561" ], "products": [ "species_10564569" ], "modifiers": [], "additional_components": [ "Q7YWW8", "WBGene00010815", "Q09417", "WBGene00011071", "Q20365", "WBGene00004283", "species_29438", "Q20365", "WBGene00004283", "species_29438", "Q7YWW8", "WBGene00010815", "Q09417", "WBGene00011071" ] }, "reaction_10564079": { "compartment": "compartment_20699", "id": "reaction_10564079", "reactome": "R-CEL-6811433", "name": "The COG tethering complex interacts with numerous SNAREs at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10563498", "species_10564075" ], "products": [ "species_10564077" ], "modifiers": [], "additional_components": [ "Q21270", "WBGene00019481", "Q6AW08", "WBGene00022121", "Q95XZ0", "WBGene00021784", "G5EE66", "WBGene00003258", "O44502", "WBGene00019820", "Q21444", "WBGene00000585", "P91151", "WBGene00016608", "Q9TY08", "WBGene00022534", "Q95ZW1", "WBGene00017273", "P41941", "WBGene00007128", "O18230", "WBGene00013302", "Q20797", "WBGene00006373", "H2KYN0", "WBGene00016643", "P83351", "WBGene00019305", "Q9TY08", "WBGene00022534", "Q95ZW1", "WBGene00017273", "P41941", "WBGene00007128", "O18230", "WBGene00013302", "Q20797", "WBGene00006373", "H2KYN0", "WBGene00016643", "P83351", "WBGene00019305", "Q21270", "WBGene00019481", "Q6AW08", "WBGene00022121", "Q95XZ0", "WBGene00021784", "G5EE66", "WBGene00003258", "O44502", "WBGene00019820", "Q21444", "WBGene00000585", "P91151", "WBGene00016608" ] }, "reaction_10564958": { "compartment": "compartment_20699", "id": "reaction_10564958", "reactome": "R-CEL-8849748", "name": "The COG complex binds RABs at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10564954", "species_10563498" ], "products": [ "species_10564956" ], "modifiers": [], "additional_components": [ "species_29438", "Q18969", "WBGene00004286", "Q9XWZ3", "WBGene00004282", "P34213", "WBGene00004269", "Q22782", "WBGene00004270", "Q21270", "WBGene00019481", "Q6AW08", "WBGene00022121", "Q95XZ0", "WBGene00021784", "G5EE66", "WBGene00003258", "O44502", "WBGene00019820", "Q21444", "WBGene00000585", "P91151", "WBGene00016608", "Q21270", "WBGene00019481", "Q6AW08", "WBGene00022121", "Q95XZ0", "WBGene00021784", "G5EE66", "WBGene00003258", "O44502", "WBGene00019820", "Q21444", "WBGene00000585", "P91151", "WBGene00016608", "species_29438", "Q18969", "WBGene00004286", "Q9XWZ3", "WBGene00004282", "P34213", "WBGene00004269", "Q22782", "WBGene00004270" ] }, "reaction_10543921": { "compartment": "compartment_984", "id": "reaction_10543921", "reactome": "R-CEL-2327733", "name": "FN1 binds Collagen types I-V, VII", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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